Windows .NET Network Distributed Basic Local Alignment Search Toolkit (W.ND-BLAST)

PubMed Central

Dowd, Scot E; Zaragoza, Joaquin; Rodriguez, Javier R; Oliver, Melvin J; Payton, Paxton R

2005-01-01

Background BLAST is one of the most common and useful tools for Genetic Research. This paper describes a software application we have termed Windows .NET Distributed Basic Local Alignment Search Toolkit (W.ND-BLAST), which enhances the BLAST utility by improving usability, fault recovery, and scalability in a Windows desktop environment. Our goal was to develop an easy to use, fault tolerant, high-throughput BLAST solution that incorporates a comprehensive BLAST result viewer with curation and annotation functionality. Results W.ND-BLAST is a comprehensive Windows-based software toolkit that targets researchers, including those with minimal computer skills, and provides the ability increase the performance of BLAST by distributing BLAST queries to any number of Windows based machines across local area networks (LAN). W.ND-BLAST provides intuitive Graphic User Interfaces (GUI) for BLAST database creation, BLAST execution, BLAST output evaluation and BLAST result exportation. This software also provides several layers of fault tolerance and fault recovery to prevent loss of data if nodes or master machines fail. This paper lays out the functionality of W.ND-BLAST. W.ND-BLAST displays close to 100% performance efficiency when distributing tasks to 12 remote computers of the same performance class. A high throughput BLAST job which took 662.68 minutes (11 hours) on one average machine was completed in 44.97 minutes when distributed to 17 nodes, which included lower performance class machines. Finally, there is a comprehensive high-throughput BLAST Output Viewer (BOV) and Annotation Engine components, which provides comprehensive exportation of BLAST hits to text files, annotated fasta files, tables, or association files. Conclusion W.ND-BLAST provides an interactive tool that allows scientists to easily utilizing their available computing resources for high throughput and comprehensive sequence analyses. The install package for W.ND-BLAST is freely downloadable from . With registration the software is free, installation, networking, and usage instructions are provided as well as a support forum. PMID:15819992

A maximally stable extremal region based scene text localization method

NASA Astrophysics Data System (ADS)

Xiao, Chengqiu; Ji, Lixin; Gao, Chao; Li, Shaomei

2015-07-01

Text localization in natural scene images is an important prerequisite for many content-based image analysis tasks. This paper proposes a novel text localization algorithm. Firstly, a fast pruning algorithm is designed to extract Maximally Stable Extremal Regions (MSER) as basic character candidates. Secondly, these candidates are filtered by using the properties of fitting ellipse and the distribution properties of characters to exclude most non-characters. Finally, a new extremal regions projection merging algorithm is designed to group character candidates into words. Experimental results show that the proposed method has an advantage in speed and achieve relatively high precision and recall rates than the latest published algorithms.

Efficient quantum repeater with respect to both entanglement-concentration rate and complexity of local operations and classical communication

NASA Astrophysics Data System (ADS)

Su, Zhaofeng; Guan, Ji; Li, Lvzhou

2018-01-01

Quantum entanglement is an indispensable resource for many significant quantum information processing tasks. However, in practice, it is difficult to distribute quantum entanglement over a long distance, due to the absorption and noise in quantum channels. A solution to this challenge is a quantum repeater, which can extend the distance of entanglement distribution. In this scheme, the time consumption of classical communication and local operations takes an important place with respect to time efficiency. Motivated by this observation, we consider a basic quantum repeater scheme that focuses on not only the optimal rate of entanglement concentration but also the complexity of local operations and classical communication. First, we consider the case where two different two-qubit pure states are initially distributed in the scenario. We construct a protocol with the optimal entanglement-concentration rate and less consumption of local operations and classical communication. We also find a criterion for the projective measurements to achieve the optimal probability of creating a maximally entangled state between the two ends. Second, we consider the case in which two general pure states are prepared and general measurements are allowed. We get an upper bound on the probability for a successful measurement operation to produce a maximally entangled state without any further local operations.

A model of individualized canonical microcircuits supporting cognitive operations

PubMed Central

Peterson, Andre D. H.; Haueisen, Jens; Knösche, Thomas R.

2017-01-01

Major cognitive functions such as language, memory, and decision-making are thought to rely on distributed networks of a large number of basic elements, called canonical microcircuits. In this theoretical study we propose a novel canonical microcircuit model and find that it supports two basic computational operations: a gating mechanism and working memory. By means of bifurcation analysis we systematically investigate the dynamical behavior of the canonical microcircuit with respect to parameters that govern the local network balance, that is, the relationship between excitation and inhibition, and key intrinsic feedback architectures of canonical microcircuits. We relate the local behavior of the canonical microcircuit to cognitive processing and demonstrate how a network of interacting canonical microcircuits enables the establishment of spatiotemporal sequences in the context of syntax parsing during sentence comprehension. This study provides a framework for using individualized canonical microcircuits for the construction of biologically realistic networks supporting cognitive operations. PMID:29200435

Diffusion and Localization of Relative Strategy Scores in The Minority Game

NASA Astrophysics Data System (ADS)

Granath, Mats; Perez-Diaz, Alvaro

2016-10-01

We study the equilibrium distribution of relative strategy scores of agents in the asymmetric phase (α ≡ P/N≳ 1) of the basic Minority Game using sign-payoff, with N agents holding two strategies over P histories. We formulate a statistical model that makes use of the gauge freedom with respect to the ordering of an agent's strategies to quantify the correlation between the attendance and the distribution of strategies. The relative score xin Z of the two strategies of an agent is described in terms of a one dimensional random walk with asymmetric jump probabilities, leading either to a static and asymmetric exponential distribution centered at x=0 for fickle agents or to diffusion with a positive or negative drift for frozen agents. In terms of scaled coordinates x/√{N} and t / N the distributions are uniquely given by α and in quantitative agreement with direct simulations of the game. As the model avoids the reformulation in terms of a constrained minimization problem it can be used for arbitrary payoff functions with little calculational effort and provides a transparent and simple formulation of the dynamics of the basic Minority Game in the asymmetric phase.

Localization of basic fibroblast growth factor binding sites in the chick embryonic neural retina.

PubMed

Cirillo, A; Arruti, C; Courtois, Y; Jeanny, J C

1990-12-01

We have investigated the localization of basic fibroblast growth factor (bFGF) binding sites during the development of the neural retina in the chick embryo. The specificity of the affinity of bFGF for its receptors was assessed by competition experiments with unlabelled growth factor or with heparin, as well as by heparitinase treatment of the samples. Two different types of binding sites were observed in the neural retina by light-microscopic autoradiography. The first type, localized mainly to basement membranes, was highly sensitive to heparitinase digestion and to competition with heparin. It was not developmentally regulated. The second type of binding site, resistant to heparin competition, appeared to be associated with retinal cells from the earliest stages studied (3-day-old embryo, stages 21-22 of Hamburger and Hamilton). Its distribution was found to vary during embryonic development, paralleling layering of the neural retina. Binding of bFGF to the latter sites was observed throughout the retinal neuroepithelium at early stages but displayed a distinct pattern at the time when the inner and outer plexiform layers were formed. During the development of the inner plexiform layer, a banded pattern of bFGF binding was observed. These bands, lying parallel to the vitreal surface, seemed to codistribute with the synaptic bands existing in the inner plexiform layer. The presence of intra-retinal bFGF binding sites whose distribution varies with embryonic development suggests a regulatory mechanism involving differential actions of bFGF on neural retinal cells.

Numerical Study of Nonlinear Structures of Locally Excited Marangoni Convection in the Long-Wave Approximation

NASA Astrophysics Data System (ADS)

Wertgeim, Igor I.

2018-02-01

We investigate stationary and non-stationary solutions of nonlinear equations of the long-wave approximation for the Marangoni convection caused by a localized source of heat or a surface active impurity (surfactant) in a thin horizontal layer of a viscous incompressible fluid with a free surface. The distribution of heat or concentration flux is determined by the uniform vertical gradient of temperature or impurity concentration, distorted by the imposition of a slightly inhomogeneous heating or of surfactant, localized in the horizontal plane. The lower boundary of the layer is considered thermally insulated or impermeable, whereas the upper boundary is free and deformable. The equations obtained in the long-wave approximation are formulated in terms of the amplitudes of the temperature distribution or impurity concentration, deformation of the surface, and vorticity. For a simplification of the problem, a sequence of nonlinear equations is obtained, which in the simplest form leads to a nonlinear Schrödinger equation with a localized potential. The basic state of the system, its dependence on the parameters and stability are investigated. For stationary solutions localized in the region of the surface tension inhomogeneity, domains of parameters corresponding to different spatial patterns are delineated.

Random bursts determine dynamics of active filaments.

PubMed

Weber, Christoph A; Suzuki, Ryo; Schaller, Volker; Aranson, Igor S; Bausch, Andreas R; Frey, Erwin

2015-08-25

Constituents of living or synthetic active matter have access to a local energy supply that serves to keep the system out of thermal equilibrium. The statistical properties of such fluctuating active systems differ from those of their equilibrium counterparts. Using the actin filament gliding assay as a model, we studied how nonthermal distributions emerge in active matter. We found that the basic mechanism involves the interplay between local and random injection of energy, acting as an analog of a thermal heat bath, and nonequilibrium energy dissipation processes associated with sudden jump-like changes in the system's dynamic variables. We show here how such a mechanism leads to a nonthermal distribution of filament curvatures with a non-Gaussian shape. The experimental curvature statistics and filament relaxation dynamics are reproduced quantitatively by stochastic computer simulations and a simple kinetic model.

Random bursts determine dynamics of active filaments

PubMed Central

Weber, Christoph A.; Suzuki, Ryo; Schaller, Volker; Aranson, Igor S.; Bausch, Andreas R.; Frey, Erwin

2015-01-01

Constituents of living or synthetic active matter have access to a local energy supply that serves to keep the system out of thermal equilibrium. The statistical properties of such fluctuating active systems differ from those of their equilibrium counterparts. Using the actin filament gliding assay as a model, we studied how nonthermal distributions emerge in active matter. We found that the basic mechanism involves the interplay between local and random injection of energy, acting as an analog of a thermal heat bath, and nonequilibrium energy dissipation processes associated with sudden jump-like changes in the system’s dynamic variables. We show here how such a mechanism leads to a nonthermal distribution of filament curvatures with a non-Gaussian shape. The experimental curvature statistics and filament relaxation dynamics are reproduced quantitatively by stochastic computer simulations and a simple kinetic model. PMID:26261319

The Gain of Resource Delegation in Distributed Computing Environments

NASA Astrophysics Data System (ADS)

Fölling, Alexander; Grimme, Christian; Lepping, Joachim; Papaspyrou, Alexander

In this paper, we address job scheduling in Distributed Computing Infrastructures, that is a loosely coupled network of autonomous acting High Performance Computing systems. In contrast to the common approach of mutual workload exchange, we consider the more intuitive operator's viewpoint of load-dependent resource reconfiguration. In case of a site's over-utilization, the scheduling system is able to lease resources from other sites to keep up service quality for its local user community. Contrary, the granting of idle resources can increase utilization in times of low local workload and thus ensure higher efficiency. The evaluation considers real workload data and is done with respect to common service quality indicators. For two simple resource exchange policies and three basic setups we show the possible gain of this approach and analyze the dynamics in workload-adaptive reconfiguration behavior.

Low reflection and field localization over surface plasmon device with subwavelength patterned aluminum film

NASA Astrophysics Data System (ADS)

Yuan, Ying; Peng, Sha; Long, Huabao; Liu, Runhan; Wei, Dong; Zhang, Xinyu; Wang, Haiwei; Xie, Changsheng

2018-02-01

In this paper, we propose a new device composed of patterned sub-wavelength arrays to investigate surface plasmons (SPs) over sub-wavelength metal nano-structures. The device consists of silicon substrate and sub-wavelength patterns fabricated on a layer of aluminum film with nanometer thickness. Each sub-wavelength pattern formed in aluminum film is composed of a basic nano-square and twelve triangles for shaping single nano-pattern, which are uniformly distributed on the four sides of each square. Reflectance spectra and electric field distribution in infrared region are simulated. Numerical simulation results demonstrate that the device can efficiently lower its reflectance in infrared spectrum, and the response frequency can be controlled by only changing the device parameters such as square side length and then triangle vertex angle. Besides, the simulated electric field distribution of the device shows obviously field localization effect at the edges of aluminum film nano-structure. The electric filed around the tips of aluminum triangles is localized into sub-wavelength scale, so as to be beyond the common diffraction limitation. Our work will help to reveal the interesting properties of SPs device, and also bring new prospect of photonic device.

Data for the synthesis of resorcinol-formaldehyde aerogels in acidic and basic media.

PubMed

Molina-Campos, Daniel F; Fonseca-Correa, Rafael A; Vargas-Delgadillo, Diana P; Giraldo, Liliana; Moreno-Piraján, Juan Carlos

2017-06-01

The aim of this research is to synthesise carbon aerogels and to compare the differences in their textural, morphological and chemical properties when synthesised in basic and acidic media, and with two different types of pretreatment carbonization and activation with CO 2 . Four samples are prepared and characterised using TGA-DTA, SEM, DRX, isotherm determination of N 2 adsorption-desorption at -196 °C and immersion calorimetry. The data for pore distribution are reported using non-local density functional theory and quenched solid density functional theory. Finally, with the immersion calorimetry data, the consistency between the results using this technique and those obtained using the nitrogen isotherms is analysed.

Microdose analysis of ion strikes on SRAM cells

NASA Astrophysics Data System (ADS)

Scheick, L.

2003-12-01

A method of measuring the effect from exposure to highly localized ionizing radiation on microstructures is described. The voltage at which a commercial SRAM cell cannot hold a programmed state changes with microdose. The microdose distribution across the array, in addition to the analysis of the occurrence of anomalous shifts in operating bias due to rare, large energy-deposition events is studied. The effect of multiple hits on a SRAM cell is presented. A general theory on multiple hits from which basic device parameters can be extracted is presented. SPICE, as well as analysis of basic device physics, is used to analyze the damage to individual transistors and the response of a SRAM cell.

Dispersal leads to spatial autocorrelation in species distributions: A simulation model

USGS Publications Warehouse

Bahn, V.; Krohn, W.B.; O'Connor, R.J.

2008-01-01

Compared to population growth regulated by local conditions, dispersal has been underappreciated as a central process shaping the spatial distribution of populations. This paper asks: (a) which conditions increase the importance of dispersers relative to local recruits in determining population sizes? and (b) how does dispersal influence the spatial distribution patterns of abundances among connected populations? We approached these questions with a simulation model of populations on a coupled lattice with cells of continuously varying habitat quality expressed as carrying capacities. Each cell contained a population with the basic dynamics of density-regulated growth, and was connected to other populations by immigration and emigration. The degree to which dispersal influenced the distribution of population sizes depended most strongly on the absolute amount of dispersal, and then on the potential population growth rate. Dispersal decaying in intensity with distance left close neighbours more alike in population size than distant populations, leading to an increase in spatial autocorrelation. The spatial distribution of species with low potential growth rates is more dependent on dispersal than that of species with high growth rates; therefore, distribution modelling for species with low growth rates requires particular attention to autocorrelation, and conservation management of these species requires attention to factors curtailing dispersal, such as fragmentation and dispersal barriers. ?? 2007 Elsevier B.V. All rights reserved.

Bag-of-features approach for improvement of lung tissue classification in diffuse lung disease

NASA Astrophysics Data System (ADS)

Kato, Noriji; Fukui, Motofumi; Isozaki, Takashi

2009-02-01

Many automated techniques have been proposed to classify diffuse lung disease patterns. Most of the techniques utilize texture analysis approaches with second and higher order statistics, and show successful classification result among various lung tissue patterns. However, the approaches do not work well for the patterns with inhomogeneous texture distribution within a region of interest (ROI), such as reticular and honeycombing patterns, because the statistics can only capture averaged feature over the ROI. In this work, we have introduced the bag-of-features approach to overcome this difficulty. In the approach, texture images are represented as histograms or distributions of a few basic primitives, which are obtained by clustering local image features. The intensity descriptor and the Scale Invariant Feature Transformation (SIFT) descriptor are utilized to extract the local features, which have significant discriminatory power due to their specificity to a particular image class. In contrast, the drawback of the local features is lack of invariance under translation and rotation. We improved the invariance by sampling many local regions so that the distribution of the local features is unchanged. We evaluated the performance of our system in the classification task with 5 image classes (ground glass, reticular, honeycombing, emphysema, and normal) using 1109 ROIs from 211 patients. Our system achieved high classification accuracy of 92.8%, which is superior to that of the conventional system with the gray level co-occurrence matrix (GLCM) feature especially for inhomogeneous texture patterns.

Anderson localization in metamaterials with compositional disorder

NASA Astrophysics Data System (ADS)

Torres-Herrera, E. J.; Izrailev, F. M.; Makarov, N. M.

2011-11-01

We consider one-dimensional periodic-on-average bi-layered models with random perturbations in dielectric constants of both basic slabs composing the structure unit-cell. We show that when the thicknesses da and db of basic layers are essentially nonequal, da ≠ db, the localization length Lloc is described by the universal expression for two cases: (a) both layers are made from right-handed materials (the RH-RH model), (b) the a layers are of a right-handed material while the b layers are of a left-handed material (the RH-LH model). For these models the derived expression for Lloc includes all possible correlations between two disorders. However, when da = db the RH-LH model exhibits a highly nontrivial properties originated from inhomogeneous distribution of the phase of propagating wave, even in the case of white-noise disorder. We analytically show that in this case the localization length diverges in the conventional second order in perturbation parameters. Therefore, recently numerically discovered anomalies in Lloc are due to the next order of approximation. On the other hand, for the RH-RH model the general expression for Lloc remains valid for da = db as well.

Astrobiology Extends Biology into Deep Time and Space

NASA Technical Reports Server (NTRS)

Desmarais, David

2003-01-01

To understand our own origins and to search for biospheres beyond Earth, we need a more robust concept of life itself. We must learn how to discriminate between attributes that are fundamental to all living systems versus those that represent principally local outcomes of long-term survival on Earth. We should identify the most basic environmental needs of life, chart the distribution of other habitable worlds, and understand the factors that created their distribution. Studies of microbial communities and the geologic record will be summarized that offer clues about the early evolution of our own biosphere as well as the signatures of life that we might find in the heavens.

A general framework for predicting delayed responses of ecological communities to habitat loss.

PubMed

Chen, Youhua; Shen, Tsung-Jen

2017-04-20

Although biodiversity crisis at different spatial scales has been well recognised, the phenomena of extinction debt and immigration credit at a crossing-scale context are, at best, unclear. Based on two community patterns, regional species abundance distribution (SAD) and spatial abundance distribution (SAAD), Kitzes and Harte (2015) presented a macroecological framework for predicting post-disturbance delayed extinction patterns in the entire ecological community. In this study, we further expand this basic framework to predict diverse time-lagged effects of habitat destruction on local communities. Specifically, our generalisation of KH's model could address the questions that could not be answered previously: (1) How many species are subjected to delayed extinction in a local community when habitat is destructed in other areas? (2) How do rare or endemic species contribute to extinction debt or immigration credit of the local community? (3) How will species differ between two local areas? From the demonstrations using two SAD models (single-parameter lognormal and logseries), the predicted patterns of the debt, credit, and change in the fraction of unique species can vary, but with consistencies and depending on several factors. The general framework deepens the understanding of the theoretical effects of habitat loss on community dynamic patterns in local samples.

The role of local interaction mechanics in fiber optic smart structures

NASA Astrophysics Data System (ADS)

Sirkis, J. S.; Dasgupta, A.

1993-04-01

The concept of using 'smart' composite materials/structures with built-in self-diagnostic capabilities for health monitoring involves embedding discrete and/or distributed sensory networks in the host composite material, along with a central and/or distributed artificial intelligence capability for signal processing, data collection, interpretation and diagnostic evaluations. This article concentrates on the sensory functions in 'smart' structure applications and concentrates in particular on optical fiber sensors. Specifically, we present an overview of recent research dealing with the basic mechanics of local interactions between the embedded optical fiber sensors and the surrounding host composite. The term 'local' is defined by length scales on the order of several optical fiber diameters. We examine some generic issues, such as the 'calibration' and 'obtrusivity' of the sensor, and the inherent damage caused by the sensor inclusions to the surrounding host and vice-versa under internal and/or external applied loads. Analytical, numerical and experimental results are presented regarding the influence of local strain concentrations caused by the sensory inclusions on sensor and host performance. The important issues examined are the local mechanistic effects of optical fiber coatings on the behavior of the sensor and the host, and mechanical survivability of optical fibers experiencing quasi-static and time-varying thermomechanical loading.

Results and Error Estimates from GRACE Forward Modeling over Greenland, Canada, and Alaska

NASA Astrophysics Data System (ADS)

Bonin, J. A.; Chambers, D. P.

2012-12-01

Forward modeling using a weighted least squares technique allows GRACE information to be projected onto a pre-determined collection of local basins. This decreases the impact of spatial leakage, allowing estimates of mass change to be better localized. The technique is especially valuable where models of current-day mass change are poor, such as over Greenland and Antarctica. However, the accuracy of the forward model technique has not been determined, nor is it known how the distribution of the local basins affects the results. We use a "truth" model composed of hydrology and ice-melt slopes as an example case, to estimate the uncertainties of this forward modeling method and expose those design parameters which may result in an incorrect high-resolution mass distribution. We then apply these optimal parameters in a forward model estimate created from RL05 GRACE data. We compare the resulting mass slopes with the expected systematic errors from the simulation, as well as GIA and basic trend-fitting uncertainties. We also consider whether specific regions (such as Ellesmere Island and Baffin Island) can be estimated reliably using our optimal basin layout.

Nucleolar Trafficking of Nucleostemin Family Proteins: Common versus Protein-Specific Mechanisms▿ §

PubMed Central

Meng, Lingjun; Zhu, Qubo; Tsai, Robert Y. L.

2007-01-01

The nucleolus has begun to emerge as a subnuclear organelle capable of modulating the activities of nuclear proteins in a dynamic and cell type-dependent manner. It remains unclear whether one can extrapolate a rule that predicts the nucleolar localization of multiple proteins based on protein sequence. Here, we address this issue by determining the shared and unique mechanisms that regulate the static and dynamic distributions of a family of nucleolar GTP-binding proteins, consisting of nucleostemin (NS), guanine nucleotide binding protein-like 3 (GNL3L), and Ngp1. The nucleolar residence of GNL3L is short and primarily controlled by its basic-coiled-coil domain, whereas the nucleolar residence of NS and Ngp1 is long and requires the basic and the GTP-binding domains, the latter of which functions as a retention signal. All three proteins contain a nucleoplasmic localization signal (NpLS) that prevents their nucleolar accumulation. Unlike that of the basic domain, the activity of NpLS is dynamically controlled by the GTP-binding domain. The nucleolar retention and the NpLS-regulating functions of the G domain involve specific residues that cannot be predicted by overall protein homology. This work reveals common and protein-specific mechanisms underlying the nucleolar movement of NS family proteins. PMID:17923687

Nonlinear development and secondary instability of Gortler vortices in hypersonic flows

NASA Technical Reports Server (NTRS)

Fu, Yibin B.; Hall, Philip

1991-01-01

In a hypersonic boundary layer over a wall of variable curvature, the region most susceptible to Goertler vortices is the temperature adjustment layer over which the basic state temperature decreases monotonically to its free stream value. Except for a special wall curvature distribution, the evolution of Goertler vortices trapped in the temperature adjustment layer will in general be strongly affected by the boundary layer growth through the O(M sup 3/2) curvature of the basic state, where M is the free stream Mach number. Only when the local wavenumber becomes as large as of order M sup 3/8, do nonparallel effects become negligible in the determination of stability properties. In the latter case, Goertler vortices will be trapped in a thin layer of O(epsilon sup 1/2) thickness which is embedded in the temperature adjustment layer; here epsilon is the inverse of the local wavenumber. A weakly nonlinear theory is presented in which the initial nonlinear development of Goertler vortices in the neighborhood of the neutral position is studied and two coupled evolution equations are derived. From these, it can be determined whether the vortices are decaying or growing depending on the sign of a constant which is related to wall curvature and the basic state temperature.

PET Imaging: Basics and New Trends

NASA Astrophysics Data System (ADS)

Dahlbom, Magnus

Positron Emission Tomography or PET is a noninvasive molecular imaging method used both in research to study biology and disease, and clinically as a routine diagnostic imaging tool. In PET imaging, the subject is injected with a tracer labeled with a positron-emitting isotope and is then placed in a scanner to localize the radioactive tracer in the body. The localization of the tracer utilizes the unique decay characteristics of isotopes decaying by positron emission. In the PET scanner, a large number of scintillation detectors use coincidence detection of the annihilation radiation that is emitted as a result of the positron decay. By collecting a large number of these coincidence events, together with tomographic image reconstruction methods, the 3-D distribution of the radioactive tracer in the body can be reconstructed. Depending on the type of tracer used, the distribution will reflect a particular biological process, such as glucose metabolism when fluoro-deoxyglucose is used. PET has evolved from a relatively inefficient single-slice imaging system with relatively poor spatial resolution to an efficient, high-resolution imaging modality which can acquire a whole-body scan in a few minutes. This chapter will describe the basic physics and instrumentation used in PET. The various corrections that are necessary to apply to the acquired data in order to produce quantitative images are also described. Finally, some of the latest trends in instrumentation development are also discussed.

Understanding natural systems; a perspective for land-use planning in Appalachian Kentucky

USGS Publications Warehouse

Newell, Wayne L.

1978-01-01

An eight-county area at the headwaters of the Kentucky River has been designated the Kentucky River Area Development District (KRADD) by the Appalachian Regional Commission. The objective of the project described in this report has been to provide materials to KRADD planners in a format and containing terminology usable by local people untrained in earth science. Experimental maps (not included in this report) have been prepared largely from preexisting data. Time and cost limitations required a regional analysis as well as somewhat more detailed examples of selected localities. Most of the maps produced to meet these needs show the abundance and distribution of naturally occurring materials and the areas affected by various geomorphic processes. Three types of maps, showing current land use, slope, and flood-prone areas, present both basic and derived data directly applicable to specific land-use decisions. Basic map information on quality and quantity of surface and ground water, bedrock and surficial geology, and mineral fuels can be interpreted for a wide variety of current and potential uses. Texts accompanying the maps explain bedrock control of geomorphic processes, distribution and significance of surficial deposits, and hydrologic characteristics of the intricately dissected eastern Kentucky terrain. Within this conceptual framework, geomorphic processes and the landscape may be evaluated in humanly significant terms of low to high potential risk, thereby indicating both opportunities and limitations for land use.

Impact of Hearing Aid Technology on Outcomes in Daily Life III: Localization.

PubMed

Johnson, Jani A; Xu, Jingjing; Cox, Robyn M

Compared to basic-feature hearing aids, premium-feature hearing aids have more advanced technologies and sophisticated features. The objective of this study was to explore the difference between premium-feature and basic-feature hearing aids in horizontal sound localization in both laboratory and daily life environments. We hypothesized that premium-feature hearing aids would yield better localization performance than basic-feature hearing aids. Exemplars of premium-feature and basic-feature hearing aids from two major manufacturers were evaluated. Forty-five older adults (mean age 70.3 years) with essentially symmetrical mild to moderate sensorineural hearing loss were bilaterally fitted with each of the four pairs of hearing aids. Each pair of hearing aids was worn during a 4-week field trial and then evaluated using laboratory localization tests and a standardized questionnaire. Laboratory localization tests were conducted in a sound-treated room with a 360°, 24-loudspeaker array. Test stimuli were high frequency and low frequency filtered short sentences. The localization test in quiet was designed to assess the accuracy of front/back localization, while the localization test in noise was designed to assess the accuracy of locating sound sources throughout a 360° azimuth in the horizontal plane. Laboratory data showed that unaided localization was not significantly different from aided localization when all hearing aids were combined. Questionnaire data showed that aided localization was significantly better than unaided localization in everyday situations. Regarding the difference between premium-feature and basic-feature hearing aids, laboratory data showed that, overall, the premium-feature hearing aids yielded more accurate localization than the basic-feature hearing aids when high-frequency stimuli were used, and the listening environment was quiet. Otherwise, the premium-feature and basic-feature hearing aids yielded essentially the same performance in other laboratory tests and in daily life. The findings were consistent for both manufacturers. Laboratory tests for two of six major manufacturers showed that premium-feature hearing aids yielded better localization performance than basic-feature hearing aids in one out of four laboratory conditions. There was no difference between the two feature levels in self-reported everyday localization. Effectiveness research with different hearing aid technologies is necessary, and more research with other manufacturers' products is needed. Furthermore, these results confirm previous observations that research findings in laboratory conditions might not translate to everyday life.

47 CFR 36.212 - Basic local services revenue-Account 5000 (Class B telephone companies); Basic area revenue...

Code of Federal Regulations, 2010 CFR

2010-10-01

... (Class B telephone companies); Basic area revenue-Account 5001 (Class A telephone companies). 36.212..., REVENUES, EXPENSES, TAXES AND RESERVES FOR TELECOMMUNICATIONS COMPANIES 1 Operating Revenues and Certain... companies); Basic area revenue—Account 5001 (Class A telephone companies). (a) Local private line revenues...

UGV Control Interoperability Profile (IOP), Version 0

DTIC Science & Technology

2011-12-21

task or function associated with the ID (e.g. “select asset gear” and “switch between local and zulu time display”). Category Provides a high...CTRL- Basic Status-2 view Zulu date and time in Date-Time-Group (DTG) format Basic Status S SWP Icon (text) CTRL- Basic Status-3 switch...between local and zulu time display Basic Status C SW1 CTRL- Basic Status-4 view unique identifier/call sign for each asset Basic Status S

Extreme deconvolution: Inferring complete distribution functions from noisy, heterogeneous and incomplete observations

NASA Astrophysics Data System (ADS)

Bovy Jo; Hogg, David W.; Roweis, Sam T.

2011-06-01

We generalize the well-known mixtures of Gaussians approach to density estimation and the accompanying Expectation-Maximization technique for finding the maximum likelihood parameters of the mixture to the case where each data point carries an individual d-dimensional uncertainty covariance and has unique missing data properties. This algorithm reconstructs the error-deconvolved or "underlying" distribution function common to all samples, even when the individual data points are samples from different distributions, obtained by convolving the underlying distribution with the heteroskedastic uncertainty distribution of the data point and projecting out the missing data directions. We show how this basic algorithm can be extended with conjugate priors on all of the model parameters and a "split-and-"erge- procedure designed to avoid local maxima of the likelihood. We demonstrate the full method by applying it to the problem of inferring the three-dimensional veloc! ity distribution of stars near the Sun from noisy two-dimensional, transverse velocity measurements from the Hipparcos satellite.

Improved Quantum Artificial Fish Algorithm Application to Distributed Network Considering Distributed Generation.

PubMed

Du, Tingsong; Hu, Yang; Ke, Xianting

2015-01-01

An improved quantum artificial fish swarm algorithm (IQAFSA) for solving distributed network programming considering distributed generation is proposed in this work. The IQAFSA based on quantum computing which has exponential acceleration for heuristic algorithm uses quantum bits to code artificial fish and quantum revolving gate, preying behavior, and following behavior and variation of quantum artificial fish to update the artificial fish for searching for optimal value. Then, we apply the proposed new algorithm, the quantum artificial fish swarm algorithm (QAFSA), the basic artificial fish swarm algorithm (BAFSA), and the global edition artificial fish swarm algorithm (GAFSA) to the simulation experiments for some typical test functions, respectively. The simulation results demonstrate that the proposed algorithm can escape from the local extremum effectively and has higher convergence speed and better accuracy. Finally, applying IQAFSA to distributed network problems and the simulation results for 33-bus radial distribution network system show that IQAFSA can get the minimum power loss after comparing with BAFSA, GAFSA, and QAFSA.

Improved Quantum Artificial Fish Algorithm Application to Distributed Network Considering Distributed Generation

PubMed Central

Hu, Yang; Ke, Xianting

2015-01-01

An improved quantum artificial fish swarm algorithm (IQAFSA) for solving distributed network programming considering distributed generation is proposed in this work. The IQAFSA based on quantum computing which has exponential acceleration for heuristic algorithm uses quantum bits to code artificial fish and quantum revolving gate, preying behavior, and following behavior and variation of quantum artificial fish to update the artificial fish for searching for optimal value. Then, we apply the proposed new algorithm, the quantum artificial fish swarm algorithm (QAFSA), the basic artificial fish swarm algorithm (BAFSA), and the global edition artificial fish swarm algorithm (GAFSA) to the simulation experiments for some typical test functions, respectively. The simulation results demonstrate that the proposed algorithm can escape from the local extremum effectively and has higher convergence speed and better accuracy. Finally, applying IQAFSA to distributed network problems and the simulation results for 33-bus radial distribution network system show that IQAFSA can get the minimum power loss after comparing with BAFSA, GAFSA, and QAFSA. PMID:26447713

Effect of platykurtic and leptokurtic distributions in the random-field Ising model: mean-field approach.

PubMed

Duarte Queirós, Sílvio M; Crokidakis, Nuno; Soares-Pinto, Diogo O

2009-07-01

The influence of the tail features of the local magnetic field probability density function (PDF) on the ferromagnetic Ising model is studied in the limit of infinite range interactions. Specifically, we assign a quenched random field whose value is in accordance with a generic distribution that bears platykurtic and leptokurtic distributions depending on a single parameter tau<3 to each site. For tau<5/3, such distributions, which are basically Student-t and r distribution extended for all plausible real degrees of freedom, present a finite standard deviation, if not the distribution has got the same asymptotic power-law behavior as a alpha-stable Lévy distribution with alpha=(3-tau)/(tau-1). For every value of tau, at specific temperature and width of the distribution, the system undergoes a continuous phase transition. Strikingly, we impart the emergence of an inflexion point in the temperature-PDF width phase diagrams for distributions broader than the Cauchy-Lorentz (tau=2) which is accompanied with a divergent free energy per spin (at zero temperature).

Species richness, distribution and genetic diversity of Caenorhabditis nematodes in a remote tropical rainforest

PubMed Central

2013-01-01

Background In stark contrast to the wealth of detail about C. elegans developmental biology and molecular genetics, biologists lack basic data for understanding the abundance and distribution of Caenorhabditis species in natural areas that are unperturbed by human influence. Methods Here we report the analysis of dense sampling from a small, remote site in the Amazonian rain forest of the Nouragues Natural Reserve in French Guiana. Results Sampling of rotting fruits and flowers revealed proliferating populations of Caenorhabditis, with up to three different species co-occurring within a single substrate sample, indicating remarkable overlap of local microhabitats. We isolated six species, representing the highest local species richness for Caenorhabditis encountered to date, including both tropically cosmopolitan and geographically restricted species not previously isolated elsewhere. We also documented the structure of within-species molecular diversity at multiple spatial scales, focusing on 57 C. briggsae isolates from French Guiana. Two distinct genetic subgroups co-occur even within a single fruit. However, the structure of C. briggsae population genetic diversity in French Guiana does not result from strong local patterning but instead presents a microcosm of global patterns of differentiation. We further integrate our observations with new data from nearly 50 additional recently collected C. briggsae isolates from both tropical and temperate regions of the world to re-evaluate local and global patterns of intraspecific diversity, providing the most comprehensive analysis to date for C. briggsae population structure across multiple spatial scales. Conclusions The abundance and species richness of Caenorhabditis nematodes is high in a Neotropical rainforest habitat that is subject to minimal human interference. Microhabitat preferences overlap for different local species, although global distributions include both cosmopolitan and geographically restricted groups. Local samples for the cosmopolitan C. briggsae mirror its pan-tropical patterns of intraspecific polymorphism. It remains an important challenge to decipher what drives Caenorhabditis distributions and diversity within and between species. PMID:23311925

Water resources data for New Mexico, water year 1966; Part 1. Surface water records

USGS Publications Warehouse

,

1967-01-01

by the Geological Survey in annual reports on a State-boundary basis. Distribution of these basic-data reports is limited and primarily for local needs. The records will be published in Geological Survey water-supply papers at 5-year intervals. These 5-year water-supply papers will show daily discharge and will be compiled on the same geographical areas previously used for the annual series; however, some of the 14 parts of conterminous United States will be further subdivided.

47 CFR 32.5000 - Basic local service revenue.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 2 2011-10-01 2011-10-01 false Basic local service revenue. 32.5000 Section 32.5000 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES UNIFORM SYSTEM OF ACCOUNTS FOR TELECOMMUNICATIONS COMPANIES Instructions For Revenue Accounts § 32.5000 Basic...

47 CFR 32.5000 - Basic local service revenue.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 2 2014-10-01 2014-10-01 false Basic local service revenue. 32.5000 Section 32.5000 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES UNIFORM SYSTEM OF ACCOUNTS FOR TELECOMMUNICATIONS COMPANIES Instructions For Revenue Accounts § 32.5000 Basic...

47 CFR 32.5000 - Basic local service revenue.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 2 2013-10-01 2013-10-01 false Basic local service revenue. 32.5000 Section 32.5000 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES UNIFORM SYSTEM OF ACCOUNTS FOR TELECOMMUNICATIONS COMPANIES Instructions For Revenue Accounts § 32.5000 Basic...

Distributing File-Based Data to Remote Sites Within the BABAR Collaboration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gowdy, Stephen J.

BABAR [1] uses two formats for its data: Objectivity database and root [2] files. This poster concerns the distribution of the latter--for Objectivity data see [3]. The BABAR analysis data is stored in root files--one per physics run and analysis selection channel--maintained in a large directory tree. Currently BABAR has more than 4.5 TBytes in 200,000 root files. This data is (mostly) produced at SLAC, but is required for analysis at universities and research centers throughout the us and Europe. Two basic problems confront us when we seek to import bulk data from slac to an institute's local storage viamore » the network. We must determine which files must be imported (depending on the local site requirements and which files have already been imported), and we must make the optimum use of the network when transferring the data. Basic ftp-like tools (ftp, scp, etc) do not attempt to solve the first problem. More sophisticated tools like rsync [4], the widely-used mirror/synchronization program, compare local and remote file systems, checking for changes (based on file date, size and, if desired, an elaborate checksum) in order to only copy new or modified files. However rsync allows for only limited file selection. Also when, as in BABAR, an extremely large directory structure must be scanned, rsync can take several hours just to determine which files need to be copied. Although rsync (and scp) provides on-the-fly compression, it does not allow us to optimize the network transfer by using multiple streams, adjusting the tcp window size, or separating encrypted authentication from unencrypted data channels.« less

Finite-analytic numerical solution of heat transfer in two-dimensional cavity flow

NASA Technical Reports Server (NTRS)

Chen, C.-J.; Naseri-Neshat, H.; Ho, K.-S.

1981-01-01

Heat transfer in cavity flow is numerically analyzed by a new numerical method called the finite-analytic method. The basic idea of the finite-analytic method is the incorporation of local analytic solutions in the numerical solutions of linear or nonlinear partial differential equations. In the present investigation, the local analytic solutions for temperature, stream function, and vorticity distributions are derived. When the local analytic solution is evaluated at a given nodal point, it gives an algebraic relationship between a nodal value in a subregion and its neighboring nodal points. A system of algebraic equations is solved to provide the numerical solution of the problem. The finite-analytic method is used to solve heat transfer in the cavity flow at high Reynolds number (1000) for Prandtl numbers of 0.1, 1, and 10.

Using Film and Social Media for Successful Earth Science Outreach in Nepal and Indonesia

NASA Astrophysics Data System (ADS)

Kerlow, I.

2016-12-01

We are using social media effectively to bring a documentary film about earthquakes in Nepal to Nepalese audiences that live in tectonically hazardous areas, and a tsunami preparedness movie to the people of Banda Aceh. The one-week online preview of the Nepali-subtitled version of the movie received over 79,000 post Facebook Likes. The movie makes extensive use of animation techniques in addition to live action to explain basic facts about seismic activity in the Himalaya region and also basic preparedness concepts. This presentation reviews the social media campaign designed and implemented to bring preparedness movies to large local audiences, as well as the development, production, and world distribution of natural hazards documentary films with scientific depth but designed for a mainstream audience.

A review of second law techniques applicable to basic thermal science research

NASA Astrophysics Data System (ADS)

Drost, M. Kevin; Zamorski, Joseph R.

1988-11-01

This paper reports the results of a review of second law analysis techniques which can contribute to basic research in the thermal sciences. The review demonstrated that second law analysis has a role in basic thermal science research. Unlike traditional techniques, second law analysis accurately identifies the sources and location of thermodynamic losses. This allows the development of innovative solutions to thermal science problems by directing research to the key technical issues. Two classes of second law techniques were identified as being particularly useful. First, system and component investigations can provide information of the source and nature of irreversibilities on a macroscopic scale. This information will help to identify new research topics and will support the evaluation of current research efforts. Second, the differential approach can provide information on the causes and spatial and temporal distribution of local irreversibilities. This information enhances the understanding of fluid mechanics, thermodynamics, and heat and mass transfer, and may suggest innovative methods for reducing irreversibilities.

Fault identification and localization for Ethernet Passive Optical Network using L-band ASE source and various types of fiber Bragg grating

NASA Astrophysics Data System (ADS)

Naim, Nani Fadzlina; Bakar, A. Ashrif A.; Ab-Rahman, Mohammad Syuhaimi

2018-01-01

This paper presents a centralized and fault localization technique for Ethernet Passive Optical Access Network. This technique employs L-band Amplified Spontaneous Emission (ASE) as the monitoring source and various fiber Bragg Gratings (FBGs) as the fiber's identifier. An FBG with a unique combination of Bragg wavelength, reflectivity and bandwidth is inserted at each distribution fiber. The FBG reflection spectrum will be analyzed using an optical spectrum analyzer (OSA) to monitor the condition of the distribution fiber. Various FBGs reflection spectra is employed to optimize the limited bandwidth of monitoring source, thus allows more fibers to be monitored. Basically, one Bragg wavelength is shared by two distinct FBGs with different reflectivity and bandwidth. The experimental result shows that the system is capable to monitor up to 32 customers with OSNR value of ∼1.2 dB and monitoring power received of -24 dBm. This centralized and simple monitoring technique demonstrates a low power, cost efficient and low bandwidth requirement system.

The Principles of Buoyancy in Marine Fish Eggs and Their Vertical Distributions across the World Oceans.

PubMed

Sundby, Svein; Kristiansen, Trond

2015-01-01

Buoyancy acting on plankton, i.e. the difference in specific gravity between plankton and the ambient water, is a function of salinity and temperature. From specific gravity measurements of marine fish eggs salinity appears to be the only determinant of the buoyancy indicating that the thermal expansions of the fish egg and the ambient seawater are equal. We analyze the mechanisms behind thermal expansion in fish eggs in order to determine to what extent it can be justified to neglect the effects of temperature on buoyancy. Our results confirm the earlier assumptions that salinity is the basic determinant on buoyancy in marine fish eggs that, in turn, influence the vertical distributions and, consequently, the dispersal of fish eggs from the spawning areas. Fish populations have adapted accordingly by producing egg specific gravities that tune the egg buoyancy to create specific vertical distributions for each local population. A wide variety of buoyancy adaptations are found among fish populations. The ambient physical conditions at the spawning sites form a basic constraint for adaptation. In coastal regions where salinity increases with depth, and where the major fraction of the fish stocks spawns, pelagic and mesopelagic egg distributions dominate. However, in the larger part of worlds' oceans salinity decreases with depth resulting in different egg distributions. Here, the principles of vertical distributions of fish eggs in the world oceans are presented in an overarching framework presenting the basic differences between regions, mainly coastal, where salinity increases with depth and the major part of the world oceans where salinity decreases with depth. We show that under these latter conditions, steady-state vertical distribution of mesopelagic fish eggs cannot exist as it does in most coastal regions. In fact, a critical spawning depth must exist where spawning below this depth threshold results in eggs sinking out of the water column and become lost for recruitment to the population. An example of adaptation to such conditions is Cape hake spawning above the critical layer in the Northern Benguela upwelling ecosystem. The eggs rise slowly in the onshore subsurface current below the Ekman layer, hence being advected inshore where the hatched larvae concentrate with optimal feeding conditions.

Crossover Distribution and Frequency Are Regulated by him-5 in Caenorhabditis elegans

PubMed Central

Meneely, Philip M.; McGovern, Olivia L.; Heinis, Frazer I.; Yanowitz, Judith L.

2012-01-01

Mutations in the him-5 gene in Caenorhabditis elegans strongly reduce the frequency of crossovers on the X chromosome, with lesser effects on the autosomes. him-5 mutants also show a change in crossover distribution on both the X and autosomes. These phenotypes are accompanied by a delayed entry into pachytene and premature desynapsis of the X chromosome. The nondisjunction, progression defects and desynapsis can be rescued by an exogenous source of double strand breaks (DSBs), indicating that the role of HIM-5 is to promote the formation of meiotic DSBs. Molecular cloning of the gene shows that the inferred HIM-5 product is a highly basic protein of 252 amino acids with no clear orthologs in other species, including other Caenorhabditis species. Although him-5 mutants are defective in segregation of the X chromosome, HIM-5 protein localizes preferentially to the autosomes. The mutant phenotypes and localization of him-5 are similar but not identical to the results seen with xnd-1, although unlike xnd-1, him-5 has no apparent effect on the acetylation of histone H2A on lysine 5 (H2AacK5). The localization of HIM-5 to the autosomes depends on the activities of both xnd-1 and him-17 allowing us to begin to establish pathways for the control of crossover distribution and frequency. PMID:22267496

Crossover distribution and frequency are regulated by him-5 in Caenorhabditis elegans.

PubMed

Meneely, Philip M; McGovern, Olivia L; Heinis, Frazer I; Yanowitz, Judith L

2012-04-01

Mutations in the him-5 gene in Caenorhabditis elegans strongly reduce the frequency of crossovers on the X chromosome, with lesser effects on the autosomes. him-5 mutants also show a change in crossover distribution on both the X and autosomes. These phenotypes are accompanied by a delayed entry into pachytene and premature desynapsis of the X chromosome. The nondisjunction, progression defects and desynapsis can be rescued by an exogenous source of double strand breaks (DSBs), indicating that the role of HIM-5 is to promote the formation of meiotic DSBs. Molecular cloning of the gene shows that the inferred HIM-5 product is a highly basic protein of 252 amino acids with no clear orthologs in other species, including other Caenorhabditis species. Although him-5 mutants are defective in segregation of the X chromosome, HIM-5 protein localizes preferentially to the autosomes. The mutant phenotypes and localization of him-5 are similar but not identical to the results seen with xnd-1, although unlike xnd-1, him-5 has no apparent effect on the acetylation of histone H2A on lysine 5 (H2AacK5). The localization of HIM-5 to the autosomes depends on the activities of both xnd-1 and him-17 allowing us to begin to establish pathways for the control of crossover distribution and frequency.

MRI-Guided Focused Ultrasound as a New Method of Drug Delivery

PubMed Central

Thanou, M.; Gedroyc, W.

2013-01-01

Ultrasound-mediated drug delivery under the guidance of an imaging modality can improve drug disposition and achieve site-specific drug delivery. The term focal drug delivery has been introduced to describe the focal targeting of drugs in tissues with the help of imaging and focused ultrasound. Focal drug delivery aims to improve the therapeutic profile of drugs by improving their specificity and their permeation in defined areas. Focused-ultrasound- (FUS-) mediated drug delivery has been applied with various molecules to improve their local distribution in tissues. FUS is applied with the aid of microbubbles to enhance the permeability of bioactive molecules across BBB and improve drug distribution in the brain. Recently, FUS has been utilised in combination with MRI-labelled liposomes that respond to temperature increase. This strategy aims to “activate” nanoparticles to release their cargo locally when triggered by hyperthermia induced by FUS. MRI-guided FUS drug delivery provides the opportunity to improve drug bioavailability locally and therefore improve the therapeutic profiles of drugs. This drug delivery strategy can be directly translated to clinic as MRg FUS is a promising clinically therapeutic approach. However, more basic research is required to understand the physiological mechanism of FUS-enhanced drug delivery. PMID:23738076

Linking parasite populations in hosts to parasite populations in space through Taylor's law and the negative binomial distribution

PubMed Central

Poulin, Robert; Lagrue, Clément

2017-01-01

The spatial distribution of individuals of any species is a basic concern of ecology. The spatial distribution of parasites matters to control and conservation of parasites that affect human and nonhuman populations. This paper develops a quantitative theory to predict the spatial distribution of parasites based on the distribution of parasites in hosts and the spatial distribution of hosts. Four models are tested against observations of metazoan hosts and their parasites in littoral zones of four lakes in Otago, New Zealand. These models differ in two dichotomous assumptions, constituting a 2 × 2 theoretical design. One assumption specifies whether the variance function of the number of parasites per host individual is described by Taylor's law (TL) or the negative binomial distribution (NBD). The other assumption specifies whether the numbers of parasite individuals within each host in a square meter of habitat are independent or perfectly correlated among host individuals. We find empirically that the variance–mean relationship of the numbers of parasites per square meter is very well described by TL but is not well described by NBD. Two models that posit perfect correlation of the parasite loads of hosts in a square meter of habitat approximate observations much better than two models that posit independence of parasite loads of hosts in a square meter, regardless of whether the variance–mean relationship of parasites per host individual obeys TL or NBD. We infer that high local interhost correlations in parasite load strongly influence the spatial distribution of parasites. Local hotspots could influence control and conservation of parasites. PMID:27994156

Local Responses to Global Problems: A Key to Meeting Basic Human Needs. Worldwatch Paper 17.

ERIC Educational Resources Information Center

Stokes, Bruce

The booklet maintains that the key to meeting basic human needs is the participation of individuals and communities in local problem solving. Some of the most important achievements in providing food, upgrading housing, improving human health, and tapping new energy sources, comes through local self-help projects. Proponents of local efforts at…

Density-functional theory based on the electron distribution on the energy coordinate

NASA Astrophysics Data System (ADS)

Takahashi, Hideaki

2018-03-01

We developed an electronic density functional theory utilizing a novel electron distribution n(ɛ) as a basic variable to compute ground state energy of a system. n(ɛ) is obtained by projecting the electron density n({\\boldsymbol{r}}) defined on the space coordinate {\\boldsymbol{r}} onto the energy coordinate ɛ specified with the external potential {\\upsilon }ext}({\\boldsymbol{r}}) of interest. It was demonstrated that the Kohn-Sham equation can also be formulated with the exchange-correlation functional E xc[n(ɛ)] that employs the density n(ɛ) as an argument. It turned out an exchange functional proposed in our preliminary development suffices to describe properly the potential energies of several types of chemical bonds with comparable accuracies to the corresponding functional based on local density approximation. As a remarkable feature of the distribution n(ɛ) it inherently involves the spatially non-local information of the exchange hole at the bond dissociation limit in contrast to conventional approximate functionals. By taking advantage of this property we also developed a prototype of the static correlation functional E sc including no empirical parameters, which showed marked improvements in describing the dissociations of covalent bonds in {{{H}}}2,{{{C}}}2{{{H}}}4 and {CH}}4 molecules.

Music Basic Skills.

ERIC Educational Resources Information Center

Kentucky State Dept. of Education, Frankfort.

This document is a statement of the basic music skills that Kentucky students should develop. This skills list does not replace any locally developed curriculum. It is intended as a guide for local school districts in Kentucky in their development of a detailed K-12 curriculum. The skills presented are considered basic to a sound education program…

Processes affecting altitudinal distribution of invasive Ageratina adenophora in western Himalaya: The role of local adaptation and the importance of different life-cycle stages

PubMed Central

Kühn, Ingolf; Ahmad, Mustaqeem; Michalski, Stefan; Auge, Harald

2017-01-01

The spread of invasive plants along elevational gradients is considered a threat to fragile mountain ecosystems, but it can also provide the opportunity to better understand some of the basic processes driving the success of invasive species. Ageratina adenophora (Asteraceae) is an invasive plant of global importance and has a broad distribution along elevational gradients in the Western Himalayas. Our study aimed at understanding the role of evolutionary processes (e.g. local adaptation and clinal differentiation) and different life history stages in shaping the distribution pattern of the invasive plant along an elevational gradient in the Western Himalaya. We carried out extensive distributional surveys, established a reciprocal transplant experiment with common gardens at three elevational levels, and measured a suite of traits related to germination, growth, reproduction and phenology. Our results showed a lack of local adaptation, and we did not find any evidence for clinal differentiation in any measured trait except a rather weak signal for plant height. We found that seed germination was the crucial life-cycle transition in determining the lower range limit while winter mortality of plants shaped the upper range limit in our study area, thus explaining the hump shaped distribution pattern. Differences in trait values between gardens for most traits indicated a high degree of phenotypic plasticity. Possible causes such as apomixis, seed dispersal among sites, and pre-adaptation might have confounded evolutionary processes to act upon. Our results suggest that the success and spread of Ageratina adenophora are dependent on different life history stages at different elevations that are controlled by abiotic conditions. PMID:29125852

Processes affecting altitudinal distribution of invasive Ageratina adenophora in western Himalaya: The role of local adaptation and the importance of different life-cycle stages.

PubMed

Datta, Arunava; Kühn, Ingolf; Ahmad, Mustaqeem; Michalski, Stefan; Auge, Harald

2017-01-01

The spread of invasive plants along elevational gradients is considered a threat to fragile mountain ecosystems, but it can also provide the opportunity to better understand some of the basic processes driving the success of invasive species. Ageratina adenophora (Asteraceae) is an invasive plant of global importance and has a broad distribution along elevational gradients in the Western Himalayas. Our study aimed at understanding the role of evolutionary processes (e.g. local adaptation and clinal differentiation) and different life history stages in shaping the distribution pattern of the invasive plant along an elevational gradient in the Western Himalaya. We carried out extensive distributional surveys, established a reciprocal transplant experiment with common gardens at three elevational levels, and measured a suite of traits related to germination, growth, reproduction and phenology. Our results showed a lack of local adaptation, and we did not find any evidence for clinal differentiation in any measured trait except a rather weak signal for plant height. We found that seed germination was the crucial life-cycle transition in determining the lower range limit while winter mortality of plants shaped the upper range limit in our study area, thus explaining the hump shaped distribution pattern. Differences in trait values between gardens for most traits indicated a high degree of phenotypic plasticity. Possible causes such as apomixis, seed dispersal among sites, and pre-adaptation might have confounded evolutionary processes to act upon. Our results suggest that the success and spread of Ageratina adenophora are dependent on different life history stages at different elevations that are controlled by abiotic conditions.

Local tissue air ratio in an anatomic phantom for 60Co total body irradiation.

PubMed

Vrtar, M; Purisić, A

1991-07-01

Tissue-air ratio (TAR), as the basic dosimetric function, is not ideally applicable to all important locations in total body irradiation (TBI) dosimetry because it generally refers to central ray measurements. We therefore introduced the local TAR which depends on the specific distribution of the scattering centres around the location of interest. Local TAR measurements were performed in an anatomic water phantom, produced by a sculptor, representing a patient during TBI in the real treatment position. A comparison has been made between TAR values, defined on the beam's ray at different locations in the anatomic phantom and cubic phantoms of different size. The local TAR values in the anatomic phantom, having more realistic outer surface curvatures, are lower by a few percent in most locations. We consider these values more accurate and better applicable to TBI conditions than those obtained in cubic water phantoms, even if the volume of the phantom is adapted to the particular side of the body.

Reduction of Helicopter Blade-Vortex Interaction Noise by Active Rotor Control Technology

NASA Technical Reports Server (NTRS)

Yu, Yung H.; Gmelin, Bernd; Splettstoesser, Wolf; Brooks, Thomas F.; Philippe, Jean J.; Prieur, Jean

1997-01-01

Helicopter blade-vortex interaction noise is one of the most severe noise sources and is very important both in community annoyance and military detection. Research over the decades has substantially improved basic physical understanding of the mechanisms generating rotor blade-vortex interaction noise and also of controlling techniques, particularly using active rotor control technology. This paper reviews active rotor control techniques currently available for rotor blade vortex interaction noise reduction, including higher harmonic pitch control, individual blade control, and on-blade control technologies. Basic physical mechanisms of each active control technique are reviewed in terms of noise reduction mechanism and controlling aerodynamic or structural parameters of a blade. Active rotor control techniques using smart structures/materials are discussed, including distributed smart actuators to induce local torsional or flapping deformations, Published by Elsevier Science Ltd.

The role of ocean climate data in operational Naval oceanography

NASA Technical Reports Server (NTRS)

Chesbrough, Radm G.

1992-01-01

Local application of global-scale models describes the U.S. Navy's basic philosophy for operational oceanography in support of fleet operations. Real-time data, climatologies, coupled air/ocean models, and large scale computers are the essential components of the Navy's system for providing the war fighters with the performance predictions and tactical decision aids they need to operate safely and efficiently. In peacetime, these oceanographic predictions are important for safety of navigation and flight. The paucity and uneven distribution of real-time data mean we have to fall back on climatology to provide the basic data to operate our models. The Navy is both a producer and user of climatologies; it provides observations to the national archives and in turn employs data from these archives to establish data bases. Suggestions for future improvements to ocean climate data are offered.

Achieving "organic compositionality" through self-organization: reviews on brain-inspired robotics experiments.

PubMed

Tani, Jun; Nishimoto, Ryunosuke; Paine, Rainer W

2008-05-01

The current paper examines how compositional structures can self-organize in given neuro-dynamical systems when robot agents are forced to learn multiple goal-directed behaviors simultaneously. Firstly, we propose a basic model accounting for the roles of parietal-premotor interactions for representing skills for goal-directed behaviors. The basic model had been implemented in a set of robotics experiments employing different neural network architectures. The comparative reviews among those experimental results address the issues of local vs distributed representations in representing behavior and the effectiveness of level structures associated with different sensory-motor articulation mechanisms. It is concluded that the compositional structures can be acquired "organically" by achieving generalization in learning and by capturing the contextual nature of skilled behaviors under specific conditions. Furthermore, the paper discusses possible feedback for empirical neuroscience studies in the future.

On radiating baroclinic instability of zonally varying flow

NASA Technical Reports Server (NTRS)

Finley, Catherine A.; Nathan, Terrence R.

1993-01-01

A quasi-geostrophic, two-layer, beta-plane model is used to study the baroclinic instability characteristics of a zonally inhomogeneous flow. It is assumed that the disturbance varied slowly in the cross-stream direction, and the stability problem was formulated as a 1D initial value problem. Emphasis is placed on determining how the vertically averaged wind, local maximum in vertical wind shear, and length of the locally supercritical region combine to yield local instabilities. Analysis of the local disturbance energetics reveals that, for slowly varying basic states, the baroclinic energy conversion predominates within the locally unstable region. Using calculations of the basic state tendencies, it is shown that the net effect of the local instabilities is to redistribute energy from the baroclinic to the barotropic component of the basic state flow.

Enhancing Basic Skill Levels of Marketing and Distributive Education Students Identified as Disadvantaged--A Tutorial Approach. Final Report, July 1, 1980-June 30, 1981.

ERIC Educational Resources Information Center

Wells, Randall L.

A project was undertaken to enhance the basic skill levels of marketing and distributive education students identified as disadvantaged by using a tutorial approach. After determining the basic skill competencies needed for students to succeed in marketing and distributive education, project staff identified existing materials in the areas of math…

An Integrated Wireless Wearable Sensor System for Posture Recognition and Indoor Localization.

PubMed

Huang, Jian; Yu, Xiaoqiang; Wang, Yuan; Xiao, Xiling

2016-10-31

In order to provide better monitoring for the elderly or patients, we developed an integrated wireless wearable sensor system that can realize posture recognition and indoor localization in real time. Five designed sensor nodes which are respectively fixed on lower limbs and a standard Kalman filter are used to acquire basic attitude data. After the attitude angles of five body segments (two thighs, two shanks and the waist) are obtained, the pitch angles of the left thigh and waist are used to realize posture recognition. Based on all these attitude angles of body segments, we can also calculate the coordinates of six lower limb joints (two hip joints, two knee joints and two ankle joints). Then, a novel relative localization algorithm based on step length is proposed to realize the indoor localization of the user. Several sparsely distributed active Radio Frequency Identification (RFID) tags are used to correct the accumulative error in the relative localization algorithm and a set-membership filter is applied to realize the data fusion. The experimental results verify the effectiveness of the proposed algorithms.

An Integrated Wireless Wearable Sensor System for Posture Recognition and Indoor Localization

PubMed Central

Huang, Jian; Yu, Xiaoqiang; Wang, Yuan; Xiao, Xiling

2016-01-01

In order to provide better monitoring for the elderly or patients, we developed an integrated wireless wearable sensor system that can realize posture recognition and indoor localization in real time. Five designed sensor nodes which are respectively fixed on lower limbs and a standard Kalman filter are used to acquire basic attitude data. After the attitude angles of five body segments (two thighs, two shanks and the waist) are obtained, the pitch angles of the left thigh and waist are used to realize posture recognition. Based on all these attitude angles of body segments, we can also calculate the coordinates of six lower limb joints (two hip joints, two knee joints and two ankle joints). Then, a novel relative localization algorithm based on step length is proposed to realize the indoor localization of the user. Several sparsely distributed active Radio Frequency Identification (RFID) tags are used to correct the accumulative error in the relative localization algorithm and a set-membership filter is applied to realize the data fusion. The experimental results verify the effectiveness of the proposed algorithms. PMID:27809230

DC Microgrids–Part I: A Review of Control Strategies and Stabilization Techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dragicevic, Tomislav; Lu, Xiaonan; Vasquez, Juan

2015-01-01

This paper presents a review of control strategies, stability analysis, and stabilization techniques for dc microgrids (MGs). Overall control is systematically classified into local and coordinated control levels according to respective functionalities in each level. As opposed to local control, which relies only on local measurements, some line of communication between units needs to be made available in order to achieve the coordinated control. Depending on the communication method, three basic coordinated control strategies can be distinguished, i.e., decentralized, centralized, and distributed control. Decentralized control can be regarded as an extension of the local control since it is also basedmore » exclusively on local measurements. In contrast, centralized and distributed control strategies rely on digital communication technologies. A number of approaches using these three coordinated control strategies to achieve various control objectives are reviewed in this paper. Moreover, properties of dc MG dynamics and stability are discussed. This paper illustrates that tightly regulated point-of-load converters tend to reduce the stability margins of the system since they introduce negative impedances, which can potentially oscillate with lightly damped power supply input filters. It is also demonstrated that how the stability of the whole system is defined by the relationship of the source and load impedances, referred to as the minor loop gain. Several prominent specifications for the minor loop gain are reviewed. Finally, a number of active stabilization techniques are presented.« less

Performance analysis for IEEE 802.11 distributed coordination function in radio-over-fiber-based distributed antenna systems.

PubMed

Fan, Yuting; Li, Jianqiang; Xu, Kun; Chen, Hao; Lu, Xun; Dai, Yitang; Yin, Feifei; Ji, Yuefeng; Lin, Jintong

2013-09-09

In this paper, we analyze the performance of IEEE 802.11 distributed coordination function in simulcast radio-over-fiber-based distributed antenna systems (RoF-DASs) where multiple remote antenna units (RAUs) are connected to one wireless local-area network (WLAN) access point (AP) with different-length fiber links. We also present an analytical model to evaluate the throughput of the systems in the presence of both the inter-RAU hidden-node problem and fiber-length difference effect. In the model, the unequal delay induced by different fiber length is involved both in the backoff stage and in the calculation of Ts and Tc, which are the period of time when the channel is sensed busy due to a successful transmission or a collision. The throughput performances of WLAN-RoF-DAS in both basic access and request to send/clear to send (RTS/CTS) exchange modes are evaluated with the help of the derived model.

A self-organized criticality model for ion temperature gradient mode driven turbulence in confined plasma

NASA Astrophysics Data System (ADS)

Isliker, H.; Pisokas, Th.; Strintzi, D.; Vlahos, L.

2010-08-01

A new self-organized criticality (SOC) model is introduced in the form of a cellular automaton (CA) for ion temperature gradient (ITG) mode driven turbulence in fusion plasmas. Main characteristics of the model are that it is constructed in terms of the actual physical variable, the ion temperature, and that the temporal evolution of the CA, which necessarily is in the form of rules, mimics actual physical processes as they are considered to be active in the system, i.e., a heating process and a local diffusive process that sets on if a threshold in the normalized ITG R /LT is exceeded. The model reaches the SOC state and yields ion temperature profiles of exponential shape, which exhibit very high stiffness, in that they basically are independent of the loading pattern applied. This implies that there is anomalous heat transport present in the system, despite the fact that diffusion at the local level is imposed to be of a normal kind. The distributions of the heat fluxes in the system and of the heat out-fluxes are of power-law shape. The basic properties of the model are in good qualitative agreement with experimental results.

New interpretation of data of the Earth's solid core

NASA Astrophysics Data System (ADS)

Guliyev, H. H.

2017-06-01

The commonly accepted scientific opinions on the inner core as the deformable solid globe are based on the solution of the problem on the distribution of elastic parameters in the inner structures of the Earth. The given solution is obtained within the necessary integral conditions on its self-weight, moment of inertia concerning the axes of rotation and periods of free oscillations of the Earth. It is shown that this solution does not satisfy the mechanics of the deformable solid body with sufficient local conditions following from basic principles concerning the strength, stability and actuality of velocities of propagation of elastic waves. The violation of local conditions shows that the inner core cannot exist in the form of the deformable solid body within the commonly accepted elastic parameters.

Choroid plexus epithelial cells express the adhesion protein P-cadherin at cell-cell contacts and syntaxin-4 in the luminal membrane domain.

PubMed

Christensen, Inga Baasch; Mogensen, Esben Nees; Damkier, Helle Hasager; Praetorius, Jeppe

2018-05-01

The choroid plexus epithelial cells (CPECs) belong to a small group of polarized cells, where the Na + -K + -ATPase is expressed in the luminal membrane. The basic polarity of the cells is, therefore, still debated. We investigated the subcellular distribution of an array of proteins known to play fundamental roles either in establishing and maintaining basic cell polarity or in the polarized delivery and recycling of plasma membrane proteins. Immunofluorescence histochemical analysis was applied to determine the subcellular localization of apical and basolateral membrane determinants. Mass spectrometry analysis of CPECs isolated by fluorescence-activated cell sorting was applied to determine the expression of specific forms of the proteins. CPECs mainly express the cell-adhesive P-cadherin, which is localized to the lateral membranes. Proteins belonging to the Crumbs and partitioning defective (Par) protein complexes were all localized to the luminal membrane domain. Par-1 and the Scribble complex were localized to the basolateral membrane domain. Lethal(2) giant larvae homolog 2 (Lgl2) labeling was preferentially observed in the luminal membrane domain. Phosphatidylinositol 3,4,5-trisphosphate (PIP 3 ) was immunolocalized to the basolateral membrane domain, while phosphatidylinositol 4,5-bisphosphate (PIP 2 ) staining was most prominent in the luminal membrane domain along with the PIP 3 phosphatase, Pten. The apical target-SNARE syntaxin-3 and the basolateral target-SNARE syntaxin-4 were both localized to the apical membrane domain in CPECs, which lack cellular expression of the clathrin adaptor protein AP-1B for basolateral protein recycling. In conclusion, the CPECs are conventionally polarized, but express P-cadherin at cell-cell contacts, and Lgl2 and syntaxin-4 in the luminal plasma membrane domain.

The seesaw space, a vector space to identify and characterize large-scale structures at 1 AU

NASA Astrophysics Data System (ADS)

Lara, A.; Niembro, T.

2017-12-01

We introduce the seesaw space, an orthonormal space formed by the local and the global fluctuations of any of the four basic solar parameters: velocity, density, magnetic field and temperature at any heliospheric distance. The fluctuations compare the standard deviation of a moving average of three hours against the running average of the parameter in a month (consider as the local fluctuations) and in a year (global fluctuations) We created this new vectorial spaces to identify the arrival of transients to any spacecraft without the need of an observer. We applied our method to the one-minute resolution data of WIND spacecraft from 1996 to 2016. To study the behavior of the seesaw norms in terms of the solar cycle, we computed annual histograms and fixed piecewise functions formed by two log-normal distributions and observed that one of the distributions is due to large-scale structures while the other to the ambient solar wind. The norm values in which the piecewise functions change vary in terms of the solar cycle. We compared the seesaw norms of each of the basic parameters due to the arrival of coronal mass ejections, co-rotating interaction regions and sector boundaries reported in literature. High seesaw norms are due to large-scale structures. We found three critical values of the norms that can be used to determined the arrival of coronal mass ejections. We present as well general comparisons of the norms during the two maxima and the minimum solar cycle periods and the differences of the norms due to large-scale structures depending on each period.

A comparison of experimental and calculated thin-shell leading-edge buckling due to thermal stresses

NASA Technical Reports Server (NTRS)

Jenkins, Jerald M.

1988-01-01

High-temperature thin-shell leading-edge buckling test data are analyzed using NASA structural analysis (NASTRAN) as a finite element tool for predicting thermal buckling characteristics. Buckling points are predicted for several combinations of edge boundary conditions. The problem of relating the appropriate plate area to the edge stress distribution and the stress gradient is addressed in terms of analysis assumptions. Local plasticity was found to occur on the specimen analyzed, and this tended to simplify the basic problem since it effectively equalized the stress gradient from loaded edge to loaded edge. The initial loading was found to be difficult to select for the buckling analysis because of the transient nature of thermal stress. Multiple initial model loadings are likely required for complicated thermal stress time histories before a pertinent finite element buckling analysis can be achieved. The basic mode shapes determined from experimentation were correctly identified from computation.

An intrinsic poperty of memory of the Cellular automaton infrastructure of Nature leading to the organization of the physical world as an Internet o things; TOE = IOT

NASA Astrophysics Data System (ADS)

Berkovich, Simon

2015-04-01

The undamental advantage of a Cellular automaton construction foris that it can be viewed as an undetectable absolute frame o reference, in accordance with Lorentz-Poincare's interpretation.. The cellular automaton model for physical poblems comes upon two basic hurdles: (1) How to find the Elemental Rule that, and how to get non-locality from local transformations. Both problems are resolved considering the transfomation rule of mutual distributed synchronization Actually any information proessing device starts with a clocking system. and it turns out that ``All physical phenomena are different aspects of the high-level description of distributed mutual synchronization in a network of digital clocks''. Non-locality comes from two hugely different time-scales of signaling.. The universe is acombinines information and matter processes, These fast spreading diffusion wave solutions create the mechanism of the Holographic Universe. And thirdly Disengaged from synchronization, circular counters can perform memory functions by retaining phases of their oscillations, an idea of Von Neumann'. Thus, the suggested model generates the necessary constructs for the physical world as an Internet of Things. Life emerges due to the specifics of macromolecules that serve as communication means, with the holographic memory...

The Principles of Buoyancy in Marine Fish Eggs and Their Vertical Distributions across the World Oceans

PubMed Central

Sundby, Svein; Kristiansen, Trond

2015-01-01

Buoyancy acting on plankton, i.e. the difference in specific gravity between plankton and the ambient water, is a function of salinity and temperature. From specific gravity measurements of marine fish eggs salinity appears to be the only determinant of the buoyancy indicating that the thermal expansions of the fish egg and the ambient seawater are equal. We analyze the mechanisms behind thermal expansion in fish eggs in order to determine to what extent it can be justified to neglect the effects of temperature on buoyancy. Our results confirm the earlier assumptions that salinity is the basic determinant on buoyancy in marine fish eggs that, in turn, influence the vertical distributions and, consequently, the dispersal of fish eggs from the spawning areas. Fish populations have adapted accordingly by producing egg specific gravities that tune the egg buoyancy to create specific vertical distributions for each local population. A wide variety of buoyancy adaptations are found among fish populations. The ambient physical conditions at the spawning sites form a basic constraint for adaptation. In coastal regions where salinity increases with depth, and where the major fraction of the fish stocks spawns, pelagic and mesopelagic egg distributions dominate. However, in the larger part of worlds’ oceans salinity decreases with depth resulting in different egg distributions. Here, the principles of vertical distributions of fish eggs in the world oceans are presented in an overarching framework presenting the basic differences between regions, mainly coastal, where salinity increases with depth and the major part of the world oceans where salinity decreases with depth. We show that under these latter conditions, steady-state vertical distribution of mesopelagic fish eggs cannot exist as it does in most coastal regions. In fact, a critical spawning depth must exist where spawning below this depth threshold results in eggs sinking out of the water column and become lost for recruitment to the population. An example of adaptation to such conditions is Cape hake spawning above the critical layer in the Northern Benguela upwelling ecosystem. The eggs rise slowly in the onshore subsurface current below the Ekman layer, hence being advected inshore where the hatched larvae concentrate with optimal feeding conditions. PMID:26465149

Statistics of the Work done in a Quantum Quench

NASA Astrophysics Data System (ADS)

Silva, Alessandro

2009-03-01

The quantum quench, i.e. a rapid change in time of a control parameter of a quantum system, is the simplest paradigm of non-equilibrium process, completely analogous to a standard thermodynamic transformation. The dynamics following a quantum quench is particularly interesting in strongly correlated quantum systems, most prominently when the quench in performed across a quantum critical point. In this talk I will present a way to characterize the physics of quantum quenches by looking at the statistics of a basic thermodynamic variable: the work done on the system by changing its parameters [1]. I will first elucidate the relation between the probability distribution of the work, quantum Jarzynski equalities, and the Loschmidt echo, a quantity that emerges usually in the context of dephasing. Using this connection, I will then characterize the statistics of the work done on a Quantum Ising chain by quenching locally or globally the transverse field. I will then show that for global quenches the presence of a quantum critical point results in singularities of the moments of the distribution, while, for local quenches starting at criticality, the probability distribution itself displays an interesting edge singularity. The results of a similar analysis for other systems will be discussed. [4pt] [1] A. Silva, Phys. Rev. Lett. 101, 120603 (2008).

The Quality of a "Local Values Based" Fuctional Literacy Program: Its Contribution to the Improvement of the Learner's Basic Competencies

ERIC Educational Resources Information Center

Wahyudin, Uyu

2015-01-01

Literacy facilitators across the archipelago are currently faced with the challenge to integrate local values in functional literacy education programs, because its integration is a new aspect. This makes localized literacy content a hard thing to implement. Yet, if properly conducted, it can lead to improved learner's basic competencies. In an…

Basic leucine zipper family in barley: genome-wide characterization of members and expression analysis.

PubMed

Pourabed, Ehsan; Ghane Golmohamadi, Farzan; Soleymani Monfared, Peyman; Razavi, Seyed Morteza; Shobbar, Zahra-Sadat

2015-01-01

The basic leucine zipper (bZIP) family is one of the largest and most diverse transcription factors in eukaryotes participating in many essential plant processes. We identified 141 bZIP proteins encoded by 89 genes from the Hordeum vulgare genome. HvbZIPs were classified into 11 groups based on their DNA-binding motif. Amino acid sequence alignment of the HvbZIPs basic-hinge regions revealed some highly conserved residues within each group. The leucine zipper heptads were analyzed predicting their dimerization properties. 34 conserved motifs were identified outside the bZIP domain. Phylogenetic analysis indicated that major diversification within the bZIP family predated the monocot/dicot divergence, although intra-species duplication and parallel evolution seems to be occurred afterward. Localization of HvbZIPs on the barley chromosomes revealed that different groups have been distributed on seven chromosomes of barley. Six types of intron pattern were detected within the basic-hinge regions. Most of the detected cis-elements in the promoter and UTR sequences were involved in seed development or abiotic stress response. Microarray data analysis revealed differential expression pattern of HvbZIPs in response to ABA treatment, drought, and cold stresses and during barley grain development and germination. This information would be helpful for functional characterization of bZIP transcription factors in barley.

A survey of the alpha-nucleon interaction

NASA Astrophysics Data System (ADS)

Ali, S.; Ahmad, A. A. Z.; Ferdous, N.

1985-10-01

This paper gives a survey of the alpha-nucleon interaction and then describes experimental work on angular distributions of differential scattering cross sections and polarizations in proton-alpha and neutron-alpha scattering. The phenomenological approach, which includes the study of both local and nonlocal potentials reproducing the experimental alpha-nucleon scattering data, is discussed. Basic studies of the alpha-nucleon interaction attempting to build an interaction between an alpha particle and a nucleon from first principles are then described. The authors then present a critical discussion of the results with some concluding remarks suggesting the direction for further investigation.

Surface Water Records of California, 1962; Volume 2: Northern Great Basin and Central Valley

USGS Publications Warehouse

1962-01-01

Beginning with the 1961 water year, streamflow records and related data are being released by the Geological Survey in annual reports on a State-boundary basis. Distribution of these basic data reports is limited and primarily for local needs. The records later will be published in Geological Survey water-supply papers at 5-year intervals. These 5-year water-supply papers will show daily discharge and will be compiled on the same geographical areas previously used for the annual series; however, some of the 14 parts of conterminous United States will be further subdivided.

Localization of eosinophil granule major basic protein in paracoccidioidomycosis lesions.

PubMed

Wagner, J M; Franco, M; Kephart, G M; Gleich, G J

1998-07-01

Paracoccidioidomycosis is a chronic granulomatous disease caused by the fungus Paracoccidioides brasiliensis. Although eosinophils have long been associated with the immune defense against helminths, the role of eosinophils in the immune response to fungal diseases is not as well studied. The eosinophil granule major basic protein is toxic to helminths and mammalian cells in vitro, and its release has been used as a marker of eosinophil localization and degranulation. To determine whether eosinophil infiltration and degranulation, as evidenced by the deposition of major basic protein, occur in lesions of P. brasiliensis, we used an immunofluorescence technique to localize the P. brasiliensis organisms and eosinophils and major basic protein. Initially, all tissues were stained with polyclonal antibody to major basic protein; subsequently, colocalization of major basic protein and P. brasiliensis by double staining with mouse and rabbit antibodies, respectively, was performed. Nine biopsy tissues from seven patients were analyzed. All nine biopsies showed infiltration of intact eosinophils using both the monoclonal and the polyclonal anti-major basic protein antibodies, along with the presence of P. brasiliensis. Furthermore, using the polyclonal anti-major basic protein antibody, nine of nine tissues showed extracellular major basic protein deposition (granular or diffuse fluorescence staining outside of intact eosinophils). The double staining procedure using the anti-major basic protein monoclonal antibody showed extracellular deposition in five of eight biopsies; in these five biopsies, approximately 60% of the areas containing P. brasiliensis had extracellular major basic protein deposited on the organisms. These observations support the hypothesis that the eosinophil, through toxic granule proteins such as major basic protein, participates in the pathophysiology of paracoccidioidomycosis.

Efficient iris recognition by characterizing key local variations.

PubMed

Ma, Li; Tan, Tieniu; Wang, Yunhong; Zhang, Dexin

2004-06-01

Unlike other biometrics such as fingerprints and face, the distinct aspect of iris comes from randomly distributed features. This leads to its high reliability for personal identification, and at the same time, the difficulty in effectively representing such details in an image. This paper describes an efficient algorithm for iris recognition by characterizing key local variations. The basic idea is that local sharp variation points, denoting the appearing or vanishing of an important image structure, are utilized to represent the characteristics of the iris. The whole procedure of feature extraction includes two steps: 1) a set of one-dimensional intensity signals is constructed to effectively characterize the most important information of the original two-dimensional image; 2) using a particular class of wavelets, a position sequence of local sharp variation points in such signals is recorded as features. We also present a fast matching scheme based on exclusive OR operation to compute the similarity between a pair of position sequences. Experimental results on 2255 iris images show that the performance of the proposed method is encouraging and comparable to the best iris recognition algorithm found in the current literature.

Critical Review of Technical Questions Facing Low Impact Development and Green Infrastructure: A Perspective from the Great Plains.

PubMed

Vogel, Jason R; Moore, Trisha L; Coffman, Reid R; Rodie, Steven N; Hutchinson, Stacy L; McDonough, Kelsey R; McLemore, Alex J; McMaine, John T

2015-09-01

Since its inception, Low Impact Development (LID) has become part of urban stormwater management across the United States, marking progress in the gradual transition from centralized to distributed runoff management infrastructure. The ultimate goal of LID is full, cost-effective implementation to maximize watershed-scale ecosystem services and enhance resilience. To reach that goal in the Great Plains, the multi-disciplinary author team presents this critical review based on thirteen technical questions within the context of regional climate and socioeconomics across increasing complexities in scale and function. Although some progress has been made, much remains to be done including continued basic and applied research, development of local LID design specifications, local demonstrations, and identifying funding mechanisms for these solutions. Within the Great Plains and beyond, by addressing these technical questions within a local context, the goal of widespread acceptance of LID can be achieved, resulting in more effective and resilient stormwater management.

Equipment management user's handbook for property custodians

NASA Technical Reports Server (NTRS)

1993-01-01

The NASA Equipment Management User's Handbook for Property Custodians is issued as an instructional guide for personnel designated as property custodians and technical personnel involved in the acquisition, management, and use of NASA-owned equipment. This handbook provides general information and basic operational procedures for processing equipment transactions through the agency-wide NASA Equipment Management System (NEMS). Each NASA installation must prepare supplementary instructions for local requirements beyond the scope of NASA-wide policies and procedures contained herein, or as specified for local implementation in NHB 4200.1, 'NASA Equipment Management Manual.' NHB 4200.1 sets forth policy, uniform performance standards, and procedural guidance to NASA personnel for the acquisition, management, and use of NASA-owned equipment. This handbook is a controlled document, issued in loose-leaf form and revised by page changes. Additional copies for internal use may be obtained through normal distribution.

Localization and phosphorylation of Plasmodium falciparum nicotinamide/nicotinate mononucleotide adenylyltransferase (PfNMNAT) in intraerythrocytic stages.

PubMed

Nieto, Carlos A; Sánchez, Lina M; Sánchez, Diana M; Díaz, Gonzalo J; Ramírez, María H

2018-04-11

Nicotinamide adenine dinucleotide (NAD+) is an essential molecule in the energy metabolism of living beings, and it has various cellular functions. The main enzyme in the biosynthesis of this nucleotide is nicotinamide/nicotinate mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1/18) because it is the convergence point for all known biosynthetic pathways. NMNATs have divergences in both the number of isoforms detected and their distribution, depending on the organism. In the laboratory of basic research in biochemistry (LIBBIQ: acronym in Spanish) the NMNATs of protozoan parasites (Leishmania braziliensis, Plasmodium falciparum, Trypanosoma cruzi, and Giardia duodenalis) have been studied, analysing their catalytic properties through the use of proteins. Recombinants and their cellular distribution essentially. In 2014, O'Hara et al. determined the cytoplasmic localization of NMNAT of P. falciparum, using a transgene coupled to GFP, however, the addition of labels to the study protein can modify several of its characteristics, including its sub-cellular localization. This study confirms the cytoplasmic localization of this protein in the parasite through recognition of the endogenous protein in the different stages of the asexual life cycle. Additionally, the study found that PfNMNAT could be a phosphorylation target at serine, tyrosine and threonine residues, and it shows variations during the asexual life cycle. These experiments confirmed that the parasite is situated in the cytoplasm, fulfilling the required functions of NAD+ in this compartment, the PfNMNAT is regulated in post-transcription processes, and can be regulated by phosphorylation in its residues.

A communication efficient and scalable distributed data mining for the astronomical data

NASA Astrophysics Data System (ADS)

Govada, A.; Sahay, S. K.

2016-07-01

In 2020, ∼60PB of archived data will be accessible to the astronomers. But to analyze such a paramount data will be a challenging task. This is basically due to the computational model used to download the data from complex geographically distributed archives to a central site and then analyzing it in the local systems. Because the data has to be downloaded to the central site, the network BW limitation will be a hindrance for the scientific discoveries. Also analyzing this PB-scale on local machines in a centralized manner is challenging. In this, virtual observatory is a step towards this problem, however, it does not provide the data mining model (Zhang et al., 2004). Adding the distributed data mining layer to the VO can be the solution in which the knowledge can be downloaded by the astronomers instead the raw data and thereafter astronomers can either reconstruct the data back from the downloaded knowledge or use the knowledge directly for further analysis. Therefore, in this paper, we present Distributed Load Balancing Principal Component Analysis for optimally distributing the computation among the available nodes to minimize the transmission cost and downloading cost for the end user. The experimental analysis is done with Fundamental Plane (FP) data, Gadotti data and complex Mfeat data. In terms of transmission cost, our approach performs better than Qi et al. and Yue et al. The analysis shows that with the complex Mfeat data ∼90% downloading cost can be reduced for the end user with the negligible loss in accuracy.

Justification for, and design of, an economical programmable multiple flight simulator

NASA Technical Reports Server (NTRS)

Kreifeldt, J. G.; Wittenber, J.; Macdonald, G.

1981-01-01

The considered research interests in air traffic control (ATC) studies revolve about the concept of distributed ATC management based on the assumption that the pilot has a cockpit display of traffic and navigation information (CDTI) via CRT graphics. The basic premise is that a CDTI equipped pilot can, in coordination with a controller, manage a part of his local traffic situation thereby improving important aspects of ATC performance. A modularly designed programmable flight simulator system is prototyped as a means of providing an economical facility of up to eight simulators to interface with a mainframe/graphics system for ATC experimentation, particularly CDTI-distributed management in which pilot-pilot interaction can have a determining effect on system performance. Need for a multiman simulator facility is predicted on results from an earlier three simulator facility.

Evaluation of the Thermodynamic Consistency of Closure Approximations in Several Models Proposed for the Description of Liquid Crystalline Dynamics

NASA Astrophysics Data System (ADS)

Edwards, Brian J.

2002-05-01

Given the premise that a set of dynamical equations must possess a definite, underlying mathematical structure to ensure local and global thermodynamic stability, as has been well documented, several different models for describing liquid crystalline dynamics are examined with respect to said structure. These models, each derived during the past several years using a specific closure approximation for the fourth moment of the distribution function in Doi's rigid rod theory, are all shown to be inconsistent with this basic mathematical structure. The source of this inconsistency lies in Doi's expressions for the extra stress tensor and temporal evolution of the order parameter, which are rederived herein using a transformation that allows for internal compatibility with the underlying mathematical structure that is present on the distribution function level of description.

The Rise and Attenuation of the Basic Education Programme (BEP) in Botswana: A Global-Local Dialectic Approach

ERIC Educational Resources Information Center

Tabulawa, Richard

2011-01-01

Using a global-local dialectic approach, this paper traces the rise of the basic education programme in the 1980s and 1990s in Botswana and its subsequent attenuation in the 2000s. Amongst the local forces that led to the rise of BEP were Botswana's political project of nation-building; the country's dire human resources situation in the decades…

Kappa Distribution in a Homogeneous Medium: Adiabatic Limit of a Super-diffusive Process?

NASA Astrophysics Data System (ADS)

Roth, I.

2015-12-01

The classical statistical theory predicts that an ergodic, weakly interacting system like charged particles in the presence of electromagnetic fields, performing Brownian motions (characterized by small range deviations in phase space and short-term microscopic memory), converges into the Gibbs-Boltzmann statistics. Observation of distributions with a kappa-power-law tails in homogeneous systems contradicts this prediction and necessitates a renewed analysis of the basic axioms of the diffusion process: characteristics of the transition probability density function (pdf) for a single interaction, with a possibility of non-Markovian process and non-local interaction. The non-local, Levy walk deviation is related to the non-extensive statistical framework. Particles bouncing along (solar) magnetic field with evolving pitch angles, phases and velocities, as they interact resonantly with waves, undergo energy changes at undetermined time intervals, satisfying these postulates. The dynamic evolution of a general continuous time random walk is determined by pdf of jumps and waiting times resulting in a fractional Fokker-Planck equation with non-integer derivatives whose solution is given by a Fox H-function. The resulting procedure involves the known, although not frequently used in physics fractional calculus, while the local, Markovian process recasts the evolution into the standard Fokker-Planck equation. Solution of the fractional Fokker-Planck equation with the help of Mellin transform and evaluation of its residues at the poles of its Gamma functions results in a slowly converging sum with power laws. It is suggested that these tails form the Kappa function. Gradual vs impulsive solar electron distributions serve as prototypes of this description.

47 CFR 32.5000 - Basic local service revenue.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SYSTEM OF ACCOUNTS FOR TELECOMMUNICATIONS COMPANIES Instructions For Revenue Accounts § 32.5000 Basic local service revenue. Class B telephone companies shall use this account for revenues of the type and character required of Class A companies in Accounts 5001 through 5060. [67 FR 5691, Feb. 6, 2002] ...

RCTS: A flexible environment for sensor integration and control of robot systems; the distributed processing approach

NASA Technical Reports Server (NTRS)

Allard, R.; Mack, B.; Bayoumi, M. M.

1989-01-01

Most robot systems lack a suitable hardware and software environment for the efficient research of new control and sensing schemes. Typically, engineers and researchers need to be experts in control, sensing, programming, communication and robotics in order to implement, integrate and test new ideas in a robot system. In order to reduce this time, the Robot Controller Test Station (RCTS) has been developed. It uses a modular hardware and software architecture allowing easy physical and functional reconfiguration of a robot. This is accomplished by emphasizing four major design goals: flexibility, portability, ease of use, and ease of modification. An enhanced distributed processing version of RCTS is described. It features an expanded and more flexible communication system design. Distributed processing results in the availability of more local computing power and retains the low cost of microprocessors. A large number of possible communication, control and sensing schemes can therefore be easily introduced and tested, using the same basic software structure.

The bZIP dimer localizes at DNA full-sites where each basic region can alternately translocate and bind to subsites at the half-site

PubMed Central

Chan, I-San; Al-Sarraj, Taufik; Shahravan, S. Hesam; Fedorova, Anna V.; Shin, Jumi A.

2012-01-01

Crystal structures of the GCN4 bZIP (basic region/leucine zipper) with the AP-1 or CRE site show how each GCN4 basic region binds to a 4-bp cognate half-site as a single DNA target; however, this may not always fully describe how bZIP proteins interact with their target sites. Previously, we showed that the GCN4 basic region interacts with all 5 bp in half-site TTGCG (termed 5H-LR), and that 5H-LR comprises two 4-bp subsites, TTGC and TGCG, which individually are also target sites of the basic region. In this work, we explored how the basic region interacts with 5H-LR when the bZIP dimer localizes to full-sites. Using AMBER molecular modeling, we simulated GCN4 bZIP complexes with full-sites containing 5H-LR to investigate in silico the interface between the basic region and 5H-LR. We also performed in vitro investigation of bZIP–DNA interactions at a number of full-sites that contain 5H-LR vs. either subsite: we analyzed results from DNase I footprinting and electrophoretic mobility shift assay (EMSA) and from EMSA titrations to quantify binding affinities. Our computational and experimental results together support a highly dynamic DNA-binding model: when a bZIP dimer localizes to its target full-site, the basic region can alternately recognize either subsite as a distinct target at 5H-LR and translocate between the subsites, potentially by sliding and hopping. This model provides added insights into how α-helical DNA-binding domains of transcription factors can localize to their gene regulatory sequences in vivo. PMID:22856882

The bZIP dimer localizes at DNA full-sites where each basic region can alternately translocate and bind to subsites at the half-site.

PubMed

Chan, I-San; Al-Sarraj, Taufik; Shahravan, S Hesam; Fedorova, Anna V; Shin, Jumi A

2012-08-21

Crystal structures of the GCN4 bZIP (basic region/leucine zipper) with the AP-1 or CRE site show how each GCN4 basic region binds to a 4 bp cognate half-site as a single DNA target; however, this may not always fully describe how bZIP proteins interact with their target sites. Previously, we showed that the GCN4 basic region interacts with all 5 bp in half-site TTGCG (termed 5H-LR) and that 5H-LR comprises two 4 bp subsites, TTGC and TGCG, which individually are also target sites of the basic region. In this work, we explore how the basic region interacts with 5H-LR when the bZIP dimer localizes to full-sites. Using AMBER molecular modeling, we simulated GCN4 bZIP complexes with full-sites containing 5H-LR to investigate in silico the interface between the basic region and 5H-LR. We also performed in vitro investigation of bZIP-DNA interactions at a number of full-sites that contain 5H-LR versus either subsite: we analyzed results from DNase I footprinting and electrophoretic mobility shift assay (EMSA) and from EMSA titrations to quantify binding affinities. Our computational and experimental results together support a highly dynamic DNA-binding model: when a bZIP dimer localizes to its target full-site, the basic region can alternately recognize either subsite as a distinct target at 5H-LR and translocate between the subsites, potentially by sliding and hopping. This model provides added insights into how α-helical DNA-binding domains of transcription factors can localize to their gene regulatory sequences in vivo.

Septal membrane localization by C-terminal amphipathic α-helices of MinD in Bacillus subtilis mutant cells lacking MinJ or DivIVA.

PubMed

Ishikawa, Kazuki; Matsuoka, Satoshi; Hara, Hiroshi; Matsumoto, Kouji

2017-10-18

The Min system, which inhibits assembly of the cytokinetic protein FtsZ, is largely responsible for positioning the division site in rod-shaped bacteria. It has been reported that MinJ, which bridges DivIVA and MinD, is targeted to the cell poles by an interaction with DivIVA, and that MinJ in turn recruits MinCD to the cell poles. MinC, however, is located primarily at active division sites at mid-cell when expressed from its native promoter. Surprisingly, we found that Bacillus subtilis MinD is located at nascent septal membranes and at an asymmetric site on lateral membranes between nascent septal membranes in filamentous cells lacking MinJ or DivIVA. Bacillus subtilis MinD has two amphipathic α-helices rich in basic amino acid residues at its C-terminus; one of these, named MTS1 here, is the counterpart of the membrane targeting sequence (MTS) in Escherichia coli MinD while the other, named MTS-like sequence (MTSL), is the nearest helix to MTS1. These amphipathic helices were located independently at nascent septal membranes in cells lacking MinJ or DivIVA, whereas elimination of the helices from the wild type protein reduced its localization considerably. MinD variants with altered MTS1 and MTSL, in which basic amino acid residues were replaced with proline or acidic residues, were not located at nascent septal membranes, indicating that the binding to the nascent septal membranes requires basic residues and a helical structure. The septal localization of MTSL, but not of MTS1, was dependent on host cell MinD. These results suggest that MinD is targeted to nascent septal membranes via its C-terminal amphipathic α-helices in B. subtilis cells lacking MinJ or DivIVA. Moreover, the diffuse distribution of MinD lacking both MTSs suggests that only a small fraction of MinD depends on MinJ for its localization to nascent septal membranes.

Modeling spatial accessibility to parks: a national study.

PubMed

Zhang, Xingyou; Lu, Hua; Holt, James B

2011-05-09

Parks provide ideal open spaces for leisure-time physical activity and important venues to promote physical activity. The spatial configuration of parks, the number of parks and their spatial distribution across neighborhood areas or local regions, represents the basic park access potential for their residential populations. A new measure of spatial access to parks, population-weighted distance (PWD) to parks, combines the advantages of current park access approaches and incorporates the information processing theory and probability access surface model to more accurately quantify residential population's potential spatial access to parks. The PWD was constructed at the basic level of US census geography - blocks - using US park and population data. This new measure of population park accessibility was aggregated to census tract, county, state and national levels. On average, US residential populations are expected to travel 6.7 miles to access their local neighborhood parks. There are significant differences in the PWD to local parks among states. The District of Columbia and Connecticut have the best access to local neighborhood parks with PWD of 0.6 miles and 1.8 miles, respectively. Alaska, Montana, and Wyoming have the largest PWDs of 62.0, 37.4, and 32.8 miles, respectively. Rural states in the western and Midwestern US have lower neighborhood park access, while urban states have relatively higher park access. The PWD to parks provides a consistent platform for evaluating spatial equity of park access and linking with population health outcomes. It could be an informative evaluation tool for health professionals and policy makers. This new method could be applied to quantify geographic accessibility of other types of services or destinations, such as food, alcohol, and tobacco outlets.

Chromated copper arsenate-treated fence posts in the agronomic landscape: soil properties controlling arsenic speciation and spatial distribution.

PubMed

Schwer Iii, Donald R; McNear, David H

2011-01-01

Soils adjacent to chromated copper arsenate (CCA)-treated fence posts along a fence line transecting different soil series, parent material, drainage classes, and slope were used to determine which soil properties had the most influence on As spatial distribution and speciation. Metal distribution was evaluated at macroscopic (total metal concentration contour maps) and microscopic scales (micro-synchrotron X-ray fluorescence maps), As speciation was determined using extended X-ray absorption fine structure spectroscopy, and redox status and a myriad of other basic soil properties were elucidated. All geochemical parameters measured point to a condition in which the mobilization of As becomes more favorable moving down the topographic gradient, likely resulting through competition (Meh-P, SOM), neutral or slightly basic pH, and redox conditions that are favorable for As mobilization (higher Fe(II) and total-Fe concentrations in water extracts). On the landscape scale, with hundreds of kilometers of fence, the arsenic loading into the soil can be substantial (∼8-12 kg km). Although a significant amount of the As is stable, extended use of CCA-treated wood has resulted in elevated As concentrations in the local environment, increasing the risk of exposure and ecosystem perturbation. Therefore, a move toward arsenic-free alternatives in agricultural applications for which it is currently permitted should be considered. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

10 CFR 431.385 - Cessation of distribution of a basic model of an electric motor.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Cessation of distribution of a basic model of an electric motor. 431.385 Section 431.385 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Enforcement § 431.385 Cessation of distribution of a...

Authors’ response: what are emotions and how are they created in the brain?

PubMed

Lindquist, Kristen A; Wager, Tor D; Bliss-Moreau, Eliza; Kober, Hedy; Barret, Lisa Feldman

2012-06-01

In our response, we clarify important theoretical differences between basic emotion and psychological construction approaches. We evaluate the empirical status of the basic emotion approach, addressing whether it requires brain localization, whether localization can be observed with better analytic tools, and whether evidence for basic emotions exists in other types of measures. We then revisit the issue of whether the key hypotheses of psychological construction are supported by our meta-analytic findings. We close by elaborating on commentator suggestions for future research.

47 CFR 76.945 - Procedures for Commission review of basic service rates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... schedule with the Commission within 30 days, with a copy to the local franchising authority. (b) Basic... cable operator and the local franchising authority. The cable operator may file an opposition within... franchising authority. (d) Filings proposing a rate not within the rate regulation standards of §§ 76.922 and...

Protonation Sites, Tandem Mass Spectrometry and Computational Calculations of o-Carbonyl Carbazolequinone Derivatives.

PubMed

Martínez-Cifuentes, Maximiliano; Clavijo-Allancan, Graciela; Zuñiga-Hormazabal, Pamela; Aranda, Braulio; Barriga, Andrés; Weiss-López, Boris; Araya-Maturana, Ramiro

2016-07-05

A series of a new type of tetracyclic carbazolequinones incorporating a carbonyl group at the ortho position relative to the quinone moiety was synthesized and analyzed by tandem electrospray ionization mass spectrometry (ESI/MS-MS), using Collision-Induced Dissociation (CID) to dissociate the protonated species. Theoretical parameters such as molecular electrostatic potential (MEP), local Fukui functions and local Parr function for electrophilic attack as well as proton affinity (PA) and gas phase basicity (GB), were used to explain the preferred protonation sites. Transition states of some main fragmentation routes were obtained and the energies calculated at density functional theory (DFT) B3LYP level were compared with the obtained by ab initio quadratic configuration interaction with single and double excitation (QCISD). The results are in accordance with the observed distribution of ions. The nature of the substituents in the aromatic ring has a notable impact on the fragmentation routes of the molecules.

Protonation Sites, Tandem Mass Spectrometry and Computational Calculations of o-Carbonyl Carbazolequinone Derivatives

PubMed Central

Martínez-Cifuentes, Maximiliano; Clavijo-Allancan, Graciela; Zuñiga-Hormazabal, Pamela; Aranda, Braulio; Barriga, Andrés; Weiss-López, Boris; Araya-Maturana, Ramiro

2016-01-01

A series of a new type of tetracyclic carbazolequinones incorporating a carbonyl group at the ortho position relative to the quinone moiety was synthesized and analyzed by tandem electrospray ionization mass spectrometry (ESI/MS-MS), using Collision-Induced Dissociation (CID) to dissociate the protonated species. Theoretical parameters such as molecular electrostatic potential (MEP), local Fukui functions and local Parr function for electrophilic attack as well as proton affinity (PA) and gas phase basicity (GB), were used to explain the preferred protonation sites. Transition states of some main fragmentation routes were obtained and the energies calculated at density functional theory (DFT) B3LYP level were compared with the obtained by ab initio quadratic configuration interaction with single and double excitation (QCISD). The results are in accordance with the observed distribution of ions. The nature of the substituents in the aromatic ring has a notable impact on the fragmentation routes of the molecules. PMID:27399676

Photonic multipartite entanglement conversion using nonlocal operations

NASA Astrophysics Data System (ADS)

Tashima, T.; Tame, M. S.; Özdemir, Ş. K.; Nori, F.; Koashi, M.; Weinfurter, H.

2016-11-01

We propose a simple setup for the conversion of multipartite entangled states in a quantum network with restricted access. The scheme uses nonlocal operations to enable the preparation of states that are inequivalent under local operations and classical communication, but most importantly does not require full access to the states. It is based on a flexible linear optical conversion gate that uses photons, which are ideally suited for distributed quantum computation and quantum communication in extended networks. In order to show the basic working principles of the gate, we focus on converting a four-qubit entangled cluster state to other locally inequivalent four-qubit states, such as the Greenberger-Horne-Zeilinger and symmetric Dicke states. We also show how the gate can be incorporated into extended graph state networks and can be used to generate variable entanglement and quantum correlations without entanglement but nonvanishing quantum discord.

Local heat transfer in turbine disk-cavities. II - Rotor cooling with radial location injection of coolant

NASA Astrophysics Data System (ADS)

Bunker, R. S.; Metzger, D. E.; Wittig, S.

1990-06-01

The detailed radial distributions of rotor heat-transfer coefficients for three basic disk-cavity geometries applicable to gas turbines are presented. The coefficients are obtained over a range of parameters including disk rotational Reynolds numbers of 200,000 to 50,000, rotor/stator spacing-to-disk ratios of 0.025 to 0.15, and jet mass flow rates between 0.10 and 0.40 times the turbulent pumped flow rate of a free disk. The effects of a parallel rotor are analyzed, and strong variations in local Nusselt numbers for all but the rotational speed are pointed out and compared with the associated hub-injection data from a previous study. It is demonstrated that the overall rotor heat transfer is optimized by either the hub injection or radial location injection of a coolant, dependent on the configuration.

6.7 radio sky mapping from satellites at very low frequencies

NASA Technical Reports Server (NTRS)

Storey, L. R. O.

1991-01-01

Wave Distribution Function (WDF) analysis is a procedure for making sky maps of the sources of natural electromagnetic waves in space plasmas, given local measurements of some or all of the three magnetic and three electric field components. The work that still needs to be done on this subject includes solving basic methodological problems, translating the solution into efficient algorithms, and embodying the algorithms in computer software. One important scientific use of WDF analysis is to identify the mode of origin of plasmaspheric hiss. Some of the data from the Japanese satellite Akebono (EXOS D) are likely to be suitable for this purpose.

Radio sky mapping from satellites at very low frequencies

NASA Technical Reports Server (NTRS)

Storey, L. R. O.

1991-01-01

Wave Distribution Function (WDF) analysis is a procedure for making sky maps of the sources of natural electromagnetic waves in space plasmas, given local measurements of some or all of the three magnetic and three electric field components. The work that still needs to be done on this subject includes solving basic methodological problems, translating the solution into efficient algorithms, and embodying the algorithms in computer software. One important scientific use of WDF analysis is to identify the mode of origin of plasmaspheric hiss. Some of the data from the Japanese satellite Akebono (EXOS D) are likely to be suitable for this purpose.

Some examples of exact and approximate solutions in small particle scattering - A progress report

NASA Technical Reports Server (NTRS)

Greenberg, J. M.

1974-01-01

The formulation of basic equations from which the scattering of radiation by a localized variation in a medium is discussed. These equations are developed in both the differential and the integral form. Primary interest is in the scattering of electromagnetic waves for which the solution of the vector wave equation with appropriate boundary conditions must be considered. Scalar scattering by an infinite homogeneous isotropic circular cylinder, and scattering of electromagnetic waves by infinite circular cylinders are treated, and the case of the finite circular cylinder is considered. A procedure is given for obtaining angular scattering distributions from spheroids.

A technique for plasma velocity-space cross-correlation

NASA Astrophysics Data System (ADS)

Mattingly, Sean; Skiff, Fred

2018-05-01

An advance in experimental plasma diagnostics is presented and used to make the first measurement of a plasma velocity-space cross-correlation matrix. The velocity space correlation function can detect collective fluctuations of plasmas through a localized measurement. An empirical decomposition, singular value decomposition, is applied to this Hermitian matrix in order to obtain the plasma fluctuation eigenmode structure on the ion distribution function. A basic theory is introduced and compared to the modes obtained by the experiment. A full characterization of these modes is left for future work, but an outline of this endeavor is provided. Finally, the requirements for this experimental technique in other plasma regimes are discussed.

Reconfigurable logic via gate controlled domain wall trajectory in magnetic network structure

PubMed Central

Murapaka, C.; Sethi, P.; Goolaup, S.; Lew, W. S.

2016-01-01

An all-magnetic logic scheme has the advantages of being non-volatile and energy efficient over the conventional transistor based logic devices. In this work, we present a reconfigurable magnetic logic device which is capable of performing all basic logic operations in a single device. The device exploits the deterministic trajectory of domain wall (DW) in ferromagnetic asymmetric branch structure for obtaining different output combinations. The programmability of the device is achieved by using a current-controlled magnetic gate, which generates a local Oersted field. The field generated at the magnetic gate influences the trajectory of the DW within the structure by exploiting its inherent transverse charge distribution. DW transformation from vortex to transverse configuration close to the output branch plays a pivotal role in governing the DW chirality and hence the output. By simply switching the current direction through the magnetic gate, two universal logic gate functionalities can be obtained in this device. Using magnetic force microscopy imaging and magnetoresistance measurements, all basic logic functionalities are demonstrated. PMID:26839036

Collaboration and decision making tools for mobile groups

NASA Astrophysics Data System (ADS)

Abrahamyan, Suren; Balyan, Serob; Ter-Minasyan, Harutyun; Degtyarev, Alexander

2017-12-01

Nowadays the use of distributed collaboration tools is widespread in many areas of people activity. But lack of mobility and certain equipment-dependency creates difficulties and decelerates development and integration of such technologies. Also mobile technologies allow individuals to interact with each other without need of traditional office spaces and regardless of location. Hence, realization of special infrastructures on mobile platforms with help of ad-hoc wireless local networks could eliminate hardware-attachment and be useful also in terms of scientific approach. Solutions from basic internet-messengers to complex software for online collaboration equipment in large-scale workgroups are implementations of tools based on mobile infrastructures. Despite growth of mobile infrastructures, applied distributed solutions in group decisionmaking and e-collaboration are not common. In this article we propose software complex for real-time collaboration and decision-making based on mobile devices, describe its architecture and evaluate performance.

The Association of Myosin IB with Actin Waves in Dictyostelium Requires Both the Plasma Membrane-Binding Site and Actin-Binding Region in the Myosin Tail

PubMed Central

Brzeska, Hanna; Pridham, Kevin; Chery, Godefroy; Titus, Margaret A.; Korn, Edward D.

2014-01-01

F-actin structures and their distribution are important determinants of the dynamic shapes and functions of eukaryotic cells. Actin waves are F-actin formations that move along the ventral cell membrane driven by actin polymerization. Dictyostelium myosin IB is associated with actin waves but its role in the wave is unknown. Myosin IB is a monomeric, non-filamentous myosin with a globular head that binds to F-actin and has motor activity, and a non-helical tail comprising a basic region, a glycine-proline-glutamine-rich region and an SH3-domain. The basic region binds to acidic phospholipids in the plasma membrane through a short basic-hydrophobic site and the Gly-Pro-Gln region binds F-actin. In the current work we found that both the basic-hydrophobic site in the basic region and the Gly-Pro-Gln region of the tail are required for the association of myosin IB with actin waves. This is the first evidence that the Gly-Pro-Gln region is required for localization of myosin IB to a specific actin structure in situ. The head is not required for myosin IB association with actin waves but binding of the head to F-actin strengthens the association of myosin IB with waves and stabilizes waves. Neither the SH3-domain nor motor activity is required for association of myosin IB with actin waves. We conclude that myosin IB contributes to anchoring actin waves to the plasma membranes by binding of the basic-hydrophobic site to acidic phospholipids in the plasma membrane and binding of the Gly-Pro-Gln region to F-actin in the wave. PMID:24747353

Effect of material inhomogeneity on the cyclic plastic deformation behavior at the microstructural level: micromechanics-based modeling of dual-phase steel

NASA Astrophysics Data System (ADS)

Paul, Surajit Kumar

2013-07-01

The microstructure of dual-phase (DP) steels typically consists of a soft ferrite matrix with dispersed islands of hard martensite phase. Due to the composite effect of ferrite and martensite, DP steels exhibit a unique combination of strain hardening, strength and ductility. A microstructure-based micromechanical modeling approach is adopted in this work to capture the tensile and cyclic plastic deformation behavior of DP steel. During tensile straining, strain incompatibility between the softer ferrite matrix and the harder martensite phase arises due to a difference in the flow characteristics of these two phases. Microstructural-level inhomogeneity serves as the initial imperfection, triggering strain incompatibility, strain partitioning and finally shear band localization during tensile straining. The local deformation in the ferrite phase is constrained by adjacent martensite islands, which locally results in stress triaxiality development in the ferrite phase. As the martensite distribution varies within the microstructure, the stress triaxiality also varies in a band within the microstructure. Inhomogeneous stress and strain distribution within the softer ferrite phase arises even during small tensile straining because of material inhomogeneity. The magnitude of cyclic plastic deformation within the softer ferrite phase also varies according to the stress distribution in the first-quarter cycle tensile loading. Accumulation of tensile/compressive plastic strain with number of cycles is noted in different locations within the ferrite phase during both symmetric stress and strain controlled cycling. The basic mode of cyclic plastic deformation in an inhomogeneous material is cyclic strain accumulation, i.e. ratcheting. Microstructural inhomogeneity results in cyclic strain accumulation in the aggregate DP material even in symmetric stress cycling.

10 CFR 431.36 - Compliance Certification.

Code of Federal Regulations, 2010 CFR

2010-01-01

... EQUIPMENT Electric Motors Certification § 431.36 Compliance Certification. (a) General. Beginning April 26, 2003, a manufacturer or private labeler shall not distribute in commerce any basic model of an electric...: (i) The nominal full load efficiency for each basic model of electric motor distributed is not less...

10 CFR 431.36 - Compliance Certification.

Code of Federal Regulations, 2012 CFR

2012-01-01

... EQUIPMENT Electric Motors Certification § 431.36 Compliance Certification. (a) General. Beginning April 26, 2003, a manufacturer or private labeler shall not distribute in commerce any basic model of an electric...: (i) The nominal full load efficiency for each basic model of electric motor distributed is not less...

Local structural aspects of metal-metal transition in IrTe2 from x-ray PDF

NASA Astrophysics Data System (ADS)

Yu, Runze; Abeykoon, Milinda; Zhou, Haidong; Yin, Weiguo; Bozin, Emil S.

Evolution of local atomic structure across the metal-metal transition in IrTe2 is explored by pair distribution function (PDF) analysis of x-ray total scattering data over 80 K

[Storage and transport of isolated M. tuberculosis at public and private health institutions in Japan].

PubMed

Ohkado, Akihiro; Takahashi, Chieko; Horiba, Masahide; Murase, Yoshiro; Mitarai, Satoshi

2008-08-01

To obtain basic data about the present practices on storage and transport of isolated M. tuberculosis at public and private health institutions in Japan. Survey forms regarding the practices on storage and transport of isolated M. tuberculosis were distributed and collected by post-mail in January 2007 to 76 local public health institutions, 145 public health centres, and 150 public or private hospitals. The questionnaire was adopted from the guidelines proposed by the Ministry of Health, Labour, and Welfare in 2006 on storage and transport of isolated M. tuberculosis. The respondents of the survey were as follows: 96.1% (73/76) from local public health institutions, 93.8% (136/145) from public health centres, and 73.3% (110/150) from hospitals. In general, local public health institutions conformed well to the proposed standards, however public health centres and hospitals were not compliant to some standards. Based on the survey conducted on the practice of storage and transport of isolated M. tuberculosis, certain discrepancy was found among public health centres and hospitals.

Subcellular Distribution and Chemical Forms of Pb in Corn: Strategies Underlying Tolerance in Pb Stress.

PubMed

Sun, Jianling; Luo, Liqiang

2018-06-22

Studying the accumulation position and forms of heavy metals (HMs) in organisms and cells is helpful to understand the transport process and detoxification mechanism. As typical HMs, lead (Pb) subcellular content, localization, and speciation of corn subcellular fractions were studied by a series of technologies, including transmission electron microscopy, inductively coupled plasma mass spectrometry, and X-ray absorption near edge structure. The results revealed that the electrodense granules of Pb were localized in the cell wall, intercellular space, and plasma membranes. About 71% Pb was localized at the cell wall and soluble fraction. In cell walls, the total amount of pyromorphite and Pb carbonate was about 80% and the remaining was Pb stearate. In the nuclear and chloroplast fraction, which demonstrated significant changes, major speciations were Pb sulfide (72%), basic Pb carbonate (16%), and Pb stearate (12%). Pb is blocked by cell walls as pyromorphite and Pb carbonate sediments and compartmentalized by vacuoles, which both play an inportant role in cell detoxification. Besides, sulfur-containing compounds form inside the cells.

AECAP Guide for State Leaders: State and Local Coordination and Planning to Strengthen Adult Basic Education Services

ERIC Educational Resources Information Center

Alamprese, Judith A.; Gwaltney, Margaret K.

2010-01-01

The Adult Education Coordination and Planning (AECAP) guide is designed to assist state adult education staff in forming partnerships at the state level and facilitating coordination at the local level as a lever for expanding and improving the quality of adult basic education (ABE) and workforce development services. Coordination plays a critical…

Processing of Basic Speech Acts Following Localized Brain Damage: A New Light on the Neuroanatomy of Language

ERIC Educational Resources Information Center

Soroker, N.; Kasher, A.; Giora, R.; Batori, G.; Corn, C.; Gil, M.; Zaidel, E.

2005-01-01

We examined the effect of localized brain lesions on processing of the basic speech acts (BSAs) of question, assertion, request, and command. Both left and right cerebral damage produced significant deficits relative to normal controls, and left brain damaged patients performed worse than patients with right-sided lesions. This finding argues…

The Role of Biomedical Librarians in a Local Basic Unit Library Organization.

ERIC Educational Resources Information Center

Taylor, Ruth

The quality of library service in biomedical institutions ultimately depends upon basic unit librarians. Although the hierarchy is necessary, it can only have as much real authority and cooperation as institutions vest in it by their degree of understanding and sense of personal worth. Vital to this is the local peer groups, which serves two basic…

Net current control device. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fugate, D.; Cooper, J.H.

1998-11-01

Net currents generally result in elevated magnetic fields because the alternate paths are distant from the circuit conductors. Investigations have shown that one of the primary sources of power frequency magnetic fields in residential buildings is currents that return to their source via paths other than the neutral conductors. As part of EPRI`s Magnetic Field Shielding Project, ferromagnetic devices, called net current control (NCC) devices, were developed and tested for use in reducing net currents on electric power cables and the resulting magnetic fields. Applied to a residential service drop, an NCC device reduces net current by forcing current offmore » local non-utility ground paths, and back onto the neutral conductor. Circuit models and basic design equations for the NCC concept were developed, and proof-of-principles tests were carried out on an actual residence with cooperation from the local utility. After proving the basic concepts, three prototype NCC devices were built and tested on a simulated neighborhood power system. Additional prototypes were built for testing by interested EPRI utility members. Results have shown that the NCC prototypes installed on residential service drops reduce net currents to milliampere levels with compromising the safety of the ground system. Although the focus was on application to residential service cables, the NCC concept is applicable to single-phase and three-phase distribution systems as well.« less

Theoretical proposal for a magnetic resonance study of charge transport in organic semiconductors

NASA Astrophysics Data System (ADS)

Mkhitaryan, Vagharsh

Charge transport in disordered organic semiconductors occurs via carrier incoherent hops in a band of localized states. In the framework of continuous-time random walk the carrier on-site waiting time distribution (WTD) is one of the basic characteristics of diffusion. Besides, WTD is fundamentally related to the density of states (DOS) of localized states, which is a key feature of a material determining the optoelectric properties. However, reliable first-principle calculations of DOS in organic materials are not yet available and experimental characterization of DOS and WTD is desirable. We theoretically study the spin dynamics of hopping carriers and propose measurement schemes directly probing WTD, based on the zero-field spin relaxation and the primary (Hahn) spin echo. The proposed schemes are possible because, as we demonstrate, the long-time behavior of the zero-field relaxation and the primary echo is determined by WTD, both for the hyperfine coupling dominated and the spin-orbit coupling dominated spin dynamics. We also examine the dispersive charge transport, which is a non-Markovian sub-diffusive process characterized by non-stationarity. We show that the proposed schemes unambiguously capture the effects of non-stationarity, e.g., the aging behavior of random walks. This work was supported by the Department of Energy-Basic Energy Sciences under Contract No. DE-AC02-07CH11358.

10 CFR 431.36 - Compliance Certification.

Code of Federal Regulations, 2014 CFR

2014-01-01

... EQUIPMENT Electric Motors Certification § 431.36 Compliance Certification. (a) General. A manufacturer or private labeler shall not distribute in commerce any basic model of an electric motor which is subject to... efficiency for each basic model of electric motor distributed is not less than the minimum nominal full load...

10 CFR 431.36 - Compliance Certification.

Code of Federal Regulations, 2013 CFR

2013-01-01

... EQUIPMENT Electric Motors Certification § 431.36 Compliance Certification. (a) General. A manufacturer or private labeler shall not distribute in commerce any basic model of an electric motor which is subject to... efficiency for each basic model of electric motor distributed is not less than the minimum nominal full load...

Physical Activity Basics

MedlinePlus

... Weight Breastfeeding Micronutrient Malnutrition State and Local Programs Physical Activity Basics Recommend on Facebook Tweet Share Compartir How much physical activity do you need? Regular physical activity helps improve ...

Probabilistic graphs as a conceptual and computational tool in hydrology and water management

NASA Astrophysics Data System (ADS)

Schoups, Gerrit

2014-05-01

Originally developed in the fields of machine learning and artificial intelligence, probabilistic graphs constitute a general framework for modeling complex systems in the presence of uncertainty. The framework consists of three components: 1. Representation of the model as a graph (or network), with nodes depicting random variables in the model (e.g. parameters, states, etc), which are joined together by factors. Factors are local probabilistic or deterministic relations between subsets of variables, which, when multiplied together, yield the joint distribution over all variables. 2. Consistent use of probability theory for quantifying uncertainty, relying on basic rules of probability for assimilating data into the model and expressing unknown variables as a function of observations (via the posterior distribution). 3. Efficient, distributed approximation of the posterior distribution using general-purpose algorithms that exploit model structure encoded in the graph. These attributes make probabilistic graphs potentially useful as a conceptual and computational tool in hydrology and water management (and beyond). Conceptually, they can provide a common framework for existing and new probabilistic modeling approaches (e.g. by drawing inspiration from other fields of application), while computationally they can make probabilistic inference feasible in larger hydrological models. The presentation explores, via examples, some of these benefits.

Wind tunnel tests for wind pressure distribution on gable roof buildings.

PubMed

Jing, Xiao-kun; Li, Yuan-qi

2013-01-01

Gable roof buildings are widely used in industrial buildings. Based on wind tunnel tests with rigid models, wind pressure distributions on gable roof buildings with different aspect ratios were measured simultaneously. Some characteristics of the measured wind pressure field on the surfaces of the models were analyzed, including mean wind pressure, fluctuating wind pressure, peak negative wind pressure, and characteristics of proper orthogonal decomposition results of the measured wind pressure field. The results show that extremely high local suctions often occur in the leading edges of longitudinal wall and windward roof, roof corner, and roof ridge which are the severe damaged locations under strong wind. The aspect ratio of building has a certain effect on the mean wind pressure coefficients, and the effect relates to wind attack angle. Compared with experimental results, the region division of roof corner and roof ridge from AIJ2004 is more reasonable than those from CECS102:2002 and MBMA2006.The contributions of the first several eigenvectors to the overall wind pressure distributions become much bigger. The investigation can offer some basic understanding for estimating wind load distribution on gable roof buildings and facilitate wind-resistant design of cladding components and their connections considering wind load path.

A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poulin, Patrick, E-mail: patrick-poulin@videotron.ca; Ekins, Sean; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, Baltimore, MD 21201

A general toxicity of basic drugs is related to phospholipidosis in tissues. Therefore, it is essential to predict the tissue distribution of basic drugs to facilitate an initial estimate of that toxicity. The objective of the present study was to further assess the original prediction method that consisted of using the binding to red blood cells measured in vitro for the unbound drug (RBCu) as a surrogate for tissue distribution, by correlating it to unbound tissue:plasma partition coefficients (Kpu) of several tissues, and finally to predict volume of distribution at steady-state (V{sub ss}) in humans under in vivo conditions. Thismore » correlation method demonstrated inaccurate predictions of V{sub ss} for particular basic drugs that did not follow the original correlation principle. Therefore, the novelty of this study is to provide clarity on the actual hypotheses to identify i) the impact of pharmacological mode of action on the generic correlation of RBCu-Kpu, ii) additional mechanisms of tissue distribution for the outlier drugs, iii) molecular features and properties that differentiate compounds as outliers in the original correlation analysis in order to facilitate its applicability domain alongside the properties already used so far, and finally iv) to present a novel and refined correlation method that is superior to what has been previously published for the prediction of human V{sub ss} of basic drugs. Applying a refined correlation method after identifying outliers would facilitate the prediction of more accurate distribution parameters as key inputs used in physiologically based pharmacokinetic (PBPK) and phospholipidosis models.« less

Comparison of theoretical proteomes: identification of COGs with conserved and variable pI within the multimodal pI distribution.

PubMed

Nandi, Soumyadeep; Mehra, Nipun; Lynn, Andrew M; Bhattacharya, Alok

2005-09-09

Theoretical proteome analysis, generated by plotting theoretical isoelectric points (pI) against molecular masses of all proteins encoded by the genome show a multimodal distribution for pI. This multimodal distribution is an effect of allowed combinations of the charged amino acids, and not due to evolutionary causes. The variation in this distribution can be correlated to the organisms ecological niche. Contributions to this variation maybe mapped to individual proteins by studying the variation in pI of orthologs across microorganism genomes. The distribution of ortholog pI values showed trimodal distributions for all prokaryotic genomes analyzed, similar to whole proteome plots. Pairwise analysis of pI variation show that a few COGs are conserved within, but most vary between, the acidic and basic regions of the distribution, while molecular mass is more highly conserved. At the level of functional grouping of orthologs, five groups vary significantly from the population of orthologs, which is attributed to either conservation at the level of sequences or a bias for either positively or negatively charged residues contributing to the function. Individual COGs conserved in both the acidic and basic regions of the trimodal distribution are identified, and orthologs that best represent the variation in levels of the acidic and basic regions are listed. The analysis of pI distribution by using orthologs provides a basis for resolution of theoretical proteome comparison at the level of individual proteins. Orthologs identified that significantly vary between the major acidic and basic regions maybe used as representative of the variation of the entire proteome.

GIS based spatial pattern analysis: Children with Hepatitis A in Turkey.

PubMed

Dogru, Ahmet Ozgur; David, Ruusa Magano; Ulugtekin, Necla; Goksel, Cigdem; Seker, Dursun Zafer; Sözen, Seval

2017-07-01

This study aimed to provide an insight into the geographic distribution of Hepatitis A incidence considering their temporal distribution, spatial patterns, hot spots and clusters identification in three different age-group (0-4, 5-9 and 10-14) in Turkey. Province based tabular data, including monthly numbers of Hepatitis A cases in children, and the populations from 2001 to 2011 were used as the basic input of the study. Time series maps were created using Geographic Information Systems (GIS) to introduce the temporal changes in the morbidity rates of Hepatitis A. The spatial variation of Hepatitis A was measured using Moran's I at the global level and the local indicators of spatial associations (LISAs) Moran's I and Getis-Ord G i *(d) in order to identify influential locations through clusters and hot spots detection of Hepatitis A cases. The morbidity rates in children under the age of 5 were found significantly lower than the other age-groups, whereas the age-group 5-9 revealed the highest morbidity rates in the study area. The morbidity of Hepatitis A was detected very high for the years 2001, and 2005-2007. The identification of the highly vulnerable provinces was conducted using local Moran's I and local Getis-Ord G i *(d). The majority of clusters and hot spots were detected to be agglomerated in the Eastern Mediterranean and South-Eastern Anatolian Regions and Ceyhan, Asi and Southeast part of Firat-Dicle river basins in Turkey. Copyright © 2017 Elsevier Inc. All rights reserved.

Omega flight-test data reduction sequence. [computer programs for reduction of navigation data

NASA Technical Reports Server (NTRS)

Lilley, R. W.

1974-01-01

Computer programs for Omega data conversion, summary, and preparation for distribution are presented. Program logic and sample data formats are included, along with operational instructions for each program. Flight data (or data collected in flight format in the laboratory) is provided by the Ohio University Omega receiver base in the form of 6-bit binary words representing the phase of an Omega station with respect to the receiver's local clock. All eight Omega stations are measured in each 10-second Omega time frame. In addition, an event-marker bit and a time-slot D synchronizing bit are recorded. Program FDCON is used to remove data from the flight recorder tape and place it on data-processing cards for later use. Program FDSUM provides for computer plotting of selected LOP's, for single-station phase plots, and for printout of basic signal statistics for each Omega channel. Mean phase and standard deviation are printed, along with data from which a phase distribution can be plotted for each Omega station. Program DACOP simply copies the Omega data deck a controlled number of times, for distribution to users.

Get Involved in the Job Opportunities and Basic Skills Training Program (JOBS). What Local Areas Need To Know.

ERIC Educational Resources Information Center

JTPA Issues, 1989

1989-01-01

This Job Training Partnership Act (JTPA) Update provides a quick primer of some of the key areas where states have flexibility to develop their own programs and processes in the new Job Opportunities and Basic Skills (JOBS) program. This guide is organized in seven sections that cover the following topics: (1) introduction; (2) why local areas…

Virginia State Adult Basic Education Administrative Guide for Local Programs and Projects under the Adult Education Act, P.L. 91-230 and Amendments.

ERIC Educational Resources Information Center

Virginia State Dept. of Education, Richmond. Adult Education Service.

This administrative guide was developed to provide local school divisions and other agencies operating federally funded Adult Basic Education (ABE) programs in Virginia with the purpose, requirements, and procedures for conducting these programs. The guide is divided into eleven sections. The introduction covers the purpose and scope of ABE…

Phosphoinositide-binding proteins in autophagy.

PubMed

Lystad, Alf Håkon; Simonsen, Anne

2016-08-01

Phosphoinositides represent a very small fraction of membrane phospholipids, having fast turnover rates and unique subcellular distributions, which make them perfect for initiating local temporal effects. Seven different phosphoinositide species are generated through reversible phosphorylation of the inositol ring of phosphatidylinositol (PtdIns). The negative charge generated by the phosphates provides specificity for interaction with various protein domains that commonly contain a cluster of basic residues. Examples of domains that bind phosphoinositides include PH domains, WD40 repeats, PX domains, and FYVE domains. Such domains often display specificity toward a certain species or subset of phosphoinositides. Here we will review the current literature of different phosphoinositide-binding proteins involved in autophagy. © 2016 Federation of European Biochemical Societies.

Waterworks Operator Training Manual.

ERIC Educational Resources Information Center

Missouri Univ., Columbia. Instructional Materials Lab.

Sixteen self-study waterworks operators training modules are provided. Module titles are the following: basic mathematics, basic chemistry, analysis procedures, microbiology, basic electricity, hydraulics, chlorination, plant operation, surface water, ground water, pumps, cross connections, distribution systems, safety, public relations, and…

The relationship between built-up areas and the spatial development of the mean maximum urban heat island in Debrecen, Hungary

NASA Astrophysics Data System (ADS)

Bottyán, Zsolt; Kircsi, Andrea; Szegedi, Sándor; Unger, János

2005-03-01

The climate of built-up regions differs significantly from rural regions and the most important modifying effect of urbanization on local climate is the urban temperature excess, otherwise called the urban heat island (UHI).This study examines the influence of built-up areas on the near-surface air temperature field in the case of the medium-sized city of Debrecen, Hungary. Mobile measurements were used under different weather conditions between March 2002 and March 2003. Efforts concentrated on the determination of the spatial distribution of mean maximum UHI intensity with special regard to land-use features such as built-up ratio and its areal extensions.In both (heating and non-heating) seasons the spatial distribution of the UHI intensity field showed a basically concentric shape with local anomalies. The mean maximum UHI intensity reaches more than 2.0 °C (heating season) and 2.5 °C (non-heating season) in the centre of the city. We established the relationship between the above-mentioned land-use parameters and mean maximum UHI intensity by means of multiple linear regression analysis. As the measured and predicted mean maximum UHI intensity patterns show, there is an obvious connection between the spatial distribution of urban thermal excess and the land-use parameters examined, so these parameters play a significant role in the development of the strong UHI intensity field over the city.

10 CFR 429.70 - Alternative methods for determining energy efficiency or energy use.

Code of Federal Regulations, 2013 CFR

2013-01-01

... of commercial HVAC and WH equipment, distribution transformers, and central air conditioners and heat... overrate the efficiency of a basic model. For each basic model of distribution transformer that has a... voltage at which the transformer is rated to operate. (b) Testing. Testing for each covered product or...

Coherent Structures and Evolution of Vorticity in Short-Crested Breaking Surface Waves

NASA Astrophysics Data System (ADS)

Kirby, James; Derakhti, Morteza

2017-11-01

We employ a multi-phase LES/VOF code to study turbulence and coherent structures generated during breaking of short-crested surface water waves. We examine the evolution of coherent vortex structures evolving at the scale of the width of the breaking event, and their long-time interaction with smaller vortex loops formed by the local instability of the breaking crest. Long-time results are often characterized by the detachment of the larger scale vortex loop from the surface and formation of a closed vortex ring. The evolution of circulation for the vortical flow field is examined. The initial concentration of forcing close to the free surface leads to spatial distributions of both span-wise and vertical vorticity distributions which are concentrated close to the surface. This result, which persists into shallow water, is at odds with the basic simplicity of the Peregrine mechanism, suggesting that even shallow flows such as the surf zone should be regarded as being forced (in dissipative situations) by a wave-induced surface stress rather than a uniform-over-depth body force. The localized forcing leads to the development of a complex pattern of stream-wise vorticity, comparable in strength to the vertical and span-wise components, and also persist into shallow water. NSF OCE-1435147.

Time domain structures in a colliding magnetic flux rope experiment

NASA Astrophysics Data System (ADS)

Tang, Shawn Wenjie; Gekelman, Walter; Dehaas, Timothy; Vincena, Steve; Pribyl, Patrick

2017-10-01

Electron phase-space holes, regions of positive potential on the scale of the Debye length, have been observed in auroras as well as in laboratory experiments. These potential structures, also known as Time Domain Structures (TDS), are packets of intense electric field spikes that have significant components parallel to the local magnetic field. In an ongoing investigation at UCLA, TDS were observed on the surface of two magnetized flux ropes produced within the Large Plasma Device (LAPD). A barium oxide (BaO) cathode was used to produce an 18 m long magnetized plasma column and a lanthanum hexaboride (LaB6) source was used to create 11 m long kink unstable flux ropes. Using two probes capable of measuring the local electric and magnetic fields, correlation analysis was performed on tens of thousands of these structures and their propagation velocities, probability distribution function and spatial distribution were determined. The TDS became abundant as the flux ropes collided and appear to emanate from the reconnection region in between them. In addition, a preliminary analysis of the permutation entropy and statistical complexity of the data suggests that the TDS signals may be chaotic in nature. Work done at the Basic Plasma Science Facility (BaPSF) at UCLA which is supported by DOE and NSF.

Before Mina Shaughnessy: Basic Writing at Yale, 1920-1960

ERIC Educational Resources Information Center

Ritter, Kelly

2008-01-01

This article examines Yale's "Awkward Squad" of "basic" writers between 1920 and 1960. Using archival materials that illustrate the socioeconomic conditions of this early, "pre-Shaughnessy" site of remedial writing instruction, I argue for a re-definition of "basic" in composition studies using local, institutional values rather than generic…

7 CFR 1463.105 - Base quota levels for eligible quota holders.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the BQL adjustment factor 1.071295. (Note: The factor adjusts the 2004 basic quota to the 2002 basic... farm. (Note: In the case of undivided tract ownership, BQL must be distributed among the tract quota... basic quota, multiplied by the BQL adjustment factor 1.23457. (Note: The factor adjusts the 2004 basic...

7 CFR 1463.105 - Base quota levels for eligible quota holders.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the BQL adjustment factor 1.071295. (Note: The factor adjusts the 2004 basic quota to the 2002 basic... farm. (Note: In the case of undivided tract ownership, BQL must be distributed among the tract quota... basic quota, multiplied by the BQL adjustment factor 1.23457. (Note: The factor adjusts the 2004 basic...

Classic Nuclear Localization Signals and a Novel Nuclear Localization Motif Are Required for Nuclear Transport of Porcine Parvovirus Capsid Proteins

PubMed Central

Boisvert, Maude; Bouchard-Lévesque, Véronique; Fernandes, Sandra

2014-01-01

ABSTRACT Nuclear targeting of capsid proteins (VPs) is important for genome delivery and precedes assembly in the replication cycle of porcine parvovirus (PPV). Clusters of basic amino acids, corresponding to potential nuclear localization signals (NLS), were found only in the unique region of VP1 (VP1up, for VP1 unique part). Of the five identified basic regions (BR), three were important for nuclear localization of VP1up: BR1 was a classic Pat7 NLS, and the combination of BR4 and BR5 was a classic bipartite NLS. These NLS were essential for viral replication. VP2, the major capsid protein, lacked these NLS and contained no region with more than two basic amino acids in proximity. However, three regions of basic clusters were identified in the folded protein, assembled into a trimeric structure. Mutagenesis experiments showed that only one of these three regions was involved in VP2 transport to the nucleus. This structural NLS, termed the nuclear localization motif (NLM), is located inside the assembled capsid and thus can be used to transport trimers to the nucleus in late steps of infection but not for virions in initial infection steps. The two NLS of VP1up are located in the N-terminal part of the protein, externalized from the capsid during endosomal transit, exposing them for nuclear targeting during early steps of infection. Globally, the determinants of nuclear transport of structural proteins of PPV were different from those of closely related parvoviruses. IMPORTANCE Most DNA viruses use the nucleus for their replication cycle. Thus, structural proteins need to be targeted to this cellular compartment at two distinct steps of the infection: in early steps to deliver viral genomes to the nucleus and in late steps to assemble new viruses. Nuclear targeting of proteins depends on the recognition of a stretch of basic amino acids by cellular transport proteins. This study reports the identification of two classic nuclear localization signals in the minor capsid protein (VP1) of porcine parvovirus. The major protein (VP2) nuclear localization was shown to depend on a complex structural motif. This motif can be used as a strategy by the virus to avoid transport of incorrectly folded proteins and to selectively import assembled trimers into the nucleus. Structural nuclear localization motifs can also be important for nuclear proteins without a classic basic amino acid stretch, including multimeric cellular proteins. PMID:25078698

Analysis of a developmentally regulated nuclear localization signal in Xenopus

PubMed Central

1992-01-01

The 289 residue nuclear oncoprotein encoded by the adenovirus 5 Ela gene contains two peptide sequences that behave as nuclear localization signals (NLS). One signal, located at the carboxy terminus, is like many other known NLSs in that it consists of a short stretch of basic residues (KRPRP) and is constitutively active in cells. The second signal resides within an internal 45 residue region of E1a that contains few basic residues or sequences that resemble other known NLSs. Moreover, this internal signal functions in injected Xenopus oocytes, but not in transfected Xenopus A6 cells, suggesting that it could be regulated developmentally (Slavicek et al. 1989. J. Virol. 63:4047). In this study, we show that the activity of this signal is sensitive to ATP depletion in vivo, efficiently directs the import of a 50 kD fusion protein and can compete with the E1a carboxy-terminal NLS for nuclear import. In addition, we have delineated the precise amino acid residues that comprise the second E1a NLS, and have assessed its utilization during Xenopus embryogenesis. Using amino acid deletion and substitution analyses, we show that the signal consists of the sequence FV(X)7-20MXSLXYM(X)4MF. By expressing in Xenopus embryos a truncated E1a protein that contains only the second NLS and by monitoring its cytoplasmic/nuclear distribution during development with indirect immunofluorescence, we find that the second NLS is utilized up to the early neurula stage. In addition, there appears to be a hierarchy among the embryonic germ layers as to when the second NLS becomes nonfunctional. For this reason, we refer to this NLS as the developmentally regulated nuclear localization signal (drNLS). The implications of these findings for early development are discussed. PMID:1387407

Comparison of theoretical proteomes: Identification of COGs with conserved and variable pI within the multimodal pI distribution

PubMed Central

Nandi, Soumyadeep; Mehra, Nipun; Lynn, Andrew M; Bhattacharya, Alok

2005-01-01

Background Theoretical proteome analysis, generated by plotting theoretical isoelectric points (pI) against molecular masses of all proteins encoded by the genome show a multimodal distribution for pI. This multimodal distribution is an effect of allowed combinations of the charged amino acids, and not due to evolutionary causes. The variation in this distribution can be correlated to the organisms ecological niche. Contributions to this variation maybe mapped to individual proteins by studying the variation in pI of orthologs across microorganism genomes. Results The distribution of ortholog pI values showed trimodal distributions for all prokaryotic genomes analyzed, similar to whole proteome plots. Pairwise analysis of pI variation show that a few COGs are conserved within, but most vary between, the acidic and basic regions of the distribution, while molecular mass is more highly conserved. At the level of functional grouping of orthologs, five groups vary significantly from the population of orthologs, which is attributed to either conservation at the level of sequences or a bias for either positively or negatively charged residues contributing to the function. Individual COGs conserved in both the acidic and basic regions of the trimodal distribution are identified, and orthologs that best represent the variation in levels of the acidic and basic regions are listed. Conclusion The analysis of pI distribution by using orthologs provides a basis for resolution of theoretical proteome comparison at the level of individual proteins. Orthologs identified that significantly vary between the major acidic and basic regions maybe used as representative of the variation of the entire proteome. PMID:16150155

Tendency to occupy a statistically dominant spatial state of the flow as a driving force for turbulent transition.

PubMed

Chekmarev, Sergei F

2013-03-01

The transition from laminar to turbulent fluid motion occurring at large Reynolds numbers is generally associated with the instability of the laminar flow. On the other hand, since the turbulent flow characteristically appears in the form of spatially localized structures (e.g., eddies) filling the flow field, a tendency to occupy such a structured state of the flow cannot be ruled out as a driving force for turbulent transition. To examine this possibility, we propose a simple analytical model that treats the flow as a collection of localized spatial structures, each of which consists of elementary cells in which the behavior of the particles (atoms or molecules) is uncorrelated. This allows us to introduce the Reynolds number, associating it with the ratio between the total phase volume for the system and that for the elementary cell. Using the principle of maximum entropy to calculate the most probable size distribution of the localized structures, we show that as the Reynolds number increases, the elementary cells group into the localized structures, which successfully explains turbulent transition and some other general properties of turbulent flows. An important feature of the present model is that a bridge between the spatial-statistical description of the flow and hydrodynamic equations is established. We show that the basic assumptions underlying the model, i.e., that the particles are indistinguishable and elementary volumes of phase space exist in which the state of the particles is uncertain, are involved in the derivation of the Navier-Stokes equation. Taking into account that the model captures essential features of turbulent flows, this suggests that the driving force for the turbulent transition is basically the same as in the present model, i.e., the tendency of the system to occupy a statistically dominant state plays a key role. The instability of the flow at high Reynolds numbers can then be a mechanism to initiate structural rearrangement of the flow to find this state.

Risky business: perceived behavior of local scientists and community support for their research.

PubMed

McComas, Katherine A; Besley, John C; Yang, Zheng

2008-12-01

Attracting new technologies to a region can mean significant economic growth, so understanding why some communities may not favor becoming "the next Silicon Valley" merits consideration. This study investigates the relationship among the perceived behavior of local scientists and community members' attitudes toward their research. Drawing on theories from organizational justice, it hypothesizes that when local residents consider scientists as more just in their behavior, they will also have more favorable attitudes toward the scientists and their research. Just, in this sense, refers to whether scientists are perceived as fair in terms of outcomes, procedures, interpersonal treatment, and explanations in their dealings with the community. Favorable attitudes are measured in terms of concern about new technologies and satisfaction with research. Data were collected via a mail survey of residents in two upstate New York counties (N= 1,306) that host substantial technology research facilities. Controlling for demographics, media use, basic science knowledge, and technology awareness, the results show that distributive justice (i.e., fairness of outcomes) had a consistent, negative relationship with technology concern. In comparison, all four justice variables were positively related with research satisfaction. The findings suggest that the perceived behavior of local scientists may indeed impact community support for their research.

Analysis of Influenza and RSV dynamics in the community using a ‘Local Transmission Zone’ approach

NASA Astrophysics Data System (ADS)

Almogy, Gal; Stone, Lewi; Bernevig, B. Andrei; Wolf, Dana G.; Dorozko, Marina; Moses, Allon E.; Nir-Paz, Ran

2017-02-01

Understanding the dynamics of pathogen spread within urban areas is critical for the effective prevention and containment of communicable diseases. At these relatively small geographic scales, short-distance interactions and tightly knit sub-networks dominate the dynamics of pathogen transmission; yet, the effective boundaries of these micro-scale groups are generally not known and often ignored. Using clinical test results from hospital admitted patients we analyze the spatio-temporal distribution of Influenza Like Illness (ILI) in the city of Jerusalem over a period of three winter seasons. We demonstrate that this urban area is not a single, perfectly mixed ecology, but is in fact comprised of a set of more basic, relatively independent pathogen transmission units, which we term here Local Transmission Zones, LTZs. By identifying these LTZs, and using the dynamic pathogen-content information contained within them, we are able to differentiate between disease-causes at the individual patient level often with near-perfect predictive accuracy.

Thermal inclusions: how one spin can destroy a many-body localized phase

NASA Astrophysics Data System (ADS)

Ponte, Pedro; Laumann, C. R.; Huse, David A.; Chandran, A.

2017-10-01

Many-body localized (MBL) systems lie outside the framework of statistical mechanics, as they fail to equilibrate under their own quantum dynamics. Even basic features of MBL systems, such as their stability to thermal inclusions and the nature of the dynamical transition to thermalizing behaviour, remain poorly understood. We study a simple central spin model to address these questions: a two-level system interacting with strength J with N≫1 localized bits subject to random fields. On increasing J, the system transitions from an MBL to a delocalized phase on the vanishing scale Jc(N)˜1/N, up to logarithmic corrections. In the transition region, the single-site eigenstate entanglement entropies exhibit bimodal distributions, so that localized bits are either `on' (strongly entangled) or `off' (weakly entangled) in eigenstates. The clusters of `on' bits vary significantly between eigenstates of the same sample, which provides evidence for a heterogeneous discontinuous transition out of the localized phase in single-site observables. We obtain these results by perturbative mapping to bond percolation on the hypercube at small J and by numerical exact diagonalization of the full many-body system. Our results support the arguments that the MBL phase is unstable in systems with short-range interactions and quenched randomness in dimensions d that are high but finite. This article is part of the themed issue 'Breakdown of ergodicity in quantum systems: from solids to synthetic matter'.

Star Formation Histories of Local Group Dwarf Galaxies. (Ludwig Biermann Award Lecture 1996)

NASA Astrophysics Data System (ADS)

Grebel, E. K.

The star formation histories of dwarf galaxies in the Local Group are reviewed. First the question of Local Group membership is considered based on various criteria. The properties of 31 (36) galaxies are consistent with likely (potential) Local Group membership. To study the star formation histories of these galaxies, a multi-parameter problem needs to be solved: Ages, metallicities, population fractions, and spatial variations must be determined, which depend crucially on the knowledge of reddening and distance. The basic methods for studying resolvable stellar populations are summarized. One method is demonstrated using the Fornax dwarf spheroidal galaxy. A comprehensive compilation of the star formation histories of dwarf irregulars, dwarf ellipticals, and dwarf spheroidals in the Local Group is presented and visualized through Hodge's population boxes. All galaxies appear to have differing fractions of old and intermediate-age populations, and those sufficiently massive and undisturbed to retain and recycle their gas are still forming stars today. Star formation has occurred either in distinct episodes or continuously over long periods of time. Metallicities and enrichment vary widely. Constraints on merger and remnant scenarios are discussed, and a unified picture based on the current knowledge is presented. Primary goals for future observations are: accurate age determinations based on turnoff photometry, detection of subpopulations distinct in age, metallicity, and/or spatial distribution; improved distances; and astrometric studies to derive orbits and constrain past and future interactions.

HIV-1 nucleocapsid protein localizes efficiently to the nucleus and nucleolus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Kyung Lee; Lee, Sun Hee; Lee, Eun Soo

The HIV-1 nucleocapsid (NC) is an essential viral protein containing two highly conserved retroviral-type zinc finger (ZF) motifs, which functions in multiple stages of the HIV-1 life cycle. Although a number of functions for NC either in its mature form or as a domain of Gag have been revealed, little is known about the intracellular localization of NC and, moreover, its role in Gag protein trafficking. Here, we have investigated various forms of HIV-1 NC protein for its cellular localization and found that the NC has a strong nuclear and nucleolar localization activity. The linker region, composed of a stretchmore » of basic amino acids between the two ZF motifs, was necessary and sufficient for the activity. - Highlights: • HIV-1 NC possess a NLS and leads to nuclear and nucleolus localization. • Mutations in basic residues between two ZFs in NC decrease the nucleus localization. • ZFs of NC affect cytoplasmic organelles localization rather than nucleus localization.« less

The evolution of the federal funding policies for the public health surveillance component of Brazil's Unified Health System (SUS).

PubMed

Pinto, Vitor Laerte; Cerbino Neto, José; Penna, Gerson Oliveira

2014-12-01

Health surveillance (HS) is one of the key components of the Brazilian Unified Health System (SUS). This article describes recent changes in health surveillance funding models and the role these changes have had in the reorganization and decentralization of health actions. Federal law no. 8.080 of 1990 defined health surveillance as a fundamental pillar of the SUS, and an exclusive fund with equitable distribution criteria was created in the Basic Operational Norm of 1996 to pay for health surveillance actions. This step facilitated the decentralization of health care at the municipal level, giving local authorities autonomy to plan and provide services. The Health Pact of 2006 and its regulation under federal decree No. 3252 in 2009 bolstered the processes of decentralization, regionalization and integration of health care. Further changes in the basic concepts of health surveillance around the world and in the funding policies negotiated by different spheres of government in Brazil have been catalysts for the process of HS institutionalization in recent years.

Basic data for some recent Australian heat-flow measurements

USGS Publications Warehouse

Munroe, Robert J.; Sass, J.H.; Milburn, G.T.; Jaeger, J.C.; Tammemagi, H.Y.

1975-01-01

This report has been compiled to provide background information and detailed temperature and thermal conductivity data for the heat-flow values reported in Sass, Jaeger, and Munroe (in press). The data were collected as part of a joint heat-flow study by the Australian National University (ANU) and the U.S. Geological Survey (USGS) under the direction of J. C. Jaeger (ANU) and J. H. Sass (USGS). The format is similar to that used for basic data from United States heat-flow determinations (Sass and Munroe, 1974). Each section contains a state map showing the geographic distribution of heat-flow data followed by tables which list individual temperatures, thermal conductivities, and radiogenic heat production values. A companion volume (Bunker and others, 1975) gives details of the heat-production measurements together with individual radioelement concentrations. Localities are arranged in alphabetical order within each state. The methods and techniques of measurements have been described by Sass and others (1971a, b). Unusual methods or procedures which differ markedly from these techniques are noted and described in the comments sections of the tables.

Private Sector Providers of Basic Skills Training in the Workplace. A Study of the General Training and Basic Skills Responses of Randomly Selected Companies Which Provide Basic Skills Training to Their Employees.

ERIC Educational Resources Information Center

Mark, Jorie Lester

A questionnaire was distributed to 1,305 companies to study the basic skills training provided. Of 62 responses, 41 companies had basic skills training programs. Respondents represented these types of companies: communications and utilities, finance and insurance, manufacturing, wholesalers, retailers, health and hospitals, and mining, and had…

Music Tune Restoration Based on a Mother Wavelet Construction

NASA Astrophysics Data System (ADS)

Fadeev, A. S.; Konovalov, V. I.; Butakova, T. I.; Sobetsky, A. V.

2017-01-01

It is offered to use the mother wavelet function obtained from the local part of an analyzed music signal. Requirements for the constructed function are proposed and the implementation technique and its properties are described. The suggested approach allows construction of mother wavelet families with specified identifying properties. Consequently, this makes possible to identify the basic signal variations of complex music signals including local time-frequency characteristics of the basic one.

Predicting presence and absence of trout (Salmo trutta) in Iran

PubMed Central

Mostafavi, Hossein; Pletterbauer, Florian; Coad, Brian W.; Mahini, Abdolrassoul Salman; Schinegger, Rafaela; Unfer, Günther; Trautwein, Clemens; Schmutz, Stefan

2014-01-01

Species distribution modelling, as a central issue in freshwater ecology, is an important tool for conservation and management of aquatic ecosystems. The brown trout (Salmo trutta) is a sensitive species which reacts to habitat changes induced by human impacts. Therefore, the identification of suitable habitats is essential. This study explores the potential distribution of brown trout by a species distribution modelling approach for Iran. Furthermore, modelling results are compared to the distribution described in the literature. Areas outside the currently known distribution which may offer potential habitats for brown trout are identified. The species distribution modelling was based on five different modelling techniques: Generalised Linear Model, Generalised Additive Model, Generalised Boosting Model, Classification Tree Analysis and Random Forests, which are finally summarised in an ensemble forecasting approach. We considered four environmental descriptors at the local scale (slope, bankfull width, wetted width, and elevation) and three climatic parameters (mean air temperature, range of air temperature and annual precipitation) which were extracted on three different spatial extents (1/5/10 km). The performance of all models was excellent (≥0.8) according to the TSS (True Skill Statistic) criterion. Slope, mean and range of air temperature were the most important variables in predicting brown trout occurrence. Presented results deepen the knowledge about distribution patterns of brown trout in Iran. Moreover, this study gives a basic background for the future development of assessment methods for riverine ecosystems in Iran. PMID:24707064

Motion of gas in highly rarefied space

NASA Astrophysics Data System (ADS)

Chirkunov, Yu A.

2017-10-01

A model describing a motion of gas in a highly rarefied space received an unlucky number 13 in the list of the basic models of the motion of gas in the three-dimensional space obtained by L.V. Ovsyannikov. For a given initial pressure distribution, a special choice of mass Lagrangian variables leads to the system describing this motion for which the number of independent variables is less by one. Hence, there is a foliation of a highly rarefied gas with respect to pressure. In a strongly rarefied space for each given initial pressure distribution, all gas particles are localized on a two-dimensional surface that moves with time in this space We found some exact solutions of the obtained system that describe the processes taking place inside of the tornado. For this system we found all nontrivial conservation laws of the first order. In addition to the classical conservation laws the system has another conservation law, which generalizes the energy conservation law. With the additional condition we found another one generalized energy conservation law.

Mutiny over Bounty?

PubMed

Hutchison, T; Rolles, C J

1984-06-09

Bounty Services Ltd advertise commercial products on postnatal wards of hospitals throughout Britain by means of free gifts. Since the " Bounty lady" is apparently well known to nursing staff but may have gone unnoticed by paediatricians and obstetricians an investigation was conducted of the quality of the gifts and the nature of the company. With two exceptions the samples and promotional leaflets were sound, and mothers apparently enjoyed receiving them. Educational pamphlets distributed with the gifts were excellent, and cine films shown to the mothers were of good quality and informative about basic parental skills. Bounty , however, operates by exerting commercial pressure on new mothers at a time when they are most vulnerable and distributes materials among them without consultation with medical staff. Most of the mothers questioned assumed that the service was being provided by the NHS. The Bounty service may or may not be perceived as a satisfactory operation but details should be known to paediatricians and obstetricians; any action to be taken might be decided locally after discussion in individual hospitals or districts.

General advancing front packing algorithm for the discrete element method

NASA Astrophysics Data System (ADS)

Morfa, Carlos A. Recarey; Pérez Morales, Irvin Pablo; de Farias, Márcio Muniz; de Navarra, Eugenio Oñate Ibañez; Valera, Roberto Roselló; Casañas, Harold Díaz-Guzmán

2018-01-01

A generic formulation of a new method for packing particles is presented. It is based on a constructive advancing front method, and uses Monte Carlo techniques for the generation of particle dimensions. The method can be used to obtain virtual dense packings of particles with several geometrical shapes. It employs continuous, discrete, and empirical statistical distributions in order to generate the dimensions of particles. The packing algorithm is very flexible and allows alternatives for: 1—the direction of the advancing front (inwards or outwards), 2—the selection of the local advancing front, 3—the method for placing a mobile particle in contact with others, and 4—the overlap checks. The algorithm also allows obtaining highly porous media when it is slightly modified. The use of the algorithm to generate real particle packings from grain size distribution curves, in order to carry out engineering applications, is illustrated. Finally, basic applications of the algorithm, which prove its effectiveness in the generation of a large number of particles, are carried out.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knudsen, J.K.; Smith, C.L.

The steps involved to incorporate parameter uncertainty into the Nuclear Regulatory Commission (NRC) accident sequence precursor (ASP) models is covered in this paper. Three different uncertainty distributions (i.e., lognormal, beta, gamma) were evaluated to Determine the most appropriate distribution. From the evaluation, it was Determined that the lognormal distribution will be used for the ASP models uncertainty parameters. Selection of the uncertainty parameters for the basic events is also discussed. This paper covers the process of determining uncertainty parameters for the supercomponent basic events (i.e., basic events that are comprised of more than one component which can have more thanmore » one failure mode) that are utilized in the ASP models. Once this is completed, the ASP model is ready to be utilized to propagate parameter uncertainty for event assessments.« less

In vivo subcellular localization of Mal de Rio Cuarto virus (MRCV) non-structural proteins in insect cells reveals their putative functions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maroniche, Guillermo A.; Mongelli, Vanesa C.; Llauger, Gabriela

2012-09-01

The in vivo subcellular localization of Mal de Rio Cuarto virus (MRCV, Fijivirus, Reoviridae) non-structural proteins fused to GFP was analyzed by confocal microscopy. P5-1 showed a cytoplasmic vesicular-like distribution that was lost upon deleting its PDZ binding TKF motif, suggesting that P5-1 interacts with cellular PDZ proteins. P5-2 located at the nucleus and its nuclear import was affected by the deletion of its basic C-termini. P7-1 and P7-2 also entered the nucleus and therefore, along with P5-2, could function as regulators of host gene expression. P6 located in the cytoplasm and in perinuclear cloud-like inclusions, was driven to P9-1more » viroplasm-like structures and co-localized with P7-2, P10 and {alpha}-tubulin, suggesting its involvement in viroplasm formation and viral intracellular movement. Finally, P9-2 was N-glycosylated and located at the plasma membrane in association with filopodia-like protrusions containing actin, suggesting a possible role in virus cell-to-cell movement and spread.« less

Local interaction simulation approach to modelling nonclassical, nonlinear elastic behavior in solids.

PubMed

Scalerandi, Marco; Agostini, Valentina; Delsanto, Pier Paolo; Van Den Abeele, Koen; Johnson, Paul A

2003-06-01

Recent studies show that a broad category of materials share "nonclassical" nonlinear elastic behavior much different from "classical" (Landau-type) nonlinearity. Manifestations of "nonclassical" nonlinearity include stress-strain hysteresis and discrete memory in quasistatic experiments, and specific dependencies of the harmonic amplitudes with respect to the drive amplitude in dynamic wave experiments, which are remarkably different from those predicted by the classical theory. These materials have in common soft "bond" elements, where the elastic nonlinearity originates, contained in hard matter (e.g., a rock sample). The bond system normally comprises a small fraction of the total material volume, and can be localized (e.g., a crack in a solid) or distributed, as in a rock. In this paper a model is presented in which the soft elements are treated as hysteretic or reversible elastic units connected in a one-dimensional lattice to elastic elements (grains), which make up the hard matrix. Calculations are performed in the framework of the local interaction simulation approach (LISA). Experimental observations are well predicted by the model, which is now ready both for basic investigations about the physical origins of nonlinear elasticity and for applications to material damage diagnostics.

Teachers' Involvement in Implementing the Basic Science and Technology Curriculum of the Nine-Year Basic Education

ERIC Educational Resources Information Center

Odili, John Nwanibeze; Ebisine, Sele Sylvester; Ajuar, Helen Nwakaife

2011-01-01

The study investigated teachers' involvement in implementing the basic science and technology curriculum in primary schools in WSLGA (Warri South Local Government Area) of Delta State. It sought to identify the availability of the document in primary schools and teachers' knowledge of the objectives and activities specified in the curriculum.…

Water resources data for New Mexico, water year 1967; Part 1. surface water records

USGS Publications Warehouse

,

1968-01-01

an area whose boundaries coincided with those of certain natural drainage areas. The records in New Mexico were contained in Parts 7, 8, and 9 of that series. Beginning with the 1961 water year, streamflow records and related data have been released by the Geological Survey in annual reports on a State-boundary basis. Distribution of these basic-data reports is limited and primarily for local needs. The records will be published in Geological Survey water-supply papers at 5-year intervals. These 5-year water-supply papers will show daily discharge and will be compiled on the same geographical areas previously used for the annual series; however, some of the 14 parts of conterminous United States will be further subdivided.

Initial commented checklist of Iranian mayflies, with new area records and description of Procloeon caspicum sp. n. (Insecta, Ephemeroptera, Baetidae)

PubMed Central

Bojková, Jindřiška; Sroka, Pavel; Soldán, Tomáš; Namin, Javid Imanpour; Staniczek, Arnold H.; Polášek, Marek; Hrivniak, Ľuboš; Abdoli, Ashgar; Godunko, Roman J.

2018-01-01

Abstract An initial checklist of mayflies (Ephemeroptera) of Iran is compiled based on critical review of available literature data, complemented with new data from 38 localities of Gilan and Ardabil provinces. At present, altogether only 46 species and 25 genera are known from Iran, 18 species are reported as new to Iran in this study. Some previously published data are critically evaluated and doubtful taxa are excluded from the list. Basic analysis of the distribution and biogeography of recorded species is given. Procloeon (Pseudocentroptilum) caspicum Sroka, sp. n. is described based on mature larva and egg. Critical differential diagnostic characters distinguishing the species from related taxa are discussed in detail. PMID:29674922

The feasibility of desorption on Zeolite-water pair using dry gas

NASA Astrophysics Data System (ADS)

Oktariani, E.; Nakashima, K.; Noda, A.; Xue, B.; Tahara, K.; Nakaso, K.; Fukai, J.

2018-04-01

The increase in temperature, reduction in partial pressure, reduction in concentration, purging with an inert fluid, and displacement with a more strongly adsorbing species are the basic things that occur in the practical method of desorption. In this study, dry gas at constant temperature and pressure was employed as the aid to reduce the partial pressure in the water desorption on the zeolite 13X. The objective of this study is to confirm the feasibility of desorption using dry gas experimentally and numerically. The implication of heat and mass transfers were numerically investigated to find the most influential. The results of numerical simulation agree with the experimental ones for the distribution of local temperature and average water adsorbed in the packed bed.

“... And Gladly Teach”: The American Hospital Association's Experience in Conducting Institutes on Hospital Librarianship

PubMed Central

Yast, Helen

1964-01-01

As part of its overall educational program, the American Hospital Association has since 1959 conducted three institutes on hospital librarianship to meet the demand for more competent librarians in medical, nursing school, and patients' libraries. The purpose of such institutes is to teach the basic elements of library science to untrained personnel in hospital libraries. Discussed are steps in initiating an institute; factors determining length, date, and place; financing; publicity; choice and responsibility of local advisory committee; program content; qualifications of instructors; characteristics of registrants; materials for distribution; evaluations. Details of the most recent institute are outlined. A summary of problems still facing this type of educational program and suggestions for future improvements conclude the paper. PMID:14119309

Dexmedetomidine Disrupts the Local and Global Efficiencies of Large-scale Brain Networks.

PubMed

Hashmi, Javeria A; Loggia, Marco L; Khan, Sheraz; Gao, Lei; Kim, Jieun; Napadow, Vitaly; Brown, Emery N; Akeju, Oluwaseun

2017-03-01

A clear understanding of the neural basis of consciousness is fundamental to research in clinical and basic neuroscience disciplines and anesthesia. Recently, decreased efficiency of information integration was suggested as a core network feature of propofol-induced unconsciousness. However, it is unclear whether this finding can be generalized to dexmedetomidine, which has a different molecular target. Dexmedetomidine was administered as a 1-μg/kg bolus over 10 min, followed by a 0.7-μg · kg · h infusion to healthy human volunteers (age range, 18 to 36 yr; n = 15). Resting-state functional magnetic resonance imaging data were acquired during baseline, dexmedetomidine-induced altered arousal, and recovery states. Zero-lag correlations between resting-state functional magnetic resonance imaging signals extracted from 131 brain parcellations were used to construct weighted brain networks. Network efficiency, degree distribution, and node strength were computed using graph analysis. Parcellated brain regions were also mapped to known resting-state networks to study functional connectivity changes. Dexmedetomidine significantly reduced the local and global efficiencies of graph theory-derived networks. Dexmedetomidine also reduced the average brain connectivity strength without impairing the degree distribution. Functional connectivity within and between all resting-state networks was modulated by dexmedetomidine. Dexmedetomidine is associated with a significant drop in the capacity for efficient information transmission at both the local and global levels. These changes result from reductions in the strength of connectivity and also manifest as reduced within and between resting-state network connectivity. These findings strengthen the hypothesis that conscious processing relies on an efficient system of information transfer in the brain.

Wind Tunnel Tests for Wind Pressure Distribution on Gable Roof Buildings

PubMed Central

2013-01-01

Gable roof buildings are widely used in industrial buildings. Based on wind tunnel tests with rigid models, wind pressure distributions on gable roof buildings with different aspect ratios were measured simultaneously. Some characteristics of the measured wind pressure field on the surfaces of the models were analyzed, including mean wind pressure, fluctuating wind pressure, peak negative wind pressure, and characteristics of proper orthogonal decomposition results of the measured wind pressure field. The results show that extremely high local suctions often occur in the leading edges of longitudinal wall and windward roof, roof corner, and roof ridge which are the severe damaged locations under strong wind. The aspect ratio of building has a certain effect on the mean wind pressure coefficients, and the effect relates to wind attack angle. Compared with experimental results, the region division of roof corner and roof ridge from AIJ2004 is more reasonable than those from CECS102:2002 and MBMA2006.The contributions of the first several eigenvectors to the overall wind pressure distributions become much bigger. The investigation can offer some basic understanding for estimating wind load distribution on gable roof buildings and facilitate wind-resistant design of cladding components and their connections considering wind load path. PMID:24082851

An alternative approach to the Boltzmann distribution through the chemical potential

NASA Astrophysics Data System (ADS)

D'Anna, Michele; Job, Georg

2016-05-01

The Boltzmann distribution is one of the most significant results of classical physics. Despite its importance and its wide range of application, at high school level it is mostly presented without any derivation or link to some basic ideas. In this contribution we present an approach based on the chemical potential that allows to derive it directly from the basic idea of thermodynamical equilibrium.

Design principles of a microtubule polymerase

PubMed Central

Geyer, Elisabeth A; Miller, Matthew P; Brautigam, Chad A; Biggins, Sue

2018-01-01

Stu2/XMAP215 microtubule polymerases use multiple tubulin-binding TOG domains and a lattice-binding basic region to processively promote faster elongation. How the domain composition and organization of these proteins dictate polymerase activity, end localization, and processivity is unknown. We show that polymerase activity does not require different kinds of TOGs, nor are there strict requirements for how the TOGs are linked. We identify an unexpected antagonism between the tubulin-binding TOGs and the lattice-binding basic region: lattice binding by the basic region is weak when at least two TOGs engage tubulins, strong when TOGs are empty. End-localization of Stu2 requires unpolymerized tubulin, at least two TOGs, and polymerase competence. We propose a ‘ratcheting’ model for processivity: transfer of tubulin from TOGs to the lattice activates the basic region, retaining the polymerase at the end for subsequent rounds of tubulin binding and incorporation. These results clarify design principles of the polymerase. PMID:29897335

Localization of adhesins on the surface of a pathogenic bacterial envelope through atomic force microscopy

NASA Astrophysics Data System (ADS)

Arnal, L.; Longo, G.; Stupar, P.; Castez, M. F.; Cattelan, N.; Salvarezza, R. C.; Yantorno, O. M.; Kasas, S.; Vela, M. E.

2015-10-01

Bacterial adhesion is the first and a significant step in establishing infection. This adhesion normally occurs in the presence of flow of fluids. Therefore, bacterial adhesins must be able to provide high strength interactions with their target surface in order to maintain the adhered bacteria under hydromechanical stressing conditions. In the case of B. pertussis, a Gram-negative bacterium responsible for pertussis, a highly contagious human respiratory tract infection, an important protein participating in the adhesion process is a 220 kDa adhesin named filamentous haemagglutinin (FHA), an outer membrane and also secreted protein that contains recognition domains to adhere to ciliated respiratory epithelial cells and macrophages. In this work, we obtained information on the cell-surface localization and distribution of the B. pertussis adhesin FHA using an antibody-functionalized AFM tip. Through the analysis of specific molecular recognition events we built a map of the spatial distribution of the adhesin which revealed a non-homogeneous pattern. Moreover, our experiments showed a force induced reorganization of the adhesin on the surface of the cells, which could explain a reinforced adhesive response under external forces. This single-molecule information contributes to the understanding of basic molecular mechanisms used by bacterial pathogens to cause infectious disease and to gain insights into the structural features by which adhesins can act as force sensors under mechanical shear conditions.Bacterial adhesion is the first and a significant step in establishing infection. This adhesion normally occurs in the presence of flow of fluids. Therefore, bacterial adhesins must be able to provide high strength interactions with their target surface in order to maintain the adhered bacteria under hydromechanical stressing conditions. In the case of B. pertussis, a Gram-negative bacterium responsible for pertussis, a highly contagious human respiratory tract infection, an important protein participating in the adhesion process is a 220 kDa adhesin named filamentous haemagglutinin (FHA), an outer membrane and also secreted protein that contains recognition domains to adhere to ciliated respiratory epithelial cells and macrophages. In this work, we obtained information on the cell-surface localization and distribution of the B. pertussis adhesin FHA using an antibody-functionalized AFM tip. Through the analysis of specific molecular recognition events we built a map of the spatial distribution of the adhesin which revealed a non-homogeneous pattern. Moreover, our experiments showed a force induced reorganization of the adhesin on the surface of the cells, which could explain a reinforced adhesive response under external forces. This single-molecule information contributes to the understanding of basic molecular mechanisms used by bacterial pathogens to cause infectious disease and to gain insights into the structural features by which adhesins can act as force sensors under mechanical shear conditions. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr04644k

Improving Distribution Resiliency with Microgrids and State and Parameter Estimation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tuffner, Francis K.; Williams, Tess L.; Schneider, Kevin P.

Modern society relies on low-cost reliable electrical power, both to maintain industry, as well as provide basic social services to the populace. When major disturbances occur, such as Hurricane Katrina or Hurricane Sandy, the nation’s electrical infrastructure can experience significant outages. To help prevent the spread of these outages, as well as facilitating faster restoration after an outage, various aspects of improving the resiliency of the power system are needed. Two such approaches are breaking the system into smaller microgrid sections, and to have improved insight into the operations to detect failures or mis-operations before they become critical. Breaking themore » system into smaller sections of microgrid islands, power can be maintained in smaller areas where distribution generation and energy storage resources are still available, but bulk power generation is no longer connected. Additionally, microgrid systems can maintain service to local pockets of customers when there has been extensive damage to the local distribution system. However, microgrids are grid connected a majority of the time and implementing and operating a microgrid is much different than when islanded. This report discusses work conducted by the Pacific Northwest National Laboratory that developed improvements for simulation tools to capture the characteristics of microgrids and how they can be used to develop new operational strategies. These operational strategies reduce the cost of microgrid operation and increase the reliability and resilience of the nation’s electricity infrastructure. In addition to the ability to break the system into microgrids, improved observability into the state of the distribution grid can make the power system more resilient. State estimation on the transmission system already provides great insight into grid operations and detecting abnormal conditions by leveraging existing measurements. These transmission-level approaches are expanded to using advanced metering infrastructure and other distribution-level measurements to create a three-phase, unbalanced distribution state estimation approach. With distribution-level state estimation, the grid can be operated more efficiently, and outages or equipment failures can be caught faster, improving the overall resilience and reliability of the grid.« less

Convective instabilities of electromagnetic ion cyclotron waves in the outer magnetosphere

NASA Technical Reports Server (NTRS)

Horne, Richard B.; Thorne, Richard M.

1994-01-01

The path-integrated linear growth of electromagnetic ion cyclotron waves in the outer (L is greater than or equal to 7) magnetosphere is investigated using a realistic thermal plasma distribution with an additional anisotropic energetic ring current H(+) to provide free energy for instability. The results provide a realistic simulation of the recent Active Magneto- spheric Particle Tracer Explorers (AMPTE) observations. For conditions typical of the dayside magnetosphere, high plasma beta effects reduce the group velocity and significantly increase the spatial growth rates for left-handed polarized instabilities just below the helium gyrofrequency Omega(sub He(+)), and on the guided mode above Omega(sub He(+)) but below the cross over frequency omega(sub cr). Relatively high densities, typical of the afternoon local time sector, favor these low group velocity effects for predominantly field-aligned waves. Lower densities, typical of those found in the early morning local time sector, increase the group velocity but allow strong convective instabilities at high normalized frequencies well above Omega(sub He(+)). These waves are reflected in the magnetosphere and can exist for several equatorial transits without significant damping. They are left-handed polarized only on the first equatorial crossing and become linearly polarized for the remainder of the ray path. Consequently, these waves should be observed with basically linear polarization at all frequencies and all latitudes in the early morning local time sector. Wave growth below Omega(sub He(+)) is severely limited owing to the narrow bandwidth for instability and the small resonant path lengths. In the afternoon sector, where plasma densities can exceed 10(exp 7)/cu m, intense convective amplification is possible both above and below Omega(sub He(+)). Waves below Omega(sub He(+)) are not subject to reflection when the O(+) concentration is small and therefore should be observed with left-handed polarization near the equator and essentially linear polarization at higher latitudes. Since the He(+) concentration is usually large in the afternoon sector, guided mode waves above Omega(sub He(+)) reflect to form a background distribution with basically linear polarization. We suggest that the strong left-handed polarized emissions observed by AMPTE in the afternoon sector near the equator are probably due to strongly growing low group velocity waves at frequencies just below Omega(sub He(+)), and on the guided mode above Omega(sub He(+)).

Evaluation of mechanical deformation and distributive magnetic loads with different mechanical constraints in two parallel conducting bars

NASA Astrophysics Data System (ADS)

Lee, Ho-Young; Lee, Se-Hee

2017-08-01

Mechanical deformation, bending deformation, and distributive magnetic loads were evaluated numerically and experimentally for conducting materials excited with high current. Until now, many research works have extensively studied the area of magnetic force and mechanical deformation by using coupled approaches such as multiphysics solvers. In coupled analysis for magnetoelastic problems, some articles and commercial software have presented the resultant mechanical deformation and stress on the body. To evaluate the mechanical deformation, the Lorentz force density method (LZ) and the Maxwell stress tensor method (MX) have been widely used for conducting materials. However, it is difficult to find any experimental verification regarding mechanical deformation or bending deformation due to magnetic force density. Therefore, we compared our numerical results to those from experiments with two parallel conducting bars to verify our numerical setup for bending deformation. Before showing this, the basic and interesting coupled simulation was conducted to test the mechanical deformations by the LZ (body force density) and the MX (surface force density) methods. This resulted in MX gave the same total force as LZ, but the local force distribution in MX introduced an incorrect mechanical deformation in the simulation of a solid conductor.

PADF RF localization experiments with multi-agent caged-MAV platforms

NASA Astrophysics Data System (ADS)

Barber, Christopher; Gates, Miguel; Selmic, Rastko; Al-Issa, Huthaifa; Ordonez, Raul; Mitra, Atindra

2011-06-01

This paper provides a summary of preliminary RF direction finding results generated within an AFOSR funded testbed facility recently developed at Louisiana Tech University. This facility, denoted as the Louisiana Tech University Micro- Aerial Vehicle/Wireless Sensor Network (MAVSeN) Laboratory, has recently acquired a number of state-of-the-art MAV platforms that enable us to analyze, design, and test some of our recent results in the area of multiplatform position-adaptive direction finding (PADF) [1] [2] for localization of RF emitters in challenging embedded multipath environments. Discussions within the segmented sections of this paper include a description of the MAVSeN Laboratory and the preliminary results from the implementation of mobile platforms with the PADF algorithm. This novel approach to multi-platform RF direction finding is based on the investigation of iterative path-loss based (i.e. path loss exponent) metrics estimates that are measured across multiple platforms in order to develop a control law that robotically/intelligently positionally adapt (i.e. self-adjust) the location of each distributed/cooperative platform. The body of this paper provides a summary of our recent results on PADF and includes a discussion on state-of-the-art Sensor Mote Technologies as applied towards the development of sensor-integrated caged-MAV platform for PADF applications. Also, a discussion of recent experimental results that incorporate sample approaches to real-time singleplatform data pruning is included as part of a discussion on potential approaches to refining a basic PADF technique in order to integrate and perform distributed self-sensitivity and self-consistency analysis as part of a PADF technique with distributed robotic/intelligent features. These techniques are extracted in analytical form from a parallel study denoted as "PADF RF Localization Criteria for Multi-Model Scattering Environments". The focus here is on developing and reporting specific approaches to self-sensitivity and self-consistency within this experimental PADF framework via the exploitation of specific single-agent caged-MAV trajectories that are unique to this experiment set.

Basic amino acid residues located in the N-terminal region of BEND3 are essential for its nuclear localization.

PubMed

Shiheido, Hirokazu; Shimizu, Jun

2015-02-20

BEN domain-containing protein 3 (BEND3) has recently been reported to function as a heterochromatin-associated protein in transcriptional repression in the nucleus. BEND3 should have nuclear localization signals (NLSs) to localize to the nucleus in light of its molecular weight, which is higher than that allowed to pass through nuclear pore complexes. We here analyzed the subcellular localization of deletion/site-directed mutants of human BEND3 by an immunofluorescence assay in an attempt to identify the amino acids essential for its nuclear localization. We found that three basic amino acid residues located in the N-terminal region of BEND3 (BEND356-58, KRK) are essential, suggesting that these residues play a role as a functional NLS. These results provide valuable information for progressing research on BEND3. Copyright © 2015 Elsevier Inc. All rights reserved.

Predicting extinction debt from community patterns.

PubMed

Kitzes, Justin; Harte, John

2015-08-01

A significant challenge in both measuring and predicting species extinction rates at global and local scales is the possibility of extinction debt, time-delayed extinctions that occur gradually following an initial impact. Here we examine how relative abundance distributions and spatial aggregation combine to influence the likely magnitude of future extinction debt following habitat loss or climate-driven range contraction. Our analysis is based on several fundamental premises regarding abundance distributions, most importantly that species abundances immediately following habitat loss are a sample from an initial relative abundance distribution and that the long-term, steady-state form of the species abundance distribution is a property of the biology of a community and not of area. Under these two hypotheses, the results show that communities following canonical lognormal and broken-stick abundance distributions are prone to exhibit extinction debt, especially when species exhibit low spatial aggregation. Conversely, communities following a logseries distribution with a constant Fisher's α parameter never demonstrate extinction debt and often show an "immigration credit," in which species richness rises in the long term following an initial decrease. An illustration of these findings in 25 biodiversity hotspots suggests a negligible immediate extinction rate for bird communities and eventual extinction debts of 30-50% of initial species richness, whereas plant communities are predicted to immediately lose 5-15% of species without subsequent extinction debt. These results shed light on the basic determinants of extinction debt and provide initial indications of the magnitude of likely debts in landscapes where few empirical data are available.

A simple model of fluid flow and electrolyte balance in the body

NASA Technical Reports Server (NTRS)

White, R. J.; Neal, L.

1973-01-01

The model is basically a three-compartment model, the three compartments being the plasma, interstitial fluid and cellular fluid. Sodium, potassium, chloride and urea are the only major solutes considered explicitly. The control of body water and electrolyte distribution is affected via drinking and hormone levels. Basically, the model follows the effect of various oral input water loads on solute and water distribution throughout the body.

Available Energy via Nonequilibrium Thermodynamics.

ERIC Educational Resources Information Center

Woollett, E. L.

1979-01-01

Presents basic relations involving the concept of available energy that are derived from the local equations of nonequilibrium thermodynamics. The equations and applications of the local thermodynamic equilibrium LTD model are also presented. (HM)

Understanding the role of A-site and B-site cations on piezoelectric instability in lead--free (1-x) BaTiO3 -- xA(Cu1/3Nb2/3)O3 (A = Sr, Ca, Ba) solid solutions

NASA Astrophysics Data System (ADS)

Maurya, Deepam; Zhou, Yuan; Priya, Shashank

2013-03-01

This study provides fundamental understanding of the enhanced piezoelectric instability in lead-free piezoelectric (1-x) BaTiO3-xA(Cu1/3Nb2/3) O3(A: Sr, Ba and Ca and x = 0.0-0.03) solid solutions. These compositions were found to exhibit large longitudinal piezoelectric constant (d33) of ~330 pC/N and electromechanical planar coupling constant (kp) ~ 46% at room temperature. The X-ray diffraction coupled with atomic pair distribution functions (PDF)s indicated increase in local polarization. Raman scattering and electron paramagnetic resonance (EPR) analysis revealed that substitutions on A and B-site both substantially perturbed the local octahedral dynamics and resulted in localized nano polar regions with lower symmetry. The presence of nano domains and local structural distortions smears the Curie peak resulting in diffuse order-disorder type phase transitions. The effect of these distortions on the variations in physical property was modeled and analyzed within the context of nanodomains and phase transitions. *spriya@vt.edu The financial support from National Science Foundation and Office of Basic Energy Science, Department of Energy (Microscopy analysis) is gratefully acknowledged. The authors would also like to acknowledge the support from KIMS (new piezoelectric)

Modeling a hierarchical structure of factors influencing exploitation policy for water distribution systems using ISM approach

NASA Astrophysics Data System (ADS)

Jasiulewicz-Kaczmarek, Małgorzata; Wyczółkowski, Ryszard; Gładysiak, Violetta

2017-12-01

Water distribution systems are one of the basic elements of contemporary technical infrastructure of urban and rural areas. It is a complex engineering system composed of transmission networks and auxiliary equipment (e.g. controllers, checkouts etc.), scattered territorially over a large area. From the water distribution system operation point of view, its basic features are: functional variability, resulting from the need to adjust the system to temporary fluctuations in demand for water and territorial dispersion. The main research questions are: What external factors should be taken into account when developing an effective water distribution policy? Does the size and nature of the water distribution system significantly affect the exploitation policy implemented? These questions have shaped the objectives of research and the method of research implementation.

Implementing local agency safety management

DOT National Transportation Integrated Search

2003-12-17

For local agencies to mount a successful effort toward reducing motor vehicle collisions and their costs, an effective systematic approach must be taken. A Safety Management System (SMS) has two basic components: a collaborative information exchange ...

Nondestructive Testing Eddy Current Basic Principles RQA/M1-5330.12 (V-I).

ERIC Educational Resources Information Center

National Aeronautics and Space Administration, Huntsville, AL. George C. Marshall Space Flight Center.

As one in the series of programmed instruction handbooks, prepared by the U.S. space program, home study material is presented in this volume concerning familiarization and orientation on basic eddy current principles. The subject is presented under the following headings: Basic Eddy Current Concepts, Eddy Current Generation and Distribution,…

Fracture mechanics concepts in reliability analysis of monolithic ceramics

NASA Technical Reports Server (NTRS)

Manderscheid, Jane M.; Gyekenyesi, John P.

1987-01-01

Basic design concepts for high-performance, monolithic ceramic structural components are addressed. The design of brittle ceramics differs from that of ductile metals because of the inability of ceramic materials to redistribute high local stresses caused by inherent flaws. Random flaw size and orientation requires that a probabilistic analysis be performed in order to determine component reliability. The current trend in probabilistic analysis is to combine linear elastic fracture mechanics concepts with the two parameter Weibull distribution function to predict component reliability under multiaxial stress states. Nondestructive evaluation supports this analytical effort by supplying data during verification testing. It can also help to determine statistical parameters which describe the material strength variation, in particular the material threshold strength (the third Weibull parameter), which in the past was often taken as zero for simplicity.

Development of Time-Distance Helioseismology Data Analysis Pipeline for SDO/HMI

NASA Technical Reports Server (NTRS)

DuVall, T. L., Jr.; Zhao, J.; Couvidat, S.; Parchevsky, K. V.; Beck, J.; Kosovichev, A. G.; Scherrer, P. H.

2008-01-01

The Helioseismic and Magnetic Imager of SDO will provide uninterrupted 4k x 4k-pixel Doppler-shift images of the Sun with approximately 40 sec cadence. These data will have a unique potential for advancing local helioseismic diagnostics of the Sun's interior structure and dynamics. They will help to understand the basic mechanisms of solar activity and develop predictive capabilities for NASA's Living with a Star program. Because of the tremendous amount of data the HMI team is developing a data analysis pipeline, which will provide maps of subsurface flows and sound-speed distributions inferred form the Doppler data by the time-distance technique. We discuss the development plan, methods, and algorithms, and present the status of the pipeline, testing results and examples of the data products.

Analysis and improvements of Adaptive Particle Refinement (APR) through CPU time, accuracy and robustness considerations

NASA Astrophysics Data System (ADS)

Chiron, L.; Oger, G.; de Leffe, M.; Le Touzé, D.

2018-02-01

While smoothed-particle hydrodynamics (SPH) simulations are usually performed using uniform particle distributions, local particle refinement techniques have been developed to concentrate fine spatial resolutions in identified areas of interest. Although the formalism of this method is relatively easy to implement, its robustness at coarse/fine interfaces can be problematic. Analysis performed in [16] shows that the radius of refined particles should be greater than half the radius of unrefined particles to ensure robustness. In this article, the basics of an Adaptive Particle Refinement (APR) technique, inspired by AMR in mesh-based methods, are presented. This approach ensures robustness with alleviated constraints. Simulations applying the new formalism proposed achieve accuracy comparable to fully refined spatial resolutions, together with robustness, low CPU times and maintained parallel efficiency.

Local Influence Analysis of Nonlinear Structural Equation Models

ERIC Educational Resources Information Center

Lee, Sik-Yum; Tang, Nian-Sheng

2004-01-01

By regarding the latent random vectors as hypothetical missing data and based on the conditional expectation of the complete-data log-likelihood function in the EM algorithm, we investigate assessment of local influence of various perturbation schemes in a nonlinear structural equation model. The basic building blocks of local influence analysis…

Between the Lines. A Basic Skills Newspaper Pack.

ERIC Educational Resources Information Center

Adult Literacy and Basic Skills Unit, London (England).

This document incorporates source materials from local and regional newspapers from different parts of the United Kingdom into learning activities to develop literacy skills. The activities are organized into seven sections as follows: local newspapers (types of local newspapers, regular and special features, columns and blocks, and reading the…

Qualitative Inquiry into Local Education Administration in Pakistan

ERIC Educational Resources Information Center

Komatsu, Taro

2009-01-01

The level of educational development in Pakistan is low. A decentralisation reform was introduced in 2000 to improve the delivery of basic education by designating the local government body with primary responsibility for administering it. A qualitative field study on local education administration at the North West Frontier Province found…

Chapter 1 Policy Manual. Basic Programs Operated by Local Educational Agencies. Part A of Chapter 1 of Title I, Elementary and Secondary Education Act of 1965 amended by the Augustus F. Hawkins-Robert T. Stafford Elementary and Secondary School Improvement Amendments of 1988 (Public Law 100-297).

ERIC Educational Resources Information Center

Office of Educational Research and Improvement (ED), Washington, DC.

This policy manual is a guide for state education agencies (SEAs), local education agencies (LEAs), parents, and other interested parties wishing to obtain funding for basic compensatory education programs operated by school districts under Part A of Chapter 1 of Title I of the Elementary and Secondary Education Act of 1965 (ESEA), as amended by…

Genome-wide network of regulatory genes for construction of a chordate embryo.

PubMed

Shoguchi, Eiichi; Hamaguchi, Makoto; Satoh, Nori

2008-04-15

Animal development is controlled by gene regulation networks that are composed of sequence-specific transcription factors (TF) and cell signaling molecules (ST). Although housekeeping genes have been reported to show clustering in the animal genomes, whether the genes comprising a given regulatory network are physically clustered on a chromosome is uncertain. We examined this question in the present study. Ascidians are the closest living relatives of vertebrates, and their tadpole-type larva represents the basic body plan of chordates. The Ciona intestinalis genome contains 390 core TF genes and 119 major ST genes. Previous gene disruption assays led to the formulation of a basic chordate embryonic blueprint, based on over 3000 genetic interactions among 79 zygotic regulatory genes. Here, we mapped the regulatory genes, including all 79 regulatory genes, on the 14 pairs of Ciona chromosomes by fluorescent in situ hybridization (FISH). Chromosomal localization of upstream and downstream regulatory genes demonstrates that the components of coherent developmental gene networks are evenly distributed over the 14 chromosomes. Thus, this study provides the first comprehensive evidence that the physical clustering of regulatory genes, or their target genes, is not relevant for the genome-wide control of gene expression during development.

Surface water records of New Mexico, water year 1963

USGS Publications Warehouse

,

1964-01-01

This report is the third in a series presenting, annually, basic data on surface-water records by States. Through September 30, 1960, the records of discharge and stage of streams and contents and stage of lakes or reservoirs were published in an annual series of U. S. Geological Survey water-supply papers entitled "Surface Water Supply of the United States". Since 1951 there have been 20 volumes in the series; each volume covered an area whose boundaries coincided with those of certain natural drainage areas. The records in New Mexico were contained in Parts 7, 8, and 9 of that series. Beginning with the 1961 water year, streamflow records and related data will be released by the Geological Survey in annual reports on a State-boundary basis. Distribution of these basic-data reports will be limited and primarily for local needs. The records later will be published in Geological Survey water-supply papers at 5- year intervals. These 5-year water-supply papers will show daily discharge and will be compiled on the same geographical areas previously used for the annual series; however, some of the 14 parts of conterminous United States will be further subdivided.

Optically programmable encoder based on light propagation in two-dimensional regular nanoplates.

PubMed

Li, Ya; Zhao, Fangyin; Guo, Shuai; Zhang, Yongyou; Niu, Chunhui; Zeng, Ruosheng; Zou, Bingsuo; Zhang, Wensheng; Ding, Kang; Bukhtiar, Arfan; Liu, Ruibin

2017-04-07

We design an efficient optically controlled microdevice based on CdSe nanoplates. Two-dimensional CdSe nanoplates exhibit lighting patterns around the edges and can be realized as a new type of optically controlled programmable encoder. The light source is used to excite the nanoplates and control the logical position under vertical pumping mode by the objective lens. At each excitation point in the nanoplates, the preferred light-propagation routes are along the normal direction and perpendicular to the edges, which then emit out from the edges to form a localized lighting section. The intensity distribution around the edges of different nanoplates demonstrates that the lighting part with a small scale is much stronger, defined as '1', than the dark section, defined as '0', along the edge. These '0' and '1' are the basic logic elements needed to compose logically functional devices. The observed propagation rules are consistent with theoretical simulations, meaning that the guided-light route in two-dimensional semiconductor nanoplates is regular and predictable. The same situation was also observed in regular CdS nanoplates. Basic theoretical analysis and experiments prove that the guided light and exit position follow rules mainly originating from the shape rather than material itself.

Kinetic and calorimetric study of the adsorption of dyes on mesoporous activated carbon prepared from coconut coir dust.

PubMed

Macedo, Jeremias de Souza; da Costa Júnior, Nivan Bezerra; Almeida, Luis Eduardo; Vieira, Eunice Fragoso da Silva; Cestari, Antonio Reinaldo; Gimenez, Iara de Fátima; Villarreal Carreño, Neftali Lênin; Barreto, Ledjane Silva

2006-06-15

Mesoporous activated carbon has been prepared from coconut coir dust as support for adsorption of some model dye molecules from aqueous solutions. The methylene blue (MB) and remazol yellow (RY) molecules were chosen for study of the adsorption capacity of cationic and anionic dyes onto prepared activated carbon. The adsorption kinetics was studied with the Lagergren first- and pseudo-second-order kinetic models as well as the intraparticle diffusion model. The results for both dyes suggested a multimechanism sorption process. The adsorption mechanisms in the systems dyes/AC follow pseudo-second-order kinetics with a significant contribution of intraparticle diffusion. The samples simultaneously present acidic and basic sites able to act as anchoring sites for basic and acidic dyes, respectively. Calorimetric studies reveal that dyes/AC interaction forces are correlated with the pH of the solution, which can be related to the charge distribution on the AC surface. These AC samples also exhibited very short equilibrium times for the adsorption of both dyes, which is an economically favorable requisite for the activated carbon described in this work, in addition to the local abundance of the raw material.

The Design of a High Performance Earth Imagery and Raster Data Management and Processing Platform

NASA Astrophysics Data System (ADS)

Xie, Qingyun

2016-06-01

This paper summarizes the general requirements and specific characteristics of both geospatial raster database management system and raster data processing platform from a domain-specific perspective as well as from a computing point of view. It also discusses the need of tight integration between the database system and the processing system. These requirements resulted in Oracle Spatial GeoRaster, a global scale and high performance earth imagery and raster data management and processing platform. The rationale, design, implementation, and benefits of Oracle Spatial GeoRaster are described. Basically, as a database management system, GeoRaster defines an integrated raster data model, supports image compression, data manipulation, general and spatial indices, content and context based queries and updates, versioning, concurrency, security, replication, standby, backup and recovery, multitenancy, and ETL. It provides high scalability using computer and storage clustering. As a raster data processing platform, GeoRaster provides basic operations, image processing, raster analytics, and data distribution featuring high performance computing (HPC). Specifically, HPC features include locality computing, concurrent processing, parallel processing, and in-memory computing. In addition, the APIs and the plug-in architecture are discussed.

Distributed bearing fault diagnosis based on vibration analysis

NASA Astrophysics Data System (ADS)

Dolenc, Boštjan; Boškoski, Pavle; Juričić, Đani

2016-01-01

Distributed bearing faults appear under various circumstances, for example due to electroerosion or the progression of localized faults. Bearings with distributed faults tend to generate more complex vibration patterns than those with localized faults. Despite the frequent occurrence of such faults, their diagnosis has attracted limited attention. This paper examines a method for the diagnosis of distributed bearing faults employing vibration analysis. The vibrational patterns generated are modeled by incorporating the geometrical imperfections of the bearing components. Comparing envelope spectra of vibration signals shows that one can distinguish between localized and distributed faults. Furthermore, a diagnostic procedure for the detection of distributed faults is proposed. This is evaluated on several bearings with naturally born distributed faults, which are compared with fault-free bearings and bearings with localized faults. It is shown experimentally that features extracted from vibrations in fault-free, localized and distributed fault conditions form clearly separable clusters, thus enabling diagnosis.

Basic Automotive Mechanics. Florida Vocational Program Guide.

ERIC Educational Resources Information Center

University of South Florida, Tampa. Dept. of Adult and Vocational Education.

This program guide identifies primary concerns in the organization, operation, and evaluation of a basic automotive mechanics program. It is designed for local school district and community college administrators, instructors, program advisory committees, and regional coordinating councils. The guide begins with the Dictionary of Occupational…

Current Events in Basic Business Education

ERIC Educational Resources Information Center

Van Hook, Barry L.

1974-01-01

The author suggests the use of current events to stimulate student interest in basic business courses. Suggested topics described are monetary devaluation, interest rate adjustments, Illinois no-fault automobile insurance, labor-management disputes, Dow-Jones average, Picasso's death, energy crisis, sale of surplus wheat, local consumer assistance…

Teaching Basic Science Environmentally, Concept: Water that Comes Down as Rain Is Used Over and Over Again.

ERIC Educational Resources Information Center

Busch, Phyllis S.

1985-01-01

Provides directions for basic science experiments which demonstrate the rain cycle, fundamentals of cloud formation, and testing for the presence of acidity in local rainwater. Describes materials required, step-by-step instructions, and discussion topics. (NEC)

Application of Local Discretization Methods in the NASA Finite-Volume General Circulation Model

NASA Technical Reports Server (NTRS)

Yeh, Kao-San; Lin, Shian-Jiann; Rood, Richard B.

2002-01-01

We present the basic ideas of the dynamics system of the finite-volume General Circulation Model developed at NASA Goddard Space Flight Center for climate simulations and other applications in meteorology. The dynamics of this model is designed with emphases on conservative and monotonic transport, where the property of Lagrangian conservation is used to maintain the physical consistency of the computational fluid for long-term simulations. As the model benefits from the noise-free solutions of monotonic finite-volume transport schemes, the property of Lagrangian conservation also partly compensates the accuracy of transport for the diffusion effects due to the treatment of monotonicity. By faithfully maintaining the fundamental laws of physics during the computation, this model is able to achieve sufficient accuracy for the global consistency of climate processes. Because the computing algorithms are based on local memory, this model has the advantage of efficiency in parallel computation with distributed memory. Further research is yet desirable to reduce the diffusion effects of monotonic transport for better accuracy, and to mitigate the limitation due to fast-moving gravity waves for better efficiency.

Heat and mass transfer are in the interaction of multi-pulsed spray with vertical surfaces in the regime of evaporative cooling

NASA Astrophysics Data System (ADS)

Karpov, P. N.; Nazarov, A. D.; Serov, A. F.; Terekhov, V. I.

2017-10-01

Sprays with a periodic supply drop phase have great opportunities to control the processes of heat transfer. We can achieve optimal evaporative modes of cooling by changing the pulse duration and the repetition frequency while minimizing flow of the liquid phase. Experimental data of investigation of local heat transfer for poorly heated large surface obtained on the original stand with multi nozzle managed the irrigation system impact of the gas-droplet flow present in this work. Researches on the contribution to the intensification of spray options were conducted. Also the growth rate was integral and local heat. Information instantaneous distribution of the heat flux in the description of the processes have helped us. Managed to describe two basic modes of heat transfer: Mode “insular” foil cooling and thick foil with forming of streams. Capacitive sensors allow to monitor the dynamics of the foil thickness, the birth-belt flow, forming and the evolution of waves generated by “bombing” the surface with the droplets.

Malaria vector species in Colombia - A review

PubMed Central

Montoya-Lerma, James; Solarte, Yezid A; Giraldo-Calderón, Gloria Isabel; Quiñones, Martha L; Ruiz-López, Freddy; Wilkerson, Richard C; González, Ranulfo

2016-01-01

Here we present a comprehensive review of the literature on the vectorial importance of the major Anopheles malaria vectors in Colombia. We provide basic information on the geographical distribution, altitudinal range, immature habitats, adult behaviour, feeding preferences and anthropophily, endophily and infectivity rates. We additionally review information on the life cycle, longevity and population fluctuation of Colombian Anopheles species. Emphasis was placed on the primary vectors that have been epidemiologically incriminated in malaria transmission: Anopheles darlingi, Anopheles albimanus and Anopheles nuneztovari. The role of a selection of local, regional or secondary vectors (e.g., Anopheles pseudopunctipennis and Anopheles neivai) is also discussed. We highlight the importance of combining biological, morphological and molecular data for the correct taxonomical determination of a given species, particularly for members of the species complexes. We likewise emphasise the importance of studying the bionomics of primary and secondary vectors along with an examination of the local conditions affecting the transmission of malaria. The presence and spread of the major vectors and the emergence of secondary species capable of transmitting human Plasmodia are of great interest. When selecting control measures, the anopheline diversity in the region must be considered. Variation in macroclimate conditions over a species’ geographical range must be well understood and targeted to plan effective control measures based on the population dynamics of the local Anopheles species. PMID:21881778

Production of antiretroviral drugs in middle- and low-income countries.

PubMed

Pinheiro, Eloan dos Santos; Brüning, Karin; Macedo, M Fernanda; Siani, Antonio C

2014-01-01

This review outlines the main issues concerning the production of antiretroviral (ARV) drugs in middle- and low-income countries and the relevant political, legal and technical requirements for supporting such production. The requirements for efficient local production, including the manufacture of generic and branded products and public demand, have been considered from economic, market and socio-political perspectives. A steady and consistent government policy is crucial to success. Additional crucial factors in establishing local production are adequate infrastructure, qualified human resources in technical and managerial areas, and production-distribution logistics systems. The creation or strengthening of a national drug regulatory agency is a basic requirement. Production of ARVs relies on the structure of the international market for active pharmaceutical ingredients (APIs), which are highly monopolized for inclusion in branded or patented drugs, or are concentrated in a few Asian generic companies. Countries seeking to begin local production must develop strategies to overcome the various barriers. For instance, sub-Saharan African countries may benefit from developing multilateral health agreements with neighbouring countries. Such agreements are recommended and should be complemented by technology transfers, especially for the manufacture of APIs. Achieving a production level that is sustainable in the long term is crucial to maintaining patients' access to ARVs.

Distribution and depth of bottom-simulating reflectors in the Nankai subduction margin.

PubMed

Ohde, Akihiro; Otsuka, Hironori; Kioka, Arata; Ashi, Juichiro

2018-01-01

Surface heat flow has been observed to be highly variable in the Nankai subduction margin. This study presents an investigation of local anomalies in surface heat flows on the undulating seafloor in the Nankai subduction margin. We estimate the heat flows from bottom-simulating reflectors (BSRs) marking the lower boundaries of the methane hydrate stability zone and evaluate topographic effects on heat flow via two-dimensional thermal modeling. BSRs have been used to estimate heat flows based on the known stability characteristics of methane hydrates under low-temperature and high-pressure conditions. First, we generate an extensive map of the distribution and subseafloor depths of the BSRs in the Nankai subduction margin. We confirm that BSRs exist at the toe of the accretionary prism and the trough floor of the offshore Tokai region, where BSRs had previously been thought to be absent. Second, we calculate the BSR-derived heat flow and evaluate the associated errors. We conclude that the total uncertainty of the BSR-derived heat flow should be within 25%, considering allowable ranges in the P-wave velocity, which influences the time-to-depth conversion of the BSR position in seismic images, the resultant geothermal gradient, and thermal resistance. Finally, we model a two-dimensional thermal structure by comparing the temperatures at the observed BSR depths with the calculated temperatures at the same depths. The thermal modeling reveals that most local variations in BSR depth over the undulating seafloor can be explained by topographic effects. Those areas that cannot be explained by topographic effects can be mainly attributed to advective fluid flow, regional rapid sedimentation, or erosion. Our spatial distribution of heat flow data provides indispensable basic data for numerical studies of subduction zone modeling to evaluate margin parallel age dependencies of subducting plates.

Transient ensemble dynamics in time-independent galactic potentials

NASA Astrophysics Data System (ADS)

Mahon, M. Elaine; Abernathy, Robert A.; Bradley, Brendan O.; Kandrup, Henry E.

1995-07-01

This paper summarizes a numerical investigation of the short-time, possibly transient, behaviour of ensembles of stochastic orbits evolving in fixed non-integrable potentials, with the aim of deriving insights into the structure and evolution of galaxies. The simulations involved three different two-dimensional potentials, quite different in appearance. However, despite these differences, ensembles in all three potentials exhibit similar behaviour. This suggests that the conclusions inferred from the simulations are robust, relying only on basic topological properties, e.g., the existence of KAM tori and cantori. Generic ensembles of initial conditions, corresponding to stochastic orbits, exhibit a rapid coarse-grained approach towards a near-invariant distribution on a time-scale <>t_H, although various irregularities associated with external and/or internal irregularities can drastically accelerate this process. A principal tool in the analysis is the notion of a local Liapounov exponent, which provides a statistical characterization of the overall instability of stochastic orbits over finite time intervals. In particular, there is a precise sense in which confined stochastic orbits are less unstable, with smaller local Liapounov exponents, than are unconfined stochastic orbits.

Basic visual dysfunction allows classification of patients with schizophrenia with exceptional accuracy.

PubMed

González-Hernández, J A; Pita-Alcorta, C; Padrón, A; Finalé, A; Galán, L; Martínez, E; Díaz-Comas, L; Samper-González, J A; Lencer, R; Marot, M

2014-10-01

Basic visual dysfunctions are commonly reported in schizophrenia; however their value as diagnostic tools remains uncertain. This study reports a novel electrophysiological approach using checkerboard visual evoked potentials (VEP). Sources of spectral resolution VEP-components C1, P1 and N1 were estimated by LORETA, and the band-effects (BSE) on these estimated sources were explored in each subject. BSEs were Z-transformed for each component and relationships with clinical variables were assessed. Clinical effects were evaluated by ROC-curves and predictive values. Forty-eight patients with schizophrenia (SZ) and 55 healthy controls participated in the study. For each of the 48 patients, the three VEP components were localized to both dorsal and ventral brain areas and also deviated from a normal distribution. P1 and N1 deviations were independent of treatment, illness chronicity or gender. Results from LORETA also suggest that deficits in thalamus, posterior cingulum, precuneus, superior parietal and medial occipitotemporal areas were associated with symptom severity. While positive symptoms were more strongly related to sensory processing deficits (P1), negative symptoms were more strongly related to perceptual processing dysfunction (N1). Clinical validation revealed positive and negative predictive values for correctly classifying SZ of 100% and 77%, respectively. Classification in an additional independent sample of 30 SZ corroborated these results. In summary, this novel approach revealed basic visual dysfunctions in all patients with schizophrenia, suggesting these visual dysfunctions represent a promising candidate as a biomarker for schizophrenia. Copyright © 2014 Elsevier B.V. All rights reserved.

Myelin management by the 18.5–kDa and 21.5–kDa classic myelin basic protein isoforms

PubMed Central

Harauz, George; Boggs, Joan M.

2013-01-01

The classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in maturing oligodendrocytes. The 18.5-kDa isoform that predominates in adult myelin adheres the cytosolic surfaces of oligodendrocyte membranes together, and forms a two-dimensional molecular sieve restricting protein diffusion into compact myelin. However, this protein has additional roles including cytoskeletal assembly and membrane extension, binding to SH3-domains, participation in Fyn-mediated signaling pathways, sequestration of phosphoinositides, and maintenance of calcium homeostasis. Of the diverse post-translational modifications of this isoform, phosphorylation is the most dynamic, and modulates 18.5-kDa MBP’s protein-membrane and protein-protein interactions, indicative of a rich repertoire of functions. In developing and mature myelin, phosphorylation can result in microdomain or even nuclear targeting of the protein, supporting the conclusion that 18.5-kDa MBP has significant roles beyond membrane adhesion. The full-length, early-developmental 21.5-kDa splice isoform is predominantly karyophilic due to a non-traditional P-Y nuclear localization signal, with effects such as promotion of oligodendrocyte proliferation. We discuss in vitro and recent in vivo evidence for multifunctionality of these classic basic proteins of myelin, and argue for a systematic evaluation of the temporal and spatial distributions of these protein isoforms, and their modified variants, during oligodendrocyte differentiation. PMID:23398367

Density Functionals of Chemical Bonding

PubMed Central

Putz, Mihai V.

2008-01-01

The behavior of electrons in general many-electronic systems throughout the density functionals of energy is reviewed. The basic physico-chemical concepts of density functional theory are employed to highlight the energy role in chemical structure while its extended influence in electronic localization function helps in chemical bonding understanding. In this context the energy functionals accompanied by electronic localization functions may provide a comprehensive description of the global-local levels electronic structures in general and of chemical bonds in special. Becke-Edgecombe and author’s Markovian electronic localization functions are discussed at atomic, molecular and solid state levels. Then, the analytical survey of the main workable kinetic, exchange, and correlation density functionals within local and gradient density approximations is undertaken. The hierarchy of various energy functionals is formulated by employing both the parabolic and statistical correlation degree of them with the electronegativity and chemical hardness indices by means of quantitative structure-property relationship (QSPR) analysis for basic atomic and molecular systems. PMID:19325846

Teaching the Rules of Debit and Credit

ERIC Educational Resources Information Center

Potts, Andrew J.

1974-01-01

A fundamental method of explaining the basic accounting principles and concepts (debit, credit, basic accounting equation) which includes visual aids, reference to local businesses, and drill, does much toward increasing the student's skill and enhancing his understanding of the subject matter. (Sample transparencies are included.) (Author/AJ)

34 CFR 461.31 - How does a State award funds?

Code of Federal Regulations, 2011 CFR

2011-07-01

... ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION STATE-ADMINISTERED BASIC GRANT PROGRAM How Does... adults; (3) Describes a project that gives special emphasis to adult basic education; (4) Describes... assistance from Federal, State, and local sources that provide adult education in the geographic area...

34 CFR 461.31 - How does a State award funds?

Code of Federal Regulations, 2012 CFR

2012-07-01

... ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION STATE-ADMINISTERED BASIC GRANT PROGRAM How Does... adults; (3) Describes a project that gives special emphasis to adult basic education; (4) Describes... assistance from Federal, State, and local sources that provide adult education in the geographic area...

34 CFR 461.31 - How does a State award funds?

Code of Federal Regulations, 2013 CFR

2013-07-01

... ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION STATE-ADMINISTERED BASIC GRANT PROGRAM How Does... adults; (3) Describes a project that gives special emphasis to adult basic education; (4) Describes... assistance from Federal, State, and local sources that provide adult education in the geographic area...

34 CFR 461.31 - How does a State award funds?

Code of Federal Regulations, 2014 CFR

2014-07-01

... ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION STATE-ADMINISTERED BASIC GRANT PROGRAM How Does... adults; (3) Describes a project that gives special emphasis to adult basic education; (4) Describes... assistance from Federal, State, and local sources that provide adult education in the geographic area...

Associations of Postural Knowledge and Basic Motor Skill with Dyspraxia in Autism: Implication for Abnormalities in Distributed Connectivity and Motor Learning

PubMed Central

Dowell, Lauren R.; Mahone, E. Mark; Mostofsky, Stewart H.

2009-01-01

Children with autism often have difficulty performing skilled movements. Praxis performance requires basic motor skill, knowledge of representations of the movement (mediated by parietal regions), and transcoding of these representations into movement plans (mediated by premotor circuits). The goals of this study were: (a) to determine whether dyspraxia in autism is associated with impaired representational (“postural”) knowledge, and (b) to examine the contributions of postural knowledge and basic motor skill to dyspraxia in autism. Thirty-seven children with autism spectrum disorder (ASD) and 50 typically developing (TD) children, ages 8–13, completed: (a) an examination of basic motor skills, (b) a postural knowledge test assessing praxis discrimination, and (c) a praxis examination. Children with ASD showed worse basic motor skill and postural knowledge than controls. The ASD group continued to show significantly poorer praxis than controls after accounting for age, IQ, basic motor skill, and postural knowledge. Dyspraxia in autism appears to be associated with impaired formation of spatial representations, as well as transcoding and execution. Distributed abnormality across parietal, premotor, and motor circuitry, as well as anomalous connectivity may be implicated. PMID:19702410

Preparing for Educational Change: Incorporating the Support Curriculum into the Basic Curriculum.

ERIC Educational Resources Information Center

Hannifin, Michael J.; Barrett, Bradley K.

1983-01-01

Increased local control for support programs formerly federally funded will require planning and coordination. Curriculum systematization is a process for determining the compatibility of support programs with the existing local curriculum. (SK)

Identification of multiple nuclear localization signals in murine Elf3, an ETS transcription factor.

PubMed

Do, Hyun-Jin; Song, Hyuk; Yang, Heung-Mo; Kim, Dong-Ku; Kim, Nam-Hyung; Kim, Jin-Hoi; Cha, Kwang-Yul; Chung, Hyung-Min; Kim, Jae-Hwan

2006-03-20

We investigated nuclear localization signal (NLS) determinants within the AT-hook and ETS DNA-binding domains of murine Elf3 (mElf3), a member of the subfamily of epithelium-specific ETS transcription factors. Deletion mutants containing the AT-hook, ETS domain or both localized strictly in the nucleus, suggesting that these individual domains contain independent NLS motif(s). Within the AT-hook domain, four basic residues (244KRKR247) were critical for strong NLS activity, and two potent bipartite NLS motifs (236-252 and 249-267) were sufficient for nuclear import of mElf3, although less efficient than the full domain. In addition, one stretch of basic residues (318KKK320) within the ETS domain appears to be essential for mElf3 nuclear localization. Taken together, mElf3 contains multiple NLS motifs, which may function cooperatively to effect efficient nuclear transport.

An analysis of spatial and socio-economic determinants of tuberculosis in Hermosillo, Mexico, 2000-2006.

PubMed

Alvarez-Hernández, G; Lara-Valencia, F; Reyes-Castro, P A; Rascón-Pacheco, R A

2010-06-01

The city of Hermosillo, in Northwest Mexico, has a higher incidence of tuberculosis (TB) than the national average. However, the intra-urban TB distribution, which could limit the effectiveness of preventive strategies and control, is unknown. Using geographic information systems (GIS) and spatial analysis, we characterized the geographical distribution of TB by basic geostatistical area (BGA), and compared it with a social deprivation index. Univariate and bivariate techniques were used to detect risk areas. Globally, TB in the city of Hermosillo is not spatially auto-correlated, but local clusters with high incidence and mortality rates were identified in the northwest, central-east and southwest sections of the city. BGAs with high social deprivation had an excess risk of TB. GIS and spatial analysis are useful tools to detect high TB risk areas in the city of Hermosillo. Such areas may be vulnerable due to low socio-economic status. The study of small geographical areas in urban settings similar to Hermosillo could indicate the best course of action to be taken for TB prevention and control.

Energy storage requirements of dc microgrids with high penetration renewables under droop control

DOE PAGES

Weaver, Wayne W.; Robinett, Rush D.; Parker, Gordon G.; ...

2015-01-09

Energy storage is a important design component in microgrids with high penetration renewable sources to maintain the system because of the highly variable and sometimes stochastic nature of the sources. Storage devices can be distributed close to the sources and/or at the microgrid bus. In addition, storage requirements can be minimized with a centralized control architecture, but this creates a single point of failure. Distributed droop control enables a completely decentralized architecture but, the energy storage optimization becomes more difficult. Our paper presents an approach to droop control that enables the local and bus storage requirements to be determined. Givenmore » a priori knowledge of the design structure of a microgrid and the basic cycles of the renewable sources, we found that the droop settings of the sources are such that they minimize both the bus voltage variations and overall energy storage capacity required in the system. This approach can be used in the design phase of a microgrid with a decentralized control structure to determine appropriate droop settings as well as the sizing of energy storage devices.« less

Mutations of amino acids in the DNA-recognition domain of Epstein-Barr virus ZEBRA protein alter its sub-nuclear localization and affect formation of replication compartments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, Richard; Heston, Lee; Shedd, Duane

ZEBRA, a transcription factor and DNA replication protein encoded by the Epstein-Barr virus (EBV) BZLF1 gene, plays indispensable roles in the EBV lytic cycle. We recently described the phenotypes of 46 single amino acid substitutions introduced into the DNA-recognition region of ZEBRA [Heston, L., El-Guindy, A., Countryman, J., Dela Cruz, C., Delecluse, H.J., and Miller, G. 2006]. The 27 DNA-binding-proficient mutants exhibited distinct defects in their ability to activate expression of the kinetic classes of viral genes. Four phenotypic variants could be discerned: wild-type, defective at activating Rta, defective at activating early genes, and defective at activating late genes. Heremore » we analyze the distribution of ZEBRA within the nucleus and the localization of EA-D (the viral DNA polymerase processivity factor), an indicator of the development of replication compartments, in representatives of each phenotypic group. Plasmids encoding wild-type (WT) and mutant ZEBRA were transfected into 293 cells containing EBV-bacmids. WT ZEBRA protein was diffusely and smoothly distributed throughout the nucleus, sparing nucleoli, and partially recruited to globular replication compartments. EA-D induced by WT ZEBRA was present diffusely in some cells and concentrated in globular replication compartments in other cells. The distribution of ZEBRA and EA-D proteins was identical to WT following transfection of K188R, a mutant with a conservative change. The distribution of S186A mutant ZEBRA protein, defective for activation of Rta and EA-D, was identical to WT, except that the mutant ZEBRA was never found in globular compartments. Co-expression of Rta with S186A mutant rescued diffuse EA-D but not globular replication compartments. The most striking observation was that several mutant ZEBRA proteins defective in activating EA-D (R179A, K181A and A185V) and defective in activating lytic viral DNA replication and late genes (Y180E and K188A) were localized to numerous punctate foci. The speckled appearance of R179A and Y180E was more regular and clearly defined in EBV-positive than in EBV-negative 293 cells. The Y180E late-mutant induced EA-D, but prevented EA-D from localizing to globular replication compartments. These results show that individual amino acids within the basic domain influence localization of the ZEBRA protein and its capacity to induce EA-D to become located in mature viral replication compartments. Furthermore, these mutant ZEBRA proteins delineate several stages in the processes of nuclear re-organization which accompany lytic EBV replication.« less

Weighted low-rank sparse model via nuclear norm minimization for bearing fault detection

NASA Astrophysics Data System (ADS)

Du, Zhaohui; Chen, Xuefeng; Zhang, Han; Yang, Boyuan; Zhai, Zhi; Yan, Ruqiang

2017-07-01

It is a fundamental task in the machine fault diagnosis community to detect impulsive signatures generated by the localized faults of bearings. The main goal of this paper is to exploit the low-rank physical structure of periodic impulsive features and further establish a weighted low-rank sparse model for bearing fault detection. The proposed model mainly consists of three basic components: an adaptive partition window, a nuclear norm regularization and a weighted sequence. Firstly, due to the periodic repetition mechanism of impulsive feature, an adaptive partition window could be designed to transform the impulsive feature into a data matrix. The highlight of partition window is to accumulate all local feature information and align them. Then, all columns of the data matrix share similar waveforms and a core physical phenomenon arises, i.e., these singular values of the data matrix demonstrates a sparse distribution pattern. Therefore, a nuclear norm regularization is enforced to capture that sparse prior. However, the nuclear norm regularization treats all singular values equally and thus ignores one basic fact that larger singular values have more information volume of impulsive features and should be preserved as much as possible. Therefore, a weighted sequence with adaptively tuning weights inversely proportional to singular amplitude is adopted to guarantee the distribution consistence of large singular values. On the other hand, the proposed model is difficult to solve due to its non-convexity and thus a new algorithm is developed to search one satisfying stationary solution through alternatively implementing one proximal operator operation and least-square fitting. Moreover, the sensitivity analysis and selection principles of algorithmic parameters are comprehensively investigated through a set of numerical experiments, which shows that the proposed method is robust and only has a few adjustable parameters. Lastly, the proposed model is applied to the wind turbine (WT) bearing fault detection and its effectiveness is sufficiently verified. Compared with the current popular bearing fault diagnosis techniques, wavelet analysis and spectral kurtosis, our model achieves a higher diagnostic accuracy.

Analysis and attenuation of artifacts caused by spatially and temporally correlated noise sources in Green's function estimates

NASA Astrophysics Data System (ADS)

Martin, E. R.; Dou, S.; Lindsey, N.; Chang, J. P.; Biondi, B. C.; Ajo Franklin, J. B.; Wagner, A. M.; Bjella, K.; Daley, T. M.; Freifeld, B. M.; Robertson, M.; Ulrich, C.; Williams, E. F.

2016-12-01

Localized strong sources of noise in an array have been shown to cause artifacts in Green's function estimates obtained via cross-correlation. Their effect is often reduced through the use of cross-coherence. Beyond independent localized sources, temporally or spatially correlated sources of noise frequently occur in practice but violate basic assumptions of much of the theory behind ambient noise Green's function retrieval. These correlated noise sources can occur in urban environments due to transportation infrastructure, or in areas around industrial operations like pumps running at CO2 sequestration sites or oil and gas drilling sites. Better understanding of these artifacts should help us develop and justify methods for their automatic removal from Green's function estimates. We derive expected artifacts in cross-correlations from several distributions of correlated noise sources including point sources that are exact time-lagged repeats of each other and Gaussian-distributed in space and time with covariance that exponentially decays. Assuming the noise distribution stays stationary over time, the artifacts become more coherent as more ambient noise is included in the Green's function estimates. We support our results with simple computational models. We observed these artifacts in Green's function estimates from a 2015 ambient noise study in Fairbanks, AK where a trenched distributed acoustic sensing (DAS) array was deployed to collect ambient noise alongside a road with the goal of developing a permafrost thaw monitoring system. We found that joints in the road repeatedly being hit by cars travelling at roughly the speed limit led to artifacts similar to those expected when several points are time-lagged copies of each other. We also show test results of attenuating the effects of these sources during time-lapse monitoring of an active thaw test in the same location with noise detected by a 2D trenched DAS array.

Relationship between regional myocardial blood flow and thallium-201 distribution in the presence of coronary artery stenosis and dipyridamole-induced vasodilation.

PubMed Central

Mays, A E; Cobb, F R

1984-01-01

This study assesses the relationship between the distribution of thallium-201 and myocardial blood flow during coronary vasodilation induced by intravenous dipyridamole in canine models of partial and complete coronary artery stenosis. 10 dogs were chronically instrumented with catheters in the left atrium and aorta and with a balloon occluder and electromagnetic flow probe on the proximal left circumflex coronary artery. Regional myocardial blood flow was measured during control conditions with radioisotope-labeled microspheres, and the phasic reactive hyperemic response to a 20-s transient occlusion was then recorded. Dipyridamole was then infused intravenously until phasic coronary blood flow increased to match peak hyperemic values. The left circumflex coronary artery was either partially occluded to reduce phasic blood flow to control values (group 1) or it was completely occluded (group 2), and thallium-201 and a second microsphere label were injected. 5 min later, the animals were sacrificed, the left ventricle was sectioned into 1-2-g samples, and thallium-201 activity and regional myocardial blood flow were measured. Curvilinear regression analyses between thallium-201 localization and myocardial blood flow during dipyridamole infusion demonstrated a slightly better fit to a second- as compared with a first-order model, indicating a slight roll-off of thallium activity as myocardial blood flow increases. During the dipyridamole infusion, the increases in phasic blood flow, the distributions of regional myocardial blood flow, and the relationships between thallium-201 localization and regional blood flow were comparable to values previously observed in exercising dogs with similar occlusions. These data provide basic validation that supports the use of intravenous dipyridamole and thallium-201 as an alternative to exercise stress and thallium-201 for evaluating the effects of coronary occlusive lesions on the distribution of regional myocardial blood flow. PMID:6715540

Heart Rate and Blood Pressure Centile Curves and Distributions by Age of Hospitalized Critically Ill Children.

PubMed

Eytan, Danny; Goodwin, Andrew J; Greer, Robert; Guerguerian, Anne-Marie; Laussen, Peter C

2017-01-01

Heart rate (HR) and blood pressure (BP) form the basis for monitoring the physiological state of patients. Although norms have been published for healthy and hospitalized children, little is known about their distributions in critically ill children. The objective of this study was to report the distributions of these basic physiological variables in hospitalized critically ill children. Continuous data from bedside monitors were collected and stored at 5-s intervals from 3,677 subjects aged 0-18 years admitted over a period of 30 months to the pediatric and cardiac intensive care units at a large quaternary children's hospital. Approximately 1.13 billion values served to estimate age-specific distributions for these two basic physiological variables: HR and intra-arterial BP. Centile curves were derived from the sample distributions and compared to common reference ranges. Properties such as kurtosis and skewness of these distributions are described. In comparison to previously published reference ranges, we show that children in these settings exhibit markedly higher HRs than their healthy counterparts or children hospitalized on in-patient wards. We also compared commonly used published estimates of hypotension in children (e.g., the PALS guidelines) to the values we derived from critically ill children. This is a first study reporting the distributions of basic physiological variables in children in the pediatric intensive care settings, and the percentiles derived may serve as useful references for bedside clinicians and clinical trials.

Lognormal Approximations of Fault Tree Uncertainty Distributions.

PubMed

El-Shanawany, Ashraf Ben; Ardron, Keith H; Walker, Simon P

2018-01-26

Fault trees are used in reliability modeling to create logical models of fault combinations that can lead to undesirable events. The output of a fault tree analysis (the top event probability) is expressed in terms of the failure probabilities of basic events that are input to the model. Typically, the basic event probabilities are not known exactly, but are modeled as probability distributions: therefore, the top event probability is also represented as an uncertainty distribution. Monte Carlo methods are generally used for evaluating the uncertainty distribution, but such calculations are computationally intensive and do not readily reveal the dominant contributors to the uncertainty. In this article, a closed-form approximation for the fault tree top event uncertainty distribution is developed, which is applicable when the uncertainties in the basic events of the model are lognormally distributed. The results of the approximate method are compared with results from two sampling-based methods: namely, the Monte Carlo method and the Wilks method based on order statistics. It is shown that the closed-form expression can provide a reasonable approximation to results obtained by Monte Carlo sampling, without incurring the computational expense. The Wilks method is found to be a useful means of providing an upper bound for the percentiles of the uncertainty distribution while being computationally inexpensive compared with full Monte Carlo sampling. The lognormal approximation method and Wilks's method appear attractive, practical alternatives for the evaluation of uncertainty in the output of fault trees and similar multilinear models. © 2018 Society for Risk Analysis.

Bilingual Adult Basic Education Project. Final Report.

ERIC Educational Resources Information Center

Graham, Janet Roth

The Bilingual Adult Basic Education Project provided bilingual life skills instruction, counseling, and informational services to approximately 150 non-English-dominant adults across Pennsylvania by means of contracts to local education agencies. Students were pre- and post-tested in English and/or their native language to measure their growth in…

On Basic Needs and Modest Media.

ERIC Educational Resources Information Center

Gunter, Jock

1978-01-01

The need for grass-roots participation and local control in whatever technology is used to meet basic educational needs is stressed. Successful uses of the audio cassette recorder and the portable half-inch video recorder are described; the 8-mm sound camera and video player are also suggested as viable "modest" technologies. (JEG)

Sustainable Table | Welcome to Sustainable Table

Science.gov Websites

celebrates local, sustainable food, educates consumers about the benefits of sustainable agriculture and agriculture from the basics to key issues in depth. Eating Sustainably Find out how to shop for and prepare educate others to help build a sustainable food future! In Focus Sustainable Agriculture - The Basics

47 CFR 69.157 - Line port costs in excess of basic, analog service.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Line port costs in excess of basic, analog service. 69.157 Section 69.157 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) ACCESS CHARGES Computation of Charges for Price Cap Local Exchange Carriers...

Tax Wealth in Fifty States. 1977 Supplement.

ERIC Educational Resources Information Center

Halstead, D. Kent; Weldon, H. Kent

This first supplement to the basic volume presents tax capacity, effort, and collected revenue data for state and local governments for 1977. Planned for issuance every other year, the supplement consists of computer printout tables with the earlier basic volume continuing to serve as reference for theory, analysis, and methodology. Figures for…

KANSAS STATE PLAN FOR ADULT BASIC EDUCATION.

ERIC Educational Resources Information Center

Kansas State Dept. of Public Instruction, Topeka.

THE KANSAS PLAN IS DESIGNED TO HELP ESTABLISH NEW LOCAL ADULT BASIC EDUCATION PROGRAMS, AND TO EXPAND AND IMPROVE EXISTING ONES. INSTRUCTIONAL CONTENT WILL INCLUDE READING AND WRITING, SPEAKING AND LISTENING SKILLS, CITIZENSHIP, CONSUMER EDUCATION, HUMAN RELATIONS, AND FAMILY LIFE EDUCATION. EARLY STAGES OF PLANNING (TO JUNE 30, 1966) WILL STRESS…

On the Development of Schools' External Public Relations in China.

ERIC Educational Resources Information Center

Tianping, Yang

2003-01-01

Public relations is a basic function of a modern school's management, while external public relationship is a basic principle and component of it. To develop a school's public relationship, efforts should focus on its key publics, strengthening its coordination and communication with governments, education departments, and local communities.…

An Architecture for Controlling Multiple Robots

NASA Technical Reports Server (NTRS)

Aghazarian, Hrand; Pirjanian, Paolo; Schenker, Paul; Huntsberger, Terrance

2004-01-01

The Control Architecture for Multirobot Outpost (CAMPOUT) is a distributed-control architecture for coordinating the activities of multiple robots. In the CAMPOUT, multiple-agent activities and sensor-based controls are derived as group compositions and involve coordination of more basic controllers denoted, for present purposes, as behaviors. The CAMPOUT provides basic mechanistic concepts for representation and execution of distributed group activities. One considers a network of nodes that comprise behaviors (self-contained controllers) augmented with hyper-links, which are used to exchange information between the nodes to achieve coordinated activities. Group behavior is guided by a scripted plan, which encodes a conditional sequence of single-agent activities. Thus, higher-level functionality is composed by coordination of more basic behaviors under the downward task decomposition of a multi-agent planner

Combining local scaling and global methods to detect soil pore space

NASA Astrophysics Data System (ADS)

Martin-Sotoca, Juan Jose; Saa-Requejo, Antonio; Grau, Juan B.; Tarquis, Ana M.

2017-04-01

The characterization of the spatial distribution of soil pore structures is essential to obtain different parameters that will influence in several models related to water flow and/or microbial growth processes. The first step in pore structure characterization is obtaining soil images that best approximate reality. Over the last decade, major technological advances in X-ray computed tomography (CT) have allowed for the investigation and reconstruction of natural porous media architectures at very fine scales. The subsequent step is delimiting the pore structure (pore space) from the CT soil images applying a thresholding. Many times we could find CT-scan images that show low contrast at the solid-void interface that difficult this step. Different delimitation methods can result in different spatial distributions of pores influencing the parameters used in the models. Recently, new local segmentation method using local greyscale value (GV) concentration variabilities, based on fractal concepts, has been presented. This method creates singularity maps to measure the GV concentration at each point. The C-A method was combined with the singularity map approach (Singularity-CA method) to define local thresholds that can be applied to binarize CT images. Comparing this method with classical methods, such as Otsu and Maximum Entropy, we observed that more pores can be detected mainly due to its ability to amplify anomalous concentrations. However, it delineated many small pores that were incorrect. In this work, we present an improve version of Singularity-CA method that avoid this problem basically combining it with the global classical methods. References Martín-Sotoca, J.J., A. Saa-Requejo, J.B. Grau, A.M. Tarquis. New segmentation method based on fractal properties using singularity maps. Geoderma, 287, 40-53, 2017. Martín-Sotoca, J.J, A. Saa-Requejo, J.B. Grau, A.M. Tarquis. Local 3D segmentation of soil pore space based on fractal properties using singularity maps. Geoderma, http://dx.doi.org/10.1016/j.geoderma.2016.11.029. Torre, Iván G., Juan C. Losada and A.M. Tarquis. Multiscaling properties of soil images. Biosystems Engineering, http://dx.doi.org/10.1016/j.biosystemseng.2016.11.006.

Antibiotic resistance genes across a wide variety of metagenomes.

PubMed

Fitzpatrick, David; Walsh, Fiona

2016-02-01

The distribution of potential clinically relevant antibiotic resistance (AR) genes across soil, water, animal, plant and human microbiomes is not well understood. We aimed to investigate if there were differences in the distribution and relative abundances of resistance genes across a variety of ecological niches. All sequence reads (human, animal, water, soil, plant and insect metagenomes) from the MG-RAST database were downloaded and assembled into a local sequence database. We show that there are many reservoirs of the basic form of resistance genes e.g. blaTEM, but the human and mammalian gut microbiomes contain the widest diversity of clinically relevant resistance genes using metagenomic analysis. The human microbiomes contained a high relative abundance of resistance genes, while the relative abundances varied greatly in the marine and soil metagenomes, when datasets with greater than one million genes were compared. While these results reflect a bias in the distribution of AR genes across the metagenomes, we note this interpretation with caution. Metagenomics analysis includes limits in terms of detection and identification of AR genes in complex and diverse microbiome population. Therefore, if we do not detect the AR gene is it in fact not there or just below the limits of our techniques? © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Identical metabolic rate and thermal conductance in Rock Sandpiper (Calidris ptilocnemis) subspecies with contrasting nonbreeding life histories

USGS Publications Warehouse

Ruthrauff, Daniel R.; Dekinga, Anne; Gill, Robert E.; Piersma, Theunis

2013-01-01

Closely related species or subspecies can exhibit metabolic differences that reflect site-specific environmental conditions. Whether such differences represent fixed traits or flexible adjustments to local conditions, however, is difficult to predict across taxa. The nominate race of Rock Sandpiper (Calidris ptilocnemis) exhibits the most northerly nonbreeding distribution of any shorebird in the North Pacific, being common during winter in cold, dark locations as far north as upper Cook Inlet, Alaska (61°N). By contrast, the tschuktschorum subspecies migrates to sites ranging from about 59°N to more benign locations as far south as ~37°N. These distributional extremes exert contrasting energetic demands, and we measured common metabolic parameters in the two subspecies held under identical laboratory conditions to determine whether differences in these parameters are reflected by their nonbreeding life histories. Basal metabolic rate and thermal conductance did not differ between subspecies, and the subspecies had a similar metabolic response to temperatures below their thermoneutral zone. Relatively low thermal conductance values may, however, reflect intrinsic metabolic adaptations to northerly latitudes. In the absence of differences in basic metabolic parameters, the two subspecies’ nonbreeding distributions will likely be more strongly influenced by adaptations to regional variation in ecological factors such as prey density, prey quality, and foraging habitat.

Pharmaceutical policies for the Third World--whose responsibility?

PubMed

1983-07-16

Several developing countries, such as Bangladesh, Cuba, India, and Mozambique, are currently formulating national pharmaceutical policies to reduce expenditures on drugs while increasing their availability to those in greatest need. 5 components of such national policies have been identified: 1) elimination of ineffective and inappropriate preparations through concentrating on a selection such as the World Health Organization's 200 "basic and essential drugs", coupled with national drug pricing policies that discriminate between essential drugs and non-essential or luxury drugs; 2) public systems of drug distribution which would reduce costs to the consumer; 3) importation of the limited number of drugs distributed through the public system in bulk, which might reduce costs by 20-25%; 4) use of generic rather than brand name drugs; and 5) establishment of domestic pharmaceutical industries within developing countries to encourage research into drugs for local health problems, reduce use of foreign exchange to import drugs, and increase local self-reliance in dealing with disease. In November 1982, Health Action International, a coordinating body for more than 50 publish interest groups seeking to promote rational use of pharmaceuticals, presented a draft internationl code on pharmaceuticals to the UN Conference on Trade and Development. A voluntary code produced in 1981 by the International Federation of Pharmaceutical Manufacturers' Associations paid little attention to monitoring and enforcement. Little progress has been made, and the need for sensible policy making at the international and national levels has long been apparent.

Effect of Cracow program elimination of low emission sources upon the energy management system in Cracow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedberg, J.; Goerlich, K.; Glowacki, K.

1995-12-31

At the end of the 1980s, the energy management at the local level-like the whole set of such utility services-was based upon respective enterprises subject to a certain supervision of the establishing body and to a control of the District Inspectorate of Energy Management. Those enterprises that deal with generation and supply of heat energy to the local market, with distribution of heat, natural gas and electricity, operated as state companies; the last two branches made a part of either regional or national companies. Irrespective of the aforesaid, the co-generation power plants existed usually outside the heat generation and supplymore » system. The business economics of these enterprises was not subject to any market rules whatsoever, the prices were controlled and the customers had no right of choice of the energy supplier. From the very beginning the low emission elimination program assumed to have commercial rules introduced in the energy management. Thus, it turned out necessary to prepare the market - to draw up inventory of the conditions and needs related with heat supply and to take up market solutions as well. The management system, and in particular the items specified below, is discussed. The co-operation of energy distribution enterprises has been based upon a voluntary agreement (The Team for Energy Suppliers) so as to agree upon the basic actions of the respective partners; joint actions have been taken up more and more willingly.« less

Immunocytochemical localization of three vesicular glutamate transporters in the cat retina.

PubMed

Fyk-Kolodziej, Bozena; Dzhagaryan, Arturik; Qin, Pu; Pourcho, Roberta G

2004-08-02

Vesicular transporters play an essential role in the packaging of glutamate for synaptic release and so are of particular importance in the retina, where glutamate serves as the neurotransmitter for photoreceptors, bipolar cells, and ganglion cells. In the present study, we have examined the distribution of the three known isoforms of vesicular glutamate transporter (VGLUT) in the cat retina. VGLUT1 was localized to all photoreceptor and bipolar cells, whereas VGLUT2 was found in ganglion cells. This basic pattern of complementary distribution for the two transporters among known populations of glutamatergic cells is similar to previous findings in the brain and spinal cord. However, the axon terminals of S-cone photoreceptors were found to express both VGLUT1 and VGLUT2 and some ganglion cells labeled for both VGLUT2 and VGLUT3. Such colocalizations suggest the existence of dual modes of regulation of vesicular glutamate transport in these neurons. Staining for VGLUT2 was also present in a small number of varicose processes, which were seen to ramify throughout the inner plexiform layer. These fibers may represent axon collaterals of ganglion cells. The most prominent site of VGLUT3 immunoreactivity was in a population of amacrine cells; the axon terminals of B-type horizontal cells were also labeled at their contacts with rod spherules. The presence of the VGLUT3 transporter at sites not otherwise implicated in glutamate release may indicate novel modes of glutamate signaling or additional roles for the transporter molecule. Copyright 2004 Wiley-Liss, Inc.

Generation of a dynamo magnetic field in a protoplanetary accretion disk

NASA Technical Reports Server (NTRS)

Stepinski, T.; Levy, E. H.

1987-01-01

A new computational technique is developed that allows realistic calculations of dynamo magnetic field generation in disk geometries corresponding to protoplanetary and protostellar accretion disks. The approach is of sufficient generality to allow, in the future, a wide class of accretion disk problems to be solved. Here, basic modes of a disk dynamo are calculated. Spatially localized oscillatory states are found to occur in Keplerain disks. A physical interpretation is given that argues that spatially localized fields of the type found in these calculations constitute the basic modes of a Keplerian disk dynamo.

Groundwater and Distribution Workbook.

ERIC Educational Resources Information Center

Ekman, John E.

Presented is a student manual designed for the Wisconsin Vocational, Technical and Adult Education Groundwater and Distribution Training Course. This program introduces waterworks operators-in-training to basic skills and knowledge required for the operation of a groundwater distribution waterworks facility. Arranged according to the general order…

Expansion moments for the local field distribution that involve the three-particle distribution function

NASA Astrophysics Data System (ADS)

Attard, Phil

The second moment of the Lennard-Jones local field distribution in a hard-sphere fluid is evaluated using the PY3 three-particle distribution function. An approximation due to Lado that avoids the explicit calculation of the latter is shown to be accurate. Partial results are also given for certain cavity-hard-sphere radial distribution functions that occur in a closest particle expansion for the local field.

Combined effect of CVR and penetration of DG in the voltage profile and losses of lowvoltage secondary distribution networks

NASA Astrophysics Data System (ADS)

Bokhari, Abdullah

Demarcations between traditional distribution power systems and distributed generation (DG) architectures are increasingly evolving as higher DG penetration is introduced in the system. The concerns in existing electric power systems (EPSs) to accommodate less restrictive interconnection policies while maintaining reliability and performance of power delivery have been the major challenge for DG growth. In this dissertation, the work is aimed to study power quality, energy saving and losses in a low voltage distributed network under various DG penetration cases. Simulation platform suite that includes electric power system, distributed generation and ZIP load models is implemented to determine the impact of DGs on power system steady state performance and the voltage profile of the customers/loads in the network under the voltage reduction events. The investigation designed to test the DG impact on power system starting with one type of DG, then moves on multiple DG types distributed in a random case and realistic/balanced case. The functionality of the proposed DG interconnection is designed to meet the basic requirements imposed by the various interconnection standards, most notably IEEE 1547, public service commission, and local utility regulation. It is found that implementation of DGs on the low voltage secondary network would improve customer's voltage profile, system losses and significantly provide energy savings and economics for utilities. In a network populated with DGs, utility would have a uniform voltage profile at the customers end as the voltage profile becomes more concentrated around targeted voltage level. The study further reinforced the concept that the behavior of DG in distributed network would improve voltage regulation as certain percentage reduction on utility side would ensure uniform percentage reduction seen by all customers and reduce number of voltage violations.

[Implementation of the International Health Regulations in Cuba: evaluation of basic capacities of the health sector in selected provinces].

PubMed

Gala, Ángela; Toledo, María Eugenia; Arias, Yanisnubia; Díaz González, Manuel; Alvarez Valdez, Angel Manuel; Estévez, Gonzalo; Abreu, Rolando Miyar; Flores, Gustavo Kourí

2012-09-01

Obtain baseline information on the status of the basic capacities of the health sector at the local, municipal, and provincial levels in order to facilitate identification of priorities and guide public policies that aim to comply with the requirements and capacities established in Annex 1A of the International Health Regulations 2005 (IHR-2005). A descriptive cross-sectional study was conducted by application of an instrument of evaluation of basic capacities referring to legal and institutional autonomy, the surveillance and research process, and the response to health emergencies in 36 entities involved in international sanitary control at the local, municipal, and provincial levels in the provinces of Havana, Cienfuegos, and Santiago de Cuba. The polyclinics and provincial centers of health and epidemiology in the three provinces had more than 75% of the basic capacities required. Twelve out of 36 units had implemented 50% of the legal and institutional framework. There was variable availability of routine surveillance and research, whereas the entities in Havana had more than 40% of the basic capacities in the area of events response. The provinces evaluated have integrated the basic capacities that will allow implementation of IHR-2005 within the period established by the World Health Organization. It is necessary to develop and establish effective action plans to consolidate surveillance as an essential activity of national and international security in terms of public health.

The Records Management Officer in Local Government. Basic Records Management for Local Government, No. 2.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. State Archives and Records Administration.

This reports provides local governments with guidelines and suggestions for selecting a Records Management Officer to develop, organize, and direct a records management program. Such a program is described as an over-arching, continuing, administrative effort that manages recorded information from its initial creation to its final disposition.…

A Case Study of Local Needs for Information on Industrial Development. Extension Studies 55.

ERIC Educational Resources Information Center

Fuller, Theodore E.; Turner, Francis C.

In order to identify some basic types of information concerning industrial development which might be useful to decision-makers at the local level, an opinion survey was conducted in five bordering nonmetropolitan Pennsylvania counties. A 13-item questionnaire was mailed to 222 local organizations, categorized by response rate as follows: (1)…

34 CFR 403.195 - What are the administrative cost requirements applicable to local recipients?

Code of Federal Regulations, 2010 CFR

2010-07-01

... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAM What Conditions Must be Met by Local Recipients? § 403... educational agency, that receives an award under a basic program listed in § 403.60 or a special program...

Energy System Basics and Distribution Integration Video Series | Energy

Science.gov Websites

renewablesparticularly solar photovoltaic (PV) technologiesonto the distribution grid. Solar Energy Technologies PV Integration Case Studies Integrating Photovoltaic Systems onto Secondary Network Distribution Systems Standards and Codes for U.S. Photovoltaic System Installation Network-Optimal Control of Photovoltaics on

The Space Weather Monitor Project: Bringing Hands-on Science to Students of the Developing World for the IHY2007

NASA Astrophysics Data System (ADS)

Scherrer, D. K.; Rabello-Soares, M. C.; Morrow, C.

2006-08-01

Stanford's Solar Center, Electrical Engineering Department, and local educators have developed inexpensive Space Weather Monitors that students around the world can use to track solar-induced changes to the Earth's ionosphere. Through the United Nations Basic Space Science Initiative (UNBSSI) and the IHY Education and Public Outreach Program, our Monitors are being deployed to 191 countries for the International Heliophysical Year, 2007. In partnership with Chabot Space and Science Center, we are designing and developing classroom and educator support materials to accompany the distribution. Materials will be culturally sensitive and will be translated into the six official languages of the United Nations (Arabic, Chinese, English, French, Russian, and Spanish). Monitors will be provided free of charge to developing nations and can be set up anywhere there is access to power.

The structure and function of the dopamine transporter and its role in CNS diseases.

PubMed

McHugh, Patrick C; Buckley, David A

2015-01-01

In this chapter, we explore the basic science of the dopamine transporter (DAT), an integral component of a system that regulates dopamine homeostasis. Dopamine is a key neurotransmitter for several brain functions including locomotor control and reward systems. The transporter structure, function, mechanism of action, localization, and distribution, in addition to gene regulation, are discussed. Over many years, a wealth of information concerning the DAT has been accrued and has led to increased interest in the role of the DAT in a plethora of central nervous system diseases. These DAT characteristics are explored in relation to a range of neurological and neuropsychiatric diseases, with a particular focus on the genetics of the DAT. In addition, we discuss the pharmacology of the DAT and how this relates to disease and addiction. © 2015 Elsevier Inc. All rights reserved.

Hit rates and radiation doses to nuclei of bone lining cells from alpha-particle-emitting radionuclides

NASA Technical Reports Server (NTRS)

Polig, E.; Jee, W. S.; Kruglikov, I. L.

1992-01-01

Factors relating the local concentration of a bone-seeking alpha-particle emitter to the mean hit rate have been determined for nuclei of bone lining cells using a Monte Carlo procedure. Cell nuclei were approximated by oblate spheroids with dimensions and location taken from a previous histomorphometric study. The Monte Carlo simulation is applicable for planar and diffuse labels at plane or cylindrical bone surfaces. Additionally, the mean nuclear dose per hit, the dose mean per hit, the mean track segment length and its second moment, the percentage of stoppers, and the frequency distribution of the dose have been determined. Some basic features of the hit statistics for bone lining cells have been outlined, and the consequences of existing standards of radiation protection with regard to the hit frequency to cell nuclei are discussed.

BioContainers: an open-source and community-driven framework for software standardization.

PubMed

da Veiga Leprevost, Felipe; Grüning, Björn A; Alves Aflitos, Saulo; Röst, Hannes L; Uszkoreit, Julian; Barsnes, Harald; Vaudel, Marc; Moreno, Pablo; Gatto, Laurent; Weber, Jonas; Bai, Mingze; Jimenez, Rafael C; Sachsenberg, Timo; Pfeuffer, Julianus; Vera Alvarez, Roberto; Griss, Johannes; Nesvizhskii, Alexey I; Perez-Riverol, Yasset

2017-08-15

BioContainers (biocontainers.pro) is an open-source and community-driven framework which provides platform independent executable environments for bioinformatics software. BioContainers allows labs of all sizes to easily install bioinformatics software, maintain multiple versions of the same software and combine tools into powerful analysis pipelines. BioContainers is based on popular open-source projects Docker and rkt frameworks, that allow software to be installed and executed under an isolated and controlled environment. Also, it provides infrastructure and basic guidelines to create, manage and distribute bioinformatics containers with a special focus on omics technologies. These containers can be integrated into more comprehensive bioinformatics pipelines and different architectures (local desktop, cloud environments or HPC clusters). The software is freely available at github.com/BioContainers/. yperez@ebi.ac.uk. © The Author(s) 2017. Published by Oxford University Press.

BioContainers: an open-source and community-driven framework for software standardization

PubMed Central

da Veiga Leprevost, Felipe; Grüning, Björn A.; Alves Aflitos, Saulo; Röst, Hannes L.; Uszkoreit, Julian; Barsnes, Harald; Vaudel, Marc; Moreno, Pablo; Gatto, Laurent; Weber, Jonas; Bai, Mingze; Jimenez, Rafael C.; Sachsenberg, Timo; Pfeuffer, Julianus; Vera Alvarez, Roberto; Griss, Johannes; Nesvizhskii, Alexey I.; Perez-Riverol, Yasset

2017-01-01

Abstract Motivation BioContainers (biocontainers.pro) is an open-source and community-driven framework which provides platform independent executable environments for bioinformatics software. BioContainers allows labs of all sizes to easily install bioinformatics software, maintain multiple versions of the same software and combine tools into powerful analysis pipelines. BioContainers is based on popular open-source projects Docker and rkt frameworks, that allow software to be installed and executed under an isolated and controlled environment. Also, it provides infrastructure and basic guidelines to create, manage and distribute bioinformatics containers with a special focus on omics technologies. These containers can be integrated into more comprehensive bioinformatics pipelines and different architectures (local desktop, cloud environments or HPC clusters). Availability and Implementation The software is freely available at github.com/BioContainers/. Contact yperez@ebi.ac.uk PMID:28379341

Attitudes and values of Peruvian coca growers.

PubMed

Rojas, Maritza R

2002-01-01

This study uses semi-structured interviews to examine the attitudes and values of Peruvian coca growers toward coca leaf and cocaine basic paste (CBP) consumption and its distribution. The subjects of the study were 186 coca growers from Peruvian jungle valleys who are involved in illegal commercialization of coca leaf and cocaine paste production. Data collected in 1994 reveal that growers consider coca leaf to be a most profitable product and a unique opportunity to improve their quality of life. Although growers acknowledge that a problem exists among local users, they do not assume any responsibility for CBP consumption and dissemination in rural areas. This leads to the conclusion that awareness of a CBP consumption problem is not enough for growers to stop drug production; they need consistent training in social values, as well as support in legal and economic alternatives.

The high speed interconnect system architecture and operation

NASA Astrophysics Data System (ADS)

Anderson, Steven C.

The design and operation of a fiber-optic high-speed interconnect system (HSIS) being developed to meet the requirements of future avionics and flight-control hardware with distributed-system architectures are discussed. The HSIS is intended for 100-Mb/s operation of a local-area network with up to 256 stations. It comprises a bus transmission system (passive star couplers and linear media linked by active elements) and network interface units (NIUs). Each NIU is designed to perform the physical, data link, network, and transport functions defined by the ISO OSI Basic Reference Model (1982 and 1983) and incorporates a fiber-optic transceiver, a high-speed protocol based on the SAE AE-9B linear token-passing data bus (1986), and a specialized application interface unit. The operating modes and capabilities of HSIS are described in detail and illustrated with diagrams.

Achieving food security in times of crisis.

PubMed

Swaminathan, M S

2010-11-30

In spite of several World Food Summits during the past decade, the number of people going to bed hungry is increasing and now exceeds one billion. Food security strategies should therefore be revisited. Food security systems should begin with local communities who can develop and manage community gene, seed, grain and water banks. At the national level, access to balanced diet and clean drinking water should become a basic human right. Implementation of the right to food will involve concurrent attention to production, procurement, preservation and public distribution. Higher production in perpetuity should be achieved through an ever-green revolution based on the principles of conservation and climate-resilient farming. This will call for a blend of traditional ecological prudence with frontier technologies, particularly biotechnology and information communication technologies. Copyright © 2010. Published by Elsevier B.V.

An analog neural hardware implementation using charge-injection multipliers and neutron-specific gain control.

PubMed

Massengill, L W; Mundie, D B

1992-01-01

A neural network IC based on a dynamic charge injection is described. The hardware design is space and power efficient, and achieves massive parallelism of analog inner products via charge-based multipliers and spatially distributed summing buses. Basic synaptic cells are constructed of exponential pulse-decay modulation (EPDM) dynamic injection multipliers operating sequentially on propagating signal vectors and locally stored analog weights. Individually adjustable gain controls on each neutron reduce the effects of limited weight dynamic range. A hardware simulator/trainer has been developed which incorporates the physical (nonideal) characteristics of actual circuit components into the training process, thus absorbing nonlinearities and parametric deviations into the macroscopic performance of the network. Results show that charge-based techniques may achieve a high degree of neural density and throughput using standard CMOS processes.

[Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet].

PubMed

Feng, Yu; Gao, Yue-Ping

2014-05-01

Polycystic ovary syndrome (PCOS) is one of the most popular diseases in obstetrics and gynecology research at internal and abroad at present, traditional Chinese medicine(TCM)in the clinical treatment of the disease have the advantage. Clinical epidemiological study of descriptive research method this research adopts investigation, observation of TCM syndromes and improper diet through 401 cases in Jiangsu Province confirmed PCOS patients, to explore the relationship between TCM syndrome type distribution and improper diet factors, and to provide the clinical basis for further etiology of this disease research. TCM syndrome type distribution of the disease is kidney deficiency, phlegm stagnation syndrome, qi stagnation and blood stasis syndrome, syndrome of dampness heat of liver channel and is composed of 4 basic syndromes and formed complex syndrome, and the composite and syndrome type (60.85%); combined with the analysis of traditional Chinese medicine dialectical, Pure empirical syndrome this disease (46.88%), followed by the actual card (45.39%), pure deficiency is rare. Improper diet factors associated with the disease, in which improper diet with different TCM syndrome type distribution significantly related. Stagnation of phlegm dampness syndrome is the main syndrome of the disease type, improper diet factors and every syndrome PCOS type distribution is as follows: the partial eclipse fatness greasy with basic syndromes of phlegm dampness stagnation of kidney deficiency syndrome, the nephrasthenia syndrome is less; eating spicy stimulation by basic syndromes of stagnation of Qi and blood stasis; eating cold people the basic certificate type of qi stagnation and blood stasis; The diet of patients are more prone to stagnation of phlegm dampness syndrome.

The Connection between Employee Basic Skills & Productivity. Workforce & Workplace Literacy Series.

ERIC Educational Resources Information Center

BCEL Brief, 1993

1993-01-01

The experience of a number of specific local workplace programs indicates a definite connection between the provision of employee basic skills programs and increased worker productivity. One Tennessee company, for example, reports a 95 percent drop in costs resulting from worker mistakes and a doubling of worker productivity since the company…

Analyzing Public Sector Education Facilities: A Step Further towards Accessible Basic Education Institutions in Destitute Subregions

ERIC Educational Resources Information Center

Talpur, Mir Aftab Hussain; Napiah, Madzlan; Chandio, Imtiaz Ahmed; Memon, Irfan Ahmed

2014-01-01

Rural subregions of the developing countries are suffering from many physical and socioeconomic problems, including scarcity of basic education institutions. The shortage of education institutions extended distance between rural localities and education institutions. Hence, to curb this problem, this research is aimed to deal with the basic…

75 FR 3163 - Vocational Rehabilitation and Employment Program-Basic Entitlement; Effective Date of Induction...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-20

... implemented changes to services provided under 38 U.S.C. chapter 31, which resulted from a court decision and..., for vocational rehabilitation basic entitlement determinations resulting from the Veterans' Benefits... issuing any rule that may result in the expenditure by State, local, and Tribal governments, in the...

5 CFR 531.206 - Order of processing simultaneous pay actions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... REGULATIONS PAY UNDER THE GENERAL SCHEDULE Determining Rate of Basic Pay General Provisions § 531.206 Order of... employee's rate of basic pay, the actions will be processed in the following order: (a) Process general pay... base rates; an adjustment of a locality pay percentage under subpart F of this part; the establishment...

10 CFR 429.12 - General requirements applicable to certification reports.

Code of Federal Regulations, 2012 CFR

2012-01-01

... distribution transformers, the basic model number or kVA grouping model number (depending on the certification... signal modules, Pedestrian modules, and Distribution transformers June 1. Room air conditioners... within one year after the first date of new model manufacture. (3) For distribution transformers, the...

10 CFR 429.12 - General requirements applicable to certification reports.

Code of Federal Regulations, 2013 CFR

2013-01-01

... distribution transformers, the basic model number or kVA grouping model number (depending on the certification... signal modules, Pedestrian modules, and Distribution transformers June 1. Room air conditioners... within one year after the first date of new model manufacture. (3) For distribution transformers, the...

Distributed Network and Multiprocessing Minicomputer State-of-the-Art Capabilities.

ERIC Educational Resources Information Center

Theis, Douglas J.

An examination of the capabilities of minicomputers and midicomputers now on the market reveals two basic items which users should evaluate when selecting computers for their own applications: distributed networking systems and multiprocessing architectures. Variables which should be considered in evaluating a distributed networking system…

Unified control/structure design and modeling research

NASA Technical Reports Server (NTRS)

Mingori, D. L.; Gibson, J. S.; Blelloch, P. A.; Adamian, A.

1986-01-01

To demonstrate the applicability of the control theory for distributed systems to large flexible space structures, research was focused on a model of a space antenna which consists of a rigid hub, flexible ribs, and a mesh reflecting surface. The space antenna model used is discussed along with the finite element approximation of the distributed model. The basic control problem is to design an optimal or near-optimal compensator to suppress the linear vibrations and rigid-body displacements of the structure. The application of an infinite dimensional Linear Quadratic Gaussian (LQG) control theory to flexible structure is discussed. Two basic approaches for robustness enhancement were investigated: loop transfer recovery and sensitivity optimization. A third approach synthesized from elements of these two basic approaches is currently under development. The control driven finite element approximation of flexible structures is discussed. Three sets of finite element basic vectors for computing functional control gains are compared. The possibility of constructing a finite element scheme to approximate the infinite dimensional Hamiltonian system directly, instead of indirectly is discussed.

Structure and function of yeast glutaredoxin 2 depend on postranslational processing and are related to subcellular distribution.

PubMed

Porras, Pablo; McDonagh, Brian; Pedrajas, Jose Rafael; Bárcena, J Antonio; Padilla, C Alicia

2010-04-01

We have previously shown that glutaredoxin 2 (Grx2) from Saccharomyces cerevisiae localizes at 3 different subcellular compartments, cytosol, mitochondrial matrix and outer membrane, as the result of different postranslational processing of one single gene. Having set the mechanism responsible for this remarkable phenomenon, we have now aimed at defining whether this diversity of subcellular localizations correlates with differences in structure and function of the Grx2 isoforms. We have determined the N-terminal sequence of the soluble mitochondrial matrix Grx2 by mass spectrometry and have determined the exact cleavage site by Mitochondrial Processing Peptidase (MPP). As a consequence of this cleavage, the mitochondrial matrix Grx2 isoform possesses a basic tetrapeptide extension at the N-terminus compared to the cytosolic form. A functional relationship to this structural difference is that mitochondrial Grx2 displays a markedly higher activity in the catalysis of GSSG reduction by the mitochondrial dithiol dihydrolipoamide. We have prepared Grx2 mutants affected on key residues inside the presequence to direct the protein to one single cellular compartment; either the cytosol, the mitochondrial membrane or the matrix and have analyzed their functional phenotypes. Strains expressing Grx2 only in the cytosol are equally sensitive to H(2)O(2) as strains lacking the gene, whereas those expressing Grx2 exclusively in the mitochondrial matrix are more resistant. Mutations on key basic residues drastically affect the cellular fate of the protein, showing that evolutionary diversification of Grx2 structural and functional properties are strictly dependent on the sequence of the targeting signal peptide. Copyright 2009 Elsevier B.V. All rights reserved.

Assessing local structure motifs using order parameters for motif recognition, interstitial identification, and diffusion path characterization

NASA Astrophysics Data System (ADS)

Zimmermann, Nils E. R.; Horton, Matthew K.; Jain, Anubhav; Haranczyk, Maciej

2017-11-01

Structure-property relationships form the basis of many design rules in materials science, including synthesizability and long-term stability of catalysts, control of electrical and optoelectronic behavior in semiconductors as well as the capacity of and transport properties in cathode materials for rechargeable batteries. The immediate atomic environments (i.e., the first coordination shells) of a few atomic sites are often a key factor in achieving a desired property. Some of the most frequently encountered coordination patterns are tetrahedra, octahedra, body and face-centered cubic as well as hexagonal closed packed-like environments. Here, we showcase the usefulness of local order parameters to identify these basic structural motifs in inorganic solid materials by developing classification criteria. We introduce a systematic testing framework, the Einstein crystal test rig, that probes the response of order parameters to distortions in perfect motifs to validate our approach. Subsequently, we highlight three important application cases. First, we map basic crystal structure information of a large materials database in an intuitive manner by screening the Materials Project (MP) database (61,422 compounds) for element-specific motif distributions. Second, we use the structure-motif recognition capabilities to automatically find interstitials in metals, semiconductor, and insulator materials. Our Interstitialcy Finding Tool (InFiT) facilitates high-throughput screenings of defect properties. Third, the order parameters are reliable and compact quantitative structure descriptors for characterizing diffusion hops of intercalants as our example of magnesium in MnO2-spinel indicates. Finally, the tools developed in our work are readily and freely available as software implementations in the pymatgen library, and we expect them to be further applied to machine-learning approaches for emerging applications in materials science.

Assessing Local Structure Motifs Using Order Parameters for Motif Recognition, Interstitial Identification, and Diffusion Path Characterization

DOE PAGES

Zimmermann, Nils E. R.; Horton, Matthew K.; Jain, Anubhav; ...

2017-11-13

Structure–property relationships form the basis of many design rules in materials science, including synthesizability and long-term stability of catalysts, control of electrical and optoelectronic behavior in semiconductors, as well as the capacity of and transport properties in cathode materials for rechargeable batteries. The immediate atomic environments (i.e., the first coordination shells) of a few atomic sites are often a key factor in achieving a desired property. Some of the most frequently encountered coordination patterns are tetrahedra, octahedra, body and face-centered cubic as well as hexagonal close packed-like environments. Here, we showcase the usefulness of local order parameters to identify thesemore » basic structural motifs in inorganic solid materials by developing classification criteria. We introduce a systematic testing framework, the Einstein crystal test rig, that probes the response of order parameters to distortions in perfect motifs to validate our approach. Subsequently, we highlight three important application cases. First, we map basic crystal structure information of a large materials database in an intuitive manner by screening the Materials Project (MP) database (61,422 compounds) for element-specific motif distributions. Second, we use the structure-motif recognition capabilities to automatically find interstitials in metals, semiconductor, and insulator materials. Our Interstitialcy Finding Tool (InFiT) facilitates high-throughput screenings of defect properties. Third, the order parameters are reliable and compact quantitative structure descriptors for characterizing diffusion hops of intercalants as our example of magnesium in MnO 2-spinel indicates. Finally, the tools developed in our work are readily and freely available as software implementations in the pymatgen library, and we expect them to be further applied to machine-learning approaches for emerging applications in materials science.« less

Roles of Gag-RNA interactions in HIV-1 virus assembly deciphered by single-molecule localization microscopy.

PubMed

Yang, Yantao; Qu, Na; Tan, Jie; Rushdi, Muaz N; Krueger, Christopher J; Chen, Antony K

2018-06-11

During HIV-1 assembly, the retroviral structural protein Gag forms an immature capsid, containing thousands of Gag molecules, at the plasma membrane (PM). Interactions between Gag nucleocapsid (NC) and viral RNA (vRNA) are thought to drive assembly, but the exact roles of these interactions have remained poorly understood. Since previous studies have shown that Gag dimer- or trimer-forming mutants (Gag ZiL ) lacking an NC domain can form immature capsids independent of RNA binding, it is often hypothesized that vRNA drives Gag assembly by inducing Gag to form low-ordered multimers, but is dispensable for subsequent assembly. In this study, we examined the role of vRNA in HIV-1 assembly by characterizing the distribution and mobility of Gag and Gag NC mutants at the PM using photoactivated localization microscopy (PALM) and single-particle tracking PALM (spt-PALM). We showed that both Gag and Gag ZiL assembly involve a similar basic assembly unit, as expected. Unexpectedly, the two proteins underwent different subsequent assembly pathways, with Gag cluster density increasing asymptotically, while Gag ZiL cluster density increased linearly. Additionally, the directed movement of Gag, but not Gag ZiL , was maintained at a constant speed, suggesting that the two proteins experience different external driving forces. Assembly was abolished when Gag was rendered monomeric by NC deletion. Collectively, these results suggest that, beyond inducing Gag to form low-ordered multimer basic assembly units, vRNA is essential in scaffolding and maintaining the stability of the subsequent assembly process. This finding should advance the current understanding of HIV-1 and, potentially, other retroviruses. Copyright © 2018 the Author(s). Published by PNAS.

Assessing Local Structure Motifs Using Order Parameters for Motif Recognition, Interstitial Identification, and Diffusion Path Characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zimmermann, Nils E. R.; Horton, Matthew K.; Jain, Anubhav

Structure–property relationships form the basis of many design rules in materials science, including synthesizability and long-term stability of catalysts, control of electrical and optoelectronic behavior in semiconductors, as well as the capacity of and transport properties in cathode materials for rechargeable batteries. The immediate atomic environments (i.e., the first coordination shells) of a few atomic sites are often a key factor in achieving a desired property. Some of the most frequently encountered coordination patterns are tetrahedra, octahedra, body and face-centered cubic as well as hexagonal close packed-like environments. Here, we showcase the usefulness of local order parameters to identify thesemore » basic structural motifs in inorganic solid materials by developing classification criteria. We introduce a systematic testing framework, the Einstein crystal test rig, that probes the response of order parameters to distortions in perfect motifs to validate our approach. Subsequently, we highlight three important application cases. First, we map basic crystal structure information of a large materials database in an intuitive manner by screening the Materials Project (MP) database (61,422 compounds) for element-specific motif distributions. Second, we use the structure-motif recognition capabilities to automatically find interstitials in metals, semiconductor, and insulator materials. Our Interstitialcy Finding Tool (InFiT) facilitates high-throughput screenings of defect properties. Third, the order parameters are reliable and compact quantitative structure descriptors for characterizing diffusion hops of intercalants as our example of magnesium in MnO 2-spinel indicates. Finally, the tools developed in our work are readily and freely available as software implementations in the pymatgen library, and we expect them to be further applied to machine-learning approaches for emerging applications in materials science.« less

Cooperative Lander-Surface/Aerial Microflyer Missions for Mars Exploration

NASA Technical Reports Server (NTRS)

Thakoor, Sarita; Lay, Norman; Hine, Butler; Zornetzer, Steven

2004-01-01

Concepts are being investigated for exploratory missions to Mars based on Bioinspired Engineering of Exploration Systems (BEES), which is a guiding principle of this effort to develop biomorphic explorers. The novelty lies in the use of a robust telecom architecture for mission data return, utilizing multiple local relays (including the lander itself as a local relay and the explorers in the dual role of a local relay) to enable ranges 10 to 1,000 km and downlink of color imagery. As illustrated in Figure 1, multiple microflyers that can be both surface or aerially launched are envisioned in shepherding, metamorphic, and imaging roles. These microflyers imbibe key bio-inspired principles in their flight control, navigation, and visual search operations. Honey-bee inspired algorithms utilizing visual cues to perform autonomous navigation operations such as terrain following will be utilized. The instrument suite will consist of a panoramic imager and polarization imager specifically optimized to detect ice and water. For microflyers, particularly at small sizes, bio-inspired solutions appear to offer better alternate solutions than conventional engineered approaches. This investigation addresses a wide range of interrelated issues, including desired scientific data, sizes, rates, and communication ranges that can be accomplished in alternative mission scenarios. The mission illustrated in Figure 1 offers the most robust telecom architecture and the longest range for exploration with two landers being available as main local relays in addition to an ephemeral aerial probe local relay. The shepherding or metamorphic plane are in their dual role as local relays and image data collection/storage nodes. Appropriate placement of the landing site for the scout lander with respect to the main mission lander can allow coverage of extremely large ranges and enable exhaustive survey of the area of interest. In particular, this mission could help with the path planning and risk mitigation in the traverse of the long-distance surface explorer/rover. The basic requirements of design and operation of BEES to implement the scenarios are discussed. Terrestrial applications of such concepts include distributed aerial/surface measurements of meteorological events, i.e., storm watch, seismic monitoring, reconnaissance, biological chemical sensing, search and rescue, surveillance, autonomous security/ protection agents, and/or delivery and lateral distribution of agents (sensors, surface/subsurface crawlers, clean-up agents). Figure 2 illustrates an Earth demonstration that is in development, and its implementation will illustrate the value of these biomorphic mission concepts.

Networking CD-ROMs: The Decision Maker's Guide to Local Area Network Solutions.

ERIC Educational Resources Information Center

Elshami, Ahmed M.

In an era when patrons want access to CD-ROM resources but few libraries can afford to buy multiple copies, CD-ROM local area networks (LANs) are emerging as a cost-effective way to provide shared access. To help librarians make informed decisions, this manual offers information on: (1) the basics of LANs, a "local area network primer";…

Wood Residue Distribution Simulator (WORDS)

Treesearch

Douglas A. Eza; James W. McMinn; Peter E. Dress

1984-01-01

Successful development of woody biomass for energy will depend on the distribution of local supply and demand within subregions, rather than on the total inventory of residues. The Wood Residue Distribution Simulator (WORDS) attempts to find a least-cost allocation of residues from local sources of supply to local sources of demand, given the cost of the materials,...

Drude weight fluctuations in many-body localized systems

NASA Astrophysics Data System (ADS)

Filippone, Michele; Brouwer, Piet W.; Eisert, Jens; von Oppen, Felix

2016-11-01

We numerically investigate the distribution of Drude weights D of many-body states in disordered one-dimensional interacting electron systems across the transition to a many-body localized phase. Drude weights are proportional to the spectral curvatures induced by magnetic fluxes in mesoscopic rings. They offer a method to relate the transition to the many-body localized phase to transport properties. In the delocalized regime, we find that the Drude weight distribution at a fixed disorder configuration agrees well with the random-matrix-theory prediction P (D ) ∝(γ2+D2) -3 /2 , although the distribution width γ strongly fluctuates between disorder realizations. A crossover is observed towards a distribution with different large-D asymptotics deep in the many-body localized phase, which however differs from the commonly expected Cauchy distribution. We show that the average distribution width <γ >, rescaled by L Δ ,Δ being the average level spacing in the middle of the spectrum and L the systems size, is an efficient probe of the many-body localization transition, as it increases (vanishes) exponentially in the delocalized (localized) phase.

Multi-level modeling of total ionizing dose in a-silicon dioxide: First principles to circuits

NASA Astrophysics Data System (ADS)

Nicklaw, Christopher J.

Oxygen vacancies have long been known to be the dominant intrinsic defect in amorphous SiO2. They exist, in concentrations dependent on processing conditions, as neutral defects in thermal oxides without usually causing any significant deleterious effects, with some spatial and energy distribution. During irradiation they can capture holes and become positively charged E '-centers, contributing to device degradation. Over the years, a considerable database has been amassed on the dynamics of E' -centers in bulk SiO2 films, and near the interface under different irradiation and annealing conditions. Theoretical calculations so far have revealed the basic properties of prototype oxygen vacancies, primarily as they behave in either a crystalline quartz environment, or in small clusters that serve as a substitute for a real amorphous structure. To date at least three categories of E'-centers, existing at or above room temperature, have been observed in SiO2. The unifying feature is an unpaired electron on a threefold coordinated silicon atom, having the form O3 ≡ Si·. Feigl et al. identified the E'1 -center in crystalline quartz as a trapped hole on an oxygen vacancy, which causes an asymmetrical relaxation, resulting in a paramagnetic center. The unpaired electron in the E'1 -center is localized on the three-fold coordinated Si atoms, while the hole is localized on the other Si atom. Results from an ab initio statistical simulation examination of the behaviors of oxygen vacancies, within amorphous structures, identify a new form of the E'-center, the E'g5 and help in the understanding of the underlying physical mechanisms involved in switched-bias annealing, and electron paramagnetic resonance (EPR) studies. The results also suggest a common border trap, induced by trapped holes in SiO2, is a hole trapped at an oxygen vacancy defect, which can be compensated by an electron, as originally proposed by Lelis and co-workers at Harry Diamond Laboratories. This dissertation provides new insights into the basic mechanisms of a-SiO2 defects, and provides a link between basic mechanisms and Electronic Design Automation (EDA) tools, providing an enhanced design flow for radiation-resistant electronics.

National Apprenticeship and Training Standards for Carpentry. Revised.

ERIC Educational Resources Information Center

Employment and Training Administration (DOL), Washington, DC. Bureau of Apprenticeship and Training.

Designed to guide local organizations of contractors and journeymen in establishing and improving local apprenticeship systems, this booklet contains the latest revision of the National Joint Carpentry Apprenticeship and Training Committee standards pertaining to the basic requirements for effective apprenticeship. In a section on adapting…

Dispersion relations for a general anisotropic distribution function represented as a sum over Legendre polynomials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaisultanov, Rashid; Eichler, David

2011-03-15

The dielectric tensor is obtained for a general anisotropic distribution function that is represented as a sum over Legendre polynomials. The result is valid over all of k-space. We obtain growth rates for the Weibel instability for some basic examples of distribution functions.

Merchandise Display, a Distributive Education Manual and Answer Book.

ERIC Educational Resources Information Center

Hatchett, Melvin S.

This revised manual in basic merchandise display for trainees in distributive education, together with a separate answer key, contains 23 self-study assignments, each with training objectives, questions to answer, and student projects. Developed by a distributive education coordinator, these assignments cover a wide range of topics, from the…

Space Station power distribution and control

NASA Technical Reports Server (NTRS)

Willis, A. H.

1986-01-01

A general description of the Space Station is given with the basic requirements of the power distribution and controls system presented. The dual bus and branch circuit concepts are discussed and a computer control method presented.

GENASIS Basics: Object-oriented utilitarian functionality for large-scale physics simulations (Version 2)

NASA Astrophysics Data System (ADS)

Cardall, Christian Y.; Budiardja, Reuben D.

2017-05-01

GenASiS Basics provides Fortran 2003 classes furnishing extensible object-oriented utilitarian functionality for large-scale physics simulations on distributed memory supercomputers. This functionality includes physical units and constants; display to the screen or standard output device; message passing; I/O to disk; and runtime parameter management and usage statistics. This revision -Version 2 of Basics - makes mostly minor additions to functionality and includes some simplifying name changes.

Application of the Recreation Opportunity Spectrum for Outdoor Recreation Planning on Army Installations.

DTIC Science & Technology

1982-03-01

to preference types, and uses capacity estimation; therefore, it is basically a good system for recreation and resource inventory and classification...quan- tity, and distribution of recreational resources. Its basic unit of inventory is landform, or the homogeneity of physical features used to...by Clark and Stankey, "the basic assumption underlying the ROS is that quality recreational experiences are best assured by providing a diverse set of

The Time-Course of Ultrarapid Categorization: The Influence of Scene Congruency and Top-Down Processing.

PubMed

Vanmarcke, Steven; Calders, Filip; Wagemans, Johan

2016-01-01

Although categorization can take place at different levels of abstraction, classic studies on semantic labeling identified the basic level, for example, dog, as entry point for categorization. Ultrarapid categorization tasks have contradicted these findings, indicating that participants are faster at detecting superordinate-level information, for example, animal, in a complex visual image. We argue that both seemingly contradictive findings can be reconciled within the framework of parallel distributed processing and its successor Leabra (Local, Error-driven and Associative, Biologically Realistic Algorithm). The current study aimed at verifying this prediction in an ultrarapid categorization task with a dynamically changing presentation time (PT) for each briefly presented object, followed by a perceptual mask. Furthermore, we manipulated two defining task variables: level of categorization (basic vs. superordinate categorization) and object presentation mode (object-in-isolation vs. object-in-context). In contradiction with previous ultrarapid categorization research, focusing on reaction time, we used accuracy as our main dependent variable. Results indicated a consistent superordinate processing advantage, coinciding with an overall improvement in performance with longer PT and a significantly more accurate detection of objects in isolation, compared with objects in context, at lower stimulus PT. This contextual disadvantage disappeared when PT increased, indicating that figure-ground separation with recurrent processing is vital for meaningful contextual processing to occur.

The Time-Course of Ultrarapid Categorization: The Influence of Scene Congruency and Top-Down Processing

PubMed Central

Calders, Filip; Wagemans, Johan

2016-01-01

Although categorization can take place at different levels of abstraction, classic studies on semantic labeling identified the basic level, for example, dog, as entry point for categorization. Ultrarapid categorization tasks have contradicted these findings, indicating that participants are faster at detecting superordinate-level information, for example, animal, in a complex visual image. We argue that both seemingly contradictive findings can be reconciled within the framework of parallel distributed processing and its successor Leabra (Local, Error-driven and Associative, Biologically Realistic Algorithm). The current study aimed at verifying this prediction in an ultrarapid categorization task with a dynamically changing presentation time (PT) for each briefly presented object, followed by a perceptual mask. Furthermore, we manipulated two defining task variables: level of categorization (basic vs. superordinate categorization) and object presentation mode (object-in-isolation vs. object-in-context). In contradiction with previous ultrarapid categorization research, focusing on reaction time, we used accuracy as our main dependent variable. Results indicated a consistent superordinate processing advantage, coinciding with an overall improvement in performance with longer PT and a significantly more accurate detection of objects in isolation, compared with objects in context, at lower stimulus PT. This contextual disadvantage disappeared when PT increased, indicating that figure-ground separation with recurrent processing is vital for meaningful contextual processing to occur. PMID:27803794

Incorporation of Consumer Education [Lessons] in Adult Basic Education Programs in North Dakota. Final Report.

ERIC Educational Resources Information Center

Shurr, Harriet

Two North Dakota home economists developed consumer education curricula based on adult performance level (APL) objectives and the perceived needs of their vocational students. They worked with local directors of adult basic and secondary education (ABSE) to incorporate the curricula into regular ABSE classes. Project objectives were to (1)…

A Transonic Wind-Tunnel Investigation of the Performance and of the Static Stability and Control Characteristics of a Model of a Fighter-Type Airplane which Embodies Partial Body Indentation

NASA Technical Reports Server (NTRS)

Bielat, Ralph P.

1959-01-01

An investigation was conducted to obtain the aerodynamic characteristics of a model of a fighter-type airplane embodying partial body indentation. The wing had an aspect ratio of 4, taper ratio of 0.5, 35 deg sweepback of the 0.25-chord line, and a modified NACA 65A006 airfoil section at the root and a modified NACA 65A004 airfoil section at the tip. The fuselage has been indented in the region of the wing in order to obtain a favorable area distribution. The results reported herein consist of the performance and of the static longitudinal and lateral stability and control characteristics of the complete model. The Mach number range extended from 0.60 to 1.13, and the corresponding Reynolds number based on the wing mean aerodynamic chord varied from 1.77 x 10(exp 6) to 2.15 x 10(exp 6). The drag rise for both the cambered leading edge and symmetrical wing sections occurred at a Mach number of 0.95. Certain local modifications to the body which further improved the distribution of cross-sectional area gave additional reductions in drag at a Mach number of 1.00. The basic configuration indicated a mild pitch-up tendency at lift coefficients near 0.70 for the Mach number range from 0.80 to 0.90; however, the pitch-up instability may not be too objectionable on the basis of dynamic-stability considerations. The basic configuration indicated positive directional stability and positive effective dihedral through the angle-of-attack range and Mach number range with the exception of a region of negative effective dihedral at low lifts at Mach numbers of 1.00 and slightly above.

Research on Grid Size Suitability of Gridded Population Distribution in Urban Area: A Case Study in Urban Area of Xuanzhou District, China.

PubMed

Dong, Nan; Yang, Xiaohuan; Cai, Hongyan; Xu, Fengjiao

2017-01-01

The research on the grid size suitability is important to provide improvement in accuracies of gridded population distribution. It contributes to reveal the actual spatial distribution of population. However, currently little research has been done in this area. Many well-modeled gridded population dataset are basically built at a single grid scale. If the grid cell size is not appropriate, it will result in spatial information loss or data redundancy. Therefore, in order to capture the desired spatial variation of population within the area of interest, it is necessary to conduct research on grid size suitability. This study summarized three expressed levels to analyze grid size suitability, which include location expressed level, numeric information expressed level, and spatial relationship expressed level. This study elaborated the reasons for choosing the five indexes to explore expression suitability. These five indexes are consistency measure, shape index rate, standard deviation of population density, patches diversity index, and the average local variance. The suitable grid size was determined by constructing grid size-indicator value curves and suitable grid size scheme. Results revealed that the three expressed levels on 10m grid scale are satisfying. And the population distribution raster data with 10m grid size provide excellent accuracy without loss. The 10m grid size is recommended as the appropriate scale for generating a high-quality gridded population distribution in our study area. Based on this preliminary study, it indicates the five indexes are coordinated with each other and reasonable and effective to assess grid size suitability. We also suggest choosing these five indexes in three perspectives of expressed level to carry out the research on grid size suitability of gridded population distribution.

Research on Grid Size Suitability of Gridded Population Distribution in Urban Area: A Case Study in Urban Area of Xuanzhou District, China

PubMed Central

Dong, Nan; Yang, Xiaohuan; Cai, Hongyan; Xu, Fengjiao

2017-01-01

The research on the grid size suitability is important to provide improvement in accuracies of gridded population distribution. It contributes to reveal the actual spatial distribution of population. However, currently little research has been done in this area. Many well-modeled gridded population dataset are basically built at a single grid scale. If the grid cell size is not appropriate, it will result in spatial information loss or data redundancy. Therefore, in order to capture the desired spatial variation of population within the area of interest, it is necessary to conduct research on grid size suitability. This study summarized three expressed levels to analyze grid size suitability, which include location expressed level, numeric information expressed level, and spatial relationship expressed level. This study elaborated the reasons for choosing the five indexes to explore expression suitability. These five indexes are consistency measure, shape index rate, standard deviation of population density, patches diversity index, and the average local variance. The suitable grid size was determined by constructing grid size-indicator value curves and suitable grid size scheme. Results revealed that the three expressed levels on 10m grid scale are satisfying. And the population distribution raster data with 10m grid size provide excellent accuracy without loss. The 10m grid size is recommended as the appropriate scale for generating a high-quality gridded population distribution in our study area. Based on this preliminary study, it indicates the five indexes are coordinated with each other and reasonable and effective to assess grid size suitability. We also suggest choosing these five indexes in three perspectives of expressed level to carry out the research on grid size suitability of gridded population distribution. PMID:28122050

New experimental research stand SVICKA neutron field analysis using neutron activation detector technique

NASA Astrophysics Data System (ADS)

Varmuza, Jan; Katovsky, Karel; Zeman, Miroslav; Stastny, Ondrej; Haysak, Ivan; Holomb, Robert

2018-04-01

Knowledge of neutron energy spectra is very important because neutrons with various energies have a different material impact or a biological tissue impact. This paper presents basic results of the neutron flux distribution inside the new experimental research stand SVICKA which is located at Brno University of Technology in Brno, Czech Republic. The experiment also focused on the investigation of the sandwich biological shielding quality that protects staff against radiation effects. The set of indium activation detectors was used to the investigation of neutron flux distribution. The results of the measurement provide basic information about the neutron flux distribution inside all irradiation channels and no damage or cracks are present in the experimental research stand biological shielding.

Linear velocity fields in non-Gaussian models for large-scale structure

NASA Technical Reports Server (NTRS)

Scherrer, Robert J.

1992-01-01

Linear velocity fields in two types of physically motivated non-Gaussian models are examined for large-scale structure: seed models, in which the density field is a convolution of a density profile with a distribution of points, and local non-Gaussian fields, derived from a local nonlinear transformation on a Gaussian field. The distribution of a single component of the velocity is derived for seed models with randomly distributed seeds, and these results are applied to the seeded hot dark matter model and the global texture model with cold dark matter. An expression for the distribution of a single component of the velocity in arbitrary local non-Gaussian models is given, and these results are applied to such fields with chi-squared and lognormal distributions. It is shown that all seed models with randomly distributed seeds and all local non-Guassian models have single-component velocity distributions with positive kurtosis.

A bio-inspired swarm robot coordination algorithm for multiple target searching

NASA Astrophysics Data System (ADS)

Meng, Yan; Gan, Jing; Desai, Sachi

2008-04-01

The coordination of a multi-robot system searching for multi targets is challenging under dynamic environment since the multi-robot system demands group coherence (agents need to have the incentive to work together faithfully) and group competence (agents need to know how to work together well). In our previous proposed bio-inspired coordination method, Local Interaction through Virtual Stigmergy (LIVS), one problem is the considerable randomness of the robot movement during coordination, which may lead to more power consumption and longer searching time. To address these issues, an adaptive LIVS (ALIVS) method is proposed in this paper, which not only considers the travel cost and target weight, but also predicting the target/robot ratio and potential robot redundancy with respect to the detected targets. Furthermore, a dynamic weight adjustment is also applied to improve the searching performance. This new method a truly distributed method where each robot makes its own decision based on its local sensing information and the information from its neighbors. Basically, each robot only communicates with its neighbors through a virtual stigmergy mechanism and makes its local movement decision based on a Particle Swarm Optimization (PSO) algorithm. The proposed ALIVS algorithm has been implemented on the embodied robot simulator, Player/Stage, in a searching target. The simulation results demonstrate the efficiency and robustness in a power-efficient manner with the real-world constraints.

Restoration of oyster reefs in an estuarine lake: population dynamics and shell accretion

USGS Publications Warehouse

Casas, Sandra M.; La Peyre, Jerome F.; La Peyre, Megan K.

2015-01-01

Restoration activities inherently depend on understanding the spatial and temporal variation in basic demographic rates of the species of interest. For species that modify and maintain their own habitat such as the eastern oyster Crassostrea virginica, understanding demographic rates and their impacts on population and habitat success are crucial to ensuring restoration success. We measured oyster recruitment, density, size distribution, biomass, mortality and Perkinsus marinus infection intensity quarterly for 3 yr on shallow intertidal reefs created with shell cultch in March 2009. All reefs were located within Sister Lake, LA. Reefs were placed in pairs at 3 different locations within the lake; pairs were placed in low and medium energy sites within each location. Restored reefs placed within close proximity (<8 km) experienced very different development trajectories; there was high inter-site and inter-annual variation in recruitment and mortality of oysters, with only slight variation in growth curves. Despite this high variation in population dynamics, all reefs supported dense oyster populations (728 ± 102 ind. m-2) and high live oyster biomass (>14.6 kg m-2) at the end of 3 yr. Shell accretion, on average, exceeded estimated rates required to keep pace with local subsidence and shell loss. Variation in recruitment, growth and survival drives local site-specific population success, which highlights the need to understand local water quality, hydrodynamics, and metapopulation dynamics when planning restoration.

Concentration rather than dose defines the local brain toxicity of agents that are effectively distributed by convection-enhanced delivery.

PubMed

Zhang, Rong; Saito, Ryuta; Mano, Yui; Kanamori, Masayuki; Sonoda, Yukihiko; Kumabe, Toshihiro; Tominaga, Teiji

2014-01-30

Convection-enhanced delivery (CED) has been developed as a potentially effective drug-delivery strategy into the central nervous system. In contrast to systemic intravenous administration, local delivery achieves high concentration and prolonged retention in the local tissue, with increased chance of local toxicity, especially with toxic agents such as chemotherapeutic agents. Therefore, the factors that affect local toxicity should be extensively studied. With the assumption that concentration-oriented evaluation of toxicity is important for local CED, we evaluated the appearance of local toxicity among different agents after delivery with CED and studied if it is dose dependent or concentration dependent. Local toxicity profile of chemotherapeutic agents delivered via CED indicates BCNU was dose-dependent, whereas that of ACNU was concentration-dependent. On the other hand, local toxicity for doxorubicin, which is not distributed effectively by CED, was dose-dependent. Local toxicity for PLD, which is extensively distributed by CED, was concentration-dependent. Traditional evaluation of drug induced toxicity was dose-oriented. This is true for systemic intravascular delivery. However, with local CED, toxicity of several drugs exacerbated in concentration-dependent manner. From our study, local toxicity of drugs that are likely to distribute effectively tended to be concentration-dependent. Concentration rather than dose may be more important for the toxicity of agents that are effectively distributed by CED. Concentration-oriented evaluation of toxicity is more important for CED. Copyright © 2013 Elsevier B.V. All rights reserved.

Lewis Information Network (LINK): Background and overview

NASA Technical Reports Server (NTRS)

Schulte, Roger R.

1987-01-01

The NASA Lewis Research Center supports many research facilities with many isolated buildings, including wind tunnels, test cells, and research laboratories. These facilities are all located on a 350 acre campus adjacent to the Cleveland Hopkins Airport. The function of NASA-Lewis is to do basic and applied research in all areas of aeronautics, fluid mechanics, materials and structures, space propulsion, and energy systems. These functions require a great variety of remote high speed, high volume data communications for computing and interactive graphic capabilities. In addition, new requirements for local distribution of intercenter video teleconferencing and data communications via satellite have developed. To address these and future communications requirements for the next 15 yrs, a project team was organized to design and implement a new high speed communication system that would handle both data and video information in a common lab-wide Local Area Network. The project team selected cable television broadband coaxial cable technology as the communications medium and first installation of in-ground cable began in the summer of 1980. The Lewis Information Network (LINK) became operational in August 1982 and has become the backbone of all data communications and video.

Urban shrinkage in Germany and the USA: a comparison of transformation patterns and local strategies.

PubMed

Wiechmann, Thorsten; Pallagst, Karina M

2012-01-01

Many American and European cities have to deal with demographic and economic trajectories leading to urban shrinkage. According to official data, 13% of urban regions in the US and 54% of those in the EU have lost population in recent years. However, the extent and spatial distribution of declining populations differ significantly between Europe and the US. In Germany, the situation is driven by falling birth rates and the effects of German reunification. In the US, shrinkage is basically related to long-term industrial transformation. But the challenges of shrinking cities seldom appeared on the agendas of politicians and urban planners until recently. This article provides a critical overview of the development paths and local strategies of four shrinking cities: Schwedt and Dresden in eastern Germany; Youngstown and Pittsburgh in the US. A typology of urban growth and shrinkage, from economic and demographic perspectives, enables four types of city to be differentiated and the differences between the US and eastern Germany to be discussed. The article suggests that a new transatlantic debate on policy and planning strategies for restructuring shrinking cities is needed to overcome the dominant growth orientation that in most cases intensifies the negative consequences of shrinkage.

Decentralization and human resource management in the health sector: a case study (1996-1998) from Nampula province, Mozambique.

PubMed

Saide, M A; Stewart, D E

2001-01-01

Despite political, cultural and geographical diversity, health care reforms implemented in many developing countries share a number of common features regarding management and structural issues. Decentralization of decision-making from the central authority to local and provincial levels is generally regarded in the literature to be an important way of achieving a more equitable distribution of health care and better management practices, aligned with local priorities and needs. However, in the absence of clear guidelines, continuous monitoring and an adequate supply of financial and human resources, decentralization processes are more likely to have a low impact on the process of health care reform and can, to a certain extent, provoke inequalities between regions in the same country. This qualitative study in Nampula province, Mozambique, was conducted to assess the impact of decentralization, through an analysis of the viewpoints of provincial health managers regarding their perceptions of the process, particularly with regard to the management of basic and elementary nurses. Secondary data from Nampula provincial reports and documents from the Mozambican Health Ministry were also reviewed and comparisons made with the experiences of other developing countries.

A framework for the assessment of the spatial and temporal patterns of threatened coastal delphinids

NASA Astrophysics Data System (ADS)

Wang, Jingzhen; Yang, Yingting; Yang, Feng; Li, Yuelin; Li, Lianjie; Lin, Derun; He, Tangtian; Liang, Bo; Zhang, Tao; Lin, Yao; Li, Ping; Liu, Wenhua

2016-01-01

The massively accelerated biodiversity loss rate in the Anthropocene calls for an efficient and effective way to identify the spatial and temporal dynamics of endangered species. To this end, we developed a useful identification framework based on a case study of locally endangered Sousa chinensis by combining both LEK (local ecological knowledge) evaluation and regional boat-based survey methods. Our study investigated the basic ecological information of Sousa chinensis in the estuaries of eastern Guangdong that had previously been neglected, which could guide the future study and conservation. Based on the statistical testing of reported spatial and temporal dolphins sighting data from fishermen and the ecological monitoring analyses, including sighting rate, site fidelity and residence time estimations, some of the current Sousa chinensis units are likely to be geographically isolated and critically endangered, which calls for much greater conservation efforts. Given the accelerated population extinction rate and increasing budgetary constraints, our survey pattern can be applied in a timely and economically acceptable manner to the spatial and temporal assessment of other threatened coastal delphinids, particularly when population distributions are on a large scale and traditional sampling methods are difficult to implement.

STEADY-STATE MODEL OF SOLAR WIND ELECTRONS REVISITED

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoon, Peter H.; Kim, Sunjung; Choe, G. S., E-mail: yoonp@umd.edu

2015-10-20

In a recent paper, Kim et al. put forth a steady-state model for the solar wind electrons. The model assumed local equilibrium between the halo electrons, characterized by an intermediate energy range, and the whistler-range fluctuations. The basic wave–particle interaction is assumed to be the cyclotron resonance. Similarly, it was assumed that a dynamical steady state is established between the highly energetic superhalo electrons and high-frequency Langmuir fluctuations. Comparisons with the measured solar wind electron velocity distribution function (VDF) during quiet times were also made, and reasonable agreements were obtained. In such a model, however, only the steady-state solution for themore » Fokker–Planck type of electron particle kinetic equation was considered. The present paper complements the previous analysis by considering both the steady-state particle and wave kinetic equations. It is shown that the model halo and superhalo electron VDFs, as well as the assumed wave intensity spectra for the whistler and Langmuir fluctuations, approximately satisfy the quasi-linear wave kinetic equations in an approximate sense, thus further validating the local equilibrium model constructed in the paper by Kim et al.« less

Nuclear Architecture of Mouse Spermatocytes: Chromosome Topology, Heterochromatin, and Nucleolus.

PubMed

Berrios, Soledad

2017-01-01

The nuclear organization of spermatocytes in meiotic prophase I is primarily determined by the synaptic organization of the bivalents that are bound by their telomeres to the nuclear envelope and described as arc-shaped trajectories through the 3D nuclear space. However, over this basic meiotic organization, a spermatocyte nuclear architecture arises that is based on higher-ordered patterns of spatial associations among chromosomal domains from different bivalents that are conditioned by the individual characteristics of chromosomes and the opportunity for interactions between their domains. Consequently, the nuclear architecture is species-specific and prone to modification by chromosomal rearrangements. This model is valid for the localization of any chromosomal domain in the meiotic prophase nucleus. However, constitutive heterochromatin plays a leading role in shaping nuclear territories. Thus, the nuclear localization of nucleoli depends on the position of NORs in nucleolar bivalents, but the association among nucleolar chromosomes mainly depends on the presence of constitutive heterochromatin that does not affect the expression of the ribosomal genes. Constitutive heterochromatin and nucleoli form complex nuclear territories whose distribution in the nuclear space is nonrandom, supporting the hypothesis regarding the existence of a species-specific nuclear architecture in first meiotic prophase spermatocytes. © 2017 S. Karger AG, Basel.

A framework for the assessment of the spatial and temporal patterns of threatened coastal delphinids.

PubMed

Wang, Jingzhen; Yang, Yingting; Yang, Feng; Li, Yuelin; Li, Lianjie; Lin, Derun; He, Tangtian; Liang, Bo; Zhang, Tao; Lin, Yao; Li, Ping; Liu, Wenhua

2016-01-25

The massively accelerated biodiversity loss rate in the Anthropocene calls for an efficient and effective way to identify the spatial and temporal dynamics of endangered species. To this end, we developed a useful identification framework based on a case study of locally endangered Sousa chinensis by combining both LEK (local ecological knowledge) evaluation and regional boat-based survey methods. Our study investigated the basic ecological information of Sousa chinensis in the estuaries of eastern Guangdong that had previously been neglected, which could guide the future study and conservation. Based on the statistical testing of reported spatial and temporal dolphins sighting data from fishermen and the ecological monitoring analyses, including sighting rate, site fidelity and residence time estimations, some of the current Sousa chinensis units are likely to be geographically isolated and critically endangered, which calls for much greater conservation efforts. Given the accelerated population extinction rate and increasing budgetary constraints, our survey pattern can be applied in a timely and economically acceptable manner to the spatial and temporal assessment of other threatened coastal delphinids, particularly when population distributions are on a large scale and traditional sampling methods are difficult to implement.

Medicine information leaflets for non-steroidal anti-inflammatory drugs in Thailand.

PubMed

Phueanpinit, Pacharaporn; Pongwecharak, Juraporn; Krska, Janet; Jarernsiripornkul, Narumol

2016-02-01

The importance of promoting the use of patient-oriented medicines leaflets is recognized in many countries. Leaflets should include basic information plus specific warnings, and be provided with all medicines, but there is little attempt at enforcement of these requirements in Thailand. To determine content and availability of Thai information leaflets for nonsteroidal anti-inflammatory drugs (NSAIDs). Leaflets for all NSAIDs available for purchase from 34 pharmacies in a large city were evaluated against a checklist and number of leaflets assessed against number of medicine packs available in each pharmacy. Of the 76 leaflets for ten different NSAIDs, 67 (88 %) were for locally manufactured products. Only 22 % of 76 leaflets were sufficient in number for distribution with medicines, while only 4 % had patient-oriented leaflets. No leaflet covered all topics in the checklist. Less than half included safety information, such as contraindications (46 %), precautions (47 %), and adverse drug reactions (34 %). Locally-produced leaflets provided less information than those for originator products and no leaflet included all the warnings required by Thai regulations. This study illustrates the variable availability and quality of NSAID information leaflets. The lack of accessible essential information about medicines in Thailand requires urgent attention to enable patients to minimise adverse reactions.

Resolution of Infinite-Loop in Hyperincursive and Nonlocal Cellular Automata: Introduction to Slime Mold Computing

NASA Astrophysics Data System (ADS)

Aono, Masashi; Gunji, Yukio-Pegio

2004-08-01

How can non-algorithmic/non-deterministic computational syntax be computed? "The hyperincursive system" introduced by Dubois is an anticipatory system embracing the contradiction/uncertainty. Although it may provide a novel viewpoint for the understanding of complex systems, conventional digital computers cannot run faithfully as the hyperincursive computational syntax specifies, in a strict sense. Then is it an imaginary story? In this paper we try to argue that it is not. We show that a model of complex systems "Elementary Conflictable Cellular Automata (ECCA)" proposed by Aono and Gunji is embracing the hyperincursivity and the nonlocality. ECCA is based on locality-only type settings basically as well as other CA models, and/but at the same time, each cell is required to refer to globality-dominant regularity. Due to this contradictory locality-globality loop, the time evolution equation specifies that the system reaches the deadlock/infinite-loop. However, we show that there is a possibility of the resolution of these problems if the computing system has parallel and/but non-distributed property like an amoeboid organism. This paper is an introduction to "the slime mold computing" that is an attempt to cultivate an unconventional notion of computation.

Galaxy Groups in the 2Mass Redshift Survey

NASA Astrophysics Data System (ADS)

Lu, Yi; Yang, Xiaohu; Shi, Feng; Mo, H. J.; Tweed, Dylan; Wang, Huiyuan; Zhang, Youcai; Li, Shijie; Lim, S. H.

2016-11-01

A galaxy group catalog is constructed from the 2MASS Redshift Survey (2MRS) with the use of a halo-based group finder. The halo mass associated with a group is estimated using a “GAP” method based on the luminosity of the central galaxy and its gap with other member galaxies. Tests using mock samples show that this method is reliable, particularly for poor systems containing only a few members. On average, 80% of all the groups have completeness \\gt 0.8, and about 65% of the groups have zero contamination. Halo masses are estimated with a typical uncertainty of ∼ 0.35 {dex}. The application of the group finder to the 2MRS gives 29,904 groups from a total of 43,246 galaxies at z≤slant 0.08, with 5286 groups having two or more members. Some basic properties of this group catalog is presented, and comparisons are made with other group catalogs in overlap regions. With a depth to z∼ 0.08 and uniformly covering about 91% of the whole sky, this group catalog provides a useful database to study galaxies in the local cosmic web, and to reconstruct the mass distribution in the local universe.

Water-resources investigations of the U.S. Geological Survey in Kansas; fiscal years 1981 and 1982

USGS Publications Warehouse

Kenny, J.F.; Combs, L.J.

1983-01-01

One of the primary missions of the U.S. Geological Survey in Kansas is to investigate the occurrence, quantity, quality, distribution, and movement of surface and groundwater throughout the State. Primary activities include the systematic collection, analysis, and interpretation of hydrologic data, evaluation of water demands, and water-resources research. Hydrologic investigations are conducted through four basic types of projects: (1) data-collection programs, (2) local or areal investigations, (3) statewide or regional investigations, and (4) research projects. These projects are funded through cooperative agreements with State and local agencies, transfer of funds from other Federal agencies, and direct Federal funds. Forty-two water-related projects were funded during fiscal years 1981 and 1982 in Kansas. This report describes for each of these water-resources investigations the problem that initiated the study, the objectives of the project, and the approach designed to achieve this objective. Information on data-collection stations in Kansas is presented in maps and tables. A list of reports approved for publication by the U.S. Geological Survey, its cooperators, or technical and scientific organizations during fiscal years 1981 and 1982 is also provided. (USGS)

Water-resources activities of the U.S. Geological Survey in Kansas; fiscal years 1983 and 1984

USGS Publications Warehouse

Combs, L.J.

1985-01-01

The principal mission of the U.S. Geological Survey, Water Resources Division, in Kansas is to investigate the occurrence, quantity, quality, distribution, and movement of surface and ground waters throughout the State. Primary activities include the systematic collection, analysis, and interpretation of hydrologic data, evaluation of water demands, and water-resources research. Hydrologic investigations are conducted through four basic types of projects: (1) data-collection programs, (2) local or areal investigations, (3) statewide or regional investigations, and (4) research projects. These projects are funded through cooperative agreements with State and local agencies, transfer of funds from other Federal agencies, and direct Federal funds. Fifty water-related projects were ongoing during fiscal years 1983 and 1984 in Kansas. This report describes for each of these water-resources activities the problem that initiated the study, the objectives of the project, and the approach designed to achieve these objectives. Information on data-collection stations in Kansas is presented in maps and tables. A list of the 40 reports approved for publication by the U.S. Geological Survey, its cooperators, or technical and scientific organizations during 1983 and 1984 is provided. (USGS)

A Legal Guide for the Software Developer.

ERIC Educational Resources Information Center

Minnesota Small Business Assistance Office, St. Paul.

This booklet has been prepared to familiarize the inventor, creator, or developer of a new computer software product or software invention with the basic legal issues involved in developing, protecting, and distributing the software in the United States. Basic types of software protection and related legal matters are discussed in detail,…

Representativeness of individual external doses estimated for one quarter of residents in the Fukushima Prefecture after the nuclear disaster: the Fukushima Health Management Survey.

PubMed

Ishikawa, Tetsuo; Takahashi, Hideto; Yasumura, Seiji; Ohtsuru, Akira; Sakai, Akira; Ohira, Tetsuya; Sakata, Ritsu; Ozasa, Kotaro; Akahane, Keiichi; Yonai, Shunsuke; Kurihara, Osamu; Kamiya, Kenji; Abe, Masafumi

2017-09-25

After the Fukushima Dai-ichi Nuclear Power Plant accident, the Fukushima Health Management Survey (FHMS) was launched. The Basic Survey, a component of FHMS, is a questionnaire used to survey residents across the Fukushima Prefecture about their behaviour in the first 4 months after the accident. The questionnaire findings are used to determine individual external doses by linking behaviour data to a computer programme with daily gamma ray dose rate maps, drawn after the accident. Through 30 June 2015, the response rate was only 27.2% (558 550 population), indicating that the findings might not be generalisable because of poor representativeness of the population. The objective of this study was to clarify if the data from the FHMS Basic Survey were representative of the entire population, by conducting a new survey to compare the external doses between non-respondents and respondents in the previous survey. A total of 5350 subjects were randomly selected from 7 local regions of Fukushima Prefecture. An interview survey was conducted with the non-respondents to the FHMS Basic Survey. A total of 990 responses were obtained from the previous non-responders by interview survey. For the regions Kempoku, Kenchu, Kennan, Aizu, Minami-Aizu, Soso, and Iwaki, differences in mean effective dose (95% confidence interval) in mSv between the non-responders and previous responders were 0.12 (0.01-0.23), -0.09 (-0.21-0.03), -0.06 (-0.18-0.07), 0.05 (-0.04-0.14), 0.01 (-0.01-0.02), 0.09 (0.01-0.17), 0.09 (0.00-0.17), respectively. The differences fall neither within the interval (-∞, -0.25) nor within the interval (0.25, ∞). These findings imply that mean effective doses between the previous and new respondents were not different, with a significantly indifferent region of 0.25 mSv according to equivalence tests. The present study indicates that the dose distribution obtained from about one-quarter of Fukushima residents represents the dose distribution for the entire Fukushima Prefecture.

EERE's State & Local Energy Data Tool

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shambarger, Erick; DeCesaro, Jennifer

2014-06-23

EERE's State and Local Energy Data (SLED) Tool provides basic energy market information that can help state and local governments plan and implement clean energy projects, including electricity generation; fuel sources and costs; applicable policies, regulations, and financial incentives; and renewable energy resource potential. Watch this video to learn more about the tool and hear testimonials from real users about the benefits of using this tool.

EERE's State & Local Energy Data Tool

ScienceCinema

Shambarger, Erick; DeCesaro, Jennifer

2018-05-30

EERE's State and Local Energy Data (SLED) Tool provides basic energy market information that can help state and local governments plan and implement clean energy projects, including electricity generation; fuel sources and costs; applicable policies, regulations, and financial incentives; and renewable energy resource potential. Watch this video to learn more about the tool and hear testimonials from real users about the benefits of using this tool.

On the vulnerability of basic quantum key distribution protocols and three protocols stable to attack with 'blinding' of avalanche photodetectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Molotkov, S. N., E-mail: sergei.molotkov@gmail.com

2012-05-15

The fundamental quantum mechanics prohibitions on the measurability of quantum states allow secure key distribution between spatially remote users to be performed. Experimental and commercial implementations of quantum cryptography systems, however, use components that exist at the current technology level, in particular, one-photon avalanche photodetectors. These detectors are subject to the blinding effect. It was shown that all the known basic quantum key distribution protocols and systems based on them are vulnerable to attacks with blinding of photodetectors. In such attacks, an eavesdropper knows all the key transferred, does not produce errors at the reception side, and remains undetected. Threemore » protocols of quantum key distribution stable toward such attacks are suggested. The security of keys and detection of eavesdropping attempts are guaranteed by the internal structure of protocols themselves rather than additional technical improvements.« less

Extending HPF for advanced data parallel applications

NASA Technical Reports Server (NTRS)

Chapman, Barbara; Mehrotra, Piyush; Zima, Hans

1994-01-01

The stated goal of High Performance Fortran (HPF) was to 'address the problems of writing data parallel programs where the distribution of data affects performance'. After examining the current version of the language we are led to the conclusion that HPF has not fully achieved this goal. While the basic distribution functions offered by the language - regular block, cyclic, and block cyclic distributions - can support regular numerical algorithms, advanced applications such as particle-in-cell codes or unstructured mesh solvers cannot be expressed adequately. We believe that this is a major weakness of HPF, significantly reducing its chances of becoming accepted in the numeric community. The paper discusses the data distribution and alignment issues in detail, points out some flaws in the basic language, and outlines possible future paths of development. Furthermore, we briefly deal with the issue of task parallelism and its integration with the data parallel paradigm of HPF.

Approaching the Linguistic Complexity

NASA Astrophysics Data System (ADS)

Drożdż, Stanisław; Kwapień, Jarosław; Orczyk, Adam

We analyze the rank-frequency distributions of words in selected English and Polish texts. We compare scaling properties of these distributions in both languages. We also study a few small corpora of Polish literary texts and find that for a corpus consisting of texts written by different authors the basic scaling regime is broken more strongly than in the case of comparable corpus consisting of texts written by the same author. Similarly, for a corpus consisting of texts translated into Polish from other languages the scaling regime is broken more strongly than for a comparable corpus of native Polish texts. Moreover, based on the British National Corpus, we consider the rank-frequency distributions of the grammatically basic forms of words (lemmas) tagged with their proper part of speech. We find that these distributions do not scale if each part of speech is analyzed separately. The only part of speech that independently develops a trace of scaling is verbs.

Edge detection and localization with edge pattern analysis and inflection characterization

NASA Astrophysics Data System (ADS)

Jiang, Bo

2012-05-01

In general edges are considered to be abrupt changes or discontinuities in two dimensional image signal intensity distributions. The accuracy of front-end edge detection methods in image processing impacts the eventual success of higher level pattern analysis downstream. To generalize edge detectors designed from a simple ideal step function model to real distortions in natural images, research on one dimensional edge pattern analysis to improve the accuracy of edge detection and localization proposes an edge detection algorithm, which is composed by three basic edge patterns, such as ramp, impulse, and step. After mathematical analysis, general rules for edge representation based upon the classification of edge types into three categories-ramp, impulse, and step (RIS) are developed to reduce detection and localization errors, especially reducing "double edge" effect that is one important drawback to the derivative method. But, when applying one dimensional edge pattern in two dimensional image processing, a new issue is naturally raised that the edge detector should correct marking inflections or junctions of edges. Research on human visual perception of objects and information theory pointed out that a pattern lexicon of "inflection micro-patterns" has larger information than a straight line. Also, research on scene perception gave an idea that contours have larger information are more important factor to determine the success of scene categorization. Therefore, inflections or junctions are extremely useful features, whose accurate description and reconstruction are significant in solving correspondence problems in computer vision. Therefore, aside from adoption of edge pattern analysis, inflection or junction characterization is also utilized to extend traditional derivative edge detection algorithm. Experiments were conducted to test my propositions about edge detection and localization accuracy improvements. The results support the idea that these edge detection method improvements are effective in enhancing the accuracy of edge detection and localization.

The Distributed Nature of Pattern Generalization

ERIC Educational Resources Information Center

Rivera, Ferdinand

2015-01-01

Drawing on a review of recent work conducted in the area of pattern generalization (PG), this paper makes a case for a distributed view of PG, which basically situates processing ability in terms of convergences among several different factors that influence PG. Consequently, the distributed nature leads to different types of PG that depend on the…

Exact protein distributions for stochastic models of gene expression using partitioning of Poisson processes.

PubMed

Pendar, Hodjat; Platini, Thierry; Kulkarni, Rahul V

2013-04-01

Stochasticity in gene expression gives rise to fluctuations in protein levels across a population of genetically identical cells. Such fluctuations can lead to phenotypic variation in clonal populations; hence, there is considerable interest in quantifying noise in gene expression using stochastic models. However, obtaining exact analytical results for protein distributions has been an intractable task for all but the simplest models. Here, we invoke the partitioning property of Poisson processes to develop a mapping that significantly simplifies the analysis of stochastic models of gene expression. The mapping leads to exact protein distributions using results for mRNA distributions in models with promoter-based regulation. Using this approach, we derive exact analytical results for steady-state and time-dependent distributions for the basic two-stage model of gene expression. Furthermore, we show how the mapping leads to exact protein distributions for extensions of the basic model that include the effects of posttranscriptional and posttranslational regulation. The approach developed in this work is widely applicable and can contribute to a quantitative understanding of stochasticity in gene expression and its regulation.

Exact protein distributions for stochastic models of gene expression using partitioning of Poisson processes

NASA Astrophysics Data System (ADS)

Pendar, Hodjat; Platini, Thierry; Kulkarni, Rahul V.

2013-04-01

Stochasticity in gene expression gives rise to fluctuations in protein levels across a population of genetically identical cells. Such fluctuations can lead to phenotypic variation in clonal populations; hence, there is considerable interest in quantifying noise in gene expression using stochastic models. However, obtaining exact analytical results for protein distributions has been an intractable task for all but the simplest models. Here, we invoke the partitioning property of Poisson processes to develop a mapping that significantly simplifies the analysis of stochastic models of gene expression. The mapping leads to exact protein distributions using results for mRNA distributions in models with promoter-based regulation. Using this approach, we derive exact analytical results for steady-state and time-dependent distributions for the basic two-stage model of gene expression. Furthermore, we show how the mapping leads to exact protein distributions for extensions of the basic model that include the effects of posttranscriptional and posttranslational regulation. The approach developed in this work is widely applicable and can contribute to a quantitative understanding of stochasticity in gene expression and its regulation.

42 CFR 422.252 - Terminology.

Code of Federal Regulations, 2010 CFR

2010-10-01

... § 422.252 Terminology. Annual MA capitation rate means a county payment rate for an MA local area... to refer to the annual MA capitation rate. MA local area means a payment area consisting of county or equivalent area specified by CMS. MA monthly basic beneficiary premium means the premium amount an MA plan...

Eastern Oklahoma Johnson-O'Malley Indian Education Handbook.

ERIC Educational Resources Information Center

Martinson, Shirley

Intended as a guide and reference for persons involved in local administration of the Johnson-O'Malley (JOM) Indian Education program, the handbook contains basic information about the program and the roles and responsibilities of school administrators, JOM personnel, and local and state Indian Education Committees (IECs). Beginning with a history…

Rural Workplace Literacy: Community College Partnerships.

ERIC Educational Resources Information Center

Barnett, Lynn, Ed.

In 1990, the American Association of Community and Junior Colleges developed a national workplace literacy demonstration project to raise awareness of the link between local economic development and basic workplace skill performance, and to stimulate a local leadership initiative around a community-wide effort to raise worker performance levels.…

Category representations in the brain are both discretely localized and widely distributed.

PubMed

Shehzad, Zarrar; McCarthy, Gregory

2018-06-01

Whether category information is discretely localized or represented widely in the brain remains a contentious issue. Initial functional MRI studies supported the localizationist perspective that category information is represented in discrete brain regions. More recent fMRI studies using machine learning pattern classification techniques provide evidence for widespread distributed representations. However, these latter studies have not typically accounted for shared information. Here, we find strong support for distributed representations when brain regions are considered separately. However, localized representations are revealed by using analytical methods that separate unique from shared information among brain regions. The distributed nature of shared information and the localized nature of unique information suggest that brain connectivity may encourage spreading of information but category-specific computations are carried out in distinct domain-specific regions. NEW & NOTEWORTHY Whether visual category information is localized in unique domain-specific brain regions or distributed in many domain-general brain regions is hotly contested. We resolve this debate by using multivariate analyses to parse functional MRI signals from different brain regions into unique and shared variance. Our findings support elements of both models and show information is initially localized and then shared among other regions leading to distributed representations being observed.

Design and experimental observation of valley-Hall edge states in diatomic-graphene-like elastic waveguides

NASA Astrophysics Data System (ADS)

Zhu, Hongfei; Liu, Ting-Wei; Semperlotti, Fabio

2018-05-01

We report on the design and experimental validation of a two-dimensional phononic elastic waveguide exhibiting topological valley-Hall edge states. The lattice structure of the waveguide is inspired by diatomic graphene, and it is imprinted in an initially flat plate by means of geometric indentations. The indentations are distributed according to a hexagonal lattice structure which guarantees the existence of Dirac dispersion at the boundary of the Brillouin zone. Starting from this basic material, domain walls capable of supporting edge states can be obtained by contrasting waveguides having broken space-inversion symmetry (SIS) achieved by using local resonant elements. Our theoretical study shows that such material maps into the acoustic analog of the quantum valley-Hall effect, while numerical and experimental results confirm the existence of protected edge states traveling along the walls of topologically distinct domains.

Descriptive epidemiology of cardiovascular risk factors and diabetes in sub-Saharan Africa.

PubMed

Mensah, George A

2013-01-01

Reliable data on risk factor levels, exposure history, and population distribution can help inform policies and programs for disease prevention and control. With rare exception however, ideal local data on major risk factors and causes of death and disease burden have been scarce in sub-Saharan Africa (SSA). Basic community surveys in some countries and recent systematic analysis of disease burden attributable to 67 risk factors and risk factor clusters in 21 regions of the world provide an opportunity to examine and relate diabetes and cardiovascular risk factors to mortality and burden in SSA. Rising body mass index, especially in women in Southern Africa; and rising systolic blood pressure in East Africa for both sexes, and in West Africa for women are the major cardiometabolic risk factors. Harmful use of alcohol, especially in Southern SSA, tobacco use, and physical inactivity are also important. Improving vital registration and risk factor surveillance remain major challenges. © 2013.

Fractality à la carte: a general particle aggregation model.

PubMed

Nicolás-Carlock, J R; Carrillo-Estrada, J L; Dossetti, V

2016-01-19

In nature, fractal structures emerge in a wide variety of systems as a local optimization of entropic and energetic distributions. The fractality of these systems determines many of their physical, chemical and/or biological properties. Thus, to comprehend the mechanisms that originate and control the fractality is highly relevant in many areas of science and technology. In studying clusters grown by aggregation phenomena, simple models have contributed to unveil some of the basic elements that give origin to fractality, however, the specific contribution from each of these elements to fractality has remained hidden in the complex dynamics. Here, we propose a simple and versatile model of particle aggregation that is, on the one hand, able to reveal the specific entropic and energetic contributions to the clusters' fractality and morphology, and, on the other, capable to generate an ample assortment of rich natural-looking aggregates with any prescribed fractal dimension.

Coarse-grained forms for equations describing the microscopic motion of particles in a fluid.

PubMed

Das, Shankar P; Yoshimori, Akira

2013-10-01

Exact equations of motion for the microscopically defined collective density ρ(x,t) and the momentum density ĝ(x,t) of a fluid have been obtained in the past starting from the corresponding Langevin equations representing the dynamics of the fluid particles. In the present work we average these exact equations of microscopic dynamics over the local equilibrium distribution to obtain stochastic partial differential equations for the coarse-grained densities with smooth spatial and temporal dependence. In particular, we consider Dean's exact balance equation for the microscopic density of a system of interacting Brownian particles to obtain the basic equation of the dynamic density functional theory with noise. Our analysis demonstrates that on thermal averaging the dependence of the exact equations on the bare interaction potential is converted to dependence on the corresponding thermodynamic direct correlation functions in the coarse-grained equations.

Application of SQUIDs for registration of biomagnetic signals

NASA Astrophysics Data System (ADS)

Voitovych, I. D.; Primin, M. A.; Sosnytskyy, V. N.

2012-04-01

Supersensitive magnetometric systems based on low-temperature SQUIDs have been designed to conduct research in cardiology (magnetocardiography) and to examine distribution of magnetic nanoparticles in biologic objects. Such SQUID magnetometric systems are distinguished by their noise immunity enabling research in nonscreened rooms. High repeatability of research outcomes has been confirmed. The use of magnetocardiographic systems has permitted a new screening information technology to be developed to diagnose heart diseases at early stages. Magnetic imaging of heart's action currents is an ideal way to test local electrical heterogeneity of myocardium. It is shown that magnetocardiography has a significant potential for both basic science of analysis of heart's biosignals and clinical cardiologic practice. A SQUID magnetometric system measuring magnetic signals radiated by the organs of laboratory animals is described. Information technology for automatic recording and transforming magnetometric data has been developed; the measurement of signals over rats' livers while injecting intravenously the nanoparticles of iron oxides and lead solutions are presented.

Cardinal rules: Visual orientation perception reflects knowledge of environmental statistics

PubMed Central

Girshick, Ahna R.; Landy, Michael S.; Simoncelli, Eero P.

2011-01-01

Humans are remarkably good at performing visual tasks, but experimental measurements reveal substantial biases in the perception of basic visual attributes. An appealing hypothesis is that these biases arise through a process of statistical inference, in which information from noisy measurements is fused with a probabilistic model of the environment. But such inference is optimal only if the observer’s internal model matches the environment. Here, we provide evidence that this is the case. We measured performance in an orientation-estimation task, demonstrating the well-known fact that orientation judgements are more accurate at cardinal (horizontal and vertical) orientations, along with a new observation that judgements made under conditions of uncertainty are strongly biased toward cardinal orientations. We estimate observers’ internal models for orientation and find that they match the local orientation distribution measured in photographs. We also show how a neural population could embed probabilistic information responsible for such biases. PMID:21642976

Basic investigation into the electrical performance of solid electrolyte membranes

NASA Technical Reports Server (NTRS)

Richter, R.

1982-01-01

The electrical performance of solid electrolyte membranes was investigated analytically and the results were compared with experimental data. It is concluded that in devices that are used for pumping oxygen the major power losses have to be attributed to the thin film electrodes. Relations were developed by which the effectiveness of tubular solid electrolyte membranes can be determined and the optimum length evaluated. The observed failure of solid electrolyte tube membranes in very localized areas is explained by the highly non-uniform current distribution in the membranes. The analysis points to a possible contact resistance between the electrodes and the solid electrolyte material. This possible contact resistance remains to be investigated experimentally. It is concluded that film electrodes are not appropriate for devices which operate with current flow, i.e., pumps though they can be employed without reservation in devices that measure oxygen pressures if a limited increase in the response time can be tolerated.

Coal Combustion Science quarterly progress report, April--June 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hardesty, D.R.; Hurt, R.H.; Baxter, L.L.

1992-09-01

The objective of this work is to support the Office of Fossil Energy in executing research on coal combustion science. This project consists of basic research on coal combustion that supports both the Pittsburgh Energy Technology Center (PETC) Direct Utilization Advanced Research and Technology Development Program, and the International Energy Agency (IEA) Coal Combustion Science Project. Specific tasks include: The characterization of the physical and chemical processes that constitute the early devolatilization phase of coal combustion: Characterization of the combustion behavior of selected coals under conditions relevant to industria pulverized coal-fired furnaces; and to establish a quantitative understanding of themore » mechanisms and rates of transformation, fragmentation, and deposition of mineral matter in coal combustion environments as a function of coal type, particle size and temperature, the initial forms and distributions of mineral species in the unreacted coal, and the local gas temperature and composition.« less

A Comparison of Three Programming Models for Adaptive Applications

NASA Technical Reports Server (NTRS)

Shan, Hong-Zhang; Singh, Jaswinder Pal; Oliker, Leonid; Biswa, Rupak; Kwak, Dochan (Technical Monitor)

2000-01-01

We study the performance and programming effort for two major classes of adaptive applications under three leading parallel programming models. We find that all three models can achieve scalable performance on the state-of-the-art multiprocessor machines. The basic parallel algorithms needed for different programming models to deliver their best performance are similar, but the implementations differ greatly, far beyond the fact of using explicit messages versus implicit loads/stores. Compared with MPI and SHMEM, CC-SAS (cache-coherent shared address space) provides substantial ease of programming at the conceptual and program orchestration level, which often leads to the performance gain. However it may also suffer from the poor spatial locality of physically distributed shared data on large number of processors. Our CC-SAS implementation of the PARMETIS partitioner itself runs faster than in the other two programming models, and generates more balanced result for our application.

Basics of particle therapy I: physics

PubMed Central

Park, Seo Hyun

2011-01-01

With the advance of modern radiation therapy technique, radiation dose conformation and dose distribution have improved dramatically. However, the progress does not completely fulfill the goal of cancer treatment such as improved local control or survival. The discordances with the clinical results are from the biophysical nature of photon, which is the main source of radiation therapy in current field, with the lower linear energy transfer to the target. As part of a natural progression, there recently has been a resurgence of interest in particle therapy, specifically using heavy charged particles, because these kinds of radiations serve theoretical advantages in both biological and physical aspects. The Korean government is to set up a heavy charged particle facility in Korea Institute of Radiological & Medical Sciences. This review introduces some of the elementary physics of the various particles for the sake of Korean radiation oncologists' interest. PMID:22984664

Microwave ablation devices for interventional oncology.

PubMed

Ward, Robert C; Healey, Terrance T; Dupuy, Damian E

2013-03-01

Microwave ablation is one of the several options in the ablation armamentarium for the treatment of malignancy, offering several potential benefits when compared with other ablation, radiation, surgical and medical treatment modalities. The basic microwave system consists of the generator, power distribution system and antennas. Often under image (computed tomography or ultrasound) guidance, a needle-like antenna is inserted percutaneously into the tumor, where local microwave electromagnetic radiation is emitted from the probe's active tip, producing frictional tissue heating, capable of causing cell death by coagulation necrosis. Half of the microwave ablation systems use a 915 MHz generator and the other half use a 2450 MHz generator. To date, there are no completed clinical trials comparing microwave devices head-to-head. Prospective comparisons of microwave technology with other treatment alternatives, as well as head-to-head comparison with each microwave device, is needed if this promising field will garner more widespread support and use in the oncology community.

Single-ion microwave near-field quantum sensor

NASA Astrophysics Data System (ADS)

Wahnschaffe, M.; Hahn, H.; Zarantonello, G.; Dubielzig, T.; Grondkowski, S.; Bautista-Salvador, A.; Kohnen, M.; Ospelkaus, C.

2017-01-01

We develop an intuitive model of 2D microwave near-fields in the unusual regime of centimeter waves localized to tens of microns. Close to an intensity minimum, a simple effective description emerges with five parameters that characterize the strength and spatial orientation of the zero and first order terms of the near-field, as well as the field polarization. Such a field configuration is realized in a microfabricated planar structure with an integrated microwave conductor operating near 1 GHz. We use a single 9 Be+ ion as a high-resolution quantum sensor to measure the field distribution through energy shifts in its hyperfine structure. We find agreement with simulations at the sub-micron and few-degree level. Our findings give a clear and general picture of the basic properties of oscillatory 2D near-fields with applications in quantum information processing, neutral atom trapping and manipulation, chip-scale atomic clocks, and integrated microwave circuits.

Modelling students' knowledge organisation: Genealogical conceptual networks

NASA Astrophysics Data System (ADS)

Koponen, Ismo T.; Nousiainen, Maija

2018-04-01

Learning scientific knowledge is largely based on understanding what are its key concepts and how they are related. The relational structure of concepts also affects how concepts are introduced in teaching scientific knowledge. We model here how students organise their knowledge when they represent their understanding of how physics concepts are related. The model is based on assumptions that students use simple basic linking-motifs in introducing new concepts and mostly relate them to concepts that were introduced a few steps earlier, i.e. following a genealogical ordering. The resulting genealogical networks have relatively high local clustering coefficients of nodes but otherwise resemble networks obtained with an identical degree distribution of nodes but with random linking between them (i.e. the configuration-model). However, a few key nodes having a special structural role emerge and these nodes have a higher than average communicability betweenness centralities. These features agree with the empirically found properties of students' concept networks.

Smart Building: Decision Making Architecture for Thermal Energy Management.

PubMed

Uribe, Oscar Hernández; Martin, Juan Pablo San; Garcia-Alegre, María C; Santos, Matilde; Guinea, Domingo

2015-10-30

Smart applications of the Internet of Things are improving the performance of buildings, reducing energy demand. Local and smart networks, soft computing methodologies, machine intelligence algorithms and pervasive sensors are some of the basics of energy optimization strategies developed for the benefit of environmental sustainability and user comfort. This work presents a distributed sensor-processor-communication decision-making architecture to improve the acquisition, storage and transfer of thermal energy in buildings. The developed system is implemented in a near Zero-Energy Building (nZEB) prototype equipped with a built-in thermal solar collector, where optical properties are analysed; a low enthalpy geothermal accumulation system, segmented in different temperature zones; and an envelope that includes a dynamic thermal barrier. An intelligent control of this dynamic thermal barrier is applied to reduce the thermal energy demand (heating and cooling) caused by daily and seasonal weather variations. Simulations and experimental results are presented to highlight the nZEB thermal energy reduction.

PEBBLE: a two-dimensional steady-state pebble bed reactor thermal hydraulics code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vondy, D.R.

1981-09-01

This report documents the local implementation of the PEBBLE code to treat the two-dimensional steady-state pebble bed reactor thermal hydraulics problem. This code is implemented as a module of a computation system used for reactor core history calculations. Given power density data, the geometric description in (RZ), and basic heat removal conditions and thermal properties, the coolant properties, flow conditions, and temperature distributions in the pebble fuel elements are predicted. The calculation is oriented to the continuous fueling, steady state condition with consideration of the effect of the high energy neutron flux exposure and temperature history on the thermal conductivity.more » The coolant flow conditions are calculated for the same geometry as used in the neutronics calculation, power density and fluence data being used directly, and temperature results are made available for subsequent use.« less

Quantifying randomness in real networks

NASA Astrophysics Data System (ADS)

Orsini, Chiara; Dankulov, Marija M.; Colomer-de-Simón, Pol; Jamakovic, Almerima; Mahadevan, Priya; Vahdat, Amin; Bassler, Kevin E.; Toroczkai, Zoltán; Boguñá, Marián; Caldarelli, Guido; Fortunato, Santo; Krioukov, Dmitri

2015-10-01

Represented as graphs, real networks are intricate combinations of order and disorder. Fixing some of the structural properties of network models to their values observed in real networks, many other properties appear as statistical consequences of these fixed observables, plus randomness in other respects. Here we employ the dk-series, a complete set of basic characteristics of the network structure, to study the statistical dependencies between different network properties. We consider six real networks--the Internet, US airport network, human protein interactions, technosocial web of trust, English word network, and an fMRI map of the human brain--and find that many important local and global structural properties of these networks are closely reproduced by dk-random graphs whose degree distributions, degree correlations and clustering are as in the corresponding real network. We discuss important conceptual, methodological, and practical implications of this evaluation of network randomness, and release software to generate dk-random graphs.

A low speed two-dimensional study of flow separation on the GA(W)-1 airfoil with 30-percent chord Fowler flap

NASA Technical Reports Server (NTRS)

Seetharam, H. C.; Wentz, W. H., Jr.

1977-01-01

Measurements of flow fields with low speed turbulent boundary layers were made for the GA(W)-1 airfoil with a 0.30 c Fowler flap deflected 40 deg at angles of attack of 2.7 deg, 7.7 deg, and 12.8 deg, at a Reynolds number of 2.2 million, and a Mach number of 0.13. Details of velocity and pressure fields associated with the airfoil flap combination are presented for cases of narrow, optimum and wide slot gaps. Extensive flow field turbulence surveys were also conducted employing hot-film anemometry. For the optimum gap setting, the boundaries of the regions of flow reversal within the wake were determined by this technique for two angles of attack. Local skin friction distributions for the basic airfoil and the airfoil with flap (optimum gap) were obtained using the razor blade technique.

[Multi-channel in vivo recording techniques: analysis of phase coupling between spikes and rhythmic oscillations of local field potentials].

PubMed

Wang, Ce-Qun; Chen, Qiang; Zhang, Lu; Xu, Jia-Min; Lin, Long-Nian

2014-12-25

The purpose of this article is to introduce the measurements of phase coupling between spikes and rhythmic oscillations of local field potentials (LFPs). Multi-channel in vivo recording techniques allow us to record ensemble neuronal activity and LFPs simultaneously from the same sites in the brain. Neuronal activity is generally characterized by temporal spike sequences, while LFPs contain oscillatory rhythms in different frequency ranges. Phase coupling analysis can reveal the temporal relationships between neuronal firing and LFP rhythms. As the first step, the instantaneous phase of LFP rhythms can be calculated using Hilbert transform, and then for each time-stamped spike occurred during an oscillatory epoch, we marked instantaneous phase of the LFP at that time stamp. Finally, the phase relationships between the neuronal firing and LFP rhythms were determined by examining the distribution of the firing phase. Phase-locked spikes are revealed by the non-random distribution of spike phase. Theta phase precession is a unique phase relationship between neuronal firing and LFPs, which is one of the basic features of hippocampal place cells. Place cells show rhythmic burst firing following theta oscillation within a place field. And phase precession refers to that rhythmic burst firing shifted in a systematic way during traversal of the field, moving progressively forward on each theta cycle. This relation between phase and position can be described by a linear model, and phase precession is commonly quantified with a circular-linear coefficient. Phase coupling analysis helps us to better understand the temporal information coding between neuronal firing and LFPs.

Deducing the multi-trader population driving a financial market

NASA Astrophysics Data System (ADS)

Gupta, Nachi; Hauser, Raphael; Johnson, Neil

2005-12-01

We have previously laid out a basic framework for predicting financial movements and pockets of predictability by tracking the distribution of a multi-trader population playing on an artificial financial market model. This work explores extensions to this basic framework. We allow for more intelligent agents with a richer strategy set, and we no longer constrain the distribution over these agents to a probability space. We then introduce a fusion scheme which accounts for multiple runs of randomly chosen sets of possible agent types. We also discuss a mechanism for bias removal on the estimates.

GIS-based niche modeling for mapping species' habitats

USGS Publications Warehouse

Rotenberry, J.T.; Preston, K.L.; Knick, S.

2006-01-01

Ecological a??niche modelinga?? using presence-only locality data and large-scale environmental variables provides a powerful tool for identifying and mapping suitable habitat for species over large spatial extents. We describe a niche modeling approach that identifies a minimum (rather than an optimum) set of basic habitat requirements for a species, based on the assumption that constant environmental relationships in a species' distribution (i.e., variables that maintain a consistent value where the species occurs) are most likely to be associated with limiting factors. Environmental variables that take on a wide range of values where a species occurs are less informative because they do not limit a species' distribution, at least over the range of variation sampled. This approach is operationalized by partitioning Mahalanobis D2 (standardized difference between values of a set of environmental variables for any point and mean values for those same variables calculated from all points at which a species was detected) into independent components. The smallest of these components represents the linear combination of variables with minimum variance; increasingly larger components represent larger variances and are increasingly less limiting. We illustrate this approach using the California Gnatcatcher (Polioptila californica Brewster) and provide SAS code to implement it.

BOCA BASIC BUILDING CODE. 4TH ED., 1965 AND 1967. BOCA BASIC BUILDING CODE ACCUMULATIVE SUPPLEMENT.

ERIC Educational Resources Information Center

Building Officials Conference of America, Inc., Chicago, IL.

NATIONALLY RECOGNIZED STANDARDS FOR THE EVALUATION OF MINIMUM SAFE PRACTICE OR FOR DETERMINING THE PERFORMANCE OF MATERIALS OR SYSTEMS OF CONSTRUCTION HAVE BEEN COMPILED AS AN AID TO DESIGNERS AND LOCAL OFFICIALS. THE CODE PRESENTS REGULATIONS IN TERMS OF MEASURED PERFORMANCE RATHER THAN IN RIGID SPECIFICATION OF MATERIALS OR METHODS. THE AREAS…

5 CFR 534.406 - Conversion to the SES pay system.

Code of Federal Regulations, 2010 CFR

2010-01-01

... to the SES pay system. (a) On the first day of the first applicable pay period beginning on or after... rate of basic pay that is equal to the employee's rate of basic pay, plus any applicable locality-based... first day of the first applicable pay period beginning on or after January 1, 2004. If an SES member's...

The Concept of "English Learning Power" and Its Implication for the Design of English Curricula for Primary and Middle Schools in China

ERIC Educational Resources Information Center

Dai, Zhongxin

2015-01-01

In the research on "New Characteristics of Future Basic Education in China," Dina Pei formulates a "three-powered" model to theorize about the characteristics of future basic education in China. The three powers refer to the "Policy-making Power" of the local educational administration, the "Leading Power"…

The Utility of the Dynamic Indicators of Basic Early Literacy Skills (DIBELS) in Predicting Reading Achievement

ERIC Educational Resources Information Center

Echols, Julie M. Young

2010-01-01

Reading proficiency is the goal of many local and national reading initiatives. A key component of these initiatives is accurate and reliable reading assessment. In this high-stakes testing arena, the Dynamic Indicators of Basic Early Literacy Skills (DIBELS) has emerged as a preferred measure for identification of students at risk for reading…

Numerical analysis of tailored sheets to improve the quality of components made by SPIF

NASA Astrophysics Data System (ADS)

Gagliardi, Francesco; Ambrogio, Giuseppina; Cozza, Anna; Pulice, Diego; Filice, Luigino

2018-05-01

In this paper, the authors pointed out a study on the profitable combination of forming techniques. More in detail, the attention has been put on the combination of the single point incremental forming (SPIF) and, generally, speaking, of an additional process that can lead to a material thickening on the initial blank considering the local thinning which the sheets undergo at. Focalizing the attention of the research on the excessive thinning of parts made by SPIF, a hybrid approach can be thought as a viable solution to reduce the not homogeneous thickness distribution of the sheet. In fact, the basic idea is to work on a blank previously modified by a deformation step performed, for instance, by forming, additive or subtractive processes. To evaluate the effectiveness of this hybrid solution, a FE numerical model has been defined to analyze the thickness variation on tailored sheets incrementally formed optimizing the material distribution according to the shape to be manufactured. Simulations based on the explicit formulation have been set up for the model implementation. The mechanical properties of the sheet material have been taken in literature and a frustum of cone as benchmark profile has been considered for the performed analysis. The outcomes of numerical model have been evaluated in terms of both maximum thinning and final thickness distribution. The feasibility of the proposed approach will be deeply detailed in the paper.

A system for distributed intrusion detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snapp, S.R.; Brentano, J.; Dias, G.V.

1991-01-01

The study of providing security in computer networks is a rapidly growing area of interest because the network is the medium over which most attacks or intrusions on computer systems are launched. One approach to solving this problem is the intrusion-detection concept, whose basic premise is that not only abandoning the existing and huge infrastructure of possibly-insecure computer and network systems is impossible, but also replacing them by totally-secure systems may not be feasible or cost effective. Previous work on intrusion-detection systems were performed on stand-alone hosts and on a broadcast local area network (LAN) environment. The focus of ourmore » present research is to extend our network intrusion-detection concept from the LAN environment to arbitarily wider areas with the network topology being arbitrary as well. The generalized distributed environment is heterogeneous, i.e., the network nodes can be hosts or servers from different vendors, or some of them could be LAN managers, like our previous work, a network security monitor (NSM), as well. The proposed architecture for this distributed intrusion-detection system consists of the following components: a host manager in each host; a LAN manager for monitoring each LAN in the system; and a central manager which is placed at a single secure location and which receives reports from various host and LAN managers to process these reports, correlate them, and detect intrusions. 11 refs., 2 figs.« less

Modular and hierarchical structure of social contact networks

NASA Astrophysics Data System (ADS)

Ge, Yuanzheng; Song, Zhichao; Qiu, Xiaogang; Song, Hongbin; Wang, Yong

2013-10-01

Social contact networks exhibit overlapping qualities of communities, hierarchical structure and spatial-correlated nature. We propose a mixing pattern of modular and growing hierarchical structures to reconstruct social contact networks by using an individual’s geospatial distribution information in the real world. The hierarchical structure of social contact networks is defined based on the spatial distance between individuals, and edges among individuals are added in turn from the modular layer to the highest layer. It is a gradual process to construct the hierarchical structure: from the basic modular model up to the global network. The proposed model not only shows hierarchically increasing degree distribution and large clustering coefficients in communities, but also exhibits spatial clustering features of individual distributions. As an evaluation of the method, we reconstruct a hierarchical contact network based on the investigation data of a university. Transmission experiments of influenza H1N1 are carried out on the generated social contact networks, and results show that the constructed network is efficient to reproduce the dynamic process of an outbreak and evaluate interventions. The reproduced spread process exhibits that the spatial clustering of infection is accordant with the clustering of network topology. Moreover, the effect of individual topological character on the spread of influenza is analyzed, and the experiment results indicate that the spread is limited by individual daily contact patterns and local clustering topology rather than individual degree.

Astrophysical uncertainties on the local dark matter distribution and direct detection experiments

NASA Astrophysics Data System (ADS)

Green, Anne M.

2017-08-01

The differential event rate in weakly interacting massive particle (WIMP) direct detection experiments depends on the local dark matter density and velocity distribution. Accurate modelling of the local dark matter distribution is therefore required to obtain reliable constraints on the WIMP particle physics properties. Data analyses typically use a simple standard halo model which might not be a good approximation to the real Milky Way (MW) halo. We review observational determinations of the local dark matter density, circular speed and escape speed and also studies of the local dark matter distribution in simulated MW-like galaxies. We discuss the effects of the uncertainties in these quantities on the energy spectrum and its time and direction dependence. Finally, we conclude with an overview of various methods for handling these astrophysical uncertainties.

Measurement and dynamics of the spatial distribution of an electron localized at a metal-dielectric interface

NASA Astrophysics Data System (ADS)

Bezel, Ilya; Gaffney, Kelly J.; Garrett-Roe, Sean; Liu, Simon H.; Miller, André D.; Szymanski, Paul; Harris, Charles B.

2004-01-01

The ability of time- and angle-resolved two-photon photoemission to estimate the size distribution of electron localization in the plane of a metal-adsorbate interface is discussed. It is shown that the width of angular distribution of the photoelectric current is inversely proportional to the electron localization size within the most common approximations in the description of image potential states. The localization of the n=1 image potential state for two monolayers of butyronitrile on Ag(111) is used as an example. For the delocalized n=1 state, the shape of the signal amplitude as a function of momentum parallel to the surface changes rapidly with time, indicating efficient intraband relaxation on a 100 fs time scale. For the localized state, little change was observed. The latter is related to the constant size distribution of electron localization, which is estimated to be a Gaussian with a 15±4 Å full width at half maximum in the plane of the interface. A simple model was used to study the effect of a weak localization potential on the overall width of the angular distribution of the photoemitted electrons, which exhibited little sensitivity to the details of the potential. This substantiates the validity of the localization size estimate.

Experimental investigation of localized stress-induced leakage current distribution in gate dielectrics using array test circuit

NASA Astrophysics Data System (ADS)

Park, Hyeonwoo; Teramoto, Akinobu; Kuroda, Rihito; Suwa, Tomoyuki; Sugawa, Shigetoshi

2018-04-01

Localized stress-induced leakage current (SILC) has become a major problem in the reliability of flash memories. To reduce it, clarifying the SILC mechanism is important, and statistical measurement and analysis have to be carried out. In this study, we applied an array test circuit that can measure the SILC distribution of more than 80,000 nMOSFETs with various gate areas at a high speed (within 80 s) and a high accuracy (on the 10-17 A current order). The results clarified that the distributions of localized SILC in different gate areas follow a universal distribution assuming the same SILC defect density distribution per unit area, and the current of localized SILC defects does not scale down with the gate area. Moreover, the distribution of SILC defect density and its dependence on the oxide field for measurement (E OX-Measure) were experimentally determined for fabricated devices.

Improving Distributed Diagnosis Through Structural Model Decomposition

NASA Technical Reports Server (NTRS)

Bregon, Anibal; Daigle, Matthew John; Roychoudhury, Indranil; Biswas, Gautam; Koutsoukos, Xenofon; Pulido, Belarmino

2011-01-01

Complex engineering systems require efficient fault diagnosis methodologies, but centralized approaches do not scale well, and this motivates the development of distributed solutions. This work presents an event-based approach for distributed diagnosis of abrupt parametric faults in continuous systems, by using the structural model decomposition capabilities provided by Possible Conflicts. We develop a distributed diagnosis algorithm that uses residuals computed by extending Possible Conflicts to build local event-based diagnosers based on global diagnosability analysis. The proposed approach is applied to a multitank system, and results demonstrate an improvement in the design of local diagnosers. Since local diagnosers use only a subset of the residuals, and use subsystem models to compute residuals (instead of the global system model), the local diagnosers are more efficient than previously developed distributed approaches.

Local anesthesia selection algorithm in patients with concomitant somatic diseases.

PubMed

Anisimova, E N; Sokhov, S T; Letunova, N Y; Orekhova, I V; Gromovik, M V; Erilin, E A; Ryazantsev, N A

2016-01-01

The paper presents basic principles of local anesthesia selection in patients with concomitant somatic diseases. These principles are history taking; analysis of drugs interaction with local anesthetic and sedation agents; determination of the functional status of the patient; patient anxiety correction; dental care with monitoring of hemodynamics parameters. It was found that adhering to this algorithm promotes prevention of urgent conditions in patients in outpatient dentistry.

Far-field DOA estimation and source localization for different scenarios in a distributed sensor network

NASA Astrophysics Data System (ADS)

Asgari, Shadnaz

Recent developments in the integrated circuits and wireless communications not only open up many possibilities but also introduce challenging issues for the collaborative processing of signals for source localization and beamforming in an energy-constrained distributed sensor network. In signal processing, various sensor array processing algorithms and concepts have been adopted, but must be further tailored to match the communication and computational constraints. Sometimes the constraints are such that none of the existing algorithms would be an efficient option for the defined problem and as the result; the necessity of developing a new algorithm becomes undeniable. In this dissertation, we present the theoretical and the practical issues of Direction-Of-Arrival (DOA) estimation and source localization using the Approximate-Maximum-Likelihood (AML) algorithm for different scenarios. We first investigate a robust algorithm design for coherent source DOA estimation in a limited reverberant environment. Then, we provide a least-square (LS) solution for source localization based on our newly proposed virtual array model. In another scenario, we consider the determination of the location of a disturbance source which emits both wideband acoustic and seismic signals. We devise an enhanced AML algorithm to process the data collected at the acoustic sensors. For processing the seismic signals, two distinct algorithms are investigated to determine the DOAs. Then, we consider a basic algorithm for fusion of the results yielded by the acoustic and seismic arrays. We also investigate the theoretical and practical issues of DOA estimation in a three-dimensional (3D) scenario. We show that the performance of the proposed 3D AML algorithm converges to the Cramer-Rao Bound. We use the concept of an isotropic array to reduce the complexity of the proposed algorithm by advocating a decoupled 3D version. We also explore a modified version of the decoupled 3D AML algorithm which can be used for DOA estimation with non-isotropic arrays. In this dissertation, for each scenario, efficient numerical implementations of the corresponding AML algorithm are derived and applied into a real-time sensor network testbed. Extensive simulations as well as experimental results are presented to verify the effectiveness of the proposed algorithms.

Information flow in an atmospheric model and data assimilation

NASA Astrophysics Data System (ADS)

Yoon, Young-noh

2011-12-01

Weather forecasting consists of two processes, model integration and analysis (data assimilation). During the model integration, the state estimate produced by the analysis evolves to the next cycle time according to the atmospheric model to become the background estimate. The analysis then produces a new state estimate by combining the background state estimate with new observations, and the cycle repeats. In an ensemble Kalman filter, the probability distribution of the state estimate is represented by an ensemble of sample states, and the covariance matrix is calculated using the ensemble of sample states. We perform numerical experiments on toy atmospheric models introduced by Lorenz in 2005 to study the information flow in an atmospheric model in conjunction with ensemble Kalman filtering for data assimilation. This dissertation consists of two parts. The first part of this dissertation is about the propagation of information and the use of localization in ensemble Kalman filtering. If we can perform data assimilation locally by considering the observations and the state variables only near each grid point, then we can reduce the number of ensemble members necessary to cover the probability distribution of the state estimate, reducing the computational cost for the data assimilation and the model integration. Several localized versions of the ensemble Kalman filter have been proposed. Although tests applying such schemes have proven them to be extremely promising, a full basic understanding of the rationale and limitations of localization is currently lacking. We address these issues and elucidate the role played by chaotic wave dynamics in the propagation of information and the resulting impact on forecasts. The second part of this dissertation is about ensemble regional data assimilation using joint states. Assuming that we have a global model and a regional model of higher accuracy defined in a subregion inside the global region, we propose a data assimilation scheme that produces the analyses for the global and the regional model simultaneously, considering forecast information from both models. We show that our new data assimilation scheme produces better results both in the subregion and the global region than the data assimilation scheme that produces the analyses for the global and the regional model separately.

Three-Dimensional Numerical Simulation on Passively Excited Flows by Distributed Local Hot Sources Settled at the D" Layer Below Hotspots and/or Large-Scale Cool Masses at Subduction Zones Within the Static Layered Mantle

NASA Astrophysics Data System (ADS)

Eguchi, T.; Matsubara, K.; Ishida, M.

2001-12-01

To unveil dynamic process associated with three-dimensional unsteady mantle convection, we carried out numerical simulation on passively exerted flows by simplified local hot sources just above the CMB and large-scale cool masses beneath smoothed subduction zones. During the study, we used our individual code developed with the finite difference method. The basic three equations are for the continuity, the motion with the Boussinesq (incompressible) approximation, and the (thermal) energy conservation. The viscosity of our model is sensitive to temperature. To get time integration with high precision, we used the Newton method. In detail, the size and thermal energy of the hot or cool sources are not uniform along the latitude, because we could not select uniform local volumes assigned for the sources within the finite difference grids throughout the mantle. Our results, thus, accompany some latitude dependence. First, we treated the case of the hotspots, neglecting the contribution of the subduction zones. The local hot sources below the currently active hotspots were settled as dynamic driving forces included in the initial condition. Before starting the calculation, we assumed that the mantle was statically layered with zero velocity component. The thermal anomalies inserted instantaneously in the initial condition do excite dynamically passive flows. The type of the initial hot sources was not 'plume' but 'thermal.' The simulation results represent that local upwelling flows which were directly excited over the initial heat sources reached the upper mantle by approximately 30 My during the calculation. Each of the direct upwellings above the hotspots has its own dynamic potential to exert concentric down- and up-welling flows, alternately, at large distances. Simultaneously, the direct upwellings interact mutually within the spherical mantle. As an interesting feature, we numerically observed secondary upwellings somewhere in a wide region covering east Eurasia to the Bering Sea where no hot sources were initially input. It seems that the detailed location of the secondary upwellings depends partly on the numerical parameters such as the radial profile of mantle viscosity especially at the D" layer, etc., because the secondary flows are provoked by dynamic interaction among the distributed direct upwellings just above the CMB. Our results suggest that if we assume not only non-zero time delays during the input of the local hot sources but also parameters related with the difference of their historical surface flux rates, the pattern of the passively excited flows will be different from that obtained with the simultaneously settled hot sources stated above. Second, we simultaneously incorporated simplified thermal anomaly models associated with both the distributed local hotspots and the global subduction zones, as dynamic origins in the initial condition for the static layered mantle. In this case, the simulation result represents that the pattern of secondary radial flows, being different from those in the earlier case, is sensitive to the relative strength between the positive dynamic buoyancy integrated over all of the local hot sources below the hotspots and the total negative buoyancy beneath the subduction zones.

Temporal complexity in emission from Anderson localized lasers

NASA Astrophysics Data System (ADS)

Kumar, Randhir; Balasubrahmaniyam, M.; Alee, K. Shadak; Mujumdar, Sushil

2017-12-01

Anderson localization lasers exploit resonant cavities formed due to structural disorder. The inherent randomness in the structure of these cavities realizes a probability distribution in all cavity parameters such as quality factors, mode volumes, mode structures, and so on, implying resultant statistical fluctuations in the temporal behavior. Here we provide direct experimental measurements of temporal width distributions of Anderson localization lasing pulses in intrinsically and extrinsically disordered coupled-microresonator arrays. We first illustrate signature exponential decays in the spatial intensity distributions of the lasing modes that quantify their localized character, and then measure the temporal width distributions of the pulsed emission over several configurations. We observe a dependence of temporal widths on the disorder strength, wherein the widths show a single-peaked, left-skewed distribution in extrinsic disorder and a dual-peaked distribution in intrinsic disorder. We propose a model based on coupled rate equations for an emitter and an Anderson cavity with a random mode structure, which gives excellent quantitative and qualitative agreement with the experimental observations. The experimental and theoretical analyses bring to the fore the temporal complexity in Anderson-localization-based lasing systems.

Rupture preparation process controlled by surface roughness on meter-scale laboratory fault

NASA Astrophysics Data System (ADS)

Yamashita, Futoshi; Fukuyama, Eiichi; Xu, Shiqing; Mizoguchi, Kazuo; Kawakata, Hironori; Takizawa, Shigeru

2018-05-01

We investigate the effect of fault surface roughness on rupture preparation characteristics using meter-scale metagabbro specimens. We repeatedly conducted the experiments with the same pair of rock specimens to make the fault surface rough. We obtained three experimental results under the same experimental conditions (6.7 MPa of normal stress and 0.01 mm/s of loading rate) but at different roughness conditions (smooth, moderately roughened, and heavily roughened). During each experiment, we observed many stick-slip events preceded by precursory slow slip. We investigated when and where slow slip initiated by using the strain gauge data processed by the Kalman filter algorithm. The observed rupture preparation processes on the smooth fault (i.e. the first experiment among the three) showed high repeatability of the spatiotemporal distributions of slow slip initiation. Local stress measurements revealed that slow slip initiated around the region where the ratio of shear to normal stress (τ/σ) was the highest as expected from finite element method (FEM) modeling. However, the exact location of slow slip initiation was where τ/σ became locally minimum, probably due to the frictional heterogeneity. In the experiment on the moderately roughened fault, some irregular events were observed, though the basic characteristics of other regular events were similar to those on the smooth fault. Local stress data revealed that the spatiotemporal characteristics of slow slip initiation and the resulting τ/σ drop for irregular events were different from those for regular ones even under similar stress conditions. On the heavily roughened fault, the location of slow slip initiation was not consistent with τ/σ anymore because of the highly heterogeneous static friction on the fault, which also decreased the repeatability of spatiotemporal distributions of slow slip initiation. These results suggest that fault surface roughness strongly controls the rupture preparation process, and generally increases its complexity with the degree of roughness.

HIV Epidemic Appraisals for Assisting in the Design of Effective Prevention Programmes: Shifting the Paradigm Back to Basics

PubMed Central

Mishra, Sharmistha; Sgaier, Sema K.; Thompson, Laura H.; Moses, Stephen; Ramesh, B. M.; Alary, Michel; Wilson, David; Blanchard, James F.

2012-01-01

Background To design HIV prevention programmes, it is critical to understand the temporal and geographic aspects of the local epidemic and to address the key behaviours that drive HIV transmission. Two methods have been developed to appraise HIV epidemics and guide prevention strategies. The numerical proxy method classifies epidemics based on current HIV prevalence thresholds. The Modes of Transmission (MOT) model estimates the distribution of incidence over one year among risk-groups. Both methods focus on the current state of an epidemic and provide short-term metrics which may not capture the epidemiologic drivers. Through a detailed analysis of country and sub-national data, we explore the limitations of the two traditional methods and propose an alternative approach. Methods and Findings We compared outputs of the traditional methods in five countries for which results were published, and applied the numeric and MOT model to India and six districts within India. We discovered three limitations of the current methods for epidemic appraisal: (1) their results failed to identify the key behaviours that drive the epidemic; (2) they were difficult to apply to local epidemics with heterogeneity across district-level administrative units; and (3) the MOT model was highly sensitive to input parameters, many of which required extraction from non-regional sources. We developed an alternative decision-tree framework for HIV epidemic appraisals, based on a qualitative understanding of epidemiologic drivers, and demonstrated its applicability in India. The alternative framework offered a logical algorithm to characterize epidemics; it required minimal but key data. Conclusions Traditional appraisals that utilize the distribution of prevalent and incident HIV infections in the short-term could misguide prevention priorities and potentially impede efforts to halt the trajectory of the HIV epidemic. An approach that characterizes local transmission dynamics provides a potentially more effective tool with which policy makers can design intervention programmes. PMID:22396756

Statistical thermodynamics of protein folding: Comparison of a mean-field theory with Monte Carlo simulations

NASA Astrophysics Data System (ADS)

Hao, Ming-Hong; Scheraga, Harold A.

1995-01-01

A comparative study of protein folding with an analytical theory and computer simulations, respectively, is reported. The theory is based on an improved mean-field formalism which, in addition to the usual mean-field approximations, takes into account the distributions of energies in the subsets of conformational states. Sequence-specific properties of proteins are parametrized in the theory by two sets of variables, one for the energetics of mean-field interactions and one for the distribution of energies. Simulations are carried out on model polypeptides with different sequences, with different chain lengths, and with different interaction potentials, ranging from strong biases towards certain local chain states (bond angles and torsional angles) to complete absence of local conformational preferences. Theoretical analysis of the simulation results for the model polypeptides reveals three different types of behavior in the folding transition from the statistical coiled state to the compact globular state; these include a cooperative two-state transition, a continuous folding, and a glasslike transition. It is found that, with the fitted theoretical parameters which are specific for each polypeptide under a different potential, the mean-field theory can describe the thermodynamic properties and folding behavior of the different polypeptides accurately. By comparing the theoretical descriptions with simulation results, we verify the basic assumptions of the theory and, thereby, obtain new insights about the folding transitions of proteins. It is found that the cooperativity of the first-order folding transition of the model polypeptides is determined mainly by long-range interactions, in particular the dipolar orientation; the local interactions (e.g., bond-angle and torsion-angle potentials) have only marginal effect on the cooperative characteristic of the folding, but have a large impact on the difference in energy between the folded lowest-energy structure and the unfolded conformations of a protein.

A sequence of basic residues in the porcine circovirus type 2 capsid protein is crucial for its co-expression and co-localization with the replication protein.

PubMed

Huang, Liping; Van Renne, Nicolaas; Liu, Changming; Nauwynck, Hans J

2015-12-01

Porcine circovirus type 2 (PCV2) encodes two major proteins: the replication protein (Rep) and the capsid protein (Cap). Cap displays a conserved stretch of basic residues situated on the inside of the capsid, whose role is so far unknown. We used a reverse-genetics approach to investigate its function and found that mutations in these amino acids hindered Cap mRNA translation and hampered Cap/Rep co-localization, yielding unfit viruses. Intriguingly, co-transfection with a WT PCV2 of a different genotype partially rescued mutant Cap expression, showing the importance of this basic pattern for efficient translation of Cap mRNA into protein. Our results show that Cap and Rep are expressed independently of each other, and that this amino acid sequence of Cap is vital for virus propagation. This study provides a method for studying unfit PCV2 virions and offers new insights into the intracellular modus vivendi of PCV2.

The impact of socioeconomic status on stage specific prostate cancer survival and mortality before and after introduction of PSA test in Finland.

PubMed

Seikkula, Heikki A; Kaipia, Antti J; Ryynänen, Heidi; Seppä, Karri; Pitkäniemi, Janne M; Malila, Nea K; Boström, Peter J

2018-03-01

Socioeconomic status (SES) has an impact on prostate cancer (PCa) outcomes. Men with high SES have higher incidence and lower mortality of PCa versus lower SES males. PCa cases diagnosed in Finland in 1985-2014 (N = 95,076) were identified from the Finnish Cancer Registry. Information on education level (EL) was obtained from Statistics Finland. EL was assessed with three-tiered scale: basic, upper secondary and higher education. PCa stage at diagnosis was defined as localized, metastatic or unknown. Years of diagnosis 1985-1994 were defined as pre-PSA period and thereafter as post-PSA period. We report PCa-specific survival (PCSS) and relative risks (RR) for PCa specific mortality (PCSM) among cancer cases in Finland, where healthcare is 100% publicly reimbursed and inequality in healthcare services low. Men with higher EL had markedly better 10-year PCSS: 68 versus 63% in 1985-1994 and 90 versus 85% in 1995-2004 compared to basic EL in localized PCa. The RR for PCSM among men with localized PCa and higher EL compared to basic EL was 0.76(95%confidence interval (CI) 0.66-0.88) in 1985-1994 and 0.61(95%CI 0.53-0.70) in 1995-2004. Variation in PCSS and PCSM between EL categories was evident in metastatic PCa, too. The difference in PCSM between EL categories was larger in the first 10-year post-PSA period than before that but decreased thereafter in localized PCa, suggesting PSA testing became earlier popular among men with high EL. In summary, higher SES/EL benefit PCa survival both in local and disseminated disease and the effect of EL was more pronounced in early post-PSA period. © 2017 UICC.

An Introduction to Distributions Using Weighted Dice

ERIC Educational Resources Information Center

Holland, Bart K.

2011-01-01

Distributions are the basis for an enormous amount of theoretical and applied work in statistics. While there are formal definitions of distributions and many formulas to characterize them, it is important that students at first get a clear introduction to this basic concept. For many of them, neither words nor formulas can match the power of a…

Distance Learning: A Way of Life-Long Learning

DTIC Science & Technology

2005-09-01

promise of future benefits. 15. SUBJECT TERMS training, educational technology , distributed learning , distance learning , collaboration, online instruction...knowledge." - Aristotle Introduction Modern learning technology assumes various names: distance learning , distributed training, computer-based...training, web-based learning , or advanced distributed learning . No matter the name, the basic concept is using computer technology for instruction with no

Effects of turbulence on mixed-phase deep convective clouds under different basic-state winds and aerosol concentrations

NASA Astrophysics Data System (ADS)

Lee, Hyunho; Baik, Jong-Jin; Han, Ji-Young

2014-12-01

The effects of turbulence-induced collision enhancement (TICE) on mixed-phase deep convective clouds are numerically investigated using a 2-D cloud model with bin microphysics for uniform and sheared basic-state wind profiles and different aerosol concentrations. Graupel particles account for the most of the cloud mass in all simulation cases. In the uniform basic-state wind cases, graupel particles with moderate sizes account for some of the total graupel mass in the cases with TICE, whereas graupel particles with large sizes account for almost all the total graupel mass in the cases without TICE. This is because the growth of ice crystals into small graupel particles is enhanced due to TICE. The changes in the size distributions of graupel particles due to TICE result in a decrease in the mass-averaged mean terminal velocity of graupel particles. Therefore, the downward flux of graupel mass, and thus the melting of graupel particles, is reduced due to TICE, leading to a decrease in the amount of surface precipitation. Moreover, under the low aerosol concentration, TICE increases the sublimation of ice particles, consequently playing a partial role in reducing the amount of surface precipitation. The effects of TICE are less pronounced in the sheared basic-state wind cases than in the uniform basic-state wind cases because the number of ice crystals is much smaller in the sheared basic-state wind cases than in the uniform basic-state wind cases. Thus, the size distributions of graupel particles in the cases with and without TICE show little difference.

Enabling nutrient security and sustainability through systems research.

PubMed

Kaput, Jim; Kussmann, Martin; Mendoza, Yery; Le Coutre, Ronit; Cooper, Karen; Roulin, Anne

2015-05-01

Human and companion animal health depends upon nutritional quality of foods. Seed varieties, seasonal and local growing conditions, transportation, food processing, and storage, and local food customs can influence the nutrient content of food. A new and intensive area of investigation is emerging that recognizes many factors in these agri-food systems that influence the maintenance of nutrient quality which is fundamental to ensure nutrient security for world populations. Modeling how these systems function requires data from different sectors including agricultural, environmental, social, and economic, but also must incorporate basic nutrition and other biomedical sciences. Improving the agri-food system through advances in pre- and post-harvest processing methods, biofortification, or fortifying processed foods will aid in targeting nutrition for populations and individuals. The challenge to maintain and improve nutrient quality is magnified by the need to produce food locally and globally in a sustainable and consumer-acceptable manner for current and future populations. An unmet requirement for assessing how to improve nutrient quality, however, is the basic knowledge of how to define health. That is, health cannot be maintained or improved by altering nutrient quality without an adequate definition of what health means for individuals and populations. Defining and measuring health therefore becomes a critical objective for basic nutritional and other biomedical sciences.

5 CFR 531.606 - Maximum limits on locality rates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... than or equal to the maximum payable scheduled annual rate of pay for GS-15; or (ii) The rate for level... Section 531.606 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY... of basic pay payable for level IV of the Executive Schedule. (b)(1) A locality rate for an employee...

Colorado Department of Education Abbreviated Information Management Annual Plan (CDE IMAP).

ERIC Educational Resources Information Center

Laughlin, Richard

The Colorado Department of Education (CDE), including Access Colorado Library and Information Network (ACLIN) and the Colorado School for the Deaf and the Blind, provides state- level guidance and resources for Colorado's local school districts, local and regional libraries, and special populations. Technology is the enabler that offers basic,…

Action Research Localization in China: Three Cases

ERIC Educational Resources Information Center

Bai, Yimin

2009-01-01

Since the introduction of the action research into China in the 1980s, especially since the start of the twenty-first century, Chinese education researchers have been trying to localize it in relation to the backdrop of the national curriculum reform in basic education. This article presents three cases in which educators aimed for a conscious…

The Utah State Public School Finance Simulator

ERIC Educational Resources Information Center

Steffensen, Robert G.

1973-01-01

Reports on a simulator that shows the effect of proposed changes to school finance laws by legislatures on school administration. The simulator produces a report that (1) defines the basic units used to determine the dollar amounts to be disbursed to each local school district, (2) shows local school district disbursement amounts by program, and…

Local Area Networks in Education: Overview, Applications, and Current Limitations.

ERIC Educational Resources Information Center

Piele, Philip K.

Local area networks (LAN) are privately owned communication systems that connect multivendor devices at high speed. As microcomputers become more common in schools, user interest in sharing information, software, and peripherals will increase. A basic understanding of the operation of all LAN's can be gained by knowing four elements: media,…

State and Local Tax Performance, 1981 (Basic Tabulations).

ERIC Educational Resources Information Center

Quindry, Kenneth E.; Schoening, Niles C.

Fiscal year 1981 state and local tax performance data are presented, which indicate comparative utilization of taxable resources. Estimates are provided of tax ability for 15 major taxes and total taxes, and tax ability to tax collections for the 50 states and their subdivisions is compared. Tables include the following: population, personal…

A Guide to Federal Regulation; Understanding the FCC Rules.

ERIC Educational Resources Information Center

Cable Television Information Center, Washington, DC.

While it is apparent that the Federal Communications Commission (FCC) has given a great deal of thought to the regulation of cable systems, the basic success or failure of cable as a communications service will depend on local development. Relatively little guidance has been provided to local franchising authorities for selecting among applicants,…

The Role of Self-Organized Criticality in the Substorm Phenomenon and its Relation to Localized Reconnection in the Magnetospheric Plasma Sheet

NASA Technical Reports Server (NTRS)

Klimas, Alex J.; Valdivia, J. A.; Vassiliadis, D.; Baker, D. N.; Hesse, M.; Takalo, J.

1999-01-01

Evidence is presented that suggests there is a significant self-organized criticality (SOC) component in the dynamics of substorms in the magnetosphere. Observations of BBFs, fast flows, localized dipolarizations, plasma turbulence, etc. are taken to show that multiple localized reconnection sites provide the basic avalanche phenomenon in the establishment of SOC in the plasma sheet. First results are presented from a continuing plasma physical study of this avalanche process. A one-dimensional resistive MHD model of a magnetic field reversal is discussed. Resistivity, in this model, is self-consistently generated in response to the excitation of an idealized current-driven instability. When forced by convection of magnetic flux into the field reversal region, the model yields rapid magnetic field annihilation through a dynamic behavior that is shown to exhibit many of the characteristics of SOC. Over a large range of forcing strengths, the annihilation rate is shown to self-adjust to balance the rate at which flux is convected into the reversal region. Several analogies to magnetotail dynamics are discussed: (1) It is shown that the presence of a localized criticality in the model produces a remarkable stability in the global configuration of the field reversal while simultaneously exciting extraordinarily dynamic internal evolution. (2) Under steady forcing, it is shown that a loading-unloading cycle may arise that, as a consequence of the global stability, is quasi-periodic and, therefore, predictable despite the presence of internal turbulence in the field distribution. Indeed, it is shown that the global loading-unloading cycle is a consequence of the internal turbulence. (3) It is shown that, under steady, strong forcing the loading-unloading cycle vanishes. Instead, a recovery from a single unloading persists indefinitely. The field reversal is globally very steady while internally it is very dynamic as field annihilation goes on at the rate necessary to match the strong forcing. From this result we speculate that steady magnetospheric convection events result when the plasma sheet has been driven close to criticality over an extended spatial domain. During these events, we would expect to find localized reconnection sites distributed over the spatial domain of near criticality and we would expect to find plasma sheet transport in that domain to be closely related to that of BBF and fast flow events.

Intracorporeal Heat Distribution from Fully Implantable Energy Sources for Mechanical Circulatory Support: A Computational Proof-of-Concept Study

PubMed Central

Biasetti, Jacopo; Pustavoitau, Aliaksei; Spazzini, Pier Giorgio

2017-01-01

Mechanical circulatory support devices, such as total artificial hearts and left ventricular assist devices, rely on external energy sources for their continuous operation. Clinically approved power supplies rely on percutaneous cables connecting an external energy source to the implanted device with the associated risk of infections. One alternative, investigated in the 70s and 80s, employs a fully implanted nuclear power source. The heat generated by the nuclear decay can be converted into electricity to power circulatory support devices. Due to the low conversion efficiencies, substantial levels of waste heat are generated and must be dissipated to avoid tissue damage, heat stroke, and death. The present work computationally evaluates the ability of the blood flow in the descending aorta to remove the locally generated waste heat for subsequent full-body distribution and dissipation, with the specific aim of investigating methods for containment of local peak temperatures within physiologically acceptable limits. To this aim, coupled fluid–solid heat transfer computational models of the blood flow in the human aorta and different heat exchanger architectures are developed. Particle tracking is used to evaluate temperature histories of cells passing through the heat exchanger region. The use of the blood flow in the descending aorta as a heat sink proves to be a viable approach for the removal of waste heat loads. With the basic heat exchanger design, blood thermal boundary layer temperatures exceed 50°C, possibly damaging blood cells and proteins. Improved designs of the heat exchanger, with the addition of fins and heat guides, allow for drastically lower blood temperatures, possibly leading to a more biocompatible implant. The ability to maintain blood temperatures at biologically compatible levels will ultimately allow for the body-wise distribution, and subsequent dissipation, of heat loads with minimum effects on the human physiology. PMID:29094038

Continental-shelf Scale Passive Ocean AcousticWaveguide Remote Sensing of Marine Mammals and other Submerged Objects including Detection, Localization, and Classification

NASA Astrophysics Data System (ADS)

Wang, Delin

In this thesis, we develop the basics of the Passive Ocean Acoustic Waveguide Remote Sensing (POAWRS) technique for the instantaneous continental-shelf scale detection, localization and species classification of marine mammal vocalizations. POAWRS uses a large-aperture, densely sampled coherent hydrophone array system with orders of magnitude higher array gain to enhance signal-to-noise ratios (SNR) by coherent beamforming, enabling detection of underwater acoustic signals either two orders of magnitude more distant in range or lower in SNR than a single hydrophone. The ability to employ coherent spatial processing of signals with the POAWRS technology significantly improves areal coverage, enabling detection of oceanic sound sources over instantaneous wide areas spanning 100 km or more in diameter. The POAWRS approach was applied to analyze marine mammal vocalizations from diverse species received on a 160-element Office Naval Research Five Octave Research Array (ONR-FORA) deployed during their feeding season in Fall 2006 in the Gulf of Maine. The species-dependent temporal-spatial distribution of marine mammal vocalizations and correlation to the prey fish distributions have been determined. Furthermore, the probability of detection regions, source level distributions and pulse compression gains of the vocalization signals from diverse marine mammal species have been estimated. We also develop an approach for enhancing the angular resolution and improving bearing estimates of acoustic signals received on a coherent hydrophone array with multiple-nested uniformly-spaced subapertures, such as the ONR-FORA, by nonuniform array beamforming. Finally we develop a low-cost non-oil-filled towable prototype hydrophone array that consists of eight hydrophone elements with real-time data acquisition and 100 m tow cable. The approach demonstrated here will be applied in the development of a full 160 element POAWRS-type low-cost coherent hydrophone array system in the future.

Distribution and depth of bottom-simulating reflectors in the Nankai subduction margin

NASA Astrophysics Data System (ADS)

Ohde, Akihiro; Otsuka, Hironori; Kioka, Arata; Ashi, Juichiro

2018-04-01

Surface heat flow has been observed to be highly variable in the Nankai subduction margin. This study presents an investigation of local anomalies in surface heat flows on the undulating seafloor in the Nankai subduction margin. We estimate the heat flows from bottom-simulating reflectors (BSRs) marking the lower boundaries of the methane hydrate stability zone and evaluate topographic effects on heat flow via two-dimensional thermal modeling. BSRs have been used to estimate heat flows based on the known stability characteristics of methane hydrates under low-temperature and high-pressure conditions. First, we generate an extensive map of the distribution and subseafloor depths of the BSRs in the Nankai subduction margin. We confirm that BSRs exist at the toe of the accretionary prism and the trough floor of the offshore Tokai region, where BSRs had previously been thought to be absent. Second, we calculate the BSR-derived heat flow and evaluate the associated errors. We conclude that the total uncertainty of the BSR-derived heat flow should be within 25%, considering allowable ranges in the P-wave velocity, which influences the time-to-depth conversion of the BSR position in seismic images, the resultant geothermal gradient, and thermal resistance. Finally, we model a two-dimensional thermal structure by comparing the temperatures at the observed BSR depths with the calculated temperatures at the same depths. The thermal modeling reveals that most local variations in BSR depth over the undulating seafloor can be explained by topographic effects. Those areas that cannot be explained by topographic effects can be mainly attributed to advective fluid flow, regional rapid sedimentation, or erosion. Our spatial distribution of heat flow data provides indispensable basic data for numerical studies of subduction zone modeling to evaluate margin parallel age dependencies of subducting plates.[Figure not available: see fulltext.

Intracorporeal Heat Distribution from Fully Implantable Energy Sources for Mechanical Circulatory Support: A Computational Proof-of-Concept Study.

PubMed

Biasetti, Jacopo; Pustavoitau, Aliaksei; Spazzini, Pier Giorgio

2017-01-01

Mechanical circulatory support devices, such as total artificial hearts and left ventricular assist devices, rely on external energy sources for their continuous operation. Clinically approved power supplies rely on percutaneous cables connecting an external energy source to the implanted device with the associated risk of infections. One alternative, investigated in the 70s and 80s, employs a fully implanted nuclear power source. The heat generated by the nuclear decay can be converted into electricity to power circulatory support devices. Due to the low conversion efficiencies, substantial levels of waste heat are generated and must be dissipated to avoid tissue damage, heat stroke, and death. The present work computationally evaluates the ability of the blood flow in the descending aorta to remove the locally generated waste heat for subsequent full-body distribution and dissipation, with the specific aim of investigating methods for containment of local peak temperatures within physiologically acceptable limits. To this aim, coupled fluid-solid heat transfer computational models of the blood flow in the human aorta and different heat exchanger architectures are developed. Particle tracking is used to evaluate temperature histories of cells passing through the heat exchanger region. The use of the blood flow in the descending aorta as a heat sink proves to be a viable approach for the removal of waste heat loads. With the basic heat exchanger design, blood thermal boundary layer temperatures exceed 50°C, possibly damaging blood cells and proteins. Improved designs of the heat exchanger, with the addition of fins and heat guides, allow for drastically lower blood temperatures, possibly leading to a more biocompatible implant. The ability to maintain blood temperatures at biologically compatible levels will ultimately allow for the body-wise distribution, and subsequent dissipation, of heat loads with minimum effects on the human physiology.

Regional Distribution Shifts Help Explain Local Changes in Wintering Raptor Abundance: Implications for Interpreting Population Trends

PubMed Central

Paprocki, Neil; Heath, Julie A.; Novak, Stephen J.

2014-01-01

Studies of multiple taxa across broad-scales suggest that species distributions are shifting poleward in response to global climate change. Recognizing the influence of distribution shifts on population indices will be an important part of interpreting trends within management units because current practice often assumes that changes in local populations reflect local habitat conditions. However, the individual- and population-level processes that drive distribution shifts may occur across a large, regional scale and have little to do with the habitats within the management unit. We examined the latitudinal center of abundance for the winter distributions of six western North America raptor species using Christmas Bird Counts from 1975–2011. Also, we considered whether population indices within western North America Bird Conservation Regions (BCRs) were explained by distribution shifts. All six raptors had significant poleward shifts in their wintering distributions over time. Rough-legged Hawks (Buteo lagopus) and Golden Eagles (Aquila chrysaetos) showed the fastest rate of change, with 8.41 km yr−1 and 7.74 km yr−1 shifts, respectively. Raptors may be particularly responsive to warming winters because of variable migration tendencies, intraspecific competition for nesting sites that drives males to winter farther north, or both. Overall, 40% of BCR population trend models were improved by incorporating information about wintering distributions; however, support for the effect of distribution on BCR indices varied by species with Rough-legged Hawks showing the most evidence. These results emphasize the importance of understanding how regional distribution shifts influence local-scale population indices. If global climate change is altering distribution patterns, then trends within some management units may not reflect changes in local habitat conditions. The methods used to monitor and manage bird populations within local BCRs will fundamentally change as species experience changes in distribution in response to climate change. PMID:24466253

Observables, gravitational dressing, and obstructions to locality and subsystems

NASA Astrophysics Data System (ADS)

Donnelly, William; Giddings, Steven B.

2016-11-01

Quantum field theory—our basic framework for describing all nongravitational physics—conflicts with general relativity: the latter precludes the standard definition of the former's essential principle of locality, in terms of commuting local observables. We examine this conflict more carefully, by investigating implications of gauge (diffeomorphism) invariance for observables in gravity. We prove a dressing theorem, showing that any operator with nonzero Poincaré charges, and in particular any compactly supported operator, in flat-spacetime quantum field theory must be gravitationally dressed once coupled to gravity, i.e., it must depend on the metric at arbitrarily long distances, and we put lower bounds on this nonlocal dependence. This departure from standard locality occurs in the most severe way possible: in perturbation theory about flat spacetime, at leading order in Newton's constant. The physical observables in a gravitational theory therefore do not organize themselves into local commuting subalgebras: the principle of locality must apparently be reformulated or abandoned, and in fact we lack a clear definition of the coarser and more basic notion of a quantum subsystem of the Universe. We discuss relational approaches to locality based on diffeomorphism-invariant nonlocal operators, and reinforce arguments that any such locality is state-dependent and approximate. We also find limitations to the utility of bilocal diffeomorphism-invariant operators that are considered in cosmological contexts. An appendix provides a concise review of the canonical covariant formalism for gravity, instrumental in the discussion of Poincaré charges and their associated long-range fields.

Space-Time Urban Air Pollution Forecasts

NASA Astrophysics Data System (ADS)

Russo, A.; Trigo, R. M.; Soares, A.

2012-04-01

Air pollution, like other natural phenomena, may be considered a space-time process. However, the simultaneous integration of time and space is not an easy task to perform, due to the existence of different uncertainties levels and data characteristics. In this work we propose a hybrid method that combines geostatistical and neural models to analyze PM10 time series recorded in the urban area of Lisbon (Portugal) for the 2002-2006 period and to produce forecasts. Geostatistical models have been widely used to characterize air pollution in urban areas, where the pollutant sources are considered diffuse, and also to industrial areas with localized emission sources. It should be stressed however that most geostatistical models correspond basically to an interpolation methodology (estimation, simulation) of a set of variables in a spatial or space-time domain. The temporal prediction of a pollutant usually requires knowledge of the main trends and complex patterns of physical dispersion phenomenon. To deal with low resolution problems and to enhance reliability of predictions, an approach based on neural network short term predictions in the monitoring stations which behave as a local conditioner to a fine grid stochastic simulation model is presented here. After the pollutant concentration is predicted for a given time period at the monitoring stations, we can use the local conditional distributions of observed values, given the predicted value for that period, to perform the spatial simulations for the entire area and consequently evaluate the spatial uncertainty of pollutant concentration. To attain this objective, we propose the use of direct sequential simulations with local distributions. With this approach one succeed to predict the space-time distribution of pollutant concentration that accounts for the time prediction uncertainty (reflecting the neural networks efficiency at each local monitoring station) and the spatial uncertainty as revealed by the spatial variograms. The dataset used consists of PM10 concentrations recorded hourly by 12 monitoring stations within the Lisbon's area, for the period 2002-2006. In addition, meteorological data recorded at 3 monitoring stations and boundary layer height (BLH) daily values from the ECMWF (European Centre for Medium Weather Forecast), ERA Interim, were also used. Based on the large-scale standard pressure fields from the ERA40/ECMWF, prevailing circulation patterns at regional scale where determined and used on the construction of the models. After the daily forecasts were produced, the difference between the average maps based on real observations and predicted values were determined and the model's performance was assessed. Based on the analysis of the results, we conclude that the proposed approach shows to be a very promising alternative for urban air quality characterization because of its good results and simplicity of application.

Vortex Rossby Waves in Asymmetric Basic Flow of Typhoons

NASA Astrophysics Data System (ADS)

Wang, Tianju; Zhong, Zhong; Wang, Ju

2018-05-01

Wave ray theory is employed to study features of propagation pathways (rays) of vortex Rossby waves in typhoons with asymmetric basic flow, where the tangential asymmetric basic flow is constructed by superimposing the wavenumber-1 perturbation flow on the symmetric basic flow, and the radial basic flow is derived from the non-divergence equation. Results show that, in a certain distance, the influences of the asymmetry in the basic flow on group velocities and slopes of rays of vortex Rossby waves are mainly concentrated near the radius of maximum wind (RMW), whereas it decreases outside the RMW. The distributions of radial and tangential group velocities of the vortex Rossby waves in the asymmetric basic flow are closely related to the azimuth location of the maximum speed of the asymmetric basic flow, and the importance of radial and tangential basic flow on the group velocities would change with radius. In addition, the stronger asymmetry in the basic flow always corresponds to faster outward energy propagation of vortex Rossby waves. In short, the group velocities, and thereby the wave energy propagation and vortex Rossby wave ray slope in typhoons, would be changed by the asymmetry of the basic flow.

Teaching Intercultural Communication in a Basic Technical Writing Course: A Survey of Our Current Practices and Methods

ERIC Educational Resources Information Center

Matveeva, Natalia

2008-01-01

This research article reports the results of an online survey distributed among technical writing instructors in 2006. The survey aimed to examine how we teach intercultural communication in basic technical writing courses: our current practices and methods. The article discusses three major challenges that instructors may face when teaching about…

Quality in the Basic Grant Delivery System: Volume 2, Corrective Actions.

ERIC Educational Resources Information Center

Advanced Technology, Inc., McLean, VA.

Alternative management procedures are recommended that may lower the rate and magnitude of errors in the award of the Basic Educational Opportunity Grants (BEOGs), or Pell Grants. The recommendations are part of the BEOG quality control project and are based on a review of current (1980-1981) levels, distribution, and significance of error in the…

a Discussion about Effective Ways of Basic Resident Register on GIS

NASA Astrophysics Data System (ADS)

Oku, Naoya; Nonaka, Yasuaki; Ito, Yutaka

2016-06-01

In Japan, each municipality keeps a database of every resident's name, address, gender and date of birth called the Basic Resident Register. If the address information in the register is converted into coordinates by geocoding, it can be plotted as point data on a map. This would enable prompt evacuation from disaster, analysis of distribution of residents, integrating statistics and so on. Further, it can be used for not only analysis of the current situation but also future planning. However, the geographic information system (GIS) incorporating the Basic Resident Register is not widely used in Japan because of the following problems: - Geocoding In order to plot address point data, it is necessary to match the Basic Resident Register and the address dictionary by using the address as a key. The information in the Basic Resident Register does not always match the actual addresses. As the register is based on applications made by residents, the information is prone to errors, such as incorrect Kanji characters. - Security policy on personal information In the register, the address of a resident is linked with his/her name and date of birth. If the information in the Basic Resident Register were to be leaked, it could be used for malicious purposes. This paper proposes solutions to the above problems. The suitable solutions for the problems depend on the purpose of use, thus it is important that the purpose should be defined and a suitable way of the application for each purpose should be chosen. In this paper, we mainly focus on the specific purpose of use: to analyse the distribution of the residents. We provide two solutions to improve the matching rate in geocoding. First, regarding errors in Kanji characters, a correction list of possible errors should be compiled in advance. Second, some sort of analyses such as distribution of residents may not require exactly correct position for the address point. Therefore we set the matching level in order: prefecture, city, town, city-block, house-code, house, and decided to accept up to city-block level for the matching. Moreover, in terms of security policy on personal information, some part of information may not be needed for the distribution analysis. For example, the personal information like resident's name should be excluded from the attribute of address point in order to secure the safety operation of the system.

Classical distributive justice and the European healthcare system: rethinking the foundations of European health care in an age of crises.

PubMed

Bauzon, Stéphane

2015-04-01

The state subvention and distribution of health care not only jeopardize the financial sustainability of the state, but also restrict without a conclusive rational basis the freedom of patients to decide how much health care and of what quality is worth what price. The dominant biopolitics of European health care supports a healthcare monopoly in the hands of the state and the medical profession, which health care should be (re)opened to the patient's authority to deal directly for better basic health care. In a world where it is impossible for all to receive equal access to the best of basic health care, one must critically examine the plausible scope of the authority of the state to limit access to better basic health care. Classical distributive justice affords a basis for re-examining the current European ideology of equality, human dignity, and solidarity that supports healthcare systems with unsustainable egalitarian concerns. © The Author 2015. Published by Oxford University Press, on behalf of the Journal of Medicine and Philosophy Inc. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Unraveling multiple changes in complex climate time series using Bayesian inference

NASA Astrophysics Data System (ADS)

Berner, Nadine; Trauth, Martin H.; Holschneider, Matthias

2016-04-01

Change points in time series are perceived as heterogeneities in the statistical or dynamical characteristics of observations. Unraveling such transitions yields essential information for the understanding of the observed system. The precise detection and basic characterization of underlying changes is therefore of particular importance in environmental sciences. We present a kernel-based Bayesian inference approach to investigate direct as well as indirect climate observations for multiple generic transition events. In order to develop a diagnostic approach designed to capture a variety of natural processes, the basic statistical features of central tendency and dispersion are used to locally approximate a complex time series by a generic transition model. A Bayesian inversion approach is developed to robustly infer on the location and the generic patterns of such a transition. To systematically investigate time series for multiple changes occurring at different temporal scales, the Bayesian inversion is extended to a kernel-based inference approach. By introducing basic kernel measures, the kernel inference results are composed into a proxy probability to a posterior distribution of multiple transitions. Thus, based on a generic transition model a probability expression is derived that is capable to indicate multiple changes within a complex time series. We discuss the method's performance by investigating direct and indirect climate observations. The approach is applied to environmental time series (about 100 a), from the weather station in Tuscaloosa, Alabama, and confirms documented instrumentation changes. Moreover, the approach is used to investigate a set of complex terrigenous dust records from the ODP sites 659, 721/722 and 967 interpreted as climate indicators of the African region of the Plio-Pleistocene period (about 5 Ma). The detailed inference unravels multiple transitions underlying the indirect climate observations coinciding with established global climate events.

Temporal and spatial neural dynamics in the perception of basic emotions from complex scenes

PubMed Central

Costa, Tommaso; Cauda, Franco; Crini, Manuella; Tatu, Mona-Karina; Celeghin, Alessia; de Gelder, Beatrice

2014-01-01

The different temporal dynamics of emotions are critical to understand their evolutionary role in the regulation of interactions with the surrounding environment. Here, we investigated the temporal dynamics underlying the perception of four basic emotions from complex scenes varying in valence and arousal (fear, disgust, happiness and sadness) with the millisecond time resolution of Electroencephalography (EEG). Event-related potentials were computed and each emotion showed a specific temporal profile, as revealed by distinct time segments of significant differences from the neutral scenes. Fear perception elicited significant activity at the earliest time segments, followed by disgust, happiness and sadness. Moreover, fear, disgust and happiness were characterized by two time segments of significant activity, whereas sadness showed only one long-latency time segment of activity. Multidimensional scaling was used to assess the correspondence between neural temporal dynamics and the subjective experience elicited by the four emotions in a subsequent behavioral task. We found a high coherence between these two classes of data, indicating that psychological categories defining emotions have a close correspondence at the brain level in terms of neural temporal dynamics. Finally, we localized the brain regions of time-dependent activity for each emotion and time segment with the low-resolution brain electromagnetic tomography. Fear and disgust showed widely distributed activations, predominantly in the right hemisphere. Happiness activated a number of areas mostly in the left hemisphere, whereas sadness showed a limited number of active areas at late latency. The present findings indicate that the neural signature of basic emotions can emerge as the byproduct of dynamic spatiotemporal brain networks as investigated with millisecond-range resolution, rather than in time-independent areas involved uniquely in the processing one specific emotion. PMID:24214921

40 CFR 1400.6 - Enhanced local access.

Code of Federal Regulations, 2011 CFR

2011-07-01

...); DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION Public Access § 1400.6 Enhanced local access. (a) OCA data elements. Consistent with 42 U.S.C...) OCA information. (1) LEPCs and related local government agencies are authorized and encouraged to...

40 CFR 1400.6 - Enhanced local access.

Code of Federal Regulations, 2012 CFR

2012-07-01

...); DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION Public Access § 1400.6 Enhanced local access. (a) OCA data elements. Consistent with 42 U.S.C...) OCA information. (1) LEPCs and related local government agencies are authorized and encouraged to...

40 CFR 1400.6 - Enhanced local access.

Code of Federal Regulations, 2013 CFR

2013-07-01

...); DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION Public Access § 1400.6 Enhanced local access. (a) OCA data elements. Consistent with 42 U.S.C...) OCA information. (1) LEPCs and related local government agencies are authorized and encouraged to...

40 CFR 1400.6 - Enhanced local access.

Code of Federal Regulations, 2014 CFR

2014-07-01

...); DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION Public Access § 1400.6 Enhanced local access. (a) OCA data elements. Consistent with 42 U.S.C...) OCA information. (1) LEPCs and related local government agencies are authorized and encouraged to...

A local approach for focussed Bayesian fusion

NASA Astrophysics Data System (ADS)

Sander, Jennifer; Heizmann, Michael; Goussev, Igor; Beyerer, Jürgen

2009-04-01

Local Bayesian fusion approaches aim to reduce high storage and computational costs of Bayesian fusion which is separated from fixed modeling assumptions. Using the small world formalism, we argue why this proceeding is conform with Bayesian theory. Then, we concentrate on the realization of local Bayesian fusion by focussing the fusion process solely on local regions that are task relevant with a high probability. The resulting local models correspond then to restricted versions of the original one. In a previous publication, we used bounds for the probability of misleading evidence to show the validity of the pre-evaluation of task specific knowledge and prior information which we perform to build local models. In this paper, we prove the validity of this proceeding using information theoretic arguments. For additional efficiency, local Bayesian fusion can be realized in a distributed manner. Here, several local Bayesian fusion tasks are evaluated and unified after the actual fusion process. For the practical realization of distributed local Bayesian fusion, software agents are predestinated. There is a natural analogy between the resulting agent based architecture and criminal investigations in real life. We show how this analogy can be used to improve the efficiency of distributed local Bayesian fusion additionally. Using a landscape model, we present an experimental study of distributed local Bayesian fusion in the field of reconnaissance, which highlights its high potential.

Influence of the shell thickness and charge distribution on the effective interaction between two like-charged hollow spheres.

PubMed

Angelescu, Daniel G; Caragheorgheopol, Dan

2015-10-14

The mean-force and the potential of the mean force between two like-charged spherical shells were investigated in the salt-free limit using the primitive model and Monte Carlo simulations. Apart from an angular homogeneous distribution, a discrete charge distribution where point charges localized on the shell outer surface followed an icosahedral arrangement was considered. The electrostatic coupling of the model system was altered by the presence of mono-, trivalent counterions or small dendrimers, each one bearing a net charge of 9 e. We analyzed in detail how the shell thickness and the radial and angular distribution of the shell charges influenced the effective interaction between the shells. We found a sequence of the potential of the mean force similar to the like-charged filled spheres, ranging from long-range purely repulsive to short-range purely attractive as the electrostatic coupling increased. Both types of potentials were attenuated and an attractive-to-repulsive transition occurred in the presence of trivalent counterions as a result of (i) thinning the shell or (ii) shifting the shell charge from the outer towards the inner surface. The potential of the mean force became more attractive with the icosahedrally symmetric charge model, and additionally, at least one shell tended to line up with 5-fold symmetry axis along the longest axis of the simulation box at the maximum attraction. The results provided a basic framework of understanding the non-specific electrostatic origin of the agglomeration and long-range assembly of the viral nanoparticles.

On the distribution of species occurrence

USGS Publications Warehouse

Buzas, Martin A.; Koch, Carl F.; Culver, Stephen J.; Sohl, Norman F.

1982-01-01

The distribution of species abundance (number of individuals per species) is well documented. The distribution of species occurrence (number of localities per species), however, has received little attention. This study investigates the distribution of species occurrence for five large data sets. For modern benthic foraminifera, species occurrence is examined from the Atlantic continental margin of North America, where 875 species were recorded 10,017 times at 542 localities, the Gulf of Mexico, where 848 species were recorded 18,007 times at 426 localities, and the Caribbean, where 1,149 species were recorded 6,684 times at 268 localities. For Late Cretaceous molluscs, species occurrence is examined from the Gulf Coast where 716 species were recorded 6,236 times at 166 localities and a subset of this data consisting of 643 species recorded 3,851 times at 86 localities.Logseries and lognormal distributions were fitted to these data sets. In most instances the logseries best predicts the distribution of species occurrence. The lognormal, however, also fits the data fairly well, and, in one instance, better. The use of these distributions allows the prediction of the number of species occurring once, twice, ..., n times.Species abundance data are also available for the molluscan data sets. They indicate that the most abundant species (greatest number of individuals) usually occur most frequently. In all data sets approximately half the species occur four or less times. The probability of noting the presence of rarely occurring species is small, and, consequently, such species must be used with extreme caution in studies requiring knowledge of the distribution of species in space and time.

A Multi Agent-Based Framework for Simulating Household PHEV Distribution and Electric Distribution Network Impact

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cui, Xiaohui; Liu, Cheng; Kim, Hoe Kyoung

2011-01-01

The variation of household attributes such as income, travel distance, age, household member, and education for different residential areas may generate different market penetration rates for plug-in hybrid electric vehicle (PHEV). Residential areas with higher PHEV ownership could increase peak electric demand locally and require utilities to upgrade the electric distribution infrastructure even though the capacity of the regional power grid is under-utilized. Estimating the future PHEV ownership distribution at the residential household level can help us understand the impact of PHEV fleet on power line congestion, transformer overload and other unforeseen problems at the local residential distribution network level.more » It can also help utilities manage the timing of recharging demand to maximize load factors and utilization of existing distribution resources. This paper presents a multi agent-based simulation framework for 1) modeling spatial distribution of PHEV ownership at local residential household level, 2) discovering PHEV hot zones where PHEV ownership may quickly increase in the near future, and 3) estimating the impacts of the increasing PHEV ownership on the local electric distribution network with different charging strategies. In this paper, we use Knox County, TN as a case study to show the simulation results of the agent-based model (ABM) framework. However, the framework can be easily applied to other local areas in the US.« less

Statistical survey on the magnetic structure in magnetotail current sheets

NASA Astrophysics Data System (ADS)

Rong, Z. J.; Wan, W. X.; Shen, C.; Li, X.; Dunlop, M. W.; Petrukovich, A. A.; Zhang, T. L.; Lucek, E.

2011-09-01

On the basis of the multipoint magnetic observations of Cluster in the region 15-19 RE downtail, the magnetic field structure in magnetotail current sheet (CS) center is statistically surveyed. It is found that the By component (in GSM coordinates) is distributed mainly within ∣By∣ < 5nT, while the Bz component is mostly positive and distributes mainly within 1˜10 nT. The plane of the magnetic field lines (MFLs) is mostly vertical to the equatorial plane, with the radius of curvature (Rc) of the MFLs being directed earthward and the binormal (perpendicular to the curvature and magnetic field direction) being directed azimuthally westward. The curvature radius of MFLs reaches a minimum, Rc,min, at the CS center and is larger than the corresponding local half thickness of the neutral sheet, h. Statistically, it is found that the overall surface of the CS, with the normal pointing basically along the south-north direction, can be approximated to be a plane parallel to equatorial plane, although the local CS may be flapping and is frequently tilted to the equatorial plane. The tilted CS (normal inclined to the equatorial plane) is apt to be observed near both flanks and is mainly associated with the slippage of magnetic flux tubes. It is statistically verified that the minimum curvature radius, Rc,min, half thickness of neutral sheet, h, and the slipping angle of MFLs, δ, in the CS satisfies h = Rc,min cosδ. The current density, with a mean strength of 4-8 nA/m2, basically flows azimuthally and tangentially to the surface of the CS, from dawn side to the dusk side. There is an obvious dawn-dusk asymmetry of CS, however. For magnetic local times (MLT) ˜21:00-˜01:00, the CS is relatively thinner; the minimum curvature radius of MFLs, Rc,min (0.6-1 RE) and the half-thickness of neutral sheet, h (0.2-0.4 RE), are relatively smaller, and Bz (3-5 nT) and the minimum magnetic field, Bmin (5-7 nT), are weaker. It is also found that negative Bz has a higher probability of occurrence and the cross-tail current density jY is dominant (2-4 nA/m2) in comparison to those values near both flanks. This implies that magnetic activity, e.g., magnetic reconnection and current disruption, could be triggered more frequently in CS with ˜21:00-˜01:00 MLT. Accordingly, if mapped to the region in the auroral ionosphere, it is expected that substorm onset would be optically observed with higher probability for ˜21:00-˜01:00 MLT, which is well in agreement with statistical observations of auroral substorm onset.

Chained Bell Inequality Experiment with High-Efficiency Measurements

NASA Astrophysics Data System (ADS)

Tan, T. R.; Wan, Y.; Erickson, S.; Bierhorst, P.; Kienzler, D.; Glancy, S.; Knill, E.; Leibfried, D.; Wineland, D. J.

2017-03-01

We report correlation measurements on two 9Be+ ions that violate a chained Bell inequality obeyed by any local-realistic theory. The correlations can be modeled as derived from a mixture of a local-realistic probabilistic distribution and a distribution that violates the inequality. A statistical framework is formulated to quantify the local-realistic fraction allowable in the observed distribution without the fair-sampling or independent-and-identical-distributions assumptions. We exclude models of our experiment whose local-realistic fraction is above 0.327 at the 95% confidence level. This bound is significantly lower than 0.586, the minimum fraction derived from a perfect Clauser-Horne-Shimony-Holt inequality experiment. Furthermore, our data provide a device-independent certification of the deterministically created Bell states.

Distribution of Localized States from Fine Analysis of Electron Spin Resonance Spectra in Organic Transistors

NASA Astrophysics Data System (ADS)

Matsui, Hiroyuki; Mishchenko, Andrei S.; Hasegawa, Tatsuo

2010-02-01

We developed a novel method for obtaining the distribution of trapped carriers over their degree of localization in organic transistors, based on the fine analysis of electron spin resonance spectra at low enough temperatures where all carriers are localized. To apply the method to pentacene thin-film transistors, we proved through continuous wave saturation experiments that all carriers are localized at below 50 K. We analyzed the spectra at 20 K and found that the major groups of traps comprise localized states having wave functions spanning around 1.5 and 5 molecules and a continuous distribution of states with spatial extent in the range between 6 and 20 molecules.

Distribution of localized states from fine analysis of electron spin resonance spectra in organic transistors.

PubMed

Matsui, Hiroyuki; Mishchenko, Andrei S; Hasegawa, Tatsuo

2010-02-05

We developed a novel method for obtaining the distribution of trapped carriers over their degree of localization in organic transistors, based on the fine analysis of electron spin resonance spectra at low enough temperatures where all carriers are localized. To apply the method to pentacene thin-film transistors, we proved through continuous wave saturation experiments that all carriers are localized at below 50 K. We analyzed the spectra at 20 K and found that the major groups of traps comprise localized states having wave functions spanning around 1.5 and 5 molecules and a continuous distribution of states with spatial extent in the range between 6 and 20 molecules.

North American Waterfowl Distributions: Analyzing Long-Term Stability and Case Studies Exploring Potential Drivers of Change

EPA Science Inventory

Knowledge about how species distributions shift through time increases basic ecological understanding, improves species management and conservation, and allows for enhanced predictions about the future. This type of research is difficult to conduct, especially for migratory wate...

10 CFR 431.371 - Submission of data.

Code of Federal Regulations, 2011 CFR

2011-01-01

... transformer, traffic signal module, pedestrian module, and commercial prerinse spray valve shall file a... models. (i) For covered equipment that are subject to standards other than distribution transformers and... spray valves. (ii) For the least efficient basic model of distribution transformer within each “kilovolt...

Comparative study of tool machinery sliding systems; comparison between plane and cylindrical basic shapes

NASA Astrophysics Data System (ADS)

Glăvan, D. O.; Babanatsas, T.; Babanatis Merce, R. M.; Glăvan, A.

2018-01-01

The paper brings in attention the importance that the sliding system of a tool machinery is having in the final precision of the manufacturing. We are basically comparing two type of slides, one constructed with plane surfaces and the other one with circular cross-sections (as known as cylindrical slides), analysing each solution from the point of view of its technology of manufacturing, of the precision that the particular slides are transferring to the tool machinery, cost of production, etc. Special attention is given to demonstrate theoretical and to confirm by experimental works what is happening with the stress distribution in the case of plane slides and cylindrical slides, both in longitudinal and in cross-over sections. Considering the results obtained for the stress distribution in the transversal and longitudinal cross sections, by composing them, we can obtain the stress distribution on the semicircular slide. Based on the results, special solutions for establishing the stress distribution between two surfaces without interact in the contact zone have been developed.

Virtual Collaborative Environments for System of Systems Engineering and Applications for ISAT

NASA Technical Reports Server (NTRS)

Dryer, David A.

2002-01-01

This paper describes an system of systems or metasystems approach and models developed to help prepare engineering organizations for distributed engineering environments. These changes in engineering enterprises include competition in increasingly global environments; new partnering opportunities caused by advances in information and communication technologies, and virtual collaboration issues associated with dispersed teams. To help address challenges and needs in this environment, a framework is proposed that can be customized and adapted for NASA to assist in improved engineering activities conducted in distributed, enhanced engineering environments. The approach is designed to prepare engineers for such distributed collaborative environments by learning and applying e-engineering methods and tools to a real-world engineering development scenario. The approach consists of two phases: an e-engineering basics phase and e-engineering application phase. The e-engineering basics phase addresses skills required for e-engineering. The e-engineering application phase applies these skills in a distributed collaborative environment to system development projects.

Spectral modeling of radiation in combustion systems

NASA Astrophysics Data System (ADS)

Pal, Gopalendu

Radiation calculations are important in combustion due to the high temperatures encountered but has not been studied in sufficient detail in the case of turbulent flames. Radiation calculations for such problems require accurate, robust, and computationally efficient models for the solution of radiative transfer equation (RTE), and spectral properties of radiation. One more layer of complexity is added in predicting the overall heat transfer in turbulent combustion systems due to nonlinear interactions between turbulent fluctuations and radiation. The present work is aimed at the development of finite volume-based high-accuracy thermal radiation modeling, including spectral radiation properties in order to accurately capture turbulence-radiation interactions (TRI) and predict heat transfer in turbulent combustion systems correctly and efficiently. The turbulent fluctuations of temperature and chemical species concentrations have strong effects on spectral radiative intensities, and TRI create a closure problem when the governing partial differential equations are averaged. Recently, several approaches have been proposed to take TRI into account. Among these attempts the most promising approaches are the probability density function (PDF) methods, which can treat nonlinear coupling between turbulence and radiative emission exactly, i.e., "emission TRI". The basic idea of the PDF method is to treat physical variables as random variables and to solve the PDF transport equation stochastically. The actual reacting flow field is represented by a large number of discrete stochastic particles each carrying their own random variable values and evolving with time. The mean value of any function of those random variables, such as the chemical source term, can be evaluated exactly by taking the ensemble average of particles. The local emission term belongs to this class and thus, can be evaluated directly and exactly from particle ensembles. However, the local absorption term involves interactions between the local particle and energy emitted by all other particles and, hence, cannot be obtained from particle ensembles directly. To close the nonlinear coupling between turbulence and absorption, i.e., "absorption TRI", an optically thin fluctuation approximation can be applied to virtually all combustion problems and obtain acceptable accuracy. In the present study a composition-PDF method is applied, in which only the temperature and the species concentrations are treated as random variables. A closely coupled hybrid finite-volume/Monte Carlo scheme is adopted, in which the Monte Carlo method is used to solve the composition-PDF for chemical reactions and the finite volume method is used to solve for the flow field and radiation. Spherical harmonics method-based finite volume solvers (P-1 and P-3) are developed using the data structures of the high fidelity open-source code flow software OpenFOAM. Spectral radiative properties of the participating medium are modeled using full-spectrum k-distribution methods. Advancements of basic k-distribution methods are performed for nongray nonhomogeneous gas- and particulate-phase (soot, fuel droplets, ash, etc.) participating media using multi-scale and multi-group based approaches. These methods achieve close-to benchmark line-by-line (LBL) accuracy in strongly inhomogeneous media at a tiny fraction of LBL's computational cost. A portable spectral module is developed, which includes all the basic to advanced k-distribution methods along with the precompiled accurate and compact k-distribution databases. The P-1 /P-3 RTE solver coupled with the spectral module is used in conjunction with the combined Reynolds-averaged Navier-Stokes (RANS) and composition-PDF-based turbulence-chemistry solver to investigate TRI in multiphase turbulent combustion systems. The combustion solvers developed in this study is employed to simulate several turbulent jet flames, such as Sandia Flame D, and artificial nonsooting and sooting flames derived from Flame D. The effects of combustion chemistry, radiation and TRI on total heat transfer and pollutant (such as NO x) generation are studied for the above flames. The accuracy of the overall combustion solver is assessed by comparing it with the experimental data for Flame D. Comparison of the accuracy and the computational cost among various spectral models and RTE solvers is extensively done on the artificial flames derived from Flame D to demonstrate the necessity of accurate modeling of radiation in combustion problems.

Deletion and site-specific mutagenesis of nucleolin's carboxy GAR domain.

PubMed

Pellar, Gregory J; DiMario, Patrick J

2003-04-01

Vertebrate nucleolin is an abundant RNA-binding protein in the dense fibrillar component of active nucleoli. Nucleolin is modular in composition. Its amino-terminal third contains alternating acidic and basic domains, its middle section contains four consensus RNA-binding domains (cRBDs), and its carboxy-terminus contains a distinctive glycine/arginine-rich (GAR) domain with several RGG motifs. The arginines within these motifs are asymmetrically dimethylated. Several laboratories have shown that the GAR domain is necessary but not sufficient for the efficient localization of nucleolin to nucleoli. We examined the distribution of endogenous fibrillarin, Nopp140, and B23 when full-length and DeltaGAR nucleolin were expressed exogenously as enhanced green fluorescent protein (EGFP)-tagged fusions. Only B23 redistributed when DeltaGAR-EGFP was expressed at moderate to high levels, suggesting an in vivo interaction between nucleolin and B23. Next we substituted all ten arginines within the GAR domain of Chinese hamster ovary (CHO) nucleolin with lysines to test the hypothesis that methylation of the carboxy GAR domain is necessary for the nucleolar association of nucleolin. The lysine-substituted mutant was not an in vitro substrate for the yeast protein methyltransferase, Hmt1p/Rmt1. It was, however, able to associate properly with interphase nucleoli and with interphase pre-nucleolar bodies upon recovery from hypotonic shock. We conclude, therefore, that although the GAR domain is necessary for the efficient localization of nucleolin to nucleoli, methylation of this domain is not required for proper nucleolar localization.

The development of peer educator-based harm reduction programmes in Northern Vietnam.

PubMed

Walsh, Nick; Gibbie, Tania M; Higgs, Peter

2008-03-01

Injecting drug use remains an important risk factor for transmission in Vietnam, with an estimated 50% of the 290 000 people living with HIV/AIDS reporting injecting drug use as a risk factor. Despite this, effective harm reduction interventions are generally lacking. This paper describes the implementation of peer-based harm reduction programmes in two rural provinces of Vietnam. Peer educators were trained in basic HIV prevention, including harm reduction. After significant preparation work with the Provincial AIDS Committees of Bac Giang and Thanh Hoa and other relevant national, provincial and local authorities, the interventions were commenced. Harm reduction interventions were delivered through outreach as well as on-site. This included needle and syringe distribution and collection. Community advocacy occurred throughout the life of the project. Local authorities and peers believed that while there was a general reduction in stigma and discrimination, legal barriers associated particularly with the carrying of injecting equipment remained. This impacted upon the ability of peer educators to work with their clients. Peer-based delivery of harm reduction intervention is acceptable. Harm reduction interventions, including needle and syringe programmes, are feasible and acceptable in these two rural Vietnamese provinces. Community acceptance and uptake of these interventions is key to successful expansion across the region. Active participation by families of drug users seems crucial. This initiative demonstrates that despite a difficult policy environment, peer-delivered needle and syringe programmes are feasible within a rural Asian environment as long as there is adequate local political and community support.

Design Improvements in Underground Watering System for Small Local Farming Industries

NASA Astrophysics Data System (ADS)

Ariff, T. F.; Tukiman, N. H. A.; Bahar, R.

2016-02-01

The implementation of underground watering system is basically to supply crops with enough quantities of water. In Malaysia, most farming industries use sprinkler irrigation system. The water is only distributed over the surface whilst the roots actually need water the most. Thus, this research is conducted to design the improvements of watering system for small local farming industries by using underground watering system. Design improvements of the watering system had been done using CATIA software. The design had been fabricated using rapid prototyping/3D printer, tested and evaluated by conducting experiments. Four different plants were prepared and labelled as Plant A, Plant B, Plant C, and Plant D. Plant A and Plant C were not be equipped with the underground watering device while Plant B and Plant D were equipped with the device. The growth of every plant is measured in terms of height, number of newly grown leaves, number of flowers and number of fruits for the duration of 60 days. The plant equipped with the device has the quickest growth measurement (59.68%), continued to produce new leaves rapidly (89.20%), and produced the most number of flowers (19 flowers) and fruits (15 fruits) when compared with the plants without the underground watering device. The difference in growth development is very significant. Therefore, the underground watering system does have a positive impact in nourishing the plant from the root efficiently and can be used productively in small local farming industries.

THE IMPACT OF STELLAR FEEDBACK ON THE STRUCTURE, SIZE, AND MORPHOLOGY OF GALAXIES IN MILKY-WAY-SIZED DARK MATTER HALOS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agertz, Oscar; Kravtsov, Andrey V., E-mail: o.agertz@surrey.ac.uk

We use cosmological zoom-in simulations of galaxy formation in a Milky-Way-sized halo started from identical initial conditions to investigate the evolution of galaxy sizes, baryon fractions, morphologies, and angular momenta in runs with different parameters of the star formation–feedback cycle. Our fiducial model with a high local star formation efficiency, which results in efficient feedback, produces a realistic late-type galaxy that matches the evolution of basic properties of late-type galaxies: stellar mass, disk size, morphology dominated by a kinematically cold disk, stellar and gas surface density profiles, and specific angular momentum. We argue that feedback’s role in this success ismore » twofold: (1) removal of low angular momentum gas, and (2) maintaining a low disk-to-halo mass fraction, which suppresses disk instabilities that lead to angular momentum redistribution and a central concentration of baryons. However, our model with a low local star formation efficiency, but large energy input per supernova, chosen to produce a galaxy with a similar star formation history as our fiducial model, leads to a highly irregular galaxy with no kinematically cold component, overly extended stellar distribution, and low angular momentum. This indicates that only when feedback is allowed to become vigorous via locally efficient star formation in dense cold gas do resulting galaxy sizes, gas/stellar surface density profiles, and stellar disk angular momenta agree with observed z = 0 galaxies.« less

Impact of boundaries on velocity profiles in bubble rafts.

PubMed

Wang, Yuhong; Krishan, Kapilanjan; Dennin, Michael

2006-03-01

Under conditions of sufficiently slow flow, foams, colloids, granular matter, and various pastes have been observed to exhibit shear localization, i.e., regions of flow coexisting with regions of solidlike behavior. The details of such shear localization can vary depending on the system being studied. A number of the systems of interest are confined so as to be quasi two-dimensional, and an important issue in these systems is the role of the confining boundaries. For foams, three basic systems have been studied with very different boundary conditions: Hele-Shaw cells (bubbles confined between two solid plates); bubble rafts (a single layer of bubbles freely floating on a surface of water); and confined bubble rafts (bubbles confined between the surface of water below and a glass plate on top). Often, it is assumed that the impact of the boundaries is not significant in the "quasistatic limit," i.e., when externally imposed rates of strain are sufficiently smaller than internal kinematic relaxation times. In this paper, we directly test this assumption for rates of strain ranging from 10(-3) to 10(-2) s(-1). This corresponds to the quoted rate of strain that had been used in a number of previous experiments. It is found that the top plate dramatically alters both the velocity profile and the distribution of nonlinear rearrangements, even at these slow rates of strain. When a top is present, the flow is localized to a narrow band near the wall, and without a top, there is flow throughout the system.

Columbia/Willamette Skill Builders Consortium. Final Performance Report. Appendix 5B Anodizing Inc. (Aluminum Extrusion Manufacturing). Basic Measurement Math. Instructors' Reports and Sample Curriculum Materials.

ERIC Educational Resources Information Center

Taylor, Marjorie; And Others

Anodizing, Inc., Teamsters Local 162, and Mt. Hood Community College (Oregon) developed a workplace literacy program for workers at Anodizing. These workers did not have the basic skill competencies to benefit from company training efforts in statistical process control and quality assurance and were not able to advance to lead and supervisory…

An Institute to Prepare Local Urban Adult Basic Education Administrators and Teachers to Become ABE Teacher Trainers: June 1, 1971-May 31, 1972. Final Report.

ERIC Educational Resources Information Center

Pumerantz, Phillip

The 12-month Federally funded project at the University of Bridgeport, Connecticut was designed to prepare adult basic education (ABE) administrators and teachers (serving urban Puerto Ricans, blacks, and whites) to become teacher trainers. Focus was on building a multi-regional teacher capability in ABE through teacher training models. Phase one…

Local operators in kinetic wealth distribution

NASA Astrophysics Data System (ADS)

Andrecut, M.

2016-05-01

The statistical mechanics approach to wealth distribution is based on the conservative kinetic multi-agent model for money exchange, where the local interaction rule between the agents is analogous to the elastic particle scattering process. Here, we discuss the role of a class of conservative local operators, and we show that, depending on the values of their parameters, they can be used to generate all the relevant distributions. We also show numerically that in order to generate the power-law tail, an heterogeneous risk aversion model is required. By changing the parameters of these operators, one can also fine tune the resulting distributions in order to provide support for the emergence of a more egalitarian wealth distribution.

Alzheimer's Disease Can Spare Local Metacognition Despite Global Anosognosia: Revisiting the Confidence-Accuracy Relationship in Episodic Memory

ERIC Educational Resources Information Center

Gallo, David A.; Cramer, Stefanie J.; Wong, Jessica T.; Bennett, David A.

2012-01-01

Alzheimer's disease (AD) can impair metacognition in addition to more basic cognitive functions like memory. However, while global metacognitive inaccuracies are well documented (i.e., low deficit awareness, or anosognosia), the evidence is mixed regarding the effects of AD on local or task-based metacognitive judgments. Here we investigated local…

Industry-Education Partnership Councils. A Comprehensive Handbook for Local Action To Improve Industry-Education Cooperation.

ERIC Educational Resources Information Center

Industry Education Council (Hamilton-Wentworth), Hamilton (Ontario).

This handbook provides basic information about forming and operating an industry-education partnership council (IEPC). Purpose of the handbook is to enable interested communities to replicate the model IEPC and develop strong local industry-education alliances. Part I is an introduction to industry-education partnerships. Part II focuses on…

How to Gather Information on Community Needs and Funding Sources. Resources for Rural Development Series: Handbook No. 1.

ERIC Educational Resources Information Center

Cohen, John M.; Marshall, Terry

One of a series designed to aid community leaders, cooperative extension agents, local government officials, and others in their efforts to gain external resources needed to support local efforts in rural development, this handbook addresses three basic problem areas: gathering information on rural development needs of a community; locating…

Use of Local Health Department Websites: A Study of E-Government Adoption and Diffusion

ERIC Educational Resources Information Center

Aaltonen, Pamela Massie

2013-01-01

Two distinct but converging activities have the potential to alter the way local public health departments conduct business. These activities are the emergence of e-government and the addition of preparedness as a basic function of the public health system. Preparedness implies timely collaboration with government entities, community partners and…

Reaching the Least Educated. 130 Local ABE Directors Tell How. Pennsylvania's Handbook on Recruitment.

ERIC Educational Resources Information Center

Madeira, Eugene L.

Based on the experience of 130 local adult basic education (ABE) directors in Pennsylvania, this guide presents suggestions for recruiting the least educated adults into ABE programs. Following an introduction that defines ABE and examines whose responsibility ABE is, the guide is divided into 12 chapters. Each of the chapters develops one…

Low- and Moderate-Income Solar Policy Basics | State, Local, and Tribal

Science.gov Websites

scores, which can make attaining a loan for solar investments difficult. Even in cases where loans are translate into having less control over decisions about rooftop solar and utilities. Even in cases where LMI program) to increase local solar deployment. In other cases, CDFIs and CDEs can directly facilitate

Improving Basic Programs Operated by Local Education Agencies. Policy Guidance for Title I, Part A.

ERIC Educational Resources Information Center

Office of Elementary and Secondary Education (ED), Washington, DC. Compensatory Education Programs.

Title I of the Elementary and Secondary Education Act (ESEA) of 1965 (with its reauthorizations) is designed to help disadvantaged children meet challenging content and performance standards. Part A of Title I provides financial assistance through State educational agencies to local education agencies (LEAs) to meet the educational needs of…

Random Fields

NASA Astrophysics Data System (ADS)

Vanmarcke, Erik

1983-03-01

Random variation over space and time is one of the few attributes that might safely be predicted as characterizing almost any given complex system. Random fields or "distributed disorder systems" confront astronomers, physicists, geologists, meteorologists, biologists, and other natural scientists. They appear in the artifacts developed by electrical, mechanical, civil, and other engineers. They even underlie the processes of social and economic change. The purpose of this book is to bring together existing and new methodologies of random field theory and indicate how they can be applied to these diverse areas where a "deterministic treatment is inefficient and conventional statistics insufficient." Many new results and methods are included. After outlining the extent and characteristics of the random field approach, the book reviews the classical theory of multidimensional random processes and introduces basic probability concepts and methods in the random field context. It next gives a concise amount of the second-order analysis of homogeneous random fields, in both the space-time domain and the wave number-frequency domain. This is followed by a chapter on spectral moments and related measures of disorder and on level excursions and extremes of Gaussian and related random fields. After developing a new framework of analysis based on local averages of one-, two-, and n-dimensional processes, the book concludes with a chapter discussing ramifications in the important areas of estimation, prediction, and control. The mathematical prerequisite has been held to basic college-level calculus.

Design of the National Trends Network for monitoring the chemistry of atmospheric precipitation

USGS Publications Warehouse

Robertson, J.K.; Wilson, J.W.

1985-01-01

Long-term monitoring (10 years minimum) of the chemistry of wet deposition will be conducted at National Trends Network (NTN) sites across the United States. Precipitation samples will be collected at sites that represent broad regional characteristics. Design of the NTN considered four basic elements during construction of a model to distribute 50, 75, 100, 125 or 150 sites. The modeling oriented design was supplemented with guidance developed during the course of the site selection process. Ultimately, a network of 151 sites was proposed. The basic elements of the design are: (1) Assurance that all areas of the country are represented in the network on the basis of regional ecological properties (96 sites); (2) Placement of additional sites east of the Rocky Mountains to better define high deposition gradients (27 sites); (3) Placement of sites to assure that potentially sensitive regions are represented (15 sites); (4) Placement of sites to allow for other considerations, such as urban area effects (5 sites), intercomparison with Canada (3 sites), and apparent disparities in regional coverage (5 sites). Site selection stressed areas away from urban centers, large point sources, or ocean influences. Local factors, such as stable land ownership, nearby small emission sources (about 10 km), and close-by roads and fireplaces (about 0.5 km) were also considered. All proposed sites will be visited as part of the second phase of the study.

7 CFR 1735.12 - Nonduplication.

Code of Federal Regulations, 2010 CFR

2010-01-01

... GENERAL POLICIES, TYPES OF LOANS, LOAN REQUIREMENTS-TELECOMMUNICATIONS PROGRAM Loan Purposes and Basic... of existing wireline local exchange service or similar fixed-station voice service. RUS may finance...

Inhalers and nebulizers: basic principles and preliminary measurements

NASA Astrophysics Data System (ADS)

Misik, Ondrej; Lizal, Frantisek; Asl, Vahid Farhikhteh; Belka, Miloslav; Jedelsky, Jan; Elcner, Jakub; Jicha, Miroslav

2018-06-01

Inhalers are hand-held devices which are used for administration of therapeutic aerosols via inhalation. Nebulizers are larger devices serving for home and hospital care using inhaled medication. This contribution describes the basic principles of dispersion of aerosol particles used in various types of inhalers and nebulizers, and lists the basic physical mechanisms contributing to the deposition of inhaled particles in the human airways. The second part of this article presents experimental setup, methodology and preliminary results of particle size distributions produced by several selected inhalers and nebulizers.

Plasma Electrolyte Distributions in Humans-Normal or Skewed?

PubMed

Feldman, Mark; Dickson, Beverly

2017-11-01

It is widely believed that plasma electrolyte levels are normally distributed. Statistical tests and calculations using plasma electrolyte data are often reported based on this assumption of normality. Examples include t tests, analysis of variance, correlations and confidence intervals. The purpose of our study was to determine whether plasma sodium (Na + ), potassium (K + ), chloride (Cl - ) and bicarbonate [Formula: see text] distributions are indeed normally distributed. We analyzed plasma electrolyte data from 237 consecutive adults (137 women and 100 men) who had normal results on a standard basic metabolic panel which included plasma electrolyte measurements. The skewness of each distribution (as a measure of its asymmetry) was compared to the zero skewness of a normal (Gaussian) distribution. The plasma Na + distribution was skewed slightly to the right, but the skew was not significantly different from zero skew. The plasma Cl - distribution was skewed slightly to the left, but again the skew was not significantly different from zero skew. On the contrary, both the plasma K + and [Formula: see text] distributions were significantly skewed to the right (P < 0.01 zero skew). There was also a suggestion from examining frequency distribution curves that K + and [Formula: see text] distributions were bimodal. In adults with a normal basic metabolic panel, plasma potassium and bicarbonate levels are not normally distributed and may be bimodal. Thus, statistical methods to evaluate these 2 plasma electrolytes should be nonparametric tests and not parametric ones that require a normal distribution. Copyright © 2017 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

[Distribution characteristics of basic syndromes of chronic functional constipation and its related factors analysis].

PubMed

Zhao, Lei; Liao, Xiu-jun; Yang, Guan-gen; Mao, Wei-ming; Zhang, Xiu-feng; Deng, Qun; Wu, Wen-jing

2014-10-01

To explore the distribution characteristics of basic syndromes and its related factors in patients with chronic functional constipation (CFC). The complete data of 538 patients with CFC were collected and initial database was established with Epidata 3. 0. TCM syndrome typing was performed. The distribution characteristics of basic syndromes were analyzed using SPSS 17. 0 Software. The univariate and multivariate Logistic regression analyses were performed with SPSS 17. 0 Software to determine basic syndrome related factors such as age, engaged professionals, sleep quality, depression, mental stress, interpersonal relations, work fatigue, stimulating beverage, exercise conditions, Western medicine type of constipation, and so on. The TCM syndrome frequency of CFC patients was sequenced from high to low as qi deficiency syndrome (380 cases, 70.6%), qi stagnation syndrome (337 cases, 62.6%), blood deficiency syndrome (234 cases, 43.5%), yin deficiency syndrome (220 cases, 40.9%), yang deficiency syndrome (197 cases, 36.6%), and others(58 cases, 10. 8%) . Most patients were complicated with complex syndromes, and the most common complex syndromes were qi deficiency complicated qi stagnation syndrome (275 cases, 51.1%) and qi deficiency complicated blood deficiency syndrome (222 cases, 41.3%). Aging, work fatigue, and exercise conditions were main related factors for qi deficiency syndrome (P <0. 01, P <0. 05). Poor emotional (depression and anxiety tendencies), mental stress, interpersonal relations, defecation barriers constipation were main related factors for qi stagnation syndrome (P <0.01). Sleep quality and poor emotional (depression and anxiety tendencies) were main related factors for blood deficiency syndrome (P <0. 01, P < 0.05). Stimulating beverages were main related factor for yin deficiency syndrome (P <0.05). Engaged in mental work and slow transit constipation were main related factors for yang deficiency syndrome (P < 0. 01, P <0. 05). CFC is featured as complex syndromes. The most common complex syndromes were qi deficiency complicated qi stagnation syndrome and qi deficiency complicated blood deficiency syndrome. Basic syndrome related factors such as age, engaged professionals, sleep quality, poor emotional (depression and anxiety tendencies), mental stress, interpersonal relations, work fatigue, stimulating beverage, exercise conditions, Western medicine type of constipation were associated with the distribution of CFC syndromes.

Distributed Localization of Active Transmitters in a Wireless Sensor Network

DTIC Science & Technology

2012-03-01

Distributed Localization of Active Transmitters in a Wireless Sensor Network THESIS Oba L. Vincent, 2nd Lieutenant, USAF AFIT/GE/ENG/12-41 DEPARTMENT...protection in the United States. AFIT/GE/ENG/12-41 Distributed Localization of Active Transmitters in a Wireless Sensor Network THESIS Presented to the...Transmitters in a Wireless Sensor Network Oba L. Vincent, B.S.E.E. 2nd Lieutenant, USAF Approved: /signed/ 29 Feb 2012 Maj. Mark D. Silvius, Ph.D. (Chairman

Distributed Power Allocation for Wireless Sensor Network Localization: A Potential Game Approach.

PubMed

Ke, Mingxing; Li, Ding; Tian, Shiwei; Zhang, Yuli; Tong, Kaixiang; Xu, Yuhua

2018-05-08

The problem of distributed power allocation in wireless sensor network (WSN) localization systems is investigated in this paper, using the game theoretic approach. Existing research focuses on the minimization of the localization errors of individual agent nodes over all anchor nodes subject to power budgets. When the service area and the distribution of target nodes are considered, finding the optimal trade-off between localization accuracy and power consumption is a new critical task. To cope with this issue, we propose a power allocation game where each anchor node minimizes the square position error bound (SPEB) of the service area penalized by its individual power. Meanwhile, it is proven that the power allocation game is an exact potential game which has one pure Nash equilibrium (NE) at least. In addition, we also prove the existence of an ϵ -equilibrium point, which is a refinement of NE and the better response dynamic approach can reach the end solution. Analytical and simulation results demonstrate that: (i) when prior distribution information is available, the proposed strategies have better localization accuracy than the uniform strategies; (ii) when prior distribution information is unknown, the performance of the proposed strategies outperforms power management strategies based on the second-order cone program (SOCP) for particular agent nodes after obtaining the estimated distribution of agent nodes. In addition, proposed strategies also provide an instructional trade-off between power consumption and localization accuracy.

Functional analysis of the C-terminal region of human adenovirus E1A reveals a misidentified nuclear localization signal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cohen, Michael J.; King, Cason R.; Dikeakos, Jimmy D.

The immortalizing function of the human adenovirus 5 E1A oncoprotein requires efficient localization to the nucleus. In 1987, a consensus monopartite nuclear localization sequence (NLS) was identified at the C-terminus of E1A. Since that time, various experiments have suggested that other regions of E1A influence nuclear import. In addition, a novel bipartite NLS was recently predicted at the C-terminal region of E1A in silico. In this study, we used immunofluorescence microscopy and co-immunoprecipitation analysis with importin-α to verify that full nuclear localization of E1A requires the well characterized NLS spanning residues 285–289, as well as a second basic patch situatedmore » between residues 258 and 263 ({sup 258}RVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP{sup 289}). Thus, the originally described NLS located at the C-terminus of E1A is actually a bipartite signal, which had been misidentified in the existing literature as a monopartite signal, altering our understanding of one of the oldest documented NLSs. - Highlights: • Human adenovirus E1A is localized to the nucleus. • The C-terminus of E1A contains a bipartite nuclear localization signal (NLS). • This signal was previously misidentified to be a monopartite NLS. • Key basic amino acid residues within this sequence are highly conserved.« less

Optical distribution of local oscillators in future telecommunication satellite payloads

NASA Astrophysics Data System (ADS)

Benazet, Benoît; Sotom, Michel; Maignan, Michel; Berthon, Jacques

2017-11-01

The distribution of high spectral purity reference signals over optical fibre in future telecommunication satellite payloads is presented. Several types of applications are considered, including the distribution of a reference frequency at 10 MHz (Ultra-Stable Reference Oscillator) as well as the distribution of a radiofrequency oscillator around 800 MHz (Master Local Oscillator). The results of both experimental and theoretical studies are reported. In order to meet phase noise requirements for the USRO distribution, the use of an optimised receiver circuit based on an optically synchronised oscillator is investigated. Finally, the optical distribution of microwave local oscillators at frequencies exceeding 20 GHz is described. Such a scheme paves the way to more advanced sub-systems involving optical frequency-mixing and optical transmission of microwave signals, with applications to multiple-beam active antennas.

Advertising, a Distributive Education Manual and Answer Book.

ERIC Educational Resources Information Center

Martin, Charles H.; Cyrus, Cinda L.

This revised manual for individualized instruction of distributive education trainees at the high school or junior college level in basic advertising and sales promotion activities includes 15 self-study assignments, teaching suggestions, and a bibliography. Together with a separate answer key, each assignment provides student questions and…

An approach for heterogeneous and loosely coupled geospatial data distributed computing

NASA Astrophysics Data System (ADS)

Chen, Bin; Huang, Fengru; Fang, Yu; Huang, Zhou; Lin, Hui

2010-07-01

Most GIS (Geographic Information System) applications tend to have heterogeneous and autonomous geospatial information resources, and the availability of these local resources is unpredictable and dynamic under a distributed computing environment. In order to make use of these local resources together to solve larger geospatial information processing problems that are related to an overall situation, in this paper, with the support of peer-to-peer computing technologies, we propose a geospatial data distributed computing mechanism that involves loosely coupled geospatial resource directories and a term named as Equivalent Distributed Program of global geospatial queries to solve geospatial distributed computing problems under heterogeneous GIS environments. First, a geospatial query process schema for distributed computing as well as a method for equivalent transformation from a global geospatial query to distributed local queries at SQL (Structured Query Language) level to solve the coordinating problem among heterogeneous resources are presented. Second, peer-to-peer technologies are used to maintain a loosely coupled network environment that consists of autonomous geospatial information resources, thus to achieve decentralized and consistent synchronization among global geospatial resource directories, and to carry out distributed transaction management of local queries. Finally, based on the developed prototype system, example applications of simple and complex geospatial data distributed queries are presented to illustrate the procedure of global geospatial information processing.

Transduction of NeuroD2 protein induced neural cell differentiation.

PubMed

Noda, Tomohide; Kawamura, Ryuzo; Funabashi, Hisakage; Mie, Masayasu; Kobatake, Eiry

2006-11-01

NeuroD2, one of the neurospecific basic helix-loop-helix transcription factors, has the ability to induce neural differentiation in undifferentiated cells. In this paper, we show that transduction of NeuroD2 protein induced mouse neuroblastoma cell line N1E-115 into neural differentiation. NeuroD2 has two basic-rich domains, one is nuclear localization signal (NLS) and the other is basic region of basic helix-loop-helix (basic). We constructed some mutants of NeuroD2, ND2(Delta100-115) (lack of NLS), ND2(Delta123-134) (lack of basic) and ND2(Delta100-134) (lack of both NLS and basic) for transduction experiments. Using these proteins, we have shown that NLS region of NeuroD2 plays a role of protein transduction. Continuous addition of NeuroD2 protein resulted in N1E-115 cells adopting neural morphology after 4 days and Tau mRNA expression was increased. These results suggest that neural differentiation can be induced by direct addition of NeuroD2 protein.

Fault and event tree analyses for process systems risk analysis: uncertainty handling formulations.

PubMed

Ferdous, Refaul; Khan, Faisal; Sadiq, Rehan; Amyotte, Paul; Veitch, Brian

2011-01-01

Quantitative risk analysis (QRA) is a systematic approach for evaluating likelihood, consequences, and risk of adverse events. QRA based on event (ETA) and fault tree analyses (FTA) employs two basic assumptions. The first assumption is related to likelihood values of input events, and the second assumption is regarding interdependence among the events (for ETA) or basic events (for FTA). Traditionally, FTA and ETA both use crisp probabilities; however, to deal with uncertainties, the probability distributions of input event likelihoods are assumed. These probability distributions are often hard to come by and even if available, they are subject to incompleteness (partial ignorance) and imprecision. Furthermore, both FTA and ETA assume that events (or basic events) are independent. In practice, these two assumptions are often unrealistic. This article focuses on handling uncertainty in a QRA framework of a process system. Fuzzy set theory and evidence theory are used to describe the uncertainties in the input event likelihoods. A method based on a dependency coefficient is used to express interdependencies of events (or basic events) in ETA and FTA. To demonstrate the approach, two case studies are discussed. © 2010 Society for Risk Analysis.

Life histories predict genetic diversity and population structure within three species of octopus targeted by small-scale fisheries in Northwest Mexico.

PubMed

Domínguez-Contreras, José F; Munguia-Vega, Adrian; Ceballos-Vázquez, Bertha P; Arellano-Martínez, Marcial; García-Rodríguez, Francisco J; Culver, Melanie; Reyes-Bonilla, Hector

2018-01-01

The fishery for octopus in Northwest Mexico has increased to over 2,000 tons annually, but to date the specific composition of the catch has been ignored. With at least three main species targeted by artisanal fisheries in the region with distinct life histories, the lack of basic biological information about the distribution, metapopulation size and structure of each species could impede effective fisheries management to avoid overexploitation. We tested if different life histories of three species of octopus could help predict observed patterns of genetic diversity, population dynamics, structure and connectivity and how this information could be relevant to the sustainable management of the fishery. We sequenced two mitochondrial genes and genotyped seven nuclear microsatellite loci to identify the distribution of each species in 20 locations from the Gulf of California and the west coast of the Baja California peninsula. We tested five hypotheses derived from population genetic theory based on differences in the fecundity and dispersal potential for each species. We discovered that Octopus bimaculoides with low fecundity and direct development (without a planktonic phase) had lower average effective population size and genetic diversity, but higher levels of kinship, population structure, and richness of private alleles, than the other two species. These features indicated limited dispersal and high local recruitment. In contrast, O. bimaculatus and O. hubbsorum with higher fecundity and planktonic phase as paralarvae had higher effective population size and genetic diversity, and overall lower kinship and population structure than O. bimaculoides . These observations supported higher levels of gene flow over a larger geographical scale. O. bimaculatus with the longest planktonic paralarval duration and therefore larger dispersal potential had differences in the calculated parameters possibly associated with increased connectivity. We propose O. bimaculoides is more susceptible to over exploitation of small, isolated populations and could have longer recovery times than the other two species. This species may benefit from distinct fishery management within each local population. O. bimaculatus and O. hubbsorum may benefit from fishery management that takes into account metapopulation structure over larger geographic scales and the directionality and magnitude of larval dispersal driven by ocean currents and population connectivity among individuals of each locality. The distribution of each species and variations in their reproductive phenology is also important to consider when establishing marine reserves or seasonal fishing closures.

Nuclear localization of coactivator RAC3 is mediated by a bipartite NLS and importin {alpha}3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yeung, Percy Luk; Zhang, Aihua; Chen, J. Don

2006-09-15

The nuclear receptor coactivator RAC3 (also known as SRC-3/ACTR/AIB1/p/CIP/TRAM-1) belongs to the p160 coactivator family, which are involved in several physiological processes and diseases. Here we have investigated how RAC3 is translocated into the nucleus and show that it is mediated through a bipartite NLS and importin {alpha}3. This bipartite NLS is located within the conserved bHLH domain, and its mutation abolished nuclear localization. The NLS is also sufficient to cause nuclear import of EGFP, and the activity requires basic amino acids within the NLS. RAC3 binds strongly to importin {alpha}3, which also depends on the basic amino acids. Functionally,more » RAC3 cytoplasmic mutant loses its ability to enhance transcription, suggesting that nuclear localization is essential for coactivator function. Together, these results reveal a previous unknown mechanism for nuclear translocation of p160 coactivators and a critical function of the conserved bHLH within the coactivator.« less

[A severe epicutaneous test reaction to the bufexamac in a hemorrhoidal therapeutic preparation].

PubMed

Bauer, A; Greif, C; Gebhardt, M; Elsner, P

1999-10-08

A 49-year-old woman presented with acute perianal vesicular/bullous contact dermatitis. Other areas were over the trunk, face, neck and wrists. She reported occasional application of an ointment (Mastu S) to treat her hemorrhoids. Patch tests (basic series, anal block, own ointment, local anesthetic, cosmetics) provoked strong vesicular and bullous reactions of persisting crescendo type, spreading far beyond the site of application, to Bufexamac, to a derivative of hydroxxamine acid, and to local applied ointment with mild or moderate antiinflammatory action. A week after the patch tests there was a flare-up of the previous foci of dermatitis. These reactions subsided two days later after intravenous injection of prednisolone. The skin lesions healed after rapid reduction of the systemic treatment and local application of corticosteroids, bathing with tanning substances and basic preparations. While Bufexamac is not absorbed when applied rectally, perianal contamination may not be avoidable on intra-anal application and can produce sensitization.

A simple molecular orbital treatment of current distributions in quantum transport through molecular junctions

NASA Astrophysics Data System (ADS)

Jhan, Sin-Mu; Jin, Bih-Yaw

2017-11-01

A simple molecular orbital treatment of local current distributions inside single molecular junctions is developed in this paper. Using the first-order perturbation theory and nonequilibrium Green's function techniques in the framework of Hückel theory, we show that the leading contributions to local current distributions are directly proportional to the off-diagonal elements of transition density matrices. Under the orbital approximation, the major contributions to local currents come from a few dominant molecular orbital pairs which are mixed by the interactions between the molecule and electrodes. A few simple molecular junctions consisting of single- and multi-ring conjugated systems are used to demonstrate that local current distributions inside molecular junctions can be decomposed by partial sums of a few leading contributing transition density matrices.

Applying a New Model for Sharing Population Health Data to National Syndromic Influenza Surveillance: DiSTRIBuTE Project Proof of Concept, 2006 to 2009.

PubMed

Olson, Donald R; Paladini, Marc; Lober, William B; Buckeridge, David L

2011-08-02

The Distributed Surveillance Taskforce for Real-time Influenza Burden Tracking and Evaluation (DiSTRIBuTE) project began as a pilot effort initiated by the International Society for Disease Surveillance (ISDS) in autumn 2006 to create a collaborative electronic emergency department (ED) syndromic influenza-like illness (ILI) surveillance network based on existing state and local systems and expertise. DiSTRIBuTE brought together health departments that were interested in: 1) sharing aggregate level data; 2) maintaining jurisdictional control; 3) minimizing barriers to participation; and 4) leveraging the flexibility of local systems to create a dynamic and collaborative surveillance network. This approach was in contrast to the prevailing paradigm for surveillance where record level information was collected, stored and analyzed centrally. The DiSTRIBuTE project was created with a distributed design, where individual level data remained local and only summarized, stratified counts were reported centrally, thus minimizing privacy risks. The project was responsive to federal mandates to improve integration of federal, state, and local biosurveillance capabilities. During the proof of concept phase, 2006 to 2009, ten jurisdictions from across North America sent ISDS on a daily to weekly basis year-round, aggregated data by day, stratified by local ILI syndrome, age-group and region. During this period, data from participating U.S. state or local health departments captured over 13% of all ED visits nationwide. The initiative focused on state and local health department trust, expertise, and control. Morbidity trends observed in DiSTRIBuTE were highly correlated with other influenza surveillance measures. With the emergence of novel A/H1N1 influenza in the spring of 2009, the project was used to support information sharing and ad hoc querying at the state and local level. In the fall of 2009, through a broadly collaborative effort, the project was expanded to enhance electronic ED surveillance nationwide.

Empirical mode decomposition apparatus, method and article of manufacture for analyzing biological signals and performing curve fitting

NASA Technical Reports Server (NTRS)

Huang, Norden E. (Inventor)

2004-01-01

A computer implemented physical signal analysis method includes four basic steps and the associated presentation techniques of the results. The first step is a computer implemented Empirical Mode Decomposition that extracts a collection of Intrinsic Mode Functions (IMF) from nonlinear, nonstationary physical signals. The decomposition is based on the direct extraction of the energy associated with various intrinsic time scales in the physical signal. Expressed in the IMF's, they have well-behaved Hilbert Transforms from which instantaneous frequencies can be calculated. The second step is the Hilbert Transform which produces a Hilbert Spectrum. Thus, the invention can localize any event on the time as well as the frequency axis. The decomposition can also be viewed as an expansion of the data in terms of the IMF's. Then, these IMF's, based on and derived from the data, can serve as the basis of that expansion. The local energy and the instantaneous frequency derived from the IMF's through the Hilbert transform give a full energy-frequency-time distribution of the data which is designated as the Hilbert Spectrum. The third step filters the physical signal by combining a subset of the IMFs. In the fourth step, a curve may be fitted to the filtered signal which may not have been possible with the original, unfiltered signal.

Empirical mode decomposition apparatus, method and article of manufacture for analyzing biological signals and performing curve fitting

NASA Technical Reports Server (NTRS)

Huang, Norden E. (Inventor)

2002-01-01

A computer implemented physical signal analysis method includes four basic steps and the associated presentation techniques of the results. The first step is a computer implemented Empirical Mode Decomposition that extracts a collection of Intrinsic Mode Functions (IMF) from nonlinear, nonstationary physical signals. The decomposition is based on the direct extraction of the energy associated with various intrinsic time scales in the physical signal. Expressed in the IMF's, they have well-behaved Hilbert Transforms from which instantaneous frequencies can be calculated. The second step is the Hilbert Transform which produces a Hilbert Spectrum. Thus, the invention can localize any event on the time as well as the frequency axis. The decomposition can also be viewed as an expansion of the data in terms of the IMF's. Then, these IMF's, based on and derived from the data, can serve as the basis of that expansion. The local energy and the instantaneous frequency derived from the IMF's through the Hilbert transform give a full energy-frequency-time distribution of the data which is designated as the Hilbert Spectrum. The third step filters the physical signal by combining a subset of the IMFs. In the fourth step, a curve may be fitted to the filtered signal which may not have been possible with the original, unfiltered signal.

Species composition and natural infectivity of anthropophilic Anopheles (Diptera: Culicidae) in Córdoba and Antioquia states in northwestern Colombia

PubMed Central

Gutiérrez, Lina A; González, John J; Gómez, Giovan F; Castro, Martha I; Rosero, Doris A; Luckhart, Shirley; Conn, Jan E; Correa, Margarita M

2011-01-01

Malaria is a serious health problem in Córdoba and Antioquia states in northwestern Colombia, where 64.4% of the total Colombian cases were reported in 2007. Because little entomological information is available in this region, the aim of this work was to identify the Anopheles species composition and natural infectivity of mosquitoes distributed in seven localities with the highest malaria transmission. A total of 1,768 Anopheles mosquitoes were collected using human landing catches from March 2007 to July 2008. Ten species were identified; overall, An. nuneztovari s.l. was the most widespread (62%) and showed the highest average human biting rates. There were six other species of the Nyssorhynchus subgenus: An. albimanus (11.6%), An. darlingi (9.8%), An. braziliensis (6.6%), An. triannulatus s.l. (3.5%), An. albitarsis s.l. and An. oswaldoi s.l. at <1%; and three of the Anopheles subgenus: An. punctimacula, An. pseudopunctipennis s.l. and An. neomaculipalpus at <1% each. Two species from Córdoba, An. nuneztovari and An. darlingi, were detected naturally infected by Plasmodium vivax VK247 using ELISA and confirmed by nested PCR. All species were active indoors and outdoors. These results provide basic information for targeted vector control strategies in these localities. PMID:20140372

Supporting 64-bit global indices in Epetra and other Trilinos packages :

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jhurani, Chetan; Austin, Travis M.; Heroux, Michael Allen

The Trilinos Project is an effort to facilitate the design, development, integration and ongoing support of mathematical software libraries within an object-oriented framework. It is intended for large-scale, complex multiphysics engineering and scientific applications [2, 4, 3]. Epetra is one of its basic packages. It provides serial and parallel linear algebra capabilities. Before Trilinos version 11.0, released in 2012, Epetra used the C++ int data-type for storing global and local indices for degrees of freedom (DOFs). Since int is typically 32-bit, this limited the largest problem size to be smaller than approximately two billion DOFs. This was true even ifmore » a distributed memory machine could handle larger problems. We have added optional support for C++ long long data-type, which is at least 64-bit wide, for global indices. To save memory, maintain the speed of memory-bound operations, and reduce further changes to the code, the local indices are still 32-bit. We document the changes required to achieve this feature and how the new functionality can be used. We also report on the lessons learned in modifying a mature and popular package from various perspectives design goals, backward compatibility, engineering decisions, C++ language features, effects on existing users and other packages, and build integration.« less

Numerical Study of g-Jitter Induced Double-Diffusive Convection

NASA Technical Reports Server (NTRS)

Shu, Y.; Li, B. Q.; deGroh, Henry C.

2001-01-01

A finite element study is presented of double-diffusive convection driven by g-jitter in a microgravity environment. Mathematical formulations are presented and extensive simulations are carried out for g-jitter induced fluid flow, temperature distribution, and solutal transport in an alloy system under consideration for space flights. Computations include the use of idealized single-frequency and multi-frequency g-jitter as well as the real g-jitter data taken during an actual Space Shuttle fight. Little correlation is seen between these velocity components for the g-jitter components studied. The temperature field is basically undisturbed by convection because of a small Pr number for the fluid. The disturbance of the concentration field, however, is pronounced, and the local variation of the concentration follows the velocity oscillation in time. It is found that although the concentration field varies in both position and time, the local concentration gradient remains approximately constant in time. Numerical study further indicates that with an increase in g-jitter force (or amplitude), the nonlinear convective effects become much more obvious, which in turn drastically change the concentration fields. The simulated results computed using the g-jitter data taken during space flights show that both the velocity and concentration become random, following approximately the same pattern as the g-jitter perturbations.

Effect of addition of GGBS and lime in soil stabilisation for stabilising local village roads in Thanjavur region

NASA Astrophysics Data System (ADS)

Saravanan, R.; Udhayakumar, T.; Dinesh, S.; Venkatasubramanian, C.; Muthu, D.

2017-07-01

Construction of pavements uses various filling materials and due to the cost factor, the local soil is used for pavement construction. The strength of the soil is improved by stabilisation. This stabilisation increases the load bearing capacities of soil for heavy wheeled vehicle traffic. GGBS, silica fume, rice husk are the basic waste materials used as a waste material, which improves the quality of soil and reduces the cost of pavements. In this study, a detailed investigation is made on the Ground Granulated Blast-furnace Slag (GGBS), activated by lime, in the stabilisation of low bearing capacity sand and clay soils collected from Thanjavur district (Budalur, Sengipatti, Vallam and Palliahgraharam villages). The tests are carried out as per Indian Standards. The test procedures separated into two phases, namely Stage-I and Stage-II. In Stage-I the soil tests include soil type, particle size distribution, soil index properties, standard proctor tests, shear tests and CBR test. In Stage-II the soil tests include shear tests and CBR test for the suitable required proportions of GGBS along with lime in the collected soil samples. The test results from stage-I and stage-II are compared and from the study, it is inferred that the application of GGBS is a useful material for soil stabilisation.

A Robust Function to Return the Cumulative Density of Non-Central F Distributions in Microsoft Office Excel

ERIC Educational Resources Information Center

Nelson, James Byron

2016-01-01

The manuscript presents a Visual Basic[superscript R] for Applications function that operates within Microsoft Office Excel[superscript R] to return the area below the curve for a given F within a specified non-central F distribution. The function will be of use to Excel users without programming experience wherever a non-central F distribution is…

Current state of the art for statistical modeling of species distributions [Chapter 16

Treesearch

Troy M. Hegel; Samuel A. Cushman; Jeffrey Evans; Falk Huettmann

2010-01-01

Over the past decade the number of statistical modelling tools available to ecologists to model species' distributions has increased at a rapid pace (e.g. Elith et al. 2006; Austin 2007), as have the number of species distribution models (SDM) published in the literature (e.g. Scott et al. 2002). Ten years ago, basic logistic regression (Hosmer and Lemeshow 2000)...

Community Seismic Network

NASA Astrophysics Data System (ADS)

Clayton, R. W.; Kohler, M. D.; Massari, A.; Heaton, T. H.; Guy, R.; Chandy, M.; Bunn, J.; Strand, L.

2014-12-01

The CSN is now in its 3rdyear of operation and has expanded to 400 stations in the Los Angeles region. The goal of the network is to produce a map of strong shaking immediately following a major earthquake as a proxy for damage and a guide for first responders. We have also instrumented a number of buildings with the goal of determining the state of health of these structures before and after they have been shaken. In one 15-story structure, our sensors distributed two per floor, and show body waves propagating in the structure after a moderate local earthquake (M4.4 in Encino, CA). Sensors in a 52-story structure, which we plan to instrument with two sensors per floor as well, show the modes of the building (see Figure) down to the fundamental mode at 5 sec due to a M5.1 earthquake in La Habra, CA. The CSN utilizes a number of technologies that will likely be important in building robust low-cost networks. These include: Distributed computing - the sensors themselves are smart-sensors that perform the basic detection and size estimation in the onboard computers and send the results immediately (without packetization latency) to the central facility. Cloud computing - the central facility is housed in the cloud, which means it is more robust than a local site, and has expandable computing resources available so that it can operate with minimal resources during quiet times but still be able to exploit an very large computing facility during an earthquake. Low-cost/low-maintenance sensors - the MEM sensors are capable of staying onscale to +/- 2g, and can measure events in the Los Angeles Basin a low as magnitude 3.

Supporting tobacco control: stimulating local newspaper coverage with a technical assistance website for local coalitions.

PubMed

Buller, David B; Bettinghaus, Erwin P; Helme, Donald; Young, Walter F; Borland, Ron; Maloy, Julie A; Cutter, Gary R; Andersen, Peter A; Walther, Joseph B

2011-11-01

A large and growing literature confirms that well-designed web-based programs can be effective in preventing or treating several chronic diseases. This study examined how the Internet can deliver information and train community activists and specifically tested the effects of web-based technical assistance on local tobacco control coalitions' efforts to use media advocacy to advance their agendas. The authors compared a highly interactive, Enhanced website (intervention) to a noninteractive, Basic text-based website (comparison) in Colorado communities. A total of 24 tobacco control coalitions led by local county health departments and nursing services were enrolled in the project and randomly assigned to use either the intervention or comparison website. A total of 73 local daily and weekly newspapers were identified in the service areas of 23 of the 24 coalitions. A posttest assessment of newspaper coverage was conducted to locate all newspaper articles with tobacco control information published between January 1 and April 9, 2004, the last 3 months of the intervention. Although there was no evidence of a treatment effect on the frequency of newspaper articles on tobacco-related issues, there was, however, evidence that newspapers in counties where the coalition had access to the Enhanced website printed more stories focused on local/regional issues and more anti-tobacco local/regional stories than in the counties where coalitions had access to the Basic website. Coalitions can improve their influence on local media for community tobacco control when high-quality online technical assistance, training, and resources are available to them.

Advanced Beamforming Concepts: Source Localization Using the Bispectrum, Gabor Transform, Wigner-Ville Distribution, and Nonstationary Signal Representation

DTIC Science & Technology

1991-12-01

TRANSFORM, WIGNER - VILLE DISTRIBUTION , AND NONSTATIONARY SIGNAL REPRESENTATIONS 6. AUTHOR(S) J. C. Allen 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS...bispectrum yields a bispectral direction finder. Estimates of time-frequency distributions produce Wigner - Ville and Gabor direction-finders. Some types...Beamforming Concepts: Source Localization Using the Bispectrum, Gabor Transform, Wigner - Ville Distribution , and Nonstationary Signal Representations

Determine Neuronal Tuning Curves by Exploring Optimum Firing Rate Distribution for Information Efficiency

PubMed Central

Han, Fang; Wang, Zhijie; Fan, Hong

2017-01-01

This paper proposed a new method to determine the neuronal tuning curves for maximum information efficiency by computing the optimum firing rate distribution. Firstly, we proposed a general definition for the information efficiency, which is relevant to mutual information and neuronal energy consumption. The energy consumption is composed of two parts: neuronal basic energy consumption and neuronal spike emission energy consumption. A parameter to model the relative importance of energy consumption is introduced in the definition of the information efficiency. Then, we designed a combination of exponential functions to describe the optimum firing rate distribution based on the analysis of the dependency of the mutual information and the energy consumption on the shape of the functions of the firing rate distributions. Furthermore, we developed a rapid algorithm to search the parameter values of the optimum firing rate distribution function. Finally, we found with the rapid algorithm that a combination of two different exponential functions with two free parameters can describe the optimum firing rate distribution accurately. We also found that if the energy consumption is relatively unimportant (important) compared to the mutual information or the neuronal basic energy consumption is relatively large (small), the curve of the optimum firing rate distribution will be relatively flat (steep), and the corresponding optimum tuning curve exhibits a form of sigmoid if the stimuli distribution is normal. PMID:28270760

Basic visual function and cortical thickness patterns in posterior cortical atrophy.

PubMed

Lehmann, Manja; Barnes, Josephine; Ridgway, Gerard R; Wattam-Bell, John; Warrington, Elizabeth K; Fox, Nick C; Crutch, Sebastian J

2011-09-01

Posterior cortical atrophy (PCA) is characterized by a progressive decline in higher-visual object and space processing, but the extent to which these deficits are underpinned by basic visual impairments is unknown. This study aimed to assess basic and higher-order visual deficits in 21 PCA patients. Basic visual skills including form detection and discrimination, color discrimination, motion coherence, and point localization were measured, and associations and dissociations between specific basic visual functions and measures of higher-order object and space perception were identified. All participants showed impairment in at least one aspect of basic visual processing. However, a number of dissociations between basic visual skills indicated a heterogeneous pattern of visual impairment among the PCA patients. Furthermore, basic visual impairments were associated with particular higher-order object and space perception deficits, but not with nonvisual parietal tasks, suggesting the specific involvement of visual networks in PCA. Cortical thickness analysis revealed trends toward lower cortical thickness in occipitotemporal (ventral) and occipitoparietal (dorsal) regions in patients with visuoperceptual and visuospatial deficits, respectively. However, there was also a lot of overlap in their patterns of cortical thinning. These findings suggest that different presentations of PCA represent points in a continuum of phenotypical variation.

Quantifying and Mapping the Supply of and Demand for Carbon Storage and Sequestration Service from Urban Trees.

PubMed

Zhao, Chang; Sander, Heather A

2015-01-01

Studies that assess the distribution of benefits provided by ecosystem services across urban areas are increasingly common. Nevertheless, current knowledge of both the supply and demand sides of ecosystem services remains limited, leaving a gap in our understanding of balance between ecosystem service supply and demand that restricts our ability to assess and manage these services. The present study seeks to fill this gap by developing and applying an integrated approach to quantifying the supply and demand of a key ecosystem service, carbon storage and sequestration, at the local level. This approach follows three basic steps: (1) quantifying and mapping service supply based upon Light Detection and Ranging (LiDAR) processing and allometric models, (2) quantifying and mapping demand for carbon sequestration using an indicator based on local anthropogenic CO2 emissions, and (3) mapping a supply-to-demand ratio. We illustrate this approach using a portion of the Twin Cities Metropolitan Area of Minnesota, USA. Our results indicate that 1735.69 million kg carbon are stored by urban trees in our study area. Annually, 33.43 million kg carbon are sequestered by trees, whereas 3087.60 million kg carbon are emitted by human sources. Thus, carbon sequestration service provided by urban trees in the study location play a minor role in combating climate change, offsetting approximately 1% of local anthropogenic carbon emissions per year, although avoided emissions via storage in trees are substantial. Our supply-to-demand ratio map provides insight into the balance between carbon sequestration supply in urban trees and demand for such sequestration at the local level, pinpointing critical locations where higher levels of supply and demand exist. Such a ratio map could help planners and policy makers to assess and manage the supply of and demand for carbon sequestration.

Conserving mangrove ecosystems in the Philippines: transcending disciplinary and institutional borders.

PubMed

Farley, Joshua; Batker, David; de la Torre, Isabel; Hudspeth, Tom

2010-01-01

Humans are rapidly depleting critical ecosystems and the life support functions they provide, increasing the urgency of developing effective conservation tools. Using a case study of the conversion of mangrove ecosystems to shrimp aquaculture, this article describes an effort to develop a transdisciplinary, transinstitutional approach to conservation that simultaneously trains future generations of environmental problem solvers. We worked in close collaboration with academics, non-government organizations, local government and local communities to organize a workshop in Puerto Princesa, Palawan, Philippines. The primary objectives of the workshop were to: (1) train participants in the basic principles of ecological economics and its goals of sustainable scale, just distribution and efficient allocation; (2) learn from local community stakeholders and participating scientists about the problems surrounding conversion of mangrove ecosystems to shrimp aquaculture; (3) draw on the skills and knowledge of all participants to develop potential solutions to the problem; and (4) communicate results to those with the power and authority to act on them. We found that the economic and ecological benefits of intact mangroves outweigh the returns to aquaculture. Perversely, however, private property rights to mangrove ecosystems favor inefficient, unjust and unsustainable allocation of the resource-a tragedy of the non-commons. We presented the workshop results to the press and local government, which shut down the aquaculture ponds to conserve the threatened ecosystem. Effective communication to appropriate audiences was essential for transforming research into action. Our approach is promising and can be readily applied to conservation research and advocacy projects worldwide, but should be improved through adaptive management-practitioners must continually build on those elements that work and discard or improve those that fail.

Mechanical response of collagen molecule under hydrostatic compression.

PubMed

Saini, Karanvir; Kumar, Navin

2015-04-01

Proteins like collagen are the basic building blocks of various body tissues (soft and hard). Collagen molecules find their presence in the skeletal system of the body where they bear mechanical loads from different directions, either individually or along with hydroxy-apatite crystals. Therefore, it is very important to understand the mechanical behavior of the collagen molecule which is subjected to multi-axial state of loading. The estimation of strains of collagen molecule along different directions resulting from the changes in hydrostatic pressure magnitude, can provide us new insights into its mechanical behavior. In the present work, full atomistic simulations have been used to study global (volumetric) as well as local (along different directions) mechanical properties of the hydrated collagen molecule which is subjected to different hydrostatic pressure magnitudes. To estimate the local mechanical properties, the strains of collagen molecule along its longitudinal and transverse directions have been acquired at different hydrostatic pressure magnitudes. In spite of non-homogeneous distribution of atoms within the collagen molecule, the calculated values of local mechanical properties have been found to carry the same order of magnitude along the longitudinal and transverse directions. It has been demonstrated that the values of global mechanical properties like compressibility, bulk modulus, etc. as well as local mechanical properties like linear compressibility, linear elastic modulus, etc. are functions of magnitudes of applied hydrostatic pressures. The mechanical characteristics of collagen molecule based on the atomistic model have also been compared with that of the continuum model in the present work. The comparison showed up orthotropic material behavior for the collagen molecule. The information on collagen molecule provided in the present study can be very helpful in designing the future bio-materials. Copyright © 2015 Elsevier B.V. All rights reserved.

Southern African continental climate since the late Pleistocene: Insights from biomarker analyses of Kalahari salt pan sediments

NASA Astrophysics Data System (ADS)

Belz, Lukas; Schüller, Irka; Wehrmann, Achim; Wilkes, Heinz

2016-04-01

The climate system of sub-tropical southern Africa is mainly controlled by large scale atmospheric and marine circulation processes and, therefore, very sensitive to global climate change. This underlines the importance of paleoenvironmental reconstructions in order to estimate regional implications of current global changes. However, the majority of studies on southern African paleoclimate are based on the investigation of marine sedimentary archives and past climate development especially in continental areas is still poorly understood. This emphasizes the necessity of continental proxy-data from this area. Proxy datasets from local geoarchives especially of the southwestern Kalahari region are still scarce. A main problem is the absence of conventional continental climatic archives, due to the lack of lacustrine systems. In this study we are exploring the utility of sediments from western Kalahari salt pans, i.e. local depressions which are flooded temporarily during rainfall events. An age model based on 14C dating of total organic carbon (TOC) shows evidence that sedimentation predominates over erosional processes with respect to pan formation. Besides the analyses of basic geochemical bulk parameters including TOC, δ13CTOC, total inorganic carbon, δ13CTIC, δ18OTIC, total nitrogen and δ15N, our paleo-climatic approach focuses on reconstruction of local vegetation assemblages to identify changes in the ecosystem. This is pursued using plant biomarkers, particularly leaf wax n-alkanes and n-alcohols and their stable carbon and hydrogen isotopic signatures. Results show prominent shifts in n-alkane and n-alkanol distributions and compound specific carbon isotope values, pointing to changes to a more grass dominated environment during Heinrich Stadial 1 (18.5-14.6 ka BP), while hydrogen isotope values suggest wetter phases during Holocene and LGM. This high variability indicates the local vulnerability to global change.

Conserving Mangrove Ecosystems in the Philippines: Transcending Disciplinary and Institutional Borders

NASA Astrophysics Data System (ADS)

Farley, Joshua; Batker, David; de La Torre, Isabel; Hudspeth, Tom

2010-01-01

Humans are rapidly depleting critical ecosystems and the life support functions they provide, increasing the urgency of developing effective conservation tools. Using a case study of the conversion of mangrove ecosystems to shrimp aquaculture, this article describes an effort to develop a transdisciplinary, transinstitutional approach to conservation that simultaneously trains future generations of environmental problem solvers. We worked in close collaboration with academics, non-government organizations, local government and local communities to organize a workshop in Puerto Princesa, Palawan, Philippines. The primary objectives of the workshop were to: (1) train participants in the basic principles of ecological economics and its goals of sustainable scale, just distribution and efficient allocation; (2) learn from local community stakeholders and participating scientists about the problems surrounding conversion of mangrove ecosystems to shrimp aquaculture; (3) draw on the skills and knowledge of all participants to develop potential solutions to the problem; and (4) communicate results to those with the power and authority to act on them. We found that the economic and ecological benefits of intact mangroves outweigh the returns to aquaculture. Perversely, however, private property rights to mangrove ecosystems favor inefficient, unjust and unsustainable allocation of the resource—a tragedy of the non-commons. We presented the workshop results to the press and local government, which shut down the aquaculture ponds to conserve the threatened ecosystem. Effective communication to appropriate audiences was essential for transforming research into action. Our approach is promising and can be readily applied to conservation research and advocacy projects worldwide, but should be improved through adaptive management—practitioners must continually build on those elements that work and discard or improve those that fail.

Local Chemical Ordering and Negative Thermal Expansion in PtNi Alloy Nanoparticles.

PubMed

Li, Qiang; Zhu, He; Zheng, Lirong; Fan, Longlong; Wang, Na; Rong, Yangchun; Ren, Yang; Chen, Jun; Deng, Jinxia; Xing, Xianran

2017-12-13

An atomic insight into the local chemical ordering and lattice strain is particular interesting to recent emerging bimetallic nanocatalysts such as PtNi alloys. Here, we reported the atomic distribution, chemical environment, and lattice thermal evolution in full-scale structural description of PtNi alloy nanoparticles (NPs). The different segregation of elements in the well-faceted PtNi nanoparticles is convinced by extended X-ray absorption fine structure (EXAFS). Atomic pair distribution function (PDF) study evidences the coexistence of the face-centered cubic and tetragonal ordering parts in the local environment of PtNi nanoparticles. Further reverse Monte Carlo (RMC) simulation with PDF data obviously exposed the segregation as Ni and Pt in the centers of {111} and {001} facets, respectively. Layer-by-layer statistical analysis up to 6 nm for the local atomic pairs revealed the distribution of local tetragonal ordering on the surface. This local coordination environment facilitates the distribution of heteroatomic Pt-Ni pairs, which plays an important role in the negative thermal expansion of Pt 41 Ni 59 NPs. The present study on PtNi alloy NPs from local short-range coordination to long-range average lattice provides a new perspective on tailoring physical properties in nanomaterials.

34 CFR 200.45 - Supplemental educational services.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Improving Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.45 Supplemental educational services. (a) Definition. “Supplemental educational services” means tutoring and other...

Basic Information About the School Siting Guidelines

EPA Pesticide Factsheets

EPA's voluntary school siting guidelines provide recommendations for local school districts and community members on how to evaluate environmental factors to make the best possible school siting decisions.

MADE 2. Marketing and Distributive Education Competency Based Curriculum Guide.

ERIC Educational Resources Information Center

New Jersey State Dept. of Education, Trenton. Div. of Vocational Education.

This curriculum guide is one in a series of three competency-based instructional materials dealing with marketing and distributive education (MADE). Covered in the individual sections of the guide are the following topics: job orientation (personal appearance, job opportunities, job interviews, basic skills, training plans, legal requirements, and…

A Framework for a Computer System to Support Distributed Cooperative Learning

ERIC Educational Resources Information Center

Chiu, Chiung-Hui

2004-01-01

To develop a computer system to support cooperative learning among distributed students; developers should consider the foundations of cooperative learning. This article examines the basic elements that make cooperation work and proposes a framework for such computer supported cooperative learning (CSCL) systems. This framework is constituted of…

Distance-Based and Distributed Learning: A Decision Tool for Education Leaders.

ERIC Educational Resources Information Center

McGraw, Tammy M.; Ross, John D.

This decision tool presents a progression of data collection and decision-making strategies that can increase the effectiveness of distance-based or distributed learning instruction. A narrative and flow chart cover the following steps: (1) basic assumptions, including purpose of instruction, market scan, and financial resources; (2) needs…

34 CFR 403.119 - Under what circumstances may the State waive the distribution requirements for Secondary School...

Code of Federal Regulations, 2010 CFR

2010-07-01

... the Basic Programs? Secondary, Postsecondary, and Adult Vocational Education Programs § 403.119 Under... distribution requirements for Secondary School Vocational Education Program or the Postsecondary and Adult... of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

34 CFR 403.119 - Under what circumstances may the State waive the distribution requirements for Secondary School...

Code of Federal Regulations, 2013 CFR

2013-07-01

... the Basic Programs? Secondary, Postsecondary, and Adult Vocational Education Programs § 403.119 Under... distribution requirements for Secondary School Vocational Education Program or the Postsecondary and Adult... of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

34 CFR 403.119 - Under what circumstances may the State waive the distribution requirements for Secondary School...

Code of Federal Regulations, 2014 CFR

2014-07-01

... the Basic Programs? Secondary, Postsecondary, and Adult Vocational Education Programs § 403.119 Under... distribution requirements for Secondary School Vocational Education Program or the Postsecondary and Adult... of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

34 CFR 403.119 - Under what circumstances may the State waive the distribution requirements for Secondary School...

Code of Federal Regulations, 2011 CFR

2011-07-01

... the Basic Programs? Secondary, Postsecondary, and Adult Vocational Education Programs § 403.119 Under... distribution requirements for Secondary School Vocational Education Program or the Postsecondary and Adult... of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

34 CFR 403.119 - Under what circumstances may the State waive the distribution requirements for Secondary School...

Code of Federal Regulations, 2012 CFR

2012-07-01

... the Basic Programs? Secondary, Postsecondary, and Adult Vocational Education Programs § 403.119 Under... distribution requirements for Secondary School Vocational Education Program or the Postsecondary and Adult... of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

Dose distribution of a 125 keV mean energy microplanar x-ray beam for basic studies on microbeam radiotherapy.

PubMed

Ohno, Yumiko; Torikoshi, Masami; Suzuki, Masao; Umetani, Keiji; Imai, Yasuhiko; Uesugi, Kentaro; Yagi, Naoto

2008-07-01

A multislit collimator was designed and fabricated for basic studies on microbeam radiation therapy (MRT) with an x-ray energy of about 100 keV. It consists of 30 slits that are 25 microm high, 30 mm wide, and 5 mm thick in the beam direction. The slits were made of 25 microm-thick polyimide sheets that were separated by 175 microm-thick tungsten sheets. The authors measured the dose distribution of a single microbeam with a mean energy of 125 keV by a scanning slit method using a phosphor coupled to a charge coupled device camera and found that the ratios of the dose at the center of a microbeam to that at midpositions to adjacent slits were 1050 and 760 for each side of the microbeam. This dose distribution was well reproduced by the Monte Carlo simulation code PHITS.

Benefit distribution of social health insurance: evidence from china's urban resident basic medical insurance.

PubMed

Pan, Jay; Tian, Sen; Zhou, Qin; Han, Wei

2016-09-01

Equity is one of the essential objectives of the social health insurance. This article evaluates the benefit distribution of the China's Urban Residents' Basic Medical Insurance (URBMI), covering 300 million urban populations. Using the URBMI Household Survey data fielded between 2007 and 2011, we estimate the benefit distribution by the two-part model, and find that the URBMI beneficiaries from lower income groups benefited less than that of higher income groups. In other words, government subsidy that was supposed to promote the universal coverage of health care flew more to the rich. Our study provides new evidence on China's health insurance system reform, and it bears meaningful policy implication for other developing countries facing similar challenges on the way to universal coverage of health insurance. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Source Distribution Method for Unsteady One-Dimensional Flows With Small Mass, Momentum, and Heat Addition and Small Area Variation

NASA Technical Reports Server (NTRS)

Mirels, Harold

1959-01-01

A source distribution method is presented for obtaining flow perturbations due to small unsteady area variations, mass, momentum, and heat additions in a basic uniform (or piecewise uniform) one-dimensional flow. First, the perturbations due to an elemental area variation, mass, momentum, and heat addition are found. The general solution is then represented by a spatial and temporal distribution of these elemental (source) solutions. Emphasis is placed on discussing the physical nature of the flow phenomena. The method is illustrated by several examples. These include the determination of perturbations in basic flows consisting of (1) a shock propagating through a nonuniform tube, (2) a constant-velocity piston driving a shock, (3) ideal shock-tube flows, and (4) deflagrations initiated at a closed end. The method is particularly applicable for finding the perturbations due to relatively thin wall boundary layers.

Entanglement Properties and Quantum Phases for a Fermionic Disordered One-Dimensional Wire with Attractive Interactions.

PubMed

Berkovits, Richard

2015-11-13

A fermionic disordered one-dimensional wire in the presence of attractive interactions is known to have two distinct phases, a localized and superconducting, depending on the strength of interaction and disorder. The localized region may also exhibit a metallic behavior if the system size is shorter than the localization length. Here we show that the superconducting phase has a distribution of the entanglement entropy distinct from the metallic regime. The entanglement entropy distribution is strongly asymmetric with a Lévy α-stable distribution (compared to the Gaussian metallic distribution), as is seen also for the second Rényi entropy distribution. Thus, entanglement properties may reveal properties which cannot be detected by other methods.

Performance of distributed multiscale simulations

PubMed Central

Borgdorff, J.; Ben Belgacem, M.; Bona-Casas, C.; Fazendeiro, L.; Groen, D.; Hoenen, O.; Mizeranschi, A.; Suter, J. L.; Coster, D.; Coveney, P. V.; Dubitzky, W.; Hoekstra, A. G.; Strand, P.; Chopard, B.

2014-01-01

Multiscale simulations model phenomena across natural scales using monolithic or component-based code, running on local or distributed resources. In this work, we investigate the performance of distributed multiscale computing of component-based models, guided by six multiscale applications with different characteristics and from several disciplines. Three modes of distributed multiscale computing are identified: supplementing local dependencies with large-scale resources, load distribution over multiple resources, and load balancing of small- and large-scale resources. We find that the first mode has the apparent benefit of increasing simulation speed, and the second mode can increase simulation speed if local resources are limited. Depending on resource reservation and model coupling topology, the third mode may result in a reduction of resource consumption. PMID:24982258

Audio gunshot detection and localization systems: History, basic design, and future possibilities

NASA Astrophysics Data System (ADS)

Graves, Jordan R.

For decades, law enforcement organizations have increasingly utilized audio detection and localization systems to identify potential gunshot incidents and to respond accordingly. These systems have grown from simple microphone configurations used to estimate location into complex arrays that seem to pinpoint gunfire to within mere feet of its actual occurrence. Such technology comes from a long and dynamic history of developing equipment dating back to the First World War. Additionally, though basic designs require little in terms of programming or engineering experience, the mere presence of this tool invokes a firestorm of debate amongst economists, law enforcement groups, and the general public, which leads to questions about future possibilities for its use. The following pages will retell the history of these systems from theoretical conception to current capabilities. This work will also dissect these systems to reveal fundamental elements of their inner workings, in order to build a basic demonstrative system. Finally, this work will discuss some legal and moral points of dissension, and will explore these systems’ roles in society now and in the future, in additional applications as well.

Distribution of localized states from fine analysis of electron spin resonance spectra of organic semiconductors: Physical meaning and methodology

NASA Astrophysics Data System (ADS)

Mishchenko, Andrey S.; Matsui, Hiroyuki; Hasegawa, Tatsuo

2012-02-01

We develop an analytical method for the processing of electron spin resonance (ESR) spectra. The goal is to obtain the distributions of trapped carriers over both their degree of localization and their binding energy in semiconductor crystals or films composed of regularly aligned organic molecules [Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.104.056602 104, 056602 (2010)]. Our method has two steps. We first carry out a fine analysis of the shape of the ESR spectra due to the trapped carriers; this reveals the distribution of the trap density of the states over the degree of localization. This analysis is based on the reasonable assumption that the linewidth of the trapped carriers is predetermined by their degree of localization because of the hyperfine mechanism. We then transform the distribution over the degree of localization into a distribution over the binding energies. The transformation uses the relationships between the binding energies and the localization parameters of the trapped carriers. The particular relation for the system under study is obtained by the Holstein model for trapped polarons using a diagrammatic Monte Carlo analysis. We illustrate the application of the method to pentacene organic thin-film transistors.

Dependence of Capillary Properties of Contemporary Clinker Bricks on Their Microstructure

NASA Astrophysics Data System (ADS)

Wesołowska, Maria; Kaczmarek, Anna

2017-10-01

Contemporary clinker bricks are applied for outer layers of walls built from other materials and walls which should have high durability and aesthetic qualities. The intended effect depends not only on the mortar applied but also on clinker properties. Traditional macroscopic tests do not allow to predict clinker behaviour in contact with mortars and external environment. The basic information for this issue is open porosity of material. It defines the material ability to absorb liquids: rain water (through the face wall surface) and grout from mortar (through base surface). The main capillary flow goes on in pores with diameters from 300 to 3000nm. It is possible to define pore distribution and their size using the Mercury Intrusion Porosimetry method. The aim of these research is evaluation of clinker brick capillary properties (initial water absorption and capillary rate) and analysis of differences in microstructure of the face and base wall of a product. Detailed results allowed to show pore distribution in function of their diameters and definition of pore amount responsible for capillary flow. Based on relation between volume function differential and pore diameter, a differential distribution curve was obtained which helped to determine the dominant diameters. The results obtained let us state that face wall of bricks was characterized with the lowest material density and open porosity. In this layer (most burnt) part of pores could be closed by locally appearing liquid phase during brick burning. Thus density is lower comparing to other part of the product.

Biodiversity, molecular ecology and phylogeography of marine sponges: patterns, implications and outlooks.

PubMed

Wörheide, Gert; Solé-Cava, Antonio M; Hooper, John N A

2005-04-01

Marine sponges are an ecologically important and highly diverse component of marine benthic communities, found in all the world's oceans, at all depths. Although their commercial potential and evolutionary importance is increasingly recognized, many pivotal aspects of their basic biology remain enigmatic. Knowledge of historical biogeographic affinities and biodiversity patterns is rudimentary, and there are still few data about genetic variation among sponge populations and spatial patterns of this variation. Biodiversity analyses of tropical Australasian sponges revealed spatial trends not universally reflected in the distributions of other marine phyla within the Indo-West Pacific region. At smaller spatial scales sponges frequently form heterogeneous, spatially patchy assemblages, with some empirical evidence suggesting that environmental variables such as light and/or turbidity strongly contribute to local distributions. There are no apparent latitudinal diversity gradients at larger spatial scales but stochastic processes, such as changing current patterns, the presence or absence of major carbonate platforms and historical biogeography, may determine modern day distributions. Studies on Caribbean oceanic reefs have revealed similar patterns, only weakly correlated with environmental factors. However, several questions remain where molecular approaches promise great potential, e.g., concerning connectivity and biogeographic relationships. Studies to date have helped to reveal that sponge populations are genetically highly structured and that historical processes might play an important role in determining such structure. Increasingly sophisticated molecular tools are now being applied, with results contributing significantly to a better understanding of poriferan microevolutionary processes and molecular ecology.

Fisher's geometrical model emerges as a property of complex integrated phenotypic networks.

PubMed

Martin, Guillaume

2014-05-01

Models relating phenotype space to fitness (phenotype-fitness landscapes) have seen important developments recently. They can roughly be divided into mechanistic models (e.g., metabolic networks) and more heuristic models like Fisher's geometrical model. Each has its own drawbacks, but both yield testable predictions on how the context (genomic background or environment) affects the distribution of mutation effects on fitness and thus adaptation. Both have received some empirical validation. This article aims at bridging the gap between these approaches. A derivation of the Fisher model "from first principles" is proposed, where the basic assumptions emerge from a more general model, inspired by mechanistic networks. I start from a general phenotypic network relating unspecified phenotypic traits and fitness. A limited set of qualitative assumptions is then imposed, mostly corresponding to known features of phenotypic networks: a large set of traits is pleiotropically affected by mutations and determines a much smaller set of traits under optimizing selection. Otherwise, the model remains fairly general regarding the phenotypic processes involved or the distribution of mutation effects affecting the network. A statistical treatment and a local approximation close to a fitness optimum yield a landscape that is effectively the isotropic Fisher model or its extension with a single dominant phenotypic direction. The fit of the resulting alternative distributions is illustrated in an empirical data set. These results bear implications on the validity of Fisher's model's assumptions and on which features of mutation fitness effects may vary (or not) across genomic or environmental contexts.

Towards a Predictive Theory of Malaria: Connections to Spatio-temporal Variability of Climate and Hydrology

NASA Astrophysics Data System (ADS)

Endo, N.; Eltahir, E. A. B.

2015-12-01

Malaria transmission is closely linked to climatology, hydrology, environment, and the biology of local vectors. These factors interact with each other and non-linearly influence malaria transmission dynamics, making prediction and prevention challenging. Our work attempts to find a universality in the multi-dimensional system of malaria transmission and to develop a theory to predict emergence of malaria given a limited set of environmental and biological inputs.A credible malaria transmission dynamics model, HYDREMATS (Bomblies et al., 2008), was used under hypothetical settings to investigate the role of spatial and temporal distribution of vector breeding pools. HYDREMATS is a mechanistic model and capable of simulating the basic reproduction rate (Ro) without bold assumptions even under dynamic conditions. The spatial distribution of pools is mainly governed by hydrological factors; the impact of pool persistence and rainy season length on malaria transmission were investigated. Also analyzed was the impact of the temporal distribution of pools relative to human houses. We developed non-dimensional variables combining the hydrological and biological parameters. Simulated values of Ro from HYDREMATS are presented in a newly-introduced non-dimensional plane, which leads to a some-what universal theory describing the condition for sustainable malaria transmission. The findings were tested against observations both from the West Africa and the Ethiopian Highland, representing diverse hydroclimatological conditions. Predicated Ro values from the theory over the two regions are in good agreement with the observed malaria transmission data.

Vba2p, a vacuolar membrane protein involved in basic amino acid transport in Schizosaccharomyces pombe.

PubMed

Sugimoto, Naoko; Iwaki, Tomoko; Chardwiriyapreecha, Soracom; Shimazu, Masamitsu; Sekito, Takayuki; Takegawa, Kaoru; Kakinuma, Yoshimi

2010-01-01

A recent study filling the gap in the genome sequence in the left arm of chromosome 2 of Schizosaccharomyces pombe revealed a homolog of budding yeast Vba2p, a vacuolar transporter of basic amino acids. GFP-tagged Vba2p in fission yeast was localized to the vacuolar membrane. Upon disruption of vba2, the uptake of several amino acids, including lysine, histidine, and arginine, was impaired. A transient increase in lysine uptake under nitrogen starvation was lowered by this mutation. These findings suggest that Vba2p is involved in basic amino acid transport in S. pombe under diverse conditions.

Discrete disorder models for many-body localization

NASA Astrophysics Data System (ADS)

Janarek, Jakub; Delande, Dominique; Zakrzewski, Jakub

2018-04-01

Using exact diagonalization technique, we investigate the many-body localization phenomenon in the 1D Heisenberg chain comparing several disorder models. In particular we consider a family of discrete distributions of disorder strengths and compare the results with the standard uniform distribution. Both statistical properties of energy levels and the long time nonergodic behavior are discussed. The results for different discrete distributions are essentially identical to those obtained for the continuous distribution, provided the disorder strength is rescaled by the standard deviation of the random distribution. Only for the binary distribution significant deviations are observed.

25 CFR 36.111 - Can a tribe, tribal governing body, or local school board waive the homeliving standards?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Can a tribe, tribal governing body, or local school board waive the homeliving standards? 36.111 Section 36.111 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION MINIMUM ACADEMIC STANDARDS FOR THE BASIC EDUCATION OF INDIAN CHILDREN AND...

Property Accounting for Local and State School Systems. State Educational Records and Reports Series--Handbook III.

ERIC Educational Resources Information Center

Reason, Paul L.; Tankard, George G., Jr.

This handbook serves as a basic guide to property accounting for local and state school systems in the U.S. Information and guidelines are presented regarding--(1) classification of property accounts, (2) definitions of property accounts, (3) measures of school property, (4) supplies and equipment, (5) individual property records, and (6) summary…

45 CFR 2522.910 - What basic qualifications must an AmeriCorps member have to serve as a tutor?

Code of Federal Regulations, 2014 CFR

2014-10-01

... (b) Is not considered to be an employee of the Local Education Agency or school, as determined by State law (1) High School diploma or its equivalent, or a higher degree; and (2) Successful completion... qualifications: (a) Is considered to be an employee of the Local Education Agency or school, as determined by...

45 CFR 2522.910 - What basic qualifications must an AmeriCorps member have to serve as a tutor?

Code of Federal Regulations, 2012 CFR

2012-10-01

... (b) Is not considered to be an employee of the Local Education Agency or school, as determined by State law (1) High School diploma or its equivalent, or a higher degree; and (2) Successful completion... qualifications: (a) Is considered to be an employee of the Local Education Agency or school, as determined by...

45 CFR 2522.910 - What basic qualifications must an AmeriCorps member have to serve as a tutor?

Code of Federal Regulations, 2011 CFR

2011-10-01

... (b) Is not considered to be an employee of the Local Education Agency or school, as determined by State law (1) High School diploma or its equivalent, or a higher degree; and (2) Successful completion... qualifications: (a) Is considered to be an employee of the Local Education Agency or school, as determined by...

45 CFR 2522.910 - What basic qualifications must an AmeriCorps member have to serve as a tutor?

Code of Federal Regulations, 2013 CFR

2013-10-01

... (b) Is not considered to be an employee of the Local Education Agency or school, as determined by State law (1) High School diploma or its equivalent, or a higher degree; and (2) Successful completion... qualifications: (a) Is considered to be an employee of the Local Education Agency or school, as determined by...

Putting the Pieces Together: Toward a Comprehensive Program of Social Reform (Reformulating Our Approaches to School Governance).

ERIC Educational Resources Information Center

Cunningham, Luvern L.

1991-01-01

Basic tenets of citizen control of education at state and local levels are well established historically and remain intact after three centuries of U.S. educational experience. This paper advocates substantial change in the structure and management of local governments. Too many change proposals are cosmetic. Kentucky and Memphis-Shelby County are…