Sample records for distance constraint model

  1. Model-independent constraints on possible modifications of Newtonian gravity

    NASA Technical Reports Server (NTRS)

    Talmadge, C.; Berthias, J.-P.; Hellings, R. W.; Standish, E. M.

    1988-01-01

    New model-independent constraints on possible modifications of Newtonian gravity over solar-system distance scales are presented, and their implications discussed. The constraints arise from the analysis of various planetary astrometric data sets. The results of the model-independent analysis are then applied to set limits on a variation in the l/r-squared behavior of gravity, on possible Yukawa-type interactions with ranges of the order of planetary distance scales, and on a deviation from Newtonian gravity of the type discussed by Milgrom (1983).

  2. An automated method for modeling proteins on known templates using distance geometry.

    PubMed

    Srinivasan, S; March, C J; Sudarsanam, S

    1993-02-01

    We present an automated method incorporated into a software package, FOLDER, to fold a protein sequence on a given three-dimensional (3D) template. Starting with the sequence alignment of a family of homologous proteins, tertiary structures are modeled using the known 3D structure of one member of the family as a template. Homologous interatomic distances from the template are used as constraints. For nonhomologous regions in the model protein, the lower and the upper bounds for the interatomic distances are imposed by steric constraints and the globular dimensions of the template, respectively. Distance geometry is used to embed an ensemble of structures consistent with these distance bounds. Structures are selected from this ensemble based on minimal distance error criteria, after a penalty function optimization step. These structures are then refined using energy optimization methods. The method is tested by simulating the alpha-chain of horse hemoglobin using the alpha-chain of human hemoglobin as the template and by comparing the generated models with the crystal structure of the alpha-chain of horse hemoglobin. We also test the packing efficiency of this method by reconstructing the atomic positions of the interior side chains beyond C beta atoms of a protein domain from a known 3D structure. In both test cases, models retain the template constraints and any additionally imposed constraints while the packing of the interior residues is optimized with no short contacts or bond deformations. To demonstrate the use of this method in simulating structures of proteins with nonhomologous disulfides, we construct a model of murine interleukin (IL)-4 using the NMR structure of human IL-4 as the template. The resulting geometry of the nonhomologous disulfide in the model structure for murine IL-4 is consistent with standard disulfide geometry.

  3. Cosmological effects of scalar-photon couplings: dark energy and varying-α Models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Avgoustidis, A.; Martins, C.J.A.P.; Monteiro, A.M.R.V.L.

    2014-06-01

    We study cosmological models involving scalar fields coupled to radiation and discuss their effect on the redshift evolution of the cosmic microwave background temperature, focusing on links with varying fundamental constants and dynamical dark energy. We quantify how allowing for the coupling of scalar fields to photons, and its important effect on luminosity distances, weakens current and future constraints on cosmological parameters. In particular, for evolving dark energy models, joint constraints on the dark energy equation of state combining BAO radial distance and SN luminosity distance determinations, will be strongly dominated by BAO. Thus, to fully exploit future SN datamore » one must also independently constrain photon number non-conservation arising from the possible coupling of SN photons to the dark energy scalar field. We discuss how observational determinations of the background temperature at different redshifts can, in combination with distance measures data, set tight constraints on interactions between scalar fields and photons, thus breaking this degeneracy. We also discuss prospects for future improvements, particularly in the context of Euclid and the E-ELT and show that Euclid can, even on its own, provide useful dark energy constraints while allowing for photon number non-conservation.« less

  4. Modeling protein conformational changes by iterative fitting of distance constraints using reoriented normal modes.

    PubMed

    Zheng, Wenjun; Brooks, Bernard R

    2006-06-15

    Recently we have developed a normal-modes-based algorithm that predicts the direction of protein conformational changes given the initial state crystal structure together with a small number of pairwise distance constraints for the end state. Here we significantly extend this method to accurately model both the direction and amplitude of protein conformational changes. The new protocol implements a multisteps search in the conformational space that is driven by iteratively minimizing the error of fitting the given distance constraints and simultaneously enforcing the restraint of low elastic energy. At each step, an incremental structural displacement is computed as a linear combination of the lowest 10 normal modes derived from an elastic network model, whose eigenvectors are reorientated to correct for the distortions caused by the structural displacements in the previous steps. We test this method on a list of 16 pairs of protein structures for which relatively large conformational changes are observed (root mean square deviation >3 angstroms), using up to 10 pairwise distance constraints selected by a fluctuation analysis of the initial state structures. This method has achieved a near-optimal performance in almost all cases, and in many cases the final structural models lie within root mean square deviation of 1 approximately 2 angstroms from the native end state structures.

  5. Fluence map optimization (FMO) with dose-volume constraints in IMRT using the geometric distance sorting method.

    PubMed

    Lan, Yihua; Li, Cunhua; Ren, Haozheng; Zhang, Yong; Min, Zhifang

    2012-10-21

    A new heuristic algorithm based on the so-called geometric distance sorting technique is proposed for solving the fluence map optimization with dose-volume constraints which is one of the most essential tasks for inverse planning in IMRT. The framework of the proposed method is basically an iterative process which begins with a simple linear constrained quadratic optimization model without considering any dose-volume constraints, and then the dose constraints for the voxels violating the dose-volume constraints are gradually added into the quadratic optimization model step by step until all the dose-volume constraints are satisfied. In each iteration step, an interior point method is adopted to solve each new linear constrained quadratic programming. For choosing the proper candidate voxels for the current dose constraint adding, a so-called geometric distance defined in the transformed standard quadratic form of the fluence map optimization model was used to guide the selection of the voxels. The new geometric distance sorting technique can mostly reduce the unexpected increase of the objective function value caused inevitably by the constraint adding. It can be regarded as an upgrading to the traditional dose sorting technique. The geometry explanation for the proposed method is also given and a proposition is proved to support our heuristic idea. In addition, a smart constraint adding/deleting strategy is designed to ensure a stable iteration convergence. The new algorithm is tested on four cases including head-neck, a prostate, a lung and an oropharyngeal, and compared with the algorithm based on the traditional dose sorting technique. Experimental results showed that the proposed method is more suitable for guiding the selection of new constraints than the traditional dose sorting method, especially for the cases whose target regions are in non-convex shapes. It is a more efficient optimization technique to some extent for choosing constraints than the dose sorting method. By integrating a smart constraint adding/deleting scheme within the iteration framework, the new technique builds up an improved algorithm for solving the fluence map optimization with dose-volume constraints.

  6. Directional output distance functions: endogenous directions based on exogenous normalization constraints

    USDA-ARS?s Scientific Manuscript database

    In this paper we develop a model for computing directional output distance functions with endogenously determined direction vectors. We show how this model is related to the slacks-based directional distance function introduced by Fare and Grosskopf and show how to use the slacks-based function to e...

  7. Models of red giants in the CoRoT asteroseismology fields combining asteroseismic and spectroscopic constraints - The open cluster NGC 6633 and field stars-

    NASA Astrophysics Data System (ADS)

    Lagarde, Nadège; Miglio, Andrea; Eggenberger, Patrick; Morel, Thierry; Montalbàn, Josefina; Mosser, Benoit

    2015-08-01

    The availability of asteroseismic constraints for a large sample of red giant stars from the CoRoT and Kepler missions paves the way for various statistical studies of the seismic properties of stellar populations.We use the first detailed spectroscopic study of CoRoT red-giant stars (Morel et al 2014) to compare theoretical stellar evolution models to observations of the open cluster NGC 6633 and field stars.In order to explore the effects of rotation-induced mixing and thermohaline instability, we compare surface abundances of carbon isotopic ratio and lithium with stellar evolution predictions. These chemicals are sensitive to extra-mixing on the red-giant branch.We estimate mass, radius, and distance for each star using the seismic constraints. We note that the Hipparcos and seismic distances are different. However, the uncertainties are such that this may not be significant. Although the seismic distances for the cluster members are self consistent they are somewhat larger than the Hipparcos distance. This is an issue that should be considered elsewhere. Models including thermohaline instability and rotation-induced mixing, together with the seismically determined masses can explain the chemical properties of red-giants targets. Tighter constraints on the physics of the models would be possible if there were detailed knowledge of the core rotation rate and the asymptotic period spacing.

  8. Knowledge-based versus experimentally acquired distance and angle constraints for NMR structure refinement.

    PubMed

    Cui, Feng; Jernigan, Robert; Wu, Zhijun

    2008-04-01

    Nuclear Overhauser effects (NOE) distance constraints and torsion angle constraints are major conformational constraints for nuclear magnetic resonance (NMR) structure refinement. In particular, the number of NOE constraints has been considered as an important determinant for the quality of NMR structures. Of course, the availability of torsion angle constraints is also critical for the formation of correct local conformations. In our recent work, we have shown how a set of knowledge-based short-range distance constraints can also be utilized for NMR structure refinement, as a complementary set of conformational constraints to the NOE and torsion angle constraints. In this paper, we show the results from a series of structure refinement experiments by using different types of conformational constraints--NOE, torsion angle, or knowledge-based constraints--or their combinations, and make a quantitative assessment on how the experimentally acquired constraints contribute to the quality of structural models and whether or not they can be combined with or substituted by the knowledge-based constraints. We have carried out the experiments on a small set of NMR structures. Our preliminary calculations have revealed that the torsion angle constraints contribute substantially to the quality of the structures, but require to be combined with the NOE constraints to be fully effective. The knowledge-based constraints can be functionally as crucial as the torsion angle constraints, although they are statistical constraints after all and are not meant to be able to replace the latter.

  9. Crosslinking Constraints and Computational Models as Complementary Tools in Modeling the Extracellular Domain of the Glycine Receptor

    PubMed Central

    Liu, Zhenyu; Szarecka, Agnieszka; Yonkunas, Michael; Speranskiy, Kirill; Kurnikova, Maria; Cascio, Michael

    2014-01-01

    The glycine receptor (GlyR), a member of the pentameric ligand-gated ion channel superfamily, is the major inhibitory neurotransmitter-gated receptor in the spinal cord and brainstem. In these receptors, the extracellular domain binds agonists, antagonists and various other modulatory ligands that act allosterically to modulate receptor function. The structures of homologous receptors and binding proteins provide templates for modeling of the ligand-binding domain of GlyR, but limitations in sequence homology and structure resolution impact on modeling studies. The determination of distance constraints via chemical crosslinking studies coupled with mass spectrometry can provide additional structural information to aid in model refinement, however it is critical to be able to distinguish between intra- and inter-subunit constraints. In this report we model the structure of GlyBP, a structural and functional homolog of the extracellular domain of human homomeric α1 GlyR. We then show that intra- and intersubunit Lys-Lys crosslinks in trypsinized samples of purified monomeric and oligomeric protein bands from SDS-polyacrylamide gels may be identified and differentiated by MALDI-TOF MS studies of limited resolution. Thus, broadly available MS platforms are capable of providing distance constraints that may be utilized in characterizing large complexes that may be less amenable to NMR and crystallographic studies. Systematic studies of state-dependent chemical crosslinking and mass spectrometric identification of crosslinked sites has the potential to complement computational modeling efforts by providing constraints that can validate and refine allosteric models. PMID:25025226

  10. Incorporation of physical constraints in optimal surface search for renal cortex segmentation

    NASA Astrophysics Data System (ADS)

    Li, Xiuli; Chen, Xinjian; Yao, Jianhua; Zhang, Xing; Tian, Jie

    2012-02-01

    In this paper, we propose a novel approach for multiple surfaces segmentation based on the incorporation of physical constraints in optimal surface searching. We apply our new approach to solve the renal cortex segmentation problem, an important but not sufficiently researched issue. In this study, in order to better restrain the intensity proximity of the renal cortex and renal column, we extend the optimal surface search approach to allow for varying sampling distance and physical separation constraints, instead of the traditional fixed sampling distance and numerical separation constraints. The sampling distance of each vertex-column is computed according to the sparsity of the local triangular mesh. Then the physical constraint learned from a priori renal cortex thickness is applied to the inter-surface arcs as the separation constraints. Appropriate varying sampling distance and separation constraints were learnt from 6 clinical CT images. After training, the proposed approach was tested on a test set of 10 images. The manual segmentation of renal cortex was used as the reference standard. Quantitative analysis of the segmented renal cortex indicates that overall segmentation accuracy was increased after introducing the varying sampling distance and physical separation constraints (the average true positive volume fraction (TPVF) and false positive volume fraction (FPVF) were 83.96% and 2.80%, respectively, by using varying sampling distance and physical separation constraints compared to 74.10% and 0.18%, respectively, by using fixed sampling distance and numerical separation constraints). The experimental results demonstrated the effectiveness of the proposed approach.

  11. Solving protein structures using short-distance cross-linking constraints as a guide for discrete molecular dynamics simulations

    PubMed Central

    Brodie, Nicholas I.; Popov, Konstantin I.; Petrotchenko, Evgeniy V.; Dokholyan, Nikolay V.; Borchers, Christoph H.

    2017-01-01

    We present an integrated experimental and computational approach for de novo protein structure determination in which short-distance cross-linking data are incorporated into rapid discrete molecular dynamics (DMD) simulations as constraints, reducing the conformational space and achieving the correct protein folding on practical time scales. We tested our approach on myoglobin and FK506 binding protein—models for α helix–rich and β sheet–rich proteins, respectively—and found that the lowest-energy structures obtained were in agreement with the crystal structure, hydrogen-deuterium exchange, surface modification, and long-distance cross-linking validation data. Our approach is readily applicable to other proteins with unknown structures. PMID:28695211

  12. Solving protein structures using short-distance cross-linking constraints as a guide for discrete molecular dynamics simulations.

    PubMed

    Brodie, Nicholas I; Popov, Konstantin I; Petrotchenko, Evgeniy V; Dokholyan, Nikolay V; Borchers, Christoph H

    2017-07-01

    We present an integrated experimental and computational approach for de novo protein structure determination in which short-distance cross-linking data are incorporated into rapid discrete molecular dynamics (DMD) simulations as constraints, reducing the conformational space and achieving the correct protein folding on practical time scales. We tested our approach on myoglobin and FK506 binding protein-models for α helix-rich and β sheet-rich proteins, respectively-and found that the lowest-energy structures obtained were in agreement with the crystal structure, hydrogen-deuterium exchange, surface modification, and long-distance cross-linking validation data. Our approach is readily applicable to other proteins with unknown structures.

  13. Non-iterative distance constraints enforcement for cloth drapes simulation

    NASA Astrophysics Data System (ADS)

    Hidajat, R. L. L. G.; Wibowo, Arifin, Z.; Suyitno

    2016-03-01

    A cloth simulation represents the behavior of cloth objects such as flag, tablecloth, or even garments has application in clothing animation for games and virtual shops. Elastically deformable models have widely used to provide realistic and efficient simulation, however problem of overstretching is encountered. We introduce a new cloth simulation algorithm that replaces iterative distance constraint enforcement steps with non-iterative ones for preventing over stretching in a spring-mass system for cloth modeling. Our method is based on a simple position correction procedure applied at one end of a spring. In our experiments, we developed a rectangle cloth model which is initially at a horizontal position with one point is fixed, and it is allowed to drape by its own weight. Our simulation is able to achieve a plausible cloth drapes as in reality. This paper aims to demonstrate the reliability of our approach to overcome overstretches while decreasing the computational cost of the constraint enforcement process due to an iterative procedure that is eliminated.

  14. Consistency among distance measurements: transparency, BAO scale and accelerated expansion

    NASA Astrophysics Data System (ADS)

    Avgoustidis, Anastasios; Verde, Licia; Jimenez, Raul

    2009-06-01

    We explore consistency among different distance measures, including Supernovae Type Ia data, measurements of the Hubble parameter, and determination of the Baryon acoustic oscillation scale. We present new constraints on the cosmic transparency combining H(z) data together with the latest Supernovae Type Ia data compilation. This combination, in the context of a flat ΛCDM model, improves current constraints by nearly an order of magnitude although the constraints presented here are parametric rather than non-parametric. We re-examine the recently reported tension between the Baryon acoustic oscillation scale and Supernovae data in light of possible deviations from transparency, concluding that the source of the discrepancy may most likely be found among systematic effects of the modelling of the low redshift data or a simple ~ 2-σ statistical fluke, rather than in exotic physics. Finally, we attempt to draw model-independent conclusions about the recent accelerated expansion, determining the acceleration redshift to be zacc = 0.35+0.20-0.13 (1-σ).

  15. A theoretical perspective on the accuracy of rotational resonance (R 2)-based distance measurements in solid-state NMR

    NASA Astrophysics Data System (ADS)

    Pandey, Manoj Kumar; Ramachandran, Ramesh

    2010-03-01

    The application of solid-state NMR methodology for bio-molecular structure determination requires the measurement of constraints in the form of 13C-13C and 13C-15N distances, torsion angles and, in some cases, correlation of the anisotropic interactions. Since the availability of structurally important constraints in the solid state is limited due to lack of sufficient spectral resolution, the accuracy of the measured constraints become vital in studies relating the three-dimensional structure of proteins to its biological functions. Consequently, the theoretical methods employed to quantify the experimental data become important. To accentuate this aspect, we re-examine analytical two-spin models currently employed in the estimation of 13C-13C distances based on the rotational resonance (R 2) phenomenon. Although the error bars for the estimated distances tend to be in the range 0.5-1.0 Å, R 2 experiments are routinely employed in a variety of systems ranging from simple peptides to more complex amyloidogenic proteins. In this article we address this aspect by highlighting the systematic errors introduced by analytical models employing phenomenological damping terms to describe multi-spin effects. Specifically, the spin dynamics in R 2 experiments is described using Floquet theory employing two different operator formalisms. The systematic errors introduced by the phenomenological damping terms and their limitations are elucidated in two analytical models and analysed by comparing the results with rigorous numerical simulations.

  16. Testing for Lorentz violation: constraints on standard-model-extension parameters via lunar laser ranging.

    PubMed

    Battat, James B R; Chandler, John F; Stubbs, Christopher W

    2007-12-14

    We present constraints on violations of Lorentz invariance based on archival lunar laser-ranging (LLR) data. LLR measures the Earth-Moon separation by timing the round-trip travel of light between the two bodies and is currently accurate to the equivalent of a few centimeters (parts in 10(11) of the total distance). By analyzing this LLR data under the standard-model extension (SME) framework, we derived six observational constraints on dimensionless SME parameters that describe potential Lorentz violation. We found no evidence for Lorentz violation at the 10(-6) to 10(-11) level in these parameters. This work constitutes the first LLR constraints on SME parameters.

  17. Capacitated set-covering model considering the distance objective and dependency of alternative facilities

    NASA Astrophysics Data System (ADS)

    Wayan Suletra, I.; Priyandari, Yusuf; Jauhari, Wakhid A.

    2018-03-01

    We propose a new model of facility location to solve a kind of problem that belong to a class of set-covering problem using an integer programming formulation. Our model contains a single objective function, but it represents two goals. The first is to minimize the number of facilities, and the other is to minimize the total distance of customers to facilities. The first goal is a mandatory goal, and the second is an improvement goal that is very useful when alternate optimum solutions for the first goal exist. We use a big number as a weight on the first goal to force the solution algorithm to give first priority to the first goal. Besides considering capacity constraints, our model accommodates a kind of either-or constraints representing facilities dependency. The either-or constraints will prevent the solution algorithm to select two or more facilities from the same set of facility with mutually exclusive properties. A real location selection problem to locate a set of wastewater treatment facility (IPAL) in Surakarta city, Indonesia, will describe the implementation of our model. A numerical example is given using the data of that real problem.

  18. On the Miller-Tucker-Zemlin Based Formulations for the Distance Constrained Vehicle Routing Problems

    NASA Astrophysics Data System (ADS)

    Kara, Imdat

    2010-11-01

    Vehicle Routing Problem (VRP), is an extension of the well known Traveling Salesman Problem (TSP) and has many practical applications in the fields of distribution and logistics. When the VRP consists of distance based constraints it is called Distance Constrained Vehicle Routing Problem (DVRP). However, the literature addressing on the DVRP is scarce. In this paper, existing two-indexed integer programming formulations, having Miller-Tucker-Zemlin based subtour elimination constraints, are reviewed. Existing formulations are simplified and obtained formulation is presented as formulation F1. It is shown that, the distance bounding constraints of the formulation F1, may not generate the distance traveled up to the related node. To do this, we redefine the auxiliary variables of the formulation and propose second formulation F2 with new and easy to use distance bounding constraints. Adaptation of the second formulation to the cases where new restrictions such as minimal distance traveled by each vehicle or other objectives such as minimizing the longest distance traveled is discussed.

  19. Properties of a new small-world network with spatially biased random shortcuts

    NASA Astrophysics Data System (ADS)

    Matsuzawa, Ryo; Tanimoto, Jun; Fukuda, Eriko

    2017-11-01

    This paper introduces a small-world (SW) network with a power-law distance distribution that differs from conventional models in that it uses completely random shortcuts. By incorporating spatial constraints, we analyze the divergence of the proposed model from conventional models in terms of fundamental network properties such as clustering coefficient, average path length, and degree distribution. We find that when the spatial constraint more strongly prohibits a long shortcut, the clustering coefficient is improved and the average path length increases. We also analyze the spatial prisoner's dilemma (SPD) games played on our new SW network in order to understand its dynamical characteristics. Depending on the basis graph, i.e., whether it is a one-dimensional ring or a two-dimensional lattice, and the parameter controlling the prohibition of long-distance shortcuts, the emergent results can vastly differ.

  20. A novel artificial immune algorithm for spatial clustering with obstacle constraint and its applications.

    PubMed

    Sun, Liping; Luo, Yonglong; Ding, Xintao; Zhang, Ji

    2014-01-01

    An important component of a spatial clustering algorithm is the distance measure between sample points in object space. In this paper, the traditional Euclidean distance measure is replaced with innovative obstacle distance measure for spatial clustering under obstacle constraints. Firstly, we present a path searching algorithm to approximate the obstacle distance between two points for dealing with obstacles and facilitators. Taking obstacle distance as similarity metric, we subsequently propose the artificial immune clustering with obstacle entity (AICOE) algorithm for clustering spatial point data in the presence of obstacles and facilitators. Finally, the paper presents a comparative analysis of AICOE algorithm and the classical clustering algorithms. Our clustering model based on artificial immune system is also applied to the case of public facility location problem in order to establish the practical applicability of our approach. By using the clone selection principle and updating the cluster centers based on the elite antibodies, the AICOE algorithm is able to achieve the global optimum and better clustering effect.

  1. Approximate Bayesian computation in large-scale structure: constraining the galaxy-halo connection

    NASA Astrophysics Data System (ADS)

    Hahn, ChangHoon; Vakili, Mohammadjavad; Walsh, Kilian; Hearin, Andrew P.; Hogg, David W.; Campbell, Duncan

    2017-08-01

    Standard approaches to Bayesian parameter inference in large-scale structure assume a Gaussian functional form (chi-squared form) for the likelihood. This assumption, in detail, cannot be correct. Likelihood free inferences such as approximate Bayesian computation (ABC) relax these restrictions and make inference possible without making any assumptions on the likelihood. Instead ABC relies on a forward generative model of the data and a metric for measuring the distance between the model and data. In this work, we demonstrate that ABC is feasible for LSS parameter inference by using it to constrain parameters of the halo occupation distribution (HOD) model for populating dark matter haloes with galaxies. Using specific implementation of ABC supplemented with population Monte Carlo importance sampling, a generative forward model using HOD and a distance metric based on galaxy number density, two-point correlation function and galaxy group multiplicity function, we constrain the HOD parameters of mock observation generated from selected 'true' HOD parameters. The parameter constraints we obtain from ABC are consistent with the 'true' HOD parameters, demonstrating that ABC can be reliably used for parameter inference in LSS. Furthermore, we compare our ABC constraints to constraints we obtain using a pseudo-likelihood function of Gaussian form with MCMC and find consistent HOD parameter constraints. Ultimately, our results suggest that ABC can and should be applied in parameter inference for LSS analyses.

  2. Representational Distance Learning for Deep Neural Networks

    PubMed Central

    McClure, Patrick; Kriegeskorte, Nikolaus

    2016-01-01

    Deep neural networks (DNNs) provide useful models of visual representational transformations. We present a method that enables a DNN (student) to learn from the internal representational spaces of a reference model (teacher), which could be another DNN or, in the future, a biological brain. Representational spaces of the student and the teacher are characterized by representational distance matrices (RDMs). We propose representational distance learning (RDL), a stochastic gradient descent method that drives the RDMs of the student to approximate the RDMs of the teacher. We demonstrate that RDL is competitive with other transfer learning techniques for two publicly available benchmark computer vision datasets (MNIST and CIFAR-100), while allowing for architectural differences between student and teacher. By pulling the student's RDMs toward those of the teacher, RDL significantly improved visual classification performance when compared to baseline networks that did not use transfer learning. In the future, RDL may enable combined supervised training of deep neural networks using task constraints (e.g., images and category labels) and constraints from brain-activity measurements, so as to build models that replicate the internal representational spaces of biological brains. PMID:28082889

  3. Representational Distance Learning for Deep Neural Networks.

    PubMed

    McClure, Patrick; Kriegeskorte, Nikolaus

    2016-01-01

    Deep neural networks (DNNs) provide useful models of visual representational transformations. We present a method that enables a DNN (student) to learn from the internal representational spaces of a reference model (teacher), which could be another DNN or, in the future, a biological brain. Representational spaces of the student and the teacher are characterized by representational distance matrices (RDMs). We propose representational distance learning (RDL), a stochastic gradient descent method that drives the RDMs of the student to approximate the RDMs of the teacher. We demonstrate that RDL is competitive with other transfer learning techniques for two publicly available benchmark computer vision datasets (MNIST and CIFAR-100), while allowing for architectural differences between student and teacher. By pulling the student's RDMs toward those of the teacher, RDL significantly improved visual classification performance when compared to baseline networks that did not use transfer learning. In the future, RDL may enable combined supervised training of deep neural networks using task constraints (e.g., images and category labels) and constraints from brain-activity measurements, so as to build models that replicate the internal representational spaces of biological brains.

  4. Estimating rupture distances without a rupture

    USGS Publications Warehouse

    Thompson, Eric M.; Worden, Charles

    2017-01-01

    Most ground motion prediction equations (GMPEs) require distances that are defined relative to a rupture model, such as the distance to the surface projection of the rupture (RJB) or the closest distance to the rupture plane (RRUP). There are a number of situations in which GMPEs are used where it is either necessary or advantageous to derive rupture distances from point-source distance metrics, such as hypocentral (RHYP) or epicentral (REPI) distance. For ShakeMap, it is necessary to provide an estimate of the shaking levels for events without rupture models, and before rupture models are available for events that eventually do have rupture models. In probabilistic seismic hazard analysis, it is often convenient to use point-source distances for gridded seismicity sources, particularly if a preferred orientation is unknown. This avoids the computationally cumbersome task of computing rupture-based distances for virtual rupture planes across all strikes and dips for each source. We derive average rupture distances conditioned on REPI, magnitude, and (optionally) back azimuth, for a variety of assumed seismological constraints. Additionally, we derive adjustment factors for GMPE standard deviations that reflect the added uncertainty in the ground motion estimation when point-source distances are used to estimate rupture distances.

  5. Cross-layer Energy Optimization Under Image Quality Constraints for Wireless Image Transmissions.

    PubMed

    Yang, Na; Demirkol, Ilker; Heinzelman, Wendi

    2012-01-01

    Wireless image transmission is critical in many applications, such as surveillance and environment monitoring. In order to make the best use of the limited energy of the battery-operated cameras, while satisfying the application-level image quality constraints, cross-layer design is critical. In this paper, we develop an image transmission model that allows the application layer (e.g., the user) to specify an image quality constraint, and optimizes the lower layer parameters of transmit power and packet length, to minimize the energy dissipation in image transmission over a given distance. The effectiveness of this approach is evaluated by applying the proposed energy optimization to a reference ZigBee system and a WiFi system, and also by comparing to an energy optimization study that does not consider any image quality constraint. Evaluations show that our scheme outperforms the default settings of the investigated commercial devices and saves a significant amount of energy at middle-to-large transmission distances.

  6. The importance of topography-controlled sub-grid process heterogeneity and semi-quantitative prior constraints in distributed hydrological models

    NASA Astrophysics Data System (ADS)

    Nijzink, Remko C.; Samaniego, Luis; Mai, Juliane; Kumar, Rohini; Thober, Stephan; Zink, Matthias; Schäfer, David; Savenije, Hubert H. G.; Hrachowitz, Markus

    2016-03-01

    Heterogeneity of landscape features like terrain, soil, and vegetation properties affects the partitioning of water and energy. However, it remains unclear to what extent an explicit representation of this heterogeneity at the sub-grid scale of distributed hydrological models can improve the hydrological consistency and the robustness of such models. In this study, hydrological process complexity arising from sub-grid topography heterogeneity was incorporated into the distributed mesoscale Hydrologic Model (mHM). Seven study catchments across Europe were used to test whether (1) the incorporation of additional sub-grid variability on the basis of landscape-derived response units improves model internal dynamics, (2) the application of semi-quantitative, expert-knowledge-based model constraints reduces model uncertainty, and whether (3) the combined use of sub-grid response units and model constraints improves the spatial transferability of the model. Unconstrained and constrained versions of both the original mHM and mHMtopo, which allows for topography-based sub-grid heterogeneity, were calibrated for each catchment individually following a multi-objective calibration strategy. In addition, four of the study catchments were simultaneously calibrated and their feasible parameter sets were transferred to the remaining three receiver catchments. In a post-calibration evaluation procedure the probabilities of model and transferability improvement, when accounting for sub-grid variability and/or applying expert-knowledge-based model constraints, were assessed on the basis of a set of hydrological signatures. In terms of the Euclidian distance to the optimal model, used as an overall measure of model performance with respect to the individual signatures, the model improvement achieved by introducing sub-grid heterogeneity to mHM in mHMtopo was on average 13 %. The addition of semi-quantitative constraints to mHM and mHMtopo resulted in improvements of 13 and 19 %, respectively, compared to the base case of the unconstrained mHM. Most significant improvements in signature representations were, in particular, achieved for low flow statistics. The application of prior semi-quantitative constraints further improved the partitioning between runoff and evaporative fluxes. In addition, it was shown that suitable semi-quantitative prior constraints in combination with the transfer-function-based regularization approach of mHM can be beneficial for spatial model transferability as the Euclidian distances for the signatures improved on average by 2 %. The effect of semi-quantitative prior constraints combined with topography-guided sub-grid heterogeneity on transferability showed a more variable picture of improvements and deteriorations, but most improvements were observed for low flow statistics.

  7. Study of the Navigation Method for a Snake Robot Based on the Kinematics Model with MEMS IMU.

    PubMed

    Zhao, Xu; Dou, Lihua; Su, Zhong; Liu, Ning

    2018-03-16

    A snake robot is a type of highly redundant mobile robot that significantly differs from a tracked robot, wheeled robot and legged robot. To address the issue of a snake robot performing self-localization in the application environment without assistant orientation, an autonomous navigation method is proposed based on the snake robot's motion characteristic constraints. The method realized the autonomous navigation of the snake robot with non-nodes and an external assistant using its own Micro-Electromechanical-Systems (MEMS) Inertial-Measurement-Unit (IMU). First, it studies the snake robot's motion characteristics, builds the kinematics model, and then analyses the motion constraint characteristics and motion error propagation properties. Second, it explores the snake robot's navigation layout, proposes a constraint criterion and the fixed relationship, and makes zero-state constraints based on the motion features and control modes of a snake robot. Finally, it realizes autonomous navigation positioning based on the Extended-Kalman-Filter (EKF) position estimation method under the constraints of its motion characteristics. With the self-developed snake robot, the test verifies the proposed method, and the position error is less than 5% of Total-Traveled-Distance (TDD). In a short-distance environment, this method is able to meet the requirements of a snake robot in order to perform autonomous navigation and positioning in traditional applications and can be extended to other familiar multi-link robots.

  8. Real-time inextensible surgical thread simulation.

    PubMed

    Xu, Lang; Liu, Qian

    2018-03-27

    This paper discusses a real-time simulation method of inextensible surgical thread based on the Cosserat rod theory using position-based dynamics (PBD). The method realizes stable twining and knotting of surgical thread while including inextensibility, bending, twisting and coupling effects. The Cosserat rod theory is used to model the nonlinear elastic behavior of surgical thread. The surgical thread model is solved with PBD to achieve a real-time, extremely stable simulation. Due to the one-dimensional linear structure of surgical thread, the direct solution of the distance constraint based on tridiagonal matrix algorithm is used to enhance stretching resistance in every constraint projection iteration. In addition, continuous collision detection and collision response guarantee a large time step and high performance. Furthermore, friction is integrated into the constraint projection process to stabilize the twining of multiple threads and complex contact situations. Through comparisons with existing methods, the surgical thread maintains constant length under large deformation after applying the direct distance constraint in our method. The twining and knotting of multiple threads correspond to stable solutions to contact and friction forces. A surgical suture scene is also modeled to demonstrate the practicality and simplicity of our method. Our method achieves stable and fast simulation of inextensible surgical thread. Benefiting from the unified particle framework, the rigid body, elastic rod, and soft body can be simultaneously simulated. The method is appropriate for applications in virtual surgery that require multiple dynamic bodies.

  9. Energetic and biomechanical constraints on animal migration distance.

    PubMed

    Hein, Andrew M; Hou, Chen; Gillooly, James F

    2012-02-01

    Animal migration is one of the great wonders of nature, but the factors that determine how far migrants travel remain poorly understood. We present a new quantitative model of animal migration and use it to describe the maximum migration distance of walking, swimming and flying migrants. The model combines biomechanics and metabolic scaling to show how maximum migration distance is constrained by body size for each mode of travel. The model also indicates that the number of body lengths travelled by walking and swimming migrants should be approximately invariant of body size. Data from over 200 species of migratory birds, mammals, fish, and invertebrates support the central conclusion of the model - that body size drives variation in maximum migration distance among species through its effects on metabolism and the cost of locomotion. The model provides a new tool to enhance general understanding of the ecology and evolution of migration. © 2011 Blackwell Publishing Ltd/CNRS.

  10. The importance of topography controlled sub-grid process heterogeneity in distributed hydrological models

    NASA Astrophysics Data System (ADS)

    Nijzink, R. C.; Samaniego, L.; Mai, J.; Kumar, R.; Thober, S.; Zink, M.; Schäfer, D.; Savenije, H. H. G.; Hrachowitz, M.

    2015-12-01

    Heterogeneity of landscape features like terrain, soil, and vegetation properties affect the partitioning of water and energy. However, it remains unclear to which extent an explicit representation of this heterogeneity at the sub-grid scale of distributed hydrological models can improve the hydrological consistency and the robustness of such models. In this study, hydrological process complexity arising from sub-grid topography heterogeneity was incorporated in the distributed mesoscale Hydrologic Model (mHM). Seven study catchments across Europe were used to test whether (1) the incorporation of additional sub-grid variability on the basis of landscape-derived response units improves model internal dynamics, (2) the application of semi-quantitative, expert-knowledge based model constraints reduces model uncertainty; and (3) the combined use of sub-grid response units and model constraints improves the spatial transferability of the model. Unconstrained and constrained versions of both, the original mHM and mHMtopo, which allows for topography-based sub-grid heterogeneity, were calibrated for each catchment individually following a multi-objective calibration strategy. In addition, four of the study catchments were simultaneously calibrated and their feasible parameter sets were transferred to the remaining three receiver catchments. In a post-calibration evaluation procedure the probabilities of model and transferability improvement, when accounting for sub-grid variability and/or applying expert-knowledge based model constraints, were assessed on the basis of a set of hydrological signatures. In terms of the Euclidian distance to the optimal model, used as overall measure for model performance with respect to the individual signatures, the model improvement achieved by introducing sub-grid heterogeneity to mHM in mHMtopo was on average 13 %. The addition of semi-quantitative constraints to mHM and mHMtopo resulted in improvements of 13 and 19 % respectively, compared to the base case of the unconstrained mHM. Most significant improvements in signature representations were, in particular, achieved for low flow statistics. The application of prior semi-quantitative constraints further improved the partitioning between runoff and evaporative fluxes. Besides, it was shown that suitable semi-quantitative prior constraints in combination with the transfer function based regularization approach of mHM, can be beneficial for spatial model transferability as the Euclidian distances for the signatures improved on average by 2 %. The effect of semi-quantitative prior constraints combined with topography-guided sub-grid heterogeneity on transferability showed a more variable picture of improvements and deteriorations, but most improvements were observed for low flow statistics.

  11. A Selfish Constraint Satisfaction Genetic Algorithms for Planning a Long-Distance Transportation Network

    NASA Astrophysics Data System (ADS)

    Onoyama, Takashi; Maekawa, Takuya; Kubota, Sen; Tsuruta, Setuso; Komoda, Norihisa

    To build a cooperative logistics network covering multiple enterprises, a planning method that can build a long-distance transportation network is required. Many strict constraints are imposed on this type of problem. To solve these strict-constraint problems, a selfish constraint satisfaction genetic algorithm (GA) is proposed. In this GA, each gene of an individual satisfies only its constraint selfishly, disregarding the constraints of other genes in the same individuals. Moreover, a constraint pre-checking method is also applied to improve the GA convergence speed. The experimental result shows the proposed method can obtain an accurate solution in a practical response time.

  12. Distance and slope constraints: adaptation and variability in golf putting.

    PubMed

    Dias, Gonçalo; Couceiro, Micael S; Barreiros, João; Clemente, Filipe M; Mendes, Rui; Martins, Fernando M

    2014-07-01

    The main objective of this study is to understand the adaptation to external constraints and the effects of variability in a golf putting task. We describe the adaptation of relevant variables of golf putting to the distance to the hole and to the addition of a slope. The sample consisted of 10 adult male (33.80 ± 11.89 years), volunteers, right handed and highly skilled golfers with an average handicap of 10.82. Each player performed 30 putts at distances of 2, 3 and 4 meters (90 trials in Condition 1). The participants also performed 90 trials, at the same distances, with a constraint imposed by a slope (Condition 2). The results indicate that the players change some parameters to adjust to the task constraints, namely the duration of the backswing phase, the speed of the club head and the acceleration at the moment of impact with the ball. The effects of different golf putting distances in the no-slope condition on different kinematic variables suggest a linear adjustment to distance variation that was not observed when in the slope condition.

  13. Structural and functional properties of spatially embedded scale-free networks.

    PubMed

    Emmerich, Thorsten; Bunde, Armin; Havlin, Shlomo

    2014-06-01

    Scale-free networks have been studied mostly as non-spatially embedded systems. However, in many realistic cases, they are spatially embedded and these constraints should be considered. Here, we study the structural and functional properties of a model of scale-free (SF) spatially embedded networks. In our model, both the degree and the length of links follow power law distributions as found in many real networks. We show that not all SF networks can be embedded in space and that the largest degree of a node in the network is usually smaller than in nonembedded SF networks. Moreover, the spatial constraints (each node has only few neighboring nodes) introduce degree-degree anticorrelations (disassortativity) since two high degree nodes cannot stay close in space. We also find significant effects of space embedding on the hopping distances (chemical distance) and the vulnerability of the networks.

  14. Study of the Navigation Method for a Snake Robot Based on the Kinematics Model with MEMS IMU

    PubMed Central

    Dou, Lihua; Su, Zhong; Liu, Ning

    2018-01-01

    A snake robot is a type of highly redundant mobile robot that significantly differs from a tracked robot, wheeled robot and legged robot. To address the issue of a snake robot performing self-localization in the application environment without assistant orientation, an autonomous navigation method is proposed based on the snake robot’s motion characteristic constraints. The method realized the autonomous navigation of the snake robot with non-nodes and an external assistant using its own Micro-Electromechanical-Systems (MEMS) Inertial-Measurement-Unit (IMU). First, it studies the snake robot’s motion characteristics, builds the kinematics model, and then analyses the motion constraint characteristics and motion error propagation properties. Second, it explores the snake robot’s navigation layout, proposes a constraint criterion and the fixed relationship, and makes zero-state constraints based on the motion features and control modes of a snake robot. Finally, it realizes autonomous navigation positioning based on the Extended-Kalman-Filter (EKF) position estimation method under the constraints of its motion characteristics. With the self-developed snake robot, the test verifies the proposed method, and the position error is less than 5% of Total-Traveled-Distance (TDD). In a short-distance environment, this method is able to meet the requirements of a snake robot in order to perform autonomous navigation and positioning in traditional applications and can be extended to other familiar multi-link robots. PMID:29547515

  15. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Guo, Yiting; Dong, Bin; Wang, Bing

    Purpose: Effective and accurate segmentation of the aortic valve (AV) from sequenced ultrasound (US) images remains a technical challenge because of intrinsic factors of ultrasound images that impact the quality and the continuous changes of shape and position of segmented objects. In this paper, a novel shape-constraint gradient Chan-Vese (GCV) model is proposed for segmenting the AV from time serial echocardiography. Methods: The GCV model is derived by incorporating the energy of the gradient vector flow into a CV model framework, where the gradient vector energy term is introduced by calculating the deviation angle between the inward normal force ofmore » the evolution contour and the gradient vector force. The flow force enlarges the capture range and enhances the blurred boundaries of objects. This is achieved by adding a circle-like contour (constructed using the AV structure region as a constraint shape) as an energy item to the GCV model through the shape comparison function. This shape-constrained energy can enhance the image constraint force by effectively connecting separate gaps of the object edge as well as driving the evolution contour to quickly approach the ideal object. Because of the slight movement of the AV in adjacent frames, the initial constraint shape is defined by users, with the other constraint shapes being derived from the segmentation results of adjacent sequence frames after morphological filtering. The AV is segmented from the US images by minimizing the proposed energy function. Results: To evaluate the performance of the proposed method, five assessment parameters were used to compare it with manual delineations performed by radiologists (gold standards). Three hundred and fifteen images acquired from nine groups were analyzed in the experiment. The area-metric overlap error rate was 6.89% ± 2.88%, the relative area difference rate 3.94% ± 2.63%, the average symmetric contour distance 1.08 ± 0.43 mm, the root mean square symmetric contour distance 1.37 ± 0.52 mm, and the maximum symmetric contour distance was 3.57 ± 1.72 mm. Conclusions: Compared with the CV model, as a result of the combination of the gradient vector and neighborhood shape information, this semiautomatic segmentation method significantly improves the accuracy and robustness of AV segmentation, making it feasible for improved segmentation of aortic valves from US images that have fuzzy boundaries.« less

  16. Emerging spatial curvature can resolve the tension between high-redshift CMB and low-redshift distance ladder measurements of the Hubble constant

    NASA Astrophysics Data System (ADS)

    Bolejko, Krzysztof

    2018-05-01

    The measurements of the Hubble constant reveal a tension between high-redshift (CMB) and low-redshift (distance ladder) constraints. So far neither observational systematics nor new physics has been successfully implemented to explain away this tension. This paper presents a new solution to the Hubble constant problem. The solution is based on the Simsilun simulation (relativistic simulation of the large scale structure of the Universe) with the ray-tracing algorithm implemented. The initial conditions for the Simsilun simulation were set up as perturbations around the Λ CDM model. However, unlike in the standard cosmological model (i.e., Λ CDM model +perturbations ), within the Simsilun simulation relativistic and nonlinear evolution of cosmic structures lead to the phenomenon of emerging spatial curvature, where the mean spatial curvature evolves from the spatial flatness of the early Universe towards the slightly curved present-day Universe. Consequently, the present-day expansion rate is slightly faster compared to the spatially flat Λ CDM model. The results of the ray-tracing analysis show that the Universe which starts with initial conditions consistent with the Planck constraints should have the Hubble constant H0=72.5 ±2.1 km s-1 Mpc-1 . When the Simsilun simulation was rerun with no inhomogeneities imposed, the Hubble constant inferred within such a homogeneous simulation was H0=68.1 ±2.0 km s-1 Mpc-1 . Thus, the inclusion of nonlinear relativistic evolution that leads to the emergence of the spatial curvature can explain why the low-redshift measurements favor higher values compared to the high-redshift constraints and alleviate the tension between the CMB and distance ladder measurements of the Hubble constant.

  17. GNSS Precise Kinematic Positioning for Multiple Kinematic Stations Based on A Priori Distance Constraints

    PubMed Central

    He, Kaifei; Xu, Tianhe; Förste, Christoph; Petrovic, Svetozar; Barthelmes, Franz; Jiang, Nan; Flechtner, Frank

    2016-01-01

    When applying the Global Navigation Satellite System (GNSS) for precise kinematic positioning in airborne and shipborne gravimetry, multiple GNSS receiving equipment is often fixed mounted on the kinematic platform carrying the gravimetry instrumentation. Thus, the distances among these GNSS antennas are known and invariant. This information can be used to improve the accuracy and reliability of the state estimates. For this purpose, the known distances between the antennas are applied as a priori constraints within the state parameters adjustment. These constraints are introduced in such a way that their accuracy is taken into account. To test this approach, GNSS data of a Baltic Sea shipborne gravimetric campaign have been used. The results of our study show that an application of distance constraints improves the accuracy of the GNSS kinematic positioning, for example, by about 4 mm for the radial component. PMID:27043580

  18. GNSS Precise Kinematic Positioning for Multiple Kinematic Stations Based on A Priori Distance Constraints.

    PubMed

    He, Kaifei; Xu, Tianhe; Förste, Christoph; Petrovic, Svetozar; Barthelmes, Franz; Jiang, Nan; Flechtner, Frank

    2016-04-01

    When applying the Global Navigation Satellite System (GNSS) for precise kinematic positioning in airborne and shipborne gravimetry, multiple GNSS receiving equipment is often fixed mounted on the kinematic platform carrying the gravimetry instrumentation. Thus, the distances among these GNSS antennas are known and invariant. This information can be used to improve the accuracy and reliability of the state estimates. For this purpose, the known distances between the antennas are applied as a priori constraints within the state parameters adjustment. These constraints are introduced in such a way that their accuracy is taken into account. To test this approach, GNSS data of a Baltic Sea shipborne gravimetric campaign have been used. The results of our study show that an application of distance constraints improves the accuracy of the GNSS kinematic positioning, for example, by about 4 mm for the radial component.

  19. Feasibility of employing model-based optimization of pulse amplitude and electrode distance for effective tumor electropermeabilization.

    PubMed

    Sel, Davorka; Lebar, Alenka Macek; Miklavcic, Damijan

    2007-05-01

    In electrochemotherapy (ECT) electropermeabilization, parameters (pulse amplitude, electrode setup) need to be customized in order to expose the whole tumor to electric field intensities above permeabilizing threshold to achieve effective ECT. In this paper, we present a model-based optimization approach toward determination of optimal electropermeabilization parameters for effective ECT. The optimization is carried out by minimizing the difference between the permeabilization threshold and electric field intensities computed by finite element model in selected points of tumor. We examined the feasibility of model-based optimization of electropermeabilization parameters on a model geometry generated from computer tomography images, representing brain tissue with tumor. Continuous parameter subject to optimization was pulse amplitude. The distance between electrode pairs was optimized as a discrete parameter. Optimization also considered the pulse generator constraints on voltage and current. During optimization the two constraints were reached preventing the exposure of the entire volume of the tumor to electric field intensities above permeabilizing threshold. However, despite the fact that with the particular needle array holder and pulse generator the entire volume of the tumor was not permeabilized, the maximal extent of permeabilization for the particular case (electrodes, tissue) was determined with the proposed approach. Model-based optimization approach could also be used for electro-gene transfer, where electric field intensities should be distributed between permeabilizing threshold and irreversible threshold-the latter causing tissue necrosis. This can be obtained by adding constraints on maximum electric field intensity in optimization procedure.

  20. Hybrid services efficient provisioning over the network coding-enabled elastic optical networks

    NASA Astrophysics Data System (ADS)

    Wang, Xin; Gu, Rentao; Ji, Yuefeng; Kavehrad, Mohsen

    2017-03-01

    As a variety of services have emerged, hybrid services have become more common in real optical networks. Although the elastic spectrum resource optimizations over the elastic optical networks (EONs) have been widely investigated, little research has been carried out on the hybrid services of the routing and spectrum allocation (RSA), especially over the network coding-enabled EON. We investigated the RSA for the unicast service and network coding-based multicast service over the network coding-enabled EON with the constraints of time delay and transmission distance. To address this issue, a mathematical model was built to minimize the total spectrum consumption for the hybrid services over the network coding-enabled EON under the constraints of time delay and transmission distance. The model guarantees different routing constraints for different types of services. The immediate nodes over the network coding-enabled EON are assumed to be capable of encoding the flows for different kinds of information. We proposed an efficient heuristic algorithm of the network coding-based adaptive routing and layered graph-based spectrum allocation algorithm (NCAR-LGSA). From the simulation results, NCAR-LGSA shows highly efficient performances in terms of the spectrum resources utilization under different network scenarios compared with the benchmark algorithms.

  1. Investigating energy-based pool structure selection in the structure ensemble modeling with experimental distance constraints: The example from a multidomain protein Pub1.

    PubMed

    Zhu, Guanhua; Liu, Wei; Bao, Chenglong; Tong, Dudu; Ji, Hui; Shen, Zuowei; Yang, Daiwen; Lu, Lanyuan

    2018-05-01

    The structural variations of multidomain proteins with flexible parts mediate many biological processes, and a structure ensemble can be determined by selecting a weighted combination of representative structures from a simulated structure pool, producing the best fit to experimental constraints such as interatomic distance. In this study, a hybrid structure-based and physics-based atomistic force field with an efficient sampling strategy is adopted to simulate a model di-domain protein against experimental paramagnetic relaxation enhancement (PRE) data that correspond to distance constraints. The molecular dynamics simulations produce a wide range of conformations depicted on a protein energy landscape. Subsequently, a conformational ensemble recovered with low-energy structures and the minimum-size restraint is identified in good agreement with experimental PRE rates, and the result is also supported by chemical shift perturbations and small-angle X-ray scattering data. It is illustrated that the regularizations of energy and ensemble-size prevent an arbitrary interpretation of protein conformations. Moreover, energy is found to serve as a critical control to refine the structure pool and prevent data overfitting, because the absence of energy regularization exposes ensemble construction to the noise from high-energy structures and causes a more ambiguous representation of protein conformations. Finally, we perform structure-ensemble optimizations with a topology-based structure pool, to enhance the understanding on the ensemble results from different sources of pool candidates. © 2018 Wiley Periodicals, Inc.

  2. Astrophysical tests of modified gravity: Constraints from distance indicators in the nearby universe

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jain, Bhuvnesh; Vikram, Vinu; Sakstein, Jeremy

    2013-12-10

    We use distance measurements in the nearby universe to carry out new tests of gravity, surpassing other astrophysical tests by over two orders of magnitude for chameleon theories. The three nearby distance indicators—cepheids, tip of the red giant branch (TRGB) stars, and water masers—operate in gravitational fields of widely different strengths. This enables tests of scalar-tensor gravity theories because they are screened from enhanced forces to different extents. Inferred distances from cepheids and TRGB stars are altered (in opposite directions) over a range of chameleon gravity theory parameters well below the sensitivity of cosmological probes. Using published data, we havemore » compared cepheid and TRGB distances in a sample of unscreened dwarf galaxies within 10 Mpc. We use a comparable set of screened galaxies as a control sample. We find no evidence for the order unity force enhancements expected in these theories. Using a two-parameter description of the models (the coupling strength and background field value), we obtain constraints on both the chameleon and symmetron screening scenarios. In particular we show that f(R) models with background field values f {sub R0} above 5 × 10{sup –7} are ruled out at the 95% confidence level. We also compare TRGB and maser distances to the galaxy NGC 4258 as a second test for larger field values. While there are several approximations and caveats in our study, our analysis demonstrates the power of gravity tests in the local universe. We discuss the prospects for additional improved tests with future observations.« less

  3. Dependency distance: A new perspective on syntactic patterns in natural languages

    NASA Astrophysics Data System (ADS)

    Liu, Haitao; Xu, Chunshan; Liang, Junying

    2017-07-01

    Dependency distance, measured by the linear distance between two syntactically related words in a sentence, is generally held as an important index of memory burden and an indicator of syntactic difficulty. Since this constraint of memory is common for all human beings, there may well be a universal preference for dependency distance minimization (DDM) for the sake of reducing memory burden. This human-driven language universal is supported by big data analyses of various corpora that consistently report shorter overall dependency distance in natural languages than in artificial random languages and long-tailed distributions featuring a majority of short dependencies and a minority of long ones. Human languages, as complex systems, seem to have evolved to come up with diverse syntactic patterns under the universal pressure for dependency distance minimization. However, there always exist a small number of long-distance dependencies in natural languages, which may reflect some other biological or functional constraints. Language system may adapt itself to these sporadic long-distance dependencies. It is these universal constraints that have shaped such a rich diversity of syntactic patterns in human languages.

  4. Constraints on cosmological models and reconstructing the acceleration history of the Universe with gamma-ray burst distance indicators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liang Nan; Wu Puxun; Zhang Shuangnan

    2010-04-15

    Gamma-ray bursts (GRBs) have been regarded as standard candles at very high redshift for cosmology research. We have proposed a new method to calibrate GRB distance indicators with Type Ia supernova (SNe Ia) data in a completely cosmology-independent way to avoid the circularity problem that had limited the direct use of GRBs to probe cosmology [N. Liang, W. K. Xiao, Y. Liu, and S. N. Zhang, Astrophys. J. 685, 354 (2008).]. In this paper, a simple method is provided to combine GRB data into the joint observational data analysis to constrain cosmological models; in this method those SNe Ia datamore » points used for calibrating the GRB data are not used to avoid any correlation between them. We find that the {Lambda}CDM model is consistent with the joint data in the 1-{sigma} confidence region, using the GRB data at high redshift calibrated with the interpolating method, the Constitution set of SNe Ia, the cosmic microwave background radiation from Wilkinson Microwave Anisotropy Probe five year observation, the baryonic acoustic oscillation from the spectroscopic Sloan Digital Sky Survey Data Release 7 galaxy sample, the x-ray baryon mass fraction in clusters of galaxies, and the observational Hubble parameter versus redshift data. Comparing to the joint constraints with GRBs and without GRBs, we find that the contribution of GRBs to the joint cosmological constraints is a slight shift in the confidence regions of cosmological parameters to better enclose the {Lambda}CDM model. Finally, we reconstruct the acceleration history of the Universe up to z>6 with the distance moduli of SNe Ia and GRBs and find some features that deviate from the {Lambda}CDM model and seem to favor oscillatory cosmology models; however, further investigations are needed to better understand the situation.« less

  5. Rigid-Cluster Models of Conformational Transitions in Macromolecular Machines and Assemblies

    PubMed Central

    Kim, Moon K.; Jernigan, Robert L.; Chirikjian, Gregory S.

    2005-01-01

    We present a rigid-body-based technique (called rigid-cluster elastic network interpolation) to generate feasible transition pathways between two distinct conformations of a macromolecular assembly. Many biological molecules and assemblies consist of domains which act more or less as rigid bodies during large conformational changes. These collective motions are thought to be strongly related with the functions of a system. This fact encourages us to simply model a macromolecule or assembly as a set of rigid bodies which are interconnected with distance constraints. In previous articles, we developed coarse-grained elastic network interpolation (ENI) in which, for example, only Cα atoms are selected as representatives in each residue of a protein. We interpolate distance differences of two conformations in ENI by using a simple quadratic cost function, and the feasible conformations are generated without steric conflicts. Rigid-cluster interpolation is an extension of the ENI method with rigid-clusters replacing point masses. Now the intermediate conformations in an anharmonic pathway can be determined by the translational and rotational displacements of large clusters in such a way that distance constraints are observed. We present the derivation of the rigid-cluster model and apply it to a variety of macromolecular assemblies. Rigid-cluster ENI is then modified for a hybrid model represented by a mixture of rigid clusters and point masses. Simulation results show that both rigid-cluster and hybrid ENI methods generate sterically feasible pathways of large systems in a very short time. For example, the HK97 virus capsid is an icosahedral symmetric assembly composed of 60 identical asymmetric units. Its original Hessian matrix size for a Cα coarse-grained model is >(300,000)2. However, it reduces to (84)2 when we apply the rigid-cluster model with icosahedral symmetry constraints. The computational cost of the interpolation no longer scales heavily with the size of structures; instead, it depends strongly on the minimal number of rigid clusters into which the system can be decomposed. PMID:15833998

  6. Deducing protein structures using logic programming: exploiting minimum data of diverse types.

    PubMed

    Sibbald, P R

    1995-04-21

    The extent to which a protein can be modeled from constraint data depends on the amount and quality of the data. This report quantifies a relationship between the amount of data and the achievable model resolution. In an information-theoretic framework the number of bits of information per residue needed to constrain a solution was calculated. The number of bits provided by different kinds of constraints was estimated from a tetrahedral lattice where all unique molecules of 6, 9, ..., 21 atoms were enumerated. Subsets of these molecules consistent with different constraint sets were then chosen, counted, and the root-mean-square distance between them calculated. This provided the desired relations. In a discrete system the number of possible models can be severely limited with relatively few constraints. An expert system that can model a protein from data of different types was built to illustrate the principle and was tested using known proteins as examples. C-alpha resolutions of 5 A are obtainable from 5 bits of information per amino acid and, in principle, from data that could be rapidly collected using standard biophysical techniques.

  7. Solving and Learning Soft Temporal Constraints: Experimental Scenario and Examples

    NASA Technical Reports Server (NTRS)

    Rossi, F.; Venable, K. B.; Sperduti, A.; Khatib, L.; Morris, P.; Morris, R.; Koga, Dennis (Technical Monitor)

    2001-01-01

    Soft temporal constraint problems allow to describe in a natural way scenarios where events happen over time and preferences are associated to event distances and durations. However, sometimes such local preferences are difficult to set, and it may be easier instead to associate preferences to some complete solutions of the problem. To model everything in a uniform way via local preferences only, and also to take advantage of the existing constraint solvers which exploit only local preference use machine learning techniques which learn the local preferences from the global ones. In this paper we describe the existing framework for both solving and learning preferences in temporal constraint problems, the implemented modules, the experimental scenario, and preliminary results on some examples.

  8. Approximate Bayesian computation for forward modeling in cosmology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Akeret, Joël; Refregier, Alexandre; Amara, Adam

    Bayesian inference is often used in cosmology and astrophysics to derive constraints on model parameters from observations. This approach relies on the ability to compute the likelihood of the data given a choice of model parameters. In many practical situations, the likelihood function may however be unavailable or intractable due to non-gaussian errors, non-linear measurements processes, or complex data formats such as catalogs and maps. In these cases, the simulation of mock data sets can often be made through forward modeling. We discuss how Approximate Bayesian Computation (ABC) can be used in these cases to derive an approximation to themore » posterior constraints using simulated data sets. This technique relies on the sampling of the parameter set, a distance metric to quantify the difference between the observation and the simulations and summary statistics to compress the information in the data. We first review the principles of ABC and discuss its implementation using a Population Monte-Carlo (PMC) algorithm and the Mahalanobis distance metric. We test the performance of the implementation using a Gaussian toy model. We then apply the ABC technique to the practical case of the calibration of image simulations for wide field cosmological surveys. We find that the ABC analysis is able to provide reliable parameter constraints for this problem and is therefore a promising technique for other applications in cosmology and astrophysics. Our implementation of the ABC PMC method is made available via a public code release.« less

  9. Constraints on the Energy Content of the Universe from a Combination of Galaxy Cluster Observables

    NASA Technical Reports Server (NTRS)

    Molnar, Sandor M.; Haiman, Zoltan; Birkinshaw, Mark; Mushotzky, Richard F.

    2003-01-01

    We demonstrate that constraints on cosmological parameters from the distribution of clusters as a function of redshift (dN/dz) are complementary to accurate angular diameter distance (D(sub A)) measurements to clusters, and their combination significantly tightens constraints on the energy density content of the Universe. The number counts can be obtained from X-ray and/or SZ (Sunyaev-Ze'dovich effect) surveys, and the angular diameter distances can be determined from deep observations of the intra-cluster gas using their thermal bremsstrahlung X-ray emission and the SZ effect. We combine constraints from simulated cluster number counts expected from a 12 deg(sup 2) SZ cluster survey and constraints from simulated angular diameter distance measurements based on the X-ray/SZ method assuming a statistical accuracy of 10% in the angular diameter distance determination of 100 clusters with redshifts less than 1.5. We find that Omega(sub m), can be determined within about 25%, Omega(sub lambda) within 20% and w within 16%. We show that combined dN/dz+(sub lambda) constraints can be used to constrain the different energy densities in the Universe even in the presence of a few percent redshift dependent systematic error in D(sub lambda). We also address the question of how best to select clusters of galaxies for accurate diameter distance determinations. We show that the joint dN/dz+ D(lambda) constraints on cosmological parameters for a fixed target accuracy in the energy density parameters are optimized by selecting clusters with redshift upper cut-offs in the range 0.55 approx. less than 1. Subject headings: cosmological parameters - cosmology: theory - galaxies:clusters: general

  10. Constraints on the Energy Density Content of the Universe Using Only Clusters of Galaxies

    NASA Technical Reports Server (NTRS)

    Molnar, Sandor M.; Haiman, Zoltan; Birkinshaw, Mark

    2003-01-01

    We demonstrate that it is possible to constrain the energy content of the Universe with high accuracy using observations of clusters of galaxies only. The degeneracies in the cosmological parameters are lifted by combining constraints from different observables of galaxy clusters. We show that constraints on cosmological parameters from galaxy cluster number counts as a function of redshift and accurate angular diameter distance measurements to clusters are complementary to each other and their combination can constrain the energy density content of the Universe well. The number counts can be obtained from X-ray and/or SZ (Sunyaev-Zeldovich effect) surveys, the angular diameter distances can be determined from deep observations of the intra-cluster gas using their thermal bremsstrahlung X-ray emission and the SZ effect (X-SZ method). In this letter we combine constraints from simulated cluster number counts expected from a 12 deg2 SZ cluster survey and constraints from simulated angular diameter distance measurements based on using the X-SZ method assuming an expected accuracy of 7% in the angular diameter distance determination of 70 clusters with redshifts less than 1.5. We find that R, can be determined within about 25%, A within 20%, and w within 16%. Any cluster survey can be used to select clusters for high accuracy distance measurements, but we assumed accurate angular diameter distance measurements for only 70 clusters since long observations are necessary to achieve high accuracy in distance measurements. Thus the question naturally arises: How to select clusters of galaxies for accurate diameter distance determinations? In this letter, as an example, we demonstrate that it is possible to optimize this selection changing the number of clusters observed, and the upper cut off of their redshift range. We show that constraints on cosmological parameters from combining cluster number counts and angular diameter distance measurements, as opposed to general expectations, will not improve substantially selecting clusters with redshifts higher than one. This important conclusion allow us to restrict our cluster sample to clusters closer than one, in a range where the observational time for accurate distance measurements are more manageable. Subject headings: cosmological parameters - cosmology: theory - galaxies: clusters: general - X-rays: galaxies: clusters

  11. Constraining the location of gamma-ray flares in luminous blazars

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nalewajko, Krzysztof; Begelman, Mitchell C.; Sikora, Marek, E-mail: knalew@jila.colorado.edu

    2014-07-10

    Locating the gamma-ray emission sites in blazar jets is a long standing and highly controversial issue. We jointly investigate several constraints on the distance scale r and Lorentz factor Γ of the gamma-ray emitting regions in luminous blazars (primarily flat spectrum radio quasars). Working in the framework of one-zone external radiation Comptonization models, we perform a parameter space study for several representative cases of actual gamma-ray flares in their multiwavelength context. We find a particularly useful combination of three constraints: from an upper limit on the collimation parameter Γθ ≲ 1, from an upper limit on the synchrotron self-Compton (SSC)more » luminosity L{sub SSC} ≲ L{sub X}, and from an upper limit on the efficient cooling photon energy E{sub cool,obs} ≲ 100 MeV. These three constraints are particularly strong for sources with low accretion disk luminosity L{sub d}. The commonly used intrinsic pair-production opacity constraint on Γ is usually much weaker than the SSC constraint. The SSC and cooling constraints provide a robust lower limit on the collimation parameter Γθ ≳ 0.1-0.7. Typical values of r corresponding to moderate values of Γ ∼ 20 are in the range 0.1-1 pc, and are determined primarily by the observed variability timescale t{sub var,obs}. Alternative scenarios motivated by the observed gamma-ray/millimeter connection, in which gamma-ray flares of t{sub var,obs} ∼ a few days are located at r ∼ 10 pc, are in conflict with both the SSC and cooling constraints. Moreover, we use a simple light travel time argument to point out that the gamma-ray/millimeter connection does not provide a significant constraint on the location of gamma-ray flares. We argue that spine-sheath models of the jet structure do not offer a plausible alternative to external radiation fields at large distances; however, an extended broad-line region is an idea worth exploring. We propose that the most definite additional constraint could be provided by determination of the synchrotron self-absorption frequency for correlated synchrotron and gamma-ray flares.« less

  12. Fuzzy bi-objective preventive health care network design.

    PubMed

    Davari, Soheil; Kilic, Kemal; Ertek, Gurdal

    2015-09-01

    Preventive health care is unlike health care for acute ailments, as people are less alert to their unknown medical problems. In order to motivate public and to attain desired participation levels for preventive programs, the attractiveness of the health care facility is a major concern. Health economics literature indicates that attractiveness of a facility is significantly influenced by proximity of the clients to it. Hence attractiveness is generally modelled as a function of distance. However, abundant empirical evidence suggests that other qualitative factors such as perceived quality, attractions nearby, amenities, etc. also influence attractiveness. Therefore, a realistic measure should incorporate the vagueness in the concept of attractiveness to the model. The public policy makers should also maintain the equity among various neighborhoods, which should be considered as a second objective. Finally, even though the general tendency in the literature is to focus on health benefits, the cost effectiveness is still a factor that should be considered. In this paper, a fuzzy bi-objective model with budget constraints is developed. Later, by modelling the attractiveness by means of fuzzy triangular numbers and treating the budget constraint as a soft constraint, a modified (and more realistic) version of the model is introduced. Two solution methodologies, namely fuzzy goal programming and fuzzy chance constrained optimization are proposed as solutions. Both the original and the modified models are solved within the framework of a case study in Istanbul, Turkey. In the case study, the Microsoft Bing Map is utilized in order to determine more accurate distance measures among the nodes.

  13. Dependency distance: A new perspective on syntactic patterns in natural languages.

    PubMed

    Liu, Haitao; Xu, Chunshan; Liang, Junying

    2017-07-01

    Dependency distance, measured by the linear distance between two syntactically related words in a sentence, is generally held as an important index of memory burden and an indicator of syntactic difficulty. Since this constraint of memory is common for all human beings, there may well be a universal preference for dependency distance minimization (DDM) for the sake of reducing memory burden. This human-driven language universal is supported by big data analyses of various corpora that consistently report shorter overall dependency distance in natural languages than in artificial random languages and long-tailed distributions featuring a majority of short dependencies and a minority of long ones. Human languages, as complex systems, seem to have evolved to come up with diverse syntactic patterns under the universal pressure for dependency distance minimization. However, there always exist a small number of long-distance dependencies in natural languages, which may reflect some other biological or functional constraints. Language system may adapt itself to these sporadic long-distance dependencies. It is these universal constraints that have shaped such a rich diversity of syntactic patterns in human languages. Copyright © 2017. Published by Elsevier B.V.

  14. Nonlinear evolution of coarse-grained quantum systems with generalized purity constraints

    NASA Astrophysics Data System (ADS)

    Burić, Nikola

    2010-12-01

    Constrained quantum dynamics is used to propose a nonlinear dynamical equation for pure states of a generalized coarse-grained system. The relevant constraint is given either by the generalized purity or by the generalized invariant fluctuation, and the coarse-grained pure states correspond to the generalized coherent, i.e. generalized nonentangled states. Open system model of the coarse-graining is discussed. It is shown that in this model and in the weak coupling limit the constrained dynamical equations coincide with an equation for pointer states, based on Hilbert-Schmidt distance, that was previously suggested in the context of the decoherence theory.

  15. Noise-assisted energy transfer from the dilation of the set of one-electron reduced density matrices

    NASA Astrophysics Data System (ADS)

    Chakraborty, Romit; Mazziotti, David A.

    2017-05-01

    Noise-assisted energy transfer can be explained geometrically in terms of the set of one-electron reduced density matrices (1-RDMs) [R. Chakraborty and D. A. Mazziotti, Phys. Rev. A 91, 010101(R) (2015)]. In this paper, we examine the geometric picture of quantum noise for the seven-chromophore Fenna-Matthews-Olson (FMO) complex. Noise expands the feasible set of orbital occupation trajectories to the target state through the violation of the pure-state N-representability conditions on the 1-RDM, known as the generalized Pauli constraints. While the generalized Pauli constraints are not explicitly known for seven-electron systems, we are able to treat a seven-exciton model of the FMO complex through the use of generalized Pauli constraints for p qubits which are known for arbitrary p. In the model, we find that while dephasing noise alone produces a trajectory of ensemble states that neither expands the set of 1-RDMs nor reaches the reaction center, the inclusion of both dephasing and dissipation expands the set of 1-RDMs and exhibits an efficient energy transfer to the reaction center. The degree to which the noise expands the set of 1-RDMs, violating the generalized Pauli constraints, is quantified by the distance of the 1-RDM outside its pure set to the distance of the 1-RDM inside its ensemble set. The geometric picture of energy transfer has applications to general quantum systems in chemistry and physics.

  16. Sunyaev-Zel'dovich Effect Derived Distance to the High Redshift Clusters MS 0451.6-0305 and CL 0016+16

    NASA Technical Reports Server (NTRS)

    Reese, E. D.; Mohr, J. J.; Carlstrom, J. E.; Grego, L.; Holder, G. P.; Holzapfel, W. L.; Hughes, J. P.; Patel, S. K.

    2000-01-01

    We determine the distances to the z approximately equal to 0.55 galaxy clusters MS 0451.6-0305 and CL 0016+16 from a maximum likelihood joint fit to interferometric Sunyaev-Zel'dovich effect (SZE) and X-ray observations. We model the intracluster medium (ICM) using a spherical isothermal beta-model. We quantify the statistical and systematic uncertainties inherent to these direct distance measurements, and we determine constraints on the Hubble parameter for three different cosmologies. For an OmegaM = 0.3, OmegaL = 0.7 cosmology, these distances imply a Hubble constant of 63(exp 12)(sub -9)(exp +21)(sub -21) km/s/Mpc, where the uncertainties correspond to statistical followed by systematic at 68% confidence. The best fit H(sub o) is 57 km/sec/Mpc for an open OmegaM = 0.3 universe and 52 km/s/Mpc for a flat Omega = 1 universe.

  17. Sunyaev-Zeldovich Effect-Derived Distances to the High-Redshift Clusters

    NASA Technical Reports Server (NTRS)

    Reese, Erik D.; Mohr, Joseph J.; Carlstrom, John E.; Joy, Marshall; Grego, Laura; Holder, Gilbert P.; Holzapfel, William L.; Hughes, John P.; Patel, Sandeep K.; Donahue, Megan

    2000-01-01

    We determine the distances to the z approximately equals 0.55 galaxy clusters MS 0451.6 - 0305 and Cl 0016 + 16 from a maximum-likelihood joint fit to interferometric Sunyaev-Zeldovich effect (SZE) and X-ray observations. We model the intracluster medium (ICM) using a spherical isothermal beta model. We quantify the statistical and systematic uncertainties inherent to these direct distance measurements, and we determine constraints on the Hubble parameter for three different cosmologies. For an Omega(sub M) = 0.3, Omega(sub lambda) = 0.7 cosmology, these distances imply a Hubble constant of 63(sup +12) (sub -9) (sup + 21) (sub -21) km/s Mp/c, where the uncertainties correspond to statistical followed by systematic at 68% confidence. The best-fit H(sub 0) is 57 km/s Mp/c for an open (Omega(sub M) = 0.3) universe and 52 km/s Mp/c for a flat (Omega(sub M) = 1) universe.

  18. Improved Constraints on H 0 from a Combined Analysis of Gravitational-wave and Electromagnetic Emission from GW170817

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Guidorzi, C.; Margutti, R.; Brout, D.

    The luminosity distance measurement of GW170817 derived from gravitational-wave analysis in Abbott et al. (2017a, hereafter A17:H0) is highly correlated with the measured inclination of the NS–NS system. To improve the precision of the distance measurement, we attempt to constrain the inclination by modeling the broadband X-ray-to-radio emission from GW170817, which is dominated by the interaction of the jet with the environment. We update our previous analysis and we consider the radio and X-ray data obtained at t < 40 days since merger. We find that the afterglow emission from GW170817 is consistent with an off-axis relativistic jet with energy E k~10 48 -3 × 10 50 erg propagating into an environment with density n ~ 10 -2–10-4 cm-3, with preference for wider jets (opening angle θ j = 15°). For these jets, our modeling indicates an off-axis angle θ obs ~25°–50°. We combine our constraints on θ obs with the joint distance–inclination constraint from LIGO. Using the same ~170 km s -1 peculiar velocity uncertainty assumed in A17:H0 but with an inclination constraint from the afterglow data, we get a value of H 0 =74.0 ±more » $$\\frac{11.5}{7.5}$$ km s -1 Mpc -1, which is higher than the value of H 0 70.0 ± $$\\frac{12.0}{8.0}$$ km s -1 Mpc -1 found in A17:H0. Further, using a more realistic peculiar velocity uncertainty of 250 km s -1 derived from previous work, we find km s -1 Mpc -1 for H 0 from this system. This is in modestly better agreement with the local distance ladder than the Planck cosmic microwave background, though such a significant discrimination will require ~50 such events. Finally, measurements at t > 100 days of the X-ray and radio emission will lead to tighter constraints.« less

  19. Improved Constraints on H 0 from a Combined Analysis of Gravitational-wave and Electromagnetic Emission from GW170817

    DOE PAGES

    Guidorzi, C.; Margutti, R.; Brout, D.; ...

    2017-12-18

    The luminosity distance measurement of GW170817 derived from gravitational-wave analysis in Abbott et al. (2017a, hereafter A17:H0) is highly correlated with the measured inclination of the NS–NS system. To improve the precision of the distance measurement, we attempt to constrain the inclination by modeling the broadband X-ray-to-radio emission from GW170817, which is dominated by the interaction of the jet with the environment. We update our previous analysis and we consider the radio and X-ray data obtained at t < 40 days since merger. We find that the afterglow emission from GW170817 is consistent with an off-axis relativistic jet with energy E k~10 48 -3 × 10 50 erg propagating into an environment with density n ~ 10 -2–10-4 cm-3, with preference for wider jets (opening angle θ j = 15°). For these jets, our modeling indicates an off-axis angle θ obs ~25°–50°. We combine our constraints on θ obs with the joint distance–inclination constraint from LIGO. Using the same ~170 km s -1 peculiar velocity uncertainty assumed in A17:H0 but with an inclination constraint from the afterglow data, we get a value of H 0 =74.0 ±more » $$\\frac{11.5}{7.5}$$ km s -1 Mpc -1, which is higher than the value of H 0 70.0 ± $$\\frac{12.0}{8.0}$$ km s -1 Mpc -1 found in A17:H0. Further, using a more realistic peculiar velocity uncertainty of 250 km s -1 derived from previous work, we find km s -1 Mpc -1 for H 0 from this system. This is in modestly better agreement with the local distance ladder than the Planck cosmic microwave background, though such a significant discrimination will require ~50 such events. Finally, measurements at t > 100 days of the X-ray and radio emission will lead to tighter constraints.« less

  20. Improved Constraints on H 0 from a Combined Analysis of Gravitational-wave and Electromagnetic Emission from GW170817

    NASA Astrophysics Data System (ADS)

    Guidorzi, C.; Margutti, R.; Brout, D.; Scolnic, D.; Fong, W.; Alexander, K. D.; Cowperthwaite, P. S.; Annis, J.; Berger, E.; Blanchard, P. K.; Chornock, R.; Coppejans, D. L.; Eftekhari, T.; Frieman, J. A.; Huterer, D.; Nicholl, M.; Soares-Santos, M.; Terreran, G.; Villar, V. A.; Williams, P. K. G.

    2017-12-01

    The luminosity distance measurement of GW170817 derived from gravitational-wave analysis in Abbott et al. (2017a, hereafter A17:H0) is highly correlated with the measured inclination of the NS–NS system. To improve the precision of the distance measurement, we attempt to constrain the inclination by modeling the broadband X-ray-to-radio emission from GW170817, which is dominated by the interaction of the jet with the environment. We update our previous analysis and we consider the radio and X-ray data obtained at t < 40 days since merger. We find that the afterglow emission from GW170817 is consistent with an off-axis relativistic jet with energy E k ∼ 1048 ‑3 × 1050 erg propagating into an environment with density n ∼ 10‑2–10‑4 cm‑3, with preference for wider jets (opening angle θ j = 15°). For these jets, our modeling indicates an off-axis angle θ obs ∼ 25°–50°. We combine our constraints on θ obs with the joint distance–inclination constraint from LIGO. Using the same ∼170 km s‑1 peculiar velocity uncertainty assumed in A17:H0 but with an inclination constraint from the afterglow data, we get a value of {H}0=74.0+/- \\tfrac{11.5}{7.5} km s‑1 Mpc‑1, which is higher than the value of {H}0=70.0+/- \\tfrac{12.0}{8.0} km s‑1 Mpc‑1 found in A17:H0. Further, using a more realistic peculiar velocity uncertainty of 250 km s‑1 derived from previous work, we find {H}0=75.5+/- \\tfrac{11.6}{9.6} km s‑1 Mpc‑1 for H 0 from this system. This is in modestly better agreement with the local distance ladder than the Planck cosmic microwave background, though such a significant discrimination will require ∼50 such events. Measurements at t > 100 days of the X-ray and radio emission will lead to tighter constraints.

  1. High-resolution structure of the Shigella type-III secretion needle by solid-state NMR and cryo-electron microscopy

    NASA Astrophysics Data System (ADS)

    Demers, Jean-Philippe; Habenstein, Birgit; Loquet, Antoine; Kumar Vasa, Suresh; Giller, Karin; Becker, Stefan; Baker, David; Lange, Adam; Sgourakis, Nikolaos G.

    2014-09-01

    We introduce a general hybrid approach for determining the structures of supramolecular assemblies. Cryo-electron microscopy (cryo-EM) data define the overall envelope of the assembly and rigid-body orientation of the subunits while solid-state nuclear magnetic resonance (ssNMR) chemical shifts and distance constraints define the local secondary structure, protein fold and inter-subunit interactions. Finally, Rosetta structure calculations provide a general framework to integrate the different sources of structural information. Combining a 7.7-Å cryo-EM density map and 996 ssNMR distance constraints, the structure of the type-III secretion system needle of Shigella flexneri is determined to a precision of 0.4 Å. The calculated structures are cross-validated using an independent data set of 691 ssNMR constraints and scanning transmission electron microscopy measurements. The hybrid model resolves the conformation of the non-conserved N terminus, which occupies a protrusion in the cryo-EM density, and reveals conserved pore residues forming a continuous pattern of electrostatic interactions, thereby suggesting a mechanism for effector protein translocation.

  2. Generating subtour elimination constraints for the TSP from pure integer solutions.

    PubMed

    Pferschy, Ulrich; Staněk, Rostislav

    2017-01-01

    The traveling salesman problem ( TSP ) is one of the most prominent combinatorial optimization problems. Given a complete graph [Formula: see text] and non-negative distances d for every edge, the TSP asks for a shortest tour through all vertices with respect to the distances d. The method of choice for solving the TSP to optimality is a branch and cut approach . Usually the integrality constraints are relaxed first and all separation processes to identify violated inequalities are done on fractional solutions . In our approach we try to exploit the impressive performance of current ILP-solvers and work only with integer solutions without ever interfering with fractional solutions. We stick to a very simple ILP-model and relax the subtour elimination constraints only. The resulting problem is solved to integer optimality, violated constraints (which are trivial to find) are added and the process is repeated until a feasible solution is found. In order to speed up the algorithm we pursue several attempts to find as many relevant subtours as possible. These attempts are based on the clustering of vertices with additional insights gained from empirical observations and random graph theory. Computational results are performed on test instances taken from the TSPLIB95 and on random Euclidean graphs .

  3. New t-gap insertion-deletion-like metrics for DNA hybridization thermodynamic modeling.

    PubMed

    D'yachkov, Arkadii G; Macula, Anthony J; Pogozelski, Wendy K; Renz, Thomas E; Rykov, Vyacheslav V; Torney, David C

    2006-05-01

    We discuss the concept of t-gap block isomorphic subsequences and use it to describe new abstract string metrics that are similar to the Levenshtein insertion-deletion metric. Some of the metrics that we define can be used to model a thermodynamic distance function on single-stranded DNA sequences. Our model captures a key aspect of the nearest neighbor thermodynamic model for hybridized DNA duplexes. One version of our metric gives the maximum number of stacked pairs of hydrogen bonded nucleotide base pairs that can be present in any secondary structure in a hybridized DNA duplex without pseudoknots. Thermodynamic distance functions are important components in the construction of DNA codes, and DNA codes are important components in biomolecular computing, nanotechnology, and other biotechnical applications that employ DNA hybridization assays. We show how our new distances can be calculated by using a dynamic programming method, and we derive a Varshamov-Gilbert-like lower bound on the size of some of codes using these distance functions as constraints. We also discuss software implementation of our DNA code design methods.

  4. DNS and modeling of the interaction between turbulent premixed flames and walls

    NASA Technical Reports Server (NTRS)

    Poinsot, T. J.; Haworth, D. C.

    1992-01-01

    The interaction between turbulent premixed flames and walls is studied using a two-dimensional full Navier-Stokes solver with simple chemistry. The effects of wall distance on the local and global flame structure are investigated. Quenching distances and maximum wall heat fluxes during quenching are computed in laminar cases and are found to be comparable to experimental and analytical results. For turbulent cases, it is shown that quenching distances and maximum heat fluxes remain of the same order as for laminar flames. Based on simulation results, a 'law-of-the-wall' model is derived to describe the interaction between a turbulent premixed flame and a wall. This model is constructed to provide reasonable behavior of flame surface density near a wall under the assumption that flame-wall interaction takes place at scales smaller than the computational mesh. It can be implemented in conjunction with any of several recent flamelet models based on a modeled surface density equation, with no additional constraints on mesh size or time step.

  5. Hot hands, cold feet? Investigating effects of interacting constraints on place kicking performance at the 2015 Rugby Union World Cup.

    PubMed

    Pocock, Chris; Bezodis, Neil E; Davids, Keith; North, Jamie S

    2018-06-23

    Place kicks in Rugby Union present valuable opportunities to score points outside the spatiotemporal dynamics of open play but are executed under varying performance constraints. We analysed effects of specific task constraints and relevant contextual factors on place kick performance in the 2015 Rugby Union World Cup. Data were collected from television broadcasts for each place kick. In addition to kick outcomes, contextual factors, including time of the kick in the match, score margin at the time of the kick, and outcome of the kicker's previous kick, were recorded. Effects of spatial task constraints were analysed for each kick, using distance (m) and angle (°) of the kick to the goalposts. A binomial logistic regression model revealed that distance from, and angle to, the goalposts were significant predictors of place kick outcome. Furthermore, the success percentage of kickers who missed their previous kick was 7% lower than those who scored their previous kick. Place kick success percentage in the 10 minutes before half-time was 8% lower than the mean tournament success percentage, which was 75% (95% CI 71-78%). The highest kick success percentage was recorded when scores were level (83%; 95% CI 72-91%). Our data highlighted how subtle changes in task constraints and contextual factors can influence performance outcomes in elite performers in international competition. Fluctuations in place kick success suggested that individual constraints, such as thoughts, emotions and fatigue, induced during competition, could interact with perceptions to influence emergent performance behaviours.

  6. Producing Distance Learning Materials: Cash and Other Constraints.

    ERIC Educational Resources Information Center

    Whitehead, Don J.

    In order to develop a financial plan for and identify constraints on the production of distance learning materials, a total human resources development (HRD) plan must be produced, and endorsed by the highest level of management. The HRD plan sets out the human resources needed to secure the organization's future in terms of people and their…

  7. A virtual pebble game to ensemble average graph rigidity.

    PubMed

    González, Luis C; Wang, Hui; Livesay, Dennis R; Jacobs, Donald J

    2015-01-01

    The body-bar Pebble Game (PG) algorithm is commonly used to calculate network rigidity properties in proteins and polymeric materials. To account for fluctuating interactions such as hydrogen bonds, an ensemble of constraint topologies are sampled, and average network properties are obtained by averaging PG characterizations. At a simpler level of sophistication, Maxwell constraint counting (MCC) provides a rigorous lower bound for the number of internal degrees of freedom (DOF) within a body-bar network, and it is commonly employed to test if a molecular structure is globally under-constrained or over-constrained. MCC is a mean field approximation (MFA) that ignores spatial fluctuations of distance constraints by replacing the actual molecular structure by an effective medium that has distance constraints globally distributed with perfect uniform density. The Virtual Pebble Game (VPG) algorithm is a MFA that retains spatial inhomogeneity in the density of constraints on all length scales. Network fluctuations due to distance constraints that may be present or absent based on binary random dynamic variables are suppressed by replacing all possible constraint topology realizations with the probabilities that distance constraints are present. The VPG algorithm is isomorphic to the PG algorithm, where integers for counting "pebbles" placed on vertices or edges in the PG map to real numbers representing the probability to find a pebble. In the VPG, edges are assigned pebble capacities, and pebble movements become a continuous flow of probability within the network. Comparisons between the VPG and average PG results over a test set of proteins and disordered lattices demonstrate the VPG quantitatively estimates the ensemble average PG results well. The VPG performs about 20% faster than one PG, and it provides a pragmatic alternative to averaging PG rigidity characteristics over an ensemble of constraint topologies. The utility of the VPG falls in between the most accurate but slowest method of ensemble averaging over hundreds to thousands of independent PG runs, and the fastest but least accurate MCC.

  8. Change in collateral ligament length and tibiofemoral movement following joint line variation in TKA.

    PubMed

    Lin, Kun-Jhih; Wei, Hung-Wen; Huang, Chang-Hung; Liu, Yu-Liang; Chen, Wen-Chuan; McClean, Colin Joseph; Cheng, Cheng-Kung

    2016-08-01

    The primary intent of total knee arthroplasty is the restoration of normal knee kinematics, with ligamentous constraint being a key influential factor. Displacement of the joint line may lead to alterations in ligament attachment sites relative to knee flexion axis and variance of ligamentous constraints on tibiofemoral movement. This study aimed to investigate collaterals strains and tibiofemoral kinematics with different joint line levels. A previously validated knee model was employed to analyse the change in length of the collateral ligaments and tibiofemoral motion during knee flexion. The models shifted the joint line by 3 and 5 mm both proximally and distally from the anatomical level. The data were captured from full extension to flexion 135°. The elevated joint line revealed a relative increase in distance between ligament attachments for both collateral ligaments in comparison with the anatomical model. Also, tibiofemoral movement decreased with an elevation in the joint line. Conversely, lowering the joint line led to a significant decrease in distance between ligament attachments, but greater tibiofemoral motion. Elevation of the joint line would strengthen the capacity of collateral ligaments for knee motion constraint, whereas a distally shifted joint line might have the advantage of improving tibiofemoral movement by slackening the collaterals. It implies that surgeons can appropriately change the joint line position in accordance with patient's requirement or collateral tensions. A lowered joint line level may improve knee kinematics, whereas joint line elevation could be useful to maintain knee stability. V.

  9. Relative Packing Groups in Template-Based Structure Prediction: Cooperative Effects of True Positive Constraints

    PubMed Central

    Day, Ryan; Qu, Xiaotao; Swanson, Rosemarie; Bohannan, Zach; Bliss, Robert

    2011-01-01

    Abstract Most current template-based structure prediction methods concentrate on finding the correct backbone conformation and then packing sidechains within that backbone. Our packing-based method derives distance constraints from conserved relative packing groups (RPGs). In our refinement approach, the RPGs provide a level of resolution that restrains global topology while allowing conformational sampling. In this study, we test our template-based structure prediction method using 51 prediction units from CASP7 experiments. RPG-based constraints are able to substantially improve approximately two-thirds of starting templates. Upon deeper investigation, we find that true positive spatial constraints, especially those non-local in sequence, derived from the RPGs were important to building nearer native models. Surprisingly, the fraction of incorrect or false positive constraints does not strongly influence the quality of the final candidate. This result indicates that our RPG-based true positive constraints sample the self-consistent, cooperative interactions of the native structure. The lack of such reinforcing cooperativity explains the weaker effect of false positive constraints. Generally, these findings are encouraging indications that RPGs will improve template-based structure prediction. PMID:21210729

  10. Quantum centipedes with strong global constraint

    NASA Astrophysics Data System (ADS)

    Grange, Pascal

    2017-06-01

    A centipede made of N quantum walkers on a one-dimensional lattice is considered. The distance between two consecutive legs is either one or two lattice spacings, and a global constraint is imposed: the maximal distance between the first and last leg is N  +  1. This is the strongest global constraint compatible with walking. For an initial value of the wave function corresponding to a localized configuration at the origin, the probability law of the first leg of the centipede can be expressed in closed form in terms of Bessel functions. The dispersion relation and the group velocities are worked out exactly. Their maximal group velocity goes to zero when N goes to infinity, which is in contrast with the behaviour of group velocities of quantum centipedes without global constraint, which were recently shown by Krapivsky, Luck and Mallick to give rise to ballistic spreading of extremal wave-front at non-zero velocity in the large-N limit. The corresponding Hamiltonians are implemented numerically, based on a block structure of the space of configurations corresponding to compositions of the integer N. The growth of the maximal group velocity when the strong constraint is gradually relaxed is explored, and observed to be linear in the density of gaps allowed in the configurations. Heuristic arguments are presented to infer that the large-N limit of the globally constrained model can yield finite group velocities provided the allowed number of gaps is a finite fraction of N.

  11. Observational constraint on spherical inhomogeneity with CMB and local Hubble parameter

    NASA Astrophysics Data System (ADS)

    Tokutake, Masato; Ichiki, Kiyotomo; Yoo, Chul-Moon

    2018-03-01

    We derive an observational constraint on a spherical inhomogeneity of the void centered at our position from the angular power spectrum of the cosmic microwave background (CMB) and local measurements of the Hubble parameter. The late time behaviour of the void is assumed to be well described by the so-called Λ-Lemaȋtre-Tolman-Bondi (ΛLTB) solution. Then, we restrict the models to the asymptotically homogeneous models each of which is approximated by a flat Friedmann-Lemaȋtre-Robertson-Walker model. The late time ΛLTB models are parametrized by four parameters including the value of the cosmological constant and the local Hubble parameter. The other two parameters are used to parametrize the observed distance-redshift relation. Then, the ΛLTB models are constructed so that they are compatible with the given distance-redshift relation. Including conventional parameters for the CMB analysis, we characterize our models by seven parameters in total. The local Hubble measurements are reflected in the prior distribution of the local Hubble parameter. As a result of a Markov-Chains-Monte-Carlo analysis for the CMB temperature and polarization anisotropies, we found that the inhomogeneous universe models with vanishing cosmological constant are ruled out as is expected. However, a significant under-density around us is still compatible with the angular power spectrum of CMB and the local Hubble parameter.

  12. Gene Expression Data to Mouse Atlas Registration Using a Nonlinear Elasticity Smoother and Landmark Points Constraints

    PubMed Central

    Lin, Tungyou; Guyader, Carole Le; Dinov, Ivo; Thompson, Paul; Toga, Arthur; Vese, Luminita

    2013-01-01

    This paper proposes a numerical algorithm for image registration using energy minimization and nonlinear elasticity regularization. Application to the registration of gene expression data to a neuroanatomical mouse atlas in two dimensions is shown. We apply a nonlinear elasticity regularization to allow larger and smoother deformations, and further enforce optimality constraints on the landmark points distance for better feature matching. To overcome the difficulty of minimizing the nonlinear elasticity functional due to the nonlinearity in the derivatives of the displacement vector field, we introduce a matrix variable to approximate the Jacobian matrix and solve for the simplified Euler-Lagrange equations. By comparison with image registration using linear regularization, experimental results show that the proposed nonlinear elasticity model also needs fewer numerical corrections such as regridding steps for binary image registration, it renders better ground truth, and produces larger mutual information; most importantly, the landmark points distance and L2 dissimilarity measure between the gene expression data and corresponding mouse atlas are smaller compared with the registration model with biharmonic regularization. PMID:24273381

  13. Observational constraints on extended Chaplygin gas cosmologies

    NASA Astrophysics Data System (ADS)

    Paul, B. C.; Thakur, P.; Saha, A.

    2017-08-01

    We investigate cosmological models with extended Chaplygin gas (ECG) as a candidate for dark energy and determine the equation of state parameters using observed data namely, observed Hubble data, baryon acoustic oscillation data and cosmic microwave background shift data. Cosmological models are investigated considering cosmic fluid which is an extension of Chaplygin gas, however, it reduces to modified Chaplygin gas (MCG) and also to generalized Chaplygin gas (GCG) in special cases. It is found that in the case of MCG and GCG, the best-fit values of all the parameters are positive. The distance modulus agrees quite well with the experimental Union2 data. The speed of sound obtained in the model is small, necessary for structure formation. We also determine the observational constraints on the constants of the ECG equation.

  14. Effects of neutrino mass hierarchies on dynamical dark energy models

    NASA Astrophysics Data System (ADS)

    Yang, Weiqiang; Nunes, Rafael C.; Pan, Supriya; Mota, David F.

    2017-05-01

    We investigate how three different possibilities of neutrino mass hierarchies, namely normal, inverted, and degenerate, can affect the observational constraints on three well-known dynamical dark energy models, namely the Chevallier-Polarski-Linder, logarithmic, and the Jassal-Bagla-Padmanabhan parametrizations. In order to impose the observational constraints on the models, we performed a robust analysis using Planck 2015 temperature and polarization data, supernovae type Ia from the joint light curve analysis, baryon acoustic oscillation distance measurements, redshift space distortion characterized by f (z )σ8(z ) data, weak gravitational lensing data from the Canada-France-Hawaii Telescope Lensing Survey, and cosmic chronometer data plus the local value of the Hubble parameter. We find that different neutrino mass hierarchies return similar fits on almost all model parameters and mildly change the dynamical dark energy properties.

  15. Constraints on flavor-dependent long range forces from solar neutrinos and KamLAND

    NASA Astrophysics Data System (ADS)

    Bandyopadhyay, Abhijit; Dighe, Amol; Joshipura, Anjan S.

    2007-05-01

    Flavor-dependent long range (LR) leptonic forces, like those mediated by the Le-Lμ or Le-Lτ gauge bosons, constitute a minimal extension of the standard model that preserves its renormalizability. We study the impact of such interactions on the solar neutrino oscillations when the interaction range RLR is much larger than the Earth-Sun distance. The LR potential can dominate over the standard charged current potential inside the Sun in spite of strong constraints on the coupling α of the LR force coming from the atmospheric neutrino data and laboratory search for new forces. We demonstrate that the solar and atmospheric neutrino mass scales do not get trivially decoupled even if θ13 is vanishingly small. In addition, for α≳10-52 and normal hierarchy, resonant enhancement of θ13 results in nontrivial energy dependent effects on the νe survival probability. We perform a complete three generation analysis, and obtain constraints on α through a global fit to the solar neutrino and KamLAND data. We get the 3σ limits αeμ<3.4×10-53 and αeτ<2.5×10-53 when RLR is much smaller than our distance from the galactic center. With larger RLR, the collective LR potential due to all the electrons in the galaxy becomes significant and the constraints on α become stronger by up to two orders of magnitude.

  16. Dependency Distance Differences across Interpreting Types: Implications for Cognitive Demand

    PubMed Central

    Liang, Junying; Fang, Yuanyuan; Lv, Qianxi; Liu, Haitao

    2017-01-01

    Interpreting is generally recognized as a particularly demanding language processing task for the cognitive system. Dependency distance, the linear distance between two syntactically related words in a sentence, is an index of sentence complexity and is also able to reflect the cognitive constraints during various tasks. In the current research, we examine the difference in dependency distance among three interpreting types, namely, simultaneous interpreting, consecutive interpreting and read-out translated speech based on a treebank comprising these types of interpreting output texts with dependency annotation. Results show that different interpreting renditions yield different dependency distances, and consecutive interpreting texts entail the smallest dependency distance other than those of simultaneous interpreting and read-out translated speech, suggesting that consecutive interpreting bears heavier cognitive demands than simultaneous interpreting. The current research suggests for the first time that interpreting is an extremely demanding cognitive task that can further mediate the dependency distance of output sentences. Such findings may be due to the minimization of dependency distance under cognitive constraints. PMID:29312027

  17. Dark energy equation of state parameter and its evolution at low redshift

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tripathi, Ashutosh; Sangwan, Archana; Jassal, H.K., E-mail: ashutosh_tripathi@fudan.edu.cn, E-mail: archanakumari@iisermohali.ac.in, E-mail: hkjassal@iisermohali.ac.in

    In this paper, we constrain dark energy models using a compendium of observations at low redshifts. We consider the dark energy as a barotropic fluid, with the equation of state a constant as well the case where dark energy equation of state is a function of time. The observations considered here are Supernova Type Ia data, Baryon Acoustic Oscillation data and Hubble parameter measurements. We compare constraints obtained from these data and also do a combined analysis. The combined observational constraints put strong limits on variation of dark energy density with redshift. For varying dark energy models, the range ofmore » parameters preferred by the supernova type Ia data is in tension with the other low redshift distance measurements.« less

  18. Probing structures of large protein complexes using zero-length cross-linking.

    PubMed

    Rivera-Santiago, Roland F; Sriswasdi, Sira; Harper, Sandra L; Speicher, David W

    2015-11-01

    Structural mass spectrometry (MS) is a field with growing applicability for addressing complex biophysical questions regarding proteins and protein complexes. One of the major structural MS approaches involves the use of chemical cross-linking coupled with MS analysis (CX-MS) to identify proximal sites within macromolecules. Identified cross-linked sites can be used to probe novel protein-protein interactions or the derived distance constraints can be used to verify and refine molecular models. This review focuses on recent advances of "zero-length" cross-linking. Zero-length cross-linking reagents do not add any atoms to the cross-linked species due to the lack of a spacer arm. This provides a major advantage in the form of providing more precise distance constraints as the cross-linkable groups must be within salt bridge distances in order to react. However, identification of cross-linked peptides using these reagents presents unique challenges. We discuss recent efforts by our group to minimize these challenges by using multiple cycles of LC-MS/MS analysis and software specifically developed and optimized for identification of zero-length cross-linked peptides. Representative data utilizing our current protocol are presented and discussed. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. New observational constraints on f ( T ) gravity from cosmic chronometers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nunes, Rafael C.; Pan, Supriya; Saridakis, Emmanuel N., E-mail: nunes@ecm.ub.edu, E-mail: span@iiserkol.ac.in, E-mail: Emmanuel_Saridakis@baylor.edu

    2016-08-01

    We use the local value of the Hubble constant recently measured with 2.4% precision, as well as the latest compilation of cosmic chronometers data, together with standard probes such as Supernovae Type Ia and Baryon Acoustic Oscillation distance measurements, in order to impose constraints on the viable and most used f ( T ) gravity models, where T is the torsion scalar in teleparallel gravity. In particular, we consider three f ( T ) models with two parameters, out of which one is independent, and we quantify their deviation from ΛCDM cosmology through a sole parameter. Our analysis reveals thatmore » for one of the models a small but non-zero deviation from ΛCDM cosmology is slightly favored, while for the other models the best fit is very close to ΛCDM scenario. Clearly, f ( T ) gravity is consistent with observations, and it can serve as a candidate for modified gravity.« less

  20. Chemical composition of Mars

    NASA Technical Reports Server (NTRS)

    Morgan, J. W.; Anders, E.

    1979-01-01

    The chemical composition of Mars is estimated from the cosmochemical model of Ganapathy and Anders (1974) with additional petrological and geophysical constraints. The model assumes that planets and chondrites underwent the same fractionation processes in the solar nebula, and constraints are imposed by the abundance of the heat-producing elements, U, Th and K, the volatile-rich component and the high density of the mantle. Global abundances of 83 elements are presented, and it is noted that the mantle is an iron-rich garnet wehrlite, nearly identical to the bulk moon composition of Morgan at al. (1978) and that the core is sulfur poor (3.5% S). The comparison of model compositions for the earth, Venus, Mars, the moon and a eucrite parent body suggests that volatile depletion correlates mainly with size rather than with radial distance from the sun.

  1. Advanced two-layer level set with a soft distance constraint for dual surfaces segmentation in medical images

    NASA Astrophysics Data System (ADS)

    Ji, Yuanbo; van der Geest, Rob J.; Nazarian, Saman; Lelieveldt, Boudewijn P. F.; Tao, Qian

    2018-03-01

    Anatomical objects in medical images very often have dual contours or surfaces that are highly correlated. Manually segmenting both of them by following local image details is tedious and subjective. In this study, we proposed a two-layer region-based level set method with a soft distance constraint, which not only regularizes the level set evolution at two levels, but also imposes prior information on wall thickness in an effective manner. By updating the level set function and distance constraint functions alternatingly, the method simultaneously optimizes both contours while regularizing their distance. The method was applied to segment the inner and outer wall of both left atrium (LA) and left ventricle (LV) from MR images, using a rough initialization from inside the blood pool. Compared to manual annotation from experience observers, the proposed method achieved an average perpendicular distance (APD) of less than 1mm for the LA segmentation, and less than 1.5mm for the LV segmentation, at both inner and outer contours. The method can be used as a practical tool for fast and accurate dual wall annotations given proper initialization.

  2. Topological Constraints in Directed Polymer Melts.

    PubMed

    Serna, Pablo; Bunin, Guy; Nahum, Adam

    2015-11-27

    Polymers in a melt may be subject to topological constraints, as in the example of unlinked polymer rings. How to do statistical mechanics in the presence of such constraints remains a fundamental open problem. We study the effect of topological constraints on a melt of directed polymers, using simulations of a simple quasi-2D model. We find that fixing the global topology of the melt to be trivial changes the polymer conformations drastically. Polymers of length L wander in the transverse direction only by a distance of order (lnL)^{ζ} with ζ≃1.5. This is strongly suppressed in comparison with the Brownian L^{1/2} scaling which holds in the absence of the topological constraint. It is also much smaller than the predictions of standard heuristic approaches-in particular the L^{1/4} of a mean-field-like "array of obstacles" model-so our results present a sharp challenge to theory. Dynamics are also strongly affected by the constraints, and a tagged monomer in an infinite system performs logarithmically slow subdiffusion in the transverse direction. To cast light on the suppression of the strands' wandering, we analyze the topological complexity of subregions of the melt: the complexity is also logarithmically small, and is related to the wandering by a power law. We comment on insights the results give for 3D melts, directed and nondirected.

  3. Near-optimal alternative generation using modified hit-and-run sampling for non-linear, non-convex problems

    NASA Astrophysics Data System (ADS)

    Rosenberg, D. E.; Alafifi, A.

    2016-12-01

    Water resources systems analysis often focuses on finding optimal solutions. Yet an optimal solution is optimal only for the modelled issues and managers often seek near-optimal alternatives that address un-modelled objectives, preferences, limits, uncertainties, and other issues. Early on, Modelling to Generate Alternatives (MGA) formalized near-optimal as the region comprising the original problem constraints plus a new constraint that allowed performance within a specified tolerance of the optimal objective function value. MGA identified a few maximally-different alternatives from the near-optimal region. Subsequent work applied Markov Chain Monte Carlo (MCMC) sampling to generate a larger number of alternatives that span the near-optimal region of linear problems or select portions for non-linear problems. We extend the MCMC Hit-And-Run method to generate alternatives that span the full extent of the near-optimal region for non-linear, non-convex problems. First, start at a feasible hit point within the near-optimal region, then run a random distance in a random direction to a new hit point. Next, repeat until generating the desired number of alternatives. The key step at each iterate is to run a random distance along the line in the specified direction to a new hit point. If linear equity constraints exist, we construct an orthogonal basis and use a null space transformation to confine hits and runs to a lower-dimensional space. Linear inequity constraints define the convex bounds on the line that runs through the current hit point in the specified direction. We then use slice sampling to identify a new hit point along the line within bounds defined by the non-linear inequity constraints. This technique is computationally efficient compared to prior near-optimal alternative generation techniques such MGA, MCMC Metropolis-Hastings, evolutionary, or firefly algorithms because search at each iteration is confined to the hit line, the algorithm can move in one step to any point in the near-optimal region, and each iterate generates a new, feasible alternative. We use the method to generate alternatives that span the near-optimal regions of simple and more complicated water management problems and may be preferred to optimal solutions. We also discuss extensions to handle non-linear equity constraints.

  4. A distance constrained synaptic plasticity model of C. elegans neuronal network

    NASA Astrophysics Data System (ADS)

    Badhwar, Rahul; Bagler, Ganesh

    2017-03-01

    Brain research has been driven by enquiry for principles of brain structure organization and its control mechanisms. The neuronal wiring map of C. elegans, the only complete connectome available till date, presents an incredible opportunity to learn basic governing principles that drive structure and function of its neuronal architecture. Despite its apparently simple nervous system, C. elegans is known to possess complex functions. The nervous system forms an important underlying framework which specifies phenotypic features associated to sensation, movement, conditioning and memory. In this study, with the help of graph theoretical models, we investigated the C. elegans neuronal network to identify network features that are critical for its control. The 'driver neurons' are associated with important biological functions such as reproduction, signalling processes and anatomical structural development. We created 1D and 2D network models of C. elegans neuronal system to probe the role of features that confer controllability and small world nature. The simple 1D ring model is critically poised for the number of feed forward motifs, neuronal clustering and characteristic path-length in response to synaptic rewiring, indicating optimal rewiring. Using empirically observed distance constraint in the neuronal network as a guiding principle, we created a distance constrained synaptic plasticity model that simultaneously explains small world nature, saturation of feed forward motifs as well as observed number of driver neurons. The distance constrained model suggests optimum long distance synaptic connections as a key feature specifying control of the network.

  5. Cosmological Distance Scale to Gamma-Ray Bursts

    NASA Astrophysics Data System (ADS)

    Azzam, W. J.; Linder, E. V.; Petrosian, V.

    1993-05-01

    The source counts or the so-called log N -- log S relations are the primary data that constrain the spatial distribution of sources with unknown distances, such as gamma-ray bursts. In order to test galactic, halo, and cosmological models for gamma-ray bursts we compare theoretical characteristics of the log N -- log S relations to those obtained from data gathered by the BATSE instrument on board the Compton Observatory (GRO) and other instruments. We use a new and statistically correct method, that takes proper account of the variable nature of the triggering threshold, to analyze the data. Constraints on models obtained by this comparison will be presented. This work is supported by NASA grants NAGW 2290, NAG5 2036, and NAG5 1578.

  6. Zygomatic bone shape in intentional cranial deformations: a model for the study of the interactions between skull growth and facial morphology.

    PubMed

    Ketoff, S; Girinon, F; Schlager, S; Friess, M; Schouman, T; Rouch, P; Khonsari, R H

    2017-04-01

    Intentional cranial deformations (ICD) were obtained by exerting external mechanical constraints on the skull vault during the first years of life to permanently modify head shape. The repercussions of ICD on the face are not well described in the midfacial region. Here we assessed the shape of the zygomatic bone in different types of ICDs. We considered 14 non-deformed skulls, 19 skulls with antero-posterior deformation, nine skulls with circumferential deformation and seven skulls with Toulouse deformation. The shape of the zygomatic bone was assessed using a statistical shape model after mesh registration. Euclidian distances between mean models and Mahalanobis distances after canonical variate analysis were computed. Classification accuracy was computed using a cross-validation approach. Different ICDs cause specific zygomatic shape modifications corresponding to different degrees of retrusion but the shape of the zygomatic bone alone is not a sufficient parameter for classifying populations into ICD groups defined by deformation types. We illustrate the fact that external mechanical constraints on the skull vault influence midfacial growth. ICDs are a model for the study of the influence of epigenetic factors on craniofacial growth and can help to understand the facial effects of congenital skull malformations such as single or multi-suture synostoses, or of external orthopedic devices such as helmets used to correct deformational plagiocephaly. © 2016 Anatomical Society.

  7. A point cloud modeling method based on geometric constraints mixing the robust least squares method

    NASA Astrophysics Data System (ADS)

    Yue, JIanping; Pan, Yi; Yue, Shun; Liu, Dapeng; Liu, Bin; Huang, Nan

    2016-10-01

    The appearance of 3D laser scanning technology has provided a new method for the acquisition of spatial 3D information. It has been widely used in the field of Surveying and Mapping Engineering with the characteristics of automatic and high precision. 3D laser scanning data processing process mainly includes the external laser data acquisition, the internal industry laser data splicing, the late 3D modeling and data integration system. For the point cloud modeling, domestic and foreign researchers have done a lot of research. Surface reconstruction technology mainly include the point shape, the triangle model, the triangle Bezier surface model, the rectangular surface model and so on, and the neural network and the Alfa shape are also used in the curved surface reconstruction. But in these methods, it is often focused on single surface fitting, automatic or manual block fitting, which ignores the model's integrity. It leads to a serious problems in the model after stitching, that is, the surfaces fitting separately is often not satisfied with the well-known geometric constraints, such as parallel, vertical, a fixed angle, or a fixed distance. However, the research on the special modeling theory such as the dimension constraint and the position constraint is not used widely. One of the traditional modeling methods adding geometric constraints is a method combing the penalty function method and the Levenberg-Marquardt algorithm (L-M algorithm), whose stability is pretty good. But in the research process, it is found that the method is greatly influenced by the initial value. In this paper, we propose an improved method of point cloud model taking into account the geometric constraint. We first apply robust least-squares to enhance the initial value's accuracy, and then use penalty function method to transform constrained optimization problems into unconstrained optimization problems, and finally solve the problems using the L-M algorithm. The experimental results show that the internal accuracy is improved, and it is shown that the improved method for point clouds modeling proposed by this paper outperforms the traditional point clouds modeling methods.

  8. Task Assignment and Path Planning for Multiple Autonomous Underwater Vehicles Using 3D Dubins Curves †

    PubMed Central

    Zhang, Meiyan; Zheng, Yahong Rosa

    2017-01-01

    This paper investigates the task assignment and path planning problem for multiple AUVs in three dimensional (3D) underwater wireless sensor networks where nonholonomic motion constraints of underwater AUVs in 3D space are considered. The multi-target task assignment and path planning problem is modeled by the Multiple Traveling Sales Person (MTSP) problem and the Genetic Algorithm (GA) is used to solve the MTSP problem with Euclidean distance as the cost function and the Tour Hop Balance (THB) or Tour Length Balance (TLB) constraints as the stop criterion. The resulting tour sequences are mapped to 2D Dubins curves in the X−Y plane, and then interpolated linearly to obtain the Z coordinates. We demonstrate that the linear interpolation fails to achieve G1 continuity in the 3D Dubins path for multiple targets. Therefore, the interpolated 3D Dubins curves are checked against the AUV dynamics constraint and the ones satisfying the constraint are accepted to finalize the 3D Dubins curve selection. Simulation results demonstrate that the integration of the 3D Dubins curve with the MTSP model is successful and effective for solving the 3D target assignment and path planning problem. PMID:28696377

  9. Task Assignment and Path Planning for Multiple Autonomous Underwater Vehicles Using 3D Dubins Curves †.

    PubMed

    Cai, Wenyu; Zhang, Meiyan; Zheng, Yahong Rosa

    2017-07-11

    This paper investigates the task assignment and path planning problem for multiple AUVs in three dimensional (3D) underwater wireless sensor networks where nonholonomic motion constraints of underwater AUVs in 3D space are considered. The multi-target task assignment and path planning problem is modeled by the Multiple Traveling Sales Person (MTSP) problem and the Genetic Algorithm (GA) is used to solve the MTSP problem with Euclidean distance as the cost function and the Tour Hop Balance (THB) or Tour Length Balance (TLB) constraints as the stop criterion. The resulting tour sequences are mapped to 2D Dubins curves in the X - Y plane, and then interpolated linearly to obtain the Z coordinates. We demonstrate that the linear interpolation fails to achieve G 1 continuity in the 3D Dubins path for multiple targets. Therefore, the interpolated 3D Dubins curves are checked against the AUV dynamics constraint and the ones satisfying the constraint are accepted to finalize the 3D Dubins curve selection. Simulation results demonstrate that the integration of the 3D Dubins curve with the MTSP model is successful and effective for solving the 3D target assignment and path planning problem.

  10. Is there room for C P violation in the top-Higgs sector?

    DOE PAGES

    Cirigliano, Vincenzo; Dekens, Wouter Gerard; de Vries, Jordy; ...

    2016-07-21

    Here, we discuss direct and indirect probes of chirality-flipping couplings of the top quark to Higgs and gauge bosons, considering both CP-conserving and CP-violating observables, in the framework of the Standard Model effective field theory. In our analysis we include current and prospective constraints from collider physics, precision electroweak tests, flavor physics, and electric dipole moments (EDMs). We find that low-energy indirect probes are very competitive, even after accounting for long-distance uncertainties. In particular, EDMs put constraints on the electroweak CP-violating dipole moments of the top that are 2 to 3 orders of magnitude stronger than existing limits. The newmore » indirect constraint on the top EDM is given by |d t| < 5×10 –20e cm at 90% C.L.« less

  11. Elucidating ΛCDM: Impact of Baryon Acoustic Oscillation Measurements on the Hubble Constant Discrepancy

    NASA Astrophysics Data System (ADS)

    Addison, G. E.; Watts, D. J.; Bennett, C. L.; Halpern, M.; Hinshaw, G.; Weiland, J. L.

    2018-02-01

    We examine the impact of baryon acoustic oscillation (BAO) scale measurements on the discrepancy between the value of the Hubble constant (H 0) inferred from the local distance ladder and that from Planck cosmic microwave background (CMB) data. While the BAO data alone cannot constrain H 0, we show that combining the latest BAO results with WMAP, Atacama Cosmology Telescope (ACT), or South Pole Telescope (SPT) CMB data produces values of H 0 that are 2.4{--}3.1σ lower than the distance ladder, independent of Planck, and that this downward pull was less apparent in some earlier analyses that used only angle-averaged BAO scale constraints rather than full anisotropic information. At the same time, the combination of BAO and CMB data also disfavors the lower values of H 0 preferred by the Planck high-multipole temperature power spectrum. Combining galaxy and Lyα forest BAO with a precise estimate of the primordial deuterium abundance produces {H}0=66.98+/- 1.18 km s‑1 Mpc‑1 for the flat {{Λ }}{CDM} model. This value is completely independent of CMB anisotropy constraints and is 3.0σ lower than the latest distance ladder constraint, although 2.4σ tension also exists between the galaxy BAO and Lyα BAO. These results show that it is not possible to explain the H 0 disagreement solely with a systematic error specific to the Planck data. The fact that tensions remain even after the removal of any single data set makes this intriguing puzzle all the more challenging to resolve.

  12. Exact geodesic distances in FLRW spacetimes

    NASA Astrophysics Data System (ADS)

    Cunningham, William J.; Rideout, David; Halverson, James; Krioukov, Dmitri

    2017-11-01

    Geodesics are used in a wide array of applications in cosmology and astrophysics. However, it is not a trivial task to efficiently calculate exact geodesic distances in an arbitrary spacetime. We show that in spatially flat (3 +1 )-dimensional Friedmann-Lemaître-Robertson-Walker (FLRW) spacetimes, it is possible to integrate the second-order geodesic differential equations, and derive a general method for finding both timelike and spacelike distances given initial-value or boundary-value constraints. In flat spacetimes with either dark energy or matter, whether dust, radiation, or a stiff fluid, we find an exact closed-form solution for geodesic distances. In spacetimes with a mixture of dark energy and matter, including spacetimes used to model our physical universe, there exists no closed-form solution, but we provide a fast numerical method to compute geodesics. A general method is also described for determining the geodesic connectedness of an FLRW manifold, provided only its scale factor.

  13. Model independent constraints on transition redshift

    NASA Astrophysics Data System (ADS)

    Jesus, J. F.; Holanda, R. F. L.; Pereira, S. H.

    2018-05-01

    This paper aims to put constraints on the transition redshift zt, which determines the onset of cosmic acceleration, in cosmological-model independent frameworks. In order to perform our analyses, we consider a flat universe and assume a parametrization for the comoving distance DC(z) up to third degree on z, a second degree parametrization for the Hubble parameter H(z) and a linear parametrization for the deceleration parameter q(z). For each case, we show that type Ia supernovae and H(z) data complement each other on the parameter space and tighter constrains for the transition redshift are obtained. By combining the type Ia supernovae observations and Hubble parameter measurements it is possible to constrain the values of zt, for each approach, as 0.806± 0.094, 0.870± 0.063 and 0.973± 0.058 at 1σ c.l., respectively. Then, such approaches provide cosmological-model independent estimates for this parameter.

  14. Analysis of regional total factor energy efficiency in China under environmental constraints: based on undesirable-minds and DEA window model

    NASA Astrophysics Data System (ADS)

    Zhang, Shuying; Li, Deshan; Li, Shuangqiang; Jiang, Hanyu; Shen, Yuqing

    2017-06-01

    With China’s entrance into the new economy, the improvement of energy efficiency has become an important indicator to measure the quality of ecological civilization construction and economic development. According to the panel data of Chinese regions in 1996-2014, the nearest distance to the efficient frontier of Undesirable-MinDS Xeon model and DEA window model have been used to calculate the total factor energy efficiency of China’s regions. Study found that: Under environmental constraints, China’s total factor energy efficiency has increased after the first drop in the overall 1996-2014, and then increases again. And the difference between the regions is very large, showing a characteristic of “the east is the highest, the west is lower, and lowest is in the central” finally, this paper puts forward relevant policy suggestions.

  15. The neutron star in HESS J1731-347: Central compact objects as laboratories to study the equation of state of superdense matter

    NASA Astrophysics Data System (ADS)

    Klochkov, D.; Suleimanov, V.; Pühlhofer, G.; Yakovlev, D. G.; Santangelo, A.; Werner, K.

    2015-01-01

    Context. Central compact objects (CCOs) in supernova remnants are isolated thermally emitting neutron stars (NSs). They are most probably characterized by a magnetic field strength that is roughly two orders of magnitude lower than that of most of the radio and accreting pulsars. The thermal emission of CCOs can be modeled to obtain constraints on the physical parameters of the star such as its mass, radius, effective temperature, and chemical composition. Aims: The CCO in HESS J1731-347 is one of the brightest objects in this class. Starting from 2007, it was observed several times with different X-ray satellites. Here we present our analysis of two new XMM-Newton observations of the source performed in 2013 which increase the total exposure time of the data available for spectral analysis by a factor of about five compared to the analyses presented before. Methods: We use our numerical spectral models for carbon and hydrogen atmospheres to fit the spectrum of the CCO. From our fits, we derive constraints on the physical parameters of the emitting star such as its mass, radius, distance, and effective temperature. We also use the new data to derive new upper limits on the source pulsations and to confirm the absence of a long-term flux and spectral variability. Results: The analysis shows that atmosphere models are clearly preferred by the fit over the blackbody spectral function. Under the assumption that the X-ray emission is uniformly produced by the entire star surface (supported by the lack of pulsations), hydrogen atmosphere models lead to uncomfortably large distances of the CCO, above 7-8 kpc. On the other hand, the carbon atmosphere model formally excludes distances above 5-6 kpc and is compatible with the source located in the Scutum-Crux (~3 kpc) or Norma-Cygnus (~4.5 kpc) Galactic spiral arm. We provide and discuss the corresponding confidence contours in the NS mass-radius plane. The measured effective temperature indicates that the NS is exceptionally hot for the estimated age of ~30 kyr. We discuss possible cooling scenarios to explain this property, as well as possible additional constraints on the star mass and radius from cooling theory.

  16. Measurement of the phase difference between short- and long-distance amplitudes in the {{B} ^+} → {{{K}} ^+} {μ ^+μ ^-} decay

    NASA Astrophysics Data System (ADS)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Andreassi, G.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Archilli, F.; d'Argent, P.; Arnau Romeu, J.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Babuschkin, I.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baker, S.; Balagura, V.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Baszczyk, M.; Batozskaya, V.; Batsukh, B.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Bel, L. J.; Bellee, V.; Belloli, N.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Betancourt, C.; Betti, F.; Bettler, M.-O.; van Beuzekom, M.; Bezshyiko, Ia.; Bifani, S.; Billoir, P.; Bird, T.; Birnkraut, A.; Bitadze, A.; Bizzeti, A.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Boettcher, T.; Bondar, A.; Bondar, N.; Bonivento, W.; Bordyuzhin, I.; Borgheresi, A.; Borghi, S.; Borisyak, M.; Borsato, M.; Bossu, F.; Boubdir, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Braun, S.; Britsch, M.; Britton, T.; Brodzicka, J.; Buchanan, E.; Burr, C.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D. H.; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Castillo Garcia, L.; Cattaneo, M.; Cavallero, G.; Cenci, R.; Chamont, D.; Charles, M.; Charpentier, Ph.; Chatzikonstantinidis, G.; Chefdeville, M.; Chen, S.; Cheung, S.-F.; Chobanova, V.; Chrzaszcz, M.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombs, G.; Coquereau, S.; Corti, G.; Corvo, M.; Costa Sobral, C. M.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Da Cunha Marinho, F.; Dall'Occo, E.; Dalseno, J.; David, P. N. Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Serio, M.; De Simone, P.; Dean, C.-T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Demmer, M.; Dendek, A.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Dijkstra, H.; Dordei, F.; Dorigo, M.; Dosil Suárez, A.; Dovbnya, A.; Dreimanis, K.; Dufour, L.; Dujany, G.; Dungs, K.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Déléage, N.; Easo, S.; Ebert, M.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Farley, N.; Farry, S.; Fay, R.; Fazzini, D.; Ferguson, D.; Fernandez Prieto, A.; Ferrari, F.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fini, R. A.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fleuret, F.; Fohl, K.; Fontana, M.; Fontanelli, F.; Forshaw, D. C.; Forty, R.; Franco Lima, V.; Frank, M.; Frei, C.; Fu, J.; Funk, W.; Furfaro, E.; Färber, C.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; Garcia Martin, L. M.; García Pardiñas, J.; Garra Tico, J.; Garrido, L.; Garsed, P. J.; Gascon, D.; Gaspar, C.; Gavardi, L.; Gazzoni, G.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianì, S.; Gibson, V.; Girard, O. G.; Giubega, L.; Gizdov, K.; Gligorov, V. V.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gorelov, I. V.; Gotti, C.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graverini, E.; Graziani, G.; Grecu, A.; Griffith, P.; Grillo, L.; Gruberg Cazon, B. R.; Grünberg, O.; Gushchin, E.; Guz, Yu.; Gys, T.; Göbel, C.; Hadavizadeh, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; Hatch, M.; He, J.; Head, T.; Heister, A.; Hennessy, K.; Henrard, P.; Henry, L.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hombach, C.; Hopchev, H.; Hulsbergen, W.; Humair, T.; Hushchyn, M.; Hutchcroft, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jawahery, A.; Jiang, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Karacson, M.; Kariuki, J. M.; Karodia, S.; Kecke, M.; Kelsey, M.; Kenzie, M.; Ketel, T.; Khairullin, E.; Khanji, B.; Khurewathanakul, C.; Kirn, T.; Klaver, S.; Klimaszewski, K.; Koliiev, S.; Kolpin, M.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Kosmyntseva, A.; Kozachuk, A.; Kozeiha, M.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krokovny, P.; Kruse, F.; Krzemien, W.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kuonen, A. K.; Kurek, K.; Kvaratskheliya, T.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lanfranchi, G.; Langenbruch, C.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Leflat, A.; Lefrançois, J.; Lefèvre, R.; Lemaitre, F.; Lemos Cid, E.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, T.; Li, Y.; Likhomanenko, T.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, X.; Loh, D.; Longstaff, I.; Lopes, J. H.; Lucchesi, D.; Lucio Martinez, M.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Lusiani, A.; Lyu, X.; Machefert, F.; Maciuc, F.; Maev, O.; Maguire, K.; Malde, S.; Malinin, A.; Maltsev, T.; Manca, G.; Mancinelli, G.; Manning, P.; Maratas, J.; Marchand, J. F.; Marconi, U.; Marin Benito, C.; Marinangeli, M.; Marino, P.; Marks, J.; Martellotti, G.; Martin, M.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massacrier, L. M.; Massafferri, A.; Matev, R.; Mathad, A.; Mathe, Z.; Matteuzzi, C.; Mauri, A.; Maurice, E.; Maurin, B.; Mazurov, A.; McCann, M.; McNab, A.; McNulty, R.; Meadows, B.; Meier, F.; Meissner, M.; Melnychuk, D.; Merk, M.; Merli, A.; Michielin, E.; Milanes, D. A.; Minard, M.-N.; Mitzel, D. S.; Mogini, A.; Molina Rodriguez, J.; Monroy, I. A.; Monteil, S.; Morandin, M.; Morawski, P.; Mordà, A.; Morello, M. J.; Morgunova, O.; Moron, J.; Morris, A. B.; Mountain, R.; Muheim, F.; Mulder, M.; Mussini, M.; Müller, D.; Müller, J.; Müller, K.; Müller, V.; Naik, P.; Nakada, T.; Nandakumar, R.; Nandi, A.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, T. D.; Nguyen-Mau, C.; Nieswand, S.; Niet, R.; Nikitin, N.; Nikodem, T.; Nogay, A.; Novoselov, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Ogilvy, S.; Oldeman, R.; Onderwater, C. J. G.; Otalora Goicochea, J. M.; Otto, A.; Owen, P.; Oyanguren, A.; Pais, P. R.; Palano, A.; Palombo, F.; Palutan, M.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Parker, W.; Parkes, C.; Passaleva, G.; Pastore, A.; Patel, G. D.; Patel, M.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perret, P.; Pescatore, L.; Petridis, K.; Petrolini, A.; Petrov, A.; Petruzzo, M.; Picatoste Olloqui, E.; Pietrzyk, B.; Pikies, M.; Pinci, D.; Pistone, A.; Piucci, A.; Placinta, V.; Playfer, S.; Plo Casasus, M.; Poikela, T.; Polci, F.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Pomery, G. J.; Popov, A.; Popov, D.; Popovici, B.; Poslavskii, S.; Potterat, C.; Price, E.; Price, J. D.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Quagliani, R.; Rachwal, B.; Rademacker, J. H.; Rama, M.; Ramos Pernas, M.; Rangel, M. S.; Raniuk, I.; Ratnikov, F.; Raven, G.; Redi, F.; Reichert, S.; dos Reis, A. C.; Remon Alepuz, C.; Renaudin, V.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Robbe, P.; Rodrigues, A. B.; Rodrigues, E.; Rodriguez Lopez, J. A.; Rodriguez Perez, P.; Rogozhnikov, A.; Roiser, S.; Rollings, A.; Romanovskiy, V.; Romero Vidal, A.; Ronayne, J. W.; Rotondo, M.; Rudolph, M. S.; Ruf, T.; Ruiz Valls, P.; Saborido Silva, J. J.; Sadykhov, E.; Sagidova, N.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santimaria, M.; Santovetti, E.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schael, S.; Schellenberg, M.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmelzer, T.; Schmidt, B.; Schneider, O.; Schopper, A.; Schubert, K.; Schubiger, M.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sergi, A.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Siddi, B. G.; Silva Coutinho, R.; Silva de Oliveira, L.; Simi, G.; Simone, S.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, E.; Smith, I. T.; Smith, J.; Smith, M.; Snoek, H.; Soares Lavra, l.; Sokoloff, M. D.; Soler, F. J. P.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, S.; Stefko, P.; Stefkova, S.; Steinkamp, O.; Stemmle, S.; Stenyakin, O.; Stevens, H.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Sun, L.; Sutcliffe, W.; Swientek, K.; Syropoulos, V.; Szczekowski, M.; Szumlak, T.; T'Jampens, S.; Tayduganov, A.; Tekampe, T.; Tellarini, G.; Teubert, F.; Thomas, E.; van Tilburg, J.; Tilley, M. J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Toriello, F.; Tournefier, E.; Tourneur, S.; Trabelsi, K.; Traill, M.; Tran, M. T.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tully, A.; Tuning, N.; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagnoni, V.; Valassi, A.; Valat, S.; Valenti, G.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vecchi, S.; van Veghel, M.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Venkateswaran, A.; Vernet, M.; Vesterinen, M.; Viana Barbosa, J. V.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Viemann, H.; Vilasis-Cardona, X.; Vitti, M.; Volkov, V.; Vollhardt, A.; Voneki, B.; Vorobyev, A.; Vorobyev, V.; Voß, C.; de Vries, J. A.; Vázquez Sierra, C.; Waldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wang, J.; Ward, D. R.; Wark, H. M.; Watson, N. K.; Websdale, D.; Weiden, A.; Whitehead, M.; Wicht, J.; Wilkinson, G.; Wilkinson, M.; Williams, M.; Williams, M. P.; Williams, M.; Williams, T.; Wilson, F. F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wraight, K.; Wyllie, K.; Xie, Y.; Xing, Z.; Xu, Z.; Yang, Z.; Yao, Y.; Yin, H.; Yu, J.; Yuan, X.; Yushchenko, O.; Zarebski, K. A.; Zavertyaev, M.; Zhang, L.; Zhang, Y.; Zhang, Y.; Zhelezov, A.; Zheng, Y.; Zhu, X.; Zhukov, V.; Zucchelli, S.

    2017-03-01

    A measurement of the phase difference between the short- and long-distance contributions to the {{B} ^+} → {{{K}} ^+} {μ ^+μ ^-} decay is performed by analysing the dimuon mass distribution. The analysis is based on pp collision data corresponding to an integrated luminosity of 3 fb^{-1} collected by the LHCb experiment in 2011 and 2012. The long-distance contribution to the {{B} ^+} → {{{K}} ^+} {μ ^+μ ^-} decay is modelled as a sum of relativistic Breit-Wigner amplitudes representing different vector meson resonances decaying to muon pairs, each with their own magnitude and phase. The measured phases of the {{J}/ψ } and ψ {(2S)} resonances are such that the interference with the short-distance component in dimuon mass regions far from their pole masses is small. In addition, constraints are placed on the Wilson coefficients, C9 and C_{10}, and the branching fraction of the short-distance component is measured.

  17. Measurement of the phase difference between short- and long-distance amplitudes in the [Formula: see text] decay.

    PubMed

    Aaij, R; Adeva, B; Adinolfi, M; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Andreassi, G; Andreotti, M; Andrews, J E; Appleby, R B; Archilli, F; d'Argent, P; Arnau Romeu, J; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Babuschkin, I; Bachmann, S; Back, J J; Badalov, A; Baesso, C; Baker, S; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Baszczyk, M; Batozskaya, V; Batsukh, B; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Bel, L J; Bellee, V; Belloli, N; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Berezhnoy, A; Bernet, R; Bertolin, A; Betancourt, C; Betti, F; Bettler, M-O; van Beuzekom, M; Bezshyiko, Ia; Bifani, S; Billoir, P; Bird, T; Birnkraut, A; Bitadze, A; Bizzeti, A; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Boettcher, T; Bondar, A; Bondar, N; Bonivento, W; Bordyuzhin, I; Borgheresi, A; Borghi, S; Borisyak, M; Borsato, M; Bossu, F; Boubdir, M; Bowcock, T J V; Bowen, E; Bozzi, C; Braun, S; Britsch, M; Britton, T; Brodzicka, J; Buchanan, E; Burr, C; Bursche, A; Buytaert, J; Cadeddu, S; Calabrese, R; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Campora Perez, D H; Capriotti, L; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carniti, P; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Castillo Garcia, L; Cattaneo, M; Cavallero, G; Cenci, R; Chamont, D; Charles, M; Charpentier, Ph; Chatzikonstantinidis, G; Chefdeville, M; Chen, S; Cheung, S-F; Chobanova, V; Chrzaszcz, M; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coco, V; Cogan, J; Cogneras, E; Cogoni, V; Cojocariu, L; Collazuol, G; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombs, G; Coquereau, S; Corti, G; Corvo, M; Costa Sobral, C M; Couturier, B; Cowan, G A; Craik, D C; Crocombe, A; Cruz Torres, M; Cunliffe, S; Currie, R; D'Ambrosio, C; Da Cunha Marinho, F; Dall'Occo, E; Dalseno, J; David, P N Y; Davis, A; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Serio, M; De Simone, P; Dean, C-T; Decamp, D; Deckenhoff, M; Del Buono, L; Demmer, M; Dendek, A; Derkach, D; Deschamps, O; Dettori, F; Dey, B; Di Canto, A; Dijkstra, H; Dordei, F; Dorigo, M; Dosil Suárez, A; Dovbnya, A; Dreimanis, K; Dufour, L; Dujany, G; Dungs, K; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Déléage, N; Easo, S; Ebert, M; Egede, U; Egorychev, V; Eidelman, S; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; Ely, S; Esen, S; Evans, H M; Evans, T; Falabella, A; Farley, N; Farry, S; Fay, R; Fazzini, D; Ferguson, D; Fernandez Prieto, A; Ferrari, F; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fini, R A; Fiore, M; Fiorini, M; Firlej, M; Fitzpatrick, C; Fiutowski, T; Fleuret, F; Fohl, K; Fontana, M; Fontanelli, F; Forshaw, D C; Forty, R; Franco Lima, V; Frank, M; Frei, C; Fu, J; Funk, W; Furfaro, E; Färber, C; Gallas Torreira, A; Galli, D; Gallorini, S; Gambetta, S; Gandelman, M; Gandini, P; Gao, Y; Garcia Martin, L M; García Pardiñas, J; Garra Tico, J; Garrido, L; Garsed, P J; Gascon, D; Gaspar, C; Gavardi, L; Gazzoni, G; Gerick, D; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gianì, S; Gibson, V; Girard, O G; Giubega, L; Gizdov, K; Gligorov, V V; Golubkov, D; Golutvin, A; Gomes, A; Gorelov, I V; Gotti, C; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graverini, E; Graziani, G; Grecu, A; Griffith, P; Grillo, L; Gruberg Cazon, B R; Grünberg, O; Gushchin, E; Guz, Yu; Gys, T; Göbel, C; Hadavizadeh, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Han, X; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hatch, M; He, J; Head, T; Heister, A; Hennessy, K; Henrard, P; Henry, L; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hombach, C; Hopchev, H; Hulsbergen, W; Humair, T; Hushchyn, M; Hutchcroft, D; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jalocha, J; Jans, E; Jawahery, A; Jiang, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kandybei, S; Karacson, M; Kariuki, J M; Karodia, S; Kecke, M; Kelsey, M; Kenzie, M; Ketel, T; Khairullin, E; Khanji, B; Khurewathanakul, C; Kirn, T; Klaver, S; Klimaszewski, K; Koliiev, S; Kolpin, M; Komarov, I; Koopman, R F; Koppenburg, P; Kosmyntseva, A; Kozachuk, A; Kozeiha, M; Kravchuk, L; Kreplin, K; Kreps, M; Krokovny, P; Kruse, F; Krzemien, W; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kuonen, A K; Kurek, K; Kvaratskheliya, T; Lacarrere, D; Lafferty, G; Lai, A; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Leflat, A; Lefrançois, J; Lefèvre, R; Lemaitre, F; Lemos Cid, E; Leroy, O; Lesiak, T; Leverington, B; Li, T; Li, Y; Likhomanenko, T; Lindner, R; Linn, C; Lionetto, F; Liu, X; Loh, D; Longstaff, I; Lopes, J H; Lucchesi, D; Lucio Martinez, M; Luo, H; Lupato, A; Luppi, E; Lupton, O; Lusiani, A; Lyu, X; Machefert, F; Maciuc, F; Maev, O; Maguire, K; Malde, S; Malinin, A; Maltsev, T; Manca, G; Mancinelli, G; Manning, P; Maratas, J; Marchand, J F; Marconi, U; Marin Benito, C; Marinangeli, M; Marino, P; Marks, J; Martellotti, G; Martin, M; Martinelli, M; Martinez Santos, D; Martinez Vidal, F; Martins Tostes, D; Massacrier, L M; Massafferri, A; Matev, R; Mathad, A; Mathe, Z; Matteuzzi, C; Mauri, A; Maurice, E; Maurin, B; Mazurov, A; McCann, M; McNab, A; McNulty, R; Meadows, B; Meier, F; Meissner, M; Melnychuk, D; Merk, M; Merli, A; Michielin, E; Milanes, D A; Minard, M-N; Mitzel, D S; Mogini, A; Molina Rodriguez, J; Monroy, I A; Monteil, S; Morandin, M; Morawski, P; Mordà, A; Morello, M J; Morgunova, O; Moron, J; Morris, A B; Mountain, R; Muheim, F; Mulder, M; Mussini, M; Müller, D; Müller, J; Müller, K; Müller, V; Naik, P; Nakada, T; Nandakumar, R; Nandi, A; Nasteva, I; Needham, M; Neri, N; Neubert, S; Neufeld, N; Neuner, M; Nguyen, T D; Nguyen-Mau, C; Nieswand, S; Niet, R; Nikitin, N; Nikodem, T; Nogay, A; Novoselov, A; O'Hanlon, D P; Oblakowska-Mucha, A; Obraztsov, V; Ogilvy, S; Oldeman, R; Onderwater, C J G; Otalora Goicochea, J M; Otto, A; Owen, P; Oyanguren, A; Pais, P R; Palano, A; Palombo, F; Palutan, M; Papanestis, A; Pappagallo, M; Pappalardo, L L; Parker, W; Parkes, C; Passaleva, G; Pastore, A; Patel, G D; Patel, M; Patrignani, C; Pearce, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perret, P; Pescatore, L; Petridis, K; Petrolini, A; Petrov, A; Petruzzo, M; Picatoste Olloqui, E; Pietrzyk, B; Pikies, M; Pinci, D; Pistone, A; Piucci, A; Placinta, V; Playfer, S; Plo Casasus, M; Poikela, T; Polci, F; Poluektov, A; Polyakov, I; Polycarpo, E; Pomery, G J; Popov, A; Popov, D; Popovici, B; Poslavskii, S; Potterat, C; Price, E; Price, J D; Prisciandaro, J; Pritchard, A; Prouve, C; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Quagliani, R; Rachwal, B; Rademacker, J H; Rama, M; Ramos Pernas, M; Rangel, M S; Raniuk, I; Ratnikov, F; Raven, G; Redi, F; Reichert, S; Dos Reis, A C; Remon Alepuz, C; Renaudin, V; Ricciardi, S; Richards, S; Rihl, M; Rinnert, K; Rives Molina, V; Robbe, P; Rodrigues, A B; Rodrigues, E; Rodriguez Lopez, J A; Rodriguez Perez, P; Rogozhnikov, A; Roiser, S; Rollings, A; Romanovskiy, V; Romero Vidal, A; Ronayne, J W; Rotondo, M; Rudolph, M S; Ruf, T; Ruiz Valls, P; Saborido Silva, J J; Sadykhov, E; Sagidova, N; Saitta, B; Salustino Guimaraes, V; Sanchez Mayordomo, C; Sanmartin Sedes, B; Santacesaria, R; Santamarina Rios, C; Santimaria, M; Santovetti, E; Sarti, A; Satriano, C; Satta, A; Saunders, D M; Savrina, D; Schael, S; Schellenberg, M; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmelzer, T; Schmidt, B; Schneider, O; Schopper, A; Schubert, K; Schubiger, M; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Semennikov, A; Sergi, A; Serra, N; Serrano, J; Sestini, L; Seyfert, P; Shapkin, M; Shapoval, I; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, V; Siddi, B G; Silva Coutinho, R; Silva de Oliveira, L; Simi, G; Simone, S; Sirendi, M; Skidmore, N; Skwarnicki, T; Smith, E; Smith, I T; Smith, J; Smith, M; Snoek, H; Soares Lavra, L; Sokoloff, M D; Soler, F J P; Souza De Paula, B; Spaan, B; Spradlin, P; Sridharan, S; Stagni, F; Stahl, M; Stahl, S; Stefko, P; Stefkova, S; Steinkamp, O; Stemmle, S; Stenyakin, O; Stevens, H; Stevenson, S; Stoica, S; Stone, S; Storaci, B; Stracka, S; Straticiuc, M; Straumann, U; Sun, L; Sutcliffe, W; Swientek, K; Syropoulos, V; Szczekowski, M; Szumlak, T; T'Jampens, S; Tayduganov, A; Tekampe, T; Tellarini, G; Teubert, F; Thomas, E; van Tilburg, J; Tilley, M J; Tisserand, V; Tobin, M; Tolk, S; Tomassetti, L; Tonelli, D; Topp-Joergensen, S; Toriello, F; Tournefier, E; Tourneur, S; Trabelsi, K; Traill, M; Tran, M T; Tresch, M; Trisovic, A; Tsaregorodtsev, A; Tsopelas, P; Tully, A; Tuning, N; Ukleja, A; Ustyuzhanin, A; Uwer, U; Vacca, C; Vagnoni, V; Valassi, A; Valat, S; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; van Veghel, M; Velthuis, J J; Veltri, M; Veneziano, G; Venkateswaran, A; Vernet, M; Vesterinen, M; Viana Barbosa, J V; Viaud, B; Vieira, D; Vieites Diaz, M; Viemann, H; Vilasis-Cardona, X; Vitti, M; Volkov, V; Vollhardt, A; Voneki, B; Vorobyev, A; Vorobyev, V; Voß, C; de Vries, J A; Vázquez Sierra, C; Waldi, R; Wallace, C; Wallace, R; Walsh, J; Wang, J; Ward, D R; Wark, H M; Watson, N K; Websdale, D; Weiden, A; Whitehead, M; Wicht, J; Wilkinson, G; Wilkinson, M; Williams, M; Williams, M P; Williams, M; Williams, T; Wilson, F F; Wimberley, J; Wishahi, J; Wislicki, W; Witek, M; Wormser, G; Wotton, S A; Wraight, K; Wyllie, K; Xie, Y; Xing, Z; Xu, Z; Yang, Z; Yao, Y; Yin, H; Yu, J; Yuan, X; Yushchenko, O; Zarebski, K A; Zavertyaev, M; Zhang, L; Zhang, Y; Zhang, Y; Zhelezov, A; Zheng, Y; Zhu, X; Zhukov, V; Zucchelli, S

    2017-01-01

    A measurement of the phase difference between the short- and long-distance contributions to the [Formula: see text] decay is performed by analysing the dimuon mass distribution. The analysis is based on pp collision data corresponding to an integrated luminosity of 3[Formula: see text] collected by the LHCb experiment in 2011 and 2012. The long-distance contribution to the [Formula: see text] decay is modelled as a sum of relativistic Breit-Wigner amplitudes representing different vector meson resonances decaying to muon pairs, each with their own magnitude and phase. The measured phases of the [Formula: see text] and [Formula: see text] resonances are such that the interference with the short-distance component in dimuon mass regions far from their pole masses is small. In addition, constraints are placed on the Wilson coefficients, [Formula: see text] and [Formula: see text], and the branching fraction of the short-distance component is measured.

  18. A marked correlation function for constraining modified gravity models

    NASA Astrophysics Data System (ADS)

    White, Martin

    2016-11-01

    Future large scale structure surveys will provide increasingly tight constraints on our cosmological model. These surveys will report results on the distance scale and growth rate of perturbations through measurements of Baryon Acoustic Oscillations and Redshift-Space Distortions. It is interesting to ask: what further analyses should become routine, so as to test as-yet-unknown models of cosmic acceleration? Models which aim to explain the accelerated expansion rate of the Universe by modifications to General Relativity often invoke screening mechanisms which can imprint a non-standard density dependence on their predictions. This suggests density-dependent clustering as a `generic' constraint. This paper argues that a density-marked correlation function provides a density-dependent statistic which is easy to compute and report and requires minimal additional infrastructure beyond what is routinely available to such survey analyses. We give one realization of this idea and study it using low order perturbation theory. We encourage groups developing modified gravity theories to see whether such statistics provide discriminatory power for their models.

  19. Probabilistic determination of probe locations from distance data

    PubMed Central

    Xu, Xiao-Ping; Slaughter, Brian D.; Volkmann, Niels

    2013-01-01

    Distance constraints, in principle, can be employed to determine information about the location of probes within a three-dimensional volume. Traditional methods for locating probes from distance constraints involve optimization of scoring functions that measure how well the probe location fits the distance data, exploring only a small subset of the scoring function landscape in the process. These methods are not guaranteed to find the global optimum and provide no means to relate the identified optimum to all other optima in scoring space. Here, we introduce a method for the location of probes from distance information that is based on probability calculus. This method allows exploration of the entire scoring space by directly combining probability functions representing the distance data and information about attachment sites. The approach is guaranteed to identify the global optimum and enables the derivation of confidence intervals for the probe location as well as statistical quantification of ambiguities. We apply the method to determine the location of a fluorescence probe using distances derived by FRET and show that the resulting location matches that independently derived by electron microscopy. PMID:23770585

  20. Multi-objective trajectory optimization for the space exploration vehicle

    NASA Astrophysics Data System (ADS)

    Qin, Xiaoli; Xiao, Zhen

    2016-07-01

    The research determines temperature-constrained optimal trajectory for the space exploration vehicle by developing an optimal control formulation and solving it using a variable order quadrature collocation method with a Non-linear Programming(NLP) solver. The vehicle is assumed to be the space reconnaissance aircraft that has specified takeoff/landing locations, specified no-fly zones, and specified targets for sensor data collections. A three degree of freedom aircraft model is adapted from previous work and includes flight dynamics, and thermal constraints.Vehicle control is accomplished by controlling angle of attack, roll angle, and propellant mass flow rate. This model is incorporated into an optimal control formulation that includes constraints on both the vehicle and mission parameters, such as avoidance of no-fly zones and exploration of space targets. In addition, the vehicle models include the environmental models(gravity and atmosphere). How these models are appropriately employed is key to gaining confidence in the results and conclusions of the research. Optimal trajectories are developed using several performance costs in the optimal control formation,minimum time,minimum time with control penalties,and maximum distance.The resulting analysis demonstrates that optimal trajectories that meet specified mission parameters and constraints can be quickly determined and used for large-scale space exloration.

  1. Constraints on pulsed emission model for repeating FRB 121102

    NASA Astrophysics Data System (ADS)

    Kisaka, Shota; Enoto, Teruaki; Shibata, Shinpei

    2017-12-01

    Recent localization of the repeating fast radio burst (FRB) 121102 revealed the distance of its host galaxy and luminosities of the bursts. We investigated constraints on the young neutron star (NS) model, that (a) the FRB intrinsic luminosity is supported by the spin-down energy, and (b) the FRB duration is shorter than the NS rotation period. In the case of a circular cone emission geometry, conditions (a) and (b) determine the NS parameters within very small ranges, compared with that from only condition (a) discussed in previous works. Anisotropy of the pulsed emission does not affect the area of the allowed parameter region by virtue of condition (b). The determined parameters are consistent with those independently limited by the properties of the possible persistent radio counterpart and the circumburst environments such as surrounding materials. Since the NS in the allowed parameter region is older than the spin-down timescale, the hypothetical GRP (giant radio pulse)-like model expects a rapid radio flux decay of ≲1 Jy within a few years as the spin-down luminosity decreases. The continuous monitoring will provide constraints on the young NS models. If no flux evolution is seen, we need to consider an alternative model, e.g., the magnetically powered flare.

  2. Dynamic Parameters of the 2015 Nepal Gorkha Mw7.8 Earthquake Constrained by Multi-observations

    NASA Astrophysics Data System (ADS)

    Weng, H.; Yang, H.

    2017-12-01

    Dynamic rupture model can provide much detailed insights into rupture physics that is capable of assessing future seismic risk. Many studies have attempted to constrain the slip-weakening distance, an important parameter controlling friction behavior of rock, for several earthquakes based on dynamic models, kinematic models, and direct estimations from near-field ground motion. However, large uncertainties of the values of the slip-weakening distance still remain, mostly because of the intrinsic trade-offs between the slip-weakening distance and fault strength. Here we use a spontaneously dynamic rupture model to constrain the frictional parameters of the 25 April 2015 Mw7.8 Nepal earthquake, by combining with multiple seismic observations such as high-rate cGPS data, strong motion data, and kinematic source models. With numerous tests we find the trade-off patterns of final slip, rupture speed, static GPS ground displacements, and dynamic ground waveforms are quite different. Combining all the seismic constraints we can conclude a robust solution without a substantial trade-off of average slip-weakening distance, 0.6 m, in contrast to previous kinematical estimation of 5 m. To our best knowledge, this is the first time to robustly determine the slip-weakening distance on seismogenic fault from seismic observations. The well-constrained frictional parameters may be used for future dynamic models to assess seismic hazard, such as estimating the peak ground acceleration (PGA) etc. Similar approach could also be conducted for other great earthquakes, enabling broad estimations of the dynamic parameters in global perspectives that can better reveal the intrinsic physics of earthquakes.

  3. The WiggleZ Dark Energy Survey: testing the cosmological model with baryon acoustic oscillations at z= 0.6

    NASA Astrophysics Data System (ADS)

    Blake, Chris; Davis, Tamara; Poole, Gregory B.; Parkinson, David; Brough, Sarah; Colless, Matthew; Contreras, Carlos; Couch, Warrick; Croom, Scott; Drinkwater, Michael J.; Forster, Karl; Gilbank, David; Gladders, Mike; Glazebrook, Karl; Jelliffe, Ben; Jurek, Russell J.; Li, I.-Hui; Madore, Barry; Martin, D. Christopher; Pimbblet, Kevin; Pracy, Michael; Sharp, Rob; Wisnioski, Emily; Woods, David; Wyder, Ted K.; Yee, H. K. C.

    2011-08-01

    We measure the imprint of baryon acoustic oscillations (BAOs) in the galaxy clustering pattern at the highest redshift achieved to date, z= 0.6, using the distribution of N= 132 509 emission-line galaxies in the WiggleZ Dark Energy Survey. We quantify BAOs using three statistics: the galaxy correlation function, power spectrum and the band-filtered estimator introduced by Xu et al. The results are mutually consistent, corresponding to a 4.0 per cent measurement of the cosmic distance-redshift relation at z= 0.6 [in terms of the acoustic parameter 'A(z)' introduced by Eisenstein et al., we find A(z= 0.6) = 0.452 ± 0.018]. Both BAOs and power spectrum shape information contribute towards these constraints. The statistical significance of the detection of the acoustic peak in the correlation function, relative to a wiggle-free model, is 3.2σ. The ratios of our distance measurements to those obtained using BAOs in the distribution of luminous red galaxies at redshifts z= 0.2 and 0.35 are consistent with a flat Λ cold dark matter model that also provides a good fit to the pattern of observed fluctuations in the cosmic microwave background radiation. The addition of the current WiggleZ data results in a ≈30 per cent improvement in the measurement accuracy of a constant equation of state, w, using BAO data alone. Based solely on geometric BAO distance ratios, accelerating expansion (w < -1/3) is required with a probability of 99.8 per cent, providing a consistency check of conclusions based on supernovae observations. Further improvements in cosmological constraints will result when the WiggleZ survey data set is complete.

  4. Quality Content in Distance Education

    ERIC Educational Resources Information Center

    Yildiz, Ezgi Pelin; Isman, Aytekin

    2016-01-01

    In parallel with technological advances in today's world of education activities can be conducted without the constraints of time and space. One of the most important of these activities is distance education. The success of the distance education is possible with content quality. The proliferation of e-learning environment has brought a need for…

  5. Spherical cows in the sky with fab four

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kaloper, Nemanja; Sandora, McCullen, E-mail: kaloper@physics.ucdavis.edu, E-mail: mesandora@ucdavis.edu

    2014-05-01

    We explore spherically symmetric static solutions in a subclass of unitary scalar-tensor theories of gravity, called the 'Fab Four' models. The weak field large distance solutions may be phenomenologically viable, but only if the Gauss-Bonnet term is negligible. Only in this limit will the Vainshtein mechanism work consistently. Further, classical constraints and unitarity bounds constrain the models quite tightly. Nevertheless, in the limits where the range of individual terms at large scales is respectively Kinetic Braiding, Horndeski, and Gauss-Bonnet, the horizon scale effects may occur while the theory satisfies Solar system constraints and, marginally, unitarity bounds. On the other hand,more » to bring the cutoff down to below a millimeter constrains all the couplings scales such that 'Fab Fours' can't be heard outside of the Solar system.« less

  6. New observational constraints on f ( R ) gravity from cosmic chronometers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nunes, Rafael C.; Pan, Supriya; Saridakis, Emmanuel N.

    We use the recently released cosmic chronometer data and the latest measured value of the local Hubble parameter, combined with the latest joint light curves of Supernovae Type Ia, and Baryon Acoustic Oscillation distance measurements, in order to impose constraints on the viable and most used f ( R ) gravity models. We consider four f ( R ) models, namely the Hu-Sawicki, the Starobinsky, the Tsujikawa, and the exponential one, and we parametrize them introducing a distortion parameter b that quantifies the deviation from ΛCDM cosmology. Our analysis reveals that a small but non-zero deviation from ΛCDM cosmology ismore » slightly favored, with the corresponding fittings exhibiting very efficient AIC and BIC Information Criteria values. Clearly, f ( R ) gravity is consistent with observations, and it can serve as a candidate for modified gravity.« less

  7. Efficient generation of low-energy folded states of a model protein

    NASA Astrophysics Data System (ADS)

    Gordon, Heather L.; Kwan, Wai Kei; Gong, Chunhang; Larrass, Stefan; Rothstein, Stuart M.

    2003-01-01

    A number of short simulated annealing runs are performed on a highly-frustrated 46-"residue" off-lattice model protein. We perform, in an iterative fashion, a principal component analysis of the 946 nonbonded interbead distances, followed by two varieties of cluster analyses: hierarchical and k-means clustering. We identify several distinct sets of conformations with reasonably consistent cluster membership. Nonbonded distance constraints are derived for each cluster and are employed within a distance geometry approach to generate many new conformations, previously unidentified by the simulated annealing experiments. Subsequent analyses suggest that these new conformations are members of the parent clusters from which they were generated. Furthermore, several novel, previously unobserved structures with low energy were uncovered, augmenting the ensemble of simulated annealing results, and providing a complete distribution of low-energy states. The computational cost of this approach to generating low-energy conformations is small when compared to the expense of further Monte Carlo simulated annealing runs.

  8. Constraints on Nonlinear and Stochastic Growth Theories for Type 3 Solar Radio Bursts from the Corona to 1 AU

    NASA Technical Reports Server (NTRS)

    Cairns, Iver H.; Robinson, P. A.

    1998-01-01

    Existing, competing theories for coronal and interplanetary type III solar radio bursts appeal to one or more of modulational instability, electrostatic (ES) decay processes, or stochastic growth physics to preserve the electron beam, limit the levels of Langmuir-like waves driven by the beam, and produce wave spectra capable of coupling nonlinearly to generate the observed radio emission. Theoretical constraints exist on the wavenumbers and relative sizes of the wave bandwidth and nonlinear growth rate for which Langmuir waves are subject to modulational instability and the parametric and random phase versions of ES decay. A constraint also exists on whether stochastic growth theory (SGT) is appropriate. These constraints are evaluated here using the beam, plasma, and wave properties (1) observed in specific interplanetary type III sources, (2) predicted nominally for the corona, and (3) predicted at heliocentric distances greater than a few solar radii by power-law models based on interplanetary observations. It is found that the Langmuir waves driven directly by the beam have wavenumbers that are almost always too large for modulational instability but are appropriate to ES decay. Even for waves scattered to lower wavenumbers (by ES decay, for instance), the wave bandwidths are predicted to be too large and the nonlinear growth rates too small for modulational instability to occur for the specific interplanetary events studied or the great majority of Langmuir wave packets in type III sources at arbitrary heliocentric distances. Possible exceptions are for very rare, unusually intense, narrowband wave packets, predominantly close to the Sun, and for the front portion of very fast beams traveling through unusually dilute, cold solar wind plasmas. Similar arguments demonstrate that the ES decay should proceed almost always as a random phase process rather than a parametric process, with similar exceptions. These results imply that it is extremely rare for modulational instability or parametric decay to proceed in type III sources at any heliocentric distance: theories for type III bursts based on modulational instability or parametric decay are therefore not viable in general. In contrast, the constraint on SGT can be satisfied and random phase ES decay can proceed at all heliocentric distances under almost all circumstances. (The contrary circumstances involve unusually slow, broad beams moving through unusually hot regions of the Corona.) The analyses presented here strongly justify extending the existing SGT-based model for interplanetary type III bursts (which includes SGT physics, random phase ES decay, and specific electromagnetic emission mechanisms) into a general theory for type III bursts from the corona to beyond 1 AU. This extended theory enjoys strong theoretical support, explains the characteristics of specific interplanetary type III bursts very well, and can account for the detailed dynamic spectra of type III bursts from the lower corona and solar wind.

  9. Dynamical Constraints on Non-Transiting Planets at Trappist-1

    NASA Astrophysics Data System (ADS)

    Jontof-Hutter, Daniel; Truong, Vinh; Ford, Eric; Robertson, Paul; Terrien, Ryan

    2018-04-01

    The outermost of the seven known planets of Trappist-1 orbits six times closer to its host star than Mercury orbits the sun. The architecture of this system beyond 0.07 AU remains unknown. While the presence of additional planets will ultimately be determined by observations, in the meantime, some constraints can be derived from dynamical models.We will firstly look at the expected signature of additional planets at Trappist-1 on the transit times of the known planets to determine at what distances putatuve planets can be ruled out.Secondly, the remarkably compact configuration of Trappist-1 ensures that the known planets are secularly coupled, keeping their mutual inclinations very small and making their cotransiting geometry likely if Trappist-1h transits. We determine the range of masses and orbital inclinations of a putatuve outer planet that would make the observed configuration unlikely, and compare these to these constraints to those expected from radial velocity observations.

  10. Constraints on a possible variation of the fine structure constant from galaxy cluster data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Holanda, R.F.L.; Landau, S.J.; Sánchez G, I.E.

    2016-05-01

    We propose a new method to probe a possible time evolution of the fine structure constant α from X-ray and Sunyaev-Zel'dovich measurements of the gas mass fraction ( f {sub gas}) in galaxy clusters. Taking into account a direct relation between variations of α and violations of the distance-duality relation, we discuss constraints on α for a class of dilaton runaway models. Although not yet competitive with bounds from high- z quasar absorption systems, our constraints, considering a sample of 29 measurements of f {sub gas}, in the redshift interval 0.14 < z < 0.89, provide an independent estimate ofmore » α variation at low and intermediate redshifts. Furthermore, current and planned surveys will provide a larger amount of data and thus allow to improve the limits on α variation obtained in the present analysis.« less

  11. Cosmic equation of state from combined angular diameter distances: Does the tension with luminosity distances exist?

    NASA Astrophysics Data System (ADS)

    Cao, Shuo; Zhu, Zong-Hong

    2014-10-01

    Using relatively complete observational data concerning four angular diameter distance (ADD) measurements and combined SN +GRB observations representing current luminosity distance (LD) data, this paper investigates the compatibility of these two cosmological distances considering three classes of dark energy equation of state (EoS) reconstruction. In particular, we use strongly gravitationally lensed systems from various large systematic gravitational lens surveys and galaxy clusters, which yield the Hubble constant independent ratio between two angular diameter distances Dl s/Ds data. Our results demonstrate that, with more general categories of standard ruler data, ADD and LD data are compatible at 1 σ level. Second, we note that consistency between ADD and LD data is maintained irrespective of the EoS parametrizations: there is a good match between the universally explored Chevalier-Polarski-Linder model and other formulations of cosmic equation of state. Especially for the truncated generalized equation of state (GEoS) model with β =-2 , the conclusions obtained with ADD and LD are almost the same. Finally, statistical analysis of generalized dark energy equation of state performed on four classes of ADD data provides stringent constraints on the EoS parameters w0 , wβ, and β , which suggest that dark energy was a subdominant component at early times. Moreover, the GEoS parametrization with β ≃1 seems to be a more favorable two-parameter model to characterize the cosmic equation of state, because the combined angular diameter distance data (SGL +CBF +BAO +WMAP 9 ) provide the best-fit value β =0.75 1-0.480+0.465 .

  12. Modeling absolute plate and plume motions

    NASA Astrophysics Data System (ADS)

    Bodinier, G. P.; Wessel, P.; Conrad, C. P.

    2016-12-01

    Paleomagnetic evidence for plume drift has made modeling of absolute plate motions challenging, especially since direct observations of plume drift are lacking. Predictions of plume drift arising from mantle convection models and broadly satisfying observed paleolatitudes have so far provided the only framework for deriving absolute plate motions over moving hotspots. However, uncertainties in mantle rheology, temperature, and initial conditions make such models nonunique. Using simulated and real data, we will show that age progressions along Pacific hotspot trails provide strong constraints on plume motions for all major trails, and furthermore that it is possible to derive models for relative plume drift from these data alone. Relative plume drift depends on the inter-hotspot distances derived from age progressions but lacks a fixed reference point and orientation. By incorporating paleolatitude histories for the Hawaii and Louisville chains we add further constraints on allowable plume motions, yet one unknown parameter remains: a longitude shift that applies equally to all plumes. To obtain a solution we could restrict either the Hawaii or Louisville plume to have latitudinal motion only, thus satisfying paleolatitude constraints. Yet, restricting one plume to latitudinal motion while all others move freely is not realistic. Consequently, it is only possible to resolve the motion of hotspots relative to an overall and unknown longitudinal shift as a function of time. Our plate motions are therefore dependent on the same shift via an unknown rotation about the north pole. Yet, as plume drifts are consequences of mantle convection, our results place strong constraints on the pattern of convection. Other considerations, such as imposed limits on plate speed, plume speed, proximity to LLSVP edges, model smoothness, or relative plate motions via ridge-spotting may add further constraints that allow a unique model of Pacific absolute plate and plume motions to be inferred. Our modeling suggests that the acquisition of new age and paleomagnetic data from hotspot trails where data are lacking would add valuable constraints on both plume and plate motions. At present, the limiting factor is inconsistencies between paleomagnetic, geometric, and chronologic data, leading to large uncertainties in the results.

  13. Increasing health worker capacity through distance learning: a comprehensive review of programmes in Tanzania.

    PubMed

    Nartker, Anya J; Stevens, Liz; Shumays, Alyson; Kalowela, Martin; Kisimbo, Daniel; Potter, Katy

    2010-12-31

    Tanzania, like many developing countries, faces a crisis in human resources for health. The government has looked for ways to increase the number and skills of health workers, including using distance learning in their training. In 2008, the authors reviewed and assessed the country's current distance learning programmes for health care workers, as well as those in countries with similar human resource challenges, to determine the feasibility of distance learning to meet the need of an increased and more skilled health workforce. Data were collected from 25 distance learning programmes at health training institutions, universities, and non-governmental organizations throughout the country from May to August 2008. Methods included internet research; desk review; telephone, email and mail-in surveys; on-site observations; interviews with programme managers, instructors, students, information technology specialists, preceptors, health care workers and Ministry of Health and Social Welfare representatives; and a focus group with national HIV/AIDS care and treatment organizations. Challenges include lack of guidelines for administrators, instructors and preceptors of distance learning programmes regarding roles and responsibilities; absence of competencies for clinical components of curricula; and technological constraints such as lack of access to computers and to the internet. Insufficient funding resulted in personnel shortages, lack of appropriate training for personnel, and lack of materials for students.Nonetheless, current and prospective students expressed overwhelming enthusiasm for scale-up of distance learning because of the unique financial and social benefits offered by these programs. Participants were retained as employees in their health care facilities, and remained in their communities and supported their families while advancing their careers. Space in health training institutions was freed up for new students entering in-residence pre-service training. A blended print-based distance learning model is most feasible at the national level due to current resource and infrastructure constraints. With an increase in staffing; improvement of infrastructure, coordination and curricula; and decentralization to the zonal or district level, distance learning can be an effective method to increase both the skills and the numbers of qualified health care workers capable of meeting the health care needs of the Tanzanian population.

  14. Increasing health worker capacity through distance learning: a comprehensive review of programmes in Tanzania

    PubMed Central

    2010-01-01

    Background Tanzania, like many developing countries, faces a crisis in human resources for health. The government has looked for ways to increase the number and skills of health workers, including using distance learning in their training. In 2008, the authors reviewed and assessed the country's current distance learning programmes for health care workers, as well as those in countries with similar human resource challenges, to determine the feasibility of distance learning to meet the need of an increased and more skilled health workforce. Methods Data were collected from 25 distance learning programmes at health training institutions, universities, and non-governmental organizations throughout the country from May to August 2008. Methods included internet research; desk review; telephone, email and mail-in surveys; on-site observations; interviews with programme managers, instructors, students, information technology specialists, preceptors, health care workers and Ministry of Health and Social Welfare representatives; and a focus group with national HIV/AIDS care and treatment organizations. Results Challenges include lack of guidelines for administrators, instructors and preceptors of distance learning programmes regarding roles and responsibilities; absence of competencies for clinical components of curricula; and technological constraints such as lack of access to computers and to the internet. Insufficient funding resulted in personnel shortages, lack of appropriate training for personnel, and lack of materials for students. Nonetheless, current and prospective students expressed overwhelming enthusiasm for scale-up of distance learning because of the unique financial and social benefits offered by these programs. Participants were retained as employees in their health care facilities, and remained in their communities and supported their families while advancing their careers. Space in health training institutions was freed up for new students entering in-residence pre-service training. Conclusions A blended print-based distance learning model is most feasible at the national level due to current resource and infrastructure constraints. With an increase in staffing; improvement of infrastructure, coordination and curricula; and decentralization to the zonal or district level, distance learning can be an effective method to increase both the skills and the numbers of qualified health care workers capable of meeting the health care needs of the Tanzanian population. PMID:21194417

  15. A Critical Interpersonal Distance Switches between Two Coordination Modes in Kendo Matches

    PubMed Central

    Okumura, Motoki; Kijima, Akifumi; Kadota, Koji; Yokoyama, Keiko; Suzuki, Hiroo; Yamamoto, Yuji

    2012-01-01

    In many competitive sports, players need to quickly and continuously execute movements that co-adapt to various movements executed by their opponents and physical objects. In a martial art such as kendo, players must be able to skillfully change interpersonal distance in order to win. However, very little information about the task and expertise properties of the maneuvers affecting interpersonal distance is available. This study investigated behavioral dynamics underlying opponent tasks by analyzing changes in interpersonal distance made by expert players in kendo matches. Analysis of preferred interpersonal distances indicated that players tended to step toward and away from their opponents based on two distances. The most preferred distance enabled the players to execute both striking and defensive movements immediately. The relative phase analysis of the velocities at which players executed steps toward and away revealed that players developed anti-phase synchronizations at near distances to maintain safe distances from their opponents. Alternatively, players shifted to in-phase synchronization to approach their opponents from far distances. This abrupt phase-transition phenomenon constitutes a characteristic bifurcation dynamics that regularly and instantaneously occurs between in- and anti-phase synchronizations at a critical interpersonal distance. These dynamics are profoundly affected by the task constraints of kendo and the physical constraints of the players. Thus, the current study identifies the clear behavioral dynamics that emerge in a sport setting. PMID:23284799

  16. Syn-eruptive CO2 Degassing of Submarine Lavas Flows: Constraints on Eruption Dynamics

    NASA Astrophysics Data System (ADS)

    Soule, S. A.; Boulahanis, B.; Fundis, A.; Clague, D. A.; Chadwick, B.

    2013-12-01

    At fast- and intermediate-spreading rate mid-ocean ridges, quenched lava samples are commonly supersaturated in CO2 with concentrations similar to the pressure/depth of shallow crustal melt lenses. This supersaturation is attributed to rapid ascent and decompression rates that exceed the kinetic rates of bubble nucleation and growth. During emplacement, CO2 supersaturated lavas experience nearly isothermal and isobaric conditions over a period of hours. A recent study has demonstrated systematic decreases in CO2 with increasing transport distance (i.e. time) along a single flow pathway within the 2005-06 eruption at the East Pacific Rise (~2500 m.b.s.l.). Based on analysis of vesicle population characteristics and complementary noble gas measurements, it is proposed that diffusion of CO2 into bubbles can be used as a basis to model the gas loss from the melt and thus place constraints on the dynamics of the eruption. We suggest that submarine lava flows represent a natural experiment in degassing that isolates conditions of low to moderate supersaturation and highlights timescales of diffusion and vesiculation processes that are relevant to shallow crustal and conduit processes in subaerial basaltic volcanic systems. Here we report a new suite of volatile concentration analyses and vesicle size distributions from the 2011 eruption of Axial Volcano along the Juan de Fuca Ridge (~1500 m.b.s.l.). The lava flows from this eruption are mapped by differencing of repeat high-resolution bathymetric surveys, so that the geologic context of the samples is known. In addition, in-situ instrument records record the onset of the eruption and place constraints on timing that can be used to verify estimates of eruption dynamics derived from degassing. This sample suite provides a comprehensive view of the variability in volatile concentrations within a submarine eruption and new constraints for evaluating models of degassing and vesiculation. Initial results show systematic variability in CO2 supersaturation along eruptive fissures as well as with increasing distance along flows pathways providing constraints on threshold decompression rates required to nucleate and grow bubbles in a basaltic melt, timescales of degassing in natural systems, and the properties of consequent vesicle populations.

  17. New Constraints on Dark Energy from Chandra X-rayObservations of the Largest Relaxed Galaxy Clusters

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Allen, S.W.; Rapetti, D.A.; /KIPAC, Menlo Park

    2007-06-06

    We present constraints on the mean matter density, {Omega}{sub m}, dark energy density, {Omega}{sub DE}, and the dark energy equation of state parameter, w, using Chandra measurements of the X-ray gas mass fraction (fgas) in 42 hot (kT > 5keV), X-ray luminous, dynamically relaxed galaxy clusters spanning the redshift range 0.05 < z < 1.1. Using only the fgas data for the 6 lowest redshift clusters at z < 0.15, for which dark energy has a negligible effect on the measurements, we measure {Omega}{sub m}=0.28{+-}0.06 (68% confidence, using standard priors on the Hubble Constant, H{sub 0}, and mean baryon density,more » {Omega}{sub b}h{sup 2}). Analyzing the data for all 42 clusters, employing only weak priors on H{sub 0} and {Omega}{sub b}h{sup 2}, we obtain a similar result on {Omega}{sub m} and detect the effects of dark energy on the distances to the clusters at {approx}99.99% confidence, with {Omega}{sub DE}=0.86{+-}0.21 for a non-flat LCDM model. The detection of dark energy is comparable in significance to recent SNIa studies and represents strong, independent evidence for cosmic acceleration. Systematic scatter remains undetected in the f{sub gas} data, despite a weighted mean statistical scatter in the distance measurements of only {approx}5%. For a flat cosmology with constant w, we measure {Omega}{sub m}=0.28{+-}0.06 and w=-1.14{+-}0.31. Combining the fgas data with independent constraints from CMB and SNIa studies removes the need for priors on {Omega}{sub b}h{sup 2} and H{sub 0} and leads to tighter constraints: {Omega}{sub m}=0.253{+-}0.021 and w=-0.98{+-}0.07 for the same constant-w model. More general analyses in which we relax the assumption of flatness and/or allow evolution in w remain consistent with the cosmological constant paradigm. Our analysis includes conservative allowances for systematic uncertainties. The small systematic scatter and tight constraints bode well for future dark energy studies using the f{sub gas} method.« less

  18. Correlation Between the Effective Neutrino Number and Curvature

    NASA Astrophysics Data System (ADS)

    Smith, Aaron; Archidiacono, M.; Cooray, A.; De Bernardis, F.; Melchiorri, A.; Smidt, J.

    2012-01-01

    Cosmological data seems to favor models with more than three neutrinos. This poster focuses on recent discussion regarding additional sterile neutrinos and neutrino mass constraints in cosmology. We present a theoretical argument for correlation between the number of effective neutrinos and the curvature of the universe. This naturally arises from simple considerations of distance measurements. For example, with the degree of damping prior to recombination fixed by observation, we find that if we allow for an open universe then the angular diameter distance increases. To counterbalance this effect the sound horizon distance must increase as well which corresponds to decreasing the effective neutrino number. This qualitative argument is confirmed by statistical analysis with CosmoMC adapted to include CMB anisotropy measurements from a variety of experiments. This research was supported by Asantha Cooray at the University of California, Irvine.

  19. The metabolic cost of changing walking speeds is significant, implies lower optimal speeds for shorter distances, and increases daily energy estimates.

    PubMed

    Seethapathi, Nidhi; Srinivasan, Manoj

    2015-09-01

    Humans do not generally walk at constant speed, except perhaps on a treadmill. Normal walking involves starting, stopping and changing speeds, in addition to roughly steady locomotion. Here, we measure the metabolic energy cost of walking when changing speed. Subjects (healthy adults) walked with oscillating speeds on a constant-speed treadmill, alternating between walking slower and faster than the treadmill belt, moving back and forth in the laboratory frame. The metabolic rate for oscillating-speed walking was significantly higher than that for constant-speed walking (6-20% cost increase for ±0.13-0.27 m s(-1) speed fluctuations). The metabolic rate increase was correlated with two models: a model based on kinetic energy fluctuations and an inverted pendulum walking model, optimized for oscillating-speed constraints. The cost of changing speeds may have behavioural implications: we predicted that the energy-optimal walking speed is lower for shorter distances. We measured preferred human walking speeds for different walking distances and found people preferred lower walking speeds for shorter distances as predicted. Further, analysing published daily walking-bout distributions, we estimate that the cost of changing speeds is 4-8% of daily walking energy budget. © 2015 The Author(s).

  20. The metabolic cost of changing walking speeds is significant, implies lower optimal speeds for shorter distances, and increases daily energy estimates

    PubMed Central

    Seethapathi, Nidhi; Srinivasan, Manoj

    2015-01-01

    Humans do not generally walk at constant speed, except perhaps on a treadmill. Normal walking involves starting, stopping and changing speeds, in addition to roughly steady locomotion. Here, we measure the metabolic energy cost of walking when changing speed. Subjects (healthy adults) walked with oscillating speeds on a constant-speed treadmill, alternating between walking slower and faster than the treadmill belt, moving back and forth in the laboratory frame. The metabolic rate for oscillating-speed walking was significantly higher than that for constant-speed walking (6–20% cost increase for ±0.13–0.27 m s−1 speed fluctuations). The metabolic rate increase was correlated with two models: a model based on kinetic energy fluctuations and an inverted pendulum walking model, optimized for oscillating-speed constraints. The cost of changing speeds may have behavioural implications: we predicted that the energy-optimal walking speed is lower for shorter distances. We measured preferred human walking speeds for different walking distances and found people preferred lower walking speeds for shorter distances as predicted. Further, analysing published daily walking-bout distributions, we estimate that the cost of changing speeds is 4–8% of daily walking energy budget. PMID:26382072

  1. Heavy quarkonium hybrids: Spectrum, decay, and mixing

    NASA Astrophysics Data System (ADS)

    Oncala, Ruben; Soto, Joan

    2017-07-01

    We present a largely model-independent analysis of the lighter heavy quarkonium hybrids based on the strong coupling regime of potential nonrelativistic QCD. We calculate the spectrum at leading order, including the mixing of static hybrid states. We use potentials that fulfill the required short and long distance theoretical constraints and fit well the available lattice data. We argue that the decay width to the lower lying heavy quarkonia can be reliably estimated in some cases and provide results for a selected set of decays. We also consider the mixing with heavy quarkonium states. We establish the form of the mixing potential at O (1 /mQ) , mQ being the mass of the heavy quarks, and work out its short and long distance constraints. The weak coupling regime of potential nonrelativistic QCD and the effective string theory of QCD are used for that goal. We show that the mixing effects may indeed be important and produce large spin symmetry violations. Most of the isospin zero XYZ states fit well in our spectrum, either as a hybrid or standard quarkonium candidate.

  2. Implementation of Elaboration Theory in Material Design for Distance Education

    ERIC Educational Resources Information Center

    Cakiroglu, Unal; Ozturk, Mucahit

    2014-01-01

    Distance Education is a kind of teaching in which a variety of teaching activities and the communication between students are achieved through peculiarly prepared contents and environments at a certain station in the cases when there is no possibility to conduct in-class activities. One of the most significant constraints of distance education…

  3. First X-ray Statistical Tests for Clumpy-Torus Models: Constraints from RXTEmonitoring of Seyfert AGN

    NASA Astrophysics Data System (ADS)

    Markowitz, Alex; Krumpe, Mirko; Nikutta, R.

    2016-06-01

    In two papers (Markowitz, Krumpe, & Nikutta 2014, and Nikutta et al., in prep.), we derive the first X-ray statistical constraints for clumpy-torus models in Seyfert AGN by quantifying multi-timescale variability in line of-sight X-ray absorbing gas as a function of optical classification.We systematically search for discrete absorption events in the vast archive of RXTE monitoring of 55 nearby type Is and Compton-thin type IIs. We are sensitive to discrete absorption events due to clouds of full-covering, neutral/mildly ionized gas transiting the line of sight. Our results apply to both dusty and non-dusty clumpy media, and probe model parameter space complementary to that for eclipses observed with XMM-Newton, Suzaku, and Chandra.We detect twelve eclipse events in eight Seyferts, roughly tripling the number previously published from this archive. Event durations span hours to years. Most of our detected clouds are Compton-thin, and most clouds' distances from the black hole are inferred to be commensurate with the outer portions of the BLR or the inner regions of infrared-emitting dusty tori.We present the density profiles of the highest-quality eclipse events; the column density profile for an eclipsing cloud in NGC 3783 is doubly spiked, possibly indicating a cloud that is being tidallysheared. We discuss implications for cloud distributions in the context of clumpy-torus models. We calculate eclipse probabilities for orientation-dependent Type I/II unification schemes.We present constraints on cloud sizes, stability, and radial distribution. We infer that clouds' small angular sizes as seen from the SMBH imply 107 clouds required across the BLR + torus. Cloud size is roughly proportional to distance from the black hole, hinting at the formation processes (e.g., disk fragmentation). All observed clouds are sub-critical with respect to tidal disruption; self-gravity alone cannot contain them. External forces, such as magnetic fields or ambient pressure, are needed to contain them; otherwise, clouds must be short-lived.

  4. Restricted DCJ-indel model: sorting linear genomes with DCJ and indels

    PubMed Central

    2012-01-01

    Background The double-cut-and-join (DCJ) is a model that is able to efficiently sort a genome into another, generalizing the typical mutations (inversions, fusions, fissions, translocations) to which genomes are subject, but allowing the existence of circular chromosomes at the intermediate steps. In the general model many circular chromosomes can coexist in some intermediate step. However, when the compared genomes are linear, it is more plausible to use the so-called restricted DCJ model, in which we proceed the reincorporation of a circular chromosome immediately after its creation. These two consecutive DCJ operations, which create and reincorporate a circular chromosome, mimic a transposition or a block-interchange. When the compared genomes have the same content, it is known that the genomic distance for the restricted DCJ model is the same as the distance for the general model. If the genomes have unequal contents, in addition to DCJ it is necessary to consider indels, which are insertions and deletions of DNA segments. Linear time algorithms were proposed to compute the distance and to find a sorting scenario in a general, unrestricted DCJ-indel model that considers DCJ and indels. Results In the present work we consider the restricted DCJ-indel model for sorting linear genomes with unequal contents. We allow DCJ operations and indels with the following constraint: if a circular chromosome is created by a DCJ, it has to be reincorporated in the next step (no other DCJ or indel can be applied between the creation and the reincorporation of a circular chromosome). We then develop a sorting algorithm and give a tight upper bound for the restricted DCJ-indel distance. Conclusions We have given a tight upper bound for the restricted DCJ-indel distance. The question whether this bound can be reduced so that both the general and the restricted DCJ-indel distances are equal remains open. PMID:23281630

  5. Wide-Spectrum Microscope with a Long Working Distance Aspherical Objective Based on Obscuration Constraint

    PubMed Central

    Wang, Weibo; Wang, Chao; Liu, Jian; Tan, Jiubin

    2016-01-01

    We present an approach for an initial configuration design based on obscuration constraint and on-axis Taylor series expansion to realize the design of long working distance microscope (numerical aperture (NA) = 0.13 and working distance (WD) = 525 mm) with a low obscuration aspherical Schwarzschild objective in wide-spectrum imaging (λ = 400–900 nm). Experiments of the testing on the resolution target and inspection on United States Air Force (USAF) resolution chart and a line charge-coupled device (CCD) (pixel size of 14 μm × 56 μm) with different wavelength light sources (λ = 480 nm, 550 nm, 660 nm, 850 nm) were implemented to verify the validity of the proposed method. PMID:27834874

  6. Invalid-point removal based on epipolar constraint in the structured-light method

    NASA Astrophysics Data System (ADS)

    Qi, Zhaoshuai; Wang, Zhao; Huang, Junhui; Xing, Chao; Gao, Jianmin

    2018-06-01

    In structured-light measurement, there unavoidably exist many invalid points caused by shadows, image noise and ambient light. According to the property of the epipolar constraint, because the retrieved phase of the invalid point is inaccurate, the corresponding projector image coordinate (PIC) will not satisfy the epipolar constraint. Based on this fact, a new invalid-point removal method based on the epipolar constraint is proposed in this paper. First, the fundamental matrix of the measurement system is calculated, which will be used for calculating the epipolar line. Then, according to the retrieved phase map of the captured fringes, the PICs of each pixel are retrieved. Subsequently, the epipolar line in the projector image plane of each pixel is obtained using the fundamental matrix. The distance between the corresponding PIC and the epipolar line of a pixel is defined as the invalidation criterion, which quantifies the satisfaction degree of the epipolar constraint. Finally, all pixels with a distance larger than a certain threshold are removed as invalid points. Experiments verified that the method is easy to implement and demonstrates better performance than state-of-the-art measurement systems.

  7. Auditory normalization of French vowels synthesized by an articulatory model simulating growth from birth to adulthood

    NASA Astrophysics Data System (ADS)

    Ménard, Lucie; Schwartz, Jean-Luc; Boë, Louis-Jean; Kandel, Sonia; Vallée, Nathalie

    2002-04-01

    The present article aims at exploring the invariant parameters involved in the perceptual normalization of French vowels. A set of 490 stimuli, including the ten French vowels eye, why, you, ee, ø oh, eh, oelig, openo, aye produced by an articulatory model, simulating seven growth stages and seven fundamental frequency values, has been submitted as a perceptual identification test to 43 subjects. The results confirm the important effect of the tonality distance between F1 and f0 in perceived height. It does not seem, however, that height perception involves a binary organization determined by the 3-3.5-Bark critical distance. Regarding place of articulation, the tonotopic distance between F1 and F2 appears to be the best predictor of the perceived front-back dimension. Nevertheless, the role of the difference between F2 and F3 remains important. Roundedness is also examined and correlated to the effective second formant, involving spectral integration of higher formants within the 3.5-Bark critical distance. The results shed light on the issue of perceptual invariance, and can be interpreted as perceptual constraints imposed on speech production.

  8. Canali-type channels on Venus - Some genetic constraints

    NASA Technical Reports Server (NTRS)

    Komatsu, Goro; Kargel, Jeffrey S.; Baker, Victor R.

    1992-01-01

    Canali-type channels on Venus are unique because of their great lengths (up to 6800 km) and nearly constant channel cross sectional shapes along their paths. A simple model incorporating channel flow and radiative cooling suggests that common terrestrial-type tholeiite lava cannot sustain a superheated and turbulent state for the long distances required for thermal erosion of canali within allowable discharge rates. If canali formed mainly by constructional processes, laminar tholeiitic flow of relatively high, sustained discharge rates might travel the observed distances, but the absence of levees would need to be explained. An exotic low temperature, low viscosity lava like carbonatite or sulfur seems to be required for the erosional genesis of canali.

  9. Distance-Based and Low Energy Adaptive Clustering Protocol for Wireless Sensor Networks

    PubMed Central

    Gani, Abdullah; Anisi, Mohammad Hossein; Ab Hamid, Siti Hafizah; Akhunzada, Adnan; Khan, Muhammad Khurram

    2016-01-01

    A wireless sensor network (WSN) comprises small sensor nodes with limited energy capabilities. The power constraints of WSNs necessitate efficient energy utilization to extend the overall network lifetime of these networks. We propose a distance-based and low-energy adaptive clustering (DISCPLN) protocol to streamline the green issue of efficient energy utilization in WSNs. We also enhance our proposed protocol into the multi-hop-DISCPLN protocol to increase the lifetime of the network in terms of high throughput with minimum delay time and packet loss. We also propose the mobile-DISCPLN protocol to maintain the stability of the network. The modelling and comparison of these protocols with their corresponding benchmarks exhibit promising results. PMID:27658194

  10. Contact Prediction for Beta and Alpha-Beta Proteins Using Integer Linear Optimization and its Impact on the First Principles 3D Structure Prediction Method ASTRO-FOLD

    PubMed Central

    Rajgaria, R.; Wei, Y.; Floudas, C. A.

    2010-01-01

    An integer linear optimization model is presented to predict residue contacts in β, α + β, and α/β proteins. The total energy of a protein is expressed as sum of a Cα – Cα distance dependent contact energy contribution and a hydrophobic contribution. The model selects contacts that assign lowest energy to the protein structure while satisfying a set of constraints that are included to enforce certain physically observed topological information. A new method based on hydrophobicity is proposed to find the β-sheet alignments. These β-sheet alignments are used as constraints for contacts between residues of β-sheets. This model was tested on three independent protein test sets and CASP8 test proteins consisting of β, α + β, α/β proteins and was found to perform very well. The average accuracy of the predictions (separated by at least six residues) was approximately 61%. The average true positive and false positive distances were also calculated for each of the test sets and they are 7.58 Å and 15.88 Å, respectively. Residue contact prediction can be directly used to facilitate the protein tertiary structure prediction. This proposed residue contact prediction model is incorporated into the first principles protein tertiary structure prediction approach, ASTRO-FOLD. The effectiveness of the contact prediction model was further demonstrated by the improvement in the quality of the protein structure ensemble generated using the predicted residue contacts for a test set of 10 proteins. PMID:20225257

  11. On Global Optimal Sailplane Flight Strategy

    NASA Technical Reports Server (NTRS)

    Sander, G. J.; Litt, F. X.

    1979-01-01

    The derivation and interpretation of the necessary conditions that a sailplane cross-country flight has to satisfy to achieve the maximum global flight speed is considered. Simple rules are obtained for two specific meteorological models. The first one uses concentrated lifts of various strengths and unequal distance. The second one takes into account finite, nonuniform space amplitudes for the lifts and allows, therefore, for dolphin style flight. In both models, altitude constraints consisting of upper and lower limits are shown to be essential to model realistic problems. Numerical examples illustrate the difference with existing techniques based on local optimality conditions.

  12. Hierarchical clustering using correlation metric and spatial continuity constraint

    DOEpatents

    Stork, Christopher L.; Brewer, Luke N.

    2012-10-02

    Large data sets are analyzed by hierarchical clustering using correlation as a similarity measure. This provides results that are superior to those obtained using a Euclidean distance similarity measure. A spatial continuity constraint may be applied in hierarchical clustering analysis of images.

  13. Personality Homophily and Geographic Distance in Facebook.

    PubMed

    Noë, Nyala; Whitaker, Roger M; Allen, Stuart M

    2018-05-24

    Personality homophily remains an understudied aspect of social networks, with the traditional focus concerning sociodemographic variables as the basis for assortativity, rather than psychological dispositions. We consider the effect of personality homophily on one of the biggest constraints to human social networks: geographic distance. We use the Big five model of personality to make predictions for each of the five facets: Openness to experience, Conscientiousness, Extraversion, Agreeableness, and Neuroticism. Using a network of 313,669 Facebook users, we investigate the difference in geographic distance between homophilous pairs, in which both users scored similarly on a particular facet, and mixed pairs. In accordance with our hypotheses, we find that pairs of open and conscientious users are geographically further apart than mixed pairs. Pairs of extraverts, on the other hand, tend to be geographically closer together. We find mixed results for the Neuroticism facet, and no significant effects for the Agreeableness facet. The results are discussed in the context of personality homophily and the impact of geographic distance on social connections.

  14. An Experimentally Robust Model of Monomeric Apolipoprotein A-I Created from a Chimera of Two X-ray Structures and Molecular Dynamics Simulations

    PubMed Central

    2015-01-01

    High-density lipoprotein (HDL) retards atherosclerosis by accepting cholesterol from the artery wall. However, the structure of the proposed acceptor, monomeric apolipoprotein A-I (apoA-I), the major protein of HDL, is poorly understood. Two published models for monomeric apoA-I used cross-linking distance constraints to derive best fit conformations. This approach has limitations. (i) Cross-linked peptides provide no information about secondary structure. (ii) A protein chain can be folded in multiple ways to create a best fit. (iii) Ad hoc folding of a secondary structure is unlikely to produce a stable orientation of hydrophobic and hydrophilic residues. To address these limitations, we used a different approach. We first noted that the dimeric apoA-I crystal structure, (Δ185–243)apoA-I, is topologically identical to a monomer in which helix 5 forms a helical hairpin, a monomer with a hydrophobic cleft running the length of the molecule. We then realized that a second crystal structure, (Δ1–43)apoA-I, contains a C-terminal structure that fits snuggly via aromatic and hydrophobic interactions into the hydrophobic cleft. Consequently, we combined these crystal structures into an initial model that was subjected to molecular dynamics simulations. We tested the initial and simulated models and the two previously published models in three ways: against two published data sets (domains predicted to be helical by H/D exchange and six spin-coupled residues) and against our own experimentally determined cross-linking distance constraints. We note that the best fit simulation model, superior by all tests to previously published models, has dynamic features of a molten globule with interesting implications for the functions of apoA-I. PMID:25423138

  15. Learning a Mahalanobis Distance-Based Dynamic Time Warping Measure for Multivariate Time Series Classification.

    PubMed

    Mei, Jiangyuan; Liu, Meizhu; Wang, Yuan-Fang; Gao, Huijun

    2016-06-01

    Multivariate time series (MTS) datasets broadly exist in numerous fields, including health care, multimedia, finance, and biometrics. How to classify MTS accurately has become a hot research topic since it is an important element in many computer vision and pattern recognition applications. In this paper, we propose a Mahalanobis distance-based dynamic time warping (DTW) measure for MTS classification. The Mahalanobis distance builds an accurate relationship between each variable and its corresponding category. It is utilized to calculate the local distance between vectors in MTS. Then we use DTW to align those MTS which are out of synchronization or with different lengths. After that, how to learn an accurate Mahalanobis distance function becomes another key problem. This paper establishes a LogDet divergence-based metric learning with triplet constraint model which can learn Mahalanobis matrix with high precision and robustness. Furthermore, the proposed method is applied on nine MTS datasets selected from the University of California, Irvine machine learning repository and Robert T. Olszewski's homepage, and the results demonstrate the improved performance of the proposed approach.

  16. Integrating Compact Constraint and Distance Regularization with Level Set for Hepatocellular Carcinoma (HCC) Segmentation on Computed Tomography (CT) Images

    NASA Astrophysics Data System (ADS)

    Gui, Luying; He, Jian; Qiu, Yudong; Yang, Xiaoping

    2017-01-01

    This paper presents a variational level set approach to segment lesions with compact shapes on medical images. In this study, we investigate to address the problem of segmentation for hepatocellular carcinoma which are usually of various shapes, variable intensities, and weak boundaries. An efficient constraint which is called the isoperimetric constraint to describe the compactness of shapes is applied in this method. In addition, in order to ensure the precise segmentation and stable movement of the level set, a distance regularization is also implemented in the proposed variational framework. Our method is applied to segment various hepatocellular carcinoma regions on Computed Tomography images with promising results. Comparison results also prove that the proposed method is more accurate than other two approaches.

  17. How dynamic number of evacuee affects the multi-objective optimum allocation for earthquake emergency shelters: A case study in the central area of Beijing, China

    NASA Astrophysics Data System (ADS)

    Ma, Y.; Xu, W.; Zhao, X.; Qin, L.

    2016-12-01

    Accurate location and allocation of earthquake emergency shelters is a key component of effective urban planning and emergency management. A number of models have been developed to solve the complex location-allocation problem with diverse and strict constraints, but there still remain a big gap between the model and the actual situation because the uncertainty of earthquake, damage rate of buildings and evacuee behaviors have been neglected or excessively simplified in the existing models. An innovative model was first developed to estimate the hourly dynamic changes of the number of evacuees under two damage scenarios of earthquake by considering these factors at the community level based on a location-based service data, and then followed by a multi-objective model for the allocation of residents to earthquake shelters using the central area of Beijing, China as a case study. The two objectives of this shelter allocation model were to minimize the total evacuation distance from communities to a specified shelter and to minimize the total area of all the shelters with the constraints of shelter capacity and service radius. The modified particle swarm optimization algorithm was used to solve this model. The results show that increasing the shelter area will result in a large decrease of the total evacuation distance in all of the schemes of the four scenarios (i.e., Scenario A and B in daytime and nighttime respectively). According to the schemes of minimum distance, parts of communities in downtown area needed to be reallocated due to the insufficient capacity of the nearest shelters, and the numbers of these communities sequentially decreased in scenarios Ad, An, Bd and Bn due to the decreasing population. According to the schemes of minimum area in each scenario, 27 or 28 shelters, covering a total area of approximately 37 km2, were selected; and the communities almost evacuated using the same routes in different scenarios. The results can be used as a scientific reference for the planning of shelters in Beijing.

  18. The black hole at the Galactic Center: observations and models in a nutshell

    NASA Astrophysics Data System (ADS)

    Zakharov, Alexander

    2017-12-01

    The Galactic Center (Sgr A*) is a peculiar place in our Galaxy (Milky Way). Our Solar system is located at a distance around 8 kpc from the Galactic Center (GC). There were a number of different including exotic ones such as boson stars, fermion balls, neutrino balls, a cluster of neutron stars. Some of these models are significantly constrained with consequent observations and now supermassive black hole with mass around 4 × 106 M ⊙ is the preferable model for GC. Moreover, one can test alternative theories of gravity with observations of bright stars near the Galactic Center and and observations of bright structures near the black hole at the Galactic Center to reconstruct shadow structure around the black hole with current and future observational VLBI facilities such as the Event Horizon Telescope. In particular, we got a graviton mass constraint which is comparable and consistent with constraints obtained recently by the LIGO-Virgo collaboration.

  19. Obstacle avoidance handling and mixed integer predictive control for space robots

    NASA Astrophysics Data System (ADS)

    Zong, Lijun; Luo, Jianjun; Wang, Mingming; Yuan, Jianping

    2018-04-01

    This paper presents a novel obstacle avoidance constraint and a mixed integer predictive control (MIPC) method for space robots avoiding obstacles and satisfying physical limits during performing tasks. Firstly, a novel kind of obstacle avoidance constraint of space robots, which needs the assumption that the manipulator links and the obstacles can be represented by convex bodies, is proposed by limiting the relative velocity between two closest points which are on the manipulator and the obstacle, respectively. Furthermore, the logical variables are introduced into the obstacle avoidance constraint, which have realized the constraint form is automatically changed to satisfy different obstacle avoidance requirements in different distance intervals between the space robot and the obstacle. Afterwards, the obstacle avoidance constraint and other system physical limits, such as joint angle ranges, the amplitude boundaries of joint velocities and joint torques, are described as inequality constraints of a quadratic programming (QP) problem by using the model predictive control (MPC) method. To guarantee the feasibility of the obtained multi-constraint QP problem, the constraints are treated as soft constraints and assigned levels of priority based on the propositional logic theory, which can realize that the constraints with lower priorities are always firstly violated to recover the feasibility of the QP problem. Since the logical variables have been introduced, the optimization problem including obstacle avoidance and system physical limits as prioritized inequality constraints is termed as MIPC method of space robots, and its computational complexity as well as possible strategies for reducing calculation amount are analyzed. Simulations of the space robot unfolding its manipulator and tracking the end-effector's desired trajectories with the existence of obstacles and physical limits are presented to demonstrate the effectiveness of the proposed obstacle avoidance strategy and MIPC control method of space robots.

  20. Dependency distances in natural mixed languages. Comment on "Dependency distance: A new perspective on syntactic patterns in natural languages" by Haitao Liu et al.

    NASA Astrophysics Data System (ADS)

    Wang, Lin

    2017-07-01

    Haitao Liu et al.'s article [1] offers a comprehensive account of the diversity of syntactic patterns in human languages in terms of an important index of memory burden and syntactic difficulty - the dependency distance. Natural languages, a complex system, present overall shorter dependency distances under the universal pressure for dependency distance minimization; however, there exist some relatively-long-distance dependencies, which reflect that language can constantly adapt itself to some deep-level biological or functional constraints.

  1. Dynamical Constraints on Nontransiting Planets Orbiting TRAPPIST-1

    NASA Astrophysics Data System (ADS)

    Jontof-Hutter, Daniel; Truong, Vinh H.; Ford, Eric B.; Robertson, Paul; Terrien, Ryan C.

    2018-06-01

    We derive lower bounds on the orbital distance and inclination of a putative planet beyond the transiting seven planets of TRAPPIST-1, for a range of masses ranging from 0.08 M Jup to 3.5 M Jup. While the outer architecture of this system will ultimately be constrained by radial velocity measurements over time, we present dynamical constraints from the remarkably coplanar configuration of the seven transiting planets, which is sensitive to modestly inclined perturbers. We find that the observed configuration is unlikely if a Jovian-mass planet inclined by ≥3° to the transiting planet exists within 0.53 au, exceeding any constraints from transit timing variations (TTV) induced in the known planets from an undetected perturber. Our results will inform RV programs targeting TRAPPIST-1, and for near coplanar outer planets, tighter constraints are anticipated for radial velocity (RV) precisions of ≲140 m s‑1. At higher inclinations, putative planets are ruled out to greater orbital distances with orbital periods up to a few years.

  2. Active shape models unleashed

    NASA Astrophysics Data System (ADS)

    Kirschner, Matthias; Wesarg, Stefan

    2011-03-01

    Active Shape Models (ASMs) are a popular family of segmentation algorithms which combine local appearance models for boundary detection with a statistical shape model (SSM). They are especially popular in medical imaging due to their ability for fast and accurate segmentation of anatomical structures even in large and noisy 3D images. A well-known limitation of ASMs is that the shape constraints are over-restrictive, because the segmentations are bounded by the Principal Component Analysis (PCA) subspace learned from the training data. To overcome this limitation, we propose a new energy minimization approach which combines an external image energy with an internal shape model energy. Our shape energy uses the Distance From Feature Space (DFFS) concept to allow deviations from the PCA subspace in a theoretically sound and computationally fast way. In contrast to previous approaches, our model does not rely on post-processing with constrained free-form deformation or additional complex local energy models. In addition to the energy minimization approach, we propose a new method for liver detection, a new method for initializing an SSM and an improved k-Nearest Neighbour (kNN)-classifier for boundary detection. Our ASM is evaluated with leave-one-out tests on a data set with 34 tomographic CT scans of the liver and is compared to an ASM with standard shape constraints. The quantitative results of our experiments show that we achieve higher segmentation accuracy with our energy minimization approach than with standard shape constraints.nym

  3. Protograph LDPC Codes with Node Degrees at Least 3

    NASA Technical Reports Server (NTRS)

    Divsalar, Dariush; Jones, Christopher

    2006-01-01

    In this paper we present protograph codes with a small number of degree-3 nodes and one high degree node. The iterative decoding threshold for proposed rate 1/2 codes are lower, by about 0.2 dB, than the best known irregular LDPC codes with degree at least 3. The main motivation is to gain linear minimum distance to achieve low error floor. Also to construct rate-compatible protograph-based LDPC codes for fixed block length that simultaneously achieves low iterative decoding threshold and linear minimum distance. We start with a rate 1/2 protograph LDPC code with degree-3 nodes and one high degree node. Higher rate codes are obtained by connecting check nodes with degree-2 non-transmitted nodes. This is equivalent to constraint combining in the protograph. The condition where all constraints are combined corresponds to the highest rate code. This constraint must be connected to nodes of degree at least three for the graph to have linear minimum distance. Thus having node degree at least 3 for rate 1/2 guarantees linear minimum distance property to be preserved for higher rates. Through examples we show that the iterative decoding threshold as low as 0.544 dB can be achieved for small protographs with node degrees at least three. A family of low- to high-rate codes with minimum distance linearly increasing in block size and with capacity-approaching performance thresholds is presented. FPGA simulation results for a few example codes show that the proposed codes perform as predicted.

  4. Figures of merit for present and future dark energy probes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mortonson, Michael J.; Huterer, Dragan; Hu, Wayne

    2010-09-15

    We compare current and forecasted constraints on dynamical dark energy models from Type Ia supernovae and the cosmic microwave background using figures of merit based on the volume of the allowed dark energy parameter space. For a two-parameter dark energy equation of state that varies linearly with the scale factor, and assuming a flat universe, the area of the error ellipse can be reduced by a factor of {approx}10 relative to current constraints by future space-based supernova data and CMB measurements from the Planck satellite. If the dark energy equation of state is described by a more general basis ofmore » principal components, the expected improvement in volume-based figures of merit is much greater. While the forecasted precision for any single parameter is only a factor of 2-5 smaller than current uncertainties, the constraints on dark energy models bounded by -1{<=}w{<=}1 improve for approximately 6 independent dark energy parameters resulting in a reduction of the total allowed volume of principal component parameter space by a factor of {approx}100. Typical quintessence models can be adequately described by just 2-3 of these parameters even given the precision of future data, leading to a more modest but still significant improvement. In addition to advances in supernova and CMB data, percent-level measurement of absolute distance and/or the expansion rate is required to ensure that dark energy constraints remain robust to variations in spatial curvature.« less

  5. The structure of poly(carbonsuboxide) on the atomic scale: a solid-state NMR study.

    PubMed

    Schmedt auf der Günne, Jörn; Beck, Johannes; Hoffbauer, Wilfried; Krieger-Beck, Petra

    2005-07-18

    In this contribution we present a study of the structure of amorphous poly(carbonsuboxide) (C3O2)x by 13C solid-state NMR spectroscopy supported by infrared spectroscopy and chemical analysis. Poly(carbonsuboxide) was obtained by polymerization of carbonsuboxide C3O2, which in turn was synthesized from malonic acid bis(trimethylsilylester). Two different 13C labeling schemes were applied to probe inter- and intramonomeric bonds in the polymer by dipolar solid-state NMR methods and also to allow quantitative 13C MAS NMR spectra. Four types of carbon environments can be distinguished in the NMR spectra. Double-quantum and triple-quantum 2D correlation experiments were used to assign the observed peaks using the through-space and through-bond dipolar coupling. In order to obtain distance constraints for the intermonomeric bonds, double-quantum constant-time experiments were performed. In these experiments an additional filter step was applied to suppress contributions from not directly bonded 13C,13C spin pairs. The 13C NMR intensities, chemical shifts, connectivities and distances gave constraints for both the polymerization mechanism and the short-range order of the polymer. The experimental results were complemented by bond lengths predicted by density functional theory methods for several previously suggested models. Based on the presented evidence we can unambiguously exclude models based on gamma-pyronic units and support models based on alpha-pyronic units. The possibility of planar ladder- and bracelet-like alpha-pyronic structures is discussed.

  6. A Minimal Path Searching Approach for Active Shape Model (ASM)-based Segmentation of the Lung.

    PubMed

    Guo, Shengwen; Fei, Baowei

    2009-03-27

    We are developing a minimal path searching method for active shape model (ASM)-based segmentation for detection of lung boundaries on digital radiographs. With the conventional ASM method, the position and shape parameters of the model points are iteratively refined and the target points are updated by the least Mahalanobis distance criterion. We propose an improved searching strategy that extends the searching points in a fan-shape region instead of along the normal direction. A minimal path (MP) deformable model is applied to drive the searching procedure. A statistical shape prior model is incorporated into the segmentation. In order to keep the smoothness of the shape, a smooth constraint is employed to the deformable model. To quantitatively assess the ASM-MP segmentation, we compare the automatic segmentation with manual segmentation for 72 lung digitized radiographs. The distance error between the ASM-MP and manual segmentation is 1.75 ± 0.33 pixels, while the error is 1.99 ± 0.45 pixels for the ASM. Our results demonstrate that our ASM-MP method can accurately segment the lung on digital radiographs.

  7. Cosmography of f(R)-brane cosmology

    NASA Astrophysics Data System (ADS)

    Bouhmadi-López, Mariam; Capozziello, Salvatore; Cardone, Vincenzo F.

    2010-11-01

    Cosmography is a useful tool to constrain cosmological models, in particular, dark energy models. In the case of modified theories of gravity, where the equations of motion are generally quite complicated, cosmography can contribute to select realistic models without imposing arbitrary choices a priori. Indeed, its reliability is based on the assumptions that the universe is homogeneous and isotropic on large scale and luminosity distance can be “tracked” by the derivative series of the scale factor a(t). We apply this approach to induced gravity brane-world models where an f(R) term is present in the brane effective action. The virtue of the model is to self-accelerate the normal and healthy Dvali-Gabadadze-Porrati branch once the f(R) term deviates from the Hilbert-Einstein action. We show that the model, coming from a fundamental theory, is consistent with the ΛCDM scenario at low redshift. We finally estimate the cosmographic parameters fitting the Union2 Type Ia Supernovae data set and the distance priors from baryon acoustic oscillations and then provide constraints on the present day values of f(R) and its second and third derivatives.

  8. A minimal path searching approach for active shape model (ASM)-based segmentation of the lung

    NASA Astrophysics Data System (ADS)

    Guo, Shengwen; Fei, Baowei

    2009-02-01

    We are developing a minimal path searching method for active shape model (ASM)-based segmentation for detection of lung boundaries on digital radiographs. With the conventional ASM method, the position and shape parameters of the model points are iteratively refined and the target points are updated by the least Mahalanobis distance criterion. We propose an improved searching strategy that extends the searching points in a fan-shape region instead of along the normal direction. A minimal path (MP) deformable model is applied to drive the searching procedure. A statistical shape prior model is incorporated into the segmentation. In order to keep the smoothness of the shape, a smooth constraint is employed to the deformable model. To quantitatively assess the ASM-MP segmentation, we compare the automatic segmentation with manual segmentation for 72 lung digitized radiographs. The distance error between the ASM-MP and manual segmentation is 1.75 +/- 0.33 pixels, while the error is 1.99 +/- 0.45 pixels for the ASM. Our results demonstrate that our ASM-MP method can accurately segment the lung on digital radiographs.

  9. A Minimal Path Searching Approach for Active Shape Model (ASM)-based Segmentation of the Lung

    PubMed Central

    Guo, Shengwen; Fei, Baowei

    2013-01-01

    We are developing a minimal path searching method for active shape model (ASM)-based segmentation for detection of lung boundaries on digital radiographs. With the conventional ASM method, the position and shape parameters of the model points are iteratively refined and the target points are updated by the least Mahalanobis distance criterion. We propose an improved searching strategy that extends the searching points in a fan-shape region instead of along the normal direction. A minimal path (MP) deformable model is applied to drive the searching procedure. A statistical shape prior model is incorporated into the segmentation. In order to keep the smoothness of the shape, a smooth constraint is employed to the deformable model. To quantitatively assess the ASM-MP segmentation, we compare the automatic segmentation with manual segmentation for 72 lung digitized radiographs. The distance error between the ASM-MP and manual segmentation is 1.75 ± 0.33 pixels, while the error is 1.99 ± 0.45 pixels for the ASM. Our results demonstrate that our ASM-MP method can accurately segment the lung on digital radiographs. PMID:24386531

  10. Spatial, socio-economic, and ecological implications of incorporating minimum size constraints in marine protected area network design.

    PubMed

    Metcalfe, Kristian; Vaughan, Gregory; Vaz, Sandrine; Smith, Robert J

    2015-12-01

    Marine protected areas (MPAs) are the cornerstone of most marine conservation strategies, but the effectiveness of each one partly depends on its size and distance to other MPAs in a network. Despite this, current recommendations on ideal MPA size and spacing vary widely, and data are lacking on how these constraints might influence the overall spatial characteristics, socio-economic impacts, and connectivity of the resultant MPA networks. To address this problem, we tested the impact of applying different MPA size constraints in English waters. We used the Marxan spatial prioritization software to identify a network of MPAs that met conservation feature targets, whilst minimizing impacts on fisheries; modified the Marxan outputs with the MinPatch software to ensure each MPA met a minimum size; and used existing data on the dispersal distances of a range of species found in English waters to investigate the likely impacts of such spatial constraints on the region's biodiversity. Increasing MPA size had little effect on total network area or the location of priority areas, but as MPA size increased, fishing opportunity cost to stakeholders increased. In addition, as MPA size increased, the number of closely connected sets of MPAs in networks and the average distance between neighboring MPAs decreased, which consequently increased the proportion of the planning region that was isolated from all MPAs. These results suggest networks containing large MPAs would be more viable for the majority of the region's species that have small dispersal distances, but dispersal between MPA sets and spill-over of individuals into unprotected areas would be reduced. These findings highlight the importance of testing the impact of applying different MPA size constraints because there are clear trade-offs that result from the interaction of size, number, and distribution of MPAs in a network. © 2015 Society for Conservation Biology.

  11. Group-theoretic models of the inversion process in bacterial genomes.

    PubMed

    Egri-Nagy, Attila; Gebhardt, Volker; Tanaka, Mark M; Francis, Andrew R

    2014-07-01

    The variation in genome arrangements among bacterial taxa is largely due to the process of inversion. Recent studies indicate that not all inversions are equally probable, suggesting, for instance, that shorter inversions are more frequent than longer, and those that move the terminus of replication are less probable than those that do not. Current methods for establishing the inversion distance between two bacterial genomes are unable to incorporate such information. In this paper we suggest a group-theoretic framework that in principle can take these constraints into account. In particular, we show that by lifting the problem from circular permutations to the affine symmetric group, the inversion distance can be found in polynomial time for a model in which inversions are restricted to acting on two regions. This requires the proof of new results in group theory, and suggests a vein of new combinatorial problems concerning permutation groups on which group theorists will be needed to collaborate with biologists. We apply the new method to inferring distances and phylogenies for published Yersinia pestis data.

  12. The determination of pair-distance distribution by double electron-electron resonance: regularization by the length of distance discretization with Monte Carlo calculations

    NASA Astrophysics Data System (ADS)

    Dzuba, Sergei A.

    2016-08-01

    Pulsed double electron-electron resonance technique (DEER, or PELDOR) is applied to study conformations and aggregation of peptides, proteins, nucleic acids, and other macromolecules. For a pair of spin labels, experimental data allows for the determination of their distance distribution function, P(r). P(r) is derived as a solution of a first-kind Fredholm integral equation, which is an ill-posed problem. Here, we suggest regularization by increasing the distance discretization length to its upper limit where numerical integration still provides agreement with experiment. This upper limit is found to be well above the lower limit for which the solution instability appears because of the ill-posed nature of the problem. For solving the integral equation, Monte Carlo trials of P(r) functions are employed; this method has an obvious advantage of the fulfillment of the non-negativity constraint for P(r). The regularization by the increasing of distance discretization length for the case of overlapping broad and narrow distributions may be employed selectively, with this length being different for different distance ranges. The approach is checked for model distance distributions and for experimental data taken from literature for doubly spin-labeled DNA and peptide antibiotics.

  13. Increase in dance imprecision with decreasing foraging distance in the honey bee Apis mellifera L. is partly explained by physical constraints.

    PubMed

    Beekman, Madeleine; Doyen, Laurent; Oldroyd, Benjamin P

    2005-12-01

    Honey bee foragers communicate the direction and distance of both food sources and new nest sites to nest mates by means of a symbolic dance language. Interestingly, the precision by which dancers transfer directional information is negatively correlated with the distance to the advertised food source. The 'tuned-error' hypothesis suggests that colonies benefit from this imprecision as it spreads recruits out over a patch of constant size irrespective of the distance to the advertised site. An alternative to the tuned-error hypothesis is that dancers are physically incapable of dancing with great precision for nearby sources. Here we revisit the tuned-error hypothesis by studying the change in dance precision with increasing foraging distance over relatively short distances while controlling for environmental influences. We show that bees indeed increase their dance precision with the increase in foraging distance. However, we also show that dance performed by swarm-scouts for a nearby (30 m) nest site, where there could be no benefit to imprecision, are either without or with only limited directional information. This result suggests that imprecision in dance communication is caused primarily by physical constraints in the ability of dancers to turn around quickly enough when the advertised site is nearby.

  14. The Complete Light-curve Sample of Spectroscopically Confirmed SNe Ia from Pan-STARRS1 and Cosmological Constraints from the Combined Pantheon Sample

    NASA Astrophysics Data System (ADS)

    Scolnic, D. M.; Jones, D. O.; Rest, A.; Pan, Y. C.; Chornock, R.; Foley, R. J.; Huber, M. E.; Kessler, R.; Narayan, G.; Riess, A. G.; Rodney, S.; Berger, E.; Brout, D. J.; Challis, P. J.; Drout, M.; Finkbeiner, D.; Lunnan, R.; Kirshner, R. P.; Sanders, N. E.; Schlafly, E.; Smartt, S.; Stubbs, C. W.; Tonry, J.; Wood-Vasey, W. M.; Foley, M.; Hand, J.; Johnson, E.; Burgett, W. S.; Chambers, K. C.; Draper, P. W.; Hodapp, K. W.; Kaiser, N.; Kudritzki, R. P.; Magnier, E. A.; Metcalfe, N.; Bresolin, F.; Gall, E.; Kotak, R.; McCrum, M.; Smith, K. W.

    2018-06-01

    We present optical light curves, redshifts, and classifications for 365 spectroscopically confirmed Type Ia supernovae (SNe Ia) discovered by the Pan-STARRS1 (PS1) Medium Deep Survey. We detail improvements to the PS1 SN photometry, astrometry, and calibration that reduce the systematic uncertainties in the PS1 SN Ia distances. We combine the subset of 279 PS1 SNe Ia (0.03 < z < 0.68) with useful distance estimates of SNe Ia from the Sloan Digital Sky Survey (SDSS), SNLS, and various low-z and Hubble Space Telescope samples to form the largest combined sample of SNe Ia, consisting of a total of 1048 SNe Ia in the range of 0.01 < z < 2.3, which we call the “Pantheon Sample.” When combining Planck 2015 cosmic microwave background (CMB) measurements with the Pantheon SN sample, we find {{{Ω }}}m=0.307+/- 0.012 and w=-1.026+/- 0.041 for the wCDM model. When the SN and CMB constraints are combined with constraints from BAO and local H 0 measurements, the analysis yields the most precise measurement of dark energy to date: {w}0=-1.007+/- 0.089 and {w}a=-0.222+/- 0.407 for the {w}0{w}aCDM model. Tension with a cosmological constant previously seen in an analysis of PS1 and low-z SNe has diminished after an increase of 2× in the statistics of the PS1 sample, improved calibration and photometry, and stricter light-curve quality cuts. We find that the systematic uncertainties in our measurements of dark energy are almost as large as the statistical uncertainties, primarily due to limitations of modeling the low-redshift sample. This must be addressed for future progress in using SNe Ia to measure dark energy.

  15. A switching formation strategy for obstacle avoidance of a multi-robot system based on robot priority model.

    PubMed

    Dai, Yanyan; Kim, YoonGu; Wee, SungGil; Lee, DongHa; Lee, SukGyu

    2015-05-01

    This paper describes a switching formation strategy for multi-robots with velocity constraints to avoid and cross obstacles. In the strategy, a leader robot plans a safe path using the geometric obstacle avoidance control method (GOACM). By calculating new desired distances and bearing angles with the leader robot, the follower robots switch into a safe formation. With considering collision avoidance, a novel robot priority model, based on the desired distance and bearing angle between the leader and follower robots, is designed during the obstacle avoidance process. The adaptive tracking control algorithm guarantees that the trajectory and velocity tracking errors converge to zero. To demonstrate the validity of the proposed methods, simulation and experiment results present that multi-robots effectively form and switch formation avoiding obstacles without collisions. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  16. Topological Constraints in Directed Polymer Melts

    NASA Astrophysics Data System (ADS)

    Serna, Pablo; Bunin, Guy; Nahum, Adam

    2015-11-01

    Polymers in a melt may be subject to topological constraints, as in the example of unlinked polymer rings. How to do statistical mechanics in the presence of such constraints remains a fundamental open problem. We study the effect of topological constraints on a melt of directed polymers, using simulations of a simple quasi-2D model. We find that fixing the global topology of the melt to be trivial changes the polymer conformations drastically. Polymers of length L wander in the transverse direction only by a distance of order (ln L )ζ with ζ ≃1.5 . This is strongly suppressed in comparison with the Brownian L1 /2 scaling which holds in the absence of the topological constraint. It is also much smaller than the predictions of standard heuristic approaches—in particular the L1 /4 of a mean-field-like "array of obstacles" model—so our results present a sharp challenge to theory. Dynamics are also strongly affected by the constraints, and a tagged monomer in an infinite system performs logarithmically slow subdiffusion in the transverse direction. To cast light on the suppression of the strands' wandering, we analyze the topological complexity of subregions of the melt: the complexity is also logarithmically small, and is related to the wandering by a power law. We comment on insights the results give for 3D melts, directed and nondirected.

  17. Segmentation of anterior cruciate ligament in knee MR images using graph cuts with patient-specific shape constraints and label refinement.

    PubMed

    Lee, Hansang; Hong, Helen; Kim, Junmo

    2014-12-01

    We propose a graph-cut-based segmentation method for the anterior cruciate ligament (ACL) in knee MRI with a novel shape prior and label refinement. As the initial seeds for graph cuts, candidates for the ACL and the background are extracted from knee MRI roughly by means of adaptive thresholding with Gaussian mixture model fitting. The extracted ACL candidate is segmented iteratively by graph cuts with patient-specific shape constraints. Two shape constraints termed fence and neighbor costs are suggested such that the graph cuts prevent any leakage into adjacent regions with similar intensity. The segmented ACL label is refined by means of superpixel classification. Superpixel classification makes the segmented label propagate into missing inhomogeneous regions inside the ACL. In the experiments, the proposed method segmented the ACL with Dice similarity coefficient of 66.47±7.97%, average surface distance of 2.247±0.869, and root mean squared error of 3.538±1.633, which increased the accuracy by 14.8%, 40.3%, and 37.6% from the Boykov model, respectively. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. In vivo dynamical behavior of yeast chromatin modeled as an entangled polymer network with constraint release

    NASA Astrophysics Data System (ADS)

    Wang, Chenxi; Kilfoil, Maria L.

    2013-03-01

    The high fidelity segregation of chromatin is the central problem in cell mitosis. The role of mechanics underlying this, however, is undetermined. Work in this area has largely focused on cytoskeletal elements of the process. Preliminary work in our lab suggests the mechanical properties of chromatin are fundamental in this process. Nevertheless, the mechanical properties of chromatin in the cellular context are not well-characterized. For better understanding of the role of mechanics in this cellular process, and of the chromatin mechanics in vivo generally, a systematic dynamical description of chromatin in vivo is required. Accordingly, we label specific sites on chromatin with fluorescent proteins of different wave lengths, enabling us to detect multiple spots separately in 3D and track their displacements in time inside living yeast cells. We analyze the pairwise cross-correlated motion between spots as a function of relative distance along the DNA contour. Comparison between the reptation model and our data serves to test our conjecture that chromatin in the cell is basically an entangled polymer network under constraints to thermal motion, and removal of constraints by non-thermal cellular processes is expected to affect its dynamic behavior.

  19. The Effect of Syntactic Constraints on the Processing of Backwards Anaphora

    ERIC Educational Resources Information Center

    Kazanina, Nina; Lau, Ellen F.; Lieberman, Moti; Yoshida, Masaya; Phillips, Colin

    2007-01-01

    This article presents three studies that investigate when syntactic constraints become available during the processing of long-distance backwards pronominal dependencies ("backwards anaphora" or "cataphora"). Earlier work demonstrated that in such structures the parser initiates an active search for an antecedent for a pronoun, leading to gender…

  20. Environmental constraints and call evolution in torrent-dwelling frogs.

    PubMed

    Goutte, Sandra; Dubois, Alain; Howard, Samuel D; Marquez, Rafael; Rowley, Jodi J L; Dehling, J Maximilian; Grandcolas, Philippe; Rongchuan, Xiong; Legendre, Frédéric

    2016-04-01

    Although acoustic signals are important for communication in many taxa, signal propagation is affected by environmental properties. Strong environmental constraints should drive call evolution, favoring signals with greater transmission distance and content integrity in a given calling habitat. Yet, few empirical studies have verified this prediction, possibly due to a shortcoming in habitat characterization, which is often too broad. Here we assess the potential impact of environmental constraints on the evolution of advertisement call in four groups of torrent-dwelling frogs in the family Ranidae. We reconstruct the evolution of calling site preferences, both broadly categorized and at a finer scale, onto a phylogenetic tree for 148 species with five markers (∼3600 bp). We test models of evolution for six call traits for 79 species with regard to the reconstructed history of calling site preferences and estimate their ancestral states. We find that in spite of existing morphological constraints, vocalizations of torrent-dwelling species are most probably constrained by the acoustic specificities of torrent habitats and particularly their high level of ambient noise. We also show that a fine-scale characterization of calling sites allows a better perception of the impact of environmental constraints on call evolution. © 2016 The Author(s). Evolution © 2016 The Society for the Study of Evolution.

  1. UAS stealth: target pursuit at constant distance using a bio-inspired motion camouflage guidance law.

    PubMed

    Strydom, Reuben; Srinivasan, Mandyam V

    2017-09-21

    The aim of this study is to derive a guidance law by which an unmanned aerial system(s) (UAS) can pursue a moving target at a constant distance, while concealing its own motion. We derive a closed-form solution for the trajectory of the UAS by imposing two key constraints: (1) the shadower moves in such a way as to be perceived as a stationary object by the shadowee, and (2) the distance between the shadower and shadowee is kept constant. Additionally, the theory presented in this paper considers constraints on the maximum achievable speed and acceleration of the shadower. Our theory is tested through Matlab simulations, which validate the camouflage strategy for both 2D and 3D conditions. Furthermore, experiments using a realistic vision-based implementation are conducted in a virtual environment, where the results demonstrate that even with noisy state information it is possible to remain well camouflaged using the constant distance motion camouflage technique.

  2. Disk Evolution and the Fate of Water

    NASA Astrophysics Data System (ADS)

    Hartmann, Lee; Ciesla, Fred; Gressel, Oliver; Alexander, Richard

    2017-10-01

    We review the general theoretical concepts and observational constraints on the distribution and evolution of water vapor and ice in protoplanetary disks, with a focus on the Solar System. Water is expected to freeze out at distances greater than 1-3 AU from solar-type central stars; more precise estimates are difficult to obtain due to uncertainties in the complex processes involved in disk evolution, including dust growth, settling, and radial drift, and the level of turbulence and viscous dissipation within disks. Interferometric observations are now providing constraints on the positions of CO snow lines, but extrapolation to the unresolved regions where water ice sublimates will require much better theoretical understanding of mass and angular momentum transport in disks as well as more refined comparison of observations with sophisticated disk models.

  3. The radius of the quiescent neutron star in the globular cluster M13

    NASA Astrophysics Data System (ADS)

    Shaw, A. W.; Heinke, C. O.; Steiner, A. W.; Campana, S.; Cohn, H. N.; Ho, W. C. G.; Lugger, P. M.; Servillat, M.

    2018-06-01

    X-ray spectra of quiescent low-mass X-ray binaries containing neutron stars can be fit with atmosphere models to constrain the mass and the radius. Mass-radius constraints can be used to place limits on the equation of state of dense matter. We perform fits to the X-ray spectrum of a quiescent neutron star in the globular cluster M13, utilizing data from ROSAT, Chandra, and XMM-Newton, and constrain the mass-radius relation. Assuming an atmosphere composed of hydrogen and a 1.4 M⊙ neutron star, we find the radius to be R_NS=12.2^{+1.5}_{-1.1} km, a significant improvement in precision over previous measurements. Incorporating an uncertainty on the distance to M13 relaxes the radius constraints slightly and we find R_NS=12.3^{+1.9}_{-1.7} km (for a 1.4M⊙ neutron star with a hydrogen atmosphere), which is still an improvement in precision over previous measurements, some of which do not consider distance uncertainty. We also discuss how the composition of the atmosphere affects the derived radius, finding that a helium atmosphere implies a significantly larger radius.

  4. The Betelgeuse Project: Constraints from Rotation

    NASA Astrophysics Data System (ADS)

    Diaz, Manuel; Nance, Sarafina; Sullivan, James; Wheeler, J. Craig

    2017-01-01

    In order to constrain the evolutionary state of the red supergiant Betelgeuse, we have produced a suite of models with ZAMS masses from 15 to 25 Msun in intervals of 1 Msun including the effects of rotation computed with the stellar evolutionary code MESA. For non--rotating models we find results that are similar to other work. It is somewhat difficult to find models that agree within 1 σ of the observed values of R, Teff and L, but modestly easy within 3 σ uncertainty. Incorporating the nominal observed rotational velocity, ~15 km/s, yields significantly different, and challenging, constraints. This velocity constraint is only matched when the models first approach the base of the red supergiant branch (RSB), having crossed the Hertzsprung gap, but not yet having ascended the RSB and most violate even generous error bars on R, Teff and L. Models at the tip of the RSB typically rotate at only ~0.1 km/s, independent of any reasonable choice of initial rotation. We discuss the possible uncertainties in our modeling and the observations, including the distance to Betelgeuse, the rotation velocity, and model parameters. We summarize various options to account for the rotational velocity and suggest that one possibility is that Betelgeuse merged with a companion star of about 1 Msun as it ascended the RSB, in the process producing the ring structure observed at about 7' away. A past coalescence would complicate attempts to understand the evolutionary history and future of Betelgeuse. To that end, we also present asteroseismology models with acoustic waves driven by inner convective regions that could elucidate the inner structure and evolutionary state.

  5. MSX-3D: a tool to validate 3D protein models using mass spectrometry.

    PubMed

    Heymann, Michaël; Paramelle, David; Subra, Gilles; Forest, Eric; Martinez, Jean; Geourjon, Christophe; Deléage, Gilbert

    2008-12-01

    The technique of chemical cross-linking followed by mass spectrometry has proven to bring valuable information about the protein structure and interactions between proteic subunits. It is an effective and efficient way to experimentally investigate some aspects of a protein structure when NMR and X-ray crystallography data are lacking. We introduce MSX-3D, a tool specifically geared to validate protein models using mass spectrometry. In addition to classical peptides identifications, it allows an interactive 3D visualization of the distance constraints derived from a cross-linking experiment. Freely available at http://proteomics-pbil.ibcp.fr

  6. Absorption features in the quasar HS 1603 + 3820 II. Distance to the absorber obtained from photoionisation modelling

    NASA Astrophysics Data System (ADS)

    Różańska, A.; Nikołajuk, M.; Czerny, B.; Dobrzycki, A.; Hryniewicz, K.; Bechtold, J.; Ebeling, H.

    2014-04-01

    We present the photoionisation modelling of the intrinsic absorber in the bright quasar HS 1603 + 3820. We constructed the broad-band spectral energy distribution using the optical/UV/X-ray observations from different instruments as inputs for the photoionisation calculations. The spectra from the Keck telescope show extremely high CIV to HI ratios, for the first absorber in system A, named A1. This value, together with high column density of CIV ion, place strong constraints on the photoionisation model. We used two photoionisation codes to derive the hydrogen number density at the cloud illuminated surface. By estimating bolometric luminosity of HS 1603 + 3820 using the typical formula for quasars, we calculated the distance to A1. We could find one photoionization solution, by assuming either a constant density cloud (which was modelled using CLOUDY), or a stratified cloud (which was modelled using TITAN), as well as the solar abundances. This model explained both the ionic column density of CIV and the high CIV to HI ratio. The location of A1 is 0.1 pc, and it is situated even closer to the nucleus than the possible location of the Broad Line Region in this object. The upper limit of the distance is sensitive to the adopted covering factor and the carbon abundance. Photoionisation modelling always prefers dense clouds with the number density n0 = 1010 - 1012 cm-3, which explains intrinsic absorption in HS 1603 + 3820. This number density is of the same order as that in the disk atmosphere at the implied distance of A1. Therefore, our results show that the disk wind that escapes from the outermost accretion disk atmosphere can build up dense absorber in quasars.

  7. The Evolution from Traditional to Online Professional Development: A Review

    ERIC Educational Resources Information Center

    Elliott, Joshua C.

    2017-01-01

    Online professional development offers opportunities for growth to teachers who may not be able to participate otherwise due to constraints. These constraints include, but are not limited to, time and travel distance. This document is a narrative review of relevant literature as it relates to the evolution of teacher professional development. This…

  8. Type Ia Supernova Distances at Redshift >1.5 from the Hubble Space Telescope Multi-cycle Treasury Programs: The Early Expansion Rate

    NASA Astrophysics Data System (ADS)

    Riess, Adam G.; Rodney, Steven A.; Scolnic, Daniel M.; Shafer, Daniel L.; Strolger, Louis-Gregory; Ferguson, Henry C.; Postman, Marc; Graur, Or; Maoz, Dan; Jha, Saurabh W.; Mobasher, Bahram; Casertano, Stefano; Hayden, Brian; Molino, Alberto; Hjorth, Jens; Garnavich, Peter M.; Jones, David O.; Kirshner, Robert P.; Koekemoer, Anton M.; Grogin, Norman A.; Brammer, Gabriel; Hemmati, Shoubaneh; Dickinson, Mark; Challis, Peter M.; Wolff, Schuyler; Clubb, Kelsey I.; Filippenko, Alexei V.; Nayyeri, Hooshang; U, Vivian; Koo, David C.; Faber, Sandra M.; Kocevski, Dale; Bradley, Larry; Coe, Dan

    2018-02-01

    We present an analysis of 15 Type Ia supernovae (SNe Ia) at redshift z> 1 (9 at 1.5< z< 2.3) recently discovered in the CANDELS and CLASH Multi-Cycle Treasury programs using WFC3 on the Hubble Space Telescope. We combine these SNe Ia with a new compilation of ∼1050 SNe Ia, jointly calibrated and corrected for simulated survey biases to produce accurate distance measurements. We present unbiased constraints on the expansion rate at six redshifts in the range 0.07< z< 1.5 based only on this combined SN Ia sample. The added leverage of our new sample at z> 1.5 leads to a factor of ∼3 improvement in the determination of the expansion rate at z = 1.5, reducing its uncertainty to ∼20%, a measurement of H(z=1.5)/{H}0 = {2.69}-0.52+0.86. We then demonstrate that these six derived expansion rate measurements alone provide a nearly identical characterization of dark energy as the full SN sample, making them an efficient compression of the SN Ia data. The new sample of SNe Ia at z> 1.5 usefully distinguishes between alternative cosmological models and unmodeled evolution of the SN Ia distance indicators, placing empirical limits on the latter. Finally, employing a realistic simulation of a potential Wide-Field Infrared Survey Telescope SN survey observing strategy, we forecast optimistic future constraints on the expansion rate from SNe Ia.

  9. Materials Production in Open and Distance Learning.

    ERIC Educational Resources Information Center

    Lockwood, Fred, Ed.

    This book contains 19 papers grouped in three sections that lead the reader through the process of planning, producing, and presenting materials in open and distance learning, based on experience in Great Britain. Following an overview by Roger Lewis, the Planning section contains the following six papers: "Resources and Constraints in Open…

  10. Challenges of Online Education in a Developing Country.

    ERIC Educational Resources Information Center

    Mashile, E. O.; Pretorius, F. J.

    2003-01-01

    Conducted a case study of efforts to progress with distance education in South Africa given the constraints of the country's digital divide. Results show that digital divide problems can undermine the provision of enhanced pedagogies in distance education programs, hampering the position of individuals of low socioeconomic status. (SLD)

  11. Unscreening Modified Gravity in the Matter Power Spectrum.

    PubMed

    Lombriser, Lucas; Simpson, Fergus; Mead, Alexander

    2015-06-26

    Viable modifications of gravity that may produce cosmic acceleration need to be screened in high-density regions such as the Solar System, where general relativity is well tested. Screening mechanisms also prevent strong anomalies in the large-scale structure and limit the constraints that can be inferred on these gravity models from cosmology. We find that by suppressing the contribution of the screened high-density regions in the matter power spectrum, allowing a greater contribution of unscreened low densities, modified gravity models can be more readily discriminated from the concordance cosmology. Moreover, by variation of density thresholds, degeneracies with other effects may be dealt with more adequately. Specializing to chameleon gravity as a worked example for screening in modified gravity, employing N-body simulations of f(R) models and the halo model of chameleon theories, we demonstrate the effectiveness of this method. We find that a percent-level measurement of the clipped power at k<0.3h/Mpc can yield constraints on chameleon models that are more stringent than what is inferred from Solar System tests or distance indicators in unscreened dwarf galaxies. Finally, we verify that our method is also applicable to the Vainshtein mechanism.

  12. Probability distributions of bed load particle velocities, accelerations, hop distances, and travel times informed by Jaynes's principle of maximum entropy

    USGS Publications Warehouse

    Furbish, David; Schmeeckle, Mark; Schumer, Rina; Fathel, Siobhan

    2016-01-01

    We describe the most likely forms of the probability distributions of bed load particle velocities, accelerations, hop distances, and travel times, in a manner that formally appeals to inferential statistics while honoring mechanical and kinematic constraints imposed by equilibrium transport conditions. The analysis is based on E. Jaynes's elaboration of the implications of the similarity between the Gibbs entropy in statistical mechanics and the Shannon entropy in information theory. By maximizing the information entropy of a distribution subject to known constraints on its moments, our choice of the form of the distribution is unbiased. The analysis suggests that particle velocities and travel times are exponentially distributed and that particle accelerations follow a Laplace distribution with zero mean. Particle hop distances, viewed alone, ought to be distributed exponentially. However, the covariance between hop distances and travel times precludes this result. Instead, the covariance structure suggests that hop distances follow a Weibull distribution. These distributions are consistent with high-resolution measurements obtained from high-speed imaging of bed load particle motions. The analysis brings us closer to choosing distributions based on our mechanical insight.

  13. Observational constraint on dynamical evolution of dark energy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gong, Yungui; Cai, Rong-Gen; Chen, Yun

    2010-01-01

    We use the Constitution supernova, the baryon acoustic oscillation, the cosmic microwave background, and the Hubble parameter data to analyze the evolution property of dark energy. We obtain different results when we fit different baryon acoustic oscillation data combined with the Constitution supernova data to the Chevallier-Polarski-Linder model. We find that the difference stems from the different values of Ω{sub m0}. We also fit the observational data to the model independent piecewise constant parametrization. Four redshift bins with boundaries at z = 0.22, 0.53, 0.85 and 1.8 were chosen for the piecewise constant parametrization of the equation of state parametermore » w(z) of dark energy. We find no significant evidence for evolving w(z). With the addition of the Hubble parameter, the constraint on the equation of state parameter at high redshift is improved by 70%. The marginalization of the nuisance parameter connected to the supernova distance modulus is discussed.« less

  14. Spatial effects in real networks: Measures, null models, and applications

    NASA Astrophysics Data System (ADS)

    Ruzzenenti, Franco; Picciolo, Francesco; Basosi, Riccardo; Garlaschelli, Diego

    2012-12-01

    Spatially embedded networks are shaped by a combination of purely topological (space-independent) and space-dependent formation rules. While it is quite easy to artificially generate networks where the relative importance of these two factors can be varied arbitrarily, it is much more difficult to disentangle these two architectural effects in real networks. Here we propose a solution to this problem, by introducing global and local measures of spatial effects that, through a comparison with adequate null models, effectively filter out the spurious contribution of nonspatial constraints. Our filtering allows us to consistently compare different embedded networks or different historical snapshots of the same network. As a challenging application we analyze the World Trade Web, whose topology is known to depend on geographic distances but is also strongly determined by nonspatial constraints (degree sequence or gross domestic product). Remarkably, we are able to detect weak but significant spatial effects both locally and globally in the network, showing that our method succeeds in retrieving spatial information even when nonspatial factors dominate. We finally relate our results to the economic literature on gravity models and trade globalization.

  15. The Problem of Hipparcos Distances to Open Clusters. II. Constraints from Nearby Field Theory. Report 2; ClustersConstraints from nearly Field Stars

    NASA Technical Reports Server (NTRS)

    Soderblom, David R.; King, Jeremy R.; Hanson, Robert B.; Jones, Burton F.; Fischer, Debra; Stauffer, John R.; Pinsonneault, Marc H.

    1998-01-01

    This paper examines the discrepancy between distances to nearby open clusters as determined by parallaxes from Hipparcos compared to traditional main-sequence fitting. The biggest difference is seen for the Pleiades, and our hypothesis is that if the Hipparcos distance to the Pleiades is correct, then similar subluminous zero-age main-sequence (ZAMS) stars should exist elsewhere, including in the immediate solar neighborhood. We examine a color-magnitude diagram of very young and nearby solar-type stars and show that none of them lie below the traditional ZAMS, despite the fact that the Hipparcos Pleiades parallax would place its members 0.3 mag below that ZAMS. We also present analyses and observations of solar-type stars that do lie below the ZAMS, and we show that they are subluminous because of low metallicity and that they have the kinematics of old stars.

  16. Modelisations et inversions tri-dimensionnelles en prospections gravimetrique et electrique

    NASA Astrophysics Data System (ADS)

    Boulanger, Olivier

    The aim of this thesis is the application of gravity and resistivity methods for mining prospecting. The objectives of the present study are: (1) to build a fast gravity inversion method to interpret surface data; (2) to develop a tool for modelling the electrical potential acquired at surface and in boreholes when the resistivity distribution is heterogeneous; and (3) to define and implement a stochastic inversion scheme allowing the estimation of the subsurface resistivity from electrical data. The first technique concerns the elaboration of a three dimensional (3D) inversion program allowing the interpretation of gravity data using a selection of constraints such as the minimum distance, the flatness, the smoothness and the compactness. These constraints are integrated in a Lagrangian formulation. A multi-grid technique is also implemented to resolve separately large and short gravity wavelengths. The subsurface in the survey area is divided into juxtaposed rectangular prismatic blocks. The problem is solved by calculating the model parameters, i.e. the densities of each block. Weights are given to each block depending on depth, a priori information on density, and density range allowed for the region under investigation. The present code is tested on synthetic data. Advantages and behaviour of each method are compared in the 3D reconstruction. Recovery of geometry (depth, size) and density distribution of the original model is dependent on the set of constraints used. The best combination of constraints experimented for multiple bodies seems to be flatness and minimum volume for multiple bodies. The inversion method is tested on real gravity data. The second tool developed in this thesis is a three-dimensional electrical resistivity modelling code to interpret surface and subsurface data. Based on the integral equation, it calculates the charge density caused by conductivity gradients at each interface of the mesh allowing an exact estimation of the potential. Modelling generates a huge matrix made of Green's functions which is stored by using the method of pyramidal compression. The third method consists to interpret electrical potential measurements from a non-linear geostatistical approach including new constraints. This method estimates an analytical covariance model for the resistivity parameters from the potential data. (Abstract shortened by UMI.)

  17. Spectral properties of blast-wave models of gamma-ray burst sources

    NASA Technical Reports Server (NTRS)

    Meszaros, P.; Rees, M. J.; Papathanassiou, H.

    1994-01-01

    We calculate the spectrum of blast-wave models of gamma-ray burst sources, for various assumptions about the magnetic field density and the relativistic particle acceleration efficiency. For a range of physically plausible models we find that the radiation efficiency is high and leads to nonthermal spectra with breaks at various energies comparable to those observed in the gamma-ray range. Radiation is also predicted at other wavebands, in particular at X-ray, optical/UV, and GeV/TeV energies. We discuss the spectra as a function of duration for three basic types of models, and for cosmological, halo, and galactic disk distances. We also evaluate the gamma-ray fluences and the spectral characteristics for a range of external densities. Impulsive burst models at cosmological distances can satisfy the conventional X-ray paucity constraint S(sub x)/S(sub gamma)less than a few percent over a wide range of durations, but galactic models can do so only for bursts shorter than a few seconds, unless additional assumptions are made. The emissivity is generally larger for bursts in a denser external environment, with the efficiency increasing up to the point where all the energy input is radiated away.

  18. Dynamics and phenomenology of higher order gravity cosmological models

    NASA Astrophysics Data System (ADS)

    Moldenhauer, Jacob Andrew

    2010-10-01

    I present here some new results about a systematic approach to higher-order gravity (HOG) cosmological models. The HOG models are derived from curvature invariants that are more general than the Einstein-Hilbert action. Some of the models exhibit late-time cosmic acceleration without the need for dark energy and fit some current observations. The open question is that there are an infinite number of invariants that one could select, and many of the published papers have stressed the need to find a systematic approach that will allow one to study methodically the various possibilities. We explore a new connection that we made between theorems from the theory of invariants in general relativity and these cosmological models. In summary, the theorems demonstrate that curvature invariants are not all independent from each other and that for a given Ricci Segre type and Petrov type (symmetry classification) of the space-time, there exists a complete minimal set of independent invariants (a basis) in terms of which all the other invariants can be expressed. As an immediate consequence of the proposed approach, the number of invariants to consider is dramatically reduced from infinity to four invariants in the worst case and to only two invariants in the cases of interest, including all Friedmann-Lemaitre-Robertson-Walker metrics. We derive models that pass stability and physical acceptability conditions. We derive dynamical equations and phase portrait analyses that show the promise of the systematic approach. We consider observational constraints from magnitude-redshift Supernovae Type Ia data, distance to the last scattering surface of the Cosmic Microwave Background radiation, and Baryon Acoustic Oscillations. We put observational constraints on general HOG models. We constrain different forms of the Gauss-Bonnet, f(G), modified gravity models with these observations. We show some of these models pass solar system tests. We seek to find models that pass physical and observational constraints and give fits to the data that are almost as good as those of the standard Lambda-Cold-Dark-Matter model. Finding accelerating HOG models with late-time acceleration that pass physical acceptability conditions, solar system tests, and cosmological constraints will constitute serious contenders to explain cosmic acceleration.

  19. Geometric constraints for shape and topology optimization in architectural design

    NASA Astrophysics Data System (ADS)

    Dapogny, Charles; Faure, Alexis; Michailidis, Georgios; Allaire, Grégoire; Couvelas, Agnes; Estevez, Rafael

    2017-06-01

    This work proposes a shape and topology optimization framework oriented towards conceptual architectural design. A particular emphasis is put on the possibility for the user to interfere on the optimization process by supplying information about his personal taste. More precisely, we formulate three novel constraints on the geometry of shapes; while the first two are mainly related to aesthetics, the third one may also be used to handle several fabrication issues that are of special interest in the device of civil structures. The common mathematical ingredient to all three models is the signed distance function to a domain, and its sensitivity analysis with respect to perturbations of this domain; in the present work, this material is extended to the case where the ambient space is equipped with an anisotropic metric tensor. Numerical examples are discussed in two and three space dimensions.

  20. INDUCED SCATTERING LIMITS ON FAST RADIO BURSTS FROM STELLAR CORONAE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lyubarsky, Yuri; Ostrovska, Sofiya

    2016-02-10

    The origin of fast radio bursts remains a puzzle. Suggestions have been made that they are produced within the Earth’s atmosphere, in stellar coronae, in other galaxies, or at cosmological distances. If they are extraterrestrial, the implied brightness temperature is very high, and therefore the induced scattering places constraints on possible models. In this paper, constraints are obtained on flares from coronae of nearby stars. It is shown that the radio pulses with the observed power could not be generated if the plasma density within and in the nearest vicinity of the source is as high as is necessary tomore » provide the observed dispersion measure. However, one cannot exclude the possibility that the pulses are generated within a bubble with a very low density and pass through the dense plasma only in the outer corona.« less

  1. Estimating true evolutionary distances under the DCJ model.

    PubMed

    Lin, Yu; Moret, Bernard M E

    2008-07-01

    Modern techniques can yield the ordering and strandedness of genes on each chromosome of a genome; such data already exists for hundreds of organisms. The evolutionary mechanisms through which the set of the genes of an organism is altered and reordered are of great interest to systematists, evolutionary biologists, comparative genomicists and biomedical researchers. Perhaps the most basic concept in this area is that of evolutionary distance between two genomes: under a given model of genomic evolution, how many events most likely took place to account for the difference between the two genomes? We present a method to estimate the true evolutionary distance between two genomes under the 'double-cut-and-join' (DCJ) model of genome rearrangement, a model under which a single multichromosomal operation accounts for all genomic rearrangement events: inversion, transposition, translocation, block interchange and chromosomal fusion and fission. Our method relies on a simple structural characterization of a genome pair and is both analytically and computationally tractable. We provide analytical results to describe the asymptotic behavior of genomes under the DCJ model, as well as experimental results on a wide variety of genome structures to exemplify the very high accuracy (and low variance) of our estimator. Our results provide a tool for accurate phylogenetic reconstruction from multichromosomal gene rearrangement data as well as a theoretical basis for refinements of the DCJ model to account for biological constraints. All of our software is available in source form under GPL at http://lcbb.epfl.ch.

  2. Simulation analysis of adaptive cruise prediction control

    NASA Astrophysics Data System (ADS)

    Zhang, Li; Cui, Sheng Min

    2017-09-01

    Predictive control is suitable for multi-variable and multi-constraint system control.In order to discuss the effect of predictive control on the vehicle longitudinal motion, this paper establishes the expected spacing model by combining variable pitch spacing and the of safety distance strategy. The model predictive control theory and the optimization method based on secondary planning are designed to obtain and track the best expected acceleration trajectory quickly. Simulation models are established including predictive and adaptive fuzzy control. Simulation results show that predictive control can realize the basic function of the system while ensuring the safety. The application of predictive and fuzzy adaptive algorithm in cruise condition indicates that the predictive control effect is better.

  3. A Pragmatic LDI Operational Network Model for Pakistan

    NASA Astrophysics Data System (ADS)

    Sheikh, Roshan; Mirza, Zahir Abbas

    2008-10-01

    This paper describes some common components of contemporary designs for the Long Distance & International (LDI) License in Pakistan and identifies critical aspects needed to implement a commercial LDI network in any developing country like Pakistan. An extensive study is carried out to evaluate various methods through which a carrier can receive and transmit voice traffic and identify their respective merits and demerits. Deficiencies which can harm the growth of telecom market in Pakistan and which require redress by the Pakistan Telecommunication Authority (PTA) are highlighted. A pragmatic model is proposed which takes into consideration, the constraints of Pakistan Telecommunication market. The paper concludes that the proposed model be incorporated with specific suggestions and economic justifications.

  4. Distance Metric Learning via Iterated Support Vector Machines.

    PubMed

    Zuo, Wangmeng; Wang, Faqiang; Zhang, David; Lin, Liang; Huang, Yuchi; Meng, Deyu; Zhang, Lei

    2017-07-11

    Distance metric learning aims to learn from the given training data a valid distance metric, with which the similarity between data samples can be more effectively evaluated for classification. Metric learning is often formulated as a convex or nonconvex optimization problem, while most existing methods are based on customized optimizers and become inefficient for large scale problems. In this paper, we formulate metric learning as a kernel classification problem with the positive semi-definite constraint, and solve it by iterated training of support vector machines (SVMs). The new formulation is easy to implement and efficient in training with the off-the-shelf SVM solvers. Two novel metric learning models, namely Positive-semidefinite Constrained Metric Learning (PCML) and Nonnegative-coefficient Constrained Metric Learning (NCML), are developed. Both PCML and NCML can guarantee the global optimality of their solutions. Experiments are conducted on general classification, face verification and person re-identification to evaluate our methods. Compared with the state-of-the-art approaches, our methods can achieve comparable classification accuracy and are efficient in training.

  5. An assessment of energy efficiency based on environmental constraints and its influencing factors in China.

    PubMed

    Chen, Yao; Xu, Jing-Ting

    2018-05-03

    The super-efficiency directional distance function (DDF) with data envelopment analysis (DEA) model (SEDDF-DEA) is more facilitative than to increase traditional method as a rise of energy efficiency in China, which is currently important energy development from Asia-pacific region countries. SEDDF-DEA is promoted as sustained total-factor energy efficiency (TFEE), value added outputs, and Malmquist-Luenberger productivity index (MLPI) to otherwise thorny environmental energy productivity problems with environmental constraint to concrete the means of regression model. This paper assesses the energy efficiency under environmental constraints using panel data covering the years of 2000-2015 in China. Considering the environmental constraints, the results showed that the average TFEE of the whole country followed an upward trend after 2006. The average MLPI score for the whole country increased by 10.57% during 2005-2010, which was mainly due to the progress made in developing and applying environmental technologies. The TFEE of the whole nation was promoted by the accumulation of capital stock, while it was suppressed by excessive production in secondary industries and foreign investment. The primary challenge for the northeast of China is to strengthen industrial transformation and upgrade traditional industries, as well as adjusting the economy and energy structure. The eastern and central regions of the country need to exploit clean- or low-energy industry to improve inefficiencies due to excessive consumption. The western region of China needs to implement renewable energy strategies to promote regional development.

  6. Distance Learning as an Effective Tool for Medical Interpreting Training in Turkey

    ERIC Educational Resources Information Center

    Güven, Mine

    2014-01-01

    This study addresses the need for trained medical interpreters in various local/ethnic languages especially at public health institutions in Turkey, and argues that distance learning would be an effective tool for medical interpreting training, given the particular constraints of the situation. Designed to meet the respective needs of different…

  7. The Potential Impact of Computer-Aided Assessment Technology in Higher Education

    ERIC Educational Resources Information Center

    Tshibalo, A. E.

    2007-01-01

    Distance learning generally separates students from educators, and demands that interventions be put in place to counter the constraints that this distance poses to learners and educators. Furthermore "Increased number of students in Higher Education and the corresponding increase in time spent by staff on assessment has encouraged interest…

  8. Interdependence of Roles, Role Rotation, and Sense of Community in an Online Course

    ERIC Educational Resources Information Center

    Jiang, Wenting

    2017-01-01

    More and more educational institutions are moving towards online distance learning. Although asynchronous online learning overcomes the constraints of time, place and pace, online distance learners feel isolated due to the lack of real-time communications. One possible solution for overcoming this sense of isolation is regulating student online…

  9. Reconstruction of forest geometries from terrestrial laser scanning point clouds for canopy radiative transfer modelling

    NASA Astrophysics Data System (ADS)

    Bremer, Magnus; Schmidtner, Korbinian; Rutzinger, Martin

    2015-04-01

    The architecture of forest canopies is a key parameter for forest ecological issues helping to model the variability of wood biomass and foliage in space and time. In order to understand the nature of subpixel effects of optical space-borne sensors with coarse spatial resolution, hypothetical 3D canopy models are widely used for the simulation of radiative transfer in forests. Thereby, radiation is traced through the atmosphere and canopy geometries until it reaches the optical sensor. For a realistic simulation scene we decompose terrestrial laser scanning point cloud data of leaf-off larch forest plots in the Austrian Alps and reconstruct detailed model ready input data for radiative transfer simulations. The point clouds are pre-classified into primitive classes using Principle Component Analysis (PCA) using scale adapted radius neighbourhoods. Elongated point structures are extracted as tree trunks. The tree trunks are used as seeds for a Dijkstra-growing procedure, in order to obtain single tree segmentation in the interlinked canopies. For the optimized reconstruction of branching architectures as vector models, point cloud skeletonisation is used in combination with an iterative Dijkstra-growing and by applying distance constraints. This allows conducting a hierarchical reconstruction preferring the tree trunk and higher order branches and avoiding over-skeletonization effects. Based on the reconstructed branching architectures, larch needles are modelled based on the hierarchical level of branches and the geometrical openness of the canopy. For radiative transfer simulations, branch architectures are used as mesh geometries representing branches as cylindrical pipes. Needles are either used as meshes or as voxel-turbids. The presented workflow allows an automatic classification and single tree segmentation in interlinked canopies. The iterative Dijkstra-growing using distance constraints generated realistic reconstruction results. As the mesh representation of branches proved to be sufficient for the simulation approach, the modelling of huge amounts of needles is much more efficient in voxel-turbid representation.

  10. Liver segmentation from CT images using a sparse priori statistical shape model (SP-SSM).

    PubMed

    Wang, Xuehu; Zheng, Yongchang; Gan, Lan; Wang, Xuan; Sang, Xinting; Kong, Xiangfeng; Zhao, Jie

    2017-01-01

    This study proposes a new liver segmentation method based on a sparse a priori statistical shape model (SP-SSM). First, mark points are selected in the liver a priori model and the original image. Then, the a priori shape and its mark points are used to obtain a dictionary for the liver boundary information. Second, the sparse coefficient is calculated based on the correspondence between mark points in the original image and those in the a priori model, and then the sparse statistical model is established by combining the sparse coefficients and the dictionary. Finally, the intensity energy and boundary energy models are built based on the intensity information and the specific boundary information of the original image. Then, the sparse matching constraint model is established based on the sparse coding theory. These models jointly drive the iterative deformation of the sparse statistical model to approximate and accurately extract the liver boundaries. This method can solve the problems of deformation model initialization and a priori method accuracy using the sparse dictionary. The SP-SSM can achieve a mean overlap error of 4.8% and a mean volume difference of 1.8%, whereas the average symmetric surface distance and the root mean square symmetric surface distance can reach 0.8 mm and 1.4 mm, respectively.

  11. RNA unrestrained molecular dynamics ensemble improves agreement with experimental NMR data compared to single static structure: a test case

    NASA Astrophysics Data System (ADS)

    Beckman, Robert A.; Moreland, David; Louise-May, Shirley; Humblet, Christine

    2006-05-01

    Nuclear magnetic resonance (NMR) provides structural and dynamic information reflecting an average, often non-linear, of multiple solution-state conformations. Therefore, a single optimized structure derived from NMR refinement may be misleading if the NMR data actually result from averaging of distinct conformers. It is hypothesized that a conformational ensemble generated by a valid molecular dynamics (MD) simulation should be able to improve agreement with the NMR data set compared with the single optimized starting structure. Using a model system consisting of two sequence-related self-complementary ribonucleotide octamers for which NMR data was available, 0.3 ns particle mesh Ewald MD simulations were performed in the AMBER force field in the presence of explicit water and counterions. Agreement of the averaged properties of the molecular dynamics ensembles with NMR data such as homonuclear proton nuclear Overhauser effect (NOE)-based distance constraints, homonuclear proton and heteronuclear 1H-31P coupling constant ( J) data, and qualitative NMR information on hydrogen bond occupancy, was systematically assessed. Despite the short length of the simulation, the ensemble generated from it agreed with the NMR experimental constraints more completely than the single optimized NMR structure. This suggests that short unrestrained MD simulations may be of utility in interpreting NMR results. As expected, a 0.5 ns simulation utilizing a distance dependent dielectric did not improve agreement with the NMR data, consistent with its inferior exploration of conformational space as assessed by 2-D RMSD plots. Thus, ability to rapidly improve agreement with NMR constraints may be a sensitive diagnostic of the MD methods themselves.

  12. Three Corner Sat Communications System

    NASA Technical Reports Server (NTRS)

    Anderson, Bobby; Horan, Stephen

    2000-01-01

    Three Corner Satellite is a constellation of three nanosatellites designed and built by students. New Mexico State University has taken on the design of the communications system for this constellation. The system includes the forward link, return link, and the crosslink. Due to size, mass, power, and financial constraints, we must design a small, light, power efficient, and inexpensive communications system. This thesis presents the design of a radio system to accomplish the data transmission requirements in light of the system constraints. In addition to the hardware design, the operational commands needed by the satellite's on-board computer to control and communicate with the communications hardware will be presented. In order for the hardware to communicate with the ground stations, we will examine the link budgets derived from the radiated power of the transmitters, link distance, data modulation, and data rate for each link. The antenna design for the constellation is analyzed using software and testing the physical antennas on a model satellite. After the analysis and testing, a combination of different systems will meet and exceed the requirements and constraints of the Three Corner Satellite constellation.

  13. Feasible Path Generation Using Bezier Curves for Car-Like Vehicle

    NASA Astrophysics Data System (ADS)

    Latip, Nor Badariyah Abdul; Omar, Rosli

    2017-08-01

    When planning a collision-free path for an autonomous vehicle, the main criteria that have to be considered are the shortest distance, lower computation time and completeness, i.e. a path can be found if one exists. Besides that, a feasible path for the autonomous vehicle is also crucial to guarantee that the vehicle can reach the target destination considering its kinematic constraints such as non-holonomic and minimum turning radius. In order to address these constraints, Bezier curves is applied. In this paper, Bezier curves are modeled and simulated using Matlab software and the feasibility of the resulting path is analyzed. Bezier curve is derived from a piece-wise linear pre-planned path. It is found that the Bezier curves has the capability of making the planned path feasible and could be embedded in a path planning algorithm for an autonomous vehicle with kinematic constraints. It is concluded that the length of segments of the pre-planned path have to be greater than a nominal value, derived from the vehicle wheelbase, maximum steering angle and maximum speed to ensure the path for the autonomous car is feasible.

  14. Distance restraints from crosslinking mass spectrometry: mining a molecular dynamics simulation database to evaluate lysine-lysine distances.

    PubMed

    Merkley, Eric D; Rysavy, Steven; Kahraman, Abdullah; Hafen, Ryan P; Daggett, Valerie; Adkins, Joshua N

    2014-06-01

    Integrative structural biology attempts to model the structures of protein complexes that are challenging or intractable by classical structural methods (due to size, dynamics, or heterogeneity) by combining computational structural modeling with data from experimental methods. One such experimental method is chemical crosslinking mass spectrometry (XL-MS), in which protein complexes are crosslinked and characterized using liquid chromatography-mass spectrometry to pinpoint specific amino acid residues in close structural proximity. The commonly used lysine-reactive N-hydroxysuccinimide ester reagents disuccinimidylsuberate (DSS) and bis(sulfosuccinimidyl)suberate (BS(3) ) have a linker arm that is 11.4 Å long when fully extended, allowing Cα (alpha carbon of protein backbone) atoms of crosslinked lysine residues to be up to ∼24 Å apart. However, XL-MS studies on proteins of known structure frequently report crosslinks that exceed this distance. Typically, a tolerance of ∼3 Å is added to the theoretical maximum to account for this observation, with limited justification for the chosen value. We used the Dynameomics database, a repository of high-quality molecular dynamics simulations of 807 proteins representative of diverse protein folds, to investigate the relationship between lysine-lysine distances in experimental starting structures and in simulation ensembles. We conclude that for DSS/BS(3), a distance constraint of 26-30 Å between Cα atoms is appropriate. This analysis provides a theoretical basis for the widespread practice of adding a tolerance to the crosslinker length when comparing XL-MS results to structures or in modeling. We also discuss the comparison of XL-MS results to MD simulations and known structures as a means to test and validate experimental XL-MS methods. © 2014 The Protein Society.

  15. Deep Multimodal Distance Metric Learning Using Click Constraints for Image Ranking.

    PubMed

    Yu, Jun; Yang, Xiaokang; Gao, Fei; Tao, Dacheng

    2017-12-01

    How do we retrieve images accurately? Also, how do we rank a group of images precisely and efficiently for specific queries? These problems are critical for researchers and engineers to generate a novel image searching engine. First, it is important to obtain an appropriate description that effectively represent the images. In this paper, multimodal features are considered for describing images. The images unique properties are reflected by visual features, which are correlated to each other. However, semantic gaps always exist between images visual features and semantics. Therefore, we utilize click feature to reduce the semantic gap. The second key issue is learning an appropriate distance metric to combine these multimodal features. This paper develops a novel deep multimodal distance metric learning (Deep-MDML) method. A structured ranking model is adopted to utilize both visual and click features in distance metric learning (DML). Specifically, images and their related ranking results are first collected to form the training set. Multimodal features, including click and visual features, are collected with these images. Next, a group of autoencoders is applied to obtain initially a distance metric in different visual spaces, and an MDML method is used to assign optimal weights for different modalities. Next, we conduct alternating optimization to train the ranking model, which is used for the ranking of new queries with click features. Compared with existing image ranking methods, the proposed method adopts a new ranking model to use multimodal features, including click features and visual features in DML. We operated experiments to analyze the proposed Deep-MDML in two benchmark data sets, and the results validate the effects of the method.

  16. Distance restraints from crosslinking mass spectrometry: Mining a molecular dynamics simulation database to evaluate lysine–lysine distances

    PubMed Central

    Merkley, Eric D; Rysavy, Steven; Kahraman, Abdullah; Hafen, Ryan P; Daggett, Valerie; Adkins, Joshua N

    2014-01-01

    Integrative structural biology attempts to model the structures of protein complexes that are challenging or intractable by classical structural methods (due to size, dynamics, or heterogeneity) by combining computational structural modeling with data from experimental methods. One such experimental method is chemical crosslinking mass spectrometry (XL-MS), in which protein complexes are crosslinked and characterized using liquid chromatography-mass spectrometry to pinpoint specific amino acid residues in close structural proximity. The commonly used lysine-reactive N-hydroxysuccinimide ester reagents disuccinimidylsuberate (DSS) and bis(sulfosuccinimidyl)suberate (BS3) have a linker arm that is 11.4 Å long when fully extended, allowing Cα (alpha carbon of protein backbone) atoms of crosslinked lysine residues to be up to ∼24 Å apart. However, XL-MS studies on proteins of known structure frequently report crosslinks that exceed this distance. Typically, a tolerance of ∼3 Å is added to the theoretical maximum to account for this observation, with limited justification for the chosen value. We used the Dynameomics database, a repository of high-quality molecular dynamics simulations of 807 proteins representative of diverse protein folds, to investigate the relationship between lysine–lysine distances in experimental starting structures and in simulation ensembles. We conclude that for DSS/BS3, a distance constraint of 26–30 Å between Cα atoms is appropriate. This analysis provides a theoretical basis for the widespread practice of adding a tolerance to the crosslinker length when comparing XL-MS results to structures or in modeling. We also discuss the comparison of XL-MS results to MD simulations and known structures as a means to test and validate experimental XL-MS methods. PMID:24639379

  17. Defining an essence of structure determining residue contacts in proteins.

    PubMed

    Sathyapriya, R; Duarte, Jose M; Stehr, Henning; Filippis, Ioannis; Lappe, Michael

    2009-12-01

    The network of native non-covalent residue contacts determines the three-dimensional structure of a protein. However, not all contacts are of equal structural significance, and little knowledge exists about a minimal, yet sufficient, subset required to define the global features of a protein. Characterisation of this "structural essence" has remained elusive so far: no algorithmic strategy has been devised to-date that could outperform a random selection in terms of 3D reconstruction accuracy (measured as the Ca RMSD). It is not only of theoretical interest (i.e., for design of advanced statistical potentials) to identify the number and nature of essential native contacts-such a subset of spatial constraints is very useful in a number of novel experimental methods (like EPR) which rely heavily on constraint-based protein modelling. To derive accurate three-dimensional models from distance constraints, we implemented a reconstruction pipeline using distance geometry. We selected a test-set of 12 protein structures from the four major SCOP fold classes and performed our reconstruction analysis. As a reference set, series of random subsets (ranging from 10% to 90% of native contacts) are generated for each protein, and the reconstruction accuracy is computed for each subset. We have developed a rational strategy, termed "cone-peeling" that combines sequence features and network descriptors to select minimal subsets that outperform the reference sets. We present, for the first time, a rational strategy to derive a structural essence of residue contacts and provide an estimate of the size of this minimal subset. Our algorithm computes sparse subsets capable of determining the tertiary structure at approximately 4.8 A Ca RMSD with as little as 8% of the native contacts (Ca-Ca and Cb-Cb). At the same time, a randomly chosen subset of native contacts needs about twice as many contacts to reach the same level of accuracy. This "structural essence" opens new avenues in the fields of structure prediction, empirical potentials and docking.

  18. Defining an Essence of Structure Determining Residue Contacts in Proteins

    PubMed Central

    Sathyapriya, R.; Duarte, Jose M.; Stehr, Henning; Filippis, Ioannis; Lappe, Michael

    2009-01-01

    The network of native non-covalent residue contacts determines the three-dimensional structure of a protein. However, not all contacts are of equal structural significance, and little knowledge exists about a minimal, yet sufficient, subset required to define the global features of a protein. Characterisation of this “structural essence” has remained elusive so far: no algorithmic strategy has been devised to-date that could outperform a random selection in terms of 3D reconstruction accuracy (measured as the Ca RMSD). It is not only of theoretical interest (i.e., for design of advanced statistical potentials) to identify the number and nature of essential native contacts—such a subset of spatial constraints is very useful in a number of novel experimental methods (like EPR) which rely heavily on constraint-based protein modelling. To derive accurate three-dimensional models from distance constraints, we implemented a reconstruction pipeline using distance geometry. We selected a test-set of 12 protein structures from the four major SCOP fold classes and performed our reconstruction analysis. As a reference set, series of random subsets (ranging from 10% to 90% of native contacts) are generated for each protein, and the reconstruction accuracy is computed for each subset. We have developed a rational strategy, termed “cone-peeling” that combines sequence features and network descriptors to select minimal subsets that outperform the reference sets. We present, for the first time, a rational strategy to derive a structural essence of residue contacts and provide an estimate of the size of this minimal subset. Our algorithm computes sparse subsets capable of determining the tertiary structure at approximately 4.8 Å Ca RMSD with as little as 8% of the native contacts (Ca-Ca and Cb-Cb). At the same time, a randomly chosen subset of native contacts needs about twice as many contacts to reach the same level of accuracy. This “structural essence” opens new avenues in the fields of structure prediction, empirical potentials and docking. PMID:19997489

  19. Efficient and Scalable Graph Similarity Joins in MapReduce

    PubMed Central

    Chen, Yifan; Zhang, Weiming; Tang, Jiuyang

    2014-01-01

    Along with the emergence of massive graph-modeled data, it is of great importance to investigate graph similarity joins due to their wide applications for multiple purposes, including data cleaning, and near duplicate detection. This paper considers graph similarity joins with edit distance constraints, which return pairs of graphs such that their edit distances are no larger than a given threshold. Leveraging the MapReduce programming model, we propose MGSJoin, a scalable algorithm following the filtering-verification framework for efficient graph similarity joins. It relies on counting overlapping graph signatures for filtering out nonpromising candidates. With the potential issue of too many key-value pairs in the filtering phase, spectral Bloom filters are introduced to reduce the number of key-value pairs. Furthermore, we integrate the multiway join strategy to boost the verification, where a MapReduce-based method is proposed for GED calculation. The superior efficiency and scalability of the proposed algorithms are demonstrated by extensive experimental results. PMID:25121135

  20. Efficient and scalable graph similarity joins in MapReduce.

    PubMed

    Chen, Yifan; Zhao, Xiang; Xiao, Chuan; Zhang, Weiming; Tang, Jiuyang

    2014-01-01

    Along with the emergence of massive graph-modeled data, it is of great importance to investigate graph similarity joins due to their wide applications for multiple purposes, including data cleaning, and near duplicate detection. This paper considers graph similarity joins with edit distance constraints, which return pairs of graphs such that their edit distances are no larger than a given threshold. Leveraging the MapReduce programming model, we propose MGSJoin, a scalable algorithm following the filtering-verification framework for efficient graph similarity joins. It relies on counting overlapping graph signatures for filtering out nonpromising candidates. With the potential issue of too many key-value pairs in the filtering phase, spectral Bloom filters are introduced to reduce the number of key-value pairs. Furthermore, we integrate the multiway join strategy to boost the verification, where a MapReduce-based method is proposed for GED calculation. The superior efficiency and scalability of the proposed algorithms are demonstrated by extensive experimental results.

  1. NuSTAR AND Swift Observations of the Very High State in GX 339-4: Weighing the Black Hole With X-Rays

    NASA Technical Reports Server (NTRS)

    Parker, M. L.; Tomsick, J. A.; Kennea, J. A.; Miller, J. M.; Harrison, F. A.; Barret, D.; Boggs, S. E.; Christensen, F. E.; Craig, W. W.; Fabian, A. C.; hide

    2016-01-01

    We present results from spectral fitting of the very high state of GX339-4 with Nuclear Spectroscopic Telescope Array (NuSTAR) and Swift. We use relativistic reflection modeling to measure the spin of the black hole and inclination of the inner disk and find a spin of a = 0.95+0.08/-0.02 and inclination of 30deg +/- 1deg (statistical errors). These values agree well with previous results from reflection modeling. With the exceptional sensitivity of NuSTAR at the high-energy side of the disk spectrum, we are able to constrain multiple physical parameters simultaneously using continuum fitting. By using the constraints from reflection as input for the continuum fitting method, we invert the conventional fitting procedure to estimate the mass and distance of GX 339-4 using just the X-ray spectrum, finding a mass of 9.0+1.6/-1.2 Stellar Mass and distance of 8.4 +/- 0.9 kpc (statistical errors).

  2. Insight to the express transport network

    NASA Astrophysics Data System (ADS)

    Yang, Hua; Nie, Yuchao; Zhang, Hongbin; Di, Zengru; Fan, Ying

    2009-09-01

    The express delivery industry is developing rapidly in recent years and has attracted attention in many fields. Express shipment service requires that parcels be delivered in a limited time with a low operation cost, which requests a high level and efficient express transport network (ETN). The ETN is constructed based on the public transport networks, especially the airline network. It is similar to the airline network in some aspects, while it has its own feature. With the complex network theory, the topological properties of the ETN are analyzed deeply. We find that the ETN has the small-world property, with disassortative mixing behavior and rich club phenomenon. It also shows difference from the airline network in some features, such as edge density and average shortest path. Analysis on the corresponding distance-weighted network shows that the distance distribution displays a truncated power-law behavior. At last, an evolving model, which takes both geographical constraint and preference attachment into account, is proposed. The model shows similar properties with the empirical results.

  3. Distance matrix-based approach to protein structure prediction.

    PubMed

    Kloczkowski, Andrzej; Jernigan, Robert L; Wu, Zhijun; Song, Guang; Yang, Lei; Kolinski, Andrzej; Pokarowski, Piotr

    2009-03-01

    Much structural information is encoded in the internal distances; a distance matrix-based approach can be used to predict protein structure and dynamics, and for structural refinement. Our approach is based on the square distance matrix D = [r(ij)(2)] containing all square distances between residues in proteins. This distance matrix contains more information than the contact matrix C, that has elements of either 0 or 1 depending on whether the distance r (ij) is greater or less than a cutoff value r (cutoff). We have performed spectral decomposition of the distance matrices D = sigma lambda(k)V(k)V(kT), in terms of eigenvalues lambda kappa and the corresponding eigenvectors v kappa and found that it contains at most five nonzero terms. A dominant eigenvector is proportional to r (2)--the square distance of points from the center of mass, with the next three being the principal components of the system of points. By predicting r (2) from the sequence we can approximate a distance matrix of a protein with an expected RMSD value of about 7.3 A, and by combining it with the prediction of the first principal component we can improve this approximation to 4.0 A. We can also explain the role of hydrophobic interactions for the protein structure, because r is highly correlated with the hydrophobic profile of the sequence. Moreover, r is highly correlated with several sequence profiles which are useful in protein structure prediction, such as contact number, the residue-wise contact order (RWCO) or mean square fluctuations (i.e. crystallographic temperature factors). We have also shown that the next three components are related to spatial directionality of the secondary structure elements, and they may be also predicted from the sequence, improving overall structure prediction. We have also shown that the large number of available HIV-1 protease structures provides a remarkable sampling of conformations, which can be viewed as direct structural information about the dynamics. After structure matching, we apply principal component analysis (PCA) to obtain the important apparent motions for both bound and unbound structures. There are significant similarities between the first few key motions and the first few low-frequency normal modes calculated from a static representative structure with an elastic network model (ENM) that is based on the contact matrix C (related to D), strongly suggesting that the variations among the observed structures and the corresponding conformational changes are facilitated by the low-frequency, global motions intrinsic to the structure. Similarities are also found when the approach is applied to an NMR ensemble, as well as to atomic molecular dynamics (MD) trajectories. Thus, a sufficiently large number of experimental structures can directly provide important information about protein dynamics, but ENM can also provide a similar sampling of conformations. Finally, we use distance constraints from databases of known protein structures for structure refinement. We use the distributions of distances of various types in known protein structures to obtain the most probable ranges or the mean-force potentials for the distances. We then impose these constraints on structures to be refined or include the mean-force potentials directly in the energy minimization so that more plausible structural models can be built. This approach has been successfully used by us in 2006 in the CASPR structure refinement (http://predictioncenter.org/caspR).

  4. The utility of protein structure as a predictor of site-wise dN/dS varies widely among HIV-1 proteins.

    PubMed

    Meyer, Austin G; Wilke, Claus O

    2015-10-06

    Protein structure acts as a general constraint on the evolution of viral proteins. One widely recognized structural constraint explaining evolutionary variation among sites is the relative solvent accessibility (RSA) of residues in the folded protein. In influenza virus, the distance from functional sites has been found to explain an additional portion of the evolutionary variation in the external antigenic proteins. However, to what extent RSA and distance from a reference site in the protein can be used more generally to explain protein adaptation in other viruses and in the different proteins of any given virus remains an open question. To address this question, we have carried out an analysis of the distribution and structural predictors of site-wise dN/dS in HIV-1. Our results indicate that the distribution of dN/dS in HIV follows a smooth gamma distribution, with no special enrichment or depletion of sites with dN/dS at or above one. The variation in dN/dS can be partially explained by RSA and distance from a reference site in the protein, but these structural constraints do not act uniformly among the different HIV-1 proteins. Structural constraints are highly predictive in just one of the three enzymes and one of three structural proteins in HIV-1. For these two proteins, the protease enzyme and the gp120 structural protein, structure explains between 30 and 40% of the variation in dN/dS. Finally, for the gp120 protein of the receptor-binding complex, we also find that glycosylation sites explain just 2% of the variation in dN/dS and do not explain gp120 evolution independently of either RSA or distance from the apical surface. © 2015 The Author(s).

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dhawan, Suhail; Goobar, Ariel; Mörtsell, Edvard

    Recent re-calibration of the Type Ia supernova (SNe Ia) magnitude-redshift relation combined with cosmic microwave background (CMB) and baryon acoustic oscillation (BAO) data have provided excellent constraints on the standard cosmological model. Here, we examine particular classes of alternative cosmologies, motivated by various physical mechanisms, e.g. scalar fields, modified gravity and phase transitions to test their consistency with observations of SNe Ia and the ratio of the angular diameter distances from the CMB and BAO. Using a model selection criterion for a relative comparison of the models (the Bayes Factor), we find moderate to strong evidence that the data prefermore » flat ΛCDM over models invoking a thawing behaviour of the quintessence scalar field. However, some exotic models like the growing neutrino mass cosmology and vacuum metamorphosis still present acceptable evidence values. The bimetric gravity model with only the linear interaction term as well as a simplified Galileon model can be ruled out by the combination of SNe Ia and CMB/BAO datasets whereas the model with linear and quadratic interaction terms has a comparable evidence value to standard ΛCDM. Thawing models are found to have significantly poorer evidence compared to flat ΛCDM cosmology under the assumption that the CMB compressed likelihood provides an adequate description for these non-standard cosmologies. We also present estimates for constraints from future data and find that geometric probes from oncoming surveys can put severe limits on non-standard cosmological models.« less

  6. The UBIRIS.v2: a database of visible wavelength iris images captured on-the-move and at-a-distance.

    PubMed

    Proença, Hugo; Filipe, Sílvio; Santos, Ricardo; Oliveira, João; Alexandre, Luís A

    2010-08-01

    The iris is regarded as one of the most useful traits for biometric recognition and the dissemination of nationwide iris-based recognition systems is imminent. However, currently deployed systems rely on heavy imaging constraints to capture near infrared images with enough quality. Also, all of the publicly available iris image databases contain data correspondent to such imaging constraints and therefore are exclusively suitable to evaluate methods thought to operate on these type of environments. The main purpose of this paper is to announce the availability of the UBIRIS.v2 database, a multisession iris images database which singularly contains data captured in the visible wavelength, at-a-distance (between four and eight meters) and on on-the-move. This database is freely available for researchers concerned about visible wavelength iris recognition and will be useful in accessing the feasibility and specifying the constraints of this type of biometric recognition.

  7. Cultural Differences in Learning and Implications for Distance Delivery of Educational Programmes to Developing Nations: A Case Study in Fiji

    ERIC Educational Resources Information Center

    Shanahan, Morris W.

    2008-01-01

    Shanahan (2006) found that to be effective the delivery of distance learning programmes to developing nations had to overcome certain constraints, such as cultural constrictions (i.e., issues of language), tradition-based limitations (i.e., paternalistic and hierarchical structures), an inherited past (colonialism), and poor infrastructure…

  8. Open Learning in India: Evolution, Diversification and Reaching Out

    ERIC Educational Resources Information Center

    Sharma, Ramesh C.

    2005-01-01

    Distance education has a history of over four decades in India. There has been a vast growth in the number of learners who need education and thus also the corresponding channels of providing education. Due to the constraints of the traditional educational sector, open and distance learning has been found to be a workable alternative strategy in…

  9. Communications Technologies in Open and Distance Learning in Asia: The Experience of the Asian Development Bank.

    ERIC Educational Resources Information Center

    Sharma, Motilal

    In view of financial constraints, large numbers of students to be educated, and rapid changes in information and communication and information technology, open learning (OL) and distance education (DE) systems are being established at an unprecedented rate in almost all developing countries of the Asian and Pacific region. Modern communications,…

  10. Interspecific geographic range size-body size relationship and the diversification dynamics of Neotropical furnariid birds.

    PubMed

    Inostroza-Michael, Oscar; Hernández, Cristián E; Rodríguez-Serrano, Enrique; Avaria-Llautureo, Jorge; Rivadeneira, Marcelo M

    2018-05-01

    Among the earliest macroecological patterns documented, is the range and body size relationship, characterized by a minimum geographic range size imposed by the species' body size. This boundary for the geographic range size increases linearly with body size and has been proposed to have implications in lineages evolution and conservation. Nevertheless, the macroevolutionary processes involved in the origin of this boundary and its consequences on lineage diversification have been poorly explored. We evaluate the macroevolutionary consequences of the difference (hereafter the distance) between the observed and the minimum range sizes required by the species' body size, to untangle its role on the diversification of a Neotropical species-rich bird clade using trait-dependent diversification models. We show that speciation rate is a positive hump-shaped function of the distance to the lower boundary. The species with highest and lowest distances to minimum range size had lower speciation rates, while species close to medium distances values had the highest speciation rates. Further, our results suggest that the distance to the minimum range size is a macroevolutionary constraint that affects the diversification process responsible for the origin of this macroecological pattern in a more complex way than previously envisioned. © 2018 The Author(s). Evolution © 2018 The Society for the Study of Evolution.

  11. Changes in practice task constraints shape decision-making behaviours of team games players.

    PubMed

    Correia, Vanda; Araújo, Duarte; Duarte, Ricardo; Travassos, Bruno; Passos, Pedro; Davids, Keith

    2012-05-01

    This study examined the effects of manipulating relative positioning between defenders (initial distance apart) on emergent decision-making and actions in a 1 vs. 2 rugby union performance sub-phase. Twelve experienced youth players performed 80 trials of a 1 (attacker) vs. 2 (defenders) practice task in which the starting distance between defenders was systematically decreased. Movement displacement trajectories of participants were video recorded to obtain 2D positional data. The independent variable was the starting distance between defenders and dependent variables were: (i) performance outcome (try or tackle), (ii) mean speed of all players during performance, and (iii), time between the first crossover and the end of the trial. Repeated measures ANOVA was used to compare the effects of different starting distances on performance. Shorter starting distances between defenders were associated with a higher frequency of effective tackle outcomes, lower mean speeds of all participants, and a greater time period between the first crossover and the end of the trial. Decision-making behaviours emerged as a function of changes in participants' spatial location during performance. This observation supports the importance of manipulating key spatial-temporal variables in designing representative practice task constraints that induce functional player-environment interactions in team sports training. Copyright © 2011 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  12. Mission Analysis and Orbit Control of Interferometric Wheel Formation Flying

    NASA Astrophysics Data System (ADS)

    Fourcade, J.

    Flying satellite in formation requires maintaining the specific relative geometry of the spacecraft with high precision. This requirement raises new problem of orbit control. This paper presents the results of the mission analysis of a low Earth observation system, the interferometric wheel, patented by CNES. This wheel is made up of three receiving spacecraft, which follow an emitting Earth observation radar satellite. The first part of this paper presents trades off which were performed to choose orbital elements of the formation flying which fulfils all constraints. The second part presents orbit positioning strategies including reconfiguration of the wheel to change its size. The last part describes the station keeping of the formation. Two kinds of constraints are imposed by the interferometric system : a constraint on the distance between the wheel and the radar satellite, and constraints on the distance between the wheel satellites. The first constraint is fulfilled with a classical chemical station keeping strategy. The second one is fulfilled using pure passive actuators. Due to the high stability of the relative eccentricity of the formation, only the relative semi major axis had to be controlled. Differential drag due to differential attitude motion was used to control relative altitude. An autonomous orbit controller was developed and tested. The final accuracy is a relative station keeping better than few meters for a wheel size of one kilometer.

  13. Analysis of the restricting factors of laser countermeasure active detection technology

    NASA Astrophysics Data System (ADS)

    Zhang, Yufa; Sun, Xiaoquan

    2016-07-01

    The detection effect of laser active detection system is affected by various kinds of factors. In view of the application requirement of laser active detection, the influence factors for laser active detection are analyzed. The mathematical model of cat eye target detection distance has been built, influence of the parameters of laser detection system and the environment on detection range and the detection efficiency are analyzed. Various parameters constraint detection performance is simulated. The results show that the discovery distance of laser active detection is affected by the laser divergence angle, the incident angle and the visibility of the atmosphere. For a given detection range, the laser divergence angle and the detection efficiency are mutually restricted. Therefore, in view of specific application environment, it is necessary to select appropriate laser detection parameters to achieve optimal detection effect.

  14. Self-consistent treatment of electrostatics in molecular DNA braiding through external forces.

    PubMed

    Lee, Dominic J

    2014-06-01

    In this paper we consider a physical system in which two DNA molecules braid about each other. The distance between the two molecular ends, on either side of the braid, is held at a distance much larger than supercoiling radius of the braid. The system is subjected to an external pulling force, and a moment that induces the braiding. In a model, developed for understanding such a system, we assume that each molecule can be divided into a braided and unbraided section. We also suppose that the DNA is nicked so that there is no constraint of the individual linking numbers of the molecules. Included in the model are steric and electrostatic interactions, thermal fluctuations of the braided and unbraided sections of the molecule, as well as the constraint on the braid linking (catenation) number. We compare two approximations used in estimating the free energy of the braided section. One is where the amplitude of undulations of one molecule with respect to the other is determined only by steric interactions. The other is a self-consistent determination of the mean-squared amplitude of these undulations. In this second approximation electrostatics should play an important role in determining this quantity, as suggested by physical arguments. We see that if the electrostatic interaction is sufficiently large there are indeed notable differences between the two approximations. We go on to test the self-consistent approximation-included in the full model-against experimental data for such a system, and we find good agreement. However, there seems to be a slight left-right-handed braid asymmetry in some of the experimental results. We discuss what might be the origin of this small asymmetry.

  15. Elucidating quantitative stability/flexibility relationships within thioredoxin and its fragments using a distance constraint model.

    PubMed

    Jacobs, Donald J; Livesay, Dennis R; Hules, Jeremy; Tasayco, Maria Luisa

    2006-05-05

    Numerous quantitative stability/flexibility relationships, within Escherichia coli thioredoxin (Trx) and its fragments are determined using a minimal distance constraint model (DCM). A one-dimensional free energy landscape as a function of global flexibility reveals Trx to fold in a low-barrier two-state process, with a voluminous transition state. Near the folding transition temperature, the native free energy basin is markedly skewed to allow partial unfolded forms. Under native conditions the skewed shape is lost, and the protein forms a compact structure with some flexibility. Predictions on ten Trx fragments are generally consistent with experimental observations that they are disordered, and that complementary fragments reconstitute. A hierarchical unfolding pathway is uncovered using an exhaustive computational procedure of breaking interfacial cross-linking hydrogen bonds that span over a series of fragment dissociations. The unfolding pathway leads to a stable core structure (residues 22-90), predicted to act as a kinetic trap. Direct connection between degree of rigidity within molecular structure and non-additivity of free energy is demonstrated using a thermodynamic cycle involving fragments and their hierarchical unfolding pathway. Additionally, the model provides insight about molecular cooperativity within Trx in its native state, and about intermediate states populating the folding/unfolding pathways. Native state cooperativity correlation plots highlight several flexibly correlated regions, giving insight into the catalytic mechanism that facilitates access to the active site disulfide bond. Residual native cooperativity correlations are present in the core substructure, suggesting that Trx can function when it is partly unfolded. This natively disordered kinetic trap, interpreted as a molten globule, has a wide temperature range of metastability, and it is identified as the "slow intermediate state" observed in kinetic experiments. These computational results are found to be in overall agreement with a large array of experimental data.

  16. Dynamics of tactical behaviour in association football when manipulating players' space of interaction.

    PubMed

    Ric, Angel; Torrents, Carlota; Gonçalves, Bruno; Torres-Ronda, Lorena; Sampaio, Jaime; Hristovski, Robert

    2017-01-01

    The analysis of positional data in association football allows the spatial distribution of players during matches to be described in order to improve the understanding of tactical-related constraints on the behavioural dynamics of players. The aim of this study was to identify how players' spatial restrictions affected the exploratory tactical behaviour and constrained the perceptual-motor workspace of players in possession of the ball, as well as inter-player passing interactions. Nineteen professional outfield male players were divided into two teams of 10 and 9 players, respectively. The game was played under three spatial constraints: a) players were not allowed to move out of their allocated zones, except for the player in possession of the ball; b) players were allowed to move to an adjacent zone, and; c) non-specific spatial constraints. Positional data was captured using a 5 Hz interpolated GPS tracking system and used to define the configuration states of players for each second in time. The configuration state comprised 37 categories derived from tactical actions, distance from the nearest opponent, distance from the target and movement speed. Notational analysis of players in possession of the ball allowed the mean time of ball possession and the probabilities of passing the ball between players to be calculated. The results revealed that the players' long-term exploratory behaviour decreased and their short-term exploration increased when restricting their space of interaction. Relaxing players' positional constraints seemed to increase the speed of ball flow dynamics. Allowing players to move to an adjacent sub-area increased the probabilities of interaction with the full-back during play build-up. The instability of the coordinative state defined by being free from opponents when players had the ball possession was an invariant feature under all three task constraints. By allowing players to move to adjacent sub-areas, the coordinative state became highly unstable when the distance from the target decreased. Ball location relative to the scoring zone and interpersonal distance constitute key environmental information that constrains the players' coordinative behaviour. Based on our results, dynamic overlap is presented as a good option to capture tactical performance. Moreover, the selected collective (i.e. relational) variables would allow coaches to identify the effects of training drills on teams and players' behaviour. More research is needed considering these type variables to understand how the manipulation of constraints induce a more stable or flexible dynamical structure of tactical behaviour.

  17. Dynamics of tactical behaviour in association football when manipulating players' space of interaction

    PubMed Central

    Torrents, Carlota; Gonçalves, Bruno; Torres-Ronda, Lorena; Sampaio, Jaime; Hristovski, Robert

    2017-01-01

    The analysis of positional data in association football allows the spatial distribution of players during matches to be described in order to improve the understanding of tactical-related constraints on the behavioural dynamics of players. The aim of this study was to identify how players’ spatial restrictions affected the exploratory tactical behaviour and constrained the perceptual-motor workspace of players in possession of the ball, as well as inter-player passing interactions. Nineteen professional outfield male players were divided into two teams of 10 and 9 players, respectively. The game was played under three spatial constraints: a) players were not allowed to move out of their allocated zones, except for the player in possession of the ball; b) players were allowed to move to an adjacent zone, and; c) non-specific spatial constraints. Positional data was captured using a 5 Hz interpolated GPS tracking system and used to define the configuration states of players for each second in time. The configuration state comprised 37 categories derived from tactical actions, distance from the nearest opponent, distance from the target and movement speed. Notational analysis of players in possession of the ball allowed the mean time of ball possession and the probabilities of passing the ball between players to be calculated. The results revealed that the players’ long-term exploratory behaviour decreased and their short-term exploration increased when restricting their space of interaction. Relaxing players’ positional constraints seemed to increase the speed of ball flow dynamics. Allowing players to move to an adjacent sub-area increased the probabilities of interaction with the full-back during play build-up. The instability of the coordinative state defined by being free from opponents when players had the ball possession was an invariant feature under all three task constraints. By allowing players to move to adjacent sub-areas, the coordinative state became highly unstable when the distance from the target decreased. Ball location relative to the scoring zone and interpersonal distance constitute key environmental information that constrains the players’ coordinative behaviour. Based on our results, dynamic overlap is presented as a good option to capture tactical performance. Moreover, the selected collective (i.e. relational) variables would allow coaches to identify the effects of training drills on teams and players’ behaviour. More research is needed considering these type variables to understand how the manipulation of constraints induce a more stable or flexible dynamical structure of tactical behaviour. PMID:28708868

  18. Reconstruction of interaction rate in holographic dark energy

    NASA Astrophysics Data System (ADS)

    Mukherjee, Ankan

    2016-11-01

    The present work is based on the holographic dark energy model with Hubble horizon as the infrared cut-off. The interaction rate between dark energy and dark matter has been reconstructed for three different parameterizations of the deceleration parameter. Observational constraints on the model parameters have been obtained by maximum likelihood analysis using the observational Hubble parameter data (OHD), type Ia supernovab data (SNe), baryon acoustic oscillation data (BAO) and the distance prior of cosmic microwave background (CMB) namely the CMB shift parameter data (CMBShift). The interaction rate obtained in the present work remains always positive and increases with expansion. It is very similar to the result obtained by Sen and Pavon [1] where the interaction rate has been reconstructed for a parametrization of the dark energy equation of state. Tighter constraints on the interaction rate have been obtained in the present work as it is based on larger data sets. The nature of the dark energy equation of state parameter has also been studied for the present models. Though the reconstruction is done from different parametrizations, the overall nature of the interaction rate is very similar in all the cases. Different information criteria and the Bayesian evidence, which have been invoked in the context of model selection, show that the these models are at close proximity of each other.

  19. Information-Driven Blind Doppler Shift Estimation and Compensation Methods for Underwater Wireless Sensor Networks

    DTIC Science & Technology

    2015-08-24

    SUPPLEMENTARY NOTES 12. DISTRIBUTION AVAILIBILITY STATEMENT 6. AUTHORS 7. PERFORMING ORGANIZATION NAMES AND ADDRESSES 15. SUBJECT TERMS b. ABSTRACT 2...network keeping constraints such as transmission rate, transmission delay, Signal-to-Interference and Noise Ratio (SINR) under consideration. Table...distances. It is advantageous to accomplish such transmission using sensors in a multi-hop relay form keeping constraints such as transmission rate

  20. Fast Radio Burst/Gamma-Ray Burst Cosmography

    NASA Astrophysics Data System (ADS)

    Gao, He; Li, Zhuo; Zhang, Bing

    2014-06-01

    Recently, both theoretical arguments and observational evidence suggested that a small fraction of fast radio bursts (FRBs) could be associated with gamma-ray bursts (GRBs). If such FRB/GRB association systems are commonly detected in the future, the combination of dispersion measures (DM) derived from FRBs and redshifts derived from GRBs makes these systems a plausible tool to conduct cosmography. We quantify uncertainties in deriving the redshift-dependent DM_{IGM} as a function of z and test how well dark energy models can be constrained with Monte Carlo simulations. We show that with several tens of FRB/GRB systems potentially detected in a decade or so, one may reach reasonable constraints on wCDM models. When combined with Type Ia supernova (SN Ia) data, unprecedented constraints on the dark energy equation of state may be achieved, thanks to the prospects of detecting FRB/GRB systems at relatively high redshifts. The ratio between the mean value \\lt {DM_IGM} (z)\\gt and luminosity distance (D L(z)) is insensitive to dark energy models. This gives the prospect of applying SN Ia data to calibrate \\lt {DM_IGM} (z)\\gt using a relatively small sample of FRB/GRB systems, allowing a reliable constraint on the baryon inhomogeneity distribution as a function of redshift. The methodology developed in this paper can also be applied if the FRB redshifts can be measured by other means. Some caveats of putting this method into practice are also discussed.

  1. CONSTRAINING THE MILKY WAY POTENTIAL WITH A SIX-DIMENSIONAL PHASE-SPACE MAP OF THE GD-1 STELLAR STREAM

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Koposov, Sergey E.; Rix, Hans-Walter; Hogg, David W., E-mail: koposov@ast.cam.ac.u

    2010-03-20

    The narrow GD-1 stream of stars, spanning 60{sup 0} on the sky at a distance of {approx}10 kpc from the Sun and {approx}15 kpc from the Galactic center, is presumed to be debris from a tidally disrupted star cluster that traces out a test-particle orbit in the Milky Way halo. We combine Sloan Digital Sky Survey (SDSS) photometry, USNO-B astrometry, and SDSS and Calar Alto spectroscopy to construct a complete, empirical six-dimensional (6D) phase-space map of the stream. We find that an eccentric orbit in a flattened isothermal potential describes this phase-space map well. Even after marginalizing over the streammore » orbital parameters and the distance from the Sun to the Galactic center, the orbital fit to GD-1 places strong constraints on the circular velocity at the Sun's radius V{sub c} = 224 +- 13 km s{sup -1} and total potential flattening q{sub P}HI = 0.87{sup +0.07}{sub -0.04}. When we drop any informative priors on V{sub c} , the GD-1 constraint becomes V{sub c} = 221 +- 18 km s{sup -1}. Our 6D map of GD-1, therefore, yields the best current constraint on V{sub c} and the only strong constraint on q{sub P}HI at Galactocentric radii near R {approx} 15 kpc. Much, if not all, of the total potential flattening may be attributed to the mass in the stellar disk, so the GD-1 constraints on the flattening of the halo itself are weak: q{sub P}HI{sub ,halo} > 0.89 at 90% confidence. The greatest uncertainty in the 6D map and the orbital analysis stems from the photometric distances, which will be obviated by GAIA.« less

  2. A neurocomputational system for relational reasoning.

    PubMed

    Knowlton, Barbara J; Morrison, Robert G; Hummel, John E; Holyoak, Keith J

    2012-07-01

    The representation and manipulation of structured relations is central to human reasoning. Recent work in computational modeling and neuroscience has set the stage for developing more detailed neurocomputational models of these abilities. Several key neural findings appear to dovetail with computational constraints derived from a model of analogical processing, 'Learning and Inference with Schemas and Analogies' (LISA). These include evidence that (i) coherent oscillatory activity in the gamma and theta bands enables long-distance communication between the prefrontal cortex and posterior brain regions where information is stored; (ii) neurons in prefrontal cortex can rapidly learn to represent abstract concepts; (iii) a rostral-caudal abstraction gradient exists in the PFC; and (iv) the inferior frontal gyrus exerts inhibitory control over task-irrelevant information. Copyright © 2012. Published by Elsevier Ltd.

  3. The Earth Is Flat when Personally Significant Experiences with the Sphericity of the Earth Are Absent

    ERIC Educational Resources Information Center

    Carbon, Claus-Christian

    2010-01-01

    Participants with personal and without personal experiences with the Earth as a sphere estimated large-scale distances between six cities located on different continents. Cognitive distances were submitted to a specific multidimensional scaling algorithm in the 3D Euclidean space with the constraint that all cities had to lie on the same sphere. A…

  4. Cost Effectiveness of Open and Distance Learning in Nigeria: Responses from Focus Group Discussions

    ERIC Educational Resources Information Center

    Ojo, David Olugbenga; Rotimi, Ogidan; Kayode, Olakulehin Felix

    2006-01-01

    This study reports the out come of a primary qualitative investigation of open and distance learning system of education as a panacea to the problem of socially induced constraints on the acquisition of education, that may lead to the inability to attend higher institutions of learning, acquire certificates, become a qualified skilled worker by…

  5. Advanced Models of Accretion Disk Atmospheres and Spectra for Close Binary Stars

    NASA Technical Reports Server (NTRS)

    Wade, Richard A.

    1997-01-01

    This work led to the development of code for fitting models to data, and to an understanding of the nature of the models which enabled a more rapid search of 'parameter space' for optimal fits to spectral data sets. The code was used to find optimal fits to IUE spectra of quiescent dwarf novae that have been reported to show evidence for the white dwarf. The models consisted of a white dwarf component and an accretion disk with boundary conditions appropriate for the choice of the white dwarf. The preliminary work has strengthened the initial impression that accretion disk spectra can mimic the appearance of white dwarf spectra in the short-wavelength ultraviolet, so that additional constraints (such as distance) are needed to distinguish to two cases.

  6. Increased distance of shooting on basketball jump shot.

    PubMed

    Okazaki, Victor Hugo Alves; Rodacki, André Luiz Félix

    2012-01-01

    The present study analyzed the effect of increased distance on basketball jump shot outcome and performance. Ten male expert basketball players were filmed and a number of kinematic variables analyzed during jump shot that were performed from three conditions to represent close, intermediate and far distances (2.8, 4.6, and 6.4m, respectively). Shot accuracy decreased from 59% (close) to 37% (far), in function of the task constraints (p < 0.05). Ball release height decreased (p < 0.05) from 2.46 m (close) to 2.38m (intermediate) and to 2.33m (long). Release angle also decreased (p < 0.05) when shot was performed from close (78.92°) in comparison to intermediate distances (65.60°). While, ball release velocity increased (p < 0.05) from 4.39 m/s (close) to 5.75 m·s(-1) (intermediate) to 6.89 m·s(-1) (far). These changes in ball release height, angle and velocity, related to movement performance adaptations were suggested as the main factors that influence jump shot accuracy when distance is augmented. Key pointsThe increased distance leads to greater spatial con-straint over shot movement that demands an adapta-tion of the movement for the regulation of the accu-racy and the impulse generation to release the ball.The reduction in balls release height and release angle, in addition to the increase in balls release ve-locity, were suggested as the main factors that de-creased shot accuracy with the distance increased.Players should look for release angles of shooting that provide an optimal balls release velocity to im-prove accuracy.

  7. A Constrained Scheme for High Precision Downward Continuation of Potential Field Data

    NASA Astrophysics Data System (ADS)

    Wang, Jun; Meng, Xiaohong; Zhou, Zhiwen

    2018-04-01

    To further improve the accuracy of the downward continuation of potential field data, we present a novel constrained scheme in this paper combining the ideas of the truncated Taylor series expansion, the principal component analysis, the iterative continuation and the prior constraint. In the scheme, the initial downward continued field on the target plane is obtained from the original measured field using the truncated Taylor series expansion method. If the original field was with particularly low signal-to-noise ratio, the principal component analysis is utilized to suppress the noise influence. Then, the downward continued field is upward continued to the plane of the prior information. If the prior information was on the target plane, it should be upward continued over a short distance to get the updated prior information. Next, the difference between the calculated field and the updated prior information is calculated. The cosine attenuation function is adopted to get the scope of constraint and the corresponding modification item. Afterward, a correction is performed on the downward continued field on the target plane by adding the modification item. The correction process is iteratively repeated until the difference meets the convergence condition. The accuracy of the proposed constrained scheme is tested on synthetic data with and without noise. Numerous model tests demonstrate that downward continuation using the constrained strategy can yield more precise results compared to other downward continuation methods without constraints and is relatively insensitive to noise even for downward continuation over a large distance. Finally, the proposed scheme is applied to real magnetic data collected within the Dapai polymetallic deposit from the Fujian province in South China. This practical application also indicates the superiority of the presented scheme.

  8. Constraining parameters of white-dwarf binaries using gravitational-wave and electromagnetic observations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shah, Sweta; Nelemans, Gijs, E-mail: s.shah@astro.ru.nl

    The space-based gravitational wave (GW) detector, evolved Laser Interferometer Space Antenna (eLISA) is expected to observe millions of compact Galactic binaries that populate our Milky Way. GW measurements obtained from the eLISA detector are in many cases complimentary to possible electromagnetic (EM) data. In our previous papers, we have shown that the EM data can significantly enhance our knowledge of the astrophysically relevant GW parameters of Galactic binaries, such as the amplitude and inclination. This is possible due to the presence of some strong correlations between GW parameters that are measurable by both EM and GW observations, for example, themore » inclination and sky position. In this paper, we quantify the constraints in the physical parameters of the white-dwarf binaries, i.e., the individual masses, chirp mass, and the distance to the source that can be obtained by combining the full set of EM measurements such as the inclination, radial velocities, distances, and/or individual masses with the GW measurements. We find the following 2σ fractional uncertainties in the parameters of interest. The EM observations of distance constrain the chirp mass to ∼15%-25%, whereas EM data of a single-lined spectroscopic binary constrain the secondary mass and the distance with factors of two to ∼40%. The single-line spectroscopic data complemented with distance constrains the secondary mass to ∼25%-30%. Finally, EM data on double-lined spectroscopic binary constrain the distance to ∼30%. All of these constraints depend on the inclination and the signal strength of the binary systems. We also find that the EM information on distance and/or the radial velocity are the most useful in improving the estimate of the secondary mass, inclination, and/or distance.« less

  9. The QKD network: model and routing scheme

    NASA Astrophysics Data System (ADS)

    Yang, Chao; Zhang, Hongqi; Su, Jinhai

    2017-11-01

    Quantum key distribution (QKD) technology can establish unconditional secure keys between two communicating parties. Although this technology has some inherent constraints, such as the distance and point-to-point mode limits, building a QKD network with multiple point-to-point QKD devices can overcome these constraints. Considering the development level of current technology, the trust relaying QKD network is the first choice to build a practical QKD network. However, the previous research didn't address a routing method on the trust relaying QKD network in detail. This paper focuses on the routing issues, builds a model of the trust relaying QKD network for easily analysing and understanding this network, and proposes a dynamical routing scheme for this network. From the viewpoint of designing a dynamical routing scheme in classical network, the proposed scheme consists of three components: a Hello protocol helping share the network topology information, a routing algorithm to select a set of suitable paths and establish the routing table and a link state update mechanism helping keep the routing table newly. Experiments and evaluation demonstrates the validity and effectiveness of the proposed routing scheme.

  10. A few words about resonances in the electroweak effective Lagrangian

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosell, Ignasi; Pich, Antonio; Santos, Joaquín

    Contrary to a widely spread believe, we have demonstrated that strongly coupled electroweak models including both a light Higgs-like boson and massive spin-1 resonances are not in conflict with experimental constraints on the oblique S and T parameters. We use an effective Lagrangian implementing the chiral symmetry breaking SU (2){sub L} ⊗ SU (2){sub R} → SU (2){sub L+R} that contains the Standard Model gauge bosons coupled to the electroweak Goldstones, one Higgs-like scalar state h with mass m{sub h} = 126 GeV and the lightest vector and axial-vector resonance multiplets V and A. We have considered the one-loop calculationmore » of S and T in order to study the viability of these strongly-coupled scenarios, being short-distance constraints and dispersive relations the main ingredients of the calculation. Once we have constrained the resonance parameters, we do a first approach to the determination of the low energy constants of the electroweak effective theory at low energies (without resonances). We show this determination in the case of the purely Higgsless bosonic Lagrangian.« less

  11. Asymptotic analysis of noisy fitness maximization, applied to metabolism & growth

    NASA Astrophysics Data System (ADS)

    De Martino, Daniele; Masoero, Davide

    2016-12-01

    We consider a population dynamics model coupling cell growth to a diffusion in the space of metabolic phenotypes as it can be obtained from realistic constraints-based modeling. In the asymptotic regime of slow diffusion, that coincides with the relevant experimental range, the resulting non-linear Fokker-Planck equation is solved for the steady state in the WKB approximation that maps it into the ground state of a quantum particle in an Airy potential plus a centrifugal term. We retrieve scaling laws for growth rate fluctuations and time response with respect to the distance from the maximum growth rate suggesting that suboptimal populations can have a faster response to perturbations.

  12. Empirical Constraints on Proton and Electron Heating in the Fast Solar Wind

    NASA Technical Reports Server (NTRS)

    Cranmer, Steven R.; Matthaeus, William H.; Breech, Benjamin A.; Kasper, Justin C.

    2009-01-01

    This paper presents analyses of measured proton and electron temperatures in the high-speed solar wind that are used to calculate the separate rates of heat deposition for protons and electrons. It was found that the protons receive about 60% of the total plasma heating in the inner heliosphere, and that this fraction increases to approximately 80% by the orbit of Jupiter. The empirically derived partitioning of heat between protons and electrons is in rough agreement with theoretical predictions from a model of linear Vlasov wave damping. For a modeled power spectrum consisting only of Alfvenic fluctuations, the best agreement was found for a distribution of wavenumber vectors that evolves toward isotropy as distance increases.

  13. Phylogeny and species traits predict bird detectability

    USGS Publications Warehouse

    Solymos, Peter; Matsuoka, Steven M.; Stralberg, Diana; Barker, Nicole K. S.; Bayne, Erin M.

    2018-01-01

    Avian acoustic communication has resulted from evolutionary pressures and ecological constraints. We therefore expect that auditory detectability in birds might be predictable by species traits and phylogenetic relatedness. We evaluated the relationship between phylogeny, species traits, and field‐based estimates of the two processes that determine species detectability (singing rate and detection distance) for 141 bird species breeding in boreal North America. We used phylogenetic mixed models and cross‐validation to compare the relative merits of using trait data only, phylogeny only, or the combination of both to predict detectability. We found a strong phylogenetic signal in both singing rates and detection distances; however the strength of phylogenetic effects was less than expected under Brownian motion evolution. The evolution of behavioural traits that determine singing rates was found to be more labile, leaving more room for species to evolve independently, whereas detection distance was mostly determined by anatomy (i.e. body size) and thus the laws of physics. Our findings can help in disentangling how complex ecological and evolutionary mechanisms have shaped different aspects of detectability in boreal birds. Such information can greatly inform single‐ and multi‐species models but more work is required to better understand how to best correct possible biases in phylogenetic diversity and other community metrics.

  14. Detecting chameleons through Casimir force measurements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brax, Philippe; Bruck, Carsten van de; Davis, Anne-Christine

    2007-12-15

    The best laboratory constraints on strongly coupled chameleon fields come not from tests of gravity per se but from precision measurements of the Casimir force. The chameleonic force between two nearby bodies is more akin to a Casimir-like force than a gravitational one: The chameleon force behaves as an inverse power of the distance of separation between the surfaces of two bodies, just as the Casimir force does. Additionally, experimental tests of gravity often employ a thin metallic sheet to shield electrostatic forces; however, this sheet masks any detectable signal due to the presence of a strongly coupled chameleon field.more » As a result of this shielding, experiments that are designed to specifically test the behavior of gravity are often unable to place any constraint on chameleon fields with a strong coupling to matter. Casimir force measurements do not employ a physical electrostatic shield and as such are able to put tighter constraints on the properties of chameleons fields with a strong matter coupling than tests of gravity. Motivated by this, we perform a full investigation on the possibility of testing chameleon models with both present and future Casimir experiments. We find that present-day measurements are not able to detect the chameleon. However, future experiments have a strong possibility of detecting or rule out a whole class of chameleon models.« less

  15. Moon illusion and spiral aftereffect: illusions due to the loom-zoom system?

    PubMed

    Hershenson, M

    1982-12-01

    The moon illusion and the spiral aftereffect are illusions in which apparent size and apparent distance vary inversely. Because this relationship is exactly opposite to that predicted by the static size--distance invariance hypothesis, the illusions have been called "paradoxical." The illusions may be understood as products of a loom-zoom system, a hypothetical visual subsystem that, in its normal operation, acts according to its structural constraint, the constancy axiom, to produce perceptions that satisfy the constraints of stimulation, the kinetic size--distance invariance hypothesis. When stimulated by its characteristic stimulus of symmetrical expansion or contraction, the loom-zoom system produces the perception of a rigid object moving in depth. If this system is stimulated by a rotating spiral, a negative motion-aftereffect is produced when rotation ceases. If fixation is then shifted to a fixed-sized disc, the aftereffect process alters perceived distance and the loom-zoom system alters perceived size such that the disc appears to expand and approach or to contract and recede, depending on the direction of rotation of the spiral. If the loom-zoom system is stimulated by a moon-terrain configuration, the equidistance tendency produces a foreshortened perceived distance for the moon as an inverse function of elevation and acts in conjunction with the loom-zoom system to produce the increased perceived size of the moon.

  16. Coupling 3D groundwater modeling with CFC-based age dating to classify local groundwater circulation in an unconfined crystalline aquifer

    NASA Astrophysics Data System (ADS)

    Kolbe, Tamara; Marçais, Jean; Thomas, Zahra; Abbott, Benjamin W.; de Dreuzy, Jean-Raynald; Rousseau-Gueutin, Pauline; Aquilina, Luc; Labasque, Thierry; Pinay, Gilles

    2016-12-01

    Nitrogen pollution of freshwater and estuarine environments is one of the most urgent environmental crises. Shallow aquifers with predominantly local flow circulation are particularly vulnerable to agricultural contaminants. Water transit time and flow path are key controls on catchment nitrogen retention and removal capacity, but the relative importance of hydrogeological and topographical factors in determining these parameters is still uncertain. We used groundwater dating and numerical modeling techniques to assess transit time and flow path in an unconfined aquifer in Brittany, France. The 35.5 km2 study catchment has a crystalline basement underneath a ∼60 m thick weathered and fractured layer, and is separated into a distinct upland and lowland area by an 80 m-high butte. We used groundwater discharge and groundwater ages derived from chlorofluorocarbon (CFC) concentration to calibrate a free-surface flow model simulating groundwater flow circulation. We found that groundwater flow was highly local (mean travel distance = 350 m), substantially smaller than the typical distance between neighboring streams (∼1 km), while CFC-based ages were quite old (mean = 40 years). Sensitivity analysis revealed that groundwater travel distances were not sensitive to geological parameters (i.e. arrangement of geological layers and permeability profile) within the constraints of the CFC age data. However, circulation was sensitive to topography in the lowland area where the water table was near the land surface, and to recharge rate in the upland area where water input modulated the free surface of the aquifer. We quantified these differences with a local groundwater ratio (rGW-LOCAL), defined as the mean groundwater travel distance divided by the mean of the reference surface distances (the distance water would have to travel across the surface of the digital elevation model). Lowland, rGW-LOCAL was near 1, indicating primarily topographical controls. Upland, rGW-LOCAL was 1.6, meaning the groundwater recharge area is almost twice as large as the topographically-defined catchment for any given point. The ratio rGW-LOCAL is sensitive to recharge conditions as well as topography and it could be used to compare controls on groundwater circulation within or between catchments.

  17. New Observational Constraints to Milky Way Chemodynamical Models

    NASA Astrophysics Data System (ADS)

    Chiappini, Cristina; Minchev, Ivan; Anders, Friedrich; Brauer, Dorothee; Boeche, Corrado; Martig, Marie

    Galactic Archaeology, i.e. the use of chemo-dynamical information for stellar samples covering large portions of the Milky Way to infer the dominant processes involved in its formation and evolution, is now a powerful method thanks to the large recently completed and ongoing spectroscopic surveys. It is now important to ask the right questions when analyzing and interpreting the information contained in these rich datasets. To this aim, we have developed a chemodynamical model for the Milky Way that provides quantitative predictions to be compared with the chemo-kinematical properties extracted from the stellar spectra. Three key parameters are needed to make the comparison between data and model predictions useful in order to advance in the field, namely: precise proper-motions, distances and ages. The uncertainties involved in the estimate of ages and distances for field stars are currently the main obstacles in the Galactic Archaeology method. Two important developments might change this situation in the near future: asteroseismology and the now launched Gaia. When combined with the large datasets from surveys like RAVE, SEGUE, LAMOST, Gaia-ESO, APOGEE, HERMES and the future 4MOST we will have the basic ingredients for the reconstruction of the MW history in hands. In the light of these observational advances, the development of detailed chemo-dynamical models tailored to the Milky Way is urgently needed in the field. Here we show the steps we have taken, both in terms of data analysis and modelling. The examples shown here illustrate how powerful can the Galactic Archaeology method become once ages and distances are known with better precision than what is currently feasible.

  18. Firefighter Training in Sweden: From Face-to-Face Learning in Training Grounds to Distance Learning--A Challenge for Exercise Instructors?

    ERIC Educational Resources Information Center

    Holmgren, Robert

    2016-01-01

    When distance learning supported by digital technologies was introduced in firefighter training in Sweden some years ago, training exercise instructors accustomed to face-to-face teaching in the field had to adapt their professional roles to an electronic landscape with a number of new opportunities and constraints. Based on activity theory and…

  19. The importance of including local correlation times in the calculation of inter-proton distances from NMR measurements: ignoring local correlation times leads to significant errors in the conformational analysis of the Glc alpha1-2Glc alpha linkage by NMR spectroscopy.

    PubMed

    Mackeen, Mukram; Almond, Andrew; Cumpstey, Ian; Enis, Seth C; Kupce, Eriks; Butters, Terry D; Fairbanks, Antony J; Dwek, Raymond A; Wormald, Mark R

    2006-06-07

    The experimental determination of oligosaccharide conformations has traditionally used cross-linkage 1H-1H NOE/ROEs. As relatively few NOEs are observed, to provide sufficient conformational constraints this method relies on: accurate quantification of NOE intensities (positive constraints); analysis of absent NOEs (negative constraints); and hence calculation of inter-proton distances using the two-spin approximation. We have compared the results obtained by using 1H 2D NOESY, ROESY and T-ROESY experiments at 500 and 700 MHz to determine the conformation of the terminal Glc alpha1-2Glc alpha linkage in a dodecasaccharide and a related tetrasaccharide. For the tetrasaccharide, the NOESY and ROESY spectra produced the same qualitative pattern of linkage cross-peaks but the quantitative pattern, the relative peak intensities, was different. For the dodecasaccharide, the NOESY and ROESY spectra at 500 MHz produced a different qualitative pattern of linkage cross-peaks, with fewer peaks in the NOESY spectrum. At 700 MHz, the NOESY and ROESY spectra of the dodecasaccharide produced the same qualitative pattern of peaks, but again the relative peak intensities were different. These differences are due to very significant differences in the local correlation times for different proton pairs across this glycosidic linkage. The local correlation time for each proton pair was measured using the ratio of the NOESY and T-ROESY cross-relaxation rates, leaving the NOESY and ROESY as independent data sets for calculating the inter-proton distances. The inter-proton distances calculated including the effects of differences in local correlation times give much more consistent results.

  20. Optimal group size in a highly social mammal

    PubMed Central

    Markham, A. Catherine; Gesquiere, Laurence R.; Alberts, Susan C.; Altmann, Jeanne

    2015-01-01

    Group size is an important trait of social animals, affecting how individuals allocate time and use space, and influencing both an individual’s fitness and the collective, cooperative behaviors of the group as a whole. Here we tested predictions motivated by the ecological constraints model of group size, examining the effects of group size on ranging patterns and adult female glucocorticoid (stress hormone) concentrations in five social groups of wild baboons (Papio cynocephalus) over an 11-y period. Strikingly, we found evidence that intermediate-sized groups have energetically optimal space-use strategies; both large and small groups experience ranging disadvantages, in contrast to the commonly reported positive linear relationship between group size and home range area and daily travel distance, which depict a disadvantage only in large groups. Specifically, we observed a U-shaped relationship between group size and home range area, average daily distance traveled, evenness of space use within the home range, and glucocorticoid concentrations. We propose that a likely explanation for these U-shaped patterns is that large, socially dominant groups are constrained by within-group competition, whereas small, socially subordinate groups are constrained by between-group competition and predation pressures. Overall, our results provide testable hypotheses for evaluating group-size constraints in other group-living species, in which the costs of intra- and intergroup competition vary as a function of group size. PMID:26504236

  1. Vivaldi: visualization and validation of biomacromolecular NMR structures from the PDB.

    PubMed

    Hendrickx, Pieter M S; Gutmanas, Aleksandras; Kleywegt, Gerard J

    2013-04-01

    We describe Vivaldi (VIsualization and VALidation DIsplay; http://pdbe.org/vivaldi), a web-based service for the analysis, visualization, and validation of NMR structures in the Protein Data Bank (PDB). Vivaldi provides access to model coordinates and several types of experimental NMR data using interactive visualization tools, augmented with structural annotations and model-validation information. The service presents information about the modeled NMR ensemble, validation of experimental chemical shifts, residual dipolar couplings, distance and dihedral angle constraints, as well as validation scores based on empirical knowledge and databases. Vivaldi was designed for both expert NMR spectroscopists and casual non-expert users who wish to obtain a better grasp of the information content and quality of NMR structures in the public archive. Copyright © 2013 Wiley Periodicals, Inc.

  2. Glue detection based on teaching points constraint and tracking model of pixel convolution

    NASA Astrophysics Data System (ADS)

    Geng, Lei; Ma, Xiao; Xiao, Zhitao; Wang, Wen

    2018-01-01

    On-line glue detection based on machine version is significant for rust protection and strengthening in car production. Shadow stripes caused by reflect light and unevenness of inside front cover of car reduce the accuracy of glue detection. In this paper, we propose an effective algorithm to distinguish the edges of the glue and shadow stripes. Teaching points are utilized to calculate slope between the two adjacent points. Then a tracking model based on pixel convolution along motion direction is designed to segment several local rectangular regions using distance. The distance is the height of rectangular region. The pixel convolution along the motion direction is proposed to extract edges of gules in local rectangular region. A dataset with different illumination and complexity shape stripes are used to evaluate proposed method, which include 500 thousand images captured from the camera of glue gun machine. Experimental results demonstrate that the proposed method can detect the edges of glue accurately. The shadow stripes are distinguished and removed effectively. Our method achieves the 99.9% accuracies for the image dataset.

  3. THE PLASMA ENVIRONMENT IN COMETS OVER A WIDE RANGE OF HELIOCENTRIC DISTANCES: APPLICATION TO COMET C/2006 P1 (MCNAUGHT)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shou, Y.; Combi, M.; Gombosi, T.

    2015-08-20

    On 2007 January 12, comet C/2006 P1 (McNaught) passed its perihelion at 0.17 AU. Abundant remote observations offer plenty of information on the neutral composition and neutral velocities within 1 million kilometers of the comet nucleus. In early February, the Ulysses spacecraft made an in situ measurement of the ion composition, plasma velocity, and magnetic field when passing through the distant ion tail and the ambient solar wind. The measurement by Ulysses was made when the comet was at around 0.8 AU. With the constraints provided by remote and in situ observations, we simulated the plasma environment of Comet C/2006more » P1 (McNaught) using a multi-species comet MHD model over a wide range of heliocentric distances from 0.17 to 1.75 AU. The solar wind interaction of the comet at various locations is characterized and typical subsolar standoff distances of the bow shock and contact surface are presented and compared to analytic solutions. We find the variation in the bow shock standoff distances at different heliocentric distances is smaller than the contact surface. In addition, we modified the multi-species model for the case when the comet was at 0.7 AU and achieved comparable water group ion abundances, proton densities, plasma velocities, and plasma temperatures to the Ulysses/SWICS and SWOOPS observations. We discuss the dominating chemical reactions throughout the comet-solar wind interaction region and demonstrate the link between the ion composition near the comet and in the distant tail as measured by Ulysses.« less

  4. OpenACC directive-based GPU acceleration of an implicit reconstructed discontinuous Galerkin method for compressible flows on 3D unstructured grids

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lou, Jialin; Xia, Yidong; Luo, Lixiang

    2016-09-01

    In this study, we use a combination of modeling techniques to describe the relationship between fracture radius that might be accomplished in a hypothetical enhanced geothermal system (EGS) and drilling distance required to create and access those fractures. We use a combination of commonly applied analytical solutions for heat transport in parallel fractures and 3D finite-element method models of more realistic heat extraction geometries. For a conceptual model involving multiple parallel fractures developed perpendicular to an inclined or horizontal borehole, calculations demonstrate that EGS will likely require very large fractures, of greater than 300 m radius, to keep interfracture drillingmore » distances to ~10 km or less. As drilling distances are generally inversely proportional to the square of fracture radius, drilling costs quickly escalate as the fracture radius decreases. It is important to know, however, whether fracture spacing will be dictated by thermal or mechanical considerations, as the relationship between drilling distance and number of fractures is quite different in each case. Information about the likelihood of hydraulically creating very large fractures comes primarily from petroleum recovery industry data describing hydraulic fractures in shale. Those data suggest that fractures with radii on the order of several hundred meters may, indeed, be possible. The results of this study demonstrate that relatively simple calculations can be used to estimate primary design constraints on a system, particularly regarding the relationship between generated fracture radius and the total length of drilling needed in the fracture creation zone. Comparison of the numerical simulations of more realistic geometries than addressed in the analytical solutions suggest that simple proportionalities can readily be derived to relate a particular flow field.« less

  5. Model-independent Constraints on Cosmic Curvature and Opacity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Guo-Jian; Li, Zheng-Xiang; Xia, Jun-Qing

    2017-09-20

    In this paper, we propose to estimate the spatial curvature of the universe and the cosmic opacity in a model-independent way with expansion rate measurements, H ( z ), and type Ia supernova (SNe Ia). On the one hand, using a nonparametric smoothing method Gaussian process, we reconstruct a function H ( z ) from opacity-free expansion rate measurements. Then, we integrate the H ( z ) to obtain distance modulus μ {sub H}, which is dependent on the cosmic curvature. On the other hand, distances of SNe Ia can be determined by their photometric observations and thus are opacity-dependent.more » In our analysis, by confronting distance moduli μ {sub H} with those obtained from SNe Ia, we achieve estimations for both the spatial curvature and the cosmic opacity without any assumptions for the cosmological model. Here, it should be noted that light curve fitting parameters, accounting for the distance estimation of SNe Ia, are determined in a global fit together with the cosmic opacity and spatial curvature to get rid of the dependence of these parameters on cosmology. In addition, we also investigate whether the inclusion of different priors for the present expansion rate ( H {sub 0}: global estimation, 67.74 ± 0.46 km s{sup −1} Mpc{sup −1}, and local measurement, 73.24 ± 1.74 km s{sup −1} Mpc{sup −1}) exert influence on the reconstructed H ( z ) and the following estimations of the spatial curvature and cosmic opacity. Results show that, in general, a spatially flat and transparent universe is preferred by the observations. Moreover, it is suggested that priors for H {sub 0} matter a lot. Finally, we find that there is a strong degeneracy between the curvature and the opacity.« less

  6. Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes

    PubMed Central

    Moreno, Claudia M.; O’Dwyer, Samantha; Woods, Sean

    2017-01-01

    TRPV4 (transient receptor potential vanilloid 4) channels are Ca2+-permeable channels that play a key role in regulating vascular tone. In arterial myocytes, opening of TRPV4 channels creates local increases in Ca2+ influx, detectable optically as “TRPV4 sparklets.” TRPV4 sparklet activity can be enhanced by the action of the vasoconstrictor angiotensin II (AngII). This modulation depends on the activation of subcellular signaling domains that comprise protein kinase C α (PKCα) bound to the anchoring protein AKAP150. Here, we used super-resolution nanoscopy, patch-clamp electrophysiology, Ca2+ imaging, and mathematical modeling approaches to test the hypothesis that AKAP150-dependent modulation of TRPV4 channels is critically dependent on the distance between these two proteins in the sarcolemma of arterial myocytes. Our data show that the distance between AKAP150 and TRPV4 channel clusters varies with sex and arterial bed. Consistent with our hypothesis, we further find that basal and AngII-induced TRPV4 channel activity decays exponentially as the distance between TRPV4 and AKAP150 increases. Our data suggest a maximum radius of action of ∼200 nm for local modulation of TRPV4 channels by AKAP150-associated PKCα. PMID:28507079

  7. Behavioural variability and motor performance: Effect of practice specialization in front crawl swimming.

    PubMed

    Seifert, L; De Jesus, K; Komar, J; Ribeiro, J; Abraldes, J A; Figueiredo, P; Vilas-Boas, J P; Fernandes, R J

    2016-06-01

    The aim was to examine behavioural variability within and between individuals, especially in a swimming task, to explore how swimmers with various specialty (competitive short distance swimming vs. triathlon) adapt to repetitive events of sub-maximal intensity, controlled in speed but of various distances. Five swimmers and five triathletes randomly performed three variants (with steps of 200, 300 and 400m distances) of a front crawl incremental step test until exhaustion. Multi-camera system was used to collect and analyse eight kinematical and swimming efficiency parameters. Analysis of variance showed significant differences between swimmers and triathletes, with significant individual effect. Cluster analysis put these parameters together to investigate whether each individual used the same pattern(s) and one or several patterns to achieve the task goal. Results exhibited ten patterns for the whole population, with only two behavioural patterns shared between swimmers and triathletes. Swimmers tended to use higher hand velocity and index of coordination than triathletes. Mono-stability occurred in swimmers whatever the task constraint showing high stability, while triathletes revealed bi-stability because they switched to another pattern at mid-distance of the task. Finally, our analysis helped to explain and understand effect of specialty and more broadly individual adaptation to task constraint. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. THE FIRST DISTANCE CONSTRAINT ON THE RENEGADE HIGH-VELOCITY CLOUD COMPLEX WD

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peek, J. E. G.; Roman-Duval, Julia; Tumlinson, Jason

    2016-09-10

    We present medium-resolution, near-ultraviolet Very Large Telescope/FLAMES observations of the star USNO-A0600-15865535. We adapt a standard method of stellar typing to our measurement of the shape of the Balmer ϵ absorption line to demonstrate that USNO-A0600-15865535 is a blue horizontal branch star, residing in the lower stellar halo at a distance of 4.4 kpc from the Sun. We measure the H and K lines of singly ionized calcium and find two isolated velocity components, one originating in the disk, and one associated with the high-velocity cloud complex WD. This detection demonstrated that complex WD is closer than ∼4.4 kpc andmore » is the first distance constraint on the +100 km s{sup −1} Galactic complex of clouds. We find that complex WD is not in corotation with the Galactic disk, which has been assumed for decades. We examine a number of scenarios and find that the most likely scenario is that complex WD was ejected from the solar neighborhood and is only a few kiloparsecs from the Sun.« less

  9. Mutual information in the evolution of trajectories in discrete aiming movements.

    PubMed

    Lai, Shih-Chiung; Mayer-Kress, Gottfried; Newell, Karl M

    2008-07-01

    This study investigated the mutual information in the trajectories of discrete aiming movements on a computer controlled graphics tablet where movement time ( 300 - 2050 ms) was manipulated in a given distance (100 mm) and movement distance (15-240 mm) in 2 given movement times (300 ms and 800 ms ). For the distance-fixed conditions, there was higher mutual information in the slower movements in the 0 vs. 80-100% trajectory point comparisons, whereas the mutual information was higher for the faster movements when comparing within the 80 and 100% points of the movement trajectory. For the time-fixed conditions, the spatial constraints led to a decreasing pattern of the mutual information throughout the points of the trajectory, with the highest mutual information found in the 80 vs. 100% comparison. Overall, the pattern of mutual information reveals systematic modulation of the trajectories between the attractive fixed point of the target as a function of movement condition. These mutual information patterns are postulated to be the consequence of the different relative contributions of feedforward and feedback control processes in trajectory formation as a function of task constraints.

  10. Reconstruction of interaction rate in holographic dark energy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mukherjee, Ankan, E-mail: ankan_ju@iiserkol.ac.in

    2016-11-01

    The present work is based on the holographic dark energy model with Hubble horizon as the infrared cut-off. The interaction rate between dark energy and dark matter has been reconstructed for three different parameterizations of the deceleration parameter. Observational constraints on the model parameters have been obtained by maximum likelihood analysis using the observational Hubble parameter data (OHD), type Ia supernovab data (SNe), baryon acoustic oscillation data (BAO) and the distance prior of cosmic microwave background (CMB) namely the CMB shift parameter data (CMBShift). The interaction rate obtained in the present work remains always positive and increases with expansion. Itmore » is very similar to the result obtained by Sen and Pavon [1] where the interaction rate has been reconstructed for a parametrization of the dark energy equation of state. Tighter constraints on the interaction rate have been obtained in the present work as it is based on larger data sets. The nature of the dark energy equation of state parameter has also been studied for the present models. Though the reconstruction is done from different parametrizations, the overall nature of the interaction rate is very similar in all the cases. Different information criteria and the Bayesian evidence, which have been invoked in the context of model selection, show that the these models are at close proximity of each other.« less

  11. State transitions of GRS 1739-278 in the 2014 outburst

    NASA Astrophysics Data System (ADS)

    Wang, Sili; Kawai, Nobuyuki; Shidatsu, Megumi; Tachibana, Yutaro; Yoshii, Taketoshi; Sudo, Masayuki; Kubota, Aya

    2018-05-01

    We report on the X-ray spectral analysis and time evolution of GRS 1739-278 during its 2014 outburst, based on MAXI/GSC and Swift/XRT observations. Over the course of the outburst, a transition from the low/hard state to the high/soft state and then back to the low/hard state was seen. During the high/soft state, the innermost disk temperature mildly decreased, while the innermost radius estimated with the multi-color disk model remained constant at ˜18 (D/8.5 kpc)(cos i/cos 30°)-1/2 km, where D is the source distance and i is the inclination of observation. This small innermost radius of the accretion disk suggests that the central object is more likely to be a Kerr black hole rather than a Schwardzschild black hole. Applying a relativistic disk emission model to the high/soft state spectra, a mass upper limit of 18.3 M⊙ was obtained based on the inclination limit i < 60° for an assumed distance of 8.5 kpc. Using the empirical relation of the transition luminosity to the Eddington limit, the mass is constrained to 4.0-18.3 M⊙ for the same distance. The mass can be further constrained to be no larger than 9.5 M⊙ by adopting the constraints based on the fits to the NuSTAR spectra with relativistically blurred disk reflection models (Miller et al. 2015, ApJ, 799, L6).

  12. Coevolution of dependency distance, hierarchical structure and word order. Comment on "Dependency distance: a new perspective on syntactic patterns in natural languages" by Haitao Liu et al.

    NASA Astrophysics Data System (ADS)

    Jing, Yingqi

    2017-07-01

    Exploring the relationships between structural rules and their linearization constraints have been a central issue in formal syntax and linguistic typology [1]. Liu et al. give a historical overview of the investigation of dependency distance minimization (DDM) in various fields, and specify its potential connections with the graphic patterns of syntactic structure and the linear ordering of words and constituents in real sentences [2]. This comment focuses on discussing the relations between dependency distance (DD), hierarchical structure and word order, and advocates further study on the coevolution of these traits in language histories.

  13. Modelling multi-protein complexes using PELDOR distance measurements for rigid body minimisation experiments using XPLOR-NIH

    PubMed Central

    Hammond, Colin M.; Owen-Hughes, Tom; Norman, David G.

    2014-01-01

    Crystallographic and NMR approaches have provided a wealth of structural information about protein domains. However, often these domains are found as components of larger multi domain polypeptides or complexes. Orienting domains within such contexts can provide powerful new insight into their function. The combination of site specific spin labelling and Pulsed Electron Double Resonance (PELDOR) provide a means of obtaining structural measurements that can be used to generate models describing how such domains are oriented. Here we describe a pipeline for modelling the location of thio-reactive nitroxyl spin locations to engineered sties on the histone chaperone Vps75. We then use a combination of experimentally determined measurements and symmetry constraints to model the orientation in which homodimers of Vps75 associate to form homotetramers using the XPLOR-NIH platform. This provides a working example of how PELDOR measurements can be used to generate a structural model. PMID:25448300

  14. Routing and Scheduling Optimization Model of Sea Transportation

    NASA Astrophysics Data System (ADS)

    barus, Mika debora br; asyrafy, Habib; nababan, Esther; mawengkang, Herman

    2018-01-01

    This paper examines the routing and scheduling optimization model of sea transportation. One of the issues discussed is about the transportation of ships carrying crude oil (tankers) which is distributed to many islands. The consideration is the cost of transportation which consists of travel costs and the cost of layover at the port. Crude oil to be distributed consists of several types. This paper develops routing and scheduling model taking into consideration some objective functions and constraints. The formulation of the mathematical model analyzed is to minimize costs based on the total distance visited by the tanker and minimize the cost of the ports. In order for the model of the problem to be more realistic and the cost calculated to be more appropriate then added a parameter that states the multiplier factor of cost increases as the charge of crude oil is filled.

  15. PROBING THE EXPANSION HISTORY OF THE UNIVERSE BY MODEL-INDEPENDENT RECONSTRUCTION FROM SUPERNOVAE AND GAMMA-RAY BURST MEASUREMENTS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Feng, Chao-Jun; Li, Xin-Zhou, E-mail: fengcj@shnu.edu.cn, E-mail: kychz@shnu.edu.cn

    To probe the late evolution history of the universe, we adopt two kinds of optimal basis systems. One of them is constructed by performing the principle component analysis, and the other is built by taking the multidimensional scaling approach. Cosmological observables such as the luminosity distance can be decomposed into these basis systems. These basis systems are optimized for different kinds of cosmological models that are based on different physical assumptions, even for a mixture model of them. Therefore, the so-called feature space that is projected from the basis systems is cosmological model independent, and it provides a parameterization for studying and reconstructing themore » Hubble expansion rate from the supernova luminosity distance and even gamma-ray burst (GRB) data with self-calibration. The circular problem when using GRBs as cosmological candles is naturally eliminated in this procedure. By using the Levenberg–Marquardt technique and the Markov Chain Monte Carlo method, we perform an observational constraint on this kind of parameterization. The data we used include the “joint light-curve analysis” data set that consists of 740 Type Ia supernovae and 109 long GRBs with the well-known Amati relation.« less

  16. On the Progenitor of Binary Neutron Star Merger GW170817

    NASA Astrophysics Data System (ADS)

    Abbott, B. P.; Abbott, R.; Abbott, T. D.; Acernese, F.; Ackley, K.; Adams, C.; Adams, T.; Addesso, P.; Adhikari, R. X.; Adya, V. B.; Affeldt, C.; Afrough, M.; Agarwal, B.; Agathos, M.; Agatsuma, K.; Aggarwal, N.; Aguiar, O. D.; Aiello, L.; Ain, A.; Ajith, P.; Allen, B.; Allen, G.; Allocca, A.; Altin, P. A.; Amato, A.; Ananyeva, A.; Anderson, S. B.; Anderson, W. G.; Angelova, S. V.; Antier, S.; Appert, S.; Arai, K.; Araya, M. C.; Areeda, J. S.; Arnaud, N.; Arun, K. G.; Ascenzi, S.; Ashton, G.; Ast, M.; Aston, S. M.; Astone, P.; Atallah, D. V.; Aufmuth, P.; Aulbert, C.; AultONeal, K.; Austin, C.; Avila-Alvarez, A.; Babak, S.; Bacon, P.; Bader, M. K. M.; Bae, S.; Baker, P. T.; Baldaccini, F.; Ballardin, G.; Ballmer, S. W.; Banagiri, S.; Barayoga, J. C.; Barclay, S. E.; Barish, B. C.; Barker, D.; Barkett, K.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barta, D.; Bartlett, J.; Bartos, I.; Bassiri, R.; Basti, A.; Batch, J. C.; Bawaj, M.; Bayley, J. C.; Bazzan, M.; Bécsy, B.; Beer, C.; Bejger, M.; Belahcene, I.; Bell, A. S.; Berger, B. K.; Bergmann, G.; Bero, J. J.; Berry, C. P. L.; Bersanetti, D.; Bertolini, A.; Betzwieser, J.; Bhagwat, S.; Bhandare, R.; Bilenko, I. A.; Billingsley, G.; Billman, C. R.; Birch, J.; Birney, R.; Birnholtz, O.; Biscans, S.; Biscoveanu, S.; Bisht, A.; Bitossi, M.; Biwer, C.; Bizouard, M. A.; Blackburn, J. K.; Blackman, J.; Blair, C. D.; Blair, D. G.; Blair, R. M.; Bloemen, S.; Bock, O.; Bode, N.; Boer, M.; Bogaert, G.; Bohe, A.; Bondu, F.; Bonilla, E.; Bonnand, R.; Boom, B. A.; Bork, R.; Boschi, V.; Bose, S.; Bossie, K.; Bouffanais, Y.; Bozzi, A.; Bradaschia, C.; Brady, P. R.; Branchesi, M.; Brau, J. E.; Briant, T.; Brillet, A.; Brinkmann, M.; Brisson, V.; Brockill, P.; Broida, J. E.; Brooks, A. F.; Brown, D. D.; Brunett, S.; Buchanan, C. C.; Buikema, A.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Buskulic, D.; Buy, C.; Byer, R. L.; Cabero, M.; Cadonati, L.; Cagnoli, G.; Cahillane, C.; Calderón Bustillo, J.; Callister, T. A.; Calloni, E.; Camp, J. B.; Canepa, M.; Canizares, P.; Cannon, K. C.; Cao, H.; Cao, J.; Capano, C. D.; Capocasa, E.; Carbognani, F.; Caride, S.; Carney, M. F.; Casanueva Diaz, J.; Casentini, C.; Caudill, S.; Cavaglià, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C. B.; Cerdá-Durán, P.; Cerretani, G.; Cesarini, E.; Chamberlin, S. J.; Chan, M.; Chao, S.; Charlton, P.; Chase, E.; Chassande-Mottin, E.; Chatterjee, D.; Cheeseboro, B. D.; Chen, H. Y.; Chen, X.; Chen, Y.; Cheng, H.-P.; Chia, H.; Chincarini, A.; Chiummo, A.; Chmiel, T.; Cho, H. S.; Cho, M.; Chow, J. H.; Christensen, N.; Chu, Q.; Chua, A. J. K.; Chua, S.; Chung, A. K. W.; Chung, S.; Ciani, G.; Ciolfi, R.; Cirelli, C. E.; Cirone, A.; Clara, F.; Clark, J. A.; Clearwater, P.; Cleva, F.; Cocchieri, C.; Coccia, E.; Cohadon, P.-F.; Cohen, D.; Colla, A.; Collette, C. G.; Cominsky, L. R.; Constancio, M., Jr.; Conti, L.; Cooper, S. J.; Corban, P.; Corbitt, T. R.; Cordero-Carrión, I.; Corley, K. R.; Corsi, A.; Cortese, S.; Costa, C. A.; Coughlin, M. W.; Coughlin, S. B.; Coulon, J.-P.; Countryman, S. T.; Couvares, P.; Covas, P. B.; Cowan, E. E.; Coward, D. M.; Cowart, M. J.; Coyne, D. C.; Coyne, R.; Creighton, J. D. E.; Creighton, T. D.; Cripe, J.; Crowder, S. G.; Cullen, T. J.; Cumming, A.; Cunningham, L.; Cuoco, E.; Dal Canton, T.; Dálya, G.; Danilishin, S. L.; D'Antonio, S.; Danzmann, K.; Dasgupta, A.; Da Silva Costa, C. F.; Dattilo, V.; Dave, I.; Davier, M.; Davis, D.; Daw, E. J.; Day, B.; De, S.; DeBra, D.; Degallaix, J.; De Laurentis, M.; Deléglise, S.; Del Pozzo, W.; Demos, N.; Denker, T.; Dent, T.; De Pietri, R.; Dergachev, V.; De Rosa, R.; DeRosa, R. T.; De Rossi, C.; DeSalvo, R.; de Varona, O.; Devenson, J.; Dhurandhar, S.; Díaz, M. C.; Di Fiore, L.; Di Giovanni, M.; Di Girolamo, T.; Di Lieto, A.; Di Pace, S.; Di Palma, I.; Di Renzo, F.; Doctor, Z.; Dolique, V.; Donovan, F.; Dooley, K. L.; Doravari, S.; Dorrington, I.; Douglas, R.; Dovale Álvarez, M.; Downes, T. P.; Drago, M.; Dreissigacker, C.; Driggers, J. C.; Du, Z.; Ducrot, M.; Dupej, P.; Dwyer, S. E.; Edo, T. B.; Edwards, M. C.; Effler, A.; Eggenstein, H.-B.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Eisenstein, R. A.; Essick, R. C.; Estevez, D.; Etienne, Z. B.; Etzel, T.; Evans, M.; Evans, T. M.; Factourovich, M.; Fafone, V.; Fair, H.; Fairhurst, S.; Fan, X.; Farinon, S.; Farr, B.; Farr, W. M.; Fauchon-Jones, E. J.; Favata, M.; Fays, M.; Fee, C.; Fehrmann, H.; Feicht, J.; Fejer, M. M.; Fernandez-Galiana, A.; Ferrante, I.; Ferreira, E. C.; Ferrini, F.; Fidecaro, F.; Finstad, D.; Fiori, I.; Fiorucci, D.; Fishbach, M.; Fisher, R. P.; Fitz-Axen, M.; Flaminio, R.; Fletcher, M.; Fong, H.; Font, J. A.; Forsyth, P. W. F.; Forsyth, S. S.; Fournier, J.-D.; Frasca, S.; Frasconi, F.; Frei, Z.; Freise, A.; Frey, R.; Frey, V.; Fries, E. M.; Fritschel, P.; Frolov, V. V.; Fulda, P.; Fyffe, M.; Gabbard, H.; Gadre, B. U.; Gaebel, S. M.; Gair, J. R.; Gammaitoni, L.; Ganija, M. R.; Gaonkar, S. G.; Garcia-Quiros, C.; Garufi, F.; Gateley, B.; Gaudio, S.; Gaur, G.; Gayathri, V.; Gehrels, N.; Gemme, G.; Genin, E.; Gennai, A.; George, D.; George, J.; Gergely, L.; Germain, V.; Ghonge, S.; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, S.; Giaime, J. A.; Giardina, K. D.; Giazotto, A.; Gill, K.; Glover, L.; Goetz, E.; Goetz, R.; Gomes, S.; Goncharov, B.; Gonzalez Castro, J. M.; Gopakumar, A.; Gorodetsky, M. L.; Gossan, S. E.; Gosselin, M.; Gouaty, R.; Grado, A.; Graef, C.; Granata, M.; Grant, A.; Gras, S.; Gray, C.; Greco, G.; Green, A. C.; Gretarsson, E. M.; Groot, P.; Grote, H.; Grunewald, S.; Gruning, P.; Guidi, G. M.; Guo, X.; Gupta, A.; Gupta, M. K.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Halim, O.; Hall, B. R.; Hall, E. D.; Hamilton, E. Z.; Hammond, G.; Haney, M.; Hanke, M. M.; Hanks, J.; Hanna, C.; Hannam, M. D.; Hannuksela, O. A.; Hanson, J.; Hardwick, T.; Harms, J.; Harry, G. M.; Harry, I. W.; Hart, M. J.; Haster, C.-J.; Haughian, K.; Healy, J.; Heidmann, A.; Heintze, M. C.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M.; Heng, I. S.; Hennig, J.; Heptonstall, A. W.; Heurs, M.; Hild, S.; Hinderer, T.; Hoak, D.; Hofman, D.; Holgado, A. M.; Holt, K.; Holz, D. E.; Hopkins, P.; Horst, C.; Hough, J.; Houston, E. A.; Howell, E. J.; Hreibi, A.; Hu, Y. M.; Huerta, E. A.; Huet, D.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh-Dinh, T.; Indik, N.; Inta, R.; Intini, G.; Isa, H. N.; Isac, J.-M.; Isi, M.; Iyer, B. R.; Izumi, K.; Jacqmin, T.; Jani, K.; Jaranowski, P.; Jawahar, S.; Jiménez-Forteza, F.; Johnson, W. W.; Jones, D. I.; Jones, R.; Jonker, R. J. G.; Ju, L.; Junker, J.; Kalaghatgi, C. V.; Kalogera, V.; Kamai, B.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Kapadia, S. J.; Karki, S.; Karvinen, K. S.; Kasprzack, M.; Katolik, M.; Katsavounidis, E.; Katzman, W.; Kaufer, S.; Kawabe, K.; Kéfélian, F.; Keitel, D.; Kemball, A. J.; Kennedy, R.; Kent, C.; Key, J. S.; Khalili, F. Y.; Khan, I.; Khan, S.; Khan, Z.; Khazanov, E. A.; Kijbunchoo, N.; Kim, Chunglee; Kim, J. C.; Kim, K.; Kim, W.; Kim, W. S.; Kim, Y.-M.; Kimball, C.; Kimbrell, S. J.; King, E. J.; King, P. J.; Kinley-Hanlon, M.; Kirchhoff, R.; Kissel, J. S.; Kleybolte, L.; Klimenko, S.; Knowles, T. D.; Koch, P.; Koehlenbeck, S. M.; Koley, S.; Kondrashov, V.; Kontos, A.; Korobko, M.; Korth, W. Z.; Kowalska, I.; Kozak, D. B.; Krämer, C.; Kringel, V.; Królak, A.; Kuehn, G.; Kumar, P.; Kumar, R.; Kumar, S.; Kuo, L.; Kutynia, A.; Kwang, S.; Lackey, B. D.; Lai, K. H.; Landry, M.; Lang, R. N.; Lange, J.; Lantz, B.; Lanza, R. K.; Larson, S. L.; Lartaux-Vollard, A.; Lasky, P. D.; Laxen, M.; Lazzarini, A.; Lazzaro, C.; Leaci, P.; Leavey, S.; Lee, C. H.; Lee, H. K.; Lee, H. M.; Lee, H. W.; Lee, K.; Lehmann, J.; Lenon, A.; Leonardi, M.; Leroy, N.; Letendre, N.; Levin, Y.; Li, T. G. F.; Linker, S. D.; Littenberg, T. B.; Liu, J.; Lo, R. K. L.; Lockerbie, N. A.; London, L. T.; Lord, J. E.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J. D.; Lousto, C. O.; Lovelace, G.; Lück, H.; Lumaca, D.; Lundgren, A. P.; Lynch, R.; Ma, Y.; Macas, R.; Macfoy, S.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Magaña Hernandez, I.; Magaña-Sandoval, F.; Magaña Zertuche, L.; Magee, R. M.; Majorana, E.; Maksimovic, I.; Man, N.; Mandic, V.; Mangano, V.; Mansell, G. L.; Manske, M.; Mantovani, M.; Marchesoni, F.; Marion, F.; Márka, S.; Márka, Z.; Markakis, C.; Markosyan, A. S.; Markowitz, A.; Maros, E.; Marquina, A.; Martelli, F.; Martellini, L.; Martin, I. W.; Martin, R. M.; Martynov, D. V.; Mason, K.; Massera, E.; Masserot, A.; Massinger, T. J.; Masso-Reid, M.; Mastrogiovanni, S.; Matas, A.; Matichard, F.; Matone, L.; Mavalvala, N.; Mazumder, N.; McCarthy, R.; McClelland, D. E.; McCormick, S.; McCuller, L.; McGuire, S. C.; McIntyre, G.; McIver, J.; McManus, D. J.; McNeill, L.; McRae, T.; McWilliams, S. T.; Meacher, D.; Meadors, G. D.; Mehmet, M.; Meidam, J.; Mejuto-Villa, E.; Melatos, A.; Mendell, G.; Mercer, R. A.; Merilh, E. L.; Merzougui, M.; Meshkov, S.; Messenger, C.; Messick, C.; Metzdorff, R.; Meyers, P. M.; Miao, H.; Michel, C.; Middleton, H.; Mikhailov, E. E.; Milano, L.; Miller, A. L.; Miller, B. B.; Miller, J.; Millhouse, M.; Milovich-Goff, M. C.; Minazzoli, O.; Minenkov, Y.; Ming, J.; Mishra, C.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moffa, D.; Moggi, A.; Mogushi, K.; Mohan, M.; Mohapatra, S. R. P.; Montani, M.; Moore, C. J.; Moraru, D.; Moreno, G.; Morriss, S. R.; Mours, B.; Mow-Lowry, C. M.; Mueller, G.; Muir, A. W.; Mukherjee, Arunava; Mukherjee, D.; Mukherjee, S.; Mukund, N.; Mullavey, A.; Munch, J.; Muñiz, E. A.; Muratore, M.; Murray, P. G.; Napier, K.; Nardecchia, I.; Naticchioni, L.; Nayak, R. K.; Neilson, J.; Nelemans, G.; Nelson, T. J. N.; Nery, M.; Neunzert, A.; Nevin, L.; Newport, J. M.; Newton, G.; Ng, K. K. Y.; Nguyen, T. T.; Nichols, D.; Nielsen, A. B.; Nissanke, S.; Nitz, A.; Noack, A.; Nocera, F.; Nolting, D.; North, C.; Nuttall, L. K.; Oberling, J.; O'Dea, G. D.; Ogin, G. H.; Oh, J. J.; Oh, S. H.; Ohme, F.; Okada, M. A.; Oliver, M.; Oppermann, P.; Oram, Richard J.; O'Reilly, B.; Ormiston, R.; Ortega, L. F.; O'Shaughnessy, R.; Ossokine, S.; Ottaway, D. J.; Overmier, H.; Owen, B. J.; Pace, A. E.; Page, J.; Page, M. A.; Pai, A.; Pai, S. A.; Palamos, J. R.; Palashov, O.; Palomba, C.; Pal-Singh, A.; Pan, Howard; Pan, Huang-Wei; Pang, B.; Pang, P. T. H.; Pankow, C.; Pannarale, F.; Pant, B. C.; Paoletti, F.; Paoli, A.; Papa, M. A.; Parida, A.; Parker, W.; Pascucci, D.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Patil, M.; Patricelli, B.; Pearlstone, B. L.; Pedraza, M.; Pedurand, R.; Pekowsky, L.; Pele, A.; Penn, S.; Perez, C. J.; Perreca, A.; Perri, L. M.; Pfeiffer, H. P.; Phelps, M.; Piccinni, O. J.; Pichot, M.; Piergiovanni, F.; Pierro, V.; Pillant, G.; Pinard, L.; Pinto, I. M.; Pirello, M.; Pitkin, M.; Poe, M.; Poggiani, R.; Popolizio, P.; Porter, E. K.; Post, A.; Powell, J.; Prasad, J.; Pratt, J. W. W.; Pratten, G.; Predoi, V.; Prestegard, T.; Prijatelj, M.; Principe, M.; Privitera, S.; Prodi, G. A.; Prokhorov, L. G.; Puncken, O.; Punturo, M.; Puppo, P.; Pürrer, M.; Qi, H.; Quetschke, V.; Quintero, E. A.; Quitzow-James, R.; Rabeling, D. S.; Radkins, H.; Raffai, P.; Raja, S.; Rajan, C.; Rajbhandari, B.; Rakhmanov, M.; Ramirez, K. E.; Ramos-Buades, A.; Rapagnani, P.; Raymond, V.; Razzano, M.; Read, J.; Regimbau, T.; Rei, L.; Reid, S.; Reitze, D. H.; Ren, W.; Reyes, S. D.; Ricci, F.; Ricker, P. M.; Rieger, S.; Riles, K.; Rizzo, M.; Robertson, N. A.; Robie, R.; Robinet, F.; Rocchi, A.; Rolland, L.; Rollins, J. G.; Roma, V. J.; Romano, R.; Romel, C. L.; Romie, J. H.; Rosińska, D.; Ross, M. P.; Rowan, S.; Rüdiger, A.; Ruggi, P.; Rutins, G.; Ryan, K.; Sachdev, S.; Sadecki, T.; Sadeghian, L.; Sakellariadou, M.; Salconi, L.; Saleem, M.; Salemi, F.; Samajdar, A.; Sammut, L.; Sampson, L. M.; Sanchez, E. J.; Sanchez, L. E.; Sanchis-Gual, N.; Sandberg, V.; Sanders, J. R.; Sassolas, B.; Sathyaprakash, B. S.; Sauter, O.; Savage, R. L.; Sawadsky, A.; Schale, P.; Scheel, M.; Scheuer, J.; Schmidt, J.; Schmidt, P.; Schnabel, R.; Schofield, R. M. S.; Schönbeck, A.; Schreiber, E.; Schuette, D.; Schulte, B. W.; Schutz, B. F.; Schwalbe, S. G.; Scott, J.; Scott, S. M.; Seidel, E.; Sellers, D.; Sengupta, A. S.; Sentenac, D.; Sequino, V.; Sergeev, A.; Shaddock, D. A.; Shaffer, T. J.; Shah, A. A.; Shahriar, M. S.; Shaner, M. B.; Shao, L.; Shapiro, B.; Shawhan, P.; Sheperd, A.; Shoemaker, D. H.; Shoemaker, D. M.; Siellez, K.; Siemens, X.; Sieniawska, M.; Sigg, D.; Silva, A. D.; Singer, L. P.; Singh, A.; Singhal, A.; Sintes, A. M.; Slagmolen, B. J. J.; Smith, B.; Smith, J. R.; Smith, R. J. E.; Somala, S.; Son, E. J.; Sonnenberg, J. A.; Sorazu, B.; Sorrentino, F.; Souradeep, T.; Spencer, A. P.; Srivastava, A. K.; Staats, K.; Staley, A.; Steinke, M.; Steinlechner, J.; Steinlechner, S.; Steinmeyer, D.; Stevenson, S. P.; Stone, R.; Stops, D. J.; Strain, K. A.; Stratta, G.; Strigin, S. E.; Strunk, A.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Sun, L.; Sunil, S.; Suresh, J.; Sutton, P. J.; Swinkels, B. L.; Szczepańczyk, M. J.; Tacca, M.; Tait, S. C.; Talbot, C.; Talukder, D.; Tanner, D. B.; Tápai, M.; Taracchini, A.; Tasson, J. D.; Taylor, J. A.; Taylor, R.; Tewari, S. V.; Theeg, T.; Thies, F.; Thomas, E. G.; Thomas, M.; Thomas, P.; Thorne, K. A.; Thrane, E.; Tiwari, S.; Tiwari, V.; Tokmakov, K. V.; Toland, K.; Tonelli, M.; Tornasi, Z.; Torres-Forné, A.; Torrie, C. I.; Töyrä, D.; Travasso, F.; Traylor, G.; Trinastic, J.; Tringali, M. C.; Trozzo, L.; Tsang, K. W.; Tse, M.; Tso, R.; Tsukada, L.; Tsuna, D.; Tuyenbayev, D.; Ueno, K.; Ugolini, D.; Unnikrishnan, C. S.; Urban, A. L.; Usman, S. A.; Vahlbruch, H.; Vajente, G.; Valdes, G.; van Bakel, N.; van Beuzekom, M.; van den Brand, J. F. J.; Van Den Broeck, C.; Vander-Hyde, D. C.; van der Schaaf, L.; van Heijningen, J. V.; van Veggel, A. A.; Vardaro, M.; Varma, V.; Vass, S.; Vasúth, M.; Vecchio, A.; Vedovato, G.; Veitch, J.; Veitch, P. J.; Venkateswara, K.; Venugopalan, G.; Verkindt, D.; Vetrano, F.; Viceré, A.; Viets, A. D.; Vinciguerra, S.; Vine, D. J.; Vinet, J.-Y.; Vitale, S.; Vo, T.; Vocca, H.; Vorvick, C.; Vyatchanin, S. P.; Wade, A. R.; Wade, L. E.; Wade, M.; Walet, R.; Walker, M.; Wallace, L.; Walsh, S.; Wang, G.; Wang, H.; Wang, J. Z.; Wang, W. H.; Wang, Y. F.; Ward, R. L.; Warner, J.; Was, M.; Watchi, J.; Weaver, B.; Wei, L.-W.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Wen, L.; Wessel, E. K.; Weßels, P.; Westerweck, J.; Westphal, T.; Wette, K.; Whelan, J. T.; Whiting, B. F.; Whittle, C.; Wilken, D.; Williams, D.; Williams, R. D.; Williamson, A. R.; Willis, J. L.; Willke, B.; Wimmer, M. H.; Winkler, W.; Wipf, C. C.; Wittel, H.; Woan, G.; Woehler, J.; Wofford, J.; Wong, K. W. K.; Worden, J.; Wright, J. L.; Wu, D. S.; Wysocki, D. M.; Xiao, S.; Yamamoto, H.; Yancey, C. C.; Yang, L.; Yap, M. J.; Yazback, M.; Yu, Hang; Yu, Haocun; Yvert, M.; Zadrożny, A.; Zanolin, M.; Zelenova, T.; Zendri, J.-P.; Zevin, M.; Zhang, L.; Zhang, M.; Zhang, T.; Zhang, Y.-H.; Zhao, C.; Zhou, M.; Zhou, Z.; Zhu, S. J.; Zhu, X. J.; Zucker, M. E.; Zweizig, J.; (LIGO Scientific Collaboration; Virgo Collaboration

    2017-12-01

    On 2017 August 17 the merger of two compact objects with masses consistent with two neutron stars was discovered through gravitational-wave (GW170817), gamma-ray (GRB 170817A), and optical (SSS17a/AT 2017gfo) observations. The optical source was associated with the early-type galaxy NGC 4993 at a distance of just ˜40 Mpc, consistent with the gravitational-wave measurement, and the merger was localized to be at a projected distance of ˜2 kpc away from the galaxy’s center. We use this minimal set of facts and the mass posteriors of the two neutron stars to derive the first constraints on the progenitor of GW170817 at the time of the second supernova (SN). We generate simulated progenitor populations and follow the three-dimensional kinematic evolution from binary neutron star (BNS) birth to the merger time, accounting for pre-SN galactic motion, for considerably different input distributions of the progenitor mass, pre-SN semimajor axis, and SN-kick velocity. Though not considerably tight, we find these constraints to be comparable to those for Galactic BNS progenitors. The derived constraints are very strongly influenced by the requirement of keeping the binary bound after the second SN and having the merger occur relatively close to the center of the galaxy. These constraints are insensitive to the galaxy’s star formation history, provided the stellar populations are older than 1 Gyr.

  17. Permian deposition in the north central Brooks Range, Alaska Constraints for tectonic reconstructions

    USGS Publications Warehouse

    Adams, K.E.; Mull, C.G.; Crowder, R.K.

    1997-01-01

    Two opposing tectonic models have been offered to explain the regional structural relations in the north central Brooks Range fold-thrust belt of northern Alaska. The first suggests that rocks of the northern Endicott Mountains were thrust from south to north over the area of the present Mount Doonerak high and are therefore highly allochthonous. The second implies that the rocks of the northern Endicott Mountains were deposited in a basin that lay north of the Mount Doonerak high and later were thrust a short distance southward onto the northern flank of the high and are thus parautochthonous. To provide stratigraphic constraints for these models, this study examines Permian facies of the north central Brooks Range. Permian rocks in the north central Brooks Range comprise a thin (40 to 160 m thick), fining-upward succession of clastic, storm-influenced shelf deposits. When the rocks of the northern Endicott Mountains are restored south of the Mount Doonerak area, a minimum distance of 80 km, the Permian deposits grade systematically from distal facies (Siksikpuk Formation) in the southwest to proximal facies (Echooka Formation) in the northeast. Facies trends in the reconstructed Permian basin include, from southwest to northeast, (1) an increase in carbonate content and corresponding decrease in silica content, (2) a general darkening and thickening of shaley intervals, (3) an increase in proximal features of storm beds, including coarser, thicker, more abundant, and more closely spaced beds, and (4) an increase in abundance and diversity of the faunal assemblage with a corresponding decrease in age. These stratigraphic relations imply that rocks of the northern Endicott Mountains are allochthonous and structurally overlie a proximal stratigraphic succession similar to that exposed in the Mount Doonerak area and northeastern Brooks Range. Copyright 1997 by the American Geophysical Union.

  18. An Improved Method to Measure the Cosmic Curvature

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wei, Jun-Jie; Wu, Xue-Feng, E-mail: jjwei@pmo.ac.cn

    2017-04-01

    In this paper, we propose an improved model-independent method to constrain the cosmic curvature by combining the most recent Hubble parameter H ( z ) and supernovae Ia (SNe Ia) data. Based on the H ( z ) data, we first use the model-independent smoothing technique, Gaussian processes, to construct a distance modulus μ {sub H} ( z ), which is susceptible to the cosmic curvature parameter Ω{sub k}. In contrary to previous studies, the light-curve-fitting parameters, which account for the distance estimation of SN (μ {sub SN}( z )), are set free to investigate whether Ω {sub k} hasmore » a dependence on them. By comparing μ {sub H} ( z ) to μ {sub SN}(z), we put limits on Ω {sub k}. Our results confirm that Ω {sub k} is independent of the SN light-curve parameters. Moreover, we show that the measured Ω {sub k} is in good agreement with zero cosmic curvature, implying that there is no significant deviation from a flat universe at the current observational data level. We also test the influence of different H(z) samples and different Hubble constant H {sub 0} values, finding that different H(z) samples do not have a significant impact on the constraints. However, different H {sub 0} priors can affect the constraints of Ω {sub k} to some degree. The prior of H {sub 0} = 73.24 ± 1.74 km s{sup −1} Mpc{sup −1} gives a value of Ω {sub k}, a little bit above the 1 σ confidence level away from 0, but H{sub 0} = 69.6 ± 0.7 km s{sup −1} Mpc{sup −1} gives it below 1 σ .« less

  19. The clustering of galaxies in the completed SDSS-III Baryon Oscillation Spectroscopic Survey: cosmological analysis of the DR12 galaxy sample

    NASA Astrophysics Data System (ADS)

    Alam, Shadab; Ata, Metin; Bailey, Stephen; Beutler, Florian; Bizyaev, Dmitry; Blazek, Jonathan A.; Bolton, Adam S.; Brownstein, Joel R.; Burden, Angela; Chuang, Chia-Hsun; Comparat, Johan; Cuesta, Antonio J.; Dawson, Kyle S.; Eisenstein, Daniel J.; Escoffier, Stephanie; Gil-Marín, Héctor; Grieb, Jan Niklas; Hand, Nick; Ho, Shirley; Kinemuchi, Karen; Kirkby, David; Kitaura, Francisco; Malanushenko, Elena; Malanushenko, Viktor; Maraston, Claudia; McBride, Cameron K.; Nichol, Robert C.; Olmstead, Matthew D.; Oravetz, Daniel; Padmanabhan, Nikhil; Palanque-Delabrouille, Nathalie; Pan, Kaike; Pellejero-Ibanez, Marcos; Percival, Will J.; Petitjean, Patrick; Prada, Francisco; Price-Whelan, Adrian M.; Reid, Beth A.; Rodríguez-Torres, Sergio A.; Roe, Natalie A.; Ross, Ashley J.; Ross, Nicholas P.; Rossi, Graziano; Rubiño-Martín, Jose Alberto; Saito, Shun; Salazar-Albornoz, Salvador; Samushia, Lado; Sánchez, Ariel G.; Satpathy, Siddharth; Schlegel, David J.; Schneider, Donald P.; Scóccola, Claudia G.; Seo, Hee-Jong; Sheldon, Erin S.; Simmons, Audrey; Slosar, Anže; Strauss, Michael A.; Swanson, Molly E. C.; Thomas, Daniel; Tinker, Jeremy L.; Tojeiro, Rita; Magaña, Mariana Vargas; Vazquez, Jose Alberto; Verde, Licia; Wake, David A.; Wang, Yuting; Weinberg, David H.; White, Martin; Wood-Vasey, W. Michael; Yèche, Christophe; Zehavi, Idit; Zhai, Zhongxu; Zhao, Gong-Bo

    2017-09-01

    We present cosmological results from the final galaxy clustering data set of the Baryon Oscillation Spectroscopic Survey, part of the Sloan Digital Sky Survey III. Our combined galaxy sample comprises 1.2 million massive galaxies over an effective area of 9329 deg2 and volume of 18.7 Gpc3, divided into three partially overlapping redshift slices centred at effective redshifts 0.38, 0.51 and 0.61. We measure the angular diameter distance DM and Hubble parameter H from the baryon acoustic oscillation (BAO) method, in combination with a cosmic microwave background prior on the sound horizon scale, after applying reconstruction to reduce non-linear effects on the BAO feature. Using the anisotropic clustering of the pre-reconstruction density field, we measure the product DMH from the Alcock-Paczynski (AP) effect and the growth of structure, quantified by fσ8(z), from redshift-space distortions (RSD). We combine individual measurements presented in seven companion papers into a set of consensus values and likelihoods, obtaining constraints that are tighter and more robust than those from any one method; in particular, the AP measurement from sub-BAO scales sharpens constraints from post-reconstruction BAOs by breaking degeneracy between DM and H. Combined with Planck 2016 cosmic microwave background measurements, our distance scale measurements simultaneously imply curvature ΩK = 0.0003 ± 0.0026 and a dark energy equation-of-state parameter w = -1.01 ± 0.06, in strong affirmation of the spatially flat cold dark matter (CDM) model with a cosmological constant (ΛCDM). Our RSD measurements of fσ8, at 6 per cent precision, are similarly consistent with this model. When combined with supernova Ia data, we find H0 = 67.3 ± 1.0 km s-1 Mpc-1 even for our most general dark energy model, in tension with some direct measurements. Adding extra relativistic species as a degree of freedom loosens the constraint only slightly, to H0 = 67.8 ± 1.2 km s-1 Mpc-1. Assuming flat ΛCDM, we find Ωm = 0.310 ± 0.005 and H0 = 67.6 ± 0.5 km s-1 Mpc-1, and we find a 95 per cent upper limit of 0.16 eV c-2 on the neutrino mass sum.

  20. Joint inversion of surface wave dispersion and receiver functions for crustal structure in Oklahoma

    NASA Astrophysics Data System (ADS)

    Guo, Hao

    The surge in seismicity in Oklahoma starting in 2008 raises questions about the actual locations of the earthquakes in the upper crust. The key to answering this is an improved crustal model that explains as many observations as possible. Love and Rayleigh wave dispersion, teleseismic P-wave receiver functions and some unique transverse motions observed at distances less than 100 km that are characteristics of rays reverberating in a basin provide data to derive the crustal model. The surface wave dispersion data set consists of over 300,000 Love/Rayleigh phase/group values obtained from ambient noise cross-correlation of BH channels of the 133 Transportable Array (TA) stations of Earthscope to periods as short as 2 seconds. Station coverage is dense enough to perform the tomography on a 25*25 km grid that should be able to image shallow geological structures. In addition, receiver functions were obtained using teleseismic data recorded from 3 US Geological Survey Networks (GS) stations and 6 Oklahoma Seismic Network (OK) stations from 2011 to 2014. The 1-D S-wave velocity models derived by the joint inversion of surface wave dispersion and receiver functions with geological constraints are tested by fitting the independent transverse seismograms. This test also provides constraints on the earthquake depths in relation to the geological structure.

  1. Cooperative Scheduling of Imaging Observation Tasks for High-Altitude Airships Based on Propagation Algorithm

    PubMed Central

    Chuan, He; Dishan, Qiu; Jin, Liu

    2012-01-01

    The cooperative scheduling problem on high-altitude airships for imaging observation tasks is discussed. A constraint programming model is established by analyzing the main constraints, which takes the maximum task benefit and the minimum cruising distance as two optimization objectives. The cooperative scheduling problem of high-altitude airships is converted into a main problem and a subproblem by adopting hierarchy architecture. The solution to the main problem can construct the preliminary matching between tasks and observation resource in order to reduce the search space of the original problem. Furthermore, the solution to the sub-problem can detect the key nodes that each airship needs to fly through in sequence, so as to get the cruising path. Firstly, the task set is divided by using k-core neighborhood growth cluster algorithm (K-NGCA). Then, a novel swarm intelligence algorithm named propagation algorithm (PA) is combined with the key node search algorithm (KNSA) to optimize the cruising path of each airship and determine the execution time interval of each task. Meanwhile, this paper also provides the realization approach of the above algorithm and especially makes a detailed introduction on the encoding rules, search models, and propagation mechanism of the PA. Finally, the application results and comparison analysis show the proposed models and algorithms are effective and feasible. PMID:23365522

  2. A Framework of Covariance Projection on Constraint Manifold for Data Fusion.

    PubMed

    Bakr, Muhammad Abu; Lee, Sukhan

    2018-05-17

    A general framework of data fusion is presented based on projecting the probability distribution of true states and measurements around the predicted states and actual measurements onto the constraint manifold. The constraint manifold represents the constraints to be satisfied among true states and measurements, which is defined in the extended space with all the redundant sources of data such as state predictions and measurements considered as independent variables. By the general framework, we mean that it is able to fuse any correlated data sources while directly incorporating constraints and identifying inconsistent data without any prior information. The proposed method, referred to here as the Covariance Projection (CP) method, provides an unbiased and optimal solution in the sense of minimum mean square error (MMSE), if the projection is based on the minimum weighted distance on the constraint manifold. The proposed method not only offers a generalization of the conventional formula for handling constraints and data inconsistency, but also provides a new insight into data fusion in terms of a geometric-algebraic point of view. Simulation results are provided to show the effectiveness of the proposed method in handling constraints and data inconsistency.

  3. Optimizing Preseason Training Loads in Australian Football.

    PubMed

    Carey, David L; Crow, Justin; Ong, Kok-Leong; Blanch, Peter; Morris, Meg E; Dascombe, Ben J; Crossley, Kay M

    2018-02-01

    To investigate whether preseason training plans for Australian football can be computer generated using current training-load guidelines to optimize injury-risk reduction and performance improvement. A constrained optimization problem was defined for daily total and sprint distance, using the preseason schedule of an elite Australian football team as a template. Maximizing total training volume and maximizing Banister-model-projected performance were both considered optimization objectives. Cumulative workload and acute:chronic workload-ratio constraints were placed on training programs to reflect current guidelines on relative and absolute training loads for injury-risk reduction. Optimization software was then used to generate preseason training plans. The optimization framework was able to generate training plans that satisfied relative and absolute workload constraints. Increasing the off-season chronic training loads enabled the optimization algorithm to prescribe higher amounts of "safe" training and attain higher projected performance levels. Simulations showed that using a Banister-model objective led to plans that included a taper in training load prior to competition to minimize fatigue and maximize projected performance. In contrast, when the objective was to maximize total training volume, more frequent training was prescribed to accumulate as much load as possible. Feasible training plans that maximize projected performance and satisfy injury-risk constraints can be automatically generated by an optimization problem for Australian football. The optimization methods allow for individualized training-plan design and the ability to adapt to changing training objectives and different training-load metrics.

  4. Is the Universe transparent?

    NASA Astrophysics Data System (ADS)

    Liao, Kai; Avgoustidis, A.; Li, Zhengxiang

    2015-12-01

    We present our study on cosmic opacity, which relates to changes in photon number as photons travel from the source to the observer. Cosmic opacity may be caused by absorption or scattering due to matter in the Universe, or by extragalactic magnetic fields that can turn photons into unobserved particles (e.g., light axions, chameleons, gravitons, Kaluza-Klein modes), and it is crucial to correctly interpret astronomical photometric measurements like type Ia supernovae observations. On the other hand, the expansion rate at different epochs, i.e., the observational Hubble parameter data H (z ), are obtained from differential ageing of passively evolving galaxies or from baryon acoustic oscillations and thus are not affected by cosmic opacity. In this work, we first construct opacity-free luminosity distances from H (z ) determinations, taking into consideration correlations between different redshifts for our error analysis. Moreover, we let the light-curve fitting parameters, accounting for distance estimation in type Ia supernovae observations, free to ensure that our analysis is authentically cosmological-model independent and gives a robust result. Any nonzero residuals between these two kinds of luminosity distances can be deemed as an indication of the existence of cosmic opacity. While a transparent Universe is currently consistent with the data, our results show that strong constraints on opacity (and consequently on physical mechanisms that could cause it) can be obtained in a cosmological-model-independent fashion.

  5. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: baryon acoustic oscillations in the correlation function of LOWZ and CMASS galaxies in Data Release 12

    DOE PAGES

    Cuesta, Antonio J.; Vargas-Magaña, Mariana; Beutler, Florian; ...

    2016-02-04

    In this paper, we present distance scale measurements from the baryon acoustic oscillation signal in the constant stellar mass and low-redshift sample samples from the Data Release 12 of the Baryon Oscillation Spectroscopic Survey. The total volume probed is 14.5 Gpc 3, a 10 per cent increment from Data Release 11. From an analysis of the spherically averaged correlation function, we infer a distance to z = 0.57 of D V(z)rmore » $$fid\\atop{d}$$ /r d = 2028 ± 21 Mpc and a distance to z = 0.32 of V(z)r$$fid\\atop{d}$$ /r d = 1264 ± 22 Mpc assuming a cosmology in which r$$fid\\atop{d}$$ = 147.10 Mpc. From the anisotropic analysis, we find an angular diameter distance to z = 0.57 of D A(z)r$$fid\\atop{d}$$ /r d = 1401 ± 21 Mpc and a distance to z = 0.32 of 981 ± 20 Mpc, a 1.5 and 2.0 per cent measurement, respectively. The Hubble parameter at z = 0.57 is H(z)r d/r$$fid\\atop{d}$$ = 100.3 ± 3.7kms -1 Mpc -1 and its value at z=0.32 is 79.2±5.6 kms -1 Mpc -1 , a 3.7 and 7.1 per cent measurement, respectively. In conclusion, these cosmic distance scale constraints are in excellent agreement with aΛcold dark matter model with cosmological parameters released by the recent Planck 2015 results.« less

  6. Dependency distance minimization in understanding of ambiguous structure. Comment on "Dependency distance: A new perspective on syntactic patterns in natural languages" by Haitao Liu et al.

    NASA Astrophysics Data System (ADS)

    Zhao, Yiyi

    2017-07-01

    Dependency Distance, proposed by Hudson [1], calculated by Liu [2,3], is an important concept in Dependency Theory. It can be used as a measure of the syntactic difficulty, and lots of research [2,4] have testified the universal of Dependency Distance in various languages. Human languages seem to present a preference for short dependency distance, which may be explained in terms of general cognitive constraint of limited working memory [5]. Psychological experiments in English, German, Russian and Chinese support the hypothesis that Dependency Distance minimization (DDM) make languages to evolve into some syntactic patterns to reduce memory burden [6-9]. The study of psychology focuses on the process and mechanism of syntactic structure selection in speech comprehension. In many speech comprehension experiments [10], ambiguous structure is an important experimental material.

  7. Assessment of auditory distance in a territorial songbird: accurate feat or rule of thumb?

    PubMed

    Naguib; Klump; Hillmann; Grießmann; Teige

    2000-04-01

    Territorial passerines presumably benefit from their ability to use auditory cues to judge the distance to singing conspecifics, by increasing the efficiency of their territorial defence. Here, we report data on the approach of male territorial chaffinches, Fringilla coelebs, to a loudspeaker broadcasting conspecific song simulating a rival at various distances by different amounts of song degradation. Songs were degraded digitally in a computer-simulated forest emulating distances of 0, 20, 40, 80 and 120 m. The approach distance of chaffinches towards the loudspeaker increased with increasing amounts of degradation indicating a perceptual representation of differences in distance of a sound source. We discuss the interindividual variation of male responses with respect to constraints resulting from random variation of ranging cues provided by the environmental song degradation, the perception accuracy and the decision rules. Copyright 2000 The Association for the Study of Animal Behaviour.

  8. Haptic spatial matching in near peripersonal space.

    PubMed

    Kaas, Amanda L; Mier, Hanneke I van

    2006-04-01

    Research has shown that haptic spatial matching at intermanual distances over 60 cm is prone to large systematic errors. The error pattern has been explained by the use of reference frames intermediate between egocentric and allocentric coding. This study investigated haptic performance in near peripersonal space, i.e. at intermanual distances of 60 cm and less. Twelve blindfolded participants (six males and six females) were presented with two turn bars at equal distances from the midsagittal plane, 30 or 60 cm apart. Different orientations (vertical/horizontal or oblique) of the left bar had to be matched by adjusting the right bar to either a mirror symmetric (/ \\) or parallel (/ /) position. The mirror symmetry task can in principle be performed accurately in both an egocentric and an allocentric reference frame, whereas the parallel task requires an allocentric representation. Results showed that parallel matching induced large systematic errors which increased with distance. Overall error was significantly smaller in the mirror task. The task difference also held for the vertical orientation at 60 cm distance, even though this orientation required the same response in both tasks, showing a marked effect of task instruction. In addition, men outperformed women on the parallel task. Finally, contrary to our expectations, systematic errors were found in the mirror task, predominantly at 30 cm distance. Based on these findings, we suggest that haptic performance in near peripersonal space might be dominated by different mechanisms than those which come into play at distances over 60 cm. Moreover, our results indicate that both inter-individual differences and task demands affect task performance in haptic spatial matching. Therefore, we conclude that the study of haptic spatial matching in near peripersonal space might reveal important additional constraints for the specification of adequate models of haptic spatial performance.

  9. Model-based metabolism design: constraints for kinetic and stoichiometric models

    PubMed Central

    Stalidzans, Egils; Seiman, Andrus; Peebo, Karl; Komasilovs, Vitalijs; Pentjuss, Agris

    2018-01-01

    The implementation of model-based designs in metabolic engineering and synthetic biology may fail. One of the reasons for this failure is that only a part of the real-world complexity is included in models. Still, some knowledge can be simplified and taken into account in the form of optimization constraints to improve the feasibility of model-based designs of metabolic pathways in organisms. Some constraints (mass balance, energy balance, and steady-state assumption) serve as a basis for many modelling approaches. There are others (total enzyme activity constraint and homeostatic constraint) proposed decades ago, but which are frequently ignored in design development. Several new approaches of cellular analysis have made possible the application of constraints like cell size, surface, and resource balance. Constraints for kinetic and stoichiometric models are grouped according to their applicability preconditions in (1) general constraints, (2) organism-level constraints, and (3) experiment-level constraints. General constraints are universal and are applicable for any system. Organism-level constraints are applicable for biological systems and usually are organism-specific, but these constraints can be applied without information about experimental conditions. To apply experimental-level constraints, peculiarities of the organism and the experimental set-up have to be taken into account to calculate the values of constraints. The limitations of applicability of particular constraints for kinetic and stoichiometric models are addressed. PMID:29472367

  10. Optimal multi-floor plant layout based on the mathematical programming and particle swarm optimization.

    PubMed

    Lee, Chang Jun

    2015-01-01

    In the fields of researches associated with plant layout optimization, the main goal is to minimize the costs of pipelines and pumping between connecting equipment under various constraints. However, what is the lacking of considerations in previous researches is to transform various heuristics or safety regulations into mathematical equations. For example, proper safety distances between equipments have to be complied for preventing dangerous accidents on a complex plant. Moreover, most researches have handled single-floor plant. However, many multi-floor plants have been constructed for the last decade. Therefore, the proper algorithm handling various regulations and multi-floor plant should be developed. In this study, the Mixed Integer Non-Linear Programming (MINLP) problem including safety distances, maintenance spaces, etc. is suggested based on mathematical equations. The objective function is a summation of pipeline and pumping costs. Also, various safety and maintenance issues are transformed into inequality or equality constraints. However, it is really hard to solve this problem due to complex nonlinear constraints. Thus, it is impossible to use conventional MINLP solvers using derivatives of equations. In this study, the Particle Swarm Optimization (PSO) technique is employed. The ethylene oxide plant is illustrated to verify the efficacy of this study.

  11. Constrained Metric Learning by Permutation Inducing Isometries.

    PubMed

    Bosveld, Joel; Mahmood, Arif; Huynh, Du Q; Noakes, Lyle

    2016-01-01

    The choice of metric critically affects the performance of classification and clustering algorithms. Metric learning algorithms attempt to improve performance, by learning a more appropriate metric. Unfortunately, most of the current algorithms learn a distance function which is not invariant to rigid transformations of images. Therefore, the distances between two images and their rigidly transformed pair may differ, leading to inconsistent classification or clustering results. We propose to constrain the learned metric to be invariant to the geometry preserving transformations of images that induce permutations in the feature space. The constraint that these transformations are isometries of the metric ensures consistent results and improves accuracy. Our second contribution is a dimension reduction technique that is consistent with the isometry constraints. Our third contribution is the formulation of the isometry constrained logistic discriminant metric learning (IC-LDML) algorithm, by incorporating the isometry constraints within the objective function of the LDML algorithm. The proposed algorithm is compared with the existing techniques on the publicly available labeled faces in the wild, viewpoint-invariant pedestrian recognition, and Toy Cars data sets. The IC-LDML algorithm has outperformed existing techniques for the tasks of face recognition, person identification, and object classification by a significant margin.

  12. Homonuclear 1H NMR and circular dichroism study of the HIV-1 Tat Eli variant.

    PubMed

    Watkins, Jennifer D; Campbell, Grant R; Halimi, Hubert; Loret, Erwann P

    2008-09-22

    The HIV-1 Tat protein is a promising target to develop AIDS therapies, particularly vaccines, due to its extracellular role that protects HIV-1-infected cells from the immune system. Tat exists in two different lengths, 86 or 87 residues and 99 or 101 residues, with the long form being predominant in clinical isolates. We report here a structural study of the 99 residue Tat Eli variant using 2D liquid-state NMR, molecular modeling and circular dichroism. Tat Eli was obtained from solid-phase peptide synthesis and the purified protein was proven biologically active in a trans-activation assay. Circular dichroism spectra at different temperatures up to 70 degrees C showed that Tat Eli is not a random coil at 20 degrees C. Homonuclear 1H NMR spectra allowed us to identify 1639 NMR distance constraints out of which 264 were interresidual. Molecular modeling satisfying at least 1474 NMR constraints revealed the same folding for different model structures. The Tat Eli model has a core region composed of a part of the N-terminus including the highly conserved Trp 11. The extra residues in the Tat Eli C-terminus protrude from a groove between the basic region and the cysteine-rich region and are well exposed to the solvent. We show that active Tat variants share a similar folding pattern whatever their size, but mutations induce local structural changes.

  13. Use of 13Cα Chemical-Shifts in Protein Structure Determination

    PubMed Central

    Vila, Jorge A.; Ripoll, Daniel R.; Scheraga, Harold A.

    2008-01-01

    A physics-based method, aimed at determining protein structures by using NOE-derived distances together with observed and computed 13C chemical shifts, is proposed. The approach makes use of 13Cα chemical shifts, computed at the density functional level of theory, to obtain torsional constraints for all backbone and side-chain torsional angles without making a priori use of the occupancy of any region of the Ramachandran map by the amino acid residues. The torsional constraints are not fixed but are changed dynamically in each step of the procedure, following an iterative self-consistent approach intended to identify a set of conformations for which the computed 13Cα chemical shifts match the experimental ones. A test is carried out on a 76-amino acid all-α-helical protein, namely the B. Subtilis acyl carrier protein. It is shown that, starting from randomly generated conformations, the final protein models are more accurate than an existing NMR-derived structure model of this protein, in terms of both the agreement between predicted and observed 13Cα chemical shifts and some stereochemical quality indicators, and of similar accuracy as one of the protein models solved at a high level of resolution. The results provide evidence that this methodology can be used not only for structure determination but also for additional protein structure refinement of NMR-derived models deposited in the Protein Data Bank. PMID:17516673

  14. Spectroscopic analysis of Cepheid variables with 2D radiation-hydrodynamic simulations

    NASA Astrophysics Data System (ADS)

    Vasilyev, Valeriy

    2018-06-01

    The analysis of chemical enrichment history of dwarf galaxies allows to derive constraints on their formation and evolution. In this context, Cepheids play a very important role, as these periodically variable stars provide a means to obtain accurate distances. Besides, chemical composition of Cepheids can provide a strong constraint on the chemical evolution of the system. Standard spectroscopic analysis of Cepheids is based on using one-dimensional (1D) hydrostatic model atmospheres, with convection parametrised using the mixing-length theory. However, this quasi-static approach has theoretically not been validated. In my talk, I will discuss the validity of the quasi-static approximation in spectroscopy of short-periodic Cepheids. I will show the results obtained using a 2D time-dependent envelope model of a pulsating star computed with the radiation-hydrodynamics code CO5BOLD. I will then describe the impact of new models on the spectroscopic diagnostic of the effective temperature, surface gravity, microturbulent velocity, and metallicity. One of the interesting findings of my work is that 1D model atmospheres provide unbiased estimates of stellar parameters and abundances of Cepheid variables for certain phases of their pulsations. Convective inhomogeneities, however, also introduce biases. I will then discuss how these results can be used in a wider parameter space of pulsating stars and present an outlook for the future studies.

  15. FEM Modeling of a Magnetoelectric Transducer for Autonomous Micro Sensors in Medical Application

    NASA Astrophysics Data System (ADS)

    Yang, Gang; Talleb, Hakeim; Gensbittel, Aurélie; Ren, Zhuoxiang

    2015-11-01

    In the context of wireless and autonomous sensors, this paper presents the multiphysics modeling of an energy transducer based on magnetoelectric (ME) composite for biomedical applications. The study considers the power requirement of an implanted sensor, the communication distance, the size limit of the device for minimal invasive insertion as well as the electromagnetic exposure restriction of the human body. To minimize the electromagnetic absorption by the human body, the energy source is provided by an external reader emitting low frequency magnetic field. The modeling is carried out with the finite element method by solving simultaneously the multiple physics problems including the electric load of the conditioning circuit. The simulation results show that with the T-L mode of a trilayer laminated ME composite, the transducer can deliver the required energy in respecting different constraints.

  16. Shape-based diagnosis of the aortic valve

    NASA Astrophysics Data System (ADS)

    Ionasec, Razvan Ioan; Tsymbal, Alexey; Vitanovski, Dime; Georgescu, Bogdan; Zhou, S. Kevin; Navab, Nassir; Comaniciu, Dorin

    2009-02-01

    Disorders of the aortic valve represent a common cardiovascular disease and an important public-health problem worldwide. Pathological valves are currently determined from 2D images through elaborate qualitative evalu- ations and complex measurements, potentially inaccurate and tedious to acquire. This paper presents a novel diagnostic method, which identies diseased valves based on 3D geometrical models constructed from volumetric data. A parametric model, which includes relevant anatomic landmarks as well as the aortic root and lea ets, represents the morphology of the aortic valve. Recently developed robust segmentation methods are applied to estimate the patient specic model parameters from end-diastolic cardiac CT volumes. A discriminative distance function, learned from equivalence constraints in the product space of shape coordinates, determines the corresponding pathology class based on the shape information encoded by the model. Experiments on a heterogeneous set of 63 patients aected by various diseases demonstrated the performance of our method with 94% correctly classied valves.

  17. Higher-order chromatin structure: bridging physics and biology.

    PubMed

    Fudenberg, Geoffrey; Mirny, Leonid A

    2012-04-01

    Advances in microscopy and genomic techniques have provided new insight into spatial chromatin organization inside of the nucleus. In particular, chromosome conformation capture data has highlighted the relevance of polymer physics for high-order chromatin organization. In this context, we review basic polymer states, discuss how an appropriate polymer model can be determined from experimental data, and examine the success and limitations of various polymer models of higher-order interphase chromatin organization. By taking into account topological constraints acting on the chromatin fiber, recently developed polymer models of interphase chromatin can reproduce the observed scaling of distances between genomic loci, chromosomal territories, and probabilities of contacts between loci measured by chromosome conformation capture methods. Polymer models provide a framework for the interpretation of experimental data as ensembles of conformations rather than collections of loops, and will be crucial for untangling functional implications of chromosomal organization. Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. Higher order chromatin structure: bridging physics and biology

    PubMed Central

    Fudenberg, Geoffrey; Mirny, Leonid A.

    2012-01-01

    Recent advances in microscopy and genomic techniques have provided new insight into spatial chromatin organization inside of the nucleus. In particular, chromosome conformation capture data has highlighted the relevance of polymer physics for high-order chromatin organization. In this context, we review basic polymer states, discuss how an appropriate polymer model can be determined from experimental data, and examine the success and limitations of various polymer models of high-order interphase chromatin organization. By taking into account topological constraints acting on the chromatin fiber, recently-developed polymer models of interphase chromatin can reproduce the observed scaling of distances between genomic loci, chromosomal territories, and probabilities of contacts between loci measured by chromosome conformation capture methods. Polymer models provide a framework for the interpretation of experimental data as ensembles of conformations rather than collections of loops, and will be crucial for untangling functional implications of chromosomal organization. PMID:22360992

  19. Constraints on the unified dark energy dark matter model from latest observational data

    NASA Astrophysics Data System (ADS)

    Wu, Puxun; Yu, Hongwei

    2007-03-01

    The generalized Chaplygin gas (GCG) is studied in this paper by using the latest observational data including 182 gold sample type Ia supernovae (Sne Ia) data, the ESSENCE Sne Ia data, the distance ratio from z = 0.35 to 1089 (the redshift of decoupling), the cosmic microwave background shift parameter and the Hubble parameter data. Our results rule out the standard Chaplygin gas model (α = 1) at the 99.7% confidence level, but allow for the λCDM model (α = 0) at the 68.3% confidence level. At a 95.4% confidence level, we obtain w = -0.74-0.09+0.10 and α = -0.14-0.19+0.30. In addition, we find that the phase transition from deceleration to acceleration occurs at redshift zq = 0~0.78-0.89 at a 1σ confidence level for the GCG model.

  20. Constraints on T-Odd, P-Even Interactions from Electric Dipole Moments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    A. Kurylov; G. C. McLaughlin; M.J. Ramsey-Musolf

    2001-03-01

    We construct the relationship between nonrenormalizable,effective, time-reversal violating (TV) parity-conserving (PC) interactions of quarks and gauge bosons and various low-energy TVPC and TV parity-violating (PV) observables. Using effective field theory methods, we delineate the scenarios under which experimental limits on permanent electric dipole moments (EDM's) of the electron, neutron, and neutral atoms as well as limits on TVPC observables provide the most stringent bounds on new TVPC interactions. Under scenarios in which parity invariance is restored at short distances, the one-loop EDM of elementary fermions generate the most severe constraints. The limits derived from the atomic EDM of {sup 199}Hgmore » are considerably weaker. When parity symmetry remains broken at short distances, direct TVPC search limits provide the least ambiguous bounds. The direct limits follow from TVPC interactions between two quarks.« less

  1. Searching gamma-ray bursts for gravitational lensing echoes - Implications for compact dark matter

    NASA Technical Reports Server (NTRS)

    Nemiroff, R. J.; Norris, J. P.; Wickramasinghe, W. A. D. T.; Horack, J. M.; Kouveliotou, C.; Fishman, G. J.; Meegan, C. A.; Wilson, R. B.; Paciesas, W. S.

    1993-01-01

    The first available 44 gamma-ray bursts (GRBs) detected by the Burst and Transient Source Experiment on board the Compton Gamma-Ray Observatory have been inspected for echo signals following shortly after the main signal. No significant echoes have been found. Echoes would have been expected were the GRBs distant enough and the universe populated with a sufficient density of compact objects composing the dark matter. Constraints on dark matter abundance and GRB redshifts from the present data are presented and discussed. Based on these preliminary results, a universe filled to critical density of compact objects between 10 exp 6.5 and 10 exp 8.1 solar masses are now marginally excluded, or the most likely cosmological distance paradigm for GRBs is not correct. We expect future constraints to be able either to test currently popular cosmological dark matter paradigms or to indicate that GRBs do not lie at cosmological distances.

  2. Automatic Constraint Detection for 2D Layout Regularization.

    PubMed

    Jiang, Haiyong; Nan, Liangliang; Yan, Dong-Ming; Dong, Weiming; Zhang, Xiaopeng; Wonka, Peter

    2016-08-01

    In this paper, we address the problem of constraint detection for layout regularization. The layout we consider is a set of two-dimensional elements where each element is represented by its bounding box. Layout regularization is important in digitizing plans or images, such as floor plans and facade images, and in the improvement of user-created contents, such as architectural drawings and slide layouts. To regularize a layout, we aim to improve the input by detecting and subsequently enforcing alignment, size, and distance constraints between layout elements. Similar to previous work, we formulate layout regularization as a quadratic programming problem. In addition, we propose a novel optimization algorithm that automatically detects constraints. We evaluate the proposed framework using a variety of input layouts from different applications. Our results demonstrate that our method has superior performance to the state of the art.

  3. Distance-constrained orthogonal Latin squares for brain-computer interface.

    PubMed

    Luo, Gang; Min, Wanli

    2012-02-01

    The P300 brain-computer interface (BCI) using electroencephalogram (EEG) signals can allow amyotrophic lateral sclerosis (ALS) patients to instruct computers to perform tasks. To strengthen the P300 response and increase classification accuracy, we proposed an experimental design where characters are intensified according to orthogonal Latin square pairs. These orthogonal Latin square pairs satisfy certain distance constraint so that neighboring characters are not intensified simultaneously. However, it is unknown whether such distance-constrained, orthogonal Latin square pairs actually exist. In this paper, we show that for every matrix size commonly used in P300 BCI, thousands to millions of such distance-constrained, orthogonal Latin square pairs can be systematically and efficiently constructed and are sufficient for the purpose of being used in P300 BCI.

  4. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Daniel, Scott F.; Linder, Eric V.; Lawrence Berkeley National Laboratory, Berkeley, California

    Deviations from general relativity, such as could be responsible for the cosmic acceleration, would influence the growth of large-scale structure and the deflection of light by that structure. We clarify the relations between several different model-independent approaches to deviations from general relativity appearing in the literature, devising a translation table. We examine current constraints on such deviations, using weak gravitational lensing data of the CFHTLS and COSMOS surveys, cosmic microwave background radiation data of WMAP5, and supernova distance data of Union2. A Markov chain Monte Carlo likelihood analysis of the parameters over various redshift ranges yields consistency with general relativitymore » at the 95% confidence level.« less

  5. Chemical composition of Earth, Venus, and Mercury.

    PubMed

    Morgan, J W; Anders, E

    1980-12-01

    Model compositions of Earth, Venus, and Mercury are calculated from the premise that planets and chondrites underwent four identical fractionation processes in the solar nebula. Because elements of similar properties stay together in these processes, five constraints suffice to define the composition of a planet: mass of the core, abundance of U, and the ratios K/U, Tl/U, and FeO/(FeO + MgO). Complete abundance tables, and normative mineralogies, are given for all three planets. Review of available data shows only a few gross trends for the inner planets: FeO decreases with heliocentric distance, whereas volatiles are depleted and refractories are enriched in the smaller planets.

  6. An approach to automated particle picking from electron micrographs based on reduced representation templates.

    PubMed

    Volkmann, Niels

    2004-01-01

    Reduced representation templates are used in a real-space pattern matching framework to facilitate automatic particle picking from electron micrographs. The procedure consists of five parts. First, reduced templates are constructed either from models or directly from the data. Second, a real-space pattern matching algorithm is applied using the reduced representations as templates. Third, peaks are selected from the resulting score map using peak-shape characteristics. Fourth, the surviving peaks are tested for distance constraints. Fifth, a correlation-based outlier screening is applied. Test applications to a data set of keyhole limpet hemocyanin particles indicate that the method is robust and reliable.

  7. Preliminary ground motion prediction equations for the Central and Eastern United States

    NASA Astrophysics Data System (ADS)

    Graizer, V.

    2014-12-01

    At the current stage I used the database created under the Next Generation Attenuations (NGA-East) project by Cramer et al. (2013). In contrast to the active tectonic environment in the Western US (WUS) the strong motion record database for the stable continental environment in the Central and Eastern US (CEUS) is not sufficient to create purely empirical ground motion prediction equations (GMPE) covering required for the PSHA magnitude (4.5

  8. Constraint-based Temporal Reasoning with Preferences

    NASA Technical Reports Server (NTRS)

    Khatib, Lina; Morris, Paul; Morris, Robert; Rossi, Francesca; Sperduti, Alessandro; Venable, K. Brent

    2005-01-01

    Often we need to work in scenarios where events happen over time and preferences are associated to event distances and durations. Soft temporal constraints allow one to describe in a natural way problems arising in such scenarios. In general, solving soft temporal problems require exponential time in the worst case, but there are interesting subclasses of problems which are polynomially solvable. In this paper we identify one of such subclasses giving tractability results. Moreover, we describe two solvers for this class of soft temporal problems, and we show some experimental results. The random generator used to build the problems on which tests are performed is also described. We also compare the two solvers highlighting the tradeoff between performance and robustness. Sometimes, however, temporal local preferences are difficult to set, and it may be easier instead to associate preferences to some complete solutions of the problem. To model everything in a uniform way via local preferences only, and also to take advantage of the existing constraint solvers which exploit only local preferences, we show that machine learning techniques can be useful in this respect. In particular, we present a learning module based on a gradient descent technique which induces local temporal preferences from global ones. We also show the behavior of the learning module on randomly-generated examples.

  9. Solid-state NMR detection of 14N-13C dipolar couplings between amino acid side groups provides constraints on amyloid fibril architecture.

    PubMed

    Middleton, David A

    2011-02-01

    Solid-state nuclear magnetic resonance (SSNMR) is a powerful technique for the structural analysis of amyloid fibrils. With suitable isotope labelling patterns, SSNMR can provide constraints on the secondary structure, alignment and registration of β-strands within amyloid fibrils and identify the tertiary and quaternary contacts defining the packing of the β-sheet layers. Detection of (14)N-(13)C dipolar couplings may provide potentially useful additional structural constraints on β-sheet packing within amyloid fibrils but has not until now been exploited for this purpose. Here a frequency-selective, transfer of population in double resonance SSNMR experiment is used to detect a weak (14)N-(13)C dipolar coupling in amyloid-like fibrils of the peptide H(2)N-SNNFGAILSS-COOH, which was uniformly (13)C and (15)N labelled across the four C-terminal amino acids. The (14)N-(13)C interatomic distance between leucine and asparagine side groups is constrained between 2.4 and 3.8 Å, which allows current structural models of the β-spine arrangement within the fibrils to be refined. This procedure could be useful for the general structural analysis of other proteins in condensed phases and environments, such as biological membranes. Copyright © 2011 John Wiley & Sons, Ltd.

  10. Ring-like reliable PON planning with physical constraints for a smart grid

    NASA Astrophysics Data System (ADS)

    Wang, Xin; Gu, Rentao; Ji, Yuefeng

    2016-01-01

    Due to the high reliability requirements in the communication networks of a smart grid, a ring-like reliable PON is an ideal choice to carry power distribution information. Economical network planning is also very important for the smart grid communication infrastructure. Although the ring-like reliable PON has been widely used in the real applications, as far as we know, little research has been done on the network optimization subject of the ring-like reliable PON. Most PON planning research studies only consider a star-like topology or cascaded PON network, which barely guarantees the reliability requirements of the smart grid. In this paper, we mainly investigate the economical network planning problem for the ring-like reliable PON of the smart grid. To address this issue, we built a mathematical model for the planning problem of the ring-like reliable PON, and the objective was to minimize the total deployment costs under physical constraints. The model is simplified such that all of the nodes have the same properties, except OLT, because each potential splitter site can be located in the same ONU position in power communication networks. The simplified model is used to construct an optimal main tree topology in the complete graph and a backup-protected tree topology in the residual graph. An efficient heuristic algorithm, called the Constraints and Minimal Weight Oriented Fast Searching Algorithm (CMW-FSA), is proposed. In CMW-FSA, a feasible solution can be obtained directly with oriented constraints and a few recursive search processes. From the simulation results, the proposed planning model and CMW-FSA are verified to be accurate (the error rates are less than 0.4%) and effective compared with the accurate solution (CAESA), especially in small and sparse scenarios. The CMW-FSA significantly reduces the computation time compared with the CAESA. The time complexity algorithm of the CMW-FSA is acceptable and calculated as T(n) = O(n3). After evaluating the effects of the parameters of the two PON systems, the total planning costs of each scenario show a general declining trend and reach a threshold as the respective maximal transmission distances and maximal time delays increase.

  11. The use of anaphoric pronouns by French children in narrative: evidence from constrained text production.

    PubMed

    Millogo, Victor Emmanuel

    2005-05-01

    This paper describes the acquisition of the 3rd person pronoun 'il/elle' (he, she, it) in seven to twelve-year-old French children (N = 58), in written production. An experiment was conducted to examine the relationship between the use of this anaphoric pronoun and the accessibility of the memory-trace of the corresponding referent in the texts. Referential accessibility in short texts was varied according to three factors: referential distance, thematization of the agent role (first sentence subject), and discourse focus. We found that the children were sensitive to the distance factor as early as 7;0, i.e. they used fewer personal pronouns when the referential distance increased. However, children of different ages differed in their weighting of the discourse focus factor and the thematization factor: the seven-year-olds (N = 18) and the eleven-year-olds (N = 20) were sensitive to variation of the discourse focus but not the thematization factor, while for the nine-year-olds (N = 20) it was the reverse. The main results suggest: (a) when seven and nine-year-olds use the pronoun 'il/elle', they do not comply with the constraints associated with the accessibility of the memory-trace of the referent; (b) memory constraints have an effect from the age of 7;0, but only when the discourse focus is maintained. It was concluded that the discourse management of the French personal pronoun 'il/elle' is not totally mastered at 11;0: children cannot operationally integrate the whole array of constraints implied in anaphoric management.

  12. Universal predictability of mobility patterns in cities

    PubMed Central

    Yan, Xiao-Yong; Zhao, Chen; Fan, Ying; Di, Zengru; Wang, Wen-Xu

    2014-01-01

    Despite the long history of modelling human mobility, we continue to lack a highly accurate approach with low data requirements for predicting mobility patterns in cities. Here, we present a population-weighted opportunities model without any adjustable parameters to capture the underlying driving force accounting for human mobility patterns at the city scale. We use various mobility data collected from a number of cities with different characteristics to demonstrate the predictive power of our model. We find that insofar as the spatial distribution of population is available, our model offers universal prediction of mobility patterns in good agreement with real observations, including distance distribution, destination travel constraints and flux. By contrast, the models that succeed in modelling mobility patterns in countries are not applicable in cities, which suggests that there is a diversity of human mobility at different spatial scales. Our model has potential applications in many fields relevant to mobility behaviour in cities, without relying on previous mobility measurements. PMID:25232053

  13. The Structures and Possible Sources of Preservice Elementary Teachers' Mental Models About Moon Phases

    NASA Astrophysics Data System (ADS)

    Oh, Jun-Young; Kang, Yong-Hee; Yoo, Kye-Hwa

    2005-09-01

    This study was to understand the components that influence preservice elementary teachers' mental models about `astronomical phenomena' such as the Seasons of the year, and the Lunar Phases of the month. We selected university of education students among whom 23 were in the second year. The data collected from the paper-pencil test and individual interview with students. The results of this study show that the students had apparent synthetic Mental models, and that the 'distance theory, and occultation theory' had most important effects on their Mental Models. It can be said that preservice elementary teachers' initial mental models of the `astronomical phenomenon' have their origin in their belief sets (specific theory) related to `astronomical phenomenon', on the basis of which they can interpret their observations and cultural information with the constraints of a naive framework of physics. The structures and possible sources of their mental models for overcoming these synthetic mental models were also discussed.

  14. De novo establishment of wild-type song culture in the zebra finch.

    PubMed

    Fehér, Olga; Wang, Haibin; Saar, Sigal; Mitra, Partha P; Tchernichovski, Ofer

    2009-05-28

    Culture is typically viewed as consisting of traits inherited epigenetically, through social learning. However, cultural diversity has species-typical constraints, presumably of genetic origin. A celebrated, if contentious, example is whether a universal grammar constrains syntactic diversity in human languages. Oscine songbirds exhibit song learning and provide biologically tractable models of culture: members of a species show individual variation in song and geographically separated groups have local song dialects. Different species exhibit distinct song cultures, suggestive of genetic constraints. Without such constraints, innovations and copying errors should cause unbounded variation over multiple generations or geographical distance, contrary to observations. Here we report an experiment designed to determine whether wild-type song culture might emerge over multiple generations in an isolated colony founded by isolates, and, if so, how this might happen and what type of social environment is required. Zebra finch isolates, unexposed to singing males during development, produce song with characteristics that differ from the wild-type song found in laboratory or natural colonies. In tutoring lineages starting from isolate founders, we quantified alterations in song across tutoring generations in two social environments: tutor-pupil pairs in sound-isolated chambers and an isolated semi-natural colony. In both settings, juveniles imitated the isolate tutors but changed certain characteristics of the songs. These alterations accumulated over learning generations. Consequently, songs evolved towards the wild-type in three to four generations. Thus, species-typical song culture can appear de novo. Our study has parallels with language change and evolution. In analogy to models in quantitative genetics, we model song culture as a multigenerational phenotype partly encoded genetically in an isolate founding population, influenced by environmental variables and taking multiple generations to emerge.

  15. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: measuring H(z) and DA(z) at z = 0.57 with clustering wedges

    NASA Astrophysics Data System (ADS)

    Kazin, Eyal A.; Sánchez, Ariel G.; Cuesta, Antonio J.; Beutler, Florian; Chuang, Chia-Hsun; Eisenstein, Daniel J.; Manera, Marc; Padmanabhan, Nikhil; Percival, Will J.; Prada, Francisco; Ross, Ashley J.; Seo, Hee-Jong; Tinker, Jeremy; Tojeiro, Rita; Xu, Xiaoying; Brinkmann, J.; Joel, Brownstein; Nichol, Robert C.; Schlegel, David J.; Schneider, Donald P.; Thomas, Daniel

    2013-10-01

    We analyse the 2D correlation function of the Sloan Digital Sky Survey-III Baryon Oscillation Spectroscopic Survey (BOSS) CMASS sample of massive galaxies of the ninth data release to measure cosmic expansion H and the angular diameter distance DA at a mean redshift of = 0.57. We apply, for the first time, a new correlation function technique called clustering wedges ξΔμ(s). Using a physically motivated model, the anisotropic baryonic acoustic feature in the galaxy sample is detected at a significance level of 4.7σ compared to a featureless model. The baryonic acoustic feature is used to obtain model-independent constraints cz/H/rs = 12.28 ± 0.82 (6.7 percent accuracy) and DA/rs = 9.05 ± 0.27 (3.0 per cent) with a correlation coefficient of -0.5, where rs is the sound horizon scale at the end of the baryonic drag era. We conduct thorough tests on the data and 600 simulated realizations, finding robustness of the results regardless of the details of the analysis method. Combining this with rs constraints from the cosmic microwave background, we obtain H(0.57) = 90.8 ± 6.2 km s-1 Mpc-1 and DA(0.57) = 1386 ± 45 Mpc. We use simulations to forecast results of the final BOSS CMASS data set. We apply the reconstruction technique on the simulations demonstrating that the sharpening of the anisotropic baryonic acoustic feature should improve the detection as well as tighten constraints of H and DA by ˜30 per cent on average.

  16. First X-ray Statistical Tests for Clumpy Torii Models: Constraints from RXTE monitoring of Seyfert AGN

    NASA Astrophysics Data System (ADS)

    Markowitz, A.

    2015-09-01

    We summarize two papers providing the first X-ray-derived statistical constraints for both clumpy-torus model parameters and cloud ensemble properties. In Markowitz, Krumpe, & Nikutta (2014), we explored multi-timescale variability in line-of-sight X-ray absorbing gas as a function of optical classification. We examined 55 Seyferts monitored with the Rossi X-ray Timing Explorer, and found in 8 objects a total of 12 eclipses, with durations between hours and years. Most clouds are commensurate with the outer portions of the BLR, or the inner regions of infrared-emitting dusty tori. The detection of eclipses in type Is disfavors sharp-edged tori. We provide probabilities to observe a source undergoing an absorption event for both type Is and IIs, yielding constraints in [N_0, sigma, i] parameter space. In Nikutta et al., in prep., we infer that the small cloud angular sizes, as seen from the SMBH, imply the presence of >10^7 clouds in BLR+torus to explain observed covering factors. Cloud size is roughly proportional to distance from the SMBH, hinting at the formation processes (e.g. disk fragmentation). All observed clouds are sub-critical with respect to tidal disruption; self-gravity alone cannot contain them. External forces (e.g. magnetic fields, ambient pressure) are needed to contain them, or otherwise the clouds must be short-lived. Finally, we infer that the radial cloud density distribution behaves as 1/r^{0.7}, compatible with VLTI observations. Our results span both dusty and non-dusty clumpy media, and probe model parameter space complementary to that for short-term eclipses observed with XMM-Newton, Suzaku, and Chandra.

  17. A Random Walk Approach to Query Informative Constraints for Clustering.

    PubMed

    Abin, Ahmad Ali

    2017-08-09

    This paper presents a random walk approach to the problem of querying informative constraints for clustering. The proposed method is based on the properties of the commute time, that is the expected time taken for a random walk to travel between two nodes and return, on the adjacency graph of data. Commute time has the nice property of that, the more short paths connect two given nodes in a graph, the more similar those nodes are. Since computing the commute time takes the Laplacian eigenspectrum into account, we use this property in a recursive fashion to query informative constraints for clustering. At each recursion, the proposed method constructs the adjacency graph of data and utilizes the spectral properties of the commute time matrix to bipartition the adjacency graph. Thereafter, the proposed method benefits from the commute times distance on graph to query informative constraints between partitions. This process iterates for each partition until the stop condition becomes true. Experiments on real-world data show the efficiency of the proposed method for constraints selection.

  18. The Planner in the Vortex of a Developing Storm

    ERIC Educational Resources Information Center

    Humphreys, Edward H.

    1975-01-01

    Discusses three essential differences between playing the planning game at the national and at the local level. These involve financial constraints, a concern for manpower development, and the distance between the planner and the public. (Author/WM)

  19. Unifying mechanical and thermodynamic descriptions across the thioredoxin protein family.

    PubMed

    Mottonen, James M; Xu, Minli; Jacobs, Donald J; Livesay, Dennis R

    2009-05-15

    We compare various predicted mechanical and thermodynamic properties of nine oxidized thioredoxins (TRX) using a Distance Constraint Model (DCM). The DCM is based on a nonadditive free energy decomposition scheme, where entropic contributions are determined from rigidity and flexibility of structure based on distance constraints. We perform averages over an ensemble of constraint topologies to calculate several thermodynamic and mechanical response functions that together yield quantitative stability/flexibility relationships (QSFR). Applied to the TRX protein family, QSFR metrics display a rich variety of similarities and differences. In particular, backbone flexibility is well conserved across the family, whereas cooperativity correlation describing mechanical and thermodynamic couplings between the residue pairs exhibit distinctive features that readily standout. The diversity in predicted QSFR metrics that describe cooperativity correlation between pairs of residues is largely explained by a global flexibility order parameter describing the amount of intrinsic flexibility within the protein. A free energy landscape is calculated as a function of the flexibility order parameter, and key values are determined where the native-state, transition-state, and unfolded-state are located. Another key value identifies a mechanical transition where the global nature of the protein changes from flexible to rigid. The key values of the flexibility order parameter help characterize how mechanical and thermodynamic response is linked. Variation in QSFR metrics and key characteristics of global flexibility are related to the native state X-ray crystal structure primarily through the hydrogen bond network. Furthermore, comparison of three TRX redox pairs reveals differences in thermodynamic response (i.e., relative melting point) and mechanical properties (i.e., backbone flexibility and cooperativity correlation) that are consistent with experimental data on thermal stabilities and NMR dynamical profiles. The results taken together demonstrate that small-scale structural variations are amplified into discernible global differences by propagating mechanical couplings through the H-bond network.

  20. The Spin of the Black Hole GS 1124-683: Observation of a Retrograde Accretion Disk?

    NASA Astrophysics Data System (ADS)

    Morningstar, Warren R.; Miller, Jon M.; Reis, Rubens C.; Ebisawa, Ken

    2014-04-01

    We re-examine archival Ginga data for the black hole binary system GS 1124-683, obtained when the system was undergoing its 1991 outburst. Our analysis estimates the dimensionless spin parameter a * = cJ/GM2 by fitting the X-ray continuum spectra obtained while the system was in the "thermal dominant" state. For likely values of mass and distance, we find the spin to be a_{*}=-0.25_{-0.64}^{+0.05} (90% confidence), implying that the disk is retrograde (i.e., rotating antiparallel to the spin axis of the black hole). We note that this measurement would be better constrained if the distance to the binary and the mass of the black hole were more accurately determined. This result is unaffected by the model used to fit the hard component of the spectrum. In order to be able to recover a prograde spin, the mass of the black hole would need to be at least 15.25 M ⊙, or the distance would need to be less than 4.5 kpc, both of which disagree with previous determinations of the black hole mass and distance. If we allow f col to be free, we obtain no useful spin constraint. We discuss our results in the context of recent spin measurements and implications for jet production.

  1. Characteristic angles in the wetting of an angular region: deposit growth.

    PubMed

    Popov, Yuri O; Witten, Thomas A

    2003-09-01

    Solids dispersed in a drying drop migrate to the (pinned) contact line. This migration is caused by outward flows driven by the loss of the solvent due to evaporation and by geometrical constraint that the drop maintains an equilibrium surface shape with a fixed boundary. Here, in continuation of our earlier paper, we theoretically investigate the evaporation rate, the flow field, and the rate of growth of the deposit patterns in a drop over an angular sector on a plane substrate. Asymptotic power laws near the vertex (as distance to the vertex goes to zero) are obtained. A hydrodynamic model of fluid flow near the singularity of the vertex is developed and the velocity field is obtained. The rate of the deposit growth near the contact line is found in two time regimes. The deposited mass falls off as a weak power gamma of distance close to the vertex and as a stronger power beta of distance further from the vertex. The power gamma depends only slightly on the opening angle alpha and stays roughly between -1/3 and 0. The power beta varies from -1 to 0 as the opening angle increases from 0 degrees to 180 degrees. At a given distance from the vertex, the deposited mass grows faster and faster with time, with the greatest increase in the growth rate occurring at the early stages of the drying process.

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Morningstar, Warren R.; Miller, Jon M.; Reis, Rubens C.

    We re-examine archival Ginga data for the black hole binary system GS 1124–683, obtained when the system was undergoing its 1991 outburst. Our analysis estimates the dimensionless spin parameter a {sub *} = cJ/GM{sup 2} by fitting the X-ray continuum spectra obtained while the system was in the ''thermal dominant'' state. For likely values of mass and distance, we find the spin to be a{sub ∗}=−0.25{sub −0.64}{sup +0.05} (90% confidence), implying that the disk is retrograde (i.e., rotating antiparallel to the spin axis of the black hole). We note that this measurement would be better constrained if the distance tomore » the binary and the mass of the black hole were more accurately determined. This result is unaffected by the model used to fit the hard component of the spectrum. In order to be able to recover a prograde spin, the mass of the black hole would need to be at least 15.25 M {sub ☉}, or the distance would need to be less than 4.5 kpc, both of which disagree with previous determinations of the black hole mass and distance. If we allow f {sub col} to be free, we obtain no useful spin constraint. We discuss our results in the context of recent spin measurements and implications for jet production.« less

  3. Using Game Theoretic Models to Predict Pilot Behavior in NextGen Merging and Landing Scenario

    NASA Technical Reports Server (NTRS)

    Yildiz, Yildiray; Lee, Ritchie; Brat, Guillaume

    2012-01-01

    In this paper, we present an implementation of the Semi Network-Form Game framework to predict pilot behavior in a merging and landing scenario. In this scenario, two aircraft are approaching to a freeze horizon with approximately equal distance when they become aware of each other via an ADS-B communication link that will be available in NextGen airspace. Both pilots want to gain advantage over the other by entering the freeze horizon earlier and obtain the first place in landing. They re-adjust their speed accordingly. However, they cannot simply increase their speed to the maximum allowable values since they are concerned with safety, separation distance, effort, possibility of being vectored-off from landing and possibility of violating speed constraints. We present how to model these concerns and the rest of the system using semi network-from game framework. Using this framework, based on certain assumptions on pilot utility functions and on system configuration, we provide estimates of pilot behavior and overall system evolution in time. We also discuss the possible employment of this modeling tool for airspace design optimization. To support this discussion, we provide a case where we investigate the effect of increasing the merging point speed limit on the commanded speed distribution and on the percentage of vectored aircraft.

  4. Particle Dark Matter constraints: the effect of Galactic uncertainties

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Benito, Maria; Bernal, Nicolás; Iocco, Fabio

    2017-02-01

    Collider, space, and Earth based experiments are now able to probe several extensions of the Standard Model of particle physics which provide viable dark matter candidates. Direct and indirect dark matter searches rely on inputs of astrophysical nature, such as the local dark matter density or the shape of the dark matter density profile in the target in object. The determination of these quantities is highly affected by astrophysical uncertainties. The latter, especially those for our own Galaxy, are ill-known, and often not fully accounted for when analyzing the phenomenology of particle physics models. In this paper we present amore » systematic, quantitative estimate of how astrophysical uncertainties on Galactic quantities (such as the local galactocentric distance, circular velocity, or the morphology of the stellar disk and bulge) propagate to the determination of the phenomenology of particle physics models, thus eventually affecting the determination of new physics parameters. We present results in the context of two specific extensions of the Standard Model (the Singlet Scalar and the Inert Doublet) that we adopt as case studies for their simplicity in illustrating the magnitude and impact of such uncertainties on the parameter space of the particle physics model itself. Our findings point toward very relevant effects of current Galactic uncertainties on the determination of particle physics parameters, and urge a systematic estimate of such uncertainties in more complex scenarios, in order to achieve constraints on the determination of new physics that realistically include all known uncertainties.« less

  5. Test of the cosmic evolution using Gaussian processes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Ming-Jian; Xia, Jun-Qing, E-mail: zhangmj@ihep.ac.cn, E-mail: xiajq@bnu.edu.cn

    2016-12-01

    Much focus was on the possible slowing down of cosmic acceleration under the dark energy parametrization. In the present paper, we investigate this subject using the Gaussian processes (GP), without resorting to a particular template of dark energy. The reconstruction is carried out by abundant data including luminosity distance from Union2, Union2.1 compilation and gamma-ray burst, and dynamical Hubble parameter. It suggests that slowing down of cosmic acceleration cannot be presented within 95% C.L., in considering the influence of spatial curvature and Hubble constant. In order to reveal the reason of tension between our reconstruction and previous parametrization constraint formore » Union2 data, we compare them and find that slowing down of acceleration in some parametrization is only a ''mirage'. Although these parameterizations fits well with the observational data, their tension can be revealed by high order derivative of distance D. Instead, GP method is able to faithfully model the cosmic expansion history.« less

  6. Double-Cascade Events from New Physics in Icecube [Double Bangs from New Physics in IceCube

    DOE PAGES

    Coloma, Pilar; Machado, Pedro A. N.; Martinez-Soler, Ivan; ...

    2017-11-16

    A variety of new physics models allows for neutrinos to up-scatter into heavier states. If the incident neutrino is energetic enough, the heavy neutrino may travel some distance before decaying. In this work, we consider the atmospheric neutrino flux as a source of such events. At IceCube, this would lead to a “double-bang” (DB) event topology, similar to what is predicted to occur for tau neutrinos at ultrahigh energies. The DB event topology has an extremely low background rate from coincident atmospheric cascades, making this a distinctive signature of new physics. Finally, our results indicate that IceCube should already bemore » able to derive new competitive constraints on models with GeV-scale sterile neutrinos using existing data.« less

  7. Double-Cascade Events from New Physics in Icecube [Double Bangs from New Physics in IceCube

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Coloma, Pilar; Machado, Pedro A. N.; Martinez-Soler, Ivan

    A variety of new physics models allows for neutrinos to up-scatter into heavier states. If the incident neutrino is energetic enough, the heavy neutrino may travel some distance before decaying. In this work, we consider the atmospheric neutrino flux as a source of such events. At IceCube, this would lead to a “double-bang” (DB) event topology, similar to what is predicted to occur for tau neutrinos at ultrahigh energies. The DB event topology has an extremely low background rate from coincident atmospheric cascades, making this a distinctive signature of new physics. Finally, our results indicate that IceCube should already bemore » able to derive new competitive constraints on models with GeV-scale sterile neutrinos using existing data.« less

  8. Longer guts and higher food quality increase energy intake in migratory swans.

    PubMed

    van Gils, Jan A; Beekman, Jan H; Coehoorn, Pieter; Corporaal, Els; Dekkers, Ten; Klaassen, Marcel; van Kraaij, Rik; de Leeuw, Rinze; de Vries, Peter P

    2008-11-01

    1. Within the broad field of optimal foraging, it is increasingly acknowledged that animals often face digestive constraints rather than constraints on rates of food collection. This therefore calls for a formalization of how animals could optimize food absorption rates. 2. Here we generate predictions from a simple graphical optimal digestion model for foragers that aim to maximize their (true) metabolizable food intake over total time (i.e. including nonforaging bouts) under a digestive constraint. 3. The model predicts that such foragers should maintain a constant food retention time, even if gut length or food quality changes. For phenotypically flexible foragers, which are able to change the size of their digestive machinery, this means that an increase in gut length should go hand in hand with an increase in gross intake rate. It also means that better quality food should be digested more efficiently. 4. These latter two predictions are tested in a large avian long-distance migrant, the Bewick's swan (Cygnus columbianus bewickii), feeding on grasslands in its Dutch wintering quarters. 5. Throughout winter, free-ranging Bewick's swans, growing a longer gut and experiencing improved food quality, increased their gross intake rate (i.e. bite rate) and showed a higher digestive efficiency. These responses were in accordance with the model and suggest maintenance of a constant food retention time. 6. These changes doubled the birds' absorption rate. Had only food quality changed (and not gut length), then absorption rate would have increased by only 67%; absorption rate would have increased by only 17% had only gut length changed (and not food quality). 7. The prediction that gross intake rate should go up with gut length parallels the mechanism included in some proximate models of foraging that feeding motivation scales inversely to gut fullness. We plea for a tighter integration between ultimate and proximate foraging models.

  9. Geometric Integration of Hybrid Correspondences for RGB-D Unidirectional Tracking

    PubMed Central

    Tang, Shengjun; Chen, Wu; Wang, Weixi; Li, Xiaoming; Li, Wenbin; Huang, Zhengdong; Hu, Han; Guo, Renzhong

    2018-01-01

    Traditionally, visual-based RGB-D SLAM systems only use correspondences with valid depth values for camera tracking, thus ignoring the regions without 3D information. Due to the strict limitation on measurement distance and view angle, such systems adopt only short-range constraints which may introduce larger drift errors during long-distance unidirectional tracking. In this paper, we propose a novel geometric integration method that makes use of both 2D and 3D correspondences for RGB-D tracking. Our method handles the problem by exploring visual features both when depth information is available and when it is unknown. The system comprises two parts: coarse pose tracking with 3D correspondences, and geometric integration with hybrid correspondences. First, the coarse pose tracking generates the initial camera pose using 3D correspondences with frame-by-frame registration. The initial camera poses are then used as inputs for the geometric integration model, along with 3D correspondences, 2D-3D correspondences and 2D correspondences identified from frame pairs. The initial 3D location of the correspondence is determined in two ways, from depth image and by using the initial poses to triangulate. The model improves the camera poses and decreases drift error during long-distance RGB-D tracking iteratively. Experiments were conducted using data sequences collected by commercial Structure Sensors. The results verify that the geometric integration of hybrid correspondences effectively decreases the drift error and improves mapping accuracy. Furthermore, the model enables a comparative and synergistic use of datasets, including both 2D and 3D features. PMID:29723974

  10. Geometric Integration of Hybrid Correspondences for RGB-D Unidirectional Tracking.

    PubMed

    Tang, Shengjun; Chen, Wu; Wang, Weixi; Li, Xiaoming; Darwish, Walid; Li, Wenbin; Huang, Zhengdong; Hu, Han; Guo, Renzhong

    2018-05-01

    Traditionally, visual-based RGB-D SLAM systems only use correspondences with valid depth values for camera tracking, thus ignoring the regions without 3D information. Due to the strict limitation on measurement distance and view angle, such systems adopt only short-range constraints which may introduce larger drift errors during long-distance unidirectional tracking. In this paper, we propose a novel geometric integration method that makes use of both 2D and 3D correspondences for RGB-D tracking. Our method handles the problem by exploring visual features both when depth information is available and when it is unknown. The system comprises two parts: coarse pose tracking with 3D correspondences, and geometric integration with hybrid correspondences. First, the coarse pose tracking generates the initial camera pose using 3D correspondences with frame-by-frame registration. The initial camera poses are then used as inputs for the geometric integration model, along with 3D correspondences, 2D-3D correspondences and 2D correspondences identified from frame pairs. The initial 3D location of the correspondence is determined in two ways, from depth image and by using the initial poses to triangulate. The model improves the camera poses and decreases drift error during long-distance RGB-D tracking iteratively. Experiments were conducted using data sequences collected by commercial Structure Sensors. The results verify that the geometric integration of hybrid correspondences effectively decreases the drift error and improves mapping accuracy. Furthermore, the model enables a comparative and synergistic use of datasets, including both 2D and 3D features.

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zamfir, Michael; Cumming, Andrew; Galloway, Duncan K., E-mail: mzamfir@physics.mcgill.ca, E-mail: cumming@physics.mcgill.ca, E-mail: Duncan.Galloway@monash.edu

    We investigate the constraints on neutron star mass and radius in GS 1826-24 from models of light curves and spectral evolution of type I X-ray bursts. This source shows remarkable agreement with theoretical calculations of burst energies, recurrence times, and light curves. We first exploit this agreement to set the overall luminosity scale of the observed bursts. When combined with a measured blackbody normalization, this leads to a distance- and anisotropy-independent measurement of the ratio between the redshift 1 + z and color-correction factor f{sub c}. We find 1 + z = 1.19-1.28 for f{sub c} = 1.4-1.5. We thenmore » compare the evolution of the blackbody normalization with flux in the cooling tail of bursts with predictions from spectral models of Suleimanov et al. The observations are well described by the models at luminosities greater than about one-third of the peak luminosity, with deviations emerging at luminosities below that. We show that this comparison leads to distance-independent upper limits on R{sub {infinity}} and neutron star mass of R{sub {infinity}} {approx}< 9.0-13.2 km and M < 1.2-1.7 M{sub Sun }, respectively, for solar abundance of hydrogen at the photosphere and a range of metallicity and surface gravity. The radius limits are low in comparison to previous measurements. This may be indicative of a subsolar hydrogen fraction in the GS 1826-24 photosphere, or of larger color corrections than that predicted by spectral models. Our analysis also gives an upper limit on the distance to GS 1826-24 of d < 4.0-5.5 kpc {xi}{sup -1/2}{sub b}, where {xi}{sub b} is the degree of anisotropy of the burst emission.« less

  12. Entropy of spatial network ensembles

    NASA Astrophysics Data System (ADS)

    Coon, Justin P.; Dettmann, Carl P.; Georgiou, Orestis

    2018-04-01

    We analyze complexity in spatial network ensembles through the lens of graph entropy. Mathematically, we model a spatial network as a soft random geometric graph, i.e., a graph with two sources of randomness, namely nodes located randomly in space and links formed independently between pairs of nodes with probability given by a specified function (the "pair connection function") of their mutual distance. We consider the general case where randomness arises in node positions as well as pairwise connections (i.e., for a given pair distance, the corresponding edge state is a random variable). Classical random geometric graph and exponential graph models can be recovered in certain limits. We derive a simple bound for the entropy of a spatial network ensemble and calculate the conditional entropy of an ensemble given the node location distribution for hard and soft (probabilistic) pair connection functions. Under this formalism, we derive the connection function that yields maximum entropy under general constraints. Finally, we apply our analytical framework to study two practical examples: ad hoc wireless networks and the US flight network. Through the study of these examples, we illustrate that both exhibit properties that are indicative of nearly maximally entropic ensembles.

  13. Fast Radio Bursts’ Recipes for the Distributions of Dispersion Measures, Flux Densities, and Fluences

    NASA Astrophysics Data System (ADS)

    Niino, Yuu

    2018-05-01

    We investigate how the statistical properties of dispersion measure (DM) and apparent flux density/fluence of (nonrepeating) fast radio bursts (FRBs) are determined by unknown cosmic rate density history [ρ FRB(z)] and luminosity function (LF) of the transient events. We predict the distributions of DMs, flux densities, and fluences of FRBs taking account of the variation of the receiver efficiency within its beam, using analytical models of ρ FRB(z) and LF. Comparing the predictions with the observations, we show that the cumulative distribution of apparent fluences suggests that FRBs originate at cosmological distances and ρ FRB increases with redshift resembling the cosmic star formation history (CSFH). We also show that an LF model with a bright-end cutoff at log10 L ν (erg s‑1 Hz‑1) ∼ 34 are favored to reproduce the observed DM distribution if ρ FRB(z) ∝ CSFH, although the statistical significance of the constraints obtained with the current size of the observed sample is not high. Finally, we find that the correlation between DM and flux density of FRBs is potentially a powerful tool to distinguish whether FRBs are at cosmological distances or in the local universe more robustly with future observations.

  14. Flexible Fusion Structure-Based Performance Optimization Learning for Multisensor Target Tracking

    PubMed Central

    Ge, Quanbo; Wei, Zhongliang; Cheng, Tianfa; Chen, Shaodong; Wang, Xiangfeng

    2017-01-01

    Compared with the fixed fusion structure, the flexible fusion structure with mixed fusion methods has better adjustment performance for the complex air task network systems, and it can effectively help the system to achieve the goal under the given constraints. Because of the time-varying situation of the task network system induced by moving nodes and non-cooperative target, and limitations such as communication bandwidth and measurement distance, it is necessary to dynamically adjust the system fusion structure including sensors and fusion methods in a given adjustment period. Aiming at this, this paper studies the design of a flexible fusion algorithm by using an optimization learning technology. The purpose is to dynamically determine the sensors’ numbers and the associated sensors to take part in the centralized and distributed fusion processes, respectively, herein termed sensor subsets selection. Firstly, two system performance indexes are introduced. Especially, the survivability index is presented and defined. Secondly, based on the two indexes and considering other conditions such as communication bandwidth and measurement distance, optimization models for both single target tracking and multi-target tracking are established. Correspondingly, solution steps are given for the two optimization models in detail. Simulation examples are demonstrated to validate the proposed algorithms. PMID:28481243

  15. Models for coupled fluid flow, mineral reaction, and isotopic alteration during contact metamorphism: The Notch Peak aureole, Utah

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ferry, J.M.; Dipple, G.M.

    Three different models were developed to simulate the effect of contact metamorphism and fluid-rock interaction on the prograde mineralogical and O isotopic evolution of calcareous argillites from the Notch Peak aureole, Utah. All models assume local mineral-fluid equilibrium, a steady-state temperature profile corresponding to peak metamorphic values, and the thermodynamic data for minerals and fluid of Berman (1988). The preferred model, metamorphism with flow of a time-integrated fluid flux of 2 {plus minus} 0.5 {center dot} 10{sup 4} mol/cm{sup 2} in the direction of increasing temperature, successfully reproduces the principal petrologic and isotopic features of the aureole: (1) occurrence andmore » positions (in map view) of diopside-in, tremolite-out, grossular-in, wollastonite-in, and quartz-out isograds; (2) stable coexistence of tremolite + calcite + quartz + diopside over an {approx}1 km distance between the diopside-in and tremolite-out isograds; (3) variable whole-rock {sup 18}O depletions of {approx}6-9{per thousand} adjacent to the contact; and (4) a gradual and irregular increase in {delta}{sup 18}O with increasing distance from the pluton. Results demonstrate how isotopic and petrologic data for contact aureoles can be integrated to provide quantitative constraints on the magnitude and geometry of metamorphic fluid flow.« less

  16. Distance Constraint Satisfaction Problems

    NASA Astrophysics Data System (ADS)

    Bodirsky, Manuel; Dalmau, Victor; Martin, Barnaby; Pinsker, Michael

    We study the complexity of constraint satisfaction problems for templates Γ that are first-order definable in ({ Z}; {suc}), the integers with the successor relation. Assuming a widely believed conjecture from finite domain constraint satisfaction (we require the tractability conjecture by Bulatov, Jeavons and Krokhin in the special case of transitive finite templates), we provide a full classification for the case that Γ is locally finite (i.e., the Gaifman graph of Γ has finite degree). We show that one of the following is true: The structure Γ is homomorphically equivalent to a structure with a certain majority polymorphism (which we call modular median) and CSP(Γ) can be solved in polynomial time, or Γ is homomorphically equivalent to a finite transitive structure, or CSP(Γ) is NP-complete.

  17. Manifold Learning by Preserving Distance Orders.

    PubMed

    Ataer-Cansizoglu, Esra; Akcakaya, Murat; Orhan, Umut; Erdogmus, Deniz

    2014-03-01

    Nonlinear dimensionality reduction is essential for the analysis and the interpretation of high dimensional data sets. In this manuscript, we propose a distance order preserving manifold learning algorithm that extends the basic mean-squared error cost function used mainly in multidimensional scaling (MDS)-based methods. We develop a constrained optimization problem by assuming explicit constraints on the order of distances in the low-dimensional space. In this optimization problem, as a generalization of MDS, instead of forcing a linear relationship between the distances in the high-dimensional original and low-dimensional projection space, we learn a non-decreasing relation approximated by radial basis functions. We compare the proposed method with existing manifold learning algorithms using synthetic datasets based on the commonly used residual variance and proposed percentage of violated distance orders metrics. We also perform experiments on a retinal image dataset used in Retinopathy of Prematurity (ROP) diagnosis.

  18. THE SHAPE AND PROFILE OF THE MILKY WAY HALO AS SEEN BY THE CANADA-FRANCE-HAWAII TELESCOPE LEGACY SURVEY

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sesar, Branimir; Ivezic, Zeljko; Juric, Mario, E-mail: bsesar@astro.caltech.edu

    2011-04-10

    We use Canada-France-Hawaii Telescope Legacy Survey data for 170 deg{sup 2}, recalibrated and transformed to the Sloan Digital Sky Survey ugri photometric system, to study the distribution of near-turnoff main-sequence stars in the Galactic halo along four lines of sight to heliocentric distances of {approx}35 kpc. We find that the halo stellar number density profile becomes steeper at Galactocentric distances greater than R{sub gal} {approx} 28 kpc, with the power-law index changing from n{sub inner} = -2.62 {+-} 0.04 to n{sub outer} = -3.8 {+-} 0.1. In particular, we test a series of single power-law models and find them tomore » be strongly disfavored by the data. The parameters for the best-fit Einasto profile are n = 2.2 {+-} 0.2 and R{sub e} = 22.2 {+-} 0.4 kpc. We measure the oblateness of the halo to be q {identical_to} c/a = 0.70 {+-} 0.01 and detect no evidence of it changing across the range of probed distances. The Sagittarius stream is detected in the l = 173 deg. and b = -62 deg. direction as an overdensity of [Fe/H] {approx} -1.5 dex stars at R{sub gal} {approx} 32 kpc, providing a new constraint for the Sagittarius stream and dark matter halo models. We also detect the Monoceros stream as an overdensity of [Fe/H] > -1.5 dex stars in the l = 232 deg. and b = 26 deg. direction at R{sub gal} {approx}< 25 kpc. In the two sight lines where we do not detect significant substructure, the median metallicity is found to be independent of distance within systematic uncertainties ([Fe/H] {approx} -1.5 {+-} 0.1 dex).« less

  19. A Dust-scattering Halo of 4U 1630–47 Observed with Chandra and Swift: New Constraints on the Source Distance

    NASA Astrophysics Data System (ADS)

    Kalemci, E.; Maccarone, T. J.; Tomsick, J. A.

    2018-06-01

    We have observed the Galactic black hole transient 4U 1630‑47 during the decay of its 2016 outburst with Chandra and Swift to investigate the properties of the dust-scattering halo created by the source. The scattering halo shows a structure that includes a bright ring between 80″ and 240″ surrounding the source, and a continuous distribution beyond 250″. An analysis of the 12CO J = 1–0 map and spectrum in the line of sight to the source indicates that a molecular cloud with a radial velocity of ‑79 km s‑1 (denoted MC ‑79) is the main scattering body that creates the bright ring. We found additional clouds in the line of sight, calculated their kinematic distances, and resolved the well known “near” and “far” distance ambiguity for most of the clouds. At the favored far-distance estimate of MC ‑79, the modeling of the surface brightness profile results in a distance to 4U 1630‑47 of 11.5 ± 0.3 kpc. If MC ‑79 is at the near distance, then 4U 1630‑47 is at 4.7 ± 0.3 kpc. Future Chandra, Swift, and submillimeter radio observations not only can resolve this ambiguity, but also would provide information regarding properties of dust and the distribution of all molecular clouds along the line of sight. Using the results of this study we also discuss the nature of this source and the reasons for the observation of an anomalously low soft state during the 2010 decay.

  20. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rao, Nageswara S.; Liu, Qiang

    We consider tracking of a target with elliptical nonlinear constraints on its motion dynamics. The state estimates are generated by sensors and sent over long-haul links to a remote fusion center for fusion. We show that the constraints can be projected onto the known ellipse and hence incorporated into the estimation and fusion process. In particular, two methods based on (i) direct connection to the center, and (ii) shortest distance to the ellipse are discussed. A tracking example is used to illustrate the tracking performance using projection-based methods with various fusers in the lossy long-haul tracking environment.

  1. On the Utility (or Futility) of Using Stable Water Isotopes to Constrain the Bulk Properties of Tropical Convection

    NASA Astrophysics Data System (ADS)

    Duan, Suqin Q.; Wright, Jonathon S.; Romps, David M.

    2018-02-01

    Atmospheric water-vapor isotopes have been proposed as a potentially powerful constraint on convection, which plays a critical role in Earth's present and future climate. It is shown here, however, that the mean tropical profile of HDO in the free troposphere does not usefully constrain the mean convective entrainment rate or precipitation efficiency. This is demonstrated using a single-column analytical model of atmospheric water isotopes. The model has three parameters: the entrainment rate, the precipitation efficiency, and the distance that evaporating condensates fall. At a given relative humidity, the possible range of HDO is small: its range is comparable to both the measurement uncertainty in the mean tropical profile and the structural uncertainty of a single-column model. Therefore, the mean tropical HDO profile is unlikely to add information about convective processes in a bulk-plume framework that cannot already be learned from relative humidity alone.

  2. The clustering of galaxies in the completed SDSS-III Baryon Oscillation Spectroscopic Survey: Single-probe measurements from DR12 galaxy clustering – towards an accurate model

    DOE PAGES

    Chia -Hsun Chuang; Pellejero-Ibanez, Marco; Rodriguez-Torres, Sergio; ...

    2016-06-26

    We analyze the broad-range shape of the monopole and quadrupole correlation functions of the BOSS Data Release 12 (DR12) CMASS and LOWZ galaxy sample to obtain constraints on the Hubble expansion rate H(z), the angular-diameter distance DA(z), the normalised growth rate f(z)σ 8(z), and the physical matter density Ω mh 2. In addition, we adopt wide and flat priors on all model parameters in order to ensure the results are those of a `single-probe' galaxy clustering analysis. We also marginalize over three nuisance terms that account for potential observational systematics affecting the measured monopole. However, such Monte Carlo Markov Chainmore » analysis is computationally expensive for advanced theoretical models, thus we develop a new methodology to speed up our analysis.« less

  3. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lam, P

    Finite element method was used to analyze the three-point bend experimental data of A533B-1 pressure vessel steel obtained by Sherry, Lidbury, and Beardsmore [1] from -160 to -45 C within the ductile-brittle transition regime. As many researchers have shown, the failure stress ({sigma}{sub f}) of the material could be approximated as a constant. The characteristic length, or the critical distance (r{sub c}) from the crack tip, at which {sigma}{sub f} is reached, is shown to be temperature dependent based on the crack tip stress field calculated by the finite element method. With the J-A{sub 2} two-parameter constraint theory in fracturemore » mechanics, the fracture toughness (J{sub C} or K{sub JC}) can be expressed as a function of the constraint level (A{sub 2}) and the critical distance r{sub c}. This relationship is used to predict the fracture toughness of A533B-1 in the ductile-brittle transition regime with a constant {sigma}{sub f} and a set of temperature-dependent r{sub c}. It can be shown that the prediction agrees well with the test data for wide range of constraint levels from shallow cracks (a/W= 0.075) to deep cracks (a/W= 0.5), where a is the crack length and W is the specimen width.« less

  4. Working against gravity: horizontal honeybee waggle runs have greater angular scatter than vertical waggle runs

    PubMed Central

    Couvillon, Margaret J.; Phillipps, Hunter L. F.; Schürch, Roger; Ratnieks, Francis L. W.

    2012-01-01

    The presence of noise in a communication system may be adaptive or may reflect unavoidable constraints. One communication system where these alternatives are debated is the honeybee (Apis mellifera) waggle dance. Successful foragers communicate resource locations to nest-mates by a dance comprising repeated units (waggle runs), which repetitively transmit the same distance and direction vector from the nest. Intra-dance waggle run variation occurs and has been hypothesized as a colony-level adaptation to direct recruits over an area rather than a single location. Alternatively, variation may simply be due to constraints on bees' abilities to orient waggle runs. Here, we ask whether the angle at which the bee dances on vertical comb influences waggle run variation. In particular, we determine whether horizontal dances, where gravity is not aligned with the waggle run orientation, are more variable in their directional component. We analysed 198 dances from foragers visiting natural resources and found support for our prediction. More horizontal dances have greater angular variation than dances performed close to vertical. However, there is no effect of waggle run angle on variation in the duration of waggle runs, which communicates distance. Our results weaken the hypothesis that variation is adaptive and provide novel support for the constraint hypothesis. PMID:22513277

  5. Working against gravity: horizontal honeybee waggle runs have greater angular scatter than vertical waggle runs.

    PubMed

    Couvillon, Margaret J; Phillipps, Hunter L F; Schürch, Roger; Ratnieks, Francis L W

    2012-08-23

    The presence of noise in a communication system may be adaptive or may reflect unavoidable constraints. One communication system where these alternatives are debated is the honeybee (Apis mellifera) waggle dance. Successful foragers communicate resource locations to nest-mates by a dance comprising repeated units (waggle runs), which repetitively transmit the same distance and direction vector from the nest. Intra-dance waggle run variation occurs and has been hypothesized as a colony-level adaptation to direct recruits over an area rather than a single location. Alternatively, variation may simply be due to constraints on bees' abilities to orient waggle runs. Here, we ask whether the angle at which the bee dances on vertical comb influences waggle run variation. In particular, we determine whether horizontal dances, where gravity is not aligned with the waggle run orientation, are more variable in their directional component. We analysed 198 dances from foragers visiting natural resources and found support for our prediction. More horizontal dances have greater angular variation than dances performed close to vertical. However, there is no effect of waggle run angle on variation in the duration of waggle runs, which communicates distance. Our results weaken the hypothesis that variation is adaptive and provide novel support for the constraint hypothesis.

  6. 3D prostate MR-TRUS non-rigid registration using dual optimization with volume-preserving constraint

    NASA Astrophysics Data System (ADS)

    Qiu, Wu; Yuan, Jing; Fenster, Aaron

    2016-03-01

    We introduce an efficient and novel convex optimization-based approach to the challenging non-rigid registration of 3D prostate magnetic resonance (MR) and transrectal ultrasound (TRUS) images, which incorporates a new volume preserving constraint to essentially improve the accuracy of targeting suspicious regions during the 3D TRUS guided prostate biopsy. Especially, we propose a fast sequential convex optimization scheme to efficiently minimize the employed highly nonlinear image fidelity function using the robust multi-channel modality independent neighborhood descriptor (MIND) across the two modalities of MR and TRUS. The registration accuracy was evaluated using 10 patient images by calculating the target registration error (TRE) using manually identified corresponding intrinsic fiducials in the whole prostate gland. We also compared the MR and TRUS manually segmented prostate surfaces in the registered images in terms of the Dice similarity coefficient (DSC), mean absolute surface distance (MAD), and maximum absolute surface distance (MAXD). Experimental results showed that the proposed method with the introduced volume-preserving prior significantly improves the registration accuracy comparing to the method without the volume-preserving constraint, by yielding an overall mean TRE of 2:0+/-0:7 mm, and an average DSC of 86:5+/-3:5%, MAD of 1:4+/-0:6 mm and MAXD of 6:5+/-3:5 mm.

  7. The Information Superhighway: A Review of Some Determining Factors.

    ERIC Educational Resources Information Center

    Cawkell, Tony

    1997-01-01

    Examines consumer services delivered via the Internet. Discusses social and political factors (regulation, commercial alliances, copyright), specific applications (home banking and shopping, distance education, electronic mail, games, telecommuting), and constraints of data transmission. Since many applications are based on videoconferencing,…

  8. 3-D model-based vehicle tracking.

    PubMed

    Lou, Jianguang; Tan, Tieniu; Hu, Weiming; Yang, Hao; Maybank, Steven J

    2005-10-01

    This paper aims at tracking vehicles from monocular intensity image sequences and presents an efficient and robust approach to three-dimensional (3-D) model-based vehicle tracking. Under the weak perspective assumption and the ground-plane constraint, the movements of model projection in the two-dimensional image plane can be decomposed into two motions: translation and rotation. They are the results of the corresponding movements of 3-D translation on the ground plane (GP) and rotation around the normal of the GP, which can be determined separately. A new metric based on point-to-line segment distance is proposed to evaluate the similarity between an image region and an instantiation of a 3-D vehicle model under a given pose. Based on this, we provide an efficient pose refinement method to refine the vehicle's pose parameters. An improved EKF is also proposed to track and to predict vehicle motion with a precise kinematics model. Experimental results with both indoor and outdoor data show that the algorithm obtains desirable performance even under severe occlusion and clutter.

  9. Acceleration constraints in modeling and control of nonholonomic systems

    NASA Astrophysics Data System (ADS)

    Bajodah, Abdulrahman H.

    2003-10-01

    Acceleration constraints are used to enhance modeling techniques for dynamical systems. In particular, Kane's equations of motion subjected to bilateral constraints, unilateral constraints, and servo-constraints are modified by utilizing acceleration constraints for the purpose of simplifying the equations and increasing their applicability. The tangential properties of Kane's method provide relationships between the holonomic and the nonholonomic partial velocities, and hence allow one to describe nonholonomic generalized active and inertia forces in terms of their holonomic counterparts, i.e., those which correspond to the system without constraints. Therefore, based on the modeling process objectives, the holonomic and the nonholonomic vector entities in Kane's approach are used interchangeably to model holonomic and nonholonomic systems. When the holonomic partial velocities are used to model nonholonomic systems, the resulting models are full-order (also called nonminimal or unreduced) and separated in accelerations. As a consequence, they are readily integrable and can be used for generic system analysis. Other related topics are constraint forces, numerical stability of the nonminimal equations of motion, and numerical constraint stabilization. Two types of unilateral constraints considered are impulsive and friction constraints. Impulsive constraints are modeled by means of a continuous-in-velocities and impulse-momentum approaches. In controlled motion, the acceleration form of constraints is utilized with the Moore-Penrose generalized inverse of the corresponding constraint matrix to solve for the inverse dynamics of servo-constraints, and for the redundancy resolution of overactuated manipulators. If control variables are involved in the algebraic constraint equations, then these tools are used to modify the controlled equations of motion in order to facilitate control system design. An illustrative example of spacecraft stabilization is presented.

  10. Modeling the cometary environment using a fluid approach

    NASA Astrophysics Data System (ADS)

    Shou, Yinsi

    Comets are believed to have preserved the building material of the early solar system and to hold clues to the origin of life on Earth. Abundant remote observations of comets by telescopes and the in-situ measurements by a handful of space missions reveal that the cometary environments are complicated by various physical and chemical processes among the neutral gases and dust grains released from comets, cometary ions, and the solar wind in the interplanetary space. Therefore, physics-based numerical models are in demand to interpret the observational data and to deepen our understanding of the cometary environment. In this thesis, three models using a fluid approach, which include important physical and chemical processes underlying the cometary environment, have been developed to study the plasma, neutral gas, and the dust grains, respectively. Although models based on the fluid approach have limitations in capturing all of the correct physics for certain applications, especially for very low gas density environment, they are computationally much more efficient than alternatives. In the simulations of comet 67P/Churyumov-Gerasimenko at various heliocentric distances with a wide range of production rates, our multi-fluid cometary neutral gas model and multi-fluid cometary dust model have achieved comparable results to the Direct Simulation Monte Carlo (DSMC) model, which is based on a kinetic approach that is valid in all collisional regimes. Therefore, our model is a powerful alternative to the particle-based model, especially for some computationally intensive simulations. Capable of accounting for the varying heating efficiency under various physical conditions in a self-consistent way, the multi-fluid cometary neutral gas model is a good tool to study the dynamics of the cometary coma with different production rates and heliocentric distances. The modeled H2O expansion speeds reproduce the general trend and the speed's nonlinear dependencies of production rate and heliocentric distance, which are found in remote observations. In the multi-fluid dust model, we use a newly developed numerical mesh to resolve the real shaped nucleus in the center and to facilitate prescription of the outer boundary conditions that accommodate the rotating frame. The model studies the effects of the rotating nucleus and the cometary activity in time-dependent simulations for the first time. The result also suggests that the rotation of the nucleus explains why there is no clear dust speed dependence on size in some of the dust observations. We developed a new multi-species comet MHD model to simulate the plasma environment of comet C/2006 P1 (McNaught) over a wide range of heliocentric distances from 0.17 AU to 1.75 AU, with the constraints provided by remote and in situ observations. Typical subsolar standoff distances of bow shock and contact surface are modeled and presented to characterize the solar wind interaction of the comet at various heliocentric distances. In addition, the model is also the first one to be used to study the composition and dynamics in the distant cometary tail. The results agree well with the measured water group ion abundances from the Ulysses/SWICS 1.7 AU down-tail from the comet and the velocity and temperature measured by Ulysses/SWOOPS.

  11. Kinematic Distances: A Monte Carlo Method

    NASA Astrophysics Data System (ADS)

    Wenger, Trey V.; Balser, Dana S.; Anderson, L. D.; Bania, T. M.

    2018-03-01

    Distances to high-mass star-forming regions (HMSFRs) in the Milky Way are a crucial constraint on the structure of the Galaxy. Only kinematic distances are available for a majority of the HMSFRs in the Milky Way. Here, we compare the kinematic and parallax distances of 75 Galactic HMSFRs to assess the accuracy of kinematic distances. We derive the kinematic distances using three different methods: the traditional method using the Brand & Blitz rotation curve (Method A), the traditional method using the Reid et al. rotation curve and updated solar motion parameters (Method B), and a Monte Carlo technique (Method C). Methods B and C produce kinematic distances closest to the parallax distances, with median differences of 13% (0.43 {kpc}) and 17% (0.42 {kpc}), respectively. Except in the vicinity of the tangent point, the kinematic distance uncertainties derived by Method C are smaller than those of Methods A and B. In a large region of the Galaxy, the Method C kinematic distances constrain both the distances and the Galactocentric positions of HMSFRs more accurately than parallax distances. Beyond the tangent point along ℓ = 30°, for example, the Method C kinematic distance uncertainties reach a minimum of 10% of the parallax distance uncertainty at a distance of 14 {kpc}. We develop a prescription for deriving and applying the Method C kinematic distances and distance uncertainties. The code to generate the Method C kinematic distances is publicly available and may be utilized through an online tool.

  12. An adaptive Fuzzy C-means method utilizing neighboring information for breast tumor segmentation in ultrasound images.

    PubMed

    Feng, Yuan; Dong, Fenglin; Xia, Xiaolong; Hu, Chun-Hong; Fan, Qianmin; Hu, Yanle; Gao, Mingyuan; Mutic, Sasa

    2017-07-01

    Ultrasound (US) imaging has been widely used in breast tumor diagnosis and treatment intervention. Automatic delineation of the tumor is a crucial first step, especially for the computer-aided diagnosis (CAD) and US-guided breast procedure. However, the intrinsic properties of US images such as low contrast and blurry boundaries pose challenges to the automatic segmentation of the breast tumor. Therefore, the purpose of this study is to propose a segmentation algorithm that can contour the breast tumor in US images. To utilize the neighbor information of each pixel, a Hausdorff distance based fuzzy c-means (FCM) method was adopted. The size of the neighbor region was adaptively updated by comparing the mutual information between them. The objective function of the clustering process was updated by a combination of Euclid distance and the adaptively calculated Hausdorff distance. Segmentation results were evaluated by comparing with three experts' manual segmentations. The results were also compared with a kernel-induced distance based FCM with spatial constraints, the method without adaptive region selection, and conventional FCM. Results from segmenting 30 patient images showed the adaptive method had a value of sensitivity, specificity, Jaccard similarity, and Dice coefficient of 93.60 ± 5.33%, 97.83 ± 2.17%, 86.38 ± 5.80%, and 92.58 ± 3.68%, respectively. The region-based metrics of average symmetric surface distance (ASSD), root mean square symmetric distance (RMSD), and maximum symmetric surface distance (MSSD) were 0.03 ± 0.04 mm, 0.04 ± 0.03 mm, and 1.18 ± 1.01 mm, respectively. All the metrics except sensitivity were better than that of the non-adaptive algorithm and the conventional FCM. Only three region-based metrics were better than that of the kernel-induced distance based FCM with spatial constraints. Inclusion of the pixel neighbor information adaptively in segmenting US images improved the segmentation performance. The results demonstrate the potential application of the method in breast tumor CAD and other US-guided procedures. © 2017 American Association of Physicists in Medicine.

  13. HOW FAR AWAY ARE THE SOURCES OF ICECUBE NEUTRINOS? CONSTRAINTS FROM THE DIFFUSE TERAELECTRONVOLT GAMMA-RAY BACKGROUND

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chang, Xiao-Chuan; Liu, Ruo-Yu; Wang, Xiang-Yu, E-mail: xywang@nju.edu.cn

    The nearly isotropic distribution of teraelectronvolt to petaelectronvolt neutrinos recently detected by the IceCube Collaboration suggests that they come from sources at a distance beyond our Galaxy, but how far away they are is largely unknown because of a lack of any associations with known sources. In this paper, we propose that the cumulative TeV gamma-ray emission accompanying the production of neutrinos can be used to constrain the distance of these neutrino sources, since the opacity of TeV gamma rays due to absorption by the extragalactic background light depends on the distance these TeV gamma rays have traveled. As themore » diffuse extragalactic TeV background measured by Fermi is much weaker than the expected cumulative flux associated with IceCube neutrinos, the majority of IceCube neutrinos, if their sources are transparent to TeV gamma rays, must come from distances larger than the horizon of TeV gamma rays. We find that above 80% of the IceCube neutrinos should come from sources at redshift z > 0.5. Thus, the chance of finding nearby sources correlated with IceCube neutrinos would be small. We also find that, to explain the flux of neutrinos under the TeV gamma-ray emission constraint, the redshift evolution of neutrino source density must be at least as fast as the cosmic star formation rate.« less

  14. The Non-Axisymmetric Milky Way

    NASA Technical Reports Server (NTRS)

    Spergel, David N.

    1996-01-01

    The Dwek et al. model represents the current state-of-the-art model for the stellar structure of our Galaxy. The improvements we have made to this model take a number of forms: (1) the construction of a more detailed dust model so that we can extend our modeling to the galactic plane; (2) simultaneous fits to the bulge and the disk; (3) the construction of the first self-consistent model for a galactic bar; and (4) the development and application of algorithms for constructing nonparametric bar models. The improved Galaxy model has enabled a number of exciting science projects. In Zhao et al., we show that the number and duration of microlensing events seen by the OGLE and MACHO collaborations towards the bulge were consistent with the predictions of our bar model. In Malhotra et al., we constructed an infrared Tully-Fisher (TF) relation for the local group. We found the tightest TF relation ever seen in any band and in any group of galaxies. The tightness of the correlation places strong constraints on galaxy formation models and provides a independent check of the Cepheid distance scale.

  15. An Equivalent Fracture Modeling Method

    NASA Astrophysics Data System (ADS)

    Li, Shaohua; Zhang, Shujuan; Yu, Gaoming; Xu, Aiyun

    2017-12-01

    3D fracture network model is built based on discrete fracture surfaces, which are simulated based on fracture length, dip, aperture, height and so on. The interesting area of Wumishan Formation of Renqiu buried hill reservoir is about 57 square kilometer and the thickness of target strata is more than 2000 meters. In addition with great fracture density, the fracture simulation and upscaling of discrete fracture network model of Wumishan Formation are very intense computing. In order to solve this problem, a method of equivalent fracture modeling is proposed. First of all, taking the fracture interpretation data obtained from imaging logging and conventional logging as the basic data, establish the reservoir level model, and then under the constraint of reservoir level model, take fault distance analysis model as the second variable, establish fracture density model by Sequential Gaussian Simulation method. Increasing the width, height and length of fracture, at the same time decreasing its density in order to keep the similar porosity and permeability after upscaling discrete fracture network model. In this way, the fracture model of whole interesting area can be built within an accepted time.

  16. On obtaining neutron-star mass and radius constraints from quiescent low-mass X-ray binaries in the Galactic plane

    NASA Astrophysics Data System (ADS)

    Marino, Alessio; Degenaar, N.; Di Salvo, T.; Wijnands, R.; Burderi, L.; Iaria, R.

    2018-06-01

    X-ray spectral analysis of quiescent low-mass X-ray binaries (LMXBs) has been one of the most common tools to measure the radius of neutron stars (NSs) for over a decade. So far, this method has been mainly applied to NSs in globular clusters, primarily because of their well-constrained distances. Here, we study Chandra data of seven transient LMXBs in the Galactic plane in quiescence to investigate the potential of constraining the radius (and mass) of the NSs inhabiting these systems. We find that only two of these objects had X-ray spectra of sufficient quality to obtain reasonable constraints on the radius, with the most stringent being an upper limit of R ≲14.5 km for EXO 0748-676 (for assumed ranges for mass and distance). Using these seven sources, we also investigate systematic biases on the mass/radius determination; for Aql X-1 we find that omitting a power-law spectral component when it does not seem to be required by the data, results in peculiar trends in the obtained radius with changing mass and distance. For EXO 0748-676 we find that a slight variation in the lower limit of the energy range chosen for the fit leads to systematically different masses and radii. Finally, we simulated Athena spectra and found that some of the biases can be lifted when higher quality spectra are available and that, in general, the search for constraints on the equation of state of ultra-dense matter via NS radius and mass measurements may receive a considerable boost in the future.

  17. Homonuclear 1H NMR and circular dichroism study of the HIV-1 Tat Eli variant

    PubMed Central

    Watkins, Jennifer D; Campbell, Grant R; Halimi, Hubert; Loret, Erwann P

    2008-01-01

    Background The HIV-1 Tat protein is a promising target to develop AIDS therapies, particularly vaccines, due to its extracellular role that protects HIV-1-infected cells from the immune system. Tat exists in two different lengths, 86 or 87 residues and 99 or 101 residues, with the long form being predominant in clinical isolates. We report here a structural study of the 99 residue Tat Eli variant using 2D liquid-state NMR, molecular modeling and circular dichroism. Results Tat Eli was obtained from solid-phase peptide synthesis and the purified protein was proven biologically active in a trans-activation assay. Circular dichroism spectra at different temperatures up to 70°C showed that Tat Eli is not a random coil at 20°C. Homonuclear 1H NMR spectra allowed us to identify 1639 NMR distance constraints out of which 264 were interresidual. Molecular modeling satisfying at least 1474 NMR constraints revealed the same folding for different model structures. The Tat Eli model has a core region composed of a part of the N-terminus including the highly conserved Trp 11. The extra residues in the Tat Eli C-terminus protrude from a groove between the basic region and the cysteine-rich region and are well exposed to the solvent. Conclusion We show that active Tat variants share a similar folding pattern whatever their size, but mutations induce local structural changes. PMID:18808674

  18. Plasticity-Driven Self-Organization under Topological Constraints Accounts for Non-random Features of Cortical Synaptic Wiring

    PubMed Central

    Miner, Daniel; Triesch, Jochen

    2016-01-01

    Understanding the structure and dynamics of cortical connectivity is vital to understanding cortical function. Experimental data strongly suggest that local recurrent connectivity in the cortex is significantly non-random, exhibiting, for example, above-chance bidirectionality and an overrepresentation of certain triangular motifs. Additional evidence suggests a significant distance dependency to connectivity over a local scale of a few hundred microns, and particular patterns of synaptic turnover dynamics, including a heavy-tailed distribution of synaptic efficacies, a power law distribution of synaptic lifetimes, and a tendency for stronger synapses to be more stable over time. Understanding how many of these non-random features simultaneously arise would provide valuable insights into the development and function of the cortex. While previous work has modeled some of the individual features of local cortical wiring, there is no model that begins to comprehensively account for all of them. We present a spiking network model of a rodent Layer 5 cortical slice which, via the interactions of a few simple biologically motivated intrinsic, synaptic, and structural plasticity mechanisms, qualitatively reproduces these non-random effects when combined with simple topological constraints. Our model suggests that mechanisms of self-organization arising from a small number of plasticity rules provide a parsimonious explanation for numerous experimentally observed non-random features of recurrent cortical wiring. Interestingly, similar mechanisms have been shown to endow recurrent networks with powerful learning abilities, suggesting that these mechanism are central to understanding both structure and function of cortical synaptic wiring. PMID:26866369

  19. Self-supervised online metric learning with low rank constraint for scene categorization.

    PubMed

    Cong, Yang; Liu, Ji; Yuan, Junsong; Luo, Jiebo

    2013-08-01

    Conventional visual recognition systems usually train an image classifier in a bath mode with all training data provided in advance. However, in many practical applications, only a small amount of training samples are available in the beginning and many more would come sequentially during online recognition. Because the image data characteristics could change over time, it is important for the classifier to adapt to the new data incrementally. In this paper, we present an online metric learning method to address the online scene recognition problem via adaptive similarity measurement. Given a number of labeled data followed by a sequential input of unseen testing samples, the similarity metric is learned to maximize the margin of the distance among different classes of samples. By considering the low rank constraint, our online metric learning model not only can provide competitive performance compared with the state-of-the-art methods, but also guarantees convergence. A bi-linear graph is also defined to model the pair-wise similarity, and an unseen sample is labeled depending on the graph-based label propagation, while the model can also self-update using the more confident new samples. With the ability of online learning, our methodology can well handle the large-scale streaming video data with the ability of incremental self-updating. We evaluate our model to online scene categorization and experiments on various benchmark datasets and comparisons with state-of-the-art methods demonstrate the effectiveness and efficiency of our algorithm.

  20. Galaxy clusters in local Universe simulations without density constraints: a long uphill struggle

    NASA Astrophysics Data System (ADS)

    Sorce, Jenny G.

    2018-06-01

    Galaxy clusters are excellent cosmological probes provided that their formation and evolution within the large scale environment are precisely understood. Therefore studies with simulated galaxy clusters have flourished. However detailed comparisons between simulated and observed clusters and their population - the galaxies - are complicated by the diversity of clusters and their surrounding environment. An original way initiated by Bertschinger as early as 1987, to legitimize the one-to-one comparison exercise down to the details, is to produce simulations constrained to resemble the cluster under study within its large scale environment. Subsequently several methods have emerged to produce simulations that look like the local Universe. This paper highlights one of these methods and its essential steps to get simulations that not only resemble the local Large Scale Structure but also that host the local clusters. It includes a new modeling of the radial peculiar velocity uncertainties to remove the observed correlation between the decreases of the simulated cluster masses and of the amount of data used as constraints with the distance from us. This method has the particularity to use solely radial peculiar velocities as constraints: no additional density constraints are required to get local cluster simulacra. The new resulting simulations host dark matter halos that match the most prominent local clusters such as Coma. Zoom-in simulations of the latter and of a volume larger than the 30h-1 Mpc radius inner sphere become now possible to study local clusters and their effects. Mapping the local Sunyaev-Zel'dovich and Sachs-Wolfe effects can follow.

  1. NEPTUNE'S WILD DAYS: CONSTRAINTS FROM THE ECCENTRICITY DISTRIBUTION OF THE CLASSICAL KUIPER BELT

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dawson, Rebekah I.; Murray-Clay, Ruth, E-mail: rdawson@cfa.harvard.edu

    2012-05-01

    Neptune's dynamical history shaped the current orbits of Kuiper Belt objects (KBOs), leaving clues to the planet's orbital evolution. In the 'classical' region, a population of dynamically 'hot' high-inclination KBOs overlies a flat 'cold' population with distinct physical properties. Simulations of qualitatively different histories for Neptune, including smooth migration on a circular orbit or scattering by other planets to a high eccentricity, have not simultaneously produced both populations. We explore a general Kuiper Belt assembly model that forms hot classical KBOs interior to Neptune and delivers them to the classical region, where the cold population forms in situ. First, wemore » present evidence that the cold population is confined to eccentricities well below the limit dictated by long-term survival. Therefore, Neptune must deliver hot KBOs into the long-term survival region without excessively exciting the eccentricities of the cold population. Imposing this constraint, we explore the parameter space of Neptune's eccentricity and eccentricity damping, migration, and apsidal precession. We rule out much of parameter space, except where Neptune is scattered to a moderately eccentric orbit (e > 0.15) and subsequently migrates a distance {Delta}a{sub N} = 1-6 AU. Neptune's moderate eccentricity must either damp quickly or be accompanied by fast apsidal precession. We find that Neptune's high eccentricity alone does not generate a chaotic sea in the classical region. Chaos can result from Neptune's interactions with Uranus, exciting the cold KBOs and placing additional constraints. Finally, we discuss how to interpret our constraints in the context of the full, complex dynamical history of the solar system.« less

  2. Reddening, distance modulus and age of the globular cluster NGC 6121 (M4) from the properties of RR Lyrae variables

    NASA Astrophysics Data System (ADS)

    Caputo, F.; Castellani, V.; Quarta, M. L.

    1985-02-01

    It is shown that pulsational properties of RR Lyrae variables in globular clusters can be used to put theoretical constraints on the values of cluster reddening and distance modulus. By requiring that the HR diagram location of pulsators agrees with the period distribution observed and with the theoretical boundaries of the instability strip, reddening and distance modulus of the globular cluster M4 are derived as a (slow) function of the pulsator masses. Thus, a best guess is presented for the cluster age (t = 12.2 billion years), some evidence for a non-canonical evolutionary having been taken into account.

  3. Conformation and Dynamics of a Flexible Sheet in Solvent Media by Monte Carlo Simulations

    NASA Astrophysics Data System (ADS)

    Pandey, Ras; Anderson, Kelly; Heinz, Hendrik; Farmer, Barry

    2005-03-01

    Flexibility of the clay sheet is limited even in the ex-foliated state in some solvent media. A coarse grained model is used to investigate dynamics and conformation of a flexible sheet to model such a clay platelet in an effective solvent medium on a cubic lattice of size L^3 with lattice constant a. The undeformed sheet is described by a square lattice of size Ls^2, where, each node of the sheet is represented by the unit cube of the cubic lattice and 2a is the minimum distance between the nearest neighbor nodes to incorporate the excluded volume constraints. Additionally, each node interacts with neighboring nodes and solvent (empty) sites within a range ri. Each node execute their stochastic motion with the Metropolis algorithm subject to bond length fluctuation and excluded volume constraints. Mean square displacements of the center node and that of its center of mass are investigated as a function of time step for a set of these parameters. The radius of gyration (Rg) is also examined concurrently to understand its relaxation. Multi-scale segmental dynamics of the sheet is studied by identifying the power-law dependence in various time regimes. Relaxation of Rg and its dependence of temperature are planned to be discussed.

  4. Multi-target detection and positioning in crowds using multiple camera surveillance

    NASA Astrophysics Data System (ADS)

    Huang, Jiahu; Zhu, Qiuyu; Xing, Yufeng

    2018-04-01

    In this study, we propose a pixel correspondence algorithm for positioning in crowds based on constraints on the distance between lines of sight, grayscale differences, and height in a world coordinates system. First, a Gaussian mixture model is used to obtain the background and foreground from multi-camera videos. Second, the hair and skin regions are extracted as regions of interest. Finally, the correspondences between each pixel in the region of interest are found under multiple constraints and the targets are positioned by pixel clustering. The algorithm can provide appropriate redundancy information for each target, which decreases the risk of losing targets due to a large viewing angle and wide baseline. To address the correspondence problem for multiple pixels, we construct a pixel-based correspondence model based on a similar permutation matrix, which converts the correspondence problem into a linear programming problem where a similar permutation matrix is found by minimizing an objective function. The correct pixel correspondences can be obtained by determining the optimal solution of this linear programming problem and the three-dimensional position of the targets can also be obtained by pixel clustering. Finally, we verified the algorithm with multiple cameras in experiments, which showed that the algorithm has high accuracy and robustness.

  5. MEASURING NEUTRON STAR RADII VIA PULSE PROFILE MODELING WITH NICER

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Özel, Feryal; Psaltis, Dimitrios; Bauböck, Michi

    2016-11-20

    The Neutron-star Interior Composition Explorer is an X-ray astrophysics payload that will be placed on the International Space Station . Its primary science goal is to measure with high accuracy the pulse profiles that arise from the non-uniform thermal surface emission of rotation-powered pulsars. Modeling general relativistic effects on the profiles will lead to measuring the radii of these neutron stars and to constraining their equation of state. Achieving this goal will depend, among other things, on accurate knowledge of the source, sky, and instrument backgrounds. We use here simple analytic estimates to quantify the level at which these backgroundsmore » need to be known in order for the upcoming measurements to provide significant constraints on the properties of neutron stars. We show that, even in the minimal-information scenario, knowledge of the background at a few percent level for a background-to-source countrate ratio of 0.2 allows for a measurement of the neutron star compactness to better than 10% uncertainty for most of the parameter space. These constraints improve further when more realistic assumptions are made about the neutron star emission and spin, and when additional information about the source itself, such as its mass or distance, are incorporated.« less

  6. Photo-reverberation Mapping of a Protoplanetary Accretion Disk around a T Tauri Star

    NASA Astrophysics Data System (ADS)

    Meng, Huan; Plavchan, Peter; Rieke, George

    2016-01-01

    Theoretical models and spectroscopic observations of newborn stars suggest that protoplantary disks have an inner "wall" at a distance set by the disk interaction with the star. Around T Tauri stars, the size of this disk hole is expected to be on a 0.1-AU scale that is unresolved by current adaptive optics imaging, though some model-dependent constraints have been obtained by near-infrared interferometry. Here we report the first measurement of the inner disk wall around a solar-mass young stellar object, YLW 16B in the ρ Ophiuchi star-forming region, by detecting the light travel time of the variable radiation from the stellar surface to the disk. Consistent time lags were detected on two nights, when the time series in H and K bands were synchronized while the 4.5 μm emission lagged by 74.5±3.2 seconds. Considering the nearly edge-on geometry of the disk, the inner rim should be 0.084±0.004 AU from the protostar on average. This size is likely larger than the range of magnetospheric truncations, but consistent with an optically and geometrically thick disk front at the dust sublimation radius at ~1500 K. The detection of a definite time lag places new constraints on the geometry of the disk.

  7. Time delay in the Einstein ring PKS 1830-211

    NASA Technical Reports Server (NTRS)

    Van Ommen, T. D.; Jones, D. L.; Preston, R. A.; Jauncey, D. L.

    1995-01-01

    We present radio observations of the gravitational lens PKS 1830-211 at 8.4 and 15 GHz acquired using the Very Large Array. The observations were made over a 13 month period. Significant flux density changes over this period provide strong constraints on the time delay between the two lensed images and suffest a value of 44 +/- 9 days. This offers new direct evidence that this source is indeed a gravitational lens. The lens distance is dependent upon the model chosen, but reasonable limits on the mass of the lensing galaxy suggest that it is unlikely to be at a redshift less than a few tenths, and may well be significantly more distant.

  8. Cascading failures in interdependent networks with finite functional components

    NASA Astrophysics Data System (ADS)

    Di Muro, M. A.; Buldyrev, S. V.; Stanley, H. E.; Braunstein, L. A.

    2016-10-01

    We present a cascading failure model of two interdependent networks in which functional nodes belong to components of size greater than or equal to s . We find theoretically and via simulation that in complex networks with random dependency links the transition is first order for s ≥3 and continuous for s =2 . We also study interdependent lattices with a distance constraint r in the dependency links and find that increasing r moves the system from a regime without a phase transition to one with a second-order transition. As r continues to increase, the system collapses in a first-order transition. Each regime is associated with a different structure of domain formation of functional nodes.

  9. Control of minimum member size in parameter-free structural shape optimization by a medial axis approximation

    NASA Astrophysics Data System (ADS)

    Schmitt, Oliver; Steinmann, Paul

    2018-06-01

    We introduce a manufacturing constraint for controlling the minimum member size in structural shape optimization problems, which is for example of interest for components fabricated in a molding process. In a parameter-free approach, whereby the coordinates of the FE boundary nodes are used as design variables, the challenging task is to find a generally valid definition for the thickness of non-parametric geometries in terms of their boundary nodes. Therefore we use the medial axis, which is the union of all points with at least two closest points on the boundary of the domain. Since the effort for the exact computation of the medial axis of geometries given by their FE discretization highly increases with the number of surface elements we use the distance function instead to approximate the medial axis by a cloud of points. The approximation is demonstrated on three 2D examples. Moreover, the formulation of a minimum thickness constraint is applied to a sensitivity-based shape optimization problem of one 2D and one 3D model.

  10. Control of minimum member size in parameter-free structural shape optimization by a medial axis approximation

    NASA Astrophysics Data System (ADS)

    Schmitt, Oliver; Steinmann, Paul

    2017-09-01

    We introduce a manufacturing constraint for controlling the minimum member size in structural shape optimization problems, which is for example of interest for components fabricated in a molding process. In a parameter-free approach, whereby the coordinates of the FE boundary nodes are used as design variables, the challenging task is to find a generally valid definition for the thickness of non-parametric geometries in terms of their boundary nodes. Therefore we use the medial axis, which is the union of all points with at least two closest points on the boundary of the domain. Since the effort for the exact computation of the medial axis of geometries given by their FE discretization highly increases with the number of surface elements we use the distance function instead to approximate the medial axis by a cloud of points. The approximation is demonstrated on three 2D examples. Moreover, the formulation of a minimum thickness constraint is applied to a sensitivity-based shape optimization problem of one 2D and one 3D model.

  11. The clustering of galaxies in the completed SDSS-III Baryon Oscillation Spectroscopic Survey: cosmological analysis of the DR12 galaxy sample

    DOE PAGES

    Alam, Shadab; Ata, Metin; Bailey, Stephen; ...

    2017-03-28

    Here we present cosmological results from the final galaxy clustering data set of the Baryon Oscillation Spectroscopic Survey, part of the Sloan Digital Sky Survey III. Our combined galaxy sample comprises 1.2 million massive galaxies over an effective area of 9329 deg 2 and volume of 18.7 Gpc 3, divided into three partially overlapping redshift slices centred at effective redshifts 0.38, 0.51 and 0.61. We measure the angular diameter distance DM and Hubble parameter H from the baryon acoustic oscillation (BAO) method, in combination with a cosmic microwave background prior on the sound horizon scale, after applying reconstruction to reducemore » non-linear effects on the BAO feature. Using the anisotropic clustering of the pre-reconstruction density field, we measure the product DMH from the Alcock–Paczynski (AP) effect and the growth of structure, quantified by fσ8(z), from redshift-space distortions (RSD). We combine individual measurements presented in seven companion papers into a set of consensus values and likelihoods, obtaining constraints that are tighter and more robust than those from any one method; in particular, the AP measurement from sub-BAO scales sharpens constraints from post-reconstruction BAOs by breaking degeneracy between DM and H. Combined with Planck 2016 cosmic microwave background measurements, our distance scale measurements simultaneously imply curvature ΩK = 0.0003 ± 0.0026 and a dark energy equation-of-state parameter w = -1.01 ± 0.06, in strong affirmation of the spatially flat cold dark matter (CDM) model with a cosmological constant (ΛCDM). Our RSD measurements of fσ8, at 6 per cent precision, are similarly consistent with this model. When combined with supernova Ia data, we find H0 = 67.3 ± 1.0 km s -1 Mpc -1 even for our most general dark energy model, in tension with some direct measurements. Adding extra relativistic species as a degree of freedom loosens the constraint only slightly, to H0 = 67.8 ± 1.2km s -1 Mpc -1. Assuming flat ΛCDM, we find Ωm = 0.310 ± 0.005 and H0 = 67.6 ± 0.5 km s -1 Mpc -1, and we find a 95 per cent upper limit of 0.16 eV c -2 on the neutrino mass sum.« less

  12. The clustering of galaxies in the completed SDSS-III Baryon Oscillation Spectroscopic Survey: cosmological analysis of the DR12 galaxy sample

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Alam, Shadab; Ata, Metin; Bailey, Stephen

    Here we present cosmological results from the final galaxy clustering data set of the Baryon Oscillation Spectroscopic Survey, part of the Sloan Digital Sky Survey III. Our combined galaxy sample comprises 1.2 million massive galaxies over an effective area of 9329 deg 2 and volume of 18.7 Gpc 3, divided into three partially overlapping redshift slices centred at effective redshifts 0.38, 0.51 and 0.61. We measure the angular diameter distance DM and Hubble parameter H from the baryon acoustic oscillation (BAO) method, in combination with a cosmic microwave background prior on the sound horizon scale, after applying reconstruction to reducemore » non-linear effects on the BAO feature. Using the anisotropic clustering of the pre-reconstruction density field, we measure the product DMH from the Alcock–Paczynski (AP) effect and the growth of structure, quantified by fσ8(z), from redshift-space distortions (RSD). We combine individual measurements presented in seven companion papers into a set of consensus values and likelihoods, obtaining constraints that are tighter and more robust than those from any one method; in particular, the AP measurement from sub-BAO scales sharpens constraints from post-reconstruction BAOs by breaking degeneracy between DM and H. Combined with Planck 2016 cosmic microwave background measurements, our distance scale measurements simultaneously imply curvature ΩK = 0.0003 ± 0.0026 and a dark energy equation-of-state parameter w = -1.01 ± 0.06, in strong affirmation of the spatially flat cold dark matter (CDM) model with a cosmological constant (ΛCDM). Our RSD measurements of fσ8, at 6 per cent precision, are similarly consistent with this model. When combined with supernova Ia data, we find H0 = 67.3 ± 1.0 km s -1 Mpc -1 even for our most general dark energy model, in tension with some direct measurements. Adding extra relativistic species as a degree of freedom loosens the constraint only slightly, to H0 = 67.8 ± 1.2km s -1 Mpc -1. Assuming flat ΛCDM, we find Ωm = 0.310 ± 0.005 and H0 = 67.6 ± 0.5 km s -1 Mpc -1, and we find a 95 per cent upper limit of 0.16 eV c -2 on the neutrino mass sum.« less

  13. The depth estimation of 3D face from single 2D picture based on manifold learning constraints

    NASA Astrophysics Data System (ADS)

    Li, Xia; Yang, Yang; Xiong, Hailiang; Liu, Yunxia

    2018-04-01

    The estimation of depth is virtual important in 3D face reconstruction. In this paper, we propose a t-SNE based on manifold learning constraints and introduce K-means method to divide the original database into several subset, and the selected optimal subset to reconstruct the 3D face depth information can greatly reduce the computational complexity. Firstly, we carry out the t-SNE operation to reduce the key feature points in each 3D face model from 1×249 to 1×2. Secondly, the K-means method is applied to divide the training 3D database into several subset. Thirdly, the Euclidean distance between the 83 feature points of the image to be estimated and the feature point information before the dimension reduction of each cluster center is calculated. The category of the image to be estimated is judged according to the minimum Euclidean distance. Finally, the method Kong D will be applied only in the optimal subset to estimate the depth value information of 83 feature points of 2D face images. Achieving the final depth estimation results, thus the computational complexity is greatly reduced. Compared with the traditional traversal search estimation method, although the proposed method error rate is reduced by 0.49, the number of searches decreases with the change of the category. In order to validate our approach, we use a public database to mimic the task of estimating the depth of face images from 2D images. The average number of searches decreased by 83.19%.

  14. Vowel Deletion in Latvian.

    ERIC Educational Resources Information Center

    Karins, A. Krisjanis

    1995-01-01

    Investigates variable deletion of short vowels in word-final unstressed syllables in Latvian spoken in Riga. Affected vowels were almost always inflectional endings and results indicated that internal phonological and prosodic factors (especially distance from main word stress) were the strongest constraints on vowel deletion, along with the…

  15. Constraining the baryon-dark matter relative velocity with the large-scale 3-point correlation function of the SDSS BOSS DR12 CMASS galaxies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Slepian, Zachary; Slosar, Anze; Eisenstein, Daniel J.

    We search for a galaxy clustering bias due to a modulation of galaxy number with the baryon-dark matter relative velocity resulting from recombination-era physics. We find no detected signal and place the constraint bv <0.01 on the relative velocity bias for the CMASS galaxies. This bias is an important potential systematic of Baryon Acoustic Oscillation (BAO) method measurements of the cosmic distance scale using the 2-point clustering. Our limit on the relative velocity bias indicates a systematic shift of no more than 0.3% rms in the distance scale inferred from the BAO feature in the BOSS 2-point clustering, well belowmore » the 1% statistical error of this measurement. In conclusion, this constraint is the most stringent currently available and has important implications for the ability of upcoming large-scale structure surveys such as DESI to self-protect against the relative velocity as a possible systematic.« less

  16. Polynomial Size Formulations for the Distance and Capacity Constrained Vehicle Routing Problem

    NASA Astrophysics Data System (ADS)

    Kara, Imdat; Derya, Tusan

    2011-09-01

    The Distance and Capacity Constrained Vehicle Routing Problem (DCVRP) is an extension of the well known Traveling Salesman Problem (TSP). DCVRP arises in distribution and logistics problems. It would be beneficial to construct new formulations, which is the main motivation and contribution of this paper. We focused on two indexed integer programming formulations for DCVRP. One node based and one arc (flow) based formulation for DCVRP are presented. Both formulations have O(n2) binary variables and O(n2) constraints, i.e., the number of the decision variables and constraints grows with a polynomial function of the nodes of the underlying graph. It is shown that proposed arc based formulation produces better lower bound than the existing one (this refers to the Water's formulation in the paper). Finally, various problems from literature are solved with the node based and arc based formulations by using CPLEX 8.0. Preliminary computational analysis shows that, arc based formulation outperforms the node based formulation in terms of linear programming relaxation.

  17. Distance-informed metric learning for Alzheimer's disease staging.

    PubMed

    Shi, Bibo; Wang, Zhewei; Liu, Jundong

    2014-01-01

    Identifying intermediate biomarkers of Alzheimer's disease (AD) is of great importance for diagnosis and prognosis of the disease. In this study, we develop a new AD staging method to classify patients into Normal Controls (NC), Mild Cognitive Impairment (MCI), and AD groups. Our solution employs a novel metric learning technique that improves classification rates through the guidance of some weak supervisory information in AD progression. More specifically, those information are in the form of pairwise constraints that specify the relative Mini Mental State Examination (MMSE) score disparity of two subjects, depending on whether they are in the same group or not. With the imposed constraints, the common knowledge that MCI generally sits in between of NC and AD can be integrated into the classification distance metric. Subjects from the Alzheimer's Disease Neuroimaging Initiative cohort (ADNI; 56 AD, 104 MCI, 161 controls) were used to demonstrate the improvements made comparing with two state-of-the-art metric learning solutions: large margin nearest neighbors (LMNN) and relevant component analysis (RCA).

  18. Constraining the baryon-dark matter relative velocity with the large-scale 3-point correlation function of the SDSS BOSS DR12 CMASS galaxies

    DOE PAGES

    Slepian, Zachary; Slosar, Anze; Eisenstein, Daniel J.; ...

    2017-10-24

    We search for a galaxy clustering bias due to a modulation of galaxy number with the baryon-dark matter relative velocity resulting from recombination-era physics. We find no detected signal and place the constraint bv <0.01 on the relative velocity bias for the CMASS galaxies. This bias is an important potential systematic of Baryon Acoustic Oscillation (BAO) method measurements of the cosmic distance scale using the 2-point clustering. Our limit on the relative velocity bias indicates a systematic shift of no more than 0.3% rms in the distance scale inferred from the BAO feature in the BOSS 2-point clustering, well belowmore » the 1% statistical error of this measurement. In conclusion, this constraint is the most stringent currently available and has important implications for the ability of upcoming large-scale structure surveys such as DESI to self-protect against the relative velocity as a possible systematic.« less

  19. Constraining the baryon-dark matter relative velocity with the large-scale three-point correlation function of the SDSS BOSS DR12 CMASS galaxies

    NASA Astrophysics Data System (ADS)

    Slepian, Zachary; Eisenstein, Daniel J.; Blazek, Jonathan A.; Brownstein, Joel R.; Chuang, Chia-Hsun; Gil-Marín, Héctor; Ho, Shirley; Kitaura, Francisco-Shu; McEwen, Joseph E.; Percival, Will J.; Ross, Ashley J.; Rossi, Graziano; Seo, Hee-Jong; Slosar, Anže; Vargas-Magaña, Mariana

    2018-02-01

    We search for a galaxy clustering bias due to a modulation of galaxy number with the baryon-dark matter relative velocity resulting from recombination-era physics. We find no detected signal and place the constraint bv < 0.01 on the relative velocity bias for the CMASS galaxies. This bias is an important potential systematic of baryon acoustic oscillation (BAO) method measurements of the cosmic distance scale using the two-point clustering. Our limit on the relative velocity bias indicates a systematic shift of no more than 0.3 per cent rms in the distance scale inferred from the BAO feature in the BOSS two-point clustering, well below the 1 per cent statistical error of this measurement. This constraint is the most stringent currently available and has important implications for the ability of upcoming large-scale structure surveys such as the Dark Energy Spectroscopic Instrument (DESI) to self-protect against the relative velocity as a possible systematic.

  20. Map Projection Induced Variations in Locations of Polygon Geofence Edges

    NASA Technical Reports Server (NTRS)

    Neeley, Paula; Narkawicz, Anthony

    2017-01-01

    This Paper under-estimates answers to the following question under various constraints: If a geofencing algorithm uses a map projection to determine whether a position is inside/outside a polygon region, how far outside/inside the polygon can the point be and the algorithm determine that it is inside/outside (the opposite and therefore incorrect answer)? Geofencing systems for unmanned aircraft systems (UAS) often model stay-in and stay-out regions using 2D polygons with minimum and maximum altitudes. The vertices of the polygons are typically input as latitude-longitude pairs, and the edges as paths between adjacent vertices. There are numerous ways to generate these paths, resulting in numerous potential locations for the edges of stay-in and stay-out regions. These paths may be geodesics on a spherical model of the earth or geodesics on the WGS84 reference ellipsoid. In geofencing applications that use map projections, these paths are inverse images of straight lines in the projected plane. This projected plane may be a projection of a spherical earth model onto a tangent plane, called an orthographic projection. Alternatively, it may be a projection where the straight lines in the projected plane correspond to straight lines in the latitudelongitude coordinate system, also called a Plate Carr´ee projection. This paper estimates distances between different edge paths and an oracle path, which is a geodesic on either the spherical earth or the WGS84 ellipsoidal earth. This paper therefore estimates how far apart different edge paths can be rather than comparing their path lengths, which are not considered. Rather, the comparision is between the actual locations of the edges between vertices. For edges drawn using orthographic projections, this maximum distance increases as the distance from the polygon vertices to the projection point increases. For edges drawn using Plate Carr´ee projections, this maximum distance increases as the vertices become further from the equator. Distances between geodesics on a spherical earth and a WGS84 ellipsoidal earth are also analyzed, using the WGS84 ellipsoid as the oracle. Bounds on the 2D distance between a straight line and a great circle path, in an orthographically projected plane rather than on the surface of the earth, have been formally verified in the PVS theorem prover, meaning that they are mathematically correct in the absence of floating point errors.

  1. A methodology for improving the spatial framework for secondary education: An example from trinidad and tobago

    NASA Astrophysics Data System (ADS)

    London, Norrel A.

    1992-03-01

    Following a period of massive quantitative increases in education provision in the 1970's and 1980's, many Third World nations now find it difficult to provide additional school places to improve their present system of education provision. Strapped by financial constraints on the one hand, and on the other by pressing demands for efficient and effective services, developing nations have been encouraged to adopt judicious and careful spatial planning as a way out of the present dilemma. The paper uses a technical model to demonstrate how Trinidad and Tobago may reduce the problem of a lengthy journey-to-school, currently faced by many secondary school students. Paradoxically, this results from the Government's efforts to expand the system of secondary education during the past two decades. Using an index of distance travelled between home and school, the paper evaluates the geographic location of eight schools that have been proposed for construction by Trinidad and Tobago, and recommends alternative locations that would more effectively and more quickly achieve the Government's objective of minimizing home-to-school distances now travelled by secondary students. The rank order in which the proposed eight schools ought to be built, so as to achieve distance minimization with incremental addition of each new facility is also suggested.

  2. Non-LTE spectral analysis and model constraints on SN 1993J

    NASA Technical Reports Server (NTRS)

    Baron, E.; Hauschildt, P. H.; Branch, D.; Austin, S.; Garnavich, P.; Ann, Hong Bae; Wagner, R. M.; Filippenko, A. V.; Matheson, T.; Liebert, James

    1995-01-01

    We present non-Local Thermodynamic Equilibrium (LTE) synthetic spectra for a time series of observations of SN 1993J obtained on 1993 March 30-31, April 7, April 13-15, and June 13 UT. The spectra are dominated by hydrogen Balmer lines; neutral helium lines, which have been nonthermally excited; and Fe II features. The density profile evolves from an extremely steep 'brick wall' structure with an equivalent power-law index of about 50 on March 30 to a more typical SN II profile with a power law index of about 10. The early spectra are well fitted by a solar composition of metals, although an enhanced abundance of helium is required in order to fit the neutral helium lines. By June 13, the photosphere has receded deep into the helium layer, although there appears to be a layer of hydrogen at higher velocity. The distance is estimated for each epoch. While consistent results are found for spectra obtained in the month of April, the spread in distances from March to June is quite large. Our value for April is mu = 28.0 +/- 0.3 mag, consistent with the recent Cepheid distance to the host galaxy M81. We also compare our results to other implementations of the expanding photosphere method.

  3. Analysis of point-to-point lung motion with full inspiration and expiration CT data using non-linear optimization method: optimal geometric assumption model for the effective registration algorithm

    NASA Astrophysics Data System (ADS)

    Kim, Namkug; Seo, Joon Beom; Heo, Jeong Nam; Kang, Suk-Ho

    2007-03-01

    The study was conducted to develop a simple model for more robust lung registration of volumetric CT data, which is essential for various clinical lung analysis applications, including the lung nodule matching in follow up CT studies, semi-quantitative assessment of lung perfusion, and etc. The purpose of this study is to find the most effective reference point and geometric model based on the lung motion analysis from the CT data sets obtained in full inspiration (In.) and expiration (Ex.). Ten pairs of CT data sets in normal subjects obtained in full In. and Ex. were used in this study. Two radiologists were requested to draw 20 points representing the subpleural point of the central axis in each segment. The apex, hilar point, and center of inertia (COI) of each unilateral lung were proposed as the reference point. To evaluate optimal expansion point, non-linear optimization without constraints was employed. The objective function is sum of distances from the line, consist of the corresponding points between In. and Ex. to the optimal point x. By using the nonlinear optimization, the optimal points was evaluated and compared between reference points. The average distance between the optimal point and each line segment revealed that the balloon model was more suitable to explain the lung expansion model. This lung motion analysis based on vector analysis and non-linear optimization shows that balloon model centered on the center of inertia of lung is most effective geometric model to explain lung expansion by breathing.

  4. Limits on the Higgs boson lifetime and width from its decay to four charged leptons

    NASA Astrophysics Data System (ADS)

    Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; Knünz, V.; König, A.; Krammer, M.; Krätschmer, I.; Liko, D.; Matsushita, T.; Mikulec, I.; Rabady, D.; Rahbaran, B.; Rohringer, H.; Schieck, J.; Schöfbeck, R.; Strauss, J.; Treberer-Treberspurg, W.; Waltenberger, W.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Suarez Gonzalez, J.; Alderweireldt, S.; Cornelis, T.; de Wolf, E. A.; Janssen, X.; Knutsson, A.; Lauwers, J.; Luyckx, S.; Ochesanu, S.; Rougny, R.; van de Klundert, M.; van Haevermaet, H.; van Mechelen, P.; van Remortel, N.; van Spilbeeck, A.; Abu Zeid, S.; Blekman, F.; D'Hondt, J.; Daci, N.; de Bruyn, I.; Deroover, K.; Heracleous, N.; Keaveney, J.; Lowette, S.; Moreels, L.; Olbrechts, A.; Python, Q.; Strom, D.; Tavernier, S.; van Doninck, W.; van Mulders, P.; van Onsem, G. P.; van Parijs, I.; Barria, P.; Caillol, C.; Clerbaux, B.; de Lentdecker, G.; Delannoy, H.; Fasanella, G.; Favart, L.; Gay, A. P. R.; Grebenyuk, A.; Lenzi, T.; Léonard, A.; Maerschalk, T.; Marinov, A.; Perniè, L.; Randle-Conde, A.; Reis, T.; Seva, T.; Vander Velde, C.; Vanlaer, P.; Yonamine, R.; Zenoni, F.; Zhang, F.; Beernaert, K.; Benucci, L.; Cimmino, A.; Crucy, S.; Dobur, D.; Fagot, A.; Garcia, G.; Gul, M.; McCartin, J.; Ocampo Rios, A. A.; Poyraz, D.; Ryckbosch, D.; Salva, S.; Sigamani, M.; Strobbe, N.; Tytgat, M.; van Driessche, W.; Yazgan, E.; Zaganidis, N.; Basegmez, S.; Beluffi, C.; Bondu, O.; Brochet, S.; Bruno, G.; Castello, R.; Caudron, A.; Ceard, L.; da Silveira, G. G.; Delaere, C.; Favart, D.; Forthomme, L.; Giammanco, A.; Hollar, J.; Jafari, A.; Jez, P.; Komm, M.; Lemaitre, V.; Mertens, A.; Nuttens, C.; Perrini, L.; Pin, A.; Piotrzkowski, K.; Popov, A.; Quertenmont, L.; Selvaggi, M.; Vidal Marono, M.; Beliy, N.; Hammad, G. H.; Aldá Júnior, W. L.; Alves, G. A.; Brito, L.; Correa Martins Junior, M.; Hamer, M.; Hensel, C.; Mora Herrera, C.; Moraes, A.; Pol, M. E.; Rebello Teles, P.; Belchior Batista Das Chagas, E.; Carvalho, W.; Chinellato, J.; Custódio, A.; da Costa, E. M.; de Jesus Damiao, D.; de Oliveira Martins, C.; Fonseca de Souza, S.; Huertas Guativa, L. M.; Malbouisson, H.; Matos Figueiredo, D.; Mundim, L.; Nogima, H.; Prado da Silva, W. L.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Vilela Pereira, A.; Ahuja, S.; Bernardes, C. A.; de Souza Santos, A.; Dogra, S.; Tomei, T. R. Fernandez Perez; Gregores, E. M.; Mercadante, P. G.; Moon, C. S.; Novaes, S. F.; Padula, Sandra S.; Romero Abad, D.; Ruiz Vargas, J. C.; Aleksandrov, A.; Genchev, V.; Hadjiiska, R.; Iaydjiev, P.; Piperov, S.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Litov, L.; Pavlov, B.; Petkov, P.; Ahmad, M.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Cheng, T.; Du, R.; Jiang, C. H.; Plestina, R.; Romeo, F.; Shaheen, S. M.; Tao, J.; Wang, C.; Wang, Z.; Zhang, H.; Asawatangtrakuldee, C.; Ban, Y.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Xu, Z.; Zou, W.; Avila, C.; Cabrera, A.; Chaparro Sierra, L. F.; Florez, C.; Gomez, J. P.; Gomez Moreno, B.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Polic, D.; Puljak, I.; Ribeiro Cipriano, P. M.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Kadija, K.; Luetic, J.; Micanovic, S.; Sudic, L.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. 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S.; Junkes, A.; Klanner, R.; Kogler, R.; Lapsien, T.; Lenz, T.; Marchesini, I.; Marconi, D.; Nowatschin, D.; Ott, J.; Pantaleo, F.; Peiffer, T.; Perieanu, A.; Pietsch, N.; Poehlsen, J.; Rathjens, D.; Sander, C.; Schettler, H.; Schleper, P.; Schlieckau, E.; Schmidt, A.; Schwandt, J.; Seidel, M.; Sola, V.; Stadie, H.; Steinbrück, G.; Tholen, H.; Troendle, D.; Usai, E.; Vanelderen, L.; Vanhoefer, A.; Akbiyik, M.; Barth, C.; Baus, C.; Berger, J.; Böser, C.; Butz, E.; Chwalek, T.; Colombo, F.; de Boer, W.; Descroix, A.; Dierlamm, A.; Fink, S.; Frensch, F.; Giffels, M.; Gilbert, A.; Hartmann, F.; Heindl, S. M.; Husemann, U.; Katkov, I.; Kornmayer, A.; Lobelle Pardo, P.; Maier, B.; Mildner, H.; Mozer, M. U.; Müller, T.; Müller, Th.; Plagge, M.; Quast, G.; Rabbertz, K.; Röcker, S.; Roscher, F.; Simonis, H. J.; Stober, F. M.; Ulrich, R.; Wagner-Kuhr, J.; Wayand, S.; Weber, M.; Weiler, T.; Wöhrmann, C.; Wolf, R.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. A.; Kyriakis, A.; Loukas, D.; Psallidas, A.; Topsis-Giotis, I.; Agapitos, A.; Kesisoglou, S.; Panagiotou, A.; Saoulidou, N.; Tziaferi, E.; Evangelou, I.; Flouris, G.; Foudas, C.; Kokkas, P.; Loukas, N.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Strologas, J.; Bencze, G.; Hajdu, C.; Hazi, A.; Hidas, P.; Horvath, D.; Sikler, F.; Veszpremi, V.; Vesztergombi, G.; Zsigmond, A. J.; Beni, N.; Czellar, S.; Karancsi, J.; Molnar, J.; Szillasi, Z.; Bartók, M.; Makovec, A.; Raics, P.; Trocsanyi, Z. L.; Ujvari, B.; Mal, P.; Mandal, K.; Sahoo, N.; Swain, S. K.; Bansal, S.; Beri, S. B.; Bhatnagar, V.; Chawla, R.; Gupta, R.; Bhawandeep, U.; Kalsi, A. K.; Kaur, A.; Kaur, M.; Kumar, R.; Mehta, A.; Mittal, M.; Singh, J. B.; Walia, G.; Kumar, Ashok; Kumar, Arun; Bhardwaj, A.; Choudhary, B. C.; Garg, R. 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V.; Vinogradov, A.; Baskakov, A.; Belyaev, A.; Boos, E.; Bunichev, V.; Dubinin, M.; Dudko, L.; Ershov, A.; Gribushin, A.; Klyukhin, V.; Kodolova, O.; Lokhtin, I.; Myagkov, I.; Obraztsov, S.; Petrushanko, S.; Savrin, V.; Azhgirey, I.; Bayshev, I.; Bitioukov, S.; Kachanov, V.; Kalinin, A.; Konstantinov, D.; Krychkine, V.; Petrov, V.; Ryutin, R.; Sobol, A.; Tourtchanovitch, L.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Adzic, P.; Ekmedzic, M.; Milosevic, J.; Rekovic, V.; Alcaraz Maestre, J.; Calvo, E.; Cerrada, M.; Chamizo Llatas, M.; Colino, N.; de La Cruz, B.; Delgado Peris, A.; Domínguez Vázquez, D.; Escalante Del Valle, A.; Fernandez Bedoya, C.; Fernández Ramos, J. P.; Flix, J.; Fouz, M. C.; Garcia-Abia, P.; Gonzalez Lopez, O.; Goy Lopez, S.; Hernandez, J. M.; Josa, M. I.; Navarro de Martino, E.; Pérez-Calero Yzquierdo, A.; Puerta Pelayo, J.; Quintario Olmeda, A.; Redondo, I.; Romero, L.; Soares, M. S.; Albajar, C.; de Trocóniz, J. F.; Missiroli, M.; Moran, D.; Brun, H.; Cuevas, J.; Fernandez Menendez, J.; Folgueras, S.; Gonzalez Caballero, I.; Palencia Cortezon, E.; Vizan Garcia, J. M.; Cabrillo, I. J.; Calderon, A.; Castiñeiras de Saa, J. R.; de Castro Manzano, P.; Duarte Campderros, J.; Fernandez, M.; Gomez, G.; Graziano, A.; Lopez Virto, A.; Marco, J.; Marco, R.; Martinez Rivero, C.; Matorras, F.; Munoz Sanchez, F. J.; Piedra Gomez, J.; Rodrigo, T.; Rodríguez-Marrero, A. Y.; Ruiz-Jimeno, A.; Scodellaro, L.; Vila, I.; Vilar Cortabitarte, R.; Abbaneo, D.; Auffray, E.; Auzinger, G.; Bachtis, M.; Baillon, P.; Ball, A. H.; Barney, D.; Benaglia, A.; Bendavid, J.; Benhabib, L.; Benitez, J. F.; Berruti, G. M.; Bloch, P.; Bocci, A.; Bonato, A.; Botta, C.; Breuker, H.; Camporesi, T.; Cerminara, G.; Colafranceschi, S.; D'Alfonso, M.; D'Enterria, D.; Dabrowski, A.; Daponte, V.; David, A.; de Gruttola, M.; de Guio, F.; de Roeck, A.; de Visscher, S.; di Marco, E.; Dobson, M.; Dordevic, M.; Dorney, B.; Du Pree, T.; Dupont, N.; Elliott-Peisert, A.; Franzoni, G.; Funk, W.; Gigi, D.; Gill, K.; Giordano, D.; Girone, M.; Glege, F.; Guida, R.; Gundacker, S.; Guthoff, M.; Hammer, J.; Harris, P.; Hegeman, J.; Innocente, V.; Janot, P.; Kirschenmann, H.; Kortelainen, M. J.; Kousouris, K.; Krajczar, K.; Lecoq, P.; Lourenço, C.; Lucchini, M. T.; Magini, N.; Malgeri, L.; Mannelli, M.; Martelli, A.; Masetti, L.; Meijers, F.; Mersi, S.; Meschi, E.; Moortgat, F.; Morovic, S.; Mulders, M.; Nemallapudi, M. V.; Neugebauer, H.; Orfanelli, S.; Orsini, L.; Pape, L.; Perez, E.; Petrilli, A.; Petrucciani, G.; Pfeiffer, A.; Piparo, D.; Racz, A.; Rolandi, G.; Rovere, M.; Ruan, M.; Sakulin, H.; Schäfer, C.; Schwick, C.; Sharma, A.; Silva, P.; Simon, M.; Sphicas, P.; Spiga, D.; Steggemann, J.; Stieger, B.; Stoye, M.; Takahashi, Y.; Treille, D.; Triossi, A.; Tsirou, A.; Veres, G. I.; Wardle, N.; Wöhri, H. K.; Zagozdzinska, A.; Zeuner, W. D.; Bertl, W.; Deiters, K.; Erdmann, W.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; Kotlinski, D.; Langenegger, U.; Renker, D.; Rohe, T.; Bachmair, F.; Bäni, L.; Bianchini, L.; Buchmann, M. A.; Casal, B.; Dissertori, G.; Dittmar, M.; Donegà, M.; Dünser, M.; Eller, P.; Grab, C.; Heidegger, C.; Hits, D.; Hoss, J.; Kasieczka, G.; Lustermann, W.; Mangano, B.; Marini, A. C.; Marionneau, M.; Martinez Ruiz Del Arbol, P.; Masciovecchio, M.; Meister, D.; Musella, P.; Nessi-Tedaldi, F.; Pandolfi, F.; Pata, J.; Pauss, F.; Perrozzi, L.; Peruzzi, M.; Quittnat, M.; Rossini, M.; Starodumov, A.; Takahashi, M.; Tavolaro, V. R.; Theofilatos, K.; Wallny, R.; Aarrestad, T. K.; Amsler, C.; Caminada, L.; Canelli, M. F.; Chiochia, V.; de Cosa, A.; Galloni, C.; Hinzmann, A.; Hreus, T.; Kilminster, B.; Lange, C.; Ngadiuba, J.; Pinna, D.; Robmann, P.; Ronga, F. J.; Salerno, D.; Yang, Y.; Cardaci, M.; Chen, K. H.; Doan, T. H.; Ferro, C.; Jain, Sh.; Khurana, R.; Konyushikhin, M.; Kuo, C. M.; Lin, W.; Lu, Y. J.; Volpe, R.; Yu, S. S.; Bartek, R.; Chang, P.; Chang, Y. H.; Chang, Y. W.; Chao, Y.; Chen, K. F.; Chen, P. H.; Dietz, C.; Fiori, F.; Grundler, U.; Hou, W.-S.; Hsiung, Y.; Liu, Y. F.; Lu, R.-S.; Miñano Moya, M.; Petrakou, E.; Tsai, J. F.; Tzeng, Y. M.; Asavapibhop, B.; Kovitanggoon, K.; Singh, G.; Srimanobhas, N.; Suwonjandee, N.; Adiguzel, A.; Cerci, S.; Dozen, C.; Girgis, S.; Gokbulut, G.; Guler, Y.; Gurpinar, E.; Hos, I.; Kangal, E. E.; Kayis Topaksu, A.; Onengut, G.; Ozdemir, K.; Ozturk, S.; Tali, B.; Topakli, H.; Vergili, M.; Zorbilmez, C.; Akin, I. V.; Bilin, B.; Bilmis, S.; Isildak, B.; Karapinar, G.; Surat, U. E.; Yalvac, M.; Zeyrek, M.; Albayrak, E. A.; Gülmez, E.; Kaya, M.; Kaya, O.; Yetkin, T.; Cankocak, K.; Sen, S.; Vardarlı, F. I.; Grynyov, B.; Levchuk, L.; Sorokin, P.; Aggleton, R.; Ball, F.; Beck, L.; Brooke, J. J.; Clement, E.; Cussans, D.; Flacher, H.; Goldstein, J.; Grimes, M.; Heath, G. P.; Heath, H. F.; Jacob, J.; Kreczko, L.; Lucas, C.; Meng, Z.; Newbold, D. M.; Paramesvaran, S.; Poll, A.; Sakuma, T.; Seif El Nasr-Storey, S.; Senkin, S.; Smith, D.; Smith, V. J.; Bell, K. W.; Belyaev, A.; Brew, C.; Brown, R. M.; Cockerill, D. J. A.; Coughlan, J. A.; Harder, K.; Harper, S.; Olaiya, E.; Petyt, D.; Shepherd-Themistocleous, C. H.; Thea, A.; Thomas, L.; Tomalin, I. R.; Williams, T.; Womersley, W. J.; Worm, S. D.; Baber, M.; Bainbridge, R.; Buchmuller, O.; Bundock, A.; Burton, D.; Casasso, S.; Citron, M.; Colling, D.; Corpe, L.; Cripps, N.; Dauncey, P.; Davies, G.; de Wit, A.; Della Negra, M.; Dunne, P.; Elwood, A.; Ferguson, W.; Fulcher, J.; Futyan, D.; Hall, G.; Iles, G.; Karapostoli, G.; Kenzie, M.; Lane, R.; Lucas, R.; Lyons, L.; Magnan, A.-M.; Malik, S.; Nash, J.; Nikitenko, A.; Pela, J.; Pesaresi, M.; Petridis, K.; Raymond, D. M.; Richards, A.; Rose, A.; Seez, C.; Tapper, A.; Uchida, K.; Vazquez Acosta, M.; Virdee, T.; Zenz, S. C.; Cole, J. E.; Hobson, P. R.; Khan, A.; Kyberd, P.; Leggat, D.; Leslie, D.; Reid, I. D.; Symonds, P.; Teodorescu, L.; Turner, M.; Borzou, A.; Call, K.; Dittmann, J.; Hatakeyama, K.; Kasmi, A.; Liu, H.; Pastika, N.; Charaf, O.; Cooper, S. I.; Henderson, C.; Rumerio, P.; Avetisyan, A.; Bose, T.; Fantasia, C.; Gastler, D.; Lawson, P.; Rankin, D.; Richardson, C.; Rohlf, J.; St. John, J.; Sulak, L.; Zou, D.; Alimena, J.; Berry, E.; Bhattacharya, S.; Cutts, D.; Dhingra, N.; Ferapontov, A.; Garabedian, A.; Heintz, U.; Laird, E.; Landsberg, G.; Mao, Z.; Narain, M.; Sagir, S.; Sinthuprasith, T.; Breedon, R.; Breto, G.; Calderon de La Barca Sanchez, M.; Chauhan, S.; Chertok, M.; Conway, J.; Conway, R.; Cox, P. T.; Erbacher, R.; Gardner, M.; Ko, W.; Lander, R.; Mulhearn, M.; Pellett, D.; Pilot, J.; Ricci-Tam, F.; Shalhout, S.; Smith, J.; Squires, M.; Stolp, D.; Tripathi, M.; Wilbur, S.; Yohay, R.; Cousins, R.; Everaerts, P.; Farrell, C.; Hauser, J.; Ignatenko, M.; Saltzberg, D.; Takasugi, E.; Valuev, V.; Weber, M.; Burt, K.; Clare, R.; Ellison, J.; Gary, J. W.; Hanson, G.; Heilman, J.; Ivova Paneva, M.; Jandir, P.; Kennedy, E.; Lacroix, F.; Long, O. R.; Luthra, A.; Malberti, M.; Olmedo Negrete, M.; Shrinivas, A.; Wei, H.; Wimpenny, S.; Branson, J. G.; Cerati, G. B.; Cittolin, S.; D'Agnolo, R. T.; Holzner, A.; Kelley, R.; Klein, D.; Letts, J.; MacNeill, I.; Olivito, D.; Padhi, S.; Pieri, M.; Sani, M.; Sharma, V.; Simon, S.; Tadel, M.; Vartak, A.; Wasserbaech, S.; Welke, C.; Würthwein, F.; Yagil, A.; Zevi Della Porta, G.; Barge, D.; Bradmiller-Feld, J.; Campagnari, C.; Dishaw, A.; Dutta, V.; Flowers, K.; Franco Sevilla, M.; Geffert, P.; George, C.; Golf, F.; Gouskos, L.; Gran, J.; Incandela, J.; Justus, C.; McColl, N.; Mullin, S. D.; Richman, J.; Stuart, D.; Suarez, I.; To, W.; West, C.; Yoo, J.; Anderson, D.; Apresyan, A.; Bornheim, A.; Bunn, J.; Chen, Y.; Duarte, J.; Mott, A.; Newman, H. B.; Pena, C.; Pierini, M.; Spiropulu, M.; Vlimant, J. R.; Xie, S.; Zhu, R. Y.; Azzolini, V.; Calamba, A.; Carlson, B.; Ferguson, T.; Iiyama, Y.; Paulini, M.; Russ, J.; Sun, M.; Vogel, H.; Vorobiev, I.; Cumalat, J. P.; Ford, W. T.; Gaz, A.; Jensen, F.; Johnson, A.; Krohn, M.; Mulholland, T.; Nauenberg, U.; Smith, J. G.; Stenson, K.; Wagner, S. R.; Alexander, J.; Chatterjee, A.; Chaves, J.; Chu, J.; Dittmer, S.; Eggert, N.; Mirman, N.; Nicolas Kaufman, G.; Patterson, J. R.; Rinkevicius, A.; Ryd, A.; Skinnari, L.; Soffi, L.; Sun, W.; Tan, S. M.; Teo, W. D.; Thom, J.; Thompson, J.; Tucker, J.; Weng, Y.; Wittich, P.; Abdullin, S.; Albrow, M.; Anderson, J.; Apollinari, G.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bolla, G.; Burkett, K.; Butler, J. N.; Cheung, H. W. K.; Chlebana, F.; Cihangir, S.; Elvira, V. D.; Fisk, I.; Freeman, J.; Gottschalk, E.; Gray, L.; Green, D.; Grünendahl, S.; Gutsche, O.; Hanlon, J.; Hare, D.; Harris, R. M.; Hirschauer, J.; Hooberman, B.; Hu, Z.; Jindariani, S.; Johnson, M.; Joshi, U.; Jung, A. W.; Klima, B.; Kreis, B.; Kwan, S.; Lammel, S.; Linacre, J.; Lincoln, D.; Lipton, R.; Liu, T.; Lopes de Sá, R.; Lykken, J.; Maeshima, K.; Marraffino, J. M.; Martinez Outschoorn, V. I.; Maruyama, S.; Mason, D.; McBride, P.; Merkel, P.; Mishra, K.; Mrenna, S.; Nahn, S.; Newman-Holmes, C.; O'Dell, V.; Pedro, K.; Prokofyev, O.; Rakness, G.; Sexton-Kennedy, E.; Soha, A.; Spalding, W. J.; Spiegel, L.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vernieri, C.; Verzocchi, M.; Vidal, R.; Weber, H. A.; Whitbeck, A.; Yang, F.; Yin, H.; Acosta, D.; Avery, P.; Bortignon, P.; Bourilkov, D.; Carnes, A.; Carver, M.; Curry, D.; Das, S.; di Giovanni, G. P.; Field, R. D.; Fisher, M.; Furic, I. K.; Hugon, J.; Konigsberg, J.; Korytov, A.; Low, J. F.; Ma, P.; Matchev, K.; Mei, H.; Milenovic, P.; Mitselmakher, G.; Muniz, L.; Rank, D.; Rossin, R.; Shchutska, L.; Snowball, M.; Sperka, D.; Wang, J.; Wang, S.; Yelton, J.; Hewamanage, S.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Ackert, A.; Adams, J. R.; Adams, T.; Askew, A.; Bochenek, J.; Diamond, B.; Haas, J.; Hagopian, S.; Hagopian, V.; Johnson, K. F.; Khatiwada, A.; Prosper, H.; Veeraraghavan, V.; Weinberg, M.; Bhopatkar, V.; Hohlmann, M.; Kalakhety, H.; Mareskas-Palcek, D.; Roy, T.; Yumiceva, F.; Adams, M. R.; Apanasevich, L.; Berry, D.; Betts, R. R.; Bucinskaite, I.; Cavanaugh, R.; Evdokimov, O.; Gauthier, L.; Gerber, C. E.; Hofman, D. J.; Kurt, P.; O'Brien, C.; Sandoval Gonzalez, I. D.; Silkworth, C.; Turner, P.; Varelas, N.; Wu, Z.; Zakaria, M.; Bilki, B.; Clarida, W.; Dilsiz, K.; Durgut, S.; Gandrajula, R. P.; Haytmyradov, M.; Khristenko, V.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Snyder, C.; Tan, P.; Tiras, E.; Wetzel, J.; Yi, K.; Anderson, I.; Barnett, B. A.; Blumenfeld, B.; Fehling, D.; Feng, L.; Gritsan, A. V.; Maksimovic, P.; Martin, C.; Osherson, M.; Roskes, J.; Sarica, U.; Swartz, M.; Xiao, M.; Xin, Y.; You, C.; Baringer, P.; Bean, A.; Benelli, G.; Bruner, C.; Gray, J.; Kenny, R. P.; Majumder, D.; Malek, M.; Murray, M.; Noonan, D.; Sanders, S.; Stringer, R.; Wang, Q.; Wood, J. S.; Chakaberia, I.; Ivanov, A.; Kaadze, K.; Khalil, S.; Makouski, M.; Maravin, Y.; Mohammadi, A.; Saini, L. K.; Skhirtladze, N.; Svintradze, I.; Toda, S.; Lange, D.; Rebassoo, F.; Wright, D.; Anelli, C.; Baden, A.; Baron, O.; Belloni, A.; Calvert, B.; Eno, S. C.; Ferraioli, C.; Gomez, J. A.; Hadley, N. J.; Jabeen, S.; Kellogg, R. G.; Kolberg, T.; Kunkle, J.; Lu, Y.; Mignerey, A. C.; Shin, Y. H.; Skuja, A.; Tonjes, M. B.; Tonwar, S. C.; Apyan, A.; Barbieri, R.; Baty, A.; Bierwagen, K.; Brandt, S.; Busza, W.; Cali, I. A.; Demiragli, Z.; Di Matteo, L.; Gomez Ceballos, G.; Goncharov, M.; Gulhan, D.; Innocenti, G. M.; Klute, M.; Kovalskyi, D.; Lai, Y. S.; Lee, Y.-J.; Levin, A.; Luckey, P. D.; McGinn, C.; Mironov, C.; Niu, X.; Paus, C.; Ralph, D.; Roland, C.; Roland, G.; Salfeld-Nebgen, J.; Stephans, G. S. F.; Sumorok, K.; Varma, M.; Velicanu, D.; Veverka, J.; Wang, J.; Wang, T. W.; Wyslouch, B.; Yang, M.; Zhukova, V.; Dahmes, B.; Finkel, A.; Gude, A.; Hansen, P.; Kalafut, S.; Kao, S. C.; Klapoetke, K.; Kubota, Y.; Lesko, Z.; Mans, J.; Nourbakhsh, S.; Ruckstuhl, N.; Rusack, R.; Tambe, N.; Turkewitz, J.; Acosta, J. G.; Oliveros, S.; Avdeeva, E.; Bloom, K.; Bose, S.; Claes, D. R.; Dominguez, A.; Fangmeier, C.; Gonzalez Suarez, R.; Kamalieddin, R.; Keller, J.; Knowlton, D.; Kravchenko, I.; Lazo-Flores, J.; Meier, F.; Monroy, J.; Ratnikov, F.; Siado, J. E.; Snow, G. R.; Alyari, M.; Dolen, J.; George, J.; Godshalk, A.; Iashvili, I.; Kaisen, J.; Kharchilava, A.; Kumar, A.; Rappoccio, S.; Alverson, G.; Barberis, E.; Baumgartel, D.; Chasco, M.; Hortiangtham, A.; Massironi, A.; Morse, D. M.; Nash, D.; Orimoto, T.; Teixeira de Lima, R.; Trocino, D.; Wang, R.-J.; Wood, D.; Zhang, J.; Hahn, K. A.; Kubik, A.; Mucia, N.; Odell, N.; Pollack, B.; Pozdnyakov, A.; Schmitt, M.; Stoynev, S.; Sung, K.; Trovato, M.; Velasco, M.; Won, S.; Brinkerhoff, A.; Dev, N.; Hildreth, M.; Jessop, C.; Karmgard, D. J.; Kellams, N.; Lannon, K.; Lynch, S.; Marinelli, N.; Meng, F.; Mueller, C.; Musienko, Y.; Pearson, T.; Planer, M.; Reinsvold, A.; Ruchti, R.; Smith, G.; Taroni, S.; Valls, N.; Wayne, M.; Wolf, M.; Woodard, A.; Antonelli, L.; Brinson, J.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Hart, A.; Hill, C.; Hughes, R.; Kotov, K.; Ling, T. Y.; Liu, B.; Luo, W.; Puigh, D.; Rodenburg, M.; Winer, B. L.; Wulsin, H. W.; Driga, O.; Elmer, P.; Hardenbrook, J.; Hebda, P.; Koay, S. A.; Lujan, P.; Marlow, D.; Medvedeva, T.; Mooney, M.; Olsen, J.; Palmer, C.; Piroué, P.; Quan, X.; Saka, H.; Stickland, D.; Tully, C.; Werner, J. S.; Zuranski, A.; Malik, S.; Barnes, V. E.; Benedetti, D.; Bortoletto, D.; Gutay, L.; Jha, M. K.; Jones, M.; Jung, K.; Kress, M.; Miller, D. H.; Neumeister, N.; Primavera, F.; Radburn-Smith, B. C.; Shi, X.; Shipsey, I.; Silvers, D.; Sun, J.; Svyatkovskiy, A.; Wang, F.; Xie, W.; Xu, L.; Zablocki, J.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Chen, Z.; Ecklund, K. M.; Geurts, F. J. M.; Guilbaud, M.; Li, W.; Michlin, B.; Northup, M.; Padley, B. P.; Redjimi, R.; Roberts, J.; Rorie, J.; Tu, Z.; Zabel, J.; Betchart, B.; Bodek, A.; de Barbaro, P.; Demina, R.; Eshaq, Y.; Ferbel, T.; Galanti, M.; Garcia-Bellido, A.; Goldenzweig, P.; Han, J.; Harel, A.; Hindrichs, O.; Khukhunaishvili, A.; Petrillo, G.; Verzetti, M.; Demortier, L.; Arora, S.; Barker, A.; Chou, J. P.; Contreras-Campana, C.; Contreras-Campana, E.; Duggan, D.; Ferencek, D.; Gershtein, Y.; Gray, R.; Halkiadakis, E.; Hidas, D.; Hughes, E.; Kaplan, S.; Kunnawalkam Elayavalli, R.; Lath, A.; Nash, K.; Panwalkar, S.; Park, M.; Salur, S.; Schnetzer, S.; Sheffield, D.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Foerster, M.; Riley, G.; Rose, K.; Spanier, S.; York, A.; Bouhali, O.; Castaneda Hernandez, A.; Dalchenko, M.; de Mattia, M.; Delgado, A.; Dildick, S.; Eusebi, R.; Flanagan, W.; Gilmore, J.; Kamon, T.; Krutelyov, V.; Montalvo, R.; Mueller, R.; Osipenkov, I.; Pakhotin, Y.; Patel, R.; Perloff, A.; Roe, J.; Rose, A.; Safonov, A.; Tatarinov, A.; Ulmer, K. A.; Akchurin, N.; Cowden, C.; Damgov, J.; Dragoiu, C.; Dudero, P. R.; Faulkner, J.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Libeiro, T.; Undleeb, S.; Volobouev, I.; Appelt, E.; Delannoy, A. G.; Greene, S.; Gurrola, A.; Janjam, R.; Johns, W.; Maguire, C.; Mao, Y.; Melo, A.; Sheldon, P.; Snook, B.; Tuo, S.; Velkovska, J.; Xu, Q.; Arenton, M. W.; Boutle, S.; Cox, B.; Francis, B.; Goodell, J.; Hirosky, R.; Ledovskoy, A.; Li, H.; Lin, C.; Neu, C.; Wolfe, E.; Wood, J.; Xia, F.; Clarke, C.; Harr, R.; Karchin, P. E.; Kottachchi Kankanamge Don, C.; Lamichhane, P.; Sturdy, J.; Belknap, D. A.; Carlsmith, D.; Cepeda, M.; Christian, A.; Dasu, S.; Dodd, L.; Duric, S.; Friis, E.; Gomber, B.; Hall-Wilton, R.; Herndon, M.; Hervé, A.; Klabbers, P.; Lanaro, A.; Levine, A.; Long, K.; Loveless, R.; Mohapatra, A.; Ojalvo, I.; Perry, T.; Pierro, G. A.; Polese, G.; Ross, I.; Ruggles, T.; Sarangi, T.; Savin, A.; Sharma, A.; Smith, N.; Smith, W. H.; Taylor, D.; Woods, N.; Cms Collaboration

    2015-10-01

    Constraints on the lifetime and width of the Higgs boson are obtained from H →Z Z →4 ℓ events using data recorded by the CMS experiment during the LHC run 1 with an integrated luminosity of 5.1 and 19.7 fb-1 at a center-of-mass energy of 7 and 8 TeV, respectively. The measurement of the Higgs boson lifetime is derived from its flight distance in the CMS detector with an upper bound of τH<1.9 ×10-13 s at the 95% confidence level (C.L.), corresponding to a lower bound on the width of ΓH>3.5 ×10-9 MeV . The measurement of the width is obtained from an off-shell production technique, generalized to include anomalous couplings of the Higgs boson to two electroweak bosons. From this measurement, a joint constraint is set on the Higgs boson width and a parameter fΛ Q that expresses an anomalous coupling contribution as an on-shell cross-section fraction. The limit on the Higgs boson width is ΓH<46 MeV with fΛ Q unconstrained and ΓH<26 MeV for fΛ Q=0 at the 95% C.L. The constraint fΛ Q<3.8 ×10-3 at the 95% C.L. is obtained for the expected standard model Higgs boson width.

  5. A Poisson nonnegative matrix factorization method with parameter subspace clustering constraint for endmember extraction in hyperspectral imagery

    NASA Astrophysics Data System (ADS)

    Sun, Weiwei; Ma, Jun; Yang, Gang; Du, Bo; Zhang, Liangpei

    2017-06-01

    A new Bayesian method named Poisson Nonnegative Matrix Factorization with Parameter Subspace Clustering Constraint (PNMF-PSCC) has been presented to extract endmembers from Hyperspectral Imagery (HSI). First, the method integrates the liner spectral mixture model with the Bayesian framework and it formulates endmember extraction into a Bayesian inference problem. Second, the Parameter Subspace Clustering Constraint (PSCC) is incorporated into the statistical program to consider the clustering of all pixels in the parameter subspace. The PSCC could enlarge differences among ground objects and helps finding endmembers with smaller spectrum divergences. Meanwhile, the PNMF-PSCC method utilizes the Poisson distribution as the prior knowledge of spectral signals to better explain the quantum nature of light in imaging spectrometer. Third, the optimization problem of PNMF-PSCC is formulated into maximizing the joint density via the Maximum A Posterior (MAP) estimator. The program is finally solved by iteratively optimizing two sub-problems via the Alternating Direction Method of Multipliers (ADMM) framework and the FURTHESTSUM initialization scheme. Five state-of-the art methods are implemented to make comparisons with the performance of PNMF-PSCC on both the synthetic and real HSI datasets. Experimental results show that the PNMF-PSCC outperforms all the five methods in Spectral Angle Distance (SAD) and Root-Mean-Square-Error (RMSE), and especially it could identify good endmembers for ground objects with smaller spectrum divergences.

  6. Constraints on the depth and geometry of the magma chamber of the Olympus Mons Volcano, Mars

    NASA Technical Reports Server (NTRS)

    Zuber, Maria T.; Mouginis-Mark, Peter J.

    1990-01-01

    The summit caldera of the Olympus Mons volcano exhibits one of the clearest examples of tectonic processes associated with shield volcanism on Mars. The radial distance from the center of the transition from concentric ridges to concentric graben within the oldest crater provides a constraint on the geometry and depth of the subsurface magmatic reservoir at the time of subsidence. Here, researchers use this constraint to investigate the size, shape, and depth of the reservoir. Their approach consists of calculating radial surface stresses corresponding to the range of subsurface pressure distributions representing an evacuating magma chamber. They then compare stress patterns to the observed radial positions of concentric ridges and graben. The problem is solved by employing the finite element approach using the program TECTON.

  7. Distance measurements from supernovae and dark energy constraints

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang Yun

    2009-12-15

    Constraints on dark energy from current observational data are sensitive to how distances are measured from Type Ia supernova (SN Ia) data. We find that flux averaging of SNe Ia can be used to test the presence of unknown systematic uncertainties, and yield more robust distance measurements from SNe Ia. We have applied this approach to the nearby+SDSS+ESSENCE+SNLS+HST set of 288 SNe Ia, and the 'Constitution' set of 397 SNe Ia. Combining the SN Ia data with cosmic microwave background anisotropy data from Wilkinson Microwave Anisotropy Probe 5 yr observations, the Sloan Digital Sky Survey baryon acoustic oscillation measurements, themore » data of 69 gamma-ray bursts (GRBs) , and the Hubble constant measurement from the Hubble Space Telescope project SHOES, we measure the dark energy density function X(z){identical_to}{rho}{sub X}(z)/{rho}{sub X}(0) as a free function of redshift (assumed to be a constant at z>1 or z>1.5). Without the flux averaging of SNe Ia, the combined data using the Constitution set of SNe Ia seem to indicate a deviation from a cosmological constant at {approx}95% confidence level at 0 < or apporx. z < or approx. 0.8; they are consistent with a cosmological constant at {approx}68% confidence level when SNe Ia are flux averaged. The combined data using the nearby+SDSS+ESSENCE+SNLS+HST data set of SNe Ia are consistent with a cosmological constant at 68% confidence level with or without flux averaging of SNe Ia, and give dark energy constraints that are significantly more stringent than that using the Constitution set of SNe Ia. Assuming a flat Universe, dark energy is detected at >98% confidence level for z{<=}0.75 using the combined data with 288 SNe Ia from nearby+SDSS+ESSENCE+SNLS+HST, independent of the assumptions about X(z{>=}1). We quantify dark energy constraints without assuming a flat Universe using the dark energy figure of merit for both X(z) and a dark energy equation-of-state linear in the cosmic scale factor.« less

  8. A Spatially-Explicit Modeling Approach to Examine the Interaction of Reproductive Traits and Landscape Characteristics on Arctic Shrub Expansion

    NASA Astrophysics Data System (ADS)

    Naito, A. T.; Cairns, D. M.; Feldman, R. M.; Grant, W. E.

    2014-12-01

    Shrub expansion is one of the most recognized components of terrestrial Arctic change. While experimental work has provided valuable insights into its fine-scale drivers and implications, the contribution of shrub reproductive characteristics to their spatial patterns is poorly understood at broader scales. Building upon our previous work in river valleys in northern Alaska, we developed a C#-based spatially-explicit model that simulates historic landscape-scale shrub establishment between the 1970s and the late 2000s on a yearly time-step while accounting for parameters relating to different reproduction modes (clonal development with and without the "mass effect" and short-distance dispersal), as well as the presence and absence of the interaction of hydrologic constraints using the topographic wetness index. We examined these treatments on floodplains, valley slopes, and interfluves in the Ayiyak, Colville, and Kurupa River valleys. After simulating 30 landscape realizations using each parameter combination, we quantified the spatial characteristics (patch density, edge density, patch size variability, area-weighted shape index, area-weighted fractal dimension index, and mean distance between patches) of the resulting shrub patches on the simulation end date using FRAGSTATS. We used Principal Components Analysis to determine which treatments produced spatial characteristics most similar to those observed in the late 2000s. Based upon our results, we hypothesize that historic shrub expansion in northern Alaska has been driven in part by clonal reproduction with the "mass effect" or short-distance dispersal (< 5 m). The interactive effect of hydrologic characteristics, however, is less clear. These hypotheses may then be tested in future work involving field observations. Given the potential that climate change may facilitate a shift from a clonal to a sexual reproductive strategy, this model may facilitate predictions regarding future Arctic vegetation patterns.

  9. Including Overweight or Obese Students in Physical Education: A Social Ecological Constraint Model

    ERIC Educational Resources Information Center

    Li, Weidong; Rukavina, Paul

    2012-01-01

    In this review, we propose a social ecological constraint model to study inclusion of overweight or obese students in physical education by integrating key concepts and assumptions from ecological constraint theory in motor development and social ecological models in health promotion and behavior. The social ecological constraint model proposes…

  10. Model-based multiple patterning layout decomposition

    NASA Astrophysics Data System (ADS)

    Guo, Daifeng; Tian, Haitong; Du, Yuelin; Wong, Martin D. F.

    2015-10-01

    As one of the most promising next generation lithography technologies, multiple patterning lithography (MPL) plays an important role in the attempts to keep in pace with 10 nm technology node and beyond. With feature size keeps shrinking, it has become impossible to print dense layouts within one single exposure. As a result, MPL such as double patterning lithography (DPL) and triple patterning lithography (TPL) has been widely adopted. There is a large volume of literature on DPL/TPL layout decomposition, and the current approach is to formulate the problem as a classical graph-coloring problem: Layout features (polygons) are represented by vertices in a graph G and there is an edge between two vertices if and only if the distance between the two corresponding features are less than a minimum distance threshold value dmin. The problem is to color the vertices of G using k colors (k = 2 for DPL, k = 3 for TPL) such that no two vertices connected by an edge are given the same color. This is a rule-based approach, which impose a geometric distance as a minimum constraint to simply decompose polygons within the distance into different masks. It is not desired in practice because this criteria cannot completely capture the behavior of the optics. For example, it lacks of sufficient information such as the optical source characteristics and the effects between the polygons outside the minimum distance. To remedy the deficiency, a model-based layout decomposition approach to make the decomposition criteria base on simulation results was first introduced at SPIE 2013.1 However, the algorithm1 is based on simplified assumption on the optical simulation model and therefore its usage on real layouts is limited. Recently AMSL2 also proposed a model-based approach to layout decomposition by iteratively simulating the layout, which requires excessive computational resource and may lead to sub-optimal solutions. The approach2 also potentially generates too many stiches. In this paper, we propose a model-based MPL layout decomposition method using a pre-simulated library of frequent layout patterns. Instead of using the graph G in the standard graph-coloring formulation, we build an expanded graph H where each vertex represents a group of adjacent features together with a coloring solution. By utilizing the library and running sophisticated graph algorithms on H, our approach can obtain optimal decomposition results efficiently. Our model-based solution can achieve a practical mask design which significantly improves the lithography quality on the wafer compared to the rule based decomposition.

  11. Generalized framework for testing gravity with gravitational-wave propagation. II. Constraints on Horndeski theory

    NASA Astrophysics Data System (ADS)

    Arai, Shun; Nishizawa, Atsushi

    2018-05-01

    Gravitational waves (GW) are generally affected by modification of a gravity theory during propagation at cosmological distances. We numerically perform a quantitative analysis on Horndeski theory at the cosmological scale to constrain the Horndeski theory by GW observations in a model-independent way. We formulate a parametrization for a numerical simulation based on the Monte Carlo method and obtain the classification of the models that agrees with cosmic accelerating expansion within observational errors of the Hubble parameter. As a result, we find that a large group of the models in the Horndeski theory that mimic cosmic expansion of the Λ CDM model can be excluded from the simultaneous detection of a GW and its electromagnetic transient counterpart. Based on our result and the latest detection of GW170817 and GRB170817A, we conclude that the subclass of Horndeski theory including arbitrary functions G4 and G5 can hardly explain cosmic accelerating expansion without fine-tuning.

  12. The Origin of Stellar Species: constraining stellar evolution scenarios with Local Group galaxy surveys

    NASA Astrophysics Data System (ADS)

    Sarbadhicary, Sumit; Badenes, Carles; Chomiuk, Laura; Maldonado, Jessica; Caprioli, Damiano; Heger, Mairead; Huizenga, Daniel

    2018-01-01

    Our understanding of the progenitors of many stellar species, such as supernovae, massive and low-mass He-burning stars, is limited because of many poorly constrained aspects of stellar evolution theory. For my dissertation, I have focused on using Local Group galaxy surveys to constrain stellar evolution scenarios by measuring delay-time distributions (DTD). The DTD is the hypothetical occurrence rate of a stellar object per elapsed time after a brief burst of star formation. It is the measured distribution of timescales on which stars evolve, and therefore serves as a powerful observational constraint on theoretical progenitor models. The DTD can be measured from a survey of stellar objects and a set of star-formation histories of the host galaxy, and is particularly effective in the Local Group, where high-quality star-formation histories are available from resolved stellar populations. I am currently calculating a SN DTD with supernova remnants (SNRs) in order to provide the strongest constraints on the progenitors of thermonuclear and core-collapse supernovae. However, most SNRs do not have reliable age measurements and their evolution depends on the ambient environment. For this reason, I wrote a radio light curve model of an SNR population to extract the visibility times and rates of supernovae - crucial ingredients for the DTD - from an SNR survey. The model uses observational constraints on the local environments from multi-wavelength surveys, accounts for missing SNRs and employs the latest models of shock-driven particle acceleration. The final calculation of the SN DTD in the Local Group is awaiting completion of a systematic SNR catalog from deep radio-continuum images, now in preparation by a group led by Dr. Laura Chomiuk. I have also calculated DTDs for the LMC population of RR Lyrae and Cepheid variables, which serve as important distance calibrators and stellar population tracers. We find that Cepheids can have delay-times between 10 Myrs - 1 Gyr, while RR Lyrae can have delay-times < 10 Gyrs. These observations cannot be explained by models using mass and metallicity alone. In future projects, I will apply the DTD technique to constrain the supergiant and pre-supernova evolutionary models.

  13. Seismic structures in the inner and outer core constrained by the PKP observations near the caustic distance range

    NASA Astrophysics Data System (ADS)

    Yu, W.; Wen, L.; Niu, F.

    2002-05-01

    We have extensively collected PKP waveforms around the PKP caustic distance range (141o - 147o) recorded in several dense regional arrays and the Global Seismic Network covering from 1990 to 2000. PKP observations at this distance range (141o - 147o) are usually purposely avoided in travel time analyses, because of the interference of various PKP branches. The observations there, however, will be extremely useful for constraining the seismic structures at both the top of the inner core and the bottom of the outer core. Moreover, because PKIKP phases sample a depth range of 100 km - 170 km below the inner-core boundary at this distant range, their observations fill the sampling depth gap between the PKiKP-PKIKP observations at the smaller distances and the PKPbc-PKIKP phases at the larger distances. Before the PKP caustics (141o - 145o), the diffracted PKP phases near the B caustics (PKPBdiff) and PKiKP phases are discernible in the long-period seismograms, and their differential travel times and waveforms could be used to constrain seismic structures at the bottom of the outer core and/or at the base of the mantle. The observed long-period PKiKP-PKPBdiff waveforms exhibit a hemispheric difference between those sampling the "eastern" and "western" hemispheres, with those sampling the "western" hemisphere showing larger time separations between the two phases. These observations can be explained by models with P velocity gradients of 0.0806 (km/s)/ 200 km for the "western" hemisphere and 0.114 (km/s)/200 km for the "eastern" hemisphere at the bottom of the outer core. Alternatively, these observations can also be explained by models with different velocity structures at the bottom 200 km of the mantle with P velocity variations in an order of 3 percent with respect to PREM. Broadband PKP observations after the PKP caustics (145o - 147o), on the other hand, provide high-quality constraints on the seismic structures at both the top of the inner core and the bottom of the outer core, as PKPbc phases can be used as excellent reference phases. We explore seismic models in both the bottom of the outer core and the top of the inner core, which can consistently explain the seismic observations at the caustic distance range (141o - 147o) and the PKiKP-PKIKP observations at the closer distances (Niu and Wen, Nature, 410, 1081-1084, 2001, Wen and Niu, JGR, submitted).

  14. Structural organization of G-protein-coupled receptors

    NASA Astrophysics Data System (ADS)

    Lomize, Andrei L.; Pogozheva, Irina D.; Mosberg, Henry I.

    1999-07-01

    Atomic-resolution structures of the transmembrane 7-α-helical domains of 26 G-protein-coupled receptors (GPCRs) (including opsins, cationic amine, melatonin, purine, chemokine, opioid, and glycoprotein hormone receptors and two related proteins, retinochrome and Duffy erythrocyte antigen) were calculated by distance geometry using interhelical hydrogen bonds formed by various proteins from the family and collectively applied as distance constraints, as described previously [Pogozheva et al., Biophys. J., 70 (1997) 1963]. The main structural features of the calculated GPCR models are described and illustrated by examples. Some of the features reflect physical interactions that are responsible for the structural stability of the transmembrane α-bundle: the formation of extensive networks of interhelical H-bonds and sulfur-aromatic clusters that are spatially organized as 'polarity gradients' the close packing of side-chains throughout the transmembrane domain; and the formation of interhelical disulfide bonds in some receptors and a plausible Zn2+ binding center in retinochrome. Other features of the models are related to biological function and evolution of GPCRs: the formation of a common 'minicore' of 43 evolutionarily conserved residues; a multitude of correlated replacements throughout the transmembrane domain; an Na+-binding site in some receptors, and excellent complementarity of receptor binding pockets to many structurally dissimilar, conformationally constrained ligands, such as retinal, cyclic opioid peptides, and cationic amine ligands. The calculated models are in good agreement with numerous experimental data.

  15. Precambrian Surface Temperatures and Molecular Phylogeny

    NASA Astrophysics Data System (ADS)

    Schwartzman, David; Lineweaver, Charles H.

    2004-06-01

    The timing of emergence of major organismal groups is consistent with the climatic temperature being equal to their upper temperature limit of growth (T_{max}), implying a temperature constraint on the evolution of each group, with the climatic temperature inferred from the oxygen isotope record of marine cherts. Support for this constraint comes from the correlation of T_{max} with the rRNA molecular phylogenetic distance from the last common ancestor (LCA) for both thermophilic Archaea and Bacteria. In particular, this correlation for hyperthermophilic Archaea suggests a climatic temperature of about 120°C at the time of the LCA, likely in the Hadean.

  16. Value, Cost, and Sharing: Open Issues in Constrained Clustering

    NASA Technical Reports Server (NTRS)

    Wagstaff, Kiri L.

    2006-01-01

    Clustering is an important tool for data mining, since it can identify major patterns or trends without any supervision (labeled data). Over the past five years, semi-supervised (constrained) clustering methods have become very popular. These methods began with incorporating pairwise constraints and have developed into more general methods that can learn appropriate distance metrics. However, several important open questions have arisen about which constraints are most useful, how they can be actively acquired, and when and how they should be propagated to neighboring points. This position paper describes these open questions and suggests future directions for constrained clustering research.

  17. H0LiCOW - V. New COSMOGRAIL time delays of HE 0435-1223: H0 to 3.8 per cent precision from strong lensing in a flat ΛCDM model

    NASA Astrophysics Data System (ADS)

    Bonvin, V.; Courbin, F.; Suyu, S. H.; Marshall, P. J.; Rusu, C. E.; Sluse, D.; Tewes, M.; Wong, K. C.; Collett, T.; Fassnacht, C. D.; Treu, T.; Auger, M. W.; Hilbert, S.; Koopmans, L. V. E.; Meylan, G.; Rumbaugh, N.; Sonnenfeld, A.; Spiniello, C.

    2017-03-01

    We present a new measurement of the Hubble Constant H0 and other cosmological parameters based on the joint analysis of three multiply imaged quasar systems with measured gravitational time delays. First, we measure the time delay of HE 0435-1223 from 13-yr light curves obtained as part of the COSMOGRAIL project. Companion papers detail the modelling of the main deflectors and line-of-sight effects, and how these data are combined to determine the time-delay distance of HE 0435-1223. Crucially, the measurements are carried out blindly with respect to cosmological parameters in order to avoid confirmation bias. We then combine the time-delay distance of HE 0435-1223 with previous measurements from systems B1608+656 and RXJ1131-1231 to create a Time Delay Strong Lensing probe (TDSL). In flat Λ cold dark matter (ΛCDM) with free matter and energy density, we find H0 =71.9^{+2.4}_{-3.0} {km s^{-1} Mpc^{-1}} and Ω _{Λ }=0.62^{+0.24}_{-0.35}. This measurement is completely independent of, and in agreement with, the local distance ladder measurements of H0. We explore more general cosmological models combining TDSL with other probes, illustrating its power to break degeneracies inherent to other methods. The joint constraints from TDSL and Planck are H0 = 69.2_{-2.2}^{+1.4} {km s^{-1} Mpc^{-1}}, Ω _{Λ }=0.70_{-0.01}^{+0.01} and Ω _k=0.003_{-0.006}^{+0.004} in open ΛCDM and H0 =79.0_{-4.2}^{+4.4} {km s^{-1} Mpc^{-1}}, Ω _de=0.77_{-0.03}^{+0.02} and w=-1.38_{-0.16}^{+0.14} in flat wCDM. In combination with Planck and baryon acoustic oscillation data, when relaxing the constraints on the numbers of relativistic species we find Neff = 3.34_{-0.21}^{+0.21} in NeffΛCDM and when relaxing the total mass of neutrinos we find Σmν ≤ 0.182 eV in mνΛCDM. Finally, in an open wCDM in combination with Planck and cosmic microwave background lensing, we find H0 =77.9_{-4.2}^{+5.0} {km s^{-1} Mpc^{-1}}, Ω _de=0.77_{-0.03}^{+0.03}, Ω _k=-0.003_{-0.004}^{+0.004} and w=-1.37_{-0.23}^{+0.18}.

  18. Functional Sites Induce Long-Range Evolutionary Constraints in Enzymes

    PubMed Central

    Jack, Benjamin R.; Meyer, Austin G.; Echave, Julian; Wilke, Claus O.

    2016-01-01

    Functional residues in proteins tend to be highly conserved over evolutionary time. However, to what extent functional sites impose evolutionary constraints on nearby or even more distant residues is not known. Here, we report pervasive conservation gradients toward catalytic residues in a dataset of 524 distinct enzymes: evolutionary conservation decreases approximately linearly with increasing distance to the nearest catalytic residue in the protein structure. This trend encompasses, on average, 80% of the residues in any enzyme, and it is independent of known structural constraints on protein evolution such as residue packing or solvent accessibility. Further, the trend exists in both monomeric and multimeric enzymes and irrespective of enzyme size and/or location of the active site in the enzyme structure. By contrast, sites in protein–protein interfaces, unlike catalytic residues, are only weakly conserved and induce only minor rate gradients. In aggregate, these observations show that functional sites, and in particular catalytic residues, induce long-range evolutionary constraints in enzymes. PMID:27138088

  19. Revisiting syntactic development in deaf and hearing children from a dependency approach. Comment on "Dependency distance: a new perspective on syntactic patterns in natural languages" by Haitao Liu et al.

    NASA Astrophysics Data System (ADS)

    Yan, Jingqi

    2017-07-01

    Linguists are always endeavoring to discover universal rules to explain the language phenomena and interrelations [1]. Through a handful of corpus-based studies and a vast body of supporting evidence from psychological experiments, Liu, Xu and Liang [2] arrive at a conclusion on a general tendency toward dependency distance minimization (DDM) and relate this linguistic universal to the constraints of memory. Dependency distance (DD) is hereby introduced as a linguistic property, with quantitative features of frequency, and profound cognitive grounding as well. However, since the authors do not include language development, in this comment, I would like to discuss some future prospects from this perspective.

  20. The Compatibility of Friedmann Cosmological Models with Observed Properties of Gamma-Ray Bursts and a Large Hubble Constant

    NASA Technical Reports Server (NTRS)

    Horack, John M.; Koshut, Thomas M.; Mallozzi, Robert S.; Emslie, A. Gordon; Meegan, Charles A.

    1996-01-01

    The distance scale to cosmic gamma-ray bursts (GRB's) is still uncertain by many orders of magnitude; however, one viable scenario places GRB's at cosmological distances, thereby permitting them to be used as tracers of the cosmological expansion over a significant range of redshifts zeta. Also, several recent measurements of the Hubble constant H(sub 0) appearing in the referred literature report values of 70-80 km/s /Mpc. Although there is significant debate regarding these measurements, we proceed here under the assumption that they are evidence of a large value for H(sub 0). This is done in order to investigate the additional constraints on cosmological models that can be obtained under this hypothesis when combined with the age of the universe and the brightness distribution of cosmological gamma-ray bursts. We show that the range of cosmological models that can be consistent with the GRB brightness distribution, a Hubble constant of 70-80 km/s/Mpc, and a minimum age of the universe of 13-15 Gyr is constrained significantly, largely independent of a wide range of assumptions regarding the evolutionary nature of the burst population. Low-density, Lambda greater than 0 cosmological models with deceleration parameter in the range -1 less than q(sub 0) less than 0 and density parameter sigma(sub 0) in the range approximately equals 0.10-0.25(Omega(sub 0) approximately equals 0.2-0.5) are strongly favored.

  1. Time-Driven Effects on Processing Relative Clauses

    ERIC Educational Resources Information Center

    Schremm, Andrea; Horne, Merle; Roll, Mikael

    2016-01-01

    The present response time study investigated how a hypothesized time-based working memory constraint of 2-3 s affects the resolution of grammatical and semantic dependencies. Congruent and incongruent object relative (OR) and subject relative sentences were read at different presentation rates so that the distance between dependent words was…

  2. E-Learning Development in Higher Education: Maximising Efficiency--Maintaining Quality.

    ERIC Educational Resources Information Center

    Jones, Deborah; Sims, Rod

    Many tertiary institutions in Australia provide support to develop online teaching and learning resources, an environment characterized by demands from students for quality face-to-face and distance education, staff concern over workloads, institutional budgeting constraints and an imperative to use management systems. There also remains a…

  3. National Open University of Nigeria (NOUN): A Historical Perspective and Challenges

    ERIC Educational Resources Information Center

    Ambe-Uva, Terhemba Nom

    2007-01-01

    Distance education has become an important policy option for educational planners in developing countries. In the context of Nigeria, increasing population, growing national demand for education, dwindling financial resources, increasing fiscal constraints, and therefore narrowing of access to education led to the emergence of Open University in…

  4. Global Optimization of Interplanetary Trajectories in the Presence of Realistic Mission Constraints

    NASA Technical Reports Server (NTRS)

    Hinckley, David; Englander, Jacob; Hitt, Darren

    2015-01-01

    Single trial evaluations Trial creation by Phase-wise GA-style or DE-inspired recombination Bin repository structure requires an initialization period Non-exclusionary Kill Distance Population collapse mechanic Main loop Creation Probabilistic switch between GA and DE creation types Locally optimize Submit to repository Repeat.

  5. Illumination and the perception of remote habitat patches by whit footed mice

    Treesearch

    Patrick A. Zollner; Steven L. Lima

    1999-01-01

    Perceptual range, or the distance at which habitat 'patches' can be perceived, constrains an animal's informational window on a given landscape. If such constraints are great, they may limit successful dispersal between distant habitat patches. On dark nights, nocturnal white-footed mice, Peromyscus leucopus, have surprisingly limited...

  6. Mobile Computing: Trends Enabling Virtual Management

    ERIC Educational Resources Information Center

    Kuyatt, Alan E.

    2011-01-01

    The growing power of mobile computing, with its constantly available wireless link to information, creates an opportunity to use innovative ways to work from any location. This technological capability allows companies to remove constraints of physical proximity so that people and enterprises can work together at a distance. Mobile computing is…

  7. Hard and Soft Constraints in Reliability-Based Design Optimization

    NASA Technical Reports Server (NTRS)

    Crespo, L.uis G.; Giesy, Daniel P.; Kenny, Sean P.

    2006-01-01

    This paper proposes a framework for the analysis and design optimization of models subject to parametric uncertainty where design requirements in the form of inequality constraints are present. Emphasis is given to uncertainty models prescribed by norm bounded perturbations from a nominal parameter value and by sets of componentwise bounded uncertain variables. These models, which often arise in engineering problems, allow for a sharp mathematical manipulation. Constraints can be implemented in the hard sense, i.e., constraints must be satisfied for all parameter realizations in the uncertainty model, and in the soft sense, i.e., constraints can be violated by some realizations of the uncertain parameter. In regard to hard constraints, this methodology allows (i) to determine if a hard constraint can be satisfied for a given uncertainty model and constraint structure, (ii) to generate conclusive, formally verifiable reliability assessments that allow for unprejudiced comparisons of competing design alternatives and (iii) to identify the critical combination of uncertain parameters leading to constraint violations. In regard to soft constraints, the methodology allows the designer (i) to use probabilistic uncertainty models, (ii) to calculate upper bounds to the probability of constraint violation, and (iii) to efficiently estimate failure probabilities via a hybrid method. This method integrates the upper bounds, for which closed form expressions are derived, along with conditional sampling. In addition, an l(sub infinity) formulation for the efficient manipulation of hyper-rectangular sets is also proposed.

  8. Combining Amine-Reactive Cross-Linkers and Photo-Reactive Amino Acids for 3D-Structure Analysis of Proteins and Protein Complexes.

    PubMed

    Lössl, Philip; Sinz, Andrea

    2016-01-01

    During the last 15 years, the combination of chemical cross-linking and high-resolution mass spectrometry (MS) has matured into an alternative approach for analyzing 3D-structures of proteins and protein complexes. Using the distance constraints imposed by the cross-links, models of the protein or protein complex under investigation can be created. The majority of cross-linking studies are currently conducted with homobifunctional amine-reactive cross-linkers. We extend this "traditional" cross-linking/MS strategy by adding complementary photo-cross-linking data. For this, the diazirine-containing unnatural amino acids photo-leucine and photo-methionine are incorporated into the proteins and cross-link formation is induced by UV-A irradiation. The advantage of the photo-cross-linking strategy is that it is not restricted to lysine residues and that hydrophobic regions in proteins can be targeted, which is advantageous for investigating membrane proteins. We consider the strategy of combining cross-linkers with orthogonal reactivities and distances to be ideally suited for maximizing the amount of structural information that can be gained from a cross-linking experiment.

  9. Geometric Reasoning for Automated Planning

    NASA Technical Reports Server (NTRS)

    Clement, Bradley J.; Knight, Russell L.; Broderick, Daniel

    2012-01-01

    An important aspect of mission planning for NASA s operation of the International Space Station is the allocation and management of space for supplies and equipment. The Stowage, Configuration Analysis, and Operations Planning teams collaborate to perform the bulk of that planning. A Geometric Reasoning Engine is developed in a way that can be shared by the teams to optimize item placement in the context of crew planning. The ISS crew spends (at the time of this writing) a third or more of their time moving supplies and equipment around. Better logistical support and optimized packing could make a significant impact on operational efficiency of the ISS. Currently, computational geometry and motion planning do not focus specifically on the optimized orientation and placement of 3D objects based on multiple distance and containment preferences and constraints. The software performs reasoning about the manipulation of 3D solid models in order to maximize an objective function based on distance. It optimizes for 3D orientation and placement. Spatial placement optimization is a general problem and can be applied to object packing or asset relocation.

  10. Galaxy clusters, type Ia supernovae and the fine structure constant

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Holanda, R.F.L.; Busti, V.C.; Colaço, L.R.

    2016-08-01

    As is well known, measurements of the Sunyaev-Zeldovich effect can be combined with observations of the X-ray surface brightness of galaxy clusters to estimate the angular diameter distance to these structures. In this paper, we show that this technique depends on the fine structure constant, α. Therefore, if α is a time-dependent quantity, e.g., α = α{sub 0}φ( z ), where φ is a function of redshift, we argue that current data do not provide the real angular diameter distance, D {sub A}( z ), to the cluster, but instead D {sub A}{sup data}( z ) = φ( z ){supmore » 2} D {sub A}( z ). We use this result to derive constraints on a possible variation of α for a class of dilaton runaway models considering a sample of 25 measurements of D {sub A}{sup data}( z ) in redshift range 0.023 < z < 0.784 and estimates of D {sub A}( z ) from current type Ia supernovae observations. We find no significant indication of variation of α with the present data.« less

  11. Effect of mandibular tori on glottic exposure during simulated suspension microlaryngoscopy.

    PubMed

    Best, Simon R; Kobler, James B; Friedman, Aaron D; Barbu, Anca M; Zeitels, Steven M; Burns, James A

    2014-03-01

    Mandibular tori have been identified as a contributing factor in difficult exposure during intubation. However, no investigation has measured the effect of mandibular tori on glottic exposure during suspension microlaryngoscopy (SML). The objective of this study was to measure how the size and location of mandibular tori affect glottic exposure during simulated SML at different thyromental distances. Suspension microlaryngoscopy was modeled on an anatomically accurate skull and larynx with thyromental distances between 6 and 12 cm. Mandibular tori were simulated by protruding screws 5 to 15 mm from the lingual aspect of the mandible. The tori were positioned either 15 mm (anterior) or 25 mm (posterior) from the midline of the symphysis. The glottic exposure for the various-size tori in each location was measured by recording the displacement of the glottiscope tip relative to the most anterior exposure achievable without tori. The glottiscope angle relative to the horizontal plane was measured for each condition. Mandibular tori of more than 10 mm had a significant impact on glottic exposure. Displacement of the glottiscope tip ranged from 2 to 9 mm for anteriorly placed tori and from 7 to 29 mm for posteriorly placed tori, with larger tori causing greater displacement. Increasing the thyromental distance increased the posterior glottiscope tip displacement regardless of torus size or location. The glottiscope angle increased with larger tori (12º to 28º), but this angle did not change with increasing thyromental distance. Larger size and more-posterior location of mandibular tori more significantly reduce glottic exposure during SML. The inner table of the mandible is the most relevant anatomic constraint on glottic exposure, which varies with the presence or absence of mandibular tori independent of thyromental distance.

  12. Nonlinear Model Predictive Control with Constraint Satisfactions for a Quadcopter

    NASA Astrophysics Data System (ADS)

    Wang, Ye; Ramirez-Jaime, Andres; Xu, Feng; Puig, Vicenç

    2017-01-01

    This paper presents a nonlinear model predictive control (NMPC) strategy combined with constraint satisfactions for a quadcopter. The full dynamics of the quadcopter describing the attitude and position are nonlinear, which are quite sensitive to changes of inputs and disturbances. By means of constraint satisfactions, partial nonlinearities and modeling errors of the control-oriented model of full dynamics can be transformed into the inequality constraints. Subsequently, the quadcopter can be controlled by an NMPC controller with the updated constraints generated by constraint satisfactions. Finally, the simulation results applied to a quadcopter simulator are provided to show the effectiveness of the proposed strategy.

  13. [Near infrared distance sensing method for Chang'e-3 alpha particle X-ray spectrometer].

    PubMed

    Liang, Xiao-Hua; Wu, Ming-Ye; Wang, Huan-Yu; Peng, Wen-Xi; Zhang, Cheng-Mo; Cui, Xing-Zhu; Wang, Jin-Zhou; Zhang, Jia-Yu; Yang, Jia-Wei; Fan, Rui-Rui; Gao, Min; Liu, Ya-Qing; Zhang, Fei; Dong, Yi-Fan; Guo, Dong-Ya

    2013-05-01

    Alpha particle X-ray spectrometer (APXS) is one of the payloads of Chang'E-3 lunar rover, the scientific objective of which is in-situ observation and off-line analysis of lunar regolith and rock. Distance measurement is one of the important functions for APXS to perform effective detection on the moon. The present paper will first give a brief introduction to APXS, and then analyze the specific requirements and constraints to realize distance measurement, at last present a new near infrared distance sensing algorithm by using the inflection point of response curve. The theoretical analysis and the experiment results verify the feasibility of this algorithm. Although the theoretical analysis shows that this method is not sensitive to the operating temperature and reflectance of the lunar surface, the solar infrared radiant intensity may make photosensor saturation. The solutions are reducing the gain of device and avoiding direct exposure to sun light.

  14. Ground-motion prediction from tremor

    USGS Publications Warehouse

    Baltay, Annemarie S.; Beroza, Gregory C.

    2013-01-01

    The widespread occurrence of tremor, coupled with its frequency content and location, provides an exceptional opportunity to test and improve strong ground-motion attenuation relations for subduction zones. We characterize the amplitude of thousands of individual 5 min tremor events in Cascadia during three episodic tremor and slip events to constrain the distance decay of peak ground acceleration (PGA) and peak ground velocity (PGV). We determine the anelastic attenuation parameter for ground-motion prediction equations (GMPEs) to a distance of 150 km, which is sufficient to place important constraints on ground-motion decay. Tremor PGA and PGV show a distance decay that is similar to subduction-zone-specific GMPEs developed from both data and simulations; however, the massive amount of data present in the tremor observations should allow us to refine distance-amplitude attenuation relationships for use in hazard maps, and to search for regional variations and intrasubduction zone differences in ground-motion attenuation.

  15. Improving time-delay cosmography with spatially resolved kinematics

    NASA Astrophysics Data System (ADS)

    Shajib, Anowar J.; Treu, Tommaso; Agnello, Adriano

    2018-01-01

    Strongly gravitational lensed quasars can be used to measure the so-called time-delay distance DΔt, and thus the Hubble constant H0 and other cosmological parameters. Stellar kinematics of the deflector galaxy play an essential role in this measurement by: (i) helping break the mass-sheet degeneracy; (ii) determining in principle the angular diameter distance Dd to the deflector and thus further improving the cosmological constraints. In this paper we simulate observations of lensed quasars with integral field spectrographs and show that spatially resolved kinematics of the deflector enables further progress by helping break the mass-anisotropy degeneracy. Furthermore, we use our simulations to obtain realistic error estimates with current/upcoming instruments like OSIRIS on Keck and NIRSPEC on the James Webb Space Telescope for both distances (typically ∼6 per cent on DΔt and ∼10 per cent on Dd). We use the error estimates to compute cosmological forecasts for the sample of nine lenses that currently have well-measured time delays and deep Hubble Space Telescope images and for a sample of 40 lenses that is projected to be available in a few years through follow-up of candidates found in ongoing wide field surveys. We find that H0 can be measured with 2 per cent (1 per cent) precision from nine (40) lenses in a flat Λcold dark matter cosmology. We study several other cosmological models beyond the flat Λcold dark matter model and find that time-delay lenses with spatially resolved kinematics can greatly improve the precision of the cosmological parameters measured by cosmic microwave background data.

  16. Dark Matter Halos with VIRUS-P

    NASA Astrophysics Data System (ADS)

    Murphy, Jeremy; Gebhardt, K.

    2010-05-01

    We present new, two-dimensional stellar kinematic data on several of the most massive galaxies in the local universe. These data were taken with the integral field spectrograph, VIRUS-P, and extend to unprecedented radial distances. Once robust stellar kinematics are in hand, we run orbit-based axisymmetric dynamical models in order to constrain the stellar mass-to-light ratio and dark matter halo parameters. We have run a large set of dynamical models on the second rank galaxy in the Virgo cluster, M87, and find clear evidence for a massive dark matter halo. The two-dimensional stellar kinematics for several of our other targets, all first and second rank galaxies, are also presented. Dark matter halos are known to dominate the mass profile of elliptical galaxies somewhere between one to two effective radii, yet due to the low surface brightness at these radial distances, determining stellar dynamics is technologically challenging. To overcome this, constraints on the dark matter halo are often made with planetary nebulae or globular clusters at large radii. However, as results from different groups have returned contradictory results, it remains unclear whether different dynamical tracers always follow the stellar kinematics. Due to VIRUS-P's large field of view and on-sky fiber diameter, we are able to determine stellar kinematics at radial distances that overlap with other dynamical tracers. Understanding what the dynamics of stars, planetary nebula and globular clusters tell us about both the extent of the dark matter halo profile and the formation histories of the largest elliptical galaxies is a primary science driver for this work.

  17. The morphological state space revisited: what do phylogenetic patterns in homoplasy tell us about the number of possible character states?

    PubMed Central

    Hoyal Cuthill, Jennifer F.

    2015-01-01

    Biological variety and major evolutionary transitions suggest that the space of possible morphologies may have varied among lineages and through time. However, most models of phylogenetic character evolution assume that the potential state space is finite. Here, I explore what the morphological state space might be like, by analysing trends in homoplasy (repeated derivation of the same character state). Analyses of ten published character matrices are compared against computer simulations with different state space models: infinite states, finite states, ordered states and an ‘inertial' model, simulating phylogenetic constraints. Of these, only the infinite states model results in evolution without homoplasy, a prediction which is not generally met by real phylogenies. Many authors have interpreted the ubiquity of homoplasy as evidence that the number of evolutionary alternatives is finite. However, homoplasy is also predicted by phylogenetic constraints on the morphological distance that can be traversed between ancestor and descendent. Phylogenetic rarefaction (sub-sampling) shows that finite and inertial state spaces do produce contrasting trends in the distribution of homoplasy. Two clades show trends characteristic of phylogenetic inertia, with decreasing homoplasy (increasing consistency index) as we sub-sample more distantly related taxa. One clade shows increasing homoplasy, suggesting exhaustion of finite states. Different clades may, therefore, show different patterns of character evolution. However, when parsimony uninformative characters are excluded (which may occur without documentation in cladistic studies), it may no longer be possible to distinguish inertial and finite state spaces. Interestingly, inertial models predict that homoplasy should be clustered among comparatively close relatives (parallel evolution), whereas finite state models do not. If morphological evolution is often inertial in nature, then homoplasy (false homology) may primarily occur between close relatives, perhaps being replaced by functional analogy at higher taxonomic scales. PMID:26640650

  18. 3D interactive forward and inversion gravity modelling at different scales: From subduction zone modelling to cavity detection.

    NASA Astrophysics Data System (ADS)

    Götze, Hans-Jürgen; Schmidt, Sabine

    2014-05-01

    Modern geophysical interpretation requires an interdisciplinary approach, particularly when considering the available amount of 'state of the art' information. A combination of different geophysical surveys employing seismic, gravity and EM, together with geological and petrological studies, can provide new insights into the structures and tectonic evolution of the lithosphere, natural deposits and underground cavities. Interdisciplinary interpretation is essential for any numerical modelling of these structures and the processes acting on them Interactive gravity and magnetic modeling can play an important role in the depth imaging workflow of complex projects. The integration of the workflow and the tools is important to meet the needs of today's more interactive and interpretative depth imaging workflows. For the integration of gravity and magnetic models the software IGMAS+ can play an important role in this workflow. For simplicity the focus is on gravity modeling, but all methods can be applied to the modeling of magnetic data as well. Currently there are three common ways to define a 3D gravity model. Grid based models: Grids define the different geological units. The densities of the geological units are constant. Additional grids can be introduced to subdivide the geological units, making it possible to represent density depth relations. Polyhedral models: The interfaces between different geological units are defined by polyhedral, typically triangles. Voxel models: Each voxel in a regular cube has a density assigned. Spherical Earth modeling: Geophysical investigations may cover huge areas of several thousand square kilometers. The depression of the earth's surface due to the curvature of the Earth is 3 km at a distance of 200 km and 20 km at a distance of 500 km. Interactive inversion: Inversion is typically done in batch where constraints are defined beforehand and then after a few minutes or hours a model fitting the data and constraints is generated. As examples I show results from the Central Andes and the North Sea. Both gravity and geoid of the two areas were investigated with regard to their isostatic state, the crustal density structure and rigidity of the Lithosphere. Modern satellite measurements of the recent ESA campaigns are compared to ground observations in the region. Estimates of stress and GPE (gravitational potential energy) at the western South American margin have been derived from an existing 3D density model. Here, sensitivity studies of gravity and gravity gradients indicate that short wavelength lithospheric structures are more pronounced in the gravity gradient tensor than in the gravity field. A medium size example of the North Sea underground demonstrates how interdisciplinary data sets can support aero gravity investigations. At the micro scale an example from the detection of a crypt (Alversdorf, Northern Germany) is shown.

  19. The sagittarius tidal stream and the shape of the galactic stellar halo

    NASA Astrophysics Data System (ADS)

    Newby, Matthew T.

    The stellar halo that surrounds our Galaxy contains clues to understanding galaxy formation, cosmology, stellar evolution, and the nature of dark matter. Gravitationally disrupted dwarf galaxies form tidal streams, which roughly trace orbits through the Galactic halo. The Sagittarius (Sgr) dwarf tidal debris is the most dominant of these streams, and its properties place important constraints on the distribution of mass (including dark matter) in the Galaxy. Stars not associated with substructures form the "smooth" component of the stellar halo, the origin of which is still under investigation. Characterizing halo substructures such as the Sgr stream and the smooth halo provides valuable information on the formation history and evolution of our galaxy, and places constraints on cosmological models. This thesis is primarily concerned with characterizing the 3-dimensional stellar densities of the Sgr tidal debris system and the smooth stellar halo, using data from the Sloan Digital Sky Survey (SDSS). F turnoff stars are used to infer distances, as they are relatively bright, numerous, and distributed about a single intrinsic brightness (magnitude). The inherent spread in brightnesses of these stars is overcome through the use of the recently-developed technique of statistical photometric parallax, in which the bulk properties of a stellar population are used to create a probability distribution for a given star's distance. This was used to build a spatial density model for the smooth stellar halo and tidal streams. The free parameters in this model are then fit to SDSS data with a maximum likelihood technique, and the parameters are optimized by advanced computational methods. Several computing platforms are used in this study, including the RPI SUR Bluegene and the Milkyway home volunteer computing project. Fits to the Sgr stream in 18 SDSS data stripes were performed, and a continuous density profile is found for the major Sgr stream. The stellar halo is found to be strongly oblate (flattening parameter q=0.53). A catalog of stars consistent with this density profile is produced as a template for matching future disruption models. The results of this analysis favor a description of the Sgr debris system that includes more than one dwarf galaxy progenitor, with the major streams above and below the Galactic disk being separate substructures. Preliminary results for the minor tidal stream characterizations are presented and discussed. Additionally, a more robust characterization of halo turnoff star brightnesses is performed, and it is found that increasing color errors with distance result in a previously unaccounted for incompleteness in star counts as the SDSS magnitude limit is approached. These corrections are currently in the process of being implemented on MilkyWay home.

  20. GLASS 2.0: An Operational, Multimodal, Bayesian Earthquake Data Association Engine

    NASA Astrophysics Data System (ADS)

    Benz, H.; Johnson, C. E.; Patton, J. M.; McMahon, N. D.; Earle, P. S.

    2015-12-01

    The legacy approach to automated detection and determination of hypocenters is arrival time stacking algorithms. Examples of such algorithms are the associator, Binder, which has been in continuous use in many USGS-supported regional seismic networks since the 1980s and the spherical earth successor, GLASS 1.0, currently in service at the USGS National Earthquake Information Center for over 10 years. The principle short-comings of the legacy approach are 1) it can only use phase arrival times, 2) it does not adequately address the problems of extreme variations in station density worldwide, 3) it cannot incorporate multiple phase models or statistical attributes of phases with distance, and 4) it cannot incorporate noise model attributes of individual stations. Previously we introduced a theoretical framework of a new associator using a Bayesian kernel stacking approach to approximate a joint probability density function for hypocenter localization. More recently we added station- and phase-specific Bayesian constraints to the association process. GLASS 2.0 incorporates a multiplicity of earthquake related data including phase arrival times, back-azimuth and slowness information from array beamforming, arrival times from waveform cross correlation processing, and geographic constraints from real-time social media reports of ground shaking. We demonstrate its application by modeling an aftershock sequence using dozens of stations that recorded tens of thousands of earthquakes over a period of one month. We also demonstrate Glass 2.0 performance regionally and teleseismically using the globally distributed real-time monitoring system at NEIC.

  1. Model-based control strategies for systems with constraints of the program type

    NASA Astrophysics Data System (ADS)

    Jarzębowska, Elżbieta

    2006-08-01

    The paper presents a model-based tracking control strategy for constrained mechanical systems. Constraints we consider can be material and non-material ones referred to as program constraints. The program constraint equations represent tasks put upon system motions and they can be differential equations of orders higher than one or two, and be non-integrable. The tracking control strategy relies upon two dynamic models: a reference model, which is a dynamic model of a system with arbitrary order differential constraints and a dynamic control model. The reference model serves as a motion planner, which generates inputs to the dynamic control model. It is based upon a generalized program motion equations (GPME) method. The method enables to combine material and program constraints and merge them both into the motion equations. Lagrange's equations with multipliers are the peculiar case of the GPME, since they can be applied to systems with constraints of first orders. Our tracking strategy referred to as a model reference program motion tracking control strategy enables tracking of any program motion predefined by the program constraints. It extends the "trajectory tracking" to the "program motion tracking". We also demonstrate that our tracking strategy can be extended to a hybrid program motion/force tracking.

  2. Coding for Communication Channels with Dead-Time Constraints

    NASA Technical Reports Server (NTRS)

    Moision, Bruce; Hamkins, Jon

    2004-01-01

    Coding schemes have been designed and investigated specifically for optical and electronic data-communication channels in which information is conveyed via pulse-position modulation (PPM) subject to dead-time constraints. These schemes involve the use of error-correcting codes concatenated with codes denoted constrained codes. These codes are decoded using an interactive method. In pulse-position modulation, time is partitioned into frames of Mslots of equal duration. Each frame contains one pulsed slot (all others are non-pulsed). For a given channel, the dead-time constraints are defined as a maximum and a minimum on the allowable time between pulses. For example, if a Q-switched laser is used to transmit the pulses, then the minimum allowable dead time is the time needed to recharge the laser for the next pulse. In the case of bits recorded on a magnetic medium, the minimum allowable time between pulses depends on the recording/playback speed and the minimum distance between pulses needed to prevent interference between adjacent bits during readout. The maximum allowable dead time for a given channel is the maximum time for which it is possible to satisfy the requirement to synchronize slots. In mathematical shorthand, the dead-time constraints for a given channel are represented by the pair of integers (d,k), where d is the minimum allowable number of zeroes between ones and k is the maximum allowable number of zeroes between ones. A system of the type to which the present schemes apply is represented by a binary- input, real-valued-output channel model illustrated in the figure. At the transmitting end, information bits are first encoded by use of an error-correcting code, then further encoded by use of a constrained code. Several constrained codes for channels subject to constraints of (d,infinity) have been investigated theoretically and computationally. The baseline codes chosen for purposes of comparison were simple PPM codes characterized by M-slot PPM frames separated by d-slot dead times.

  3. 6-DoF Haptic Rendering Using Continuous Collision Detection between Points and Signed Distance Fields.

    PubMed

    Hongyi Xu; Barbic, Jernej

    2017-01-01

    We present an algorithm for fast continuous collision detection between points and signed distance fields, and demonstrate how to robustly use it for 6-DoF haptic rendering of contact between objects with complex geometry. Continuous collision detection is often needed in computer animation, haptics, and virtual reality applications, but has so far only been investigated for polygon (triangular) geometry representations. We demonstrate how to robustly and continuously detect intersections between points and level sets of the signed distance field. We suggest using an octree subdivision of the distance field for fast traversal of distance field cells. We also give a method to resolve continuous collisions between point clouds organized into a tree hierarchy and a signed distance field, enabling rendering of contact between rigid objects with complex geometry. We investigate and compare two 6-DoF haptic rendering methods now applicable to point-versus-distance field contact for the first time: continuous integration of penalty forces, and a constraint-based method. An experimental comparison to discrete collision detection demonstrates that the continuous method is more robust and can correctly resolve collisions even under high velocities and during complex contact.

  4. Tidal Streams Near and Far

    NASA Astrophysics Data System (ADS)

    Fardal, Mark A.

    2014-06-01

    The Pandas survey of stars in M31's disk and halo is crisscrossed by numerous tidal features from both M31 and the Milky Way. Here I focus on two narrow stellar streams visible in the survey. They have comparable angular extent in the survey (10-13 degrees long versus only 0.3 degree wide), but one is a local Milky Way stream at about 30 kpc and one is in M31, roughly 25 times more distant. I estimate the stellar mass and metallicity in the streams and the distance gradient along them. The kinematics of the M31 stream is sparsely sampled by red giant stars and globular clusters. Bayesian modeling of the stream data yields accurate constraints on the orbital parameters of the streams.

  5. Optimal motion planning for collision avoidance of mobile robots in non-stationary environments

    NASA Technical Reports Server (NTRS)

    Kyriakopoulos, K. J.; Saridis, G. N.

    1992-01-01

    An optimal control formulation of the problem of collision avoidance of mobile robots moving in general terrains containing moving obstacles is presented. A dynamic model of the mobile robot and the dynamic constraints are derived. Collision avoidance is guaranteed if the minimum distance between the robot and the object is nonzero. A nominal trajectory is assumed to be known from off-line planning. The main idea is to change the velocity along the nominal trajectory so that collisions are avoided. Time consistency with the nominal plan is desirable. A numerical solution of the optimization problem is obtained. A perturbation control type of approach is used to update the optimal plan. Simulation results verify the value of the proposed strategy.

  6. Fermi observations of high-energy gamma-ray emission from GRB 080916C.

    PubMed

    Abdo, A A; Ackermann, M; Arimoto, M; Asano, K; Atwood, W B; Axelsson, M; Baldini, L; Ballet, J; Band, D L; Barbiellini, G; Baring, M G; Bastieri, D; Battelino, M; Baughman, B M; Bechtol, K; Bellardi, F; Bellazzini, R; Berenji, B; Bhat, P N; Bissaldi, E; Blandford, R D; Bloom, E D; Bogaert, G; Bogart, J R; Bonamente, E; Bonnell, J; Borgland, A W; Bouvier, A; Bregeon, J; Brez, A; Briggs, M S; Brigida, M; Bruel, P; Burnett, T H; Burrows, D; Busetto, G; Caliandro, G A; Cameron, R A; Caraveo, P A; Casandjian, J M; Ceccanti, M; Cecchi, C; Celotti, A; Charles, E; Chekhtman, A; Cheung, C C; Chiang, J; Ciprini, S; Claus, R; Cohen-Tanugi, J; Cominsky, L R; Connaughton, V; Conrad, J; Costamante, L; Cutini, S; Deklotz, M; Dermer, C D; de Angelis, A; de Palma, F; Digel, S W; Dingus, B L; do Couto E Silva, E; Drell, P S; Dubois, R; Dumora, D; Edmonds, Y; Evans, P A; Fabiani, D; Farnier, C; Favuzzi, C; Finke, J; Fishman, G; Focke, W B; Frailis, M; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Gehrels, N; Germani, S; Giebels, B; Giglietto, N; Giommi, P; Giordano, F; Glanzman, T; Godfrey, G; Goldstein, A; Granot, J; Greiner, J; Grenier, I A; Grondin, M-H; Grove, J E; Guillemot, L; Guiriec, S; Haller, G; Hanabata, Y; Harding, A K; Hayashida, M; Hays, E; Hernando Morat, J A; Hoover, A; Hughes, R E; Jóhannesson, G; Johnson, A S; Johnson, R P; Johnson, T J; Johnson, W N; Kamae, T; Katagiri, H; Kataoka, J; Kavelaars, A; Kawai, N; Kelly, H; Kennea, J; Kerr, M; Kippen, R M; Knödlseder, J; Kocevski, D; Kocian, M L; Komin, N; Kouveliotou, C; Kuehn, F; Kuss, M; Lande, J; Landriu, D; Larsson, S; Latronico, L; Lavalley, C; Lee, B; Lee, S-H; Lemoine-Goumard, M; Lichti, G G; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Madejski, G M; Makeev, A; Marangelli, B; Mazziotta, M N; McBreen, S; McEnery, J E; McGlynn, S; Meegan, C; Mészáros, P; Meurer, C; Michelson, P F; Minuti, M; Mirizzi, N; Mitthumsiri, W; Mizuno, T; Moiseev, A A; Monte, C; Monzani, M E; Moretti, E; Morselli, A; Moskalenko, I V; Murgia, S; Nakamori, T; Nelson, D; Nolan, P L; Norris, J P; Nuss, E; Ohno, M; Ohsugi, T; Okumura, A; Omodei, N; Orlando, E; Ormes, J F; Ozaki, M; Paciesas, W S; Paneque, D; Panetta, J H; Parent, D; Pelassa, V; Pepe, M; Perri, M; Pesce-Rollins, M; Petrosian, V; Pinchera, M; Piron, F; Porter, T A; Preece, R; Rainò, S; Ramirez-Ruiz, E; Rando, R; Rapposelli, E; Razzano, M; Razzaque, S; Rea, N; Reimer, A; Reimer, O; Reposeur, T; Reyes, L C; Ritz, S; Rochester, L S; Rodriguez, A Y; Roth, M; Ryde, F; Sadrozinski, H F-W; Sanchez, D; Sander, A; Saz Parkinson, P M; Scargle, J D; Schalk, T L; Segal, K N; Sgrò, C; Shimokawabe, T; Siskind, E J; Smith, D A; Smith, P D; Spandre, G; Spinelli, P; Stamatikos, M; Starck, J-L; Stecker, F W; Steinle, H; Stephens, T E; Strickman, M S; Suson, D J; Tagliaferri, G; Tajima, H; Takahashi, H; Takahashi, T; Tanaka, T; Tenze, A; Thayer, J B; Thayer, J G; Thompson, D J; Tibaldo, L; Torres, D F; Tosti, G; Tramacere, A; Turri, M; Tuvi, S; Usher, T L; van der Horst, A J; Vigiani, L; Vilchez, N; Vitale, V; von Kienlin, A; Waite, A P; Williams, D A; Wilson-Hodge, C; Winer, B L; Wood, K S; Wu, X F; Yamazaki, R; Ylinen, T; Ziegler, M

    2009-03-27

    Gamma-ray bursts (GRBs) are highly energetic explosions signaling the death of massive stars in distant galaxies. The Gamma-ray Burst Monitor and Large Area Telescope onboard the Fermi Observatory together record GRBs over a broad energy range spanning about 7 decades of gammaray energy. In September 2008, Fermi observed the exceptionally luminous GRB 080916C, with the largest apparent energy release yet measured. The high-energy gamma rays are observed to start later and persist longer than the lower energy photons. A simple spectral form fits the entire GRB spectrum, providing strong constraints on emission models. The known distance of the burst enables placing lower limits on the bulk Lorentz factor of the outflow and on the quantum gravity mass.

  7. Synchrony, Waves, and Spatial Hierarchies in the Spread of Influenza

    NASA Astrophysics Data System (ADS)

    Viboud, Cécile; Bjørnstad, Ottar N.; Smith, David L.; Simonsen, Lone; Miller, Mark A.; Grenfell, Bryan T.

    2006-04-01

    Quantifying long-range dissemination of infectious diseases is a key issue in their dynamics and control. Here, we use influenza-related mortality data to analyze the between-state progression of interpandemic influenza in the United States over the past 30 years. Outbreaks show hierarchical spatial spread evidenced by higher pairwise synchrony between more populous states. Seasons with higher influenza mortality are associated with higher disease transmission and more rapid spread than are mild ones. The regional spread of infection correlates more closely with rates of movement of people to and from their workplaces (workflows) than with geographical distance. Workflows are described in turn by a gravity model, with a rapid decay of commuting up to around 100 km and a long tail of rare longer range flow. A simple epidemiological model, based on the gravity formulation, captures the observed increase of influenza spatial synchrony with transmissibility; high transmission allows influenza to spread rapidly beyond local spatial constraints.

  8. Telescope Scientist on the Advanced X-ray Astrophysics Observatory

    NASA Technical Reports Server (NTRS)

    VanSpeybroeck, L.; Smith, Carl M. (Technical Monitor)

    2002-01-01

    This period included many scientific observations made with the Chandra Observatory. The results, as is well known, are spectacular. Fortunately, the High Resolution Mirror Assembly (HRMA) performance continues to be essentially identical to that predicted from ground calibration data. The Telescope Scientist Team has improved the mirror model to provide a more accurate description to the Chandra observers and enable them to reduce the systematic errors and uncertainties in their data reduction. We also have made considerable progress in improving the scattering model. There also has been progress in the scientific program. At this time 58 distant clusters of galaxies have been observed. We are performing a systematic analysis of this rather large data set for the purpose of determining absolute distances utilizing the Sunyaev Zel'dovich effect. These observations also have been used to study the evolution of the cluster baryon mass function and the cosmological constraints which result from this evolution.

  9. Modeling helical proteins using residual dipolar couplings, sparse long-range distance constraints and a simple residue-based force field

    PubMed Central

    Eggimann, Becky L.; Vostrikov, Vitaly V.; Veglia, Gianluigi; Siepmann, J. Ilja

    2013-01-01

    We present a fast and simple protocol to obtain moderate-resolution backbone structures of helical proteins. This approach utilizes a combination of sparse backbone NMR data (residual dipolar couplings and paramagnetic relaxation enhancements) or EPR data with a residue-based force field and Monte Carlo/simulated annealing protocol to explore the folding energy landscape of helical proteins. By using only backbone NMR data, which are relatively easy to collect and analyze, and strategically placed spin relaxation probes, we show that it is possible to obtain protein structures with correct helical topology and backbone RMS deviations well below 4 Å. This approach offers promising alternatives for the structural determination of proteins in which nuclear Overha-user effect data are difficult or impossible to assign and produces initial models that will speed up the high-resolution structure determination by NMR spectroscopy. PMID:24639619

  10. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pereira, S.H.; Pinho, A.S.S.; Silva, J.M. Hoff da

    In this work the exact Friedmann-Robertson-Walker equations for an Elko spinor field coupled to gravity in an Einstein-Cartan framework are presented. The torsion functions coupling the Elko field spin-connection to gravity can be exactly solved and the FRW equations for the system assume a relatively simple form. In the limit of a slowly varying Elko spinor field there is a relevant contribution to the field equations acting exactly as a time varying cosmological model Λ( t )=Λ{sub *}+3β H {sup 2}, where Λ{sub *} and β are constants. Observational data using distance luminosity from magnitudes of supernovae constraint the parametersmore » Ω {sub m} and β, which leads to a lower limit to the Elko mass. Such model mimics, then, the effects of a dark energy fluid, here sourced by the Elko spinor field. The density perturbations in the linear regime were also studied in the pseudo-Newtonian formalism.« less

  11. The decay overline B to overline K {ell^{ + }}{ell^{ - }} at low hadronic recoil and model-independent ∆ B = 1 constraints

    NASA Astrophysics Data System (ADS)

    Bobeth, Christoph; Hiller, Gudrun; van Dyk, Danny; Wacker, Christian

    2012-01-01

    We study the decay overline B to overline K {ell^{ + }}{ell^{ - }} for ℓ = e, μ, τ with a softly recoiling kaon, that is, for high dilepton invariant masses sqrt {{{q^{{2}}}}} of the order of the b-quark mass. This kinematic region can be treated within an operator product expansion and simplified using heavy quark symmetry, leading to systematic predictions for heavy-to-light processes such as overline B to {overline K^{{left( * right)}}}{ell^{ + }}{ell^{ - }} . We show that the decay rates of both overline B to {overline K^{ * }}{ell^{ + }}{ell^{ - }} and overline B to overline K {ell^{ + }}{ell^{ - }} decays into light leptons depend on a common combination of short-distance coefficients. The corresponding CP-asymmetries are hence identical. Furthermore we present low recoil predictions for overline B to overline K {ell^{ + }}{ell^{ - }} observables, including the flat term in the angular distribution which becomes sizable for taus. We work out model-independently the constraints on Δ B = 1 operators using the most recent data from the experiments BaBar, Belle, CDF and LHCb. For constructive interference with the standard model, generic new physics is pushed up to scales above 44 TeV at 95% CL. Assuming none or small CP-violation we obtain a lower bound on the position of the zero of the forward-backward asymmetry of {overline B^0} to {overline K^{{ * 0}}}{ell^{ + }}{ell^{ - }} decays as q_0^2 > {1}.{7} GeV2, which improves to q_0^2 > 2.6 GeV2 for a standard model-like sign b → sγ amplitude.

  12. CONSTRAINTS FROM ASYMMETRIC HEATING: INVESTIGATING THE EPSILON AURIGAE DISK

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pearson, Richard L. III; Stencel, Robert E., E-mail: richard.pearson@du.edu, E-mail: robert.stencel@du.edu

    2015-01-01

    Epsilon Aurigae is a long-period eclipsing binary that likely contains an F0Ia star and a circumstellar disk enshrouding a hidden companion, assumed to be a main-sequence B star. High uncertainty in its parallax has kept the evolutionary status of the system in question and, hence, the true nature of each component. This unknown, as well as the absence of solid state spectral features in the infrared, requires an investigation of a wide parameter space by means of both analytic and Monte Carlo radiative transfer (MCRT) methods. The first MCRT models of epsilon Aurigae that include all three system components aremore » presented here. We seek additional system parameter constraints by melding analytic approximations with MCRT outputs (e.g., dust temperatures) on a first-order level. The MCRT models investigate the effects of various parameters on the disk-edge temperatures; these include two distances, three particle size distributions, three compositions, and two disk masses, resulting in 36 independent models. Specifically, the MCRT temperatures permit analytic calculations of effective heating and cooling curves along the disk edge. These are used to calculate representative observed fluxes and corresponding temperatures. This novel application of thermal properties provides the basis for utilization of other binary systems containing disks. We find degeneracies in the model fits for the various parameter sets. However, the results show a preference for a carbon disk with particle size distributions ≥10 μm. Additionally, a linear correlation between the MCRT noon and basal temperatures serves as a tool for effectively eliminating portions of the parameter space.« less

  13. De novo establishment of wild-type song culture in the zebra finch

    PubMed Central

    Feher, Olga; Wang, Haibin; Saar, Sigal; Mitra, Partha P.; Tchernichovski, Ofer

    2009-01-01

    What sort of culture would evolve in an island colony of naive founders? This question cannot be studied experimentally in humans. We performed the analogous experiment using socially learned birdsong. Culture is typically viewed as consisting of traits inherited epigenetically, via social learning. However, cultural diversity has species-typical constraints1, presumably of genetic origin. A celebrated, if contentious, example is whether a universal grammar constrains syntactic diversity in human languages2. Oscine songbirds exhibit song learning and provide biologically tractable models of culture: members of a species show individual variation in song3 and geographically separated groups have local song dialects 4,5. Different species exhibit distinct song cultures6,7, suggestive of genetic constraints8,9. Absent such constraints, innovations and copying errors should cause unbounded variation over multiple generations or geographical distance, contrary to observations9. We asked if wild-type song culture might emerge over multiple generations in an isolated colony founded by isolates, and if so, how this might happen and what type of social environment is required10. Zebra finch isolates, unexposed to singing males during development, produce song with characteristics that differ from the wild-type song found in laboratory11 or natural colonies. In tutoring lineages starting from isolate founders, we quantified alterations in song across tutoring generations in two social environments: tutor-pupil pairs in sound-isolated chambers and an isolated semi-natural colony. In both settings, juveniles imitated the isolate tutors, but changed certain characteristics of the songs. These alterations accumulated over learning generations. Consequently, songs evolved toward the wild-type in 3–4 generations. Thus, species-typical song culture can appear de novo. Our study has parallels with language change and evolution12,13. In analogy to models in quantitative genetics14,15, we model song culture as a multi-generational phenotype, partly encoded genetically in an isolate founding population, influenced by environmental variables, and taking multiple generations to emerge. PMID:19412161

  14. Geomagnetic main field modeling using magnetohydrodynamic constraints

    NASA Technical Reports Server (NTRS)

    Estes, R. H.

    1985-01-01

    The influence of physical constraints are investigated which may be approximately satisfied by the Earth's liquid core on models of the geomagnetic main field and its secular variation. A previous report describes the methodology used to incorporate nonlinear equations of constraint into the main field model. The application of that methodology to the GSFC 12/83 field model to test the frozen-flux hypothesis and the usefulness of incorporating magnetohydrodynamic constraints for obtaining improved geomagnetic field models is described.

  15. Global constraints on Z2 fluxes in two different anisotropic limits of a hypernonagon Kitaev model

    NASA Astrophysics Data System (ADS)

    Kato, Yasuyuki; Kamiya, Yoshitomo; Nasu, Joji; Motome, Yukitoshi

    2018-05-01

    The Kitaev model is an exactly-soluble quantum spin model, whose ground state provides a canonical example of a quantum spin liquid. Spin excitations from the ground state are fractionalized into emergent matter fermions and Z2 fluxes. The Z2 flux excitation is pointlike in two dimensions, while it comprises a closed loop in three dimensions because of the local constraint for each closed volume. In addition, the fluxes obey global constraints involving (semi)macroscopic number of fluxes. We here investigate such global constraints in the Kitaev model on a three-dimensional lattice composed of nine-site elementary loops, dubbed the hypernonagon lattice, whose ground state is a chiral spin liquid. We consider two different anisotropic limits of the hypernonagon Kitaev model where the low-energy effective models are described solely by the Z2 fluxes. We show that there are two kinds of global constraints in the model defined on a three-dimensional torus, namely, surface and volume constraints: the surface constraint is imposed on the even-odd parity of the total number of fluxes threading a two-dimensional slice of the system, while the volume constraint is for the even-odd parity of the number of the fluxes through specific plaquettes whose total number is proportional to the system volume. In the two anisotropic limits, therefore, the elementary excitation of Z2 fluxes occurs in a pair of closed loops so as to satisfy both two global constraints as well as the local constraints.

  16. The Systems Biology Markup Language (SBML) Level 3 Package: Flux Balance Constraints.

    PubMed

    Olivier, Brett G; Bergmann, Frank T

    2015-09-04

    Constraint-based modeling is a well established modelling methodology used to analyze and study biological networks on both a medium and genome scale. Due to their large size, genome scale models are typically analysed using constraint-based optimization techniques. One widely used method is Flux Balance Analysis (FBA) which, for example, requires a modelling description to include: the definition of a stoichiometric matrix, an objective function and bounds on the values that fluxes can obtain at steady state. The Flux Balance Constraints (FBC) Package extends SBML Level 3 and provides a standardized format for the encoding, exchange and annotation of constraint-based models. It includes support for modelling concepts such as objective functions, flux bounds and model component annotation that facilitates reaction balancing. The FBC package establishes a base level for the unambiguous exchange of genome-scale, constraint-based models, that can be built upon by the community to meet future needs (e. g. by extending it to cover dynamic FBC models).

  17. The Systems Biology Markup Language (SBML) Level 3 Package: Flux Balance Constraints.

    PubMed

    Olivier, Brett G; Bergmann, Frank T

    2015-06-01

    Constraint-based modeling is a well established modelling methodology used to analyze and study biological networks on both a medium and genome scale. Due to their large size, genome scale models are typically analysed using constraint-based optimization techniques. One widely used method is Flux Balance Analysis (FBA) which, for example, requires a modelling description to include: the definition of a stoichiometric matrix, an objective function and bounds on the values that fluxes can obtain at steady state. The Flux Balance Constraints (FBC) Package extends SBML Level 3 and provides a standardized format for the encoding, exchange and annotation of constraint-based models. It includes support for modelling concepts such as objective functions, flux bounds and model component annotation that facilitates reaction balancing. The FBC package establishes a base level for the unambiguous exchange of genome-scale, constraint-based models, that can be built upon by the community to meet future needs (e. g. by extending it to cover dynamic FBC models).

  18. The Fluence and Distance Distributions of Fast Radio Bursts

    NASA Astrophysics Data System (ADS)

    Vedantham, H. K.; Ravi, V.; Hallinan, G.; Shannon, R. M.

    2016-10-01

    Fast radio bursts (FRB) are millisecond-duration radio pulses with apparent extragalactic origins. All but two of the FRBs have been discovered using the Parkes dish, which employs multiple beams formed by an array of feed horns on its focal plane. In this paper, we show that (I) the preponderance of multiple-beam detections and (II) the detection rates for varying dish diameters can be used to infer the index α of the cumulative fluence distribution function (the logN-logF function: α = 1.5 for a non-evolving population in a Euclidean universe). If all detected FRBs arise from a single progenitor population, multiple-beam FRB detection rates from the Parkes telescope yield the constraint 0.52 < α < 1.0 with 90% confidence. Searches at other facilities with different dish sizes refine the constraint to 0.5 < α < 0.9. Our results favor FRB searches with smaller dishes, because for α < 1 the gain in field of view for a smaller dish is more important than the reduction in sensitivity. Further, our results suggest that (I) FRBs are not standard candles, and (II) the distribution of distances to the detected FRBs is weighted toward larger distances. If FRBs are extragalactic, these results are consistent with a cosmological population, which would make FRBs excellent probes of the baryonic content and geometry of the universe.

  19. 3D shape analysis of the brain's third ventricle using a midplane encoded symmetric template model

    PubMed Central

    Kim, Jaeil; Valdés Hernández, Maria del C.; Royle, Natalie A.; Maniega, Susana Muñoz; Aribisala, Benjamin S.; Gow, Alan J.; Bastin, Mark E.; Deary, Ian J.; Wardlaw, Joanna M.; Park, Jinah

    2016-01-01

    Background Structural changes of the brain's third ventricle have been acknowledged as an indicative measure of the brain atrophy progression in neurodegenerative and endocrinal diseases. To investigate the ventricular enlargement in relation to the atrophy of the surrounding structures, shape analysis is a promising approach. However, there are hurdles in modeling the third ventricle shape. First, it has topological variations across individuals due to the inter-thalamic adhesion. In addition, as an interhemispheric structure, it needs to be aligned to the midsagittal plane to assess its asymmetric and regional deformation. Method To address these issues, we propose a model-based shape assessment. Our template model of the third ventricle consists of a midplane and a symmetric mesh of generic shape. By mapping the template's midplane to the individuals’ brain midsagittal plane, we align the symmetric mesh on the midline of the brain before quantifying the third ventricle shape. To build the vertex-wise correspondence between the individual third ventricle and the template mesh, we employ a minimal-distortion surface deformation framework. In addition, to account for topological variations, we implement geometric constraints guiding the template mesh to have zero width where the inter-thalamic adhesion passes through, preventing vertices crossing between left and right walls of the third ventricle. The individual shapes are compared using a vertex-wise deformity from the symmetric template. Results Experiments on imaging and demographic data from a study of aging showed that our model was sensitive in assessing morphological differences between individuals in relation to brain volume (i.e. proxy for general brain atrophy), gender and the fluid intelligence at age 72. It also revealed that the proposed method can detect the regional and asymmetrical deformation unlike the conventional measures: volume (median 1.95 ml, IQR 0.96 ml) and width of the third ventricle. Similarity measures between binary masks and the shape model showed that the latter reconstructed shape details with high accuracy (Dice coefficient ≥0.9, mean distance 0.5 mm and Hausdorff distance 2.7 mm). Conclusions We have demonstrated that our approach is suitable to morphometrical analyses of the third ventricle, providing high accuracy and inter-subject consistency in the shape quantification. This shape modeling method with geometric constraints based on anatomical landmarks could be extended to other brain structures which require a consistent measurement basis in the morphometry. PMID:27084320

  20. Gold Nanoparticles as a Photothermal Agent in Cancer Therapy: The Thermal Ablation Characteristic Length.

    PubMed

    Grosges, Thomas; Barchiesi, Dominique

    2018-05-31

    In cancer therapy, the thermal ablation of diseased cells by embedded nanoparticles is one of the known therapies. It is based on the absorption of the energy of the illuminating laser by nanoparticles. The resulting heating of nanoparticles kills the cell where these photothermal agents are embedded. One of the main constraints of this therapy is preserving the surrounding healthy cells. Therefore, two parameters are of interest. The first one is the thermal ablation characteristic length, which corresponds to an action distance around the nanoparticles for which the temperature exceeds the ablation threshold. This critical geometric parameter is related to the expected conservation of the body temperature in the surroundings of the diseased cell. The second parameter is the temperature that should be reached to achieve active thermal agents. The temperature depends on the power of the illuminating laser, on the size of nanoparticles and on their physical properties. The purpose of this paper is to propose behavior laws under the constraints of both the body temperature at the boundary of the cell to preserve surrounding cells and an acceptable range of temperature in the target cell. The behavior laws are deduced from the finite element method, which is able to model aggregates of nanoparticles. We deduce sensitivities to the laser power and to the particle size. We show that the tuning of the temperature elevation and of the distance of action of a single nanoparticle is not significantly affected by variations of the particle size and of the laser power. Aggregates of nanoparticles are much more efficient, but represent a potential risk to the surrounding cells. Fortunately, by tuning the laser power, the thermal ablation characteristic length can be controlled.

  1. Stereo transparency and the disparity gradient limit

    NASA Technical Reports Server (NTRS)

    McKee, Suzanne P.; Verghese, Preeti

    2002-01-01

    Several studies (Vision Research 15 (1975) 583; Perception 9 (1980) 671) have shown that binocular fusion is limited by the disparity gradient (disparity/distance) separating image points, rather than by their absolute disparity values. Points separated by a gradient >1 appear diplopic. These results are sometimes interpreted as a constraint on human stereo matching, rather than a constraint on fusion. Here we have used psychophysical measurements on stereo transparency to show that human stereo matching is not constrained by a gradient of 1. We created transparent surfaces composed of many pairs of dots, in which each member of a pair was assigned a disparity equal and opposite to the disparity of the other member. For example, each pair could be composed of one dot with a crossed disparity of 6' and the other with uncrossed disparity of 6', vertically separated by a parametrically varied distance. When the vertical separation between the paired dots was small, the disparity gradient for each pair was very steep. Nevertheless, these opponent-disparity dot pairs produced a striking appearance of two transparent surfaces for disparity gradients ranging between 0.5 and 3. The apparent depth separating the two transparent planes was correctly matched to an equivalent disparity defined by two opaque surfaces. A test target presented between the two transparent planes was easily detected, indicating robust segregation of the disparities associated with the paired dots into two transparent surfaces with few mismatches in the target plane. Our simulations using the Tsai-Victor model show that the response profiles produced by scaled disparity-energy mechanisms can account for many of our results on the transparency generated by steep gradients.

  2. Application of two-dimensional NMR spectroscopy and molecular dynamics simulations to the conformational analysis of oligosaccharides corresponding to the cell-wall polysaccharide of Streptococcus group A.

    PubMed

    Kreis, U C; Varma, V; Pinto, B M

    1995-06-01

    This paper describes the use of a protocol for conformational analysis of oligosaccharide structures related to the cell-wall polysaccharide of Streptococcus group A. The polysaccharide features a branched structure with an L-rhamnopyranose (Rhap) backbone consisting of alternating alpha-(1-->2) and alpha-(1-->3) links and D-N-acetylglucosamine (GlcpNAc) residues beta-(1-->3)-connected to alternating rhamnose rings: [formula: see text] Oligomers consisting of three to six residues have been synthesized and nuclear magnetic resonance (NMR) assignments have been made. The protocol for conformational analysis of the solution structure of these oligosaccharides involves experimental and theoretical methods. Two-dimensional NMR spectroscopy methods (TOCSY, ROESY and NOESY) are utilized to obtain chemical shift data and proton-proton distances. These distances are used as constraints in 100 ps molecular dynamics simulations in water using QUANTA and CHARMm. In addition, the dynamics simulations are performed without constraints. ROE build-up curves are computed from the averaged structures of the molecular dynamics simulations using the CROSREL program and compared with the experimental curves. Thus, a refinement of the initial structure may be obtained. The alpha-(1-->2) and the beta-(1-->3) links are unambiguously defined by the observed ROE cross peaks between the A-B',A'-B and C-B,C'-B' residues, respectively. The branch-point of the trisaccharide CBA' is conformationally well-defined. Assignment of the conformation of the B-A linkage (alpha-(1-->3)) was problematic due to TOCSY relay, but could be solved by NOESY and T-ROESY techniques. A conformational model for the polysaccharide is proposed.

  3. Neutron star mass and radius measurements from atmospheric model fits to X-ray burst cooling tail spectra

    NASA Astrophysics Data System (ADS)

    Nättilä, J.; Miller, M. C.; Steiner, A. W.; Kajava, J. J. E.; Suleimanov, V. F.; Poutanen, J.

    2017-12-01

    Observations of thermonuclear X-ray bursts from accreting neutron stars (NSs) in low-mass X-ray binary systems can be used to constrain NS masses and radii. Most previous work of this type has set these constraints using Planck function fits as a proxy: the models and the data are both fit with diluted blackbody functions to yield normalizations and temperatures that are then compared with each other. For the first time, we here fit atmosphere models of X-ray bursting NSs directly to the observed spectra. We present a hierarchical Bayesian fitting framework that uses current X-ray bursting NS atmosphere models with realistic opacities and relativistic exact Compton scattering kernels as a model for the surface emission. We test our approach against synthetic data and find that for data that are well described by our model, we can obtain robust radius, mass, distance, and composition measurements. We then apply our technique to Rossi X-ray Timing Explorer observations of five hard-state X-ray bursts from 4U 1702-429. Our joint fit to all five bursts shows that the theoretical atmosphere models describe the data well, but there are still some unmodeled features in the spectrum corresponding to a relative error of 1-5% of the energy flux. After marginalizing over this intrinsic scatter, we find that at 68% credibility, the circumferential radius of the NS in 4U 1702-429 is R = 12.4±0.4 km, the gravitational mass is M = 1.9±0.3 M⊙, the distance is 5.1 < D/ kpc < 6.2, and the hydrogen mass fraction is X < 0.09.

  4. Virasoro constraints for D 2n + 1 -, E 6 -, E 7 -, E 8 -type minimal models coupled to 2D gravity

    NASA Astrophysics Data System (ADS)

    Yen, Tim

    1990-12-01

    We find Virasoro constraints for D 2 n + 1 -, E 6 -, E 7 -, E 8 -type models analogous to the recently discovered Virasoro constraints for A n-type models by Fukuma et al., and Dijkgraaf et al. We verify that the proposed Virasoro constraints give operator scaling dimensions identical to those found by Kostov. We check that these Virasoro constraints and, more generally, W-algebra constraints can be used to express correlation functions with non-primary operator in terms of correlation functions of primary operators only.

  5. The origin and evolution of a differentiated Mimas

    NASA Astrophysics Data System (ADS)

    Neveu, M.; Rhoden, A. R.

    2017-11-01

    In stark contrast with its neighbor moon Enceladus, Mimas is surprisingly geologically quiet, despite an eccentric orbit and distance to Saturn prone to levels of tidal dissipation 30 times higher. While Mimas' lack of geological activity could be due to a stiff, frigid interior, libration data acquired using the Cassini spacecraft suggest that its interior is not homogeneous. Here, we present one-dimensional models of the thermal, structural, and orbital evolution of Mimas under two accretion scenarios: primordial, undifferentiated formation in the Saturnian sub-nebula, and late, layered formation from a debris ring created by the disruption of one or more previous moons. We find it difficult to reproduce a differentiated, eccentric Mimas under a primordial accretion scenario: either Mimas never differentiates, or the internal warming that leads to differentiation increases tidal dissipation, yielding runaway heating that produces a persistent ocean, thereby circularizing Mimas' orbit. Only if Mimas accretes very early (so that the decay of short-lived radionuclides initiates differentiation) but its rheology is not highly dissipative (in order to stop runaway tidal heating even if the eccentricity is not negligible) can the simulations match the observational constraints. Alternatively, a late, layered accretion scenario yields a present-day Mimas that matches observational constraints, independently of the magnitude of tidal dissipation. Consistent with previous findings, these models do not produce an ocean on Enceladus unless its orbital eccentricity is higher than today's value.

  6. New constraints on dike injection and fault slip during the 1975-1984 Krafla rift crisis, NE Iceland

    NASA Astrophysics Data System (ADS)

    Hollingsworth, J.; Leprince, Sébastien; Ayoub, François; Avouac, Jean-Philippe

    2013-07-01

    Correlation of KH9 spy and SPOT5 satellite images, airphotos, digital elevation model differencing, electronic distance measurement, and leveling survey data is used to constrain the deformation resulting from the 1975-1984 Krafla rifting crisis. We find that diking typically extends to depths of 5 km, while the dike tops range from 0 km in the caldera region to 3 km at the northern end of the rift. Extension is accommodated by diking at depth and normal faulting in the shallowest crust. In the southern section of the Krafla rift, surface opening is 80% of the dike opening at depth. Over the 70-80 km length of the rift, the average dike opening was 4.3-5.4 m. From these estimates, we calculate the total geodetic moment released over the Krafla rift crisis, 4.4-9.0×1019 Nm, which is an order of magnitude higher than the seismic moment released over the same time period, ~5.8×1018 Nm. The total volume of magma added to the upper crust was 1.1-2.1×109m3. This study highlights how optical image correlation using inexpensive declassified spy satellite and airphotos, combined with simple models of crustal deformation, can provide important constraints on the deformation resulting from past earthquake and volcanic events.

  7. Exact extreme-value statistics at mixed-order transitions.

    PubMed

    Bar, Amir; Majumdar, Satya N; Schehr, Grégory; Mukamel, David

    2016-05-01

    We study extreme-value statistics for spatially extended models exhibiting mixed-order phase transitions (MOT). These are phase transitions that exhibit features common to both first-order (discontinuity of the order parameter) and second-order (diverging correlation length) transitions. We consider here the truncated inverse distance squared Ising model, which is a prototypical model exhibiting MOT, and study analytically the extreme-value statistics of the domain lengths The lengths of the domains are identically distributed random variables except for the global constraint that their sum equals the total system size L. In addition, the number of such domains is also a fluctuating variable, and not fixed. In the paramagnetic phase, we show that the distribution of the largest domain length l_{max} converges, in the large L limit, to a Gumbel distribution. However, at the critical point (for a certain range of parameters) and in the ferromagnetic phase, we show that the fluctuations of l_{max} are governed by novel distributions, which we compute exactly. Our main analytical results are verified by numerical simulations.

  8. Multi-Criteria Optimization of the Deployment of a Grid for Rural Electrification Based on a Heuristic Method

    NASA Astrophysics Data System (ADS)

    Ortiz-Matos, L.; Aguila-Tellez, A.; Hincapié-Reyes, R. C.; González-Sanchez, J. W.

    2017-07-01

    In order to design electrification systems, recent mathematical models solve the problem of location, type of electrification components, and the design of possible distribution microgrids. However, due to the amount of points to be electrified increases, the solution to these models require high computational times, thereby becoming unviable practice models. This study posed a new heuristic method for the electrification of rural areas in order to solve the problem. This heuristic algorithm presents the deployment of rural electrification microgrids in the world, by finding routes for optimal placement lines and transformers in transmission and distribution microgrids. The challenge is to obtain a display with equity in losses, considering the capacity constraints of the devices and topology of the land at minimal economic cost. An optimal scenario ensures the electrification of all neighbourhoods to a minimum investment cost in terms of the distance between electric conductors and the amount of transformation devices.

  9. Constraining parameters of the neutron star in the supernova remnant HESS J1731-347

    NASA Astrophysics Data System (ADS)

    Klochkov, D.; Suleimanov, V.; Puehlhofer, G.; Werner, K.; Santangelo, A.

    2014-07-01

    The Central Compact Object (CCO) in HESS J1731-347, presumably a neutron star, is one of the brightest sources in this class. Like other CCOs, it potentially provides an "undisturbed" view of thermal radiation generated at the neutron star surface. The shape and normalization of the corresponding X-ray spectrum depends on the emitting area, surface redshift, and gravity acceleration. Thus, its modeling under certain assumptions allows the mass and radius of the neutron star to be constrained. In our analysis, we model the spectrum of the CCO accumulated with XMM-Newton over ˜100 ksec exposure time in three observations. The exposure time has increased by a factor of five since our previous analysis of the source. For the spectral fitting, we use our hydrogen and carbon atmosphere models calculated assuming hydrostatic and radiative equilibria and taking into account pressure ionization and the presence of spectral lines (in case of carbon). We present the resulting constraints on the mass, radius, distance, and temperature of the neutron star.

  10. Curvature from Strong Gravitational Lensing: A Spatially Closed Universe or Systematics?

    NASA Astrophysics Data System (ADS)

    Li, Zhengxiang; Ding, Xuheng; Wang, Guo-Jian; Liao, Kai; Zhu, Zong-Hong

    2018-02-01

    Model-independent constraints on the spatial curvature are not only closely related to important problems, such as the evolution of the universe and properties of dark energy, but also provide a test of the validity of the fundamental Copernican principle. In this paper, with the distance sum rule in the Friedmann–Lemaître–Robertson–Walker metric, we achieve model-independent measurements of the spatial curvature from the latest type Ia supernovae and strong gravitational lensing (SGL) observations. We find that a spatially closed universe is preferred. Moreover, by considering different kinds of velocity dispersion and subsamples, we study possible factors that might affect model-independent estimations for the spatial curvature from SGL observations. It is suggested that the combination of observational data from different surveys might cause a systematic bias, and the tension between the spatially flat universe and SGL observations is alleviated when the subsample only from the Sloan Lens ACS Survey is used or a more complex treatment for the density profile of lenses is considered.

  11. RX J1856-3754: Evidence for a Stiff Equation of State

    NASA Astrophysics Data System (ADS)

    Braje, Timothy M.; Romani, Roger W.

    2002-12-01

    We have examined the soft X-ray plus optical/UV spectrum of the nearby isolated neutron star RX J1856-3754, comparing it with detailed models of a thermally emitting surface. Like previous investigators, we find that the spectrum is best fitted by a two-temperature blackbody model. In addition, our simulations constrain the allowed viewing geometry from the observed pulse fraction upper limits. These simulations show that RX J1856-3754 is very likely to be a normal young pulsar, with the nonthermal radio beam missing Earth's line of sight. The spectral energy distribution limits on the model parameter space put a strong constraint on the star's M/R. At the measured parallax distance, the allowed range for MNS=1.5Msolar is RNS=13.7+/-0.6km. Under this interpretation, the equation of state (EOS) is relatively stiff near nuclear density, and the quark star EOS posited in some previous studies is strongly excluded. The data also constrain the surface T distribution over the polar cap.

  12. Combining Multiple Forms Of Visual Information To Specify Contact Relations In Spatial Layout

    NASA Astrophysics Data System (ADS)

    Sedgwick, Hal A.

    1990-03-01

    An expert system, called Layout2, has been described, which models a subset of available visual information for spatial layout. The system is used to examine detailed interactions between multiple, partially redundant forms of information in an environment-centered geometrical model of an environment obeying certain rather general constraints. This paper discusses the extension of Layout2 to include generalized contact relations between surfaces. In an environment-centered model, the representation of viewer-centered distance is replaced by the representation of environmental location. This location information is propagated through the representation of the environment by a network of contact relations between contiguous surfaces. Perspective information interacts with other forms of information to specify these contact relations. The experimental study of human perception of contact relations in extended spatial layouts is also discussed. Differences between human results and Layout2 results reveal limitations in the human ability to register available information; they also point to the existence of certain forms of information not yet formalized in Layout2.

  13. Reduction of shock induced noise in imperfectly expanded supersonic jets using convex optimization

    NASA Astrophysics Data System (ADS)

    Adhikari, Sam

    2007-11-01

    Imperfectly expanded jets generate screech noise. The imbalance between the backpressure and the exit pressure of the imperfectly expanded jets produce shock cells and expansion or compression waves from the nozzle. The instability waves and the shock cells interact to generate the screech sound. The mathematical model consists of cylindrical coordinate based full Navier-Stokes equations and large-eddy-simulation turbulence modeling. Analytical and computational analysis of the three-dimensional helical effects provide a model that relates several parameters with shock cell patterns, screech frequency and distribution of shock generation locations. Convex optimization techniques minimize the shock cell patterns and the instability waves. The objective functions are (convex) quadratic and the constraint functions are affine. In the quadratic optimization programs, minimization of the quadratic functions over a set of polyhedrons provides the optimal result. Various industry standard methods like regression analysis, distance between polyhedra, bounding variance, Markowitz optimization, and second order cone programming is used for Quadratic Optimization.

  14. Using sparsity information for iterative phase retrieval in x-ray propagation imaging.

    PubMed

    Pein, A; Loock, S; Plonka, G; Salditt, T

    2016-04-18

    For iterative phase retrieval algorithms in near field x-ray propagation imaging experiments with a single distance measurement, it is indispensable to have a strong constraint based on a priori information about the specimen; for example, information about the specimen's support. Recently, Loock and Plonka proposed to use the a priori information that the exit wave is sparsely represented in a certain directional representation system, a so-called shearlet system. In this work, we extend this approach to complex-valued signals by applying the new shearlet constraint to amplitude and phase separately. Further, we demonstrate its applicability to experimental data.

  15. Near-Field Diffraction Imaging from Multiple Detection Planes

    NASA Astrophysics Data System (ADS)

    Loetgering, L.; Golembusch, M.; Hammoud, R.; Wilhein, T.

    2017-06-01

    We present diffraction imaging results obtained from multiple near-field diffraction constraints. An iterative phase retrieval algorithm was implemented that uses data redundancy achieved by measuring near-field diffraction intensities at various sample-detector distances. The procedure allows for reconstructing the exit surface wave of a sample within a multiple constraint satisfaction framework neither making use of a priori knowledge as enforced in coherent diffraction imaging (CDI) nor exact scanning grid knowledge as required in ptychography. We also investigate the potential of the presented technique to deal with polychromatic radiation as important for potential application in diffraction imaging by means of tabletop EUV and X-ray sources.

  16. Collecting and Applying Usability Data from Distance Learners

    ERIC Educational Resources Information Center

    Mitchell, Emily; West, Brandon

    2017-01-01

    Growth of their college's off-campus and online course offerings led librarians at SUNY Oswego to run usability tests with off-campus students to compensate for a lack of responses from this population during earlier usability testing. Constraints on testing with off-campus students included lack of funding and librarian time, as well as…

  17. Role Assignment and Sense of Community in an Online Course

    ERIC Educational Resources Information Center

    Jiang, Wenting

    2016-01-01

    More and more educational institutions have been moving towards delivering courses and programs at a distance. Although asynchronous online courses overcome the constraints of time, students feel isolated due to the lack of real-time communications. One possible solution to overcome this isolation been suggested that learner's online behavior and…

  18. Optimizing stellarator coil winding surfaces with Regcoil

    NASA Astrophysics Data System (ADS)

    Bader, Aaron; Landreman, Matt; Anderson, David; Hegna, Chris

    2017-10-01

    We show initial attempts at optimizing a coil winding surface using the Regcoil code [1] for selected quasi helically symmetric equilibria. We implement a generic optimization scheme which allows for variation of the winding surface to allow for improved diagnostic access and allow for flexible divertor solutions. Regcoil and similar coil-solving algorithms require a user-input winding surface, on which the coils lie. Simple winding surfaces created by uniformly expanding the plasma boundary may not be ideal. Engineering constraints on reactor design require a coil-plasma separation sufficient for the introduction of neutron shielding and a tritium generating blanket. This distance can be the limiting factor in determining reactor size. Furthermore, expanding coils in other regions, where possible, can be useful for diagnostic and maintenance access along with providing sufficient room for a divertor. We minimize a target function that includes as constraints, the minimum coil-plasma distance, the winding surface volume, and the normal magnetic field on the plasma boundary. Results are presented for two quasi-symmetric equilibria at different aspect ratios. Work supported by the US DOE under Grant DE-FG02-93ER54222.

  19. Error control techniques for satellite and space communications

    NASA Technical Reports Server (NTRS)

    Costello, Daniel J., Jr.

    1992-01-01

    Worked performed during the reporting period is summarized. Construction of robustly good trellis codes for use with sequential decoding was developed. The robustly good trellis codes provide a much better trade off between free distance and distance profile. The unequal error protection capabilities of convolutional codes was studied. The problem of finding good large constraint length, low rate convolutional codes for deep space applications is investigated. A formula for computing the free distance of 1/n convolutional codes was discovered. Double memory (DM) codes, codes with two memory units per unit bit position, were studied; a search for optimal DM codes is being conducted. An algorithm for constructing convolutional codes from a given quasi-cyclic code was developed. Papers based on the above work are included in the appendix.

  20. Limits on the Higgs boson lifetime and width from its decay to four charged leptons

    DOE PAGES

    Khachatryan, Vardan

    2015-10-22

    Constraints on the lifetime and width of the Higgs boson are obtained from H → ZZ → 4ℓ events using data recorded by the CMS experiment during the LHC run 1 with an integrated luminosity of 5.1 and 19.7 fb -1 at a center-of-mass energy of 7 and 8 TeV, respectively. The measurement of the Higgs boson lifetime is derived from its flight distance in the CMS detector with an upper bound of τ H < 1.9 × 10 -13 s at the 95% confidence level (C.L.), corresponding to a lower bound on the width of Γ H > 3.5more » × 10 -9 MeV. The measurement of the width is obtained from an off-shell production technique, generalized to include anomalous couplings of the Higgs boson to two electroweak bosons. From our measurement, a joint constraint is set on the Higgs boson width and a parameter f ΛQ that expresses an anomalous coupling contribution as an on-shell cross-section fraction. Additionally, the limit on the Higgs boson width is Γ H<46 MeV with f ΛQ unconstrained and Γ H < 26 MeV for f ΛQ = 0 at the 95% C.L. The constraint f ΛQ < 3.8 × 10 -3 at the 95% C.L. is obtained for the expected standard model Higgs boson width.« less

  1. When clusters collide: constraints on antimatter on the largest scales

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Steigman, Gary, E-mail: steigman@mps.ohio-state.edu

    2008-10-15

    Observations have ruled out the presence of significant amounts of antimatter in the Universe on scales ranging from the solar system, to the Galaxy, to groups and clusters of galaxies, and even to distances comparable to the scale of the present horizon. Except for the model-dependent constraints on the largest scales, the most significant upper limits to diffuse antimatter in the Universe are those on the {approx}Mpc scale of clusters of galaxies provided by the EGRET upper bounds to annihilation gamma rays from galaxy clusters whose intracluster gas is revealed through its x-ray emission. On the scale of individual clustersmore » of galaxies the upper bounds to the fraction of mixed matter and antimatter for the 55 clusters from a flux-limited x-ray survey range from 5 Multiplication-Sign 10{sup -9} to <1 Multiplication-Sign 10{sup -6}, strongly suggesting that individual clusters of galaxies are made entirely of matter or of antimatter. X-ray and gamma-ray observations of colliding clusters of galaxies, such as the Bullet Cluster, permit these constraints to be extended to even larger scales. If the observations of the Bullet Cluster, where the upper bound to the antimatter fraction is found to be <3 Multiplication-Sign 10{sup -6}, can be generalized to other colliding clusters of galaxies, cosmologically significant amounts of antimatter will be excluded on scales of order {approx}20 Mpc (M{approx}5 Multiplication-Sign 10{sup 15}M{sub sun})« less

  2. Mechanistic analysis of multi-omics datasets to generate kinetic parameters for constraint-based metabolic models.

    PubMed

    Cotten, Cameron; Reed, Jennifer L

    2013-01-30

    Constraint-based modeling uses mass balances, flux capacity, and reaction directionality constraints to predict fluxes through metabolism. Although transcriptional regulation and thermodynamic constraints have been integrated into constraint-based modeling, kinetic rate laws have not been extensively used. In this study, an in vivo kinetic parameter estimation problem was formulated and solved using multi-omic data sets for Escherichia coli. To narrow the confidence intervals for kinetic parameters, a series of kinetic model simplifications were made, resulting in fewer kinetic parameters than the full kinetic model. These new parameter values are able to account for flux and concentration data from 20 different experimental conditions used in our training dataset. Concentration estimates from the simplified kinetic model were within one standard deviation for 92.7% of the 790 experimental measurements in the training set. Gibbs free energy changes of reaction were calculated to identify reactions that were often operating close to or far from equilibrium. In addition, enzymes whose activities were positively or negatively influenced by metabolite concentrations were also identified. The kinetic model was then used to calculate the maximum and minimum possible flux values for individual reactions from independent metabolite and enzyme concentration data that were not used to estimate parameter values. Incorporating these kinetically-derived flux limits into the constraint-based metabolic model improved predictions for uptake and secretion rates and intracellular fluxes in constraint-based models of central metabolism. This study has produced a method for in vivo kinetic parameter estimation and identified strategies and outcomes of kinetic model simplification. We also have illustrated how kinetic constraints can be used to improve constraint-based model predictions for intracellular fluxes and biomass yield and identify potential metabolic limitations through the integrated analysis of multi-omics datasets.

  3. Mechanistic analysis of multi-omics datasets to generate kinetic parameters for constraint-based metabolic models

    PubMed Central

    2013-01-01

    Background Constraint-based modeling uses mass balances, flux capacity, and reaction directionality constraints to predict fluxes through metabolism. Although transcriptional regulation and thermodynamic constraints have been integrated into constraint-based modeling, kinetic rate laws have not been extensively used. Results In this study, an in vivo kinetic parameter estimation problem was formulated and solved using multi-omic data sets for Escherichia coli. To narrow the confidence intervals for kinetic parameters, a series of kinetic model simplifications were made, resulting in fewer kinetic parameters than the full kinetic model. These new parameter values are able to account for flux and concentration data from 20 different experimental conditions used in our training dataset. Concentration estimates from the simplified kinetic model were within one standard deviation for 92.7% of the 790 experimental measurements in the training set. Gibbs free energy changes of reaction were calculated to identify reactions that were often operating close to or far from equilibrium. In addition, enzymes whose activities were positively or negatively influenced by metabolite concentrations were also identified. The kinetic model was then used to calculate the maximum and minimum possible flux values for individual reactions from independent metabolite and enzyme concentration data that were not used to estimate parameter values. Incorporating these kinetically-derived flux limits into the constraint-based metabolic model improved predictions for uptake and secretion rates and intracellular fluxes in constraint-based models of central metabolism. Conclusions This study has produced a method for in vivo kinetic parameter estimation and identified strategies and outcomes of kinetic model simplification. We also have illustrated how kinetic constraints can be used to improve constraint-based model predictions for intracellular fluxes and biomass yield and identify potential metabolic limitations through the integrated analysis of multi-omics datasets. PMID:23360254

  4. Sequence specificity, statistical potentials, and three-dimensional structure prediction with self-correcting distance geometry calculations of beta-sheet formation in proteins.

    PubMed Central

    Zhu, H.; Braun, W.

    1999-01-01

    A statistical analysis of a representative data set of 169 known protein structures was used to analyze the specificity of residue interactions between spatial neighboring strands in beta-sheets. Pairwise potentials were derived from the frequency of residue pairs in nearest contact, second nearest and third nearest contacts across neighboring beta-strands compared to the expected frequency of residue pairs in a random model. A pseudo-energy function based on these statistical pairwise potentials recognized native beta-sheets among possible alternative pairings. The native pairing was found within the three lowest energies in 73% of the cases in the training data set and in 63% of beta-sheets in a test data set of 67 proteins, which were not part of the training set. The energy function was also used to detect tripeptides, which occur frequently in beta-sheets of native proteins. The majority of native partners of tripeptides were distributed in a low energy range. Self-correcting distance geometry (SECODG) calculations using distance constraints sets derived from possible low energy pairing of beta-strands uniquely identified the native pairing of the beta-sheet in pancreatic trypsin inhibitor (BPTI). These results will be useful for predicting the structure of proteins from their amino acid sequence as well as for the design of proteins containing beta-sheets. PMID:10048326

  5. Phi Index: A New Metric to Test the Flush Early and Avoid the Rush Hypothesis

    PubMed Central

    Samia, Diogo S. M.; Blumstein, Daniel T.

    2014-01-01

    Optimal escape theory states that animals should counterbalance the costs and benefits of flight when escaping from a potential predator. However, in apparent contradiction with this well-established optimality model, birds and mammals generally initiate escape soon after beginning to monitor an approaching threat, a phenomena codified as the “Flush Early and Avoid the Rush” (FEAR) hypothesis. Typically, the FEAR hypothesis is tested using correlational statistics and is supported when there is a strong relationship between the distance at which an individual first responds behaviorally to an approaching predator (alert distance, AD), and its flight initiation distance (the distance at which it flees the approaching predator, FID). However, such correlational statistics are both inadequate to analyze relationships constrained by an envelope (such as that in the AD-FID relationship) and are sensitive to outliers with high leverage, which can lead one to erroneous conclusions. To overcome these statistical concerns we develop the phi index (Φ), a distribution-free metric to evaluate the goodness of fit of a 1∶1 relationship in a constraint envelope (the prediction of the FEAR hypothesis). Using both simulation and empirical data, we conclude that Φ is superior to traditional correlational analyses because it explicitly tests the FEAR prediction, is robust to outliers, and it controls for the disproportionate influence of observations from large predictor values (caused by the constrained envelope in AD-FID relationship). Importantly, by analyzing the empirical data we corroborate the strong effect that alertness has on flight as stated by the FEAR hypothesis. PMID:25405872

  6. Phi index: a new metric to test the flush early and avoid the rush hypothesis.

    PubMed

    Samia, Diogo S M; Blumstein, Daniel T

    2014-01-01

    Optimal escape theory states that animals should counterbalance the costs and benefits of flight when escaping from a potential predator. However, in apparent contradiction with this well-established optimality model, birds and mammals generally initiate escape soon after beginning to monitor an approaching threat, a phenomena codified as the "Flush Early and Avoid the Rush" (FEAR) hypothesis. Typically, the FEAR hypothesis is tested using correlational statistics and is supported when there is a strong relationship between the distance at which an individual first responds behaviorally to an approaching predator (alert distance, AD), and its flight initiation distance (the distance at which it flees the approaching predator, FID). However, such correlational statistics are both inadequate to analyze relationships constrained by an envelope (such as that in the AD-FID relationship) and are sensitive to outliers with high leverage, which can lead one to erroneous conclusions. To overcome these statistical concerns we develop the phi index (Φ), a distribution-free metric to evaluate the goodness of fit of a 1:1 relationship in a constraint envelope (the prediction of the FEAR hypothesis). Using both simulation and empirical data, we conclude that Φ is superior to traditional correlational analyses because it explicitly tests the FEAR prediction, is robust to outliers, and it controls for the disproportionate influence of observations from large predictor values (caused by the constrained envelope in AD-FID relationship). Importantly, by analyzing the empirical data we corroborate the strong effect that alertness has on flight as stated by the FEAR hypothesis.

  7. The Impact of Geometrical Constraints on Collisionless Magnetic Reconnection

    NASA Technical Reports Server (NTRS)

    Hesse, Michael; Aunai, Nico; Kuznetsova, Masha; Frolov, Rebekah; Black, Carrrie

    2012-01-01

    One of the most often cited features associated with collisionless magnetic reconnection is a Hall-type magnetic field, which leads, in antiparallel geometries, to a quadrupolar magnetic field signature. The combination of this out of plane magnetic field with the reconnection in-plane magnetic field leads to angling of magnetic flux tubes out of the plane defined by the incoming magnetic flux. Because it is propagated by Whistler waves, the quadrupolar field can extend over large distances in relatively short amounts of time - in fact, it will extend to the boundary of any modeling domain. In reality, however, the surrounding plasma and magnetic field geometry, defined, for example, by the overall solar wind flow, will in practice limit the extend over which a flux tube can be angled out of the main plain. This poses the question to what extent geometric constraints limit or control the reconnection process and this is the question investigated in this presentation. The investigation will involve a comparison of calculations, where open boundary conditions are set up to mimic either free or constrained geometries. We will compare momentum transport, the geometry of the reconnection regions, and the acceleration if ions and electrons to provide the current sheet in the outflow jet.

  8. Statistical thermodynamics of amphiphile chains in micelles

    PubMed Central

    Ben-Shaul, A.; Szleifer, I.; Gelbart, W. M.

    1984-01-01

    The probability distribution of amphiphile chain conformations in micelles of different geometries is derived through maximization of their packing entropy. A lattice model, first suggested by Dill and Flory, is used to represent the possible chain conformations in the micellar core. The polar heads of the chains are assumed to be anchored to the micellar surface, with the other chain segments occupying all lattice sites in the interior of the micelle. This “volume-filling” requirement, the connectivity of the chains, and the geometry of the micelle define constraints on the possible probability distributions of chain conformations. The actual distribution is derived by maximizing the chain's entropy subject to these constraints; “reversals” of the chains back towards the micellar surface are explicitly included. Results are presented for amphiphiles organized in planar bilayers and in cylindrical and spherical micelles of different sizes. It is found that, for all three geometries, the bond order parameters decrease as a function of the bond distance from the polar head, in accordance with recent experimental data. The entropy differences associated with geometrical changes are shown to be significant, suggesting thereby the need to include curvature (environmental)-dependent “tail” contributions in statistical thermodynamic treatments of micellization. PMID:16593492

  9. THE FIRST BENT DOUBLE LOBE RADIO SOURCE IN A KNOWN CLUSTER FILAMENT: CONSTRAINTS ON THE INTRAFILAMENT MEDIUM

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Edwards, Louise O. V.; Fadda, Dario; Frayer, David T., E-mail: louise@ipac.caltech.ed

    2010-12-01

    We announce the first discovery of a bent double lobe radio source (DLRS) in a known cluster filament. The bent DLRS is found at a distance of 3.4 Mpc from the center of the rich galaxy cluster, A1763. We derive a bend angle {alpha} = 25{sup 0}, and infer that the source is most likely seen at a viewing angle of {Phi} = 10{sup 0}. From measuring the flux in the jet between the core and further lobe and assuming a spectral index of 1, we calculate the minimum pressure in the jet, (8.0 {+-} 3.2) x 10{sup -13} dynmore » cm{sup -2}, and derive constraints on the intrafilament medium (IFM) assuming the bend of the jet is due to ram pressure. We constrain the IFM to be between (1-20) x 10{sup -29} gm cm{sup -3}. This is consistent with recent direct probes of the IFM and theoretical models. These observations justify future searches for bent double lobe radio sources located several megaparsecs from cluster cores, as they may be good markers of super cluster filaments.« less

  10. Optimal Routing and Control of Multiple Agents Moving in a Transportation Network and Subject to an Arrival Schedule and Separation Constraints

    NASA Technical Reports Server (NTRS)

    Sadovsky, A. V.; Davis, D.; Isaacson, D. R.

    2012-01-01

    We address the problem of navigating a set of moving agents, e.g. automated guided vehicles, through a transportation network so as to bring each agent to its destination at a specified time. Each pair of agents is required to be separated by a minimal distance, generally agent-dependent, at all times. The speed range, initial position, required destination, and required time of arrival at destination for each agent are assumed provided. The movement of each agent is governed by a controlled differential equation (state equation). The problem consists in choosing for each agent a path and a control strategy so as to meet the constraints and reach the destination at the required time. This problem arises in various fields of transportation, including Air Traffic Management and train coordination, and in robotics. The main contribution of the paper is a model that allows to recast this problem as a decoupled collection of problems in classical optimal control and is easily generalized to the case when inertia cannot be neglected. Some qualitative insight into solution behavior is obtained using the Pontryagin Maximum Principle. Sample numerical solutions are computed using a numerical optimal control solver.

  11. Advantages of soft versus hard constraints in self-modeling curve resolution problems. Alternating least squares with penalty functions.

    PubMed

    Gemperline, Paul J; Cash, Eric

    2003-08-15

    A new algorithm for self-modeling curve resolution (SMCR) that yields improved results by incorporating soft constraints is described. The method uses least squares penalty functions to implement constraints in an alternating least squares algorithm, including nonnegativity, unimodality, equality, and closure constraints. By using least squares penalty functions, soft constraints are formulated rather than hard constraints. Significant benefits are (obtained using soft constraints, especially in the form of fewer distortions due to noise in resolved profiles. Soft equality constraints can also be used to introduce incomplete or partial reference information into SMCR solutions. Four different examples demonstrating application of the new method are presented, including resolution of overlapped HPLC-DAD peaks, flow injection analysis data, and batch reaction data measured by UV/visible and near-infrared spectroscopy (NIR). Each example was selected to show one aspect of the significant advantages of soft constraints over traditionally used hard constraints. Incomplete or partial reference information into self-modeling curve resolution models is described. The method offers a substantial improvement in the ability to resolve time-dependent concentration profiles from mixture spectra recorded as a function of time.

  12. Observation of core sensitive phases: Constraints on the velocity and attenuation profile in the vicinity of the inner-core boundary

    NASA Astrophysics Data System (ADS)

    Adam, J. M.-C.; Ibourichène, A.; Romanowicz, B.

    2018-02-01

    We measured more than three thousand differential travel-times and amplitude ratios of PKPBC , PKPBC-diff , PKPAB and PKPDF phases in the epicentral distance range [149°-171°], from high quality records of globally distributed broadband stations. In particular, this is the largest collection of differential measurements of PKPBC-diff compared to PKPDF , extending by ∼ 10 ° the epicentral distance range in which the diffracted PKPBC phase has been observed globally. We used forward modelling of waveforms using the Direct Solution Method combined with a grid-search approach to explore attenuation and P-velocity structure in the vicinity of the inner core boundary (ICB) that can explain our observations. We find that, in order to simultaneously explain differential travel times and amplitude ratios of PKPBC , PKPBC-diff with respect to PKPDF out to distances of 165 ° , while fitting PKPAB /PKPDF within measurement errors, it is necessary to introduce a ∼ 450km zone of reduced bulk quality factor (Qκ ∼ 600) at the base of the outer core, while Qκ is close to 200 in a layer ∼ 150km thick at the top of the inner core. Concurrently, the P-velocity in the last 100 km of the outer-core is on average about 0.5 % slower than in the reference model AK 135 , while it is about 0.5 % faster in the top 150 km of the inner-core, resulting in a P-velocity jump at the inner core boundary slightly higher than in model AK 135 . However, this model underpredicts PKPBC-diff /PKPDF amplitude ratios at distances larger than 165 ° . Reducing Qκ even further in the last 100 km of the outer-core (down to Qκ = 50) provides a good fit to these data but it is not compatible with measurements of PKiKP/PKPDF amplitude ratios in the distance range 120-140°. We also considered a previously assembled global collection of "M phase" data. The M phase is a large energy in the coda of the PKPBC and PKPBC-diff that is not predicted by current 1 D reference seismic models, but most likely originates at the base of the outer-core. Our preferred model predicts the presence of an M phase, but significantly underestimates its amplitude. In order to explain the large amplitude of the M-phase and that of PKPBC-diff at distances larger than 165 ° without significantly affecting PKiKP amplitudes, it seems necessary to invoke a process that would produce strong scattering for diffracted phases in the immediate vicinity of the ICB, on the outer core side. Clusters of solid particles suspended in the fluid core or topography of the ICB are possible candidates that should be explored further.

  13. Support vector methods for survival analysis: a comparison between ranking and regression approaches.

    PubMed

    Van Belle, Vanya; Pelckmans, Kristiaan; Van Huffel, Sabine; Suykens, Johan A K

    2011-10-01

    To compare and evaluate ranking, regression and combined machine learning approaches for the analysis of survival data. The literature describes two approaches based on support vector machines to deal with censored observations. In the first approach the key idea is to rephrase the task as a ranking problem via the concordance index, a problem which can be solved efficiently in a context of structural risk minimization and convex optimization techniques. In a second approach, one uses a regression approach, dealing with censoring by means of inequality constraints. The goal of this paper is then twofold: (i) introducing a new model combining the ranking and regression strategy, which retains the link with existing survival models such as the proportional hazards model via transformation models; and (ii) comparison of the three techniques on 6 clinical and 3 high-dimensional datasets and discussing the relevance of these techniques over classical approaches fur survival data. We compare svm-based survival models based on ranking constraints, based on regression constraints and models based on both ranking and regression constraints. The performance of the models is compared by means of three different measures: (i) the concordance index, measuring the model's discriminating ability; (ii) the logrank test statistic, indicating whether patients with a prognostic index lower than the median prognostic index have a significant different survival than patients with a prognostic index higher than the median; and (iii) the hazard ratio after normalization to restrict the prognostic index between 0 and 1. Our results indicate a significantly better performance for models including regression constraints above models only based on ranking constraints. This work gives empirical evidence that svm-based models using regression constraints perform significantly better than svm-based models based on ranking constraints. Our experiments show a comparable performance for methods including only regression or both regression and ranking constraints on clinical data. On high dimensional data, the former model performs better. However, this approach does not have a theoretical link with standard statistical models for survival data. This link can be made by means of transformation models when ranking constraints are included. Copyright © 2011 Elsevier B.V. All rights reserved.

  14. The diffusion of the distance Entomology Master's Degree Program at the University of Nebraska Lincoln: A descriptive case study

    NASA Astrophysics Data System (ADS)

    Hubbell, Jody M.

    This study explored three selected phases of Rogers' (1995) Diffusion of Innovations Theory to examine the diffusion process of the distance Entomology Master's Degree program at the University of Nebraska, Lincoln. A qualitative descriptive case study approach incorporated semi-structured interviews with individuals involved in one or more of the three stages: Development, Implementation, and Institutionalization. Documents and archival evidence were used to triangulate findings. This research analyzed descriptions of the program as it moved from the Development, to the Implementation, and finally, the Institutionalization stages of diffusion. Each respective stage was examined through open and axial coding. Process coding identified themes common to two or more diffusion stages, and explored the evolution of themes from one diffusion stage to the next. At a time of significant budget constraints, many departments were faced with the possibility of merger or dissolution. The Entomology Master's Degree Program evolved from being an entrepreneurial means to prevent departmental dissolution to eventually being viewed as a model for the development of similar programs across this university and other institutions of higher education. During this evolution, the program was reinvented to meet the broader needs of industry and a global student market. One finding not consistent with Rogers' model was that smaller, rather than larger, departmental size contributed to the success of the program. Within this small department, faculty members were able to share their experiences and knowledge with each other on a regular basis, which promoted greater acceptance of the distance program. How quality and rigor may be defined and measured was a key issue in each respective stage. In this specific case, quality and rigor was initially a comparison of on-campus and distance course content and then moved to program-based assessment and measures of student outcomes such as job placement rates.

  15. Examining Dense Data Usage near the Regions with Severe Storms in All-Sky Microwave Radiance Data Assimilation and Impacts on GEOS Hurricane Analyses

    NASA Technical Reports Server (NTRS)

    Kim, Min-Jeong; Jin, Jianjun; McCarty, Will; El Akkraoui, Amal; Todling, Ricardo; Gelaro, Ron

    2018-01-01

    Many numerical weather prediction (NWP) centers assimilate radiances affected by clouds and precipitation from microwave sensors, with the expectation that these data can provide critical constraints on meteorological parameters in dynamically sensitive regions to make significant impacts on forecast accuracy for precipitation. The Global Modeling and Assimilation Office (GMAO) at NASA Goddard Space Flight Center assimilates all-sky microwave radiance data from various microwave sensors such as all-sky GPM Microwave Imager (GMI) radiance in the Goddard Earth Observing System (GEOS) atmospheric data assimilation system (ADAS), which includes the GEOS atmospheric model, the Gridpoint Statistical Interpolation (GSI) atmospheric analysis system, and the Goddard Aerosol Assimilation System (GAAS). So far, most of NWP centers apply same large data thinning distances, that are used in clear-sky radiance data to avoid correlated observation errors, to all-sky microwave radiance data. For example, NASA GMAO is applying 145 km thinning distances for most of satellite radiance data including microwave radiance data in which all-sky approach is implemented. Even with these coarse observation data usage in all-sky assimilation approach, noticeable positive impacts from all-sky microwave data on hurricane track forecasts were identified in GEOS-5 system. The motivation of this study is based on the dynamic thinning distance method developed in our all-sky framework to use of denser data in cloudy and precipitating regions due to relatively small spatial correlations of observation errors. To investigate the benefits of all-sky microwave radiance on hurricane forecasts, several hurricane cases selected between 2016-2017 are examined. The dynamic thinning distance method is utilized in our all-sky approach to understand the sources and mechanisms to explain the benefits of all-sky microwave radiance data from various microwave radiance sensors like Advanced Microwave Sounder Unit (AMSU-A), Microwave Humidity Sounder (MHS), and GMI on GEOS-5 analyses and forecasts of various hurricanes.

  16. The clustering of galaxies in the completed SDSS-III Baryon Oscillation Spectroscopic Survey: theoretical systematics and Baryon Acoustic Oscillations in the galaxy correlation function

    NASA Astrophysics Data System (ADS)

    Vargas-Magaña, Mariana; Ho, Shirley; Cuesta, Antonio J.; O'Connell, Ross; Ross, Ashley J.; Eisenstein, Daniel J.; Percival, Will J.; Grieb, Jan Niklas; Sánchez, Ariel G.; Tinker, Jeremy L.; Tojeiro, Rita; Beutler, Florian; Chuang, Chia-Hsun; Kitaura, Francisco-Shu; Prada, Francisco; Rodríguez-Torres, Sergio A.; Rossi, Graziano; Seo, Hee-Jong; Brownstein, Joel R.; Olmstead, Matthew; Thomas, Daniel

    2018-06-01

    We investigate the potential sources of theoretical systematics in the anisotropic Baryon Acoustic Oscillation (BAO) distance scale measurements from the clustering of galaxies in configuration space using the final Data Release (DR12) of the Baryon Oscillation Spectroscopic Survey (BOSS). We perform a detailed study of the impact on BAO measurements from choices in the methodology such as fiducial cosmology, clustering estimators, random catalogues, fitting templates, and covariance matrices. The theoretical systematic uncertainties in BAO parameters are found to be 0.002 in the isotropic dilation α and 0.003 in the quadrupolar dilation ɛ. The leading source of systematic uncertainty is related to the reconstruction techniques. Theoretical uncertainties are sub-dominant compared with the statistical uncertainties for BOSS survey, accounting 0.2σstat for α and 0.25σstat for ɛ (σα, stat ˜ 0.010 and σɛ, stat ˜ 0.012, respectively). We also present BAO-only distance scale constraints from the anisotropic analysis of the correlation function. Our constraints on the angular diameter distance DA(z) and the Hubble parameter H(z), including both statistical and theoretical systematic uncertainties, are 1.5 per cent and 2.8 per cent at zeff = 0.38, 1.4 per cent and 2.4 per cent at zeff = 0.51, and 1.7 per cent and 2.6 per cent at zeff = 0.61. This paper is part of a set that analyses the final galaxy clustering data set from BOSS. The measurements and likelihoods presented here are cross-checked with other BAO analysis in Alam et al. The systematic error budget concerning the methodology on post-reconstruction BAO analysis presented here is used in Alam et al. to produce the final cosmological constraints from BOSS.

  17. Recharge and Topographical Controls on Groundwater Circulation in Shallow Crystalline Rock Aquifers revealed by CFC-based Age Data

    NASA Astrophysics Data System (ADS)

    Kolbe, T.; Abbott, B. W.; Marçais, J.; Thomas, Z.; Aquilina, L.; Labasque, T.; Pinay, G.; De Dreuzy, J. R.

    2016-12-01

    Groundwater transit time and flow path are key factors controlling nitrogen retention and removal capacity at the catchment scale (Abbott et al., 2016), but the relative importance of hydrogeological and topographical factors in determining these parameters remains uncertain (Kolbe et al., 2016). To address this unknown, we used numerical modelling techniques calibrated with CFC groundwater age data to quantify transit time and flow path in an unconfined aquifer in Brittany, France. We assessed the relative importance of parameters (aquifer depth, porosity, arrangement of geological layers, and permeability profile), hydrology (recharge rate), and topography in determining characteristic flow distances (Leray et al., 2016). We found that groundwater flow was highly local (mean travel distance of 350 m) but also relatively old (mean CFC age of 40 years). Sensitivity analysis revealed that groundwater travel distances were not sensitive to geological parameters within the constraints of the CFC age data. However, circulation was sensitive to topography in lowland areas where the groundwater table was close to the land surface, and to recharge rate in upland areas where water input modulated the free surface of the aquifer. We quantified these differences with a local groundwater ratio (rGW-LOCAL) defined as the mean groundwater travel distance divided by the equivalent surface distance water would have traveled along the land surface. Lowland rGW-LOCAL was near 1, indicating primarily topographic controls. Upland rGW-LOCALwas 1.6, meaning the groundwater recharge area was substantially larger than the topographically-defined catchment. This ratio was applied to other catchments in Brittany to test its relevance in comparing controls on groundwater circulation within and among catchments. REFERENCES Abbott et al., 2016, Using multi-tracer inference to move beyond single-catchment ecohydrology. Earth-Science Reviews. Kolbe et al., 2016, Coupling 3D groundwater modeling with CFC-based age dating to classify local groundwater circulation in an unconfined crystalline aquifer. J. Hydrol. Leray et al., 2016, Residence time distributions for hydrologic systems: Mechanistic foundations and steady-state analytical solutions. J. Hydrol.

  18. A constraint optimization based virtual network mapping method

    NASA Astrophysics Data System (ADS)

    Li, Xiaoling; Guo, Changguo; Wang, Huaimin; Li, Zhendong; Yang, Zhiwen

    2013-03-01

    Virtual network mapping problem, maps different virtual networks onto the substrate network is an extremely challenging work. This paper proposes a constraint optimization based mapping method for solving virtual network mapping problem. This method divides the problem into two phases, node mapping phase and link mapping phase, which are all NP-hard problems. Node mapping algorithm and link mapping algorithm are proposed for solving node mapping phase and link mapping phase, respectively. Node mapping algorithm adopts the thinking of greedy algorithm, mainly considers two factors, available resources which are supplied by the nodes and distance between the nodes. Link mapping algorithm is based on the result of node mapping phase, adopts the thinking of distributed constraint optimization method, which can guarantee to obtain the optimal mapping with the minimum network cost. Finally, simulation experiments are used to validate the method, and results show that the method performs very well.

  19. Assessing Potential Energy Savings in Household Travel: Methodological and Empirical Considerations of Vehicle Capability Constraints and Multi-day Activity Patterns

    NASA Astrophysics Data System (ADS)

    Bolon, Kevin M.

    The lack of multi-day data for household travel and vehicle capability requirements is an impediment to evaluations of energy savings strategies, since (1) travel requirements vary from day-to-day, and (2) energy-saving transportation options often have reduced capability. This work demonstrates a survey methodology and modeling system for evaluating the energy-savings potential of household travel, considering multi-day travel requirements and capability constraints imposed by the available transportation resources. A stochastic scheduling model is introduced---the multi-day Household Activity Schedule Estimator (mPHASE)---which generates synthetic daily schedules based on "fuzzy" descriptions of activity characteristics using a finite-element representation of activity flexibility, coordination among household members, and scheduling conflict resolution. Results of a thirty-household pilot study are presented in which responses to an interactive computer assisted personal interview were used as inputs to the mPHASE model in order to illustrate the feasibility of generating complex, realistic multi-day household schedules. Study vehicles were equipped with digital cameras and GPS data acquisition equipment to validate the model results. The synthetically generated schedules captured an average of 60 percent of household travel distance, and exhibited many of the characteristics of complex household travel, including day-to-day travel variation, and schedule coordination among household members. Future advances in the methodology may improve the model results, such as encouraging more detailed and accurate responses by providing a selection of generated schedules during the interview. Finally, the Constraints-based Transportation Resource Assignment Model (CTRAM) is introduced. Using an enumerative optimization approach, CTRAM determines the energy-minimizing vehicle-to-trip assignment decisions, considering trip schedules, occupancy, and vehicle capability. Designed to accept either actual or synthetic schedules, results of an application of the optimization model to the 2001 and 2009 National Household Travel Survey data show that U.S. households can reduce energy use by 10 percent, on average, by modifying the assignment of existing vehicles to trips. Households in 2009 show a higher tendency to assign vehicles optimally than in 2001, and multi-vehicle households with diverse fleets have greater savings potential, indicating that fleet modification strategies may be effective, particularly under higher energy price conditions.

  20. Modeling of Ground Deformation and Shallow Surface Waves Generated by Martian Dust Devils and Perspectives for Near-Surface Structure Inversion

    NASA Astrophysics Data System (ADS)

    Kenda, Balthasar; Lognonné, Philippe; Spiga, Aymeric; Kawamura, Taichi; Kedar, Sharon; Banerdt, William Bruce; Lorenz, Ralph; Banfield, Don; Golombek, Matthew

    2017-10-01

    We investigated the possible seismic signatures of dust devils on Mars, both at long and short period, based on the analysis of Earth data and on forward modeling for Mars. Seismic and meteorological data collected in the Mojave Desert, California, recorded the signals generated by dust devils. In the 10-100 s band, the quasi-static surface deformation triggered by pressure fluctuations resulted in detectable ground-tilt effects: these are in good agreement with our modeling based on Sorrells' theory. In addition, high-frequency records also exhibit a significant excitation in correspondence to dust devil episodes. Besides wind noise, this signal includes shallow surface waves due to the atmosphere-surface coupling and is used for a preliminary inversion of the near-surface S-wave profile down to 50 m depth. In the case of Mars, we modeled the long-period signals generated by the pressure field resulting from turbulence-resolving Large-Eddy Simulations. For typical dust-devil-like vortices with pressure drops of a couple Pascals, the corresponding horizontal acceleration is of a few nm/s2 for rocky subsurface models and reaches 10-20 nm/s2 for weak regolith models. In both cases, this signal can be detected by the Very-Broad Band seismometers of the InSight/SEIS experiment up to a distance of a few hundred meters from the vortex, the amplitude of the signal decreasing as the inverse of the distance. Atmospheric vortices are thus expected to be detected at the InSight landing site; the analysis of their seismic and atmospheric signals could lead to additional constraints on the near-surface structure, more precisely on the ground compliance and possibly on the seismic velocities.

  1. Coarse-Grained Model for Water Involving a Virtual Site.

    PubMed

    Deng, Mingsen; Shen, Hujun

    2016-02-04

    In this work, we propose a new coarse-grained (CG) model for water by combining the features of two popular CG water models (BMW and MARTINI models) as well as by adopting a topology similar to that of the TIP4P water model. In this CG model, a CG unit, representing four real water molecules, consists of a virtual site, two positively charged particles, and a van der Waals (vdW) interaction center. Distance constraint is applied to the bonds formed between the vdW interaction center and the positively charged particles. The virtual site, which carries a negative charge, is determined by the locations of the two positively charged particles and the vdW interaction center. For the new CG model of water, we coined the name "CAVS" (charge is attached to a virtual site) due to the involvment of the virtual site. After being tested in molecular dynamic (MD) simulations of bulk water at various time steps, under different temperatures and in different salt (NaCl) concentrations, the CAVS model offers encouraging predictions for some bulk properties of water (such as density, dielectric constant, etc.) when compared to experimental ones.

  2. Central-place foraging and ecological effects of an invasive predator across multiple habitats.

    PubMed

    Benkwitt, Cassandra E

    2016-10-01

    Cross-habitat foraging movements of predators can have widespread implications for predator and prey populations, community structure, nutrient transfer, and ecosystem function. Although central-place foraging models and other aspects of optimal foraging theory focus on individual predator behavior, they also provide useful frameworks for understanding the effects of predators on prey populations across multiple habitats. However, few studies have examined both the foraging behavior and ecological effects of nonnative predators across multiple habitats, and none has tested whether nonnative predators deplete prey in a manner predicted by these foraging models. I conducted behavioral observations of invasive lionfish (Pterois volitans) to determine whether they exhibit foraging movements similar to other central-place consumers. Then, I used a manipulative field experiment to test whether their effects on prey populations are consistent with three qualitative predictions from optimal foraging models. Specifically, I predicted that the effects of invasive lionfish on native prey will (1) occur at central sites first and then in surrounding habitats, (2) decrease with increasing distance away from their shelter site, and (3) extend to greater distances when prey patches are spaced closer together. Approximately 40% of lionfish exhibited short-term crepuscular foraging movements into surrounding habitats from the coral patch reefs where they shelter during daylight hours. Over the course of 7 weeks, lionfish depleted native fish populations on the coral patch reefs where they reside, and subsequently on small structures in the surrounding habitat. However, their effects did not decrease with increasing distance from the central shelter site and the influence of patch spacing was opposite the prediction. Instead, lionfish always had the greatest effects in areas with the highest prey densities. The differences between the predicted and observed effects of lionfish foraging are likely due to different constraints faced by invasive predators compared to native predators, namely that lionfish do not face increased predation risk with increased movement away from shelter sites. By foraging at greater distances from patch reefs than native predators, lionfish eliminated a spatial refuge from predation used by juveniles of many commercially and ecologically important reef fishes. © 2016 by the Ecological Society of America.

  3. Sediment size of surface floodplain sediments along a large lowland river

    NASA Astrophysics Data System (ADS)

    Swanson, K. M.; Day, G.; Dietrich, W. E.

    2007-12-01

    Data on size distribution of surface sediment across a floodplain should place important constraints of modeling of floodplain deposition. Diffusive or advective models would predict that, generally, grain size should decrease away from channel banks. Variations in grain size downstream along floodplains may depend on downstream fining of river bed material, exchange rate with river banks and net deposition onto the floodplain. Here we report detailed grain size analyses taken from 17 floodplain transects along 450 km (along channel distance) reach of the middle Fly River, Papua New Guinea. Field studies have documented a systematic change in floodplain characteristics downstream from forested, more topographically elevated and topography bounded by an actively shifting mainstem channel to a downstream swamp grass, low elevation topography along which the river meanders are currently stagnant. Frequency and duration of flooding increase downstream. Flooding occurs both by overbank flows and by injections of floodwaters up tributary and tie channels connected to the mainstem. Previous studies show that about 40% of the total discharge of water passes across the floodplain, and, correspondingly, about 40% of the total load is deposited on the plain - decreasing exponentially from channel bank. We find that floodplain sediment is most sandy at the channel bank. Grain size rapidly declines away from the bank, but surprisingly two trends were also observed. A relatively short distance from the bank the surface material is finest, but with further distance from the bank (out to greater than 1 km from the 250 m wide channel) clay content decreases and silt content increases. The changes are small but repeated at most of the transects. The second trend is that bank material fines downstream, corresponding to a downstream finding bed material, but once away from the bank, there is a weak tendency for a given distance away from the bank the floodplain surface deposits to slightly coarsen downstream. We also find that sand is present (about 4%) in these surface sediments out to 1 km from the channel bank. These trends are not consistent with simple lateral transport models, and other factors, including effects of flocculation, local flow patterns, and possibly dry season wind effects may matter.

  4. The 1% concordance Hubble constant

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bennett, C. L.; Larson, D.; Weiland, J. L.

    2014-10-20

    The determination of the Hubble constant has been a central goal in observational astrophysics for nearly a hundred years. Extraordinary progress has occurred in recent years on two fronts: the cosmic distance ladder measurements at low redshift and cosmic microwave background (CMB) measurements at high redshift. The CMB is used to predict the current expansion rate through a best-fit cosmological model. Complementary progress has been made with baryon acoustic oscillation (BAO) measurements at relatively low redshifts. While BAO data do not independently determine a Hubble constant, they are important for constraints on possible solutions and checks on cosmic consistency. Amore » precise determination of the Hubble constant is of great value, but it is more important to compare the high and low redshift measurements to test our cosmological model. Significant tension would suggest either uncertainties not accounted for in the experimental estimates or the discovery of new physics beyond the standard model of cosmology. In this paper we examine in detail the tension between the CMB, BAO, and cosmic distance ladder data sets. We find that these measurements are consistent within reasonable statistical expectations and we combine them to determine a best-fit Hubble constant of 69.6 ± 0.7 km s{sup –1} Mpc{sup –1}. This value is based upon WMAP9+SPT+ACT+6dFGS+BOSS/DR11+H {sub 0}/Riess; we explore alternate data combinations in the text. The combined data constrain the Hubble constant to 1%, with no compelling evidence for new physics.« less

  5. Exocomet Orbit Fitting: Accelerating Coma Absorption During Transits of β Pictoris

    NASA Astrophysics Data System (ADS)

    Kennedy, Grant M.

    2018-06-01

    Comets are a remarkable feature in our night sky, visible on their passage through the inner Solar system as the Sun's energy sublimates ices and liberates surface material, generating beautiful comae, dust, and ion tails. Comets are also thought to orbit other stars, and are the most promising interpretation of sporadic absorption features (i.e. transits) seen in spectra of stars such as β Pictoris and 49 Ceti. These "exocomets" are thought to form and evolve in the same way as in the Solar system, and as in the Solar system we may gain insight into their origins by deriving their orbits. In the case of β Pictoris, orbits have been estimated indirectly, using the radial velocity of the absorption features coupled with a physical evaporation model to estimate the stellocentric distance at transit dtr. Here, we note that the inferred dtr imply that some absorption signatures should accelerate over several hours, and show that this acceleration is indeed seen in HARPS spectra. This new constraint means that orbital characteristics can be obtained directly, and the pericentre distance and longitude constrained when parabolic orbits are assumed. The results from fitting orbits to 12 accelerating features, and a handful of non-accelerating ones, are in broad agreement with previous estimates based on an evaporation model, thereby providing some validation of the exocomet hypothesis. A prediction of the evaporation model, that coma absorption is deeper for more distant transits, is also seen here.

  6. Improving single-molecule FRET measurements by confining molecules in nanopipettes

    NASA Astrophysics Data System (ADS)

    Vogelsang, J.; Doose, S.; Sauer, M.; Tinnefeld, P.

    2007-07-01

    In recent years Fluorescence Resonance Energy Transfer (FRET) has been widely used to determine distances, observe distance dynamics, and monitor molecular binding at the single-molecule level. A basic constraint of single-molecule FRET studies is the limited distance resolution owing to low photon statistics. We demonstrate that by confining molecules in nanopipettes (50-100 nm diameter) smFRET can be measured with improved photon statistics reducing the width of FRET proximity ratio distributions (PRD). This increase in distance resolution makes it possible to reveal subpopulations and dynamics in biomolecular complexes. Our data indicate that the width of PRD is not only determined by photon statistics (shot noise) and distance distributions between the chromophores but that photoinduced dark states of the acceptor also contribute to the PRD width. Furthermore, acceptor dark states such as triplet states influence the accuracy of determined mean FRET values. In this context, we present a strategy for the correction of the shift of the mean PR that is related to triplet induced blinking of the acceptor using reference FCS measurements.

  7. Can an Excellent Distance Learning Library Service Support Student Retention and How Can We Find out?

    ERIC Educational Resources Information Center

    Needham, Gill; Nurse, Richard; Parker, Jo; Scantlebury, Non; Dick, Sam

    2013-01-01

    Higher education libraries have traditionally sought to be able to demonstrate the impact their services have on student attainment. This is particularly important in the current economic climate where libraries frequently have to defend their budgets in the face of financial constraints, whilst needing to demonstrate better value for money to…

  8. Development and Evaluation of Ning Social Network for Teaching Training Online Surveillance

    ERIC Educational Resources Information Center

    Mohd Nawi, Mohd Aliff; Jamsari, Ezad Azraai; Sulaiman, Adibah; Hamzah, Mohd Isa

    2013-01-01

    Supervision of teaching practice is an important aspect of training teachers in improving their teaching skills. Barriers such as distance and time factor are the constraints faced by the lecturers at the National University of Malaysia to communicate with the teacher trainees under their supervision. Therefore, this study aims to develop and…

  9. Regional Attenuation at PIDC Stations and the Transportability of the S/P Discriminant

    DTIC Science & Technology

    1998-03-31

    amplitude ratios using a variety of frequency bands subject to the constraint that the P-wave frequency is greater than or equal to the 5 - wave frequency... the 5 - wave frequency. First, we discuss our distance and source corrections and show that we were able to remove these dependencies in the data

  10. Lagrangian acceleration statistics in a turbulent channel flow

    NASA Astrophysics Data System (ADS)

    Stelzenmuller, Nickolas; Polanco, Juan Ignacio; Vignal, Laure; Vinkovic, Ivana; Mordant, Nicolas

    2017-05-01

    Lagrangian acceleration statistics in a fully developed turbulent channel flow at Reτ=1440 are investigated, based on tracer particle tracking in experiments and direct numerical simulations. The evolution with wall distance of the Lagrangian velocity and acceleration time scales is analyzed. Dependency between acceleration components in the near-wall region is described using cross-correlations and joint probability density functions. The strong streamwise coherent vortices typical of wall-bounded turbulent flows are shown to have a significant impact on the dynamics. This results in a strong anisotropy at small scales in the near-wall region that remains present in most of the channel. Such statistical properties may be used as constraints in building advanced Lagrangian stochastic models to predict the dispersion and mixing of chemical components for combustion or environmental studies.

  11. Nuclear constraints on the age of the universe

    NASA Technical Reports Server (NTRS)

    Schramm, D. N.

    1982-01-01

    A review is made of how one can use nuclear physics to put rather stringent limits on the age of the universe and thus the cosmic distance scale. The age can be estimated to a fair degree of accuracy. No single measurement of the time since the Big Bang gives a specific, unambiguous age. There are several methods that together fix the age with surprising precision. In particular, there are three totally independent techniques for estimating an age and a fourth technique which involves finding consistency of the other three in the framework of the standard Big Bang cosmological model. The three independent methods are: cosmological dynamics, the age of the oldest stars, and radioactive dating. This paper concentrates on the third of the three methods, and the consistency technique.

  12. An integrated collision prediction and avoidance scheme for mobile robots in non-stationary environments

    NASA Technical Reports Server (NTRS)

    Kyriakopoulos, K. J.; Saridis, G. N.

    1993-01-01

    A formulation that makes possible the integration of collision prediction and avoidance stages for mobile robots moving in general terrains containing moving obstacles is presented. A dynamic model of the mobile robot and the dynamic constraints are derived. Collision avoidance is guaranteed if the distance between the robot and a moving obstacle is nonzero. A nominal trajectory is assumed to be known from off-line planning. The main idea is to change the velocity along the nominal trajectory so that collisions are avoided. A feedback control is developed and local asymptotic stability is proved if the velocity of the moving obstacle is bounded. Furthermore, a solution to the problem of inverse dynamics for the mobile robot is given. Simulation results verify the value of the proposed strategy.

  13. Fermi Observations of High-Energy Gamma-Ray Emission from GRB 080916C

    DOE PAGES

    Abdo, A. A.; Ackermann, M.; Arimoto, M.; ...

    2009-02-19

    Gamma-ray bursts (GRBs) are highly energetic explosions signaling the death of massive stars in distant galaxies. The Gamma-ray Burst Monitor and Large Area Telescope onboard the Fermi Observatory together record GRBs over a broad energy range spanning about 7 decades of gammaray energy. In September 2008, Fermi observed the exceptionally luminous GRB 080916C, with the largest apparent energy release yet measured. The high-energy gamma rays are observed to start later and persist longer than the lower energy photons. A simple spectral form fits the entire GRB spectrum, providing strong constraints on emission models. Finally, the known distance of the burstmore » enables placing lower limits on the bulk Lorentz factor of the outflow and on the quantum gravity mass.« less

  14. The exit-time problem for a Markov jump process

    NASA Astrophysics Data System (ADS)

    Burch, N.; D'Elia, M.; Lehoucq, R. B.

    2014-12-01

    The purpose of this paper is to consider the exit-time problem for a finite-range Markov jump process, i.e, the distance the particle can jump is bounded independent of its location. Such jump diffusions are expedient models for anomalous transport exhibiting super-diffusion or nonstandard normal diffusion. We refer to the associated deterministic equation as a volume-constrained nonlocal diffusion equation. The volume constraint is the nonlocal analogue of a boundary condition necessary to demonstrate that the nonlocal diffusion equation is well-posed and is consistent with the jump process. A critical aspect of the analysis is a variational formulation and a recently developed nonlocal vector calculus. This calculus allows us to pose nonlocal backward and forward Kolmogorov equations, the former equation granting the various moments of the exit-time distribution.

  15. Using GIS for Developing Sustainable Urban Growth Case Kyrenia Region

    NASA Astrophysics Data System (ADS)

    Kara, C.; Akçit, N.

    2018-03-01

    It is critical to develop urban layers for analysis sustainable urban development possibilities within planning process. Kyrenia Region has many physical, environmental or economic issues that may danger the growth possibilities in sustainable manner. From this point, this study uses different spatial layers such as slope, distance to roads, distance to central zone, vegetation, soil productivity, environmental protection zones, distance to open/green space, distance to education for supporting sustainable urban growth policies and define suitable areas for urban development within this perspective. The study tries to convert sustainable urban growth policies such as; compact growth, environmental protection, equal accessibility to basic services; into spatial layers and establish proper framework for multi criteria evaluation in Kyrenia Region within using geographical information systems. It shows suitability values for Kyrenia region and constraints zones at final section. It clearly presents the suitable areas for the sustainable urbanization and also unsuitable or risky areas for reducing the possible disasters and may happen in the future.

  16. Size and shape in Melipona quadrifasciata anthidioides Lepeletier, 1836 (Hymenoptera; Meliponini).

    PubMed

    Nunes, L A; Passos, G B; Carvalho, C A L; Araújo, E D

    2013-11-01

    This study aimed to identify differences in wing shape among populations of Melipona quadrifasciata anthidioides obtained in 23 locations in the semi-arid region of Bahia state (Brazil). Analysis of the Procrustes distances among mean wing shapes indicated that population structure did not determine shape variation. Instead, populations were structured geographically according to wing size. The Partial Mantel Test between morphometric (shape and size) distance matrices and altitude, taking geographic distances into account, was used for a more detailed understanding of size and shape determinants. A partial Mantel test between morphometris (shape and size) variation and altitude, taking geographic distances into account, revealed that size (but not shape) is largely influenced by altitude (r = 0.54 p < 0.01). These results indicate greater evolutionary constraints for the shape variation, which must be directly associated with aerodynamic issues in this structure. The size, however, indicates that the bees tend to have larger wings in populations located at higher altitudes.

  17. Constraint Logic Programming approach to protein structure prediction.

    PubMed

    Dal Palù, Alessandro; Dovier, Agostino; Fogolari, Federico

    2004-11-30

    The protein structure prediction problem is one of the most challenging problems in biological sciences. Many approaches have been proposed using database information and/or simplified protein models. The protein structure prediction problem can be cast in the form of an optimization problem. Notwithstanding its importance, the problem has very seldom been tackled by Constraint Logic Programming, a declarative programming paradigm suitable for solving combinatorial optimization problems. Constraint Logic Programming techniques have been applied to the protein structure prediction problem on the face-centered cube lattice model. Molecular dynamics techniques, endowed with the notion of constraint, have been also exploited. Even using a very simplified model, Constraint Logic Programming on the face-centered cube lattice model allowed us to obtain acceptable results for a few small proteins. As a test implementation their (known) secondary structure and the presence of disulfide bridges are used as constraints. Simplified structures obtained in this way have been converted to all atom models with plausible structure. Results have been compared with a similar approach using a well-established technique as molecular dynamics. The results obtained on small proteins show that Constraint Logic Programming techniques can be employed for studying protein simplified models, which can be converted into realistic all atom models. The advantage of Constraint Logic Programming over other, much more explored, methodologies, resides in the rapid software prototyping, in the easy way of encoding heuristics, and in exploiting all the advances made in this research area, e.g. in constraint propagation and its use for pruning the huge search space.

  18. Updating the MACHO fraction of the Milky Way dark halo with improved mass models

    NASA Astrophysics Data System (ADS)

    Calcino, Josh; García-Bellido, Juan; Davis, Tamara M.

    2018-05-01

    Recent interest in primordial black holes as a possible dark matter candidate has motivated the reanalysis of previous methods for constraining massive astrophysical compact objects in the Milky Way halo and beyond. In order to derive these constraints, a model for the dark matter distribution around the Milky Way must be used. Previous microlensing searches have assumed a semi-isothermal density sphere for this task. We show this model is no longer consistent with data from the Milky Way rotation curve, and test two replacement models, namely NFW and power-law. The power-law model is the most flexible as it can break spherical symmetry, and best fits the data. Thus, we recommend the power-law model as a replacement, although it still lacks the flexibility to fully encapsulate all possible shapes of the Milky Way halo. We then use the power-law model to rederive some previous microlensing constraints in the literature, while propagating the primary halo-shape uncertainties through to our final constraints. Our analysis reveals that the microlensing constraints towards the Large Magellanic Cloud weaken somewhat for MACHO masses around 10 M⊙ when this uncertainty is taken into account, but the constraints tighten at lower masses. Exploring some of the simplifying assumptions of previous constraints we also study the effect of wide mass distributions of compact halo objects, as well as the effect of spatial clustering on microlensing constraints. We find that both effects induce a shift in the constraints towards smaller masses, and can effectively remove the microlensing constraints from M ˜ 1 - 10M⊙ for certain MACHO populations.

  19. Robust Design Optimization via Failure Domain Bounding

    NASA Technical Reports Server (NTRS)

    Crespo, Luis G.; Kenny, Sean P.; Giesy, Daniel P.

    2007-01-01

    This paper extends and applies the strategies recently developed by the authors for handling constraints under uncertainty to robust design optimization. For the scope of this paper, robust optimization is a methodology aimed at problems for which some parameters are uncertain and are only known to belong to some uncertainty set. This set can be described by either a deterministic or a probabilistic model. In the methodology developed herein, optimization-based strategies are used to bound the constraint violation region using hyper-spheres and hyper-rectangles. By comparing the resulting bounding sets with any given uncertainty model, it can be determined whether the constraints are satisfied for all members of the uncertainty model (i.e., constraints are feasible) or not (i.e., constraints are infeasible). If constraints are infeasible and a probabilistic uncertainty model is available, upper bounds to the probability of constraint violation can be efficiently calculated. The tools developed enable approximating not only the set of designs that make the constraints feasible but also, when required, the set of designs for which the probability of constraint violation is below a prescribed admissible value. When constraint feasibility is possible, several design criteria can be used to shape the uncertainty model of performance metrics of interest. Worst-case, least-second-moment, and reliability-based design criteria are considered herein. Since the problem formulation is generic and the tools derived only require standard optimization algorithms for their implementation, these strategies are easily applicable to a broad range of engineering problems.

  20. Radial vorticity constraint in core flow modeling

    NASA Astrophysics Data System (ADS)

    Asari, S.; Lesur, V.

    2011-11-01

    We present a new method for estimating core surface flows by relaxing the tangentially geostrophic (TG) constraint. Ageostrophic flows are allowed if they are consistent with the radial component of the vorticity equation under assumptions of the magnetostrophic force balance and an insulating mantle. We thus derive a tangentially magnetostrophic (TM) constraint for flows in the spherical harmonic domain and implement it in a least squares inversion of GRIMM-2, a recently proposed core field model, for temporally continuous core flow models (2000.0-2010.0). Comparing the flows calculated using the TG and TM constraints, we show that the number of degrees of freedom for the poloidal flows is notably increased by admitting ageostrophic flows compatible with the TM constraint. We find a significantly improved fit to the GRIMM-2 secular variation (SV) by including zonal poloidal flow in TM flow models. Correlations between the predicted and observed length-of-day variations are equally good under the TG and TM constraints. In addition, we estimate flow models by imposing the TM constraint together with other dynamical constraints: either purely toroidal (PT) flow or helical flow constraint. For the PT case we cannot find any flow which explains the observed SV, while for the helical case the SV can be fitted. The poor compatibility between the TM and PT constraints seems to arise from the absence of zonal poloidal flows. The PT flow assumption is likely to be negated when the radial magnetostrophic vorticity balance is taken into account, even if otherwise consistent with magnetic observations.

  1. Adhesion and volume constraints via nonlocal interactions determine cell organisation and migration profiles.

    PubMed

    Carrillo, José Antonio; Colombi, Annachiara; Scianna, Marco

    2018-05-14

    The description of the cell spatial pattern and characteristic distances is fundamental in a wide range of physio-pathological biological phenomena, from morphogenesis to cancer growth. Discrete particle models are widely used in this field, since they are focused on the cell-level of abstraction and are able to preserve the identity of single individuals reproducing their behavior. In particular, a fundamental role in determining the usefulness and the realism of a particle mathematical approach is played by the choice of the intercellular pairwise interaction kernel and by the estimate of its parameters. The aim of the paper is to demonstrate how the concept of H-stability, deriving from statistical mechanics, can have important implications in this respect. For any given interaction kernel, it in fact allows to a priori predict the regions of the free parameter space that result in stable configurations of the system characterized by a finite and strictly positive minimal interparticle distance, which is fundamental when dealing with biological phenomena. The proposed analytical arguments are indeed able to restrict the range of possible variations of selected model coefficients, whose exact estimate however requires further investigations (e.g., fitting with empirical data), as illustrated in this paper by series of representative simulations dealing with cell colony reorganization, sorting phenomena and zebrafish embryonic development. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  2. Percolation of spatially constrained Erdős-Rényi networks with degree correlations.

    PubMed

    Schmeltzer, C; Soriano, J; Sokolov, I M; Rüdiger, S

    2014-01-01

    Motivated by experiments on activity in neuronal cultures [ J. Soriano, M. Rodríguez Martínez, T. Tlusty and E. Moses Proc. Natl. Acad. Sci. 105 13758 (2008)], we investigate the percolation transition and critical exponents of spatially embedded Erdős-Rényi networks with degree correlations. In our model networks, nodes are randomly distributed in a two-dimensional spatial domain, and the connection probability depends on Euclidian link length by a power law as well as on the degrees of linked nodes. Generally, spatial constraints lead to higher percolation thresholds in the sense that more links are needed to achieve global connectivity. However, degree correlations favor or do not favor percolation depending on the connectivity rules. We employ two construction methods to introduce degree correlations. In the first one, nodes stay homogeneously distributed and are connected via a distance- and degree-dependent probability. We observe that assortativity in the resulting network leads to a decrease of the percolation threshold. In the second construction methods, nodes are first spatially segregated depending on their degree and afterwards connected with a distance-dependent probability. In this segregated model, we find a threshold increase that accompanies the rising assortativity. Additionally, when the network is constructed in a disassortative way, we observe that this property has little effect on the percolation transition.

  3. Functional connectivity in replicated urban landscapes in the land snail (Cornu aspersum).

    PubMed

    Balbi, Manon; Ernoult, Aude; Poli, Pedro; Madec, Luc; Guiller, Annie; Martin, Marie-Claire; Nabucet, Jean; Beaujouan, Véronique; Petit, Eric J

    2018-03-01

    Urban areas are highly fragmented and thereby exert strong constraints on individual dispersal. Despite this, some species manage to persist in urban areas, such as the garden snail, Cornu aspersum, which is common in cityscapes despite its low mobility. Using landscape genetic approaches, we combined study area replication and multiscale analysis to determine how landscape composition, configuration and connectivity influence snail dispersal across urban areas. At the overall landscape scale, areas with a high percentage of roads decreased genetic differentiation between populations. At the population scale, genetic differentiation was positively linked with building surface, the proportion of borders where wooded patches and roads appeared side by side and the proportion of borders combining wooded patches and other impervious areas. Analyses based on pairwise genetic distances validated the isolation-by-distance and isolation-by-resistance models for this land snail, with an equal fit to least-cost paths and circuit-theory-based models. Each of the 12 landscapes analysed separately yielded specific relations to environmental features, whereas analyses integrating all replicates highlighted general common effects. Our results suggest that urban transport infrastructures facilitate passive snail dispersal. At a local scale, corresponding to active dispersal, unfavourable habitats (wooded and impervious areas) isolate populations. This work upholds the use of replicated landscapes to increase the generalizability of landscape genetics results and shows how multiscale analyses provide insight into scale-dependent processes. © 2018 John Wiley & Sons Ltd.

  4. A multiscale approach to simulating the conformational properties of unbound multi-C₂H₂ zinc finger proteins.

    PubMed

    Liu, Lei; Wade, Rebecca C; Heermann, Dieter W

    2015-09-01

    The conformational properties of unbound multi-Cys2 His2 (mC2H2) zinc finger proteins, in which zinc finger domains are connected by flexible linkers, are studied by a multiscale approach. Three methods on different length scales are utilized. First, atomic detail molecular dynamics simulations of one zinc finger and its adjacent flexible linker confirmed that the zinc finger is more rigid than the flexible linker. Second, the end-to-end distance distributions of mC2H2 zinc finger proteins are computed using an efficient atomistic pivoting algorithm, which only takes excluded volume interactions into consideration. The end-to-end distance distribution gradually changes its profile, from left-tailed to right-tailed, as the number of zinc fingers increases. This is explained by using a worm-like chain model. For proteins of a few zinc fingers, an effective bending constraint favors an extended conformation. Only for proteins containing more than nine zinc fingers, is a somewhat compacted conformation preferred. Third, a mesoscale model is modified to study both the local and the global conformational properties of multi-C2H2 zinc finger proteins. Simulations of the CCCTC-binding factor (CTCF), an important mC2H2 zinc finger protein for genome spatial organization, are presented. © 2015 Wiley Periodicals, Inc.

  5. Dynamical constraints on the dark matter distribution in the Milky Way

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pato, Miguel; Iocco, Fabio; Bertone, Gianfranco, E-mail: migpato@gmail.com, E-mail: fabio.iocco.astro@gmail.com, E-mail: g.bertone@uva.nl

    2015-12-01

    An accurate knowledge of the dark matter distribution in the Milky Way is of crucial importance for galaxy formation studies and current searches for particle dark matter. In this paper we set new dynamical constraints on the Galactic dark matter profile by comparing the observed rotation curve, updated with a comprehensive compilation of kinematic tracers, with that inferred from a wide range of observation-based morphologies of the bulge, disc and gas. The generalised Navarro-Frenk-White (NFW) and Einasto dark matter profiles are fitted to the data in order to determine the favoured ranges of local density, slope and scale radius. Formore » a representative baryonic model, a typical local circular velocity v{sub 0}=230 km/s and a distance of the Sun to the Galactic centre R{sub 0}=8 kpc, we find a local dark matter density ρ{sub 0} = 0.420{sup +0.021}{sub −0.018} (2σ) ± 0.025 GeV/cm{sup 3} (ρ{sub 0} = 0.420{sup +0.019}{sub −0.021} (2σ) ± 0.026 GeV/cm{sup 3}) for NFW (Einasto), where the second error is an estimate of the systematic due to baryonic modelling. Apart from the Galactic parameters, the main sources of uncertainty inside and outside the solar circle are baryonic modelling and rotation curve measurements, respectively. Upcoming astronomical observations are expected to reduce all these uncertainties substantially over the coming years.« less

  6. Constraints on the sum of neutrino masses using cosmological data including the latest extended Baryon Oscillation Spectroscopic Survey DR14 quasar sample

    NASA Astrophysics Data System (ADS)

    Wang, Sai; Wang, Yi-Fan; Xia, Dong-Mei

    2018-05-01

    We investigate the constraints on the sum of neutrino masses ({{Σ }}{m}ν ) using the most recent cosmological data, which combines the distance measurement from baryonic acoustic oscillation in the extended Baryon Oscillation Spectroscopic Survey DR14 quasar sample with the power spectra of temperature and polarization anisotropies in the cosmic microwave background from the Planck 2015 data release. We also use other low-redshift observations, including the baryonic acoustic oscillation at relatively low redshifts, Type Ia supernovae, and the local measurement of the Hubble constant. In the standard cosmological constant Λ cold dark matter plus massive neutrino model, we obtain the 95% upper limit to be {{Σ }}{m}ν < 0.129{eV} for the degenerate mass hierarchy, {{Σ }}{m}ν < 0.159{eV} for the normal mass hierarchy, and {{Σ }}{m}ν < 0.189{eV} for the inverted mass hierarchy. Based on Bayesian evidence, we find that the degenerate hierarchy is positively supported, and the current data combination cannot distinguish between normal and inverted hierarchies. Assuming the degenerate mass hierarchy, we extend our study to non-standard cosmological models including generic dark energy, spatial curvature, and extra relativistic degrees of freedom, but find these models are not favored by the data. SW is Supported by a grant from the Research Grant Council of the Hong Kong Special Administrative Region, China (14301214), DMX is Supported by the National Natural Science Foundation of China (11505018) and the Chongqing Science and Technology Plan Project (Cstc2015jvyj40031)

  7. An implicit adaptation algorithm for a linear model reference control system

    NASA Technical Reports Server (NTRS)

    Mabius, L.; Kaufman, H.

    1975-01-01

    This paper presents a stable implicit adaptation algorithm for model reference control. The constraints for stability are found using Lyapunov's second method and do not depend on perfect model following between the system and the reference model. Methods are proposed for satisfying these constraints without estimating the parameters on which the constraints depend.

  8. Statistical Techniques to Explore the Quality of Constraints in Constraint-Based Modeling Environments

    ERIC Educational Resources Information Center

    Gálvez, Jaime; Conejo, Ricardo; Guzmán, Eduardo

    2013-01-01

    One of the most popular student modeling approaches is Constraint-Based Modeling (CBM). It is an efficient approach that can be easily applied inside an Intelligent Tutoring System (ITS). Even with these characteristics, building new ITSs requires carefully designing the domain model to be taught because different sources of errors could affect…

  9. Source term identification in atmospheric modelling via sparse optimization

    NASA Astrophysics Data System (ADS)

    Adam, Lukas; Branda, Martin; Hamburger, Thomas

    2015-04-01

    Inverse modelling plays an important role in identifying the amount of harmful substances released into atmosphere during major incidents such as power plant accidents or volcano eruptions. Another possible application of inverse modelling lies in the monitoring the CO2 emission limits where only observations at certain places are available and the task is to estimate the total releases at given locations. This gives rise to minimizing the discrepancy between the observations and the model predictions. There are two standard ways of solving such problems. In the first one, this discrepancy is regularized by adding additional terms. Such terms may include Tikhonov regularization, distance from a priori information or a smoothing term. The resulting, usually quadratic, problem is then solved via standard optimization solvers. The second approach assumes that the error term has a (normal) distribution and makes use of Bayesian modelling to identify the source term. Instead of following the above-mentioned approaches, we utilize techniques from the field of compressive sensing. Such techniques look for a sparsest solution (solution with the smallest number of nonzeros) of a linear system, where a maximal allowed error term may be added to this system. Even though this field is a developed one with many possible solution techniques, most of them do not consider even the simplest constraints which are naturally present in atmospheric modelling. One of such examples is the nonnegativity of release amounts. We believe that the concept of a sparse solution is natural in both problems of identification of the source location and of the time process of the source release. In the first case, it is usually assumed that there are only few release points and the task is to find them. In the second case, the time window is usually much longer than the duration of the actual release. In both cases, the optimal solution should contain a large amount of zeros, giving rise to the concept of sparsity. In the paper, we summarize several optimization techniques which are used for finding sparse solutions and propose their modifications to handle selected constraints such as nonnegativity constraints and simple linear constraints, for example the minimal or maximal amount of total release. These techniques range from successive convex approximations to solution of one nonconvex problem. On simple examples, we explain these techniques and compare them from the point of implementation simplicity, approximation capability and convergence properties. Finally, these methods will be applied on the European Tracer Experiment (ETEX) data and the results will be compared with the current state of arts techniques such as regularized least squares or Bayesian approach. The obtained results show the surprisingly good results of these techniques. This research is supported by EEA/Norwegian Financial Mechanism under project 7F14287 STRADI.

  10. Two-dimensional probabilistic inversion of plane-wave electromagnetic data: methodology, model constraints and joint inversion with electrical resistivity data

    NASA Astrophysics Data System (ADS)

    Rosas-Carbajal, Marina; Linde, Niklas; Kalscheuer, Thomas; Vrugt, Jasper A.

    2014-03-01

    Probabilistic inversion methods based on Markov chain Monte Carlo (MCMC) simulation are well suited to quantify parameter and model uncertainty of nonlinear inverse problems. Yet, application of such methods to CPU-intensive forward models can be a daunting task, particularly if the parameter space is high dimensional. Here, we present a 2-D pixel-based MCMC inversion of plane-wave electromagnetic (EM) data. Using synthetic data, we investigate how model parameter uncertainty depends on model structure constraints using different norms of the likelihood function and the model constraints, and study the added benefits of joint inversion of EM and electrical resistivity tomography (ERT) data. Our results demonstrate that model structure constraints are necessary to stabilize the MCMC inversion results of a highly discretized model. These constraints decrease model parameter uncertainty and facilitate model interpretation. A drawback is that these constraints may lead to posterior distributions that do not fully include the true underlying model, because some of its features exhibit a low sensitivity to the EM data, and hence are difficult to resolve. This problem can be partly mitigated if the plane-wave EM data is augmented with ERT observations. The hierarchical Bayesian inverse formulation introduced and used herein is able to successfully recover the probabilistic properties of the measurement data errors and a model regularization weight. Application of the proposed inversion methodology to field data from an aquifer demonstrates that the posterior mean model realization is very similar to that derived from a deterministic inversion with similar model constraints.

  11. Extragalactic Ultra-High Energy Cosmic-Rays - Part One - Contribution from Hot Spots in Fr-II Radio Galaxies

    NASA Astrophysics Data System (ADS)

    Rachen, J. P.; Biermann, P. L.

    1993-05-01

    The hot spots of Fanaroff-Riley class II radio galaxies, considered as working surfaces of highly collimated plasma jets, are proposed to be the dominant sources of the cosmic rays at energies above 1 EeV^a^. We apply the model of first order Fermi acceleration at strong, nonrelativistic shock waves to the hot spot region. The strength of the model has been demonstrated by Biermann & Strittmatter (1987) and by Meisenheimer et al. (1989), who explain their radio-to optical spectra and infer the physical conditions of the radiating plasma. Using synchrotron radiating electrons as a trace, we can calculate the spectrum and the maximum energy of protons accelerated under the same conditions. For simplicity, we disregard heavy nuclei, but their probable role is discussed. The normalization of proton flux injected in extragalactic space is performed by using estimates from Rawlings & Saunders (1991) for the total energy stored in relativistic particles inside the jets and radio galaxy evolution models given by Peacock (1985). We calculate the spectral modifications due to interactions of the protons with the microwave background photons in an evolving universe, following Berezinsky & Grigor'eva (1988). Constraints on the extragalactic magnetic field can be imposed, since it must permit an almost homogeneous filling of the universe with energetic protons. The observed ultra-high energy cosmic ray spectrum is reproduced in slope and flux, limited at high energies by the Greisen-cutoff at about 80 EeV. The requirements on the content of relativistic protons in jets and the constraints to the extragalactic magnetic field are consistent with common estimates. The data beyond the Greisen cutoff for protons may be explained by including heavy nuclei in our model, since they can propagate over cosmological distances up to more than 100 EeV.

  12. Separation-Compliant, Optimal Routing and Control of Scheduled Arrivals in a Terminal Airspace

    NASA Technical Reports Server (NTRS)

    Sadovsky, Alexander V.; Davis, Damek; Isaacson, Douglas R.

    2013-01-01

    We address the problem of navigating a set (fleet) of aircraft in an aerial route network so as to bring each aircraft to its destination at a specified time and with minimal distance separation assured between all aircraft at all times. The speed range, initial position, required destination, and required time of arrival at destination for each aircraft are assumed provided. Each aircraft's movement is governed by a controlled differential equation (state equation). The problem consists in choosing for each aircraft a path in the route network and a control strategy so as to meet the constraints and reach the destination at the required time. The main contribution of the paper is a model that allows to recast this problem as a decoupled collection of problems in classical optimal control and is easily generalized to the case when inertia cannot be neglected. Some qualitative insight into solution behavior is obtained using the Pontryagin Maximum Principle. Sample numerical solutions are computed using a numerical optimal control solver. The proposed model is first step toward increasing the fidelity of continuous time control models of air traffic in a terminal airspace. The Pontryagin Maximum Principle implies the polygonal shape of those portions of the state trajectories away from those states in which one or more aircraft pair are at minimal separation. The model also confirms the intuition that, the narrower the allowed speed ranges of the aircraft, the smaller the space of optimal solutions, and that an instance of the optimal control problem may not have a solution at all (i.e., no control strategy that meets the separation requirement and other constraints).

  13. Temporal Constraint Reasoning With Preferences

    NASA Technical Reports Server (NTRS)

    Khatib, Lina; Morris, Paul; Morris, Robert; Rossi, Francesca

    2001-01-01

    A number of reasoning problems involving the manipulation of temporal information can naturally be viewed as implicitly inducing an ordering of potential local decisions involving time (specifically, associated with durations or orderings of events) on the basis of preferences. For example. a pair of events might be constrained to occur in a certain order, and, in addition. it might be preferable that the delay between them be as large, or as small, as possible. This paper explores problems in which a set of temporal constraints is specified, where each constraint is associated with preference criteria for making local decisions about the events involved in the constraint, and a reasoner must infer a complete solution to the problem such that, to the extent possible, these local preferences are met in the best way. A constraint framework for reasoning about time is generalized to allow for preferences over event distances and durations, and we study the complexity of solving problems in the resulting formalism. It is shown that while in general such problems are NP-hard, some restrictions on the shape of the preference functions, and on the structure of the preference set, can be enforced to achieve tractability. In these cases, a simple generalization of a single-source shortest path algorithm can be used to compute a globally preferred solution in polynomial time.

  14. Sliding mode control based impact angle control guidance considering the seeker׳s field-of-view constraint.

    PubMed

    Wang, Xingliang; Zhang, Youan; Wu, Huali

    2016-03-01

    The problem of impact angle control guidance for a field-of-view constrained missile against non-maneuvering or maneuvering targets is solved by using the sliding mode control theory. The existing impact angle control guidance laws with field-of-view constraint are only applicable against stationary targets and most of them suffer abrupt-jumping of guidance command due to the application of additional guidance mode switching logic. In this paper, the field-of-view constraint is handled without using any additional switching logic. In particular, a novel time-varying sliding surface is first designed to achieve zero miss distance and zero impact angle error without violating the field-of-view constraint during the sliding mode phase. Then a control integral barrier Lyapunov function is used to design the reaching law so that the sliding mode can be reached within finite time and the field-of-view constraint is not violated during the reaching phase as well. A nonlinear extended state observer is constructed to estimate the disturbance caused by unknown target maneuver, and the undesirable chattering is alleviated effectively by using the estimation as a compensation item in the guidance law. The performance of the proposed guidance law is illustrated with simulations. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

  15. Tune-stabilized, non-scaling, fixed-field, alternating gradient accelerator

    DOEpatents

    Johnstone, Carol J [Warrenville, IL

    2011-02-01

    A FFAG is a particle accelerator having turning magnets with a linear field gradient for confinement and a large edge angle to compensate for acceleration. FODO cells contain focus magnets and defocus magnets that are specified by a number of parameters. A set of seven equations, called the FFAG equations relate the parameters to one another. A set of constraints, call the FFAG constraints, constrain the FFAG equations. Selecting a few parameters, such as injection momentum, extraction momentum, and drift distance reduces the number of unknown parameters to seven. Seven equations with seven unknowns can be solved to yield the values for all the parameters and to thereby fully specify a FFAG.

  16. Some Physics Constraints on Ultimate Achievement in Track and Field

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Frohlich, Cliff

    2009-02-06

    World records in track and field have improved remarkably throughout the last 100 years; however, in several events physics places quite strict limitations on ultimate performance. For example, analysis suggests that records in broad jump and pole vault have approached their optimum possible values. Physical constraints are more subtle for events such as javelin, high jump, and the distance races, and thus there may be opportunities for “breakthroughs” in current records. Considering that there is enormous cultural interest and economic expenditure on sports, for most events the level of scientific analysis isn’t very high. This presents a research opportunity formore » fans who are engineers or physicists.« less

  17. a Robust Method for Stereo Visual Odometry Based on Multiple Euclidean Distance Constraint and Ransac Algorithm

    NASA Astrophysics Data System (ADS)

    Zhou, Q.; Tong, X.; Liu, S.; Lu, X.; Liu, S.; Chen, P.; Jin, Y.; Xie, H.

    2017-07-01

    Visual Odometry (VO) is a critical component for planetary robot navigation and safety. It estimates the ego-motion using stereo images frame by frame. Feature points extraction and matching is one of the key steps for robotic motion estimation which largely influences the precision and robustness. In this work, we choose the Oriented FAST and Rotated BRIEF (ORB) features by considering both accuracy and speed issues. For more robustness in challenging environment e.g., rough terrain or planetary surface, this paper presents a robust outliers elimination method based on Euclidean Distance Constraint (EDC) and Random Sample Consensus (RANSAC) algorithm. In the matching process, a set of ORB feature points are extracted from the current left and right synchronous images and the Brute Force (BF) matcher is used to find the correspondences between the two images for the Space Intersection. Then the EDC and RANSAC algorithms are carried out to eliminate mismatches whose distances are beyond a predefined threshold. Similarly, when the left image of the next time matches the feature points with the current left images, the EDC and RANSAC are iteratively performed. After the above mentioned, there are exceptional remaining mismatched points in some cases, for which the third time RANSAC is applied to eliminate the effects of those outliers in the estimation of the ego-motion parameters (Interior Orientation and Exterior Orientation). The proposed approach has been tested on a real-world vehicle dataset and the result benefits from its high robustness.

  18. Evaluation of bone surrogates for indirect and direct ballistic fractures.

    PubMed

    Bir, Cynthia; Andrecovich, Chris; DeMaio, Marlene; Dougherty, Paul J

    2016-04-01

    The mechanism of injury for fractures to long bones has been studied for both direct ballistic loading as well as indirect. However, the majority of these studies have been conducted on both post-mortem human subjects (PMHS) and animal surrogates which have constraints in terms of storage, preparation and testing. The identification of a validated bone surrogate for use in forensic, medical and engineering testing would provide the ability to investigate ballistic loading without these constraints. Two specific bone surrogates, Sawbones and Synbone, were evaluated in comparison to PMHS for both direct and indirect ballistic loading. For the direct loading, the mean velocity to produce fracture was 121 ± 19 m/s for the PMHS, which was statistically different from the Sawbones (140 ± 7 m/s) and Synbone (146 ± 3 m/s). The average distance to fracture in the indirect loading was .70 cm for the PMHS. The Synbone had a statistically similar average distance to fracture (.61 cm, p=0.54) however the Sawbones average distance to fracture was statistically different (.41 cm, p<0.05). Fractures patterns were found to be comparable to the PMHS for tests conducted with Synbones, however the input parameters were slightly varied to produce similar results. The fractures patterns with the Sawbones were not found to be as comparable to the PMHS. An ideal bone surrogate for ballistic testing was not identified and future work is warranted. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  19. The Problem of Hipparcos Distances to Open Clusters. Report 1; Constraints from Multicolor a Main-Sequence Fitting

    NASA Technical Reports Server (NTRS)

    Pinsonneault, Marc H.; Stauffer, John; Soderblom, David R.; King, Jeremy R.; Hanson, Robert B.

    1998-01-01

    Parallax data from the Hipparcos mission allow the direct distance to open clusters to be compared with the distance inferred from main-sequence (MS) fitting. There are surprising differences between the two distance measurements. indicating either the need for changes in the cluster compositions or reddening, underlying problems with the technique of MS fitting, or systematic errors in the Hipparcos parallaxes at the 1 mas level. We examine the different possibilities, focusing on MS fitting in both metallicity-sensitive B-V and metallicity-insensitive V-I for five well-studied systems (the Hyades, Pleiades, alpha Per, Praesepe, and Coma Ber). The Hipparcos distances to the Hyades and alpha Per are within 1 sigma of the MS-fitting distance in B-V and V-I, while the Hipparcos distances to Coma Ber and the Pleiades are in disagreement with the MS-fitting distance at more than the 3 sigma level. There are two Hipparcos measurements of the distance to Praesepe; one is in good agreement with the MS-fitting distance and the other disagrees at the 2 sigma level. The distance estimates from the different colors are in conflict with one another for Coma but in agreement for the Pleiades. Changes in the relative cluster metal abundances, age related effects, helium, and reddening are shown to be unlikely to explain the puzzling behavior of the Pleiades. We present evidence for spatially dependent systematic errors at the 1 mas level in the parallaxes of Pleiades stars. The implications of this result are discussed.

  20. Working memory differences in long-distance dependency resolution

    PubMed Central

    Nicenboim, Bruno; Vasishth, Shravan; Gattei, Carolina; Sigman, Mariano; Kliegl, Reinhold

    2015-01-01

    There is a wealth of evidence showing that increasing the distance between an argument and its head leads to more processing effort, namely, locality effects; these are usually associated with constraints in working memory (DLT: Gibson, 2000; activation-based model: Lewis and Vasishth, 2005). In SOV languages, however, the opposite effect has been found: antilocality (see discussion in Levy et al., 2013). Antilocality effects can be explained by the expectation-based approach as proposed by Levy (2008) or by the activation-based model of sentence processing as proposed by Lewis and Vasishth (2005). We report an eye-tracking and a self-paced reading study with sentences in Spanish together with measures of individual differences to examine the distinction between expectation- and memory-based accounts, and within memory-based accounts the further distinction between DLT and the activation-based model. The experiments show that (i) antilocality effects as predicted by the expectation account appear only for high-capacity readers; (ii) increasing dependency length by interposing material that modifies the head of the dependency (the verb) produces stronger facilitation than increasing dependency length with material that does not modify the head; this is in agreement with the activation-based model but not with the expectation account; and (iii) a possible outcome of memory load on low-capacity readers is the increase in regressive saccades (locality effects as predicted by memory-based accounts) or, surprisingly, a speedup in the self-paced reading task; the latter consistent with good-enough parsing (Ferreira et al., 2002). In sum, the study suggests that individual differences in working memory capacity play a role in dependency resolution, and that some of the aspects of dependency resolution can be best explained with the activation-based model together with a prediction component. PMID:25852623

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