Watching sexy displays improves hatching success and offspring growth through maternal allocation.

PubMed

Loyau, Adeline; Lacroix, Frédéric

2010-11-22

Male attractiveness can have tremendous effects on the fitness of his offspring via good genes, but also via enhanced maternal allocation of resources. Yet the proximate mechanisms influencing differential maternal allocation in relation to male sexiness are poorly known. Here, we studied the importance of visual stimulation for maternal allocation in the Houbara bustard, a vulnerable bird species bred in captivity to support wild populations. Artificial insemination allowed controlling for potential confounding factors, such as a male's territory quality, social interactions or sperm quality/quantity, probably linked to mate attractiveness. We show that artificially inseminated females stimulated by highly displaying males increased their hatching success, owing to increased fertilization success. The females also increased the allocation of maternal androgens in their eggs, leading to an increase of circulating testosterone and growth rate in chicks. Hence, visual stimulation of the females can promote differential maternal allocation and favour offspring fitness. Our results further suggest that using artificial insemination for species conservation without appropriate stimulation of the breeding females probably has negative impacts on their breeding performance and therefore on population viability.

Criticality of iron and its principal alloying elements.

PubMed

Nuss, Philip; Harper, E M; Nassar, N T; Reck, Barbara K; Graedel, T E

2014-04-01

Because modern technology depends on reliable supplies of a wide variety of materials and because of increasing concern about those supplies, a comprehensive methodology was created to quantify the degree of criticality of the metals of the periodic table. In this paper, we apply this methodology to iron and several of its main alloying elements (i.e., vanadium, chromium, manganese, and niobium). These elements represent the basic metals of any industrial society and are vital for national security and economic well-being. Assessments relating to the dimensions of criticality - supply risk, vulnerability to supply restriction, and environmental implications - for 2008 are made on the global level and for the United States. Evaluations of each of the multiple indicators are presented, with aggregate results plotted in "criticality space", together with Monte Carlo simulation-derived "uncertainty cloud" estimates. Iron has the lowest supply risk, primarily because of its widespread geological occurrence. Vanadium displays the highest cradle-to-gate environmental implications, followed by niobium, chromium, manganese, and iron. Chromium and manganese, both essential in steel making, display the highest vulnerability to supply restriction, largely because substitution or substitution at equal performance is not possible for all end-uses. From a comprehensive perspective, we regard the overall criticality as low for iron and modest for the alloying elements we evaluated.

Identifying typical patterns of vulnerability: A 5-step approach based on cluster analysis

NASA Astrophysics Data System (ADS)

Sietz, Diana; Lüdeke, Matthias; Kok, Marcel; Lucas, Paul; Carsten, Walther; Janssen, Peter

2013-04-01

Specific processes that shape the vulnerability of socio-ecological systems to climate, market and other stresses derive from diverse background conditions. Within the multitude of vulnerability-creating mechanisms, distinct processes recur in various regions inspiring research on typical patterns of vulnerability. The vulnerability patterns display typical combinations of the natural and socio-economic properties that shape a systems' vulnerability to particular stresses. Based on the identification of a limited number of vulnerability patterns, pattern analysis provides an efficient approach to improving our understanding of vulnerability and decision-making for vulnerability reduction. However, current pattern analyses often miss explicit descriptions of their methods and pay insufficient attention to the validity of their groupings. Therefore, the question arises as to how do we identify typical vulnerability patterns in order to enhance our understanding of a systems' vulnerability to stresses? A cluster-based pattern recognition applied at global and local levels is scrutinised with a focus on an applicable methodology and practicable insights. Taking the example of drylands, this presentation demonstrates the conditions necessary to identify typical vulnerability patterns. They are summarised in five methodological steps comprising the elicitation of relevant cause-effect hypotheses and the quantitative indication of mechanisms as well as an evaluation of robustness, a validation and a ranking of the identified patterns. Reflecting scale-dependent opportunities, a global study is able to support decision-making with insights into the up-scaling of interventions when available funds are limited. In contrast, local investigations encourage an outcome-based validation. This constitutes a crucial step in establishing the credibility of the patterns and hence their suitability for informing extension services and individual decisions. In this respect, working at the local level provides a clear advantage since, to a large extent, limitations in globally available observational data constrain such a validation on the global scale. Overall, the five steps are outlined in detail in order to facilitate and motivate the application of pattern recognition in other research studies concerned with vulnerability analysis, including future applications to different vulnerability frameworks. Such applications could promote the refinement of mechanisms in specific contexts and advance methodological adjustments. This would further increase the value of identifying typical patterns in the properties of socio-ecological systems for an improved understanding and management of the relation between these systems and particular stresses.

Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.

PubMed

Gautam, Mukesh; Jara, Javier H; Sekerkova, Gabriella; Yasvoina, Marina V; Martina, Marco; Özdinler, P Hande

2016-03-15

Mutations in the ALS2 gene result in early-onset amyotrophic lateral sclerosis, infantile-onset ascending hereditary spastic paraplegia and juvenile primary lateral sclerosis, suggesting prominent upper motor neuron involvement. However, the importance of alsin function for corticospinal motor neuron (CSMN) health and stability remains unknown. To date, four separate alsin knockout (Alsin(KO)) mouse models have been generated, and despite hopes of mimicking human pathology, none displayed profound motor function defects. This, however, does not rule out the possibility of neuronal defects within CSMN, which is not easy to detect in these mice. Detailed cellular analysis of CSMN has been hampered due to their limited numbers and the complex and heterogeneous structure of the cerebral cortex. In an effort to visualize CSMN in vivo and to investigate precise aspects of neuronal abnormalities in the absence of alsin function, we generated Alsin(KO)-UeGFP mice, by crossing Alsin(KO) and UCHL1-eGFP mice, a CSMN reporter line. We find that CSMN display vacuolated apical dendrites with increased autophagy, shrinkage of soma size and axonal pathology even in the pons region. Immunocytochemistry coupled with electron microscopy reveal that alsin is important for maintaining cellular cytoarchitecture and integrity of cellular organelles. In its absence, CSMN displays selective defects both in mitochondria and Golgi apparatus. UCHL1-eGFP mice help understand the underlying cellular factors that lead to CSMN vulnerability in diseases, and our findings reveal unique importance of alsin function for CSMN health and stability. © The Author 2016. Published by Oxford University Press.

Error and attack tolerance of complex networks

NASA Astrophysics Data System (ADS)

Albert, Réka; Jeong, Hawoong; Barabási, Albert-László

2000-07-01

Many complex systems display a surprising degree of tolerance against errors. For example, relatively simple organisms grow, persist and reproduce despite drastic pharmaceutical or environmental interventions, an error tolerance attributed to the robustness of the underlying metabolic network. Complex communication networks display a surprising degree of robustness: although key components regularly malfunction, local failures rarely lead to the loss of the global information-carrying ability of the network. The stability of these and other complex systems is often attributed to the redundant wiring of the functional web defined by the systems' components. Here we demonstrate that error tolerance is not shared by all redundant systems: it is displayed only by a class of inhomogeneously wired networks, called scale-free networks, which include the World-Wide Web, the Internet, social networks and cells. We find that such networks display an unexpected degree of robustness, the ability of their nodes to communicate being unaffected even by unrealistically high failure rates. However, error tolerance comes at a high price in that these networks are extremely vulnerable to attacks (that is, to the selection and removal of a few nodes that play a vital role in maintaining the network's connectivity). Such error tolerance and attack vulnerability are generic properties of communication networks.

Video game violence use among "vulnerable" populations: the impact of violent games on delinquency and bullying among children with clinically elevated depression or attention deficit symptoms.

PubMed

Ferguson, Christopher J; Olson, Cheryl K

2014-01-01

The issue of children's exposure to violent video games has been a source of considerable debate for several decades. Questions persist whether children with pre-existing mental health problems may be influenced adversely by exposure to violent games, even if other children are not. We explored this issue with 377 children (62 % female, mixed ethnicity, mean age = 12.93) displaying clinically elevated attention deficit or depressive symptoms on the Pediatric Symptom Checklist. Results from our study found no evidence for increased bullying or delinquent behaviors among youth with clinically elevated mental health symptoms who also played violent video games. Our results did not support the hypothesis that children with elevated mental health symptoms constitute a "vulnerable" population for video game violence effects. Implications and suggestions for further research are provided.

Extreme rainfall, vulnerability and risk: a continental-scale assessment for South America.

PubMed

Vörösmarty, Charles J; Bravo de Guenni, Lelys; Wollheim, Wilfred M; Pellerin, Brian; Bjerklie, David; Cardoso, Manoel; D'Almeida, Cassiano; Green, Pamela; Colon, Lilybeth

2013-11-13

Extreme weather continues to preoccupy society as a formidable public safety concern bearing huge economic costs. While attention has focused on global climate change and how it could intensify key elements of the water cycle such as precipitation and river discharge, it is the conjunction of geophysical and socioeconomic forces that shapes human sensitivity and risks to weather extremes. We demonstrate here the use of high-resolution geophysical and population datasets together with documentary reports of rainfall-induced damage across South America over a multi-decadal, retrospective time domain (1960-2000). We define and map extreme precipitation hazard, exposure, affectedpopulations, vulnerability and risk, and use these variables to analyse the impact of floods as a water security issue. Geospatial experiments uncover major sources of risk from natural climate variability and population growth, with change in climate extremes bearing a minor role. While rural populations display greatest relative sensitivity to extreme rainfall, urban settings show the highest rates of increasing risk. In the coming decades, rapid urbanization will make South American cities the focal point of future climate threats but also an opportunity for reducing vulnerability, protecting lives and sustaining economic development through both traditional and ecosystem-based disaster risk management systems.

Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension.

PubMed

Ou, Yvonne; Jo, Rebecca E; Ullian, Erik M; Wong, Rachel O L; Della Santina, Luca

2016-08-31

Key issues concerning ganglion cell type-specific loss and synaptic changes in animal models of experimental glaucoma remain highly debated. Importantly, changes in the structure and function of various RGC types that occur early, within 14 d after acute, transient intraocular pressure elevation, have not been previously assessed. Using biolistic transfection of individual RGCs and multielectrode array recordings to measure light responses in mice, we examined the effects of laser-induced ocular hypertension on the structure and function of a subset of RGCs. Among the α-like RGCs studied, αOFF-transient RGCs exhibited higher rates of cell death, with corresponding reductions in dendritic area, dendritic complexity, and synapse density. Functionally, OFF-transient RGCs displayed decreases in spontaneous activity and receptive field size. In contrast, neither αOFF-sustained nor αON-sustained RGCs displayed decreases in light responses, although they did exhibit a decrease in excitatory postsynaptic sites, suggesting that synapse loss may be one of the earliest signs of degeneration. Interestingly, presynaptic ribbon density decreased to a greater degree in the OFF sublamina of the inner plexiform layer, corroborating the hypothesis that RGCs with dendrites stratifying in the OFF sublamina may be damaged early. Indeed, OFF arbors of ON-OFF RGCs lose complexity more rapidly than ON arbors. Our results reveal type-specific differences in RGC responses to injury with a selective vulnerability of αOFF-transient RGCs, and furthermore, an increased susceptibility of synapses in the OFF sublamina. The selective vulnerability of specific RGC types offers new avenues for the design of more sensitive functional tests and targeted neuroprotection. Conflicting reports regarding the selective vulnerability of specific retinal ganglion cell (RGC) types in glaucoma exist. We examine, for the first time, the effects of transient intraocular pressure elevation on the structure and function of various RGC types. Among the α-like RGCs studied, αOFF-transient RGCs are the most vulnerable to transient transient intraocular pressure elevation as measured by rates of cell death, morphologic alterations in dendrites and synapses, and physiological dysfunction. Specifically, we found that presynaptic ribbon density decreased to a greater degree in the OFF sublamina of the inner plexiform layer. Our results suggest selective vulnerability both of specific types of RGCs and of specific inner plexiform layer sublaminae, opening new avenues for identifying novel diagnostic and treatment targets in glaucoma. Copyright © 2016 the authors 0270-6474/16/369240-13$15.00/0.

Usability of a Novel Mobile Health iPad App by Vulnerable Populations.

PubMed

Miller, David P; Weaver, Kathryn E; Case, L Doug; Babcock, Donald; Lawler, Donna; Denizard-Thompson, Nancy; Pignone, Michael P; Spangler, John G

2017-04-11

Recent advances in mobile technologies have created new opportunities to reach broadly into populations that are vulnerable to health disparities. However, mobile health (mHealth) strategies could paradoxically increase health disparities, if low socioeconomic status individuals lack the technical or literacy skills needed to navigate mHealth programs. The aim of this study was to determine whether patients from vulnerable populations could successfully navigate and complete an mHealth patient decision aid. We analyzed usability data from a randomized controlled trial of an iPad program designed to promote colorectal cancer (CRC) screening. The trial was conducted in six primary care practices and enrolled 450 patients, aged 50-74 years, who were due for CRC screening. The iPad program included a self-survey and randomly displayed either a screening decision aid or a video about diet and exercise. We measured participant ability to complete the program without assistance and participant-rated program usability. Two-thirds of the participants (305/450) were members of a vulnerable population (limited health literacy, annual income < US $20,000, or black race). Over 92% (417/450) of the participants rated the program highly on all three usability items (90.8% for vulnerable participants vs 96.6% for nonvulnerable participants, P=.006). Only 6.9% (31/450) of the participants needed some assistance to complete the program. In multivariable logistic regression, being a member of a vulnerable population was not associated with needing assistance. Only older age, less use of text messaging (short message service, SMS), and lack of Internet use predicted needing assistance. Individuals who are vulnerable to health disparities can successfully use well-designed mHealth programs. Future research should investigate whether mHealth interventions can reduce health disparities. ©David P Miller Jr, Kathryn E Weaver, L Doug Case, Donald Babcock, Donna Lawler, Nancy Denizard-Thompson, Michael P Pignone, John G Spangler. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 11.04.2017.

Personality traits in rats predict vulnerability and resilience to developing stress-induced depression-like behaviors, HPA axis hyper-reactivity and brain changes in pERK1/2 activity.

PubMed

Castro, Jorge E; Diessler, Shanaz; Varea, Emilio; Márquez, Cristina; Larsen, Marianne H; Cordero, M Isabel; Sandi, Carmen

2012-08-01

Emerging evidence indicates that certain behavioral traits, such as anxiety, are associated with the development of depression-like behaviors after exposure to chronic stress. However, single traits do not explain the wide variability in vulnerability to stress observed in outbred populations. We hypothesized that a combination of behavioral traits might provide a better characterization of an individual's vulnerability to prolonged stress. Here, we sought to determine whether the characterization of relevant behavioral traits in rats could aid in identifying individuals with different vulnerabilities to developing stress-induced depression-like behavioral alterations. We also investigated whether behavioral traits would be related to the development of alterations in the hypothalamic-pituitary-adrenal axis and in brain activity - as measured through phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2)--in response to an acute stressor following either sub-chronic (2 weeks) or chronic (4 weeks) unpredictable stress (CUS). Sprague-Dawley rats were characterized using a battery of behavioral tasks, and three principal traits were identified: anxiety, exploration and activity. When combined, the first two traits were found to explain the variability in the stress responses. Our findings confirm the increased risk of animals with high anxiety developing certain depression-like behaviors (e.g., increased floating time in the forced swim test) when progressively exposed to stress. In contrast, the behavioral profile based on combined low anxiety and low exploration was resistant to alterations related to social behaviors, while the high anxiety and low exploration profile displayed a particularly vulnerable pattern of physiological and neurobiological responses after sub-chronic stress exposure. Our findings indicate important differences in animals' vulnerability and/or resilience to the effects of repeated stress, particularly during initial or intermediate levels of stress exposure, and they highlight that the behavioral inhibition profile of an animal provides a particular susceptibility to responding in a deleterious manner to stress. Copyright © 2011 Elsevier Ltd. All rights reserved.

Identification and characteristics of vulnerable adults attending an inner city sexual health service.

PubMed

Sullivan, Verity; Cheserem, Emily; Milne, Cliodhna; Hopkins, Marina; Lock, Eleanor; Hamlyn, Elizabeth

2015-10-01

Adult safeguarding is the function of protecting vulnerable adults from abuse or neglect. The 2012 Department of Health Draft Care and Support Bill highlighted adult safeguarding as a key government priority and stated that a clear framework is required for organisations dealing with 'adults at risk'. Adults at risk present to sexual health services but no formal guidance currently exists to aid their identification and management in this setting. We conducted a retrospective case note review which identified that vulnerable adults attend our service. They may display recognised risk factors, awareness of which is likely to facilitate identification and assessment of this group and aid appropriate onward referral. © The Author(s) 2015.

Mapping Vulnerability to Disasters in Latin America and the Caribbean, 1900-2007

USGS Publications Warehouse

Maynard-Ford, Miriam C.; Phillips, Emily C.; Chirico, Peter G.

2008-01-01

The vulnerability of a population and its infrastructure to disastrous events is a factor of both the probability of a hazardous event occurring and the community's ability to cope with the resulting impacts. Therefore, the ability to accurately identify vulnerable populations and places in order to prepare for future hazards is of critical importance for disaster mitigation programs. This project created maps of higher spatial resolution of vulnerability to disaster in Latin America and the Caribbean from 1900 to 2007 by mapping disaster data by first-level administrative boundaries with the objective of identifying geographic trends in regional occurrences of disasters and vulnerable populations. The method of mapping by administrative level is an improvement on displaying and analyzing disasters at the country level and shows the relative intensity of vulnerability within and between countries in the region. Disaster mapping at the country level produces only a basic view of which countries experience various types of natural disasters. Through disaggregation, the data show which geographic areas of these countries, including populated areas, are historically most susceptible to different hazard types.

Mic60/Mitofilin Overexpression Alters Mitochondrial Dynamics and Attenuates Vulnerability of Dopaminergic Cells to Dopamine and Rotenone

PubMed Central

Van Laar, Victor S.; Berman, Sarah B.; Hastings, Teresa G.

2017-01-01

Mitochondrial dysfunction has been implicated in Parkinson’s disease (PD) neuropathology. Mic60, also known as mitofilin, is a protein of the inner mitochondrial membrane and a key component of the mitochondrial contact site and cristae junction organizing system (MICOS). Mic60 is critical for maintaining mitochondrial membrane structure and function. We previously demonstrated that mitochondrial Mic60 protein is susceptible to both covalent modification and loss in abundance following exposure to dopamine quinone. In this study, we utilized neuronally-differentiated SH-SY5Y and PC12 dopaminergic cell lines to examine the effects of altered Mic60 levels on mitochondrial function and cellular vulnerability in response to PD-relevant stressors. Short hairpin RNA (shRNA)-mediated knockdown of endogenous Mic60 protein in neuronal SH-SY5Y cells significantly potentiated dopamine-induced cell death, which was rescued by co-expressing shRNA-insensitive Mic60. Conversely, in PC12 and SH-SY5Y cells, Mic60 overexpression significantly attenuated both dopamine- and rotenone-induced cell death as compared to controls. Mic60 overexpression in SH-SY5Y cells was also associated with increased mitochondrial respiration, and, following rotenone exposure, increased spare respiratory capacity. Mic60 knockdown cells exhibited suppressed respiration and, following rotenone treatment, decreased spare respiratory capacity. Mic60 overexpression also affected mitochondrial fission/fusion dynamics. PC12 cells overexpressing Mic60 exhibited increased mitochondrial interconnectivity. Further, both PC12 cells and primary rat cortical neurons overexpressing Mic60 displayed suppressed mitochondrial fission and increased mitochondrial length in neurites. These results suggest that altering levels of Mic60 in dopaminergic neuronal cells significantly affects both mitochondrial homeostasis and cellular vulnerability to the PD-relevant stressors dopamine and rotenone, carrying implications for PD pathogenesis. PMID:27001148

[Landscape pattern and its vulnerability of Nansihu Lake basin during 1980-2015.

PubMed

Xui, Yan; Sun, Xiao Yin; Zhang, Da Zhi; Shan, Rui Feng; Liu, Fei

2018-02-01

Landscape pattern and its vulnerability have direct impacts on ecological environment in the basin. In order to protect the ecological security in Nansihu Lake basin, we analyzed the changes of landscape pattern based on seven sets of land use data (1980-2015), with landscape adaptability index (LAI) and landscape sensitivity index (LSI) being used to build the landscape vulnerability index (LVI). The spatial distribution and changes of LVI were analyzed. Results showed that the percentage of arable land areas decreased by 4.6% and construction land areas increased by 39.7% from 1980 to 2015. Other land use types showed fluctuating changes. The areas of forest land, grassland, and unused land decreased while water area increased. The arable land was the dominant land use type from 1980 to 2015 in this area. The degree of fragmentation of arable land and water area in the basin increased, whereas other land use types decreased. The fragmentation of whole basin decreased, but connectivity among landscape types enhanced. The irregularity and complexity of landscape pattern decreased, but diversity and evenness of landscape pattern displayed an increasing trend. With respect to LVI in different periods, the eastern part of the basin was higher than the western part, while the northern part was higher than the southern part. The spatial distribution of LVI was related to topography, layout of landscape types and change of land use. The LVI of Nansihu Lake basin showed a decline trend during 1980-2015. In the eastern part of the basin, higher level of LVI gradually dispersed and was replaced by lower level. In the northwest, the recovery of LVI was obvious. In the south and southwest parts, LVI was consistently low.

Trait-Like Vulnerability to Total and Partial Sleep Loss

PubMed Central

Rupp, Tracy L.; Wesensten, Nancy J.; Balkin, Thomas J.

2012-01-01

Objective: To determine the extent to which individual differences in vulnerability to total sleep deprivation also reflect individual differences in vulnerability to multiple nights of sleep restriction. Design: Two sleep loss conditions (order counterbalanced) separated by 2 to 4 weeks: (a) total sleep deprivation (TSD) of 2 nights (63 h continuous wakefulness); (b) sleep restriction (SR) of 7 nights of 3 h nightly time in bed (TIB). Both conditions were preceded by 7 in-laboratory nights with 10 h nightly TIB; and followed by 3 recovery nights with 8 h nightly TIB. Measures of cognitive performance (psychomotor vigilance, working memory [1-Back], and mathematical processing), objective alertness, subjective sleepiness, and mood were obtained at regular intervals under both conditions. Intra-class correlation coefficients (ICC) were computed using outcome metrics averaged over the last day (08:00-20:00) of TSD and SR. Setting: Residential sleep/performance testing facility. Participants: Nineteen healthy adults (ages 18-39; 11 males, 8 females). Interventions: 2 nights of TSD and 7 nights SR (3 h nightly TIB). Results: Volunteers who displayed greater vulnerability to TSD displayed greater vulnerability to SR on cognitive performance tasks (ICC: PVT lapses = 0.89; PVT speed = 0.86; 1-Back = 0.88; mathematical processing = 0.68, Ps < 0.05). In addition, trait-like responsivity to TSD/SR was found for mood variables vigor (ICC = 0.91), fatigue (ICC = 0.73), and happiness (ICC = 0.85) (all Ps < 0.05). Conclusion: Resilience to sleep loss is a trait-like characteristic that reflects an individual's ability to maintain performance during both types of sleep loss (SR and TSD). Whether the findings extend to sleep schedules other than those investigated here (63 h of TSD and 7 nights of 3 h nightly TIB) will be the focus of future studies. Citation: Rupp TL; Wesensten NJ; Balkin TJ. Trait-like vulnerability to total and partial sleep loss. SLEEP 2012;35(8):1163-1172. PMID:22851812

Contrasting water strategies of two Mediterranean shrubs of limited distribution: uncertain future under a drier climate.

PubMed

Lázaro-Nogal, Ana; Forner, Alicia; Traveset, Anna; Valladares, Fernando

2013-12-01

Plants have evolved different strategies to cope with drought, involving alternative ecophysiologies and different levels of plasticity. These strategies are critical for species of limited distribution, which are especially vulnerable to the current rates of rapid environmental change. The aim of this study was to assess the water strategy of two species with limited distribution, Cneorum tricoccon L. and Rhamnus ludovici-salvatoris Chodat., and evaluate their interpopulation variability along an aridity gradient to estimate their vulnerability to a drier climate. We measured different ecophysiological traits influenced by drought--stomatal conductance, maximum photochemical efficiency of photosynthesis II, carbon isotope ratio and chlorophyll concentration--in two climatically contrasting years, before and during summer drought. Both species were vulnerable to drought at the aridity limit of the gradient, but showed contrasting water strategies: while C. tricoccon was consistent in its water conservation strategy across the aridity gradient, R. ludovici-salvatoris was not, displaying higher and more variable stomatal conductances and being able to increase water-use efficiency at the most xeric sites. Changes in length and intensity of drought events may favor one species' strategy to the detriment of the other: C. tricoccon is more vulnerable to chronic and prolonged droughts, whereas short but acute droughts might have a stronger effect on R. ludovici-salvatoris. In those communities where these two species coexist, such different strategies might lead to changes in community structure under climate change scenarios, with unknown cascade effects on ecosystem functioning.

Facilitating climate change assessments by providing easy access to data and decision-support tools on-line

NASA Astrophysics Data System (ADS)

Bachelet, D. M.

2012-12-01

Public land managers are under increasing pressure to consider the potential impacts of climate change but they often lack access to the necessary scientific information and the support to interpret projections. Over 27% of the United States land area are designated as protected areas (e.g. National Parks and Wilderness Areas) including 76,900,000 ha of National Forests areas for which management plans need to be revised to prepare for climate change. Projections of warmer drier conditions raise concerns about extended summer drought, increased fire risks and potential pest/insect outbreaks threatening the carbon sequestration potential of the region as well as late summer water availability. Downscaled climate projections, soil vulnerability indices, and simulated climate change impacts on vegetation cover, fire frequency, carbon stocks, as well as species range shifts, have been uploaded in databasin.org to provide easy access to documented information that can be displayed, shared, and freely manipulated on line. We have uploaded NARCCAP scenarios and provided animations and time series display to look at regional and temporal trends in climate projections. We have uploaded simulation results of vegetation shifts from the global scale to local national parks and shared results with concerned managers. We have used combinations of vegetation models and niche models to evaluate wildlife resilience to future conditions. We have designed fuzzy logic models for ecological assessment projects and made them available on the Data Basin web site. We describe how we have used all this information to quantify climate change vulnerability for a variety of ecosystems, developing new web tools to provide comparative summaries of the various types of spatial and temporal data available for different regions.

Extreme rainfall, vulnerability and risk: a continental-scale assessment for South America

USGS Publications Warehouse

Vorosmarty, Charles J.; de Guenni, Lelys Bravo; Wollheim, Wilfred M.; Pellerin, Brian A.; Bjerklie, David M.; Cardoso, Manoel; D'Almeida, Cassiano; Colon, Lilybeth

2013-01-01

Extreme weather continues to preoccupy society as a formidable public safety concern bearing huge economic costs. While attention has focused on global climate change and how it could intensify key elements of the water cycle such as precipitation and river discharge, it is the conjunction of geophysical and socioeconomic forces that shapes human sensitivity and risks to weather extremes. We demonstrate here the use of high-resolution geophysical and population datasets together with documentary reports of rainfall-induced damage across South America over a multi-decadal, retrospective time domain (1960–2000). We define and map extreme precipitation hazard, exposure, affectedpopulations, vulnerability and risk, and use these variables to analyse the impact of floods as a water security issue. Geospatial experiments uncover major sources of risk from natural climate variability and population growth, with change in climate extremes bearing a minor role. While rural populations display greatest relative sensitivity to extreme rainfall, urban settings show the highest rates of increasing risk. In the coming decades, rapid urbanization will make South American cities the focal point of future climate threats but also an opportunity for reducing vulnerability, protecting lives and sustaining economic development through both traditional and ecosystem-based disaster risk management systems.

LOOKING INTO THE FUTURE OF A REGION

EPA Science Inventory

The U .S. EP A's Regional Vulnerability Assessment (ReVA) program addresses the latter phases of an integrated ecological risk assessment (U .S. EP A 1998) by building on available monitoring data, focusing on synthesizing information on spatial patterns, analyzing and displaying...

Automating Flood Hazard Mapping Methods for Near Real-time Storm Surge Inundation and Vulnerability Assessment

NASA Astrophysics Data System (ADS)

Weigel, A. M.; Griffin, R.; Gallagher, D.

2015-12-01

Storm surge has enough destructive power to damage buildings and infrastructure, erode beaches, and threaten human life across large geographic areas, hence posing the greatest threat of all the hurricane hazards. The United States Gulf of Mexico has proven vulnerable to hurricanes as it has been hit by some of the most destructive hurricanes on record. With projected rises in sea level and increases in hurricane activity, there is a need to better understand the associated risks for disaster mitigation, preparedness, and response. GIS has become a critical tool in enhancing disaster planning, risk assessment, and emergency response by communicating spatial information through a multi-layer approach. However, there is a need for a near real-time method of identifying areas with a high risk of being impacted by storm surge. Research was conducted alongside Baron, a private industry weather enterprise, to facilitate automated modeling and visualization of storm surge inundation and vulnerability on a near real-time basis. This research successfully automated current flood hazard mapping techniques using a GIS framework written in a Python programming environment, and displayed resulting data through an Application Program Interface (API). Data used for this methodology included high resolution topography, NOAA Probabilistic Surge model outputs parsed from Rich Site Summary (RSS) feeds, and the NOAA Census tract level Social Vulnerability Index (SoVI). The development process required extensive data processing and management to provide high resolution visualizations of potential flooding and population vulnerability in a timely manner. The accuracy of the developed methodology was assessed using Hurricane Isaac as a case study, which through a USGS and NOAA partnership, contained ample data for statistical analysis. This research successfully created a fully automated, near real-time method for mapping high resolution storm surge inundation and vulnerability for the Gulf of Mexico, and improved the accuracy and resolution of the Probabilistic Storm Surge model.

Social Vulnerability and Ebola Virus Disease in Rural Liberia.

PubMed

Stanturf, John A; Goodrick, Scott L; Warren, Melvin L; Charnley, Susan; Stegall, Christie M

2015-01-01

The Ebola virus disease (EVD) epidemic that has stricken thousands of people in the three West African countries of Liberia, Sierra Leone, and Guinea highlights the lack of adaptive capacity in post-conflict countries. The scarcity of health services in particular renders these populations vulnerable to multiple interacting stressors including food insecurity, climate change, and the cascading effects of disease epidemics such as EVD. However, the spatial distribution of vulnerable rural populations and the individual stressors contributing to their vulnerability are unknown. We developed a Social Vulnerability Classification using census indicators and mapped it at the district scale for Liberia. According to the Classification, we estimate that districts having the highest social vulnerability lie in the north and west of Liberia in Lofa, Bong, Grand Cape Mount, and Bomi Counties. Three of these counties together with the capital Monrovia and surrounding Montserrado and Margibi counties experienced the highest levels of EVD infections in Liberia. Vulnerability has multiple dimensions and a classification developed from multiple variables provides a more holistic view of vulnerability than single indicators such as food insecurity or scarcity of health care facilities. Few rural Liberians are food secure and many cannot reach a medical clinic in <80 minutes. Our results illustrate how census and household survey data, when displayed spatially at a sub-county level, may help highlight the location of the most vulnerable households and populations. Our results can be used to identify vulnerability hotspots where development strategies and allocation of resources to address the underlying causes of vulnerability in Liberia may be warranted. We demonstrate how social vulnerability index approaches can be applied in the context of disease outbreaks, and our methods are relevant elsewhere.

Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.

PubMed

Aldrin-Kirk, Patrick; Davidsson, Marcus; Holmqvist, Staffan; Li, Jia-Yi; Björklund, Tomas

2014-01-01

Synucleinopathies, characterized by intracellular aggregation of α-synuclein protein, share a number of features in pathology and disease progression. However, the vulnerable cell population differs significantly between the disorders, despite being caused by the same protein. While the vulnerability of dopamine cells in the substantia nigra to α-synuclein over-expression, and its link to Parkinson's disease, is well studied, animal models recapitulating the cortical degeneration in dementia with Lewy-bodies (DLB) are much less mature. The aim of this study was to develop a first rat model of widespread progressive synucleinopathy throughout the forebrain using adeno-associated viral (AAV) vector mediated gene delivery. Through bilateral injection of an AAV6 vector expressing human wild-type α-synuclein into the forebrain of neonatal rats, we were able to achieve widespread, robust α-synuclein expression with preferential expression in the frontal cortex. These animals displayed a progressive emergence of hyper-locomotion and dysregulated response to the dopaminergic agonist apomorphine. The animals receiving the α-synuclein vector displayed significant α-synuclein pathology including intra-cellular inclusion bodies, axonal pathology and elevated levels of phosphorylated α-synuclein, accompanied by significant loss of cortical neurons and a progressive reduction in both cortical and striatal ChAT positive interneurons. Furthermore, we found evidence of α-synuclein sequestered by IBA-1 positive microglia, which was coupled with a distinct change in morphology. In areas of most prominent pathology, the total α-synuclein levels were increased to, on average, two-fold, which is similar to the levels observed in patients with SNCA gene triplication, associated with cortical Lewy body pathology. This study provides a novel rat model of progressive cortical synucleinopathy, showing for the first time that cholinergic interneurons are vulnerable to α-synuclein over-expression. This animal model provides a powerful new tool for studies of neuronal degeneration in conditions of widespread cortical α-synuclein pathology, such as DLB, as well an attractive model for the exploration of novel biomarkers.

Serotonin transporter deficient mice are vulnerable to escape deficits following inescapable shocks.

PubMed

Muller, J M; Morelli, E; Ansorge, M; Gingrich, J A

2011-03-01

Modulation of serotonin transporter (5-HTT) function causes changes in affective behavior, both in humans and rodents. Stressful life events likewise affect emotional behavior. In humans, a low-expressing genetic 5-htt variant, the s allele of the 5-htt linked promoter region, has been associated with increased risk for depression only where there was a history of stressful life events. To investigate this gene by environment interaction in mice, we compared the effects of inescapable shocks on the behavior of wild-type (5-htt+/+), heterozygote (5-htt+/-) and serotonin transporter deficient (5-htt-/-) mice. Inescapable shocks induce behavioral changes including a shock escape deficit, in a subsequent test when escape is possible. Confirming a gene by environment interaction, we found that stress increases escape latencies in a gene-dose dependent manner (5-htt-/->5-htt+/->5-htt +/+), where as there were no differences among the genotypes in the unstressed condition. The vulnerability to increased escape latency could not be accounted for by enhanced fear learning, as 5-htt-/- mice did not show heightened fear conditioning. The interaction of 5-htt genotype and stress appeared to produce a selective behavioral vulnerability, because no interaction of 5-htt genotype and stress was observed in other measures of anxiety and depression-linked behavior, including the open field, novelty suppressed feeding, and forced swim tests. We replicated prior findings that the 5-htt-/- displays heightened anxiety and depression-like behavior at baseline (unstressed condition). In conclusion, our data offer the possibility for future investigation of the neural basis underlying 5-htt genotype-by-stress interaction shown here. © 2010 The Authors. Genes, Brain and Behavior © 2010 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.

Relationships between trait urgency, smoking reinforcement expectancies, and nicotine dependence

PubMed Central

Pang, Raina D.; Hom, Marianne S.; Geary, Bree A.; Doran, Neal; Spillane, Nichea S.; Guillot, Casey R.; Leventhal, Adam M.

2014-01-01

Urgency (i.e. the tendency to act rashly during negative/positive affect) may increase vulnerability to a variety of risky behaviors. This cross-sectional study of non-treatment-seeking smokers examined the relationship between urgency, level of nicotine dependence, and smoking reinforcement expectancies. Both positive and negative urgency were associated with nicotine dependence. Mediational analyses illustrated that smoking reinforcement expectancies significantly accounted for urgency-dependence relations, with negative reinforcement expectancies displaying incremental mediational effects. If replicated and extended, these findings may support the use of treatments that modify beliefs regarding smoking reinforcement outcomes as a means of buffering the risk of nicotine dependence carried by urgency. PMID:24784229

78 FR 14763 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-07

... States Department of Agriculture's (USDA) Special Supplemental Nutrition Program for Women, Infants and Children (WIC) serves a highly-vulnerable population low-income pregnant and post-partum women, infants... it displays a currently valid OMB control number. Food and Nutrition Service Title: WIC Infant and...

Selective Vulnerability of Striatal D2 versus D1 Dopamine Receptor-Expressing Medium Spiny Neurons in HIV-1 Tat Transgenic Male Mice.

PubMed

Schier, Christina J; Marks, William D; Paris, Jason J; Barbour, Aaron J; McLane, Virginia D; Maragos, William F; McQuiston, A Rory; Knapp, Pamela E; Hauser, Kurt F

2017-06-07

Despite marked regional differences in HIV susceptibility within the CNS, there has been surprisingly little exploration into the differential vulnerability among neuron types and the circuits they underlie. The dorsal striatum is especially susceptible, harboring high viral loads and displaying marked neuropathology, with motor impairment a frequent manifestation of chronic infection. However, little is known about the response of individual striatal neuron types to HIV or how this disrupts function. Therefore, we investigated the morphological and electrophysiological effects of HIV-1 trans -activator of transcription (Tat) in dopamine subtype 1 (D1) and dopamine subtype 2 (D2) receptor-expressing striatal medium spiny neurons (MSNs) by breeding transgenic Tat-expressing mice to Drd1a -tdTomato- or Drd2 -eGFP-reporter mice. An additional goal was to examine neuronal vulnerability early during the degenerative process to gain insight into key events underlying the neuropathogenesis. In D2 MSNs, exposure to HIV-1 Tat reduced dendritic spine density significantly, increased dendritic damage (characterized by swellings/varicosities), and dysregulated neuronal excitability (decreased firing at 200-300 pA and increased firing rates at 450 pA), whereas insignificant morphologic and electrophysiological consequences were observed in Tat-exposed D1 MSNs. These changes were concomitant with an increased anxiety-like behavioral profile (lower latencies to enter a dark chamber in a light-dark transition task, a greater frequency of light-dark transitions, and reduced rearing time in an open field), whereas locomotor behavior was unaffected by 2 weeks of Tat induction. Our findings suggest that D2 MSNs and a specific subset of neural circuits within the dorsal striatum are preferentially vulnerable to HIV-1. SIGNIFICANCE STATEMENT Despite combination antiretroviral therapy (cART), neurocognitive disorders afflict 30-50% of HIV-infected individuals and synaptodendritic injury remains evident in specific brain regions such as the dorsal striatum. A possible explanation for the sustained neuronal injury is that the neurotoxic HIV-1 regulatory protein trans -activator of transcription (Tat) continues to be expressed in virally suppressed patients on cART. Using inducible Tat-expressing transgenic mice, we found that dopamine subtype 2 (D2) receptor-expressing medium spiny neurons (MSNs) are selectively vulnerable to Tat exposure compared with D1 receptor-expressing MSNs. This includes Tat-induced reductions in D2 MSN dendritic spine density, increased dendritic damage, and disruptions in neuronal excitability, which coincide with elevated anxiety-like behavior. These data suggest that D2 MSNs and specific circuits within the basal ganglia are preferentially vulnerable to HIV-1. Copyright © 2017 the authors 0270-6474/17/375759-12$15.00/0.

Co-sensitivity to the incentive properties of palatable food and cocaine in rats; implications for co-morbid addictions.

PubMed

Levy, AnneMarie; Salamon, Avi; Tucci, Mark; Limebeer, Cheryl L; Parker, Linda A; Leri, Francesco

2013-09-01

Several lines of evidence suggest that there may be a shared vulnerability to acquire behaviors motivated by strong incentive stimuli. Non-food restricted male Sprague-Dawley rats (n = 78) underwent place conditioning with Oreos, and were subsequently tested on cocaine self-administration (SA) on fixed and progressive ratios, as well as extinction and reinstatement by cocaine primes and by consumption of Oreos. Although there was a group preference for the Oreo-paired compartment, at the individual level some rats (69%) displayed a preference and others did not. In cocaine SA, 'preference' rats achieved higher break points on a progressive ratio, and displayed greater responding during extinction and cocaine-induced reinstatement. Within the context of this study, Oreo-cocaine cross-reinstatement was not observed. In a control study, rats (n = 29) conditioned with a less palatable food (rice cakes) also displayed individual differences in place preference, but not on subsequent cocaine tests. These findings indicate that there is a relationship between incentive learning promoted by palatable foods and by cocaine. This supports the hypothesis that co-morbid food-drug addictions may result from a shared vulnerability to acquire behaviors motivated by strong incentives. © 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction.

Metformin directly acts on mitochondria to alter cellular bioenergetics

PubMed Central

2014-01-01

Background Metformin is widely used in the treatment of diabetes, and there is interest in ‘repurposing’ the drug for cancer prevention or treatment. However, the mechanism underlying the metabolic effects of metformin remains poorly understood. Methods We performed respirometry and stable isotope tracer analyses on cells and isolated mitochondria to investigate the impact of metformin on mitochondrial functions. Results We show that metformin decreases mitochondrial respiration, causing an increase in the fraction of mitochondrial respiration devoted to uncoupling reactions. Thus, cells treated with metformin become energetically inefficient, and display increased aerobic glycolysis and reduced glucose metabolism through the citric acid cycle. Conflicting prior studies proposed mitochondrial complex I or various cytosolic targets for metformin action, but we show that the compound limits respiration and citric acid cycle activity in isolated mitochondria, indicating that at least for these effects, the mitochondrion is the primary target. Finally, we demonstrate that cancer cells exposed to metformin display a greater compensatory increase in aerobic glycolysis than nontransformed cells, highlighting their metabolic vulnerability. Prevention of this compensatory metabolic event in cancer cells significantly impairs survival. Conclusions Together, these results demonstrate that metformin directly acts on mitochondria to limit respiration and that the sensitivity of cells to metformin is dependent on their ability to cope with energetic stress. PMID:25184038

Are car daytime running lights detrimental to motorcycle conspicuity?

PubMed

Cavallo, Viola; Pinto, Maria

2012-11-01

For a long time, motorcycles were the only vehicles with daytime running lights (DRLs), but this conspicuity advantage has been questioned due to the rapidly increasing introduction of DRLs on cars as well. The present experiment was designed to assess effects of car DRLs on motorcycle perception in a situation that specifically brought attentional conspicuity to bear. Photographs representing complex urban traffic scenes were displayed briefly (250 ms) to 24 participants who had to detect vulnerable road users (motorcyclists, cyclists, pedestrians) appearing at different locations and distances. Car DRLs hampered motorcycle perception compared to conditions where car lights were not on, especially when the motorcycle was at a greater distance from the observer and when it was located in the central part of the visual scene. Car DRLs also hampered the perception of cyclists and pedestrians. Although the globally positive safety effect of car DRLs is generally acknowledged, our study suggests that more attention should be paid to motorcyclists and other vulnerable road users when introducing car DRLs. Several means of improving motorcycle conspicuity in car DRL environments are discussed. Copyright © 2011 Elsevier Ltd. All rights reserved.

Migration in the Anthropocene: how collective navigation, environmental system and taxonomy shape the vulnerability of migratory species.

PubMed

Hardesty-Moore, Molly; Deinet, Stefanie; Freeman, Robin; Titcomb, Georgia C; Dillon, Erin M; Stears, Keenan; Klope, Maggie; Bui, An; Orr, Devyn; Young, Hillary S; Miller-Ter Kuile, Ana; Hughey, Lacey F; McCauley, Douglas J

2018-05-19

Recent increases in human disturbance pose significant threats to migratory species using collective movement strategies. Key threats to migrants may differ depending on behavioural traits (e.g. collective navigation), taxonomy and the environmental system (i.e. freshwater, marine or terrestrial) associated with migration. We quantitatively assess how collective navigation, taxonomic membership and environmental system impact species' vulnerability by (i) evaluating population change in migratory and non-migratory bird, mammal and fish species using the Living Planet Database (LPD), (ii) analysing the role of collective navigation and environmental system on migrant extinction risk using International Union for Conservation of Nature (IUCN) classifications and (iii) compiling literature on geographical range change of migratory species. Likelihood of population decrease differed by taxonomic group: migratory birds were more likely to experience annual declines than non-migrants, while mammals displayed the opposite pattern. Within migratory species in IUCN, we observed that collective navigation and environmental system were important predictors of extinction risk for fishes and birds, but not for mammals, which had overall higher extinction risk than other taxa. We found high phylogenetic relatedness among collectively navigating species, which could have obscured its importance in determining extinction risk. Overall, outputs from these analyses can help guide strategic interventions to conserve the most vulnerable migrations.This article is part of the theme issue 'Collective movement ecology'. © 2018 The Author(s).

Susceptibility to traumatic stress sensitizes the dopaminergic response to cocaine and increases motivation for cocaine.

PubMed

Brodnik, Zachary D; Black, Emily M; Clark, Meagan J; Kornsey, Kristen N; Snyder, Nathaniel W; España, Rodrigo A

2017-10-01

Patients with post-traumatic stress disorder have a heightened vulnerability to developing substance use disorders; however, the biological underpinnings of this vulnerability remain unresolved. We used the predator odor stress model of post-traumatic stress disorder with segregation of subjects as susceptible or resilient based on elevated plus maze behavior and context avoidance. We then determined behavioral and neurochemical differences across susceptible, resilient, and control populations using a panel of behavioral and neurochemical assays. Susceptible subjects showed a significant increase in the motoric and dopaminergic effects of cocaine, and this corresponded with heightened motivation to self-administer cocaine. Resilient subjects did not show differences in the motoric effects of cocaine, in dopamine signaling in vivo, or in any measure of cocaine self-administration. Nonetheless, we found that these animals displayed elevations in both the dopamine release-promoting effects of cocaine and dopamine autoreceptor sensitivity ex vivo. Our results suggest that the experience of traumatic stress may produce alterations in dopamine systems that drive elevations in cocaine self-administration behavior in susceptible subjects, but may also produce both active and passive forms of resilience that function to prevent gross changes in cocaine's reinforcing efficacy in resilient subjects. Copyright © 2017 Elsevier Ltd. All rights reserved.

Protecting clinical data on Web client computers: the PCASSO approach.

PubMed Central

Masys, D. R.; Baker, D. B.

1998-01-01

The ubiquity and ease of use of the Web have made it an increasingly popular medium for communication of health-related information. Web interfaces to commercially available clinical information systems are now available or under development by most major vendors. To the extent that such interfaces involve the use of unprotected operating systems, they are vulnerable to security limitations of Web client software environments. The Patient Centered Access to Secure Systems Online (PCASSO) project extends the protections for person-identifiable health data on Web client computers. PCASSO uses several approaches, including physical protection of authentication information, execution containment, graphical displays, and monitoring the client system for intrusions and co-existing programs that may compromise security. PMID:9929243

Perceptions of submissiveness: implications for victimization.

PubMed

Richards, L; Rollerson, B; Phillips, J

1991-07-01

Some researchers have suggested that a precondition of affective submissiveness may increase the likelihood of female victimization in sexual assault, whereas others have suggested that criminal offenders use perceptions of vulnerability when selecting a victim. In this study, based on American college students, men (decoders) rated videotaped women (encoders) dominant versus submissive using a semantic differential instrument. Cue evaluators analyzed the body language and appearance of the videotaped women using a Likert instrument. The results suggest that (a) men form differentiated perceptions of dominant versus submissive women, (b) such perceptions substantially rely on nonverbal cues, (c) dominant and submissive women display visually different behaviors and appearances, and (d) men tend to select submissive females for exploitation.

Sex and Genes, Part 1: Sexuality and down, Prader-Willi, and Williams Syndromes

ERIC Educational Resources Information Center

Watson, Shelley Lynn; Richards, Deborah A.; Miodrag, Nancy; Fedoroff, J. Paul

2012-01-01

Specific genetic syndromes affect individuals' sexual development, experiences, and fertility. Individuals with specific syndromes can also display inappropriate sexual behavior resulting from vulnerabilities presented by their genetic makeup. Using clinical case studies, we discuss the specific impact that Down, Prader-Willi, and Williams…

RAND Review. Volume 28, Number 2, Summer 2004

DTIC Science & Technology

2004-01-01

received an average of 23 percent district of Tijuana , more for unprotected sex (and up to 46 percent more if Mexico, displays the workers were judged...management. "Improvement in access to medica - eral ways, according to the reports. Vulnerable elders tions without quality assurance may result in a mere

Fetal alcohol exposure increases susceptibility to carcinogenesis and promotes tumor progression in prostate gland.

PubMed

Sarkar, Dipak K

2015-01-01

The idea that exposure to adverse environmental conditions and lifestyle choices during pregnancy can result in fetal programming that underlies disease susceptibility in adulthood is now widely accepted. Fetal alcohol exposed offspring displays many behavioral and physiological abnormalities including neuroendocrine-immune functions, which often carry over into their adult life. Since the neuroendocrine-immune system plays an important role in controlling tumor surveillance, fetal alcohol exposed offspring can be vulnerable to develop cancer. Animal studies have recently showed increased cancer growth and progression in various tissues of fetal alcohol exposed offspring. I will detail in this chapter the recent evidence for increased prostate carcinogenesis in fetal alcohol exposed rats. I will also provide evidence for a role of excessive estrogenization during prostatic development in the increased incidence of prostatic carcinoma in these animals. Furthermore, I will discuss the additional possibility of the involvement of impaired stress regulation and resulting immune incompetence in the increased prostatic neoplasia in the fetal alcohol exposed offspring.

Pain vulnerability and DNA methyltransferase 3a involved in the affective dimension of chronic pain

PubMed Central

Wang, Wei; Li, Caiyue; Cai, Youqing; Pan, Zhizhong Z

2017-01-01

Chronic pain with comorbid emotional disorders is a prevalent neurological disease in patients under various pathological conditions, yet patients show considerable difference in their vulnerability to developing chronic pain. Understanding the neurobiological basis underlying this pain vulnerability is essential to develop targeted therapies of higher efficiency in pain treatment of precision medicine. However, this pain vulnerability has not been addressed in preclinical pain research in animals to date. In this study, we investigated individual variance in both sensory and affective/emotional dimensions of pain behaviors in response to chronic neuropathic pain condition in a mouse model of chronic pain. We found that mice displayed considerably diverse sensitivities in the chronic pain-induced anxiety- and depression-like behaviors of affective pain. Importantly, the mouse group that was more vulnerable to developing anxiety was also more vulnerable to developing depressive behavior under the chronic pain condition. In contrast, there was relatively much less variance in individual responses in the sensory dimension of pain sensitization. Molecular analysis revealed that those mice vulnerable to developing the emotional disorders showed a significant reduction in the protein level of DNA methyltransferase 3a in the emotion-processing central nucleus of the amygdala. In addition, social stress also revealed significant individual variance in anxiety behavior in mice. These findings suggest that individual pain vulnerability may be inherent mostly in the emotional/affective component of chronic pain and remain consistent in different aspects of negative emotion, in which adaptive changes in the function of DNA methyltransferase 3a for DNA methylation in central amygdala may play an important role. This may open a new avenue of basic research into the neurobiological mechanisms underlying pain vulnerability. PMID:28849714

Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice

PubMed Central

Papaleo, Francesco; Silverman, Jill L.; Aney, Jordan; Tian, Qingjun; Barkan, Charlotte L.; Chadman, Kathryn K.; Crawley, Jacqueline N.

2011-01-01

BDNF regulates components of cognitive processes and has been implicated in psychiatric disorders. Here we report that genetic overexpression of the BDNF mature isoform (BDNF-tg) in female mice impaired working memory functions while sparing components of fear conditioning. BDNF-tg mice also displayed reduced breeding efficiency, higher anxiety-like scores, high self-grooming, impaired prepulse inhibition, and higher susceptibility to seizures when placed in a new empty cage, as compared with wild-type (WT) littermate controls. Control measures of general health, locomotor activity, motor coordination, depression-related behaviors, and sociability did not differ between genotypes. The present findings, indicating detrimental effects of life-long increased BDNF in mice, may inform human studies evaluating the role of BDNF functional genetic variations on cognitive abilities and vulnerability to psychiatric disorders. PMID:21791566

Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801.

PubMed

Farley, Séverine; Dumas, Sylvie; El Mestikawy, Salah; Giros, Bruno

2012-01-01

Major depression is a chronic psychiatric illness that is highly prevalent and disabling. The available medications are ineffective for many patients suggesting that differents molecular pathways could be specifically altered in the unresponsive patients. Recently, the glutamatergic system has emerged as a target in the research on depression and acute NMDA receptor blockade has been shown to produce strong antidepressant effects. We have studied the adaptations of four mice strains (C57BL/6, DBA/2, C3H and BALB/c) to a chronic unpredictable stress protocol, a widely used model of depression in rodents. BALB/c mice displayed strikingly different behavioral and neurochemical adaptations compared to the other strains tested, suggesting that different molecular pathways are involved in their specific vulnerability. They became hyperactive during the dark period, anhedonic-like and displayed no alterations in the tail suspension test (TST). After chronic stress, only the BALB/c displayed an increased frontocortical VGLUT1 expression which is suggestive of a dysregulation of their prefrontal glutamatergic system, and no BDNF mRNA alteration, although the acute stress modulation of this mRNA is similar to the other strains. Chronic administration of an antagonist of NMDA receptors, MK-801, induced antidepressant-like effects in the TST for stressed BALB/c, but was ineffective for the hyperactivity and anhedonia-like behavior, in contrast to fluoxetine. Chronic MK-801 was totally inactive on the behavior of stressed C57BL/6 mice. MK-801, but not fluoxetine, inhibited the VGLUT1 prefrontal increase in BALB/c. Fluoxetine increased VGLUT1 and BDNF mRNA expression in the hippocampus of the C57BL/6 but not in the BALB/c strain, suggesting a different reactivity in-between strain to both stress and antidepressant. Interestingly enough, the BDNF or VGLUT1 increase is not necessary to reverse the stress induced behavioral alterations in our experimental settings. This observation supports the conclusion that BDNF and VGLUT1 are depressive state markers, but not involved in its etiology. Finally, there is a substantial similarity between the phenotypes that are observed in the BALB/c mice and endogenous depression in humans, as well as between C57BL/6 mice and atypical depression. To have a better understanding of the variability of depression etiologies in human, and the implication of the glutamatergic system, it may be suggested that future animal studies in the mouse would systematically compare the two strains BALB/c and C57BL/6 for the identification of relevant biological mechanisms. This article is part of a special Issue entitled 'Anxiety and Depression'. Copyright © 2011 Elsevier Ltd. All rights reserved.

[Effects of land use change on landscape pattern vulnerability in Yinchuan Basin, Northwest China].

PubMed

Ren, Zhi-yuan; Zhang, Han

2016-01-01

Landscape pattern vulnerability reflects the instability and sensitivity of ecological system to external disturbances and helps to understand the status and trend of ecological environment. This paper used landscape sensitivity index and landscape adaptability index to construct the landscape pattern vulnerability index of Yinchuan Basin, and got the distribution of the landscape pattern vulnerability in 2001 and 2013. Our study explored the effect of the land use degree composite index, the integrated land use dynamic degree, the importance index of land use change and various types of land transfer on landscape pattern vulnerability. Results showed that the land use degree composite index was mainly caused by the increase of the arable land, forest and the construction land. The higher proportion of the arable land or forest, the lower the vulnerability was, and the construction land had the opposite effect. With the increase of integrated land use dynamic degree, the construction land significantly increased the vulnerability, followed by grassland, and the forest significantly decreased the vulnerability, followed by the arable land. As the importance index of land use change increasing, the arable land could significantly decrease the vulnerability, followed by the forest, the grassland had a weaker trend with no obvious pattern, and the construction land significantly increased the vulnerability. When the arable land, forest and the grassland were the maintypes of land use transfer, the increasing proportion of the construction land increased the vulnerability. When the construction land was the main type of land use transfer, the grassland and forest improved the vulnerability and the arable land had the opposite effect. Changes in the number of land use types influenced the spatial structure of land use to a certain extent, which could offer a reference on using and developing the land resources scientifically. The ternary diagram could reflect the impact of various types of and use change on the landscape vulnerability, which diagram enriched the content of the research on the land use and change.

Data management for geospatial vulnerability assessment of interdependencies in US power generation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shih, C.Y.; Scown, C.D.; Soibelman, L.

2009-09-15

Critical infrastructures maintain our society's stability, security, and quality of life. These systems are also interdependent, which means that the disruption of one infrastructure system can significantly impact the operation of other systems. Because of the heavy reliance on electricity production, it is important to assess possible vulnerabilities. Determining the source of these vulnerabilities can provide insight for risk management and emergency response efforts. This research uses data warehousing and visualization techniques to explore the interdependencies between coal mines, rail transportation, and electric power plants. By merging geospatial and nonspatial data, we are able to model the potential impacts ofmore » a disruption to one or more mines, rail lines, or power plants, and visually display the results using a geographical information system. A scenario involving a severe earthquake in the New Madrid Seismic Zone is used to demonstrate the capabilities of the model when given input in the form of a potentially impacted area. This type of interactive analysis can help decision makers to understand the vulnerabilities of the coal distribution network and the potential impact it can have on electricity production.« less

Immersive Input Display Device (I2D2) for tactical information viewing

NASA Astrophysics Data System (ADS)

Tremper, David E.; Burnett, Kevin P.; Malloy, Andrew R.; Wert, Robert

2006-05-01

Daylight readability of hand-held displays has been an ongoing issue for both commercial and military applications. In an effort to reduce the effects of ambient light on the readability of military displays, the Naval Research Laboratory (NRL) began investigating and developing advanced hand-held displays. Analysis and research of display technologies with consideration for vulnerability to environmental conditions resulted in the complete design and fabrication of the hand-held Immersive Input Display Device (I2D2) monocular. The I2D2 combines an Organic Light Emitting Diode (OLED) SVGA+ micro-display developed by eMagin Corporation with an optics configuration inside a cylindrical housing. A rubber pressure-eyecup allows view ability only when the eyecup is depressed, eliminating light from both entering and leaving the device. This feature allows the I2D2 to be used during the day, while not allowing ambient light to affect the readability. It simultaneously controls light leakage, effectively eliminating the illumination, and thus preserving the tactical position, of the user in the dark. This paper will examine the characteristics and introduce the design of the I2D2.

Linking Ecology and Epidemiology to Understand Predictors of Multi-Host Responses to an Emerging Pathogen, the Amphibian Chytrid Fungus

PubMed Central

Stephens, Patrick R.; Hua, Jessica; Searle, Catherine L.; Xie, Gisselle Yang; Urbina, Jenny; Olson, Deanna H.; Bancroft, Betsy A.; Weis, Virginia; Hammond, John I.; Relyea, Rick A.; Blaustein, Andrew R.

2017-01-01

Variation in host responses to pathogens can have cascading effects on populations and communities when some individuals or groups of individuals display disproportionate vulnerability to infection or differ in their competence to transmit infection. The fungal pathogen, Batrachochytrium dendrobatidis (Bd) has been detected in almost 700 different amphibian species and is implicated in numerous global amphibian population declines. Identifying key hosts in the amphibian-Bd system–those who are at greatest risk or who pose the greatest risk for others–is challenging due in part to many extrinsic environmental factors driving spatiotemporal Bd distribution and context-dependent host responses to Bd in the wild. One way to improve predictive risk models and generate testable mechanistic hypotheses about vulnerability is to complement what we know about the spatial epidemiology of Bd with data collected through comparative experimental studies. We used standardized pathogen challenges to quantify amphibian survival and infection trajectories across 20 post-metamorphic North American species raised from eggs. We then incorporated trait-based models to investigate the predictive power of phylogenetic history, habitat use, and ecological and life history traits in explaining responses to Bd. True frogs (Ranidae) displayed the lowest infection intensities, whereas toads (Bufonidae) generally displayed the greatest levels of mortality after Bd exposure. Affiliation with ephemeral aquatic habitat and breadth of habitat use were strong predictors of vulnerability to and intensity of infection and several other traits including body size, lifespan, age at sexual maturity, and geographic range also appeared in top models explaining host responses to Bd. Several of the species examined are highly understudied with respect to Bd such that this study represents the first experimental susceptibility data. Combining insights gained from experimental studies with observations of landscape-level disease prevalence may help explain current and predict future pathogen dynamics in the Bd system. PMID:28095428

Linking Ecology and Epidemiology to Understand Predictors of Multi-Host Responses to an Emerging Pathogen, the Amphibian Chytrid Fungus.

PubMed

Gervasi, Stephanie S; Stephens, Patrick R; Hua, Jessica; Searle, Catherine L; Xie, Gisselle Yang; Urbina, Jenny; Olson, Deanna H; Bancroft, Betsy A; Weis, Virginia; Hammond, John I; Relyea, Rick A; Blaustein, Andrew R

2017-01-01

Variation in host responses to pathogens can have cascading effects on populations and communities when some individuals or groups of individuals display disproportionate vulnerability to infection or differ in their competence to transmit infection. The fungal pathogen, Batrachochytrium dendrobatidis (Bd) has been detected in almost 700 different amphibian species and is implicated in numerous global amphibian population declines. Identifying key hosts in the amphibian-Bd system-those who are at greatest risk or who pose the greatest risk for others-is challenging due in part to many extrinsic environmental factors driving spatiotemporal Bd distribution and context-dependent host responses to Bd in the wild. One way to improve predictive risk models and generate testable mechanistic hypotheses about vulnerability is to complement what we know about the spatial epidemiology of Bd with data collected through comparative experimental studies. We used standardized pathogen challenges to quantify amphibian survival and infection trajectories across 20 post-metamorphic North American species raised from eggs. We then incorporated trait-based models to investigate the predictive power of phylogenetic history, habitat use, and ecological and life history traits in explaining responses to Bd. True frogs (Ranidae) displayed the lowest infection intensities, whereas toads (Bufonidae) generally displayed the greatest levels of mortality after Bd exposure. Affiliation with ephemeral aquatic habitat and breadth of habitat use were strong predictors of vulnerability to and intensity of infection and several other traits including body size, lifespan, age at sexual maturity, and geographic range also appeared in top models explaining host responses to Bd. Several of the species examined are highly understudied with respect to Bd such that this study represents the first experimental susceptibility data. Combining insights gained from experimental studies with observations of landscape-level disease prevalence may help explain current and predict future pathogen dynamics in the Bd system.

Inflammation and vascular remodeling in the ventral hippocampus contributes to vulnerability to stress.

PubMed

Pearson-Leary, J; Eacret, D; Chen, R; Takano, H; Nicholas, B; Bhatnagar, S

2017-06-27

During exposure to chronic stress, some individuals engage in active coping behaviors that promote resiliency to stress. Other individuals engage in passive coping that is associated with vulnerability to stress and with anxiety and depression. In an effort to identify novel molecular mechanisms that underlie vulnerability or resilience to stress, we used nonbiased analyses of microRNAs in the ventral hippocampus (vHPC) to identify those miRNAs differentially expressed in active (long-latency (LL)/resilient) or passive (short-latency (SL)/vulnerable) rats following chronic social defeat. In the vHPC of active coping rats, miR-455-3p level was increased, while miR-30e-3p level was increased in the vHPC of passive coping rats. Pathway analyses identified inflammatory and vascular remodeling pathways as enriched by genes targeted by these microRNAs. Utilizing several independent markers for blood vessels, inflammatory processes and neural activity in the vHPC, we found that SL/vulnerable rats exhibit increased neural activity, vascular remodeling and inflammatory processes that include both increased blood-brain barrier permeability and increased number of microglia in the vHPC relative to control and resilient rats. To test the relevance of these changes for the development of the vulnerable phenotype, we used pharmacological approaches to determine the contribution of inflammatory processes in mediating vulnerability and resiliency. Administration of the pro-inflammatory cytokine vascular endothelial growth factor-164 increased vulnerability to stress, while the non-steroidal anti-inflammatory drug meloxicam attenuated vulnerability. Collectively, these results show that vulnerability to stress is determined by a re-designed neurovascular unit characterized by increased neural activity, vascular remodeling and pro-inflammatory mechanisms in the vHPC. These results suggest that dampening inflammatory processes by administering anti-inflammatory agents reduces vulnerability to stress. These results have translational relevance as they suggest that administration of anti-inflammatory agents may reduce the impact of stress or trauma in vulnerable individuals.

Inflammation and vascular remodeling in the ventral hippocampus contributes to vulnerability to stress

PubMed Central

Pearson-Leary, J; Eacret, D; Chen, R; Takano, H; Nicholas, B; Bhatnagar, S

2017-01-01

During exposure to chronic stress, some individuals engage in active coping behaviors that promote resiliency to stress. Other individuals engage in passive coping that is associated with vulnerability to stress and with anxiety and depression. In an effort to identify novel molecular mechanisms that underlie vulnerability or resilience to stress, we used nonbiased analyses of microRNAs in the ventral hippocampus (vHPC) to identify those miRNAs differentially expressed in active (long-latency (LL)/resilient) or passive (short-latency (SL)/vulnerable) rats following chronic social defeat. In the vHPC of active coping rats, miR-455-3p level was increased, while miR-30e-3p level was increased in the vHPC of passive coping rats. Pathway analyses identified inflammatory and vascular remodeling pathways as enriched by genes targeted by these microRNAs. Utilizing several independent markers for blood vessels, inflammatory processes and neural activity in the vHPC, we found that SL/vulnerable rats exhibit increased neural activity, vascular remodeling and inflammatory processes that include both increased blood–brain barrier permeability and increased number of microglia in the vHPC relative to control and resilient rats. To test the relevance of these changes for the development of the vulnerable phenotype, we used pharmacological approaches to determine the contribution of inflammatory processes in mediating vulnerability and resiliency. Administration of the pro-inflammatory cytokine vascular endothelial growth factor-164 increased vulnerability to stress, while the non-steroidal anti-inflammatory drug meloxicam attenuated vulnerability. Collectively, these results show that vulnerability to stress is determined by a re-designed neurovascular unit characterized by increased neural activity, vascular remodeling and pro-inflammatory mechanisms in the vHPC. These results suggest that dampening inflammatory processes by administering anti-inflammatory agents reduces vulnerability to stress. These results have translational relevance as they suggest that administration of anti-inflammatory agents may reduce the impact of stress or trauma in vulnerable individuals. PMID:28654094

Disrupted social development enhances the motivation for cocaine in rats.

PubMed

Baarendse, Petra J J; Limpens, Jules H W; Vanderschuren, Louk J M J

2014-04-01

Early social experiences are of major importance for behavioural development. In particular, social play behaviour during post-weaning development is thought to facilitate the attainment of social, emotional and cognitive capacities. Conversely, social insults during development can cause long-lasting behavioural impairments and increase the vulnerability for psychiatric disorders, such as drug addiction. The aim of this study was to investigate whether a lack of social experiences during the juvenile and early adolescent stage, when social play behaviour is highly abundant, alters cocaine self-administration in rats. Rats were socially isolated from postnatal days 21 to 42 followed by re-socialization until adulthood. Cocaine self-administration was then assessed under a fixed ratio and progressive ratio schedule of reinforcement. Next, cue, cocaine and stress-induced reinstatement of cocaine seeking was determined following extinction of self-administration. Early social isolation resulted in an enhanced acquisition of self-administration of a low dose (0.083 mg/infusion) of cocaine, but the sensitivity to cocaine reinforcement, assessed using a dose-response analysis, was not altered in isolated rats. Moreover, isolated rats displayed an increased motivation for cocaine under a progressive ratio schedule of reinforcement. Extinction and reinstatement of cocaine seeking was not affected by early social isolation. Early social isolation causes a long-lasting increase in the motivation to self-administer cocaine. Thus, aberrations in post-weaning social development, such as the absence of social play, enhance the vulnerability for drug addiction later in life.

Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy

PubMed Central

Boyd, Penelope J.; Shorrock, Hannah K.; Carter, Roderick N.; Powis, Rachael A.; Thomson, Sophie R.; Thomson, Derek; Graham, Laura C.; Motyl, Anna A. L.; Highley, J. Robin; Becker, Thomas; Becker, Catherina G.; Heath, Paul R.

2017-01-01

Degeneration and loss of lower motor neurons is the major pathological hallmark of spinal muscular atrophy (SMA), resulting from low levels of ubiquitously-expressed survival motor neuron (SMN) protein. One remarkable, yet unresolved, feature of SMA is that not all motor neurons are equally affected, with some populations displaying a robust resistance to the disease. Here, we demonstrate that selective vulnerability of distinct motor neuron pools arises from fundamental modifications to their basal molecular profiles. Comparative gene expression profiling of motor neurons innervating the extensor digitorum longus (disease-resistant), gastrocnemius (intermediate vulnerability), and tibialis anterior (vulnerable) muscles in mice revealed that disease susceptibility correlates strongly with a modified bioenergetic profile. Targeting of identified bioenergetic pathways by enhancing mitochondrial biogenesis rescued motor axon defects in SMA zebrafish. Moreover, targeting of a single bioenergetic protein, phosphoglycerate kinase 1 (Pgk1), was found to modulate motor neuron vulnerability in vivo. Knockdown of pgk1 alone was sufficient to partially mimic the SMA phenotype in wild-type zebrafish. Conversely, Pgk1 overexpression, or treatment with terazosin (an FDA-approved small molecule that binds and activates Pgk1), rescued motor axon phenotypes in SMA zebrafish. We conclude that global bioenergetics pathways can be therapeutically manipulated to ameliorate SMA motor neuron phenotypes in vivo. PMID:28426667

Sense and sensitivity: responsiveness to offspring signals varies with the parents' potential to breed again

PubMed Central

Thorogood, Rose; Ewen, John G.; Kilner, Rebecca M.

2011-01-01

How sensitive should parents be to the demands of their young? Offspring are under selection to seek more investment than is optimal for parents to supply, which makes parents vulnerable to losing future fitness by responding to manipulative displays. Yet, parents cannot afford to ignore begging and risk allocating resources inefficiently. Here, we show that parents may solve this problem by adjusting their sensitivity to begging behaviour in relation to their own likelihood of breeding again, a factor largely neglected in previous analyses of parent–offspring interactions. In two carotenoid-supplementation experiments on a New Zealand passerine, the hihi Notiomystis cincta, we supplemented adults to enhance their propensity to breed again, and supplemented entire broods to increase their mouth colour, thus enhancing their solicitation display. We found that adults that attempted two breeding attempts a season were largely insensitive to the experimentally carotenoid-rich gapes of their brood, whereas those that bred just once responded by increasing their rate of provisioning at the nest. Our results show that parents can strategically vary their sensitivity to begging in relation to their future reproductive potential. By restricting opportunities for offspring to influence provisioning decisions, parents greatly limit the potential for offspring to win parent–offspring conflict. PMID:21270035

Partial Genetic Deletion of Neuregulin 1 Modulates the Effects of Stress on Sensorimotor Gating, Dendritic Morphology, and HPA Axis Activity in Adolescent Mice

PubMed Central

Chohan, Tariq W.; Boucher, Aurelie A.; Spencer, Jarrah R.; Kassem, Mustafa S.; Hamdi, Areeg A.; Karl, Tim; Fok, Sandra Y.; Bennett, Maxwell R.; Arnold, Jonathon C.

2014-01-01

Stress has been linked to the pathogenesis of schizophrenia. Genetic variation in neuregulin 1 (NRG1) increases the risk of developing schizophrenia and may help predict which high-risk individuals will transition to psychosis. NRG1 also modulates sensorimotor gating, a schizophrenia endophenotype. We used an animal model to demonstrate that partial genetic deletion of Nrg1 interacts with stress to promote neurobehavioral deficits of relevance to schizophrenia. Nrg1 heterozygous (HET) mice displayed greater acute stress-induced anxiety-related behavior than wild-type (WT) mice. Repeated stress in adolescence disrupted the normal development of higher prepulse inhibition of startle selectively in Nrg1 HET mice but not in WT mice. Further, repeated stress increased dendritic spine density in pyramidal neurons of the medial prefrontal cortex (mPFC) selectively in Nrg1 HET mice. Partial genetic deletion of Nrg1 also modulated the adaptive response of the hypothalamic-pituitary-adrenal axis to repeated stress, with Nrg1 HET displaying a reduced repeated stress-induced level of plasma corticosterone than WT mice. Our results demonstrate that Nrg1 confers vulnerability to repeated stress-induced sensorimotor gating deficits, dendritic spine growth in the mPFC, and an abberant endocrine response in adolescence. PMID:24442851

Linking ecology and epidemiology to understand predictors of multi-host responses to an emerging pathogen, the amphibian chytrid fungus

Treesearch

Stephanie S. Gervasi; Patrick R. Stephens; Jessica Hua; Catherine L. Searle; Gisselle Yang Xie; Jenny Urbina; Deanna H. Olson; Betsy A. Bancroft; Virginia Weis; John I. Hammond; Rick A. Relyea; Andrew R. Blaustein; Stefan Lötters

2017-01-01

Variation in host responses to pathogens can have cascading effects on populations and communities when some individuals or groups of individuals display disproportionate vulnerability to infection or differ in their competence to transmit infection. The fungal pathogen, Batrachochytrium dendrobatidis (Bd) has been detected in almost 700 different...

When Errors Count: An EEG Study on Numerical Error Monitoring under Performance Pressure

ERIC Educational Resources Information Center

Schillinger, Frieder L.; De Smedt, Bert; Grabner, Roland H.

2016-01-01

In high-stake tests, students often display lower achievements than expected based on their skill level--a phenomenon known as choking under pressure. This imposes a serious problem for many students, especially for test-anxious individuals. Among school subjects, mathematics has been shown to be particularly vulnerable to choking. To succeed in a…

Second Breakdown of 18V Grounded Gate NMOS induced by the Kirk Effect under Electrostatic Discharge

NASA Astrophysics Data System (ADS)

Jeon, Byung-Chul; Lee, Seung-Chul; Han, Min-Koo

2003-09-01

Electrostatic Discharge (ESD) failure mechanisms of 18V grounded gate NMOS (GGNMOS) for liquid crystal display driver IC (LDI) applications are investigated and effects of layout design parameters on the ESD immunity level are analyzed. Experimental results show that 18V GGNMOS exhibits snapback characteristics and the ESD immunity level is rather high when XO (N-drift overlap over n+ source/drain) is sufficiently large, while GGNMOS does not exhibit the sustaining region and is very vulnerable to ESD stress when XO is relatively small. Simulation results show that the ESD failure mechanism of 18V GGNMOS could be the low-temperature second breakdown induced by the Kirk effect. It is inferred that a certain amount of XO is indispensable to ensure snapback characteristics and high ESD immunity level. Simulation results also show that the ESD immunity level is increased as drain contact to gate space (DCGS) is increased.

A relative vulnerability estimation of flood disaster using data envelopment analysis in the Dongting Lake region of Hunan

NASA Astrophysics Data System (ADS)

Li, C.-H.; Li, N.; Wu, L.-C.; Hu, A.-J.

2013-07-01

The vulnerability to flood disaster is addressed by a number of studies. It is of great importance to analyze the vulnerability of different regions and various periods to enable the government to make policies for distributing relief funds and help the regions to improve their capabilities against disasters, yet a recognized paradigm for such studies seems missing. Vulnerability is defined and evaluated through either physical or economic-ecological perspectives depending on the field of the researcher concerned. The vulnerability, however, is the core of both systems as it entails systematic descriptions of flood severities or disaster management units. The research mentioned often has a development perspective, and in this article we decompose the overall flood system into several factors: disaster driver, disaster environment, disaster bearer, and disaster intensity, and take the interaction mechanism among all factors as an indispensable function. The conditions of flood disaster components are demonstrated with disaster driver risk level, disaster environment stability level and disaster bearer sensitivity, respectively. The flood system vulnerability is expressed as vulnerability = f(risk, stability, sensitivity). Based on the theory, data envelopment analysis method (DEA) is used to detail the relative vulnerability's spatiotemporal variation of a flood disaster system and its components in the Dongting Lake region. The study finds that although a flood disaster system's relative vulnerability is closely associated with its components' conditions, the flood system and its components have a different vulnerability level. The overall vulnerability is not the aggregation of its components' vulnerability. On a spatial scale, zones central and adjacent to Dongting Lake and/or river zones are characterized with very high vulnerability. Zones with low and very low vulnerability are mainly distributed in the periphery of the Dongting Lake region. On a temporal scale, the occurrence of a vibrating flood vulnerability trend is observed. A different picture is displayed with the disaster driver risk level, disaster environment stability level and disaster bearer sensitivity level. The flood relative vulnerability estimation method based on DEA is characteristic of good comparability, which takes the relative efficiency of disaster system input-output into account, and portrays a very diverse but consistent picture with varying time steps. Therefore, among different spatial and time domains, we could compare the disaster situations with what was reflected by the same disaster. Additionally, the method overcomes the subjectivity of a comprehensive flood index caused by using an a priori weighting system, which exists in disaster vulnerability estimation of current disasters.

Patterns and biases of climate change threats in the IUCN Red List.

PubMed

Trull, Nicholas; Böhm, Monika; Carr, Jamie

2018-02-01

International Union for Conservation of Nature (IUCN) Red List assessments rely on published data and expert inputs, and biases can be introduced where underlying definitions and concepts are ambiguous. Consideration of climate change threat is no exception, and recently numerous approaches to assessing the threat of climate change to species have been developed. We explored IUCN Red List assessments of amphibians and birds to determine whether species listed as threatened by climate change display distinct patterns in terms of habitat occupied and additional nonclimatic threats faced. We compared IUCN Red List data with a published data set of species' biological and ecological traits believed to infer high vulnerability to climate change and determined whether distributions of climate change-threatened species on the IUCN Red List concur with those of climate change-threatened species identified with the trait-based approach and whether species possessing these traits are more likely to have climate change listed as a threat on the IUCN Red List. Species in some ecosystems (e.g., grassland, shrubland) and subject to particular threats (e.g., invasive species) were more likely to have climate change as a listed threat. Geographical patterns of climate change-threatened amphibians and birds on the IUCN Red List were incongruent with patterns of global species richness and patterns identified using trait-based approaches. Certain traits were linked to increases or decreases in the likelihood of a species being threatened by climate change. Broad temperature tolerance of a species was consistently related to an increased likelihood of climate change threat, indicating counterintuitive relationships in IUCN assessments. To improve the robustness of species assessments of the vulnerability or extinction risk associated with climate change, we suggest IUCN adopt a more cohesive approach whereby specific traits highlighted by our results are considered in Red List assessments. To achieve this and to strengthen the climate change-vulnerability assessments approach, it is necessary to identify and implement logical avenues for further research into traits that make species vulnerable to climate change (including population-level threats). © 2017 Society for Conservation Biology.

No Pet or Their Person Left Behind: Increasing the Disaster Resilience of Vulnerable Groups through Animal Attachment, Activities and Networks.

PubMed

Thompson, Kirrilly; Every, Danielle; Rainbird, Sophia; Cornell, Victoria; Smith, Bradley; Trigg, Joshua

2014-05-07

Increased vulnerability to natural disasters has been associated with particular groups in the community. This includes those who are considered de facto vulnerable (children, older people, those with disabilities etc.) and those who own pets (not to mention pets themselves). The potential for reconfiguring pet ownership from a risk factor to a protective factor for natural disaster survival has been recently proposed. But how might this resilience-building proposition apply to vulnerable members of the community who own pets or other animals? This article addresses this important question by synthesizing information about what makes particular groups vulnerable, the challenges to increasing their resilience and how animals figure in their lives. Despite different vulnerabilities, animals were found to be important to the disaster resilience of seven vulnerable groups in Australia. Animal attachment and animal-related activities and networks are identified as underexplored devices for disseminating or 'piggybacking' disaster-related information and engaging vulnerable people in resilience building behaviors (in addition to including animals in disaster planning initiatives in general). Animals may provide the kind of innovative approach required to overcome the challenges in accessing and engaging vulnerable groups. As the survival of humans and animals are so often intertwined, the benefits of increasing the resilience of vulnerable communities through animal attachment is twofold: human and animal lives can be saved together.

Moderate traumatic brain injury increases the vulnerability to neurotoxicity induced by systemic administration of 6-hydroxydopamine in mice.

PubMed

de Oliveira, Paulo Alexandre; Ben, Juliana; Matheus, Filipe Carvalho; Schwarzbold, Marcelo Liborio; Moreira, Eduardo Luiz Gasnhar; Rial, Daniel; Walz, Roger; Prediger, Rui Daniel

2017-05-15

Moderate traumatic brain injury (TBI) might increase the vulnerability to neuronal neurodegeneration, but the basis of such selective neuronal susceptibility has remained elusive. In keeping with the disruption of the blood-brain barrier (BBB) caused by TBI, changes in BBB permeability following brain injury could facilitate the access of xenobiotics into the brain. To test this hypothesis, here we evaluated whether TBI would increase the susceptibility of nigrostriatal dopaminergic fibers to the systemic administration of 6-hydroxydopamine (6-OHDA), a classic neurotoxin used to trigger a PD-like phenotype in mice, but that in normal conditions is unable to cross the BBB. Adult Swiss mice were submitted to a moderate TBI using a free weight-drop device and, 5h later, they were injected intraperitoneally with a single dose of 6-OHDA (100mg/kg). Afterwards, during a period of 4weeks, the mice were submitted to a battery of behavioral tests, including the neurological severity score (NSS), the open field and the rotarod. Animals from the TBI plus 6-OHDA group displayed significant motor and neurological impairments that were improved by acute l-DOPA administration (25mg/kg, i.p.). Moreover, the observation of the motor deficits correlates with (i) a significant decrease in the tyrosine hydroxylase levels mainly in the rostral striatum and (ii) a significant increase in the levels of striatal glial fibrillary acidic protein (GFAP) levels. On the whole, the present findings demonstrate that a previous moderate TBI event increases the susceptibility to motor, neurological and neurochemical alterations induced by systemic administration of the dopaminergic neurotoxin 6-OHDA in mice. Copyright © 2017 Elsevier B.V. All rights reserved.

Microbial source tracking in highly vulnerable karst drinking water resources.

PubMed

Diston, D; Robbi, R; Baumgartner, A; Felleisen, R

2018-02-01

Water resources situated in areas with underlying karst geology are particularly vulnerable to fecal pollution. In such vulnerable systems, microbial source tracking (MST) methods are useful tools to elucidate the pathways of both animal and human fecal pollution, leading to more accurate water use risk assessments. Here, we describe the application of a MST toolbox using both culture-dependent bacteriophage and molecular-dependent 16S rRNA assays at spring and well sites in the karstic St Imier Valley, Switzerland. Culture-dependent and molecular-dependent marker performance varied significantly, with the 16S rRNA assays displaying greater sensitivity than their phage counterpart; HF183 was the best performing human wastewater-associated marker while Rum2Bac was the best performing ruminant marker. Differences were observed in pollution regimes between the well and spring sampling sites, with the spring water being more degraded than the well site. Our results inform the choice of marker selection for MST studies and highlight differences in microbial water quality between well and spring karst sites.

Child Sexual Abuse Fact Sheet for Parents, Teachers, and Other Caregivers

ERIC Educational Resources Information Center

National Child Traumatic Stress Network, 2009

2009-01-01

Child sexual abuse is any interaction between a child and an adult (or another child) in which the child is used for the sexual stimulation of the perpetrator or an observer. Children of all ages, races, ethnicities, and economic backgrounds are vulnerable to sexual abuse. Children who have been sexually abused may display a range of emotional and…

Vulnerability to Allergic Disorder in Families of Children of Behavioral Inhibition

DTIC Science & Technology

1990-10-07

third years of life. The temperamentally inhibited child consistently displays an initial timidity, shyness, and emotional restraint when exposed to...with the uninhibited, children, reported a higher prevalence of atopic allergies, especially hayfever and eczema . Although the exact mechanisms...As Table 1 reveals, more relatives of inhibited, compared with uninhibited, children reported having hayfever, eczema , and frequent stomach cramps

Dissimilarity in Vulnerability: Self-Reported Symptoms among Children with Experiences of Intimate Partner Violence

ERIC Educational Resources Information Center

Georgsson, Anna; Almqvist, Kjerstin; Broberg, Anders G.

2011-01-01

Children with experiences of intimate partner violence (IPV) are at risk. Not all children, however, display symptoms, and differences connected to gender and age have been demonstrated. In this exploratory study, children's own reports of symptoms were used. The 41 recruited children, between 7 and 19 years old, were entered into a group program…

Intravascular photoacoustic imaging: a new tool for vulnerable plaque identification.

PubMed

Jansen, Krista; van Soest, Gijs; van der Steen, Antonius F W

2014-06-01

The vulnerable atherosclerotic plaque is believed to be at the root of the majority of acute coronary events. Even though the exact origins of plaque vulnerability remain elusive, the thin-cap fibroatheroma, characterized by a lipid-rich necrotic core covered by a thin fibrous cap, is considered to be the most prominent type of vulnerable plaque. No clinically available imaging technique can characterize atherosclerotic lesions to the extent needed to determine plaque vulnerability prognostically. Intravascular photoacoustic imaging (IVPA) has the potential to take a significant step in that direction by imaging both plaque structure and composition. IVPA is a natural extension of intravascular ultrasound that adds tissue type specificity to the images. IVPA utilizes the optical contrast provided by the differences in the absorption spectra of plaque components to image composition. Its capability to image lipids in human coronary atherosclerosis has been shown extensively ex vivo and has recently been translated to an in vivo animal model. Other disease markers that have been successfully targeted are calcium and inflammatory markers, such as macrophages and matrix metalloproteinase; the latter two through application of exogenous contrast agents. By simultaneously displaying plaque morphology and composition, IVPA can provide a powerful prognostic marker for disease progression, and as such has the potential to transform the current practice in percutaneous coronary intervention. Copyright © 2014 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

Bringing indices of species vulnerability to climate change into geographic space: an assessment across the Coronado national forest

Treesearch

Jennifer E. Davison; Sharon Coe; Deborah Finch; Erika Rowland; Megan Friggens; Lisa J. Graumlich

2012-01-01

Indices that rate the vulnerability of species to climate change in a given area are increasingly used to inform conservation and climate change adaptation strategies. These species vulnerability indices (SVI) are not commonly associated with landscape features that may affect local-scale vulnerability. To do so would increase their utility by allowing managers to...

Responses of a vulnerable Hispanic population in New Jersey to Hurricane Sandy: Access to care, medical needs, concerns, and ecological ratings.

PubMed

Burger, Joanna; Gochfeld, Michael; Pittfield, Taryn; Jeitner, Christian

2017-01-01

Recent increases in hurricanes led to a need to evaluate access to medical care, medical needs, and personal and community impact on vulnerable populations, particularly elderly, low income, and minority communities. This investigation examined (1) access to care, (2) interruptions in medical services, (3) personal impact from Hurricane Sandy, and (4) agreement with ecological statements related to storms, flooding, and damages in Hispanic/Latino patients receiving health care at Federally Qualified Health Centers in New Jersey. Only 10% of 335 Hispanic interviewees were US born. Self-identified personal impact was a better indicator of effects from Sandy, health center use, and medical issues, than community impact rating. Respondents who provided a high personal impact rating were more likely to have evacuated, had longer power outage, were more likely to need medical care, displayed more trouble getting to centers, and exhibited more medical interruptions during Sandy. A higher % respondents who evacuated, needed the center, had trouble getting there, and had more "medical need" than those who did not evacuate. The greatest impacts were on respondents who were told to evacuate before the storm, but did not (46% had "medical need"). The respondents had high agreement ratings for "storms are due to climate change," followed by "frequent and stronger storms will come more often," "flooding is due to sea level rise," and "changing climate is due mainly to human activity and not natural causes". These ratings may aid public policymakers and planners in developing resiliency strategies for vulnerable coastal communities.

Development of 10 highly-polymorphic microsatellite markers in the vulnerable Galápagos land iguanas (genus Conolophus).

PubMed

Rosa, Sabrina F P; Monteyne, Daniel; Milinkovitch, Michel C

2009-01-01

The two species of Galápagos land iguanas (Conolophus subcristatus and C. pallidus) are listed as 'vulnerable' species by the International Union for the Conservation of Nature (IUCN Red List; http://www.iucnredlist.org). Here, we report on the isolation and characterization of 10 microsatellite markers using 562 individuals sampled on all Galápagos islands where Conolophus species occur today. We show that these 10 loci are highly polymorphic and display diagnostic alleles for five out of the six island populations. These markers will be useful for Conolophus population genetic analyses as well as for guiding ongoing captive breeding programmes. © 2009 The Authors. Journal compilation © 2009 Blackwell Publishing Ltd.

[Globalization, inequality, and transmission of tropical diseases in the Venezuelan Amazon].

PubMed

Botto-Abella, Carlos; Graterol-Mendoza, Beatriz

2007-01-01

Economic globalization appears to be causing greater inequalities and increased vulnerability to tropical diseases around the world. The Venezuelan Amazon population, especially the rural indigenous population, displays among the worst health indicators in the Americas. High infant mortality rates in remote indigenous populations indicate that such communities have been affected by the globalization of disease, rather than favored by globalization of health. Globalization has also influenced public policies in the country, affecting the efficiency of control programs targeting tropical diseases. A new global pact for the sustainable development of the planet is needed, supported by the globalization of human values and rights. In Venezuela, new policies for the indigenous health sector, more resources, and greater autonomy could help reduce the inequities described here in the Venezuelan Amazon.

No Pet or Their Person Left Behind: Increasing the Disaster Resilience of Vulnerable Groups through Animal Attachment, Activities and Networks

PubMed Central

Thompson, Kirrilly; Every, Danielle; Rainbird, Sophia; Cornell, Victoria; Smith, Bradley; Trigg, Joshua

2014-01-01

Simple Summary The potential for reconfiguring pet ownership from a risk factor to a protective factor for natural disaster survival has been recently proposed. But how might this resilience-building proposition apply to members of the community who are already considered vulnerable? This article addresses this important question by synthesizing information about what makes seven particular groups vulnerable, the challenges to increasing their resilience and how animals figure in their lives. It concludes that animal attachment could provide a novel conduit for accessing, communicating with and motivating vulnerable people to engage in resilience building behaviors that promote survival and facilitate recovery. Abstract Increased vulnerability to natural disasters has been associated with particular groups in the community. This includes those who are considered de facto vulnerable (children, older people, those with disabilities etc.) and those who own pets (not to mention pets themselves). The potential for reconfiguring pet ownership from a risk factor to a protective factor for natural disaster survival has been recently proposed. But how might this resilience-building proposition apply to vulnerable members of the community who own pets or other animals? This article addresses this important question by synthesizing information about what makes particular groups vulnerable, the challenges to increasing their resilience and how animals figure in their lives. Despite different vulnerabilities, animals were found to be important to the disaster resilience of seven vulnerable groups in Australia. Animal attachment and animal-related activities and networks are identified as underexplored devices for disseminating or ‘piggybacking’ disaster-related information and engaging vulnerable people in resilience building behaviors (in addition to including animals in disaster planning initiatives in general). Animals may provide the kind of innovative approach required to overcome the challenges in accessing and engaging vulnerable groups. As the survival of humans and animals are so often intertwined, the benefits of increasing the resilience of vulnerable communities through animal attachment is twofold: human and animal lives can be saved together. PMID:26480038

Chronic restraint stress causes a delayed increase in responding for palatable food cues during forced abstinence via a dopamine D1-like receptor-mediated mechanism.

PubMed

Ball, Kevin T; Best, Olivia; Luo, Jonathan; Miller, Leah R

2017-02-15

Relapse to unhealthy eating habits in dieters is often triggered by stress. Animal models, moreover, have confirmed a causal role for acute stress in relapse. The role of chronic stress in relapse vulnerability, however, has received relatively little attention. Therefore, in the present study, we used an abstinence-based relapse model in rats to test the hypothesis that exposure to chronic stress increases subsequent relapse vulnerability. Rats were trained to press a lever for highly palatable food reinforcers in daily 3-h sessions and then tested for food seeking (i.e., responding for food associated cues) both before and after an acute or chronic restraint stress procedure (3h/day×1day or 10days, respectively) or control procedure (unstressed). The second food seeking test was conducted either 1day or 7days after the last restraint. Because chronic stress causes dopamine D1-like receptor-mediated alterations in prefrontal cortex (a relapse node), we also assessed dopaminergic involvement by administering either SCH-23390 (10.0μg/kg; i.p.), a dopamine D1-like receptor antagonist, or vehicle prior to daily treatments. Results showed that chronically, but not acutely, stressed rats displayed increased food seeking 7days, but not 1day, after the last restraint. Importantly, SCH-23390 combined with chronic stress reversed this effect. These results suggest that drugs targeting D 1 -like receptors during chronic stress may help to prevent future relapse in dieters. Copyright © 2016 Elsevier B.V. All rights reserved.

Chronic restraint stress causes a delayed increase in responding for palatable food cues during forced abstinence via a dopamine D1-like receptor-mediated mechanism

PubMed Central

Ball, Kevin T.; Best, Olivia; Luo, Jonathan; Miller, Leah R.

2016-01-01

Relapse to unhealthy eating habits in dieters is often triggered by stress. Animal models, moreover, have confirmed a causal role for acute stress in relapse. The role of chronic stress in relapse vulnerability, however, has received relatively little attention. Therefore, in the present study, we used an abstinence-based relapse model in rats to test the hypothesis that exposure to chronic stress increases subsequent relapse vulnerability. Rats were trained to press a lever for highly palatable food reinforcers in daily 3-hr sessions and then tested for food seeking (i.e., responding for food associated cues) both before and after an acute or chronic restraint stress procedure (3 h/day × 1 day or 10 days, respectively) or control procedure (unstressed). The second food seeking test was conducted either 1 day or 7 days after the last restraint. Because chronic stress causes dopamine D1-like receptor-mediated alterations in prefrontal cortex (a relapse node), we also assessed dopaminergic involvement by administering either SCH-23390 (10.0 μg/kg; i.p.), a dopamine D1-like receptor antagonist, or vehicle prior to daily treatments. Results showed that chronically, but not acutely, stressed rats displayed increased food seeking 7 days, but not 1 day, after the last restraint. Importantly, SCH-23390 combined with chronic stress reversed this effect. These results suggest that drugs targeting D1-like receptors during chronic stress may help to prevent future relapse in dieters. PMID:27845229

The hydrological vulnerability of western North American boreal tree species based on ground-based observations of tree mortality

NASA Astrophysics Data System (ADS)

Hember, R. A.; Kurz, W. A.; Coops, N. C.

2017-12-01

Several studies indicate that climate change has increased rates of tree mortality, adversely affecting timber supply and carbon storage in western North American boreal forests. Statistical models of tree mortality can play a complimentary role in detecting and diagnosing forest change. Yet, such models struggle to address real-world complexity, including expectations that hydrological vulnerability arises from both drought stress and excess-water stress, and that these effects vary by species, tree size, and competitive status. Here, we describe models that predict annual probability of tree mortality (Pm) of common boreal tree species based on tree height (H), biomass of larger trees (BLT), soil water content (W), reference evapotranspiration (E), and two-way interactions. We show that interactions among H and hydrological variables are consistently significant. Vulnerability to extreme droughts consistently increases as H approaches maximum observed values of each species, while some species additionally show increasing vulnerability at low H. Some species additionally show increasing vulnerability to low W under high BLT, or increasing drought vulnerability under low BLT. These results suggest that vulnerability of trees to increasingly severe droughts depends on the hydraulic efficiency, competitive status, and microclimate of individual trees. Static simulations of Pm across a 1-km grid (i.e., with time-independent inputs of H, BLT, and species composition) indicate complex spatial patterns in the time trends during 1965-2014 and a mean change in Pm of 42 %. Lastly, we discuss how the size-dependence of hydrological vulnerability, in concert with increasingly severe drought events, may shape future responses of stand-level biomass production to continued warming and increasing carbon dioxide concentration in the region.

Study on the Groundwater Vulnerability Assessment in Sanjiang Plain in Northeast China

NASA Astrophysics Data System (ADS)

Tang, Y.; Tang, W. K.; Liu, C.

2012-12-01

The Sanjiang Plain is located in eastern part of China's Heilongjiang Province.It's total area is 109 000 km2, with cultivated land area being 3.6677 million hm2. It is a major national commodity grain base. Rice planting area in Sanjiang Plain has been increasing year by year. Groundwater exploitation is increasing rapidly as a result of rapid increase of paddy field area. It is necessary to research and analyze spatial diversity of groundwater pollution vulnerability for Sanjiang Plain, so as to fulfill the goal of integrated planning, rational utilization of land and water resource, avoiding or minimizing groundwater contamination, and protecting grain security of China. Based on the commonly used DRASTIC method internationally, and according to hydrogeology, land use and other characteristics of Sanjiang Plain, this paper establishes groundwater vulnerability assessment index system. Since the Sanjiang Plain is an area that gives priority to agriculture, and impact of agricultural land and agricultural activity on groundwater vulnerability can not be ignored. Two indicators of agricultural land use rate (L) and population density (P) are increased in the DRASTC index system, the remaining 5 indicators are groundwater depth (D), aquifer net recharge(R), aquifer media type (A), soil type(S), aquifer hydraulic conductivity (C). Taking ArcGis as a calculation analysis platform to assess groundwater vulnerability of the Sanjiang Plain, by using hierarchical analysis method of the fuzzy mathematics method to calculate each index weigh of evaluation vulnerability. This paper applies 6 levels of assessment standard as follows: vulnerability index DI <2 stands for not vulnerable; 2 8 stands for extremely vulnerable. Groundwater vulnerably contaminated area is delineated based on the groundwater vulnerability spatial distribution of Sanjiang Plain. Reasonable land use plan should be made, and strictly groundwater protection measures should be taken to reduce the risk of groundwater contamination.

A synthesized biophysical and social vulnerability assessment for Taiwan

NASA Astrophysics Data System (ADS)

Lee, Yung-Jaan

2017-11-01

Taiwan, located in the Western Pacific, is a country that is one of the most vulnerable to disasters that are associated with the changing climate; it is located within the Ring of Fire, which is the most geologically active region in the world. The environmental and geological conditions in Taiwan are sensitive and vulnerable to such disasters. Owing to increasing urbanization in Taiwan, floods and climate-related disasters have taken an increasing toll on human lives. As global warming accelerates the rising of sea levels and increasing of the frequency of extreme weather events, disasters will continue to affect socioeconomic development and human conditions. Under such circumstances, researchers and policymakers alike must recognize the importance of providing useful knowledge concerning vulnerability, disaster recovery and resilience. Strategies for reducing vulnerability and climate-related disaster risks and for increasing resilience involve preparedness, mitigation and adaptation. In the last two decades, extreme climate events have caused severe flash floods, debris flows, landslides, and other disasters and have had negative effects of many sectors, including agriculture, infrastructure and health. Since climate change is expected to have a continued impact on socio-economic development, this work develops a vulnerability assessment framework that integrates both biophysical and social vulnerability and supports synthesized vulnerability analyses to identify vulnerable areas in Taiwan. Owing to its geographical, geological and climatic features, Taiwan is susceptible to earthquakes, typhoons, droughts and various induced disasters. Therefore, Taiwan has the urgent task of establishing a framework for assessing vulnerability as a planning and policy tool that can be used to identify not only the regions that require special attention but also hotspots in which efforts should be made to reduce vulnerability and the risk of climate-related disaster. To analyze the biophysical vulnerability of Taiwan, hazards on eight maps from Taiwan’s National Science and Technology Center for Disaster Reduction (NCDR) are analyzed. Statistical data from the NCDR on social vulnerability are also adopted. Finally, a GIS overlaying method was used to perform the synthesized vulnerability analysis of biophysical and social vulnerability for municipalities and counties in Taiwan.

Economic development and declining vulnerability to climate-related disasters in China

NASA Astrophysics Data System (ADS)

Wu, Jidong; Han, Guoyi; Zhou, Hongjian; Li, Ning

2018-03-01

Exposure and vulnerability are the main contributing factors of growing impact from climate-related disasters globally. Understanding the spatiotemporal dynamic patterns of vulnerability is important for designing effective disaster risk mitigation and adaptation measures. At national scale, most cross-country studies have suggested that economic vulnerability to disasters decreases as income increases, especially for developing countries. Research covering sub-national climate-related natural disasters is indispensable to obtaining a comprehensive understanding of the effect of regional economic growth on vulnerability reduction. Taking China as a case, this subnational scale study shows that economic development is correlated with the significant reduction in human fatalities but increase in direct economic losses (DELs) from climate-related disasters since 1949. The long-term trend in climate-related disaster vulnerability, reflected by mortality (1978-2015) and DELs (1990-2015) as a share of the total population and Gross Domestic Product, has seen significant decline among all economic regions in China. While notable differences remain among its West, Central and East economic regions, the temporal vulnerability change has been converging. The study further demonstrated that economic development level is correlated with human and economic vulnerability to climate-related disasters, and this vulnerability decreased with the increase of per-capita income. This study suggested that economic development can have nuanced effects on overall human and economic vulnerability to climate-related disasters. We argue that climate change science needs to acknowledge and examine the different pathways of vulnerability effects related to economic development.

Gating Deficits are More Heritable and Correlate with Increased Clinical Severity in Schizophrenia Patients with a Positive versus Negative Family History

PubMed Central

Greenwood, Tiffany A.; Light, Gregory A.; Swerdlow, Neal R.; Calkins, Monica E.; Green, Michael F.; Gur, Raquel E.; Gur, Ruben C.; Lazzeroni, Laura C.; Nuechterlein, Keith H.; Olincy, Ann; Radant, Allen D.; Seidman, Larry J.; Siever, Larry J.; Silverman, Jeremy M.; Stone, William S.; Sugar, Catherine A.; Tsuang, Debby W.; Tsuang, Ming T.; Turetsky, Bruce I.; Freedman, Robert; Braff, David L.

2016-01-01

Objective The Consortium on the Genetics of Schizophrenia Family Study (COGS-1) evaluated 12 primary and other supplementary neurocognitive and neurophysiological endophenotypes in schizophrenia probands and their families. Previous analyses of prepulse inhibition (PPI) and P50 gating measures in this sample revealed heritability estimates that were lower than expected based on earlier family studies. Here we investigated whether gating measures were more heritable in multiply affected families with a positive family history vs. families with only a single affected proband (singleton). Method A total of 296 nuclear families consisting of a schizophrenia proband, at least one unaffected sibling, and both parents underwent a comprehensive endophenotype and clinical characterization. The Family Interview for Genetic Studies was administered to all participants and used to obtain convergent psychiatric symptom information for additional first-degree relatives. Among the families, 97 were multiply affected, and 96 were singletons. Results Both PPI and P50 gating displayed significantly increased heritability in the 97 multiply affected families (47% and 36%, respectively), compared with estimates derived from the entire sample of 296 families (29% and 20%, respectively). However, no evidence for heritability was observed for either measure in the 96 singleton families. Schizophrenia probands derived from the multiply affected families also displayed a significantly increased severity of clinical symptoms compared with those derived from singleton families. Conclusions PPI and P50 gating measures demonstrate substantially increased heritability in schizophrenia families with a higher genetic vulnerability for illness, which provides further support for the commonality of genes underlying both schizophrenia and gating measures. PMID:26441157

Impacts of Urbanization on Precipitation and Storms: Physical Insights and Vulnerabilities

Treesearch

J. M. Shepherd

2013-01-01

On January 19, 2011, an unusual weather event occurred. The National Weather Service Web site (http://www.crh.noaa. gov/news/display_cmsstory.php?wfo¼ddc&storyid¼62980& source¼0) described the event in the following way: “the atmosphere was cold and moist with low clouds and fog preceding the formation of the snow.

Integrating Cybersecurity into the Program Management Organization

DTIC Science & Technology

2015-05-13

penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE 13 MAY 2015 2...Threat to our National Economy DOD Cybersecurity Gaps Could Be Canary in Federal Acquisition Coal Mine Intangible Assets Create Vulnerabilities...operational approach integrates with current or planned CONOPS, BCP, information architecture, programs or initiatives Development  Approach to

Constitutional Law--Irrebuttable Statutory Presemption of Student Non-Residency Held Violative of Due Process Clause of Fourteenth Amendment--Vlandis v. Kline, 93 S. Ct. 2230 (1973)

ERIC Educational Resources Information Center

University of Richmond Law Review, 1974

1974-01-01

In the past the durational residence requirement in colleges and universities has been subject to constitutional challenge under the equal protection clause of the fourteenth amendment. The durational residence requirement in this case displays a further fourteenth amendment vulnerability--the contravention of procedural due process. (Author/PG)

The Development of a Preference for Cocaine over Food Identifies Individual Rats with Addiction-Like Behaviors

PubMed Central

Perry, Adam N.; Westenbroek, Christel; Becker, Jill B.

2013-01-01

Rationale Cocaine dependence is characterized by compulsive drug taking that supercedes other recreational, occupational or social pursuits. We hypothesized that rats vulnerable to addiction could be identified within the larger population based on their preference for cocaine over palatable food rewards. Objectives To validate the choice self-administration paradigm as a preclinical model of addiction, we examined changes in motivation for cocaine and recidivism to drug seeking in cocaine-preferring and pellet-preferring rats. We also examined behavior in males and females to identify sex differences in this “addicted” phenotype. Methods Preferences were identified during self-administration on a fixed-ratio schedule with cocaine-only, pellet-only and choice sessions. Motivation for each reward was probed early and late during self-administration using a progressive-ratio schedule. Reinstatement of cocaine- and pellet-seeking was examined following exposure to their cues and non-contingent delivery of each reward. Results Cocaine preferring rats increased their drug intake at the expense of pellets, displayed increased motivation for cocaine, attenuated motivation for pellets and greater cocaine and cue-induced reinstatement of drug seeking. Females were more likely to develop cocaine preferences and recidivism of cocaine- and pellet-seeking was sexually dimorphic. Conclusions The choice self-administration paradigm is a valid preclinical model of addiction. The unbiased selection criteria also revealed sex-specific vulnerability factors that could be differentiated from generalized sex differences in behavior, which has implications for the neurobiology of addiction and effective treatments in each sex. PMID:24260227

The development of a preference for cocaine over food identifies individual rats with addiction-like behaviors.

PubMed

Perry, Adam N; Westenbroek, Christel; Becker, Jill B

2013-01-01

Cocaine dependence is characterized by compulsive drug taking that supercedes other recreational, occupational or social pursuits. We hypothesized that rats vulnerable to addiction could be identified within the larger population based on their preference for cocaine over palatable food rewards. To validate the choice self-administration paradigm as a preclinical model of addiction, we examined changes in motivation for cocaine and recidivism to drug seeking in cocaine-preferring and pellet-preferring rats. We also examined behavior in males and females to identify sex differences in this "addicted" phenotype. Preferences were identified during self-administration on a fixed-ratio schedule with cocaine-only, pellet-only and choice sessions. Motivation for each reward was probed early and late during self-administration using a progressive-ratio schedule. Reinstatement of cocaine- and pellet-seeking was examined following exposure to their cues and non-contingent delivery of each reward. Cocaine preferring rats increased their drug intake at the expense of pellets, displayed increased motivation for cocaine, attenuated motivation for pellets and greater cocaine and cue-induced reinstatement of drug seeking. Females were more likely to develop cocaine preferences and recidivism of cocaine- and pellet-seeking was sexually dimorphic. The choice self-administration paradigm is a valid preclinical model of addiction. The unbiased selection criteria also revealed sex-specific vulnerability factors that could be differentiated from generalized sex differences in behavior, which has implications for the neurobiology of addiction and effective treatments in each sex.

Mining Bug Databases for Unidentified Software Vulnerabilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dumidu Wijayasekara; Milos Manic; Jason Wright

2012-06-01

Identifying software vulnerabilities is becoming more important as critical and sensitive systems increasingly rely on complex software systems. It has been suggested in previous work that some bugs are only identified as vulnerabilities long after the bug has been made public. These vulnerabilities are known as hidden impact vulnerabilities. This paper discusses the feasibility and necessity to mine common publicly available bug databases for vulnerabilities that are yet to be identified. We present bug database analysis of two well known and frequently used software packages, namely Linux kernel and MySQL. It is shown that for both Linux and MySQL, amore » significant portion of vulnerabilities that were discovered for the time period from January 2006 to April 2011 were hidden impact vulnerabilities. It is also shown that the percentage of hidden impact vulnerabilities has increased in the last two years, for both software packages. We then propose an improved hidden impact vulnerability identification methodology based on text mining bug databases, and conclude by discussing a few potential problems faced by such a classifier.« less

Vulnerability in patients and nurses and the mutual vulnerability in the patient-nurse relationship.

PubMed

Angel, Sanne; Vatne, Solfrid

2017-05-01

To examine the mutual vulnerability of patients and nurses, anticipating that an enhanced understanding of the phenomenon may help reduce vulnerability. Patient vulnerability is a key issue in nursing, aimed at protecting the patient from harm. In the literature, vulnerability is described both from a risk perspective and a subjective perspective. This implies that the objective dimension of patient vulnerability does not necessarily reflect the patient's own perception of being vulnerable. However, external judgment may influence internal perception. Adding to this complexity, attention has also been drawn to the vulnerability of the nurse. A definition deduced from central literature on vulnerability captures the complexity of objective versus subjective vulnerability. Based on the perspective of vulnerability in general, vulnerability in healthcare services shows how dependency may increase patient vulnerability. Further, despite education, training and supportive settings, patients may increase nurse vulnerability. The core of this mutuality is explored in the light of Martin Heidegger's philosophy of being. The patient's need for help from the nurse opens the patient to engage in supportive and/or harmful encounters. Thus, dependency adds to the vulnerability related to health issues. The nurse's vulnerability lies in her engagement in caring for the patient. If failing to provide proper care, the nurse's existence as 'a good nurse' is threatened. This is exacerbated if the patient turns against the nurse. Therefore, the core of vulnerability seems to lie in the fact that the patient and the nurse are both striving to be the persons they want to be, and the persons they have not yet become. Recognition of the mutual vulnerability in the patient-nurse relationship calls for collective acknowledgement of the demanding nature of caring relationships, for support and for a strengthening of professional skills. © 2016 John Wiley & Sons Ltd.

Historical and projected climate (1901–2050) and hydrologic response of karst aquifers, and species vulnerability in south-central Texas and western South Dakota

USGS Publications Warehouse

Stamm, John F.; Poteet, Mary F.; Symstad, Amy J.; Musgrove, MaryLynn; Long, Andrew J.; Mahler, Barbara J.; Norton, Parker A.

2015-12-18

Flora and fauna that rely on springflow from Edwards and Madison aquifer sites were assessed for vulnerability to projected climate change on the basis of the Climate Change Vulnerability Index (CCVI). The CCVI is determined by the exposure of a species to climate, the sensitivity of the species, and the ability of the species to cope with climate change. Sixteen species associated with springs and groundwater were assessed in the Balcones Escarpment region. The Barton Springs salamander (Eurycea sosorum) was scored as highly vulnerable with moderate confidence. Nine species—three salamanders, a fountain darter (Etheostoma fonticola), three insects, and two amphipods—were scored as moderately vulnerable. The remaining six species—four vascular plants, the Barton cavesnail (Stygopyrgus bartonensis), and a cave shrimp—were scored as not vulnerable/presumed stable (not vulnerable and evidence does not support change in abundance or range of the species). Vulnerability of eight species associated with streams that receive springflow from the Madison aquifer in the Black Hills was assessed. Of these, the American dipper (Cinclus mexicanus) and the lesser yellow lady’s slipper (Cypripedium parviflorum) were scored as moderately vulernable with high confidence. The dwarf scouringrush (Equisetum scirpoides) and autumn willow (Salix serissima) were also scored as moderately vulnerable with moderate to low confidence, respectively. Other species were assessed as not vulnerable/presumed stable or not vulnerable/increase likely (not vulnerable and evidence supporting an increase in abundance or range of the species). Lower vulnerability scores for the Black Hills species in comparison to the Balcones Escarpment species reflect lower endemicity, higher projected springflow than in the historical period, and high thermal tolerance of many of the species for the Black Hills. Importantly, climate change vulnerability scores differed substantially for Edwards aquifer species when RRAWFLOW model projections were included, resulting in increased vulnerability scores for 12 of the 16 species.

Nest inundation from sea-level rise threatens sea turtle population viability.

PubMed

Pike, David A; Roznik, Elizabeth A; Bell, Ian

2015-07-01

Contemporary sea-level rise will inundate coastal habitats with seawater more frequently, disrupting the life cycles of terrestrial fauna well before permanent habitat loss occurs. Sea turtles are reliant on low-lying coastal habitats worldwide for nesting, where eggs buried in the sand remain vulnerable to inundation until hatching. We show that saltwater inundation directly lowers the viability of green turtle eggs (Chelonia mydas) collected from the world's largest green turtle nesting rookery at Raine Island, Australia, which is undergoing enigmatic decline. Inundation for 1 or 3 h reduced egg viability by less than 10%, whereas inundation for 6 h reduced viability by approximately 30%. All embryonic developmental stages were vulnerable to mortality from saltwater inundation. Although the hatchlings that emerged from inundated eggs displayed normal physical and behavioural traits, hypoxia during incubation could influence other aspects of the physiology or behaviour of developing embryos, such as learning or spatial orientation. Saltwater inundation can directly lower hatching success, but it does not completely explain the consistently low rates of hatchling production observed on Raine Island. More frequent nest inundation associated with sea-level rise will increase variability in sea turtle hatching success spatially and temporally, due to direct and indirect impacts of saltwater inundation on developing embryos.

Nest inundation from sea-level rise threatens sea turtle population viability

PubMed Central

Pike, David A.; Roznik, Elizabeth A.; Bell, Ian

2015-01-01

Contemporary sea-level rise will inundate coastal habitats with seawater more frequently, disrupting the life cycles of terrestrial fauna well before permanent habitat loss occurs. Sea turtles are reliant on low-lying coastal habitats worldwide for nesting, where eggs buried in the sand remain vulnerable to inundation until hatching. We show that saltwater inundation directly lowers the viability of green turtle eggs (Chelonia mydas) collected from the world's largest green turtle nesting rookery at Raine Island, Australia, which is undergoing enigmatic decline. Inundation for 1 or 3 h reduced egg viability by less than 10%, whereas inundation for 6 h reduced viability by approximately 30%. All embryonic developmental stages were vulnerable to mortality from saltwater inundation. Although the hatchlings that emerged from inundated eggs displayed normal physical and behavioural traits, hypoxia during incubation could influence other aspects of the physiology or behaviour of developing embryos, such as learning or spatial orientation. Saltwater inundation can directly lower hatching success, but it does not completely explain the consistently low rates of hatchling production observed on Raine Island. More frequent nest inundation associated with sea-level rise will increase variability in sea turtle hatching success spatially and temporally, due to direct and indirect impacts of saltwater inundation on developing embryos. PMID:26587269

Variant Brain-Derived Neurotrophic Factor Val66Met Polymorphism Alters Vulnerability to Stress and Response to Antidepressants

PubMed Central

Yu, Hui; Wang, Dong-Dong; Wang, Yue; Liu, Ting; Lee, Francis S.; Chen, Zhe-Yu

2012-01-01

Brain-derived neurotrophic factor (BDNF) plays important roles in cell survival, neural plasticity, learning, and stress regulation. However, whether the recently found human BDNF Val66Met (BDNFMet) polymorphism could alter stress vulnerability remains controversial. More importantly, the molecular and structural mechanisms underlying the interaction between the BDNFMet polymorphism and stress are unclear. We found that heterozygous BDNF+/Met mice displayed hypothalamic-pituitary-adrenal axis hyperreactivity, increased depressive-like and anxiety-like behaviors, and impaired working memory compared with WT mice after 7 d restraint stress. Moreover, BDNF+/Met miceexhibited more prominent changes in BDNF levels and apical dendritic spine density in the prefrontal cortex and amygdala after stress, which correlated with the impaired working memory and elevated anxiety-like behaviors. Finally, the depressive-like behaviors in BDNF+/Met mice could be selectively rescued by acute administration of desipramine but not fluoxetine. These data indicate selective behavioral, molecular, and structural deficits resulting from the interaction between stress and the human genetic BDNFMet polymorphism. Importantly, desipramine but not fluoxetine has antidepressant effects on BDNF+/Met mice, suggesting that specific classes of antidepressant may be a more effective treatment option for depressive symptoms in humans with this genetic variant BDNF. PMID:22442074

The Vulnerabilities of Orphaned Children Participating in Research: A Critical Review and Factors for Consideration for Participation in Biomedical and Behavioral Research

PubMed Central

Thompson, Rachel T.; Meslin, Eric M.; Braitstein, Paula K. A.; Nyandiko, Winstone M.; Ayaya, Samuel O.; Vreeman, Rachel C.

2013-01-01

Orphans are a subpopulation with a unique set of additional vulnerabilities. Increasing focus on children’s rights, pediatric global health, and pediatric research makes it imperative to recognize and address unique vulnerabilities of orphaned children. This paper describes the unique vulnerabilities of the orphaned pediatric population and offers a structured set of factors that require consideration when including orphans in biomedical research. Pediatric orphans are particularly vulnerable due to decreased economic resources, psychosocial instability, increased risk of abuse, and delayed/decreased access to healthcare. These vulnerabilities are significant. By carefully considering each issue in a population in a culturally specific and study-specific manner, researchers can make valuable contributions to the overall health and well-being of this uniquely vulnerable population. PMID:23086048

On underestimation of global vulnerability to tree mortality and forest die-off from hotter drought in the Anthropocene

USGS Publications Warehouse

Allen, Craig D.; Breshears, David D.; McDowell, Nathan G.

2015-01-01

Patterns, mechanisms, projections, and consequences of tree mortality and associated broad-scale forest die-off due to drought accompanied by warmer temperatures—“hotter drought”, an emerging characteristic of the Anthropocene—are the focus of rapidly expanding literature. Despite recent observational, experimental, and modeling studies suggesting increased vulnerability of trees to hotter drought and associated pests and pathogens, substantial debate remains among research, management and policy-making communities regarding future tree mortality risks. We summarize key mortality-relevant findings, differentiating between those implying lesser versus greater levels of vulnerability. Evidence suggesting lesser vulnerability includes forest benefits of elevated [CO2] and increased water-use efficiency; observed and modeled increases in forest growth and canopy greening; widespread increases in woody-plant biomass, density, and extent; compensatory physiological, morphological, and genetic mechanisms; dampening ecological feedbacks; and potential mitigation by forest management. In contrast, recent studies document more rapid mortality under hotter drought due to negative tree physiological responses and accelerated biotic attacks. Additional evidence suggesting greater vulnerability includes rising background mortality rates; projected increases in drought frequency, intensity, and duration; limitations of vegetation models such as inadequately represented mortality processes; warming feedbacks from die-off; and wildfire synergies. Grouping these findings we identify ten contrasting perspectives that shape the vulnerability debate but have not been discussed collectively. We also present a set of global vulnerability drivers that are known with high confidence: (1) droughts eventually occur everywhere; (2) warming produces hotter droughts; (3) atmospheric moisture demand increases nonlinearly with temperature during drought; (4) mortality can occur faster in hotter drought, consistent with fundamental physiology; (5) shorter droughts occur more frequently than longer droughts and can become lethal under warming, increasing the frequency of lethal drought nonlinearly; and (6) mortality happens rapidly relative to growth intervals needed for forest recovery. These high-confidence drivers, in concert with research supporting greater vulnerability perspectives, support an overall viewpoint of greater forest vulnerability globally. We surmise that mortality vulnerability is being discounted in part due to difficulties in predicting threshold responses to extreme climate events. Given the profound ecological and societal implications of underestimating global vulnerability to hotter drought, we highlight urgent challenges for research, management, and policy-making communities.

Impact of hydrogeological factors on groundwater salinization due to ocean-surge inundation

NASA Astrophysics Data System (ADS)

Yang, Jie; Zhang, Huichen; Yu, Xuan; Graf, Thomas; Michael, Holly A.

2018-01-01

Ocean surges cause seawater inundation of coastal inland areas. Subsequently, seawater infiltrates into coastal aquifers and threatens the fresh groundwater resource. The severity of resulting salinization can be affected by hydrogeological factors including aquifer properties and hydrologic conditions, however, little research has been done to assess these effects. To understand the impacts of hydrogeological factors on groundwater salinization, we numerically simulated an ocean-surge inundation event on a two-dimensional conceptual coastal aquifer using a coupled surface-subsurface approach. We varied model permeability (including anisotropy), inland hydraulic gradient, and recharge rate. Three salinization-assessment indicators were developed, based on flushing time, depth of salt penetration, and a combination of the two, weighted flushing time, with which the impact of hydrogeological factors on groundwater vulnerability to salinization were quantitatively assessed. The vulnerability of coastal aquifers increases with increasing isotropic permeability. Low horizontal permeability (kx) and high vertical permeability (kz) lead to high aquifer vulnerability, and high kx and low kz lead to low aquifer vulnerability. Vulnerability decreases with increasing groundwater hydraulic gradient and increasing recharge rate. Additionally, coastal aquifers with a low recharge rate (R ≤ 300 mm yr-1) may be highly vulnerable to ocean-surge inundation. This study shows how the newly introduced indicators can be used to quantitatively assess coastal aquifer vulnerability. The results are important for global vulnerability assessment of coastal aquifers to ocean-surge inundation.

Free and Open Source Software for land degradation vulnerability assessment

NASA Astrophysics Data System (ADS)

Imbrenda, Vito; Calamita, Giuseppe; Coluzzi, Rosa; D'Emilio, Mariagrazia; Lanfredi, Maria Teresa; Perrone, Angela; Ragosta, Maria; Simoniello, Tiziana

2013-04-01

Nowadays the role of FOSS software in scientific research is becoming increasingly important. Besides the important issues of reduced costs for licences, legality and security there are many other reasons that make FOSS software attractive. Firstly, making the code opened is a warranty of quality permitting to thousands of developers around the world to check the code and fix bugs rather than rely on vendors claims. FOSS communities are usually enthusiastic about helping other users for solving problems and expand or customize software (flexibility). Most important for this study, the interoperability allows to combine the user-friendly QGIS with the powerful GRASS-GIS and the richness of statistical methods of R in order to process remote sensing data and to perform geo-statistical analysis in one only environment. This study is focused on the land degradation (i.e. the reduction in the capacity of the land to provide ecosystem goods and services and assure its functions) and in particular on the estimation of the vulnerability levels in order to suggest appropriate policy actions to reduce/halt land degradation impacts, using the above mentioned software. The area investigated is the Basilicata Region (Southern Italy) where large natural areas are mixed with anthropized areas. To identify different levels of vulnerability we adopted the Environmentally Sensitive Areas (ESAs) model, based on the combination of indicators related to soil, climate, vegetation and anthropic stress. Such indicators were estimated by using the following data-sources: - Basilicata Region Geoportal to assess soil vulnerability; - DESERTNET2 project to evaluate potential vegetation vulnerability and climate vulnerability; - NDVI-MODIS satellite time series (2000-2010) with 250m resolution, available as 16-day composite from the NASA LP DAAC to characterize the dynamic component of vegetation; - Agricultural Census data 2010, Corine Land Cover 2006 and morphological information to assess the vulnerability to anthropic factors mainly connected with agricultural and grazing management. To achieve the final ESAs Index depicting the overall vulnerability to degradation of the investigated area we applied the geometric mean to cross normalized indices related to each examined component. In this context QGIS was used to display data and to perform basic GIS calculations, whereas GRASS was used for map-algebra operations and image processing. Finally R was used for computing statistical analysis (Principal Component Analysis) aimed to determine the relative importance of each adopted indicator. Our results show that GRASS, QGIS and R software are suitable to map land degradation vulnerability and identify highly vulnerable areas in which rehabilitation/recovery interventions are urgent. In addition they allow us to put into evidence the most important drivers of degradation thus supplying basic information for the setting up of intervention strategies. Ultimately, Free Open Source Software deliver a fair chance for geoscientific investigations thanks to their high interoperability and flexibility enabling to preserve the accuracy of the data and to reduce processing time. Moreover, the presence of several communities that steadily support users allows for achieving high quality results, making free open source software a valuable and easy alternative to conventional commercial software.

Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer.

PubMed

Kangaspeska, Sara; Hultsch, Susanne; Jaiswal, Alok; Edgren, Henrik; Mpindi, John-Patrick; Eldfors, Samuli; Brück, Oscar; Aittokallio, Tero; Kallioniemi, Olli

2016-07-04

The estrogen receptor (ER) inhibitor tamoxifen reduces breast cancer mortality by 31 % and has served as the standard treatment for ER-positive breast cancers for decades. However, 50 % of advanced ER-positive cancers display de novo resistance to tamoxifen, and acquired resistance evolves in 40 % of patients who initially respond. Mechanisms underlying resistance development remain poorly understood and new therapeutic opportunities are urgently needed. Here, we report the generation and characterization of seven tamoxifen-resistant breast cancer cell lines from four parental strains. Using high throughput drug sensitivity and resistance testing (DSRT) with 279 approved and investigational oncology drugs, exome-sequencing and network analysis, we for the first time, systematically determine the drug response profiles specific to tamoxifen resistance. We discovered emerging vulnerabilities towards specific drugs, such as ERK1/2-, proteasome- and BCL-family inhibitors as the cells became tamoxifen-resistant. Co-resistance to other drugs such as the survivin inhibitor YM155 and the chemotherapeutic agent paclitaxel also occurred. This study indicates that multiple molecular mechanisms dictate endocrine resistance, resulting in unexpected vulnerabilities to initially ineffective drugs, as well as in emerging co-resistances. Thus, combatting drug-resistant tumors will require patient-tailored strategies in order to identify new drug vulnerabilities, and to understand the associated co-resistance patterns.

Ethical practice in internet research involving vulnerable people: lessons from a self-harm discussion forum study (SharpTalk).

PubMed

Sharkey, Siobhan; Jones, Ray; Smithson, Janet; Hewis, Elaine; Emmens, Tobit; Ford, Tamsin; Owens, Christabel

2011-12-01

The internet is widely used for health information and support, often by vulnerable people. Internet-based research raises both familiar and new ethical problems for researchers and ethics committees. While guidelines for internet-based research are available, it is unclear to what extent ethics committees use these. Experience of gaining research ethics approval for a UK study (SharpTalk), involving internet-based discussion groups with young people who self-harm and health professionals is described. During ethical review, unsurprisingly, concerns were raised about the vulnerability of potential participants. These were dominated by the issue of anonymity, which also affected participant safety and consent. These ethical problems are discussed, and our solutions, which included: participant usernames specific to the study, a closed website, private messaging facilities, a direct contact email to researchers, information about forum rules displayed on the website, a 'report' button for participants, links to online support, and a discussion room for forum moderators. This experience with SharpTalk suggests that an approach to ethics, which recognises the relational aspects of research with vulnerable people, is particularly useful for internet-based health research. The solutions presented here can act as guidance for researchers developing proposals and for ethics committees reviewing them.

Lessons from Red Data Books: Plant Vulnerability Increases with Floral Complexity

PubMed Central

Stefanaki, Anastasia; Kantsa, Aphrodite; Tscheulin, Thomas; Charitonidou, Martha; Petanidou, Theodora

2015-01-01

The architectural complexity of flower structures (hereafter referred to as floral complexity) may be linked to pollination by specialized pollinators that can increase the probability of successful seed set. As plant—pollinator systems become fragile, a loss of such specialized pollinators could presumably result in an increased likelihood of pollination failure. This is an issue likely to be particularly evident in plants that are currently rare. Using a novel index describing floral complexity we explored whether this aspect of the structure of flowers could be used to predict vulnerability of plant species to extinction. To do this we defined plant vulnerability using the Red Data Book of Rare and Threatened Plants of Greece, a Mediterranean biodiversity hotspot. We also tested whether other intrinsic (e.g. life form, asexual reproduction) or extrinsic (e.g. habitat, altitude, range-restrictedness) factors could affect plant vulnerability. We found that plants with high floral complexity scores were significantly more likely to be vulnerable to extinction. Among all the floral complexity components only floral symmetry was found to have a significant effect, with radial-flower plants appearing to be less vulnerable. Life form was also a predictor of vulnerability, with woody perennial plants having significantly lower risk of extinction. Among the extrinsic factors, both habitat and maximum range were significantly associated with plant vulnerability (coastal plants and narrow-ranged plants are more likely to face higher risk). Although extrinsic and in particular anthropogenic factors determine plant extinction risk, intrinsic traits can indicate a plant’s proneness to vulnerability. This raises the potential threat of declining global pollinator diversity interacting with floral complexity to increase the vulnerability of individual plant species. There is potential scope for using plant—pollinator specializations to identify plant species particularly at risk and so target conservation efforts towards them. PMID:26390402

Lessons from Red Data Books: Plant Vulnerability Increases with Floral Complexity.

PubMed

Stefanaki, Anastasia; Kantsa, Aphrodite; Tscheulin, Thomas; Charitonidou, Martha; Petanidou, Theodora

2015-01-01

The architectural complexity of flower structures (hereafter referred to as floral complexity) may be linked to pollination by specialized pollinators that can increase the probability of successful seed set. As plant-pollinator systems become fragile, a loss of such specialized pollinators could presumably result in an increased likelihood of pollination failure. This is an issue likely to be particularly evident in plants that are currently rare. Using a novel index describing floral complexity we explored whether this aspect of the structure of flowers could be used to predict vulnerability of plant species to extinction. To do this we defined plant vulnerability using the Red Data Book of Rare and Threatened Plants of Greece, a Mediterranean biodiversity hotspot. We also tested whether other intrinsic (e.g. life form, asexual reproduction) or extrinsic (e.g. habitat, altitude, range-restrictedness) factors could affect plant vulnerability. We found that plants with high floral complexity scores were significantly more likely to be vulnerable to extinction. Among all the floral complexity components only floral symmetry was found to have a significant effect, with radial-flower plants appearing to be less vulnerable. Life form was also a predictor of vulnerability, with woody perennial plants having significantly lower risk of extinction. Among the extrinsic factors, both habitat and maximum range were significantly associated with plant vulnerability (coastal plants and narrow-ranged plants are more likely to face higher risk). Although extrinsic and in particular anthropogenic factors determine plant extinction risk, intrinsic traits can indicate a plant's proneness to vulnerability. This raises the potential threat of declining global pollinator diversity interacting with floral complexity to increase the vulnerability of individual plant species. There is potential scope for using plant-pollinator specializations to identify plant species particularly at risk and so target conservation efforts towards them.

Natural and Human-Induced Variability in Barrier-Island Response to Sea Level Rise

NASA Astrophysics Data System (ADS)

Miselis, Jennifer L.; Lorenzo-Trueba, Jorge

2017-12-01

Storm-driven sediment fluxes onto and behind barrier islands help coastal barrier systems keep pace with sea level rise (SLR). Understanding what controls cross-shore sediment flux magnitudes is critical for making accurate forecasts of barrier response to increased SLR rates. Here, using an existing morphodynamic model for barrier island evolution, observations are used to constrain model parameters and explore potential variability in future barrier behavior. Using modeled drowning outcomes as a proxy for vulnerability to SLR, 0%, 28%, and 100% of the barrier is vulnerable to SLR rates of 4, 7, and 10 mm/yr, respectively. When only overwash fluxes are increased in the model, drowning vulnerability increases for the same rates of SLR, suggesting that future increases in storminess may increase island vulnerability particularly where sediment resources are limited. Developed sites are more vulnerable to SLR, indicating that anthropogenic changes to overwash fluxes and estuary depths could profoundly affect future barrier response to SLR.

Natural and human-induced variability in barrier-island response to sea level rise

USGS Publications Warehouse

Miselis, Jennifer L.; Lorenzo-Trueba, Jorge

2017-01-01

Storm-driven sediment fluxes onto and behind barrier islands help coastal barrier systems keep pace with sea level rise (SLR). Understanding what controls cross-shore sediment flux magnitudes is critical for making accurate forecasts of barrier response to increased SLR rates. Here, using an existing morphodynamic model for barrier island evolution, observations are used to constrain model parameters and explore potential variability in future barrier behavior. Using modeled drowning outcomes as a proxy for vulnerability to SLR, 0%, 28%, and 100% of the barrier is vulnerable to SLR rates of 4, 7, and 10 mm/yr, respectively. When only overwash fluxes are increased in the model, drowning vulnerability increases for the same rates of SLR, suggesting that future increases in storminess may increase island vulnerability particularly where sediment resources are limited. Developed sites are more vulnerable to SLR, indicating that anthropogenic changes to overwash fluxes and estuary depths could profoundly affect future barrier response to SLR.

Summary of vulnerability related technologies based on machine learning

NASA Astrophysics Data System (ADS)

Zhao, Lei; Chen, Zhihao; Jia, Qiong

2018-04-01

As the scale of information system increases by an order of magnitude, the complexity of system software is getting higher. The vulnerability interaction from design, development and deployment to implementation stages greatly increases the risk of the entire information system being attacked successfully. Considering the limitations and lags of the existing mainstream security vulnerability detection techniques, this paper summarizes the development and current status of related technologies based on the machine learning methods applied to deal with massive and irregular data, and handling security vulnerabilities.

Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus.

PubMed

Schmidt, Mathias V; Trümbach, Dietrich; Weber, Peter; Wagner, Klaus; Scharf, Sebastian H; Liebl, Claudia; Datson, Nicole; Namendorf, Christian; Gerlach, Tamara; Kühne, Claudia; Uhr, Manfred; Deussing, Jan M; Wurst, Wolfgang; Binder, Elisabeth B; Holsboer, Florian; Müller, Marianne B

2010-12-15

Increased vulnerability to aversive experiences is one of the main risk factors for stress-related psychiatric disorders as major depression. However, the molecular bases of vulnerability, on the one hand, and stress resilience, on the other hand, are still not understood. Increasing clinical and preclinical evidence suggests a central involvement of the glutamatergic system in the pathogenesis of major depression. Using a mouse paradigm, modeling increased stress vulnerability and depression-like symptoms in a genetically diverse outbred strain, and we tested the hypothesis that differences in AMPA receptor function may be linked to individual variations in stress vulnerability. Vulnerable and resilient animals differed significantly in their dorsal hippocampal AMPA receptor expression and AMPA receptor binding. Treatment with an AMPA receptor potentiator during the stress exposure prevented the lasting effects of chronic social stress exposure on physiological, neuroendocrine, and behavioral parameters. In addition, spatial short-term memory, an AMPA receptor-dependent behavior, was found to be predictive of individual stress vulnerability and response to AMPA potentiator treatment. Finally, we provide evidence that genetic variations in the AMPA receptor subunit GluR1 are linked to the vulnerable phenotype. Therefore, we propose genetic variations in the AMPA receptor system to shape individual stress vulnerability. Those individual differences can be predicted by the assessment of short-term memory, thereby opening up the possibility for a specific treatment by enhancing AMPA receptor function.

Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects.

PubMed

Markus, C Rob; Olivier, Berend; de Haan, Edward H F

2002-06-01

Cognitive performance often declines under chronic stress exposure. The negative effect of chronic stress on performance may be mediated by reduced brain serotonin function. The uptake of the serotonin precursor tryptophan into the brain depends on nutrients that influence the availability of tryptophan by changing the ratio of plasma tryptophan to the sum of the other large neutral amino acids (Trp-LNAA ratio). In addition, a diet-induced increase in tryptophan may increase brain serotonergic activity levels and improve cognitive performance, particularly in high stress-vulnerable subjects. We tested whether alpha-lactalbumin, a whey protein with a high tryptophan content, would increase the plasma Trp-LNAA ratio and improve cognitive performance in high stress- vulnerable subjects. Twenty-three high stress-vulnerable subjects and 29 low stress-vulnerable subjects participated in a double-blind, placebo-controlled, crossover study. All subjects conducted a memory-scanning task after the intake of a diet enriched with either alpha-lactalbumin (alpha-lactalbumin diet) or sodium caseinate (control diet). Blood samples were taken to measure the effect of dietary manipulation on the plasma Trp-LNAA ratio. A significantly greater increase in the plasma Trp-LNAA ratio after consumption of the alpha-lactalbumin diet than after the control diet (P = 0.0001) was observed; memory scanning improved significantly only in the high stress-vulnerable subjects (P = 0.019). Because an increase in the plasma Trp-LNAA ratio is considered to be an indirect indication of increased brain serotonin function, the results suggest that dietary protein rich in alpha-lactalbumin improves cognitive performance in stress-vulnerable subjects via increased brain tryptophan and serotonin activities.

Market mechanisms protect the vulnerable brain.

PubMed

Ramchandran, Kanchna; Nayakankuppam, Dhananjay; Berg, Joyce; Tranel, Daniel; Denburg, Natalie L

2011-07-01

Markets are mechanisms of social exchange, intended to facilitate trading. However, the question remains as to whether markets would help or hurt individuals with decision-makings deficits, as is frequently encountered in the case of cognitive aging. Essential for predicting future gains and losses in monetary and social domains, the striatal nuclei in the brain undergo structural, neurochemical, and functional decline with age. We correlated the efficacy of market mechanisms with dorsal striatal decline in an aging population, by using market based trading in the context of the 2008 U.S. Presidential Elections (primary cycle). Impaired decision-makers displayed higher prediction error (difference between their prediction and actual outcome). Lower in vivo caudate volume was also associated with higher prediction error. Importantly, market-based trading protected older adults with lower caudate volume to a greater extent from their own poorly calibrated predictions. Counterintuitive to the traditional public perception of the market as a fickle, risky proposition where vulnerable traders are most surely to be burned, we suggest that market-based mechanisms protect individuals with brain-based decision-making vulnerabilities. Copyright © 2011 Elsevier Ltd. All rights reserved.

Market mechanisms protect the vulnerable brain

PubMed Central

Ramchandran, Kanchna; Nayakankuppam, Dhananjay; Berg, Joyce; Tranel, Daniel

2011-01-01

Markets are mechanisms of social exchange, intended to facilitate trading. However, the question remains as to whether markets would help or hurt individuals with decision-makings deficits, as is frequently encountered in the case of cognitive aging. Essential for predicting future gains and losses in monetary and social domains, the striatal nuclei in the brain undergo structural, neurochemical, and functional decline with age. We correlated the efficacy of market mechanisms with dorsal striatal decline in an aging population, by using market based trading in the context of the 2008 U.S Presidential Elections (primary cycle). Impaired decision-makers displayed higher prediction error (difference between their prediction and actual outcome). Lower in vivo caudate volume was also associated with higher prediction error. Importantly, market-based trading protected older adults with lower caudate volume to a greater extent from their own poorly calibrated predictions. Counterintuitive to the traditional public perception of the market as a fickle, risky proposition where vulnerable traders are most surely to be burned, we suggest that market-based mechanisms protect individuals with brain-based decision-making vulnerabilities. PMID:21600226

Exploration De La Résilience éducationnelle Chez Des Enseignants

NASA Astrophysics Data System (ADS)

Théorêt, Manon; Garon, Roseline; Hrimech, Mohamed; Carpentier, Anylène

2006-12-01

AN EXPLORATION OF THE EDUCATIONAL RESILIENCE OF TEACHING STAFF - This study focuses on the degree of resilience displayed by teaching staff with the aim of promoting their professional development and preventing job-related exhaustion. Seven underprivileged schools in Montreal were selected, and 24 teaching staff with contrasting personal profiles were interviewed on the subject of their work. The Alceste software was used to analyse the conversations, which revolved around techniques applied when dealing with critical incidents. The main analysis identified five different discourses among the respondents. Three of these were associated with the more resilient of the teachers and two were associated with the more vulnerable ones. Resilient teaching staff characteristically discussed dealing with aggressive behaviour, the teaching-learning relationship and the subject of social relationships, whereas vulnerable teaching staff focused on work beyond the classroom, people in positions of higher authority and the community. The authors note that teachers who are just embarking on their careers appear more vulnerable than more experienced teaching staff, which suggests that more resources should be provided to support teachers in their profession.

Current & future vulnerability of sarasota county Florida to hurricane storm surge & sea level rise

USGS Publications Warehouse

Frazier, T.; Wood, N.; Yarnal, B.

2008-01-01

Coastal communities in portions of the United States are vulnerable to storm-surge inundation from hurricanes and this vulnerability will likely increase, given predicted rises in sea level from climate change and growing coastal development. In this paper, we provide an overview of research to determine current and future societal vulnerability to hurricane storm-surge inundation and to help public officials and planners integrate these scenarios into their long-range land use plans. Our case study is Sarasota County, Florida, where planners face the challenge of balancing increasing population growth and development with the desire to lower vulnerability to storm surge. Initial results indicate that a large proportion of Sarasota County's residential and employee populations are in areas prone to storm-surge inundation from a Category 5 hurricane. This hazard zone increases when accounting for potential sea-level-rise scenarios, thereby putting additional populations at risk. Subsequent project phases involve the development of future land use and vulnerability scenarios in collaboration with local officials. Copyright ASCE 2008.

What Does Vulnerability Mean?

ERIC Educational Resources Information Center

Parley, Fiona F

2011-01-01

Protection of those deemed vulnerable has received increasing attention since 2000. This article reports on care staff views of vulnerability using original data from a research study (Parley. "Vulnerability and abuse: an exploration of views of care staff working with people who have learning disabilities," PhD Thesis, 2007) in which care staff…

Growth and stable isotope signals associated with drought-related mortality in saplings of two coexisting pine species.

PubMed

Herrero, Asier; Castro, Jorge; Zamora, Regino; Delgado-Huertas, Antonio; Querejeta, José I

2013-12-01

Drought-induced events of massive tree mortality appear to be increasing worldwide. Species-specific vulnerability to drought mortality may alter patterns of species diversity and affect future forest composition. We have explored the consequences of the extreme drought of 2005, which caused high sapling mortality (approx. 50 %) among 10-year-old saplings of two coexisting pine species in the Mediterranean mountains of Sierra Nevada (Spain): boreo-alpine Pinus sylvestris and Mediterranean P. nigra. Sapling height growth, leaf δ(13)C and δ(18)O, and foliar nitrogen concentration in the four most recent leaf cohorts were measured in dead and surviving saplings. The foliar isotopic composition of dead saplings (which reflects time-integrated leaf gas-exchange until mortality) displayed sharp increases in both δ(13)C and δ(18)O during the extreme drought of 2005, suggesting an important role of stomatal conductance (g(s)) reduction and diffusional limitations to photosynthesis in mortality. While P. nigra showed decreased growth in 2005 compared to the previous wetter year, P. sylvestris maintained similar growth levels in both years. Decreased growth, coupled with a sharper increase in foliar δ(18)O during extreme drought in dead saplings, indicate a more conservative water use strategy for P. nigra. The different physiological behavior of the two pine species in response to drought (further supported by data from surviving saplings) may have influenced 2005 mortality rates, which contributed to 2.4-fold greater survival for P. nigra over the lifespan of the saplings. This species-specific vulnerability to extreme drought could lead to changes in dominance and distribution of pine species in Mediterranean mountain forests.

Vulnerability to cavitation, hydraulic efficiency, growth and survival in an insular pine (Pinus canariensis).

PubMed

López, Rosana; López de Heredia, Unai; Collada, Carmen; Cano, Francisco Javier; Emerson, Brent C; Cochard, Hervé; Gil, Luis

2013-06-01

It is widely accepted that hydraulic failure due to xylem embolism is a key factor contributing to drought-induced mortality in trees. In the present study, an attempt is made to disentangle phenotypic plasticity from genetic variation in hydraulic traits across the entire distribution area of a tree species to detect adaptation to local environments. A series of traits related to hydraulics (vulnerability to cavitation and hydraulic conductivity in branches), growth performance and leaf mass per area were assessed in eight Pinus canariensis populations growing in two common gardens under contrasting environments. In addition, the neutral genetic variability (FST) and the genetic differentiation of phenotypic variation (QST) were compared in order to identify the evolutionary forces acting on these traits. The variability for hydraulic traits was largely due to phenotypic plasticity. Nevertheless, the vulnerability to cavitation displayed a significant genetic variability (approx. 5 % of the explained variation), and a significant genetic × environment interaction (between 5 and 19 % of the explained variation). The strong correlation between vulnerability to cavitation and survival in the xeric common garden (r = -0·81; P < 0·05) suggests a role for the former in the adaptation to xeric environments. Populations from drier sites and higher temperature seasonality were less vulnerable to cavitation than those growing at mesic sites. No trade-off between xylem safety and efficiency was detected. QST of parameters of the vulnerability curve (0·365 for P50 and the slope of the vulnerability curve and 0·452 for P88) differed substantially from FST (0·091), indicating divergent selection. In contrast, genetic drift alone was found to be sufficient to explain patterns of differentiation for xylem efficiency and growth. The ability of P. canariensis to inhabit a wide range of ecosystems seemed to be associated with high phenotypic plasticity and some degree of local adaptations of xylem and leaf traits. Resistance to cavitation conferred adaptive potential for this species to adapt successfully to xeric conditions.

The hack attack - Increasing computer system awareness of vulnerability threats

NASA Technical Reports Server (NTRS)

Quann, John; Belford, Peter

1987-01-01

The paper discusses the issue of electronic vulnerability of computer based systems supporting NASA Goddard Space Flight Center (GSFC) by unauthorized users. To test the security of the system and increase security awareness, NYMA, Inc. employed computer 'hackers' to attempt to infiltrate the system(s) under controlled conditions. Penetration procedures, methods, and descriptions are detailed in the paper. The procedure increased the security consciousness of GSFC management to the electronic vulnerability of the system(s).

[Socioeconomic vulnerability and obesity in Chilean schoolchildren attending first grade: comparison between 2009 and 2013].

PubMed

Herrera, Juan Carlos; Lira, Mariana; Kain, Juliana

2017-12-01

Although obesity is related to socioeconomic level, studies are inconclusive. To determine obesity risk according to socioeconomic vulnerability among Chilean children (1st grade) in 2009 and 2013 and assess its change during that period, by sex and geographical area. Cross-sectional study (N = 175,462 in 2009) and (N = 189,055 in 2013) which included: weight, height, rural / urban, gender and vulnerability obtained from JUNAEB's survey. BMI Z, % obesity and 3 categories of vulnerability (very vulnerable, moderate, non-vulnerable) were determined. For the descriptive analyses, we used t tests and for predictor variables (2 categories of vulnerability) and outcome (obesity) by sex and area, we used %2. Logistic regression models determined OR to develop obesity by. % obesity was 19.6% and 24.1% in 2009 and 2013, higher in boys. In urban and rural areas respectively, OR to develop obesity were: 0.85 (0.82-0.88) and 0.70 (0.64-0.75) in the most vulnerable students and 0.94 (0.91-0.97) and 0.81 (0.74-0.88) in those with moderate vulnerability in 2009 and 0.96 (0.93-0.98) and 0.89 (0.82-0.96) in the most vulnerable students and 0.99 (0.96-1.02) and 0.94 (0.86-1.02) in students with moderate vulnerability in 2013. The highest increase in obesity was observed among the most vulnerable group from rural areas (16, 6 to 24.3%). vulnerability. The non-vulnerable group had the highest % obesity. Although the most vulnerable students in rural areas had the lowest obesity risk in both years, the highest increase in obesity during the period, occurred in that group.

Analgesia for early-life pain prevents deficits in adult anxiety and stress in rats.

PubMed

Victoria, Nicole C; Karom, Mary C; Murphy, Anne Z

2015-01-01

Previous studies in rats have established that inflammatory pain experienced on the day of birth (P0) decreases sensitivity to acute noxious, anxiety- and stress-provoking stimuli. However, to date, the impact of early-life pain on adult responses to chronic stress is not known. Further, the ability of morphine, administered at the time of injury, to mitigate changes in adult behavioral and hormonal responses to acute or chronic stressors has not been examined. P0 male and female Sprague-Dawley rat pups were given an intraplantar injection of 1% carrageenan or handled in an identical manner in the presence or absence of morphine. As adults, rats that experienced early-life pain displayed decreased sensitivity to acute stressors, as indicated by increased time in the inner area of the Open Field, and increased latency to immobility and decreased time immobile in the Forced Swim Test (FST). An accelerated return of corticosterone to baseline was also observed. Morphine administration at the time of injury completely reversed this 'hyporesponsive' phenotype. By contrast, following 7 days of chronic variable stress, injured animals displayed a 'hyperresponsive' phenotype in that they initiated immobility and spent significantly more time immobile in the FST than controls. Responses to chronic stress were also rescued in animals that received morphine at the time of injury. These data suggest that analgesia for early-life pain prevents adult hyposensitivity to acute anxiety- and stress-provoking stimuli and increased vulnerability to chronic stress, and have important clinical implications for the management of pain in infants. © 2014 S. Karger AG, Basel.

An atmospheric vulnerability assessment framework for environment management and protection based on CAMx.

PubMed

Zhang, Yang; Shen, Jing; Li, Yu

2018-02-01

This paper presents an atmospheric vulnerability assessment framework based on CAMx that should be helpful to assess potential impacts of changes in human, atmospheric environment, and social economic elements of atmospheric vulnerability. It is also a useful and effective tool that can provide policy-guidance for environmental protection and management to reduce the atmospheric vulnerability. The developed framework was applied to evaluate the atmospheric environment vulnerability of 13 cities in the Beijing-Tianjin-Hebei (BTH) region for verification. The results indicated that regional disparity of the atmospheric vulnerability existed in the study site. More specifically, the central and southern regions show more atmospheric environment vulnerability than the northern regions. The impact factors of atmospheric environment vulnerability in the BTH region mainly derived from increasing population press, frequently unfavorable meteorological conditions, extensive economic growth of secondary industry, increased environmental pollution, and accelerating population aging. The framework shown in this paper is an interpretative and heuristic tool for a better understanding of atmospheric vulnerability. This framework can also be replicated at different spatial and temporal scales using context-specific datasets to straightly support environmental managers with decision-making. Copyright © 2017 Elsevier Ltd. All rights reserved.

Forest climate change Vulnerability and Adaptation Assessment in Himalayas

NASA Astrophysics Data System (ADS)

Chitale, V. S.; Shrestha, H. L.; Agarwal, N. K.; Choudhurya, D.; Gilani, H.; Dhonju, H. K.; Murthy, M. S. R.

2014-11-01

Forests offer an important basis for creating and safeguarding more climate-resilient communities over Hindu Kush Himalayan region. The forest ecosystem vulnerability assessment to climate change and developing knowledge base to identify and support relevant adaptation strategies is realized as an urgent need. The multi scale adaptation strategies portray increasing complexity with the increasing levels in terms of data requirements, vulnerability understanding and decision making to choose a particular adaptation strategy. We present here how such complexities could be addressed and adaptation decisions could be either directly supported by open source remote sensing based forestry products or geospatial analysis and modelled products. The forest vulnerability assessment under climate change scenario coupled with increasing forest social dependence was studied using IPCC Landscape scale Vulnerability framework in Chitwan-Annapurna Landscape (CHAL) situated in Nepal. Around twenty layers of geospatial information on climate, forest biophysical and forest social dependence data was used to assess forest vulnerability and associated adaptation needs using self-learning decision tree based approaches. The increase in forest fires, evapotranspiration and reduction in productivity over changing climate scenario was observed. The adaptation measures on enhancing productivity, improving resilience, reducing or avoiding pressure with spatial specificity are identified to support suitable decision making. The study provides spatial analytical framework to evaluate multitude of parameters to understand vulnerabilities and assess scope for alternative adaptation strategies with spatial explicitness.

RSLR-induced increase of vulnerability to storms along the Catalan coast (NW Mediterranean)

NASA Astrophysics Data System (ADS)

Bosom, Eva; Jiménez, José A.; Nicholls, Robert J.

2014-05-01

Climate-related hazards are affecting coasts worldwide and they are likely to increase during the next decades (Nicholls et al., 2007). If we also consider that values at exposure are also increasing, coastal areas will very likely be exposed to increasing risks. Due to this, to properly develop sustainable coastal risk management plans it is necessary to consider climate-change induced effects as an additional forcing. Within this context, vulnerability assessment is a useful tool to help managers to make decisions in resource allocation and development of DRR plans. Vulnerability can be simply defined as the potential of a coastal system to be harmed by a given hazard. The negative contribution (susceptibility) is characterized through the magnitude of main induced processes (erosion and inundation) whereas the positive one (resilience) is parameterized in function of beach geomorphology. With respect to extreme events, Bosom and Jiménez (2011) presented a framework to assess coastal vulnerability to storms at regional scale adopting a probabilistic approach. In this work, this framework is enlarged by including the potential effects of RSLR on the vulnerability assessment. Thus, RSLR-driven processes (erosion and inundation) are accounted through their induced modifications on beach morphology that can affect the beach capacity of response or, in other words, its adaptation capacity. The inclusion of this effect in the vulnerability framework significantly changes coastal vulnerability values to storms at any probability of occurrence without the need of considering any change in storminess. The magnitude of the vulnerability increase depends on the considered RSLR scenario and the coastal geomorphology. This integrated framework has been applied to 219 km of the Catalan coast (NW Mediterranean) considering different RSLR scenarios and time projections. Preliminary results obtained for a Tr = 50-y and the medium RSLR scenario (3.8 mm/y + subsidence) indicate a significant increase in coastal stretches with a high and very high vulnerability to storms. Thus, regarding erosion, these vulnerable stretches increase from 28 % of the coast under current conditions to 39 % and 49 % in 25-y and 50-y projections. With respect to inundation and, considering the dynamic response of the coast, the increase is smaller, from 31 % to 35 % and 40% respectively. References Nicholls RJ et al. 2007. Coastal systems and low-lying areas. Climate Change 2007: Impacts, Adaptation and Vulnerability. Contribution of WG II to 4th Assessment Report of IPCC, 315-356. Bosom E, Jiménez JA. 2011. Probabilistic coastal vulnerability assessment to storms at regional scale - application to Catalan beaches (NW Mediterranean). NHESS11:475-484. Acknowledgements This work has been done in the framework of the PaiRisC-M (CTM2011-29808) and RISC-KIT EU FP7 research project (603458). First author was supported by a Ph D Grant from the Spanish Ministry of Education.

Embryo-fetal development studies with the dietary supplement vinpocetine in the rat and rabbit.

PubMed

Catlin, Natasha; Waidyanatha, Suramya; Mylchreest, Eve; Miller-Pinsler, Lutfiya; Cunny, Helen; Foster, Paul; Sutherland, Vicki; McIntyre, Barry

2018-06-01

Dietary supplement and natural product use is increasing within the United States, resulting in growing concern for exposure in vulnerable populations, including young adults and women of child-bearing potential. Vinpocetine is a semisynthetic derivative of the Vinca minor extract, vincamine. Human exposure to vinpocetine occurs through its use as a dietary supplement for its purported nootropic and neuroprotective effects. To investigate the effects of vinpocetine on embryo-fetal development, groups of 25 pregnant Sprague-Dawley rats and 8 pregnant New Zealand White rabbits were orally administered 0, 5, 20, or 60 mg vinpocetine/kg and 0, 25, 75, 150, or 300 mg/kg daily from gestational day (GD) 6-20 and GD 7-28, respectively. Pregnant rats dosed with vinpocetine demonstrated dose-dependent increases in postimplantation loss, higher frequency of early and total resorptions, lower fetal body weights, and fewer live fetuses following administration of 60 mg/kg, in the absence of maternal toxicity. Additionally, the rat fetuses displayed dose-dependent increases in the incidences of ventricular septum defects and full supernumerary thoracolumbar ribs. Similarly, albeit at higher doses than the rats, pregnant rabbits administered vinpocetine displayed an increase in postimplantation loss and fewer live fetuses (300 mg/kg), in addition to significantly lower fetal body weights (≥75 mg/kg). In conclusion, vinpocetine exposure resulted in similar effects on embryo-fetal development in the rat and rabbit. The species differences in sensitivity and magnitude of response is likely attributable to a species difference in metabolism. Taken together, these data suggest a potential hazard for pregnant women who may be taking vinpocetine. © 2018 Wiley Periodicals, Inc.

Combining landscape variables and species traits can improve the utility of climate change vulnerability assessments

USGS Publications Warehouse

Nadeau, Christopher P.; Fuller, Angela K.

2016-01-01

Conservation organizations worldwide are investing in climate change vulnerability assessments. Most vulnerability assessment methods focus on either landscape features or species traits that can affect a species vulnerability to climate change. However, landscape features and species traits likely interact to affect vulnerability. We compare a landscape-based assessment, a trait-based assessment, and an assessment that combines landscape variables and species traits for 113 species of birds, herpetofauna, and mammals in the northeastern United States. Our aim is to better understand which species traits and landscape variables have the largest influence on assessment results and which types of vulnerability assessments are most useful for different objectives. Species traits were most important for determining which species will be most vulnerable to climate change. The sensitivity of species to dispersal barriers and the species average natal dispersal distance were the most important traits. Landscape features were most important for determining where species will be most vulnerable because species were most vulnerable in areas where multiple landscape features combined to increase vulnerability, regardless of species traits. The interaction between landscape variables and species traits was important when determining how to reduce climate change vulnerability. For example, an assessment that combines information on landscape connectivity, climate change velocity, and natal dispersal distance suggests that increasing landscape connectivity may not reduce the vulnerability of many species. Assessments that include landscape features and species traits will likely be most useful in guiding conservation under climate change.

The implementation of fail-operative functions in integrated digital avionics systems

NASA Technical Reports Server (NTRS)

Osoer, S. S.

1976-01-01

System architectures which incorporate fail operative flight guidance functions within a total integrated avionics complex are described. It is shown that the mixture of flight critical and nonflight critical functions within a common computer complex is an efficient solution to the integration of navigation, guidance, flight control, display, and flight management. Interfacing subsystems retain autonomous capability to avoid vulnerability to total avionics system shutdown as a result of only a few failures.

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

PubMed Central

Yu, Channing; Mannan, Aristotle M.; Yvone, Griselda Metta; Ross, Kenneth N.; Zhang, Yan-Ling; Marton, Melissa A.; Taylor, Bradley R.; Crenshaw, Andrew; Gould, Joshua Z.; Tamayo, Pablo; Weir, Barbara A.; Tsherniak, Aviad; Wong, Bang; Garraway, Levi A.; Shamji, Alykhan F.; Palmer, Michelle A.; Foley, Michael A.; Winckler, Wendy; Schreiber, Stuart L.; Kung, Andrew L.; Golub, Todd R.

2016-01-01

Hundreds of genetically characterized cell lines are available for the discovery of genotype-specific cancer vulnerabilities. However, screening large numbers of compounds against large numbers of cell lines is currently impractical, and such experiments are often difficult to control1-4. Here, we report a method called PRISM that allows pooled screening of mixtures of cancer cell lines by labeling each cell line with 24-nucleotide barcodes. PRISM displayed the expected patterns of cell killing seen in conventional (unpooled) assays. In a screen of 102 cell lines across 8,400 compounds, PRISM led to the identification of BRD-7880 as a potent and highly specific inhibitor of aurora kinases B and C. Cell line pools also efficiently formed tumors as xenografts, and PRISM recapitulated the expected pattern of erlotinib sensitivity in vivo. PMID:26928769

Me, us, or them: who is more conformist? Perception of conformity and political orientation.

PubMed

Cavazza, Nicoletta; Mucchi-Faina, Angelica

2008-06-01

Research has shown that people perceive others as more vulnerable than themselves to media communication, and their political out-group as more vulnerable than their political in-group. In the present study, the authors predicted that the same two biases would appear with respect to another kind of influence--conformity--but that participants' judgments would display a different pattern according to their political orientations. Right-wing and left-wing university students were asked to evaluate conformity and to estimate how conformist they, their political in-group, their political out-group, and other groups are. As hypothesized, right-wingers expressed more ambivalence toward conformity and viewed it less negatively than did left-wingers. Political orientation had no impact on the discrepancy between self and others, but it did moderate the in-group-out-group discrepancy.

Factor weighting in DRASTIC modelling for assessing the groundwater vulnerability in Salatiga groundwater basin, Central Java Province, Indonesia

NASA Astrophysics Data System (ADS)

Kesuma, D. A.; Purwanto, P.; Putranto, T. T.; Rahmani, T. P. D.

2017-06-01

The increase in human population as well as area development in Salatiga Groundwater Basin, Central Java Province, will increase the potency of groundwater contamination in that area. Groundwater quality, especially the shallow groundwater, is very vulnerable to the contamination from industrial waste, fertilizer/agricultural waste, and domestic waste. The first step in the conservation of groundwater quality is by conducting the mapping of the groundwater vulnerability zonation against the contamination. The result of this research was groundwater vulnerability map which showed the areas vulnerable to the groundwater contamination. In this study, groundwater vulnerability map was assessed based on the DRASTIC Method and was processed spatially using Geographic Information System. The DRASTIC method is used to assess the level of groundwater vulnerability based on weighting on seven parameters, which are: depth to the water table (D), recharge (R), aquifer material (A), soil media (S), topography (T), impact of vadose zone (I), and hydraulic conductivity (C). The higher the DRASTIC Index will result in the higher vulnerability level of groundwater contamination in that area. The DRASTIC Indexes in the researched area were 85 - 100 (low vulnerability level), 101 -120 (low to moderate vulnerability level), 121 - 140 (moderate vulnerability level), 141 - 150, (moderate to high vulnerability level), and 151 - 159 (high vulnerability level). The output of this study can be used by local authority as a tool for consideration to arrange the policy for sustainable area development, especially the development in an area affecting the quality of Salatiga Groundwater Basin.

High locomotor reactivity to novelty is associated with an increased propensity to choose saccharin over cocaine: new insights into the vulnerability to addiction.

PubMed

Vanhille, Nathalie; Belin-Rauscent, Aude; Mar, Adam C; Ducret, Eric; Belin, David

2015-02-01

Drug addiction is associated with a relative devaluation of natural or socially-valued reinforcers that are unable to divert addicts from seeking and consuming the drug. Before protracted drug exposure, most rats prefer natural rewards, such as saccharin, over cocaine. However, a subpopulation of animals prefer cocaine over natural rewards and are thought to be vulnerable to addiction. Specific behavioral traits have been associated with different dimensions of drug addiction. For example, anxiety predicts loss of control over drug intake whereas sensation seeking and sign-tracking are markers of a greater sensitivity to the rewarding properties of the drug. However, how these behavioral traits predict the disinterest for natural reinforcers remains unknown. In a population of rats, we identified sensation seekers (HR) on the basis of elevated novelty-induced locomotor reactivity, high anxious rats (HA) based on the propensity to avoid open arms in an elevated-plus maze and sign-trackers (ST) that are prone to approach, and interaction with, reward-associated stimuli. Rats were then tested on their preference for saccharin over cocaine in a discrete-trial choice procedure. We show that HR rats display a greater preference for saccharin over cocaine compared with ST and HA whereas the motivation for the drug was comparable between the three groups. The present data suggest that high locomotor reactivity to novelty, or sensation seeking, by predisposing to an increased choice toward non-drug rewards at early stages of drug use history, may prevent the establishment of chronic cocaine use.

Got worms? Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection.

PubMed

Williamson, Lauren L; McKenney, Erin A; Holzknecht, Zoie E; Belliveau, Christine; Rawls, John F; Poulton, Susan; Parker, William; Bilbo, Staci D

2016-01-01

The incidence of autoimmune and inflammatory diseases has risen dramatically in post-industrial societies. "Biome depletion" - loss of commensal microbial and multicellular organisms such as helminths (intestinal worms) that profoundly modulate the immune system - may contribute to these increases. Hyperimmune-associated disorders also affect the brain, especially neurodevelopment, and increasing evidence links early-life infection to cognitive and neurodevelopmental disorders. We have demonstrated previously that rats infected with bacteria as newborns display life-long vulnerabilities to cognitive dysfunction, a vulnerability that is specifically linked to long-term hypersensitivity of microglial cell function, the resident immune cells of the brain. Here, we demonstrate that helminth colonization of pregnant dams attenuated the exaggerated brain cytokine response of their offspring to bacterial infection, and that combined with post-weaning colonization of offspring with helminths (consistent with their mothers treatment) completely prevented enduring microglial sensitization and cognitive dysfunction in adulthood. Importantly, helminths had no overt impact on adaptive immune cell subsets, whereas exaggerated innate inflammatory responses in splenic macrophages were prevented. Finally, helminths altered the effect of neonatal infection on the gut microbiome; neonatal infection with Escherichia coli caused a shift from genera within the Actinobacteria and Tenericutes phyla to genera in the Bacteroidetes phylum in rats not colonized with helminths, but helminths attenuated this effect. In sum, these data point toward an inter-relatedness of various components of the biome, and suggest potential mechanisms by which this helminth might exert therapeutic benefits in the treatment of neuroinflammatory and cognitive disorders. Copyright © 2015 Elsevier Inc. All rights reserved.

Vulnerabilities to Health Disparities and Statin Use in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study.

PubMed

Schroff, Praful; Gamboa, Christopher M; Durant, Raegan W; Oikeh, Asikhame; Richman, Joshua S; Safford, Monika M

2017-08-28

Statins may be underutilized in certain vulnerable populations, but the effect of cumulative vulnerabilities within 1 individual is not well described. We sought to determine the likelihood of receiving statins with an increasing number of vulnerabilities in an individual, after controlling for factors known to influence health services utilization. We identified 18 216 participants from the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study who had a statin indication or who were taking statins, as verified by pill bottle review. Statin use was assessed with respect to 5 major vulnerability domains alone and in combination: older age, black race, female sex, high area-level poverty, and lack of health insurance. The study included 5286 white men, 4180 black men, 2791 white women, and 4194 black women; 5.6% of the sample had no vulnerabilities, 20.6% had 1 vulnerability, 29.2% had 2 vulnerabilities, 27.3% had 3 vulnerabilities, and 17.3% had 4 or 5 vulnerabilities. All race-sex groups were less likely than white men to use statins; prevalence of use was 0.80 in black women with reference to white men ( P <0.0001). In both unadjusted and adjusted models, as the number of vulnerabilities increased, statin use steadily decreased. After adjusting for factors that influence health services utilization, compared with those without any vulnerabilities, statin use prevalence was 0.91, 0.83, 0.74 and 0.68 ( P <0.0001) in those with 1, 2, 3, and 4 or 5 vulnerabilities, respectively. Participants with more simultaneously occurring vulnerabilities experienced the greatest disparities in statin use. Black women and those without health insurance were at particularly high risk of underutilization. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

Assessing societal vulnerability of U.S. Pacific Northwest communities to storm-induced coastal change

USGS Publications Warehouse

Baron, Heather M.; Wood, Nathan J.; Ruggerio, Peter; Allan, Jonathan; Corcoran, Patrick

2010-01-01

Progressive increases in storm intensities and extreme wave heights have been documented along the U.S. West Coast. Paired with global sea level rise and the potential for an increase in El Niño occurrences, these trends have substantial implications for the vulnerability of coastal communities to natural coastal hazards. Community vulnerability to hazards is characterized by the exposure, sensitivity, and adaptive capacity of human-environmental systems that influence potential impacts. To demonstrate how societal vulnerability to coastal hazards varies with both physical and social factors, we compared community exposure and sensitivity to storm-induced coastal change scenarios in Tillamook (Oregon) and Pacific (Washington) Counties. While both are backed by low-lying coastal dunes, communities in these two counties have experienced different shoreline change histories and have chosen to use the adjacent land in different ways. Therefore, community vulnerability varies significantly between the two counties. Identifying the reasons for this variability can help land-use managers make decisions to increase community resilience and reduce vulnerability in spite of a changing climate.

Heat Death Associations with the built environment, social vulnerability and their interactions with rising temperature.

PubMed

Eisenman, David P; Wilhalme, Holly; Tseng, Chi-Hong; Chester, Mikhail; English, Paul; Pincetl, Stephanie; Fraser, Andrew; Vangala, Sitaram; Dhaliwal, Satvinder K

2016-09-01

In an extreme heat event, people can go to air-conditioned public facilities if residential air-conditioning is not available. Residences that heat slowly may also mitigate health effects, particularly in neighborhoods with social vulnerability. We explored the contributions of social vulnerability and these infrastructures to heat mortality in Maricopa County and whether these relationships are sensitive to temperature. Using Poisson regression modeling with heat-related mortality as the outcome, we assessed the interaction of increasing temperature with social vulnerability, access to publicly available air conditioned space, home air conditioning and the thermal properties of residences. As temperatures increase, mortality from heat-related illness increases less in census tracts with more publicly accessible cooled spaces. Mortality from all internal causes of death did not have this association. Building thermal protection was not associated with mortality. Social vulnerability was still associated with mortality after adjusting for the infrastructure variables. To reduce heat-related mortality, the use of public cooled spaces might be expanded to target the most vulnerable. Copyright © 2016 Elsevier Ltd. All rights reserved.

Situating Hazard Vulnerability: People's Negotiations with Wildfire Environments in the U.S. Southwest

NASA Astrophysics Data System (ADS)

Collins, Timothy W.; Bolin, Bob

2009-09-01

This article is based on a multimethod study designed to clarify influences on wildfire hazard vulnerability in Arizona’s White Mountains, USA. Findings reveal that multiple factors operating across scales generate socially unequal wildfire risks. At the household scale, conflicting environmental values, reliance on fire insurance and firefighting institutions, a lack of place dependency, and social vulnerability (e.g., a lack of financial, physical, and/or legal capacity to reduce risks) were found to be important influences on wildfire risk. At the regional-scale, the shift from a resource extraction to environmental amenity-based economy has transformed ecological communities, produced unequal social distributions of risks and resources, and shaped people’s social and environmental interactions in everyday life. While working-class locals are more socially vulnerable than amenity migrants to wildfire hazards, they have also been more active in attempting to reduce risks in the aftermath of the disastrous 2002 Rodeo-Chediski fire. Social tensions between locals and amenity migrants temporarily dissolved immediately following the disaster, only to be exacerbated by the heightened perception of risk and the differential commitment to hazard mitigation displayed by these groups over a 2-year study period. Findings suggest that to enhance wildfire safety, environmental managers should acknowledge the environmental benefits associated with hazardous landscapes, the incentives created by risk management programs, and the specific constraints to action for relevant social groups in changing human-environmental context.

Situating hazard vulnerability: people's negotiations with wildfire environments in the U.S. southwest.

PubMed

Collins, Timothy W; Bolin, Bob

2009-09-01

This article is based on a multimethod study designed to clarify influences on wildfire hazard vulnerability in Arizona's White Mountains, USA. Findings reveal that multiple factors operating across scales generate socially unequal wildfire risks. At the household scale, conflicting environmental values, reliance on fire insurance and firefighting institutions, a lack of place dependency, and social vulnerability (e.g., a lack of financial, physical, and/or legal capacity to reduce risks) were found to be important influences on wildfire risk. At the regional-scale, the shift from a resource extraction to environmental amenity-based economy has transformed ecological communities, produced unequal social distributions of risks and resources, and shaped people's social and environmental interactions in everyday life. While working-class locals are more socially vulnerable than amenity migrants to wildfire hazards, they have also been more active in attempting to reduce risks in the aftermath of the disastrous 2002 Rodeo-Chediski fire. Social tensions between locals and amenity migrants temporarily dissolved immediately following the disaster, only to be exacerbated by the heightened perception of risk and the differential commitment to hazard mitigation displayed by these groups over a 2-year study period. Findings suggest that to enhance wildfire safety, environmental managers should acknowledge the environmental benefits associated with hazardous landscapes, the incentives created by risk management programs, and the specific constraints to action for relevant social groups in changing human-environmental context.

Increased Cortical Activity in Binge Drinkers during Working Memory Task: A Preliminary Assessment through a Functional Magnetic Resonance Imaging Study

PubMed Central

Campanella, Salvatore; Peigneux, Philippe; Petit, Géraldine; Lallemand, Frédéric; Saeremans, Mélanie; Noël, Xavier; Metens, Thierry; Nouali, Mustapha; De Tiège, Xavier; De Witte, Philippe; Ward, Roberta; Verbanck, Paul

2013-01-01

Background Cerebral dysfunction is a common feature of both chronic alcohol abusers and binge drinkers. Here, we aimed to study whether, at equated behavioral performance levels, binge drinkers exhibited increased neural activity while performing simple cognitive tasks. Methods Thirty-two participants (16 binge drinkers and 16 matched controls) were scanned using functional magnetic resonance imaging (fMRI) while performing an n-back working memory task. In the control zero-back (N0) condition, subjects were required to press a button with the right hand when the number “2″ was displayed. In the two-back (N2) condition, subjects had to press a button when the displayed number was identical to the number shown two trials before. Results fMRI analyses revealed higher bilateral activity in the pre-supplementary motor area in binge drinkers than matched controls, even though behavioral performances were similar. Moreover, binge drinkers showed specific positive correlations between the number of alcohol doses consumed per occasion and higher activity in the dorsomedial prefrontal cortex, as well as between the number of drinking occasions per week and higher activity in cerebellum, thalamus and insula while performing the N2 memory task. Conclusions Binge alcohol consumption leads to possible compensatory cerebral changes in binge drinkers that facilitate normal behavioral performance. These changes in cerebral responses may be considered as vulnerability factors for developing adult substance use disorders. PMID:23638017

Partial genetic deletion of neuregulin 1 modulates the effects of stress on sensorimotor gating, dendritic morphology, and HPA axis activity in adolescent mice.

PubMed

Chohan, Tariq W; Boucher, Aurelie A; Spencer, Jarrah R; Kassem, Mustafa S; Hamdi, Areeg A; Karl, Tim; Fok, Sandra Y; Bennett, Maxwell R; Arnold, Jonathon C

2014-11-01

Stress has been linked to the pathogenesis of schizophrenia. Genetic variation in neuregulin 1 (NRG1) increases the risk of developing schizophrenia and may help predict which high-risk individuals will transition to psychosis. NRG1 also modulates sensorimotor gating, a schizophrenia endophenotype. We used an animal model to demonstrate that partial genetic deletion of Nrg1 interacts with stress to promote neurobehavioral deficits of relevance to schizophrenia. Nrg1 heterozygous (HET) mice displayed greater acute stress-induced anxiety-related behavior than wild-type (WT) mice. Repeated stress in adolescence disrupted the normal development of higher prepulse inhibition of startle selectively in Nrg1 HET mice but not in WT mice. Further, repeated stress increased dendritic spine density in pyramidal neurons of the medial prefrontal cortex (mPFC) selectively in Nrg1 HET mice. Partial genetic deletion of Nrg1 also modulated the adaptive response of the hypothalamic-pituitary-adrenal axis to repeated stress, with Nrg1 HET displaying a reduced repeated stress-induced level of plasma corticosterone than WT mice. Our results demonstrate that Nrg1 confers vulnerability to repeated stress-induced sensorimotor gating deficits, dendritic spine growth in the mPFC, and an abberant endocrine response in adolescence. © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Extending Validated Human Performance Models to Explore NextGen Concepts

NASA Technical Reports Server (NTRS)

Gore, Brian Francis; Hooey, Becky Lee; Mahlstedt, Eric; Foyle, David C.

2012-01-01

To meet the expected increases in air traffic demands, NASA and FAA are researching and developing Next Generation Air Transportation System (NextGen) concepts. NextGen will require substantial increases in the data available to pilots on the flight deck (e.g., weather,wake, traffic trajectory predictions, etc.) to support more precise and closely coordinated operations (e.g., self-separation, RNAV/RNP, and closely spaced parallel operations, CSPOs). These NextGen procedures and operations, along with the pilot's roles and responsibilities, must be designed with consideration of the pilot's capabilities and limitations. Failure to do so will leave the pilots, and thus the entire aviation system, vulnerable to error. A validated Man-machine Integration and design Analysis System (MIDAS) v5 model was extended to evaluate anticipated changes to flight deck and controller roles and responsibilities in NextGen approach and Land operations. Compared to conditions when the controllers are responsible for separation on decent to land phase of flight, the output from these model predictions suggest that the flight deck response time to detect the lead aircraft blunder will decrease, pilot scans to the navigation display will increase, and workload will increase.

Vulnerabilities of ecosystems across U.S. National Parks to biome shifts, wildfire changes, and invasive species due to climate change

NASA Astrophysics Data System (ADS)

Gonzalez, P.; Eigenbrod, F.; Early, R.; Wang, F.; Notaro, M.; Williams, J. W.

2016-12-01

U.S. national parks conserve globally unique biodiversity. Yet, historical impacts of climate change and future vulnerabilities threaten species and ecosystems across this system of protected areas. Spatial analyses of historical climate and downscaled future climate projections show climate trends across the system. Spatial analyses of vegetation and wildfire (using a dynamic global vegetation model), habitat fragmentation (using remote sensing-derived land cover), and invasive species introduction and establishment show patterns of future vulnerability across the 50 U.S. states and 412 U.S. national parks. Results reveal high historical and projected temperature increases and precipitation changes, projected increases of wildfire across western U.S. national parks, high vulnerability to biome shifts and habitat fragmentation of up to one-third of National Park System area, and high vulnerability to invasive species of one-ninth of National Park System area. Ecosystems in the Sierra Nevada, Cascade Range, desert Southwest, and Laurentian Great Lakes are highly vulnerable to upslope and poleward shifts of the North America sequence of biomes: temperate shrubland - temperate broadleaf forest - temperate mixed forest - temperate conifer forest - subalpine and boreal forest - alpine and tundra. These areas include Grand Canyon, Mount Rainier, and Yosemite National Parks. The southwestern U.S., including Grand Canyon and Sequoia National Parks, is vulnerable to increases in wildfire. The eastern and midwestern U.S., including Great Smokey Mountains and Voyageurs National Parks, are highly vulnerable to invasive species. These results identify vulnerable areas and potential refugia to help prioritize areas for future natural resource management actions and biodiversity conservation in U.S. national parks.

Conservation phylogeography: does historical diversity contribute to regional vulnerability in European tree frogs (Hyla arborea)?

PubMed

Dufresnes, Christophe; Wassef, Jérôme; Ghali, Karim; Brelsford, Alan; Stöck, Matthias; Lymberakis, Petros; Crnobrnja-Isailovic, Jelka; Perrin, Nicolas

2013-11-01

Documenting and preserving the genetic diversity of populations, which conditions their long-term survival, have become a major issue in conservation biology. The loss of diversity often documented in declining populations is usually assumed to result from human disturbances; however, historical biogeographic events, otherwise known to strongly impact diversity, are rarely considered in this context. We apply a multilocus phylogeographic study to investigate the late-Quaternary history of a tree frog (Hyla arborea) with declining populations in the northern and western part of its distribution range. Mitochondrial and nuclear polymorphisms reveal high genetic diversity in the Balkan Peninsula, with a spatial structure moulded by the last glaciations. While two of the main refugial lineages remained limited to the Balkans (Adriatic coast, southern Balkans), a third one expanded to recolonize Northern and Western Europe, loosing much of its diversity in the process. Our findings show that mobile and a priori homogeneous taxa may also display substructure within glacial refugia ('refugia within refugia') and emphasize the importance of the Balkans as a major European biodiversity centre. Moreover, the distribution of diversity roughly coincides with regional conservation situations, consistent with the idea that historically impoverished genetic diversity may interact with anthropogenic disturbances, and increase the vulnerability of populations. Phylogeographic models seem important to fully appreciate the risks of local declines and inform conservation strategies. © 2013 John Wiley & Sons Ltd.

Temporal and spatial changes in social vulnerability to natural hazards

PubMed Central

Cutter, Susan L.; Finch, Christina

2008-01-01

During the past four decades (1960–2000), the United States experienced major transformations in population size, development patterns, economic conditions, and social characteristics. These social, economic, and built-environment changes altered the American hazardscape in profound ways, with more people living in high-hazard areas than ever before. To improve emergency management, it is important to recognize the variability in the vulnerable populations exposed to hazards and to develop place-based emergency plans accordingly. The concept of social vulnerability identifies sensitive populations that may be less likely to respond to, cope with, and recover from a natural disaster. Social vulnerability is complex and dynamic, changing over space and through time. This paper presents empirical evidence on the spatial and temporal patterns in social vulnerability in the United States from 1960 to the present. Using counties as our study unit, we found that those components that consistently increased social vulnerability for all time periods were density (urban), race/ethnicity, and socioeconomic status. The spatial patterning of social vulnerability, although initially concentrated in certain geographic regions, has become more dispersed over time. The national trend shows a steady reduction in social vulnerability, but there is considerable regional variability, with many counties increasing in social vulnerability during the past five decades. PMID:18268336

US Vulnerability to Natural Disasters

NASA Astrophysics Data System (ADS)

van der Vink, G.; Apgar, S.; Batchelor, A.; Carter, C.; Gail, D.; Jarrett, A.; Levine, N.; Morgan, W.; Orlikowski, M.; Pray, T.; Raymar, M.; Siebert, A.; Shawa, T. W.; Wallace, C.

2002-05-01

Natural disasters result from the coincidence of natural events with the built environment. Our nation's infrastructure is growing at an exponential rate in many areas of high risk, and the Federal government's liability is increasing proportionally. By superimposing population density with predicted ground motion from earthquakes, historical hurricane tracks, historical tornado locations, and areas within the flood plain, we are able to identify locations of high vulnerability within the United States. We present a comprehensive map of disaster risk for the United States that is being produced for the Senate Natural Hazards Caucus. The map allows for the geographic comparison of natural disaster risk with past disaster declarations, the expenditure of Federal dollars for disaster relief, population increase, and variations of GDP. Every state is vulnerable to natural disasters. Although their frequency varies considerably, the annualized losses for disaster relief from hurricanes, earthquakes, and floods are approximately equivalent. While fast-growing states such as California and Florida remain highly vulnerable, changes in the occurrence of natural events combined with population increases are making areas such as Texas, North Carolina, and the East Coast increasingly vulnerable.

Design and fabrication of directional diffractive device on glass substrate for multiview holographic 3D display

NASA Astrophysics Data System (ADS)

Su, Yanfeng; Cai, Zhijian; Liu, Quan; Zou, Wenlong; Guo, Peiliang; Wu, Jianhong

2018-01-01

Multiview holographic 3D display based on the nano-grating patterned directional diffractive device can provide 3D images with high resolution and wide viewing angle, which has attracted considerable attention. However, the current directional diffractive device fabricated on the photoresist is vulnerable to damage, which will lead to the short service life of the device. In this paper, we propose a directional diffractive device on glass substrate to increase its service life. In the design process, the period and the orientation of the nano-grating at each pixel are carefully calculated accordingly by the predefined position of the viewing zone, and the groove parameters are designed by analyzing the diffraction efficiency of the nano-grating pixel on glass substrate. In the experiment, a 4-view photoresist directional diffractive device with a full coverage of pixelated nano-grating arrays is efficiently fabricated by using an ultraviolet continuously variable spatial frequency lithography system, and then the nano-grating patterns on the photoresist are transferred to the glass substrate by combining the ion beam etching and the reactive ion beam etching for controlling the groove parameters precisely. The properties of the etched glass device are measured under the illumination of a collimated laser beam with a wavelength of 532nm. The experimental results demonstrate that the light utilization efficiency is improved and optimized in comparison with the photoresist device. Furthermore, the fabricated device on glass substrate is easier to be replicated and of better durability and practicability, which shows great potential in the commercial applications of 3D display terminal.

An animal model of panic vulnerability with chronic disinhibition of the dorsomedial/perifornical hypothalamus

PubMed Central

Johnson, Philip L.; Shekhar, Anantha

2013-01-01

Panic disorder (PD) is a severe anxiety disorder characterized by susceptibility to induction of panic attacks by subthreshold interoceptive stimuli such as sodium lactate infusions or hypercapnia induction. Here we review a model of panic vulnerability in rats involving chronic inhibition of GABAergic tone in the dorsomedial/ perifornical hypothalamic (DMH/PeF) region that produces enhanced anxiety and freezing responses in fearful situations, as well as a vulnerability to displaying acute panic-like increases in cardioexcitation, respiration activity and “flight” associated behavior following subthreshold interoceptive stimuli that do not elicit panic responses in control rats. This model of panic vulnerability was developed over 15 years ago and has provided an excellent preclinical model with robust face, predictive and construct validity. The model recapitulates many of the phenotypics features of panic attacks associated with human panic disorder (face validity) including greater sensitivity to panicogenic stimuli demonstrated by sudden onset of anxiety and autonomic activation following an administration of a sub-threshold (i.e., do not usually induce panic in healthy subjects) stimulus such as sodium lactate, CO2, or yohimbine. The construct validity is supported by several key findings; DMH/PeF neurons regulate behavioral and autonomic components of a normal adaptive panic response, as well as being implicated in eliciting panic-like responses in humans. Additionally, Patients with PD have deficits in central GABA activity and pharmacological restoration of central GABA activity prevents panic attacks, consistent with this model. The model’s predictive validity is demonstrated by not only showing panic responses to several panic-inducing agents that elicit panic in patients with PD, but also by the positive therapeutic responses to clinically used agents such as alprazolam and antidepressants that attenuate panic attacks in patients. More importantly, this model has been utilized to discover novel drugs such as group II metabotropic glutamate agonists and a new class of translocator protein enhancers of GABA, both of which subsequently showed anti-panic properties in clinical trials. All of these data suggest that this preparation provides a strong preclinical model of some forms of human panic disorders. PMID:22484112

An analysis of the accessibility of video lottery terminals: the case of Montréal.

PubMed

Robitaille, Eric; Herjean, Patrick

2008-01-18

Researchers and public health officials in Canada, the United States and Australia have for some time noted broader geographic accessibility to gambling establishments, above all in socioeconomically underprivileged communities. This increase in availability could lead to more and more gambling problems. This article focuses, in an ecological perspective, in particular on a spatial analysis of the geographic accessibility of sites possessing a VLT permit in the Montréal area, i.e. Montréal Island, the South Shore and Laval, from the standpoint of the development of an indicator of the vulnerability (socioeconomic components and demographic components) to gambling of populations at the level of certain neighbourhood units (dissemination areas). With the recent development of geographic information systems (GIS), it is now possible to ascertain accessibility to services much more accurately, for example by taking into account the configuration of the road network. The findings of our analysis reveal widespread geographic accessibility to sites possessing a VLT permit in the downtown area and in pericentral districts. In some neighbourhood units, a site possessing a VLT permit may be within a three-minute walk. In the region studied overall, average walking time to a VLT site is nine minutes. Access to this type of service on foot is usually limited in the outskirts. However, a number of groups of sites possessing VLT permits are found along certain axial highways. According to local spatial self-correlation analyses, the findings suggest a significant link between walking accessibility to sites possessing VLT permits and the vulnerability of the communities. In a number of neighbourhood units with ready access to VLT's the populations display high vulnerability. These findings reveal that accessibility to sites possessing a VLT permit is often linked to the vulnerability (socioeconomic and demographic components) of communities. Reliance in our analyses on neighbourhood units with fairly small areas enabled us to emphasize the rectilinear dimension of the spatial distribution of sites possessing VLT permits. This is a significant link that public health officials must consider when elaborating programs to combat pathological gambling.

Efficiency vs. Security: Information Technology Consolidations - Resilience, Complexity, and Monoculture

DTIC Science & Technology

infrastructure. This may result in vulnerabilities not typically considered by policymakers, due to concentration and homogenization of critical...Resilience of a system is counter-proportional to the product of vulnerability and spectral radius; therefore, any increase in vulnerability, spectral

Identifying and tracking attacks on networks: C3I displays and related technologies

NASA Astrophysics Data System (ADS)

Manes, Gavin W.; Dawkins, J.; Shenoi, Sujeet; Hale, John C.

2003-09-01

Converged network security is extremely challenging for several reasons; expanded system and technology perimeters, unexpected feature interaction, and complex interfaces all conspire to provide hackers with greater opportunities for compromising large networks. Preventive security services and architectures are essential, but in and of themselves do not eliminate all threat of compromise. Attack management systems mitigate this residual risk by facilitating incident detection, analysis and response. There are a wealth of attack detection and response tools for IP networks, but a dearth of such tools for wireless and public telephone networks. Moreover, methodologies and formalisms have yet to be identified that can yield a common model for vulnerabilities and attacks in converged networks. A comprehensive attack management system must coordinate detection tools for converged networks, derive fully-integrated attack and network models, perform vulnerability and multi-stage attack analysis, support large-scale attack visualization, and orchestrate strategic responses to cyber attacks that cross network boundaries. We present an architecture that embodies these principles for attack management. The attack management system described engages a suite of detection tools for various networking domains, feeding real-time attack data to a comprehensive modeling, analysis and visualization subsystem. The resulting early warning system not only provides network administrators with a heads-up cockpit display of their entire network, it also supports guided response and predictive capabilities for multi-stage attacks in converged networks.

Topological robustness analysis of protein interaction networks reveals key targets for overcoming chemotherapy resistance in glioma

NASA Astrophysics Data System (ADS)

Azevedo, Hátylas; Moreira-Filho, Carlos Alberto

2015-11-01

Biological networks display high robustness against random failures but are vulnerable to targeted attacks on central nodes. Thus, network topology analysis represents a powerful tool for investigating network susceptibility against targeted node removal. Here, we built protein interaction networks associated with chemoresistance to temozolomide, an alkylating agent used in glioma therapy, and analyzed their modular structure and robustness against intentional attack. These networks showed functional modules related to DNA repair, immunity, apoptosis, cell stress, proliferation and migration. Subsequently, network vulnerability was assessed by means of centrality-based attacks based on the removal of node fractions in descending orders of degree, betweenness, or the product of degree and betweenness. This analysis revealed that removing nodes with high degree and high betweenness was more effective in altering networks’ robustness parameters, suggesting that their corresponding proteins may be particularly relevant to target temozolomide resistance. In silico data was used for validation and confirmed that central nodes are more relevant for altering proliferation rates in temozolomide-resistant glioma cell lines and for predicting survival in glioma patients. Altogether, these results demonstrate how the analysis of network vulnerability to topological attack facilitates target prioritization for overcoming cancer chemoresistance.

Circadian clock and cardiac vulnerability: A time stamp on multi-scale neuroautonomic regulation

NASA Astrophysics Data System (ADS)

Ivanov, Plamen Ch.

2005-03-01

Cardiovascular vulnerability displays a 24-hour pattern with a peak between 9AM and 11AM. This daily pattern in cardiac risk is traditionally attributed to external factors including activity levels and sleep-wake cycles. However,influences from the endogenous circadian pacemaker independent from behaviors may also affect cardiac control. We investigate heartbeat dynamics in healthy subjects recorded throughout a 10-day protocol wherein the sleep/wake and behavior cycles are desynchronized from the endogenous circadian cycle,enabling assessment of circadian factors while controlling for behavior-related factors. We demonstrate that the scaling exponent characterizing temporal correlations in heartbeat dynamics over multiple time scales does exhibit a significant circadian rhythm with a sharp peak at the circadian phase corresponding to the period 9-11AM, and that this rhythm is independent from scheduled behaviors and mean heart rate. Our findings of strong circadian rhythms in the multi-scale heartbeat dynamics of healthy young subjects indicate that the underlying mechanism of cardiac regulation is strongly influenced by the endogenous circadian pacemaker. A similar circadian effect in vulnerable individuals with underlying cardiovascular disease would contribute to the morning peak of adverse cardiac events observed in epidemiological studies.

Community vulnerability to health impacts of wildland fire smoke exposure

EPA Science Inventory

Identifying communities vulnerable to adverse health effects from exposure to wildfire smoke may help prepare responses, increase the resilience to smoke and improve public health outcomes during smoke days. We developed a Community Health-Vulnerability Index (CHVI) based on fact...

MINIMIZING THE VULNERABILITY OF WATER SUPPLIES TO NATURAL AND TERRORIST THREATS

EPA Science Inventory

There is increasing concern that drinking water utilities may be vulnerable to attacks by terrorists. In the US the President's Commission on Critical Infrastructure Protection has concluded the US drinking water utilities are vulnerable to physical, cyber and biological terroris...

Central and rear-edge populations can be equally vulnerable to warming

NASA Astrophysics Data System (ADS)

Bennett, Scott; Wernberg, Thomas; Arackal Joy, Bijo; de Bettignies, Thibaut; Campbell, Alexandra H.

2015-12-01

Rear (warm) edge populations are often considered more susceptible to warming than central (cool) populations because of the warmer ambient temperatures they experience, but this overlooks the potential for local variation in thermal tolerances. Here we provide conceptual models illustrating how sensitivity to warming is affected throughout a species' geographical range for locally adapted and non-adapted populations. We test these models for a range-contracting seaweed using observations from a marine heatwave and a 12-month experiment, translocating seaweeds among central, present and historic range edge locations. Growth, reproductive development and survivorship display different temperature thresholds among central and rear-edge populations, but share a 2.5 °C anomaly threshold. Range contraction, therefore, reflects variation in local anomalies rather than differences in absolute temperatures. This demonstrates that warming sensitivity can be similar throughout a species geographical range and highlights the importance of incorporating local adaptation and acclimatization into climate change vulnerability assessments.

Examining mechanisms in the final stages of the elimination of boreal tree species on vulnerable sites in boreal Alaska

NASA Astrophysics Data System (ADS)

Juday, G. P.; Jess, R.; Alix, C. M.; Verbyla, D.

2015-12-01

The boreal forest of Alaska and western Canada exist in a complex mosaic of environments determined by elevation, aspect of exposure, and longitudinal and latitudinal gradients of change from warm, dry continental to maritime-influenced conditions. This forest region is largely made up of trees with two growth responses to temperature increases. Trees that decrease in growth are termed negative responders, and occupy warm, dry sites at low elevations. Trees that increase in radial growth are termed positive responders, and are largely in western Alaska, and at high elevation of the Brooks and Alaska Ranges. Since the Pacific climate regime shift of the 1970s, mature trees at low elevation sites have experienced increasing climate stress in several quasi-decadal cycles of intensifying drought stress. NDVI trends and tree ring records demonstrating radial growth decline are coherent. Phenological monitoring of spruce height growth also indicates that depletion of spring soil moisture is a critical process driven by the interaction of early warm season temperatures and precipitation. Novel biotic disturbance agents including spruce budworm, outbreaks of which are triggered by warm temperature anomalies related to its biology, and aspen leaf miner are depressing realized growth below climatically predicted levels, suggesting a pathway by which tree death is likely to occur before absolute temperature limits. As a result, insect outbreaks are degrading the otherwise strong long-term climate signal in Alaska boreal trees. However, young tree (> 40 yrs.) regeneration generally does not yet display the symptoms of acute high temperature stress. Overall, on these vulnerable sites, if temperature increases similar to the past 40 years continue, long term survival prospects are questionable because the climate conditions would be outside the limits that have historically defined the species ranges of aspen, Alaska birch, and black and white spruce.

A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear

PubMed Central

Meyer, Retsina M.; Burgos-Robles, Anthony; Liu, Elizabeth; Correia, Susana S.; Goosens, Ki A.

2014-01-01

Hormones in the hypothalamus-pituitary-adrenal (HPA) axis mediate many of the bodily responses to stressors, yet there is not a clear relationship between the levels of these hormones and stress-associated mental illnesses such as post-traumatic stress disorder (PTSD). Therefore, other hormones are likely to be involved in this effect of stress. Here we used a rodent model of PTSD in which rats repeatedly exposed to a stressor display heightened fear learning following auditory Pavlovian fear conditioning. Our results show that stress-related increases in circulating ghrelin, a peptide hormone, are necessary and sufficient for stress-associated vulnerability to exacerbated fear learning and these actions of ghrelin occur in the amygdala. Importantly, these actions are also independent of the classic HPA stress axis. Repeated systemic administration of a ghrelin receptor agonist enhanced fear memory but did not increase either corticotropin releasing factor (CRF) or corticosterone. Repeated intra-amygdala infusion of a ghrelin receptor agonist produced a similar enhancement of fear memory. Ghrelin receptor antagonism during repeated stress abolished stress-related enhancement of fear memory without blunting stress-induced corticosterone release. We also examined links between ghrelin and growth hormone (GH), a major downstream effector of the ghrelin receptor. GH protein was upregulated in the amygdala following chronic stress, and its release from amygdala neurons was increased by ghrelin receptor stimulation. Virus-mediated overexpression of GH in the amygdala was also sufficient to increase fear. Finally, virus-mediated overexpression of a GH receptor antagonist was sufficient to block the fear enhancing effects of repeated ghrelin receptor stimulation. Thus, ghrelin requires GH in the amygdala to exert fear-enhancing effects. These results suggest that ghrelin mediates a novel branch of the stress response and highlight a previously unrecognized role for ghrelin and growth hormone in maladaptive changes following prolonged stress. PMID:24126924

[Characteristics of temporal-spatial differentiation in landscape pattern vulnerability in Nansihu Lake wetland, China.

PubMed

Liang, Jia Xin; Li, Xin Ju

2018-02-01

With remote sensing images from 1985, 2000 Lantsat 5 TM and 2015 Lantsat 8 OLI as data sources, we tried to select the suitable research scale and examine the temporal-spatial diffe-rentiation with such scale in the Nansihu Lake wetland by using landscape pattern vulnerability index constructed by sensitivity index and adaptability index, and combined with space statistics such as semivariogram and spatial autocorrelation. The results showed that 1 km × 1 km equidistant grid was the suitable research scale, which could eliminate the influence of spatial heterogeneity induced by random factors. From 1985 to 2015, the landscape pattern vulnerability in the Nansihu Lake wetland deteriorated gradually. The high-risk area of landscape pattern vulnerability dramatically expanded with time. The spatial heterogeneity of landscape pattern vulnerability increased, and the influence of non-structural factors on landscape pattern vulnerability strengthened. Spatial variability affected by spatial autocorrelation slightly weakened. Landscape pattern vulnerability had strong general spatial positive correlation, with the significant form of spatial agglomeration. The positive spatial autocorrelation continued to increase and the phenomenon of spatial concentration was more and more obvious over time. The local autocorrelation mainly based on high-high accumulation zone and low-low accumulation zone had stronger spatial autocorrelation among neighboring space units. The high-high accumulation areas showed the strongest level of significance, and the significant level of low-low accumulation zone increased with time. Natural factors, such as temperature and precipitation, affected water-level and landscape distribution, and thus changed the landscape patterns vulnerability of Nansihu Lake wetland. The dominant driver for the deterioration of landscape patterns vulnerability was human activities, including social economy activity and policy system.

Evaluation of Measurement Tools for Tobacco Product Displays: Is there an App for that?

PubMed Central

Combs, Todd B.; Moreland-Russell, Sarah; Roche, Jason

2015-01-01

Tobacco product displays are a pervasive presence in convenience stores, supermarkets, pharmacies, and other retailers nationwide. The influence that tobacco product displays have on purchases and tobacco product initiation, particularly on young people and other vulnerable populations, is well known. An objective measurement tool that is valid, reliable, and feasible to use is needed to assess product displays in the retail setting. This study reports on the relative accuracy of various tools that measure area and/or distance in photos and thus could be applied to product displays. We compare results of repeated trials using five tools. Three tools are smartphone apps that measure objects in photos taken on the device; these are narrowed down from a list of 284 candidate apps. Another tool uses photos taken with any device and calculates relative area via a built-in function in the Microsoft Office Suite. The fifth uses photos taken with the Narrative Clip, a “life-logging” wearable camera. To evaluate validity and reliability, we assess each instrument's measurements and calculate intra-class correlation coefficients. Mean differences between observed measurements (via tape measure) and those from the five tools range from just over one square foot to just over two square feet. Most instruments produce reliable estimates though some are sensitive to the size of the display. Results of this study indicate need for future research to test innovative measurement tools. This paper also solicits further discussion on how best to transform anecdotal knowledge of product displays as targeted and disproportionate marketing tactics into a scientific evidence base for public policy change. PMID:29188220

Perceptions of vulnerability to a future outbreak: a study of horse managers affected by the first Australian equine influenza outbreak

PubMed Central

2013-01-01

Background A growing body of work shows the benefits of applying social cognitive behavioural theory to investigate infection control and biosecurity practices. Protection motivation theory has been used to predict protective health behaviours. The theory outlines that a perception of a lack of vulnerability to a disease contributes to a reduced threat appraisal, which results in poorer motivation, and is linked to poorer compliance with advised health protective behaviours. This study, conducted following the first-ever outbreak of equine influenza in Australia in 2007, identified factors associated with horse managers’ perceived vulnerability to a future equine influenza outbreak. Results Of the 200 respondents, 31.9% perceived themselves to be very vulnerable, 36.6% vulnerable and 31.4% not vulnerable to a future outbreak of equine influenza. Multivariable logistic regression modelling revealed that managers involved in horse racing and those on rural horse premises perceived themselves to have low levels of vulnerability. Managers of horse premises that experienced infection in their horses in 2007 and those seeking infection control information from specific sources reported increased levels of perceived vulnerability to a future outbreak. Conclusion Different groups across the horse industry perceived differing levels of vulnerability to a future outbreak. Increased vulnerability contributes to favourable infection control behaviour and hence these findings are important for understanding uptake of recommended infection control measures. Future biosecurity communication strategies should be delivered through information sources suitable for the horse racing and rural sectors. PMID:23902718

Perceptions of vulnerability to a future outbreak: a study of horse managers affected by the first Australian equine influenza outbreak.

PubMed

Schemann, Kathrin; Firestone, Simon M; Taylor, Melanie R; Toribio, Jenny-Ann L M L; Ward, Michael P; Dhand, Navneet K

2013-07-31

A growing body of work shows the benefits of applying social cognitive behavioural theory to investigate infection control and biosecurity practices. Protection motivation theory has been used to predict protective health behaviours. The theory outlines that a perception of a lack of vulnerability to a disease contributes to a reduced threat appraisal, which results in poorer motivation, and is linked to poorer compliance with advised health protective behaviours. This study, conducted following the first-ever outbreak of equine influenza in Australia in 2007, identified factors associated with horse managers' perceived vulnerability to a future equine influenza outbreak. Of the 200 respondents, 31.9% perceived themselves to be very vulnerable, 36.6% vulnerable and 31.4% not vulnerable to a future outbreak of equine influenza. Multivariable logistic regression modelling revealed that managers involved in horse racing and those on rural horse premises perceived themselves to have low levels of vulnerability. Managers of horse premises that experienced infection in their horses in 2007 and those seeking infection control information from specific sources reported increased levels of perceived vulnerability to a future outbreak. Different groups across the horse industry perceived differing levels of vulnerability to a future outbreak. Increased vulnerability contributes to favourable infection control behaviour and hence these findings are important for understanding uptake of recommended infection control measures. Future biosecurity communication strategies should be delivered through information sources suitable for the horse racing and rural sectors.

Prenatal drug exposure effects on subsequent vulnerability to drug abuse.

PubMed

Glantz, Meyer D; Chambers, Jessica Campbell

2006-01-01

Research has shown that both prenatal alcohol and tobacco exposure are associated with increased risk of significant adverse medical, developmental, and behavioral outcomes including substance abuse. Research on the outcomes of prenatal exposure to illicit drugs (PNDE) has also found increased physical and behavioral problems for gestationally drug-exposed children. However, a clear picture has not emerged on whether the consequences of PNDE are independent from those associated with having a substance abusing parent and whether PNDE increases vulnerability to drug abuse. Because of its typical co-occurrence with factors inherent in having a drug-abusing parent, PNDE is at least a marker of significant increased risk for a range of negative outcomes including greater vulnerability to substance abuse. Although a review of the relevant research literatures indicates that the direct consequences of PNDE appear to be generally both subtle and nonglobal, PNDE does appear to have negative developmental and behavioral outcomes, and there is evidence that it is a modest direct contributor to increased substance abuse vulnerability.

Patterns of health care utilization among vulnerable populations in Central Texas using data from a regional health information exchange.

PubMed

Schiefelbein, Emily L; Olson, Jerome A; Moxham, Jamie D

2014-02-01

Describe patterns of health care utilization among vulnerable subgroups of an underserved population and identify populations that could benefit from interventions to reduce health care costs and improve quality of care. Health Information Exchange data focused on underserved patients was used to estimate the risk of an emergency department (ED) or inpatient (IP) visit among vulnerable patients. Approximately 20.9% of the population was vulnerable, with behavioral health being the most predominant. Homeless, disabled, and severe behavioral health patients had an increased risk of ED utilization. Behavioral health, disabled, and near elderly patients had an increased risk of IP utilization. Inpatient risk was even greater for patients with multiple vulnerabilities. Improved primary care services are needed to address both the mental and physical needs of vulnerable populations, particularly people with severe behavioral health conditions. Improved access to services may help reduce the costly burden of providing hospital-based care.

Transactional relationships among cognitive vulnerabilities, stressors, and depressive symptoms in adolescence.

PubMed

Calvete, Esther; Orue, Izaskun; Hankin, Benjamin L

2013-04-01

The transactional cognitive vulnerability to stress model Hankin & Abramson (Psychological Bulletin, 127:773-796, 2001) extends the traditional diathesis-stress model by proposing that the relationships among cognitions, depressive symptoms, and stressors are dynamic and bidirectional. In this study three different pathways among these variables were assessed simultaneously: (1) cognitive vulnerabilities and stressors as predictors of depressive symptoms (vulnerability model), (2) depressive symptoms and cognitive vulnerabilities as predictors of stressors (stress generation model), and (3) depressive symptoms and stressors as predictors of cognitive vulnerabilities (consequence model). A fully cross-lagged design panel was employed with 1,187 adolescents (545 girls and 642 boys, Mean Age = 13.42 years) who were assessed at two time points separated by 6 months. They completed measures of cognitive vulnerabilities (maladaptive schema domains and negative inferential style), stressors, and depressive symptoms. Inferential style and schemas of the disconnection and rejection domain predicted prospective increases in depressive symptoms. Initial levels of depressive symptoms and most cognitive vulnerabilities predicted greater stress generation. Initial levels of stressors and depressive symptoms predicted an increase in negative inferential style and maladaptive schema domains over time. These bidirectional relationships were mostly similar for boys and girls, although there were a few gender differences. The findings support a transactional model with reciprocal relationships among stress, depressive symptoms, and cognitive vulnerabilities. Transactional implications for depression interventions among adolescents are discussed.

Role of Livelihood Capital in Reducing Climatic Vulnerability: Insights of Australian Wheat from 1990-2010.

PubMed

Huai, Jianjun

2016-01-01

In many agricultural countries, development of rural livelihood through increasing capital is a major regional policy to adapt to climate change. However, the role of livelihood capital in reducing climatic vulnerability is uncertain. This study assesses vulnerability and identifies the effects of common capital indicators on it, using Australian wheat as an example. We calculate exposure (a climate index) and sensitivity (a wheat failure index) to measure vulnerability and classify the resilient and sensitive cases, and express adaptive capacity through financial, human, natural, physical, and social capital indicators for 12 regions in the Australian wheat-sheep production zone from 1991-2010. We identify relationships between 12 indicators of five types of capital and vulnerability with t-tests and six logistic models considering the capital indicator itself, its first-order lag and its square as dependent variables to test the hypothesis that a high level of each capital metric results in low vulnerability. Through differing adaptive capacities between resilient and sensitive groups, we found that only four of the 12 (e.g., the access to finance, cash income level, total crop gross revenues, and family share of farm income) relate to vulnerability, which challenges the hypothesis that increasing capital reduces vulnerability. We conclude that further empirical reexaminations are required to test the relationships between capital measures and vulnerability under the sustainable livelihood framework (SLF).

Role of Livelihood Capital in Reducing Climatic Vulnerability: Insights of Australian Wheat from 1990–2010

PubMed Central

Huai, Jianjun

2016-01-01

In many agricultural countries, development of rural livelihood through increasing capital is a major regional policy to adapt to climate change. However, the role of livelihood capital in reducing climatic vulnerability is uncertain. This study assesses vulnerability and identifies the effects of common capital indicators on it, using Australian wheat as an example. We calculate exposure (a climate index) and sensitivity (a wheat failure index) to measure vulnerability and classify the resilient and sensitive cases, and express adaptive capacity through financial, human, natural, physical, and social capital indicators for 12 regions in the Australian wheat–sheep production zone from 1991–2010. We identify relationships between 12 indicators of five types of capital and vulnerability with t-tests and six logistic models considering the capital indicator itself, its first-order lag and its square as dependent variables to test the hypothesis that a high level of each capital metric results in low vulnerability. Through differing adaptive capacities between resilient and sensitive groups, we found that only four of the 12 (e.g., the access to finance, cash income level, total crop gross revenues, and family share of farm income) relate to vulnerability, which challenges the hypothesis that increasing capital reduces vulnerability. We conclude that further empirical reexaminations are required to test the relationships between capital measures and vulnerability under the sustainable livelihood framework (SLF). PMID:27022910

Vulnerability to cavitation, hydraulic efficiency, growth and survival in an insular pine (Pinus canariensis)

PubMed Central

López, Rosana; López de Heredia, Unai; Collada, Carmen; Cano, Francisco Javier; Emerson, Brent C.; Cochard, Hervé; Gil, Luis

2013-01-01

Background and Aims It is widely accepted that hydraulic failure due to xylem embolism is a key factor contributing to drought-induced mortality in trees. In the present study, an attempt is made to disentangle phenotypic plasticity from genetic variation in hydraulic traits across the entire distribution area of a tree species to detect adaptation to local environments. Methods A series of traits related to hydraulics (vulnerability to cavitation and hydraulic conductivity in branches), growth performance and leaf mass per area were assessed in eight Pinus canariensis populations growing in two common gardens under contrasting environments. In addition, the neutral genetic variability (FST) and the genetic differentiation of phenotypic variation (QST) were compared in order to identify the evolutionary forces acting on these traits. Key Results The variability for hydraulic traits was largely due to phenotypic plasticity. Nevertheless, the vulnerability to cavitation displayed a significant genetic variability (approx. 5 % of the explained variation), and a significant genetic × environment interaction (between 5 and 19 % of the explained variation). The strong correlation between vulnerability to cavitation and survival in the xeric common garden (r = –0·81; P < 0·05) suggests a role for the former in the adaptation to xeric environments. Populations from drier sites and higher temperature seasonality were less vulnerable to cavitation than those growing at mesic sites. No trade-off between xylem safety and efficiency was detected. QST of parameters of the vulnerability curve (0·365 for P50 and the slope of the vulnerability curve and 0·452 for P88) differed substantially from FST (0·091), indicating divergent selection. In contrast, genetic drift alone was found to be sufficient to explain patterns of differentiation for xylem efficiency and growth. Conclusions The ability of P. canariensis to inhabit a wide range of ecosystems seemed to be associated with high phenotypic plasticity and some degree of local adaptations of xylem and leaf traits. Resistance to cavitation conferred adaptive potential for this species to adapt successfully to xeric conditions. PMID:23644361

Software Security Knowledge: CWE. Knowing What Could Make Software Vulnerable to Attack

DTIC Science & Technology

2011-05-01

shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1...Buffer • CWE-642: External Control of Critical State Data • CWE-73: External Control of File Name or Path • CWE-426: Untrusted Search Path • CWE...94: Failure to Control Generation of Code (aka ’Code Injection’) • CWE-494: Download of Code Without Integrity Check • CWE-404: Improper Resource

How to manage future groundwater resource of China under climate change and urbanization: An optimal stage investment design from modern portfolio theory.

PubMed

Hua, Shanshan; Liang, Jie; Zeng, Guangming; Xu, Min; Zhang, Chang; Yuan, Yujie; Li, Xiaodong; Li, Ping; Liu, Jiayu; Huang, Lu

2015-11-15

Groundwater management in China has been facing challenges from both climate change and urbanization and is considered as a national priority nowadays. However, unprecedented uncertainty exists in future scenarios making it difficult to formulate management planning paradigms. In this paper, we apply modern portfolio theory (MPT) to formulate an optimal stage investment of groundwater contamination remediation in China. This approach generates optimal weights of investment to each stage of the groundwater management and helps maximize expected return while minimizing overall risk in the future. We find that the efficient frontier of investment displays an upward-sloping shape in risk-return space. The expected value of groundwater vulnerability index increases from 0.6118 to 0.6230 following with the risk of uncertainty increased from 0.0118 to 0.0297. If management investment is constrained not to exceed certain total cost until 2050 year, the efficient frontier could help decision makers make the most appropriate choice on the trade-off between risk and return. Copyright © 2015 Elsevier Ltd. All rights reserved.

Altered subjective reward valuation among drug-deprived heavy marijuana users: Aversion to uncertainty

PubMed Central

Hefner, Kathryn R.; Starr, Mark. J.; Curtin, John. J.

2015-01-01

Marijuana is the most commonly used illicit drug in the United States and its use is rising. Nonetheless, scientific efforts to clarify the risk for addiction and other harm associated with marijuana use have been lacking. Maladaptive decision-making is a cardinal feature of addiction that is likely to emerge in heavy users. In particular, distorted subjective reward valuation related to homeostatic or allostatic processes has been implicated for many drugs of abuse. Selective changes in responses to uncertainty have been observed in response to intoxication and deprivation from various drugs of abuse. To assess for these potential neuroadaptive changes in reward valuation associated with marijuana deprivation, we examined the subjective value of uncertain and certain rewards among deprived and non-deprived heavy marijuana users in a behavioral economics decision-making task. Deprived users displayed reduced valuation of uncertain rewards, particularly when these rewards were more objectively valuable. This uncertainty aversion increased with increasing quantity of marijuana use. These results suggest comparable decision-making vulnerability from marijuana use as other drugs of abuse, and highlights targets for intervention. PMID:26595464

A GIS-based methodology for the estimation of potential volcanic damage and its application to Tenerife Island, Spain

NASA Astrophysics Data System (ADS)

Scaini, C.; Felpeto, A.; Martí, J.; Carniel, R.

2014-05-01

This paper presents a GIS-based methodology to estimate damages produced by volcanic eruptions. The methodology is constituted by four parts: definition and simulation of eruptive scenarios, exposure analysis, vulnerability assessment and estimation of expected damages. Multi-hazard eruptive scenarios are defined for the Teide-Pico Viejo active volcanic complex, and simulated through the VORIS tool. The exposure analysis identifies the elements exposed to the hazard at stake and focuses on the relevant assets for the study area. The vulnerability analysis is based on previous studies on the built environment and complemented with the analysis of transportation and urban infrastructures. Damage assessment is performed associating a qualitative damage rating to each combination of hazard and vulnerability. This operation consists in a GIS-based overlap, performed for each hazardous phenomenon considered and for each element. The methodology is then automated into a GIS-based tool using an ArcGIS® program. Given the eruptive scenarios and the characteristics of the exposed elements, the tool produces expected damage maps. The tool is applied to the Icod Valley (North of Tenerife Island) which is likely to be affected by volcanic phenomena in case of eruption from both the Teide-Pico Viejo volcanic complex and North-West basaltic rift. Results are thematic maps of vulnerability and damage that can be displayed at different levels of detail, depending on the user preferences. The aim of the tool is to facilitate territorial planning and risk management in active volcanic areas.

A Prospective Test of Cognitive Vulnerability Models of Depression With Adolescent Girls

PubMed Central

Bohon, Cara; Stice, Eric; Burton, Emily; Fudell, Molly; Nolen-Hoeksema, Susan

2009-01-01

This study sought to provide a more rigorous prospective test of two cognitive vulnerability models of depression with longitudinal data from 496 adolescent girls. Results supported the cognitive vulnerability model in that stressors predicted future increases in depressive symptoms and onset of clinically significant major depression for individuals with a negative attributional style, but not for those with a positive attributional style, although these effects were small. This model appeared to be specific to depression, in that it did not predict future increases in bulimia nervosa or substance abuse symptoms. In contrast, results did not support the integrated cognitive vulnerability self-esteem model that asserts stressors should only predict increased depression for individuals with a confluence of negative attributional style and low self-esteem, and this model did not appear to be specific to depression. PMID:18328873

Soil development along a glacial chronosequence (Pré de Bar glacier, NW Italy)

NASA Astrophysics Data System (ADS)

Letey, Stéphanie; Freppaz, Michele; Filippa, Gianluca; Stanchi, Silvia; Cerli, Chiara; Pogliotti, Paolo; Zanini, Ermanno

2010-05-01

After the maximum expansion phase of the Little Ice Age, soils located in proglacial areas in the Italian Alps evolved over a time span of about 190 years. In the future, as a consequence of climate change, additional areas will become ice-free and therefore subject to pedogenesis. In such conditions, ice retreat time and topography are expected to play a major role among soil formation factors. Due to extreme environmental characteristics, soil evolution will be rather slow, and heavily influenced by severe soil loss phenomena (e.g. water erosion due to extreme rainfall event and snowmelt, avalanche erosion). We investigated the soil formation along a glacial chronosequence of an Alpine glacier foreland. The Pré de Bar glacier is located in North West Italy (Aosta Valley Region), in the Mont Blanc massif, between 3750 and 2150 m a.s.l. and it covers an area of 340 ha. The glacier was chosen because of the availability of old photographs documenting the glacier retreat phases starting from 1820. At the present time, the cumulative retreat length of the Pré de Bar glacier has reached 1600 m. Along this length, sampling sites were established at 6 successional stages from 6 to 189 years since deglaciation, from 2100 to 1880 m a.s.l.. Soil profiles were opened and sampled according to diagnostic horizons, then they were characterized by means of standard chemical and physical methods. Moreover, as recently deglaciated soils, characterized by incipient pedogenesis, may be particularly vulnerable from the physical point of view, the Atterberg Limits (LL, Liquid Limit; and PL, Plastic Limit) and the WAS (Water Aggregate Stability) index were determined, as indicators of soil physical quality. Soil samples were also subjected to organic matter density fractionation to assess the role of organic C in structure development. All the analyzed soils were classified as Lythic Cryorthents (higher elevation) or Typic Cryorthents (lower elevation) (USDA - Soil Taxonomy), with depth ranging between 25 and 40 cm, regularly increasing with years since deglaciation. A similar trend was observed for the organic C content. A true organo-mineral horizon (A) was first identified approximately 65 years after deglaciation. We observed a general increase of soil physical quality along the chronosequence. Recently deglaciated soils displayed higher vulnerability to aggregate and consistence losses, i.e. lower LL and scarce or no plasticity, while the profiles at lower altitudes, on the oldest surfaces, displayed better properties, i.e. more developed structure and consistence, even for relatively young soils. Therefore in this area the stabilization of the material after the deglaciation resulted relatively fast, with a reduction of its vulnerability to mass and erosive processes, through soil development. This research is carried out as part of "PERMANET - Permafrost Long-Term Monitoring Network", a EU co-funded Interreg Project under the Alpine Space Programme 2007-2013.

The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers.

PubMed

Tury, Sandrine; Assayag, Franck; Bonin, Florian; Chateau-Joubert, Sophie; Servely, Jean-Luc; Vacher, Sophie; Becette, Véronique; Caly, Martial; Rapinat, Audrey; Gentien, David; de la Grange, Pierre; Schnitzler, Anne; Lallemand, François; Marangoni, Elisabetta; Bièche, Ivan; Callens, Céline

2018-06-07

To ensure their high proliferation rate, tumor cells display an iron metabolic disorder with increased iron needs, making them more susceptible to iron deprivation. This vulnerability could be a therapeutic target. In breast cancers, the development of new therapeutic approaches is urgently needed for patients with triple negative tumors which frequently relapse after chemotherapy and suffer from a lack of targeted therapies. In this work, we demonstrated that deferasirox (DFX) synergizes with standard chemotherapeutic agents such as with doxorubicin, cisplatin and carboplatin to inhibit cell proliferation and induce apoptosis and autophagy in triple-negative breast cancer (TNBC) cell lines. Moreover, the combination of DFX with doxorubicin and cyclophosphamide delayed recurrences in breast cancer patient-derived xenografts without increasing the side-effects of chemotherapies alone or altering global iron storage of mice. Antitumor synergy of DFX and doxorubicin seems to involve down-regulation of the PI3K and NF-κB pathways. Iron deprivation in combination with chemotherapy could thus help to improve the effectiveness of chemotherapy in TNBC patients without increasing toxicities. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

A Prospective Test of Cognitive Vulnerability Models of Depression with Adolescent Girls

ERIC Educational Resources Information Center

Bohon, Cara; Stice, Eric; Burton, Emily; Fudell, Molly; Nolen-Hoeksema, Susan

2008-01-01

This study sought to provide a more rigorous prospective test of two cognitive vulnerability models of depression with longitudinal data from 496 adolescent girls. Results supported the cognitive vulnerability model in that stressors predicted future increases in depressive symptoms and onset of clinically significant major depression for…

A cross-sectional, randomized cluster sample survey of household vulnerability to extreme heat among slum dwellers in ahmedabad, india.

PubMed

Tran, Kathy V; Azhar, Gulrez S; Nair, Rajesh; Knowlton, Kim; Jaiswal, Anjali; Sheffield, Perry; Mavalankar, Dileep; Hess, Jeremy

2013-06-18

Extreme heat is a significant public health concern in India; extreme heat hazards are projected to increase in frequency and severity with climate change. Few of the factors driving population heat vulnerability are documented, though poverty is a presumed risk factor. To facilitate public health preparedness, an assessment of factors affecting vulnerability among slum dwellers was conducted in summer 2011 in Ahmedabad, Gujarat, India. Indicators of heat exposure, susceptibility to heat illness, and adaptive capacity, all of which feed into heat vulnerability, was assessed through a cross-sectional household survey using randomized multistage cluster sampling. Associations between heat-related morbidity and vulnerability factors were identified using multivariate logistic regression with generalized estimating equations to account for clustering effects. Age, preexisting medical conditions, work location, and access to health information and resources were associated with self-reported heat illness. Several of these variables were unique to this study. As sociodemographics, occupational heat exposure, and access to resources were shown to increase vulnerability, future interventions (e.g., health education) might target specific populations among Ahmedabad urban slum dwellers to reduce vulnerability to extreme heat. Surveillance and evaluations of future interventions may also be worthwhile.

Global-scale river flood vulnerability in the last 50 years.

PubMed

Tanoue, Masahiro; Hirabayashi, Yukiko; Ikeuchi, Hiroaki

2016-10-26

The impacts of flooding are expected to rise due to population increases, economic growth and climate change. Hence, understanding the physical and spatiotemporal characteristics of risk drivers (hazard, exposure and vulnerability) is required to develop effective flood mitigation measures. Here, the long-term trend in flood vulnerability was analysed globally, calculated from the ratio of the reported flood loss or damage to the modelled flood exposure using a global river and inundation model. A previous study showed decreasing global flood vulnerability over a shorter period using different disaster data. The long-term analysis demonstrated for the first time that flood vulnerability to economic losses in upper-middle, lower-middle and low-income countries shows an inverted U-shape, as a result of the balance between economic growth and various historical socioeconomic efforts to reduce damage, leading to non-significant upward or downward trends. We also show that the flood-exposed population is affected by historical changes in population distribution, with changes in flood vulnerability of up to 48.9%. Both increasing and decreasing trends in flood vulnerability were observed in different countries, implying that population growth scenarios considering spatial distribution changes could affect flood risk projections.

Global-scale river flood vulnerability in the last 50 years

PubMed Central

Tanoue, Masahiro; Hirabayashi, Yukiko; Ikeuchi, Hiroaki

2016-01-01

The impacts of flooding are expected to rise due to population increases, economic growth and climate change. Hence, understanding the physical and spatiotemporal characteristics of risk drivers (hazard, exposure and vulnerability) is required to develop effective flood mitigation measures. Here, the long-term trend in flood vulnerability was analysed globally, calculated from the ratio of the reported flood loss or damage to the modelled flood exposure using a global river and inundation model. A previous study showed decreasing global flood vulnerability over a shorter period using different disaster data. The long-term analysis demonstrated for the first time that flood vulnerability to economic losses in upper-middle, lower-middle and low-income countries shows an inverted U-shape, as a result of the balance between economic growth and various historical socioeconomic efforts to reduce damage, leading to non-significant upward or downward trends. We also show that the flood-exposed population is affected by historical changes in population distribution, with changes in flood vulnerability of up to 48.9%. Both increasing and decreasing trends in flood vulnerability were observed in different countries, implying that population growth scenarios considering spatial distribution changes could affect flood risk projections. PMID:27782160

Contrast-enhanced ultrasound imaging of intraplaque neovascularization and its correlation to plaque echogenicity in human carotid arteries atherosclerosis.

PubMed

Cattaneo, Mattia; Staub, Daniel; Porretta, Alessandra P; Gallino, Jeanne Marie; Santini, Paolo; Limoni, Costanzo; Wyttenbach, Rolf; Gallino, Augusto

2016-11-15

Currently the most widely accepted predictor of stroke risk in patients with carotid atherosclerosis is the degree of stenoses. Plaque echogenicity on ultrasound imaging (US) and intraplaque neovascularization (IPNV) are becoming recognized as factors of plaque vulnerability. Aim of the study was to investigate the correlation between the echogenicity of the carotid atherosclerosis by standard US and the degree of IPNV by contrast enhanced US (CEUS). We recruited 45 consecutive subjects with an asymptomatic ≥50% carotid artery stenoses. Carotid plaque echogenicity at standard US was visually graded according to Gray-Weale classification (GW) and measured by the grayscale median (GSM), a semi-automated measurement performed by Adobe Photoshop©. On CEUS imaging IPNV was graded by different point scales according to the visual appearance of contrast within the plaque as follows: CEUS_A (1=absent; 2=present); CEUS_B (increasing IPNV from 1 to 3); and CEUS_C (increasing IPNV from 0 to 3). The correlation between echogenicity by GW and IPNV grading was as follows: CEUS_B (-0.130 p .423), CEUS_C (-0.108, p .509), CEUS_A (0.021, p .897). The correlation between echogenicity by GSM measurement and IPNV was as follows: using a CEUS_A (-0.125, p .444), CEUS_C (-0.021, p .897) (0.005, p .977). No correlation was found statistically significant. Our results display that there is no significant correlation between plaque echogenicity and IPNV. The small sample number and the multifaceted pathophysiology of the atherosclerotic plaque may explain the absence of statistically significantly correlation. Curtailing vulnerability explanation to either IPNV or echolucency may be misleading. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Electronic cigarettes and mental illness: Reviewing the evidence for help and harm among those with psychiatric and substance use disorders.

PubMed

Hefner, Kathryn; Valentine, Gerald; Sofuoglu, Mehmet

2017-06-01

Adults with mental illness (MI) use combustible tobacco at increased rates and have greater difficulty quitting smoking. Given the increasing popularity of electronic cigarettes (e-cigarettes), their use by those with MI has important health implications. While preliminary evidence suggests potential benefits of e-cigarette use for those with MI, well-controlled, systematic research examining appeal, correlates, and consequences of e-cigarette use in this vulnerable population is lacking. This review evaluated current knowledge of e-cigarette use and potential for help and/or harm among adults with MI. The search strategy resulted in k = 88 reports, of which k = 9 were deemed relevant. E-cigarette use is prevalent among those with MI, as is concurrent use of e-cigarettes and combustibles. E-cigarettes appeal to those with MI as a viable alternative to combustible tobacco, and their use does not appear to exacerbate nicotine addiction or psychiatric symptoms. However, the long-term impact of e-cigarette use on combustible tobacco use and other health indices is largely unknown. Rigorous research and improved knowledge regarding risks and benefits of e-cigarette use within this vulnerable population are needed to inform whether special consideration is warranted towards those with MI in developing tobacco control policies and health communications. Recommendations for future e-cigarette research include improved assessment of the following: 1) psychodiagnostic variability, 2) flavor preferences, 3) the longitudinal impact on combustible tobacco use, and 4) impact of tobacco product communications. As with combustible cigarettes, individuals with MI may display unique e-cigarette use patterns from that of the general population. (Am J Addict 2017;26:306-315). Published 2017. This article is a U.S. Government work and is in the public domain in the USA.

Computer tool to evaluate the cue reactivity of chemically dependent individuals.

PubMed

Silva, Meire Luci da; Frère, Annie France; Oliveira, Henrique Jesus Quintino de; Martucci Neto, Helio; Scardovelli, Terigi Augusto

2017-03-01

Anxiety is one of the major influences on the dropout of relapse and treatment of substance abuse treatment. Chemically dependent individuals need (CDI) to be aware of their emotional state in situations of risk during their treatment. Many patients do not agree with the diagnosis of the therapist when considering them vulnerable to environmental stimuli related to drugs. This research presents a cue reactivity detection tool based on a device acquiring physiological signals connected to personal computer. Depending on the variations of the emotional state of the drug addict, alteration of the physiological signals will be detected by the computer tool (CT) which will modify the displayed virtual sets without intervention of the therapist. Developed in 3ds Max® software, the CT is composed of scenarios and objects that are in the habit of marijuana and cocaine dependent individual's daily life. The interaction with the environment is accomplished using a Human-Computer Interface (HCI) that converts incoming physiological signals indicating anxiety state into commands that change the scenes. Anxiety was characterized by the average variability from cardiac and respiratory rate of 30 volunteers submitted stress environment situations. To evaluate the effectiveness of cue reactivity a total of 50 volunteers who were marijuana, cocaine or both dependent were accompanied. Prior to CT, the results demonstrated a poor correlation between the therapists' predictions and those of the chemically dependent individuals. After exposure to the CT, there was a significant increase of 73% in awareness of the risks of relapse. We confirmed the hypothesis that the CT, controlled only by physiological signals, increases the perception of vulnerability to risk situations of individuals with dependence on marijuana, cocaine or both. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Vulnerability and seismic damage scenarios for Barcelona (Spain) by using GIS

NASA Astrophysics Data System (ADS)

Lantada, N.; Pujades, L. G.; Barbat, A.

2003-04-01

An integrated GIS-based analysis (using ArcView GIS) is performed in order to estimate damage scenarios for VI, VII and VIII EMS-98 seismic intensities in Barcelona (Spain). The analysis of vulnerability and damage of individual buildings is performed according to a simplified method developed by Giovanazzi and Lagomarsino at the University of Genoa (Italy). An index of average vulnerability is associated to each building typology, which may be refined on the basis of behaviour modifiers. The index allows identification of an analytical relationship between seismic input (intensity) and damage, described by a binomial distribution. This methodology, which is based on the EMS-98 building typologies and preserves the compatibility with preceding methods, is applied to the two main residential building typologies of Barcelona, that is, unreinforced masonry and reinforced concrete buildings. Then, the specific residential buildings of Barcelona are classified in different groups characterized by a similar seismic behaviour. Therefore, all buildings belonging to each typology are cast in the most probable class according to vulnerability. In this way, the average vulnerability index is associated to each building typology of Barcelona and it is refined later on the basis of behaviour modifiers, linked to the number of stories, the year of construction and their state of maintenance. The ability of GIS tools to store, manage, analyse, and display the large amount of spatial and tabular data involved in this study allows to map average vulnerability indexes, and damage for the entire city. That is, vulnerability and damage scenarios. The obtained results show a high vulnerability and high expected seismic damage. For a VI degree of intensity, the maximum expected damage is in the range 15-30 % in the oldest zones of the city, the downtown, while for intensity VII it is in the range 45-60%. The developed GIS tool involves a friendly interface that allows new models and database information to be included in the same framework. As a new step to the seismic risk assessment, and in addition to the building characteristics, the destination of the building, as well as the essential buildings, and the density of population for census zones, have been included in the GIS database. Combining this information with the previous damage maps we will be able to obtain more complete damage scenarios including, deaths, injuries, and homeless.

Binational climate change vulnerability assessment of migratory birds in the Great Lakes Basins: Tools and impediments.

PubMed

Rempel, Robert S; Hornseth, Megan L

2017-01-01

Climate change is a global concern, requiring international strategies to reduce emissions, however, climate change vulnerability assessments are often local in scope with assessment areas restricted to jurisdictional boundaries. In our study we explored tools and impediments to understanding and responding to the effects of climate change on vulnerability of migratory birds from a binational perspective. We apply and assess the utility of a Climate Change Vulnerability Index on 3 focal species using distribution or niche modeling frameworks. We use the distributional forecasts to explore possible changes to jurisdictional conservation responsibilities resulting from shifting distributions for: eastern meadowlark (Sturnella magna), wood thrush (Hylocichla mustelina), and hooded warbler (Setophaga citrina). We found the Climate Change Vulnerability Index to be a well-organized approach to integrating numerous lines of evidence concerning effects of climate change, and provided transparency to the final assessment of vulnerability. Under this framework, we identified that eastern meadowlark and wood thrush are highly vulnerable to climate change, but hooded warbler is less vulnerable. Our study revealed impediments to assessing and modeling vulnerability to climate change from a binational perspective, including gaps in data or modeling for climate exposure parameters. We recommend increased cross-border collaboration to enhance the availability and resources needed to improve vulnerability assessments and development of conservation strategies. We did not find evidence to suggest major shifts in jurisdictional responsibility for the 3 focal species, but results do indicate increasing responsibility for these birds in the Canadian Provinces. These Provinces should consider conservation planning to help ensure a future supply of necessary habitat for these species.

Binational climate change vulnerability assessment of migratory birds in the Great Lakes Basins: Tools and impediments

PubMed Central

2017-01-01

Climate change is a global concern, requiring international strategies to reduce emissions, however, climate change vulnerability assessments are often local in scope with assessment areas restricted to jurisdictional boundaries. In our study we explored tools and impediments to understanding and responding to the effects of climate change on vulnerability of migratory birds from a binational perspective. We apply and assess the utility of a Climate Change Vulnerability Index on 3 focal species using distribution or niche modeling frameworks. We use the distributional forecasts to explore possible changes to jurisdictional conservation responsibilities resulting from shifting distributions for: eastern meadowlark (Sturnella magna), wood thrush (Hylocichla mustelina), and hooded warbler (Setophaga citrina). We found the Climate Change Vulnerability Index to be a well-organized approach to integrating numerous lines of evidence concerning effects of climate change, and provided transparency to the final assessment of vulnerability. Under this framework, we identified that eastern meadowlark and wood thrush are highly vulnerable to climate change, but hooded warbler is less vulnerable. Our study revealed impediments to assessing and modeling vulnerability to climate change from a binational perspective, including gaps in data or modeling for climate exposure parameters. We recommend increased cross-border collaboration to enhance the availability and resources needed to improve vulnerability assessments and development of conservation strategies. We did not find evidence to suggest major shifts in jurisdictional responsibility for the 3 focal species, but results do indicate increasing responsibility for these birds in the Canadian Provinces. These Provinces should consider conservation planning to help ensure a future supply of necessary habitat for these species. PMID:28225817

[Ecological vulnerability of coal mining area: a case study of Shengli Coalfield in Xilinguole of Inner Mongolia, China].

PubMed

Quan, Zhan-Jun; Li, Yuan; Li, Jun-Sheng; Han, Yu; Xiao, Neng-Wen; Fu, Meng-Di

2013-06-01

In this paper, an ecological vulnerability evaluation index system for the Shengli Coalfield in Xilinguole of Inner Mongolia was established, which included 16 factors in ecological sensitivity, natural and social pressure, and ecological recovery capacity, respectively. Based on the expert scoring method and analytic hierarchy process (AHP), an ecological vulnerability model was built for the calculation of the regional ecological vulnerability by means of RS and GIS spatial analysis. An analysis of the relationships between land use and ecological vulnerability was also made, and the results were tested by spatial auto-correlation analysis. Overall, the ecological vulnerability of the study area was at medium-high level. The exploitation of four opencast areas in the Coalfield caused a significant increase of ecological vulnerability. Moreover, due to the effects of mine drained water and human activities, the 300 -2000 m around the opencast areas was turning into higher ecologically fragile area. With further exploitation, the whole Coalfield was evolved into moderate and heavy ecological vulnerability area, and the coal resources mining was a key factor in this process. The cluster analysis showed that the spatial distribution of the ecological vulnerability in the study area had reasonable clustering characteristics. To decrease the population density, control the grazing capacity of grassland, and regulate the ratios of construction land and cultivated land could be the optimal ways for resolving the natural and social pressure, and to increase the investment and improve the vegetation recovery coefficient could be the fundamental measures for decreasing the ecological vulnerability of the study area.

The role of plastic β-hairpin and weak hydrophobic core in the stability and unfolding of a full sequence design protein

NASA Astrophysics Data System (ADS)

Lei, Hongxing; Duan, Yong

2004-12-01

In this study, the thermal stability of a designed α/β protein FSD (full sequence design) was studied by explicit solvent simulations at three moderate temperatures, 273 K, 300 K, and 330 K. The average properties of the ten trajectories at each temperature were analyzed. The thermal unfolding, as judged by backbone root-mean-square deviation and percentage of native contacts, was displayed with increased sampling outside of the native basin as the temperature was raised. The positional fluctuation of the hairpin residues was significantly higher than that of the helix residues at all three temperatures. The hairpin segment displayed certain plasticity even at 273 K. Apart from the terminal residues, the highest fluctuation was shown in the turn residues 7-9. Secondary structure analysis manifested the structural heterogeneity of the hairpin segment. It was also revealed by the simulation that the hydrophobic core was vulnerable to thermal denaturation. Consistent with the experiment, the I7Y mutation in the double mutant FSD-EY (FSD with mutations Q1E and I7Y) dramatically increased the protein stability in the simulation, suggesting that the plasticity of the hairpin can be partially compensated by a stronger hydrophobic core. As for the unfolding pathway, the breathing of the hydrophobic core and the separation of the two secondary structure elements (α helix and β hairpin) was the initiation step of the unfolding. The loss of global contacts from the separation further destabilized the hairpin structure and also led to the unwinding of the helix.

The role of plastic beta-hairpin and weak hydrophobic core in the stability and unfolding of a full sequence design protein.

PubMed

Lei, Hongxing; Duan, Yong

2004-12-15

In this study, the thermal stability of a designed alpha/beta protein FSD (full sequence design) was studied by explicit solvent simulations at three moderate temperatures, 273 K, 300 K, and 330 K. The average properties of the ten trajectories at each temperature were analyzed. The thermal unfolding, as judged by backbone root-mean-square deviation and percentage of native contacts, was displayed with increased sampling outside of the native basin as the temperature was raised. The positional fluctuation of the hairpin residues was significantly higher than that of the helix residues at all three temperatures. The hairpin segment displayed certain plasticity even at 273 K. Apart from the terminal residues, the highest fluctuation was shown in the turn residues 7-9. Secondary structure analysis manifested the structural heterogeneity of the hairpin segment. It was also revealed by the simulation that the hydrophobic core was vulnerable to thermal denaturation. Consistent with the experiment, the I7Y mutation in the double mutant FSD-EY (FSD with mutations Q1E and I7Y) dramatically increased the protein stability in the simulation, suggesting that the plasticity of the hairpin can be partially compensated by a stronger hydrophobic core. As for the unfolding pathway, the breathing of the hydrophobic core and the separation of the two secondary structure elements (alpha helix and beta hairpin) was the initiation step of the unfolding. The loss of global contacts from the separation further destabilized the hairpin structure and also led to the unwinding of the helix. (c) 2004 American Institute of Physics

[Is cocoa a psychotropic drug? Psychopathologic study of a population of subjects self-identified as chocolate addicts].

PubMed

Dallard, I; Cathebras, P; Sauron, C; Massoubre, C

2001-01-01

The aim of this work was to search for eating disorders, DSM III-R Axis I mental disorders, personality disorders, and addictive behavior, in self-labeled "chocolate addicts". Subjects were recruited through advertisements placed in a university and a hospital. Fifteen subjects were included, 3 men and 12 women aged between 18 and 49. Most of them were not overweight, although 7 thought they had a weight problem. They consumed an average of 50 g per day of pure cacao and, for 13 subjects, this consumption was lasting since childhood or adolescence. The psychological effects of chocolate, as indicated by the subjects, consisted in feelings of increased energy or increased concentration ability, and in an anxiolytic effect during stress. Seven subjects described minor withdrawal symptoms. None of the subjects reached the thresholds for eating disorders on the EAT and BULIT scales. The structured interview (MINI) identified an important ratio of subjects with a history of major depressive episode (13/15), and one woman was currently experiencing a major depressive episode. Four people suffered, or had suffered from anxiety disorders. Although only one subject satisfied all criteria for a personality disorder on the DIP-Q, seven displayed some pathological personality features. The self-labeled "chocoholics" do not seem to suffer from eating disorders, but may represent a population of psychologically vulnerable and depression--or anxiety--prone people. They seem to use chocolate as a light psychotropic drug able to relieve some of their distress. The amount of cacao consumed, although very chronically, remains moderate, and they rarely display other addictive behaviors.

Forecasting Urban Forest Ecosystem Structure, Function, and Vulnerability

NASA Astrophysics Data System (ADS)

Steenberg, James W. N.; Millward, Andrew A.; Nowak, David J.; Robinson, Pamela J.; Ellis, Alexis

2017-03-01

The benefits derived from urban forest ecosystems are garnering increasing attention in ecological research and municipal planning. However, because of their location in heterogeneous and highly-altered urban landscapes, urban forests are vulnerable and commonly suffer disproportionate and varying levels of stress and disturbance. The objective of this study is to assess and analyze the spatial and temporal changes, and potential vulnerability, of the urban forest resource in Toronto, Canada. This research was conducted using a spatially-explicit, indicator-based assessment of vulnerability and i-Tree Forecast modeling of temporal changes in forest structure and function. Nine scenarios were simulated for 45 years and model output was analyzed at the ecosystem and municipal scale. Substantial mismatches in ecological processes between spatial scales were found, which can translate into unanticipated loss of function and social inequities if not accounted for in planning and management. At the municipal scale, the effects of Asian longhorned beetle and ice storm disturbance were far less influential on structure and function than changes in management actions. The strategic goals of removing invasive species and increasing tree planting resulted in a decline in carbon storage and leaf biomass. Introducing vulnerability parameters in the modeling increased the spatial heterogeneity in structure and function while expanding the disparities of resident access to ecosystem services. There was often a variable and uncertain relationship between vulnerability and ecosystem structure and function. Vulnerability assessment and analysis can provide strategic planning initiatives with valuable insight into the processes of structural and functional change resulting from management intervention.

Forecasting Urban Forest Ecosystem Structure, Function, and Vulnerability.

PubMed

Steenberg, James W N; Millward, Andrew A; Nowak, David J; Robinson, Pamela J; Ellis, Alexis

2017-03-01

The benefits derived from urban forest ecosystems are garnering increasing attention in ecological research and municipal planning. However, because of their location in heterogeneous and highly-altered urban landscapes, urban forests are vulnerable and commonly suffer disproportionate and varying levels of stress and disturbance. The objective of this study is to assess and analyze the spatial and temporal changes, and potential vulnerability, of the urban forest resource in Toronto, Canada. This research was conducted using a spatially-explicit, indicator-based assessment of vulnerability and i-Tree Forecast modeling of temporal changes in forest structure and function. Nine scenarios were simulated for 45 years and model output was analyzed at the ecosystem and municipal scale. Substantial mismatches in ecological processes between spatial scales were found, which can translate into unanticipated loss of function and social inequities if not accounted for in planning and management. At the municipal scale, the effects of Asian longhorned beetle and ice storm disturbance were far less influential on structure and function than changes in management actions. The strategic goals of removing invasive species and increasing tree planting resulted in a decline in carbon storage and leaf biomass. Introducing vulnerability parameters in the modeling increased the spatial heterogeneity in structure and function while expanding the disparities of resident access to ecosystem services. There was often a variable and uncertain relationship between vulnerability and ecosystem structure and function. Vulnerability assessment and analysis can provide strategic planning initiatives with valuable insight into the processes of structural and functional change resulting from management intervention.

Vulnerability of social-ecological system to climate change in Mongolia

NASA Astrophysics Data System (ADS)

Kakinuma, K.; Yanagawa, A.; Sasaki, T.; Kanae, S.

2017-12-01

Coping with future climate changes are one of the most important issues in the world. IPCC (2014) suggested that vulnerability and exposure of social-ecological systems to extreme climatic events (hazard) determine the impact of climate changes. Although the schematic framework is widely accepted, there are high uncertainty of vulnerability of social and ecological systems and it makes difficult to examine it in empirical researches. Our objective is to assess the climate change impact on the social-ecological system in Mongolia. We review researches about trends of climate (Hazard), vegetation, pastoral mobility (Vulnerability) and livestock distribution (Exposure) across Mongolia Climate trends are critical for last several decades and thus hazard may be increasing in Mongolia. Temperature is increasing with high confidence in all regions. Precipitation are slightly decreasing with medium confidence across the country, especially in northern and central regions. Exposure would also be increasing especially in northern, central and western regions, because livestock population are concentrating these regions after 1990. Generally, less productive ecosystems (e.g. few plant productivity and less species richness) are vulnerable to extreme climatic events such as drought. In that sense, southern region may be more vulnerable to climate changes than other regions. However, if we focus on pastoral mobility forms for drought, we get contractive conclusions. Pastoralists in southern region keep mobility to variable and scarce vegetation while pastoralists in northern region less mobile because of stable and much vegetation. Exclusive managements in northern region is able to maximized the number of livestock only under stable precipitation regimes. But at the same time, it is difficult to escape from hazardous areas when it is drought. Thus, in term of rangeland management, northern region would be more vulnerable to increase of drought intensity. Although northern and central regions have high ecological productivity, they have high livestock density (high exposure) and their rangeland management don't adapt well to drought (high vulnerability). Therefore, we suggested that these regions have to prepare to climate changes for sustainable rangeland managements.

V-DRASTIC: Using visualization to engage policymakers in groundwater vulnerability assessment

NASA Astrophysics Data System (ADS)

Bojórquez-Tapia, Luis A.; Cruz-Bello, Gustavo M.; Luna-González, Laura; Juárez, Lourdes; Ortiz-Pérez, Mario A.

2009-06-01

SummaryGroundwater vulnerability mapping is increasingly being used to design aquifer protection and management strategies. This paper presents a dynamic visualization method to groundwater vulnerability mapping. This method—called V-DRASTIC—extends the capacities of DRASTIC, an overlay/index technique that has been applied worldwide to evaluate the condition of hydrogeological factors and determine groundwater vulnerability at regional scales. V-DRASTIC is based upon psychophysics' principles (a theory that describes the people's response to a stimulus) to generate alternative groundwater vulnerability categorization schemes. These are used as inputs in a fuzzy pattern recognition procedure to enable planners, decision makers and stakeholders identify which scheme conveys meaningful information regarding groundwater vulnerability across a territory. V-DRASTIC was applied in the groundwater vulnerability assessment of two urban watersheds in Mexico.

Declining vulnerability to river floods and the global benefits of adaptation

PubMed Central

Jongman, Brenden; Winsemius, Hessel C.; Aerts, Jeroen C. J. H.; Coughlan de Perez, Erin; van Aalst, Maarten K.; Kron, Wolfgang; Ward, Philip J.

2015-01-01

The global impacts of river floods are substantial and rising. Effective adaptation to the increasing risks requires an in-depth understanding of the physical and socioeconomic drivers of risk. Whereas the modeling of flood hazard and exposure has improved greatly, compelling evidence on spatiotemporal patterns in vulnerability of societies around the world is still lacking. Due to this knowledge gap, the effects of vulnerability on global flood risk are not fully understood, and future projections of fatalities and losses available today are based on simplistic assumptions or do not include vulnerability. We show for the first time (to our knowledge) that trends and fluctuations in vulnerability to river floods around the world can be estimated by dynamic high-resolution modeling of flood hazard and exposure. We find that rising per-capita income coincided with a global decline in vulnerability between 1980 and 2010, which is reflected in decreasing mortality and losses as a share of the people and gross domestic product exposed to inundation. The results also demonstrate that vulnerability levels in low- and high-income countries have been converging, due to a relatively strong trend of vulnerability reduction in developing countries. Finally, we present projections of flood losses and fatalities under 100 individual scenario and model combinations, and three possible global vulnerability scenarios. The projections emphasize that materialized flood risk largely results from human behavior and that future risk increases can be largely contained using effective disaster risk reduction strategies. PMID:25902499

Physical assessment of coastal vulnerability under enhanced land subsidence in Semarang, Indonesia, using multi-sensor satellite data

NASA Astrophysics Data System (ADS)

Husnayaen; Rimba, A. Besse; Osawa, Takahiro; Parwata, I. Nyoman Sudi; As-syakur, Abd. Rahman; Kasim, Faizal; Astarini, Ida Ayu

2018-04-01

Research has been conducted in Semarang, Indonesia, to assess coastal vulnerability under enhanced land subsidence using multi-sensor satellite data, including the Advanced Land Observing Satellite (ALOS) Phased Array type L-band SAR (PALSAR), Landsat TM, IKONOS, and TOPEX/Poseidon. A coastal vulnerability index (CVI) was constructed to estimate the level of vulnerability of a coastline approximately 48.68 km in length using seven physical variables, namely, land subsidence, relative sea level change, coastal geomorphology, coastal slope, shoreline change, mean tidal range, and significant wave height. A comparison was also performed between a CVI calculated using seven parameters and a CVI using six parameters, the latter of which excludes the land subsidence parameter, to determine the effects of land subsidence during the coastal vulnerability assessment. This study showed that the accuracy of coastal vulnerability was increased 40% by adding the land subsidence factor (i.e., CVI 6 parameters = 53%, CVI 7 parameters = 93%). Moreover, Kappa coefficient indicated very good agreement (0.90) for CVI 7 parameters and fair agreement (0.3) for CVI 6 parameters. The results indicate that the area of very high vulnerability increased by 7% when land subsidence was added. Hence, using the CVI calculation including land subsidence parameters, the very high vulnerability area is determined to be 20% of the total coastline or 9.7 km of the total 48.7 km of coastline. This study proved that land subsidence has significant influence on coastal vulnerability in Semarang.

Declining vulnerability to river floods and the global benefits of adaptation.

PubMed

Jongman, Brenden; Winsemius, Hessel C; Aerts, Jeroen C J H; Coughlan de Perez, Erin; van Aalst, Maarten K; Kron, Wolfgang; Ward, Philip J

2015-05-05

The global impacts of river floods are substantial and rising. Effective adaptation to the increasing risks requires an in-depth understanding of the physical and socioeconomic drivers of risk. Whereas the modeling of flood hazard and exposure has improved greatly, compelling evidence on spatiotemporal patterns in vulnerability of societies around the world is still lacking. Due to this knowledge gap, the effects of vulnerability on global flood risk are not fully understood, and future projections of fatalities and losses available today are based on simplistic assumptions or do not include vulnerability. We show for the first time (to our knowledge) that trends and fluctuations in vulnerability to river floods around the world can be estimated by dynamic high-resolution modeling of flood hazard and exposure. We find that rising per-capita income coincided with a global decline in vulnerability between 1980 and 2010, which is reflected in decreasing mortality and losses as a share of the people and gross domestic product exposed to inundation. The results also demonstrate that vulnerability levels in low- and high-income countries have been converging, due to a relatively strong trend of vulnerability reduction in developing countries. Finally, we present projections of flood losses and fatalities under 100 individual scenario and model combinations, and three possible global vulnerability scenarios. The projections emphasize that materialized flood risk largely results from human behavior and that future risk increases can be largely contained using effective disaster risk reduction strategies.

The drought risk of maize in the farming-pastoral ecotone in Northern China based on physical vulnerability assessment

NASA Astrophysics Data System (ADS)

Wang, Zhiqiang; Jiang, Jingyi; Ma, Qing

2016-12-01

Climate change is affecting every aspect of human activities, especially the agriculture. In China, extreme drought events caused by climate change have posed a great threat to food safety. In this work we aimed to study the drought risk of maize in the farming-pastoral ecotone in Northern China based on physical vulnerability assessment. The physical vulnerability curve was constructed from the relationship between drought hazard intensity index and yield loss rate. The risk assessment of agricultural drought was conducted from the drought hazard intensity index and physical vulnerability curve. The probability distribution of drought hazard intensity index decreased from south-west to north-east and increased from south-east to north-west along the rainfall isoline. The physical vulnerability curve had a reduction effect in three parts of the farming-pastoral ecotone in Northern China, which helped to reduce drought hazard vulnerability on spring maize. The risk of yield loss ratio calculated based on physical vulnerability curve was lower compared with the drought hazard intensity index, which suggested that the capacity of spring maize to resist and adapt to drought is increasing. In conclusion, the farming-pastoral ecotone in Northern China is greatly sensitive to climate change and has a high probability of severe drought hazard. Risk assessment of physical vulnerability can help better understand the physical vulnerability to agricultural drought and can also promote measurements to adapt to climate change.

Differential Outcomes of Adult Education on Adult Learners' Increase in Social Inclusion

ERIC Educational Resources Information Center

de Greef, Maurice; Verté, Dominique; Segers, Mien

2015-01-01

To date a significant share of the European population can be considered at risk of social exclusion. It has been argued that adult education programmes are a powerful tool to support vulnerable adults increasing their social inclusion. This study aims to answer the question if and which subgroups of vulnerable adults experience an increase in…

Imprinting center analysis in Prader-Willi and Angelman syndrome patients with typical and atypical phenotypes.

PubMed

Camprubí, Cristina; Coll, Maria Dolors; Villatoro, Sergi; Gabau, Elisabeth; Kamli, Amine; Martínez, Maria Jesus; Poyatos, David; Guitart, Miriam

2007-01-01

Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are genetic disorders caused by a deficiency of imprinted gene expression from the paternal or maternal chromosome 15, respectively. This deficiency is due to the deletion of the 15q11-q13 region, parental uniparental disomy of the chromosome 15, or imprinting defect (ID). Mutation of the UBE3A gene causes approximately 10% of AS cases. In this present study, we describe the molecular analysis and phenotypes of two PWS patients and four AS patients with ID. One of the PWS patients has a non-familial imprinting center (IC) deletion and displayed a severe phenotype with an atypical PWS appearance, hyperactivity and psychiatric vulnerability. The other PWS and AS patients did not present genetic abnormalities in the IC, suggesting an epimutation as the genetic cause. The methylation pattern of two AS patients showed a faint maternal band corresponding to a mosaic ID. One of these mosaic patients displayed a mild AS phenotype while the other displayed a PWS-like phenotype.

Do Clinical Standards for Diabetes Care Address Excess Risk for Hypoglycemia in Vulnerable Patients? A Systematic Review

PubMed Central

Berkowitz, Seth A; Aragon, Katherine; Hines, Jonas; Seligman, Hilary; Lee, Sei; Sarkar, Urmimala

2013-01-01

Objective To determine whether diabetes clinical standards consider increased hypoglycemia risk in vulnerable patients. Data Sources MEDLINE, the National Guidelines Clearinghouse, the National Quality Measures Clearinghouse, and supplemental sources. Study Design Systematic review of clinical standards (guidelines, quality metrics, or pay-for-performance programs) for glycemic control in adult diabetes patients. The primary outcome was discussion of increased risk for hypoglycemia in vulnerable populations. Data Collection/Extraction Methods Manuscripts identified were abstracted by two independent reviewers using prespecified inclusion/exclusion criteria and a standardized abstraction form. Principal Findings We screened 1,166 titles, and reviewed 220 manuscripts in full text. Forty-four guidelines, 17 quality metrics, and 8 pay-for-performance programs were included. Five (11 percent) guidelines and no quality metrics or pay-for-performance programs met the primary outcome. Conclusions Clinical standards do not substantively incorporate evidence about increased risk for hypoglycemia in vulnerable populations. PMID:23445498

Do clinical standards for diabetes care address excess risk for hypoglycemia in vulnerable patients? A systematic review.

PubMed

Berkowitz, Seth A; Aragon, Katherine; Hines, Jonas; Seligman, Hilary; Lee, Sei; Sarkar, Urmimala

2013-08-01

To determine whether diabetes clinical standards consider increased hypoglycemia risk in vulnerable patients. MEDLINE, the National Guidelines Clearinghouse, the National Quality Measures Clearinghouse, and supplemental sources. Systematic review of clinical standards (guidelines, quality metrics, or pay-for-performance programs) for glycemic control in adult diabetes patients. The primary outcome was discussion of increased risk for hypoglycemia in vulnerable populations. Manuscripts identified were abstracted by two independent reviewers using prespecified inclusion/exclusion criteria and a standardized abstraction form. We screened 1,166 titles, and reviewed 220 manuscripts in full text. Forty-four guidelines, 17 quality metrics, and 8 pay-for-performance programs were included. Five (11 percent) guidelines and no quality metrics or pay-for-performance programs met the primary outcome. Clinical standards do not substantively incorporate evidence about increased risk for hypoglycemia in vulnerable populations. © Health Research and Educational Trust.

Sustained Perceptual Deficits from Transient Sensory Deprivation

PubMed Central

Sanes, Dan H.

2015-01-01

Sensory pathways display heightened plasticity during development, yet the perceptual consequences of early experience are generally assessed in adulthood. This approach does not allow one to identify transient perceptual changes that may be linked to the central plasticity observed in juvenile animals. Here, we determined whether a brief period of bilateral auditory deprivation affects sound perception in developing and adult gerbils. Animals were reared with bilateral earplugs, either from postnatal day 11 (P11) to postnatal day 23 (P23) (a manipulation previously found to disrupt gerbil cortical properties), or from P23-P35. Fifteen days after earplug removal and restoration of normal thresholds, animals were tested on their ability to detect the presence of amplitude modulation (AM), a temporal cue that supports vocal communication. Animals reared with earplugs from P11-P23 displayed elevated AM detection thresholds, compared with age-matched controls. In contrast, an identical period of earplug rearing at a later age (P23-P35) did not impair auditory perception. Although the AM thresholds of earplug-reared juveniles improved during a week of repeated testing, a subset of juveniles continued to display a perceptual deficit. Furthermore, although the perceptual deficits induced by transient earplug rearing had resolved for most animals by adulthood, a subset of adults displayed impaired performance. Control experiments indicated that earplugging did not disrupt the integrity of the auditory periphery. Together, our results suggest that P11-P23 encompasses a critical period during which sensory deprivation disrupts central mechanisms that support auditory perceptual skills. SIGNIFICANCE STATEMENT Sensory systems are particularly malleable during development. This heightened degree of plasticity is beneficial because it enables the acquisition of complex skills, such as music or language. However, this plasticity comes with a cost: nervous system development displays an increased vulnerability to the sensory environment. Here, we identify a precise developmental window during which mild hearing loss affects the maturation of an auditory perceptual cue that is known to support animal communication, including human speech. Furthermore, animals reared with transient hearing loss display deficits in perceptual learning. Our results suggest that speech and language delays associated with transient or permanent childhood hearing loss may be accounted for, in part, by deficits in central auditory processing mechanisms. PMID:26224865

Are perfectionistic concerns an antecedent of or a consequence of binge eating, or both? A short-term four-wave longitudinal study of undergraduate women.

PubMed

Smith, Martin M; Sherry, Simon B; Gautreau, Chantal M; Stewart, Sherry H; Saklofske, Donald H; Mushquash, Aislin R

2017-08-01

The perfectionism model of binge eating (PMOBE) posits perfectionistic concerns are a vulnerability factor for binge eating. And evidence indicates perfectionistic concerns and binge eating correlate positively. However, the direction of this relationship is seldom studied. Accordingly, it is unclear whether perfectionistic concerns represent an antecedent of binge eating (a vulnerability effect with perfectionistic concerns predicting increases in binge eating), a consequence of binge eating (a complication effect with binge eating predicting increases in perfectionistic concerns), or both (reciprocal relations with perfectionistic concerns predicting increases in binge eating and vice versa). To address these questions, we studied 200 undergraduate women using a 4-week, 4-wave cross-lagged longitudinal design. Consistent with the PMOBE, perfectionistic concerns predicted increased binge eating (vulnerability effect). But, binge eating did not predict increased perfectionistic concerns (complication effect). Findings support the long-held theory that perfectionistic concerns are part of the premorbid personality of women vulnerable to binge eating. Copyright © 2017 Elsevier Ltd. All rights reserved.

Xylem vulnerability to cavitation can be accurately characterised in species with long vessels using a centrifuge method.

PubMed

Tobin, M F; Pratt, R B; Jacobsen, A L; De Guzman, M E

2013-05-01

Vulnerability to cavitation curves describe the decrease in xylem hydraulic conductivity as xylem pressure declines. Several techniques for constructing vulnerability curves use centrifugal force to induce negative xylem pressure in stem or root segments. Centrifuge vulnerability curves constructed for long-vesselled species have been hypothesised to overestimate xylem vulnerability to cavitation due to increased vulnerability of vessels cut open at stem ends that extend to the middle or entirely through segments. We tested two key predictions of this hypothesis: (i) centrifugation induces greater embolism than dehydration in long-vesselled species, and (ii) the proportion of open vessels changes centrifuge vulnerability curves. Centrifuge and dehydration vulnerability curves were compared for a long- and short-vesselled species. The effect of open vessels was tested in four species by comparing centrifuge vulnerability curves for stems of two lengths. Centrifuge and dehydration vulnerability curves agreed well for the long- and short-vesselled species. Centrifuge vulnerability curves constructed using two stem lengths were similar. Also, the distribution of embolism along the length of centrifuged stems matched the theoretical pressure profile induced by centrifugation. We conclude that vulnerability to cavitation can be accurately characterised with vulnerability curves constructed using a centrifuge technique, even in long-vesselled species. © 2012 German Botanical Society and The Royal Botanical Society of the Netherlands.

Vulnerability related to oral health in early childhood: a concept analysis.

PubMed

Mattheus, Deborah J

2010-09-01

This article is a report of the analysis of the concept of vulnerability and its relationship to oral health in early childhood. Poor oral health is a continued problem for children worldwide. Vulnerability increases the probability of poor oral health outcomes. The lack of clarity of the concept of vulnerability creates difficulty in understanding this multi-factoral condition. Data source included 34 articles covering the period 2000-2009 from a variety of disciplines, including nursing, dentistry, medicine and public health. The concept analysis was conducted using Rodgers' evolutionary method. The literature was analysed and a social ecology model was used to frame the discussion, recognizing family and community influences on children's oral health. The context of oral health in early childhood contributes to the changes in the concept vulnerability. The attributes are closely related to family and community factors and identified as limited parental income, parental education, community-based services and fluoride; and exposure to poor parental habits, parental neglect and harmful toxins. The primary antecedent is identified as a form of limited protection from exposure to various circumstances. Children with limited protection have increased vulnerability and greater probability of poor health outcomes. Nurses who understand the concept of vulnerability related to oral health and can identify factors that create protection and are capable of decreasing vulnerability through parent education, community awareness and policy changes that support children and families.

What predicts depression in cardiac patients: sociodemographic factors, disease severity or theoretical vulnerabilities?

PubMed

Doyle, F; McGee, H M; Conroy, R M; Delaney, M

2011-05-01

Depression is associated with increased cardiovascular risk in acute coronary syndrome (ACS) patients, but some argue that elevated depression is actually a marker of cardiovascular disease severity. Therefore, disease indices should better predict depression than established theoretical causes of depression (interpersonal life events, reinforcing events, cognitive distortions, type D personality). However, little theory-based research has been conducted in this area. In a cross-sectional design, ACS patients (n = 336) completed questionnaires assessing depression and psychosocial vulnerabilities. Nested logistic regression assessed the relative contribution of demographic or vulnerability factors, or disease indices or vulnerabilities to depression. In multivariate analysis, all vulnerabilities were independent significant predictors of depression (scoring above threshold on any scale, 48%). Demographic variables accounted for <1% of the variance of depression status, with vulnerabilities accounting for significantly more (pseudo R² = 0.16, χ²(change) = 150.9, df = 4, p < 0.001). Disease indices accounted for 7% of the variance in depression (pseudo R² = 0.07, χ² = 137.9, p < 0.001). However, adding the vulnerabilities increased the overall variance explained to 22% (pseudo R² = 0.22, χ² = 58.6, df = 4, p < 0.001). Theoretical vulnerabilities predicted depression status better than did either demographic or disease indices. The presence of these proximal causes of depression suggests that depression in ACS patients is not simply a result of cardiovascular disease severity.

Diel vertical movements, and effects of infection by the cestode Schistocephalus solidus on daytime proximity of three-spined sticklebacks Gasterosteus aculeatus to the surface of a large Alaskan lake.

PubMed

Quinn, T P; Kendall, N W; Rich, H B; Chasco, B E

2012-01-01

We conducted a field study in Iliamna Lake, Alaska, to test the hypothesis that proximity of three-spined sticklebacks Gasterosteus aculeatus to the lake's surface during the daytime varies with macroparasitic cestode parasite Schistocephalus solidus infection in a manner consistent with enhanced vulnerability to avian predators. Extensive sampling in the lake and likelihood-based modeling revealed that sticklebacks displayed a diel vertical migration, being closer to the surface at night than during the evening and early morning. Additional sampling, also coupled with a likelihood-based modeling approach, showed that fish caught at the surface of the lake during the day were more often parasitized (76 vs. 65%), more heavily parasitized (26.8 vs. 22.7% of their body mass), and had larger individual parasites (0.24 vs. 0.20 g) than those caught at night. Parasite infection was related, non-linearly, to fish size, which also differed between day and night sampling at the surface. We performed statistical competitions among nested hierarchies of models that accounted for this effect of length. The most likely models indicated that fish captured during the day had greater parasite prevalence, higher parasite burdens, and larger parasites than did fish captured at night. Proximity to the surface during the day in this very clear lake would likely increase the vulnerability of sticklebacks to predation from birds, enabling completion of the parasite's lifecycle.

Long-term archives reveal shifting extinction selectivity in China's postglacial mammal fauna

PubMed Central

Crees, Jennifer J.; Li, Zhipeng; Bielby, Jon; Yuan, Jing

2017-01-01

Ecosystems have been modified by human activities for millennia, and insights about ecology and extinction risk based only on recent data are likely to be both incomplete and biased. We synthesize multiple long-term archives (over 250 archaeological and palaeontological sites dating from the early Holocene to the Ming Dynasty and over 4400 historical records) to reconstruct the spatio-temporal dynamics of Holocene–modern range change across China, a megadiverse country experiencing extensive current-day biodiversity loss, for 34 mammal species over three successive postglacial time intervals. Our combined zooarchaeological, palaeontological, historical and current-day datasets reveal that both phylogenetic and spatial patterns of extinction selectivity have varied through time in China, probably in response both to cumulative anthropogenic impacts (an ‘extinction filter’ associated with vulnerable species and accessible landscapes being affected earlier by human activities) and also to quantitative and qualitative changes in regional pressures. China has experienced few postglacial global species-level mammal extinctions, and most species retain over 50% of their maximum estimated Holocene range despite millennia of increasing regional human pressures, suggesting that the potential still exists for successful species conservation and ecosystem restoration. Data from long-term archives also demonstrate that herbivores have experienced more historical extinctions in China, and carnivores have until recently displayed greater resilience. Accurate assessment of patterns of biodiversity loss and the likely predictive power of current-day correlates of faunal vulnerability and resilience is dependent upon novel perspectives provided by long-term archives. PMID:29167363

Vesicular Monoamine Transporter 2 (VMAT2) Level Regulates MPTP Vulnerability and Clearance of Excess Dopamine in Mouse Striatal Terminals.

PubMed

Lohr, Kelly M; Chen, Merry; Hoffman, Carlie A; McDaniel, Miranda J; Stout, Kristen A; Dunn, Amy R; Wang, Minzheng; Bernstein, Alison I; Miller, Gary W

2016-09-01

The vesicular monoamine transporter 2 (VMAT2) packages neurotransmitters for release during neurotransmission and sequesters toxicants into vesicles to prevent neuronal damage. In mice, low VMAT2 levels causes catecholaminergic cell loss and behaviors resembling Parkinson's disease, while high levels of VMAT2 increase dopamine release and protect against dopaminergic toxicants. However, comparisons across these VMAT2 mouse genotypes were impossible due to the differing genetic background strains of the animals. Following back-crossing to a C57BL/6 line, we confirmed that mice with approximately 95% lower VMAT2 levels compared with wild-type (VMAT2-LO) display significantly reduced vesicular uptake, progressive dopaminergic terminal loss with aging, and exacerbated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity. Conversely, VMAT2-overexpressing mice (VMAT2-HI) are protected from the loss of striatal terminals following MPTP treatment. We also provide evidence that enhanced vesicular filling in the VMAT2-HI mice modifies the handling of newly synthesized dopamine, indicated by changes in indirect measures of extracellular dopamine clearance. These results confirm the role of VMAT2 in the protection of vulnerable nigrostriatal dopamine neurons and may also provide new insight into the side effects of L-DOPA treatments in Parkinson's disease. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Positive affect protects against deficient safety learning during extinction of fear of movement-related pain in healthy individuals scoring relatively high on trait anxiety.

PubMed

Meulders, Ann; Meulders, Michel; Vlaeyen, Johan W S

2014-06-01

From a treatment perspective, it is highly relevant to pinpoint individual vulnerability factors for resistance to exposure treatment in highly fearful chronic pain patients. Previous fear conditioning research showed that healthy individuals scoring relatively high on trait anxiety display sustained fear to safety cues during extinction. In the context of fear of movement-related pain, this intriguing question has been largely neglected so far. Even more importantly, positive psychological traits such as trait positive affect may function as protective factors against the spreading of fear to safe movements and improve exposure treatment outcomes. In this study, healthy participants completed a trait anxiety and trait positive affect questionnaire and underwent acquisition and extinction of fear of movement-related pain using an experimental voluntary movement paradigm. During acquisition, one movement (CS+) was paired with a painful stimulus and another movement was not (CS-). During extinction, the CS+ was no longer reinforced. Results show failure of fear inhibition to the CS- during extinction in healthy individuals scoring relatively high on trait anxiety or relatively low on positive affect. These findings seem to suggest that safety learning is more vulnerable in healthy people with a high anxious disposition and/or relatively lower levels of positive affect. In addition, this is the first study to show that the negative impact of high trait anxiety on fear inhibition to safety cues during extinction can be countered by high levels of positive affect. These findings may have important clinical implications. Both low positive affect and high trait anxiety are associated with impaired fear inhibition to nonpainful movements during fear extinction. Interestingly, high levels of positive affect buffer against the negative impact of trait anxiety. Increasing positive affect during exposure may counter the effects of trait vulnerabilities and improve treatment outcomes. Copyright © 2014 American Pain Society. Published by Elsevier Inc. All rights reserved.

The representation of vulnerable populations in quality improvement studies.

PubMed

Rolnitsky, Asaph; Kirtsman, Maksim; Goldberg, Hanna R; Dunn, Michael; Bell, Chaim M

2018-05-01

A mapping review to quantify representation of vulnerable populations, who suffer from disparity and often inequitable healthcare, in quality improvement (QI) research. Studies published in 2004-2014 inclusive from Medline, Embase and Cochrane databases for English language research with the terms 'quality improvement' or 'quality control' or 'QI' and 'plan-do-study-act' or 'PDSA' in the years 2004-2014 inclusively. Published clinical research that was a QI-themed, as identified by its declared search terms, MESH terms, abstract or title. Three reviewers identified the eligible studies independently. Excluded were publications that were not trials, evaluations or analyses. Of 2039 results, 1660 were eligible for inclusion. There were 586 (33.5%) publications that targeted a specific vulnerable population: children (184, 10.54%), mental health patients (125, 7.16%), the elderly (100, 5.73%), women (57, 3.27%), the poor (30, 1.72%), rural residents (29, 1.66%), visible minorities (27, 1.55%), the terminally ill (17, 0.97%), adolescents (16, 0.92%) and prisoners (1 study). Seventy-four articles targeted two or more vulnerable populations, and 11 targeted three population categories. On average, there were 158 QI research studies published per year, increasing from 69 in 2004 to 396 in 2014 (R2 = 0.7, P < 0.001). The relative representation of vulnerable populations had a mean of 33.58% and was stable over the time period (standard deviation (SD) = 5.9%, R2 = 0.001). Seven countries contributed to over 85% of the publications targeting vulnerable populations, with the USA contributing 62% of the studies. Over 11 years, there has been a marked increase in QI publications. Roughly one-third of all published QI research is on vulnerable populations, a stable proportion over time. Nevertheless, some vulnerable populations are under-represented. Increased education, resources and attention are encouraged to improve the health of vulnerable populations through focused QI initiatives.

I Can't Take My Eyes Off of You: Attentional Allocation to Infant, Child, Adolescent and Adult Faces in Mothers and Non-Mothers

PubMed Central

Thompson-Booth, Chloe; Viding, Essi; Mayes, Linda C.; Rutherford, Helena J. V.; Hodsoll, Sara; McCrory, Eamon

2014-01-01

It has been reported previously that infant faces elicit enhanced attentional allocation compared to adult faces in adult women, particularly when these faces are emotional and when the participants are mothers, as compared to non-mothers [1]. However, it remains unclear whether this increased salience of infant faces as compared to adult faces extends to children older than infant age, or whether infant faces have a unique capacity to elicit preferential attentional allocation compared to juvenile or adult faces. Therefore, this study investigated attentional allocation to a variety of different aged faces (infants, pre-adolescent children, adolescents, and adults) in 84 adult women, 39 of whom were mothers. Consistent with previous findings, infant faces were found to elicit greater attentional engagement compared to pre-adolescent, adolescent, or adult faces, particularly when the infants displayed distress; again, this effect was more pronounced in mothers compared to non-mothers. Pre-adolescent child faces were also found to elicit greater attentional engagement compared to adolescent and adult faces, but only when they displayed distress. No preferential attentional allocation was observed for adolescent compared to adult faces. These findings indicate that cues potentially signalling vulnerability, specifically age and sad affect, interact to engage attention. They point to a potentially important mechanism, which helps facilitate caregiving behaviour. PMID:25353640

Risk-Sensitive Decision-Making Deficit in Adolescent Suicide Attempters

PubMed Central

Ackerman, John P; McBee-Strayer, Sandy M; Mendoza, Kristen; Stevens, Jack; Sheftall, Arielle H; Campo, John V

2015-01-01

Abstract Objective: Suicide among adolescents is a major public health problem. Decision-making deficits may play an important role in vulnerability to suicidal behavior, but few studies have examined decision-making performance in youth at risk for suicide. In this study, we seek to extend recent findings that adolescent suicide attempters process risk evaluations differently than adolescents who have not attempted suicide. Methods: We assessed decision-making in 14 adolescent suicide attempters and 14 non-attempter comparison subjects, ages 15–19, using the Cambridge Gambling Task (CGT). Each participant was also administered a diagnostic interview (Mini-International Neuropsychiatric Interview [MINI]), structured suicide severity measures, and a brief intelligence quotient (IQ) measure. Results: After controlling for gender and IQ differences, suicide attempters displayed an elevated risk-taking propensity on the CGT relative to comparison subjects, such that they were more willing to take a large risk with their bank of points, a decision-making style that proves disadvantageous over time. No group differences in the latency or accuracy of decision-making were observed. Conclusions: Adolescents with a history of suicide attempt display increased risk-taking and greater difficulty predicting probable outcomes on the CGT. Such deficits have been associated with dysfunction in the orbitofrontal prefrontal cortex, which supports other studies implicating impaired decision-making among individuals with a history of suicide attempt. PMID:25265242

Increased susceptibility to fungal disease accompanies adaptation to drought in Brassica rapa.

PubMed

O'Hara, Niamh B; Rest, Joshua S; Franks, Steven J

2016-01-01

Recent studies have demonstrated adaptive evolutionary responses to climate change, but little is known about how these responses may influence ecological interactions with other organisms, including natural enemies. We used a resurrection experiment in the greenhouse to examine the effect of evolutionary responses to drought on the susceptibility of Brassica rapa plants to a fungal pathogen, Alternaria brassicae. In agreement with previous studies in this population, we found an evolutionary shift to earlier flowering postdrought, which was previously shown to be adaptive. Here, we report the novel finding that postdrought descendant plants were also more susceptible to disease, indicating a rapid evolutionary shift to increased susceptibility. This was accompanied by an evolutionary shift to increased specific leaf area (thinner leaves) following drought. We found that flowering time and disease susceptibility displayed plastic responses to experimental drought treatments, but that this plasticity did not match the direction of evolution, indicating that plastic and evolutionary responses to changes in climate can be opposed. The observed evolutionary shift to increased disease susceptibility accompanying adaptation to drought provides evidence that even if populations can rapidly adapt in response to climate change, evolution in other traits may have ecological effects that could make species more vulnerable. © 2015 The Author(s). Evolution © 2015 The Society for the Study of Evolution.

Evidence of population resistance to extreme low flows in a fluvial-dependent fish species

USGS Publications Warehouse

Katz, Rachel A.; Freeman, Mary C.

2015-01-01

Extreme low streamflows are natural disturbances to aquatic populations. Species in naturally intermittent streams display adaptations that enhance persistence during extreme events; however, the fate of populations in perennial streams during unprecedented low-flow periods is not well-understood. Biota requiring swift-flowing habitats may be especially vulnerable to flow reductions. We estimated the abundance and local survival of a native fluvial-dependent fish species (Etheostoma inscriptum) across 5 years encompassing historic low flows in a sixth-order southeastern USA perennial river. Based on capturemark-recapture data, the study shoal may have acted as a refuge during severe drought, with increased young-of-the-year (YOY) recruitment and occasionally high adult immigration. Contrary to expectations, summer and autumn survival rates (30 days) were not strongly depressed during low-flow periods, despite 25%-80% reductions in monthly discharge. Instead, YOY survival increased with lower minimum discharge and in response to small rain events that increased low-flow variability. Age-1+ fish showed the opposite pattern, with survival decreasing in response to increasing low-flow variability. Results from this population dynamics study of a small fish in a perennial river suggest that fluvial-dependent species can be resistant to extreme flow reductions through enhanced YOY recruitment and high survival

Review Article: A comparison of flood and earthquake vulnerability assessment indicators

NASA Astrophysics Data System (ADS)

de Ruiter, Marleen C.; Ward, Philip J.; Daniell, James E.; Aerts, Jeroen C. J. H.

2017-07-01

In a cross-disciplinary study, we carried out an extensive literature review to increase understanding of vulnerability indicators used in the disciplines of earthquake- and flood vulnerability assessments. We provide insights into potential improvements in both fields by identifying and comparing quantitative vulnerability indicators grouped into physical and social categories. Next, a selection of index- and curve-based vulnerability models that use these indicators are described, comparing several characteristics such as temporal and spatial aspects. Earthquake vulnerability methods traditionally have a strong focus on object-based physical attributes used in vulnerability curve-based models, while flood vulnerability studies focus more on indicators applied to aggregated land-use classes in curve-based models. In assessing the differences and similarities between indicators used in earthquake and flood vulnerability models, we only include models that separately assess either of the two hazard types. Flood vulnerability studies could be improved using approaches from earthquake studies, such as developing object-based physical vulnerability curve assessments and incorporating time-of-the-day-based building occupation patterns. Likewise, earthquake assessments could learn from flood studies by refining their selection of social vulnerability indicators. Based on the lessons obtained in this study, we recommend future studies for exploring risk assessment methodologies across different hazard types.

Predicting Vulnerability Risks Using Software Characteristics

ERIC Educational Resources Information Center

Roumani, Yaman

2012-01-01

Software vulnerabilities have been regarded as one of the key reasons for computer security breaches that have resulted in billions of dollars in losses per year (Telang and Wattal 2005). With the growth of the software industry and the Internet, the number of vulnerability attacks and the ease with which an attack can be made have increased. From…

Declining vulnerability to river floods and the global benefits of adaptation

NASA Astrophysics Data System (ADS)

Jongman, Brenden; Winsemius, Hessel; Aerts, Jeroen; Coughlan de Perez, Erin; Van Aalst, Maarten; Kron, Wolfgang; Ward, Philip

2016-04-01

The global impacts of river floods are substantial and rising. Effective adaptation to the increasing risks requires an in-depth understanding of the physical and socioeconomic drivers of risk. Whilst the modeling of flood hazard and exposure has improved greatly, compelling evidence on spatiotemporal patterns in vulnerability of societies around the world is lacking. Hence, the effects of vulnerability on global flood risk are not fully understood, and future projections of fatalities and losses available today are based on simplistic assumptions or do not include vulnerability. In this study, we show that trends and fluctuations in vulnerability to river floods around the world can be estimated by dynamic high-resolution modeling of flood hazard and exposure. We show that fatalities and losses as a share of exposed population and gross domestic product are decreasing with rising income. We also show that there is a tendency of convergence in vulnerability levels between low- and high-income countries. Based on these findings, we simulate future flood impacts per country using traditional assumptions of static vulnerability through time, but also using future assumptions on reduced vulnerability in the future. We show that future risk increases can be largely contained using effective disaster risk reduction strategies, including a reduction of vulnerability. The study was carried out using the global flood risk model, GLOFRIS, combined with high-resolution time-series maps of hazard and exposure at the global scale. Based on: Jongman et al., 2015. Proceedings of the National Academy of Sciences of the United States of America, doi:10.1073/pnas.1414439112.

The impact of epidemics on labor market: identifying victims of the Middle East Respiratory Syndrome in the Korean labor market.

PubMed

Lee, Ayoung; Cho, Joonmo

2016-12-01

The vulnerability approach suggests that disasters such as epidemics have different effects according not only to physical vulnerability but also to economic class (status). This paper examines the effect of the Middle East Respiratory Syndrome epidemic on the labor market to investigate whether vulnerable groups become more vulnerable due to an interaction between the socio-economic structure and physical risk. This paper examines the effect of the Middle East Respiratory Syndrome epidemic on the labor market by considering unemployment status, job status, working hours, reason for unemployment and underemployment status. In particular, the study investigates whether the U-shaped curve becomes a J-shaped curve due to the interaction between medical vulnerability and labor market vulnerability after an outbreak, assuming that the relative vulnerability in the labor market by age shows a U curve with peaks for the young group and middle aged and old aged groups using the Economically Active Population Survey. We use the difference in difference approach and also conduct a falsification check and robustness check. The results suggest that older workers faced a higher possibility of unemployment after the Middle East Respiratory Syndrome outbreak. In particular, they experienced higher involuntary unemployment and underemployment status as well as decreased working hours. It was confirmed that the relative vulnerability of the labor market for older workers was higher than for the other age groups after the epidemic outbreak due to the double whammy of vulnerability in the medical and labor market. The vulnerability in the young group partially increased compared to the 30s and 40s age groups due to their relative vulnerability in the labor market despite being healthy. We find that assuming the relative vulnerability in the existing labor market shows a U shape with age increase, the U-shaped curve became J-shaped after the outbreak. Disasters like epidemics can occur unexpectedly and affect certain groups more than other. Therefore, medical protection should be enhanced for groups vulnerable to disease and economic measures are also required for the protection of their livelihoods in the labor market to prevent unemployment stemming from inequality.

Cumulative stress and substantiated maltreatment: the importance of caregiver vulnerability and adult partner violence.

PubMed

Wekerle, Christine; Wall, Anne-Marie; Leung, Eman; Trocmé, Nico

2007-04-01

Our goal is to assess the effect of caregiver vulnerabilities, singly and in combination, on the substantiation of child abuse (physical, sexual) and neglect, while controlling for relevant background variables. We test the moderator role of adult partner violence in qualifying the relationship between caregiver vulnerabilities and maltreatment substantiation. Secondary analyses of the 1998 Canadian Incidence Study of Reported Child Maltreatment (CIS) are used to predict child protective service investigation substantiation versus non-substantiation from a range of caregiver vulnerability factors. Involvement in partner violence was examined as a moderator in the relation between caregiver vulnerabilities and maltreatment substantiation. The CIS is an epidemiological survey of first-reported cases to child protective services, using a random sample of child welfare agencies across Canada. Child welfare workers completed a research form on the child, primary caregiver, family, perpetrator, severity and type of maltreatment, as well as services and court outcomes. All maltreatment classifications were assigned according to the Canadian legal definition of child abuse and neglect. Hierarchical logistic regression analyses were used, with stepped entry of: (1) demographic factors, socioeconomic disadvantage, and caregiver's own history of maltreatment; (2) caregiver vulnerability factors; (3) involvement in partner violence; (4) the interaction between caregiver vulnerability and partner violence. Caregiver substance abuse was found to be the single most potent kind of caregiver vulnerability in predicting maltreatment substantiation. When the total number of vulnerabilities was used as the predictor, prediction across all types of maltreatment increased, especially for substantiated neglect. Analyses also showed that the presence of partner violence in the home exacerbated the effect of caregiver vulnerability on substantiation. The total number of caregiver vulnerabilities was the best predictor of the substantiation of child abuse and neglect. This relationship was moderated by the existence of partner violence: high caregiver vulnerability and high partner violence increased the likelihood of substantiation versus non-substantiation. These results suggest that caregiver issues should be considered in tandem with partner relationships. Among child welfare cases, caregiver vulnerability and partner violence are critical targets for child maltreatment prevention and early child protective services intervention.

Tripartite Governance: Enabling Successful Implementations with Vulnerable Populations.

PubMed

Kennedy, Margaret Ann

2016-01-01

Vulnerable populations are often at a distinct disadvantage when it comes to the implementation of health information systems in an equitable, appropriate, and timely manner. The disadvantages experienced by vulnerable populations are innumerable and include lack of representation, lack of appropriate levels of funding, lack of resources and capacity, and lack of representation. Increasingly, models of representation for complex implementations involve a tripartite project governance model. This tripartite partnership distributes accountability across all partners, and ensures that vulnerable populations have an equitable contribution to the direction of implementation according to their needs. This article shares lessons learned and best practices from complex tripartite partnerships supporting implementations with vulnerable populations in Canada.

Use of mobile devices for medical imaging.

PubMed

Hirschorn, David S; Choudhri, Asim F; Shih, George; Kim, Woojin

2014-12-01

Mobile devices have fundamentally changed personal computing, with many people forgoing the desktop and even laptop computer altogether in favor of a smaller, lighter, and cheaper device with a touch screen. Doctors and patients are beginning to expect medical images to be available on these devices for consultative viewing, if not actual diagnosis. However, this raises serious concerns with regard to the ability of existing mobile devices and networks to quickly and securely move these images. Medical images often come in large sets, which can bog down a network if not conveyed in an intelligent manner, and downloaded data on a mobile device are highly vulnerable to a breach of patient confidentiality should that device become lost or stolen. Some degree of regulation is needed to ensure that the software used to view these images allows all relevant medical information to be visible and manipulated in a clinically acceptable manner. There also needs to be a quality control mechanism to ensure that a device's display accurately conveys the image content without loss of contrast detail. Furthermore, not all mobile displays are appropriate for all types of images. The smaller displays of smart phones, for example, are not well suited for viewing entire chest radiographs, no matter how small and numerous the pixels of the display may be. All of these factors should be taken into account when deciding where, when, and how to use mobile devices for the display of medical images. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Climate volatility deepens poverty vulnerability in developing countries

NASA Astrophysics Data System (ADS)

Ahmed, Syud A.; Diffenbaugh, Noah S.; Hertel, Thomas W.

2009-07-01

Extreme climate events could influence poverty by affecting agricultural productivity and raising prices of staple foods that are important to poor households in developing countries. With the frequency and intensity of extreme climate events predicted to change in the future, informed policy design and analysis requires an understanding of which countries and groups are going to be most vulnerable to increasing poverty. Using a novel economic-climate analysis framework, we assess the poverty impacts of climate volatility for seven socio-economic groups in 16 developing countries. We find that extremes under present climate volatility increase poverty across our developing country sample—particularly in Bangladesh, Mexico, Indonesia, and Africa—with urban wage earners the most vulnerable group. We also find that global warming exacerbates poverty vulnerability in many nations.

Neural correlates of reward processing in adults with 22q11 deletion syndrome.

PubMed

van Duin, Esther D A; Goossens, Liesbet; Hernaus, Dennis; da Silva Alves, Fabiana; Schmitz, Nicole; Schruers, Koen; van Amelsvoort, Therese

2016-01-01

22q11.2 deletion syndrome (22q11DS) is caused by a microdeletion on chromosome 22q11.2 and associated with an increased risk to develop psychosis. The gene coding for catechol-O-methyl-transferase (COMT) is located at the deleted region, resulting in disrupted dopaminergic neurotransmission in 22q11DS, which may contribute to the increased vulnerability for psychosis. A dysfunctional motivational reward system is considered one of the salient features in psychosis and thought to be related to abnormal dopaminergic neurotransmission. The functional anatomy of the brain reward circuitry has not yet been investigated in 22q11DS. This study aims to investigate neural activity during anticipation of reward and loss in adult patients with 22q11DS. We measured blood-oxygen-level dependent (BOLD) activity in 16 patients with 22q11DS and 12 healthy controls during a monetary incentive delay task using a 3T Philips Intera MRI system. Data were analysed using SPM8. During anticipation of reward, the 22q11DS group alone displayed significant activation in bilateral middle frontal and temporal brain regions. Compared to healthy controls, significantly less activation in bilateral cingulate gyrus extending to premotor, primary motor and somatosensory areas was found. During anticipation of loss, the 22q11DS group displayed activity in the left middle frontal gyrus and anterior cingulate cortex, and relative to controls, they showed reduced brain activation in bilateral (pre)cuneus and left posterior cingulate. Within the 22q11DS group, COMT Val hemizygotes displayed more activation compared to Met hemizygotes in right posterior cingulate and bilateral parietal regions during anticipation of reward. During anticipation of loss, COMT Met hemizygotes compared to Val hemizygotes showed more activation in bilateral insula, striatum and left anterior cingulate. This is the first study to investigate reward processing in 22q11DS. Our preliminary results suggest that people with 22q11DS engage a fronto-temporal neural network. Compared to healthy controls, people with 22q11DS primarily displayed reduced activity in medial frontal regions during reward anticipation. COMT hemizygosity affects responsivity of the reward system in this condition. Alterations in reward processing partly underlain by the dopamine system may play a role in susceptibility for psychosis in 22q11DS.

Modelling social vulnerability in sub-Saharan West Africa using a geographical information system

PubMed Central

Arokoyu, Samuel B.

2015-01-01

In recent times, disasters and risk management have gained significant attention, especially with increasing awareness of the risks and increasing impact of natural and other hazards especially in the developing world. Vulnerability, the potential for loss of life or property from disaster, has biophysical or social dimensions. Social vulnerability relates to societal attributes which has negative impacts on disaster outcomes. This study sought to develop a spatially explicit index of social vulnerability, thus addressing the dearth of research in this area in sub-Saharan Africa. Nineteen variables were identified covering various aspects. Descriptive analysis of these variables revealed high heterogeneity across the South West region of Nigeria for both the state and the local government areas (LGAs). Feature identification using correlation analysis identified six important variables. Factor analysis identified two dimensions, namely accessibility and socioeconomic conditions, from this subset. A social vulnerability index (SoVI) showed that Ondo and Ekiti have more vulnerable LGAs than other states in the region. About 50% of the LGAs in Osun and Ogun have a relatively low social vulnerability. Distribution of the SoVI shows that there are great differences within states as well as across regions. Scores of population density, disability and poverty have a high margin of error in relation to mean state scores. The study showed that with a geographical information system there are opportunities to model social vulnerability and monitor its evolution and dynamics across the continent.

Construction of road network vulnerability evaluation index based on general travel cost

NASA Astrophysics Data System (ADS)

Leng, Jun-qiang; Zhai, Jing; Li, Qian-wen; Zhao, Lin

2018-03-01

With the development of China's economy and the continuous improvement of her urban road network, the vulnerability of the urban road network has attracted increasing attention. Based on general travel cost, this work constructs the vulnerability evaluation index for the urban road network, and evaluates the vulnerability of the urban road network from the perspective of user generalised travel cost. Firstly, the generalised travel cost model is constructed based on vehicle cost, travel time, and traveller comfort. Then, the network efficiency index is selected as an evaluation index of vulnerability: the network efficiency index is composed of the traffic volume and the generalised travel cost, which are obtained from the equilibrium state of the network. In addition, the research analyses the influence of traffic capacity decrease, road section attribute value, and location of road section, on vulnerability. Finally, the vulnerability index is used to analyse the local area network of Harbin and verify its applicability.

Parenting Moderates a Genetic Vulnerability Factor in Longitudinal Increases in Youths' Substance Use

ERIC Educational Resources Information Center

Brody, Gene H.; Beach, Steven R. H.; Philibert, Robert A.; Chen, Yi-fu; Lei, Man-Kit; Murry, Velma McBride; Brown, Anita C.

2009-01-01

The authors used a longitudinal, prospective design to investigate a moderation effect in the association between a genetic vulnerability factor, a variable nucleotide repeat polymorphism in the promoter region of "5HTT" (5-HTTLPR), and increases in youths' substance use. The primary study hypothesis predicted that involved-supportive…

Entanglement distillation by dissipation and continuous quantum repeaters.

PubMed

Vollbrecht, Karl Gerd H; Muschik, Christine A; Cirac, J Ignacio

2011-09-16

Even though entanglement is very vulnerable to interactions with the environment, it can be created by purely dissipative processes. Yet, the attainable degree of entanglement is profoundly limited in the presence of noise sources. We show that distillation can also be realized dissipatively, such that a highly entangled steady state is obtained. The schemes put forward here display counterintuitive phenomena, such as improved performance if noise is added to the system. We also show how dissipative distillation can be employed in a continuous quantum repeater architecture, in which the resources scale polynomially with the distance.

Parental overprotection and its relation to perceived child vulnerability.

PubMed

Thomasgard, M; Metz, W P

1997-04-01

A study of 280 parents with a child age 5-10 years examined the relation between and correlates of parental overprotection (less education, younger child age, being an only child) and parental perception of increased child vulnerability (history of life-threatening illness, child medical condition, first child). One-third of parents who considered their child vulnerable were also considered overprotective.

Outcomes of a Behavioral Intervention to Reduce HIV Risk among Drug-involved Female Sex Workers

PubMed Central

Surratt, Hilary L.; O’Grady, Catherine; Kurtz, Steven P.; Levi-Minzi, Maria A.; Chen, Minxing

2014-01-01

Although street-based female sex workers (FSWs) are highly vulnerable to HIV, they often lack access to needed health services and medical care. This paper reports the results of a recently completed randomized intervention trial for FSWs in Miami, Florida, which tested the relative efficacy of two case management interventions that aimed to link underserved FSWs with health services and to reduce risk behaviors for HIV. Participants were recruited using targeted sampling strategies and were randomly assigned to: a Strengths-Based/Professional Only (PO) or a Strengths-Based/Professional-Peer condition (PP). Follow-up data were collected 3 and 6 months post-baseline. Outcome analyses indicated that both intervention groups displayed significant reductions in HIV risk behaviors and significant increases in services utilization; the Professional-Peer condition provided no added benefit. HIV seropositive FSWs responded particularly well to the interventions, suggesting the utility of brief strengths-based case management interventions for this population in future initiatives. PMID:24558098

Intolerance of uncertainty as the vulnerability factor among parents of childhood cancer survivors: A 3-month follow-up study.

PubMed

Vander Haegen, Marie; Etienne, Anne-Marie

2018-05-14

In a 3-month follow-up study, we assessed the intolerance of uncertainty in 61 parents of a childhood cancer survivor. The objective was to compare its prevalence over time. We tested these parents twice i.e., at treatment completion (time 1) and 3 months later (time 2). We hypothesized that this personality factor stayed stable and had aversive effects on cognitive processes. Noticeable intolerance of uncertainty rates were found. At both assessments, results showed that this factor was central in the development of excessive worries, poor problem orientation, rumination, cognitive avoidance and positive beliefs about worry. Repeated measures revealed a decrease for anxiety and cognitive avoidance, and an increased level for somatic symptoms. Parents who are intolerant of uncertainty are at risk to display dysfunctional behaviors over time. Sensitizing health care professionals to the identification of this factor and its associated difficulties is essential for the implementation of efficient intervention strategies.

Ballistics reviews: mechanisms of bullet wound trauma.

PubMed

Maiden, Nicholas

2009-01-01

The location of an entrance wound (bullet placement) and the projectile path are the most important factors in causing significant injury or death following a shooting. The head followed by the torso are the most vulnerable areas, with incapacitation resulting from central nervous system (brain or cord) disruption, or massive organ destruction with hemorrhage. Tissue and organ trauma result from the permanent wound cavity caused by direct destruction by the bullet, and also from radial stretching of surrounding tissues causing a temporary wound cavity. The extent of tissue damage is influenced by the type of bullet, its velocity and mass, as well as the physical characteristics of the tissues. The latter includes resistance to strain, physical dimensions of an organ, and the presence or absence of surrounding anatomical constraints. Bullet shape and construction will also affect tissue damage and bullets which display greater yaw will be associated with increased temporary cavitation. Military bullet designs do not include bullets that will expand or flatten as these cause greater wound trauma and are regulated by convention.

The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity.

PubMed

Miner, Jonathan J; Daniels, Brian P; Shrestha, Bimmi; Proenca-Modena, Jose L; Lew, Erin D; Lazear, Helen M; Gorman, Matthew J; Lemke, Greg; Klein, Robyn S; Diamond, Michael S

2015-12-01

The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen host innate immune responses following engagement with their ligands Gas6 and Protein S, which recognize phosphatidylserine on apoptotic cells. In a form of apoptotic mimicry, many enveloped viruses display phosphatidylserine on the outer leaflet of their membranes, enabling TAM receptor activation and downregulation of antiviral responses. Accordingly, we hypothesized that a deficiency of TAM receptors would enhance antiviral responses and protect against viral infection. Unexpectedly, mice lacking Mertk and/or Axl, but not Tyro3, exhibited greater vulnerability to infection with neuroinvasive West Nile and La Crosse encephalitis viruses. This phenotype was associated with increased blood-brain barrier permeability, which enhanced virus entry into and infection of the brain. Activation of Mertk synergized with interferon-β to tighten cell junctions and prevent virus transit across brain microvascular endothelial cells. Because TAM receptors restrict pathogenesis of neuroinvasive viruses, these findings have implications for TAM antagonists that are currently in clinical development.

Protecting vulnerable populations from pandemic influenza in the United States: a strategic imperative.

PubMed

Hutchins, Sonja S; Truman, Benedict I; Merlin, Toby L; Redd, Stephen C

2009-10-01

Protecting vulnerable populations from pandemic influenza is a strategic imperative. The US national strategy for pandemic influenza preparedness and response assigns roles to governments, businesses, civic and community-based organizations, individuals, and families. Because influenza is highly contagious, inadequate preparedness or untimely response in vulnerable populations increases the risk of infection for the general population. Recent public health emergencies have reinforced the importance of preparedness and the challenges of effective response among vulnerable populations. We explore definitions and determinants of vulnerable, at-risk, and special populations and highlight approaches for ensuring that pandemic influenza preparedness includes these populations and enables them to respond appropriately. We also provide an overview of population-specific and cross-cutting articles in this theme issue on influenza preparedness for vulnerable populations.

Protecting Vulnerable Populations From Pandemic Influenza in the United States: A Strategic Imperative

PubMed Central

Truman, Benedict I.; Merlin, Toby L.; Redd, Stephen C.

2009-01-01

Protecting vulnerable populations from pandemic influenza is a strategic imperative. The US national strategy for pandemic influenza preparedness and response assigns roles to governments, businesses, civic and community-based organizations, individuals, and families. Because influenza is highly contagious, inadequate preparedness or untimely response in vulnerable populations increases the risk of infection for the general population. Recent public health emergencies have reinforced the importance of preparedness and the challenges of effective response among vulnerable populations. We explore definitions and determinants of vulnerable, at-risk, and special populations and highlight approaches for ensuring that pandemic influenza preparedness includes these populations and enables them to respond appropriately. We also provide an overview of population-specific and cross-cutting articles in this theme issue on influenza preparedness for vulnerable populations. PMID:19797737

A Heat Vulnerability Index and Adaptation Solutions for Pittsburgh, Pennsylvania.

PubMed

Bradford, Kathryn; Abrahams, Leslie; Hegglin, Miriam; Klima, Kelly

2015-10-06

With increasing evidence of global warming, many cities have focused attention on response plans to address their populations' vulnerabilities. Despite expected increased frequency and intensity of heat waves, the health impacts of such events in urban areas can be minimized with careful policy and economic investments. We focus on Pittsburgh, Pennsylvania and ask two questions. First, what are the top factors contributing to heat vulnerability and how do these characteristics manifest geospatially throughout Pittsburgh? Second, assuming the City wishes to deploy additional cooling centers, what placement will optimally address the vulnerability of the at risk populations? We use national census data, ArcGIS geospatial modeling, and statistical analysis to determine a range of heat vulnerability indices and optimal cooling center placement. We find that while different studies use different data and statistical calculations, all methods tested locate additional cooling centers at the confluence of the three rivers (Downtown), the northeast side of Pittsburgh (Shadyside/Highland Park), and the southeast side of Pittsburgh (Squirrel Hill). This suggests that for Pittsburgh, a researcher could apply the same factor analysis procedure to compare data sets for different locations and times; factor analyses for heat vulnerability are more robust than previously thought.

Beyond exposure, sensitivity and adaptive capacity: A response based ecological framework to assess species climate change vulnerability

USGS Publications Warehouse

Fortini, Lucas B.; Schubert, Olivia

2017-01-01

As the impacts of global climate change on species are increasingly evident, there is a clear need to adapt conservation efforts worldwide. Species vulnerability assessments (VAs) are increasingly used to summarize all relevant information to determine a species’ potential vulnerability to climate change and are frequently the first step in informing climate adaptation efforts. VAs commonly integrate multiple sources of information by utilizing a framework that distinguishes factors relevant to species exposure, sensitivity, and adaptive capacity. However, this framework was originally developed for human systems, and its use to evaluate species vulnerability has serious practical and theoretical limitations. By instead defining vulnerability as the degree to which a species is unable to exhibit any of the responses necessary for persistence under climate change (i.e., toleration of projected changes, migration to new climate-compatible areas, enduring in microrefugia, and evolutionary adaptation), we can bring VAs into the realm of ecological science without applying borrowed abstract concepts that have consistently challenged species-centric research and management. This response-based framework to assess species vulnerability to climate change allows better integration of relevant ecological data and past research, yielding results with much clearer implications for conservation and research prioritization.

Asset ownership among households caring for orphans and vulnerable children in rural Zimbabwe: The influence of ownership on children's health and social vulnerabilities

PubMed Central

Crea, Thomas M.; Lombe, Margaret; Robertson, Laura A.; Dumba, Lovemore; Mushati, Phyllis; Makoni, J.C.; Mavise, Gideon; Eaton, Jeffrey W.; Munatsi, Brighton; Nyamukapa, Constance A.; Gregson, Simon

2012-01-01

The high prevalence of human immunodeficiency virus/acquired immune deficiency syndrome in sub-Saharan Africa has resulted in a dramatic increase in orphans and vulnerable children (OVC) over the past decade. These children typically rely on extended family networks for support, but the magnitude of the crisis has resulted in traditional familial networks becoming overwhelmed and more economically and socially vulnerable. Previous research consistently demonstrates the positive influence of household asset ownership on children's well-being. Using data from impoverished households caring for OVC in rural Manicaland Province, Zimbabwe, this study explores the influence of household asset ownership on OVC health vulnerability (HV) and social vulnerability (SV). Findings indicate that asset ownership is associated with significantly lower SV, in terms of school attendance and birth registration. Yet, assets do not emerge as a direct influence of OVC HV as measured by disease and chronic illness, although having a chronically ill adult in the household increases HV. These findings suggest that asset ownership, specifically a combination of fixed and movable assets, may offset the influence of other risk factors for children's SV. PMID:22624868

A Heat Vulnerability Index and Adaptation Solutions for Pittsburgh, Pennsylvania

NASA Astrophysics Data System (ADS)

Klima, K.; Abrahams, L.; Bradford, K.; Hegglin, M.

2015-12-01

With increasing evidence of global warming, many cities have focused attention on response plans to address their populations' vulnerabilities. Despite expected increased frequency and intensity of heat waves, the health impacts of such events in urban areas can be minimized with careful policy and economic investments. We focus on Pittsburgh, Pennsylvania and ask two questions. First, what are the top factors contributing to heat vulnerability and how do these characteristics manifest geospatially throughout Pittsburgh? Second, assuming the City wishes to deploy additional cooling centers, what placement will optimally address the vulnerability of the at risk populations? We use national census data, ArcGIS geospatial modeling, and statistical analysis to determine a range of heat vulnerability indices and optimal cooling center placement. We find that while different studies use different data and statistical calculations, all methods tested locate additional cooling centers at the confluence of the three rivers (Downtown), the northeast side of Pittsburgh (Shadyside/ Highland Park), and the southeast side of Pittsburgh (Squirrel Hill). This suggests that for Pittsburgh, a researcher could apply the same factor analysis procedure to compare datasets for different locations and times; factor analyses for heat vulnerability are more robust than previously thought.

Asset ownership among households caring for orphans and vulnerable children in rural Zimbabwe: the influence of ownership on children's health and social vulnerabilities.

PubMed

Crea, Thomas M; Lombe, Margaret; Robertson, Laura A; Dumba, Lovemore; Mushati, Phyllis; Makoni, J C; Mavise, Gideon; Eaton, Jeffrey W; Munatsi, Brighton; Nyamukapa, Constance A; Gregson, Simon

2013-01-01

The high prevalence of human immunodeficiency virus/acquired immune deficiency syndrome in sub-Saharan Africa has resulted in a dramatic increase in orphans and vulnerable children (OVC) over the past decade. These children typically rely on extended family networks for support, but the magnitude of the crisis has resulted in traditional familial networks becoming overwhelmed and more economically and socially vulnerable. Previous research consistently demonstrates the positive influence of household asset ownership on children's well-being. Using data from impoverished households caring for OVC in rural Manicaland Province, Zimbabwe, this study explores the influence of household asset ownership on OVC health vulnerability (HV) and social vulnerability (SV). Findings indicate that asset ownership is associated with significantly lower SV, in terms of school attendance and birth registration. Yet, assets do not emerge as a direct influence of OVC HV as measured by disease and chronic illness, although having a chronically ill adult in the household increases HV. These findings suggest that asset ownership, specifically a combination of fixed and movable assets, may offset the influence of other risk factors for children's SV.

Beyond men and women: a critical perspective on gender and disaster.

PubMed

Gaillard, J C; Sanz, Kristinne; Balgos, Benigno C; Dalisay, Soledad Natalia M; Gorman-Murray, Andrew; Smith, Fagalua; Toelupe, Vaito'a

2017-07-01

Consideration of gender in the disaster sphere has centred almost exclusively on the vulnerability and capacities of women. This trend stems from a polarised Western understanding of gender as a binary concept of man-woman. Such an approach also mirrors the dominant framing of disasters and disaster risk reduction (DRR), emphasising Western standards and practices to the detriment of local, non-Western identities and experiences. This paper argues that the man-woman dichotomy is an insufficient construct with which to address the gendered dimensions of a disaster as it fails to capture the realities of diverse gender minorities in non-Western contexts. The paper presents case studies from the Philippines, Indonesia, and Samoa, where gender minorities display specific patterns of vulnerability associated with their marginal positions in society, yet, importantly, also possess a wide array of endogenous capacities. Recognition of these differences, needs, skills, and unique resources is essential to moving towards inclusive and gender-sensitive DRR. © 2017 The Author(s). Disasters © Overseas Development Institute, 2017.

Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.

PubMed

Akundi, Ravi S; Huang, Zhenyu; Eason, Joshua; Pandya, Jignesh D; Zhi, Lianteng; Cass, Wayne A; Sullivan, Patrick G; Büeler, Hansruedi

2011-01-13

PTEN-induced kinase 1 (PINK1) is linked to recessive Parkinsonism (EOPD). Pink1 deletion results in impaired dopamine (DA) release and decreased mitochondrial respiration in the striatum of mice. To reveal additional mechanisms of Pink1-related dopaminergic dysfunction, we studied Ca²+ vulnerability of purified brain mitochondria, DA levels and metabolism and whether signaling pathways implicated in Parkinson's disease (PD) display altered activity in the nigrostriatal system of Pink1⁻/⁻ mice. Purified brain mitochondria of Pink1⁻/⁻ mice showed impaired Ca²+ storage capacity, resulting in increased Ca²+ induced mitochondrial permeability transition (mPT) that was rescued by cyclosporine A. A subpopulation of neurons in the substantia nigra of Pink1⁻/⁻ mice accumulated phospho-c-Jun, showing that Jun N-terminal kinase (JNK) activity is increased. Pink1⁻/⁻ mice 6 months and older displayed reduced DA levels associated with increased DA turnover. Moreover, Pink1⁻/⁻ mice had increased levels of IL-1β, IL-12 and IL-10 in the striatum after peripheral challenge with lipopolysaccharide (LPS), and Pink1⁻/⁻ embryonic fibroblasts showed decreased basal and inflammatory cytokine-induced nuclear factor kappa-β (NF-κB) activity. Quantitative transcriptional profiling in the striatum revealed that Pink1⁻/⁻ mice differentially express genes that (i) are upregulated in animals with experimentally induced dopaminergic lesions, (ii) regulate innate immune responses and/or apoptosis and (iii) promote axonal regeneration and sprouting. Increased mitochondrial Ca²+ sensitivity and JNK activity are early defects in Pink1⁻/⁻ mice that precede reduced DA levels and abnormal DA homeostasis and may contribute to neuronal dysfunction in familial PD. Differential gene expression in the nigrostriatal system of Pink1⁻/⁻ mice supports early dopaminergic dysfunction and shows that Pink1 deletion causes aberrant expression of genes that regulate innate immune responses. While some differentially expressed genes may mitigate neurodegeneration, increased LPS-induced brain cytokine expression and impaired cytokine-induced NF-κB activation may predispose neurons of Pink1⁻/⁻ mice to inflammation and injury-induced cell death.

Study of groundwater vulnerability to pollution using the DRASTIC method coupled with a geographic information system (GIS): application to groundwater Beni Amir, Morocco

NASA Astrophysics Data System (ADS)

Knouz, Najat; Boudhar, Abdelghani; Bachaoui, El Mostafa

2016-04-01

Fresh water is the condition of all life on Earth for its vital role in the survival of living beings and in the social, economic and technological development. The Groundwater, as the surface water, is increasingly threatened by agricultural and industrial pollution. In this respect, the groundwater vulnerability assessment to pollution is a very valuable tool for resource protection, management of its quality and uses it in a sustainable way. The main objective of this study is the evaluation of groundwater vulnerability to pollution of the study area, Beni Amir, located in the first irrigated perimeter of Morocco, Tadla, using the DRASTIC method (depth to water, net recharge, aquifer media, soil media, Topography, impact of Vadose zone and hydraulic conductivity), and assessing the impact of each parameter on the DRASTIC vulnerability index by a sensitivity analysis. This study also highlights the role of geographic information systems (GIS) in assessing vulnerability. The Vulnerability index is calculated as the sum of product of ratings and weights assigned to each of the parameter DRASTIC. The results revealed four vulnerability classes, 7% of the study area has a high vulnerability, 31% are moderately vulnerable, 57% have a low vulnerability and 5% are of very low vulnerability.

A socioeconomic profile of vulnerable land to desertification in Italy.

PubMed

Salvati, Luca

2014-01-01

Climate changes, soil vulnerability, loss in biodiversity, and growing human pressure are threatening Mediterranean-type ecosystems which are increasingly considered as a desertification hotspot. In this region, land vulnerability to desertification strongly depends on the interplay between natural and anthropogenic factors. The present study proposes a multivariate exploratory analysis of the relationship between the spatial distribution of land vulnerability to desertification and the socioeconomic contexts found in three geographical divisions of Italy (north, center and south) based on statistical indicators. A total of 111 indicators describing different themes (demography, human settlements, labor market and human capital, rural development, income and wealth) were used to discriminate vulnerable from non-vulnerable areas. The resulting socioeconomic profile of vulnerable areas in northern and southern Italy diverged significantly, the importance of demographic and economic indicators being higher in southern Italy than in northern Italy. On the contrary, human settlement indicators were found more important to discriminate vulnerable and non-vulnerable areas in northern Italy, suggesting a role for peri-urbanization in shaping the future vulnerable areas. An in-depth knowledge of the socioeconomic characteristics of vulnerable land may contribute to scenarios' modeling and the development of more effective policies to combat desertification. © 2013 Elsevier B.V. All rights reserved.

An uncertainty-based framework to quantifying climate change impacts on coastal flood vulnerability: case study of New York City.

PubMed

Zahmatkesh, Zahra; Karamouz, Mohammad

2017-10-17

The continued development efforts around the world, growing population, and the increased probability of occurrence of extreme hydrologic events have adversely affected natural and built environments. Flood damages and loss of lives from the devastating storms, such as Irene and Sandy on the East Coast of the USA, are examples of the vulnerability to flooding that even developed countries have to face. The odds of coastal flooding disasters have been increased due to accelerated sea level rise, climate change impacts, and communities' interest to live near the coastlines. Climate change, for instance, is becoming a major threat to sustainable development because of its adverse impacts on the hydrologic cycle. Effective management strategies are thus required for flood vulnerability reduction and disaster preparedness. This paper is an extension to the flood resilience studies in the New York City coastal watershed. Here, a framework is proposed to quantify coastal flood vulnerability while accounting for climate change impacts. To do so, a multi-criteria decision making (MCDM) approach that combines watershed characteristics (factors) and their weights is proposed to quantify flood vulnerability. Among the watershed characteristics, potential variation in the hydrologic factors under climate change impacts is modeled utilizing the general circulation models' (GCMs) outputs. The considered factors include rainfall, extreme water level, and sea level rise that exacerbate flood vulnerability through increasing exposure and susceptibility to flooding. Uncertainty in the weights as well as values of factors is incorporated in the analysis using the Monte Carlo (MC) sampling method by selecting the best-fitted distributions to the parameters with random nature. A number of low impact development (LID) measures are then proposed to improve watershed adaptive capacity to deal with coastal flooding. Potential range of current and future vulnerability to flooding is estimated with and without consideration of climate change impacts and after implementation of LIDs. Results show that climate change has the potential to increase rainfall intensity, flood volume, floodplain extent, and flood depth in the watershed. The results also reveal that improving system resilience by reinforcing the adaptation capacity through implementing LIDs could mitigate flood vulnerability. Moreover, the results indicate the significant effect of uncertainties, arising from the factors' weights as well as climate change, impacts modeling approach, on quantifying flood vulnerability. This study underlines the importance of developing applicable schemes to quantify coastal flood vulnerability for evolving future responses to adverse impacts of climate change.

A Brazilian Vulnerability Index Towards Natural Disasters and Climatic Change - Flashfloods and Landslides.

NASA Astrophysics Data System (ADS)

Debortoli, N. S.; Camarinha, P. I., Sr.; Marengo, J. A.; Rodrigues, R.

2015-12-01

There are some evidences that hydrological climate extremes events have become more frequent an intense in the last decades due to climatic change. In Brazil, flashfloods and landslides were responsible for 74% of the deaths related to natural disasters in 1991-2010 period. In this sense, climate change could be considered a threat which can further increase these numbers, if actions of adaptation and reducing vulnerability are not taken. To evaluate Brazil's vulnerability hotspots to these disasters, two vulnerability indexes were developed using three sets of variables: (1) climate, with IPCC climate extreme indexes; (2) environmental, including land use, drainage systems, relief map, slope, road density and hydrography variables; (3) socioeconomic, including Gini coefficient, HDI (Human Development Index), housing conditions and poverty-related index. The variables were normalized on a scale between 0 to 1 and related using Map Algebra technique (ArcGIS). As part of the effort to contribute to the elaboration of the Third National Communication to the United Nations Framework Convention on Climate Change (UNFCCC), and to contribute to the assessment of impacts on strategic country's issues, simulations at higher resolution were carried out using Eta-20km RCM (Regional Climate Model) nested with two global climate models: HadGEM ES and MIROC 5 (INPE Brazilian National Institute for Space Research). For the baseline period of 1961-1990, the vulnerability indexes were adjusted by an iterative process, which was validated by comparing it to the Brazilian National Disasters Data. The same indexes found at baseline were used to estimate the vulnerability until the end of the XXI century, using the 4.5 and 8.5 IPCC/AR5 RCP (Representative Concentration Pathways) scenarios. The results indicate a large increase in Brazil's vulnerability to landslides mainly in coastal zone, southern states, high lands of southeast states, and along the Amazon River due to climatic aspects only, not considering other factors such as increase in population size, etc. Flashfloods vulnerability, on the other hand, increases mostly in the south/southeast regions, the northeast coastal zone and parts of the Amazon basin. Funded by: Ministry of Science and Technology of Brazil and the United Nations Development Program in Brazil.

Resilience and Vulnerability to the Psychological Harm From Flooding: The Role of Social Cohesion.

PubMed

Greene, Giles; Paranjothy, Shantini; Palmer, Stephen R

2015-09-01

We examined the role of social cohesion as a component of vulnerability and resilience to the psychological distress of flooding. A survey collected data from 2238 individuals living in flood-affected areas of England (South Yorkshire and Worcestershire) in 2007. We used Bayesian structural equation modeling to assess factors relating to the latent variables of resilience (years in area, family nearby, and social cohesion) and vulnerability (disruption of essential services, flood risk, and previous flood experience). Flooding was strongly associated with poor mental health; however, resilience factors (associated with the ability to cope with natural disasters), but not vulnerability, were strongly associated with a reduction in psychological distress. Resilience and social cohesion were important influences on the risk of developing poor mental health following flooding. Increasing resilience of communities by strengthening social cohesion through measures that increase civic participation and changing land use should be considered as potentially inexpensive and effective defenses against avoidable mental harm that will result from increased climate instability.

Assessment of the vulnerability and the resilience of the population at risk of multi-hazard: a support to geo-risk management in Central Africa

NASA Astrophysics Data System (ADS)

Michellier, Caroline; Kervyn, François; Tréfon, Théodore; Wolff, Eléonore

2013-04-01

GeoRisCA is a project which aims at studying the geo-risk in the Kivu region (DRC, Rwanda, Burundi), in order to support risk management. The approach developed in GeoRisCA combines methodologies from various disciplines, which will allow the analyses of seismic, volcanic and mass-movement hazards and the vulnerability assessment of the threatened elements. Vulnerability is a complex concept which is commonly defined as the susceptibility of the population, the infrastructures and the natural ecosystems to suffer from damages if a hazard occurs. The densely populated area extended from the North Kivu province in Democratic Republic of the Congo (DRC) to North Burundi and East Rwanda is vulnerable to several geohazards, such as landslides triggered by geodynamical processes (climate, seismicity, volcanism) and possibly worsen by anthropic actions. Located in the East African rift valley, the region is also characterized by a strong seismicity, with increasing people and infrastructure exposed. In addition, east DRC hosts the two most active African volcanoes: Nyiragongo and Nyamulagira. Their activity can have serious impacts, as in 2002 when Nyiragongo directly endangers the ~800.000 inhabitants of Goma city, located ~15 km to the south. Linked to passive volcanic degassing, SO2 and CO2 discharge may also increase the population vulnerability(morbidity, mortality). Focusing specifically on this region, the vulnerability assessment methodology developed in GeoRisCA takes into account "exposure to perturbations" and "adaptive capacity or resilience" of the vulnerable systems. On one hand, the exposure is identified as the potential degree of loss of a given element or set of elements at risk; i.e., the susceptibility of people, infrastructures and buildings with respect to a hazard (social vulnerability). It focuses mainly on land use, and on demographic and socio-economic factors that increase or attenuate the impacts of hazards events on local populations. On the other hand, the resilience of the individual, the household, the community, is its adaptive capacity to absorb disturbance and reorganize into a fully functioning system by anticipation, response, adaptation and recovery. A key contribution of GeoRisCA project is to assess the vulnerability to different geohazards by integrating geographic and time variability. This methodology takes into account the specificities highlighted at the regional and the local scale (urban sites). And it also considers that the vulnerability evolves with time, e.g. due to improved education, increased income, denser social networks and evolution of coping mechanisms. Using the above described methodology, one of the main objective of GeoRisCA is to developed vulnerability maps that, once associated with geohazards data, will provide decision making tools for existing preparedness and mitigation institutions.

Are older people a vulnerable group? Philosophical and bioethical perspectives on ageing and vulnerability.

PubMed

Bozzaro, Claudia; Boldt, Joachim; Schweda, Mark

2018-05-01

The elderly are often considered a vulnerable group in public and academic bioethical debates and regulations. In this paper, we examine and challenge this assumption and its ethical implications. We begin by systematically delineating the different concepts of vulnerability commonly used in bioethics, before then examining whether these concepts can be applied to old age. We argue that old age should not, in and of itself, be used as a marker of vulnerability, since ageing is a process that can develop in a variety of different ways and is not always associated with particular experiences of vulnerability. We, therefore, turn to more fundamental phenomenological considerations in order to reconstruct from a first person perspective the intricate interconnections between the experiences of ageing and vulnerability. According to this account, ageing and old age are phenomena in which the basic anthropological vulnerability of human beings can manifest itself in an increased likelihood of harm and exploitation. Thus, we plead for a combined model of vulnerability that helps to avoid problems related to the current concepts of vulnerability. We conclude first that old age as such is not a sufficient criterion for being categorized as vulnerable in applied ethics, and second that reflections on ageing can help to develop a better understanding of the central role of vulnerability in human existence and in applied ethics. © 2018 John Wiley & Sons Ltd.

[Food intake in indigenous and non-indigenous Chilean schoolchildren of different social vulnerability].

PubMed

García, Vanessa; Amigo, Hugo; Bustos, Patricia

2002-12-01

The study was based on a cross-sectional design of children from six to nine year olds. Indigenous children were those whose parents had all surnames of this ethnic origin. Non-indigenous children were those with Hispanic surnames. Participants belonged to one of the three social vulnerability groups: high vulnerability (extreme poverty) living in rural communities in a southern region of the country (n = 184); medium vulnerability living in urbanized settings in the same region (n = 248); low vulnerability living in Santiago of Chile (n = 336). Food intake was estimated using a 24-hours recall questionnaire. Total energy intake was similar in the two ethnic groups in all vulnerabilities. It was observed that energy and macronutrient intake increased with the improvement of the social vulnerability: High 1679 kcal. with a standard deviation (SD) of 461, Medium 1878 (SD 484), Low 1894 (SD 495). Children in the high social vulnerability group had a total energy intake below the WHO/FAO recommendations. Consumption of milk, meat, vegetables and fruits was insufficient in all social vulnerability levels but it was closer to the recommendation in the low vulnerability group. Bread accounted for almost 50% of the total energy intake in the high and medium vulnerability groups. It is concluded that differences in the access to an adequate feeding are related to social vulnerability and not ethnicity.

Political violence and mental health in Nepal: prospective study*†

PubMed Central

Kohrt, Brandon A.; Hruschka, Daniel J.; Worthman, Carol M.; Kunz, Richard D.; Baldwin, Jennifer L.; Upadhaya, Nawaraj; Acharya, Nanda Raj; Koirala, Suraj; Thapa, Suraj B.; Tol, Wietse A.; Jordans, Mark J. D.; Robkin, Navit; Sharma, Vidya Dev; Nepal, Mahendra K.

2012-01-01

Background Post-conflict mental health studies in low-income countries have lacked pre-conflict data to evaluate changes in psychiatric morbidity resulting from political violence. Aims This prospective study compares mental health before and after exposure to direct political violence during the People’s War in Nepal. Method An adult cohort completed the Beck Depression Inventory and Beck Anxiety Inventory in 2000 prior to conflict violence in their community and in 2007 after the war. Results Of the original 316 participants, 298 (94%) participated in the post-conflict assessment. Depression increased from 30.9 to 40.6%. Anxiety increased from 26.2 to 47.7%. Post-conflict post-traumatic stress disorder (PTSD) was 14.1%. Controlling for ageing, the depression increase was not significant. The anxiety increase showed a dose–response association with conflict exposure when controlling for ageing and daily stressors. No demographic group displayed unique vulnerability or resilience to the effects of conflict exposure. Conclusions Conflict exposure should be considered in the context of other types of psychiatric risk factors. Conflict exposure predicted increases in anxiety whereas socioeconomic factors and non-conflict stressful life events were the major predictors of depression. Research and interventions in post-conflict settings therefore should consider differential trajectories for depression v. anxiety and the importance of addressing chronic social problems ranging from poverty to gender and ethnic/caste discrimination. PMID:22878131

Business cycle impacts on substance use of adolescents: A multi-country analysis.

PubMed

Paling, Thomas; Vall Castello, Judit

2017-11-01

Populations respond to changes in the economic climate in a variety of ways. The recent 'Great Recession' has brought attention to the vulnerability of many economies around the world to changes in non-domestic macroeconomic fluctuations. However, empirical evidence on the responses of adolescents' substance consumption behaviour when the economy deteriorates is very scarce. Thus, the focus of this paper is to analyse the substance consumption patterns displayed by adolescents in response to changes in macroeconomic conditions in a large number of countries. Our results show that beer and wine consumption vary counter-cyclically (a 1pp increase in the unemployment rate increases the probability of drinking beer (wine) by 3% (5.5%)) while adolescent smoking prevalence varies pro-cyclically (a 1pp increase in the unemployment rate decreases the probability of being a current smoker by 3.8%). More importantly, we find that the probability of ever being drunk increases by 1.3% for a 1pp increase in the unemployment rate. Further to this, substantial heterogeneous effects from the aggregate-level results were found when analysing a variety of demographic and geographic dimensions. In light of the existing empirical evidence which outlines that early substance initiators demonstrate worse neurological deficits and suffer stronger labour market penalties (compared to later initiators or abstainers) these findings can aid policy makers in reducing these lasting adverse outcomes. Copyright © 2017 Elsevier B.V. All rights reserved.

Creativity and psychopathology: a shared vulnerability model.

PubMed

Carson, Shelley H

2011-03-01

Creativity is considered a positive personal trait. However, highly creative people have demonstrated elevated risk for certain forms of psychopathology, including mood disorders, schizophrenia spectrum disorders, and alcoholism. A model of shared vulnerability explains the relation between creativity and psychopathology. This model, supported by recent findings from neuroscience and molecular genetics, suggests that the biological determinants conferring risk for psychopathology interact with protective cognitive factors to enhance creative ideation. Elements of shared vulnerability include cognitive disinhibition (which allows more stimuli into conscious awareness), an attentional style driven by novelty salience, and neural hyperconnectivity that may increase associations among disparate stimuli. These vulnerabilities interact with superior meta-cognitive protective factors, such as high IQ, increased working memory capacity, and enhanced cognitive flexibility, to enlarge the range and depth of stimuli available in conscious awareness to be manipulated and combined to form novel and original ideas.

Predicting ecosystem vulnerability to biodiversity loss from community composition.

PubMed

Heilpern, Sebastian A; Weeks, Brian C; Naeem, Shahid

2018-05-01

Ecosystems vary widely in their responses to biodiversity change, with some losing function dramatically while others are highly resilient. However, generalizations about how species- and community-level properties determine these divergent ecosystem responses have been elusive because potential sources of variation (e.g., trophic structure, compensation, functional trait diversity) are rarely evaluated in conjunction. Ecosystem vulnerability, or the likely change in ecosystem function following biodiversity change, is influenced by two types of species traits: response traits that determine species' individual sensitivities to environmental change, and effect traits that determine a species' contribution to ecosystem function. Here we extend the response-effect trait framework to quantify ecosystem vulnerability and show how trophic structure, within-trait variance, and among-trait covariance affect ecosystem vulnerability by linking extinction order and functional compensation. Using in silico trait-based simulations we found that ecosystem vulnerability increased when response and effect traits positively covaried, but this increase was attenuated by decreasing trait variance. Contrary to expectations, in these communities, both functional diversity and trophic structure increased ecosystem vulnerability. In contrast, ecosystem functions were resilient when response and effect traits covaried negatively, and variance had a positive effect on resiliency. Our results suggest that although biodiversity loss is often associated with decreases in ecosystem functions, such effects are conditional on trophic structure, and the variation within and covariation among response and effect traits. Taken together, these three factors can predict when ecosystems are poised to lose or gain function with ongoing biodiversity change. © 2018 by the Ecological Society of America.

Medical Students' Empathy for Vulnerable Groups: Results From a Survey and Reflective Writing Assignment.

PubMed

Wellbery, Caroline; Saunders, Pamela A; Kureshi, Sarah; Visconti, Adam

2017-12-01

As medical education curricula increasingly acknowledge the contributions of the social determinants of health to individual health, new methods of engaging students in the care of vulnerable groups are needed. Empathy is one way to connect students with patients, but little is known about how to nurture students' empathy on behalf of populations. This study examined the relationship between individual and social empathy as groundwork for cultivating students' empathy for vulnerable groups. In 2014-2015, first-year medical students completed the Social Empathy Index at the start and end of a two-semester population health course, and they completed a reflective writing assignment exploring the challenges of caring for vulnerable patients. Pre- and posttest mean survey scores were compared, and reflective writing assignments were analyzed for themes concerning social empathy. Data from 130 students were analyzed. Scores for the contextual understanding of systemic barriers domain increased significantly. There was a trend toward increased cumulative social empathy scores that did not reach statistical significance. Students' essays revealed three themes relating to individual empathy as the foundation for social empathy; civic and moral obligations; and the role of institutional practices in caring for vulnerable groups. This study extends understanding of empathy beyond care for the individual to include care for vulnerable groups. Thus, social empathy may function as a valuable concept in developing curricula to support students' commitment to care for the underserved. Educators first need to address the many barriers students cited that impede both individual and social empathy.

An Evaluation of "Miranda" Rights and Interrogation in Autism Spectrum Disorders

ERIC Educational Resources Information Center

Salseda, Lindsay M.; Dixon, Dennis R.; Fass, Tracy; Miora, Deborah; Leark, Robert A.

2011-01-01

The primary deficits present in autism spectrum disorders (ASD) may lead to increased susceptibility to involvement in the criminal justice system. The same deficits may also cause individuals with ASD to be more vulnerable to interrogation techniques and other aspects of the legal system. Due to the increased level of vulnerability as well as…

Multifactorial modulation of susceptibility to l-lysine in an animal model of glutaric aciduria type I.

PubMed

Sauer, Sven W; Opp, Silvana; Komatsuzaki, Shoko; Blank, Anna-Eva; Mittelbronn, Michel; Burgard, Peter; Koeller, D M; Okun, Jürgen G; Kölker, Stefan

2015-05-01

Glutaric aciduria type I is an inherited defect in L-lysine, L-hydroxylysine and L-tryptophan degradation caused by deficiency of glutaryl-CoA dehydrogenase (GCDH). The majority of untreated patients presents with accumulation of neurotoxic metabolites - glutaric acid (GA) and 3-hydroxyglutaric acid (3-OHGA) - and striatal injury. Gcdh(-/-) mice display elevated levels of GA and 3-OH-GA but do not spontaneously develop striatal lesions. L-lysine-enriched diets (appr. 235 mg/d) were suggested to induce a neurological phenotype similar to affected patients. In our hands 93% of mice stressed according to the published protocol remained asymptomatic. To understand the underlying mechanism, we modified their genetic background (F1 C57BL6/Jx129/SvCrl) and increased the daily oral L-lysine supply (235-433 mg). We identified three modulating factors, (1) gender, (2) genetic background, and (3) amount of L-lysine. Male mice displayed higher vulnerability and inbreeding for more than two generations as well as elevating L-lysine supply increased the diet-induced mortality rate (up to 89%). Onset of first symptoms leads to strongly reduced intake of food and, thus, L-lysine suggesting a threshold for toxic metabolite production to induce neurological disease. GA and 3-OH-GA tissue concentrations did not correlate with dietary L-lysine supply but differed between symptomatic and asymptomatic mice. Cerebral activities of glyceraldehyde 3-phosphate dehydrogenase, 2-oxoglutarate dehydrogenase complex, and aconitase were decreased. Symptomatic mice did not develop striatal lesions or intracerebral hemorrhages. We found severe spongiosis in the hippocampus of Gcdh(-/-) mice which was independent of dietary L-lysine supply. In conclusion, the L-lysine-induced pathology in Gcdh(-/-) mice depends on genetic and dietary parameters. Copyright © 2014. Published by Elsevier B.V.

Changes to extreme wave climates of islands within the Western Tropical Pacific throughout the 21st century under RCP 4.5 and RCP 8.5, with implications for island vulnerability and sustainability

USGS Publications Warehouse

Shope, James B.; Storlazzi, Curt; Erikson, Li; Hegermiller, Christie

2016-01-01

Waves are the dominant influence on coastal morphology and ecosystem structure of tropical Pacific islands. Wave heights, periods, and directions for the 21st century were projected using near-surface wind fields from four atmosphere-ocean coupled global climate models (GCM) under representative concentration pathways (RCP) 4.5 and 8.5. GCM-derived wind fields forced the global WAVEWATCH-III wave model to generate hourly time-series of bulk wave parameters around 25 islands in the mid to western tropical Pacific Ocean for historical (1976–2005), mid-, and end-of-century time periods. Extreme significant wave heights decreased (~10.0%) throughout the 21st century under both climate scenarios compared to historical wave conditions and the higher radiative forcing 8.5 scenario displayed a greater and more widespread decrease in extreme significant wave heights compared to the lower forcing 4.5 scenario. An exception was for the end-of-century June–August season. Offshore of islands in the central equatorial Pacific, extreme significant wave heights displayed the largest changes from historical values. The frequency of extreme events during December–February decreased under RCP 8.5, whereas the frequency increased under RCP 4.5. Mean wave directions often rotated more than 30° clockwise at several locations during June–August, which could indicate a weakening of the trade winds’ influence on extreme wave directions and increasing dominance of Southern Ocean swell or eastern shift of storm tracks. The projected changes in extreme wave heights, directions of extreme events, and frequencies at which extreme events occur will likely result in changes to the morphology and sustainability of island nations.

Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9-14 years.

PubMed

Matheson, Sandra L; Vijayan, Hena; Dickson, Hannah; Shepherd, Alana M; Carr, Vaughan J; Laurens, Kristin R

2013-08-01

Social withdrawal is a robust childhood risk factor for later schizophrenia. The aims of this paper were to assess the evidence for childhood social withdrawal among adults with schizophrenia and, comparatively, in children aged 9-14 years who are putatively at-risk of developing schizophrenia. We conducted a meta-analysis, including cohort and case-control studies reporting social withdrawal measured by the Child Behavior Checklist (CBCL) in adults with schizophrenia vs. controls. Further, an experimental study compared CBCL withdrawal scores from typically-developing children with scores from two groups of putatively at-risk children: (i) children displaying a triad of replicated antecedents for schizophrenia, and (ii) children with at least one first- or second-degree relative with schizophrenia or schizoaffective disorder. Six studies met inclusion criteria for the meta-analysis (N = 3828), which demonstrated a large effect of increased childhood social withdrawal in adults with schizophrenia (standardized mean difference [SMD] score = 1.035, 95% CI = 0.304-1.766, p = 0.006), with no indication of publication bias, but considerable heterogeneity (I(2) = 91%). Results from the experimental study also indicated a large effect of increased social withdrawal in children displaying the antecedent triad (SMD = 0.743, p = 0.001), and a weaker effect in children with a family history of schizophrenia (SMD = 0.442, p = 0.051). Childhood social withdrawal may constitute a vulnerability marker for schizophrenia in the presence of other antecedents and/or genetic risk factors for schizophrenia. Copyright © 2013 Elsevier Ltd. All rights reserved.

Software Vulnerability Taxonomy Consolidation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Polepeddi, Sriram S.

2004-12-07

In today's environment, computers and networks are increasing exposed to a number of software vulnerabilities. Information about these vulnerabilities is collected and disseminated via various large publicly available databases such as BugTraq, OSVDB and ICAT. Each of these databases, individually, do not cover all aspects of a vulnerability and lack a standard format among them, making it difficult for end-users to easily compare various vulnerabilities. A central database of vulnerabilities has not been available until today for a number of reasons, such as the non-uniform methods by which current vulnerability database providers receive information, disagreement over which features of amore » particular vulnerability are important and how best to present them, and the non-utility of the information presented in many databases. The goal of this software vulnerability taxonomy consolidation project is to address the need for a universally accepted vulnerability taxonomy that classifies vulnerabilities in an unambiguous manner. A consolidated vulnerability database (CVDB) was implemented that coalesces and organizes vulnerability data from disparate data sources. Based on the work done in this paper, there is strong evidence that a consolidated taxonomy encompassing and organizing all relevant data can be achieved. However, three primary obstacles remain: lack of referencing a common ''primary key'', un-structured and free-form descriptions of necessary vulnerability data, and lack of data on all aspects of a vulnerability. This work has only considered data that can be unambiguously extracted from various data sources by straightforward parsers. It is felt that even with the use of more advanced, information mining tools, which can wade through the sea of unstructured vulnerability data, this current integration methodology would still provide repeatable, unambiguous, and exhaustive results. Though the goal of coalescing all available data, which would be of use to system administrators, software developers and vulnerability researchers is not yet achieved, this work has resulted in the most exhaustive collection of vulnerability data to date.« less

Developing a Composite Aquifer Vulnerability Assessment Model Combining DRASTIC with Agricultural Land Use in Choushui River Alluvial Fan, Central Taiwan

NASA Astrophysics Data System (ADS)

Chen, Shih-Kai; Hsieh, Chih-Heng; Tsai, Cheng-Bin

2017-04-01

Aquifer vulnerability assessment is considered to be an effective tool in controlling potential pollution which is critical for groundwater management. The Choushui River alluvial fan, located in central Taiwan, is an agricultural area with complex crop patterns and various irrigation schemes, which increased the difficulties in groundwater resource management. The aim of this study is to propose an integrated methodology to assess shallow groundwater vulnerability by including land-use impact on groundwater potential pollution. The original groundwater vulnerability methodology, DRASTIC, was modified by adding a land-use parameter in order to assess groundwater vulnerability under intense agricultural activities. To examine the prediction capacity of pollution for the modified DRASTIC model, various risk categories of contamination potentials were compared with observed nitrate-N obtained from groundwater monitoring network. It was found that for the original DRASTIC vulnerability map, some areas with low nitrate-N concentrations are covered within the high vulnerability areas, especially in the northern part of mid-fan areas, where rice paddy is the main crop and planted for two crop seasons per year. The low nitrate-N contamination potential of rice paddies may be resulted from the denitrification in the reduced root zone. By reducing the rating for rice paddies, the modified model was proved to be capable of increasing the precise of prediction in study area. The results can provide a basis for groundwater monitoring network design and effective preserve measures formulation in the mixed agricultural area. Keyword:Aquifer Vulnerability, Groundwater, DRASTIC, Nitrate-N

Integrated flash flood vulnerability assessment: Insights from East Attica, Greece

NASA Astrophysics Data System (ADS)

Karagiorgos, Konstantinos; Thaler, Thomas; Heiser, Micha; Hübl, Johannes; Fuchs, Sven

2016-10-01

In the framework of flood risk assessment, vulnerability is a key concept to assess the susceptibility of elements at risk. Besides the increasing amount of studies on flash floods available, in-depth information on vulnerability in Mediterranean countries was missing so far. Moreover, current approaches in vulnerability research are driven by a divide between social scientists who tend to view vulnerability as representing a set of socio-economic factors, and natural scientists who view vulnerability in terms of the degree of loss to an element at risk. Further, vulnerability studies in response to flash flood processes are rarely answered in the literature. In order to close this gap, this paper implemented an integrated vulnerability approach focusing on residential buildings exposed to flash floods in Greece. In general, both physical and social vulnerability was comparable low, which is interpreted as a result from (a) specific building regulations in Greece as well as general design principles leading to less structural susceptibility of elements at risk exposed, and (b) relatively low economic losses leading to less social vulnerability of citizens exposed. The population show high risk awareness and coping capacity to response to natural hazards event and in the same time the impact of the events are quite low, because of the already high use of local protection measures. The low vulnerability score for East Attica can be attributed especially to the low physical vulnerability and the moderate socio-economic well-being of the area. The consequence is to focus risk management strategies mainly in the reduction of the social vulnerability. By analysing both physical and social vulnerability an attempt was made to bridge the gap between scholars from sciences and humanities, and to integrate the results of the analysis into the broader vulnerability context.

Improving vulnerability models: lessons learned from a comparison between flood and earthquake assessments

NASA Astrophysics Data System (ADS)

de Ruiter, Marleen; Ward, Philip; Daniell, James; Aerts, Jeroen

2017-04-01

In a cross-discipline study, an extensive literature review has been conducted to increase the understanding of vulnerability indicators used in both earthquake- and flood vulnerability assessments, and to provide insights into potential improvements of earthquake and flood vulnerability assessments. It identifies and compares indicators used to quantitatively assess earthquake and flood vulnerability, and discusses their respective differences and similarities. Indicators have been categorized into Physical- and Social categories, and further subdivided into (when possible) measurable and comparable indicators. Physical vulnerability indicators have been differentiated to exposed assets such as buildings and infrastructure. Social indicators are grouped in subcategories such as demographics, economics and awareness. Next, two different vulnerability model types have been described that use these indicators: index- and curve-based vulnerability models. A selection of these models (e.g. HAZUS) have been described, and compared on several characteristics such as temporal- and spatial aspects. It appears that earthquake vulnerability methods are traditionally strongly developed towards physical attributes at an object scale and used in vulnerability curve models, whereas flood vulnerability studies focus more on indicators applied to aggregated land-use scales. Flood risk studies could be improved using approaches from earthquake studies, such as incorporating more detailed lifeline and building indicators, and developing object-based vulnerability curve assessments of physical vulnerability, for example by defining building material based flood vulnerability curves. Related to this, is the incorporation of time of the day based building occupation patterns (at 2am most people will be at home while at 2pm most people will be in the office). Earthquake assessments could learn from flood studies when it comes to the refined selection of social vulnerability indicators. Based on the lessons obtained in this study, we recommend future studies to further explore cross-hazard studies.

The impact of flooding on people living with HIV: a case study from the Ohangwena Region, Namibia.

PubMed

Anthonj, Carmen; Nkongolo, Odon T; Schmitz, Peter; Hango, Johannes N; Kistemann, Thomas

2015-01-01

Floods are a disaster situation for all affected populations and especially for vulnerable groups within communities such as children, orphans, women, and people with chronic diseases such as HIV and AIDS. They need functioning health care, sanitation and hygiene, safe water, and healthy food supply, and are critically dependent on their social care and support networks. A study carried out in the Ohangwena region, Namibia, where HIV prevalence is high and extensive flooding frequently occurs, aims to provide a deeper understanding of the impact that flooding has on people living with HIV (PLWHIV) as well as on HIV service providers in the region. The qualitative research applying grounded theory included semi-structured interviews with PLWHIV, focus group discussions with HIV service providers, and a national feedback meeting. The findings were interpreted using the sustainable livelihoods framework, the natural hazard research approach, and health behaviour theories. The study reveals that flooding poses major problems to PLWHIV in terms of their everyday lives, affecting livelihoods, work, income, and living conditions. The factors threatening them under normal conditions - poverty, malnutrition, unsafe water, sanitation and hygiene, limited access to health facilities, a weak health status, and stigma - are intensified by flood-related breakdown of infrastructure, insecurity, malnutrition, and diseases evolving over the course of a flood. A potential dual risk exists for their health: the increased risk both of infection and disease due to the inaccessibility of health services and antiretroviral treatment. A HIV and Flooding Framework was developed to display the results. This study demonstrates that vulnerabilities and health risks of PLWHIV will increase in a disaster situation like flooding if access to HIV prevention, treatment, care and support are not addressed and ensured. The findings and the HIV and Flooding Framework are not specific to Ohangwena and can be transferred to any flood-affected region that has a high HIV prevalence and relies mainly on subsistence agriculture. They serve as a model case for analysing vulnerabilities related to health and health service provision under disaster conditions. The impact will vary according to the physical, geographical, climatological, social, and behavioural characteristics of the region and the people affected. In the Ohangwena region, a disaster risk management mechanism is already in place which addresses people with HIV during flooding. However, preparedness could be improved further by applying the HIV and Flooding Framework.

Lack of collagen VI promotes neurodegeneration by impairing autophagy and inducing apoptosis during aging.

PubMed

Cescon, Matilde; Chen, Peiwen; Castagnaro, Silvia; Gregorio, Ilaria; Bonaldo, Paolo

2016-05-01

Collagen VI is an extracellular matrix (ECM) protein with a broad distribution in different tissues and mostly deposited at the close periphery of the cell surface. Previous studies revealed that collagen VI protects neurons from the toxicity of amyloid-βpeptides and from UV-induced damage. However, the physiological role of this protein in the central nervous system (CNS) remains unknown. Here, we established primary neural cultures from murine cortex and hippocampus, and carried out in vitro and in vivo studies in wild-type and collagen VI null (Col6a1-/-) mice. Col6a1-/- neural cultures displayed an increased incidence of spontaneous apoptosis and higher vulnerability to oxidative stress, accompanied by altered regulation of autophagy with increased p62 protein levels and decreased LC3 lipidation. Analysis of brain sections confirmed increased apoptosis and abnormal regulation of autophagy in the CNS of collagen VI-deficient animals. To investigate the in vivo physiological consequences of these CNS defects, we carried out functional studies and found that motor and memory task performances were impaired in aged Col6a1-/-mice. These findings indicate that lack of collagen VI leads to spontaneous apoptosis and defective autophagy in neural cells, and point at a protective role for this ECM protein in the CNS during physiological aging.

Spatial configuration trends in coastal Louisiana from 1985 to 2010

USGS Publications Warehouse

Couvillion, Brady; Fischer, Michelle; Beck, Holly J.; Sleavin, William J.

2016-01-01

From 1932 to 2010, coastal Louisiana has experienced a net loss of 4877 km2 of wetlands. As the area of these wetlands has changed, so too has the spatial configuration of the landscape. The resulting landscape is a mosaic of patches of wetlands and open water. This study examined the spatial and temporal variability of trajectories of landscape configuration and the relation of those patterns to the trajectories of land change in wetlands during a 1985–2010 observation period. Spatial configuration was quantified using multi-temporal satellite imagery and an aggregation index (AI). The results of this analysis indicate that coastal Louisiana experienced a reduction in the AI of coastal wetlands of 1.07 %. In general, forested wetland and fresh marsh types displayed the highest aggregation and stability. The remaining marsh types, (intermediate, brackish, and saline) all experienced disaggregation during the time period, with increasing severity of disaggregation along an increasing salinity gradient. Finally, a correlation (r 2 = 0.5562) was found between AI and the land change rate for the subsequent period, indicating that fragmentation can increase the vulnerability of wetlands to further wetland loss. These results can help identify coastal areas which are susceptible to future wetland loss.

An Integrated Approach for Urban Earthquake Vulnerability Analyses

NASA Astrophysics Data System (ADS)

Düzgün, H. S.; Yücemen, M. S.; Kalaycioglu, H. S.

2009-04-01

The earthquake risk for an urban area has increased over the years due to the increasing complexities in urban environments. The main reasons are the location of major cities in hazard prone areas, growth in urbanization and population and rising wealth measures. In recent years physical examples of these factors are observed through the growing costs of major disasters in urban areas which have stimulated a demand for in-depth evaluation of possible strategies to manage the large scale damaging effects of earthquakes. Understanding and formulation of urban earthquake risk requires consideration of a wide range of risk aspects, which can be handled by developing an integrated approach. In such an integrated approach, an interdisciplinary view should be incorporated into the risk assessment. Risk assessment for an urban area requires prediction of vulnerabilities related to elements at risk in the urban area and integration of individual vulnerability assessments. However, due to complex nature of an urban environment, estimating vulnerabilities and integrating them necessities development of integrated approaches in which vulnerabilities of social, economical, structural (building stock and infrastructure), cultural and historical heritage are estimated for a given urban area over a given time period. In this study an integrated urban earthquake vulnerability assessment framework, which considers vulnerability of urban environment in a holistic manner and performs the vulnerability assessment for the smallest administrative unit, namely at neighborhood scale, is proposed. The main motivation behind this approach is the inability to implement existing vulnerability assessment methodologies for countries like Turkey, where the required data are usually missing or inadequate and decision makers seek for prioritization of their limited resources in risk reduction in the administrative districts from which they are responsible. The methodology integrates socio-economical, structural, coastal, ground condition, organizational vulnerabilities, as well as accessibility to critical services within the framework. The proposed framework has the following eight components: Seismic hazard analysis, soil response analysis, tsunami inundation analysis, structural vulnerability analysis, socio-economic vulnerability analysis, accessibility to critical services, GIS-based integrated vulnerability assessment, and visualization of vulnerabilities in 3D virtual city model The integrated model for various vulnerabilities obtained for the urban area is developed in GIS environment by using individual vulnerability assessments for considered elements at risk and serve for establishing the backbone of the spatial decision support system. The stages followed in the model are: Determination of a common mapping unit for each aspect of urban earthquake vulnerability, formation of a geo-database for the vulnerabilities, evaluation of urban vulnerability based on multi attribute utility theory with various weighting algorithms, mapping of the evaluated integrated earthquake risk in geographic information systems (GIS) in the neighborhood scale. The framework is also applicable to larger geographical mapping scales, for example, the building scale. When illustrating the results in building scale, 3-D visualizations with remote sensing data is used so that decision-makers can easily interpret the outputs. The proposed vulnerability assessment framework is flexible and can easily be applied to urban environments at various geographical scales with different mapping units. The obtained total vulnerability maps for the urban area provide a baseline for the development of risk reduction strategies for the decision makers. Moreover, as several aspects of elements at risk for an urban area is considered through vulnerability analyses, effect on changes in vulnerability conditions on the total can easily be determined. The developed approach also enables decision makers to monitor temporal and spatial changes in the urban environment due to implementation of risk reduction strategies.

Infrastructure effects on estuarine wetlands increase their vulnerability to sea level rise

NASA Astrophysics Data System (ADS)

Rodriguez, Jose; Saco, Patricia; Sandi, Steven; Saintilan, Neil; Riccardi, Gerardo

2017-04-01

At the regional and global scales, coastal management and planning for future sea level rise scenarios is typically supported by modelling tools that predict the expected inundation extent. These tools rely on a number of simplifying assumptions that, in some cases, may result in important miscalculation of the inundation effects. One of such cases is estuarine wetlands, where vegetation strongly depends on both the magnitude and the timing of inundation. Many coastal wetlands display flow restrictions due to infrastructure or drainage works, which produce alterations to the inundation patterns that can not be captured by conventional models. In this contribution we explore the effects of flow restrictions on inundation patterns under sea level rise conditions in estuarine wetlands. We use a spatially-distributed dynamic wetland ecogeomorphological model that not only incorporates the effects of flow restrictions due to culverts, bridges and weirs as well as vegetation, but also considers that vegetation changes as a consequence of increasing inundation. We also consider the ability of vegetation to capture sediment and produce accretion. We apply our model to an estuarine wetland in Australia and show that our model predicts a much faster wetland loss due to sea level rise than conventional approaches.

Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans.

PubMed

Fox, M A; Panessiti, M G; Moya, P R; Tolliver, T J; Chen, K; Shih, J C; Murphy, D L

2013-12-01

A possible side effect of serotonin-enhancing drugs is the serotonin syndrome, which can be lethal. Here we examined possible hypersensitivity to two such drugs, the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) and the atypical opioid tramadol, in mice lacking the genes for both monoamine oxidase A (MAOA) and MAOB. MAOA/B-knockout (KO) mice displayed baseline serotonin syndrome behaviors, and these behavioral responses were highly exaggerated following 5-HTP or tramadol versus baseline and wild-type (WT) littermates. Compared with MAOA/B-WT mice, baseline tissue serotonin levels were increased ∼2.6-3.9-fold in MAOA/B-KO mice. Following 5-HTP, serotonin levels were further increased ∼4.5-6.2-fold in MAOA/B-KO mice. These exaggerated responses are in line with the exaggerated responses following serotonin-enhancing drugs that we previously observed in mice lacking the serotonin transporter (SERT). These findings provide a second genetic mouse model suggestive of possible human vulnerability to the serotonin syndrome in individuals with lesser-expressing MAO or SERT polymorphisms that confer serotonergic system changes.

Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans

PubMed Central

Fox, MA; Panessiti, MG; Moya, PR; Tolliver, TJ; Chen, K; Shih, JC; Murphy, DL

2012-01-01

A possible side effect of serotonin-enhancing drugs is the serotonin syndrome, which can be lethal. Here we examined possible hypersensitivity to two such drugs, the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) and the atypical opioid tramadol, in mice lacking the genes for both monoamine oxidase A (MAOA) and MAOB. MAOA/B-knockout (KO) mice displayed baseline serotonin syndrome behaviors, and these behavioral responses were highly exaggerated following 5-HTP or tramadol versus baseline and wild-type (WT) littermates. Compared with MAOA/B-WT mice, baseline tissue serotonin levels were increased ~2.6–3.9-fold in MAOA/B-KO mice. Following 5-HTP, serotonin levels were further increased ~4.5–6.2-fold in MAOA/B-KO mice. These exaggerated responses are in line with the exaggerated responses following serotonin-enhancing drugs that we previously observed in mice lacking the serotonin transporter (SERT). These findings provide a second genetic mouse model suggestive of possible human vulnerability to the serotonin syndrome in individuals with lesser-expressing MAO or SERT polymorphisms that confer serotonergic system changes. PMID:22964922

The participatory vulnerability scoping diagram - deliberative risk ranking for community water systems

USGS Publications Warehouse

Howe, Peter D.; Yarnal, Brent; Coletti, Alex; Wood, Nathan J.

2013-01-01

Natural hazards and climate change present growing challenges to community water system (CWS) managers, who are increasingly turning to vulnerability assessments to identify, prioritize, and adapt to risks. Effectively assessing CWS vulnerability requires information and participation from various sources, one of which is stakeholders. In this article, we present a deliberative risk-ranking methodology, the participatory vulnerability scoping diagram (P-VSD), which allows rapid assessment and integration of multiple stakeholder perspectives of vulnerability. This technique is based on methods of deliberative risk evaluation and the vulnerability scoping diagram. The goal of the methodology is to engage CWS managers and stakeholders collectively to provide qualitative contextual risk rankings as a first step in a vulnerability assessment. We conduct an initial assessment using a case study of CWS in two U.S. counties, sites with broadly similar exposures but differences in population, land use, and other social sensitivity factors. Results demonstrate that CWS managers and stakeholders in the two case study communities all share the belief that their CWS are vulnerable to hazards but differ in how this vulnerability manifests itself in terms of the exposure, sensitivity, and adaptive capacity of the system.

An Integrated Method to Analyze Farm Vulnerability to Climatic and Economic Variability According to Farm Configurations and Farmers' Adaptations.

PubMed

Martin, Guillaume; Magne, Marie-Angélina; Cristobal, Magali San

2017-01-01

The need to adapt to decrease farm vulnerability to adverse contextual events has been extensively discussed on a theoretical basis. We developed an integrated and operational method to assess farm vulnerability to multiple and interacting contextual changes and explain how this vulnerability can best be reduced according to farm configurations and farmers' technical adaptations over time. Our method considers farm vulnerability as a function of the raw measurements of vulnerability variables (e.g., economic efficiency of production), the slope of the linear regression of these measurements over time, and the residuals of this linear regression. The last two are extracted from linear mixed models considering a random regression coefficient (an intercept common to all farms), a global trend (a slope common to all farms), a random deviation from the general mean for each farm, and a random deviation from the general trend for each farm. Among all possible combinations, the lowest farm vulnerability is obtained through a combination of high values of measurements, a stable or increasing trend and low variability for all vulnerability variables considered. Our method enables relating the measurements, trends and residuals of vulnerability variables to explanatory variables that illustrate farm exposure to climatic and economic variability, initial farm configurations and farmers' technical adaptations over time. We applied our method to 19 cattle (beef, dairy, and mixed) farms over the period 2008-2013. Selected vulnerability variables, i.e., farm productivity and economic efficiency, varied greatly among cattle farms and across years, with means ranging from 43.0 to 270.0 kg protein/ha and 29.4-66.0% efficiency, respectively. No farm had a high level, stable or increasing trend and low residuals for both farm productivity and economic efficiency of production. Thus, the least vulnerable farms represented a compromise among measurement value, trend, and variability of both performances. No specific combination of farmers' practices emerged for reducing cattle farm vulnerability to climatic and economic variability. In the least vulnerable farms, the practices implemented (stocking rate, input use…) were more consistent with the objective of developing the properties targeted (efficiency, robustness…). Our method can be used to support farmers with sector-specific and local insights about most promising farm adaptations.

An Integrated Method to Analyze Farm Vulnerability to Climatic and Economic Variability According to Farm Configurations and Farmers’ Adaptations

PubMed Central

Martin, Guillaume; Magne, Marie-Angélina; Cristobal, Magali San

2017-01-01

The need to adapt to decrease farm vulnerability to adverse contextual events has been extensively discussed on a theoretical basis. We developed an integrated and operational method to assess farm vulnerability to multiple and interacting contextual changes and explain how this vulnerability can best be reduced according to farm configurations and farmers’ technical adaptations over time. Our method considers farm vulnerability as a function of the raw measurements of vulnerability variables (e.g., economic efficiency of production), the slope of the linear regression of these measurements over time, and the residuals of this linear regression. The last two are extracted from linear mixed models considering a random regression coefficient (an intercept common to all farms), a global trend (a slope common to all farms), a random deviation from the general mean for each farm, and a random deviation from the general trend for each farm. Among all possible combinations, the lowest farm vulnerability is obtained through a combination of high values of measurements, a stable or increasing trend and low variability for all vulnerability variables considered. Our method enables relating the measurements, trends and residuals of vulnerability variables to explanatory variables that illustrate farm exposure to climatic and economic variability, initial farm configurations and farmers’ technical adaptations over time. We applied our method to 19 cattle (beef, dairy, and mixed) farms over the period 2008–2013. Selected vulnerability variables, i.e., farm productivity and economic efficiency, varied greatly among cattle farms and across years, with means ranging from 43.0 to 270.0 kg protein/ha and 29.4–66.0% efficiency, respectively. No farm had a high level, stable or increasing trend and low residuals for both farm productivity and economic efficiency of production. Thus, the least vulnerable farms represented a compromise among measurement value, trend, and variability of both performances. No specific combination of farmers’ practices emerged for reducing cattle farm vulnerability to climatic and economic variability. In the least vulnerable farms, the practices implemented (stocking rate, input use…) were more consistent with the objective of developing the properties targeted (efficiency, robustness…). Our method can be used to support farmers with sector-specific and local insights about most promising farm adaptations. PMID:28900435

Accounting for vulnerable populations in rural hazard mitigation plans: results of a survey of emergency managers.

PubMed

Horney, Jennifer A; Nguyen, Mai; Cooper, John; Simon, Matthew; Ricchetti-Masterson, Kristen; Grabich, Shannon; Salvesen, David; Berke, Philip

2013-01-01

Rural areas of the United States are uniquely vulnerable to the impacts of natural disasters. One possible way to mitigate vulnerability to disasters in rural communities is to have a high-quality hazard mitigation plan in place. To understand the resources available for hazard mitigation planning and determine how well hazard mitigation plans in rural counties meet the needs of vulnerable populations, we surveyed the lead planning or emergency management official responsible for hazard mitigation plans in 96 rural counties in eight states in the Southeastern United States. In most counties, emergency management was responsible for implementing the county's hazard mitigation plan and the majority of counties had experienced a presidentially declared disaster in the last 5 years. Our research findings demonstrated that there were differences in subjective measures of vulnerability (as reported by survey respondents) and objective measures of vulnerability (as determined by US Census data). In addition, although few counties surveyed included outreach to vulnerable groups as a part of their hazard mitigation planning process, a majority felt that their hazard mitigation plan addressed the needs of vulnerable populations "well" or "very well." These differences could result in increased vulnerabilities in rural areas, particularly for certain vulnerable groups.

Drought vulnerability assessment: The case of wheat farmers in Western Iran

NASA Astrophysics Data System (ADS)

Zarafshani, Kiumars; Sharafi, Lida; Azadi, Hossein; Hosseininia, Gholamhossein; De Maeyer, Philippe; Witlox, Frank

2012-12-01

Drought, as a natural and slow-onset phenomenon, creates numerous damages to agricultural communities. As a drought prone area in the Middle East, Iran has currently launched a crisis management approach to mitigate the harmful impacts of drought. However, thus far studies indicate that effective drought management strategies should be designed based upon vulnerability management which can increase farmers' ability to challenge the impacts. The purpose of this study was to assess drought vulnerability across three drought intensities (very high, extremely high, and critical) areas in Western Iran. Accordingly, a survey study was applied and 370 wheat farmers who all experienced drought during 2007-2009 were selected through a multi-stage stratified random sampling method. Face to face interviews were used to collect data on vulnerability indices from the farmers. Me-Bar and Valdez's vulnerability formula was applied to assess the vulnerability of wheat farmers during drought. Results revealed that the farmers' vulnerability is influenced mainly by economic, socio-cultural, psychological, technical, and infrastructural factors. The results also indicated that the farmers in Sarpole-Zahab township were most vulnerable compared to those in the Kermanshah township as the least vulnerable. Accordingly, some conclusions and recommendations are drawn for both policy-makers and practitioners who often must prioritize limited resources in the design vulnerability-reducing interventions.

Experimental test of female black howler monkey (Alouatta Pigra) responses to loud calls from potentially infanticidal males: effects of numeric odds, vulnerable offspring, and companion behavior.

PubMed

Kitchen, Dawn M

2006-09-01

During group defense, the contribution of female black howler monkeys (Alouatta pigra) may help deter male intruders; however, their involvement during natural intergroup encounters is facultative. Experimental playback trials simulating potentially infanticidal males were used to examine whether a female's reproductive investment and/or her group's relative fighting ability would influence her participation in loud call displays. Female howlers never responded to recordings without alpha male accompaniment, but their response patterns did not simply mimic his. For example, unlike alpha males, females with small, vulnerable offspring were no more likely than females without infants to participate in howling displays during playback trials. Further, although females without any small infants in their group got closer to speakers than females living in groups with small infants, males did not respond in the same way. To artificially simulate different "numeric odds" scenarios, recordings of one or three howling males (simulated intruders) were broadcast to females living in groups with 1-3 resident males. Responses were consistent with the hypothesis that females assessed intergroup fighting ability. As in alpha males, the weakest female responses occurred when the numeric odds were against their group. However, whereas alpha males participated most when numeric odds were in their favor, females had the most intense approach responses when the number of defending and intruding males was equal. Females appeared to use a cost-effective strategy, reserving their assistance for when their participation could have the greatest impact. 2006 Wiley-Liss, Inc.

A mechanistic hypothesis of the factors that enhance vulnerability to nicotine use in females

PubMed Central

O'Dell, Laura E.; Torres, Oscar V.

2013-01-01

Women are particularly more vulnerable to tobacco use than men. This review proposes a unifying hypothesis that females experience greater rewarding effects of nicotine and more intense stress produced by withdrawal than males. We also provide a neural framework whereby estrogen promotes greater rewarding effects of nicotine in females via enhanced dopamine release in the nucleus accumbens (NAcc). During withdrawal, we suggest that corticotropin-releasing factor (CRF) stress systems are sensitized and promote a greater suppression of dopamine release in the NAcc of females versus males. Taken together, females display enhanced nicotine reward via estrogen and amplified effects of withdrawal via stress systems. Although this framework focuses on sex differences in adult rats, it is also applied to adolescent females who display enhanced rewarding effects of nicotine, but reduced effects of withdrawal from this drug. Since females experience strong rewarding effects of nicotine, a clinical implication of our hypothesis is that specific strategies to prevent smoking initiation among females are critical. Also, anxiolytic medications may be more effective in females that experience intense stress during withdrawal. Furthermore, medications that target withdrawal should not be applied in a unilateral manner across age and sex, given that nicotine withdrawal is lower during adolescence. This review highlights key factors that promote nicotine use in females, and future studies on sex-dependent interactions of stress and reward systems are needed to test our mechanistic hypotheses. Future studies in this area will have important translational value toward reducing health disparities produced by nicotine use in females. PMID:23684991

Modeling Glaucoma: Retinal Ganglion Cells Generated from Induced Pluripotent Stem Cells of Patients with SIX6 Risk Allele Show Developmental Abnormalities.

PubMed

Teotia, Pooja; Van Hook, Matthew J; Wichman, Christopher S; Allingham, R Rand; Hauser, Michael A; Ahmad, Iqbal

2017-11-01

Glaucoma represents a group of multifactorial diseases with a unifying pathology of progressive retinal ganglion cell (RGC) degeneration, causing irreversible vision loss. To test the hypothesis that RGCs are intrinsically vulnerable in glaucoma, we have developed an in vitro model using the SIX6 risk allele carrying glaucoma patient-specific induced pluripotent stem cells (iPSCs) for generating functional RGCs. Here, we demonstrate that the efficiency of RGC generation by SIX6 risk allele iPSCs is significantly lower than iPSCs-derived from healthy, age- and sex-matched controls. The decrease in the number of RGC generation is accompanied by repressed developmental expression of RGC regulatory genes. The SIX6 risk allele RGCs display short and simple neurites, reduced expression of guidance molecules, and immature electrophysiological signature. In addition, these cells have higher expression of glaucoma-associated genes, CDKN2A and CDKN2B, suggesting an early onset of the disease phenotype. Consistent with the developmental abnormalities, the SIX6 risk allele RGCs display global dysregulation of genes which map on developmentally relevant biological processes for RGC differentiation and signaling pathways such as mammalian target of rapamycin that integrate diverse functions for differentiation, metabolism, and survival. The results suggest that SIX6 influences different stages of RGC differentiation and their survival; therefore, alteration in SIX6 function due to the risk allele may lead to cellular and molecular abnormalities. These abnormalities, if carried into adulthood, may make RGCs vulnerable in glaucoma. Stem Cells 2017;35:2239-2252. © 2017 AlphaMed Press.

Developing effective communication materials on the health effects of climate change for vulnerable groups: a mixed methods study.

PubMed

Kreslake, Jennifer M; Price, Katherine M; Sarfaty, Mona

2016-09-07

Individuals with chronic health conditions or low socioeconomic status (SES) are more vulnerable to the health impacts of climate change. Health communication can provide information on the management of these impacts. This study tested, among vulnerable audiences, whether viewing targeted materials increases knowledge about the health impacts of climate change and strength of climate change beliefs, and whether each are associated with stronger intentions to practice recommended behaviors. Low-SES respondents with chronic conditions were recruited for an online survey in six cities. Respondents were shown targeted materials illustrating the relationship between climate change and chronic conditions. Changes in knowledge and climate change beliefs (pre- and post-test) and behavioral intentions (post-test only) were tested using McNemar tests of marginal frequencies of two binary outcomes or paired t-tests, and multivariable linear regression. Qualitative interviews were conducted among target audiences to triangulate survey findings and make recommendations on the design of messages. Respondents (N = 122) reflected the target population regarding income, educational level and prevalence of household health conditions. (1) Knowledge. Significant increases in knowledge were found regarding: groups that are most vulnerable to heat (children [p < 0.001], individuals with heart disease [p < 0.001], or lung disease [p = 0.019]); and environmental conditions that increase allergy-producing pollen (increased heat [p = 0.003], increased carbon dioxide [p < 0.001]). (2) Strength of certainty that climate change is happening increased significantly between pre- and post-test (p < 0.001), as did belief that climate change affected respondents' health (p < 0.001). (3) Behavioral intention. At post-test, higher knowledge of heat vulnerabilities and environmental conditions that trigger pollen allergies were associated with greater behavioral intention scores (p = 0.001 and p = 0.002, respectively). In-depth interviews (N = 15) revealed that vulnerable audiences are interested in immediate-term advice on health management and protective behaviors related to their chronic conditions, but took less notice of messages about collective action to slow or stop climate change. Respondents identified both appealing and less favorable design elements in the materials. Individuals who are vulnerable to the health effects of climate change benefit from communication materials that explain, using graphics and concise language, how climate change affects health conditions and how to engage in protective adaptation behaviors.

Constructing the Indicators of Assessing Human Vulnerability to Industrial Chemical Accidents: A Consensus-based Fuzzy Delphi and Fuzzy AHP Approach.

PubMed

Fatemi, Farin; Ardalan, Ali; Aguirre, Benigno; Mansouri, Nabiollah; Mohammadfam, Iraj

2017-04-10

Industrial chemical accidents have been increased in developing countries. Assessing the human vulnerability in the residents of industrial areas is necessary for reducing the injuries and causalities of chemical hazards. The aim of this study was to explore the key indicators for the assessment of human vulnerability in the residents living near chemical installations. The indicators were established in the present study based on the Fuzzy Delphi method (FDM) and Fuzzy Analytic Hierarchy Process (FAHP). The reliability of FDM and FAHP was calculated. The indicators of human vulnerability were explored in two sets of social and physical domains. Thirty-five relevant experts participated in this study during March-July 2015. According to experts, the top three indicators of human vulnerability according to the FDM and FAHP were vulnerable groups, population density, and awareness. Detailed sub-vulnerable groups and awareness were developed based on age, chronic or severe diseases, disability, first responders, and residents, respectively. Each indicator and sub-indicator was weighted and ranked and had an acceptable consistency ratio. The importance of social vulnerability indicators are about 7 times more than physical vulnerability indicators. Among the extracted indicators, vulnerable groups had the highest weight and the greatest impact on human vulnerability. however, further research is needed to investigate the applicability of established indicators and generalizability of the results to other studies. Fuzzy Delphi; Fuzzy AHP; Human vulnerability; Chemical hazards.

Constructing the Indicators of Assessing Human Vulnerability to Industrial Chemical Accidents: A Consensus-based Fuzzy Delphi and Fuzzy AHP Approach

PubMed Central

Fatemi, Farin; Ardalan, Ali; Aguirre, Benigno; Mansouri, Nabiollah; Mohammadfam, Iraj

2017-01-01

Introduction: Industrial chemical accidents have been increased in developing countries. Assessing the human vulnerability in the residents of industrial areas is necessary for reducing the injuries and causalities of chemical hazards. The aim of this study was to explore the key indicators for the assessment of human vulnerability in the residents living near chemical installations. Methods: The indicators were established in the present study based on the Fuzzy Delphi method (FDM) and Fuzzy Analytic Hierarchy Process (FAHP). The reliability of FDM and FAHP was calculated. The indicators of human vulnerability were explored in two sets of social and physical domains. Thirty-five relevant experts participated in this study during March-July 2015. Results: According to experts, the top three indicators of human vulnerability according to the FDM and FAHP were vulnerable groups, population density, and awareness. Detailed sub-vulnerable groups and awareness were developed based on age, chronic or severe diseases, disability, first responders, and residents, respectively. Each indicator and sub-indicator was weighted and ranked and had an acceptable consistency ratio. Conclusions: The importance of social vulnerability indicators are about 7 times more than physical vulnerability indicators. Among the extracted indicators, vulnerable groups had the highest weight and the greatest impact on human vulnerability. however, further research is needed to investigate the applicability of established indicators and generalizability of the results to other studies. Key words: Fuzzy Delphi; Fuzzy AHP; Human vulnerability; Chemical hazards PMID:28480124

Multiple flood vulnerability assessment approach based on fuzzy comprehensive evaluation method and coordinated development degree model.

PubMed

Yang, Weichao; Xu, Kui; Lian, Jijian; Bin, Lingling; Ma, Chao

2018-05-01

Flood is a serious challenge that increasingly affects the residents as well as policymakers. Flood vulnerability assessment is becoming gradually relevant in the world. The purpose of this study is to develop an approach to reveal the relationship between exposure, sensitivity and adaptive capacity for better flood vulnerability assessment, based on the fuzzy comprehensive evaluation method (FCEM) and coordinated development degree model (CDDM). The approach is organized into three parts: establishment of index system, assessment of exposure, sensitivity and adaptive capacity, and multiple flood vulnerability assessment. Hydrodynamic model and statistical data are employed for the establishment of index system; FCEM is used to evaluate exposure, sensitivity and adaptive capacity; and CDDM is applied to express the relationship of the three components of vulnerability. Six multiple flood vulnerability types and four levels are proposed to assess flood vulnerability from multiple perspectives. Then the approach is applied to assess the spatiality of flood vulnerability in Hainan's eastern area, China. Based on the results of multiple flood vulnerability, a decision-making process for rational allocation of limited resources is proposed and applied to the study area. The study shows that multiple flood vulnerability assessment can evaluate vulnerability more completely, and help decision makers learn more information about making decisions in a more comprehensive way. In summary, this study provides a new way for flood vulnerability assessment and disaster prevention decision. Copyright © 2018 Elsevier Ltd. All rights reserved.

A Population-based Study Evaluating the Association between Surgery in Early Life and Child Development at Primary School Entry.

PubMed

O'Leary, James D; Janus, Magdalena; Duku, Eric; Wijeysundera, Duminda N; To, Teresa; Li, Ping; Maynes, Jason T; Crawford, Mark W

2016-08-01

It is unclear whether exposure to surgery in early life has long-term adverse effects on child development. The authors aimed to investigate whether surgery in early childhood is associated with adverse effects on child development measured at primary school entry. The authors conducted a population-based cohort study in Ontario, Canada, by linking provincial health administrative databases to children's developmental outcomes measured by the Early Development Instrument (EDI). From a cohort of 188,557 children, 28,366 children who underwent surgery before EDI completion (age 5 to 6 yr) were matched to 55,910 unexposed children. The primary outcome was early developmental vulnerability, defined as any domain of the EDI in the lowest tenth percentile of the population. Subgroup analyses were performed based on age at first surgery (less than 2 and greater than or equal to 2 yr) and frequency of surgery. Early developmental vulnerability was increased in the exposed group (7,259/28,366; 25.6%) compared with the unexposed group (13,957/55,910; 25.0%), adjusted odds ratio, 1.05; 95% CI, 1.01 to 1.08. Children aged greater than or equal to 2 yr at the time of first surgery had increased odds of early developmental vulnerability compared with unexposed children (odds ratio, 1.05; 95% CI, 1.01 to 1.10), but children aged less than 2 yr at the time of first exposure were not at increased risk (odds ratio, 1.04; 95% CI, 0.98 to 1.10). There was no increase in odds of early developmental vulnerability with increasing frequency of exposure. Children who undergo surgery before primary school age are at increased risk of early developmental vulnerability, but the magnitude of the difference between exposed and unexposed children is small.

Adolescent Social Isolation as a Model of Heightened Vulnerability to Comorbid Alcoholism and Anxiety Disorders

PubMed Central

Butler, Tracy R.; Karkhanis, Anushree N.; Jones, Sara R.; Weiner, Jeffrey L.

2016-01-01

Individuals diagnosed with anxiety-related illnesses are at increased risk of developing alcoholism, exhibit a telescoped progression of this disease and fare worse in recovery, relative to alcoholics that do not suffer from a comorbid anxiety disorder. Similarly, preclinical evidence supports the notion that stress and anxiety represent major risk factors for the development of alcohol use disorder (AUD). Despite the importance of understanding the link between anxiety and alcoholism, much remains unknown about the neurobiological substrates underlying this relationship. One stumbling block has been the lack of animal models that reliably reproduce the spectrum of behaviors associated with increased vulnerability to these diseases. Here, we review the literature that has examined the behavioral and neurobiological outcomes of a simple rodent adolescent social isolation procedure and discuss its validity as a model of vulnerability to comorbid anxiety disorders and alcoholism. Recent studies have provided strong evidence that adolescent social isolation of male rats leads to the expression of a variety of behaviors linked with increased vulnerability to anxiety and/or AUD, including deficits in sensory gating and fear extinction, and increases in anxiety measures and ethanol drinking. Neurobiological studies are beginning to identify mesolimbic adaptations that may contribute to the behavioral phenotype engendered by this model. Some of these changes include increased excitability of ventral tegmental area dopamine neurons and pyramidal cells in the basolateral amygdala and significant alterations in baseline and stimulated catecholamine signaling. A growing body of evidence suggests that adolescent social isolation may represent a reliable rodent model of heightened vulnerability to anxiety disorders and alcoholism in male rats. These studies provide initial support for the face, construct, and predictive validity of this model and highlight its utility in identifying neurobiological adaptations associated with increased risk of developing these disorders. PMID:27154240

Microbiological Food Safety for Vulnerable People

PubMed Central

Lund, Barbara M.

2015-01-01

Foodborne pathogens are more likely to cause infection and to result in serious consequences in vulnerable people than in healthy adults. People with some increase in susceptibility may form nearly 20% of the population in the UK and the USA. Conditions leading to increased susceptibility are listed. The main factors leading to foodborne disease caused by major pathogens are outlined and examples are given of outbreaks resulting from these factors. Measures to prevent foodborne disease include procedures based on Hazard Analysis Critical Control Point principles and prerequisite programmes and, especially for vulnerable people, the use of lower-risk foods in place of higher-risk products. PMID:26308030

Vulnerability Risk Index Profile for Elder Abuse in Community-Dwelling Population

PubMed Central

Dong, XinQi; Simon, Melissa A.

2013-01-01

Objectives Elder abuse is associated with increased morbidity and mortality. This study aims to develop a vulnerability index for elder abuse in a community-dwelling population. Design Population-based study Setting Geographically defined community in Chicago. Participants A population-based study was conducted in Chicago of community-dwelling older adults who participated in the Chicago Health and Aging Project (CHAP). Of the 8,157 participants in the CHAP study, 213 participants were reported to social services agency for suspected elder abuse. Measurements A vulnerability index for elder abuse was constructed from sociodemographic, health-related, and psychosocial factors. The outcomes of interest were reported and confirmed elder abuse. Logistic regression models were used to determine the accuracy of the index with respect to elder abuse outcomes. Results Out of the selected risk index for elder abuse, every one point increase in the 9 item vulnerability index items, there was a two fold increase in the risk for reported elder abuse (OR, 2.19 (2.00–2.40) and confirmed elder abuse (OR, 2.19 (1.94–2.47). Compared to the reference group, older adults with 3–4 vulnerability index items had increased risk for reported elder abuse (OR, 2.98 (1.98–4.49) and confirmed elder abuse (OR, 3.90, (2.07–7.36); and older adults with 5 or more risk index items, there was an 18 fold increase in risk for reported elder abuse (OR, 18.46 (12.15–28.04) and confirmed elder abuse (OR, 26.79 (14.18–50.61). Receiver Operating Characteristic (ROC) statistically derived curves for identifying reported elder abuse ranged between 0.77–0.84 and for predicting confirmed elder abuse ranged between 0.79–0.86. Conclusion The vulnerability risk index demonstrates value for identifying individuals at risk for elder abuse. Additional studies are needed to validate this index in other community dwelling populations. PMID:25180376

Mapping Extreme Heat Vulnerability and Health Outcomes to inform the District of Columbia's Climate Adaptation Plan

NASA Astrophysics Data System (ADS)

Declet-Barreto, J.; Wilhelmi, O.; Goggans, A.

2016-12-01

In this collaborative engagement, scientists are partnering with the District of Columbia (DC) to develop an extreme heat vulnerability assessment. To do so, we map socio-demographic and built environment indicators of extreme heat vulnerability in Census Tracts in DC neighborhoods. In order to provide information useful for DC public health and urban planning practitioners, we aggregate the indicators into an index of extreme heat vulnerability. We compare the index against heat-related call data from DC's 911 system to better understand the socio-spatial distribution of extreme heat-related health outcomes. Our assessment can help inform the District's Climate Adaptation Plan as well as increase public engagement in reducing vulnerability to extreme heat.

Differential effects of 5-HTTLPR genotypes on mood, memory, and attention bias following acute tryptophan depletion and stress exposure.

PubMed

Firk, Christine; Markus, C Rob

2009-05-01

Polymorphisms of the serotonin transporter gene (5-HTTLPR) may be associated with increased vulnerability to acute tryptophan depletion (ATD) and depression vulnerability especially following stressful life events. The aim of the present study was to investigate the effects of ATD in subjects with different 5-HTTLPR profiles before and after stress exposure on affective and cognitive-attentional changes. Eighteen subjects with homozygotic short alleles (S'/S') and 17 subjects with homozygotic long alleles (L'/L') of the 5-HTTLPR participated in a double-blind, placebo-controlled, crossover design to measure the effects of ATD on mood, memory, and attention before and after acute stress exposure. ATD lowered mood in all subjects independent of genotype. In S'/S' genotypes, mild acute stress increased depressive mood and in L'/L' genotypes increased feelings of vigor. Furthermore, S'/S' genotypes differed from L'/L' genotypes on measures of attention independent of treatment and memory following ATD. Polymorphisms of the 5-HTTLPR differentially affect responses to mild stress and ATD, suggesting greater vulnerability of S'/S' carriers to serotonergic manipulations and supporting increased depression vulnerability.

Social cognition and neurocognition as independent domains in psychosis.

PubMed

van Hooren, S; Versmissen, D; Janssen, I; Myin-Germeys, I; à Campo, J; Mengelers, R; van Os, J; Krabbendam, L

2008-08-01

Patients with psychosis display alterations in social cognition as well as in the realm of neurocognition. It is unclear, however, to what degree these cognitive domains represent two separate dimensions of liability or the pleiotropic expression of a single deficit. The purpose of the present study was to investigate (i) to what extent alterations in social cognition represent an independent area of vulnerability to psychosis, separate from neurocognitive deficits and (ii) whether social cognition is one construct or can be divided into several subcomponents. Five social cognition and three neurocognitive tasks were completed by 186 participants with different levels of vulnerability for psychosis: 44 patients with psychotic disorder; 47 subjects at familial risk; 41 subjects at psychometric risk and 54 control subjects. The social cognition tasks covered important basic subcomponents of social cognition, i.e. mentalisation (or theory of mind), data gathering bias (jumping to conclusions), source monitoring and attribution style. Neurocognitive tasks assessed speed of information processing, inhibition, cognitive shifting and strategy-driven retrieval from semantic memory. The results of factor analysis suggested that neurocognition and social cognition are two separate areas of vulnerability in psychosis. Furthermore, the social cognition measures lacked significant overlap, suggesting a multidimensional construct. Cognitive liabilities to psychosis are manifold, and include key processes underlying basic person-environment interactions in daily life, independent of cognition quantified by neuropsychological tests.

Constructing vulnerabilty and protective measures indices for the enhanced critical infrastructure protection program.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fisher, R. E.; Buehring, W. A.; Whitfield, R. G.

2009-10-14

The US Department of Homeland Security (DHS) has directed its Protective Security Advisors (PSAs) to form partnerships with the owners and operators of assets most essential to the Nation's well being - a subclass of critical infrastructure and key resources (CIKR) - and to conduct site visits for these and other high-risk assets as part of the Enhanced Critical Infrastructure Protection (ECIP) Program. During each such visit, the PSA documents information about the facility's current CIKR protection posture and overall security awareness. The primary goals for ECIP site visits (DHS 2009) are to: (1) inform facility owners and operators ofmore » the importance of their facilities as an identified high-priority CIKR and the need to be vigilant in light of the ever-present threat of terrorism; (2) identify protective measures currently in place at these facilities, provide comparisons of CIKR protection postures across like assets, and track the implementation of new protective measures; and (3) enhance existing relationships among facility owners and operators; DHS; and various Federal, State, local tribal, and territorial partners. PSAs conduct ECIP visits to assess overall site security; educate facility owners and operators about security; help owners and operators identify gaps and potential improvements; and promote communication and information sharing among facility owners and operators, DHS, State governments, and other security partners. Information collected during ECIP visits is used to develop metrics; conduct sector-by-sector and cross-sector vulnerability comparisons; identify security gaps and trends across CIKR sectors and subsectors; establish sector baseline security survey results; and track progress toward improving CIKR security through activities, programs, outreach, and training (Snyder 2009). The data being collected are used in a framework consistent with the National Infrastructure Protection Plan (NIPP) risk criteria (DHS 2009). The NIPP framework incorporates consequence, threat, and vulnerability components and addresses all hazards. The analysis of the vulnerability data needs to be reproducible, support risk analysis, and go beyond protection. It also needs to address important security/vulnerability topics, such as physical security, cyber security, systems analysis, and dependencies and interdependencies. This report provides an overview of the approach being developed to estimate vulnerability and provide vulnerability comparisons for sectors and subsectors. the information will be used to assist DHS in analyzing existing protective measures and vulnerability at facilities, to identify potential ways to reduce vulnerabilities, and to assist in preparing sector risk estimates. The owner/operator receives an analysis of the data collected for a specific asset, showing a comparison between the facility's protection posture/vulnerability index and those of DHS sector/subsector sites visited. This comparison gives the owner/operator an indication of the asset's security strengths and weaknesses that may be contributing factors to its vulnerability and protection posture. The information provided to the owner/operator shows how the asset compares to other similar assets within the asset's sector or subsector. A 'dashboard' display is used to illustrate the results in a convenient format. The dashboard allows the owner/operator to analyze the implementation of additional protective measures and to illustrate how such actions would impact the asset's Protective Measures Index (PMI) or Vulnerability Index (VI).« less

Maternal Separation Enhances Neuronal Activation and Cardiovascular Responses to Acute Stress in Borderline Hypertensive Rats

PubMed Central

Sanders, Brian J.; Anticevic, Alan

2007-01-01

There is much evidence suggesting early life events, such has handling or repeated separations from the nest, can have a long term effect on the biological and behavioral development of rats. The current study examined the effect of repeated maternal separation (MS) on the behavioral, cardiovascular, and neurobiological responses to stress in subjects vulnerable to environmental stressors as adults. Borderline hypertensive rats (BHR), which are the first generation offspring of spontaneously hyperternsive and Wistar-Kyoto rats, were separated from the dams for 3 hours per day from post-natal day 1 through 14. Non-separated controls remained in the home cage. When allowed to explore the open field chamber for 60 minutes as adults, MS subjects had significantly greater locomotor activity compared to controls. All subjects were exposed to 30 minutes of restraint stress during which time mean arterial pressure (MAP) and heart rate (HR) were measured. Although both groups had comparable increases in MAP, MS animals displayed significantly higher HR throughout the stress period. Finally, MS subjects had significantly more stress-induced Fos positive cells, an estimate of neuronal activation, in the central nucleus of the amygdala (CeA), paraventricular nucleus of the hypothalamus (PVN), and the bed nucleus of the stria terminalis (BNST), each of which plays an important role in organizing the biobehavioral response to stress. These results suggest that maternal separation can further enhance stress reactivity in this model and may represent a useful approach for studying the relationship between early life events and future vulnerability to stressful situations. PMID:17604851

Crayfish Self-Administer Amphetamine in a Spatially Contingent Task.

PubMed

Datta, Udita; van Staaden, Moira; Huber, Robert

2018-01-01

Natural reward is an essential element of any organism's ability to adapt to environmental variation. Its underlying circuits and mechanisms guide the learning process as they help associate an event, or cue, with the perception of an outcome's value. More generally, natural reward serves as the fundamental generator of all motivated behavior. Addictive plant alkaloids are able to activate this circuitry in taxa ranging from planaria to humans. With modularly organized nervous systems and confirmed vulnerabilities to human drugs of abuse, crayfish have recently emerged as a compelling model for the study of the addiction cycle, including psychostimulant effects, sensitization, withdrawal, reinstatement, and drug reward in conditioned place preference paradigms. Here we extend this work with the demonstration of a spatially contingent, operant drug self-administration paradigm for amphetamine. When the animal enters a quadrant of the arena with a particular textured substrate, a computer-based control system delivers amphetamine through an indwelling fine-bore cannula. Resulting reward strength, dose-response, and the time course of operant conditioning were assessed. Individuals experiencing the drug contingent on their behavior, displayed enhanced rates of operant responses compared to that of their yoked (non-contingent) counterparts. Application of amphetamine near the supra-esophageal ganglion elicited stronger and more robust increases in operant responding than did systemic infusions. This work demonstrates automated implementation of a spatially contingent self-administration paradigm in crayfish, which provides a powerful tool to explore comparative perspectives in drug-sensitive reward, the mechanisms of learning underlying the addictive cycle, and phylogenetically conserved vulnerabilities to psychostimulant compounds.

Vulnerability and Resilience of the Niger Delta Coastal Communities to Pollution and Environmental Degradation

NASA Astrophysics Data System (ADS)

Ndimele, P. E.; Whenu, O. O.; Anwan, H. R.; Anetekhai, M. A.

2016-02-01

The Niger Delta is Africa's largest delta consisting of the third largest mangrove forest in the world and covering 70,000km2 of Nigeria land mass. This delta is the largest wetland in Africa and among the ten most important wetland and marine ecosystems in the world. The delta is home to all of Nigeria's endemic or near-endemic mammal species and to six IUCN Red List mammals. The Niger Delta harbours globally outstanding fish fauna and displays exceptional evolutionary phenomena with its higher taxonomic endemism and distinct species assemblages. The Niger delta is blessed with abundance of natural and human resources, including the majority of Nigeria's oil and gas deposits, good agricultural land, extensive forests, excellent fisheries as well as a well-developed industrial base, a large labour force and a vibrant private sector. However, this fragile but rich ecosystem is seriously threatened by increased industrial pollution, resource over-exploitation and environmental degradation caused by over six decades of oil exploitation. Aquatic life has been destroyed with the pollution of traditional fishing grounds, exacerbating hunger and poverty in fishing communities. The multifarious use of the delta has led to human-induced changes in biota, habitats and landscapes necessitating the development of a holistic policy that considers all the interacting factors in the ecosystem. Taking a systems approach incorporating an understanding of The Ecosystem Approach, vulnerability, resilience, the DPSIR framework, ecosystem services and societal benefits are integrated in order to evolve a management tool that will result in sustainable resource exploitation, improvement in living standards of locals and restoration of the ecosystem.

Crayfish Self-Administer Amphetamine in a Spatially Contingent Task

PubMed Central

Datta, Udita; van Staaden, Moira; Huber, Robert

2018-01-01

Natural reward is an essential element of any organism’s ability to adapt to environmental variation. Its underlying circuits and mechanisms guide the learning process as they help associate an event, or cue, with the perception of an outcome’s value. More generally, natural reward serves as the fundamental generator of all motivated behavior. Addictive plant alkaloids are able to activate this circuitry in taxa ranging from planaria to humans. With modularly organized nervous systems and confirmed vulnerabilities to human drugs of abuse, crayfish have recently emerged as a compelling model for the study of the addiction cycle, including psychostimulant effects, sensitization, withdrawal, reinstatement, and drug reward in conditioned place preference paradigms. Here we extend this work with the demonstration of a spatially contingent, operant drug self-administration paradigm for amphetamine. When the animal enters a quadrant of the arena with a particular textured substrate, a computer-based control system delivers amphetamine through an indwelling fine-bore cannula. Resulting reward strength, dose-response, and the time course of operant conditioning were assessed. Individuals experiencing the drug contingent on their behavior, displayed enhanced rates of operant responses compared to that of their yoked (non-contingent) counterparts. Application of amphetamine near the supra-esophageal ganglion elicited stronger and more robust increases in operant responding than did systemic infusions. This work demonstrates automated implementation of a spatially contingent self-administration paradigm in crayfish, which provides a powerful tool to explore comparative perspectives in drug-sensitive reward, the mechanisms of learning underlying the addictive cycle, and phylogenetically conserved vulnerabilities to psychostimulant compounds.

A moderate diet restriction during pregnancy alters the levels of endocannabinoids and endocannabinoid-related lipids in the hypothalamus, hippocampus and olfactory bulb of rat offspring in a sex-specific manner

PubMed Central

Ramírez-López, María Teresa; Vázquez, Mariam; Lomazzo, Ermelinda; Hofmann, Clementine; Blanco, Rosario Noemi; Alén, Francisco; Antón, María; Decara, Juan; Arco, Rocío; Orio, Laura; Suárez, Juan; Lutz, Beat; Gómez de Heras, Raquel; Bindila, Laura

2017-01-01

Undernutrition during pregnancy has been associated to increased vulnerability to develop metabolic and behavior alterations later in life. The endocannabinoid system might play an important role in these processes. Therefore, we investigated the effects of a moderate maternal calorie-restricted diet on the levels of the endocannabinoid 2-arachidonoyl glycerol (2-AG), arachidonic acid (AA) and the N-acylethanolamines (NAEs) anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) in the brain of newborn rat offspring. We focused on brain structures involved in metabolism, feeding behavior, as well as emotional and cognitive responses. Female Wistar rats were assigned during the entire pregnancy to either control diet (C) or restriction diet (R), consisting of a 20% calorie-restricted diet. Weight gain and caloric intake of rat dams were monitored and birth outcomes were assessed. 2-AG, AA and NAE levels were measured in hypothalamus, hippocampus and olfactory bulb of the offspring. R dams displayed lower gain weight from the middle pregnancy and consumed less calories during the entire pregnancy. Offspring from R dams were underweight at birth, but litter size was unaffected. In hypothalamus, R male offspring displayed decreased levels of AA and OEA, with no change in the levels of the endocannabinoids 2-AG and AEA. R female exhibited decreased 2-AG and PEA levels. The opposite was found in the hippocampus, where R male displayed increased 2-AG and AA levels, and R female exhibited elevated levels of AEA, AA and PEA. In the olfactory bulb, only R female presented decreased levels of AEA, AA and PEA. Therefore, a moderate diet restriction during the entire pregnancy alters differentially the endocannabinoids and/or endocannabinoid-related lipids in hypothalamus and hippocampus of the underweight offspring, similarly in both sexes, whereas sex-specific alterations occur in the olfactory bulb. Consequently, endocannabinoid and endocannabinoid-related lipid signaling alterations might be involved in the long-term and sexual dimorphism effects commonly observed after undernutrition and low birth weight. PMID:28346523

A moderate diet restriction during pregnancy alters the levels of endocannabinoids and endocannabinoid-related lipids in the hypothalamus, hippocampus and olfactory bulb of rat offspring in a sex-specific manner.

PubMed

Ramírez-López, María Teresa; Vázquez, Mariam; Lomazzo, Ermelinda; Hofmann, Clementine; Blanco, Rosario Noemi; Alén, Francisco; Antón, María; Decara, Juan; Arco, Rocío; Orio, Laura; Suárez, Juan; Lutz, Beat; Gómez de Heras, Raquel; Bindila, Laura; Rodríguez de Fonseca, Fernando

2017-01-01

Undernutrition during pregnancy has been associated to increased vulnerability to develop metabolic and behavior alterations later in life. The endocannabinoid system might play an important role in these processes. Therefore, we investigated the effects of a moderate maternal calorie-restricted diet on the levels of the endocannabinoid 2-arachidonoyl glycerol (2-AG), arachidonic acid (AA) and the N-acylethanolamines (NAEs) anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) in the brain of newborn rat offspring. We focused on brain structures involved in metabolism, feeding behavior, as well as emotional and cognitive responses. Female Wistar rats were assigned during the entire pregnancy to either control diet (C) or restriction diet (R), consisting of a 20% calorie-restricted diet. Weight gain and caloric intake of rat dams were monitored and birth outcomes were assessed. 2-AG, AA and NAE levels were measured in hypothalamus, hippocampus and olfactory bulb of the offspring. R dams displayed lower gain weight from the middle pregnancy and consumed less calories during the entire pregnancy. Offspring from R dams were underweight at birth, but litter size was unaffected. In hypothalamus, R male offspring displayed decreased levels of AA and OEA, with no change in the levels of the endocannabinoids 2-AG and AEA. R female exhibited decreased 2-AG and PEA levels. The opposite was found in the hippocampus, where R male displayed increased 2-AG and AA levels, and R female exhibited elevated levels of AEA, AA and PEA. In the olfactory bulb, only R female presented decreased levels of AEA, AA and PEA. Therefore, a moderate diet restriction during the entire pregnancy alters differentially the endocannabinoids and/or endocannabinoid-related lipids in hypothalamus and hippocampus of the underweight offspring, similarly in both sexes, whereas sex-specific alterations occur in the olfactory bulb. Consequently, endocannabinoid and endocannabinoid-related lipid signaling alterations might be involved in the long-term and sexual dimorphism effects commonly observed after undernutrition and low birth weight.

Carbon pollution increases health inequities: lessons in resilience from the most vulnerable.

PubMed

Ebi, Kristie L; Fawcett, Stephen B; Spiegel, Jerry; Tovalin, Horacio

2016-09-01

Climate change is a social justice as well as an environmental issue. The magnitude and pattern of changes in weather and climate variables are creating differential exposures, vulnerabilities, and health risks that increase stress on health systems while exacerbating existing and creating new health inequities. Examples from national and local health adaptation projects highlight that developing partnerships across sectors and levels are critical for building climate-resilient health systems and communities. Strengthening current and implementing new health interventions, such as using environmental information to develop early warning systems, can be effective in protecting the most vulnerable. However, not all projected risks of climate change can be avoided by climate policies and programs, so health system strengthening is also critical. Applying a health inequity lens can reduce current vulnerabilities while building resilience to longer-term climate change. Taking inequities into account is critical if societies are to effectively prepare for and manage the challenges ahead.

A spatial analysis of population dynamics and climate change in Africa: potential vulnerability hot spots emerge where precipitation declines and demographic pressures coincide

USGS Publications Warehouse

López-Carr, David; Pricope, Narcisa G.; Aukema, Juliann E.; Jankowska, Marta M.; Funk, Christopher C.; Husak, Gregory J.; Michaelsen, Joel C.

2014-01-01

We present an integrative measure of exposure and sensitivity components of vulnerability to climatic and demographic change for the African continent in order to identify “hot spots” of high potential population vulnerability. Getis-Ord Gi* spatial clustering analyses reveal statistically significant locations of spatio-temporal precipitation decline coinciding with high population density and increase. Statistically significant areas are evident, particularly across central, southern, and eastern Africa. The highly populated Lake Victoria basin emerges as a particularly salient hot spot. People located in the regions highlighted in this analysis suffer exceptionally high exposure to negative climate change impacts (as populations increase on lands with decreasing rainfall). Results may help inform further hot spot mapping and related research on demographic vulnerabilities to climate change. Results may also inform more suitable geographical targeting of policy interventions across the continent.

Identifying counties vulnerable to diabetes from obesity prevalence in the United States: a spatiotemporal analysis.

PubMed

Li, Xiao; Staudt, Amanda; Chien, Lung-Chang

2016-11-21

Clinical and epidemiological research has reported a strong association between diabetes and obesity. However, whether increased diabetes prevalence is more likely to appear in areas with increased obesity prevalence has not been thoroughly investigated in the United States (US). The Bayesian structured additive regression model was applied to identify whether counties with higher obesity prevalence are more likely clustered in specific regions in 48 contiguous US states. Prevalence data adopted the small area estimate from the Behavioral Risk Factor Surveillance System. Confounding variables like socioeconomic status adopted data were from the American Community Survey. This study reveals that an increased percentage of relative risk of diabetes was more likely to appear in Southeast, Northeast, Central and South regions. Of counties vulnerable to diabetes, 36.8% had low obesity prevalence, and most of them were located in the Southeast, Central, and South regions. The geographic distribution of counties vulnerable to diabetes expanded to the Southwest, West and Northern regions when obesity prevalence increased. This study also discloses that 7.4% of counties had the largest average in predicted diabetes prevalence compared to the other counties. Their average diabetes prevalence escalated from 8.7% in 2004 to 11.2% in 2011. This study not only identifies counties vulnerable to diabetes due to obesity, but also distinguishes counties in terms of different levels of vulnerability to diabetes. The findings can provide the possibility of establishing targeted surveillance systems to raise awareness of diabetes in those counties.

Wistar-Kyoto rats as an animal model of anxiety vulnerability: support for a hypervigilance hypothesis.

PubMed

McAuley, J D; Stewart, A L; Webber, E S; Cromwell, H C; Servatius, R J; Pang, K C H

2009-12-01

Inbred Wistar-Kyoto (WKY) rats have been proposed as a model of anxiety vulnerability as they display behavioral inhibition and a constellation of learning and reactivity abnormalities relative to outbred Sprague-Dawley (SD) rats. Together, the behaviors of the WKY rat suggest a hypervigilant state that may contribute to its anxiety vulnerability. To test this hypothesis, open-field behavior, acoustic startle, pre-pulse inhibition and timing behavior were assessed in WKY and Sprague-Dawley (SD) rats. Timing behavior was evaluated using a modified version of the peak-interval timing procedure. Training and testing of timing first occurred without audio-visual (AV) interference. Following this initial test, AV interference was included on some trials. Overall, WKY rats took much longer to leave the center of the arena, made fewer line crossings, and reared less, than did SD rats. WKY rats showed much greater startle responses to acoustic stimuli and significantly greater pre-pulse inhibition than did the SD rats. During timing conditions without AV interference, timing accuracy for both strains was similar; peak times for WKY and SD rats were not different. During interference conditions, however, the timing behavior of the two strains was very different. Whereas peak times for SD rats were similar between non-interference and interference conditions, peak times for WKY rats were shorter and response rates higher in interference conditions than in non-interference conditions. The enhanced acoustic startle response, greater prepulse inhibition and altered timing behavior with audio-visual interference supports a characterization of WKY strain as hypervigilant and provides further evidence for the use of the WKY strain as a model of anxiety vulnerability.

Seasonal changes in plant-water relations influence patterns of leaf display in Miombo woodlands: evidence of water conservative strategies.

PubMed

Vinya, Royd; Malhi, Yadvinder; Brown, Nick D; Fisher, Joshua B; Brodribb, Timothy; Aragão, Luiz E O C

2018-06-15

Water availability has frequently been linked to seasonal leaf display in seasonally dry ecosystems, but there have been few ecohydrological investigations of this link. Miombo woodland is a dominant seasonally dry tropical forest ecosystem type in southern Africa; however, there are few data on the relationship between seasonal dynamics in plant-water relations and patterns of leaf display for Miombo woodland. Here we investigate this relationship among nine key Miombo woodland tree species differing in drought tolerance ability and leaf phenology. Results of this study showed that seasonal patterns of leaf phenology varied significantly with seasonal changes in stem water relations among the nine species. Leaf shedding coincided with the attainment of seasonal minimum stem water potential. Leaf flush occurred following xylem rehydration at the peak of the dry season suggesting that endogenous plant factors play a pivotal role in seasonal leaf display in this forest type. Drought-tolerant deciduous species suffered significantly higher seasonal losses in xylem hydraulic conductivity than the drought-intolerant semi-evergreen tree species (P < 0.05). There was a significant and positive correlation between species drought tolerance index and species' seasonal loss in hydraulic conductivity (P < 0.05), confirming the ecological role of long-distance xylem transport in this seasonally dry tropical forest. Our results reveal that water stress in seasonally dry tropical forests selects for water conservative traits that protect the vulnerable xylem transport system. Therefore, seasonal rhythms in xylem transport dictate patterns of leaf display in seasonally dry tropical forests.

[Multidisciplinary guideline 'Recognition and treatment of chronic pain in vulnerable elderly people'].

PubMed

Achterberg, Wilco P; de Ruiter, Corinne M; de Weerd-Spaetgens, Chantal M E E; Geels, Paul; Horikx, Annemieke; Verduijn, Monique M

2012-01-01

Chronic pain in vulnerable elderly people is still poorly recognized and treated, both at home and in hospitals and care and nursing homes. Vulnerable elderly people experience and express pain differently to relatively healthy adults, especially when they suffer from cognitive impairment or specific conditions. Determining the nature and severity of the pain requires the use of pain assessment instruments that have been validated for use in vulnerable elderly people. Effective treatment of pain demands careful diagnosis and pharmacological and non-pharmacological interventions that have proven effectiveness in vulnerable elderly people. The combination of multiple morbidity and poly-pharmacy increases the chance of side-effects and complications. In addition, the pharmacokinetic and pharmacodynamic characteristics of many drugs are different in vulnerable elderly people. The advice is to start with a lower dose of pain medication and gradually build up a level on the basis of pain relief and side-effects ('start low, go slow!').

A user exposure based approach for non-structural road network vulnerability analysis

PubMed Central

Jin, Lei; Wang, Haizhong; Yu, Le; Liu, Lin

2017-01-01

Aiming at the dense urban road network vulnerability without structural negative consequences, this paper proposes a novel non-structural road network vulnerability analysis framework. Three aspects of the framework are mainly described: (i) the rationality of non-structural road network vulnerability, (ii) the metrics for negative consequences accounting for variant road conditions, and (iii) the introduction of a new vulnerability index based on user exposure. Based on the proposed methodology, a case study in the Sioux Falls network which was usually threatened by regular heavy snow during wintertime is detailedly discussed. The vulnerability ranking of links of Sioux Falls network with respect to heavy snow scenario is identified. As a result of non-structural consequences accompanied by conceivable degeneration of network, there are significant increases in generalized travel time costs which are measurements for “emotionally hurt” of topological road network. PMID:29176832

[Research advances in vulnerability assessment of natural ecosystem response to climate change].

PubMed

Zhao, Hui-xia; Wu, Shao-hong; Jiang, Lu-guang

2007-02-01

Climate change with global warming as the sign has been caught great attention by the governments, international organizations, and scientists in the world. Human society and natural ecosystem are both exposed to climate change, and more and more people are waked up by its increasing harm. Vulnerability analysis and assessment are the key and basis for adapting and mitigating climate change, being the highlight in the research fields of climate change and ecology in recent years. The vulnerability assessment of climate change is being carried out in various research fields and on different scales, and much progress has been made. This paper introduced the concept of vulnerability, and summarized the research progress in vulnerability assessment of climate change, with the focus on the frame and methodology of vulnerability assessment of natural ecosystem response to climate change. The existed problems and future prospects in this research area were also discussed.

Maternal effects in vulnerability to eye-parasites and correlations between behavior and parasitism in juvenile Arctic charr.

PubMed

Kortet, Raine; Lautala, Tiina; Kekäläinen, Jukka; Taskinen, Jouni; Hirvonen, Heikki

2017-11-01

Hatchery-reared fish show high mortalities after release to the wild environment. Explanations for this include potentially predetermined genetics, behavioral, and physiological acclimation to fish farm environments, and increased vulnerability to predation and parasitism in the wild. We studied vulnerability to Diplostomum spp. parasites (load of eye flukes in the lenses), immune defense (relative spleen size) and antipredator behaviors (approaches toward predator odor, freezing, and swimming activity) in hatchery-reared juvenile Arctic charr ( Salvelinus alpinus ) using a nested mating design. Fish were exposed to eye-fluke larvae via the incoming water at the hatchery. Fish size was positively associated with parasite load, but we did not find any relationship between relative spleen size and parasitism. The offspring of different females showed significant variation in their parasite load within sires, implying a dam effect in the vulnerability to parasites. However, the family background did not have any effect on spleen size. In the mean sire level over dams, the fish from the bolder (actively swimming) families in the predator trials suffered higher loads of eye flukes than those from more cautiously behaving families. Thus, the results indicate potentially maternally inherited differences in vulnerability to eye-fluke parasites, and that the vulnerability to parasites and behavioral activity are positively associated with each other at the sire level. This could lead to artificial and unintentional selection for increased vulnerability to both parasitism and predation if these traits are favored in fish farm environments.

Transient poverty, poverty dynamics, and vulnerability to poverty: An empirical analysis using a balanced panel from rural China.

PubMed

Ward, Patrick S

2016-02-01

China's economic reforms starting in the late 1970s have resulted in rapid economic growth, with annual growth in gross domestic product averaging greater than 10 percent per year for more than thirty years. Accompanying this rapid growth in national accounts have been rapid and widespread reductions in poverty. With these reductions in poverty, however, there has often been observed an increase in income inequality, both between as well as within rural and urban sectors. This rising income gap challenges the notion that economic reforms in China have been as successful as the poverty statistics would suggest. In this paper, we suggest that an alternative view would be to consider the effects of these reforms on changing the chronic nature of poverty and reducing household vulnerability to poverty. Using a balanced panel from rural China from 1991 through 2006, we find that most poverty among our sample has shifted from being chronic in nature to being transient, with households either shifting into a state of being non-poor moving in and out of poverty. Among our sample, vulnerability to poverty has been declining over time, but the declines are not uniform over time or space. We decompose household vulnerability status into two proximate causes: low expected income and high income variability, finding vulnerability increasingly due to income variability. Additionally, we demonstrate that vulnerable households have very different characteristics than non-vulnerable households.

Transient poverty, poverty dynamics, and vulnerability to poverty: An empirical analysis using a balanced panel from rural China

PubMed Central

Ward, Patrick S.

2015-01-01

China’s economic reforms starting in the late 1970s have resulted in rapid economic growth, with annual growth in gross domestic product averaging greater than 10 percent per year for more than thirty years. Accompanying this rapid growth in national accounts have been rapid and widespread reductions in poverty. With these reductions in poverty, however, there has often been observed an increase in income inequality, both between as well as within rural and urban sectors. This rising income gap challenges the notion that economic reforms in China have been as successful as the poverty statistics would suggest. In this paper, we suggest that an alternative view would be to consider the effects of these reforms on changing the chronic nature of poverty and reducing household vulnerability to poverty. Using a balanced panel from rural China from 1991 through 2006, we find that most poverty among our sample has shifted from being chronic in nature to being transient, with households either shifting into a state of being non-poor moving in and out of poverty. Among our sample, vulnerability to poverty has been declining over time, but the declines are not uniform over time or space. We decompose household vulnerability status into two proximate causes: low expected income and high income variability, finding vulnerability increasingly due to income variability. Additionally, we demonstrate that vulnerable households have very different characteristics than non-vulnerable households. PMID:26855470

Longitudinal modelling of theory-based depressive vulnerabilities, depression trajectories and poor outcomes post-ACS.

PubMed

Keegan, Conor; Conroy, Ronán; Doyle, Frank

2016-02-01

Depression is associated with increased mortality in patients with acute coronary syndrome (ACS). However, little is known about the theoretical causes of depression trajectories post-ACS, and whether these trajectories predict subsequent morbidity/mortality. We tested a longitudinal model of depressive vulnerabilities, trajectories and mortality. A prospective observational study of 374 ACS patients was conducted. Participants completed questionnaires on theoretical vulnerabilities (interpersonal life events, reinforcing events, cognitive distortions, and Type D personality) during hospitalisation and depression at baseline and 3, 6 and 12 months post-hospitalisation. Latent class analysis determined trajectories of depression. Path analysis was used to test relationships among vulnerabilities, depression trajectories and outcomes (combination of 1-year morbidity and 7-year mortality). Vulnerabilities independently predicted persistent and subthreshold depression trajectory categories, with effect sizes significantly highest for persistent depression. Both subthreshold and persistent depression trajectories were significant predictors of morbidity/mortality (e.g. persistent depression OR=2.4, 95% CI=1.8-3.1, relative to never depressed). Causality cannot be inferred from these associations. We had no measures of history of depression or treatments, which may affect associations. Theoretical vulnerabilities predicted depression trajectories, which in turn predicted increased morbidity/mortality, demonstrating for the first time a potential longitudinal chain of events post-ACS. This longitudinal model has important practical implications as clinicians can use vulnerability measures to identify those at most risk of poor outcomes. Copyright © 2015. Published by Elsevier B.V.

Sex differences and emotion regulation: an event-related potential study.

PubMed

Gardener, Elyse K T; Carr, Andrea R; Macgregor, Amy; Felmingham, Kim L

2013-01-01

Difficulties in emotion regulation have been implicated as a potential mechanism underlying anxiety and mood disorders. It is possible that sex differences in emotion regulation may contribute towards the heightened female prevalence for these disorders. Previous fMRI studies of sex differences in emotion regulation have shown mixed results, possibly due to difficulties in discriminating the component processes of early emotional reactivity and emotion regulation. The present study used event-related potentials (ERPs) to examine sex differences in N1 and N2 components (reflecting early emotional reactivity) and P3 and LPP components (reflecting emotion regulation). N1, N2, P3, and LPP were recorded from 20 men and 23 women who were instructed to "increase," "decrease," and "maintain" their emotional response during passive viewing of negative images. Results indicated that women had significantly greater N1 and N2 amplitudes (reflecting early emotional reactivity) to negative stimuli than men, supporting a female negativity bias. LPP amplitudes increased to the "increase" instruction, and women displayed greater LPP amplitudes than men to the "increase" instruction. There were no differences to the "decrease" instruction in women or men. These findings confirm predictions of the female negativity bias hypothesis and suggest that women have greater up-regulation of emotional responses to negative stimuli. This finding is highly significant in light of the female vulnerability for developing anxiety disorders.

Vulnerability to re-entry in simulated two-dimensional cardiac tissue: effects of electrical restitution and stimulation sequence.

PubMed

Tran, Diana X; Yang, Ming-Jim; Weiss, James N; Garfinkel, Alan; Qu, Zhilin

2007-12-01

Ventricular fibrillation is a lethal arrhythmia characterized by multiple wavelets usually starting from a single or figure-of-eight re-entrant circuit. Understanding the factors regulating vulnerability to the re-entry is essential for developing effective therapeutic strategies to prevent ventricular fibrillation. In this study, we investigated how pre-existing tissue heterogeneities and electrical restitution properties affect the initiation of re-entry by premature extrastimuli in two-dimensional cardiac tissue models. We studied two pacing protocols for inducing re-entry following the "sinus" rhythm (S1) beat: (1) a single premature (S2) extrastimulus in heterogeneous tissue; (2) two premature extrastimuli (S2 and S3) in homogeneous tissue. In the first case, the vulnerable window of re-entry is determined by the spatial dimension and extent of the heterogeneity, and is also affected by electrical restitution properties and the location of the premature stimulus. The vulnerable window first increases as the action potential duration (APD) difference between the inside and outside of the heterogeneous region increases, but then decreases as this difference increases further. Steeper APD restitution reduces the vulnerable window of re-entry. In the second case, electrical restitution plays an essential role. When APD restitution is flat, no re-entry can be induced. When APD restitution is steep, re-entry can be induced by an S3 over a range of S1S2 intervals, which is also affected by conduction velocity restitution. When APD restitution is even steeper, the vulnerable window is reduced due to collision of the spiral tips.

A Randomized Trial Evaluating Child Dog-Bite Prevention in Rural China through Video-Based Testimonials

PubMed Central

Shen, Jiabin; Pang, Shulan; Schwebel, David C.

2015-01-01

Objective Dog-bite injuries pose significant threat to children globally. School-aged children are especially at risk because of their cognitively immature tendency toward low perceived vulnerability to bites, and this risk is elevated further for school-aged children living in rural China due to the large number of stray dogs, all potential rabies carriers, present in their communities. Methods This randomized controlled trial evaluated whether viewing an educational video of testimonials would change safety knowledge, perceived vulnerability, and simulated behaviors with dogs among a sample of 280 third and fourth graders living in rural China. Participants were randomly assigned to view either an educational video of testimonials on dog-bite prevention (treatment) or an educational video of testimonials on drowning prevention (comparison). Safety knowledge, perceived vulnerability to dog bites, and simulated behavior with dogs using a dollhouse model were assessed both before and after exposure to the video of testimonials. Results Children who watched the educational video of testimonials on dog-bite prevention had increased safety knowledge, higher perceived vulnerability, and less risky simulated behaviors with dogs compared to the comparison group. Mediation analysis revealed that the intervention successfully changed children's simulated behaviors with dogs through greater safety knowledge and increased perceived vulnerability. Conclusions Results suggest the incorporation of testimonials into injury prevention programs has potential for broad global dissemination. The fact that both increased knowledge and heightened perceived vulnerability mediated changes in simulated behavior suggests the dual roles of knowledge and appraisal on children's injury-risk behavior. PMID:26523353

A randomized trial evaluating child dog-bite prevention in rural China through video-based testimonials.

PubMed

Shen, Jiabin; Pang, Shulan; Schwebel, David C

2016-05-01

Dog-bite injuries pose significant threat to children globally. School-age children are especially at risk because of their insufficient safety knowledge and cognitively immature tendency toward low perceived vulnerability to bites, and this risk is elevated further for school-age children living in rural China due to the large number of stray dogs, all potential rabies carriers, present in their communities. This randomized controlled trial evaluated whether viewing an educational video of testimonials would change safety knowledge, perceived vulnerability, and simulated behaviors with dogs among a sample of 280 third and fourth graders living in rural China. Participants were randomly assigned to view either an educational video of testimonials on dog-bite prevention (treatment) or an educational video of testimonials on drowning prevention (comparison). Safety knowledge, perceived vulnerability to dog bites, and simulated behavior with dogs using a dollhouse model were assessed both before and after exposure to the video of testimonials. Children who watched the educational video of testimonials on dog-bite prevention had increased safety knowledge, higher perceived vulnerability, and less risky simulated behaviors with dogs compared with the comparison group. Mediation analysis revealed that the intervention successfully changed children's simulated behaviors with dogs through greater safety knowledge and increased perceived vulnerability. Results suggest the incorporation of testimonials into injury prevention programs has potential for broad global dissemination. The fact that both increased knowledge and heightened perceived vulnerability mediated changes in simulated behavior suggests the dual roles of knowledge and appraisal on children's injury-risk behavior. (c) 2016 APA, all rights reserved).

Phenotypic vulnerability of energy balance responses to sleep loss in healthy adults

PubMed Central

Spaeth, Andrea M.; Dinges, David F.; Goel, Namni

2015-01-01

Short sleep duration is a risk factor for increased hunger and caloric intake, late-night eating, attenuated fat loss when dieting, and for weight gain and obesity. It is unknown whether altered energy-balance responses to sleep loss are stable (phenotypic) over time, and the extent to which individuals differ in vulnerability to such responses. Healthy adults experienced two laboratory exposures to sleep restriction separated by 60–2132 days. Caloric intake, meal timing and weight were objectively measured. Although there were substantial phenotypic differences among participants in weight gain, increased caloric intake, and late-night eating and fat intake, responses within participants showed stability across sleep restriction exposures. Weight change was consistent in both normal-weight and overweight adults. Weight change and increased caloric intake were more stable in men whereas late-night eating was consistent in both genders. This is the first evidence of phenotypic differential vulnerability and trait-like stability of energy balance responses to repeated sleep restriction, underscoring the need for biomarkers and countermeasures to predict and mitigate this vulnerability. PMID:26446681

Building human resilience: the role of public health preparedness and response as an adaptation to climate change.

PubMed

Keim, Mark E

2008-11-01

Global climate change will increase the probability of extreme weather events, including heatwaves, drought, wildfire, cyclones, and heavy precipitation that could cause floods and landslides. Such events create significant public health needs that can exceed local capacity to respond, resulting in excess morbidity or mortality and in the declaration of disasters. Human vulnerability to any disaster is a complex phenomenon with social, economic, health, and cultural dimensions. Vulnerability to natural disasters has two sides: the degree of exposure to dangerous hazards (susceptibility) and the capacity to cope with or recover from disaster consequences (resilience). Vulnerability reduction programs reduce susceptibility and increase resilience. Susceptibility to disasters is reduced largely by prevention and mitigation of emergencies. Emergency preparedness and response and recovery activities--including those that address climate change--increase disaster resilience. Because adaptation must occur at the community level, local public health agencies are uniquely placed to build human resilience to climate-related disasters. This article discusses the role of public health in reducing human vulnerability to climate change within the context of select examples for emergency preparedness and response.

Phenotypic vulnerability of energy balance responses to sleep loss in healthy adults.

PubMed

Spaeth, Andrea M; Dinges, David F; Goel, Namni

2015-10-08

Short sleep duration is a risk factor for increased hunger and caloric intake, late-night eating, attenuated fat loss when dieting, and for weight gain and obesity. It is unknown whether altered energy-balance responses to sleep loss are stable (phenotypic) over time, and the extent to which individuals differ in vulnerability to such responses. Healthy adults experienced two laboratory exposures to sleep restriction separated by 60-2132 days. Caloric intake, meal timing and weight were objectively measured. Although there were substantial phenotypic differences among participants in weight gain, increased caloric intake, and late-night eating and fat intake, responses within participants showed stability across sleep restriction exposures. Weight change was consistent in both normal-weight and overweight adults. Weight change and increased caloric intake were more stable in men whereas late-night eating was consistent in both genders. This is the first evidence of phenotypic differential vulnerability and trait-like stability of energy balance responses to repeated sleep restriction, underscoring the need for biomarkers and countermeasures to predict and mitigate this vulnerability.

Oligodendroglia are particularly vulnerable to oxidative damage after neurotrauma in vivo.

PubMed

Giacci, Marcus K; Bartlett, Carole A; Smith, Nicole M; Iyer, K Swaminathan; Toomey, Lillian M; Jiang, Haibo; Guagliardo, Paul; Kilburn, Matt R; Fitzgerald, Melinda

2018-06-18

Loss of function following injury to the central nervous system is worsened by secondary degeneration of neurons and glia surrounding the injury and initiated by oxidative damage. However, it is not yet known which cellular populations and structures are most vulnerable to oxidative damage in vivo Using Nanoscale secondary ion mass spectrometry (NanoSIMS), oxidative damage was semi-quantified within cellular subpopulations and structures of optic nerve vulnerable to secondary degeneration, following a partial transection of the optic nerve in adult female PVG rats. Simultaneous assessment of cellular subpopulations and structures revealed oligodendroglia as the most vulnerable to DNA oxidation following injury. 5-ethynyl-2'-deoxyuridine (EdU) was used to label cells that proliferated in the first 3 days after injury. Injury led to increases in DNA, protein and lipid damage in OPCs and mature oligodendrocytes at 3 days, regardless of proliferative state, associated with a decline in the numbers of OPCs at 7 days. O4+ pre-oligodendrocytes also exhibited increased lipid peroxidation. Interestingly, EdU+ mature oligodendrocytes derived after injury demonstrated increased early susceptibility to DNA damage and lipid peroxidation. However, EdU- mature oligodendrocytes with high 8OHdG immunoreactivity were more likely to be caspase3+. By day 28, newly derived mature oligodendrocytes had significantly reduced MYRF mRNA indicating that the myelination potential of these cells may be reduced. The proportion of caspase3+ oligodendrocytes remained higher in EdU- cells. Innovative use of NanoSIMS together with traditional immunohistochemistry and in situ hybridisation have enabled the first demonstration of subpopulation specific oligodendroglial vulnerability to oxidative damage, due to secondary degeneration in vivo. SIGNIFICANCE STATEMENT Injury to the central nervous system is characterised by oxidative damage in areas adjacent to the injury. However, the cellular subpopulations and structures most vulnerable to this damage remain to be elucidated. Here we use powerful NanoSIMS techniques to show increased oxidative damage in oligodendroglia and axons and to demonstrate that cells early in the oligodendroglial lineage are the most vulnerable to DNA oxidation. Further immunohistochemical and in situ hybridisation investigation reveals that mature oligodendrocytes derived after injury are more vulnerable to oxidative damage than their counterparts existing at the time of injury and have reduced MYRF mRNA, yet pre-existing oligodendrocytes are more likely to die. Copyright © 2018 the authors.

Linking local vulnerability to climatic hazard damage assessment for integrated river basin management

NASA Astrophysics Data System (ADS)

Hung, Hung-Chih; Liu, Yi-Chung; Chien, Sung-Ying

2015-04-01

1. Background Major portions of areas in Asia are expected to increase exposure and vulnerability to climate change and weather extremes due to rapid urbanization and overdevelopment in hazard-prone areas. To prepare and confront the potential impacts of climate change and related hazard risk, many countries have implemented programs of integrated river basin management. This has led to an impending challenge for the police-makers in many developing countries to build effective mechanism to assess how the vulnerability distributes over river basins, and to understand how the local vulnerability links to climatic (climate-related) hazard damages and risks. However, the related studies have received relatively little attention. This study aims to examine whether geographic localities characterized by high vulnerability experience significantly more damages owing to onset weather extreme events at the river basin level, and to explain what vulnerability factors influence these damages or losses. 2. Methods and data An indicator-based assessment framework is constructed with the goal of identifying composite indicators (including exposure, biophysical, socioeconomic, land-use and adaptive capacity factors) that could serve as proxies for attributes of local vulnerability. This framework is applied by combining geographical information system (GIS) techniques with multicriteria decision analysis (MCDA) to evaluate and map integrated vulnerability to climatic hazards across river basins. Furthermore, to explain the relationship between vulnerability factors and disaster damages, we develop a disaster damage model (DDM) based on existing disaster impact theory. We then synthesize a Zero-Inflated Poisson regression model with a Tobit regression analysis to identify and examine how the disaster impacts and vulnerability factors connect to typhoon disaster damages and losses. To illustrate the proposed methodology, the study collects data on the vulnerability attributes of the Kaoping, Tsengwen, and Taimali River basins in southern Taiwan, and on the disaster impacts and damages in these river basins due to Typhoon Morakot in 2009. The data was offered by the National Science and Technology Center for Disaster Reduction, Taiwan, as well as collected from the National Land Use Investigation, official census statistics and questionnaire surveys. 3. Results We use an MCDA to create a composite vulnerability index, and this index is incorporated into a GIS analysis to demonstrate the results of integrated vulnerability assessment throughout the river basins. Results of the vulnerability assessment indicate that the most vulnerable areas are almost all situated in the regions of middle and upper reaches of the river basins. Through the examining of DDM, it shows that the vulnerability factors play a critical role in determining disaster damages. Findings also present that the losses and casualties caused by Typhoon Morakot increase with elevation, urban and agricultural developments, proximity to rivers, and decrease with levels of income and adaptive capacity. Finally, we propose the adaptive options for minimizing vulnerability and risk, as well as for integrated river basin governance.

Vulnerability assessment in a participatory approach to design and implement community based adaptation to drought in the Peruvian Andes

NASA Astrophysics Data System (ADS)

Lasage, Ralph; Muis, Sanne; Sardella, Carolina; van Drunen, Michiel; Verburg, Peter; Aerts, Jeroen

2015-04-01

The livelihoods of people in the Andes are expected to be affected by climate change due to their dependence on glacier meltwater during the growing season. The observed decrease in glacier volume over the last few decades is likely to accelerate during the current century, which will affect water availability in the region. This paper presents the implementation of an approach for the participatory development of community-based adaptation measures to cope with the projected impacts of climate change, which was implemented jointly by the local community and by a team consisting of an NGO, Peruvian ministry of environment, research organisations and a private sector organisation. It bases participatory design on physical measurements, modelling and a vulnerability analysis. Vulnerability to drought is made operational for households in a catchment of the Ocoña river basin in Peru. On the basis of a household survey we explore how a vulnerability index (impacts divided by the households' perceived adaptive capacity) can be used to assess the distribution of vulnerability over households in a sub catchment. The socio-economic factors water entitlement, area of irrigated land, income and education are all significantly correlate with this vulnerability to drought. The index proved to be appropriate for communicating about vulnerability to climate change and its determining factors with different stakeholders. The water system research showed that the main source of spring water is local rainwater, and that water use efficiency in farming is low. The adaptation measures that were jointly selected by the communities and the project team aimed to increase water availability close to farmland, and increase water use efficiency, and these will help to reduce the communities vulnerability to drought.

Food web structure and interaction strength pave the way for vulnerability to extinction.

PubMed

Karlsson, Patrik; Jonsson, Tomas; Jonsson, Annie

2007-11-07

This paper focuses on how food web structure and interactions among species affects the vulnerability, due to environmental variability, to extinction of species at different positions in model food webs. Vulnerability is here not measured by a traditional extinction threshold but is instead inspired by the IUCN criteria for endangered species: an observed rapid decline in population abundance. Using model webs influenced by stochasticity with zero autocorrelation, we investigate the ecological determinants of species vulnerability, i.e. the trophic interactions between species and food web structure and how these interact with the risk of sudden drops in abundance of species. We find that (i) producers fulfil the criterion of vulnerable species more frequently than other species, (ii) food web structure is related to vulnerability, and (iii) the vulnerability of species is greater when involved in a strong trophic interaction than when not. We note that our result on the relationship between extinction risk and trophic position of species contradict previous suggestions and argue that the main reason for the discrepancy probably is due to the fact that we study the vulnerability to environmental stochasticity and not extinction risk due to overexploitation, habitat destruction or interactions with introduced species. Thus, we suggest that the vulnerability of species to environmental stochasticity may be differently related to trophic position than the vulnerability of species to other factors. Earlier research on species extinctions has looked for intrinsic traits of species that correlate with increased vulnerability to extinction. However, to fully understand the extinction process we must also consider that species interactions may affect vulnerability and that not all extinctions are the result of long, gradual reductions in species abundances. Under environmental stochasticity (which importance frequently is assumed to increase as a result of climate change) and direct and indirect interactions with other species some extinctions may occur rapidly and apparently unexpectedly. To identify the first declines of population abundances that may escalate and lead to extinctions as early as possible, we need to recognize which species are at greatest risk of entering such dangerous routes and under what circumstances. This new perspective may contribute to our understanding of the processes leading to extinction of populations and eventually species. This is especially urgent in the light of the current biodiversity crisis where a large fraction of the world's biodiversity is threatened.

Limits to physiological plasticity of the coral Pocillopora verrucosa from the central Red Sea

NASA Astrophysics Data System (ADS)

Ziegler, Maren; Roder, Cornelia M.; Büchel, Claudia; Voolstra, Christian R.

2014-12-01

Many coral species display changing distribution patterns across coral reef depths. While changes in the underwater light field and the ability to associate with different photosynthetic symbionts of the genus Symbiodinium explain some of the variation, the limits to physiological plasticity are unknown for most corals. In the central Red Sea, colonies of the branching coral Pocillopora verrucosa are most abundant in shallow high light environments and become less abundant in water depths below 10 m. To further understand what determines this narrow distribution, we conducted a cross-depths transplant experiment looking at physiological plasticity and acclimation in regard to depth. Colonies from 5, 10, and 20 m were collected, transplanted to all depths, and re-investigated after 30 and 210 d. All coral colonies transplanted downward from shallow to deep water displayed an increase in photosynthetic light-harvesting pigments, which resulted in higher photosynthetic efficiency. Shallow-water specimens transplanted to deeper water showed a significant decrease in total protein content after 30 and 210 d under low light conditions compared to specimens transplanted to shallow and medium depths. Stable isotope data suggest that heterotrophic input of carbon was not increased under low light, and consequently, decreasing protein levels were symptomatic of decreasing photosynthetic rates that could not be compensated for through higher light-harvesting efficiency. Our results provide insights into the physiological plasticity of P. verrucosa in changing light regimes and explain the observed depth distribution pattern. Despite its high abundance in shallow reef waters, P. verrucosa possesses limited heterotrophic acclimation potential, i.e., the ability to support its mainly photoautotrophic diet through heterotrophic feeding. We conclude that P. verrucosa might be a species vulnerable to sudden changes in underwater light fields resulting from processes such as increased turbidity caused by coastal development along the Saudi Arabian Red Sea coast.

Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior.

PubMed

Ruan, Chun-Sheng; Yang, Chun-Rui; Li, Jia-Yi; Luo, Hai-Yun; Bobrovskaya, Larisa; Zhou, Xin-Fu

2016-07-01

Exposure to stressful life events plays a central role in the development of mood disorders in vulnerable individuals. However, the mechanisms that link mood disorders to stress are poorly understood. Brain-derived neurotrophic factor (BDNF) has long been implicated in positive regulation of depression and anxiety, while its precursor (proBDNF) recently showed an opposing effect on such mental illnesses. P75(NTR) and sortilin are co-receptors of proBDNF, however, the role of these receptors in mood regulation is not established. Here, we aimed to investigate the role of sortilin in regulating mood-related behaviors and its role in the proBDNF-mediated mood abnormality in mice. We found that sortilin was up-regulated in neocortex (by 78.3%) and hippocampus (by 111%) of chronically stressed mice as assessed by western blot analysis. These changes were associated with decreased mobility in the open field test and increased depression-like behavior in the forced swimming test. We also found that sortilin deficiency in mice resulted in hyperlocomotion in the open field test and increased anxiety-like behavior in both the open field and elevated plus maze tests. No depression-like behavior in the forced swimming test and no deficit in spatial cognition in the Morris water maze test were found in the Sort1-deficient mice. Moreover, the intracellular and extracellular levels of mature BDNF and proBDNF were not changed when sortilin was absent in vivo and in vitro. Finally, we found that both WT and Sort1-deficient mice injected with proBDNF in lateral ventricle displayed increased depression-like behavior in the forced swimming test but not anxiety-like behaviors in the open field and elevated plus maze tests. The present study suggests that sortilin functions as a negative regulator of mood performance and can be a therapeutic target for the treatment of mental illness. Crown Copyright © 2016. Published by Elsevier Inc. All rights reserved.

Modelling homogeneous regions of social vulnerability to malaria in Rwanda.

PubMed

Bizimana, Jean Pierre; Kienberger, Stefan; Hagenlocher, Michael; Twarabamenye, Emmanuel

2016-03-31

Despite the decline in malaria incidence due to intense interventions, potentials for malaria transmission persist in Rwanda. To eradicate malaria in Rwanda, strategies need to expand beyond approaches that focus solely on malaria epidemiology and also consider the socioeconomic, demographic and biological/disease-related factors that determine the vulnerability of potentially exposed populations. This paper analyses current levels of social vulnerability to malaria in Rwanda by integrating a set of weighted vulnerability indicators. The paper uses regionalisation techniques as a spatially explicit approach for delineating homogeneous regions of social vulnerability to malaria. This overcomes the limitations of administrative boundaries for modelling the trans-boundary social vulnerability to malaria. The utilised approach revealed high levels of social vulnerability to malaria in the highland areas of Rwanda, as well as in remote areas where populations are more susceptible. Susceptibility may be due to the populations' lacking the capacity to anticipate mosquito bites, or lacking resilience to cope with or recover from malaria infection. By highlighting the most influential indicators of social vulnerability to malaria, the applied approach indicates which vulnerability domains need to be addressed, and where appropriate interventions are most required. Interventions to improve the socioeconomic development in highly vulnerable areas could prove highly effective, and provide sustainable outcomes against malaria in Rwanda. This would ultimately increase the resilience of the population and their capacity to better anticipate, cope with, and recover from possible infection.

Determinants of physician utilization, emergency room use, and hospitalizations among populations with multiple health vulnerabilities.

PubMed

Small, La Fleur F

2011-09-01

Understanding the factors that influence differing types of health care utilization within vulnerable groups can serve as a basis for projecting future health care needs, forecasting future health care expenditures, and influencing social policy. In this article the Behavioral Model for Vulnerable Populations is used to evaluate discretionary (physician visits) and non-discretionary (emergency room visits, and hospitalizations) health utilization patterns of a sample of 1466 respondents with one or more vulnerable health classification. Reported vulnerabilities include: (1) persons with substance disorders; (2) homeless persons; (3) persons with mental health problems; (4) victims of violent crime; (5) persons diagnosed with HIV/AIDS; (6) and persons in receipt of public benefits. Hierarchical logistic regression is used on three nested models to model factors that influence physician visits, emergency room visits, and hospitalizations. Additionally, bivariate logistic regression analyses are completed using a vulnerability index to evaluate the impact of increased numbers of vulnerability on all three forms of health care utilization. Findings from this study suggest the Behavioral Model of Vulnerable Populations be employed in future research regarding health care utilization patterns among vulnerable populations. This article encourages further research investigating the cumulative effect of health vulnerabilities on the use of non-discretionary services so that this behavior could be better understood and appropriate social policies and behavioral interventions implemented.

On the Science-Policy Bridge: Do Spatial Heat Vulnerability Assessment Studies Influence Policy?

PubMed

Wolf, Tanja; Chuang, Wen-Ching; McGregor, Glenn

2015-10-23

Human vulnerability to heat varies at a range of spatial scales, especially within cities where there can be noticeable intra-urban differences in heat risk factors. Mapping and visualizing intra-urban heat vulnerability offers opportunities for presenting information to support decision-making. For example the visualization of the spatial variation of heat vulnerability has the potential to enable local governments to identify hot spots of vulnerability and allocate resources and increase assistance to people in areas of greatest need. Recently there has been a proliferation of heat vulnerability mapping studies, all of which, to varying degrees, justify the process of vulnerability mapping in a policy context. However, to date, there has not been a systematic review of the extent to which the results of vulnerability mapping studies have been applied in decision-making. Accordingly we undertook a comprehensive review of 37 recently published papers that use geospatial techniques for assessing human vulnerability to heat. In addition, we conducted an anonymous survey of the lead authors of the 37 papers in order to establish the level of interaction between the researchers as science information producers and local authorities as information users. Both paper review and author survey results show that heat vulnerability mapping has been used in an attempt to communicate policy recommendations, raise awareness and induce institutional networking and learning, but has not as yet had a substantive influence on policymaking or preventive action.

[Effect of alcohol intake on the ability to pilot aircraft].

PubMed

Ushakov, I B; Egorov, S V

1996-01-01

During the initial 4 hours after alcohol intake at a dose of 1.9 g/kg aircraft operators displayed disturbances in the psychic processes and functions responsible for each (from information reception and processing up to decision-making and building-up the controlling actions) structural elements in their activity resulting in considerable limitation or a complete failure to pilot aircraft. Main disorders included inability to correctly analyse flight situation and loss of skills to automatically control simulator, a sudden depletion of psychophysiological reserves and deterioration of operator's reliability. Less elaborated professional skills appear to be the most vulnerable.

Assessment of groundwater vulnerability in the coastal region of Oman using DRASTIC index method in GIS environment.

PubMed

Jamrah, Ahmad; Al-Futaisi, Ahmed; Rajmohan, Natarajan; Al-Yaroubi, Saif

2008-12-01

A study was carried out to develop a vulnerability map for Barka region in the North Batina of Oman using DRASTIC vulnerability index method in GIS environment. DRASTIC layers were created using data from published reports and the seven DRASTIC layers were processed by the ArcGIS geographic information system. Finally, DRASTIC maps were created for 1995 and 2004 to understand the long-term changes in the vulnerability index. DRASTIC vulnerability maps were evaluated using groundwater quality data such as chemical and biological parameters. DRASTIC vulnerability maps of 1995 and 2004 indicate that the northern part of Barka is more vulnerable to pollution than southern part and the central part of Barka also shows high relative vulnerability which is mostly related to the high conductivity values. Moreover, the changes in water level due to high abstraction rate of groundwater reflect in the vulnerability maps and low vulnerability area is increased in the southern part during 2004 compared to 1995. Moreover, regional distribution maps of nitrate, chloride and total and fecal coliforms are well correlated with DRASTIC vulnerability maps. In contrast to this, even though DRASTIC method predicted the central part of the study region is highly vulnerable, both chemical and biological parameters show lower concentrations in this region compared to coastal belt, which is mainly due to agricultural and urban development. In Barka, urban development and agricultural activities are very high in coastal region compared to southern and central part of the study area. Hence, this study concluded that DRASTIC method is also applicable in coastal region having ubiquitous contamination sources.

Vulnerability assessment including tangible and intangible components in the index composition: An Amazon case study of flooding and flash flooding.

PubMed

Andrade, Milena Marília Nogueira de; Szlafsztein, Claudio Fabian

2018-07-15

The vulnerability of cities and communities in the Amazon to flooding and flash flooding is increasing. The effects of extreme events on populations vary across landscapes, causing vulnerability to differ spatially. Traditional vulnerability studies in Brazil and across the world have used the vulnerability index for the country and, more recently, municipality scales. The vulnerability dimensions are exposure, sensitivity, and adaptive capacity. For each of these dimensions, there is a group of indicators that constitutes a vulnerability index using quantitative data. Several vulnerability assessments have used sensitivity and exposure analyses and, recently, adaptive capacity has been considered. The Geographical Information Systems (GIS) analysis allows spatial regional modeling using quantitative vulnerability indicators. This paper presents a local-scale vulnerability assessment in an urban Amazonian area, Santarém City, using interdisciplinary methods. Data for exposure and sensitivity were gathered by remote sensing and census data, respectively. However, adaptive capacity refers to local capacities, whether infrastructural or not, and the latter were gathered by qualitative participatory methods. For the mixed data used to study adaptive capacity, we consider tangible components for countable infrastructure that can cope with hazards, and intangible components that reflect social activities based on risk perceptions and collective action. The results indicate that over 80% of the area is highly or moderately vulnerable to flooding and flash flooding. Exposure and adaptive capacity were determinants of the results. Lower values of adaptive capacity play a significant role in vulnerability enhancement. Copyright © 2018 Elsevier B.V. All rights reserved.

The ethics and regulatory landscape of including vulnerable populations in pragmatic clinical trials

PubMed Central

Welch, Mary Jane; Lally, Rachel; Miller, Jennifer E; Pittman, Stephanie; Brodsky, Lynda; Caplan, Arthur L; Uhlenbrauck, Gina; Louzao, Darcy M; Fischer, James H; Wilfond, Benjamin

2015-01-01

Policies have been developed to protect vulnerable populations in clinical research, particularly the US federal research regulations (45 CFR 46 subparts B, C, and D). These policies generally recognize vulnerable populations to include pregnant women, fetuses, neonates, children, prisoners, persons with physical handicaps or mental disabilities, and disadvantaged persons. The aim has been to protect these populations from harm, often by creating regulatory and ethical checks that may limit their participation in many clinical trials. The recent increase in pragmatic clinical trials (PCTs) raises at least two questions about this approach. First, is exclusion itself a harm to vulnerable populations, as these groups may be denied access to understanding how health interventions work for them in clinical settings? Second, are groups considered vulnerable in traditional clinical trials also vulnerable in PCTs? We argue first, that excluding vulnerable subjects from participation in PCTs can be harmful by preventing acquisition of data to meaningfully inform clinical decision-making in the future. Second, we argue that protections for vulnerable subjects in traditional clinical trial settings may not be translatable, feasible, or even ethical to apply in PCTs. We conclude by offering specific recommendations for appropriately protecting vulnerable research subjects in PCTs, focusing on pregnant women, fetuses, neonates, children, prisoners, persons with physical handicaps or mental disabilities, and disadvantaged persons. PMID:26374681

[Local conditions of vulnerability associated with dengue in two communities of Morelos].

PubMed

Chuc, Silvia; Hurtado-Díaz, Magali; Schilmann, Astrid; Riojas-Rodríguez, Horacio; Rangel, Hilda; González-Fernández, Mariana Irina

2013-04-01

To evaluate the vulnerability associated with the occurrence of dengue in two villages of Morelos, Mexico from 2006 to 2009. MATERIALS AND METHODS. A survey on knowledge, risk perception, prevention practices and water use was applied in two villages of Morelos. Using a principal component analysis, an index of local vulnerability to dengue (IVL) was constructed. The association of IVL with the disease at home was assessed using a Chi-square test. The IVL included five components explaining 63% of the variance and was classified in three categories: low, medium and high. There was a significant association between increased vulnerability and prevalence of reported cases of dengue in Temixco and Tlaquiltenango. The study of vulnerability to dengue allows us to identify local needs in the field of health promotion.

The vulnerabilities of the power-grid system: renewable microgrids as an alternative source of energy.

PubMed

Meyer, Victor; Myres, Charles; Bakshi, Nitin

2010-03-01

The objective of this paper is to analyse the vulnerabilities of current power-grid systems and to propose alternatives to using fossil fuel power generation and infrastructure solutions in the form of microgrids, particularly those from renewable energy sources. One of the key potential benefits of microgrids, apart from their inherent sustainability and ecological advantages, is increased resilience. The analysis is targeted towards the context of business process outsourcing in India. However, much of the research on vulnerabilities has been derived from the USA and as such many of the examples cite vulnerabilities in the USA and other developed economies. Nevertheless, the vulnerabilities noted are to a degree common to all grid systems, and so the analysis may be more broadly applicable.

Touch displays: the effects of palm rejection technology on productivity, comfort, biomechanics and positioning.

PubMed

Camilleri, Matt J; Malige, Ajith; Fujimoto, Jeffrey; Rempel, David M

2013-01-01

Direct touch displays can improve the human-computer experience and productivity; however, the higher hand locations may increase shoulder fatigue. Palm rejection (PR) technology may reduce shoulder loads by allowing the palms to rest on the display and increase productivity by registering the touched content and fingertips through the palms rather than shoulders. The effects of PR were evaluated by having participants perform touch tasks while posture and reaction force on the display were measured. Enabling PR, during which the subjects could place the palms on the display (but were not required to), resulted in increased wrist extension, force applied to the display and productivity, and less discomfort, but had no effect on the self-selected positioning of the display. Participants did not deliberately place their palms on the display; therefore, there was no reduction in shoulder load and the increased productivity was not due to improved hand registration. The increased productivity may have been due to reduced interruptions from palm contacts or reduced motor control demands.

A Climate Change Vulnerability Assessment of California's At-Risk Birds

PubMed Central

Gardali, Thomas; Seavy, Nathaniel E.; DiGaudio, Ryan T.; Comrack, Lyann A.

2012-01-01

Conservationists must develop new strategies and adapt existing tools to address the consequences of anthropogenic climate change. To support statewide climate change adaptation, we developed a framework for assessing climate change vulnerability of California's at-risk birds and integrating it into the existing California Bird Species of Special Concern list. We defined climate vulnerability as the amount of evidence that climate change will negatively impact a population. We quantified climate vulnerability by scoring sensitivity (intrinsic characteristics of an organism that make it vulnerable) and exposure (the magnitude of climate change expected) for each taxon. Using the combined sensitivity and exposure scores as an index, we ranked 358 avian taxa, and classified 128 as vulnerable to climate change. Birds associated with wetlands had the largest representation on the list relative to other habitat groups. Of the 29 state or federally listed taxa, 21 were also classified as climate vulnerable, further raising their conservation concern. Integrating climate vulnerability and California's Bird Species of Special Concern list resulted in the addition of five taxa and an increase in priority rank for ten. Our process illustrates a simple, immediate action that can be taken to inform climate change adaptation strategies for wildlife. PMID:22396726

A climate change vulnerability assessment of California's at-risk birds.

PubMed

Gardali, Thomas; Seavy, Nathaniel E; DiGaudio, Ryan T; Comrack, Lyann A

2012-01-01

Conservationists must develop new strategies and adapt existing tools to address the consequences of anthropogenic climate change. To support statewide climate change adaptation, we developed a framework for assessing climate change vulnerability of California's at-risk birds and integrating it into the existing California Bird Species of Special Concern list. We defined climate vulnerability as the amount of evidence that climate change will negatively impact a population. We quantified climate vulnerability by scoring sensitivity (intrinsic characteristics of an organism that make it vulnerable) and exposure (the magnitude of climate change expected) for each taxon. Using the combined sensitivity and exposure scores as an index, we ranked 358 avian taxa, and classified 128 as vulnerable to climate change. Birds associated with wetlands had the largest representation on the list relative to other habitat groups. Of the 29 state or federally listed taxa, 21 were also classified as climate vulnerable, further raising their conservation concern. Integrating climate vulnerability and California's Bird Species of Special Concern list resulted in the addition of five taxa and an increase in priority rank for ten. Our process illustrates a simple, immediate action that can be taken to inform climate change adaptation strategies for wildlife.

Decline in Cancer Screening in Vulnerable Populations? Results of the EDIFICE Surveys.

PubMed

Morère, Jean-François; Eisinger, François; Touboul, Chantal; Lhomel, Christine; Couraud, Sébastien; Viguier, Jérôme

2018-03-05

We studied cancer screening over time and social vulnerability via surveys of representative populations. Individuals aged 50-75 years with no personal history of cancer were questioned about lifetime participation in screening tests, compliance (adherence to recommended intervals [colorectal, breast and cervical cancer]) and opportunistic screening (prostate and lung cancer). The proportion of vulnerable/non-vulnerable individuals remained stable between 2011 and 2016. In 2011, social vulnerability had no impact on screening participation, nor on compliance. In 2014, however, vulnerability was correlated with less frequent uptake of colorectal screening (despite an organised programme) and prostate cancer screening (opportunistic), and also with reduced compliance with recommended intervals (breast and cervical cancer screening). In 2016, the trends observed in 2014 were substantiated and even extended to breast, colorectal and cervical cancer screening uptakes. Social vulnerability has an increasingly negative impact on cancer screening attendance. The phenomenon was identified in 2014 and had expanded by 2016. Although organised programmes have been shown to ensure equitable access to cancer screening, this remains a precarious achievement requiring regular monitoring. Further studies should focus on attitudes of vulnerable populations and on ways to improve cancer awareness campaigns.

Identifying the world's most climate change vulnerable species: a systematic trait-based assessment of all birds, amphibians and corals.

PubMed

Foden, Wendy B; Butchart, Stuart H M; Stuart, Simon N; Vié, Jean-Christophe; Akçakaya, H Resit; Angulo, Ariadne; DeVantier, Lyndon M; Gutsche, Alexander; Turak, Emre; Cao, Long; Donner, Simon D; Katariya, Vineet; Bernard, Rodolphe; Holland, Robert A; Hughes, Adrian F; O'Hanlon, Susannah E; Garnett, Stephen T; Sekercioğlu, Cagan H; Mace, Georgina M

2013-01-01

Climate change will have far-reaching impacts on biodiversity, including increasing extinction rates. Current approaches to quantifying such impacts focus on measuring exposure to climatic change and largely ignore the biological differences between species that may significantly increase or reduce their vulnerability. To address this, we present a framework for assessing three dimensions of climate change vulnerability, namely sensitivity, exposure and adaptive capacity; this draws on species' biological traits and their modeled exposure to projected climatic changes. In the largest such assessment to date, we applied this approach to each of the world's birds, amphibians and corals (16,857 species). The resulting assessments identify the species with greatest relative vulnerability to climate change and the geographic areas in which they are concentrated, including the Amazon basin for amphibians and birds, and the central Indo-west Pacific (Coral Triangle) for corals. We found that high concentration areas for species with traits conferring highest sensitivity and lowest adaptive capacity differ from those of highly exposed species, and we identify areas where exposure-based assessments alone may over or under-estimate climate change impacts. We found that 608-851 bird (6-9%), 670-933 amphibian (11-15%), and 47-73 coral species (6-9%) are both highly climate change vulnerable and already threatened with extinction on the IUCN Red List. The remaining highly climate change vulnerable species represent new priorities for conservation. Fewer species are highly climate change vulnerable under lower IPCC SRES emissions scenarios, indicating that reducing greenhouse emissions will reduce climate change driven extinctions. Our study answers the growing call for a more biologically and ecologically inclusive approach to assessing climate change vulnerability. By facilitating independent assessment of the three dimensions of climate change vulnerability, our approach can be used to devise species and area-specific conservation interventions and indices. The priorities we identify will strengthen global strategies to mitigate climate change impacts.

Social vulnerability from a social ecology perspective: a cohort study of older adults from the National Population Health Survey of Canada

PubMed Central

2014-01-01

Background Numerous social factors, generally studied in isolation, have been associated with older adults’ health. Even so, older people’s social circumstances are complex and an approach which embraces this complexity is desirable. Here we investigate many social factors in relation to one another and to survival among older adults using a social ecology perspective to measure social vulnerability among older adults. Methods 2740 adults aged 65 and older were followed for ten years in the Canadian National Population Health Survey (NPHS). Twenty-three individual-level social variables were drawn from the 1994 NPHS and five Enumeration Area (EA)-level variables were abstracted from the 1996 Canadian Census using postal code linkage. Principal Component Analysis (PCA) was used to identify dimensions of social vulnerability. All social variables were summed to create a social vulnerability index which was studied in relation to ten-year mortality. Results The PCA was limited by low variance (47%) explained by emergent factors. Seven dimensions of social vulnerability emerged in the most robust, yet limited, model: social support, engagement, living situation, self-esteem, sense of control, relations with others and contextual socio-economic status. These dimensions showed complex inter-relationships and were situated within a social ecology framework, considering spheres of influence from the individual through to group, neighbourhood and broader societal levels. Adjusting for age, sex, and frailty, increasing social vulnerability measured using the cumulative social vulnerability index was associated with increased risk of mortality over ten years in a Cox regression model (HR 1.04, 95% CI:1.01-1.07, p = 0.01). Conclusions Social vulnerability has important independent influence on older adults’ health though relationships between contributing variables are complex and do not lend themselves well to fragmentation into a small number of discrete factors. A social ecology perspective provides a candidate framework for further study of social vulnerability among older adults. PMID:25129548

Identifying the World's Most Climate Change Vulnerable Species: A Systematic Trait-Based Assessment of all Birds, Amphibians and Corals

PubMed Central

Foden, Wendy B.; Butchart, Stuart H. M.; Stuart, Simon N.; Vié, Jean-Christophe; Akçakaya, H. Resit; Angulo, Ariadne; DeVantier, Lyndon M.; Gutsche, Alexander; Turak, Emre; Cao, Long; Donner, Simon D.; Katariya, Vineet; Bernard, Rodolphe; Holland, Robert A.; Hughes, Adrian F.; O’Hanlon, Susannah E.; Garnett, Stephen T.; Şekercioğlu, Çagan H.; Mace, Georgina M.

2013-01-01

Climate change will have far-reaching impacts on biodiversity, including increasing extinction rates. Current approaches to quantifying such impacts focus on measuring exposure to climatic change and largely ignore the biological differences between species that may significantly increase or reduce their vulnerability. To address this, we present a framework for assessing three dimensions of climate change vulnerability, namely sensitivity, exposure and adaptive capacity; this draws on species’ biological traits and their modeled exposure to projected climatic changes. In the largest such assessment to date, we applied this approach to each of the world’s birds, amphibians and corals (16,857 species). The resulting assessments identify the species with greatest relative vulnerability to climate change and the geographic areas in which they are concentrated, including the Amazon basin for amphibians and birds, and the central Indo-west Pacific (Coral Triangle) for corals. We found that high concentration areas for species with traits conferring highest sensitivity and lowest adaptive capacity differ from those of highly exposed species, and we identify areas where exposure-based assessments alone may over or under-estimate climate change impacts. We found that 608–851 bird (6–9%), 670–933 amphibian (11–15%), and 47–73 coral species (6–9%) are both highly climate change vulnerable and already threatened with extinction on the IUCN Red List. The remaining highly climate change vulnerable species represent new priorities for conservation. Fewer species are highly climate change vulnerable under lower IPCC SRES emissions scenarios, indicating that reducing greenhouse emissions will reduce climate change driven extinctions. Our study answers the growing call for a more biologically and ecologically inclusive approach to assessing climate change vulnerability. By facilitating independent assessment of the three dimensions of climate change vulnerability, our approach can be used to devise species and area-specific conservation interventions and indices. The priorities we identify will strengthen global strategies to mitigate climate change impacts. PMID:23950785

Vulnerability Assessments and Resilience Planning at Federal Facilities. Preliminary Synthesis of Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moss, R. H.; Blohm, A. J.; Delgado, A.

2015-08-15

U.S. government agencies are now directed to assess the vulnerability of their operations and facilities to climate change and to develop adaptation plans to increase their resilience. Specific guidance on methods is still evolving based on the many different available frameworks. Agencies have been experimenting with these frameworks and approaches. This technical paper synthesizes lessons and insights from a series of research case studies conducted by the investigators at facilities of the U.S. Department of Energy and the Department of Defense. The purpose of the paper is to solicit comments and feedback from interested program managers and analysts before finalmore » conclusions are published. The paper describes the characteristics of a systematic process for prioritizing needs for adaptation planning at individual facilities and examines requirements and methods needed. It then suggests a framework of steps for vulnerability assessments at Federal facilities and elaborates on three sets of methods required for assessments, regardless of the detailed framework used. In a concluding section, the paper suggests a roadmap to further develop methods to support agencies in preparing for climate change. The case studies point to several preliminary conclusions; (1) Vulnerability assessments are needed to translate potential changes in climate exposure to estimates of impacts and evaluation of their significance for operations and mission attainment, in other words into information that is related to and useful in ongoing planning, management, and decision-making processes; (2) To increase the relevance and utility of vulnerability assessments to site personnel, the assessment process needs to emphasize the characteristics of the site infrastructure, not just climate change; (3) A multi-tiered framework that includes screening, vulnerability assessments at the most vulnerable installations, and adaptation design will efficiently target high-risk sites and infrastructure; (4) Vulnerability assessments can be connected to efforts to improve facility resilience to motivate participation; and (5) Efficient, scalable methods for vulnerability assessment can be developed, but additional case studies and evaluation are required.« less

BROAD-SCALE ASSESSMENT OF WETLAND VULNERABILITY USING GIS AND LANDSCAPE-ECOLOGICAL METRICS

EPA Science Inventory

Landscape-ecological indicators of ecosystem integrity are increasingly being sought for use in habitat suitability assessments, habitat vulnerability assessments, and as a means to set goals for restoration projects. We utilized currently available information from the Arkansas...

Modelling the changing cumulative vulnerability to climate-related hazards for river basin management using a GIS-based multicriteria decision approach

NASA Astrophysics Data System (ADS)

Hung, Hung-Chih; Wu, Ju-Yu; Hung, Chih-Hsuan

2017-04-01

1. Background Asia-Pacific region is one of the most vulnerable areas of the world to climate-related hazards and extremes due to rapid urbanization and over-development in hazard-prone areas. It is thus increasingly recognized that the management of land use and reduction of hazard risk are inextricably linked. This is especially critical from the perspective of integrated river basin management. A range of studies has targeted existing vulnerability assessments. However, limited attention has been paid to the cumulative effects of multiple vulnerable factors and their dynamics faced by local communities. This study proposes a novel methodology to access the changing cumulative vulnerability to climate-related hazards, and to examine the relationship between the attraction factors relevant to the general process of urbanization and vulnerability variability with a focus on a river basin management unit. 2. Methods and data The methods applied in this study include three steps. First, using Intergovernmental Panel on Climate Change's (IPCC) approach, a Cumulative Vulnerability Assessment Framework (CVAF) is built with a goal to characterize and compare the vulnerability to climate-related hazards within river basin regions based on a composition of multiple indicators. We organize these indicator metrics into three categories: (1) hazard exposure; (2) socioeconomic sensitivity, and (3) adaptive capacity. Second, the CVAF is applied by combining a geographical information system (GIS)-based spatial statistics technique with a multicriteria decision analysis (MCDA) to assess and map the changing cumulative vulnerability, comparing conditions in 1996 and 2006 in Danshui River Basin, Taiwan. Third, to examine the affecting factors of vulnerability changing, we develop a Vulnerability Changing Model (VCM) using four attraction factors to reflect how the process of urban developments leads to vulnerability changing. The factors are transport networks, land uses, production values of industries, and infrastructures. We then conduct a regression analysis to test the VCM. To illustrate the proposed methodology, the data are collected from the National Science and Technology Center for Disaster Reduction, Taiwan as well as the National Land Use Investigation and official census statistics. 3. Results and policy implications Results of CVAF analysis demonstrate heterogeneous patterns of vulnerability in the region, and highlight trends of long-term changes. The vulnerable areas unfold as clustered patterns and spatial analogues across regions, rather than randomly distributed. Highest cumulative vulnerability is concentrated in densely populated and downstream reaches (such as Taipei City) of the Danshui River in both time periods. When examining the VCM, it indicates that upper stream and more remote areas generally show low vulnerability, increases are observed in some areas between 1996 and 2006 due to land use intensification, industrial and infrastructure expansion. These findings suggest that land use planning should consider the socioeconomic progression and infrastructure investment factors that contribute to urban sprawl and address current as well as future urban developments vulnerable to hazard risk transmission. The cumulative vulnerability assessment, mapping methods and modelling presented here can be applied to other climate change and hazard risks to highlight priority areas for further investigation and contribute towards improving river basin management.

Identifying Population Vulnerable to Extreme Heat Events in San Jose, California.

NASA Astrophysics Data System (ADS)

Rivera, A. L.

2016-12-01

The extreme heat days not only make cities less comfortable for living but also they are associated with increased morbidity and mortality. Mapping studies have demonstrated spatial variability in heat vulnerability. A study conducted between 2000 and 2011 in New York City shows that deaths during heat waves was more likely to occur in black individuals, at home in census tracts which received greater public assistance. This map project intends to portray areas in San Jose California that are vulnerable to extreme heat events. The variables considered to build a vulnerability index are: land surface temperature, vegetated areas (NDVI), and people exposed to these area (population density).

Post-fire Tree Mortality: Heating Increases Vulnerability to Cavitation in Longleaf Pine Branches

NASA Astrophysics Data System (ADS)

Lodge, A.; Kavanagh, K.; Dickinson, M. B.

2016-12-01

Tree mortality following wild and prescribed fires is of interest to both researchers and land managers. While some models exist that can predict mortality following fires, process-based models that incorporate physiological mechanisms of mortality are still being developed and improved. Delayed post-fire tree mortality has recently received increased attention, in part due to an increased use of prescribed fire as a restoration and management tool. One hypothesized mechanism of delayed mortality in trees is disruption of water transport in xylem due to exposure to the heat plume of a fire. This heat plume rapidly increases the vapor pressure deficit in the tree canopy, quickly increasing the tension on the water held in the xylem and leaves, potentially leading to cavitation. Cavitated xylem conduits can no longer transport water, eventually leading to tree death. We conducted a laboratory experiment examining whether heating stems increases their vulnerability to cavitation. We placed longleaf pine (Pinus palustris) branches in a water bath at sub-lethal temperatures (<60°C) and applied pressure in a cavitation chamber to simulate a range of xylem tension levels that may occur during fire. Percent loss of conductivity was measured following cavitation induced by various levels of applied pressure. When we compared the resulting vulnerability curves of heated branches to those of branches pressurized at room temperature, we observed increased vulnerability to cavitation in the heated samples especially at lower pressures. P50, or the pressure at which 50% of conductivity has been lost, decreased by 18% on branches heated to approximately 54°C. This suggests that stems heated during fires may be more vulnerable to cavitation, and provides some support for hydraulic disruption as a mechanism for post-fire tree mortality. Continued advancement in understanding of the mechanisms leading to delayed mortality will improve models predicting tree mortality.

Social dimensions of vulnerability to glacier-hydrology hazards in Peru and Nepal

NASA Astrophysics Data System (ADS)

McDowell, Graham; Carey, Mark; Huggel, Christian; Kargel, Jeffrey S.

2014-05-01

Snow and ice hazards affect populations worldwide, and prevention and adaptation plans must devote more attention to the human dimensions of these hazards. Historically, most research on glacier hazards has emphasized glacial lake outburst floods (GLOFs) and rock-ice landslides. This work often focuses on technical approaches or scientific knowledge about these high-magnitude and low-frequency hazards. This study examines a different type of cryospheric hazard, one that is low-magnitude and high-frequency, especially under future climate change projections: the increasingly recognized hydrologic hazards related to runoff variability in downstream communities below shrinking glaciers. By focusing on actual water users in glacier-fed watersheds, the research helps illuminate key vulnerabilities to hydrological change. It demonstrates that people are indeed vulnerable to decreased runoff, but that these vulnerabilities must be analyzed in the context of global change, including socio-economic and political variables, and not just through technical or scientific approaches. The study examines water use for export-oriented agriculture in Peru's billion-dollar Chavimochic Project, which depends on a single canal from the Santa River that could be damaged by a GLOF or avalanche. Or the canal could experience declining water supplies in the future if water use increases, particularly due to international agricultural demands, while water supplies from glacial ice decreases. The study also provides insights from Khumbu, Nepal, where changing hydrological conditions are leading to reduced water access for household uses, declining crop yields, reduced water access for meeting the high water demands of tourists, and reduced hydro-electricity generation capabilities. Although these effects are widespread, there are clear patterns of socially determined vulnerability among the population, with low livelihood diversity an important indicator of increased susceptibility to harm. While focusing on hydrologic variability and vulnerability, this poster's societal orientation has far-reaching implications for the analysis of all cryospheric hazards where vulnerability and resilience are affected by a range of human and environmental forces.

Estimating vegetation vulnerability to detect areas prone to land degradation in the Mediterranean basin

NASA Astrophysics Data System (ADS)

Imbrenda, Vito; Coluzzi, Rosa; D'Emilio, Mariagrazia; Lanfredi, Maria; Simoniello, Tiziana

2013-04-01

Vegetation is one of the key components to study land degradation vulnerability because of the complex interactions and feedbacks that link it to soil. In the Mediterranean region, degradation phenomena are due to a mix of predisposing factors (thin soil horizons, low soil organic matter, increasing aridity, etc.) and bad management practices (overgrazing, deforestation, intensification of agriculture, tourism development). In particular, in areas threatened by degradation processes but still covered by vegetation, large scale soil condition evaluation is a hard task and the detection of stressed vegetation can be useful to identify on-going soil degradation phenomena and to reduce their impacts through interventions for recovery/rehabilitation. In this context the use of satellite time series can increase the efficacy and completeness of the land degradation assessment, providing precious information to understand vegetation dynamics. In order to estimate vulnerability levels in Basilicata (a Mediterranean region of Southern Italy) in the framework of PRO-LAND project (PO-FESR Basilicata 2007-2013), we crossed information on potential vegetation vulnerability with information on photosynthetic activity dynamics. Potential vegetation vulnerability represents the vulnerability related to the type of present cover in terms of fire risk, erosion protection, drought resistance and plant cover distribution. It was derived from an updated land cover map by separately analyzing each factor, and then by combining them to obtain concise information on the possible degradation exposure. The analysis of photosynthetic activity dynamics provides information on the status of vegetation, that is fundamental to discriminate the different vulnerability levels within the same land cover, i.e. the same potential vulnerability. For such a purpose, we analyzed a time series (2000-2010) of a satellite vegetation index (MODIS NDVI) with 250m resolution, available as 16-day composite from the NASA LP DAAC dataset. Vegetation activity trends were estimated and then normalized to the starting conditions to obtain the percentage variation (NDVI-PV) for the considered period. Information on the potential vulnerability and vegetation activity dynamics were classified into indexes and combined to obtain the final map of the actual vegetation vulnerability and to identify on-going degradation phenomena and priority sites within areas already compromised. As for the investigated area, this map shows a composite picture in which only a few values of high vulnerability are scattered along areas where medium-high vulnerability values generally prevail. Here, we singled out two kind of areas: one largely devoted to intensive agriculture, and other one mostly characterized by bare soils and sparse vegetation. On the contrary, a large part of natural and seminatural vegetation located along the Apennine chain does not show critical vulnerability values. By comparing the vegetation vulnerability map with the vulnerability map due to anthropic factors (pressure induced by agricultural and grazing activities, estimated by indicators derived from census data), we found correlation, confirming the anthropogenic cause of vulnerability and therefore the major role held by soil management in areas mainly devoted to intensive farming.

Evaluation of a Heat Vulnerability Index on Abnormally Hot Days: An Environmental Public Health Tracking Study

PubMed Central

Mann, Jennifer K.; Alfasso, Ruth; English, Paul B.; King, Galatea C.; Lincoln, Rebecca A.; Margolis, Helene G.; Rubado, Dan J.; Sabato, Joseph E.; West, Nancy L.; Woods, Brian; Navarro, Kathleen M.; Balmes, John R.

2012-01-01

Background: Extreme hot weather conditions have been associated with increased morbidity and mortality, but risks are not evenly distributed throughout the population. Previously, a heat vulnerability index (HVI) was created to geographically locate populations with increased vulnerability to heat in metropolitan areas throughout the United States. Objectives: We sought to determine whether areas with higher heat vulnerability, as characterized by the HVI, experienced higher rates of morbidity and mortality on abnormally hot days. Methods: We used Poisson regression to model the interaction of HVI and deviant days (days whose deviation of maximum temperature from the 30-year normal maximum temperature is at or above the 95th percentile) on hospitalization and mortality counts in five states participating in the Environmental Public Health Tracking Network for the years 2000 through 2007. Results: The HVI was associated with higher hospitalization and mortality rates in all states on both normal days and deviant days. However, associations were significantly stronger (interaction p-value < 0.05) on deviant days for heat-related illness, acute renal failure, electrolyte imbalance, and nephritis in California, heat-related illness in Washington, all-cause mortality in New Mexico, and respiratory hospitalizations in Massachusetts. Conclusion: Our results suggest that the HVI may be a marker of health vulnerability in general, although it may indicate greater vulnerability to heat in some cases. PMID:22538066

Community vulnerability to health impacts of wildland fire ...

EPA Pesticide Factsheets

Identifying communities vulnerable to adverse health effects from exposure to wildfire smoke may help prepare responses, increase the resilience to smoke and improve public health outcomes during smoke days. We developed a Community Health-Vulnerability Index (CHVI) based on factors known to increase the risks of health effects from air pollution and wildfire smoke exposures. These factors included county prevalence rates for asthma in children and adults, chronic obstructive pulmonary disease, hypertension, diabetes, obesity, percent of population 65 years of age and older, and indicators of socioeconomic status including poverty, education, income and unemployment. Using air quality simulated for the period between 2008 and 2012 over the continental U.S. we also characterized the population size at risk with respect to the level and duration of exposure to fire-originated fine particulate matter (fire-PM2.5) and CHVI. We estimate that 10% of the population (30.5 million) lived in the areas where the contribution of fire-PM2.5 to annual average ambient PM2.5 was high (>1.5 µg m3) and that 10.3 million individuals experienced unhealthy air quality levels for more than 10 days due to smoke. Using CHVI we identified the most vulnerable counties and determined that these communities experience more smoke exposures in comparison to less vulnerable communities. We describe the development of an index of community vulnerability for the health effects of smoke based o

Affiliation buffers stress: cumulative genetic risk in oxytocin-vasopressin genes combines with early caregiving to predict PTSD in war-exposed young children.

PubMed

Feldman, R; Vengrober, A; Ebstein, R P

2014-03-11

Research indicates that risk for post-traumatic stress disorder (PTSD) is shaped by the interaction between genetic vulnerability and early caregiving experiences; yet, caregiving has typically been assessed by adult retrospective accounts. Here, we employed a prospective longitudinal design with real-time observations of early caregiving combined with assessment of genetic liability along the axis of vasopressin-oxytocin (OT) gene pathways to test G × E contributions to PTSD. Participants were 232 young Israeli children (1.5-5 years) and their parents, including 148 living in zones of continuous war and 84 controls. A cumulative genetic risk factor was computed for each family member by summing five risk alleles across three genes (OXTR, CD38 and AVPR1a) previously associated with psychopathology, sociality and caregiving. Child PTSD was diagnosed and mother-child interactions were observed in multiple contexts. In middle childhood (7-8 years), child psychopathology was re-evaluated. War exposure increased propensity to develop Axis-I disorder by threefold: 60% of exposed children displayed a psychiatric disorder by middle childhood and 62% of those showed several comorbid disorders. On the other hand, maternal sensitive support reduced risk for psychopathology. G × E effect was found for child genetic risk: in the context of war exposure, greater genetic risk on the vasopressin-OT pathway increased propensity for psychopathology. Among exposed children, chronicity of PTSD from early to middle childhood was related to higher child, maternal and paternal genetic risk, low maternal support and greater initial avoidance symptoms. Child avoidance was predicted by low maternal support and reduced mother-child reciprocity. These findings underscore the saliency of both genetic and behavioral facets of the human affiliation system in shaping vulnerability to PTSD as well as providing an underlying mechanism of post-traumatic resilience.

Affiliation buffers stress: cumulative genetic risk in oxytocin–vasopressin genes combines with early caregiving to predict PTSD in war-exposed young children

PubMed Central

Feldman, R; Vengrober, A; Ebstein, R P

2014-01-01

Research indicates that risk for post-traumatic stress disorder (PTSD) is shaped by the interaction between genetic vulnerability and early caregiving experiences; yet, caregiving has typically been assessed by adult retrospective accounts. Here, we employed a prospective longitudinal design with real-time observations of early caregiving combined with assessment of genetic liability along the axis of vasopressin–oxytocin (OT) gene pathways to test G × E contributions to PTSD. Participants were 232 young Israeli children (1.5–5 years) and their parents, including 148 living in zones of continuous war and 84 controls. A cumulative genetic risk factor was computed for each family member by summing five risk alleles across three genes (OXTR, CD38 and AVPR1a) previously associated with psychopathology, sociality and caregiving. Child PTSD was diagnosed and mother–child interactions were observed in multiple contexts. In middle childhood (7–8 years), child psychopathology was re-evaluated. War exposure increased propensity to develop Axis-I disorder by threefold: 60% of exposed children displayed a psychiatric disorder by middle childhood and 62% of those showed several comorbid disorders. On the other hand, maternal sensitive support reduced risk for psychopathology. G × E effect was found for child genetic risk: in the context of war exposure, greater genetic risk on the vasopressin–OT pathway increased propensity for psychopathology. Among exposed children, chronicity of PTSD from early to middle childhood was related to higher child, maternal and paternal genetic risk, low maternal support and greater initial avoidance symptoms. Child avoidance was predicted by low maternal support and reduced mother–child reciprocity. These findings underscore the saliency of both genetic and behavioral facets of the human affiliation system in shaping vulnerability to PTSD as well as providing an underlying mechanism of post-traumatic resilience. PMID:24618689

Emotional reactivity to a single inhalation of 35% carbon dioxide and its association with later symptoms of posttraumatic stress disorder and anxiety in soldiers deployed to Iraq.

PubMed

Telch, Michael J; Rosenfield, David; Lee, Han-Joo; Pai, Anushka

2012-11-01

The identification of modifiable predeployment vulnerability factors that increase the risk of combat stress reactions among soldiers once deployed to a war zone offers significant potential for the prevention of posttraumatic stress disorder (PTSD) and other combat-related stress disorders. Adults with anxiety disorders display heightened emotional reactivity to a single inhalation of 35% carbon dioxide (CO(2)); however, data investigating prospective linkages between emotional reactivity to CO(2) and susceptibility to war-zone stress reactions are lacking. To investigate the association of soldiers' predeployment emotional reactivity to 35% CO(2) challenge with several indices of subsequent war-zone stress symptoms assessed monthly while deployed in Iraq. Prospective cohort study of 158 soldiers with no history of deployment to a war zone were recruited from the Texas Combat Stress Risk Study between April 2, 2007, and August 28, 2009. Multilevel regression models were used to investigate the association between emotional reactivity to 35% CO(2) challenge (assessed before deployment) and soldiers' reported symptoms of general anxiety/stress, PTSD, and depression while deployed to Iraq. Growth curves of PTSD, depression, and general anxiety/stress symptoms showed a significant curvilinear relationship during the 16-month deployment period. War-zone stressors reported in theater were associated with symptoms of general anxiety/stress, PTSD, and depression. Consistent with the prediction, soldiers' emotional reactivity to a single inhalation of 35% CO(2)-enriched air before deployment significantly potentiated the effects of war-zone stressors on the subsequent development of PTSD symptoms and general anxiety/stress symptoms but not on the development of depression, even after accounting for the effects of trait anxiety and the presence of past or current Axis I mental disorders. Soldiers' emotional reactivity to a 35% CO(2) challenge may serve as a vulnerability factor for increasing soldiers' risk for PTSD and general anxiety/stress symptoms in response to war-zone stressors.

Vulnerable Populations Perceive Their Health as at Risk from Climate Change.

PubMed

Akerlof, Karen L; Delamater, Paul L; Boules, Caroline R; Upperman, Crystal R; Mitchell, Clifford S

2015-12-04

Climate change is already taking a toll on human health, a toll that is likely to increase in coming decades. The relationship between risk perceptions and vulnerability to climate change's health threats has received little attention, even though an understanding of the dynamics of adaptation among particularly susceptible populations is becoming increasingly important. We demonstrate that some people whose health will suffer the greatest harms from climate change-due to social vulnerability, health susceptibility, and exposure to hazards-already feel they are at risk. In a 2013 survey we measured Maryland residents' climate beliefs, health risk perceptions, and household social vulnerability characteristics, including medical conditions (n = 2126). We paired survey responses with secondary data sources for residence in a floodplain and/or urban heat island to predict perceptions of personal and household climate health risk. General health risk perceptions, political ideology, and climate beliefs are the strongest predictors. Yet, people in households with the following characteristics also see themselves at higher risk: members with one or more medical conditions or disabilities; low income; racial/ethnic minorities; and residence in a floodplain. In light of these results, climate health communication among vulnerable populations should emphasize protective actions instead of risk messages.

Vulnerable Populations Perceive Their Health as at Risk from Climate Change

PubMed Central

Akerlof, Karen L.; Delamater, Paul L.; Boules, Caroline R.; Upperman, Crystal R.; Mitchell, Clifford S.

2015-01-01

Climate change is already taking a toll on human health, a toll that is likely to increase in coming decades. The relationship between risk perceptions and vulnerability to climate change’s health threats has received little attention, even though an understanding of the dynamics of adaptation among particularly susceptible populations is becoming increasingly important. We demonstrate that some people whose health will suffer the greatest harms from climate change—due to social vulnerability, health susceptibility, and exposure to hazards—already feel they are at risk. In a 2013 survey we measured Maryland residents’ climate beliefs, health risk perceptions, and household social vulnerability characteristics, including medical conditions (n = 2126). We paired survey responses with secondary data sources for residence in a floodplain and/or urban heat island to predict perceptions of personal and household climate health risk. General health risk perceptions, political ideology, and climate beliefs are the strongest predictors. Yet, people in households with the following characteristics also see themselves at higher risk: members with one or more medical conditions or disabilities; low income; racial/ethnic minorities; and residence in a floodplain. In light of these results, climate health communication among vulnerable populations should emphasize protective actions instead of risk messages. PMID:26690184

Mapping the Decadal Spatio-temporal Variation of Social Vulnerability to Hydro-climatic Extremes over India

NASA Astrophysics Data System (ADS)

H, V.; Karmakar, S.; Ghosh, S.

2015-12-01

Human induced global warming is unequivocal and observational studies shows that, this has led to increase in the intensity and frequency of hydro-climatic extremes, most importantly precipitation extreme, heat waves and drought; and also is expected to be increased in the future. The occurrence of these extremes have a devastating effects on nation's economy and on societal well-being. Previous studies on India provided the evidences of significant changes in the precipitation extreme from pre- to post-1950, with huge spatial heterogeneity; and projections of heat waves indicated that significant part of India will experience heat stress conditions in the future. Under these circumstance, it is necessary to develop a nation-wide social vulnerability map to scrutinize the adequacy of existing emergency management. Yet there has been no systematic past efforts on mapping social vulnerability to hydro-climatic extremes at nation-wide for India. Therefore, immediate efforts are required to quantify the social vulnerability, particularly developing country like India, where major transformations in demographic characteristics and development patterns are evident during past decades. In the present study, we perform a comprehensive spatio-temporal social vulnerability analysis by considering multiple sensitive indicators for three decades (1990-2010) which identifies the hot-spots, with higher vulnerability to hydro-climatic extremes. The population datasets are procured from Census of India and the meteorological datasets are obtained from India Meteorological Department (IMD). The study derives interesting results on decadal changes of spatial distribution of risk, considering social vulnerability and hazard to extremes.

The Role of Narcissistic Vulnerability in Predicting Adult Posttraumatic Symptoms from Childhood Sexual Abuse.

PubMed

Bachar, Eytan; Canetti, Laura; Hadar, Hilit; Baruch, Julia; Dor, Yehuda; Freedman, Sara

2015-10-01

The aim of the present study is to determine whether narcissistic vulnerability can aid in clarifying the debate regarding the relationship between childhood sexual abuse (CSA) and adulthood adjustment to traumatic events. 157 survivors (mean age = 31.1, SD = 10.9) of a traumatic event (war activities and road and work accidents) were assessed 1 week, 1, and 4 months following the event. Of the 157 participants, 15 reported experiencing CSA, and 26 reported experiencing childhood physical abuse (CPA). In the first-week assessment, patients were administered the Narcissistic Vulnerability Scale (NVS) and the Beck Depression Inventory (BDI). In the follow-up assessments, subjects were interviewed on the Clinician-Administered PTSD Scale. Narcissistic vulnerability was found, both in 1- and 4-month follow-ups, to increase the likelihood of participants who experienced CSA to develop PTSD symptoms later in their adult life, when exposed to other additional trauma. Narcissistic vulnerability, in both follow-ups, did not increase the likelihood of participants who experienced CPA to develop PTSD symptoms later in their life when exposed to other additional trauma. The NVS predicted the development of PTSD symptoms in the whole sample, both in the 1- and 4-month follow-ups, above and beyond the prediction of the BDI. In other words, narcissistic vulnerability can add additional information above and beyond general negative emotionality. In conclusion, it is recommended to take into consideration the interplay between CSA and the individual's narcissistic vulnerability when assessing the long term effects of CSA such as acute or chronic PTSD.

Implicit theories of a desire for fame.

PubMed

Maltby, John; Day, Liz; Giles, David; Gillett, Raphael; Quick, Marianne; Langcaster-James, Honey; Linley, P Alex

2008-05-01

The aim of the present studies was to generate implicit theories of a desire for fame among the general population. In Study 1, we were able to develop a nine-factor analytic model of conceptions of the desire to be famous that initially comprised nine separate factors; ambition, meaning derived through comparison with others, psychologically vulnerable, attention seeking, conceitedness, social access, altruistic, positive affect, and glamour. Analysis that sought to examine replicability among these factors suggested that three factors (altruistic, positive affect, and glamour) neither display factor congruence nor display adequate internal reliability. A second study examined the validity of these factors in predicting profiles of individuals who may desire fame. The findings from this study suggested that two of the nine factors (positive affect and altruism) could not be considered strong factors within the model. Overall, the findings suggest that implicit theories of a desire for fame comprise six factors. The discussion focuses on how an implicit model of a desire for fame might progress into formal theories of a desire for fame.

Perceiving emotions in neutral faces: expression processing is biased by affective person knowledge.

PubMed

Suess, Franziska; Rabovsky, Milena; Abdel Rahman, Rasha

2015-04-01

According to a widely held view, basic emotions such as happiness or anger are reflected in facial expressions that are invariant and uniquely defined by specific facial muscle movements. Accordingly, expression perception should not be vulnerable to influences outside the face. Here, we test this assumption by manipulating the emotional valence of biographical knowledge associated with individual persons. Faces of well-known and initially unfamiliar persons displaying neutral expressions were associated with socially relevant negative, positive or comparatively neutral biographical information. The expressions of faces associated with negative information were classified as more negative than faces associated with neutral information. Event-related brain potential modulations in the early posterior negativity, a component taken to reflect early sensory processing of affective stimuli such as emotional facial expressions, suggest that negative affective knowledge can bias the perception of faces with neutral expressions toward subjectively displaying negative emotions. © The Author (2014). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Do you remember your sad face? The roles of negative cognitive style and sad mood.

PubMed

Caudek, Corrado; Monni, Alessandra

2013-01-01

We studied the effects of negative cognitive style, sad mood, and facial affect on the self-face advantage in a sample of 66 healthy individuals (mean age 26.5 years, range 19-47 years). The sample was subdivided into four groups according to inferential style and responsivity to sad mood induction. Following a sad mood induction, we examined the effect on working memory of an incidental association between facial affect, facial identity, and head-pose orientation. Overall, head-pose recognition was more accurate for the self-face than for nonself face (self-face advantage, SFA). However, participants high in negative cognitive style who experienced higher levels of sadness displayed a stronger SFA for sad expressions than happy expressions. The remaining participants displayed an opposite bias (a stronger SFA for happy expressions than sad expressions), or no bias. These findings highlight the importance of trait-vulnerability status in the working memory biases related to emotional facial expressions.

Immune-related effects from predation risk in Neotropical blue-black grassquits (Volatinia jacarina).

PubMed

Caetano, João V O; Maia, Maya R; Manica, Lilian T; Macedo, Regina H

2014-11-01

Predation is a major force shaping natural history traits of birds because of their vulnerability during nesting and higher visibility during diurnal activities. For most birds in the Neotropics, predation is the major cause of nest failure due to the region's high diversity and abundance of predators. The blue-black grassquit (Volatinia jacarina), similarly to other small passerines in the savanna region of central Brazil, suffers extremely high rates of nest predation. Additionally, males may be particularly vulnerable to predators since they are very conspicuous when executing courtship displays. We assessed some of the non-lethal costs of predation risk on this species by comparing physiological and morphological parameters of birds exposed to predator vocalizations with that of control subjects exposed to non-predator vocalizations. Birds exposed to the predator vocalizations exhibited an immune-related reaction (changes in their H/L ratio), but no changes were observed in other biological parameters measured. This article is part of a Special Issue entitled: Neotropical Behaviour. Copyright © 2014 Elsevier B.V. All rights reserved.

Alcohol intake among adolescent students and association with social capital and socioeconomic status.

PubMed

Jorge, Kelly Oliva; Paiva, Paula Cristina Pelli; Ferreira, Efigênia Ferreira E; Vale, Miriam Pimenta do; Kawachi, Ichiro; Zarzar, Patrícia Maria

2018-03-01

The aim was to evaluate the prevalence of alcohol consumption, binge drinking and their association with social capital and socioeconomic factors among Brazilian adolescents students. A cross-sectional study was carried out with a randomly selected representative sample of 936 adolescents aged 15 to 19 years. Information on alcohol consumption, social capital and socioeconomic status was collected using the Alcohol Use Disorders Identification Test, the Integrated Questionnaire for the Measurement of Social Capital and Social Vulnerability Index, respectively. The prevalence of alcohol consumption was 50.3% and binge drinking 36% the last year. Adolescents who reported believing that people in their community could help solve a collective problem (with the water supply) and those classified as having high social vulnerability had lower likelihood of binge drinking (PR = 0.776 [95%CI:0.620 to 0.971] and PR = 0.660 [95%CI:0.542 to 0.803], respectively). The prevalence of alcohol consumption and binge drinking the last year is high among participants. Those with higher socioeconomic status as well as lower perceptions of community capital social are more likely to display binge-drinking behavior.

Identifying mismatches between institutional perceptions of water-related risk drivers and water management strategies in three river basin areas

NASA Astrophysics Data System (ADS)

Räsänen, Aleksi; Juhola, Sirkku; Monge Monge, Adrián; Käkönen, Mira; Kanninen, Markku; Nygren, Anja

2017-07-01

Water-related risks and vulnerabilities are driven by variety of stressors, including climate and land use change, as well as changes in socio-economic positions and political landscapes. Hence, water governance, which addresses risks and vulnerabilities, should target multiple stressors. We analyze the institutional perceptions of the drivers and strategies for managing water-related risks and vulnerabilities in three regionally important river basin areas located in Finland, Mexico, and Laos. Our analysis is based on data gathered through participatory workshops and complemented by qualitative content analysis of relevant policy documents. The identified drivers and proposed risk reduction strategies showed the multidimensionality and context-specificity of water-related risks and vulnerabilities across study areas. Most of the identified drivers were seen to increase risks, but some of the drivers were positive trends, and drivers also included also policy instruments that can both increase or decrease risks. Nevertheless, all perceived drivers were not addressed with suggested risk reduction strategies. In particular, most of the risk reduction strategies were incremental adjustments, although many of the drivers classified as most important were large-scale trends, such as climate change, land use changes and increase in foreign investments. We argue that there is a scale mismatch between the identified drivers and suggested strategies, which questions the opportunity to manage the drivers by single-scale incremental adjustments. Our study suggests that for more sustainable risk and vulnerability reduction, the root causes of water-related risks and vulnerabilities should be addressed through adaptive multi-scale governance that carefully considers the context-specificity and the multidimensionality of the associated drivers and stressors.

Calibration of groundwater vulnerability mapping using the generalized reduced gradient method.

PubMed

Elçi, Alper

2017-12-01

Groundwater vulnerability assessment studies are essential in water resources management. Overlay-and-index methods such as DRASTIC are widely used for mapping of groundwater vulnerability, however, these methods mainly suffer from a subjective selection of model parameters. The objective of this study is to introduce a calibration procedure that results in a more accurate assessment of groundwater vulnerability. The improvement of the assessment is formulated as a parameter optimization problem using an objective function that is based on the correlation between actual groundwater contamination and vulnerability index values. The non-linear optimization problem is solved with the generalized-reduced-gradient (GRG) method, which is numerical algorithm based optimization method. To demonstrate the applicability of the procedure, a vulnerability map for the Tahtali stream basin is calibrated using nitrate concentration data. The calibration procedure is easy to implement and aims the maximization of correlation between observed pollutant concentrations and groundwater vulnerability index values. The influence of each vulnerability parameter in the calculation of the vulnerability index is assessed by performing a single-parameter sensitivity analysis. Results of the sensitivity analysis show that all factors are effective on the final vulnerability index. Calibration of the vulnerability map improves the correlation between index values and measured nitrate concentrations by 19%. The regression coefficient increases from 0.280 to 0.485. It is evident that the spatial distribution and the proportions of vulnerability class areas are significantly altered with the calibration process. Although the applicability of the calibration method is demonstrated on the DRASTIC model, the applicability of the approach is not specific to a certain model and can also be easily applied to other overlay-and-index methods. Copyright © 2017 Elsevier B.V. All rights reserved.

Calibration of groundwater vulnerability mapping using the generalized reduced gradient method

NASA Astrophysics Data System (ADS)

Elçi, Alper

2017-12-01

Groundwater vulnerability assessment studies are essential in water resources management. Overlay-and-index methods such as DRASTIC are widely used for mapping of groundwater vulnerability, however, these methods mainly suffer from a subjective selection of model parameters. The objective of this study is to introduce a calibration procedure that results in a more accurate assessment of groundwater vulnerability. The improvement of the assessment is formulated as a parameter optimization problem using an objective function that is based on the correlation between actual groundwater contamination and vulnerability index values. The non-linear optimization problem is solved with the generalized-reduced-gradient (GRG) method, which is numerical algorithm based optimization method. To demonstrate the applicability of the procedure, a vulnerability map for the Tahtali stream basin is calibrated using nitrate concentration data. The calibration procedure is easy to implement and aims the maximization of correlation between observed pollutant concentrations and groundwater vulnerability index values. The influence of each vulnerability parameter in the calculation of the vulnerability index is assessed by performing a single-parameter sensitivity analysis. Results of the sensitivity analysis show that all factors are effective on the final vulnerability index. Calibration of the vulnerability map improves the correlation between index values and measured nitrate concentrations by 19%. The regression coefficient increases from 0.280 to 0.485. It is evident that the spatial distribution and the proportions of vulnerability class areas are significantly altered with the calibration process. Although the applicability of the calibration method is demonstrated on the DRASTIC model, the applicability of the approach is not specific to a certain model and can also be easily applied to other overlay-and-index methods.

Assessing the Vulnerability of Agriculture to Climate Change in Jordan

NASA Astrophysics Data System (ADS)

Khresat, Sa'eb; Shraidaeh, Fadi; Maddat, Amer

2015-04-01

Climate change represents one of the greatest environmental, social and economic threats facing Jordan. In particular, the combined effects of climate change and water scarcity threaten to affect food and water resources that are critical for livelihoods in Jordan. This is especially true for those communities who live in the dryland area in the country and who rely wholly on rain-fed agriculture. The exact nature and extent of the impact of climate change on temperature and precipitation distribution pattern remain uncertain and it is the poor and vulnerable who will be the most susceptible to climate change adverse effects. A vulnerability assessment of rain fed agriculture to climate change and variability in semi-arid parts of Jordan was conducted in 2014. The purpose of this study is to assess the vulnerability and resilience of the most vulnerable groups where rainfed and irrigated agriculture is practiced. Also, the study focused on quantifying the impacts on agricultural productivity in response to climate change. This will help policymakers and researchers better understand and anticipate the likely impacts of climate change on agriculture and on vulnerable communities in Jordan. Also, it will provide them with tools to identify and implement appropriate adaptation strategies. The data used includes; Representative Concentration Pathways (RCPs), RCP 4.5 and RCP 8.5 adopted by the IPCC for its fifth Assessment Report (AR5). Those pathways were used for climate modeling. A decision support system (DSSAT) for agricultural production was used to assess the impact of climate changes on agricultural production. This approach was used for the Identification of climate change risk and their impacts on Agriculture. Outputs from models are used to assess the vulnerability of farmers and crops to climate and socio-economic change by estimating their sensitivity and capacity to adapt to external factors as a means of identifying what causes the differences in their vulnerability. Based on the projection models for the area, average temperature in Jordan is projected to increase between 1.2 and 1.6°C by 2050. These upward temperature trends are projected to continue beyond 2050. Projections for precipitation trends are projected to decrease by 16% by the year 2050. Evaporation is likely to increase due to higher temperatures. This is likely to increase the incidence of drought potential since precipitation is projected to decrease. It is concluded that the Overall vulnerability of agriculture to climate change in Jordan is high, where impacts such as drought and increased temperatures and decreased precipitation will be more pronounced. Major implications on rain fed agriculture are possible shorter growing season, increasing moisture and heat stress to field and horticultural crops and eventually low income and food insecurity. There were different impacts among studied communities, which is related to the: economic capability, local knowledge, physical infrastructure, institutional capacity, modern technology used, age group of farmers and diversification of their income.

Maternal age and offspring developmental vulnerability at age five: A population-based cohort study of Australian children

PubMed Central

Banks, Emily; Lynch, John; Brownell, Marni; Eades, Sandra; Jorm, Louisa

2018-01-01

Background In recent decades, there has been a shift to later childbearing in high-income countries. There is limited large-scale evidence of the relationship between maternal age and child outcomes beyond the perinatal period. The objective of this study is to quantify a child’s risk of developmental vulnerability at age five, according to their mother’s age at childbirth. Methods and findings Linkage of population-level perinatal, hospital, and birth registration datasets to data from the Australian Early Development Census (AEDC) and school enrolments in Australia’s most populous state, New South Wales (NSW), enabled us to follow a cohort of 99,530 children from birth to their first year of school in 2009 or 2012. The study outcome was teacher-reported child development on five domains measured by the AEDC, including physical health and well-being, emotional maturity, social competence, language and cognitive skills, and communication skills and general knowledge. Developmental vulnerability was defined as domain scores below the 2009 AEDC 10th percentile cut point. The mean maternal age at childbirth was 29.6 years (standard deviation [SD], 5.7), with 4,382 children (4.4%) born to mothers aged <20 years and 20,026 children (20.1%) born to mothers aged ≥35 years. The proportion vulnerable on ≥1 domains was 21% overall and followed a reverse J-shaped distribution according to maternal age: it was highest in children born to mothers aged ≤15 years, at 40% (95% CI, 32–49), and was lowest in children born to mothers aged between 30 years and ≤35 years, at 17%–18%. For maternal ages 36 years to ≥45 years, the proportion vulnerable on ≥1 domains increased to 17%–24%. Adjustment for sociodemographic characteristics significantly attenuated vulnerability risk in children born to younger mothers, while adjustment for potentially modifiable factors, such as antenatal visits, had little additional impact across all ages. Although the multi-agency linkage yielded a broad range of sociodemographic, perinatal, health, and developmental variables at the child’s birth and school entry, the study was necessarily limited to variables available in the source data, which were mostly recorded for administrative purposes. Conclusions Increasing maternal age was associated with a lesser risk of developmental vulnerability for children born to mothers aged 15 years to about 30 years. In contrast, increasing maternal age beyond 35 years was generally associated with increasing vulnerability, broadly equivalent to the risk for children born to mothers in their early twenties, which is highly relevant in the international context of later childbearing. That socioeconomic disadvantage explained approximately half of the increased risk of developmental vulnerability associated with younger motherhood suggests there may be scope to improve population-level child development through policies and programs that support disadvantaged mothers and children. PMID:29689098

On the Science-Policy Bridge: Do Spatial Heat Vulnerability Assessment Studies Influence Policy?

PubMed Central

Wolf, Tanja; Chuang, Wen-Ching; McGregor, Glenn

2015-01-01

Human vulnerability to heat varies at a range of spatial scales, especially within cities where there can be noticeable intra-urban differences in heat risk factors. Mapping and visualizing intra-urban heat vulnerability offers opportunities for presenting information to support decision-making. For example the visualization of the spatial variation of heat vulnerability has the potential to enable local governments to identify hot spots of vulnerability and allocate resources and increase assistance to people in areas of greatest need. Recently there has been a proliferation of heat vulnerability mapping studies, all of which, to varying degrees, justify the process of vulnerability mapping in a policy context. However, to date, there has not been a systematic review of the extent to which the results of vulnerability mapping studies have been applied in decision-making. Accordingly we undertook a comprehensive review of 37 recently published papers that use geospatial techniques for assessing human vulnerability to heat. In addition, we conducted an anonymous survey of the lead authors of the 37 papers in order to establish the level of interaction between the researchers as science information producers and local authorities as information users. Both paper review and author survey results show that heat vulnerability mapping has been used in an attempt to communicate policy recommendations, raise awareness and induce institutional networking and learning, but has not as yet had a substantive influence on policymaking or preventive action. PMID:26512681

Vulnerability mapping as a tool to manage the environmental impacts of oil and gas extraction.

PubMed

Esterhuyse, Surina; Sokolic, Frank; Redelinghuys, Nola; Avenant, Marinda; Kijko, Andrzej; Glazewski, Jan; Plit, Lisa; Kemp, Marthie; Smit, Ansie; Vos, A Tascha; von Maltitz, Michael J

2017-11-01

Various biophysical and socio-economic impacts may be associated with unconventional oil and gas (UOG) extraction. A vulnerability map may assist governments during environmental assessments, spatial planning and the regulation of UOG extraction, as well as decision-making around UOG extraction in fragile areas. A regional interactive vulnerability map was developed for UOG extraction in South Africa. This map covers groundwater, surface water, vegetation, socio-economics and seismicity as mapping themes, based on impacts that may emanate from UOG extraction. The mapping themes were developed using a normative approach, where expert input during the identification and classification of vulnerability indicators may increase the acceptability of the resultant map. This article describes the development of the interactive vulnerability map for South Africa, where UOG extraction is not yet allowed and where regulations are still being developed to manage this activity. The importance and policy implications of using vulnerability maps for managing UOG extraction impacts in countries where UOG extraction is planned are highlighted in this article.

Vulnerability mapping as a tool to manage the environmental impacts of oil and gas extraction

PubMed Central

Sokolic, Frank; Redelinghuys, Nola; Avenant, Marinda; Kijko, Andrzej; Glazewski, Jan; Plit, Lisa; Kemp, Marthie; Smit, Ansie; Vos, A. Tascha; von Maltitz, Michael J.

2017-01-01

Various biophysical and socio-economic impacts may be associated with unconventional oil and gas (UOG) extraction. A vulnerability map may assist governments during environmental assessments, spatial planning and the regulation of UOG extraction, as well as decision-making around UOG extraction in fragile areas. A regional interactive vulnerability map was developed for UOG extraction in South Africa. This map covers groundwater, surface water, vegetation, socio-economics and seismicity as mapping themes, based on impacts that may emanate from UOG extraction. The mapping themes were developed using a normative approach, where expert input during the identification and classification of vulnerability indicators may increase the acceptability of the resultant map. This article describes the development of the interactive vulnerability map for South Africa, where UOG extraction is not yet allowed and where regulations are still being developed to manage this activity. The importance and policy implications of using vulnerability maps for managing UOG extraction impacts in countries where UOG extraction is planned are highlighted in this article. PMID:29291094

A vulnerability paradox in the cross-national prevalence of post-traumatic stress disorder.

PubMed

Dückers, Michel L A; Alisic, Eva; Brewin, Chris R

2016-10-01

Determinants of cross-national differences in the prevalence of mental illness are poorly understood. To test whether national post-traumatic stress disorder (PTSD) rates can be explained by (a) rates of exposure to trauma and (b) countries' overall cultural and socioeconomic vulnerability to adversity. We collected general population studies on lifetime PTSD and trauma exposure, measured using the WHO Composite International Diagnostic Interview (DSM-IV). PTSD prevalence was identified for 24 countries (86 687 respondents) and exposure for 16 countries (53 038 respondents). PTSD was predicted using exposure and vulnerability data. PTSD is related positively to exposure but negatively to country vulnerability. Together, exposure, vulnerability and their interaction explain approximately 75% of variance in the national prevalence of PTSD. Contrary to expectations based on individual risk factors, we identified a paradox whereby greater country vulnerability is associated with a decreased, rather than increased, risk of PTSD for its citizens. © The Royal College of Psychiatrists 2016.

Grandiose and Vulnerable Narcissism, Materialism, Money Attitudes, and Consumption Preferences.

PubMed

Pilch, Irena; Górnik-Durose, Małgorzata E

2017-02-17

Narcissism is increasingly being investigated in the context of consumer attitudes and behavior. Previous research showed that narcissism is reflected in materialistic tendencies and money-related attitudes. However, almost all of these studies concerned the grandiose type of narcissism. We examined relationships of both grandiose and vulnerable narcissism with materialism, money attitudes, and consumption preferences in a nonstudent sample. The results showed that the two types of narcissism are equally associated with materialism and a tendency to conspicuous (public) consumption. Differences between grandiose and vulnerable narcissism with regard to money attitudes were observed. Materialism mediated most of the relationships between narcissism, money attitudes, and consumption preferences, but the patterns of mediation were different for grandiose and vulnerable subtypes. Mutual suppression occurred when grandiose narcissism and materialism predicted anxiety associated with money and when vulnerable narcissism and materialism predicted money perceived as a source of evil. The results suggested that not only grandiose, but also vulnerable narcissists may be prone to excessive consumption and that this can be explained by their materialistic tendencies.

Inclusive and relevant language: the use of the concepts of autonomy, dignity and vulnerability in different contexts.

PubMed

Haugen, Hans Morten

2010-08-01

The article analyses the three terms autonomy, dignity and vulnerability. The relevance and practical application of the terms is tested in two spheres. First, as guiding principles in the area of ethics of medicines and science. Second, as human rights principles, serving to guide the conduct of public policies for an effective realization of human rights. The article argues that all human beings have the same dignity, but that the autonomy--and therefore vulnerability--differs considerably. Simply said, with reduced autonomy comes increased vulnerability, implying extra attention to the protective dimensions. The article finds that the three terms approach the protection of human beings in different ways and that all are relevant and applicable in both spheres, but that an isolated notion of autonomy and a 'group-based' notion of vulnerability are not adequate.

Vulnerabilities, Influences and Interaction Paths: Failure Data for Integrated System Risk Analysis

NASA Technical Reports Server (NTRS)

Malin, Jane T.; Fleming, Land

2006-01-01

We describe graph-based analysis methods for identifying and analyzing cross-subsystem interaction risks from subsystem connectivity information. By discovering external and remote influences that would be otherwise unexpected, these methods can support better communication among subsystem designers at points of potential conflict and to support design of more dependable and diagnosable systems. These methods identify hazard causes that can impact vulnerable functions or entities if propagated across interaction paths from the hazard source to the vulnerable target. The analysis can also assess combined impacts of And-Or trees of disabling influences. The analysis can use ratings of hazards and vulnerabilities to calculate cumulative measures of the severity and importance. Identification of cross-subsystem hazard-vulnerability pairs and propagation paths across subsystems will increase coverage of hazard and risk analysis and can indicate risk control and protection strategies.

Perceived Vulnerability to Disease Predicts Environmental Attitudes

ERIC Educational Resources Information Center

Prokop, Pavol; Kubiatko, Milan

2014-01-01

Investigating predictors of environmental attitudes may bring valuable benefits in terms of improving public awareness about biodiversity degradation and increased pro-environmental behaviour. Here we used an evolutionary approach to study environmental attitudes based on disease-threat model. We hypothesized that people vulnerable to diseases may…

Vulnerabilities and adaptive capacities of southwest rangeland livestock production to climate change

USDA-ARS?s Scientific Manuscript database

The rangeland livestock industry across the southwestern US (California, Nevada, Arizona, Utah and New Mexico) consists of highly diverse production operations in these arid and semi-arid environments with low primary productivity. The vulnerabilities of this industry with projected increasing arid...

Predicting the relatiave vulnerability of near-coastal species to climate change using a rule-based ecoinformatics approach

EPA Science Inventory

Background/Questions/Methods Near-coastal species are threatened by multiple climate change drivers, including temperature increases, ocean acidification, and sea level rise. To identify vulnerable habitats, geographic regions, and species, we developed a sequential, rule-based...

Shared reality of the abusive and the vulnerable: the experience of aging for parents living with abusive adult children coping with mental disorder.

PubMed

Band-Winterstein, Tova; Smeloy, Yael; Avieli, Hila

2014-11-01

Increasing numbers of aging parents are finding themselves in the role of caregiver for their mentally ill adult child due to global deinstitutionalization policy. The aim of this paper is to describe the daily aging experience of parents abused by an adult child with mental disorder and the challenges confronting them in this shared reality. Data collection was performed through in-depth semi-structured interviews with 16 parents, followed by content analysis. Three major themes emerged: (a) old age as a platform for parent's vulnerability facing ongoing abuse; (b) "whose needs come first?" in a shared reality of abusive and vulnerable protagonists; (c) changes in relationship dynamics. Old age becomes an arena for redefined relationships combining increased vulnerability, needs of both sides, and its impact on the well-being of the aging parents. This calls for better insights and deeper understanding in regard to intervention with such families.

HIV and Mexican migrant workers in the United States: a review applying the vulnerable populations conceptual model.

PubMed

Albarrán, Cynthia R; Nyamathi, Adeline

2011-01-01

Mexican migrant workers residing in the United States are a vulnerable population at high risk for HIV infection. This article critically appraises the published data surrounding HIV prevalence in this vulnerable group, as seen through the lens of the Vulnerable Populations Conceptual Model. This model demonstrates how exposure to risk and resource availability affect health status. The health status of Mexican migrants in the United States is compromised by a number of factors that increase risk of HIV: limited access to health services, multiple sexual partners, low rates of condom use, men having sex with men, and lay injection practices. Migration from Mexico to the United States has increased the prevalence of HIV in rural Mexico, making this an issue of urgent binational concern. This review highlights the implications for further nursing research, practice, and policy. Copyright © 2011 Association of Nurses in AIDS Care. Published by Elsevier Inc. All rights reserved.

Vulnerability to typhoon hazards in the coastal informal settlements of Metro Manila, the Philippines.

PubMed

Morin, Véronique M; Ahmad, Mokbul Morshed; Warnitchai, Pennung

2016-10-01

In many low- and middle-income countries informal communities-also termed slum and squatter areas-have become a dominant and distinct form of urban settlement, with ever increasing populations. Such communities are often located in areas of high hazard exposure and frequently affected by disasters. While often recognised as one of the highest 'at risk' populations, this paper will argue that informal settlers have been directly and indirectly excluded from many formal mechanisms, thereby increasing their vulnerability to disaster events. Household surveys were conducted across several frequently flooded informal coastal communities in Metro Manila, the Philippines, following a major typhoon and storm surge disaster. The study revealed a large level of diversity in socio-economic vulnerability, although all households faced similar levels of physical exposure and physical vulnerability. Disaster risk reduction policies and responses need to better integrate informal settlement areas and recognise the diversity within these communities. © 2016 The Author(s). Disasters © Overseas Development Institute, 2016.

Fear of Ebola: The Influence of Collectivism on Xenophobic Threat Responses.

PubMed

Kim, Heejung S; Sherman, David K; Updegraff, John A

2016-07-01

In response to the Ebola scare in 2014, many people evinced strong fear and xenophobia. The present study, informed by the pathogen-prevalence hypothesis, tested the influence of individualism and collectivism on xenophobic response to the threat of Ebola. A nationally representative sample of 1,000 Americans completed a survey, indicating their perceptions of their vulnerability to Ebola, ability to protect themselves from Ebola (protection efficacy), and xenophobic tendencies. Overall, the more vulnerable people felt, the more they exhibited xenophobic responses, but this relationship was moderated by individualism and collectivism. The increase in xenophobia associated with increased vulnerability was especially pronounced among people with high individualism scores and those with low collectivism scores. These relationships were mediated by protection efficacy. State-level collectivism had the same moderating effect on the association between perceived vulnerability and xenophobia that individual-level value orientation did. Collectivism-and the set of practices and rituals associated with collectivistic cultures-may serve as psychological protection against the threat of disease. © The Author(s) 2016.

Neurobiology of Adolescent Substance Use and Addictive Behaviors: Prevention and Treatment Implications

PubMed Central

Hammond, Christopher J.; Mayes, Linda C.; Potenza, Marc N.

2015-01-01

Psychoactive substance and nonsubstance/behavioral addictions are major public health concerns associated with significant societal cost. Adolescence is a period of dynamic biologic, psychological, and behavioral changes. Adolescence is also associated with an increased risk for substance use and addictive disorders. During adolescence, developmental changes in neural circuitry of reward processing, motivation, cognitive control, and stress may contribute to vulnerability for increased levels of engagement in substance use and nonsubstance addictive behaviors. Current biologic models of adolescent vulnerability for addictions incorporate existing data on allostatic changes in function and structure of the midbrain dopaminergic system, stress-associated neuroplasticity, and maturational imbalances between cognitive control and reward reactivity. When characterizing adolescent vulnerability, identifying subgroups of adolescents at high risk for addictive behaviors is a major goal of the addiction field. Genetics, epigenetics, and intermediate phenotypes/endophenotypes may assist in characterizing children and adolescents at risk. Improved understanding of the neurobiology of adolescence and addiction vulnerability has the potential to refine screening, enhance prevention and intervention strategies, and inform public policy. PMID:25022184

Cumulative Vulnerability: A Case Study on intrafamilial violence, Drug Addiction and Adolescent Pregnancy.

PubMed

Miura, Paula Orchiucci; Passarini, Gislaine Martins Ricardo; Ferreira, Loraine Seixas; Paixão, Rui Alexandre Paquete; Tardivo, Leila Salomão de La Plata Cury; Barrientos, Dora Mariela Salcedo

2014-12-01

A pregnant adolescent's vulnerability increases when she is a victim of intrafamilial violence and drug addiction, which cause physical and biopsychosocial damage to the mother and her baby. Objective Present and analyze the case of an adolescent who is addicted to drugs, pregnant and the victim of lifelong intrafamilial violence. Method A case study based on a semi-structured interview conducted in the Obstetrics Emergency Unit at the Teaching Hospital of the University of São Paulo. The data were interpreted and analyzed using Content Analysis. Results intrafamilial violence experienced at the beginning of the adolescent's early relationships seriously affected her emotional maturity, triggering the development of psychopathologies and leaving her more susceptible to the use and abuse of alcohol and other drugs. The adolescent is repeating her history with her daughter, reproducing the cycle of violence. Conclusion Adolescent pregnancy combined with intrafamilial violence and drug addiction and multiplies the adolescent's psychosocial vulnerability increased the adolescent's vulnerability.

Spatial-explicit modeling of social vulnerability to malaria in East Africa

PubMed Central

2014-01-01

Background Despite efforts in eradication and control, malaria remains a global challenge, particularly affecting vulnerable groups. Despite the recession in malaria cases, previously malaria free areas are increasingly confronted with epidemics as a result of changing environmental and socioeconomic conditions. Next to modeling transmission intensities and probabilities, integrated spatial methods targeting the complex interplay of factors that contribute to social vulnerability are required to effectively reduce malaria burden. We propose an integrative method for mapping relative levels of social vulnerability in a spatially explicit manner to support the identification of intervention measures. Methods Based on a literature review, a holistic risk and vulnerability framework has been developed to guide the assessment of social vulnerability to water-related vector-borne diseases (VBDs) in the context of changing environmental and societal conditions. Building on the framework, this paper applies spatially explicit modeling for delineating homogeneous regions of social vulnerability to malaria in eastern Africa, while taking into account expert knowledge for weighting the single vulnerability indicators. To assess the influence of the selected indicators on the final index a local sensitivity analysis is carried out. Results Results indicate that high levels of malaria vulnerability are concentrated in the highlands, where immunity within the population is currently low. Additionally, regions with a lack of access to education and health services aggravate vulnerability. Lower values can be found in regions with relatively low poverty, low population pressure, low conflict density and reduced contributions from the biological susceptibility domain. Overall, the factors characterizing vulnerability vary spatially in the region. The vulnerability index reveals a high level of robustness in regard to the final choice of input datasets, with the exception of the immunity indicator which has a marked impact on the composite vulnerability index. Conclusions We introduce a conceptual framework for modeling risk and vulnerability to VBDs. Drawing on the framework we modeled social vulnerability to malaria in the context of global change using a spatially explicit approach. The results provide decision makers with place-specific options for targeting interventions that aim at reducing the burden of the disease amongst the different vulnerable population groups. PMID:25127688

Coastal vulnerability assessment of Puducherry coast, India using analytical hierarchical process

NASA Astrophysics Data System (ADS)

Mani Murali, R.; Ankita, M.; Amrita, S.; Vethamony, P.

2013-03-01

Increased frequency of natural hazards such as storm surge, tsunami and cyclone, as a consequence of change in global climate, is predicted to have dramatic effects on the coastal communities and ecosystems by virtue of the devastation they cause during and after their occurrence. The tsunami of December 2004 and the Thane cyclone of 2011 caused extensive human and economic losses along the coastline of Puducherry and Tamil Nadu. The devastation caused by these events highlighted the need for vulnerability assessment to ensure better understanding of the elements causing different hazards and to consequently minimize the after-effects of the future events. This paper advocates an Analytical Hierarchical Process (AHP) based approach to coastal vulnerability studies as an improvement to the existing methodologies for vulnerability assessment. The paper also encourages the inclusion of socio-economic parameters along with the physical parameters to calculate the coastal vulnerability index using AHP derived weights. Seven physical-geological parameters (slope, geomorphology, elevation, shoreline change, sea level rise, significant wave height and tidal range) and four socio-economic factors (population, Land-use/Land-cover (LU/LC), roads and location of tourist places) are considered to measure the Physical Vulnerability Index (PVI) as well as the Socio-economic Vulnerability Index (SVI) of the Puducherry coast. Based on the weights and scores derived using AHP, vulnerability maps are prepared to demarcate areas with very low, medium and high vulnerability. A combination of PVI and SVI values are further utilized to compute the Coastal Vulnerability Index (CVI). Finally, the various coastal segments are grouped into the 3 vulnerability classes to obtain the final coastal vulnerability map. The entire coastal extent between Muthiapet and Kirumampakkam as well as the northern part of Kalapet is designated as the high vulnerability zone which constitutes 50% of the coastline. The region between the southern coastal extent of Kalapet and Lawspet is the medium vulnerability zone and the rest 25% is the low vulnerability zone. The results obtained, enable to identify and prioritize the more vulnerable areas of the region to further assist the government and the residing coastal communities in better coastal management and conservation.

Coastal vulnerability assessment of Puducherry coast, India, using the analytical hierarchical process

NASA Astrophysics Data System (ADS)

Mani Murali, R.; Ankita, M.; Amrita, S.; Vethamony, P.

2013-12-01

As a consequence of change in global climate, an increased frequency of natural hazards such as storm surges, tsunamis and cyclones, is predicted to have dramatic affects on the coastal communities and ecosystems by virtue of the devastation they cause during and after their occurrence. The tsunami of December 2004 and the Thane cyclone of 2011 caused extensive human and economic losses along the coastline of Puducherry and Tamil Nadu. The devastation caused by these events highlighted the need for vulnerability assessment to ensure better understanding of the elements causing different hazards and to consequently minimize the after- effects of the future events. This paper demonstrates an analytical hierarchical process (AHP)-based approach to coastal vulnerability studies as an improvement to the existing methodologies for vulnerability assessment. The paper also encourages the inclusion of socio-economic parameters along with the physical parameters to calculate the coastal vulnerability index using AHP-derived weights. Seven physical-geological parameters (slope, geomorphology, elevation, shoreline change, sea level rise, significant wave height and tidal range) and four socio-economic factors (population, land use/land cover (LU/LC), roads and location of tourist areas) are considered to measure the physical vulnerability index (PVI) as well as the socio-economic vulnerability index (SVI) of the Puducherry coast. Based on the weights and scores derived using AHP, vulnerability maps are prepared to demarcate areas with very low, medium and high vulnerability. A combination of PVI and SVI values are further utilized to compute the coastal vulnerability index (CVI). Finally, the various coastal segments are grouped into the 3 vulnerability classes to obtain the coastal vulnerability map. The entire coastal extent between Muthiapet and Kirumampakkam as well as the northern part of Kalapet is designated as the high vulnerability zone, which constitutes 50% of the coastline. The region between the southern coastal extent of Kalapet and Lawspet is the medium vulnerability zone and the remaining 25% is the low vulnerability zone. The results obtained enable the identification and prioritization of the more vulnerable areas of the region in order to further assist the government and the residing coastal communities in better coastal management and conservation.

Vulnerable populations in healthcare.

PubMed

Waisel, David B

2013-04-01

This review is designed to update readers on recent discussions and research regarding vulnerable populations in medicine, including patients who are socioeconomically disadvantaged, queer, in prison or labeled with a stigmatizing complex medical disease. Recent studies have more closely examined the effects of being part of a vulnerable population. Greater societal income inequality impacts those at the lower end of the income curve by increasing mortality and heightening the importance of individual personal situations. Recommendations from an extensive WHO report on the social determinants of health may affect social policy and use of public resources in Europe. Clinicians are undereducated about the lives and concerns of vulnerable populations, including LGBTQI persons, immigrants, physicians, prisoners, and families of patients with diseases considered 'incompatible with life'. Greater understanding of the cause of the health effects of being socioeconomically disadvantaged or being a member of a vulnerable population may be the first steps toward specific policy recommendations. Professional medical organizations and advocacy groups should raise awareness, provide education, publish guidelines and define the goals for the medical care for certain vulnerable populations.Vulnerable populations are at risk for disparate healthcare access and outcomes because of economic, cultural, ethnic or health characteristics. Vulnerable populations include patients who are racial or ethnic minorities, children, elderly, socioeconomically disadvantaged, underinsured or those with certain medical conditions. Members of vulnerable populations often have health conditions that are exacerbated by unnecessarily inadequate healthcare.

Assessing the ecological vulnerability of the upper reaches of the Minjiang River.

PubMed

Zhang, Jifei; Sun, Jian; Ma, Baibing; Du, Wenpeng

2017-01-01

The upper reaches of the Minjiang River (URMR), located on the eastern edge of the Tibetan Plateau in southwestern China, are an important component of the ecological barrier of the Upper Yangtze River Basin. Climate change and human activities have increased the ecological sensitivity and vulnerability of the region, which may pose a threat to the ecological security of the Yangtze River Basin and have negative impacts on local social and economic development. In this study, we analyzed land use and cover change (LUCC) of the URMR between 2000 and 2010, and found that the total rate of LUCC was less than 0.50% during this period. In addition, net primary production (NPP) was employed to describe the changes in ecosystem sensitivity and vulnerability, and the results demonstrated that slightly and moderately sensitive and vulnerable zones occupied the largest area, distributed mainly in forest, shrub, and grassland ecosystems. However, compared with the period from 2000 to 2005, the ecological sensitivity and vulnerability showed a worsening trend in the period 2005-2010. Exploring the relationship between vulnerability/sensitivity and environmental factors, we found that sensitivity and vulnerability were positively correlated with precipitation (>700 mm) and aridity index (>36 mm/°C). The results highlight that the future ecological sensitivity and vulnerability of URMR should be further investigated, and that the LUCC induced by human activities and climate change have caused alteration of in ecosystem vulnerability.

Water supply, demand, and quality indicators for assessing the spatial distribution of water resource vulnerability in the Columbia River Basin

USGS Publications Warehouse

Chang, Heejun; Jung, Il-Won; Strecker, Angela L.; Wise, Daniel; Lafrenz, Martin; Shandas, Vivek; ,; Yeakley, Alan; Pan, Yangdong; Johnson, Gunnar; Psaris, Mike

2013-01-01

We investigated water resource vulnerability in the US portion of the Columbia River basin (CRB) using multiple indicators representing water supply, water demand, and water quality. Based on the US county scale, spatial analysis was conducted using various biophysical and socio-economic indicators that control water vulnerability. Water supply vulnerability and water demand vulnerability exhibited a similar spatial clustering of hotspots in areas where agricultural lands and variability of precipitation were high but dam storage capacity was low. The hotspots of water quality vulnerability were clustered around the main stem of the Columbia River where major population and agricultural centres are located. This multiple equal weight indicator approach confirmed that different drivers were associated with different vulnerability maps in the sub-basins of the CRB. Water quality variables are more important than water supply and water demand variables in the Willamette River basin, whereas water supply and demand variables are more important than water quality variables in the Upper Snake and Upper Columbia River basins. This result suggests that current water resources management and practices drive much of the vulnerability within the study area. The analysis suggests the need for increased coordination of water management across multiple levels of water governance to reduce water resource vulnerability in the CRB and a potentially different weighting scheme that explicitly takes into account the input of various water stakeholders.

The ethics and regulatory landscape of including vulnerable populations in pragmatic clinical trials.

PubMed

Welch, Mary Jane; Lally, Rachel; Miller, Jennifer E; Pittman, Stephanie; Brodsky, Lynda; Caplan, Arthur L; Uhlenbrauck, Gina; Louzao, Darcy M; Fischer, James H; Wilfond, Benjamin

2015-10-01

Policies have been developed to protect vulnerable populations in clinical research, including the US federal research regulations (45 Code of Federal Regulations 46 Subparts B, C, and D). These policies generally recognize vulnerable populations to include pregnant women, fetuses, neonates, children, prisoners, persons with physical handicaps or mental disabilities, and disadvantaged persons. The aim has been to protect these populations from harm, often by creating regulatory and ethical checks that may limit their participation in many clinical trials. The recent increase in pragmatic clinical trials raises at least two questions about this approach. First, is exclusion itself a harm to vulnerable populations, as these groups may be denied access to understanding how health interventions work for them in clinical settings? Second, are groups considered vulnerable in traditional clinical trials also vulnerable in pragmatic clinical trials? We argue first that excluding vulnerable subjects from participation in pragmatic clinical trials can be harmful by preventing acquisition of data to meaningfully inform clinical decision-making in the future. Second, we argue that protections for vulnerable subjects in traditional clinical trial settings may not be translatable, feasible, or even ethical to apply in pragmatic clinical trials. We conclude by offering specific recommendations for appropriately protecting vulnerable research subjects in pragmatic clinical trials, focusing on pregnant women, fetuses, neonates, children, prisoners, persons with physical handicaps or mental disabilities, and disadvantaged persons. © The Author(s) 2015.

Vulnerability of ground water to contamination, Edwards Aquifer recharge zone, Bexar County, Texas, 1998

USGS Publications Warehouse

Clark, Allan K.

2000-01-01

The Edwards aquifer, one of the most productive carbonate-rock aquifers in the Nation, is composed of the Kainer and Person Formations of the Edwards Group plus the overlying Georgetown Formation. Most recharge to the Edwards aquifer results from the percolation of streamflow loss and the infiltration of precipitation through porous parts of the recharge zone. Residential and commercial development is increasing, particularly in Bexar County in south-central Texas, atop the densely fractured and steeply faulted recharge zone. The increasing development has increased the vulnerability of ground water to contamination by spillage or leakage of waste materials, particularly fluids associated with urban runoff and (or) septic-tank leachate. This report describes a method of assessing the vulnerability of ground water to contamination in the Edwards aquifer recharge zone. The method is based on ratings of five natural features of the area: (1) hydraulic properties of outcropping hydrogeologic units; (2) presence or absence of faults; (3) presence or absence of caves and (or) sinkholes; (4) slope of land surface; and (5) permeability of soil. The sum of the ratings for the five natural features was used to develop a map showing the recharge zone's vulnerability to ground-water contamination.

Assessing the Vulnerability of Streams to Increased Frequency and Severity of Low Flows in the Southeastern United States

NASA Astrophysics Data System (ADS)

Konrad, C. P.

2014-12-01

A changing climate poses risks to the availability and quality of water resources. Among the risks, increased frequency and severity of low flow periods in streams would be significant for many in-stream and out-of-stream uses of water. While down-scaled climate projections serve as the basis for understanding impacts of climate change on hydrologic systems, a robust framework for risk assessment incorporates multiple dimensions of risks including the vulnerability of hydrologic systems to climate change impacts. Streamflow records from the southeastern US were examined to assess the vulnerability of streams to increased frequency and severity of low flows. Long-term (>50 years) records provide evidence of more frequent and severe low flows in more streams than would be expected from random chance. Trends in low flows appear to be a result of changes in the temporal distribution rather than the annual amount of preciptation and/or in evaporation. Base flow recession provides an indicator of a stream's vulnerability to such changes. Linkages between streamflow patterns across temporal scales can be used for understanding and asessing stream responses to the various possible expressions of a changing climate.

The frail elderly: a matter of caring.

PubMed

Erlen, Judith A

2007-01-01

Nurses caring for patients with orthopaedic problems often encounter elderly patients in their caseload. These patients have variable levels of functioning; some may be frail and, therefore, require greater assistance and possibly more time with their care. This loss of function and need for more assistance increases their vulnerability and creates challenges for nurses and other healthcare providers who are delivering patient care. This article offers a brief description of the frail elderly and examines their increasing vulnerability and their need for additional protection, preserving their dignity and respecting their autonomy, and how caring helps to guide nurses in addressing the special needs of this particularly vulnerable patient population. Sensitivity, patience, trust, compassion, and clinical competence matter when caring for the frail elderly.

Social vulnerability assessment: a growing practice in Europe?

NASA Astrophysics Data System (ADS)

Tapsell, S.; McC arthy, S.

2012-04-01

This paper builds upon work on social vulnerability from the CapHaz-Net consortium, an ongoing research project funded by the European Commission in its 7th Framework Programme. The project focuses on the social dimensions of natural hazards, as well as on regional practices of risk prevention and management, and aims at improving the resilience of European societies to natural hazards, paying particular attention to social capacity building. The topic of social vulnerability is one of seven themes being addressed in the project. There are various rationales for examining the relevance of social vulnerability to natural hazards. Vulnerability assessment has now been accepted as a requirement for the effective development of emergency management capability, and assessment of social vulnerability has been recognised as being integral to understanding the risk to natural hazards. The aim of our research was to examine social vulnerability, how it might be understood in the context of natural hazards in Europe, and how social vulnerability can be addressed to increase social capacity. The work comprised a review of research on social vulnerability to different natural hazards within Europe and included concepts and definitions of social vulnerability (and related concepts), the purpose of vulnerability assessment and who decides who is vulnerable, different approaches to assessing or measuring social vulnerability (such as the use of 'classical' quantitative vulnerability indicators and qualitative community-based approaches, along with the advantages and disadvantages of both), conceptual frameworks for assessing social vulnerability and three case studies of social vulnerability studies within Europe: flash floods in the Italian Alps, fluvial flooding in Germany and heat waves in Spain. The review reveals variable application of social vulnerability analysis across Europe and there are indications why this might be the case. Reasons could range from the scale of country policy and the particular risk management focus to the smaller scale risk management perceptions of the analysis techniques employed being to resource expensive, difficult to interpret or to operationalise. This paper will provide a context with some empirical examples to perhaps explain the growing popularity of concepts such as resilience and capacity building which lie more comfortably with policy makers and risk managers as concepts which focus on the solution rather than identifying a problem by assessing social vulnerability.

Cavitation resistance and seasonal hydraulics differ among three arid Californian plant communities.

PubMed

Jacobsen, Anna L; Pratt, R Brandon; Davis, Stephen D; Ewers, Frank W

2007-12-01

Vulnerability to water stress-induced cavitation was measured on 27 woody shrub species from three arid plant communities including chaparral, coastal sage and Mojave Desert scrub. Dry season native embolism and pre-dawn water potential, and both wet and dry season xylem specific hydraulic conductivity (Ks) were measured. Cavitation resistance, estimated as water potential at 50% loss in conductivity (Psi50), was measured on all species during the wet season and on a subset of species during the dry season. Cavitation resistance varied with sampling season, with 8 of 13 sampled species displaying significant seasonal shifts. Native embolism and water potential were useful in identification of species displaying seasonal shifts. The Ks was not different among sites or seasons. The Psi50 varied among species and communities. Within communities, interspecific variation may be partially explained by differences in rooting depth or leaf habit (evergreen, semi-deciduous, deciduous). Communities diverged in their Psi50 with chaparral species displaying the greatest cavitation resistance regardless of sampling season. The greater cavitation resistance of chaparral species is surprising, considering the greater aridity of the Mojave Desert site. Adaptation to arid environments is due to many plant traits, and aridity does not necessarily lead to convergence in cavitation resistance.

Adolescent Social Isolation as a Model of Heightened Vulnerability to Comorbid Alcoholism and Anxiety Disorders.

PubMed

Butler, Tracy R; Karkhanis, Anushree N; Jones, Sara R; Weiner, Jeffrey L

2016-06-01

Individuals diagnosed with anxiety-related illnesses are at increased risk of developing alcoholism, exhibit a telescoped progression of this disease and fare worse in recovery, relative to alcoholics that do not suffer from a comorbid anxiety disorder. Similarly, preclinical evidence supports the notion that stress and anxiety represent major risk factors for the development of alcohol use disorder (AUD). Despite the importance of understanding the link between anxiety and alcoholism, much remains unknown about the neurobiological substrates underlying this relationship. One stumbling block has been the lack of animal models that reliably reproduce the spectrum of behaviors associated with increased vulnerability to these diseases. Here, we review the literature that has examined the behavioral and neurobiological outcomes of a simple rodent adolescent social isolation procedure and discuss its validity as a model of vulnerability to comorbid anxiety disorders and alcoholism. Recent studies have provided strong evidence that adolescent social isolation of male rats leads to the expression of a variety of behaviors linked with increased vulnerability to anxiety and/or AUD, including deficits in sensory gating and fear extinction, and increases in anxiety measures and ethanol drinking. Neurobiological studies are beginning to identify mesolimbic adaptations that may contribute to the behavioral phenotype engendered by this model. Some of these changes include increased excitability of ventral tegmental area dopamine neurons and pyramidal cells in the basolateral amygdala and significant alterations in baseline and stimulated catecholamine signaling. A growing body of evidence suggests that adolescent social isolation may represent a reliable rodent model of heightened vulnerability to anxiety disorders and alcoholism in male rats. These studies provide initial support for the face, construct, and predictive validity of this model and highlight its utility in identifying neurobiological adaptations associated with increased risk of developing these disorders. Copyright © 2016 by the Research Society on Alcoholism.

Psychological vulnerability to daily stressors in old age: Results of short-term longitudinal studies.

PubMed

Schilling, Oliver Karl; Diehl, Manfred

2015-08-01

A growing numbers of intensive longitudinal studies examine the short-term variability of behavior in response to daily stressors. Collectively, these studies address the vulnerability for stress-related emotional burden as assessed in terms of the intraindividual association between daily stressors and negative affect (NA). This article provides a brief overview of the relevant research on so-called affective reactivity to daily stressors and focuses on findings on development of age-related stressor reactivity across the adult lifespan. Two theoretical propositions have been put forward. Firstly, it has been postulated that aging should be associated with increased affective reactivity, i.e. it has been assumed that the vulnerability in terms of physiological stress reactivity increases across the adult life span and, thus, a higher stress-induced emotional reactivity should result with increasing age. Secondly, it has been argued that due to the continued development of emotional self-regulation skills, there should be an age-related decrease in stress reactivity and, hence, an increased resilience. Findings on age differences in NA reactivity to daily stressors, however, have been inconsistent. A possible explanation for the inconsistent findings may lie in the fact that the postulated dynamics of increased vulnerability or resilience imply different time-related reactions to stressors. In particular, the activation and effectiveness of emotional self-regulation strategies increase with increasing time intervals from the stressors. This leads to the conclusion that with increasing age the resilience for longer periods of stress and accumulated stress should increase. Results from our own research support this hypothesis, where older adults reacted to multiple stressors in a more adaptive way than younger adults.

Assessing intrinsic and specific vulnerability models ability to indicate groundwater vulnerability to groups of similar pesticides: A comparative study

USGS Publications Warehouse

Douglas, Steven; Dixon, Barnali; Griffin, Dale W.

2018-01-01

With continued population growth and increasing use of fresh groundwater resources, protection of this valuable resource is critical. A cost effective means to assess risk of groundwater contamination potential will provide a useful tool to protect these resources. Integrating geospatial methods offers a means to quantify the risk of contaminant potential in cost effective and spatially explicit ways. This research was designed to compare the ability of intrinsic (DRASTIC) and specific (Attenuation Factor; AF) vulnerability models to indicate groundwater vulnerability areas by comparing model results to the presence of pesticides from groundwater sample datasets. A logistic regression was used to assess the relationship between the environmental variables and the presence or absence of pesticides within regions of varying vulnerability. According to the DRASTIC model, more than 20% of the study area is very highly vulnerable. Approximately 30% is very highly vulnerable according to the AF model. When groundwater concentrations of individual pesticides were compared to model predictions, the results were mixed. Model predictability improved when concentrations of the group of similar pesticides were compared to model results. Compared to the DRASTIC model, the AF model more accurately predicts the distribution of the number of contaminated wells within each vulnerability class.

Heat Wave Vulnerability Mapping for India.

PubMed

Azhar, Gulrez; Saha, Shubhayu; Ganguly, Partha; Mavalankar, Dileep; Madrigano, Jaime

2017-03-30

Assessing geographic variability in heat wave vulnerability forms the basis for planning appropriate targeted adaptation strategies. Given several recent deadly heatwaves in India, heat is increasingly being recognized as a public health problem. However, to date there has not been a country-wide assessment of heat vulnerability in India. We evaluated demographic, socioeconomic, and environmental vulnerability factors and combined district level data from several sources including the most recent census, health reports, and satellite remote sensing data. We then applied principal component analysis (PCA) on 17 normalized variables for each of the 640 districts to create a composite Heat Vulnerability Index (HVI) for India. Of the total 640 districts, our analysis identified 10 and 97 districts in the very high and high risk categories (> 2SD and 2-1SD HVI) respectively. Mapping showed that the districts with higher heat vulnerability are located in the central parts of the country. On examination, these are less urbanized and have low rates of literacy, access to water and sanitation, and presence of household amenities. Therefore, we concluded that creating and mapping a heat vulnerability index is a useful first step in protecting the public from the health burden of heat. Future work should incorporate heat exposure and health outcome data to validate the index, as well as examine sub-district levels of vulnerability.

M13 bacteriophage coat proteins engineered for improved phage display.

PubMed

Sidhu, Sachdev S; Feld, Birte K; Weiss, Gregory A

2007-01-01

This chapter describes a method for increasing levels of protein fusions displayed on the surfaces of M13 bacteriophage particles. By introducing mutations into the anchoring M13 coat protein, protein display levels can be increased by up to two orders of magnitude. Experimental methods are presented for the design, construction, and screening of phage-displayed libraries for improved protein display.

Quantitative Assessment of Transportation Network Vulnerability with Dynamic Traffic Simulation Methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shekar, Venkateswaran; Fiondella, Lance; Chatterjee, Samrat

Transportation networks are critical to the social and economic function of nations. Given the continuing increase in the populations of cities throughout the world, the criticality of transportation infrastructure is expected to increase. Thus, it is ever more important to mitigate congestion as well as to assess the impact disruptions would have on individuals who depend on transportation for their work and livelihood. Moreover, several government organizations are responsible for ensuring transportation networks are available despite the constant threat of natural disasters and terrorist activities. Most of the previous transportation network vulnerability research has been performed in the context ofmore » static traffic models, many of which are formulated as traditional optimization problems. However, transportation networks are dynamic because their usage varies over time. Thus, more appropriate methods to characterize the vulnerability of transportation networks should consider their dynamic properties. This paper presents a quantitative approach to assess the vulnerability of a transportation network to disruptions with methods from traffic simulation. Our approach can prioritize the critical links over time and is generalizable to the case where both link and node disruptions are of concern. We illustrate the approach through a series of examples. Our results demonstrate that the approach provides quantitative insight into the time varying criticality of links. Such an approach could be used as the objective function of less traditional optimization methods that use simulation and other techniques to evaluate the relative utility of a particular network defense to reduce vulnerability and increase resilience.« less

Spatial vulnerability of Australian urban populations to extreme heat events

NASA Astrophysics Data System (ADS)

Loughnan, Margaret; Tapper, Nigel; Phan, Thu; Lynch, Kellie; McInnes, Judith

2013-04-01

Extreme heat events pose a risk to the health of all individuals, especially the elderly and the chronically ill, and are associated with an increased demand for healthcare services. In order to address this problem, policy makers' need information about temperatures above which mortality and morbidity of the exposed population is likely to increase, where the vulnerable groups in the community are located, and how the risks from extreme heat events are likely to change in the future. This study identified threshold temperatures for all Australian capital cities, developed a spatial index of population vulnerability, and used climate model output to predict changes in the number of days exceeding temperature thresholds in the future, as well as changes in risk related to changes in urban density and an ageing population. The study has shown that daily maximum and minimum temperatures from the Bureau of Meteorology forecasts can be used to calculate temperature thresholds for heat alert days. The key risk factors related to adverse health outcomes were found to be areas with intense urban heat islands, areas with higher proportions of older people, and areas with ethnic communities. Maps of spatial vulnerability have been developed to provide information to assist emergency managers, healthcare professionals, and ancillary services develop heatwave preparedness plans at a local scale that target vulnerable groups and address heat-related health risks. The numbers of days exceeding current heat thresholds are predicted to increase over the next 20 to 40 years in all Australian capital cities.

Embryonic background risk promotes the survival of tadpoles facing surface predators

PubMed Central

Chivers, Douglas P.; Ferrari, Maud C. O.

2018-01-01

Exposure to intense predation risk can induce morphological and behavioural phenotypes that prepare prey, often at young ages, for surviving attacks from unknown predators. However, previous studies revealed that this survival advantage depended on the predator species. Here, we used alarm cues from injured conspecifics to simulate a period of high predation risk for embryonic wood frogs, Lithobates sylvaticus. Two weeks post-hatching, we tested whether the embryonic risk exposure influenced survival in encounters with two novel predators: (1) a spider (Dolomedes sp.) that ambushes prey exclusively on the surface of the water, and (2) the adult predacious diving beetle (Dytiscus sp.) which displays underwater sit-and-wait posture and pursuit tactics. Tadpoles exposed to embryonic high-risk survived longer when encountering spiders, whereas background risk had no influence on survival with adult beetles. These findings, coupled with survival studies involving other predator types, indicate that a high-risk environment promotes tadpole survival in future encounters with unknown sit-and-wait predators, but at the cost of increased vulnerability to novel predators capable of active pursuit. PMID:29561913

Adrenocortical stress responses influence an invasive vertebrate's fitness in an extreme environment

PubMed Central

Jessop, Tim S.; Letnic, Mike; Webb, Jonathan K.; Dempster, Tim

2013-01-01

Continued range expansion into physiologically challenging environments requires invasive species to maintain adaptive phenotypic performance. The adrenocortical stress response, governed in part by glucocorticoid hormones, influences physiological and behavioural responses of vertebrates to environmental stressors. However, any adaptive role of this response in invasive populations that are expanding into extreme environments is currently unclear. We experimentally manipulated the adrenocortical stress response of invasive cane toads (Rhinella marina) to investigate its effect on phenotypic performance and fitness at the species' range front in the Tanami Desert, Australia. Here, toads are vulnerable to overheating and dehydration during the annual hot–dry season and display elevated plasma corticosterone levels indicative of severe environmental stress. By comparing unmanipulated control toads with toads whose adrenocortical stress response was manipulated to increase acute physiological stress responsiveness, we found that control toads had significantly reduced daily evaporative water loss and higher survival relative to the experimental animals. The adrenocortical stress response hence appears essential in facilitating complex phenotypic performance and setting fitness trajectories of individuals from invasive species during range expansion. PMID:23945686

Resistance to BET Inhibitor Leads to Alternative Therapeutic Vulnerabilities in Castration-Resistant Prostate Cancer.

PubMed

Pawar, Aishwarya; Gollavilli, Paradesi Naidu; Wang, Shaomeng; Asangani, Irfan A

2018-02-27

BRD4 plays a major role in the transcription networks orchestrated by androgen receptor (AR) in castration-resistant prostate cancer (CRPC). Several BET inhibitors (BETi) that displace BRD4 from chromatin are being evaluated in clinical trials for CRPC. Here, we describe mechanisms of acquired resistance to BETi that are amenable to targeted therapies in CRPC. BETi-resistant CRPC cells displayed cross-resistance to a variety of BETi in the absence of gatekeeper mutations, exhibited reduced chromatin-bound BRD4, and were less sensitive to BRD4 degraders/knockdown, suggesting a BRD4-independent transcription program. Transcriptomic analysis revealed reactivation of AR signaling due to CDK9-mediated phosphorylation of AR, resulting in sensitivity to CDK9 inhibitors and enzalutamide. Additionally, increased DNA damage associated with PRC2-mediated transcriptional silencing of DDR genes was observed, leading to PARP inhibitor sensitivity. Collectively, our results identify the therapeutic limitation of BETi as a monotherapy; however, our BETi resistance data suggest unique opportunities for combination therapies in treating CRPC. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

Oxidative Capacity and Fatigability in Run Trained Malignant Hyperthermia Susceptible Mice

PubMed Central

Rouviere, Clement; Corona, Benjamin T.; Ingalls, Christopher P.

2011-01-01

Introduction The purpose of this study was to test the hypothesis that Malignant Hyperthermia model mice (RyR1Y522S/wt) are more vulnerable to exercise-induced muscle injury and fatigability and adapt less to run training. Methods Following 6 weeks of voluntary wheel running, we measured anterior crural muscle fatigability, muscle injury, and cytochrome oxidase (COX) and citrate synthase (CS). Results Although RyR1Y522S/wt mice ran without experiencing MH episodes, they ran 42% less distance than wild type (WT) mice. Muscles from WT mice exhibited increased fatigue resistance and COX content after training. Muscles from RyR1Y522S/wt mice demonstrated no significant change in fatigability or COX and CS after training. However, muscles from RyR1Y522S/wt mice displayed less intrinsic fatigability and greater COX/CS content and muscle damage than WT mice. Discussion RyR1Y522S/wt mice can run without experiencing rhabdomyolysis, and their inability to adapt to training appears to stem from intrinsic enhancement of mitochondrial enzymes and fatigue resistance. PMID:22431093

Oxidative capacity and fatigability in run-trained malignant hyperthermia-susceptible mice.

PubMed

Rouviere, Clement; Corona, Benjamin T; Ingalls, Christopher P

2012-04-01

The purpose of this study was to test the hypothesis that malignant hyperthermia model mice (RyR1Y522S/wt) are more vulnerable to exercise-induced muscle injury and fatigability and adapt less to run training. After 6 weeks of voluntary wheel running, we measured anterior crural muscle fatigability, muscle injury, and cytochrome oxidase (COX) and citrate synthase (CS). Although RyR1Y522S/wt mice ran without undergoing MH episodes, they ran 42% less distance than wild-type (WT) mice. Muscles from WT mice exhibited increased fatigue resistance and COX content after training. Muscles from RyR1Y522S/wt mice demonstrated no significant change in fatigability or COX and CS after training. However, muscles from RyR1Y522S/wt mice displayed less intrinsic fatigability and greater COX/CS content and muscle damage than WT mice. RyR1Y522S/wt mice can run without having rhabdomyolysis, and their inability to adapt to training appears to stem from intrinsic enhancement of mitochondrial enzymes and fatigue resistance. Copyright © 2012 Wiley Periodicals, Inc.

Intergenerational Transmission of Sexual Victimization Vulnerability as Mediated via Parenting

ERIC Educational Resources Information Center

Testa, Maria; Hoffman, Joseph H.; Livingston, Jennifer A.

2011-01-01

Objectives: Previous research suggests that women's early sexual victimization experiences may influence their parenting behaviors and increase the vulnerability of their children to being sexually victimized. The current study considered whether mother's sexual victimization experiences, in childhood and after age 14, were associated with the…

Climate change risks to United States infrastructure: impacts on coastal development, roads, bridges, and urban drainage

EPA Science Inventory

Changes in temperature, precipitation, sea level, and coastal storms will likely increase the vulnerability of infrastructure across the United States. Using four models of vulnerability, impacts, and adaptation of infrastructure, its deployment, and its role in protecting econom...

"Too Withdrawn" or "Too Friendly": Considering Social Vulnerability in Two Neuro-Developmental Disorders

ERIC Educational Resources Information Center

Jawaid, A.; Riby, D. M.; Owens, J.; White, S. W.; Tarar, T.; Schulz, P. E.

2012-01-01

In some neuro-developmental disorders, the combined effect of intellectual disability and atypicalities of social cognition may put individuals at increased vulnerability in their social environment. The neuro-developmental disorders Williams syndrome, characterised by "hypersociability", and autism spectrum disorders, characterised by "social…

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

PubMed Central

Akundi, Ravi S.; Huang, Zhenyu; Eason, Joshua; Pandya, Jignesh D.; Zhi, Lianteng; Cass, Wayne A.; Sullivan, Patrick G.; Büeler, Hansruedi

2011-01-01

Background PTEN-induced kinase 1 (PINK1) is linked to recessive Parkinsonism (EOPD). Pink1 deletion results in impaired dopamine (DA) release and decreased mitochondrial respiration in the striatum of mice. To reveal additional mechanisms of Pink1-related dopaminergic dysfunction, we studied Ca2+ vulnerability of purified brain mitochondria, DA levels and metabolism and whether signaling pathways implicated in Parkinson's disease (PD) display altered activity in the nigrostriatal system of Pink1−/− mice. Methods and Findings Purified brain mitochondria of Pink1−/− mice showed impaired Ca2+ storage capacity, resulting in increased Ca2+ induced mitochondrial permeability transition (mPT) that was rescued by cyclosporine A. A subpopulation of neurons in the substantia nigra of Pink1−/− mice accumulated phospho-c-Jun, showing that Jun N-terminal kinase (JNK) activity is increased. Pink1−/− mice 6 months and older displayed reduced DA levels associated with increased DA turnover. Moreover, Pink1−/− mice had increased levels of IL-1β, IL-12 and IL-10 in the striatum after peripheral challenge with lipopolysaccharide (LPS), and Pink1−/− embryonic fibroblasts showed decreased basal and inflammatory cytokine-induced nuclear factor kappa-β (NF-κB) activity. Quantitative transcriptional profiling in the striatum revealed that Pink1−/− mice differentially express genes that (i) are upregulated in animals with experimentally induced dopaminergic lesions, (ii) regulate innate immune responses and/or apoptosis and (iii) promote axonal regeneration and sprouting. Conclusions Increased mitochondrial Ca2+ sensitivity and JNK activity are early defects in Pink1−/− mice that precede reduced DA levels and abnormal DA homeostasis and may contribute to neuronal dysfunction in familial PD. Differential gene expression in the nigrostriatal system of Pink1−/− mice supports early dopaminergic dysfunction and shows that Pink1 deletion causes aberrant expression of genes that regulate innate immune responses. While some differentially expressed genes may mitigate neurodegeneration, increased LPS-induced brain cytokine expression and impaired cytokine-induced NF-κB activation may predispose neurons of Pink1−/− mice to inflammation and injury-induced cell death. PMID:21249202

Long-term increase in coherence between the basal ganglia and motor cortex after asphyxial cardiac arrest and resuscitation in developing rats.

PubMed

Aravamuthan, Bhooma R; Shoykhet, Michael

2015-10-01

The basal ganglia are vulnerable to injury during cardiac arrest. Movement disorders are a common morbidity in survivors. Yet, neuronal motor network changes post-arrest remain poorly understood. We compared function of the motor network in adult rats that, during postnatal week 3, underwent 9.5 min of asphyxial cardiac arrest (n = 9) or sham intervention (n = 8). Six months after injury, we simultaneously recorded local field potentials (LFP) from the primary motor cortex (MCx) and single neuron firing and LFP from the rat entopeduncular nucleus (EPN), which corresponds to the primate globus pallidus pars interna. Data were analyzed for firing rates, power, and coherence between MCx and EPN spike and LFP activity. Cardiac arrest survivors display chronic motor deficits. EPN firing rate is lower in cardiac arrest survivors (19.5 ± 2.4 Hz) compared with controls (27.4 ± 2.7 Hz; P < 0.05). Cardiac arrest survivors also demonstrate greater coherence between EPN single neurons and MCx LFP (3-100 Hz; P < 0.001). This increased coherence indicates abnormal synchrony in the neuronal motor network after cardiac arrest. Increased motor network synchrony is thought to be antikinetic in primary movement disorders. Characterization of motor network synchrony after cardiac arrest may help guide management of post-hypoxic movement disorders.

Can we "apply" the findings of Forster and Lavie (2008)? On the generalizability of attentional capture effects under varying levels of perceptual load.

PubMed

Lleras, Alejandro; Chu, Hengqing; Buetti, Simona

2017-06-01

Perceptual Load theory states that the degree of perceptual load on a display determines the amount of leftover attentional resources that the system can use to process distracting information. An important corollary of this theory is that the amount of perceptual load determines the vulnerability of the attention system to being captured by completely irrelevant stimuli, predicting larger amounts of capture with low perceptual load than with high perceptual load. This prediction was first confirmed by Forster and Lavie (2008). Here, we report 6 experiments that followed up on those earlier results, where we find that in many cases, the opposite pattern is obtained: attentional capture increased with increasing perceptual load. Given the lack of generalizability of the theory to new experimental contexts with fairly minor methodological differences, we conclude that Perceptual Load may not be a useful framework for understanding attentional capture. The theoretical and applied importance of these findings is discussed. In particular, we caution against using this theory in applied tasks and settings because best-use recommendations stemming from this theory regarding strategies to decrease distractibility may in fact produce the opposite effect: an increase in distractibility (with distractibility being indexed by the magnitude of the capture effect). (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Departure from the onset-onset rule.

PubMed

Chow, S L

1994-09-01

Using a signal-detection task, the generality of Turvey's (1973) onset-onset rule was tested in our experiments. After seeing, in succession, (1) one or two letters (target display), (2) a multiletter detection display, and (3) a mask display, subjects decided whether or not the letter or letters in the target display reappeared in the succeeding detection display at different levels of detection-display duration in various situations. The subjects' sensitivity was inconsistent with the onset-onset rule. More specifically, sensitivity increased with increases in display duration within a fixed stimulus onset asynchrony of 150 msec. Display duration, however, had no effect on response bias. Nor was there any interaction between display duration and display size in terms of either sensitivity or response bias. The more complicated relationship between display duration and display size does not invalidate the departure from the onset-onset rule.

Energy vulnerability relationships

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaw, B.R.; Boesen, J.L.

The US consumption of crude oil resources has been a steadily growing indicator of the vitality and strength of the US economy. At the same time import diversity has also been a rapidly developing dimension of the import picture. In the early 1970`s, embargoes of crude oil from Organization of Producing and Exporting Countries (OPEC) created economic and political havoc due to a significant lack of diversity and a unique set of economic, political and domestic regulatory circumstances. The continued rise of imports has again led to concerns over the security of our crude oil resource but threats to thismore » system must be considered in light of the diversity and current setting of imported oil. This report develops several important issues concerning vulnerability to the disruption of oil imports: (1) The Middle East is not the major supplier of oil to the United States, (2) The US is not vulnerable to having its entire import stream disrupted, (3) Even in stable countries, there exist vulnerabilities to disruption of the export stream of oil, (4) Vulnerability reduction requires a focus on international solutions, and (5) DOE program and policy development must reflect the requirements of the diverse supply. Does this increasing proportion of imported oil create a {open_quotes}dependence{close_quotes}? Does this increasing proportion of imported oil present a vulnerability to {open_quotes}price shocks{close_quotes} and the tremendous dislocations experienced during the 1970`s? Finally, what is the vulnerability of supply disruptions from the current sources of imported oil? If oil is considered to be a finite, rapidly depleting resource, then the answers to these questions must be {open_quotes}yes.{close_quotes} However, if the supply of oil is expanding, and not limited, then dependence is relative to regional supply sources.« less

Cognitive Impairment, Vulnerability, and Mortality Post Ischemic Stroke: A Five-Year Follow-Up of the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) Cohort.

PubMed

Gaynor, Eva; Rohde, Daniela; Large, Margaret; Mellon, Lisa; Hall, Patricia; Brewer, Linda; Conway, Orla; Hickey, Anne; Bennett, Kathleen; Dolan, Eamon; Callaly, Elizabeth; Williams, David

2018-05-23

The aim of this study was to examine predictors of mortality in patients 5 years after ischemic stroke, focusing on cognitive impairment, vulnerability, and vascular risk factors assessed at 6 months post stroke. Patients from the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) cohort were followed up 5 years post ischemic stroke. Vascular risk factors, cognitive impairment, and vulnerability were assessed at 6 months post stroke. Cognitive impairment was assessed using a cutoff score lower than 26 on the Montreal Cognitive Assessment (MoCA). Vulnerability was defined as a score of 3 or higher on the Vulnerable Elders Scale (VES). Mortality and date of death were ascertained using hospital records, death notifications, and contact with general practitioners. Predictors of mortality were explored using multivariate Cox proportional hazards models. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) are presented. Sixty-three of 256 patients (24.6%) assessed at 6 months post stroke had died within 5 years. Cognitive impairment (HR [95% CI]: 2.19 [1.42-3.39]), vulnerability (HR [95% CI]: 5.23 [2.92-9.36]), atrial fibrillation (AF) (HR [95% CI]: 2.31 [1.80-2.96]), and dyslipidemia (HR [95% CI]: 1.90 [1.10-3.27]) were associated with increased risk of 5-year mortality. Vulnerability, cognitive impairment, AF, and dyslipidemia at 6 months were associated with increased risks of mortality 5 years post ischemic stroke. Identification and management of these risk factors should be emphasized in poststroke care. Copyright © 2018 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Human vulnerability in volcanic environments: the case of Furnas, São Miguel, Azores

NASA Astrophysics Data System (ADS)

Dibben, Christopher; Chester, David K.

1999-09-01

The need to examine the vulnerability of people to natural hazards, in addition to the long-established requirement to study extreme events of nature, is being increasingly recognised within disaster research. Following a discussion of the nature of human vulnerability, we propose a framework for its analysis within the context of volcanic activity and we exemplify our approach by a detailed study of Furnas, a village located at the centre of a volcano with the same name on the island of São Miguel in the Azores. The methods used included in-depth interviews with permanent residents ( n=50), analysis of census records and an examination of the socio-economic history of the town. The vulnerability of an individual to volcanic hazards involves a complex interaction of elements which, in addition to the usual factors taken into account in programmes of hazard reduction (e.g., the nature of the physical threat, location and economic situation), also comprises his or her social context and a number of physiological and psychological considerations. It is argued, further, that both generally and in the case of Furnas, the root causes of vulnerability lie in the history and development of society. Individual decision making is fundamental but takes place within and cannot be separated from this social context. Vulnerability analysis allows the identification of points where intervention may be successful in reducing the likelihood of suffering in a society. It avoids the problem of people's unexpected reactions to invention leading to a changing or even increasing level of vulnerability, by studying society rather than just one aspect of volcanic hazard in isolation.

Assessing the vulnerability of infrastructure to climate change on the Islands of Samoa

NASA Astrophysics Data System (ADS)

Fakhruddin, S. H. M.

2015-03-01

Pacific Islanders have been exposed to risks associated with climate change. Samoa as one of the Pacific Islands are prone to climatic hazards that will likely increase in coming decades, affecting coastal communities and infrastructure around the islands. Climate models do not predict a reduction of such disaster events in the future in Samoa; indeed, most predict an increase in such events. This paper identifies key infrastructure and their functions and status in order to provide an overall picture of relative vulnerability to climate-related stresses of such infrastructure on the island. By reviewing existing reports as well as holding a series of consultation meetings, a list of critical infrastructures were developed and shared with stakeholders for their consideration. An indicator-based vulnerability model (SIVM) was developed in collaboration with stakeholders to assess the vulnerability of selected infrastructure systems on the Samoan Islands. Damage costs were extracted from the Evan cyclone recovery needs document. On the other hand, criticality and capacity to repair data were collected from stakeholders. Having stakeholder perspectives on these two issues was important because (a) criticality of a given infrastructure could be viewed differently among different stakeholders, and (b) stakeholders were the best available source (in this study) to estimate the capacity to repair non-physical damage to such infrastructure. Analysis of the results suggested rankings from most vulnerable to least vulnerable sectors are the transportation sector, the power sector, the water supply sector and the sewerage system.

Assessing the vulnerability of infrastructure to climate change on the Islands of Samoa

NASA Astrophysics Data System (ADS)

Fakhruddin, S. H. M.; Babel, M. S.; Kawasaki, A.

2015-06-01

Pacific Islanders have been exposed to risks associated with climate change. Samoa, as one of the Pacific Islands, is prone to climatic hazards that will likely increase in the coming decades, affecting coastal communities and infrastructure around the islands. Climate models do not predict a reduction of such disaster events in the future in Samoa; indeed, most predict an increase. This paper identifies key infrastructure and their functions and status in order to provide an overall picture of relative vulnerability to climate-related stresses of such infrastructure on the island. By reviewing existing reports as well as holding a series of consultation meetings, a list of critical infrastructure was developed and shared with stakeholders for their consideration. An indicator-based vulnerability model (SIVM) was developed in collaboration with stakeholders to assess the vulnerability of selected infrastructure systems on the Samoan Islands. Damage costs were extracted from the Cyclone Evan recovery needs document. Additionally, data on criticality and capacity to repair damage were collected from stakeholders. Having stakeholder perspectives on these two issues was important because (a) criticality of a given infrastructure could be viewed differently among different stakeholders, and (b) stakeholders were the best available source (in this study) to estimate the capacity to repair non-physical damage to such infrastructure. Analysis of the results suggested a ranking of sectors from the most vulnerable to least vulnerable are: the transportation sector, the power sector, the water supply sector and the sewerage system.

Individual vulnerabilities relative for potential pathological conditions.

PubMed

Moal, Michel Le

2016-08-15

It is not a usual venture to review experiments conducted decades ago in the context of interests of that time and replace them in a long-term historical perspective. These investigations were the product of a long-standing interest for individual differences in vulnerabilities relative to coping with stressful situations and for potential pathological conditions such as drug abuse. The rationale was, and still is, to decipher the psychobiological characteristics of these complex traits. STRESS- AND PHARMACOLOGICALLY-INDUCED BEHAVIORAL SENSITIZATION INCREASES VULNERABILITY TO ACQUISITION OF AMPHETAMINE SELF-ADMINISTRATION: Individual vulnerability to drug addiction may be an important factor in the prognosis of pathological behavior in man. However, experimental investigations have largely neglected the psychobiological substrate of predisposition to addiction. In this study, we use a self-administration (SA) acquisition paradigm showing that previous repeated exposure to a stressful experience (tail-pinch) or to amphetamine increases the locomotor response to this drug (behavioral sensitization) and enhances vulnerability to amphetamine SA. These results show that vulnerability to developing amphetamine SA may be influenced by stressful experiences, and that previous contact with the drug may also enhance a predisposition to amphetamine-taking behavior. As tail-pinch and amphetamine sensitization affect both the dopamine (DA) neural system and the propensity to self-administer amphetamine (a behavior also modulated by DA activity), stress may influence SA via an action on the DA system. © 1990. This article is part of a Special Issue entitled SI:50th Anniversary Issue. Copyright © 2016 Elsevier B.V. All rights reserved.

Social Determinants of Health, Disaster Vulnerability, Severe and Morbid Obesity in Adults: Triple Jeopardy?

PubMed Central

2017-01-01

Severe and morbid obesity are associated with highly elevated risks of adverse health outcomes and the prevalence of severe obesity is increasing globally. To date, disaster literature has not considered severe and morbid obesity as a specific vulnerability, despite reports of people being left behind during disasters because of their body size, shape or weight. The complex causes of obesity are associated with the social determinants of health and one’s potential vulnerability to disasters. The absence of appropriate considerations may lead to people being exposed to disproportionate and potentially avoidable risk. The intersection of the social determinants of health, disaster vulnerability, severe and morbid obesity is explored. Previously identified vulnerable groups are also represented in severe and morbid obesity data. This poses the prospect for ‘triple jeopardy’ compounding the social determinants of health, disaster vulnerability and considerations with and for people with morbid obesity. When working to reduce disaster risk for vulnerable groups, the author proposes specific consideration is required to ensure ‘all-of-society engagement and partnership’ in an inclusive, accessible and non-discriminatory manner, to ensure no one is left behind.

Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug

PubMed Central

Natividad, Luis A.; Torres, Oscar V.; Friedman, Theodore C.; O'Dell, Laura E.

2014-01-01

This study compared nicotine intake and changes in food intake and weight gain in naïve adolescent, naïve adult, and adult rats that were exposed to nicotine during adolescence. An extended intravenous self-administration (IVSA) model was used whereby rats had 23-hour access to saline or increasing doses of nicotine (0.03, 0.06, and 0.09 mg/kg/0.1 mL infusion) for 4-day intervals separated by 3-day periods of abstinence. Rats began IVSA as adolescents (PND 32–34) or adults (PND 75). A separate group of rats was exposed to nicotine via osmotic pumps (4.7 mg/kg) for 14 days during adolescence and then began nicotine IVSA as adults (PND 75). The rats that completed the nicotine IVSA regimen were also tested for nicotine-seeking behavior during extinction. The results revealed that nicotine intake was highest in adolescents followed by adults that were pre-exposed to nicotine during adolescence as compared to naïve adults. A similar pattern of nicotine-seeking behavior was observed during extinction. In contrast to nicotine intake, naïve adults displayed robust appetite and weight suppressant effects of nicotine, an effect that was absent in adolescents and adults that were pre-exposed to nicotine during adolescence. Our findings suggest that adolescence is a unique period of enhanced vulnerability to the reinforcing effects of nicotine. Although adolescents gain weight faster than adults, the food intake and weight suppressant effects of nicotine are reduced during adolescence. Importantly, our findings suggest that adolescent nicotine exposure produces long-lasting consequences that enhance nicotine reward and promote tolerance to the anorectic effects of this drug. PMID:24120402

HIV+ and HIV- youth living in group homes in South Africa need more psychosocial support.

PubMed

Nestadt, D F; Alicea, S; Petersen, I; John, S; Myeza, N P; Nicholas, S W; Cohen, L G; Holst, H; Bhana, A; McKay, M M; Abrams, E J; Mellins, C A

2013-07-01

Orphans and vulnerable youth who live in group homes are at risk of poor mental health and sexual and drug-using behaviors that increase the risk of HIV transmission. This study explores factors related to this risk among youth living in group homes ("children's homes") for orphans and vulnerable children in South Africa, a country afflicted by high levels of parental loss due to HIV. The study explores 1) knowledge and attitudes about HIV, 2) social support, 3) communication with group home caregivers, and 4) the relevance of an existing evidence-based HIV prevention and mental health promotion program to situations where sexual and drug risk behaviors can occur. In-depth qualitative individual interviews were conducted with 20 youth (age 10 to 16 years) residing in two children's homes in Durban, South Africa. Content analysis focused on critical themes related to coping and prevention of risk activities. Respondents exhibited inconsistent and incomplete knowledge of HIV transmission and prevention. They displayed positive attitudes toward people living with HIV, but reported experiencing or witnessing HIV-related stigma. Participants witnessed substance use and romantic/sexual relationships among their peers; few admitted to their own involvement. While relationships with childcare workers were central to their lives, youth reported communication barriers related to substance use, sex, HIV, and personal history (including parental loss, abuse, and other trauma). In conclusion, these qualitative data suggest that evidence-based HIV prevention programs that bring caregivers and youth together to improve communication, HIV knowledge, social support, youth self-esteem, and health care, reduce sexual and drug risk behaviors, and strengthen skills related to negotiating situations of sexual and substance use possibility could benefit youth and childcare workers in children's homes.

Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: A comparison of male-to-female, female-to-male transsexual and nontranssexual control subjects.

PubMed

Simon, Lajos; Zsolt, Unoka; Fogd, Dora; Czobor, Pál

2011-03-01

Research into the association between Gender Identity Disorder (GID) and psychological disturbances as well as on its relation with parenting experiences yielded mixed results, with different patterns for Male-to-Female (MF) and Female-to-Male (FM) transsexual subjects. We investigated vulnerability markers of maladjustment and their possible origins in MF and FM transsexuals by examining maladaptive core beliefs and parenting behaviors thought to be specifically related to them. Dysfunctional core beliefs, parenting experiences and psychiatric symptoms were assessed by the Young Schema Questionnaire indexing 19 Early Maladaptive Schemas (EMS), the Young Parenting Inventory and the Symptom Checklist-90-R, respectively, in 30 MF, 17 FM transsexual and 114 control subjects (43 males, 114 females). Subjects with GID demonstrated a level of psychiatric distress comparable to that of controls. They did display elevated scores, however, on multiple EMSs compared to nontranssexual subjects, indicating feelings of isolation, emotional deprivation and an urge to meet others' needs, with MF transsexuals conceptualizing themselves also as more vulnerable and deficient than controls. Parenting experiences of transsexual subjects were characterised by increased maternal dominance, emotional abuse and neglect compared to controls, with males being exposed to a disengaged maternal style and more paternal emotional neglect and criticism. Both MF and FM transsexuals were made felt that in areas of achievement they will inevitably fail. There is no evidence of elevated levels of psychiatric symptoms in GID, but potential predisposing factors, particularly in MF transsexuals, are present; these may originate from the more intense rejection they experience. Copyright © 2010 Elsevier Ltd. All rights reserved.

Cognitive processes and attitudes in bipolar disorder: a study into personality, dysfunctional attitudes and attention bias in patients with bipolar disorder and their relatives.

PubMed

Jabben, Nienke; Arts, Baer; Jongen, Ellen M M; Smulders, Fren T Y; van Os, Jim; Krabbendam, Lydia

2012-12-20

Research in cognitive processes and attitudes in bipolar disorder is scarce and has provided mixed findings, possibly due to differences in current mood state. It is unclear whether alterations in cognitive processes and attitudes are only related to the depressive mood states of bipolar patients or also represent a vulnerability marker for the development of future (depressive) episodes. This was investigated in the current study. Both implicit (attentional bias for emotional words) and explicit (dysfunctional attitudes and personality characteristics) measures of cognitive processes and attitudes were assessed in 77 bipolar patients with varying levels of depressive symptoms (depressed=17, euthymic n=60), their healthy first-degree relatives (n=39) and a healthy control group (n=61). Analyses of variance were used to investigate differences between groups. Mildly depressed patients with bipolar disorder demonstrated an attentional bias away from positive emotional words and showed increased dysfunctional attitudes and higher levels of neuroticism. Euthymic patients were largely comparable to healthy controls and only differed from controls in higher levels of neuroticism. Relatives were similar to controls on all measures, although they significantly differed from bipolar patients in displaying less neuroticism and more extraversion. No firm conclusions regarding causality can be drawn from the associations that were found between cognitive processes and attitudes and the evolution of mood symptoms in bipolar disorder. Alterations in cognitive processes and attitudes in bipolar patients appear to be mostly related to the expression of mood symptomatology rather than to the vulnerability for bipolar disorder. Copyright © 2012 Elsevier B.V. All rights reserved.

HIV+ and HIV− youth living in group homes in South Africa need more psychosocial support

PubMed Central

Nestadt, D.F.; Alicea, S.; Petersen, I.; John, S.; Myeza, N.P.; Nicholas, S.W.; Cohen, L.G.; Holst, H.; Bhana, A.; McKay, M.M.; Abrams, E.J.; Mellins, C.A.

2013-01-01

Orphans and vulnerable youth who live in group homes are at risk of poor mental health and sexual and drug-using behaviors that increase the risk of HIV transmission. This study explores factors related to this risk among youth living in group homes (“children’s homes”) for orphans and vulnerable children in South Africa, a country afflicted by high levels of parental loss due to HIV. The study explores 1) knowledge and attitudes about HIV, 2) social support, 3) communication with group home caregivers, and 4) the relevance of an existing evidence-based HIV prevention and mental health promotion program to situations where sexual and drug risk behaviors can occur. In-depth qualitative individual interviews were conducted with 20 youth (age 10 to 16 years) residing in two children’s homes in Durban, South Africa. Content analysis focused on critical themes related to coping and prevention of risk activities. Respondents exhibited inconsistent and incomplete knowledge of HIV transmission and prevention. They displayed positive attitudes toward people living with HIV, but reported experiencing or witnessing HIV-related stigma. Participants witnessed substance use and romantic/sexual relationships among their peers; few admitted to their own involvement. While relationships with childcare workers were central to their lives, youth reported communication barriers related to substance use, sex, HIV, and personal history (including parental loss, abuse, and other trauma). In conclusion, these qualitative data suggest that evidence-based HIV prevention programs that bring caregivers and youth together to improve communication, HIV knowledge, social support, youth self-esteem, and health care, reduce sexual and drug risk behaviors, and strengthen skills related to negotiating situations of sexual and substance use possibility could benefit youth and childcare workers in children’s homes. PMID:24039626

Acute treatment with cannabinoid receptor agonist WIN55212.2 improves prepulse inhibition in psychosocially stressed mice.

PubMed

Brzózka, Magdalena M; Fischer, André; Falkai, Peter; Havemann-Reinecke, Ursula

2011-04-15

Cannabis, similar to psychosocial stress, is well known to exacerbate psychotic experiences and can precipitate psychotic episodes in vulnerable individuals. Cannabinoid receptors 1 (CB1) are widely expressed in the brain and are particularly important to mediate the effects of cannabis. Chronic cannabis use in patients and chronic cannabinoids treatment in animals is known to cause reduced prepulse inhibition (PPI). Similarly, chronic psychosocial stress in mice impairs PPI. In the present study, we investigated the synergistic effects of substances modulating the CB1-receptors and chronic psychosocial stress on PPI. For this purpose, adult C57Bl/6J mice were exposed to chronic psychosocial stress using the resident-intruder paradigm. The cannabinoid receptor agonist WIN55212.2 served as a surrogate marker for the effects of cannabis in the brain. After exposure to stress mice were acutely injected with WIN55212.2 (3 mg/kg) with or without pre-treatment with Rimonabant (3 mg/kg), a specific CB1-receptor antagonist, and subjected to behavioral testing. Stressed mice displayed a higher vulnerability to WIN55212.2 in the PPI test than control animals. The effects of WIN55212.2 on PPI were antagonized by Rimonabant suggesting an involvement of CB1-receptors in sensorimotor gating. Interestingly, WIN55212.2 increased PPI in psychosocially stressed mice although previous studies in rats showed the opposite effects. It may thus be possible, that depending on the doses of cannabinoids/CB1-receptor agonists applied and environmental conditions (psychosocial stress), opposite effects can be evoked in different experimental animals. Taken together, our data imply that CB1-receptors might play a crucial role in the synergistic effects of psychosocial stress and cannabinoids in brain. Copyright © 2010 Elsevier B.V. All rights reserved.

Overexpression of human mutated G93A SOD1 changes dynamics of the ER mitochondria calcium cycle specifically in mouse embryonic motor neurons.

PubMed

Lautenschläger, Janin; Prell, Tino; Ruhmer, Julia; Weidemann, Lisa; Witte, Otto W; Grosskreutz, Julian

2013-09-01

Motor neurons vulnerable to the rapidly progressive deadly neurodegenerative disease amyotrophic lateral sclerosis (ALS) inherently express low amounts of calcium binding proteins (CaBP), likely to allow physiological motor neuron firing frequency modulation. At the same time motor neurons are susceptible to AMPA receptor mediated excitotoxicity and internal calcium deregulation which is not fully understood. We analysed ER mitochondria calcium cycle (ERMCC) dynamics with subsecond resolution in G93A hSOD1 overexpressing motor neurons as a model of ALS using fluorescent calcium imaging. When comparing vulnerable motor neurons and non-motor neurons from G93A hSOD1 mice and their non-transgenic littermates, we found a decelerated cytosolic calcium clearance in the presence of G93A hSOD1. While both non-transgenic as well as G93A hSOD1 motor neurons displayed large mitochondrial calcium uptake by the mitochondrial uniporter (mUP), the mitochondrial calcium extrusion system was altered in the presence of G93A hSOD1. In addition, ER calcium uptake by the sarco-/endoplasmic reticulum ATPase (SERCA) was increased in G93A hSOD1 motor neurons. In survival assays, blocking the mitochondrial sodium calcium exchanger (mNCE) by CGP37157 as well as inhibiting SERCA by cyclopiazonic acid showed protective effects against kainate induced excitotoxicity. Thus, our study shows for the first time that the functional consequence of G93A hSOD1 overexpression in intact motor neurons is indeed a disturbance of the ER mitochondria calcium cycle, and identified two promising targets for therapeutic intervention in the pathology of ALS. Copyright © 2013 Elsevier Inc. All rights reserved.

Downstream Warming and Headwater Acidity May Diminish Coldwater Habitat in Southern Appalachian Mountain Streams.

PubMed

McDonnell, T C; Sloat, M R; Sullivan, T J; Dolloff, C A; Hessburg, P F; Povak, N A; Jackson, W A; Sams, C

2015-01-01

Stream-dwelling species in the U.S. southern Appalachian Mountains region are particularly vulnerable to climate change and acidification. The objectives of this study were to quantify the spatial extent of contemporary suitable habitat for acid- and thermally sensitive aquatic species and to forecast future habitat loss resulting from expected temperature increases on national forest lands in the southern Appalachian Mountain region. The goal of this study was to help watershed managers identify and assess stream reaches that are potentially vulnerable to warming, acidification, or both. To our knowledge, these results represent the first regional assessment of aquatic habitat suitability with respect to the combined effects of stream water temperature and acid-base status in the United States. Statistical models were developed to predict July mean daily maximum water temperatures and air-water temperature relations to determine potential changes in future stream water temperatures. The length of stream considered suitable habitat for acid- and thermally sensitive species, based on temperature and acid neutralizing capacity thresholds of 20°C and 50 μeq/L, was variable throughout the national forests considered. Stream length displaying temperature above 20°C was generally more than five times greater than the length predicted to have acid neutralizing capacity below 50 μeq/L. It was uncommon for these two stressors to occur within the same stream segment. Results suggested that species' distributional shifts to colder, higher elevation habitats under a warming climate can be constrained by acidification of headwater streams. The approach used in this study can be applied to evaluate climate change impacts to stream water resources in other regions.

Downstream Warming and Headwater Acidity May Diminish Coldwater Habitat in Southern Appalachian Mountain Streams

PubMed Central

Jackson, W. A; Sams, C.

2015-01-01

Stream-dwelling species in the U.S. southern Appalachian Mountains region are particularly vulnerable to climate change and acidification. The objectives of this study were to quantify the spatial extent of contemporary suitable habitat for acid- and thermally sensitive aquatic species and to forecast future habitat loss resulting from expected temperature increases on national forest lands in the southern Appalachian Mountain region. The goal of this study was to help watershed managers identify and assess stream reaches that are potentially vulnerable to warming, acidification, or both. To our knowledge, these results represent the first regional assessment of aquatic habitat suitability with respect to the combined effects of stream water temperature and acid-base status in the United States. Statistical models were developed to predict July mean daily maximum water temperatures and air-water temperature relations to determine potential changes in future stream water temperatures. The length of stream considered suitable habitat for acid- and thermally sensitive species, based on temperature and acid neutralizing capacity thresholds of 20°C and 50 μeq/L, was variable throughout the national forests considered. Stream length displaying temperature above 20°C was generally more than five times greater than the length predicted to have acid neutralizing capacity below 50 μeq/L. It was uncommon for these two stressors to occur within the same stream segment. Results suggested that species’ distributional shifts to colder, higher elevation habitats under a warming climate can be constrained by acidification of headwater streams. The approach used in this study can be applied to evaluate climate change impacts to stream water resources in other regions. PMID:26247361

Factors Contributing to Exacerbating Vulnerabilities in Global Clinical Trials

PubMed Central

da Silva, Ricardo E.; Amato, Angélica A.; Guilhem, Dirce B.; de Carvalho, Marta R.; Lima, Elisangela da C.; Novaes, Maria Rita C. G.

2018-01-01

Background: Although policies and guidelines make use of the concept of vulnerability, few define it. The European Union's directive for clinical trials does not include explanations for or the reasoning behind the designation of certain groups as vulnerable. Emerging economies from lower middle-income countries have, in recent years, had the largest average annual growth rate, as well as increase, in number of clinical trials registered in the US government's database. Nevertheless, careful supervision of research activities has to be ensured. Objective: To describe and analyze the features of the clinical trials involving vulnerable populations in various countries classified by development status and geographic region. Methods: Retrospective study that involved analysis of data obtained from the International Clinical Trials Registry Platform (ICTRP) database between 01/2014 and 12/2014 from countries with (i) highest trial densities during 2005 to 2012, (ii) highest average growth rate in clinical trials, and (iii) greatest trial capabilities. Results: Statistical analysis of this study showed that patients incapable of giving consent personally are 11.4 times more likely to be vulnerable patients than patients who are capable, and that patients in upper-middle-income countries are 1.7 times more likely to be vulnerable patients than patients from high-income countries when participating in global clinical trials. Malaysia (21%), Egypt (20%), Turkey (19%), Israel (18%), and Brazil (17%) had the highest percentages of vulnerable populations involving children. Conclusions: Although the inability to provide consent personally was a factor associated with vulnerability, arbitrary criteria may have been considered when classifying the populations of clinical trials as vulnerable. The EU Clinical Trials Register should provide guidance regarding exactly what aspects or factors should be taken into account to frame given populations as vulnerable, because vulnerability is not applicable to all risk situations. PMID:29403381

Factors Contributing to Exacerbating Vulnerabilities in Global Clinical Trials.

PubMed

da Silva, Ricardo E; Amato, Angélica A; Guilhem, Dirce B; de Carvalho, Marta R; Lima, Elisangela da C; Novaes, Maria Rita C G

2017-01-01

Background: Although policies and guidelines make use of the concept of vulnerability, few define it. The European Union's directive for clinical trials does not include explanations for or the reasoning behind the designation of certain groups as vulnerable. Emerging economies from lower middle-income countries have, in recent years, had the largest average annual growth rate, as well as increase, in number of clinical trials registered in the US government's database. Nevertheless, careful supervision of research activities has to be ensured. Objective: To describe and analyze the features of the clinical trials involving vulnerable populations in various countries classified by development status and geographic region. Methods: Retrospective study that involved analysis of data obtained from the International Clinical Trials Registry Platform (ICTRP) database between 01/2014 and 12/2014 from countries with (i) highest trial densities during 2005 to 2012, (ii) highest average growth rate in clinical trials, and (iii) greatest trial capabilities. Results: Statistical analysis of this study showed that patients incapable of giving consent personally are 11.4 times more likely to be vulnerable patients than patients who are capable, and that patients in upper-middle-income countries are 1.7 times more likely to be vulnerable patients than patients from high-income countries when participating in global clinical trials. Malaysia (21%), Egypt (20%), Turkey (19%), Israel (18%), and Brazil (17%) had the highest percentages of vulnerable populations involving children. Conclusions: Although the inability to provide consent personally was a factor associated with vulnerability, arbitrary criteria may have been considered when classifying the populations of clinical trials as vulnerable. The EU Clinical Trials Register should provide guidance regarding exactly what aspects or factors should be taken into account to frame given populations as vulnerable, because vulnerability is not applicable to all risk situations.

Twelve-year mortality in HIV-infected patients receiving antiretroviral therapy: the role of social vulnerability. The ANRS CO8 APROCO-COPILOTE cohort.

PubMed

Protopopescu, Camelia; Raffi, François; Spire, Bruno; Hardel, Lucile; Michelet, Christian; Cheneau, Christine; Le Moing, Vincent; Leport, Catherine; Carrieri, Maria Patrizia

2015-01-01

Although the role of clinical/biological factors associated with mortality has already been explored in HIV-infected patients on antiretroviral therapy (ART), to date little attention has been given to the potential role of social vulnerability. This study aimed to construct an appropriate measure of social vulnerability and to evaluate whether this measure is predictive of increased mortality risk in ART-treated patients followed up in the ANRS CO8 APROCO-COPILOTE cohort. The cohort enrolled 1,281 patients initiating a protease inhibitor-based regimen in 1997-1999. Clinical/laboratory data were collected every 4 months. Self-administered questionnaires collected psycho-social/behavioural characteristics at enrolment (month [M] 0), M4 and every 8-12 months thereafter. A multiple correspondence analysis using education, employment and housing indicators helped construct a composite indicator measuring social vulnerability. The outcome studied was all-cause deaths occurring after M4. The relationship between social vulnerability and mortality, after adjustment for other predictors, was studied using a shared-frailty Cox model, taking into account informative study dropout. Over a median (IQR) follow-up of 7.9 (3.0-11.2) years, 121 deaths occurred among 1,057 eligible patients, corresponding to a mortality rate (95% CI) of 1.64 (1.37, 1.96)/100 person-years. Leading causes of death were non-AIDS defining cancers (n=26), AIDS (n=23) and cardiovascular diseases (n=12). Social vulnerability (HR [95% CI] =1.2 [1.0, 1.5]) was associated with increased mortality risk, after adjustment for other known behavioural and bio-medical predictors. Social vulnerability remains a major mortality predictor in ART-treated patients. A real need exists for innovative interventions targeting individuals cumulating several sources of social vulnerability, to ensure that social inequalities do not continue to lead to higher mortality.

Extinction vulnerability of coral reef fishes.

PubMed

Graham, Nicholas A J; Chabanet, Pascale; Evans, Richard D; Jennings, Simon; Letourneur, Yves; Aaron Macneil, M; McClanahan, Tim R; Ohman, Marcus C; Polunin, Nicholas V C; Wilson, Shaun K

2011-04-01

With rapidly increasing rates of contemporary extinction, predicting extinction vulnerability and identifying how multiple stressors drive non-random species loss have become key challenges in ecology. These assessments are crucial for avoiding the loss of key functional groups that sustain ecosystem processes and services. We developed a novel predictive framework of species extinction vulnerability and applied it to coral reef fishes. Although relatively few coral reef fishes are at risk of global extinction from climate disturbances, a negative convex relationship between fish species locally vulnerable to climate change vs. fisheries exploitation indicates that the entire community is vulnerable on the many reefs where both stressors co-occur. Fishes involved in maintaining key ecosystem functions are more at risk from fishing than climate disturbances. This finding is encouraging as local and regional commitment to fisheries management action can maintain reef ecosystem functions pending progress towards the more complex global problem of stabilizing the climate. © 2011 Blackwell Publishing Ltd/CNRS.

Responses to Novelty and Vulnerability to Cocaine Addiction: Contribution of a Multi-Symptomatic Animal Model

PubMed Central

Belin, David; Deroche-Gamonet, Véronique

2012-01-01

Epidemiological studies have revealed striking associations between several distinct behavioral/personality traits and drug addiction, with a large emphasis on the sensation-seeking trait and the associated impulsive dimension of personality. However, in human studies, it is difficult to identify whether personality/behavioral traits actually contribute to increased vulnerability to drug addiction or reflect psychobiological adaptations to chronic drug exposure. Here we show how animal models, including the first multi-symptomatic model of addiction in the rat, have contributed to a better understanding of the relationships between different subdimensions of the sensation-seeking trait and different stages of the development of cocaine addiction, from vulnerability to initiation of cocaine self-administration to the transition to compulsive drug intake. We argue that sensation seeking predicts vulnerability to use cocaine, whereas novelty seeking, akin to high impulsivity, predicts instead vulnerability to shift from controlled to compulsive cocaine use, that is, addiction. PMID:23125204

A dynamic vulnerability evaluation model to smart grid for the emergency response

NASA Astrophysics Data System (ADS)

Yu, Zhen; Wu, Xiaowei; Fang, Diange

2018-01-01

Smart grid shows more significant vulnerability to natural disasters and external destroy. According to the influence characteristics of important facilities suffered from typical kinds of natural disaster and external destroy, this paper built a vulnerability evaluation index system of important facilities in smart grid based on eight typical natural disasters, including three levels of static and dynamic indicators, totally forty indicators. Then a smart grid vulnerability evaluation method was proposed based on the index system, including determining the value range of each index, classifying the evaluation grade standard and giving the evaluation process and integrated index calculation rules. Using the proposed evaluation model, it can identify the most vulnerable parts of smart grid, and then help adopting targeted emergency response measures, developing emergency plans and increasing its capacity of disaster prevention and mitigation, which guarantee its safe and stable operation.

Extinction vulnerability of coral reef fishes

PubMed Central

Graham, Nicholas A J; Chabanet, Pascale; Evans, Richard D; Jennings, Simon; Letourneur, Yves; Aaron MacNeil, M; McClanahan, Tim R; Öhman, Marcus C; Polunin, Nicholas V C; Wilson, Shaun K

2011-01-01

With rapidly increasing rates of contemporary extinction, predicting extinction vulnerability and identifying how multiple stressors drive non-random species loss have become key challenges in ecology. These assessments are crucial for avoiding the loss of key functional groups that sustain ecosystem processes and services. We developed a novel predictive framework of species extinction vulnerability and applied it to coral reef fishes. Although relatively few coral reef fishes are at risk of global extinction from climate disturbances, a negative convex relationship between fish species locally vulnerable to climate change vs. fisheries exploitation indicates that the entire community is vulnerable on the many reefs where both stressors co-occur. Fishes involved in maintaining key ecosystem functions are more at risk from fishing than climate disturbances. This finding is encouraging as local and regional commitment to fisheries management action can maintain reef ecosystem functions pending progress towards the more complex global problem of stabilizing the climate. PMID:21320260

Relating Climate and Enviornmental Stress to Conflict... or Cooperation?

NASA Astrophysics Data System (ADS)

Kelley, C. P.

2016-12-01

There are many factors which contribute to social unrest, including governance, economy, access to resources and others. As global climate change progresses, many regions and nations, particularly those that are most vulnerable and least resilient, will face increasing challenges with respect to water and food scarcity. Increasing population and demand for water, combined with declining access to groundwater, will greatly increase exisiting vulnerability. Syria, Yemen and other countries serve as examples of nations that have experienced increasing both environmental stress and conflict. The Syria case in particular has had clear global repercussions, most notably contributing to a global refugee crisis. However, there are also examples of nations that have experienced increasing environmental stress that instead demonstrated transboundary water cooperation rather than conflict. An important and emerging body of work is that which seeks to better understand and characterize real-time resilience and vulnerability in order to better mitigate the consequences of future regional climate change. Prediction of potential conflict is a formidable challenge, one that is highly complex and multivariate, operating on many different temporal and spatial scales.

BEACH GRASS INVASIONS AND COASTAL FLOOD PROTECTION: FORECASTING THE EFFECTS OF CLIMATE CHANGE ON COASTAL VULNERABILITY

EPA Science Inventory

Our work will yield an increased general understanding of interactions among the alteration of coastal ecosystem, species invasions, climate change, and human risk in coastal environments. In addition, we will conduct a quantitative vulnerability assessment of a specific coast...

Predicting patterns of vulnerability to climate change in near coastal species using an algorithm-based risk assessment framework

EPA Science Inventory

Near-coastal (0-200 depth) ecosystems and species are under threat from increasing temperatures, ocean acidification, and sea level rise. However, species vary in their vulnerability to specific climatic changes and climate impacts will vary geographically. For management to resp...

Heavy Metal Music and Adolescent Suicidality: An Empirical Investigation.

ERIC Educational Resources Information Center

Scheel, Karen R.; Westefeld, John S.

1999-01-01

Investigates the relationship between preference for heavy metal music and vulnerability to suicide among high school students. Results indicate that preference for heavy metal music among adolescents may be sign of increased suicidal vulnerability, but also suggests that the source of the problem may lie more in personal and familial…

Political and Educational Springboard or Straitjacket? Theorising Post/Human Subjects in an Age of Vulnerability

ERIC Educational Resources Information Center

Ecclestone, Kathryn; Goodley, Daniel

2016-01-01

Contemporary discourses of social justice in education, disability, mental health, social policy and feminist studies are refracted increasingly through concerns about psychological and structural vulnerabilities created by the crises of late capitalism. Focusing on developments in British social policy generally and educational research…

Forecasting Urban Forest Ecosystem Structure, Function, and Vulnerability

Treesearch

James W. N. Steenberg; Andrew A. Millward; David J. Nowak; Pamela J. Robinson; Alexis Ellis

2016-01-01

The benefits derived from urban forest ecosystems are garnering increasing attention in ecological research and municipal planning. However, because of their location in heterogeneous and highly-altered urban landscapes, urban forests are vulnerable and commonly suffer disproportionate and varying levels of stress and disturbance. The objective of this study is to...

Social vulnerability assessment using spatial multi-criteria analysis (SEVI model) and the Social Vulnerability Index (SoVI model) - a case study for Bucharest, Romania

NASA Astrophysics Data System (ADS)

Armaş, I.; Gavriş, A.

2013-06-01

In recent decades, the development of vulnerability frameworks has enlarged the research in the natural hazards field. Despite progress in developing the vulnerability studies, there is more to investigate regarding the quantitative approach and clarification of the conceptual explanation of the social component. At the same time, some disaster-prone areas register limited attention. Among these, Romania's capital city, Bucharest, is the most earthquake-prone capital in Europe and the tenth in the world. The location is used to assess two multi-criteria methods for aggregating complex indicators: the social vulnerability index (SoVI model) and the spatial multi-criteria social vulnerability index (SEVI model). Using the data of the 2002 census we reduce the indicators through a factor analytical approach to create the indices and examine if they bear any resemblance to the known vulnerability of Bucharest city through an exploratory spatial data analysis (ESDA). This is a critical issue that may provide better understanding of the social vulnerability in the city and appropriate information for authorities and stakeholders to consider in their decision making. The study emphasizes that social vulnerability is an urban process that increased in a post-communist Bucharest, raising the concern that the population at risk lacks the capacity to cope with disasters. The assessment of the indices indicates a significant and similar clustering pattern of the census administrative units, with an overlap between the clustering areas affected by high social vulnerability. Our proposed SEVI model suggests adjustment sensitivity, useful in the expert-opinion accuracy.

Identification of vulnerability within a child and family health service.

PubMed

Kimla, Katarina; Nathanson, Dania; Woolfenden, Susan; Zwi, Karen

2017-11-21

Objective The aims of the present study were to describe the prevalence of vulnerability in a cohort of newborns, identify the factors that increase the risk of vulnerability and examine whether those who are most vulnerable are receiving home visits. Methods A prospective cross-sectional study was performed using data collected from questionnaires completed by child and family health nurses and obstetric discharge summaries for each mother-baby dyad. Descriptive frequencies and percentages are used to describe the proportions of children who were vulnerable, offered services and had risk factors for vulnerability. Categorical data were compared using Pearson's Chi-squared analysis. Results In all, 1517 newborns were included in the present study. Of these, 40.5% were identified as vulnerable and 13.9% had two or more risk factors for vulnerability (95% confidence interval (CI) 12-16%). The most common risk factors were biological. Across all newborns, 33.7% were visited at home, and 74.6% of vulnerable newborns were offered a home visit. Children identified as vulnerable were more likely to have a home visit than those who were not (z for 95% CI=1.96; P<0.1). Conclusions Although the high reported prevalence of identified risk needs to be confirmed in further studies, identifying vulnerability allowed the offer of home visiting to be directed towards those most likely to benefit. What is known about the topic? Of the Australian child population, 10-20% are vulnerable to adverse health, developmental and wellbeing outcomes. Vulnerable infants are at a greater risk of becoming vulnerable children, adolescents and adults over the life course. Biological and psychosocial risk factors for vulnerability are well described. Families with the greatest need are often the least likely to access or receive support, and have lower utilisation of preventative health services despite evidence that support in the first few years of life can significantly improve long-term outcomes. What does this paper add? This paper provides a detailed description of vulnerabilities in a cohort of newborns and demonstrates that it is possible to assign risk of vulnerability within existing child and family health services using tools that identify biological and psychosocial risk factors. Identification of vulnerability risk allows prioritisation of services to those with the greatest need. What are the implications for practitioners? It is possible to identify vulnerability risk within child and family health services. This allows those families at risk of future adverse health, developmental and wellbeing outcomes to be prioritised to receive health services and supports.

Effects of examination stress on psychological responses, sleep and allergic symptoms in atopic and non-atopic students.

PubMed

Jernelöv, Susanna; Höglund, Caroline Olgart; Axelsson, John; Axén, Jennie; Grönneberg, Reidar; Grunewald, Johan; Stierna, Pontus; Lekander, Mats

2009-01-01

Recent findings indicate that atopics may be more vulnerable to stress than non-atopics. However, the roles of psychological well-being and sleep in this presumed increased sensitivity are not known. To investigate the effects of a brief naturalistic stressor on psychological responses, sleep, and allergic symptoms and to compare those responses between atopic and non-atopic individuals. We assessed atopic and non-atopic students during a period without and during a period with examinations. For both atopic and non-atopic students, tension, anxiety, and depression deteriorated in response to examination, as did sleep latency and sleep quality. Overall, atopics were more tense, had more anxiety, longer sleep latencies, and were less well rested than non-atopics. Non-atopic students rose from bed later during the examination period. In response to examination, atopic students reported increased frequency of stress behaviors (e.g., eating fast), while decreased stress behaviors were reported by non-atopic students. Allergic symptoms were not affected. Atopic students were worse off in aspects of psychological well-being and sleep, but displayed only partly stronger responses to a stressor compared to non-atopic students. In spite of a broad negative response to examination, allergic symptoms were not affected.

Neonicotinoids target distinct nicotinic acetylcholine receptors and neurons, leading to differential risks to bumblebees

PubMed Central

Moffat, Christopher; Buckland, Stephen T.; Samson, Andrew J.; McArthur, Robin; Chamosa Pino, Victor; Bollan, Karen A.; Huang, Jeffrey T.-J.; Connolly, Christopher N.

2016-01-01

There is growing concern over the risk to bee populations from neonicotinoid insecticides and the long-term consequences of reduced numbers of insect pollinators to essential ecosystem services and food security. Our knowledge of the risk of neonicotinoids to bees is based on studies of imidacloprid and thiamethoxam and these findings are extrapolated to clothianidin based on its higher potency at nicotinic acetylcholine receptors. This study addresses the specificity and consequences of all three neonicotinoids to determine their relative risk to bumblebees at field-relevant levels (2.5 ppb). We find compound-specific effects at all levels (individual cells, bees and whole colonies in semi-field conditions). Imidacloprid and clothianidin display distinct, overlapping, abilities to stimulate Kenyon cells, indicating the potential to differentially influence bumblebee behavior. Bee immobility was induced only by imidacloprid, and an increased vulnerability to clothianidin toxicity only occurred following chronic exposure to clothianidin or thiamethoxam. At the whole colony level, only thiamethoxam altered the sex ratio (more males present) and only clothianidin increased queen production. Finally, both imidacloprid and thiamethoxam caused deficits in colony strength, while no detrimental effects of clothianidin were observed. Given these findings, neonicotinoid risk needs to be considered independently for each compound and target species. PMID:27124107

Neonicotinoids target distinct nicotinic acetylcholine receptors and neurons, leading to differential risks to bumblebees

NASA Astrophysics Data System (ADS)

Moffat, Christopher; Buckland, Stephen T.; Samson, Andrew J.; McArthur, Robin; Chamosa Pino, Victor; Bollan, Karen A.; Huang, Jeffrey T.-J.; Connolly, Christopher N.

2016-04-01

There is growing concern over the risk to bee populations from neonicotinoid insecticides and the long-term consequences of reduced numbers of insect pollinators to essential ecosystem services and food security. Our knowledge of the risk of neonicotinoids to bees is based on studies of imidacloprid and thiamethoxam and these findings are extrapolated to clothianidin based on its higher potency at nicotinic acetylcholine receptors. This study addresses the specificity and consequences of all three neonicotinoids to determine their relative risk to bumblebees at field-relevant levels (2.5 ppb). We find compound-specific effects at all levels (individual cells, bees and whole colonies in semi-field conditions). Imidacloprid and clothianidin display distinct, overlapping, abilities to stimulate Kenyon cells, indicating the potential to differentially influence bumblebee behavior. Bee immobility was induced only by imidacloprid, and an increased vulnerability to clothianidin toxicity only occurred following chronic exposure to clothianidin or thiamethoxam. At the whole colony level, only thiamethoxam altered the sex ratio (more males present) and only clothianidin increased queen production. Finally, both imidacloprid and thiamethoxam caused deficits in colony strength, while no detrimental effects of clothianidin were observed. Given these findings, neonicotinoid risk needs to be considered independently for each compound and target species.

miR-126 contributes to Parkinson disease by dysregulating IGF-1/PI3K signaling

PubMed Central

Kim, Woori; Lee, Yenarae; McKenna, Noah D.; Yi, Ming; Simunovic, Filip; Wang, Yulei; Kong, Benjamin; Rooney, Robert J.; Seo, Hyemyung; Stephens, Robert; Sonntag, Kai C.

2014-01-01

Dopamine (DA) neurons in sporadic Parkinson disease (PD) display dysregulated gene expression networks and signaling pathways that are implicated in PD pathogenesis. Micro (mi)RNAs are regulators of gene expression, which could be involved in neurodegenerative diseases. We determined the miRNA profiles in laser microdissected DA neurons from postmortem sporadic PD patients’ brains and age-matched controls. DA neurons had a distinctive miRNA signature and a set of miRNAs was dysregulated in PD. Bioinformatics analysis provided evidence for correlations of miRNAs with signaling pathways relevant to PD, including an association of miR-126 with insulin/IGF-1/PI3K signaling. In DA neuronal cell systems, enhanced expression of miR-126 impaired IGF-1 signaling and increased vulnerability to the neurotoxin 6-OHDA by downregulating factors in IGF-1/PI3K signaling, including its targets p85β, IRS-1, and SPRED1. Blocking of miR-126 function increased IGF-1 trophism and neuroprotection to 6-OHDA. Our data imply that elevated levels of miR-126 may play a functional role in DA neurons and in PD pathogenesis by downregulating IGF-1/PI3K/AKT signaling and that its inhibition could be a mechanism of neuroprotection. PMID:24559646

Melatonin Ameliorates Injury and Specific Responses of Ischemic Striatal Neurons in Rats

PubMed Central

Ma, Yuxin; Feng, Qiqi; Ma, Jing; Feng, Zhibo; Zhan, Mali; OuYang, Lisi; Mu, Shuhua; Liu, Bingbing; Jiang, Zhuyi; Jia, Yu; Li, Youlan

2013-01-01

Studies have confirmed that middle cerebral artery occlusion (MCAO) causes striatal injury in which oxidative stress is involved in the pathological mechanism. Increasing evidence suggests that melatonin may have a neuroprotective effect on cerebral ischemic damage. This study aimed to examine the morphological changes of different striatal neuron types and the effect of melatonin on striatal injury by MCAO. The results showed that MCAO induced striatum-related dysfunctions of locomotion, coordination, and cognition, which were remarkably relieved with melatonin treatment. MCAO induced severe striatal neuronal apoptosis and loss, which was significantly decreased with melatonin treatment. Within the outer zone of the infarct, the number of Darpp-32+ projection neurons and the densities of dopamine-receptor-1 (D1)+ and dopamine-receptor-2 (D2)+ fibers were reduced; however, both parvalbumin (Parv)+ and choline acetyltransferase (ChAT)+ interneurons were not significantly decreased in number, and neuropeptide Y (NPY)+ and calretinin (Cr)+ interneurons were even increased. With melatonin treatment, the loss of projection neurons and characteristic responses of interneurons were notably attenuated. The present study demonstrates that the projection neurons are rather vulnerable to ischemic damage, whereas the interneurons display resistance and even hyperplasia against injury. In addition, melatonin alleviates striatal dysfunction, neuronal loss, and morphological transformation of interneurons resulting from cerebral ischemia. PMID:23686363

Community Vulnerability to Health Impacts of Wildland Fire Smoke Exposure.

PubMed

Rappold, Ana G; Reyes, Jeanette; Pouliot, George; Cascio, Wayne E; Diaz-Sanchez, David

2017-06-20

Identifying communities vulnerable to adverse health effects from exposure to wildfire smoke may help prepare responses, increase the resilience to smoke and improve public health outcomes during smoke days. We developed a Community Health-Vulnerability Index (CHVI) based on factors known to increase the risks of health effects from air pollution and wildfire smoke exposures. These factors included county prevalence rates for asthma in children and adults, chronic obstructive pulmonary disease, hypertension, diabetes, obesity, percent of population 65 years of age and older, and indicators of socioeconomic status including poverty, education, income and unemployment. Using air quality simulated for the period between 2008 and 2012 over the continental U.S. we also characterized the population size at risk with respect to the level and duration of exposure to fire-originated fine particulate matter (fire-PM 2.5 ) and CHVI. We estimate that 10% of the population (30.5 million) lived in the areas where the contribution of fire-PM 2.5 to annual average ambient PM 2.5 was high (>1.5 μg/m 3 ) and that 10.3 million individuals experienced unhealthy air quality levels for more than 10 days due to smoke. Using CHVI we identified the most vulnerable counties and determined that these communities experience more smoke exposures in comparison to less vulnerable communities.

Vulnerability studies and integrated assessments for hazard risk reduction in Pittsburgh, PA (Invited)

NASA Astrophysics Data System (ADS)

Klima, K.

2013-12-01

Today's environmental problems stretch beyond the bounds of most academic disciplines, and thus solutions require an interdisciplinary approach. For instance, the scientific consensus is changes in the frequency and severity of many types of extreme weather events are increasing (IPCC 2012). Yet despite our efforts to reduce greenhouse gases, we continue to experience severe weather events such as Superstorm Sandy, record heat and blizzards, and droughts. These natural hazards, combined with increased vulnerability and exposure, result in longer-lasting disruptions to critical infrastructure and business continuity throughout the world. In order to protect both our lives and the economy, we must think beyond the bounds of any one discipline to include an integrated assessment of relevant work. In the wake of recent events, New York City, Washington, DC, Chicago, and a myriad of other cities have turned to their academic powerhouses for assistance in better understanding their vulnerabilities. This talk will share a case study of the state of integrated assessments and vulnerability studies of energy, transportation, water, real estate, and other main sectors in Pittsburgh, PA. Then the talk will use integrated assessment models and other vulnerability studies to create coordinated sets of climate projections for use by the many public agencies and private-sector organizations in the region.

Prefrontal vulnerabilities and whole brain connectivity in aging and depression.

PubMed

Lamar, Melissa; Charlton, Rebecca A; Ajilore, Olusola; Zhang, Aifeng; Yang, Shaolin; Barrick, Thomas R; Rhodes, Emma; Kumar, Anand

2013-07-01

Studies exploring the underpinnings of age-related neurodegeneration suggest fronto-limbic alterations that are increasingly vulnerable in the presence of disease including late life depression. Less work has assessed the impact of this specific vulnerability on widespread brain circuitry. Seventy-nine older adults (healthy controls=45; late life depression=34) completed translational tasks shown in non-human primates to rely on fronto-limbic networks involving dorsolateral (Self-Ordered Pointing Task) or orbitofrontal (Object Alternation Task) cortices. A sub-sample of participants also completed diffusion tensor imaging for white matter tract quantification (uncinate and cingulum bundle; n=58) and whole brain tract-based spatial statistics (n=62). Despite task associations to specific white matter tracts across both groups, only healthy controls demonstrated significant correlations between widespread tract integrity and cognition. Thus, increasing Object Alternation Task errors were associated with decreasing fractional anisotropy in the uncinate in late life depression; however, only in healthy controls was the uncinate incorporated into a larger network of white matter vulnerability associating fractional anisotropy with Object Alternation Task errors using whole brain tract-based spatial statistics. It appears that the whole brain impact of specific fronto-limbic vulnerabilities in aging may be eclipsed in the presence of disease-specific neuropathology like that seen in late life depression. Copyright © 2013 Elsevier Ltd. All rights reserved.

Mexico's epidemic of violence and its public health significance on average length of life

PubMed Central

Canudas-Romo, Vladimir; Aburto, José Manuel; García-Guerrero, Victor Manuel; Beltrán-Sánchez, Hiram

2017-01-01

Objectives A disproportionate number of homicides have caused Mexican life expectancy to stagnate during the new millennium. No efforts currently exist to quantify the harm of violent acts on the lives of the general population. We quantified the impact of perceived vulnerability on life expectancy. Methods Three Mexican national surveys on perceptions of public safety, life tables, and crime and vital statistics (2000–2014) were used. Prevalence rates of vulnerability/safety by age and sex were obtained from surveys at 2 different levels: federal state and home. The Sullivan method was used to estimate life expectancy lived with and without vulnerability for Mexican women and men. Results Overall life expectancy at age 20 stagnated between 2005 and 2014 for females and males; yet, there was an increase of 40% and 70% in average number of years lived with vulnerability at the state and home levels, respectively. In 2014, female life expectancy at age 20 was 59.5 years (95% CI 59.0 to 60.1); 71% of these years (42.3 years, 41.6 to 43.0) were spent with perceived vulnerability of violence taking place in the state and 26% at the home (15.3 years, 15 to 15.8). For males, life expectancy at age 20 was 54.5 years (53.7 to 55.1); 64% of these years (34.6 years, 34.0 to 35.4) were lived with perceived vulnerability of violence at the state and 20% at the home (11.1 years, 10.8 to 11.5). Conclusions The number of years lived with perceived vulnerability among Mexicans has increased by 30.5 million person-years over the last 10 years. If perceived vulnerability remains at its 2014 level, the average Mexican adults would be expected to live a large fraction of his/her life with perceived vulnerability of violence. Acts of violence continue to rise in the country and they should be addressed as a major public health issue before they become endemic. PMID:27451436

Vulnerable discipline: experiences of male competitive bodybuilders.

PubMed

Bjørnestad, Jone; Kandal, Øyvind; Anderssen, Norman

2014-09-01

The aim was to understand experiences of male competitive bodybuilders from a non-pathologizing perspective. Six male Norwegian competitive bodybuilders were interviewed. The interviews were analysed using a meaning condensation procedure resulting in five themes: being proud of capacity for discipline, seeing a perfectionist attitude as a necessary evil, experiencing recognition within the bodybuilding community, being stigmatized outside the bodybuilding community and going on stage to display a capacity for willpower and discipline. We suggest that bodybuilders may be stigmatized for breaking social norms: by their distinctive appearance, by the way they handle suspected drug use and by challenging gender norms. © The Author(s) 2013.

Far from the Lonely Crowd: The Trenchant Techno-Cynicism of Mr. Robot.

PubMed

Volmar, Daniel

2017-12-01

Mr. Robot is a television drama with an unusually techno-cynical premise, tying cybersecurity to the contemporary malaise of social alienation and political disengagement. Weary of consumer capitalism, the show's youthful protagonists seek a more authentic sense of belonging by exploiting the vulnerability of a global economic system that depends critically on creaking technological infrastructures. A remarkable display of iconoclasm for commercial entertainment, Mr. Robot suggests rising discontentment with the commodification of friendship through consumer electronics, but it may also offer media enterprises a model for how to profit from that discontentment in the future. Copyright © 2017 Elsevier Ltd. All rights reserved.

Redox proteomic profiling of neuroketal-adducted proteins in human brain: Regional vulnerability at middle age increases in the elderly.

PubMed

Domínguez, Mayelín; de Oliveira, Eliandre; Odena, María Antonia; Portero, Manuel; Pamplona, Reinald; Ferrer, Isidro

2016-06-01

Protein lipoxidation was assessed in the parietal cortex (PC), frontal cortex (FC), and cingulate gyrus (CG) in middle-aged and old-aged individuals with no clinical manifestations of cognitive impairment, in order to increase understanding of regional brain vulnerability to oxidative damage during aging. Twenty-five lipoxidized proteins were identified in all the three regions although with regional specificities, by using redox proteomics to detect target proteins of neuroketals (NKT) adduction. The number of cases with NKT-adducted proteins was higher in old-aged individuals but most oxidized proteins were already present in middle-aged individuals. Differences in vulnerability to oxidation were dependent on the sub-cellular localization, secondary structure, and external exposition of certain amino acids. Lipoxidized proteins included those involved in energy metabolism, cytoskeleton, proteostasis, neurotransmission and O2/CO2, and heme metabolism. Total NKT and soluble oligomer levels were estimated employing slot-blot, and these were compared between age groups. Oligomers increased with age in PC and FC; NKT significantly increased with age in FC, whereas total NKT and oligomer levels were not modified in CG, thus highlighting differences in brain regional vulnerability with age. Oligomers significantly correlated with NKT levels in the three cortical regions, suggesting that protein NKT adduction parallels soluble oligomer formation. Copyright © 2016 Elsevier Inc. All rights reserved.

Urine Scent Marking (USM): A Novel Test for Depressive-Like Behavior and a Predictor of Stress Resiliency in Mice

PubMed Central

Lehmann, Michael L.; Geddes, Claire E.; Lee, Jennifer L.; Herkenham, Miles

2013-01-01

Decreased interest in pleasurable stimuli including social withdrawal and reduced libido are some of the key symptomatic criteria for major depression, and thus assays that measure social and sexual behavior in rodents may be highly appropriate for modeling depressive states. Here we present a novel approach for validating rodent models of depression by assessing male urine scent marking (USM) made in consequence to a spot of urine from a proestrous female. USM is an ethologically important form of sexual communication expressed by males to attract females. The expression of this behavior is highly sensitive and adaptive to environmental cues and social status. We hypothesized that male USM behavior offers a naturalistic measure of social motivation that can be used to evaluate hedonic behaviors relevant to the study of mood disorders. We demonstrated that 1) adult male mice displayed a strong preference for marking proestrous female urine with a high degree of specificity, 2) exposure to chronic social defeat profoundly decreased USM whereas exposure to environmental enrichment increased USM, 3) the standard antidepressant fluoxetine reversed declines in USM induced by social defeat, 4) USM behavior closely correlated with other hedonic measures, and 5) USM scores in non-stressed mice predicted behavioral outcomes after defeat exposure such that mice displaying high preference for marking female urine prior to social defeat showed behavioral resiliency after social defeat. The findings indicate that the USM test is a sensitive, validated measure of psychosocial stress effects that has high predictive value for examination of stress resiliency and vulnerability and their neurobiological substrates. PMID:23875001

Visual Detection of Speckles in the Fish Xenotoca variata by the Predatory Snake Thamnophis melanogaster in Water of Different Turbidity

PubMed Central

Manjarrez, Javier; Rivas-González, Eric; Venegas-Barrera, Crystian S.; Moyaho, Alejandro

2015-01-01

Semi-aquatic snakes integrate visual and chemical stimuli, and prey detection and capture success are therefore linked to the display of visual predatory behavior. The snake Thamnophis melanogaster responds preferentially to individuals of the fish Xenotoca variata with a greater number of bright, colorful spots (lateral speckles) compared with those with a smaller number; however, water turbidity can reduce underwater visibility and effect the vulnerability of fish. In this study, we tested whether the presence of iridescent speckles on the flanks of male X. variata interacted with water turbidity to modify the predatory behavior displayed by the snake T. melanogaster. We predicted that in an experimental laboratory test, the snakes would increase the frequency of their predatory behavior to the extent that the water turbidity decreases. The snakes were tested at six different levels of water turbidity, in combination with three categories of male fish (with few, a median number of, or many speckles). The results showed that in a pool with high or zero turbidity, the number of speckles is not a determining factor in the deployment of the predatory behavior of the snake T. melanogaster toward X. variata. Our findings suggest that snakes can view the fish at intermediate percentages of turbidity, but the number of speckles in male X. variata is irrelevant as an interspecific visual signal in environments with insufficient luminosity. The successful capture of aquatic prey is influenced by integration between chemical and visual signals, according to environmental factors that may influence the recognition of individual traits. PMID:26061294

Visual Detection of Speckles in the Fish Xenotoca variata by the Predatory Snake Thamnophis melanogaster in Water of Different Turbidity.

PubMed

Manjarrez, Javier; Rivas-González, Eric; Venegas-Barrera, Crystian S; Moyaho, Alejandro

2015-01-01

Semi-aquatic snakes integrate visual and chemical stimuli, and prey detection and capture success are therefore linked to the display of visual predatory behavior. The snake Thamnophis melanogaster responds preferentially to individuals of the fish Xenotoca variata with a greater number of bright, colorful spots (lateral speckles) compared with those with a smaller number; however, water turbidity can reduce underwater visibility and effect the vulnerability of fish. In this study, we tested whether the presence of iridescent speckles on the flanks of male X. variata interacted with water turbidity to modify the predatory behavior displayed by the snake T. melanogaster. We predicted that in an experimental laboratory test, the snakes would increase the frequency of their predatory behavior to the extent that the water turbidity decreases. The snakes were tested at six different levels of water turbidity, in combination with three categories of male fish (with few, a median number of, or many speckles). The results showed that in a pool with high or zero turbidity, the number of speckles is not a determining factor in the deployment of the predatory behavior of the snake T. melanogaster toward X. variata. Our findings suggest that snakes can view the fish at intermediate percentages of turbidity, but the number of speckles in male X. variata is irrelevant as an interspecific visual signal in environments with insufficient luminosity. The successful capture of aquatic prey is influenced by integration between chemical and visual signals, according to environmental factors that may influence the recognition of individual traits.

Assessing the ecological vulnerability of the upper reaches of the Minjiang River

PubMed Central

Sun, Jian; Ma, Baibing; Du, Wenpeng

2017-01-01

The upper reaches of the Minjiang River (URMR), located on the eastern edge of the Tibetan Plateau in southwestern China, are an important component of the ecological barrier of the Upper Yangtze River Basin. Climate change and human activities have increased the ecological sensitivity and vulnerability of the region, which may pose a threat to the ecological security of the Yangtze River Basin and have negative impacts on local social and economic development. In this study, we analyzed land use and cover change (LUCC) of the URMR between 2000 and 2010, and found that the total rate of LUCC was less than 0.50% during this period. In addition, net primary production (NPP) was employed to describe the changes in ecosystem sensitivity and vulnerability, and the results demonstrated that slightly and moderately sensitive and vulnerable zones occupied the largest area, distributed mainly in forest, shrub, and grassland ecosystems. However, compared with the period from 2000 to 2005, the ecological sensitivity and vulnerability showed a worsening trend in the period 2005–2010. Exploring the relationship between vulnerability/sensitivity and environmental factors, we found that sensitivity and vulnerability were positively correlated with precipitation (>700 mm) and aridity index (>36 mm/°C). The results highlight that the future ecological sensitivity and vulnerability of URMR should be further investigated, and that the LUCC induced by human activities and climate change have caused alteration of in ecosystem vulnerability. PMID:28753635

[Spatial and temporal changes of the ecological vulnerability in a serious soil erosion area, Southern China.

PubMed

Yao, Xiong; Yu, Kun Yong; Liu, Jian; Yang, Su Ping; He, Ping; Deng, Yang Bo; Yu, Xin Yan; Chen, Zhang Hao

2016-03-01

Research on eco-environment vulnerability assessment contributes to the ecological environmental conservation and restoration. With Changting County as the study area, this paper selec-ted 7 indicators including slope, soil type, multi-year average precipitation, elevation deviate degree, normalized difference vegetation index, population density and land use type to build ecological vulnerability assessment system by using multicollinearity diagnostics analysis approach. The quantitative assessment of ecological vulnerability in 1999, 2006 and 2014 was calculated by using entropy weight method and comprehensive index method. The changes of the temporal-spatial distribution of ecological vulnerability were also analyzed. The results showed that the ecological vulnerability level index (EVLI) decreased overall but increased locally from 1999 to 2014. The average EVLI values in 1999, 2006 and 2014 were 0.4533±0.1216, 0.4160±0.1111 and 0.3916±0.1139, respectively, indicating that the ecological vulnerability in Changting County was at the moderate grade. The EVLI decreased from 2.92 in 1999 to 2.38 in 2006 and 2.13 in 2014. The spatial distribution of the ecological vulnerability was high inside but low outside. The high vulnerability areas were distributed mainly in Hetian Town and Tingzhou Town, where the slope was less than 15° and the altitude was lower than 500 m. During the study period, Sanzhou Town had the largest decreasing range of EVLI while Tingzhou Town had the lowest.

Setting Priorities in Behavioral Interventions: An Application to Reducing Phishing Risk.

PubMed

Canfield, Casey Inez; Fischhoff, Baruch

2018-04-01

Phishing risk is a growing area of concern for corporations, governments, and individuals. Given the evidence that users vary widely in their vulnerability to phishing attacks, we demonstrate an approach for assessing the benefits and costs of interventions that target the most vulnerable users. Our approach uses Monte Carlo simulation to (1) identify which users were most vulnerable, in signal detection theory terms; (2) assess the proportion of system-level risk attributable to the most vulnerable users; (3) estimate the monetary benefit and cost of behavioral interventions targeting different vulnerability levels; and (4) evaluate the sensitivity of these results to whether the attacks involve random or spear phishing. Using parameter estimates from previous research, we find that the most vulnerable users were less cautious and less able to distinguish between phishing and legitimate emails (positive response bias and low sensitivity, in signal detection theory terms). They also accounted for a large share of phishing risk for both random and spear phishing attacks. Under these conditions, our analysis estimates much greater net benefit for behavioral interventions that target these vulnerable users. Within the range of the model's assumptions, there was generally net benefit even for the least vulnerable users. However, the differences in the return on investment for interventions with users with different degrees of vulnerability indicate the importance of measuring that performance, and letting it guide interventions. This study suggests that interventions to reduce response bias, rather than to increase sensitivity, have greater net benefit. © 2017 Society for Risk Analysis.

Reducing Cascading Failure Risk by Increasing Infrastructure Network Interdependence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Korkali, Mert; Veneman, Jason G.; Tivnan, Brian F.

Increased coupling between critical infrastructure networks, such as power and communication systems, has important implications for the reliability and security of these systems. To understand the effects of power-communication coupling, several researchers have studied models of interdependent networks and reported that increased coupling can increase vulnerability. However, these conclusions come largely from models that have substantially different mechanisms of cascading failure, relative to those found in actual power and communication networks, and that do not capture the benefits of connecting systems with complementary capabilities. In order to understand the importance of these details, this paper compares network vulnerability in simplemore » topological models and in models that more accurately capture the dynamics of cascading in power systems. First, we compare a simple model of topological contagion to a model of cascading in power systems and find that the power grid model shows a higher level of vulnerability, relative to the contagion model. Second, we compare a percolation model of topological cascading in coupled networks to three different models of power networks coupled to communication systems. Again, the more accurate models suggest very different conclusions than the percolation model. In all but the most extreme case, the physics-based power grid models indicate that increased power-communication coupling decreases vulnerability. This is opposite from what one would conclude from the percolation model, in which zero coupling is optimal. Only in an extreme case, in which communication failures immediately cause grid failures, did we find that increased coupling can be harmful. Together, these results suggest design strategies for reducing the risk of cascades in interdependent infrastructure systems.« less

Reducing Cascading Failure Risk by Increasing Infrastructure Network Interdependence

DOE PAGES

Korkali, Mert; Veneman, Jason G.; Tivnan, Brian F.; ...

2017-03-20

Increased coupling between critical infrastructure networks, such as power and communication systems, has important implications for the reliability and security of these systems. To understand the effects of power-communication coupling, several researchers have studied models of interdependent networks and reported that increased coupling can increase vulnerability. However, these conclusions come largely from models that have substantially different mechanisms of cascading failure, relative to those found in actual power and communication networks, and that do not capture the benefits of connecting systems with complementary capabilities. In order to understand the importance of these details, this paper compares network vulnerability in simplemore » topological models and in models that more accurately capture the dynamics of cascading in power systems. First, we compare a simple model of topological contagion to a model of cascading in power systems and find that the power grid model shows a higher level of vulnerability, relative to the contagion model. Second, we compare a percolation model of topological cascading in coupled networks to three different models of power networks coupled to communication systems. Again, the more accurate models suggest very different conclusions than the percolation model. In all but the most extreme case, the physics-based power grid models indicate that increased power-communication coupling decreases vulnerability. This is opposite from what one would conclude from the percolation model, in which zero coupling is optimal. Only in an extreme case, in which communication failures immediately cause grid failures, did we find that increased coupling can be harmful. Together, these results suggest design strategies for reducing the risk of cascades in interdependent infrastructure systems.« less

A Comparison of Petiole Hydraulics and Aquaporin Expression in an Anisohydric and Isohydric Cultivar of Grapevine in Response to Water-Stress Induced Cavitation.

PubMed

Shelden, Megan C; Vandeleur, Rebecca; Kaiser, Brent N; Tyerman, Stephen D

2017-01-01

We report physiological, anatomical and molecular differences in two economically important grapevine ( Vitis vinifera L.) cultivars cv. Grenache (near-isohydric) and Chardonnay (anisohydric) in their response to water-stress induced cavitation. The aim of the study was to compare organ vulnerability (petiole and stem) to cavitation by measuring ultrasonic acoustic emissions (UAE) and percent loss of conductance of potted grapevines subject to the onset of water-stress. Leaf (ψ L ) and stem water potential (ψ S ), stomatal conductance ( g s ), transpiration ( E ), petiole hydraulics ( K Pet ), and xylem diameter were also measured. Chardonnay displayed hydraulic segmentation based on UAE, with cavitation occurring at a less negative ψ L in the petiole than in the stem. Vulnerability segmentation was not observed in Grenache, with both petioles and stems equally vulnerable to cavitation. Leaf water potential that induced 50% of maximum UAE was significantly different between petioles and stems in Chardonnay (ψ 50Petiole = -1.14 and ψ 50Stem = -2.24 MPa) but not in Grenache (ψ 50Petiole = -0.73 and ψ 50Stem = -0.78 MPa). Grenache stems appeared more susceptible to water-stress induced cavitation than Chardonnay stems. Grenache displayed (on average) a higher K Pet likely due to the presence of larger xylem vessels. A close relationship between petiole hydraulic properties and vine water status was observed in Chardonnay but not in Grenache. Transcriptional analysis of aquaporins in the petioles and leaves ( VvPIP1;1, VvPIP2;1, VvPIP2;2 VvPIP2;3, VvTIP1;1 , and VvTIP2;1 ) showed differential regulation diurnally and in response to water-stress. VvPIP2;1 showed strong diurnal regulation in the petioles and leaves of both cultivars with expression highest predawn. Expression of VvPIP2;1 and VvPIP2;2 responded to ψ L and ψ S in both cultivars indicating the expression of these two genes are closely linked to vine water status. Expression of several aquaporin genes correlated with gas exchange measurements, however, these genes differed between cultivars. In summary, the data shows two contrasting responses in petiole hydraulics and aquaporin expression between the near-isohydric cultivar, Grenache and anisohydric cultivar, Chardonnay.

A Comparison of Petiole Hydraulics and Aquaporin Expression in an Anisohydric and Isohydric Cultivar of Grapevine in Response to Water-Stress Induced Cavitation

PubMed Central

Shelden, Megan C.; Vandeleur, Rebecca; Kaiser, Brent N.; Tyerman, Stephen D.

2017-01-01

We report physiological, anatomical and molecular differences in two economically important grapevine (Vitis vinifera L.) cultivars cv. Grenache (near-isohydric) and Chardonnay (anisohydric) in their response to water-stress induced cavitation. The aim of the study was to compare organ vulnerability (petiole and stem) to cavitation by measuring ultrasonic acoustic emissions (UAE) and percent loss of conductance of potted grapevines subject to the onset of water-stress. Leaf (ψL) and stem water potential (ψS), stomatal conductance (gs), transpiration (E), petiole hydraulics (KPet), and xylem diameter were also measured. Chardonnay displayed hydraulic segmentation based on UAE, with cavitation occurring at a less negative ψL in the petiole than in the stem. Vulnerability segmentation was not observed in Grenache, with both petioles and stems equally vulnerable to cavitation. Leaf water potential that induced 50% of maximum UAE was significantly different between petioles and stems in Chardonnay (ψ50Petiole = -1.14 and ψ50Stem = -2.24 MPa) but not in Grenache (ψ50Petiole = -0.73 and ψ50Stem = -0.78 MPa). Grenache stems appeared more susceptible to water-stress induced cavitation than Chardonnay stems. Grenache displayed (on average) a higher KPet likely due to the presence of larger xylem vessels. A close relationship between petiole hydraulic properties and vine water status was observed in Chardonnay but not in Grenache. Transcriptional analysis of aquaporins in the petioles and leaves (VvPIP1;1, VvPIP2;1, VvPIP2;2 VvPIP2;3, VvTIP1;1, and VvTIP2;1) showed differential regulation diurnally and in response to water-stress. VvPIP2;1 showed strong diurnal regulation in the petioles and leaves of both cultivars with expression highest predawn. Expression of VvPIP2;1 and VvPIP2;2 responded to ψL and ψS in both cultivars indicating the expression of these two genes are closely linked to vine water status. Expression of several aquaporin genes correlated with gas exchange measurements, however, these genes differed between cultivars. In summary, the data shows two contrasting responses in petiole hydraulics and aquaporin expression between the near-isohydric cultivar, Grenache and anisohydric cultivar, Chardonnay. PMID:29163613

Long-term effect on in vitro cloning efficiency after treatment of somatic cells with Xenopus egg extract in the pig.

PubMed

Liu, Ying; Ostrup, Olga; Li, Rong; Li, Juan; Vajta, Gábor; Kragh, Peter M; Schmidt, Mette; Purup, Stig; Hyttel, Poul; Klærke, Dan; Callesen, Henrik

2014-08-01

In somatic cell nuclear transfer (SCNT), donor cell reprogramming is considered as a biologically important and vulnerable event. Various donor cell pre-treatments with Xenopus egg extracts can promote reprogramming. Here we investigated if the reprogramming effect of one treatment with Xenopus egg extract on donor cells was maintained for several cell passages. The extract treatment resulted in increased cell-colony formation from early passages in treated porcine fibroblasts (ExTES), and increased development of cloned embryos. Partial dedifferentiation was observed in ExTES cells, shown as a tendency towards upregulation of NANOG, c-MYC and KLF-4 and downregulation of DESMIM compared with ExTES at Passage 2. Compared with our routine SCNT, continuously increased development of cloned embryos was observed in the ExTES group, and ExTES cloned blastocysts displayed hypermethylated DNA patterns and hypermethylation of H3K4me3 and H3K27me3 in ICM compared with TE. All seven recipients became pregnant after transferral of ExTES cloned embryos and gave birth to 7-22 piglets per litter (average 12). In conclusion, our results demonstrate that one treatment of porcine fibroblasts with Xenopus egg extract can result in long-term increased ability of the cells to promote their in vitro function in subsequent SCNT. Finally these cells can also result in successful development of cloned embryos to term.

Non-visual spatial tasks reveal increased interactions with stance postural control.

PubMed

Woollacott, Marjorie; Vander Velde, Timothy

2008-05-07

The current investigation aimed to contrast the level and quality of dual-task interactions resulting from the combined performance of a challenging primary postural task and three specific, yet categorically dissociated, secondary central executive tasks. Experiments determined the extent to which modality (visual vs. auditory) and code (non-spatial vs. spatial) specific cognitive resources contributed to postural interference in young adults (n=9) in a dual-task setting. We hypothesized that the different forms of executive n-back task processing employed (visual-object, auditory-object and auditory-spatial) would display contrasting levels of interactions with tandem Romberg stance postural control, and that interactions within the spatial domain would be revealed as most vulnerable to dual-task interactions. Across all cognitive tasks employed, including auditory-object (aOBJ), auditory-spatial (aSPA), and visual-object (vOBJ) tasks, increasing n-back task complexity produced correlated increases in verbal reaction time measures. Increasing cognitive task complexity also resulted in consistent decreases in judgment accuracy. Postural performance was significantly influenced by the type of cognitive loading delivered. At comparable levels of cognitive task difficulty (n-back demands and accuracy judgments) the performance of challenging auditory-spatial tasks produced significantly greater levels of postural sway than either the auditory-object or visual-object based tasks. These results suggest that it is the employment of limited non-visual spatially based coding resources that may underlie previously observed visual dual-task interference effects with stance postural control in healthy young adults.

Orphans and at-risk children in Haiti: vulnerabilities and human rights issues postearthquake.

PubMed

Nicholas, Patrice K; George, Erin K; Raymond, Nadia; Lewis-OʼConnor, Annie; Victoria, Stephanie; Lucien, Sergeline; Peters-Lewis, Angelleen; Hickey, Nancy; Corless, Inge B; Tyer-Viola, Lynda; Davis, Sheila M; Barry, Donna; Marcelin, Naomie; Valcourt, Roodeline

2012-01-01

The vulnerability of children in Haiti has increased dramatically since the earthquake in January 2010. Prior to the earthquake, the prevalence of orphans and at-risk children was high but since the earthquake, more than 1 million people-with more than 380,000 children remaining displaced and living in over 1200 displacement sites. These existing conditions leave orphans and at-risk children vulnerable to exploitation, abuse, and increased risk of HIV/AIDS. This article will focus on the complex issues affecting orphans and at-risk children and the intersection with HIV/AIDS and human rights. Specific recommendations by United Nations Children's Fund are discussed. Nursing in Haiti must address the policy-related and population-specific approaches for the care of children living with or affected by HIV/AIDS.

Vulnerability and risk in children living with a physical disability.

PubMed

Heaslip, Vanessa; Hewitt-Taylor, Jaqui

2014-12-01

Children are identified as a vulnerable group in need of a degree of safeguarding. About 6% of children in the UK have a disability, which can increase their level of vulnerability. How disability is perceived by others may affect the way they work with these young people in coping with life's risks, which may be increased due to the disability. Each individual's perception of the risks and benefits of a given venture varies. Children's nurses work with these young people and their families, aiming to give them maximum autonomy, self-reliance, empowerment and independence in adulthood. This involves risk-taking, as every young person needs to learn from graduated exposure to new experiences, environments, associations and hazards; the chance of harm must be balanced with the disadvantages of over-protection.

The impact of flooding on people living with HIV: a case study from the Ohangwena Region, Namibia

PubMed Central

Anthonj, Carmen; Nkongolo, Odon T.; Schmitz, Peter; Hango, Johannes N.; Kistemann, Thomas

2015-01-01

Background Floods are a disaster situation for all affected populations and especially for vulnerable groups within communities such as children, orphans, women, and people with chronic diseases such as HIV and AIDS. They need functioning health care, sanitation and hygiene, safe water, and healthy food supply, and are critically dependent on their social care and support networks. A study carried out in the Ohangwena region, Namibia, where HIV prevalence is high and extensive flooding frequently occurs, aims to provide a deeper understanding of the impact that flooding has on people living with HIV (PLWHIV) as well as on HIV service providers in the region. Design The qualitative research applying grounded theory included semi-structured interviews with PLWHIV, focus group discussions with HIV service providers, and a national feedback meeting. The findings were interpreted using the sustainable livelihoods framework, the natural hazard research approach, and health behaviour theories. Results The study reveals that flooding poses major problems to PLWHIV in terms of their everyday lives, affecting livelihoods, work, income, and living conditions. The factors threatening them under normal conditions – poverty, malnutrition, unsafe water, sanitation and hygiene, limited access to health facilities, a weak health status, and stigma – are intensified by flood-related breakdown of infrastructure, insecurity, malnutrition, and diseases evolving over the course of a flood. A potential dual risk exists for their health: the increased risk both of infection and disease due to the inaccessibility of health services and antiretroviral treatment. A HIV and Flooding Framework was developed to display the results. Conclusions This study demonstrates that vulnerabilities and health risks of PLWHIV will increase in a disaster situation like flooding if access to HIV prevention, treatment, care and support are not addressed and ensured. The findings and the HIV and Flooding Framework are not specific to Ohangwena and can be transferred to any flood-affected region that has a high HIV prevalence and relies mainly on subsistence agriculture. They serve as a model case for analysing vulnerabilities related to health and health service provision under disaster conditions. The impact will vary according to the physical, geographical, climatological, social, and behavioural characteristics of the region and the people affected. In the Ohangwena region, a disaster risk management mechanism is already in place which addresses people with HIV during flooding. However, preparedness could be improved further by applying the HIV and Flooding Framework. PMID:25813771

Topological Vulnerability Evaluation Model Based on Fractal Dimension of Complex Networks.

PubMed

Gou, Li; Wei, Bo; Sadiq, Rehan; Sadiq, Yong; Deng, Yong

2016-01-01

With an increasing emphasis on network security, much more attentions have been attracted to the vulnerability of complex networks. In this paper, the fractal dimension, which can reflect space-filling capacity of networks, is redefined as the origin moment of the edge betweenness to obtain a more reasonable evaluation of vulnerability. The proposed model combining multiple evaluation indexes not only overcomes the shortage of average edge betweenness's failing to evaluate vulnerability of some special networks, but also characterizes the topological structure and highlights the space-filling capacity of networks. The applications to six US airline networks illustrate the practicality and effectiveness of our proposed method, and the comparisons with three other commonly used methods further validate the superiority of our proposed method.

Vulnerability Analysis and Evaluation of Urban Road System in Tianjin

NASA Astrophysics Data System (ADS)

Liu, Y. Q.; Wu, X.

In recent years, with the development of economy, the road construction of our country has entered into a period of rapid growth. The road transportation network has been expanding and the risk of disasters is increasing. In this paper we study the vulnerability of urban road system in Tianjin. After analyzed many risk factors of the urban road system security, including road construction, road traffic and the natural environment, we proposed an evaluation index of vulnerability of urban road system and established the corresponding evaluation index system. Based on the results of analysis and comprehensive evaluation, appropriate improvement measures and suggestions which may reduce the vulnerability of the road system and improve the safety and reliability of the road system are proposed.

Vulnerability of drained and rewetted organic soils to climate change impacts and associated adaptation options

NASA Astrophysics Data System (ADS)

Renou-Wilson, Florence; Müller, Christoph; Wilson, David

2016-04-01

With 20% of the land covered with peat soils, Ireland needs to develop a deeper understanding among stakeholders of the potential vulnerability of peatlands and organic soils to climate change (both gradual and extreme events) in the context of current land use changes. The fate of carbon in organic soils is critical for predicting future greenhouse gas (GHG) concentrations in the atmosphere. While keeping carbon stock in organic soils (for example by rewetting drained sites) can be an effective mitigation measures to reduce CO2 emissions, adaptation options are also required to ensure their 'resilience'. Rewetting of drained organic soils has been initiated at several sites across the country with the aim to (i) reduce net GHG emissions at the source and/or (ii) create suitable conditions for carbon sequestration in active peatland habitats. We present here two sites: an industrial cutaway peatland and an extensive grassland over organic soil, where long-term (> 4 years) environmental and GHG flux (chamber) datasets in both drained and rewetted areas have provided information on the impact of annual weather variability on net ecosystem exchange (NEE). Statistical response functions estimated for gross primary production (GPP) and ecosystem respiration (Reco) were used to reconstruct annual CO2 balances using site-specific models driven by soil temperature, solar radiation, soil water table levels and leaf area index. The modification of some of the model parameters to fit predicted future climate scenarios for the region allowed potential changes in modelled NEE to be assessed. Both sites were, on average, an annual source of CO2 when drained (138 - 232 g C m-2 yr-1) and a sink when rewetted (ranging from -40 g C m-2 yr-1 in the ungrazed rewetted grassland to a maximum of -260 g C m-2 yr-1 in the rewetted cutaway). At both sites, soil temperatures and water table levels varied significantly between all years. Average NEE at each site displayed a very large standard deviation over the years suggesting a strong influence of external factors (weather variability) and vegetation change in some cases. Such wide variation in annual NEE values is not encountered in their natural counterparts within the same region. Under simulated moderate scenarios of (i) increased soil temperature (1° C) and (ii) deeper WT (-10cm) (both seasonal and/or annual), the rewetted areas always displayed a larger change (increase) in annual NEE compared to the drained areas. Furthermore, all rewetted sites became CO2 sources when both parameters were altered simultaneously over 4 years. Although positive feedbacks from vegetation may occur following such environmental changes, it is expected that the rewetted peatland areas will remain at risk under even moderate levels of climate change and may therefore require further intervention.

Let's Stop Trying to Quantify Household Vulnerability: The Problem With Simple Scales for Targeting and Evaluating Economic Strengthening Programs.

PubMed

Moret, Whitney M

2018-03-21

Economic strengthening practitioners are increasingly seeking data collection tools that will help them target households vulnerable to HIV and poor child well-being outcomes, match households to appropriate interventions, monitor their status, and determine readiness for graduation from project support. This article discusses efforts in 3 countries to develop simple, valid tools to quantify and classify economic vulnerability status. In Côte d'Ivoire, we conducted a cross-sectional survey with 3,749 households to develop a scale based on the definition of HIV-related economic vulnerability from the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) for the purpose of targeting vulnerable households for PEPFAR-funded programs for orphans and vulnerable children. The vulnerability measures examined did not cluster in ways that would allow for the creation of a small number of composite measures, and thus we were unable to develop a scale. In Uganda, we assessed the validity of a vulnerability index developed to classify households according to donor classifications of economic status by measuring its association with a validated poverty measure, finding only a modest correlation. In South Africa, we developed monitoring and evaluation tools to assess economic status of individual adolescent girls and their households. We found no significant correlation with our validation measures, which included a validated measure of girls' vulnerability to HIV, a validated poverty measure, and subjective classifications generated by the community, data collector, and respondent. Overall, none of the measures of economic vulnerability used in the 3 countries varied significantly with their proposed validation items. Our findings suggest that broad constructs of economic vulnerability cannot be readily captured using simple scales to classify households and individuals in a way that accounts for a substantial amount of variance at locally defined vulnerability levels. We recommend that researchers and implementers design monitoring and evaluation instruments to capture narrower definitions of vulnerability based on characteristics programs intend to affect. We also recommend using separate tools for targeting based on context-specific indicators with evidence-based links to negative outcomes. Policy makers and donors should avoid reliance on simplified metrics of economic vulnerability in the programs they support. © Moret.

Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys.

PubMed

Kanaan, Nicholas M; Kordower, Jeffrey H; Collier, Timothy J

2010-06-01

Aging remains the strongest risk factor for developing Parkinson's disease (PD), and there is selective vulnerability in midbrain dopamine (DA) neuron degeneration in PD. By tracking normal aging-related changes with an emphasis on regional specificity, factors involved in selective vulnerability and resistance to degeneration can be studied. Towards this end, we sought to determine whether age-related changes in microglia and astrocytes in rhesus monkeys are region-specific, suggestive of involvement in regional differences in vulnerability to degeneration that may be relevant to PD pathogenesis. Gliosis in midbrain DA subregions was measured by estimating glia number using unbiased stereology, assessing fluorescence intensity for proteins upregulated during activation, and rating morphology. With normal aging, microglia exhibited increased staining intensity and a shift to more activated morphologies preferentially in the vulnerable substantia nigra-ventral tier (vtSN). Astrocytes did not exhibit age-related changes consistent with an involvement in regional vulnerability in any measure. Our results suggest advancing age is associated with chronic mild inflammation in the vtSN, which may render these DA neurons more vulnerable to degeneration. Copyright 2008 Elsevier Inc. All rights reserved.

Evaluating social and ecological vulnerability of coral reef fisheries to climate change.

PubMed

Cinner, Joshua E; Huchery, Cindy; Darling, Emily S; Humphries, Austin T; Graham, Nicholas A J; Hicks, Christina C; Marshall, Nadine; McClanahan, Tim R

2013-01-01

There is an increasing need to evaluate the links between the social and ecological dimensions of human vulnerability to climate change. We use an empirical case study of 12 coastal communities and associated coral reefs in Kenya to assess and compare five key ecological and social components of the vulnerability of coastal social-ecological systems to temperature induced coral mortality [specifically: 1) environmental exposure; 2) ecological sensitivity; 3) ecological recovery potential; 4) social sensitivity; and 5) social adaptive capacity]. We examined whether ecological components of vulnerability varied between government operated no-take marine reserves, community-based reserves, and openly fished areas. Overall, fished sites were marginally more vulnerable than community-based and government marine reserves. Social sensitivity was indicated by the occupational composition of each community, including the importance of fishing relative to other occupations, as well as the susceptibility of different fishing gears to the effects of coral bleaching on target fish species. Key components of social adaptive capacity varied considerably between the communities. Together, these results show that different communities have relative strengths and weaknesses in terms of social-ecological vulnerability to climate change.

A Review of Intravascular Ultrasound–Based Multimodal Intravascular Imaging: The Synergistic Approach to Characterizing Vulnerable Plaques

PubMed Central

Ma, Teng; Zhou, Bill; Hsiai, Tzung K.; Shung, K. Kirk

2015-01-01

Catheter-based intravascular imaging modalities are being developed to visualize pathologies in coronary arteries, such as high-risk vulnerable atherosclerotic plaques known as thin-cap fibroatheroma, to guide therapeutic strategy at preventing heart attacks. Mounting evidences have shown three distinctive histopathological features—the presence of a thin fibrous cap, a lipid-rich necrotic core, and numerous infiltrating macrophages—are key markers of increased vulnerability in atherosclerotic plaques. To visualize these changes, the majority of catheter-based imaging modalities used intravascular ultrasound (IVUS) as the technical foundation and integrated emerging intravascular imaging techniques to enhance the characterization of vulnerable plaques. However, no current imaging technology is the unequivocal “gold standard” for the diagnosis of vulnerable atherosclerotic plaques. Each intravascular imaging technology possesses its own unique features that yield valuable information although encumbered by inherent limitations not seen in other modalities. In this context, the aim of this review is to discuss current scientific innovations, technical challenges, and prospective strategies in the development of IVUS-based multi-modality intravascular imaging systems aimed at assessing atherosclerotic plaque vulnerability. PMID:26400676

Vulnerability and Risk of Agro-ecosystems Facing Increased Salinity Intrusion in the Mekong Delta, Viet Nam

NASA Astrophysics Data System (ADS)

Renaud, F.; Sebesvari, Z.; Nguyen, M. T.; Hagenlocher, M.

2016-12-01

The Vietnamese portion of the Mekong Delta increasingly suffers from salinity intrusion in its freshwater system, as exemplified by the historically high salinity levels recorded during the 2016 dry season. Although this exceptional situation was linked to the El Niño phenomena, many factors contribute to an increasing salinization of coastal areas. Salinity intrusion is a natural process in this tidal area but its extent is increasing and projected to worsen due to increased demand for water, diversion/storage of water flows in the Mekong river and its tributaries, land subsidence linked to groundwater over-abstraction, changes in land use and water management in coastal areas, and sea level rise. The Mekong Delta remains predominantly an agricultural landscape which contributes the majority of the rice, aquaculture, and fruit production of the country. These systems will need to be adapted to increased salinity levels. We will present results from two research projects, DeltAdapt and DELTAS, which were designed to allow understanding of, respectively (1) the main drivers of change of agro-ecosystems in coastal areas of the delta and (2) the relative vulnerabilities and risks deltaic social-ecological systems face with respect to various environmental hazards. We used the Global Delta Vulnerability Index developed within the DELTAS project to characterize the vulnerabilities and risks faced by coastal provinces of the delta with respect to salinity intrusion. The analysis allows us to understand which social, economic, and ecological variables index explain the relative vulnerability of the provinces. In addition, drivers of change (e.g. policy, economic, social, environmental) of coastal agro-ecosystems were systematically analyzed through 80 interviews and 7 focus group discussions in the provinces of Kien Giang and Soc Trang within the DeltAdapt project. This was combined with the analysis of Vietnamese policies to determine which are the important drivers of change in the region and how these contribute (or not) to the adaptation of agro-ecosystems facing increased salinity intrusion. By combining these results, we will point to potential policies that could be considered by various authorities to allow for a greater adaptability of agro-ecosystems in the coastal provinces of the region.

Characterization of Vulnerable and Resilient Spanish Adolescents in Their Developmental Contexts

PubMed Central

Moreno, Carmen; García-Moya, Irene; Rivera, Francisco; Ramos, Pilar

2016-01-01

Research on resilience and vulnerability can offer very valuable information for optimizing design and assessment of interventions and policies aimed at fostering adolescent health. This paper used the adversity level associated with family functioning and the positive adaptation level, as measured by means of a global health score, to distinguish four groups within a representative sample of Spanish adolescents aged 13–16 years: maladaptive, resilient, competent and vulnerable. The aforementioned groups were compared in a number of demographic, school context, peer context, lifestyles, psychological and socioeconomic variables, which can facilitate or inhibit positive adaptation in each context. In addition, the degree to which each factor tended to associate with resilience and vulnerability was examined. The majority of the factors operated by increasing the likelihood of good adaptation in resilient adolescents and diminishing it in vulnerable ones. Overall, more similarities than differences were found in the factors contributing to explaining resilience or vulnerability. However, results also revealed some differential aspects: psychological variables showed a larger explicative capacity in vulnerable adolescents, whereas factors related to school and peer contexts, especially the second, showed a stronger association with resilience. In addition, perceived family wealth, satisfaction with friendships and breakfast frequency only made a significant contribution to the explanation of resilience. The current study provides a highly useful characterization of resilience and vulnerability phenomena in adolescence. PMID:27458397

Modeling Coastal Vulnerability through Space and Time.

PubMed

Hopper, Thomas; Meixler, Marcia S

2016-01-01

Coastal ecosystems experience a wide range of stressors including wave forces, storm surge, sea-level rise, and anthropogenic modification and are thus vulnerable to erosion. Urban coastal ecosystems are especially important due to the large populations these limited ecosystems serve. However, few studies have addressed the issue of urban coastal vulnerability at the landscape scale with spatial data that are finely resolved. The purpose of this study was to model and map coastal vulnerability and the role of natural habitats in reducing vulnerability in Jamaica Bay, New York, in terms of nine coastal vulnerability metrics (relief, wave exposure, geomorphology, natural habitats, exposure, exposure with no habitat, habitat role, erodible shoreline, and surge) under past (1609), current (2015), and future (2080) scenarios using InVEST 3.2.0. We analyzed vulnerability results both spatially and across all time periods, by stakeholder (ownership) and by distance to damage from Hurricane Sandy. We found significant differences in vulnerability metrics between past, current and future scenarios for all nine metrics except relief and wave exposure. The marsh islands in the center of the bay are currently vulnerable. In the future, these islands will likely be inundated, placing additional areas of the shoreline increasingly at risk. Significant differences in vulnerability exist between stakeholders; the Breezy Point Cooperative and Gateway National Recreation Area had the largest erodible shoreline segments. Significant correlations exist for all vulnerability (exposure/surge) and storm damage combinations except for exposure and distance to artificial debris. Coastal protective features, ranging from storm surge barriers and levees to natural features (e.g. wetlands), have been promoted to decrease future flood risk to communities in coastal areas around the world. Our methods of combining coastal vulnerability results with additional data and across multiple time periods have considerable potential to provide valuable predictions that resource managers can effectively use to identify areas for restoration and protection.

Modeling Coastal Vulnerability through Space and Time

PubMed Central

2016-01-01

Coastal ecosystems experience a wide range of stressors including wave forces, storm surge, sea-level rise, and anthropogenic modification and are thus vulnerable to erosion. Urban coastal ecosystems are especially important due to the large populations these limited ecosystems serve. However, few studies have addressed the issue of urban coastal vulnerability at the landscape scale with spatial data that are finely resolved. The purpose of this study was to model and map coastal vulnerability and the role of natural habitats in reducing vulnerability in Jamaica Bay, New York, in terms of nine coastal vulnerability metrics (relief, wave exposure, geomorphology, natural habitats, exposure, exposure with no habitat, habitat role, erodible shoreline, and surge) under past (1609), current (2015), and future (2080) scenarios using InVEST 3.2.0. We analyzed vulnerability results both spatially and across all time periods, by stakeholder (ownership) and by distance to damage from Hurricane Sandy. We found significant differences in vulnerability metrics between past, current and future scenarios for all nine metrics except relief and wave exposure. The marsh islands in the center of the bay are currently vulnerable. In the future, these islands will likely be inundated, placing additional areas of the shoreline increasingly at risk. Significant differences in vulnerability exist between stakeholders; the Breezy Point Cooperative and Gateway National Recreation Area had the largest erodible shoreline segments. Significant correlations exist for all vulnerability (exposure/surge) and storm damage combinations except for exposure and distance to artificial debris. Coastal protective features, ranging from storm surge barriers and levees to natural features (e.g. wetlands), have been promoted to decrease future flood risk to communities in coastal areas around the world. Our methods of combining coastal vulnerability results with additional data and across multiple time periods have considerable potential to provide valuable predictions that resource managers can effectively use to identify areas for restoration and protection. PMID:27732674

Climate change vulnerability of native and alien freshwater fishes of California: a systematic assessment approach.

PubMed

Moyle, Peter B; Kiernan, Joseph D; Crain, Patrick K; Quiñones, Rebecca M

2013-01-01

Freshwater fishes are highly vulnerable to human-caused climate change. Because quantitative data on status and trends are unavailable for most fish species, a systematic assessment approach that incorporates expert knowledge was developed to determine status and future vulnerability to climate change of freshwater fishes in California, USA. The method uses expert knowledge, supported by literature reviews of status and biology of the fishes, to score ten metrics for both (1) current status of each species (baseline vulnerability to extinction) and (2) likely future impacts of climate change (vulnerability to extinction). Baseline and climate change vulnerability scores were derived for 121 native and 43 alien fish species. The two scores were highly correlated and were concordant among different scorers. Native species had both greater baseline and greater climate change vulnerability than did alien species. Fifty percent of California's native fish fauna was assessed as having critical or high baseline vulnerability to extinction whereas all alien species were classified as being less or least vulnerable. For vulnerability to climate change, 82% of native species were classified as highly vulnerable, compared with only 19% for aliens. Predicted climate change effects on freshwater environments will dramatically change the fish fauna of California. Most native fishes will suffer population declines and become more restricted in their distributions; some will likely be driven to extinction. Fishes requiring cold water (<22°C) are particularly likely to go extinct. In contrast, most alien fishes will thrive, with some species increasing in abundance and range. However, a few alien species will likewise be negatively affected through loss of aquatic habitats during severe droughts and physiologically stressful conditions present in most waterways during summer. Our method has high utility for predicting vulnerability to climate change of diverse fish species. It should be useful for setting conservation priorities in many different regions.

Climate Change Vulnerability of Native and Alien Freshwater Fishes of California: A Systematic Assessment Approach

PubMed Central

Moyle, Peter B.; Kiernan, Joseph D.; Crain, Patrick K.; Quiñones, Rebecca M.

2013-01-01

Freshwater fishes are highly vulnerable to human-caused climate change. Because quantitative data on status and trends are unavailable for most fish species, a systematic assessment approach that incorporates expert knowledge was developed to determine status and future vulnerability to climate change of freshwater fishes in California, USA. The method uses expert knowledge, supported by literature reviews of status and biology of the fishes, to score ten metrics for both (1) current status of each species (baseline vulnerability to extinction) and (2) likely future impacts of climate change (vulnerability to extinction). Baseline and climate change vulnerability scores were derived for 121 native and 43 alien fish species. The two scores were highly correlated and were concordant among different scorers. Native species had both greater baseline and greater climate change vulnerability than did alien species. Fifty percent of California’s native fish fauna was assessed as having critical or high baseline vulnerability to extinction whereas all alien species were classified as being less or least vulnerable. For vulnerability to climate change, 82% of native species were classified as highly vulnerable, compared with only 19% for aliens. Predicted climate change effects on freshwater environments will dramatically change the fish fauna of California. Most native fishes will suffer population declines and become more restricted in their distributions; some will likely be driven to extinction. Fishes requiring cold water (<22°C) are particularly likely to go extinct. In contrast, most alien fishes will thrive, with some species increasing in abundance and range. However, a few alien species will likewise be negatively affected through loss of aquatic habitats during severe droughts and physiologically stressful conditions present in most waterways during summer. Our method has high utility for predicting vulnerability to climate change of diverse fish species. It should be useful for setting conservation priorities in many different regions. PMID:23717503

Paint it Black: Using Change-Point Analysis to Investigate Increasing Vulnerability to Depression towards the End of Vincent van Gogh's Life.

PubMed

van Emmerik, Arnold A P; Hamaker, Ellen L

2017-09-04

This study investigated whether Vincent van Gogh became increasingly self-focused-and thus vulnerable to depression-towards the end of his life, through a quantitative analysis of his written pronoun use over time. A change-point analysis was conducted on the time series formed by the pronoun use in Van Gogh's letters. We used time as a predictor to see whether there was evidence for increased self-focus towards the end of Van Gogh's life, and we compared this to the pattern in the letters written before his move to Arles. Specifically, we examined Van Gogh's use of first person singular pronouns (FPSP) and first person plural pronouns (FPPP) in the 415 letters he wrote while working as an artist before his move to Arles, and in the next 248 letters he wrote after his move to Arles until his death in Auvers-sur-Oise. During the latter period, Van Gogh's use of FPSP showed an annual increase of 0.68% ( SE = 0.15, p < 0.001) and his use of FPPP showed an annual decrease of 0.23% ( SE = 0.04, p < 0.001), indicating increasing self-focus and vulnerability to depression. This trend differed from Van Gogh's pronoun use in the former period (which showed no significant trend in FPSP, and an annual increase of FPPP of 0.03%, SE = 0.02, p = 0.04). This study suggests that Van Gogh's death was preceded by a gradually increasing self-focus and vulnerability to depression. It also illustrates how existing methods (i.e., quantitative linguistic analysis and change-point analysis) can be combined to study specific research questions in innovative ways.

Paint it Black: Using Change-Point Analysis to Investigate Increasing Vulnerability to Depression towards the End of Vincent van Gogh’s Life

PubMed Central

van Emmerik, Arnold A. P.; Hamaker, Ellen L.

2017-01-01

This study investigated whether Vincent van Gogh became increasingly self-focused—and thus vulnerable to depression—towards the end of his life, through a quantitative analysis of his written pronoun use over time. A change-point analysis was conducted on the time series formed by the pronoun use in Van Gogh’s letters. We used time as a predictor to see whether there was evidence for increased self-focus towards the end of Van Gogh’s life, and we compared this to the pattern in the letters written before his move to Arles. Specifically, we examined Van Gogh’s use of first person singular pronouns (FPSP) and first person plural pronouns (FPPP) in the 415 letters he wrote while working as an artist before his move to Arles, and in the next 248 letters he wrote after his move to Arles until his death in Auvers-sur-Oise. During the latter period, Van Gogh’s use of FPSP showed an annual increase of 0.68% (SE = 0.15, p < 0.001) and his use of FPPP showed an annual decrease of 0.23% (SE = 0.04, p < 0.001), indicating increasing self-focus and vulnerability to depression. This trend differed from Van Gogh’s pronoun use in the former period (which showed no significant trend in FPSP, and an annual increase of FPPP of 0.03%, SE = 0.02, p = 0.04). This study suggests that Van Gogh’s death was preceded by a gradually increasing self-focus and vulnerability to depression. It also illustrates how existing methods (i.e., quantitative linguistic analysis and change-point analysis) can be combined to study specific research questions in innovative ways. PMID:28869542

Determination of depth-viewing volumes for stereo three-dimensional graphic displays

NASA Technical Reports Server (NTRS)

Parrish, Russell V.; Williams, Steven P.

1990-01-01

Real-world, 3-D, pictorial displays incorporating true depth cues via stereopsis techniques offer a potential means of displaying complex information in a natural way to prevent loss of situational awareness and provide increases in pilot/vehicle performance in advanced flight display concepts. Optimal use of stereopsis requires an understanding of the depth viewing volume available to the display designer. Suggested guidelines are presented for the depth viewing volume from an empirical determination of the effective region of stereopsis cueing (at several viewer-CRT screen distances) for a time multiplexed stereopsis display system. The results provide the display designer with information that will allow more effective placement of depth information to enable the full exploitation of stereopsis cueing. Increasing viewer-CRT screen distances provides increasing amounts of usable depth, but with decreasing fields-of-view. A stereopsis hardware system that permits an increased viewer-screen distance by incorporating larger screen sizes or collimation optics to maintain the field-of-view at required levels would provide a much larger stereo depth-viewing volume.

Species-specific vulnerability of benthic marine embryos of congeneric snails (Haminoea spp.) to ultraviolet radiation and other intertidal stressors.

PubMed

Russell, Janine; Phillips, Nicole

2009-08-01

We used field surveys and multi-factorial experiments to examine synergistic effects of ultraviolet radiation (UVR) and low tide conditions on the embryonic mortality of two bubble-shell snail species that deposit gelatinous egg masses in intertidal mudflats: Haminoea zelandiae from New Zealand, and Haminoea vesicula from Washington, USA. Egg masses of both species were predominantly found in shallow pools at low tide, and a substantial proportion of both were found in sunny as well as shaded microhabitats. Both exposure to sun and desiccation led to increased embryonic mortality for naturally deposited egg masses of H. zelandiae compared to those that were shaded or submerged. For H. vesicula, although mortality was double for embryos within desiccated egg masses, there was no additional mortality due to sun exposure. In manipulative experiments, UVR and low tide conditions increased embryonic mortality for both species; however, H. zelandiae appeared to be more vulnerable to UVR, whereas H. vesicula was particularly vulnerable to desiccation. Simulated tidal pool conditions significantly increased mortality only for H. vesicula. These results suggest an important role of species-specific differences in vulnerability to different stressors, even for ecologically similar congeners; here, these differences may be related to development time or egg mass characteristics.

The vulnerability and resilience of a city's water footprint: The case of Flagstaff, Arizona, USA

NASA Astrophysics Data System (ADS)

Rushforth, Richard R.; Ruddell, Benjamin L.

2016-04-01

Research has yet to operationalize water footprint information for urban water policy and planning to reduce vulnerability and increase resilience to water scarcity. Using a county-level database of the U.S. hydro-economy, NWED, we spatially mapped and analyzed the Water Footprint of Flagstaff, Arizona, a small city. Virtual water inflow and outflow networks were developed using the flow of commodities into and out of the city. The power law distribution of virtual water trade volume between Flagstaff and its county trading partners broke at a spatial distance of roughly 2000 km. Most large trading partners are within this geographical distance, and this distance is an objective definition for Flagstaff's zone of indirect hydro-economic influence—that is, its water resource hinterland. Metrics were developed to measure Flagstaff's reliance on virtual water resources, versus direct use of local physical water resources. Flagstaff's reliance on external water supplies via virtual water trade increases both its hydro-economic resilience and vulnerability to water scarcity. These methods empower city managers to operationalize the city's Water Footprint information to reduce vulnerability, increase resilience, and optimally balance the allocation of local physical water supplies with the outsourcing of some water uses via the virtual water supply chain.

Relations of Physical Activity and Stress Vulnerability in University Students

ERIC Educational Resources Information Center

Xu, Furong; Liu, Wenhao; Chepyator-Thomson, Jepkorir Rose; Schmidlein, Robert

2018-01-01

There are increased concerns about depression and anxiety among college students. Thus in need of actions to find proper intervention strategies to target this issue. The purpose of this study was to examine association between leisure-time physical activity and stress vulnerability among college students. A modified survey including physical…

Our Shared Future: Social Media, Leadership, Vulnerability, and Digital Identity

ERIC Educational Resources Information Center

Stoller, Eric

2013-01-01

Social media have challenged us in our journey to support our students. Administrators have entered into new web-based conversations with one another and with their students. Personal branding has created a sense of performativity that conflicts with a growing trend towards online vulnerability. Our leaders have increasingly been engaged in…

Density-dependent vulnerability of forest ecosystems to drought

Treesearch

Alessandra Bottero; Anthony W. D' Amato; Brian J. Palik; John B. Bradford; Shawn Fraver; Mike A. Battaglia; Lance A. Asherin; Harald Bugmann

2017-01-01

Climate models predict increasing drought intensity and frequency for many regions, which may have negative consequences for tree recruitment, growth and mortality, as well as forest ecosystem services. Furthermore, practical strategies for minimizing vulnerability to drought are limited. Tree population density, a metric of tree abundance in a given area, is a primary...

Development and Initial Examination of a Brief Intervention for Heightened Anxiety Sensitivity among Heroin Users

ERIC Educational Resources Information Center

Tull, Matthew T.; Schulzinger, David; Schmidt, Norman B.; Zvolensky, Michael J.; Lejuez, C. W.

2007-01-01

Anxiety sensitivity (AS) recently has been identified as a potential cognitive vulnerability underlying substance use problems, with some evidence specifically indicating its relevance to heroin. Focusing on the potential utility of interventions centered on increasing willingness to have anxiety-related sensations reduce vulnerability for relapse…

Psychological Distress and Mortality: Are Women More Vulnerable?

ERIC Educational Resources Information Center

Ferraro, Kenneth F.; Nuriddin, Tariqah A.

2006-01-01

Does psychological distress increase mortality risk? If it does, are women more vulnerable than men to the effect of distress on mortality? Drawing from cumulative disadvantage theory, these questions are addressed with data from a 20-year follow-up of a national sample of adults ages 25-74. Event history analyses were performed to examine…

Exploring the Dynamics of Globalization: Supply Chain Vulnerability to Natural Disasters

ERIC Educational Resources Information Center

Kalafsky, Ronald V.; Conner, Neil

2015-01-01

Global supply chains play an increasingly important role in the economy and should therefore be addressed within geography coursework, especially given concerns that geographers have not fully explored various angles of globalization. This article explores the use of an online case study on supply chains and their vulnerability to natural…

Literacy Changes Lives 2014: A New Perspective on Health, Employment and Crime

ERIC Educational Resources Information Center

Morrisroe, Joe

2014-01-01

Since 2008, the financial crisis has had a profound social and economic impact on the UK's most vulnerable communities. Literacy influences individual capability in all spheres of life. In times of economic instability, low literacy makes individuals and communities more vulnerable to inequality, increasing the risk of social exclusion and…

Toward scientific equity for the prevention of depression and depressive symptoms in vulnerable youth.

PubMed

Perrino, Tatiana; Beardslee, William; Bernal, Guillermo; Brincks, Ahnalee; Cruden, Gracelyn; Howe, George; Murry, Velma; Pantin, Hilda; Prado, Guillermo; Sandler, Irwin; Brown, C Hendricks

2015-07-01

Certain subgroups of youth are at high risk for depression and elevated depressive symptoms, and experience limited access to quality mental health care. Examples are socioeconomically disadvantaged, racial/ethnic minority, and sexual minority youth. Research shows that there are efficacious interventions to prevent youth depression and depressive symptoms. These preventive interventions have the potential to play a key role in addressing these mental health disparities by reducing youth risk factors and enhancing protective factors. However, there are comparatively few preventive interventions directed specifically to these vulnerable subgroups, and sample sizes of diverse subgroups in general prevention trials are often too low to assess whether preventive interventions work equally well for vulnerable youth compared to other youth. In this paper, we describe the importance and need for "scientific equity," or equality and fairness in the amount of scientific knowledge produced to understand the potential solutions to such health disparities. We highlight possible strategies for promoting scientific equity, including the following: increasing the number of prevention research participants from vulnerable subgroups, conducting more data synthesis analyses and implementation science research, disseminating preventive interventions that are efficacious for vulnerable youth, and increasing the diversity of the prevention science research workforce. These strategies can increase the availability of research evidence to determine the degree to which preventive interventions can help address mental health disparities. Although this paper utilizes the prevention of youth depression as an illustrative case example, the concepts are applicable to other health outcomes for which there are disparities, such as substance use and obesity.

How to reduce the vulnerability of properties threatened by flood?

NASA Astrophysics Data System (ADS)

Vinet, Freddy; Leone, Frederic; Pelletier, Hugo; Queral, Fanny

2010-05-01

Over the last 20 or 30 years, increasing flood damage has compelled stakeholders to reconsider flood prevention. Indeed, the increase in damage emphasizes the failure of the current flood management policies based on river channel management instead of the mitigation of the flood risk. In the aftermath of the recent disasters in France and Europe, national and local authorities fostered an increasing number of initiatives geared towards reducing risks and rectifying the way of managing flood risks. All experts are now convinced that we must reduce risk through the mitigation of vulnerability. In this purpose, the French government and some river basin authorities try to develop programmes and laws intended to reduce the vulnerability of flood-prone buildings, mostly by retrofitting them. Through the results of field studies conducted in France, this presentation focuses on pros and cons of retrofitting. As of now, if many assessment of the vulnerability of buildings have been conducted, only a few huge retrofitting programmes have actually been implemented. Many bottlenecks emerge when implementing concrete measures. These difficulties include technical problems, cost, and the reluctance of many property owners... On the long run, retrofitting may be an efficient way to prevent damage to buildings threatened by floodwater. However current programmes fail to address the specificities of the local context in which such actions are implemented, e.g. accurate appraisal of flooding conditions, awareness of risk, vulnerability of people... The key is to involve all local actors including people threatened by flooding rather than to impose general and inappropriate measures.