Science.gov

Sample records for distribution primary circuits

  1. Spatiotemporal dynamics of distributed synthetic genetic circuits

    NASA Astrophysics Data System (ADS)

    Kanakov, Oleg; Laptyeva, Tetyana; Tsimring, Lev; Ivanchenko, Mikhail

    2016-04-01

    We propose and study models of two distributed synthetic gene circuits, toggle-switch and oscillator, each split between two cell strains and coupled via quorum-sensing signals. The distributed toggle switch relies on mutual repression of the two strains, and oscillator is comprised of two strains, one of which acts as an activator for another that in turn acts as a repressor. Distributed toggle switch can exhibit mobile fronts, switching the system from the weaker to the stronger spatially homogeneous state. The circuit can also act as a biosensor, with the switching front dynamics determined by the properties of an external signal. Distributed oscillator system displays another biosensor functionality: oscillations emerge once a small amount of one cell strain appears amid the other, present in abundance. Distribution of synthetic gene circuits among multiple strains allows one to reduce crosstalk among different parts of the overall system and also decrease the energetic burden of the synthetic circuit per cell, which may allow for enhanced functionality and viability of engineered cells.

  2. Short circuit protection for a power distribution system

    NASA Technical Reports Server (NTRS)

    Owen, J. R., III

    1969-01-01

    Sensing circuit detects when the output from a matrix is present and when it should be present. The circuit provides short circuit protection for a power distribution system where the selection of the driven load is accomplished by digital logic.

  3. Safety and performance enhancement circuit for primary explosive detonators

    DOEpatents

    Davis, Ronald W.

    2006-04-04

    A safety and performance enhancement arrangement for primary explosive detonators. This arrangement involves a circuit containing an energy storage capacitor and preset self-trigger to protect the primary explosive detonator from electrostatic discharge (ESD). The circuit does not discharge into the detonator until a sufficient level of charge is acquired on the capacitor. The circuit parameters are designed so that normal ESD environments cannot charge the protection circuit to a level to achieve discharge. When functioned, the performance of the detonator is also improved because of the close coupling of the stored energy.

  4. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 7 2012-07-01 2012-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  5. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  6. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 7 2011-07-01 2011-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  7. 46 CFR 169.682 - Distribution and circuit loads.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Distribution and circuit loads. 169.682 Section 169.682... Less Than 100 Gross Tons § 169.682 Distribution and circuit loads. (a) Except as provided in paragraph (b) of this section, the connected load on a lighting branch circuit must not exceed 80 percent...

  8. 46 CFR 169.682 - Distribution and circuit loads.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Distribution and circuit loads. 169.682 Section 169.682... Less Than 100 Gross Tons § 169.682 Distribution and circuit loads. (a) Except as provided in paragraph (b) of this section, the connected load on a lighting branch circuit must not exceed 80 percent...

  9. 46 CFR 169.682 - Distribution and circuit loads.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Distribution and circuit loads. 169.682 Section 169.682... Less Than 100 Gross Tons § 169.682 Distribution and circuit loads. (a) Except as provided in paragraph (b) of this section, the connected load on a lighting branch circuit must not exceed 80 percent...

  10. 46 CFR 169.682 - Distribution and circuit loads.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Distribution and circuit loads. 169.682 Section 169.682... Less Than 100 Gross Tons § 169.682 Distribution and circuit loads. (a) Except as provided in paragraph (b) of this section, the connected load on a lighting branch circuit must not exceed 80 percent...

  11. 46 CFR 169.682 - Distribution and circuit loads.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Distribution and circuit loads. 169.682 Section 169.682... Less Than 100 Gross Tons § 169.682 Distribution and circuit loads. (a) Except as provided in paragraph (b) of this section, the connected load on a lighting branch circuit must not exceed 80 percent...

  12. Tracing Particle Size Distribution Curves Using an Analogue Circuit.

    ERIC Educational Resources Information Center

    Bisschop, F. De; Segaert, O.

    1986-01-01

    Proposes an analog circuit for use in sedimentation analysis of finely divided solid materials. Discusses a method of particle size distribution analysis and provides schematics of the circuit with list of components as well as a discussion about the operation of the circuit. (JM)

  13. High Resolution PV Power Modeling for Distribution Circuit Analysis

    SciTech Connect

    Norris, B. L.; Dise, J. H.

    2013-09-01

    NREL has contracted with Clean Power Research to provide 1-minute simulation datasets of PV systems located at three high penetration distribution feeders in the service territory of Southern California Edison (SCE): Porterville, Palmdale, and Fontana, California. The resulting PV simulations will be used to separately model the electrical circuits to determine the impacts of PV on circuit operations.

  14. Shuttle Electrical Power Analysis Program (SEPAP) distribution circuit analysis report

    NASA Technical Reports Server (NTRS)

    Torina, E. M.

    1975-01-01

    An analysis and evaluation was made of the operating parameters of the shuttle electrical power distribution circuit under load conditions encountered during a normal Sortie 2 Mission with emphasis on main periods of liftoff and landing.

  15. Synthesis for Negative Group Delay Circuits Using Distributed and Second-Order RC Circuit Configurations

    NASA Astrophysics Data System (ADS)

    Ahn, Kyoung-Pyo; Ishikawa, Ryo; Saitou, Akira; Honjo, Kazuhiko

    This paper describes the characteristic of negative group delay (NGD) circuits for various configurations including first-order, distributed, and second-order RC circuit configurations. This study includes locus, magnitude, and phase characteristics of the NGD circuits. The simplest NGD circuit is available using first-order RC or RL configuration. As an example of distributed circuit configuration, it is verified that losses in a distributed line causes NGD characteristic at higher cut-off band of a coupled four-line bandpass filter. Also, novel wideband NGD circuits using second-order RC configuration, instead of conventional RLC configuration, are proposed. Adding a parallel resistor to a parallel-T filter enables NGD characteristic to it. Also, a Wien-Robinson bridge is modified to have NGD characteristic by controlling the voltage division ratio. They are fabricated on MMIC substrate, and their NGD characteristics are verified with measured results. They have larger insertion loss than multi-stage RLC NGD circuits, however they can realize second-order NGD characteristic without practical implementation of inductors.

  16. Cognitive Consilience: Primate Non-Primary Neuroanatomical Circuits Underlying Cognition

    PubMed Central

    Solari, Soren Van Hout; Stoner, Rich

    2011-01-01

    Interactions between the cerebral cortex, thalamus, and basal ganglia form the basis of cognitive information processing in the mammalian brain. Understanding the principles of neuroanatomical organization in these structures is critical to understanding the functions they perform and ultimately how the human brain works. We have manually distilled and synthesized hundreds of primate neuroanatomy facts into a single interactive visualization. The resulting picture represents the fundamental neuroanatomical blueprint upon which cognitive functions must be implemented. Within this framework we hypothesize and detail 7 functional circuits corresponding to psychological perspectives on the brain: consolidated long-term declarative memory, short-term declarative memory, working memory/information processing, behavioral memory selection, behavioral memory output, cognitive control, and cortical information flow regulation. Each circuit is described in terms of distinguishable neuronal groups including the cerebral isocortex (9 pyramidal neuronal groups), parahippocampal gyrus and hippocampus, thalamus (4 neuronal groups), basal ganglia (7 neuronal groups), metencephalon, basal forebrain, and other subcortical nuclei. We focus on neuroanatomy related to primate non-primary cortical systems to elucidate the basis underlying the distinct homotypical cognitive architecture. To display the breadth of this review, we introduce a novel method of integrating and presenting data in multiple independent visualizations: an interactive website (http://www.frontiersin.org/files/cognitiveconsilience/index.html) and standalone iPhone and iPad applications. With these tools we present a unique, annotated view of neuroanatomical consilience (integration of knowledge). PMID:22194717

  17. Cognitive consilience: primate non-primary neuroanatomical circuits underlying cognition.

    PubMed

    Solari, Soren Van Hout; Stoner, Rich

    2011-01-01

    Interactions between the cerebral cortex, thalamus, and basal ganglia form the basis of cognitive information processing in the mammalian brain. Understanding the principles of neuroanatomical organization in these structures is critical to understanding the functions they perform and ultimately how the human brain works. We have manually distilled and synthesized hundreds of primate neuroanatomy facts into a single interactive visualization. The resulting picture represents the fundamental neuroanatomical blueprint upon which cognitive functions must be implemented. Within this framework we hypothesize and detail 7 functional circuits corresponding to psychological perspectives on the brain: consolidated long-term declarative memory, short-term declarative memory, working memory/information processing, behavioral memory selection, behavioral memory output, cognitive control, and cortical information flow regulation. Each circuit is described in terms of distinguishable neuronal groups including the cerebral isocortex (9 pyramidal neuronal groups), parahippocampal gyrus and hippocampus, thalamus (4 neuronal groups), basal ganglia (7 neuronal groups), metencephalon, basal forebrain, and other subcortical nuclei. We focus on neuroanatomy related to primate non-primary cortical systems to elucidate the basis underlying the distinct homotypical cognitive architecture. To display the breadth of this review, we introduce a novel method of integrating and presenting data in multiple independent visualizations: an interactive website (http://www.frontiersin.org/files/cognitiveconsilience/index.html) and standalone iPhone and iPad applications. With these tools we present a unique, annotated view of neuroanatomical consilience (integration of knowledge). PMID:22194717

  18. A high-precision synchronization circuit for clock distribution

    NASA Astrophysics Data System (ADS)

    Chong, Lu; Hongzhou, Tan; Zhikui, Duan; Yi, Ding

    2015-10-01

    In this paper, a novel structure of a high-precision synchronization circuit, HPSC, using interleaved delay units and a dynamic compensation circuit is proposed. HPSCs are designed for synchronization of clock distribution networks in large-scale integrated circuits, where high-quality clocks are required. The application of a hybrid structure of a coarse delay line and dynamic compensation circuit performs roughly the alignment of the clock signal in two clock cycles, and finishes the fine tuning in the next three clock cycles with the phase error suppressed under 3.8 ps. The proposed circuit is implemented and fabricated using a SMIC 0.13 μm 1P6M process with a supply voltage at 1.2 V. The allowed operation frequency ranges from 200 to 800 MHz, and the duty cycle ranges between [20%, 80%]. The active area of the core circuits is 245 × 134 μm2, and the power consumption is 1.64 mW at 500 MHz.

  19. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    S.K. Kawatra; T.C. Eisele; H.J. Walqui

    2002-10-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing he product size distribution, so that the amount of excessively fine material produced can be minimized. This will save energy by reducing the amount of material that is ground below the target size, and will also reduce the quantity of materials wasted as ''slimes'' that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production. In the seventh quarter of this project, analysis of the plant operation identified sources of overgrinding in the circuit. Overgrinding was primarily caused by two effects: (1) The hydrocyclones used to close the circuit and remove fully-ground particles from the circuit were preferentially returning high-density ore particles to the secondary mills for regrinding even after they were already ground to pass the desired product size, and (2) The primary grinding mills were operating at less than full capacity, suggesting that a shift of grinding load to the primary mills could liberate more material before it reached the secondary mills, allowing more complete liberation with a coarser grind. Circuit modeling is underway to determine how best to modify the circuit to reduce these effects.

  20. Distributed-element circuit model of edge magnetoplasmon transport

    NASA Astrophysics Data System (ADS)

    Hashisaka, Masayuki; Kamata, Hiroshi; Kumada, Norio; Washio, Kazuhisa; Murata, Ryuji; Muraki, Koji; Fujisawa, Toshimasa

    2013-12-01

    We report experimental and theoretical studies of edge magnetoplasmon (EMP) transport in quantum Hall (QH) devices. We develop a model that allows us to calculate the transport coefficients of EMPs in QH devices with various geometries. In our model, a QH system is described as a chiral distributed-element (CDE) circuit, where the effects of Coulomb interaction are represented by an electrochemical capacitance distributed along unidirectional transmission lines. We measure the EMP transport coefficients through single- and coupled-edge channels, a quantum point contact, and single- and double-cavity structures. These measured transmission spectra can be reproduced well by simulations using the corresponding CDE circuits. By fitting the experimental results with the simulations, we deduce the circuit parameters that characterize the electrostatic environment around the edge channels in a realistic QH system. The observed gate-voltage dependences of the EMP transport properties in gate-defined structures are explained in terms of the gate tuning of the circuit parameters in CDE circuits.

  1. Analysis of Distribution Circuits with High Penetrations of Photo-Voltaic Generation and Progressive Steps to Enable Higher Penetrations

    NASA Astrophysics Data System (ADS)

    Payne, Joshua Daniel

    Concern for anthropogenic climate change has instigated an increase in renewable generation capacity, including photo-voltaic (PV) power generation in distribution circuits. Distribution circuits with relatively high penetrations of PV generation (High-Pen PV) exist today, but how much more generation can distribution systems handle? This research aims to approach this question by 1) analyzing and quantifying High-Pen PV limitations on the primary circuits of distribution systems and 2) propose and analyze progressive steps to enable higher penetrations of PV on distribution circuits. Utilizing connectivity and load demand measurements provided by Pacific Gas & Electric (PG&E), time-resolved three-phase balanced feeder models of a commercial and a residential circuit featuring High-Pen PV were developed and calibrated to the point of the sub-station. Once calibrated, the circuit performance was simulated with varying PV penetrations and spatial distributions for typical seasonal high and seasonal low load demand days. Circuit scenarios with the Generation Center located downstream of the Load Center and with high impedance distribution line in-between lead to high voltage conditions. High-Pen PV interacting with the sub-station Load Drop Compensation (LDC) resulted an increased number of equipment operations and low voltage conditions on the circuit. As PV penetration increased, sub-station power factor and line loss decreased until reverse power flow became dominant. These were observed characteristics of High-Pen PV circuits. To overcome the limitations stated above, practical steps, such as line re-conductoring, and progressive control and operation changes were introduced. The progressive changes included using a Voltage Rise Siting (VRS) score for planning and LDC Current Compensation control to enable higher penetrations of PV. It was shown that limitations of High-Pen PV on the primary side of distribution circuits may be overcome via these practical and

  2. Engine Tune-Up Service. Unit 3: Primary Circuit. Student Guide. Automotive Mechanics Curriculum.

    ERIC Educational Resources Information Center

    Bacon, E. Miles

    This student guide is for Unit 3, Primary Circuit, in the Engine Tune-Up Service portion of the Automotive Mechanics Curriculum. It deals with how to test the primary ignition circuit. A companion review exercise book and posttests are available separately as CE 031 212-213. An introduction tells how this unit fits into the total tune-up service,…

  3. HEMP interaction with an electric power distribution circuit. Final report

    SciTech Connect

    Zaininger, H.W.; Jaszewski, G.M.

    1985-08-01

    A high altitude nuclear burst, detonated at a height of 50 km or more, causes two types of electromagnetic pulses, high altitude EMP (HEMP) and magnetohydrodynamic EMP, which will interact with electric power systems. Previous work indicated that millions of miles of electric distribution systems in the United States may be especially vulnerable to HEMP incident simultaneously throughout large portions of the United States. Purpose of this work was to perform an initial assessment of HEMP induced surges on a simplified electric distribution system. This report presents the assumptions, methodology, and resulting induced transient voltages and currents at various points in the distribution circuit in the microsecond timeframe, considering the impacts of HEMP incident simultaneously throughout the distribution system for a range of parametric conditions. Results of this work suggest that EMP could induce voltage transients that far exceed the basic insulation level (BIL) of distribution systems and that a more detailed analysis is warranted.

  4. 30 CFR 77.501 - Electric distribution circuits and equipment; repair.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Electric distribution circuits and equipment... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.501 Electric distribution circuits and equipment; repair. No electrical work shall be performed on electric distribution circuits or...

  5. 30 CFR 77.501 - Electric distribution circuits and equipment; repair.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Electric distribution circuits and equipment... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.501 Electric distribution circuits and equipment; repair. No electrical work shall be performed on electric distribution circuits or...

  6. 30 CFR 77.501 - Electric distribution circuits and equipment; repair.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Electric distribution circuits and equipment... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.501 Electric distribution circuits and equipment; repair. No electrical work shall be performed on electric distribution circuits or...

  7. 30 CFR 77.501 - Electric distribution circuits and equipment; repair.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Electric distribution circuits and equipment... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.501 Electric distribution circuits and equipment; repair. No electrical work shall be performed on electric distribution circuits or...

  8. 30 CFR 77.501 - Electric distribution circuits and equipment; repair.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Electric distribution circuits and equipment... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.501 Electric distribution circuits and equipment; repair. No electrical work shall be performed on electric distribution circuits or...

  9. Distributed control of reactive power flow in a radial distribution circuit with high photovoltaic penetration

    SciTech Connect

    Chertkov, Michael; Turitsyn, Konstantin; Backhaus, Scott; Sule, Petr

    2009-01-01

    We show how distributed control of reactive power can serve to regulate voltage and minimize resistive losses in a distribution circuit that includes a significant level of photovoltaic (PV) generation. To demonstrate the technique, we consider a radial distribution circuit with a single branch consisting of sequentially-arranged residential-scale loads that consume both real and reactive power. In parallel, some loads also have PV generation capability. We postulate that the inverters associated with each PV system are also capable of limited reactive power generation or consumption, and we seek to find the optimal dispatch of each inverter's reactive power to both maintain the voltage within an acceptable range and minimize the resistive losses over the entire circuit. We assume the complex impedance of the distribution circuit links and the instantaneous load and PV generation at each load are known. We compare the results of the optimal dispatch with a suboptimal local scheme that does not require any communication. On our model distribution circuit, we illustrate the feasibility of high levels of PV penetration and a significant (20% or higher) reduction in losses.

  10. Energy distribution in quantized mesoscopic RLC electric circuit

    NASA Astrophysics Data System (ADS)

    Wu, Wei-Feng; Fan, Hong-Yi

    2016-09-01

    Quantum information processing experimentally depends on optical-electronic devices. In this paper, we consider quantized mesoscopic RLC (resistance, inductance and capacitance) electric circuit in stable case as a quantum statistical ensemble, and calculate energy distribution (i.e. the energy stored in inductance and capacitance as well as the energy consumed on the resistance). For this aim, we employ the technique of integration within ordered product (IWOP) of operator to derive the thermo-vacuum state for this mesoscopic system, with which ensemble average energy calculation is replaced by evaluating expected value in pure state. This approach is concise and the result we deduced is physically appealling.

  11. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... employee is permitted to work on an electrical circuit, except when the circuit must remain energized for testing and adjusting, the circuit shall be deenergized and checked at the point at which the work is to be done to insure that it is actually deenergized. When testing or adjusting an energized circuit...

  12. Multi-input distributed classifiers for synthetic genetic circuits.

    PubMed

    Kanakov, Oleg; Kotelnikov, Roman; Alsaedi, Ahmed; Tsimring, Lev; Huerta, Ramón; Zaikin, Alexey; Ivanchenko, Mikhail

    2015-01-01

    For practical construction of complex synthetic genetic networks able to perform elaborate functions it is important to have a pool of relatively simple modules with different functionality which can be compounded together. To complement engineering of very different existing synthetic genetic devices such as switches, oscillators or logical gates, we propose and develop here a design of synthetic multi-input classifier based on a recently introduced distributed classifier concept. A heterogeneous population of cells acts as a single classifier, whose output is obtained by summarizing the outputs of individual cells. The learning ability is achieved by pruning the population, instead of tuning parameters of an individual cell. The present paper is focused on evaluating two possible schemes of multi-input gene classifier circuits. We demonstrate their suitability for implementing a multi-input distributed classifier capable of separating data which are inseparable for single-input classifiers, and characterize performance of the classifiers by analytical and numerical results. The simpler scheme implements a linear classifier in a single cell and is targeted at separable classification problems with simple class borders. A hard learning strategy is used to train a distributed classifier by removing from the population any cell answering incorrectly to at least one training example. The other scheme implements a circuit with a bell-shaped response in a single cell to allow potentially arbitrary shape of the classification border in the input space of a distributed classifier. Inseparable classification problems are addressed using soft learning strategy, characterized by probabilistic decision to keep or discard a cell at each training iteration. We expect that our classifier design contributes to the development of robust and predictable synthetic biosensors, which have the potential to affect applications in a lot of fields, including that of medicine and industry.

  13. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the switch, or removing the fuse, whichever method is appropriate. The circuit breaker, switch, or fuse location shall be tagged to indicate that an employee is working on the circuit. Such tags...

  14. Primary blast injury causes cognitive impairments and hippocampal circuit alterations.

    PubMed

    Beamer, Matthew; Tummala, Shanti R; Gullotti, David; Kopil, Catherine; Gorka, Samuel; Ted Abel; Bass, Cameron R Dale; Morrison, Barclay; Cohen, Akiva S; Meaney, David F

    2016-09-01

    Blast-induced traumatic brain injury (bTBI) and its long term consequences are a major health concern among veterans. Despite recent work enhancing our knowledge about bTBI, very little is known about the contribution of the blast wave alone to the observed sequelae. Herein, we isolated its contribution in a mouse model by constraining the animals' heads during exposure to a shockwave (primary blast). Our results show that exposure to primary blast alone results in changes in hippocampus-dependent behaviors that correspond with electrophysiological changes in area CA1 and are accompanied by reactive gliosis. Specifically, five days after exposure, behavior in an open field and performance in a spatial object recognition (SOR) task were significantly different from sham. Network electrophysiology, also performed five days after injury, demonstrated a significant decrease in excitability and increase in inhibitory tone. Immunohistochemistry for GFAP and Iba1 performed ten days after injury showed a significant increase in staining. Interestingly, a threefold increase in the impulse of the primary blast wave did not exacerbate these measures. However, we observed a significant reduction in the contribution of the NMDA receptors to the field EPSP at the highest blast exposure level. Our results emphasize the need to account for the effects of primary blast loading when studying the sequelae of bTBI.

  15. Primary blast injury causes cognitive impairments and hippocampal circuit alterations

    PubMed Central

    Beamer, Matthew; Tummala, Shanti R.; Gullotti, David; Kopil, Kathryn; Gorka, Samuel; Abel, Ted; “Dale” Bass, Cameron R.; Morrison, Barclay; Cohen, Akiva S.; Meaney, David F.

    2016-01-01

    Blast-induced traumatic brain injury (bTBI) and its long term consequences are a major health concern among veterans. Despite recent work enhancing our knowledge about bTBI, very little is known about the contribution of the blast wave alone to the observed sequelae. Herein, we isolated its contribution in a mouse model by constraining the animals' heads during exposure to a shockwave (primary blast). Our results show that exposure to primary blast alone results in changes in hippocampus-dependent behaviors that correspond with electro-physiological changes in area CA1 and are accompanied by reactive gliosis. Specifically, five days after exposure, behavior in an open field and performance in a spatial object recognition (SOR) task were significantly different from sham. Network electrophysiology, also performed five days after injury, demonstrated a significant decrease in excitability and increase in inhibitory tone. Immunohistochemistry for GFAP and Iba1 performed ten days after injury showed a significant increase in staining. Interestingly, a threefold increase in the impulse of the primary blast wave did not exacerbate these measures. However, we observed a significant reduction in the contribution of the NMDA receptors to the field EPSP at the highest blast exposure level. Our results emphasize the need to account for the effects of primary blast loading when studying the sequelae of bTBI. PMID:27246999

  16. 30 CFR 75.511 - Low-, medium-, or high-voltage distribution circuits and equipment; repair.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Low-, medium-, or high-voltage distribution... Electrical Equipment-General § 75.511 Low-, medium-, or high-voltage distribution circuits and equipment; repair. No electrical work shall be performed on low-, medium-, or high-voltage distribution circuits...

  17. 30 CFR 75.511 - Low-, medium-, or high-voltage distribution circuits and equipment; repair.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Low-, medium-, or high-voltage distribution... Electrical Equipment-General § 75.511 Low-, medium-, or high-voltage distribution circuits and equipment; repair. No electrical work shall be performed on low-, medium-, or high-voltage distribution circuits...

  18. 30 CFR 75.511 - Low-, medium-, or high-voltage distribution circuits and equipment; repair.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Low-, medium-, or high-voltage distribution... Electrical Equipment-General § 75.511 Low-, medium-, or high-voltage distribution circuits and equipment; repair. No electrical work shall be performed on low-, medium-, or high-voltage distribution circuits...

  19. 30 CFR 75.511 - Low-, medium-, or high-voltage distribution circuits and equipment; repair.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Low-, medium-, or high-voltage distribution... Electrical Equipment-General § 75.511 Low-, medium-, or high-voltage distribution circuits and equipment; repair. No electrical work shall be performed on low-, medium-, or high-voltage distribution circuits...

  20. 30 CFR 75.511 - Low-, medium-, or high-voltage distribution circuits and equipment; repair.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Low-, medium-, or high-voltage distribution... Electrical Equipment-General § 75.511 Low-, medium-, or high-voltage distribution circuits and equipment; repair. No electrical work shall be performed on low-, medium-, or high-voltage distribution circuits...

  1. Capabilities and Testing of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    NASA Technical Reports Server (NTRS)

    Garber, Anne E.

    2007-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, is currently undergoing testing in the Early Flight Fission Test Facility (EFF-TF). Sodium potassium (NaK), which was used in the SNAP-10A fission reactor, was selected as the primary coolant. Basic circuit components include: simulated reactor core, NaK to gas heat exchanger, electromagnetic (EM) liquid metal pump, liquid metal flowmeter, load/drain reservoir, expansion reservoir, test section, and instrumentation. Operation of the circuit is based around a 37-pin partial-array core (pin and flow path dimensions are the same as those in a full core), designed to operate at 33 kWt. NaK flow rates of greater than 1 kg/sec may be achieved, depending upon the power applied to the EM pump. The heat exchanger provides for the removal of thermal energy from the circuit, simulating the presence of an energy conversion system. The presence of the test section increases the versatility of the circuit. A second liquid metal pump, an energy conversion system, and highly instrumented thermal simulators are all being considered for inclusion within the test section. This paper summarizes the capabilities and ongoing testing of the Fission Surface Power Primary Test Circuit (FSP-PTC).

  2. Encoding of fear learning and memory in distributed neuronal circuits.

    PubMed

    Herry, Cyril; Johansen, Joshua P

    2014-12-01

    How sensory information is transformed by learning into adaptive behaviors is a fundamental question in neuroscience. Studies of auditory fear conditioning have revealed much about the formation and expression of emotional memories and have provided important insights into this question. Classical work focused on the amygdala as a central structure for fear conditioning. Recent advances, however, have identified new circuits and neural coding strategies mediating fear learning and the expression of fear behaviors. One area of research has identified key brain regions and neuronal coding mechanisms that regulate the formation, specificity and strength of fear memories. Other work has discovered critical circuits and neuronal dynamics by which fear memories are expressed through a medial prefrontal cortex pathway and coordinated activity across interconnected brain regions. Here we review these recent advances alongside prior work to provide a working model of the extended circuits and neuronal coding mechanisms mediating fear learning and memory.

  3. Encoding of fear learning and memory in distributed neuronal circuits.

    PubMed

    Herry, Cyril; Johansen, Joshua P

    2014-12-01

    How sensory information is transformed by learning into adaptive behaviors is a fundamental question in neuroscience. Studies of auditory fear conditioning have revealed much about the formation and expression of emotional memories and have provided important insights into this question. Classical work focused on the amygdala as a central structure for fear conditioning. Recent advances, however, have identified new circuits and neural coding strategies mediating fear learning and the expression of fear behaviors. One area of research has identified key brain regions and neuronal coding mechanisms that regulate the formation, specificity and strength of fear memories. Other work has discovered critical circuits and neuronal dynamics by which fear memories are expressed through a medial prefrontal cortex pathway and coordinated activity across interconnected brain regions. Here we review these recent advances alongside prior work to provide a working model of the extended circuits and neuronal coding mechanisms mediating fear learning and memory. PMID:25413091

  4. A dedicated circuit links direction-selective retinal ganglion cells to the primary visual cortex

    NASA Astrophysics Data System (ADS)

    Cruz-Martín, Alberto; El-Danaf, Rana N.; Osakada, Fumitaka; Sriram, Balaji; Dhande, Onkar S.; Nguyen, Phong L.; Callaway, Edward M.; Ghosh, Anirvan; Huberman, Andrew D.

    2014-03-01

    How specific features in the environment are represented within the brain is an important unanswered question in neuroscience. A subset of retinal neurons, called direction-selective ganglion cells (DSGCs), are specialized for detecting motion along specific axes of the visual field. Despite extensive study of the retinal circuitry that endows DSGCs with their unique tuning properties, their downstream circuitry in the brain and thus their contribution to visual processing has remained unclear. In mice, several different types of DSGCs connect to the dorsal lateral geniculate nucleus (dLGN), the visual thalamic structure that harbours cortical relay neurons. Whether direction-selective information computed at the level of the retina is routed to cortical circuits and integrated with other visual channels, however, is unknown. Here we show that there is a di-synaptic circuit linking DSGCs with the superficial layers of the primary visual cortex (V1) by using viral trans-synaptic circuit mapping and functional imaging of visually driven calcium signals in thalamocortical axons. This circuit pools information from several types of DSGCs, converges in a specialized subdivision of the dLGN, and delivers direction-tuned and orientation-tuned signals to superficial V1. Notably, this circuit is anatomically segregated from the retino-geniculo-cortical pathway carrying non-direction-tuned visual information to deeper layers of V1, such as layer 4. Thus, the mouse harbours several functionally specialized, parallel retino-geniculo-cortical pathways, one of which originates with retinal DSGCs and delivers direction- and orientation-tuned information specifically to the superficial layers of the primary visual cortex. These data provide evidence that direction and orientation selectivity of some V1 neurons may be influenced by the activation of DSGCs.

  5. A dedicated circuit links direction-selective retinal ganglion cells to the primary visual cortex.

    PubMed

    Cruz-Martín, Alberto; El-Danaf, Rana N; Osakada, Fumitaka; Sriram, Balaji; Dhande, Onkar S; Nguyen, Phong L; Callaway, Edward M; Ghosh, Anirvan; Huberman, Andrew D

    2014-03-20

    How specific features in the environment are represented within the brain is an important unanswered question in neuroscience. A subset of retinal neurons, called direction-selective ganglion cells (DSGCs), are specialized for detecting motion along specific axes of the visual field. Despite extensive study of the retinal circuitry that endows DSGCs with their unique tuning properties, their downstream circuitry in the brain and thus their contribution to visual processing has remained unclear. In mice, several different types of DSGCs connect to the dorsal lateral geniculate nucleus (dLGN), the visual thalamic structure that harbours cortical relay neurons. Whether direction-selective information computed at the level of the retina is routed to cortical circuits and integrated with other visual channels, however, is unknown. Here we show that there is a di-synaptic circuit linking DSGCs with the superficial layers of the primary visual cortex (V1) by using viral trans-synaptic circuit mapping and functional imaging of visually driven calcium signals in thalamocortical axons. This circuit pools information from several types of DSGCs, converges in a specialized subdivision of the dLGN, and delivers direction-tuned and orientation-tuned signals to superficial V1. Notably, this circuit is anatomically segregated from the retino-geniculo-cortical pathway carrying non-direction-tuned visual information to deeper layers of V1, such as layer 4. Thus, the mouse harbours several functionally specialized, parallel retino-geniculo-cortical pathways, one of which originates with retinal DSGCs and delivers direction- and orientation-tuned information specifically to the superficial layers of the primary visual cortex. These data provide evidence that direction and orientation selectivity of some V1 neurons may be influenced by the activation of DSGCs.

  6. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    S.K. Kawatra; T.C. Eisele; H.J. Walqui

    2002-07-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. This will save energy by reducing the amount of material that is ground below the target size, and will also reduce the quantity of materials wasted as slimes that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production. In the sixth quarter of this project, work was centered on analyzing the considerable plant data gathered during the first year of the project. Modeling is being carried out of the hydrocyclone portion of the grinding circuit, since this has been identified as the primary source of overgrinding and inefficiency.

  7. Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia.

    PubMed

    Tan, Rachel H; Wong, Stephanie; Kril, Jillian J; Piguet, Olivier; Hornberger, Michael; Hodges, John R; Halliday, Glenda M

    2014-07-01

    Despite accruing evidence for relative preservation of episodic memory in the semantic variant of primary progressive aphasia (previously semantic dementia), the neural basis for this remains unclear, particularly in light of their well-established hippocampal involvement. We recently investigated the Papez network of memory structures across pathological subtypes of behavioural variant frontotemporal dementia and demonstrated severe degeneration of all relay nodes, with the anterior thalamus in particular emerging as crucial for intact episodic memory. The present study investigated the status of key components of Papez circuit (hippocampus, mammillary bodies, anterior thalamus, cingulate cortex) and anterior temporal cortex using volumetric and quantitative cell counting methods in pathologically-confirmed cases with semantic variant of primary progressive aphasia (n = 8; 61-83 years; three males), behavioural variant frontotemporal dementia with TDP pathology (n = 9; 53-82 years; six males) and healthy controls (n = 8, 50-86 years; four males). Behavioural variant frontotemporal dementia cases with TDP pathology were selected because of the association between the semantic variant of primary progressive aphasia and TDP pathology. Our findings revealed that the semantic variant of primary progressive aphasia and behavioural variant frontotemporal dementia show similar degrees of anterior thalamic atrophy. The mammillary bodies and hippocampal body and tail were preserved in the semantic variant of primary progressive aphasia but were significantly atrophic in behavioural variant frontotemporal dementia. Importantly, atrophy in the anterior thalamus and mild progressive atrophy in the body of the hippocampus emerged as the main memory circuit regions correlated with increasing dementia severity in the semantic variant of primary progressive aphasia. Quantitation of neuronal populations in the cingulate cortices confirmed the selective loss of anterior cingulate

  8. Quantum circuit for optimal eavesdropping in quantum key distribution using phase-time coding

    SciTech Connect

    Kronberg, D. A.; Molotkov, S. N.

    2010-07-15

    A quantum circuit is constructed for optimal eavesdropping on quantum key distribution proto- cols using phase-time coding, and its physical implementation based on linear and nonlinear fiber-optic components is proposed.

  9. Low-power clock distribution circuits for the Macro Pixel ASIC

    NASA Astrophysics Data System (ADS)

    Gaioni, L.; De Canio, F.; Manghisoni, M.; Ratti, L.; Re, V.; Traversi, G.; Marchioro, A.; Kloukinas, K.

    2015-01-01

    Clock distribution circuits account for a significant fraction of the power dissipation of the Macro Pixel ASIC (MPA), designed for the pixel layer readout of the so-called Pixel-Strip module in the innermost part of the CMS tracker at the HL-LHC. This work reviews different CMOS circuit architectures envisioned for low power clock distribution in the MPA. Two main topologies will be discussed, based on standard supply voltage and on auxiliary, reduced supply. Circuit performance, in terms of power consumption and speed, is evaluated for each of the proposed solutions and compared with that relevant to standard CMOS drivers.

  10. Design and test of clock distribution circuits for the Macro Pixel ASIC

    NASA Astrophysics Data System (ADS)

    Gaioni, L.; De Canio, F.; Manghisoni, M.; Ratti, L.; Re, V.; Traversi, G.

    2016-07-01

    Clock distribution circuits account for a significant fraction of the power dissipation of the Macro Pixel ASIC (MPA), designed for the pixel layer readout of the so-called Pixel-Strip module in the innermost part of the CMS tracker at the High Luminosity LHC. A test chip including low power clock distribution circuits of the MPA has been designed in a 65 nm CMOS technology and thoroughly tested. This work summarizes the experimental results relevant to the prototype chip, focusing particularly on the power and speed performance and compares such results with those coming from circuit simulations.

  11. Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex

    PubMed Central

    Sasaki, Ryoki; Miyaguchi, Shota; Kotan, Shinichi; Kojima, Sho; Kirimoto, Hikari; Onishi, Hideaki

    2016-01-01

    Here, we aimed to evaluate whether cathodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and primary somatosensory cortex (S1) can modulate cortical inhibitory circuits. Sixteen healthy subjects participated in this study. Cathodal tDCS was positioned over the left M1 (M1 cathodal) or left S1 (S1 cathodal) with an intensity of 1 mA for 10 min. Sham tDCS was applied for 10 min over the left M1 (sham). Motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) were recorded from the right abductor pollicis brevis (APB) muscle before the intervention (pre) and 10 and 30 min after the intervention (post 1 and post 2, respectively). Cortical inhibitory circuits were evaluated using short-interval intracortical inhibition (SICI) and short-latency afferent inhibition (SAI). M1 cathodal decreased single-pulse MEP amplitudes at post 1 and decreased SAI at post 1 and post 2; however, SICI did not exhibit any change. S1 cathodal and sham did not show any changes in MEP amplitudes at any of the three time points. These results demonstrated that cathodal tDCS over the M1 not only decreases the M1 excitability but also affects the cortical inhibitory circuits related to SAI. PMID:26869909

  12. Optical gain control of GaAs microwave monolithic integrated circuit distributed amplifier

    NASA Astrophysics Data System (ADS)

    Paolella, Arthur; Herczfeld, Peter R.

    1989-02-01

    An optical gain control circuit for controlling the gain of a GaAs MMIC distributed amplifier having a dc gain control is provided. Variable intensity light from a controlled LED is directed to the surface of a GaAs multi-finger FET by means of an optical fiber. The FET is gate biased to a point near pinch-off to maximize its light sensitivity and the drain and source of the FET are serially connected with a fixed resistance in a dc voltage divider circuit so that the output of the voltage divider circuit changes as a function of the change in light intensity of the LED. A MMIC operational amplifier connected in an inverter mode is coupled between the output of the voltage divider circuit and the dc gain control of the distributed amplifier to control the gain of that amplifier.

  13. Primary thermometry triad at 6 mK in mesoscopic circuits

    PubMed Central

    Iftikhar, Z.; Anthore, A.; Jezouin, S.; Parmentier, F. D.; Jin, Y.; Cavanna, A.; Ouerghi, A.; Gennser, U.; Pierre, F.

    2016-01-01

    Quantum physics emerge and develop as temperature is reduced. Although mesoscopic electrical circuits constitute an outstanding platform to explore quantum behaviour, the challenge in cooling the electrons impedes their potential. The strong coupling of such micrometre-scale devices with the measurement lines, combined with the weak coupling to the substrate, makes them extremely difficult to thermalize below 10 mK and imposes in situ thermometers. Here we demonstrate electronic quantum transport at 6 mK in micrometre-scale mesoscopic circuits. The thermometry methods are established by the comparison of three in situ primary thermometers, each involving a different underlying physics. The employed combination of quantum shot noise, quantum back action of a resistive circuit and conductance oscillations of a single-electron transistor covers a remarkably broad spectrum of mesoscopic phenomena. The experiment, performed in vacuum using a standard cryogen-free dilution refrigerator, paves the way towards the sub-millikelvin range with additional thermalization and refrigeration techniques. PMID:27659941

  14. Microwave circuit analysis and design by a massively distributed computing network

    NASA Astrophysics Data System (ADS)

    Vai, Mankuan; Prasad, Sheila

    1995-05-01

    The advances in microelectronic engineering have rendered massively distributed computing networks practical and affordable. This paper describes one application of this distributed computing paradigm to the analysis and design of microwave circuits. A distributed computing network, constructed in the form of a neural network, is developed to automate the operations typically performed on a normalized Smith chart. Examples showing the use of this computing network for impedance matching and stabilizing are provided.

  15. Miners' Misconceptions of Flow Distribution Within Circuits as a Factor Influencing Underground Mining Accidents.

    NASA Astrophysics Data System (ADS)

    Passaro, Perry David

    Misconceptions can be thought of as naive approaches to problem solving that are perceptually appealing but incorrect and inconsistent with scientific evidence (Piaget, 1929). One type of misconception involves flow distributions within circuits. This concept is important because miners' conceptual errors about flow distribution changes within complex circuits may be in part responsible for fatal mine disasters. Based on the theory that misconceptions of flow distribution changes within circuits were responsible for underground mine disasters involving mine ventilation circuits, a series of studies was undertaken with mining engineering students, professional mining engineers, as well as mine foremen, mine supervisors, mine rescue members, mine maintenance personnel, mining researchers and working miners to identify these conceptual errors and errors in mine ventilation procedures. Results indicate that misconceptions of flow distribution changes within circuits exist in over 70 percent of the subjects sampled. It is assumed that these misconceptions of flow distribution changes within circuits result in errors of judgment when miners are faced with inferring and changing ventilation arrangements when two or more mine sections are connected. Furthermore, it is assumed that these misconceptions are pervasive in the mining industry and may be responsible for at least two mine ventilation disasters. The findings of this study are consistent with Piaget's (1929) model of figurative and operative knowledge. This model states that misconceptions are in part due to a lack of knowledge of dynamic transformations and how to apply content information. Recommendations for future research include the development of an interactive expert system for training miners with ventilation arrangements. Such a system would meet the educational recommendations made by Piaget (1973b) by involving a hands-on approach that allows discovery, interaction, the opportunity to make mistakes and

  16. Development and Analysis of Cold Trap for Use in Fission Surface Power-Primary Test Circuit

    NASA Technical Reports Server (NTRS)

    Wolfe, T. M.; Dervan, C. A.; Pearson, J. B.; Godfroy, T. J.

    2012-01-01

    The design and analysis of a cold trap proposed for use in the purification of circulated eutectic sodium potassium (NaK-78) loops is presented. The cold trap is designed to be incorporated into the Fission Surface Power-Primary Test Circuit (FSP-PTC), which incorporates a pumped NaK loop to simulate in-space nuclear reactor-based technology using non-nuclear test methodology as developed by the Early Flight Fission-Test Facility. The FSP-PTC provides a test circuit for the development of fission surface power technology. This system operates at temperatures that would be similar to those found in a reactor (500-800 K). By dropping the operating temperature of a specified percentage of NaK flow through a bypass containing a forced circulation cold trap, the NaK purity level can be increased by precipitating oxides from the NaK and capturing them within the cold trap. This would prevent recirculation of these oxides back through the system, which may help prevent corrosion.

  17. The universal fuzzy logical framework of neural circuits and its application in modeling primary visual cortex.

    PubMed

    Hu, Hong; Li, Su; Wang, YunJiu; Qi, XiangLin; Shi, ZhongZhi

    2008-10-01

    Analytical study of large-scale nonlinear neural circuits is a difficult task. Here we analyze the function of neural systems by probing the fuzzy logical framework of the neural cells' dynamical equations. Although there is a close relation between the theories of fuzzy logical systems and neural systems and many papers investigate this subject, most investigations focus on finding new functions of neural systems by hybridizing fuzzy logical and neural system. In this paper, the fuzzy logical framework of neural cells is used to understand the nonlinear dynamic attributes of a common neural system by abstracting the fuzzy logical framework of a neural cell. Our analysis enables the educated design of network models for classes of computation. As an example, a recurrent network model of the primary visual cortex has been built and tested using this approach.

  18. Radiation protection performance for the dismantling of the WWR-M primary cooling circuit.

    PubMed

    Lobach, Yu N; Luferenko, E D; Shevel, V N

    2014-12-01

    The WWR-M is a light-water-cooled and moderated heterogonous research reactor with a thermal output of 10 MW. The reactor has been in operation for >50 y and has had an excellent safety record. A non-hermeticity of the inlet line of the primary cooling circuit (PCC) was found, and the only reasonable technical solution was the complete replacement of the PCC inlet and outlet pipe lines. Such a replacement was a challenging technical task due to the necessity to handle large size components with complex geometries under conditions of high-level radiation fields, and therefore, it required detailed planning aiming to reduce staff exposure. This paper describes the dismantling and removal of the PCC components focusing on radiation protection issues.

  19. A Distributed Chemosensory Circuit for Oxygen Preference in C. elegans

    PubMed Central

    Chang, Andy J; Chronis, Nikolas; Karow, David S; Marletta, Michael A; Bargmann, Cornelia I

    2006-01-01

    The nematode Caenorhabditis elegans has complex, naturally variable behavioral responses to environmental oxygen, food, and other animals. C. elegans detects oxygen through soluble guanylate cyclase homologs (sGCs) and responds to it differently depending on the activity of the neuropeptide receptor NPR-1: npr-1(lf) and naturally isolated npr-1(215F) animals avoid high oxygen and aggregate in the presence of food; npr-1(215V) animals do not. We show here that hyperoxia avoidance integrates food with npr-1 activity through neuromodulation of a distributed oxygen-sensing network. Hyperoxia avoidance is stimulated by sGC-expressing oxygen-sensing neurons, nociceptive neurons, and ADF sensory neurons. In npr-1(215V) animals, the switch from weak aerotaxis on food to strong aerotaxis in its absence requires close regulation of the neurotransmitter serotonin in the ADF neurons; high levels of ADF serotonin promote hyperoxia avoidance. In npr-1(lf) animals, food regulation is masked by increased activity of the oxygen-sensing neurons. Hyperoxia avoidance is also regulated by the neuronal TGF-β homolog DAF-7, a secreted mediator of crowding and stress responses. DAF-7 inhibits serotonin synthesis in ADF, suggesting that ADF serotonin is a convergence point for regulation of hyperoxia avoidance. Coalitions of neurons that promote and repress hyperoxia avoidance generate a subtle and flexible response to environmental oxygen. PMID:16903785

  20. Mechanisms of coordination in distributed neural circuits: encoding coordinating information.

    PubMed

    Smarandache-Wellmann, Carmen; Grätsch, Swantje

    2014-04-16

    We describe synaptic connections through which information essential for encoding efference copies reaches two coordinating neurons in each of the microcircuits that controls limbs on abdominal segments of the crayfish, Pacifastacus leniusculus. In each microcircuit, these coordinating neurons fire bursts of spikes simultaneously with motor neurons. These bursts encode timing, duration, and strength of each motor burst. Using paired microelectrode recordings, we demonstrate that one class of nonspiking neurons in each microcircuit's pattern-generating kernel--IPS--directly inhibits the ASCE coordinating neuron that copies each burst in power-stroke (PS) motor neurons. This inhibitory synapse parallels IPS's inhibition of the same PS motor neurons. Using a disynaptic pathway to control its membrane potential, we demonstrate that a second type of nonspiking interneuron in the pattern-generating kernel--IRSh--inhibits the DSC coordinating neuron that copies each burst in return-stroke (RS) motor neurons. This inhibitory synapse parallels IRS's inhibition of the microcircuit's RS motor neurons. Experimental changes in the membrane potential of one IPS or one IRSh neuron simultaneously changed the strengths of motor bursts, durations, numbers of spikes, and spike frequency in the simultaneous ASCE and DSC bursts. ASCE and DSC coordinating neurons link the segmentally distributed microcircuits into a coordinated system that oscillates with the same period and with stable phase differences. The inhibitory synapses from different pattern-generating neurons that parallel their inhibition of different sets of motor neurons enable ASCE and DSC to encode details of each oscillation that are necessary for stable, adaptive synchronization of the system. PMID:24741053

  1. Formulating a simplified equivalent representation of distribution circuits for PV impact studies.

    SciTech Connect

    Reno, Matthew J.; Broderick, Robert Joseph; Grijalva, Santiago

    2013-04-01

    With an increasing number of Distributed Generation (DG) being connected on the distribution system, a method for simplifying the complexity of the distribution system to an equivalent representation of the feeder is advantageous for streamlining the interconnection study process. The general characteristics of the system can be retained while reducing the modeling effort required. This report presents a method of simplifying feeders to only specified buses-of-interest. These buses-of-interest can be potential PV interconnection locations or buses where engineers want to verify a certain power quality. The equations and methodology are presented with mathematical proofs of the equivalence of the circuit reduction method. An example 15-bus feeder is shown with the parameters and intermediate example reduction steps to simplify the circuit to 4 buses. The reduced feeder is simulated using PowerWorld Simulator to validate that those buses operate with the same characteristics as the original circuit. Validation of the method is also performed for snapshot and time-series simulations with variable load and solar energy output data to validate the equivalent performance of the reduced circuit with the interconnection of PV.

  2. Accounting for a feature of the configuration of the loops in the primary circuit of VVER-440 reactors

    SciTech Connect

    Khazanov, A. L.

    2013-09-15

    A feature of the configuration of the loops of the primary circuit of VVER-440 reactors and its influence on the characteristics of the main circulation pumps are analyzed. It is proposed that differences in the characteristics of the main reactor circulation pumps be taken account during the design and operation of nuclear power plants.

  3. Optimization of Comminution Circuit Throughput and Product Size Distribution by Simulation and Control

    SciTech Connect

    S. K. Kawatra; T. C. Eisele; T. Weldum; D. Larsen; R. Mariani; J. Pletka

    2005-03-31

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. The goal is to save energy by reducing the amount of material that is ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that are too fine to be useful. This is being accomplished by mathematical modeling of the grinding circuits to determine how to correct this problem. The approaches taken included (1) Modeling of the circuit to determine process bottlenecks that restrict flow rates in one area while forcing other parts of the circuit to overgrind the material; (2) Modeling of hydrocyclones to determine the mechanisms responsible for retaining fine, high-density particles in the circuit until they are overground, and improving existing models to accurately account for this behavior; and (3) Evaluation of advanced technologies to improve comminution efficiency and produce sharper product size distributions with less overgrinding.

  4. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    T.C. Eisele; S.K. Kawatra; H.J. Walqui

    2004-10-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. The goal is to save energy by reducing the amount of material that is ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that are too fine to be useful. This is being accomplished by mathematical modeling of the grinding circuits to determine how to correct this problem. The approaches taken included (1) Modeling of the circuit to determine process bottlenecks that restrict flowrates in one area while forcing other parts of the circuit to overgrind the material; (2) Modeling of hydrocyclones to determine the mechanisms responsible for retaining fine, high-density particles in the circuit until they are overground, and improving existing models to accurately account for this behavior; and (3) Evaluation of advanced technologies to improve comminution efficiency and produce sharper product size distributions with less overgrinding.

  5. Kinetic and Statistical Analysis of Primary Circuit Water Chemistry Data in a VVER Power Plant

    SciTech Connect

    Nagy, Gabor; Tilky, Peter; Horvath, Akos; Pinter, Tamas; Schiller, Robert

    2001-12-15

    The results of chemical and radiochemical analyses of the primary circuit coolant liquid, obtained between 1995 and 1999 at the four VVER-type blocks of the Paks (Hungary) nuclear power station, are assessed. A model has been developed regarding the pressure vessel with its auxiliary parts plus the fuel elements as the zone, with the six steam generators as one single unit. The stream from the steam generator is split, with its larger part returning to the zone through the main circulating pump and the smaller one passing through the purifier column. Based on this flowchart, the formation kinetics of corrosion products and of radioactive substances are evaluated. Correlation analysis is applied to reveal any eventual interdependence of the processes, whereas the range-per-scatter (R/S) method is used to characterize the random or deterministic nature of a process. The evaluation of the t {yields} {infinity} limits of the kinetic equations enables one to conclude that (a) the total amount of corrosion products per element during one cycle is almost always <15 kg and (b) the zone acts as a highly efficient filter with an efficiency of {approx}1. The R/S results show that the fluctuations in the concentrations of the corrosion products are persistent; this finding indicates that random effects play here little if any role and that the processes in the coolant are under control. Correlation analyses show that the variations of the concentrations are practically uncorrelated and that the processes are independent of each other.

  6. Effects of molybdenum and silver on iodine transport in primary circuit on severe nuclear accidents

    SciTech Connect

    Kalilainen, J.; Rantanen, P.; Karkela, T.; Lipponen, M.; Auvinen, A.; Jokiniemi, J.

    2012-07-01

    This experimental study was a continuation of the study conducted at VTT to investigate the effects of reactions on primary circuit surfaces to transport of gaseous and aerosol phase iodine during the hypothetical severe nuclear accident. Cesium iodide was used as a precursor in every experiment. In the experiments it was observed that the hydrogen in the atmosphere decreased the fraction of released gaseous iodine. As the temperature was lowered, less iodine was released, but the fraction of gaseous iodine from the overall released iodine was increased. As molybdenum trioxide was introduced to the precursor, the fraction of gaseous iodine from the overall released iodine was increased significantly. Also, Mo decreased the transport of Cs and caused significant depositions to the reaction furnace. Addition of silver to the CsI precursor at 650 deg. C decreased the release of iodine as well as the fraction of gaseous iodine. At 400 deg. C, Ag + CsI as well as Ag + MoO{sub 3} + CsI precursor significantly increased the release of gaseous iodine, where almost no aerosol particles were released. With B{sub 2}O{sub 3} + CsI precursor it was observed that in the atmosphere without H{sub 2}O, the released iodine was mostly in gaseous form. (authors)

  7. The primary visual cortex in the neural circuit for visual orienting

    NASA Astrophysics Data System (ADS)

    Zhaoping, Li

    The primary visual cortex (V1) is traditionally viewed as remote from influencing brain's motor outputs. However, V1 provides the most abundant cortical inputs directly to the sensory layers of superior colliculus (SC), a midbrain structure to command visual orienting such as shifting gaze and turning heads. I will show physiological, anatomical, and behavioral data suggesting that V1 transforms visual input into a saliency map to guide a class of visual orienting that is reflexive or involuntary. In particular, V1 receives a retinotopic map of visual features, such as orientation, color, and motion direction of local visual inputs; local interactions between V1 neurons perform a local-to-global computation to arrive at a saliency map that highlights conspicuous visual locations by higher V1 responses. The conspicuous location are usually, but not always, where visual input statistics changes. The population V1 outputs to SC, which is also retinotopic, enables SC to locate, by lateral inhibition between SC neurons, the most salient location as the saccadic target. Experimental tests of this hypothesis will be shown. Variations of the neural circuit for visual orienting across animal species, with more or less V1 involvement, will be discussed. Supported by the Gatsby Charitable Foundation.

  8. Optimization of Comminution Circuit Throughput and Product Size Distribution by Simulation and Control

    SciTech Connect

    S.K. Kawatra; T.C. Eisele; T. Weldum; D. Larsen; R. Mariani; J. Pletka

    2005-07-01

    The goal of this project was to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process were used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced could be minimized. The goal was to save energy by reducing the amount of material that was ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that were too fine to be useful. Extensive plant sampling and mathematical modeling of the grinding circuits was carried out to determine how to correct this problem. The approaches taken included (1) Modeling of the circuit to determine process bottlenecks that restrict flowrates in one area while forcing other parts of the circuit to overgrind the material; (2) Modeling of hydrocyclones to determine the mechanisms responsible for retaining fine, high-density particles in the circuit until they are overground, and improving existing models to accurately account for this behavior; and (3) Evaluation of the potential of advanced technologies to improve comminution efficiency and produce sharper product size distributions with less overgrinding. The mathematical models were used to simulate novel circuits for minimizing overgrinding and increasing throughput, and it is estimated that a single plant grinding 15 million tons of ore per year saves up to 82.5 million kWhr/year, or 8.6 x 10{sup 11} BTU/year. Implementation of this technology in the midwestern iron ore industry, which grinds an estimated 150 million tons of ore annually to produce over 50 million tons of iron ore concentrate, would save an estimated 1 x 10{sup 13} BTU/year.

  9. Spherical particles and voids effect on current and potential distribution in integrated circuit leads

    NASA Astrophysics Data System (ADS)

    Pang, Dongqing; Sun, Yicai

    2015-06-01

    Relationships of resistance with a width of 0.1 μm for different heights and currents at a given volt drop are plotted for a 0.2 μm length smooth copper lead. The lead is specified to connect with the integrated circuit AD8622 with its Isr = 0.350 mA to determine the volt drop = 0.2 mV. The total current is computed according to the total resistance of the lead for the different void radius at this volt drop. The current density value at the right boundary is determined by Ohm’s law. After combining the integration of the total current as a prerequisite with the interpolation of current density values from the left, i.e. void edge to the right boundaries, their distribution is obtained, showing current crowding outside of their edges and a great resistance with the increase of their radius. The calculation errors for comparison with the Laplace equation are calculated, mainly located on the corners of void. The potential distribution can be obtained by multiplying sheet resistance to current density distribution. At last, the relationship between resistance, total current, current crowding and calculation errors with the different void radius and lead length are offered in several forms for use in the integrated circuit design.

  10. Primary migration within the Querecual formation: Distribution of biomarkers

    SciTech Connect

    Lopez, L.; Sequera, Z.; Galarraga, F.

    1996-08-01

    Variations in the distribution of biomarkers (steranes and terpanes) as the consequences of primary migration were studied in limestone samples of the type section of the Querecual Formation, Venezuela. These variations were compared with conventional parameters of primary migration such as, variations in concentrations of bitumen, its fractions (saturated hydrocarbons, aromatic hydrocarbons, resins and asphaltene), and the n-alkane distribution. Biomarkers; (steranes and terpanes) show variations along the stratigraphic section that allow the suggestion of the following relative mobility of compounds in the consequence of their primary migration: Tricyclic Terpanes > regular Steranes =(approx.)= Rearranged Steranes > Pentacyclic Terpanes. Variations of bitumen fractions indicate a greater mobility of saturated and aromatic hydrocarbons vs. resins and asphaltenes, and variations in the n-alkane distribution indicate a relative greater migration of the light n-alkanes (n-C{sub 20}). These results indicate that primary migration was controlled by the molecular weight and structure of bitumen constituents. The migration tendencies of all geochemical parameters studied point to a vertical migration from the center toward the top and bottom of the type section of the Querecual Formation.

  11. Modifications to the Fission Surface Power Primary Test Circuit (FSP-PTC)

    NASA Technical Reports Server (NTRS)

    Garber, Anne E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of a closeable orifice in the test section. Modifications are now complete and testing has resumed. Performance of the ALIp, provided by Idaho National Laboratory (INL), is the subject of the first round ofexperimentation. This paper provides a summary of the tests conducted on the original circuit, details the physical changes that have since been made to it, and describes the current test program.

  12. Applying wind turbines and battery storage to defer Orcas Power and Light Company distribution circuit upgrades

    SciTech Connect

    Zaininger, H.W.; Barnes, P.R.

    1997-03-01

    The purpose of this study is to conduct a detailed assessment of the Orcas Power and Light Company (OPALCO) system to determine the potential for deferring the costly upgrade of the 25-kV Lopez- Eastsound circuit, by the application of a MW-scale wind farm and battery storage facilities as appropriate. Local wind resource data has been collected over the past year and used to determine MW-scale wind farm performance. This hourly wind farm performance data is used with measured hourly Eastsound load data, and recent OPALCO distribution system expansion plans and cost projections in performing this detailed benefit-cost assessment. The OPALCO distribution circuit expansion project and assumptions are described. MW-scale wind farm performance results are given. The economic benefit-cost results for the wind farm and battery storage applications on the OPALCO system using OPALCO system design criteria and cost assumptions are reported. A recalculation is presented of the benefit-cost results for similar potential wind farm and battery storage applications on other utility systems with higher marginal energy and demand costs. Conclusions and recommendations are presented.

  13. Competition with Primary Sensory Afferents Drives Remodeling of Corticospinal Axons in Mature Spinal Motor Circuits

    PubMed Central

    Jiang, Yu-Qiu; Zaaimi, Boubker

    2016-01-01

    Injury to the mature motor system drives significant spontaneous axonal sprouting instead of axon regeneration. Knowing the circuit-level determinants of axonal sprouting is important for repairing motor circuits after injury to achieve functional rehabilitation. Competitive interactions are known to shape corticospinal tract axon outgrowth and withdrawal during development. Whether and how competition contributes to reorganization of mature spinal motor circuits is unclear. To study this question, we examined plastic changes in corticospinal axons in response to two complementary proprioceptive afferent manipulations: (1) enhancing proprioceptive afferents activity by electrical stimulation; or (2) diminishing their input by dorsal rootlet rhizotomy. Experiments were conducted in adult rats. Electrical stimulation produced proprioceptive afferent sprouting that was accompanied by significant corticospinal axon withdrawal and a decrease in corticospinal connections on cholinergic interneurons in the medial intermediate zone and C boutons on motoneurons. In contrast, dorsal rootlet rhizotomy led to a significant increase in corticospinal connections, including those on cholinergic interneurons; C bouton density increased correspondingly. Motor cortex-evoked muscle potentials showed parallel changes to those of corticospinal axons, suggesting that reciprocal corticospinal axon changes are functional. Using the two complementary models, we showed that competitive interactions between proprioceptive and corticospinal axons are an important determinant in the organization of mature corticospinal axons and spinal motor circuits. The activity- and synaptic space-dependent properties of the competition enables prediction of the remodeling of spared corticospinal connection and spinal motor circuits after injury and informs the target-specific control of corticospinal connections to promote functional recovery. SIGNIFICANCE STATEMENT Neuroplasticity is limited in maturity

  14. Application of the leak-before-break concept to the primary circuit piping of the Leningrad NPP

    SciTech Connect

    Eperin, A.P.; Zakharzhevsky, Yu.O.; Arzhaev, A.I.

    1997-04-01

    A two-year Finnish-Russian cooperation program has been initiated in 1995 to demonstrate the applicability of the leak-before-break concept (LBB) to the primary circuit piping of the Leningrad NPP. The program includes J-R curve testing of authentic pipe materials at full operating temperature, screening and computational LBB analyses complying with the USNRC Standard Review Plan 3.6.3, and exchange of LBB-related information with emphasis on NDE. Domestic computer codes are mainly used, and all tests and analyses are independently carried out by each party. The results are believed to apply generally to RBMK type plants of the first generation.

  15. Recent Updates to the Fission Surface Power Primary Test Circuit (FSP-PTC)

    NASA Technical Reports Server (NTRS)

    Garber, Anne E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of a closeable orifice in the test section. Modifications are now complete and testing has resumed. Performance of the ALIP, provided by Idaho National Laboratory (1NL), is the subject of the first round of experimentation. This presentation details the physical changes made to the FSP-PTC and the current test program.

  16. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    H.J. Walqui; T.C. Eisele; S.K. Kawatra

    2003-07-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. The goal is to save energy by reducing the amount of material that is ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production.

  17. Experimental study of residence time distributions of ball-mill circuits grinding coal-water mixtures

    SciTech Connect

    Shoji, K.; Takahashi, Y.; Ohtake, A.; Austin, L.G.

    2008-08-15

    Residence time distributions (RTDs) were estimated by water tracing in a number of wet overflow ball mills (diameters 0.38 to 4.65 m) producing dense, coal-water slurries. In open-circuit mills of 0.38 m diameter and various length-diameter (LID) ratios, the mean residence times of solid were also determined from measured mill holdups. Holdup increased with increased mill feed rate, but the mean residence times of coal and water were still equal to each other. The experimental residence time distributions were fitted to the Mori-Jimbo-Yamazaki semi-infinite, axial mixing model, and the dimensionless mixing coefficient was determined for each of 25 tests in single- and two-compartment mills. This coefficient was found to be independent to the feed rate but linearly proportional to the D/L ratio. The mixing coefficient was smaller for two-compartment mills than for single-compartment mills, showing that there was reduced mixing introduced by the diaphragm separating the compartments. Equations are given to scale residence time distributions for changes in mill diameter and length.

  18. Vision Loss Shifts the Balance of Feedforward and Intracortical Circuits in Opposite Directions in Mouse Primary Auditory and Visual Cortices

    PubMed Central

    Petrus, Emily; Rodriguez, Gabriela; Patterson, Ryan; Connor, Blaine; Kanold, Patrick O.

    2015-01-01

    Loss of a sensory modality leads to widespread changes in synaptic function across sensory cortices, which are thought to be the basis for cross-modal adaptation. Previous studies suggest that experience-dependent cross-modal regulation of the spared sensory cortices may be mediated by changes in cortical circuits. Here, we report that loss of vision, in the form of dark exposure (DE) for 1 week, produces laminar-specific changes in excitatory and inhibitory circuits in the primary auditory cortex (A1) of adult mice to promote feedforward (FF) processing and also strengthens intracortical inputs to primary visual cortex (V1). Specifically, DE potentiated FF excitatory synapses from layer 4 (L4) to L2/3 in A1 and recurrent excitatory inputs in A1–L4 in parallel with a reduction in the strength of lateral intracortical excitatory inputs to A1–L2/3. This suggests a shift in processing in favor of FF information at the expense of intracortical processing. Vision loss also strengthened inhibitory synaptic function in L4 and L2/3 of A1, but via laminar specific mechanisms. In A1–L4, DE specifically potentiated the evoked synaptic transmission from parvalbumin-positive inhibitory interneurons to principal neurons without changes in spontaneous miniature IPSCs (mIPSCs). In contrast, DE specifically increased the frequency of mIPSCs in A1–L2/3. In V1, FF excitatory inputs were unaltered by DE, whereas lateral intracortical connections in L2/3 were strengthened, suggesting a shift toward intracortical processing. Our results suggest that loss of vision produces distinct circuit changes in the spared and deprived sensory cortices to shift between FF and intracortical processing to allow adaptation. PMID:26063913

  19. Contribution of polymers to classical primary insulation of distribution system

    SciTech Connect

    Shwehdi, M.H.; Al-Rawi, A.

    1996-12-31

    Insulation composites used on present distribution lines frequently consist of several types of materials such as wood, porcelain, polymers and fiberglass reinforced plastics (FRP) connected in series. A study included the laboratory determination of the critical flashover voltage (CFO) of 17 single component and 90 combinations of two components were conducted. The acquired data were used to develop methods of predicting CFO levels of various multiple series electrical insulations. This paper illustrates the results and analyses of the classical primary insulation (porcelain), and of the modern-day insulation of polymers. It also presents the result of whether polymers may add or supplement insulation strength to the two dielectric combination using statistical methods. The paper also presents advantages and guidelines for the use of polymers to either replace or complement porcelain. This may help optimize the choice of dielectrics on distribution lines.

  20. Modifications and Modelling of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    NASA Technical Reports Server (NTRS)

    Garber, Ann E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of the Single Flow Cell Test Apparatus (SFCTA) in the test section. Performance of the ALIP, provided by Idaho National Laboratory (INL), will be evaluated when testing resumes. The SFCTA, which will be tested simultaneously, will provide data on alkali metal flow behavior through the simulated core channels and assist in the development of a second generation thermal simulator. Additionally, data from the first round of testing has been used to refine the working system model, developed using the Generalized Fluid System Simulation Program (GFSSP). This paper covers the modifications of the FSP-PTC and the updated GFSSP system model.

  1. Spatial information outflow from the hippocampal circuit: distributed spatial coding and phase precession in the subiculum.

    PubMed

    Kim, Steve M; Ganguli, Surya; Frank, Loren M

    2012-08-22

    Hippocampal place cells convey spatial information through a combination of spatially selective firing and theta phase precession. The way in which this information influences regions like the subiculum that receive input from the hippocampus remains unclear. The subiculum receives direct inputs from area CA1 of the hippocampus and sends divergent output projections to many other parts of the brain, so we examined the firing patterns of rat subicular neurons. We found a substantial transformation in the subicular code for space from sparse to dense firing rate representations along a proximal-distal anatomical gradient: neurons in the proximal subiculum are more similar to canonical, sparsely firing hippocampal place cells, whereas neurons in the distal subiculum have higher firing rates and more distributed spatial firing patterns. Using information theory, we found that the more distributed spatial representation in the subiculum carries, on average, more information about spatial location and context than the sparse spatial representation in CA1. Remarkably, despite the disparate firing rate properties of subicular neurons, we found that neurons at all proximal-distal locations exhibit robust theta phase precession, with similar spiking oscillation frequencies as neurons in area CA1. Our findings suggest that the subiculum is specialized to compress sparse hippocampal spatial codes into highly informative distributed codes suitable for efficient communication to other brain regions. Moreover, despite this substantial compression, the subiculum maintains finer scale temporal properties that may allow it to participate in oscillatory phase coding and spike timing-dependent plasticity in coordination with other regions of the hippocampal circuit.

  2. Spatial information outflow from the hippocampal circuit: distributed spatial coding and phase precession in the subiculum

    PubMed Central

    Kim, Steve M.; Ganguli, Surya; Frank, Loren M.

    2012-01-01

    Hippocampal place cells convey spatial information through a combination of spatially-selective firing and theta phase precession. The way in which this information influences regions like the subiculum that receive input from the hippocampus remains unclear. The subiculum receives direct inputs from area CA1 of the hippocampus and sends divergent output projections to many other parts of the brain, so we examined the firing patterns of rat subicular neurons. We found a substantial transformation in the subicular code for space from sparse to dense firing rate representations along a proximal-distal anatomical gradient: neurons in the proximal subiculum are more similar to canonical, sparsely firing hippocampal place cells, whereas neurons in the distal subiculum have higher firing rates and more distributed spatial firing patterns. Using information theory, we found that the more distributed spatial representation in the subiculum carries, on average, more information about spatial location and context than the sparse spatial representation in CA1. Remarkably, despite the disparate firing rate properties of subicular neurons, we found that neurons at all proximal-distal locations exhibit robust theta phase precession, with similar spiking oscillation frequencies as neurons in area CA1. Our findings suggest that the subiculum is specialized to compress sparse hippocampal spatial codes into highly informative distributed codes suitable for efficient communication to other brain regions. Moreover, despite this substantial compression, the subiculum maintains finer scale temporal properties that may allow it to participate in oscillatory phase coding and spike timing-dependent plasticity in coordination with other regions of the hippocampal circuit. PMID:22915100

  3. Voltage Presented as a Primary Concept in an Introductory Teaching Sequence on DC Circuits.

    ERIC Educational Resources Information Center

    Psillos, Dimitris; And Others

    1988-01-01

    Discusses some difficulties in teaching the concept of voltage to secondary school students. Presents and describes the content of a teaching sequence introducing voltage as a primary concept through relationships with other variables. Provides an example of the delivery of the teaching model. (YP)

  4. Contrast-sensitive perceptual grouping and object-based attention in the laminar circuits of primary visual cortex.

    PubMed

    Grossberg, S; Raizada, R D

    2000-01-01

    Recent neurophysiological studies have shown that primary visual cortex, or V1, does more than passively process image features using the feedforward filters suggested by Hubel and Wiesel. It also uses horizontal interactions to group features preattentively into object representations, and feedback interactions to selectively attend to these groupings. All neocortical areas, including V1, are organized into layered circuits. We present a neural model showing how the layered circuits in areas V1 and V2 enable feedforward, horizontal, and feedback interactions to complete perceptual groupings over positions that do not receive contrastive visual inputs, even while attention can only modulate or prime positions that do not receive such inputs. Recent neurophysiological data about how grouping and attention occur and interact in V1 are simulated and explained, and testable predictions are made. These simulations show how attention can selectively propagate along an object grouping and protect it from competitive masking, and how contextual stimuli can enhance or suppress groupings in a contrast-sensitive manner. PMID:10788649

  5. Contrast-sensitive perceptual grouping and object-based attention in the laminar circuits of primary visual cortex.

    PubMed

    Grossberg, S; Raizada, R D

    2000-01-01

    Recent neurophysiological studies have shown that primary visual cortex, or V1, does more than passively process image features using the feedforward filters suggested by Hubel and Wiesel. It also uses horizontal interactions to group features preattentively into object representations, and feedback interactions to selectively attend to these groupings. All neocortical areas, including V1, are organized into layered circuits. We present a neural model showing how the layered circuits in areas V1 and V2 enable feedforward, horizontal, and feedback interactions to complete perceptual groupings over positions that do not receive contrastive visual inputs, even while attention can only modulate or prime positions that do not receive such inputs. Recent neurophysiological data about how grouping and attention occur and interact in V1 are simulated and explained, and testable predictions are made. These simulations show how attention can selectively propagate along an object grouping and protect it from competitive masking, and how contextual stimuli can enhance or suppress groupings in a contrast-sensitive manner.

  6. Effects of PbO on the oxide films of incoloy 800HT in simulated primary circuit of PWR

    NASA Astrophysics Data System (ADS)

    Tan, Yu; Yang, Junhan; Wang, Wanwan; Shi, Rongxue; Liang, Kexin; Zhang, Shenghan

    2016-05-01

    Effects of trace PbO on oxide films of Incoloy 800HT were investigated in simulated primary circuit water chemistry of PWR, also with proper Co addition. The trace PbO addition in high temperature water blocked the protective spinel oxides formation of the oxide films of Incoloy 800HT. XPS results indicated that the lead, added as PbO into the high temperature water, shows not only +2 valance but also +4 and 0 valances in the oxide film of 800HT co-operated with Fe, Cr and Ni to form oxides films. Potentiodynamic polarization results indicated that as PbO concentration increased, the current densities of the less protective oxide films of Incoloy 800HT decreased in a buffer solution tested at room temperature. The capacitance results indicated that the donor densities of oxidation film of Incoloy 800HT decreased as trace PbO addition into the high temperature water.

  7. [Speciation distribution characters of heavy metals in waste printed circuit boards].

    PubMed

    Zhao, Guo-hua; Luo, Xing-zhang; Huang, Zhuo-hui; Feng, Jing-wei; Zheng, Zheng; Gao, Shun-zhi; Nie, Er; Ni, Li-xiao

    2009-09-15

    The environmental availability of heavy metals from the waste printed circuit boards (PCBs) were studied through BCR's three-stage extraction procedures from EU and Tessier's five sequential extraction procedures. The results show that the heavy metal extraction rates with BCR's procedures are higher than that with Tessier's from waste PCBs. There are significant differences in fraction distributions of heavy metals in PCBs. The speciation of Ni in the PCBs exists mainly in residual forms and has little effect on the environment. The percentage of acidic extractable forms with BCR's method and the total amount of exchangeable and carbonate which bound for Tessier's procedure of Pb and Zn are high, in the South China, the two metals are more easily released by acid rain. Acidic extractable forms of Cu is the main speciation in PCBs with BCR's extraction procedures, while the percentage of Fe-Mn oxides- bound of Cu is the highest with Tessier's procedures, though the result is not agree consistent, due to the high content of Cu in PCBs, the harm of Cu from PCBs could not be neglected.

  8. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    S.K. Kawatra; T.C. Eisele; H.J. Walqui

    2001-12-01

    The goal of this project is to improve the energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. This will save energy by reducing the amount of material that is ground to below the target size, and will also reduce the quantity of material wasted as slimes that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production. In the first quarter of this project, work was completed on a basic comminution model that will be used to carry out the subsequent project tasks. This phase of the work was supported by the Electric Power Research Institute, as their cost-share contribution to the project. The model has been implemented as an Excel spreadsheet, which has the advantage of being a very portable format that can be made widely available to the industry once the project is completed.

  9. Low Insertion HVDC Circuit Breaker: Magnetically Pulsed Hybrid Breaker for HVDC Power Distribution Protection

    SciTech Connect

    2012-01-09

    GENI Project: General Atomics is developing a direct current (DC) circuit breaker that could protect the grid from faults 100 times faster than its alternating current (AC) counterparts. Circuit breakers are critical elements in any electrical system. At the grid level, their main function is to isolate parts of the grid where a fault has occurred—such as a downed power line or a transformer explosion—from the rest of the system. DC circuit breakers must interrupt the system during a fault much faster than AC circuit breakers to prevent possible damage to cables, converters and other grid-level components. General Atomics’ high-voltage DC circuit breaker would react in less than 1/1,000th of a second to interrupt current during a fault, preventing potential hazards to people and equipment.

  10. Quantum circuit for the proof of the security of quantum key distribution without encryption of error syndrome and noisy processing

    SciTech Connect

    Tamaki, Kiyoshi; Kato, Go

    2010-02-15

    One of the simplest security proofs of quantum key distribution is based on the so-called complementarity scenario, which involves the complementarity control of an actual protocol and a virtual protocol [M. Koashi, e-print arXiv:0704.3661 (2007)]. The existing virtual protocol has a limitation in classical postprocessing, i.e., the syndrome for the error-correction step has to be encrypted. In this paper, we remove this limitation by constructing a quantum circuit for the virtual protocol. Moreover, our circuit with a shield system gives an intuitive proof of why adding noise to the sifted key increases the bit error rate threshold in the general case in which one of the parties does not possess a qubit. Thus, our circuit bridges the simple proof and the use of wider classes of classical postprocessing.

  11. Distribution of lifespan gain from primary prevention intervention

    PubMed Central

    Finegold, Judith A; Shun-Shin, Matthew J; Cole, Graham D; Zaman, Saman; Maznyczka, Annette; Zaman, Sameer; Al-Lamee, Rasha; Ye, Siqin; Francis, Darrel P

    2016-01-01

    Objective When advising patients about possible initiation of primary prevention treatment, clinicians currently do not have information on expected impact on lifespan, nor how much this increment differs between individuals. Methods First, UK cardiovascular and non-cardiovascular mortality data were used to calculate the mean lifespan gain from an intervention (such as a statin) that reduces cardiovascular mortality by 30%. Second, a new method was developed to calculate the probability distribution of lifespan gain. Third, we performed a survey in three UK cities on 11 days between May–June 2014 involving 396 participants (mean age 40 years, 55% male) to assess how individuals evaluate potential benefit from primary prevention therapies. Results Among numerous identical patients, the lifespan gain, from an intervention that reduces cardiovascular mortality by 30%, is concentrated within an unpredictable minority. For example, men aged 50 years with national average cardiovascular risk have mean lifespan gain of 7 months. However, 93% of these identical individuals gain no lifespan, while the remaining 7% gain a mean of 99 months. Many survey respondents preferred a chance of large lifespan gain to the equivalent life expectancy gain given as certainty. Indeed, 33% preferred a 2% probability of 10 years to fivefold more gain, expressed as certainty of 1 year. Conclusions People who gain lifespan from preventative therapy gain far more than the average for their risk stratum, even if perfectly defined. This may be important in patient decision-making. Looking beyond mortality reduction alone from preventative therapy, the benefits are likely to be even larger. PMID:27042321

  12. Heterogeneous presynaptic distribution of monoacylglycerol lipase, a multipotent regulator of nociceptive circuits in the mouse spinal cord

    PubMed Central

    Horváth, Eszter; Woodhams, Stephen G; Nyilas, Rita; Henstridge, Christopher M; Kano, Masanobu; Sakimura, Kenji; Watanabe, Masahiko; Katona, István

    2014-01-01

    Monoacylglycerol lipase (MGL) is a multifunctional serine hydrolase, which terminates anti-nociceptive endocannabinoid signaling and promotes pro-nociceptive prostaglandin signaling. Accordingly, both acute nociception and its sensitization in chronic pain models are prevented by systemic or focal spinal inhibition of MGL activity. Despite its analgesic potential, the neurobiological substrates of beneficial MGL blockade have remained unexplored. Therefore, we examined the regional, cellular and subcellular distribution of MGL in spinal circuits involved in nociceptive processing. All immunohistochemical findings obtained with light, confocal or electron microscopy were validated in MGL-knockout mice. Immunoperoxidase staining revealed a highly concentrated accumulation of MGL in the dorsal horn, especially in superficial layers. Further electron microscopic analysis uncovered that the majority of MGL-immunolabeling is found in axon terminals forming either asymmetric glutamatergic or symmetric γ-aminobutyric acid/glycinergic synapses in laminae I/IIo. In line with this presynaptic localization, analysis of double-immunofluorescence staining by confocal microscopy showed that MGL colocalizes with neurochemical markers of peptidergic and non-peptidergic nociceptive terminals, and also with markers of local excitatory or inhibitory interneurons. Interestingly, the ratio of MGL-immunolabeling was highest in calcitonin gene-related peptide-positive peptidergic primary afferents, and the staining intensity of nociceptive terminals was significantly reduced in MGL-knockout mice. These observations highlight the spinal nociceptor synapse as a potential anatomical site for the analgesic effects of MGL blockade. Moreover, the presence of MGL in additional terminal types raises the possibility that MGL may play distinct regulatory roles in synaptic endocannabinoid or prostaglandin signaling according to its different cellular locations in the dorsal horn pain circuitry

  13. Mechanisms of Coordination in Distributed Neural Circuits: Decoding and Integration of Coordinating Information

    PubMed Central

    Smarandache-Wellmann, Carmen; Weller, Cynthia

    2014-01-01

    We describe the synaptic connections through which information required to coordinate limb movements reaches the modular microcircuits that control individual limbs on different abdominal segments of the crayfish, Pacifastacus leniusculus. In each segmental ganglion, a local commissural interneuron, ComInt 1, integrates information about other limbs and transmits it to one microcircuit. Five types of nonspiking local interneurons are components of each microcircuit's pattern-generating kernel (Smarandache-Wellmann et al., 2013). We demonstrate here, using paired microelectrode recordings, that the pathway through which information reaches this kernel is an electrical synapse between ComInt 1 and one of these five types, an IRSh interneuron. Using single-electrode voltage clamp, we show that brief changes of ComInt 1's membrane potential affect the timing of its microcircuit's motor output. Changing ComInt 1's membrane potential also changes the phase, duration, and strengths of bursts of spikes in its microcircuit's motor neurons and corresponding changes in its efferent coordinating neurons that project to other ganglia. These effects on coordinating neurons cause changes in the phases of motor output from other microcircuits in those distant ganglia. ComInt 1s function as hub neurons in the intersegmental circuit that synchronizes distributed microcircuits. The synapse between each ComInt 1 and its microcircuit's IRSh neuron completes a five synapse pathway in which analog information is encoded as a digital signal by efference-copy neurons and decoded from digital to analog form by ComInt 1. The synaptic organization of this pathway provides a cellular explanation of this nervous system's key dynamic properties. PMID:24431438

  14. The primary circuit materials properties results analysis performed on archive material used in NPP V-1 and Kola NPP Units 1 and 2

    SciTech Connect

    Kupca, L.; Beno, P.

    1997-04-01

    A very brief summary is provided of a primary circuit piping material properties analysis. The analysis was performed for the Bohunice V-1 reactor and the Kola-1 and -2 reactors. Assessment was performed on Bohunice V-1 archive materials and primary piping material cut from the Kola units after 100,000 hours of operation. Main research program tasks included analysis of mechanical properties, corrosion stability, and microstructural properties. Analysis results are not provided.

  15. Flotation rate and residence time distribution in continuous coal froth flotation circuits and an evaluation of reagents and circuit variations for pyritic sulfur removal

    SciTech Connect

    Arnold, B.J.

    1989-01-01

    This thesis gives the results of research conducted on several aspects of coal froth flotation. The effect of operating variables on the residence time distribution in coal froth flotation cells is discussed, and a model of the residence time distribution is presented for use with flotation rate models in scaling up from laboratory to plant scale. Flotation rate models are also investigated in detail for continuous coal froth flotation circuits. Changes in operating variables were found to affect the mean residence time in cells, but they did not have much effect on the mixing behavior. The use of a time lag was found to be an important part of rate models for continuous froth flotation cells. An important aspect of the use of such rate and residence time equations is their application to the flotation of gangue constituents, which often enter the froth by water carry-over in addition to natural flotation or flotation as slime coatings. As such, water carry-over is also investigated in this thesis for the laboratory and the plant and for both ash-forming minerals and pyrite. Maintaining a constant froth factor, the percentage of froth above the weir, in both laboratory and plant tests is believed to be a critical factor in predicting plant results using a kinetic factor ratio documented in the literature. Removing the pyrite and ash-forming minerals from coal that may be recovered by the water carry-over or other mechanisms is an important goal in coal froth flotation. This thesis also contains the results of tests with pyrite depressants and circuit variations for removal of pyritic sulfur.

  16. Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia

    PubMed Central

    Urrios, Arturo; de Nadal, Eulàlia; Solé, Ricard; Posas, Francesc

    2016-01-01

    Engineered synthetic biological devices have been designed to perform a variety of functions from sensing molecules and bioremediation to energy production and biomedicine. Notwithstanding, a major limitation of in vivo circuit implementation is the constraint associated to the use of standard methodologies for circuit design. Thus, future success of these devices depends on obtaining circuits with scalable complexity and reusable parts. Here we show how to build complex computational devices using multicellular consortia and space as key computational elements. This spatial modular design grants scalability since its general architecture is independent of the circuit’s complexity, minimizes wiring requirements and allows component reusability with minimal genetic engineering. The potential use of this approach is demonstrated by implementation of complex logical functions with up to six inputs, thus demonstrating the scalability and flexibility of this method. The potential implications of our results are outlined. PMID:26829588

  17. Subject Leadership in Primary Schools--Towards Distributed Practice

    ERIC Educational Resources Information Center

    Hammersley-Fletcher, Linda

    2004-01-01

    This paper is based on findings from the authors' PhD thesis looking at the role of Subject Leadership in primary schools. The study reports data collected from 20 subject leaders in 10 schools within 2 Local Education Authorities and sets the role of the subject leader within the context of a primary school, highlighting the varied complexities…

  18. Distribution of language-related Cntnap2 protein in neural circuits critical for vocal learning

    PubMed Central

    Condro, Michael C.; White, Stephanie A.

    2013-01-01

    Variants of the contactin associated protein-like 2 (Cntnap2) gene are risk factors for language-related disorders including autism spectrum disorder, specific language impairment, and stuttering. Songbirds are useful models for study of human speech disorders due to their shared capacity for vocal learning, which relies on similar cortico-basal ganglia circuitry and genetic factors. Here, we investigate Cntnap2 protein expression in the brain of the zebra finch, a songbird species in which males, but not females, learn their courtship songs. We hypothesize that Cntnap2 has overlapping functions in vocal learning species, and expect to find protein expression in song-related areas of the zebra finch brain. We further expect that the distribution of this membrane-bound protein may not completely mirror its mRNA distribution due to the distinct subcellular localization of the two molecular species. We find that Cntnap2 protein is enriched in several song control regions relative to surrounding tissues, particularly within the adult male, but not female, robust nucleus of the arcopallium (RA), a cortical song control region analogous to human layer 5 primary motor cortex. The onset of this sexually dimorphic expression coincides with the onset of sensorimotor learning in developing males. Enrichment in male RA appears due to expression in projection neurons within the nucleus, as well as to additional expression in nerve terminals of cortical projections to RA from the lateral magnocellular nucleus of the nidopallium. Cntnap2 protein expression in zebra finch brain supports the hypothesis that this molecule affects neural connectivity critical for vocal learning across taxonomic classes. PMID:23818387

  19. Network model and short circuit program for the Kennedy Space Center electric power distribution system

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Assumptions made and techniques used in modeling the power network to the 480 volt level are discussed. Basic computational techniques used in the short circuit program are described along with a flow diagram of the program and operational procedures. Procedures for incorporating network changes are included in this user's manual.

  20. Early Disruption of Extracellular Pleiotrophin Distribution Alters Cerebellar Neuronal Circuit Development and Function.

    PubMed

    Hamza, M M; Rey, S A; Hilber, P; Arabo, A; Collin, T; Vaudry, D; Burel, D

    2016-10-01

    The cerebellum is a structure of the central nervous system involved in balance, motor coordination, and voluntary movements. The elementary circuit implicated in the control of locomotion involves Purkinje cells, which receive excitatory inputs from parallel and climbing fibers, and are regulated by cerebellar interneurons. In mice as in human, the cerebellar cortex completes its development mainly after birth with the migration, differentiation, and synaptogenesis of granule cells. These cellular events are under the control of numerous extracellular matrix molecules including pleiotrophin (PTN). This cytokine has been shown to regulate the morphogenesis of Purkinje cells ex vivo and in vivo via its receptor PTPζ. Since Purkinje cells are the unique output of the cerebellar cortex, we explored the consequences of their PTN-induced atrophy on the function of the cerebellar neuronal circuit in mice. Behavioral experiments revealed that, despite a normal overall development, PTN-treated mice present a delay in the maturation of their flexion reflex. Moreover, patch clamp recording of Purkinje cells revealed a significant increase in the frequency of spontaneous excitatory postsynaptic currents in PTN-treated mice, associated with a decrease of climbing fiber innervations and an abnormal perisomatic localization of the parallel fiber contacts. At adulthood, PTN-treated mice exhibit coordination impairment on the rotarod test associated with an alteration of the synchronization gait. Altogether these histological, electrophysiological, and behavior data reveal that an early ECM disruption of PTN composition induces short- and long-term defaults in the establishment of proper functional cerebellar circuit.

  1. Early Disruption of Extracellular Pleiotrophin Distribution Alters Cerebellar Neuronal Circuit Development and Function.

    PubMed

    Hamza, M M; Rey, S A; Hilber, P; Arabo, A; Collin, T; Vaudry, D; Burel, D

    2016-10-01

    The cerebellum is a structure of the central nervous system involved in balance, motor coordination, and voluntary movements. The elementary circuit implicated in the control of locomotion involves Purkinje cells, which receive excitatory inputs from parallel and climbing fibers, and are regulated by cerebellar interneurons. In mice as in human, the cerebellar cortex completes its development mainly after birth with the migration, differentiation, and synaptogenesis of granule cells. These cellular events are under the control of numerous extracellular matrix molecules including pleiotrophin (PTN). This cytokine has been shown to regulate the morphogenesis of Purkinje cells ex vivo and in vivo via its receptor PTPζ. Since Purkinje cells are the unique output of the cerebellar cortex, we explored the consequences of their PTN-induced atrophy on the function of the cerebellar neuronal circuit in mice. Behavioral experiments revealed that, despite a normal overall development, PTN-treated mice present a delay in the maturation of their flexion reflex. Moreover, patch clamp recording of Purkinje cells revealed a significant increase in the frequency of spontaneous excitatory postsynaptic currents in PTN-treated mice, associated with a decrease of climbing fiber innervations and an abnormal perisomatic localization of the parallel fiber contacts. At adulthood, PTN-treated mice exhibit coordination impairment on the rotarod test associated with an alteration of the synchronization gait. Altogether these histological, electrophysiological, and behavior data reveal that an early ECM disruption of PTN composition induces short- and long-term defaults in the establishment of proper functional cerebellar circuit. PMID:26399645

  2. Long-tailed distribution of synaptic strength reveals origin and functional roles of ongoing fluctuation in cortical circuit

    NASA Astrophysics Data System (ADS)

    Teramae, Jun-nosuke

    2016-06-01

    Neurons in the cortical circuit continuous to generate irregular spike firing with extremely low firing rate (about 1-2 Hz) even when animals neither receive any external stimuli nor they do not show any significant motor movement. The ongoing activity is often called neuronal noise because measured spike trains are often highly irregular and also spike timings are highly asynchronous among neurons. Many experiments imply that neural networks themselves must generate the noisy activity as an intrinsic property of cortical circuit. However, how a network of neurons sustains the irregular spike firings with low firing rate remains unclear. Recently, by focusing on long-tailed distribution of amplitude of synaptic connections or EPSP (Excitatory Post-Synaptic Potential), we successfully revealed that due to coexistence of a few extremely strong synaptic connections and majority of weak synapses, nonlinear dynamics of population of spiking neurons can have a nontrivial stable state that corresponding to the intrinsic ongoing fluctuation of the cortical circuit. We also found that due to the fluctuation fidelity of spike transmission between neurons are optimized. Here, we report our recent findings of the ongoing fluctuation from viewpoints of mathematical and computational side.

  3. Preparation of Power Distribution System for High Penetration of Renewable Energy Part I. Dynamic Voltage Restorer for Voltage Regulation Pat II. Distribution Circuit Modeling and Validation

    NASA Astrophysics Data System (ADS)

    Khoshkbar Sadigh, Arash

    by simulation and experimental tests under various conditions considering all possible cases such as different amounts of voltage sag depth (VSD), different amounts of point-on-wave (POW) at which voltage sag occurs, harmonic distortion, line frequency variation, and phase jump (PJ). Furthermore, the ripple amount of fundamental voltage amplitude calculated by the proposed method and its error is analyzed considering the line frequency variation together with harmonic distortion. The best and worst detection time of proposed method were measured 1ms and 8.8ms, respectively. Finally, the proposed method has been compared with other voltage sag detection methods available in literature. Part 2: Power System Modeling for Renewable Energy Integration: As power distribution systems are evolving into more complex networks, electrical engineers have to rely on software tools to perform circuit analysis. There are dozens of powerful software tools available in the market to perform the power system studies. Although their main functions are similar, there are differences in features and formatting structures to suit specific applications. This creates challenges for transferring power system circuit models data (PSCMD) between different software and rebuilding the same circuit in the second software environment. The objective of this part of thesis is to develop a Unified Platform (UP) to facilitate transferring PSCMD among different software packages and relieve the challenges of the circuit model conversion process. UP uses a commonly available spreadsheet file with a defined format, for any home software to write data to and for any destination software to read data from, via a script-based application called PSCMD transfer application. The main considerations in developing the UP are to minimize manual intervention and import a one-line diagram into the destination software or export it from the source software, with all details to allow load flow, short circuit and

  4. Distributed Circuit Plasticity: New Clues for the Cerebellar Mechanisms of Learning.

    PubMed

    D'Angelo, Egidio; Mapelli, Lisa; Casellato, Claudia; Garrido, Jesus A; Luque, Niceto; Monaco, Jessica; Prestori, Francesca; Pedrocchi, Alessandra; Ros, Eduardo

    2016-04-01

    The cerebellum is involved in learning and memory of sensory motor skills. However, the way this process takes place in local microcircuits is still unclear. The initial proposal, casted into the Motor Learning Theory, suggested that learning had to occur at the parallel fiber-Purkinje cell synapse under supervision of climbing fibers. However, the uniqueness of this mechanism has been questioned, and multiple forms of long-term plasticity have been revealed at various locations in the cerebellar circuit, including synapses and neurons in the granular layer, molecular layer and deep-cerebellar nuclei. At present, more than 15 forms of plasticity have been reported. There has been a long debate on which plasticity is more relevant to specific aspects of learning, but this question turned out to be hard to answer using physiological analysis alone. Recent experiments and models making use of closed-loop robotic simulations are revealing a radically new view: one single form of plasticity is insufficient, while altogether, the different forms of plasticity can explain the multiplicity of properties characterizing cerebellar learning. These include multi-rate acquisition and extinction, reversibility, self-scalability, and generalization. Moreover, when the circuit embeds multiple forms of plasticity, it can easily cope with multiple behaviors endowing therefore the cerebellum with the properties needed to operate as an effective generalized forward controller.

  5. The Challenges of Distributing Leadership in Irish Post-Primary Schools

    ERIC Educational Resources Information Center

    O'Donovan, Margaret

    2015-01-01

    This study explores the challenges and opportunities in relation to developing distributed leadership practice in Irish post-primary schools. It considers school leadership within the context of contemporary distributed leadership theory. Associated concepts such as distributed cognition and activity theory are used to frame the study. The study…

  6. History of Physics as a Tool to Detect the Conceptual Difficulties Experienced by Students: The Case of Simple Electric Circuits in Primary Education

    NASA Astrophysics Data System (ADS)

    Leone, Matteo

    2014-04-01

    The present paper advocates the use of History of Science into the teaching of science in primary education through a case study in the field of electricity. In this study, which provides both historical and experimental evidence, a number of conceptual difficulties faced by early nineteenth century physicists are shown to be a useful tool to detect 5th grade pupils' conceptions about the simple electric circuits. This result was obtained through the administration of schematics showing circuital situation inspired to early 1800s experiments on the effects of electric current on water electrolysis and on the behaviour of magnetic compasses. It is also shown that the detecting of pupils' alternative ideas about electric current in a circuit is highly dependent on the survey methodology (open ended questions and drawings, multiple-choice item, connecting card work, and history of science tasks were considered in this study) and that the so-called "unipolar model" of electric circuit is more pervasive than previously acknowledged. Finally, a highly significant hybrid model of electric current is identified.

  7. Sparse Distributed Representation of Odors in a Large-scale Olfactory Bulb Circuit

    PubMed Central

    Yu, Yuguo; McTavish, Thomas S.; Hines, Michael L.; Shepherd, Gordon M.; Valenti, Cesare; Migliore, Michele

    2013-01-01

    In the olfactory bulb, lateral inhibition mediated by granule cells has been suggested to modulate the timing of mitral cell firing, thereby shaping the representation of input odorants. Current experimental techniques, however, do not enable a clear study of how the mitral-granule cell network sculpts odor inputs to represent odor information spatially and temporally. To address this critical step in the neural basis of odor recognition, we built a biophysical network model of mitral and granule cells, corresponding to 1/100th of the real system in the rat, and used direct experimental imaging data of glomeruli activated by various odors. The model allows the systematic investigation and generation of testable hypotheses of the functional mechanisms underlying odor representation in the olfactory bulb circuit. Specifically, we demonstrate that lateral inhibition emerges within the olfactory bulb network through recurrent dendrodendritic synapses when constrained by a range of balanced excitatory and inhibitory conductances. We find that the spatio-temporal dynamics of lateral inhibition plays a critical role in building the glomerular-related cell clusters observed in experiments, through the modulation of synaptic weights during odor training. Lateral inhibition also mediates the development of sparse and synchronized spiking patterns of mitral cells related to odor inputs within the network, with the frequency of these synchronized spiking patterns also modulated by the sniff cycle. PMID:23555237

  8. The Potential Distribution and the Short-Circuiting Factor in the Sucrose Gap

    PubMed Central

    Jirounek, P.; Straub, R. W.

    1971-01-01

    The sucrose gap technique, though widely employed in many tissues, could not be used for quantitative measurements of the membrane potential, because the value of the short-circuiting factor and the influence of junction potential on the recorded potential difference were unknown. The formula that relates the recorded potential to the true resting membrane potential was found by application of the cable equations to a core conductor placed in a system with three different media, e.g. Ringer, sucrose, and KCl. The formula shows that the potential difference recorded over the sucrose insulator depends on the extracellular and the intracellular longitudinal resistances, the membrane resistance and the membrane potentials in each region, and on the junction potentials between the different media. The true membrane potential in the Ringer region can be calculated from the potential difference recorded after complete depolarization by KCl on one side of the preparation, if the longitudinal resistances, the membrane resistances, the extracellular potential in the sucrose, and the junction potential between Ringer and sucrose are determined by separate measurements. PMID:5538998

  9. Electrical Circuit Simulation Code

    SciTech Connect

    Wix, Steven D.; Waters, Arlon J.; Shirley, David

    2001-08-09

    Massively-Parallel Electrical Circuit Simulation Code. CHILESPICE is a massively-arallel distributed-memory electrical circuit simulation tool that contains many enhanced radiation, time-based, and thermal features and models. Large scale electronic circuit simulation. Shared memory, parallel processing, enhance convergence. Sandia specific device models.

  10. Preparation of Power Distribution System for High Penetration of Renewable Energy Part I. Dynamic Voltage Restorer for Voltage Regulation Pat II. Distribution Circuit Modeling and Validation

    NASA Astrophysics Data System (ADS)

    Khoshkbar Sadigh, Arash

    by simulation and experimental tests under various conditions considering all possible cases such as different amounts of voltage sag depth (VSD), different amounts of point-on-wave (POW) at which voltage sag occurs, harmonic distortion, line frequency variation, and phase jump (PJ). Furthermore, the ripple amount of fundamental voltage amplitude calculated by the proposed method and its error is analyzed considering the line frequency variation together with harmonic distortion. The best and worst detection time of proposed method were measured 1ms and 8.8ms, respectively. Finally, the proposed method has been compared with other voltage sag detection methods available in literature. Part 2: Power System Modeling for Renewable Energy Integration: As power distribution systems are evolving into more complex networks, electrical engineers have to rely on software tools to perform circuit analysis. There are dozens of powerful software tools available in the market to perform the power system studies. Although their main functions are similar, there are differences in features and formatting structures to suit specific applications. This creates challenges for transferring power system circuit models data (PSCMD) between different software and rebuilding the same circuit in the second software environment. The objective of this part of thesis is to develop a Unified Platform (UP) to facilitate transferring PSCMD among different software packages and relieve the challenges of the circuit model conversion process. UP uses a commonly available spreadsheet file with a defined format, for any home software to write data to and for any destination software to read data from, via a script-based application called PSCMD transfer application. The main considerations in developing the UP are to minimize manual intervention and import a one-line diagram into the destination software or export it from the source software, with all details to allow load flow, short circuit and

  11. 3-Dimensional Multiwaveguide Probe Array for Light Delivery to Distributed Brain Circuits

    PubMed Central

    Zorzos, Anthony N.; Scholvin, Jorg; Boyden, Edward S.; Fonstad, Clifton G.

    2013-01-01

    To deliver light to the brain for neuroscientific and neuroengineering applications like optogenetics, in which light is used to activate or silence neurons expressing specific photosensitive proteins, optical fibers are commonly used. However, an optical fiber is limited to delivering light to a single target within the three-dimensional structure of the brain. We here describe the design and fabrication of an array of thin microwaveguides which terminate at a 3-dimensionally distributed set of points, appropriate for delivering light to targets distributed in a 3-dimensional pattern throughout the brain. PMID:23202064

  12. Theoretical and Experimental Study of the Primary Current Distribution in Parallel-Plate Electrochemical Reactors

    ERIC Educational Resources Information Center

    Vazquez Aranda, Armando I.; Henquin, Eduardo R.; Torres, Israel Rodriguez; Bisang, Jose M.

    2012-01-01

    A laboratory experiment is described to determine the primary current distribution in parallel-plate electrochemical reactors. The electrolyte is simulated by conductive paper and the electrodes are segmented to measure the current distribution. Experiments are reported with the electrolyte confined to the interelectrode gap, where the current…

  13. Primary-secondary pumping conversion: Retrofit of an existing campus chilled water distribution system

    SciTech Connect

    Sczomak, D.P.; Nguyen, P.N.

    1996-08-01

    The chilled water distribution system within an existing 8,300 ton (29,200 kW) capacity regional chilled water plant at Michigan State University (MSU) is being converted from a primary pumping arrangement to a primary-secondary arrangement. The plant presently provides chilled water for air conditioning to twelve remote buildings. In the future, MSU plans to increase the plant`s capacity to 10,800 tons (38,000 kW) in order to serve seven more buildings. The addition of buildings to the distribution system has caused the existing primary pumps to be incapable of producing enough pressure to offset system losses at design flow rates. The existing system has become unable to concurrently provide adequate flow, design supply water temperature and efficient chiller operation due to the distribution system deficiencies. The primary-secondary pumping conversion will include modifications to the distribution piping, the addition of five variable speed secondary pumps, additions and modifications to the control systems, the trimming of impellers on six of the existing primary pumps and replacement of two primary pumps. The campus central control system will be utilized to provide automatic chiller staging, interface with the packaged secondary pump control systems, and control of the building interconnections. The total construction cost is approximately $1,400,000 and is scheduled for completion prior to the 1996 cooling season. Provisions have been made for two additional secondary pumps to accommodate the connection of additional buildings to the distribution system in the future.

  14. Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain.

    PubMed

    Smith, Craig M; Shen, Pei-Juan; Banerjee, Avantika; Bonaventure, Pascal; Ma, Sherie; Bathgate, Ross A D; Sutton, Steven W; Gundlach, Andrew L

    2010-10-01

    Relaxin-3 (RLN3) and its native receptor, relaxin family peptide 3 receptor (RXFP3), constitute a newly identified neuropeptide system enriched in mammalian brain. The distribution of RLN3/RXFP3 networks in rat brain and recent experimental studies suggest a role for this system in modulation of arousal, stress, metabolism, and cognition. In order to facilitate exploration of the biology of RLN3/RXFP3 in complementary murine models, this study mapped the neuroanatomical distribution of the RLN3/RXFP3 system in mouse brain. Adult, male wildtype and RLN3 knock-out (KO)/LacZ knock-in (KI) mice were used to map the central distribution of RLN3 gene expression and RLN3-like immunoreactivity (-LI). The distribution of RXFP3 mRNA and protein was determined using [(35)S]-oligonucleotide probes and a radiolabeled RXFP3-selective agonist ([(125)I]-R3/I5), respectively. High densities of neurons expressing RLN3 mRNA, RLN3-associated beta-galactosidase activity and RLN3-LI were detected in the nucleus incertus (or nucleus O), while smaller populations of positive neurons were observed in the pontine raphé, the periaqueductal gray and a region adjacent to the lateral substantia nigra. RLN3-LI was observed in nerve fibers/terminals in nucleus incertus and broadly throughout the pons, midbrain, hypothalamus, thalamus, septum, hippocampus, and neocortex, but was absent in RLN3 KO/LacZ KI mice. This RLN3 neural network overlapped the regional distribution of RXFP3 mRNA and [(125)I]-R3/I5 binding sites in wildtype and RLN3 KO/LacZ KI mice. These findings provide further evidence for the conserved nature of RLN3/RXFP3 systems in mammalian brain and the ability of RLN3/RXFP3 signaling to modulate "behavioral state" and an array of circuits involved in arousal, stress responses, affective state, and cognition.

  15. TWO-PHASE FLOW STUDIES IN NUCLEAR POWER PLANT PRIMARY CIRCUITS USING THE THREE-DIMENSIONAL THERMAL-HYDRAULIC CODE BAGIRA.

    SciTech Connect

    KOHURT, P. , KALINICHENKO, S.D.; KROSHILIN, A.E.; KROSHILIN, V.E.; SMIRNOV, A.V.

    2006-06-04

    In this paper we present recent results of the application of the thermal-hydraulic code BAGIRA to the analysis of complex two-phase flows in nuclear power plants primary loops. In particular, we performed benchmark numerical simulation of an integral LOCA experiment performed on a test facility modeling the primary circuit of VVER-1000. In addition, we have also analyzed the flow patterns in the VVER-1000 steam generator vessel for stationary and transient operation regimes. For both of these experiments we have compared the numerical results with measured data. Finally, we demonstrate the capabilities of BAGIRA by modeling a hypothetical severe accident for a VVER-1000 type nuclear reactor. The numerical analysis, which modeled all stages of the hypothetical severe accident up to the complete ablation of the reactor cavity bottom, shows the importance of multi-dimensional flow effects.

  16. Enabling functional neural circuit simulations with distributed computing of neuromodulated plasticity.

    PubMed

    Potjans, Wiebke; Morrison, Abigail; Diesmann, Markus

    2010-01-01

    A major puzzle in the field of computational neuroscience is how to relate system-level learning in higher organisms to synaptic plasticity. Recently, plasticity rules depending not only on pre- and post-synaptic activity but also on a third, non-local neuromodulatory signal have emerged as key candidates to bridge the gap between the macroscopic and the microscopic level of learning. Crucial insights into this topic are expected to be gained from simulations of neural systems, as these allow the simultaneous study of the multiple spatial and temporal scales that are involved in the problem. In particular, synaptic plasticity can be studied during the whole learning process, i.e., on a time scale of minutes to hours and across multiple brain areas. Implementing neuromodulated plasticity in large-scale network simulations where the neuromodulatory signal is dynamically generated by the network itself is challenging, because the network structure is commonly defined purely by the connectivity graph without explicit reference to the embedding of the nodes in physical space. Furthermore, the simulation of networks with realistic connectivity entails the use of distributed computing. A neuromodulated synapse must therefore be informed in an efficient way about the neuromodulatory signal, which is typically generated by a population of neurons located on different machines than either the pre- or post-synaptic neuron. Here, we develop a general framework to solve the problem of implementing neuromodulated plasticity in a time-driven distributed simulation, without reference to a particular implementation language, neuromodulator, or neuromodulated plasticity mechanism. We implement our framework in the simulator NEST and demonstrate excellent scaling up to 1024 processors for simulations of a recurrent network incorporating neuromodulated spike-timing dependent plasticity.

  17. A Power Hardware-in-the-Loop Platform with Remote Distribution Circuit Cosimulation

    SciTech Connect

    Palmintier, Bryan; Lundstrom, Blake; Chakraborty, Sudipta; Williams, Tess L.; Schneider, Kevin P.; Chassin, David P.

    2015-04-01

    This paper demonstrates the use of a novel cosimulation architecture that integrates hardware testing using Power Hardware-in-the-Loop (PHIL) with larger-scale electric grid models using off-the-shelf, non-PHIL software tools. This architecture enables utilities to study the impacts of emerging energy technologies on their system and manufacturers to explore the interactions of new devices with existing and emerging devices on the power system, both without the need to convert existing grid models to a new platform or to conduct in-field trials. The paper describes an implementation of this architecture for testing two residential-scale advanced solar inverters at separate points of common coupling. The same hardware setup is tested with two different distribution feeders (IEEE 123 and 8500 node test systems) modeled using GridLAB-D. In addition to simplifying testing with multiple feeders, the architecture demonstrates additional flexibility with hardware testing in one location linked via the Internet to software modeling in a remote location. In testing, inverter current, real and reactive power, and PCC voltage are well captured by the co-simulation platform. Testing of the inverter advanced control features is currently somewhat limited by the software model time step (1 sec) and tested communication latency (24 msec). Overshoot induced oscillations are observed with volt/VAR control delays of 0 and 1.5 sec, while 3.4 sec and 5.5 sec delays produced little or no oscillation. These limitations could be overcome using faster modeling and communication within the same co-simulation architecture.

  18. Distributions of pigments and primary production in a Gulf Stream meander

    SciTech Connect

    Lohrenz, S.E.; Cullen, J.J.; Phinney, D.A.; Olson, D.B.; Yentsch, C.S.

    1993-08-15

    An investigation was made of physical effects of Gulf Stream meandering on the vertical and horizontal distributions of photosynthetic pigments and primary production. Cruises were conducted in the vicinity of a meander east of 73{degrees}W and north of 37{degrees}N from September 21 to October 5 (leg 1) and October 12-21, 1988 (leg 2), on the R/V Cape Hatteras. Relationships of photosynthesis (normalized to chlorophyll) to irradiance (P-I) did not show large horizontal variation, and water column composite P-I curves from leg 1 and leg 2 were similar. Therefore, a single P-I curve derived from pooled data was used to model distributions of primary production. Distributions of photosynthetic pigments were characterized on the basis of in vivo fluorescence profiles and empirical relationships with extracted pigment concentrations. Subsurface irradiance was described using a spectral irradiance model. Cross sections of the Gulf Stream revealed consistently higher pigment concentrations and primary production on the slope water side. Along-stream variations in pigment distributions and primary production were apparently related to density structure influenced by meander circulation. Such variations were less pronounced during leg 2, which came after a transition from a well-defined meander interacting with a warm-core ring (leg 1) to a more linear stream (leg 2). Higher water-column-integrated primary production during leg 2 was attributed to mixing-induced nutrient injection and redistribution of chlorophyll in the photic zone. 47 refs., 13 figs., 2 tabs.

  19. Modeling Distributed Leadership and Management Effectiveness: Primary School Senior Management Teams in England and Wales.

    ERIC Educational Resources Information Center

    Wallace, Mike

    2002-01-01

    Discusses the significance of distributed leadership and management effectiveness; provides background for primary-school senior management teams research; reports headmasters' criteria for judging the effectiveness of senior management teams; reports findings from case studies of four senior management teams; discusses an inductively derived…

  20. Distribution of Primary School Enrollments in Eastern Africa. World Bank Staff Working Papers Number 511.

    ERIC Educational Resources Information Center

    Maas, Jacob van Lutsenburg; Criel, Geert

    Distribution of primary school enrollments within and among 15 countries of the Eastern African region was examined by drawing exclusively on routine annual statistics and by emphasizing simple computer-generated indicators. In its first phase, the study made inter-country comparisons that indicated which countries and which areas in the region…

  1. Measuring circuit

    DOEpatents

    Sun, Shan C.; Chaprnka, Anthony G.

    1977-01-11

    An automatic gain control circuit functions to adjust the magnitude of an input signal supplied to a measuring circuit to a level within the dynamic range of the measuring circuit while a log-ratio circuit adjusts the magnitude of the output signal from the measuring circuit to the level of the input signal and optimizes the signal-to-noise ratio performance of the measuring circuit.

  2. Driver circuit

    NASA Technical Reports Server (NTRS)

    Matsumoto, Raymond T. (Inventor); Higashi, Stanley T. (Inventor)

    1976-01-01

    A driver circuit which has low power requirements, a relatively small number of components and provides flexibility in output voltage setting. The driver circuit comprises, essentially, two portions which are selectively activated by the application of input signals. The output signal is determined by which of the two circuit portions is activated. While each of the two circuit portions operates in a manner similar to silicon controlled rectifiers (SCR), the circuit portions are on only when an input signal is supplied thereto.

  3. 46 CFR 28.365 - Overcurrent protection and switched circuits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... carrying capacity by a circuit breaker or fuse at the connection to the switchboard or distribution panel... circuits must be separate, switched circuits having fused disconnect switches or circuit breakers so...

  4. Estimation of primary productivity in Banda Sea using the vertical distribution model

    NASA Astrophysics Data System (ADS)

    Kemili, Putri; Putri, Mutiara R.

    2014-03-01

    To estimate Net Primary Productivity (NPP) which more represent nature condition, it is important to know both horizontal and vertical distribution. Carbon-based Productivity Model (CbPM) used to calculate NPP in 15 layers of depth. Gauss equation and Lambert Beer Law used to estimate chlorophyll-a and light intensity in each layer from satellite-derived data, whereas the temperature data obtained from model result of HAMburg Shelf Ocean Model (HAMSOM). This model is being applied to verified and describe how the NPP had been distributed in Banda Sea on 2006. Verification results show that CbPM algorithm has clearly give less error in data observation than what Vertically Generalized Production Model (VGPM) algorithm did, which stand on the error average approximately 33%. The results also show that the vertical distribution of NPP in Banda Sea indicate a seasonal variation.

  5. Distributed Hierarchical Control of Multi-Area Power Systems with Improved Primary Frequency Regulation

    SciTech Connect

    Lian, Jianming; Marinovici, Laurentiu D.; Kalsi, Karanjit; Du, Pengwei; Elizondo, Marcelo A.

    2012-12-12

    The conventional distributed hierarchical control architecture for multi-area power systems is revisited. In this paper, a new distributed hierarchical control architecture is proposed. In the proposed architecture, pilot generators are selected in each area to be equipped with decentralized robust control as a supplementary to the conventional droop speed control. With the improved primary frequency control, the system frequency can be restored to the nominal value without the help of secondary frequency control, which reduces the burden of the automatic generation control for frequency restoration. Moreover, the low frequency inter-area electromechanical oscillations can also be effectively damped. The effectiveness of the proposed distributed hierarchical control architecture is validated through detailed simulations.

  6. Illumination distribution and signal transmission for indoor visible light communication with different light-emitting diode arrays and pre-equality circuits

    NASA Astrophysics Data System (ADS)

    Chen, Hsi-Chao; Liou, Cheng-Jyun; Siao, Syuan-Ruei

    2015-11-01

    The purpose of this study was to seek the optimal design for light-emitting diode (LED) arrays and pre-equality circuits in indoor visible lighting illumination combined with communication. The optical and communicational properties of illumination distribution and signal transmission were investigated. These illumination distributions of array sources were derivate and simulated and actually can be used in free-space communication. Simulated results show the total flux size was rectangle>radial>circlearray, and real measurements also showed the total flux was rectangle>radial>circlearray. The simulated and measured results have a similarity of over 98% by normalized cross correlation. In addition, when the distance of the installed lamp from the wall was 1 m, the rectangular array had the best illumination uniformity of 77.24%, and the size of uniformity was the rectangle>radial≈circle array. Finally, the gain and constant-current pre-equality circuits were used in free-space communication with a carrier frequency from 1 KHz to 1 MHz at a distance of 1.8 m. Both the received signal intensity and divergence angle were rectangle>radial>circle array. The constant-current pre-equality circuit could add the divergence angle from ±18.6 deg to ±36.68 deg in the rectangle array at a carrier frequency of 1 MHz.

  7. Visualizing Metal Content and Intracellular Distribution in Primary Hippocampal Neurons with Synchrotron X-Ray Fluorescence

    PubMed Central

    2016-01-01

    Increasing evidence suggests that metal dyshomeostasis plays an important role in human neurodegenerative diseases. Although distinctive metal distributions are described for mature hippocampus and cortex, much less is known about metal levels and intracellular distribution in individual hippocampal neuronal somata. To solve this problem, we conducted quantitative metal analyses utilizing synchrotron radiation X-Ray fluorescence on frozen hydrated primary cultured neurons derived from rat embryonic cortex (CTX) and two regions of the hippocampus: dentate gyrus (DG) and CA1. Comparing average metal contents showed that the most abundant metals were calcium, iron, and zinc, whereas metals such as copper and manganese were less than 10% of zinc. Average metal contents were generally similar when compared across neurons cultured from CTX, DG, and CA1, except for manganese that was larger in CA1. However, each metal showed a characteristic spatial distribution in individual neuronal somata. Zinc was uniformly distributed throughout the cytosol, with no evidence for the existence of previously identified zinc-enriched organelles, zincosomes. Calcium showed a peri-nuclear distribution consistent with accumulation in endoplasmic reticulum and/or mitochondria. Iron showed 2–3 distinct highly concentrated puncta only in peri-nuclear locations. Notwithstanding the small sample size, these analyses demonstrate that primary cultured neurons show characteristic metal signatures. The iron puncta probably represent iron-accumulating organelles, siderosomes. Thus, the metal distributions observed in mature brain structures are likely the result of both intrinsic neuronal factors that control cellular metal content and extrinsic factors related to the synaptic organization, function, and contacts formed and maintained in each region. PMID:27434052

  8. Visualizing Metal Content and Intracellular Distribution in Primary Hippocampal Neurons with Synchrotron X-Ray Fluorescence.

    PubMed

    Colvin, Robert A; Jin, Qiaoling; Lai, Barry; Kiedrowski, Lech

    2016-01-01

    Increasing evidence suggests that metal dyshomeostasis plays an important role in human neurodegenerative diseases. Although distinctive metal distributions are described for mature hippocampus and cortex, much less is known about metal levels and intracellular distribution in individual hippocampal neuronal somata. To solve this problem, we conducted quantitative metal analyses utilizing synchrotron radiation X-Ray fluorescence on frozen hydrated primary cultured neurons derived from rat embryonic cortex (CTX) and two regions of the hippocampus: dentate gyrus (DG) and CA1. Comparing average metal contents showed that the most abundant metals were calcium, iron, and zinc, whereas metals such as copper and manganese were less than 10% of zinc. Average metal contents were generally similar when compared across neurons cultured from CTX, DG, and CA1, except for manganese that was larger in CA1. However, each metal showed a characteristic spatial distribution in individual neuronal somata. Zinc was uniformly distributed throughout the cytosol, with no evidence for the existence of previously identified zinc-enriched organelles, zincosomes. Calcium showed a peri-nuclear distribution consistent with accumulation in endoplasmic reticulum and/or mitochondria. Iron showed 2-3 distinct highly concentrated puncta only in peri-nuclear locations. Notwithstanding the small sample size, these analyses demonstrate that primary cultured neurons show characteristic metal signatures. The iron puncta probably represent iron-accumulating organelles, siderosomes. Thus, the metal distributions observed in mature brain structures are likely the result of both intrinsic neuronal factors that control cellular metal content and extrinsic factors related to the synaptic organization, function, and contacts formed and maintained in each region. PMID:27434052

  9. Printed circuit board industry.

    PubMed

    LaDou, Joseph

    2006-05-01

    The printed circuit board is the platform upon which microelectronic components such as semiconductor chips and capacitors are mounted. It provides the electrical interconnections between components and is found in virtually all electronics products. Once considered low technology, the printed circuit board is evolving into a high-technology product. Printed circuit board manufacturing is highly complicated, requiring large equipment investments and over 50 process steps. Many of the high-speed, miniaturized printed circuit boards are now manufactured in cleanrooms with the same health and safety problems posed by other microelectronics manufacturing. Asia produces three-fourths of the world's printed circuit boards. In Asian countries, glycol ethers are the major solvents used in the printed circuit board industry. Large quantities of hazardous chemicals such as formaldehyde, dimethylformamide, and lead are used by the printed circuit board industry. For decades, chemically intensive and often sloppy manufacturing processes exposed tens of thousands of workers to a large number of chemicals that are now known to be reproductive toxicants and carcinogens. The printed circuit board industry has exposed workers to high doses of toxic metals, solvents, acids, and photolithographic chemicals. Only recently has there been any serious effort to diminish the quantity of lead distributed worldwide by the printed circuit board industry. Billions of electronics products have been discarded in every region of the world. This paper summarizes recent regulatory and enforcement efforts. PMID:16580876

  10. 30 CFR 75.800 - High-voltage circuits; circuit breakers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-voltage circuits; circuit breakers. 75.800... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Underground High-Voltage Distribution § 75.800 High-voltage circuits; circuit breakers. High-voltage circuits entering the underground...

  11. 30 CFR 77.800 - High-voltage circuits; circuit breakers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-voltage circuits; circuit breakers. 77.800... COAL MINES Surface High-Voltage Distribution § 77.800 High-voltage circuits; circuit breakers. High-voltage circuits supplying power to portable or mobile equipment shall be protected by suitable...

  12. 30 CFR 77.800 - High-voltage circuits; circuit breakers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false High-voltage circuits; circuit breakers. 77.800... COAL MINES Surface High-Voltage Distribution § 77.800 High-voltage circuits; circuit breakers. High-voltage circuits supplying power to portable or mobile equipment shall be protected by suitable...

  13. 30 CFR 77.800 - High-voltage circuits; circuit breakers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false High-voltage circuits; circuit breakers. 77.800... COAL MINES Surface High-Voltage Distribution § 77.800 High-voltage circuits; circuit breakers. High-voltage circuits supplying power to portable or mobile equipment shall be protected by suitable...

  14. 30 CFR 77.800 - High-voltage circuits; circuit breakers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false High-voltage circuits; circuit breakers. 77.800... COAL MINES Surface High-Voltage Distribution § 77.800 High-voltage circuits; circuit breakers. High... devices to provide protection against under voltage, grounded phase, short circuit and overcurrent....

  15. 30 CFR 75.800 - High-voltage circuits; circuit breakers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false High-voltage circuits; circuit breakers. 75.800... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Underground High-Voltage Distribution § 75.800 High-voltage circuits; circuit breakers. High-voltage circuits entering the underground...

  16. 30 CFR 77.800 - High-voltage circuits; circuit breakers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false High-voltage circuits; circuit breakers. 77.800... COAL MINES Surface High-Voltage Distribution § 77.800 High-voltage circuits; circuit breakers. High-voltage circuits supplying power to portable or mobile equipment shall be protected by suitable...

  17. Distribution and effects of the muscarinic receptor subtypes in the primary visual cortex

    PubMed Central

    Groleau, Marianne; Kang, Jun Il; Huppé-Gourgues, Frédéric; Vaucher, Elvire

    2015-01-01

    Muscarinic cholinergic receptors modulate the activity and plasticity of the visual cortex. Muscarinic receptors are divided into five subtypes that are not homogeneously distributed throughout the cortical layers and cells types. This distribution results in complex action of the muscarinic receptors in the integration of visual stimuli. Selective activation of the different subtypes can either strengthen or weaken cortical connectivity (e.g., thalamocortical vs. corticocortical), i.e., it can influence the processing of certain stimuli over others. Moreover, muscarinic receptors differentially modulate some functional properties of neurons during experience-dependent activity and cognitive processes and they contribute to the fine-tuning of visual processing. These functions are involved in the mechanisms of attention, maturation and learning in the visual cortex. This minireview describes the anatomo-functional aspects of muscarinic modulation of the primary visual cortex’s (V1) microcircuitry. PMID:26150786

  18. ADDER CIRCUIT

    DOEpatents

    Jacobsohn, D.H.; Merrill, L.C.

    1959-01-20

    An improved parallel addition unit is described which is especially adapted for use in electronic digital computers and characterized by propagation of the carry signal through each of a plurality of denominationally ordered stages within a minimum time interval. In its broadest aspects, the invention incorporates a fast multistage parallel digital adder including a plurality of adder circuits, carry-propagation circuit means in all but the most significant digit stage, means for conditioning each carry-propagation circuit during the time period in which information is placed into the adder circuits, and means coupling carry-generation portions of thc adder circuit to the carry propagating means.

  19. Distribution and controlling mechanisms of primary production on the Louisiana Texas continental shelf

    NASA Astrophysics Data System (ADS)

    Chen, X.; Lohrenz, S. E.; Wiesenburg, D. A.

    2000-06-01

    The northwest (NW) Gulf of Mexico is marked by strong seasonal patterns in regional and mesoscale circulation and variable effects of riverine/estuarine discharge, which influence distributions of nutrients, phytoplankton biomass and primary production. During a series of five cruises in the NW Gulf of Mexico in 1993 and 1994, an extensive data set was collected including nutrients, phytoplankton biomass (chlorophyll a), and photosynthesis-irradiance ( P- E) parameters. Primary production was estimated using P- E parameters in conjunction with profiles of biomass and irradiance. Relatively high biomass and primary production were observed in inner shelf waters during spring conditions of high river discharge. This was attributed to the retention of biomass and nutrients on the shelf by the combination of high river outflow and a westward flow along the inner shelf with consequent onshore Ekman component. During summer, when surface currents shifted towards the north and east, values of nutrients, biomass and primary production were relatively high east of Galveston Bay and decreased outward from the coast. This pattern was apparently a consequence of nutrient inputs from riverine, upwelling and benthic sources. Nutrients, biomass and productivity in the western portion of the study area in summer were generally lower as a result of the upcoast flow of oligotrophic offshore water. Inter-annual variability was observed between November 1993 and 1994 with higher biomass and productivity occurring in November 1993. This was partially attributed to higher river discharge prior to November 1993, retention of biomass and nutrients by the downcoast flow along the inner shelf, and possibly, injection of nutrients onto the shelf at the shelf break. Our findings demonstrate that the interaction of circulation and availability of light and nutrients are largely responsible for variations in primary production. Nitrogen appeared to be the primary limiting nutrient, however, a

  20. Distribution of Ca, Fe, Cu and Zn in primary colorectal cancer and secondary colorectal liver metastases

    NASA Astrophysics Data System (ADS)

    Al-Ebraheem, A.; Mersov, A.; Gurusamy, K.; Farquharson, M. J.

    2010-07-01

    A microbeam synchrotron X-ray fluorescence (μSRXRF) technique has been used to determine the localization and the relative concentrations of Zn, Cu, Fe and Ca in primary colorectal cancer and secondary colorectal liver metastases. 24 colon and 23 liver samples were examined, all of which were formalin fixed tissues arranged as microarrays of 1.0 mm diameter and 10 μm thickness. The distribution of these metals was compared with light transmission images of adjacent sections that were H and E stained to reveal the location of the cancer cells. Histological details were provided for each sample which enable concentrations of all elements in different tissue types to be compared. In the case of liver, significant differences have been found for all elements when comparing tumour, normal, necrotic, fibrotic, and blood vessel tissues (Kruskal Wallis Test, P<0.0001). The concentrations of all elements have also been found to be significantly different among tumour, necrotic, fibrotic, and mucin tissues in the colon samples (Kruskal Wallis Test, P<0.0001). The concentrations of all elements have been compared between primary colorectal samples and colorectal liver metastases. Concentration of Zn, Cu, Fe and Ca are higher in all types of liver tissues compared to those in the colon tissues. Comparing liver tumour and colon tumour samples, significant differences have been found for all elements (Mann Whitney, P<0.0001). For necrotic tissues, significant increase has been found for Zn, Ca, Cu and Fe (Mann Whitney, P<0.0001 for Fe and Zn, 0.014 for Ca, and 0.001 for Cu). The liver fibrotic levels of Zn, Ca, Cu and Fe were higher than the fibrotic colon areas (independent T test, P=0.007 for Zn and Mann Whitney test P<0.0001 for Cu, Fe and Ca). For the blood vessel tissue, the analysis revealed that the difference was only significant for Fe ( P=0.009) from independent T test.

  1. Distribution of phlebotomine sand flies (Diptera: Psychodidae) in a primary forest-crop interface, Salta, Argentina.

    PubMed

    Quintana, M G; Salomón, O D; De Grosso, M S Lizarralde

    2010-11-01

    Disordered urbanization and deforestation are the main activities proposed as causal factors of re-emergence of American cutaneous leishmaniasis caused by Leishmania braziliensis. The purpose of this work was to investigate, in the hyperendemic area of Argentina, the distribution of Phlebotomine sand flies at the modified primary vegetation-crop interface, as one of the potential sites where the effects of changing landscape on sand fly populations may be manifested. Twenty samplings were made between June 2004 and August 2005. The traps to catch sand flies were set on two consecutive nights every month (except in 5 mo, where it became every 15 d). The relationship between sand fly abundance and meteorological and landscape variables was analyzed using non-metric multidimensional scaling and Kendall's correlation coefficients. Lutzomyia neivai (Pinto) was the most abundant species, followed by Lutzomyia migonei (França), Lutzomyia cortelezzii (Brèthes), Lutzomyia shannoni (Dyar), and Lutzomyia punctigeniculata (Floch and Abonnenc). Traps located close to modified areas collected the greatest numbers of sand flies, whereas traps located in the least modified area (adjacent to the primary vegetation) collected the fewest. There was a strong negative correlation between the abundance of sand flies and precipitation. This study shows that even small modifications in the landscape led to an increase in sand fly abundance, mainly Lu. neivai, a Leishmania braziliensis vector. This underscores the need for recommendations about the risk of American cutaneous leishmaniasis before any environmental intervention is done in an endemic area, as well as for the monitoring of sand fly population dynamics at the site of intervention, before, during, and after the process.

  2. Epithelial to Stromal Re-Distribution of Primary Cilia during Pancreatic Carcinogenesis

    PubMed Central

    Schimmack, Simon; Kneller, Sarah; Dadabaeva, Nigora; Bergmann, Frank; Taylor, Andrew; Hackert, Thilo; Werner, Jens; Strobel, Oliver

    2016-01-01

    Background The Hedgehog (HH) pathway is a mediator in pancreatic ductal adenocarcinoma (PDAC). Surprisingly, previous studies suggested that primary cilia (PC), the essential organelles for HH signal transduction, were lost in PDAC. The aim of this study was to determine the presence of PC in human normal pancreas, chronic pancreatitis, and during carcinogenesis to PDAC with focus on both epithelia and stroma. Methods PC were analyzed in paraffin sections from normal pancreas, chronic pancreatitis, intraductal papillary-mucinous neoplasia, and PDAC, as well as in primary human pancreatic stellate cells (PSC) and pancreatic cancer cell lines by double immunofluorescence staining for acetylated α-tubuline and γ-tubuline. Co-staining for the HH receptors PTCH1, PTCH2 and SMO was also performed. Results PC are gradually lost during pancreatic carcinogenesis in the epithelium: the fraction of cells with PC gradually and significantly decreased from 32% in ducts of normal pancreas, to 21% in ducts of chronic pancreatitis, to 18% in PanIN1a, 6% in PanIN2, 3% in PanIN3 and to 1.2% in invasive PDAC. However, this loss of PC in the neoplastic epithelium is accompanied by a gain of PC in the surrounding stroma. The fraction of stromal cells with PC significantly increased from 13% around normal ducts to about 30% around PanIN and PDAC. HH-receptors were detected in tumor stroma but not in epithelial cells. PC are also present in PSC and pancreatic cancer cell lines. Conclusion PC are not lost during pancreatic carcinogenesis but re-distributed from the epithelium to the stroma. This redistribution may explain the re-direction of HH signaling towards the stroma during pancreatic carcinogenesis. PMID:27783689

  3. GATING CIRCUITS

    DOEpatents

    Merrill, L.C.

    1958-10-14

    Control circuits for vacuum tubes are described, and a binary counter having an improved trigger circuit is reported. The salient feature of the binary counter is the application of the input signal to the cathode of each of two vacuum tubes through separate capacitors and the connection of each cathode to ground through separate diodes. The control of the binary counter is achieved in this manner without special pulse shaping of the input signal. A further advantage of the circuit is the simplicity and minimum nuruber of components required, making its use particularly desirable in computer machines.

  4. MULTIPLIER CIRCUIT

    DOEpatents

    Thomas, R.E.

    1959-01-20

    An electronic circuit is presented for automatically computing the product of two selected variables by multiplying the voltage pulses proportional to the variables. The multiplier circuit has a plurality of parallel resistors of predetermined values connected through separate gate circults between a first input and the output terminal. One voltage pulse is applied to thc flrst input while the second voltage pulse is applied to control circuitry for the respective gate circuits. Thc magnitude of the second voltage pulse selects the resistors upon which the first voltage pulse is imprcssed, whereby the resultant output voltage is proportional to the product of the input voltage pulses

  5. Unequal socioeconomic distribution of the primary care workforce: whole-population small area longitudinal study

    PubMed Central

    Cookson, Richard; Fleetcroft, Robert; Ali, Shehzad

    2016-01-01

    Objective To measure changes in socioeconomic inequality in the distribution of family physicians (general practitioners (GPs)) relative to need in England from 2004/2005 to 2013/2014. Design Whole-population small area longitudinal data linkage study. Setting England from 2004/2005 to 2013/2014. Participants 32 482 lower layer super output areas (neighbourhoods of 1500 people on average). Main outcome measures Slope index of inequality (SII) between the most and least deprived small areas in annual full-time equivalent GPs (FTE GPs) per 100 000 need adjusted population. Results In 2004/2005, inequality in primary care supply as measured by the SII in FTE GPs was 4.2 (95% CI 3.1 to 5.3) GPs per 100 000. By 2013/2014, this SII had fallen to −0.7 (95% CI −2.5 to 1.1) GPs per 100 000. The number of FTE GPs per 100 000 serving the most deprived fifth of small areas increased over this period from 54.0 to 60.5, while increasing from 57.2 to 59.9 in the least deprived fifth, so that by the end of the study period there were more GPs per 100 000 need adjusted population in the most deprived areas than in the least deprived. The increase in GP supply in the most deprived fifth of neighbourhoods was larger in areas that received targeted investment for establishing new practices under the ‘Equitable Access to Primary Medical Care’. Conclusions There was a substantial reduction in socioeconomic inequality in family physician supply associated with national policy. This policy may not have completely eliminated socioeconomic inequality in family physician supply since existing need adjustment formulae do not fully capture the additional burden of multimorbidity in deprived neighbourhoods. The small area approach introduced in this study can be used routinely to monitor socioeconomic inequality of access to primary care and to indicate workforce shortages in particular neighbourhoods. http://creativecommons.org/licenses/by/4.0 PMID:26787245

  6. Distribution of Risk Factors in Male and Female Primary Health Care Patients with Osteoarthritis in Albania

    PubMed Central

    Hoxha, Fatos; Tafaj, Argjent; Roshi, Enver; Burazeri, Genc

    2015-01-01

    Aim: We aimed to describe the distribution of the main risk factors among primary health care users diagnosed with osteoarthritis in Albania, a post-communist country in South Eastern Europe. Methods: Our study involved all individuals who were diagnosed with osteoarthritis over a two-year period (January 2013 – December 2014) in several primary health care centers in Tirana, the Albanian capital. On the whole, during this two-year period, 1179 adult individuals were diagnosed with osteoarthritis (521 men aged 60.1±10.6 years and 658 women aged 58.1±9.6 years). According to the criteria of the American College of Rheumatology, the diagnosis of osteoarthritis was based on the history of the disease, physical examination, laboratory findings and radiological findings. Binary logistic regression was used to assess the sex-differences regarding the major risk factors among individuals diagnosed with osteoarthritis. Results: In multivariable-adjusted logistic regression models, female gender was inversely associated with smoking (OR=0.39, 95%CI=0.27-0.56), alcohol intake (OR=0.08, 95%CI=0.06-0.10), overweight but not obesity (OR=0.65, 95%CI=0.46-0.91 and OR=0.74, 95%CI=0.46-1.18, respectively), weight lifting (OR=0.38, 95%CI=0.22-0.66) and heavy physical exercise (OR=0.69, 95%CI=0.46-1.03). Conversely, female gender was positively related to genetic factors (OR=2.17, 95%CI=1.55-3.04) and preexisting inflammatory diseases (OR=1.53, 95%CI=0.93-2.53). Conclusion: This study offers useful evidence about the distribution of the main risk factors for osteoarthritis in adult individuals diagnosed with osteoarthritis in Albania. This information may support health professionals and decision-makers in Albania for evidence-based health planning and policy formulation in order to control the toll of osteoarthritis in this transitional society. PMID:26261379

  7. Phenology of particle size distributions and primary productivity in the North Pacific subtropical gyre (Station ALOHA)

    NASA Astrophysics Data System (ADS)

    White, Angelicque E.; Letelier, Ricardo M.; Whitmire, Amanda L.; Barone, Benedetto; Bidigare, Robert R.; Church, Matthew J.; Karl, David M.

    2015-11-01

    The particle size distribution (PSD) is a critical aspect of the oceanic ecosystem. Local variability in the PSD can be indicative of shifts in microbial community structure and reveal patterns in cell growth and loss. The PSD also plays a central role in particle export by influencing settling speed. Satellite-based models of primary productivity (PP) often rely on aspects of photophysiology that are directly related to community size structure. In an effort to better understand how variability in particle size relates to PP in an oligotrophic ecosystem, we collected laser diffraction-based depth profiles of the PSD and pigment-based classifications of phytoplankton functional types (PFTs) on an approximately monthly basis at the Hawaii Ocean Time-series Station ALOHA, in the North Pacific subtropical gyre. We found a relatively stable PSD in the upper water column. However, clear seasonality is apparent in the vertical distribution of distinct particle size classes. Neither laser diffraction-based estimations of relative particle size nor pigment-based PFTs was found to be significantly related to the rate of 14C-based PP in the light-saturated upper euphotic zone. This finding indicates that satellite retrievals of particle size, based on particle scattering or ocean color would not improve parameterizations of present-day bio-optical PP models for this region. However, at depths of 100-125 m where irradiance exerts strong control on PP, we do observe a significant linear relationship between PP and the estimated carbon content of 2-20 μm particles.

  8. Estimating net primary production of natural grassland and its spatio-temporal distribution in China.

    PubMed

    Zhang, Meiling; Lal, Rattan; Zhao, Youyi; Jiang, Wenlan; Chen, Quangong

    2016-05-15

    The net primary production (NPP) of grassland largely determines terrestrial carbon (C) sinks, and thus plays an important role in the global C cycle. Comprehensive and sequential classification system of grasslands (CSCS) is a unique vegetation classification system (mainly for grassland) that is dependent on quantitative measurement indices [>0°C annual cumulative temperature (Σθ) and moisture index (K-value)]. Based on the relationship of the quantitative classification of CSCS and grassland NPP, a modified model of Carnegie-Ames-Stanford Approach (CASA) was used to predict the grassland NPP and its temporal and spatial distribution in China from 2004 to 2008. The scatter plot of the estimated NPP and the observed NPP showed that the estimated data can be accepted with correlation coefficient of 0.896 (P<0.05). The average annual NPP of grassland from 2004 to 2008 in China ranged from 443.23 to 554.40 g Cm(-2)yr.(-)(1). The NPP also showed spatial-temporal variations. There existed an increasing trend of NPP from the northwest to southeast due to the zonal distribution of vegetation. From the trend of monthly variations, it can be drawn that the NPP accumulation primarily occurred between April and October. The average NPP over seven months from April to October was 482.19 g Cm(-2), or about 88.78% of the annual total. The spatial-temporal trend suggests the importance of water and thermal regimes in determining the grassland NPP (i.e. water and thermal are key limited factors for the grassland production), which is also confirmed by a cluster analysis. The mean annual NPP and the total annual NPP differed significantly among grassland classes corresponding with different Σθ and K-value. The results demonstrate that the grassland NPP and the classes/super-classes in CSCS achieve the optimum coupling.

  9. Phenology of particle size distributions and primary productivity in the North Pacific subtropical gyre (Station ALOHA)

    PubMed Central

    Letelier, Ricardo M.; Whitmire, Amanda L.; Barone, Benedetto; Bidigare, Robert R.; Church, Matthew J.; Karl, David M.

    2015-01-01

    Abstract The particle size distribution (PSD) is a critical aspect of the oceanic ecosystem. Local variability in the PSD can be indicative of shifts in microbial community structure and reveal patterns in cell growth and loss. The PSD also plays a central role in particle export by influencing settling speed. Satellite‐based models of primary productivity (PP) often rely on aspects of photophysiology that are directly related to community size structure. In an effort to better understand how variability in particle size relates to PP in an oligotrophic ecosystem, we collected laser diffraction‐based depth profiles of the PSD and pigment‐based classifications of phytoplankton functional types (PFTs) on an approximately monthly basis at the Hawaii Ocean Time‐series Station ALOHA, in the North Pacific subtropical gyre. We found a relatively stable PSD in the upper water column. However, clear seasonality is apparent in the vertical distribution of distinct particle size classes. Neither laser diffraction‐based estimations of relative particle size nor pigment‐based PFTs was found to be significantly related to the rate of 14C‐based PP in the light‐saturated upper euphotic zone. This finding indicates that satellite retrievals of particle size, based on particle scattering or ocean color would not improve parameterizations of present‐day bio‐optical PP models for this region. However, at depths of 100–125 m where irradiance exerts strong control on PP, we do observe a significant linear relationship between PP and the estimated carbon content of 2–20 μm particles. PMID:27812434

  10. Measuring the distribution of cellulose microfibril angles in primary cell walls by small angle X-ray scattering

    PubMed Central

    2014-01-01

    Background X-ray scattering is a well-established method for measuring cellulose microfibril angles in secondary cell walls. However, little data is available on the much thinner primary cell walls. Here, we show that microfibril orientation distributions can be determined by small angle X-ray scattering (SAXS) even in primary cell walls. The technique offers a number of advantages: samples can be analyzed in the native hydrated state without any preparation which minimizes the risk of artifacts and allows for fast data acquisition. The method provides data averaged over a specimen region, determined by the size of the used X-ray beam and, thus, yields the microfibril orientation distribution within this region. Results Cellulose microfibril orientation distributions were obtained for single cells of the alga Chara corallina, as well as for the multicellular hypocotyl of Arabidopsis thaliana. In both, Chara and Arabidopsis, distributions with a broad scattering around mean microfibril angles of approximately 0° and 90° towards the longitudinal axis of the cells were found. Conclusions With SAXS, the structure of primary cell walls can be analysed in their native state and new insights into the cellulose microfibril orientation of primary cell walls can be gained. The data shows that SAXS can serve as a valuable tool for the analysis of cellulose microfibril orientation in primary cell walls and, in consequence, add to the understanding of its mechanical behaviour and the intriguing mechanisms behind cell growth. PMID:25170343

  11. Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: a review of lesion distribution and circuit disconnection in cortical visual pathways

    NASA Technical Reports Server (NTRS)

    Hof, P. R.; Vogt, B. A.; Bouras, C.; Morrison, J. H.; Bloom, F. E. (Principal Investigator)

    1997-01-01

    In recent years, the existence of visual variants of Alzheimer's disease characterized by atypical clinical presentation at onset has been increasingly recognized. In many of these cases post-mortem neuropathological assessment revealed that correlations could be established between clinical symptoms and the distribution of neurodegenerative lesions. We have analyzed a series of Alzheimer's disease patients presenting with prominent visual symptomatology as a cardinal sign of the disease. In these cases, a shift in the distribution of pathological lesions was observed such that the primary visual areas and certain visual association areas within the occipito-parieto-temporal junction and posterior cingulate cortex had very high densities of lesions, whereas the prefrontal cortex had fewer lesions than usually observed in Alzheimer's disease. Previous quantitative analyses have demonstrated that in Alzheimer's disease, primary sensory and motor cortical areas are less damaged than the multimodal association areas of the frontal and temporal lobes, as indicated by the laminar and regional distribution patterns of neurofibrillary tangles and senile plaques. The distribution of pathological lesions in the cerebral cortex of Alzheimer's disease cases with visual symptomatology revealed that specific visual association pathways were disrupted, whereas these particular connections are likely to be affected to a less severe degree in the more common form of Alzheimer's disease. These data suggest that in some cases with visual variants of Alzheimer's disease, the neurological symptomatology may be related to the loss of certain components of the cortical visual pathways, as reflected by the particular distribution of the neuropathological markers of the disease.

  12. TRIPPING CIRCUIT

    DOEpatents

    Lees, G.W.; McCormick, E.D.

    1962-05-22

    A tripping circuit employing a magnetic amplifier for tripping a reactor in response to power level, period, or instrument failure is described. A reference winding and signal winding are wound in opposite directions on the core. Current from an ion chamber passes through both windings. If the current increases at too fast a rate, a shunt circuit bypasses one or the windings and the amplifier output reverses polarity. (AEC)

  13. Cell-Type-Specific Cytokinin Distribution within the Arabidopsis Primary Root Apex[OPEN

    PubMed Central

    Antoniadi, Ioanna; Plačková, Lenka; Simonovik, Biljana; Doležal, Karel; Turnbull, Colin; Ljung, Karin; Novák, Ondřej

    2015-01-01

    Cytokinins (CKs) play a crucial role in many physiological and developmental processes at the levels of individual plant components (cells, tissues, and organs) and by coordinating activities across these parts. High-resolution measurements of intracellular CKs in different plant tissues can therefore provide insights into their metabolism and mode of action. Here, we applied fluorescence-activated cell sorting of green fluorescent protein (GFP)-marked cell types, combined with solid-phase microextraction and an ultra-high-sensitivity mass spectrometry (MS) method for analysis of CK biosynthesis and homeostasis at cellular resolution. This method was validated by series of control experiments, establishing that protoplast isolation and cell sorting procedures did not greatly alter endogenous CK levels. The MS-based method facilitated the quantification of all the well known CK isoprenoid metabolites in four different transgenic Arabidopsis thaliana lines expressing GFP in specific cell populations within the primary root apex. Our results revealed the presence of a CK gradient within the Arabidopsis root tip, with a concentration maximum in the lateral root cap, columella, columella initials, and quiescent center cells. This distribution, when compared with previously published auxin gradients, implies that the well known antagonistic interactions between the two hormone groups are cell type specific. PMID:26152699

  14. Pattern and distribution of ocular morbidity in primary school children of rural Delhi.

    PubMed

    Chaturvedi, S; Aggarwal, O P

    1999-01-01

    A total of 679 primary school children drawn from developed southern parts and underdeveloped eastern parts of Delhi were examined for ocular morbidity. Their age range was 5-15 years and both sexes had almost equal representation. The prevalence of eye diseases was relatively high. Over 40 percent of all the children studied had one or more ocular problems. Trachoma (18%) was the most common ocular morbidity followed by vitamin A deficiency (10.6%), visual acuity < 6/9 (7.4%) and apparent/latent squint (7.4%). In most of these eye disorders, the majority of the children came from the underdeveloped eastern parts of Delhi. Ocular morbidity seems to be unevenly distributed in rural Delhi with a significantly worse picture in the underdeveloped eastern parts, across the river 'Yamuna'. Though blinding trachoma may cease to be a major problem in India, the country continues to have endemic pockets of its non-blinding form. One puzzling observation was that children with protein-energy malnutrition (PEM) did not show any specific vulnerability to ocular diseases. In fact, those with normal weight-height index were having a higher share of eye diseases. Though this issue needs to be explored further in the light of biological plausibility, it appears that children who do not have PEM are also exposed to ocular diseases at least with comparable risk. PMID:10829825

  15. Myosin-Va Mediates RNA Distribution in Primary Fibroblasts From Multiple Organs

    PubMed Central

    Salerno, Verônica P.; Calliari, Aldo; William Provance, D.; Sotelo-Silveira, José R.; Sotelo, José R.; Mercer, John A.

    2008-01-01

    Myosin-Va has been shown to have multiple functions in a variety of cell types, including a role in RNA transport in neurons. Using primary cultures of cells from organs of young dilute-lethal (Myo5ad-l/Myo5ad-l) null mutant mice and wild-type controls, we show that in some, but not all, tissues, RNA distribution is dramatically different in the homozygous null mutant cells. The dependence of RNA localization on myosin-Va correlates with the relative abundance of the brain-specific splicing pattern of the myosin-Va tail. We also show that myosin-Va is involved in RNA localization soon after synthesis, because the effects of its absence are diminished for RNAs that are more than 30 min old. Finally, we show that localization of β-actin mRNA is significantly changed by the absence of myosin-Va. These results suggest that myosin-Va is involved in a transient transport or tethering function in the perinuclear region. Cell Motil. PMID:18357619

  16. Global Intraurban Intake Fractions for Primary Air Pollutants from Vehicles and Other Distributed Sources

    PubMed Central

    2012-01-01

    We model intraurban intake fraction (iF) values for distributed ground-level emissions in all 3646 global cities with more than 100 000 inhabitants, encompassing a total population of 2.0 billion. For conserved primary pollutants, population-weighted median, mean, and interquartile range iF values are 26, 39, and 14–52 ppm, respectively, where 1 ppm signifies 1 g inhaled/t emitted. The global mean urban iF reported here is roughly twice as large as previous estimates for cities in the United States and Europe. Intake fractions vary among cities owing to differences in population size, population density, and meteorology. Sorting by size, population-weighted mean iF values are 65, 35, and 15 ppm, respectively, for cities with populations larger than 3, 0.6–3, and 0.1–0.6 million. The 20 worldwide megacities (each >10 million people) have a population-weighted mean iF of 83 ppm. Mean intraurban iF values are greatest in Asia and lowest in land-rich high-income regions. Country-average iF values vary by a factor of 3 among the 10 nations with the largest urban populations. PMID:22332712

  17. Modeling and spatially distributing forest net primary production at the regional scale.

    PubMed

    Mickler, Robert A; Earnhardt, Todd S; Moore, Jennifer A

    2002-04-01

    Forest, agricultural, rangeland, wetland, and urban landscapes have different rates of carbon sequestration and total carbon sequestration potential under alternative management options. Changes in the proportion and spatial distribution of land use could enhance or degrade that area's ability to sequester carbon in terrestrial ecosystems. As the ecosystems within a landscape change due to natural or anthropogenic processes, they may go from being a carbon sink to a carbon source or vice versa. Satellite image analysis has been tested for timely and accurate measurement of spatially explicit land use change and is well suited for use in inventory and monitoring of terrestrial carbon. The coupling of Landsat Thematic Mapper (TM) data with a physiologically based forest productivity model (PnET-II) and historic climatic data provides an opportunity to enhance field plot-based forest inventory and monitoring methodologies. We use periodic forest inventory data from the U.S. Department of Agriculture (USDA) Forest Service's Forest Inventory and Analysis (FIA) Program to obtain estimates of forest area and type and to generate estimates of carbon storage for evergreen, deciduous, and mixed-forest classes. The area information is used in an accuracy assessment of remotely sensed forest cover at the regional scale. The map display of modeled net primary production (NPP) shows a range of forest carbon storage potentials and their spatial relationship to other landscape features across the southern United States. This methodology addresses the potential for measuring and projecting forest carbon sequestration in the terrestrial biosphere of the southern United States.

  18. Pattern and distribution of ocular morbidity in primary school children of rural Delhi.

    PubMed

    Chaturvedi, S; Aggarwal, O P

    1999-01-01

    A total of 679 primary school children drawn from developed southern parts and underdeveloped eastern parts of Delhi were examined for ocular morbidity. Their age range was 5-15 years and both sexes had almost equal representation. The prevalence of eye diseases was relatively high. Over 40 percent of all the children studied had one or more ocular problems. Trachoma (18%) was the most common ocular morbidity followed by vitamin A deficiency (10.6%), visual acuity < 6/9 (7.4%) and apparent/latent squint (7.4%). In most of these eye disorders, the majority of the children came from the underdeveloped eastern parts of Delhi. Ocular morbidity seems to be unevenly distributed in rural Delhi with a significantly worse picture in the underdeveloped eastern parts, across the river 'Yamuna'. Though blinding trachoma may cease to be a major problem in India, the country continues to have endemic pockets of its non-blinding form. One puzzling observation was that children with protein-energy malnutrition (PEM) did not show any specific vulnerability to ocular diseases. In fact, those with normal weight-height index were having a higher share of eye diseases. Though this issue needs to be explored further in the light of biological plausibility, it appears that children who do not have PEM are also exposed to ocular diseases at least with comparable risk.

  19. The grain-size distribution of pyroclasts: Primary fragmentation, conduit sorting or abrasion?

    NASA Astrophysics Data System (ADS)

    Kueppers, U.; Schauroth, J.; Taddeucci, J.

    2013-12-01

    Explosive volcanic eruptions expel a mixture of pyroclasts and lithics. Pyroclasts, fragments of the juvenile magma, record the state of the magma at fragmentation in terms of porosity and crystallinity. The grain size distribution of pyroclasts is generally considered to be a direct consequence of the conditions at magma fragmentation that is mainly driven by gas overpressure in bubbles, high shear rates, contact with external water or a combination of these factors. Stress exerted by any of these processes will lead to brittle fragmentation by overcoming the magma's relaxation timescale. As a consequence, most pyroclasts exhibit angular shapes. Upon magma fragmentation, the gas pyroclast mixture is accelerated upwards and eventually ejected from the vent. The total grain size distribution deposited is a function of fragmentation conditions and transport related sorting. Porous pyroclasts are very susceptible to abrasion by particle-particle or particle-conduit wall interaction. Accordingly, pyroclastic fall deposits with angular clasts should proof a low particle abrasion upon contact to other surfaces. In an attempt to constrain the degree of particle interaction during conduit flow, monomodal batches of washed pyroclasts have been accelerated upwards by rapid decompression and subsequently investigated for their grain size distribution. In our set-up, we used a vertical cylindrical tube without surface roughness as conduit. We varied grain size (0.125-0.25; 0.5-1; 1-2 mm), porosity (0; 10; 30 %), gas-particle ratio (10 and 40%), conduit length (10 and 28 cm) and conduit diameter (2.5 and 6 cm). All ejected particles were collected after settling at the base of a 3.3 m high tank and sieved at one sieve size below starting size (half-Φ). Grain size reduction showed a positive correlation with starting grain size, porosity and overpressure at the vent. Although milling in a volcanic conduit may take place, porous pyroclasts are very likely to be a primary product

  20. 30 CFR 75.800-1 - Circuit breakers; location.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Underground High-Voltage Distribution § 75.800-1 Circuit breakers; location. Circuit breakers protecting high-voltage circuits entering...

  1. 46 CFR 28.860 - Overcurrent protection and switched circuits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... breaker or fuse at the connection to the switchboard or distribution panel bus. (d) Each circuit breaker... circuits having fused disconnect switches or circuit breakers so that only the appropriate...

  2. 30 CFR 75.800-1 - Circuit breakers; location.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Underground High-Voltage Distribution § 75.800-1 Circuit breakers; location. Circuit breakers protecting high-voltage circuits entering...

  3. The Social Distribution of Primary Social Isolation among the Aged: A Subcultural Approach.

    ERIC Educational Resources Information Center

    Rutzen, S. Robert

    1980-01-01

    Examines subcultural variations in primary social isolation in older persons in Albany. Seven hypothetical subcultures contain enough respondents to be numerically important. Two subcultures have above-average rates of primary social isolation. Three subcultures have below-average rates. Results indicate that primary social isolation is a group…

  4. The Global Circuit.

    ERIC Educational Resources Information Center

    Lansford, Henry

    1983-01-01

    Discusses the nature of and research related to a theory explaining the earth's electric budget. The theory suggests a global electric circuit completed by a positive current flowing up into thunderstorm clouds, from clouds to ionosphere, distributed around the globe, and down to earth through the lower atmosphere in fair-weather regions. (JN)

  5. Integrated-Circuit Pseudorandom-Number Generator

    NASA Technical Reports Server (NTRS)

    Steelman, James E.; Beasley, Jeff; Aragon, Michael; Ramirez, Francisco; Summers, Kenneth L.; Knoebel, Arthur

    1992-01-01

    Integrated circuit produces 8-bit pseudorandom numbers from specified probability distribution, at rate of 10 MHz. Use of Boolean logic, circuit implements pseudorandom-number-generating algorithm. Circuit includes eight 12-bit pseudorandom-number generators, outputs are uniformly distributed. 8-bit pseudorandom numbers satisfying specified nonuniform probability distribution are generated by processing uniformly distributed outputs of eight 12-bit pseudorandom-number generators through "pipeline" of D flip-flops, comparators, and memories implementing conditional probabilities on zeros and ones.

  6. Paying for primary care: a cross-sectional analysis of cost and morbidity distributions across primary care payment models in Ontario Canada.

    PubMed

    Rudoler, David; Laporte, Audrey; Barnsley, Janet; Glazier, Richard H; Deber, Raisa B

    2015-01-01

    Policy-makers desire an optimal balance of financial incentives to improve productivity and encourage improved quality in primary care, while also avoiding issues of risk-selection inherent to capitation-based payment. In this paper we analyze risk-selection in capitation-based payment by using administrative data for patients (n = 11,600,911) who were rostered (i.e., signed an enrollment form, or received a majority of care) with a primary care physician (n = 8621) in Ontario, Canada in 2010/11. We analyze this data using a relative distribution approach and compare distributions of patient costs and morbidity across primary care payment models. Our results suggest a relationship between being in a capitation-based payment scheme and having low cost patients (and presumably healthy patients) compared to fee-for-service physicians. However, we do not have evidence that physicians in capitation-based models are reducing the care they provide to sick and high cost patients. These findings suggest there is a relationship between payment type and risk-selection, particularly for low-cost and healthy patients. PMID:25461858

  7. Distribution of Local Open-Circuit Voltage on Amorphous and Nanocrystalline Mixed-Phase Si:H and SiGe:H Solar Cells: Preprint

    SciTech Connect

    Jiang, C.-S.; Moutinho, H. R.; Al-Jassim, M. M.; Kazmerski, L. L.; Yan, B.; Owens, J. M.; Yang, J.; Guha, S.

    2006-05-01

    Local open-circuit voltage (Voc) distributions on amorphous and nanocrystalline mixed-phase silicon solar cells were measured using a scanning Kelvin probe microscope (SKPM) on the p layer of an n-i-p structure without the top ITO contact. During the measurement, the sample was illuminated with a laser beam that was used for the atomic force microscopy (AFM). Therefore, the surface potential measured by SKPM is the sum of the local Voc and the difference in workfunction between the p layer and the AFM tip. Comparing the SKPM and AFM images, we find that nanocrystallites aggregate in the amorphous matrix with an aggregation size of {approx}0.5 ..mu..m in diameter, where many nanometer-size grains are clustered. The Voc distribution shows valleys in the nanocrystalline aggregation area. The transition from low to high Voc regions is a gradual change within a distance of about 1 ..mu..m. The minimum Voc value in the nanocrystalline clusters in the mixed-phase region is larger than the Voc of a nc-Si:H single-phase solar cell. These results could be due to lateral photo-charge redistribution between the two phases. We have also carried out local Voc measurements on mixed-phase SiGe:H alloy solar cells. The magnitudes of Voc in the amorphous and nanocrystalline regions are consistent with the J-V measurements.

  8. NOx Emission Reduction by the Optimization of the Primary Air Distribution in the 235Mwe CFB Boiler

    NASA Astrophysics Data System (ADS)

    Mirek, P.; Czakiert, T.; Nowak, W.

    The article presents the results of experimental studies conducted on a large-scale 235 MWe CFB (Circulating Fluidized Bed) boiler, in which the primary air distribution system was modified. The modification was connected with the change of internal geometry of primary air channels as well as internal space of plenum chamber. The obtained results have shown, that the optimization of primary air flow has a great influence on the intensity of the combustion process and the temperature distribution along the height of combustion chamber. As a result, the NOx emission has been reduced by up to ten percent and the temperature profile in the combustion chamber has been revealed to be more uniform.

  9. MULTIPLIER CIRCUIT

    DOEpatents

    Chase, R.L.

    1963-05-01

    An electronic fast multiplier circuit utilizing a transistor controlled voltage divider network is presented. The multiplier includes a stepped potentiometer in which solid state or transistor switches are substituted for mechanical wipers in order to obtain electronic switching that is extremely fast as compared to the usual servo-driven mechanical wipers. While this multiplier circuit operates as an approximation and in steps to obtain a voltage that is the product of two input voltages, any desired degree of accuracy can be obtained with the proper number of increments and adjustment of parameters. (AEC)

  10. Low-frequency circuit analysis of MHD-EMP-induced transients on three-phase distribution systems

    SciTech Connect

    Mayhall, D.J.; Yee, J.H.

    1992-07-01

    The magnetohydrodynamic electromagnetic pulse (MHD-EMP) generated by a nuclear explosion in the earth`s ionosphere is believed by a number of researchers to pose a potentially severe threat to long electric utility transmission and distribution systems in the United States. The disturbances caused by MHD-EMP are similar to the electromagnetic transients caused by solar-induced geomagnetic storms, but are generally expected to be more intense with shorter durations. Recent solar-induced storms have caused appreciable damage to electric utility equipment in Canada and the northern United States. In March of 1989, a solar-induced geomagnetic storm caused a blackout of the Hydro-Quebec power system in the province of Quebec, failure of step-up power transformers at the Salem Nuclear Generating Plant of the Public Service Electric and Gas Company, and a number of less severe power disruptions in the United States. Since the amplitudes of MHD-EMP induced transients are expected to be stronger than those produced by solar-induced geomagnetic storms, unprotected electric utility power systems may be quite vulnerable to MHD-EMP.

  11. Low-frequency circuit analysis of MHD-EMP-induced transients on three-phase distribution systems

    SciTech Connect

    Mayhall, D.J.; Yee, J.H.

    1992-07-01

    The magnetohydrodynamic electromagnetic pulse (MHD-EMP) generated by a nuclear explosion in the earth's ionosphere is believed by a number of researchers to pose a potentially severe threat to long electric utility transmission and distribution systems in the United States. The disturbances caused by MHD-EMP are similar to the electromagnetic transients caused by solar-induced geomagnetic storms, but are generally expected to be more intense with shorter durations. Recent solar-induced storms have caused appreciable damage to electric utility equipment in Canada and the northern United States. In March of 1989, a solar-induced geomagnetic storm caused a blackout of the Hydro-Quebec power system in the province of Quebec, failure of step-up power transformers at the Salem Nuclear Generating Plant of the Public Service Electric and Gas Company, and a number of less severe power disruptions in the United States. Since the amplitudes of MHD-EMP induced transients are expected to be stronger than those produced by solar-induced geomagnetic storms, unprotected electric utility power systems may be quite vulnerable to MHD-EMP.

  12. Characterization of primary cilia distribution and morphology during lactation, stasis, and involution in the bovine mammary gland.

    PubMed

    Millier, Melanie J; Singh, Kuljeet; Poole, C Anthony

    2013-12-01

    Primary cilia are small, sensory organelles projecting from virtually all cells and are vital for cellular and tissue function. Their distribution in bovine mammary tissue has not previously been assessed, despite the potential for these organelles to provide specialized perceptive and regulatory functions to this acutely responsive and adaptive gland. The research objectives were to assess ciliary distribution and morphology during active lactation, milk stasis, and early involution using tissue samples obtained following the abrupt cessation of milk removal in nonpregnant, Friesian dairy cows at mid-lactation. Routinely processed tissue sections were obtained at intervals from 6 to 192 hr after the last milking (N = 3 animals per group) and assigned to active lactation (6-12 hr), milk stasis (18-36 hr), and early involution (72-192 hr). Primary cilia were observed in luminal secretory epithelial cells (SECs), myoepithelial cells, and stromal cells following fluorescent immunohistochemistry and confocal microscopy. In SECs, some primary cilia appeared deflected against the apical cell membrane. The proportion of those deflected was greater during milk stasis than active lactation. Data show that primary cilia were suitably placed in three important cell types to potentially coordinate various forms of signal transduction relying on both mechanosensation and chemosensation, according to the physical and physiological state of the gland. Their cell-type distribution and morphology provide new directions in the study of mammary regulation to enhance the understanding of how various mammary-specific cellular responses may be initiated by biochemical or local biophysical factors. PMID:24155176

  13. Circuit Training.

    ERIC Educational Resources Information Center

    Nelson, Jane B.

    1998-01-01

    Describes a research-based activity for high school physics students in which they build an LC circuit and find its resonant frequency of oscillation using an oscilloscope. Includes a diagram of the apparatus and an explanation of the procedures. (DDR)

  14. Twin Neurons for Efficient Real-World Data Distribution in Networks of Neural Cliques: Applications in Power Management in Electronic Circuits.

    PubMed

    Boguslawski, Bartosz; Gripon, Vincent; Seguin, Fabrice; Heitzmann, Frédéric

    2016-02-01

    Associative memories are data structures that allow retrieval of previously stored messages given part of their content. They, thus, behave similarly to the human brain's memory that is capable, for instance, of retrieving the end of a song, given its beginning. Among different families of associative memories, sparse ones are known to provide the best efficiency (ratio of the number of bits stored to that of the bits used). Recently, a new family of sparse associative memories achieving almost optimal efficiency has been proposed. Their structure, relying on binary connections and neurons, induces a direct mapping between input messages and stored patterns. Nevertheless, it is well known that nonuniformity of the stored messages can lead to a dramatic decrease in performance. In this paper, we show the impact of nonuniformity on the performance of this recent model, and we exploit the structure of the model to improve its performance in practical applications, where data are not necessarily uniform. In order to approach the performance of networks with uniformly distributed messages presented in theoretical studies, twin neurons are introduced. To assess the adapted model, twin neurons are used with the real-world data to optimize power consumption of electronic circuits in practical test cases.

  15. Investigating the Cherenkov light lateral distribution function for primary proton and iron nuclei in extensive air showers

    NASA Astrophysics Data System (ADS)

    Al-Rubaiee, A. A.; Hashim, U.; Al-Douri, Y.

    2015-11-01

    The lateral distribution function (LDF) of Cherenkov radiation in extensive air showers (EAS) was simulated by CORSIKA program for the conditions of Yakutsk Cherenkov array at the high energy range (1013-1016) eV for two primary particles (p and Fe) for different zenith angles. By depending on Breit-Wigner function for analyzing of Cherenkov light LDF, a parameterization of Cherenkov light LDF was reconstructed by depending on CORSIKA simulation as a function of primary energy. The comparison between the estimated Cherenkov light LDF with the LDF that measured on the Yakutsk EAS array gives the ability of particle identification that initiated the shower and determination of particle's energy around the knee region. The extrapolation of approximated Cherenkov light LDF for energies 20 and 30 PeV was obtained for primary particles (p and Fe).

  16. Anomalies in primary dentition: Their distribution and correlation with permanent dentition

    PubMed Central

    Mukhopadhyay, Santanu; Mitra, Sanjib

    2014-01-01

    Background: Anomalies in primary dentition are often found to be associated with anomalies in permanent dentition. Aims: This study was performed to evaluate the prevalence of supernumerary teeth, hypodontia, double teeth, and talon cusp in the primary dentition, and their effect on succedaneous permanent teeth. Materials and Methods: In this prospective cross-sectional study, we clinically investigated 2757 Bengali speaking nursery children (1474 girls and 1283 boys), of age four to six years, at their respective schools, and the presence of supernumerary teeth, hypodontia, double teeth, and talon cusp in the primary dentition were recorded. Children with anomalous primary teeth were further subjected to periapical and panoramic radiographic examination, to determine the status of the underlying permanent teeth. Results: The total prevalence of all anomalies in this study was 1.8%. A total of 38 children (21 girls and 17 boys) had anomalies. The prevalence of anomalies was as follows: Supernumerary teeth (0.4%), hypodontia (0.5%), double teeth (0.4%), and talon cusp (0.07%), in both sexes combined. Radiographic examination showed 50% of the patients (19 children) had anomalies in the permanent dentition. Conclusions: Anomalies in primary dentition exhibited a correlation with anomalies in permanent dentition. PMID:24678213

  17. Primary cilia distribution and orientation during involution of the bovine mammary gland.

    PubMed

    Biet, J; Poole, C A; Stelwagen, K; Margerison, J K; Singh, K

    2016-05-01

    The regulation of mammary gland involution occurs through multiple levels including environmental factors, hormones, and local intramammary signals. Primary cilia (PC) are signaling organelles that sense biochemical and biophysical extracellular stimuli and are vital for cellular and tissue function. The aim of this study was to examine the distribution, incidence, and orientation of PC. Furthermore, we determined changes in expression levels of the signal transducer and activator of transcription (STAT)6 at the onset of bovine mammary gland involution. Mammary tissue was collected from pasture-fed, primiparous, nonpregnant Friesian dairy cows at mid lactation (n=5 per group) killed 6-h after milking (lactating controls) and during involution after 7 and 28 d of nonmilking (NM). Fluorescent immunohistochemistry and confocal microscopy of tissue sections showed that PC were present on luminal secretory epithelial cells (SEC), myoepithelial cells (MEC), and stromal fibroblast cells (SFC). Furthermore, in all 3 experimental groups, different PC positions or orientations relative to the cell surface were identified on SEC and MEC, which projected toward the lumen and were either straight, bent, or deflected against the apical cell surface, whereas PC in SFC were confined to the interalveolar space. However, by 28-d NM, fewer PC projected into the luminal space and most appeared deflected or projected toward the interalveolar space. Furthermore, by 28-d NM, with the increase in stromal connective tissue, more PC were detected within the interalveolar and interlobular stroma. At 28-d NM, we observed a decrease in luminal cilia relative to the total number of cilia. The number of ciliated cells in the total fraction (SEC, MEC, and SFC) was the same for all 3 groups, although in the luminal fraction (SEC and MEC), PC per nuclei increased by 28-d NM relative to lactation. At all 3 stages, we detected variations in shape and orientation of PC within the same alveolus, with

  18. Distribution of primary afferent fibres in the cochlear nuclei. A silver and horseradish peroxidase (HRP) study.

    PubMed Central

    Merchan, M A; Collia, F P; Merchan, J A; Saldana, E

    1985-01-01

    Horseradish peroxidase, when injected intracochlearly, is transported transganglionically to the brain stem cochlear nuclei, thus providing an excellent method for tracing the central projection of the spiral ganglion neurons. Silver impregnation using the Cajal-de Castro method, which stains axons even when inside the bone, was used as a reference technique. The combination of both procedures led to the following conclusions. Primary cochlear afferents are found only in the ventral zone of the dorsal cochlear nucleus. In this area they cover the deep and fusiform cell layers. The molecular layer shows no HRP label. The higher concentration of primary cochlear afferents in the ventral cochlear nucleus appears in its central zone; wide areas in this nucleus are not labelled at all. A thin bundle of primary cochlear afferents runs parallel to, and beneath, the granular region. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 PMID:4077711

  19. Multiple output power supply circuit for an ion engine with shared upper inverter

    NASA Technical Reports Server (NTRS)

    Cardwell, Jr., Gilbert I. (Inventor); Phelps, Thomas K. (Inventor)

    2001-01-01

    A power supply circuit for an ion engine suitable for a spacecraft is coupled to a bus having a bus input and a bus return. The power supply circuit has a first primary winding of a first transformer. An upper inverter circuit is coupled to the bus input and the first primary winding. The power supply circuit further includes a first lower inverter circuit coupled to the bus return and the first primary winding. The second primary winding of a second transformer is coupled to the upper inverter circuit. A second lower inverter circuit is coupled to the bus return and the second primary winding.

  20. Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons.

    PubMed

    Bao, Lan

    2015-01-01

    Voltage-gated sodium channels (Navs) comprise at least nine pore-forming α subunits. Of these, Nav1.6, Nav1.7, Nav1.8 and Nav1.9 are the most frequently studied in primary sensory neurons located in the dorsal root ganglion and are mainly localized to the cytoplasm. A large pool of intracellular Navs raises the possibility that changes in Nav trafficking could alter channel function. The molecular mediators of Nav trafficking mainly consist of signals within the Navs themselves, interacting proteins and extracellular factors. The surface expression of Navs is achieved by escape from the endoplasmic reticulum and proteasome degradation, forward trafficking and plasma membrane anchoring, and it is also regulated by channel phosphorylation and ubiquitination in primary sensory neurons. Axonal transport and localization of Navs in afferent fibers involves the motor protein KIF5B and scaffold proteins, including contactin and PDZ domain containing 2. Localization of Nav1.6 to the nodes of Ranvier in myelinated fibers of primary sensory neurons requires node formation and the submembrane cytoskeletal protein complex. These findings inform our understanding of the molecular and cellular mechanisms underlying Nav trafficking in primary sensory neurons. PMID:26423360

  1. How Primary School Students Understand Mains Electricity and Its Distribution. Research Report

    ERIC Educational Resources Information Center

    Pilatou, Vassiliki; Stavridou, Heleni

    2004-01-01

    The aim of this study was to detect primary students' conceptions about the origin and conveyance of electric current and about the connection of household electric appliances. In total, 383 students (aged 11-12) from the town of Volos, Greece, participated; 213 of them drawn from experimental classes and 170 from control groups. The results…

  2. Uneven Distribution of Novice Teachers in the Chilean Primary School System

    ERIC Educational Resources Information Center

    Meckes, Lorena; Bascope, Martin

    2012-01-01

    This study examines the allocation of novice primary teachers in Chilean schools, looking at their characteristics and at the attributes of the schools at which they are hired after having completed their initial teacher training. The study reveals that in Chile, more qualified novice teachers are more prone to get jobs in socio-economically…

  3. History of Physics as a Tool to Detect the Conceptual Difficulties Experienced by Students: The Case of Simple Electric Circuits in Primary Education

    ERIC Educational Resources Information Center

    Leone, Matteo

    2014-01-01

    The present paper advocates the use of History of Science into the teaching of science in primary education through a case study in the field of electricity. In this study, which provides both historical and experimental evidence, a number of conceptual difficulties faced by early nineteenth century physicists are shown to be a useful tool to…

  4. The problem of optimizing the water chemistry used in the primary coolant circuit of a nuclear power station equipped with VVER reactors under the conditions of longer fuel cycle campaigns and increased capacity of power units

    NASA Astrophysics Data System (ADS)

    Sharafutdinov, R. B.; Kharitonova, N. L.

    2011-05-01

    It is shown that the optimal water chemistry of the primary coolant circuit must be substantiated while introducing measures aimed at increasing the power output in operating power units and for the project called AES-2006/AES TOI (a typical optimized project of a nuclear power station with enhanced information support). The experience gained from operation of PWR reactors with an elongated fuel cycle at an increased level of power is analyzed. Conditions under which boron compounds are locally concentrated on the fuel rod surfaces (the hideout phenomenon) and axial offset anomaly occurs are enlisted, and the influence of lithium on the hideout in the pores of deposits on the surfaces of fuel assemblies is shown.

  5. The influence of personal blast protection on the distribution and severity of primary blast gut injury.

    PubMed

    Cripps, N P; Cooper, G J

    1996-03-01

    Primary blast injuries have been recognized since World War I when the most significant reported injury was to the lung. The prevalence of injury to tissues containing air was underlined by the frequency of gut blast injury in underwater explosions mostly reported during World War II. Gut injury is the most likely cause of mortality after the more immediate effects of pulmonary primary blast injury. Effective protection has been achieved for lungs exposed to short duration external blast waves by the placement of stress wave decouplers on to the thoracoabdominal wall in a pig model, thus modifying the energy coupled into the body. A combination of two densities of glass-reinforced plastic plate and Plastazote foam (GRP/PZ) effectively eliminated pulmonary injury in 17 protected animals, compared with the production of severe blast lung in nine unprotected animals (p < 0.001). Partial pulmonary protection was achieved using a plasticized lead and plastazote foam decoupling combination (PbPVC/PZ) in a further group of 10 animals. Peak incident overpressures were not significantly different in any group. Small bowel contusions were highly significantly reduced in the GRP/PZ groups when compared with unprotected animals and with PbPVC protected animals (both p < 0.001); no significant reduction was observed in the summed colonic contusion size in any protected group. Intestinal perforations were also highly significantly reduced in both GRP/PZ groups (p < 0.001). Primary pulmonary blast injury and probably small bowel injury are caused by the propagation of coupled stress waves within the body. Elimination of these injuries implies prevention of stress wave propagation. Because colonic injury was not prevented by the same protection, a different mechanism for the injury is suggested: transmission and propagation of shear waves. These findings have important implications for blast protection and the clinical management of primary blast casualties. PMID:8606411

  6. Distribution of plankton lipids and their role in the biological transformation of Antarctic primary production

    NASA Astrophysics Data System (ADS)

    Mayzaud, P.; Errhif, A.; Bedo, A.

    1998-11-01

    Production and transfer of lipid through the Antarctic food web is reviewed for the Indian Ocean sector. The slow settling fine particles showed a marked inter-annual variability in biochemical composition with an increase in lipid content as % organic carbon. Comparison of the fatty acid spectra of different size categories of organic particles indicated that fine particles are dominated by saturated, monoenoic and branched acids, while larger material (50-100 μm, 200-500 μm net collected fractions) displayed a signature dominated by polyunsaturated acids. Zooplankton taxa displayed different strategies of lipid accumulation. Lipid content was highest in Thysanoessa macrura females and copepodite stages of Calanus propinquus. Relatively low levels were recorded for juveniles and male stages of euphausiids. Reserve lipids varied with species: C. propinquus showed equal content of triglycerides and wax esters, T. macrura showed a dominance of wax esters and Euphausia superba and Themisto gaudichaudii accumulated only triglycerides. Computed as carbon equivalent and integrated over 200 m, lipids in slow settling particles represented 22.6% of annual primary production. Similar computation with mesozooplankton and E. superba data on biomass and population structure from several summer cruises indicated values of carbon accumulation as lipid reserves and egg production of 4.2 and 0.1% of annual primary production for copepods and 4.4 and 3.8% for E. superba. When all trophic levels are considered, the overall mean exceeded 30% of annual primary production.

  7. Influence of polydisperse distributions of both primary particle and aggregate size on soot temperature in low-fluence LII

    NASA Astrophysics Data System (ADS)

    Liu, F.; Yang, M.; Hill, F. A.; Snelling, D. R.; Smallwood, G. J.

    2006-06-01

    An improved aggregate-based low-fluence laser-induced incandescence (LII) model has been developed. The shielding effect in heat conduction between aggregated soot particles and the surrounding gas was modeled using the concept of the equivalent heat transfer sphere. The diameter of such an equivalent sphere was determined from direct simulation Monte Carlo calculations in the free molecular regime as functions of the aggregate size and the thermal accommodation coefficient of soot. Both the primary soot particle diameter and the aggregate size distributions are assumed to be lognormal. The effective temperature of a soot particle ensemble containing different primary particle diameters and aggregate sizes in the laser probe volume was calculated based on the ratio of the total thermal radiation intensities of soot particles at 400 and 780 nm to simulate the experimentally measured soot particle temperature using two-color optical pyrometry. The effect of primary particle diameter polydispersity is in general important and should be considered. The effect of aggregate size polydispersity is relatively unimportant when the heat conduction between the primary particles and the surrounding gas takes place in the free-molecular regime; however, it starts to become important when the heat conduction process occurs in the near transition regime. The model developed in this study was also applied to the re-determination of the thermal accommodation coefficient of soot in an atmospheric pressure laminar ethylene diffusion flame.

  8. LOGIC CIRCUIT

    DOEpatents

    Strong, G.H.; Faught, M.L.

    1963-12-24

    A device for safety rod counting in a nuclear reactor is described. A Wheatstone bridge circuit is adapted to prevent de-energizing the hopper coils of a ball backup system if safety rods, sufficient in total control effect, properly enter the reactor core to effect shut down. A plurality of resistances form one arm of the bridge, each resistance being associated with a particular safety rod and weighted in value according to the control effect of the particular safety rod. Switching means are used to switch each of the resistances in and out of the bridge circuit responsive to the presence of a particular safety rod in its effective position in the reactor core and responsive to the attainment of a predetermined velocity by a particular safety rod enroute to its effective position. The bridge is unbalanced in one direction during normal reactor operation prior to the generation of a scram signal and the switching means and resistances are adapted to unbalance the bridge in the opposite direction if the safety rods produce a predetermined amount of control effect in response to the scram signal. The bridge unbalance reversal is then utilized to prevent the actuation of the ball backup system, or, conversely, a failure of the safety rods to produce the predetermined effect produces no unbalance reversal and the ball backup system is actuated. (AEC)

  9. The Distribution of Primary School Quality within High- and Low-Income Countries.

    ERIC Educational Resources Information Center

    Heyneman, Stephen P.; Loxley, William A.

    1983-01-01

    Quality of schools is a critical resource in the production of school achievement, individual and national. Countries with a scarcity of resources (transportation, administration, and management) would be expected to perform worse in distributing any resource, especially one of such complexity as school quality, but this does not seem to occur.…

  10. THE ANALYTICAL STRUCTURE OF THE PRIMARY INTERSTELLAR HELIUM DISTRIBUTION FUNCTION IN THE HELIOSPHERE

    SciTech Connect

    Lee, Martin A.; Möbius, Eberhard; Leonard, Trevor W.

    2015-10-15

    A new analytical model based on the previous work of Lee et al. is presented for the distribution of interstellar helium in the heliosphere. The model is tailored for comparison with the IBEX-Lo observations in order to determine the bulk velocity and temperature of helium in the local interstellar cloud. The model includes solar gravity, spherically symmetric stationary ionization rates, transformation to the Earth/IBEX frame of reference, the IBEX viewing geometry with small spin-axis tilt, and integration of the atom differential intensity over energy and the instrument collimator solid angle. The analysis employs an expansion of the count rate about the peak of the velocity distribution to second order in the magnitudes of several small quantities: the ratio of the helium thermal speed to its bulk speed, the angle between the bulk velocity and the ecliptic, the two angles describing the tilt of the IBEX spin-axis away from Sun-pointing, the collimator angular width, and the angular difference between the observing longitude and the longitude where the projection of the bulk velocity onto the ecliptic is tangential to Earth's orbit. The model reveals the evolving ellipsoidal shape of the helium distribution as it moves along its average hyperbolic orbit. For specified interstellar parameters, the model predicts the latitudinal and longitudinal structure of the helium distribution. The model is in reasonable agreement with IBEX observations and the predictions of the other available models.

  11. 30 CFR 56.6402 - Deenergized circuits near detonators.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Deenergized circuits near detonators. 56.6402... Electric Blasting § 56.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized. Such circuits need not...

  12. 30 CFR 56.6402 - Deenergized circuits near detonators.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Deenergized circuits near detonators. 56.6402... Electric Blasting § 56.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized. Such circuits need not...

  13. 30 CFR 56.6402 - Deenergized circuits near detonators.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Deenergized circuits near detonators. 56.6402... Electric Blasting § 56.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized. Such circuits need not...

  14. 30 CFR 56.6402 - Deenergized circuits near detonators.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Deenergized circuits near detonators. 56.6402... Electric Blasting § 56.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized. Such circuits need not...

  15. 30 CFR 56.6402 - Deenergized circuits near detonators.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Deenergized circuits near detonators. 56.6402... Electric Blasting § 56.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized. Such circuits need not...

  16. One Size Does Not Fit All: The Impact of Primary Vaccine Container Size on Vaccine Distribution and Delivery

    PubMed Central

    Haidari, Leila A.; Wahl, Brian; Brown, Shawn T.; Privor-Dumm, Lois; Wallman-Stokes, Cecily; Gorham, Katie; Connor, Diana L.; Wateska, Angela R.; Schreiber, Benjamin; Dicko, Hamadou; Jaillard, Philippe; Avella, Melanie; Lee, Bruce Y.

    2015-01-01

    BACKGROUND While the size and type of a vaccine container (i.e., primary container) can have many implications on the safety and convenience of a vaccination session, another important but potentially overlooked consideration is how the design of the primary container may affect the distribution of the vaccine, its resulting cost, and whether the vial is ultimately opened. METHODS Using our HERMES software platform, we developed a simulation model of the World Health Organization Expanded Program on Immunization supply chain for the Republic of Benin and used the model to explore the effects of different primary containers for various vaccine antigens. RESULTS Replacing vaccines with presentations containing fewer doses per vial reduced vaccine availability (proportion of people arriving for vaccines who are successfully immunized) by as much as 13% (from 73% at baseline) and raised logistics costs by up to $0.06 per dose administered (from $0.25 at baseline) due to increased bottlenecks, while reducing total costs by as much as $0.15 per dose administered (from $2.52 at baseline) due to lower open vial wastage. Primary containers with a greater number of doses per vial each improved vaccine availability by 19% and reduced logistics costs by $0.05 per dose administered, while raising the total costs by up to $0.25 per dose administered due to greater vaccine procurement needs. Changes in supply chain performance were more extreme in departments with greater constraints. Implementing a vial opening threshold reversed the direction of many of these effects. CONCLUSIONS Our results show that one size may not fit all when choosing a primary vaccine container. Rather, the choice depends on characteristics of the vaccine, the vaccine supply chain, immunization session size, and goals of decision-makers. In fact, the optimal vial size may vary among locations within a country. Simulation modeling can help identify tailored approaches to improve availability and efficiency

  17. Phylogeography in continuous space: coupling species distribution models and circuit theory to assess the effect of contiguous migration at different climatic periods on genetic differentiation in Busseola fusca (Lepidoptera: Noctuidae).

    PubMed

    Dupas, S; le Ru, B; Branca, A; Faure, N; Gigot, G; Campagne, P; Sezonlin, M; Ndemah, R; Ong'amo, G; Calatayud, P-A; Silvain, J-F

    2014-05-01

    Current population genetic models fail to cope with genetic differentiation for species with large, contiguous and heterogeneous distribution. We show that in such a case, genetic differentiation can be predicted at equilibrium by circuit theory, where conductance corresponds to abundance in species distribution models (SDMs). Circuit-SDM approach was used for the phylogeographic study of the lepidopteran cereal stemborer Busseola fuscaFüller (Noctuidae) across sub-Saharan Africa. Species abundance was surveyed across its distribution range. SDMs were optimized and selected by cross-validation. Relationship between observed matrices of genetic differentiation between individuals, and between matrices of resistance distance was assessed through Mantel tests and redundancy discriminant analyses (RDAs). A total of 628 individuals from 130 localities in 17 countries were genotyped at seven microsatellite loci. Six population clusters were found based on a Bayesian analysis. The eastern margin of Dahomey gap between East and West Africa was the main factor of genetic differentiation. The SDM projections at present, last interglacial and last glacial maximum periods were used for the estimation of circuit resistance between locations of genotyped individuals. For all periods of time, when using either all individuals or only East African individuals, partial Mantel r and RDA conditioning on geographic distance were found significant. Under future projections (year 2080), partial r and RDA significance were different. From this study, it is concluded that analytical solutions provided by circuit theory are useful for the evolutionary management of populations and for phylogeographic analysis when coalescence times are not accessible by approximate Bayesian simulations.

  18. Commutation circuit for an HVDC circuit breaker

    DOEpatents

    Premerlani, W.J.

    1981-11-10

    A commutation circuit for a high voltage DC circuit breaker incorporates a resistor capacitor combination and a charging circuit connected to the main breaker, such that a commutating capacitor is discharged in opposition to the load current to force the current in an arc after breaker opening to zero to facilitate arc interruption. In a particular embodiment, a normally open commutating circuit is connected across the contacts of a main DC circuit breaker to absorb the inductive system energy trapped by breaker opening and to limit recovery voltages to a level tolerable by the commutating circuit components. 13 figs.

  19. Commutation circuit for an HVDC circuit breaker

    DOEpatents

    Premerlani, William J.

    1981-01-01

    A commutation circuit for a high voltage DC circuit breaker incorporates a resistor capacitor combination and a charging circuit connected to the main breaker, such that a commutating capacitor is discharged in opposition to the load current to force the current in an arc after breaker opening to zero to facilitate arc interruption. In a particular embodiment, a normally open commutating circuit is connected across the contacts of a main DC circuit breaker to absorb the inductive system energy trapped by breaker opening and to limit recovery voltages to a level tolerable by the commutating circuit components.

  20. An effort to spread decision aids in five California primary care practices yielded low distribution, highlighting hurdles.

    PubMed

    Lin, Grace A; Halley, Meghan; Rendle, Katharine A S; Tietbohl, Caroline; May, Suepattra G; Trujillo, Laurel; Frosch, Dominick L

    2013-02-01

    Despite the proven efficacy of decision aids as interventions for increasing patient engagement and facilitating shared decision making, they are not used routinely in clinical care. Findings from a project designed to achieve such integration, conducted at five primary care practices in 2010-12, document low rates of distribution of decision aids to eligible patients due for colorectal cancer screening (9.3 percent) and experiencing back pain (10.7 percent). There were also no lasting increases in distribution rates in response to training sessions and other promotional activities for physicians and clinic staff. The results of focus groups, ethnographic field notes, and surveys suggest that major structural and cultural changes in health care practice and policy are necessary to achieve the levels of use of decision aids and shared decision making in routine practice envisioned in current policy. Among these changes are ongoing incentives for use, physician training, and a team-based practice model in which all care team members bear formal responsibility for the use of decision aids in routine primary care.

  1. Phytoplankton Chl a, primary production and nutrient distributions across a coastal frontal zone off Georgia, U.S.A.

    NASA Astrophysics Data System (ADS)

    Yoder, James A.; Verity, Peter G.; Bishop, S. Stephen; Hoge, Frank E.

    1993-02-01

    Using results obtained by ship and aircraft surveys of near-shore waters off Georgia, U.S.A. we describe the gradients in major plant nutrients, near-surface cholorphyll (Chl a) and near-surface primary production in relation to near-surface density gradients of a coastal frontal zone. The results show that a relatively narrow band (˜10 km wide) of high phytoplankton biomass (Chl a) is a ubiquitous feature of the shoreward side of the coastal frontal zone. Chl a decreases across the frontal zone as salinity increases and near surface Chl a concentrations are approximately 10-fold greater in the high Chl a band than on the seaward side of the frontal zone. Near-surface phosphate and silicate concentrations are distributed similarly to Chl a. In contrast to silicate and phosphate, we did not detect significant cross-shelf gradients of inorganic nitrogen (N) concentrations. The distributions imply high rates of primary production in the coastal band throughout the year, total consumption of available inorganic N brought in by rivers or other sources and high rates of N recycling.

  2. Structure of electron tracks in water. 2. Distribution of primary ionizations and excitations in water radiolysis. [accelerated electrons

    SciTech Connect

    Pimblott, S.M.; Mozumder, A. )

    1991-09-19

    A procedure for the calculation of entity-specific ionization and excitation probabilities for water radiolysis at low linear energy transfer (LET) has been developed. The technique pays due attention to the effects of the ionization threshold and the energy dependence of the ionization efficiency. The numbers of primary ionizations and excitations are not directly proportional to the spur energy. At a given spur energy, ionization follows a binomial distribution subject to an energetically possible maximum. The excitation distribution for a spur of given energy and with a given number of ionizations is given by a geometric series. The occurrence probabilities depend upon the cross sections of ionization, excitation, and other inferior processes. Following the low-LET radiolysis of liquid water the most probable spurs contain one ionization, two ionizations, or one ionization and one excitation, while in water vapor they contain either one ionization or one excitation. In liquid water the most probable outcomes for spurs corresponding to the most probable energy loss (22 eV) and to the mean energy loss (38 eV) are one ionization and one excitation, and two ionizations and one excitation, respectively. In the vapor, the most probable energy loss is 14 eV which results in one ionization or one excitation and the mean energy loss is 34 eV for which the spur of maximum probability contains one ionization and two excitations. The total calculated primary yields for low-LET radiolysis are in approximate agreement with experiment in both phases.

  3. Distribution of phototrophic populations and primary production in a microbial mat from the Ebro Delta, Spain.

    PubMed

    Martínez-Alonso, Maira; Mir, Joan; Caumette, Pierre; Gaju, Núria; Guerrero, Ricardo; Esteve, Isabel

    2004-03-01

    Microbial mats arising in the sand flats of the Ebro Delta (Tarragona, Spain) were investigated during the summer season, when the community was highly developed. These mats are composed of three pigmented layers of phototrophic organisms, an upper brown layer mainly composed of Lyngbya aestuarii and diatoms, an intermediate green layer of the cyanobacterium Microcoleus chthonoplastes, and an underlying pink layer of a so-far unidentified purple sulfur bacterium. In the photic zone, oxygenic phototrophs constitute about 58% of total photosynthetic biomass, measured as biovolume, and anoxygenic phototrophs represent 42%. Diatoms constitute 11.8% of the oxygenic biomass, M. chthonoplastes 61.2%, and L. aestuarii and coccoid cyanobacteria 20.6 and 6.4%, respectively. In this laminated community, organic matter has an autochthonous origin, and photosynthesis is the most important source of organic carbon. Oxygen production reaches up to 27.2 mmol O(2) m(-2) h(-1), measured at 1000 microE m(-2) s(-1) light intensity, whereas oxidation of sulfide in the light has been calculated to be 18.6 mmol S m(-2) h(-1). This amount represents 26% of the total photosynthetic production in terms of photoassimilated carbon, demonstrating the important role of anoxygenic phototrophs as primary producers in the pink layer of Ebro Delta microbial mats.

  4. Biosynthesis and polarized distribution of neutral endopeptidase in primary cultures of kidney proximal tubule cells.

    PubMed Central

    Jalal, F; Dehbi, M; Berteloot, A; Crine, P

    1994-01-01

    When cultured in defined medium, kidney proximal convoluted tubule (PCT) cells form a homogeneous population and retain a number of differentiated functions. To characterize this cell system further as a functional model of epithelial polarity, we investigated the biogenic pathway of neutral endopeptidase (NEP), one of the most abundant microvillar membrane proteins in intestinal and kidney cells. We showed that, in contrast with some tumoral cell lines, RNA extracted from PCT cells shows the presence of a single mRNA species encoding NEP. Pulse-chase studies followed by selective immunoprecipitation of NEP molecules present either at the cell surface or in intracellular cell compartments showed that newly synthesized NEP molecules reached the cell surface as early as 30 min after the beginning of the chase with maximum cell surface expression at 60 min. When grown on semipermeable supports, PCT cells were found to target NEP exclusively to the apical plasma membrane. Similar results have been described using MDCK cells to study targeting of recombinant NEP. Thus primary cultures of PCT cells represent a new model with which to investigate the biogenic pathway of endogenous proteins in native epithelial cells. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 PMID:7945190

  5. Methods and theory in bone modeling drift: comparing spatial analyses of primary bone distributions in the human humerus.

    PubMed

    Maggiano, Corey M; Maggiano, Isabel S; Tiesler, Vera G; Chi-Keb, Julio R; Stout, Sam D

    2016-01-01

    This study compares two novel methods quantifying bone shaft tissue distributions, and relates observations on human humeral growth patterns for applications in anthropological and anatomical research. Microstructural variation in compact bone occurs due to developmental and mechanically adaptive circumstances that are 'recorded' by forming bone and are important for interpretations of growth, health, physical activity, adaptation, and identity in the past and present. Those interpretations hinge on a detailed understanding of the modeling process by which bones achieve their diametric shape, diaphyseal curvature, and general position relative to other elements. Bone modeling is a complex aspect of growth, potentially causing the shaft to drift transversely through formation and resorption on opposing cortices. Unfortunately, the specifics of modeling drift are largely unknown for most skeletal elements. Moreover, bone modeling has seen little quantitative methodological development compared with secondary bone processes, such as intracortical remodeling. The techniques proposed here, starburst point-count and 45° cross-polarization hand-drawn histomorphometry, permit the statistical and populational analysis of human primary tissue distributions and provide similar results despite being suitable for different applications. This analysis of a pooled archaeological and modern skeletal sample confirms the importance of extreme asymmetry in bone modeling as a major determinant of microstructural variation in diaphyses. Specifically, humeral drift is posteromedial in the human humerus, accompanied by a significant rotational trend. In general, results encourage the usage of endocortical primary bone distributions as an indicator and summary of bone modeling drift, enabling quantitative analysis by direction and proportion in other elements and populations.

  6. Effect of warming on the altitudinal distribution of soil moisture and net primary production in a synthetic mountain catchment

    NASA Astrophysics Data System (ADS)

    Maneta, M. P.

    2011-12-01

    Marco P Maneta Dept of Geosciences, University of Montana, Missoula, MT 59812 Generally, the trend towards a warmer climate is thought to lead to a more water-stressed environment. This signal has been sought and detected in the analysis of snow water equivalent and river discharge data from the network of SNOTEL sites and river gauges, in the frequency of forest fires and in the shift of species uphill in elevation. While at a large scale this trend is well documented, local departures are expected, especially in regions of complex topography. Recent studies show that in mountain regions, small scale atmospheric processes can significantly alter the local climate leading to counterintuitive results such as increased precipitation and increased snowpack that results in increased moisture regimes and larger spring peak stream flows. A recent study has observed a significant downhill shift in the optimal elevation of plant species in the last century in California, this shift being attributed to increased energy and moisture availability and demonstrating that temperature and energy alone, as used in many ecological models, do not adequately explain the distribution of vegetation. Using an ecohydrologic model on a synthetic mountain setting we investigate how changes in the temperature regime (defined by the average temperature and lapse rate) and altitudinal distribution of precipitation lead to changes in the altitudinal distribution of soil moisture and primary production, including a downhill shift in primary production. This is because earlier snowmelt increases the amount of available water despite the expected increase of atmospheric water demand associated with higher temperatures.

  7. Distribution and morphology of nitrergic neurons across functional domains of the rat primary somatosensory cortex

    PubMed Central

    Nogueira-Campos, Anaelli A.; Finamore, Deborah M.; Imbiriba, Luis A.; Houzel, Jean C.; Franca, João G.

    2012-01-01

    The rat primary somatosensory cortex (S1) is remarkable for its conspicuous vertical compartmentalization in barrels and septal columns, which are additionally stratified in horizontal layers. Whereas excitatory neurons from each of these compartments perform different types of processing, the role of interneurons is much less clear. Among the numerous types of GABAergic interneurons, those producing nitric oxide (NO) are especially puzzling, since this gaseous messenger can modulate neural activity, synaptic plasticity, and neurovascular coupling. We used a quantitative morphological approach to investigate whether nitrergic interneurons, which might therefore be considered both as NO volume diffusers and as elements of local circuitry, display features that could relate to barrel cortex architecture. In fixed brain sections, nitrergic interneurons can be revealed by histochemical processing for NADPH-diaphorase (NADPHd). Here, the dendritic arbors of nitrergic neurons from different compartments of area S1 were 3D reconstructed from serial 200 μm thick sections, using 100x objective and the Neurolucida system. Standard morphological parameters were extracted for all individual arbors and compared across columns and layers. Wedge analysis was used to compute dendritic orientation indices. Supragranular (SG) layers displayed the highest density of nitrergic neurons, whereas layer IV contained nitrergic neurons with largest soma area. The highest nitrergic neuronal density was found in septa, where dendrites were previously characterized as more extense and ramified than in barrels. Dendritic arbors were not confined to the boundaries of the column nor layer of their respective soma, being mostly double-tufted and vertically oriented, except in SG layers. These data strongly suggest that nitrergic interneurons adapt their morphology to the dynamics of processing performed by cortical compartments. PMID:23133407

  8. A simple tachometer circuit

    NASA Technical Reports Server (NTRS)

    Dimeff, J.

    1972-01-01

    Electric circuit to measure frequency of repetitive sinusoidal or rectangular wave is presented. Components of electric circuit and method of operation are explained. Application of circuit as tachometer for automobile is discussed.

  9. Photomultiplier blanking circuit

    NASA Technical Reports Server (NTRS)

    Mcclenahan, J. O.

    1972-01-01

    Circuit for protecting photomultiplier equipment from current surges which occur when exposed to brilliant illumination is discussed. Components of circuit and details of operation are provided. Circuit diagram to show action of blanking pulse on zener diode is included.

  10. Environmental distribution and population biology of Candidatus Accumulibacter, a primary agent of biological phosphorus removal.

    PubMed

    Peterson, S Brook; Warnecke, Falk; Madejska, Julita; McMahon, Katherine D; Hugenholtz, Philip

    2008-10-01

    Members of the uncultured bacterial genus Candidatus Accumulibacter are capable of intracellular accumulation of inorganic phosphate in activated sludge wastewater treatment plants (WWTPs) performing enhanced biological phosphorus removal, but were also recently shown to inhabit freshwater and estuarine sediments. Additionally, metagenomic sequencing of two bioreactor cultures enriched in Candidatus Accumulibacter, but housed on separate continents, revealed the potential for global dispersal of particular Candidatus Accumulibacter strains, which we hypothesize is facilitated by the ability of Candidatus Accumulibacter to persist in environmental habitats. In the current study, we used sequencing of a phylogenetic marker, the ppk1 gene, to characterize Candidatus Accumulibacter populations in diverse environments, at varying distances from WWTPs. We discovered several new lineages of Candidatus Accumulibacter which had not previously been detected in WWTPs, and also uncovered new diversity and structure within previously detected lineages. Habitat characteristics were found to be a key determinant of Candidatus Accumulibacter lineage distribution while, as predicted, geographic distance played little role in limiting dispersal on a regional scale. However, on a local scale, enrichment of particular Candidatus Accumulibacter lineages in WWTP appeared to impact local environmental populations. These results provide evidence of ecological differences among Candidatus Accumulibacter lineages. PMID:18643843

  11. Patterns of distribution of inorganic nutrients in Red Sea and their implications to primary production

    NASA Astrophysics Data System (ADS)

    Wafar, Mohideen; Qurban, Mohammad Ali; Ashraf, Mohamed; Manikandan, K. P.; Flandez, Ace Vincent; Balala, Arvin C.

    2016-04-01

    This paper presents data on inorganic nutrients obtained in several transects within Saudi Arabian waters of the Red Sea in 2012-2015. Increase in their concentrations from north to south is not monotonously linear but is punctuated by regions of high concentrations alternating with those of low concentrations, regardless of the type of nutrient (N, P or Si), season and location. Such a type of distribution could be only explained in terms of eddy circulations within the Red Sea basin. The enrichment with nutrients of the boundary currents of the eddies could be explained partly by entrainment of Gulf of Aden Intermediate Water in the eddies and the mixing of the latter with the underlying Red Sea Deep Water, and partly by a higher biological productivity in the peripheries of the eddies. These results have two major implications for our understanding of biogeochemical cycles in the Red Sea. The first is that the eddy-associated injection of nutrients into the euphotic zone could cause higher levels of production over a substantial spread of the Red Sea. The second is that the anticyclonic eddies may function as traps of nutrients and in that event, their peripheries and centers may function as independent mesocosms.

  12. Distribution of Root-Associated Bacterial Communities Along a Salt-Marsh Primary Succession

    PubMed Central

    Wang, Miao; Yang, Pu; Falcão Salles, Joana

    2016-01-01

    Proper quantification of the relative influence of soil and plant host on the root-associated microbiome can only be achieved by studying its distribution along an environmental gradient. Here, we used an undisturbed salt marsh chronosequence to study the bacterial communities associated with the soil, rhizosphere and the root endopshere of Limonium vulgare using 454-pyrosequencing. We hypothesize that the selective force exerted by plants rather than soil would regulate the dynamics of the root-associated bacterial assembly along the chronosequence. Our results showed that the soil and rhizosphere bacterial communities were phylogenetically more diverse than those in the endosphere. Moreover, the diversity of the rhizosphere microbiome followed the increased complexity of the abiotic and biotic factors during succession while remaining constant in the other microbiomes. Multivariate analyses showed that the rhizosphere and soil-associated communities clustered by successional stages, whereas the endosphere communities were dispersed. Interestingly, the endosphere microbiome showed higher turnover, while the bulk and rhizosphere soil microbiomes became more similar at the end of the succession. Overall, we showed that soil characteristics exerted an overriding influence on the rhizosphere microbiome, although plant effect led to a clear diversity pattern along the succession. Conversely, the endosphere microbiome was barely affected by any of the environmental measurements and very distinct from other communities. PMID:26779222

  13. Transverse momentum distribution of primary charged particles in the p-Pb interactions using HIJING 1.0

    NASA Astrophysics Data System (ADS)

    Tabassam, U.; Ali, Y.; Suleymanov, M.; Bhatti, A. S.; Butt, J. B.; Amjad, M. S.

    2016-08-01

    The shape of the transverse momentum (pT) distribution of primary charged particles in minimum bias (nonsingle-diffractive) p-Pb collisions at sNN = 5.02TeV is studied in the pseudorapidity regions: |η| < 0.3, 0.3 < η < 0.8 and 0.8 < η < 1.3 and in the transverse momentum range 0.5 < pT < 20GeV/c using simulated data produced with the HIJING 1.0 code. These are compared with the ALICE data measured by the ALICE detector at the LHC. In the model, the central and forward η-regions differ more than in the ALICE data and due to this fact HIJING 1.0 cannot describe well the high pT region in the pT distributions. The comparison of results from simulation implies that the HIJING 1.0 considered narrower pseudorapidity distribution for the charged particles than it is in the ALICE data. It cannot take into account satisfactorily leading effect due to the asymmetric p-Pb fragmentation.

  14. Primary Accretion and Turbulent Cascades: Scale-Dependence of Particle Concentration Multiplier Probability Distribution Functions

    NASA Astrophysics Data System (ADS)

    Cuzzi, Jeffrey N.; Weston, B.; Shariff, K.

    2013-10-01

    Primitive bodies with 10s-100s of km diameter (or even larger) may form directly from small nebula constituents, bypassing the step-by-step “incremental growth” that faces a variety of barriers at cm, m, and even 1-10km sizes. In the scenario of Cuzzi et al (Icarus 2010 and LPSC 2012; see also Chambers Icarus 2010) the immediate precursors of 10-100km diameter asteroid formation are dense clumps of chondrule-(mm-) size objects. These predictions utilize a so-called cascade model, which is popular in turbulence studies. One of its usual assumptions is that certain statistical properties of the process (the so-called multiplier pdfs p(m)) are scale-independent within a cascade of energy from large eddy scales to smaller scales. In similar analyses, Pan et al (2011 ApJ) found discrepancies with results of Cuzzi and coworkers; one possibility was that p(m) for particle concentration is not scale-independent. To assess the situation we have analyzed recent 3D direct numerical simulations of particles in turbulence covering a much wider range of scales than analyzed by either Cuzzi and coworkers or by Pan and coworkers (see Bec et al 2010, J. Flu. Mech 646, 527). We calculated p(m) at scales ranging from 45-1024η where η is the Kolmogorov scale, for both particles with a range of stopping times spanning the optimum value, and for energy dissipation in the fluid. For comparison, the p(m) for dissipation have been observed to be scale-independent in atmospheric flows (at much larger Reynolds number) for scales of at least 30-3000η. We found that, in the numerical simulations, the multiplier distributions for both particle concentration and fluid dissipation are as expected at scales of tens of η, but both become narrower and less intermittent at larger scales. This is consistent with observations of atmospheric flows showing scale independence to >3000η if scale-free behavior is established only after some number 10 of large-scale bifurcations (at scales perhaps

  15. Records and Distribution of New World Phlebotomine Sand Flies (Psychodidae, Diptera), With Special Emphasis on Primary Types and Species Diversity.

    PubMed

    Rueda, Leopoldo M; Foley, Desmond H; Pecor, David; Wolkoff, Matthew

    2015-01-01

    This article includes the records and distribution of Phlebotomine sand flies (Psychodidae, Diptera) in the New World based on the specimen collections housed in 2 repositories, the US National Museum of Natural History and the Museum of Entomology, Florida State Collection of Arthropods. Approximately 128 species have primary types housed in the 2 repositories, including holotypes (47 species, 3 subspecies), "types" (7 species), allotypes (52 species, 6 subspecies), lectotypes (4 species), paratypes (93 species, 10 subspecies), and neoallotype (1 species), mounted on slides, with a total of 1,107 type slides. For species diversity, collection data from 24 countries in the sand fly database were analyzed according to the number of species present, specimen records, decade of collections, and countries where collections were conducted.

  16. Establishment of a primary hepatocyte culture from the small Indian mongoose (Herpestes auropunctatus) and distribution of mercury in liver tissue.

    PubMed

    Horai, Sawako; Yanagi, Kumiko; Kaname, Tadashi; Yamamoto, Masatatsu; Watanabe, Izumi; Ogura, Go; Abe, Shintaro; Tanabe, Shinsuke; Furukawa, Tatsuhiko

    2014-11-01

    The present study established a primary hepatocyte culture for the small Indian mongoose (Herpestes auropunctatus). To determine the suitable medium for growing the primary hepatic cells of this species, we compared the condition of cells cultured in three media that are frequently used for mammalian cell culture: Dulbecco's Modified Eagle's Medium, RPMI-1640, and William's E. Of these, William's E medium was best suited for culturing the hepatic cells of this species. Using periodic acid-Schiff staining and ultrastructural observations, we demonstrated the cells collected from mongoose livers were hepatocytes. To evaluate the distribution of mercury (Hg) in the liver tissue, we carried out autometallography staining. Most of the Hg compounds were found in the central region of hepatic lobules. Smooth endoplasmic reticulum, which plays a role inxenobiotic metabolism, lipid/cholesterol metabolism, and the digestion and detoxification of lipophilic substances is grown in this area. This suggested that Hg colocalized with smooth endoplasmic reticulum. The results of the present study could be useful to identify the detoxification systems of wildlife with high Hg content in the body, and to evaluate the susceptibility of wildlife to Hg toxicity. PMID:25142347

  17. 30 CFR 75.800-4 - Testing, examination, and maintenance of circuit breakers; record.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Underground High-Voltage Distribution § 75.800-4 Testing, examination, and maintenance of circuit breakers... adjustment of all circuit breakers protecting high-voltage circuits which enter any underground area of...

  18. 30 CFR 75.800-4 - Testing, examination, and maintenance of circuit breakers; record.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Underground High-Voltage Distribution § 75.800-4 Testing, examination, and maintenance of circuit breakers... adjustment of all circuit breakers protecting high-voltage circuits which enter any underground area of...

  19. 30 CFR 75.800-4 - Testing, examination, and maintenance of circuit breakers; record.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Underground High-Voltage Distribution § 75.800-4 Testing, examination, and maintenance of circuit breakers... adjustment of all circuit breakers protecting high-voltage circuits which enter any underground area of...

  20. 30 CFR 75.800-4 - Testing, examination, and maintenance of circuit breakers; record.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Underground High-Voltage Distribution § 75.800-4 Testing, examination, and maintenance of circuit breakers... adjustment of all circuit breakers protecting high-voltage circuits which enter any underground area of...

  1. Distribution of neurons immunoreactive for calcium-binding proteins varies across areas of cat primary somatosensory cortex.

    PubMed

    Schwark, H D; Li, J

    2000-03-15

    The primary somatosensory (SI) cortex in the cat contains four cytoarchitectonic areas that appear to contain separate body representations and have different functions. We tested whether functional differences among these areas are reflected in the densities of neurons containing each of three calcium-binding proteins: parvalbumin (PV), calbindin (CB), and calretinin (CR). Colocalization experiments revealed that CR was localized in a population of neurons distinct from those containing PV or CB. The general laminar distributions of the three calcium-binding proteins were similar to those described in other species and cortical areas, but there were significant density differences in layers II and III across SI. The density of PV-immunoreactive neurons was higher in areas 3b and 1 than in areas 3a and 2. CB-immunoreactive neurons were found in higher densities in anterior SI than in posterior SI, and the pattern of CR-immunoreactive neurons was reciprocal to that of CB, with significantly higher densities in posterior regions of SI. Since the firing characteristics of nonpyramidal neurons appear to be related to their calcium-binding protein content, differences in regional distributions of these neurons in layers II and III may contribute to functional differences between the cytoarchitectonic areas of SI cortex.

  2. Influenza and pneumococcal vaccine distribution and use in primary care and hospital settings in Scotland: coverage, practice and policies.

    PubMed Central

    Kyaw, M. H.; Wayne, B.; Chalmers, J.; Jones, I. G.; Campbell, H.

    2002-01-01

    A survey of the coverage, distribution and the factors associated with use of influenza and pneumococcal vaccines among general practitioners (GPs) in primary care and in hospital settings was carried out in 53 general practices in Scotland taking part in the 'Continuous Morbidity Recording' (CMR) programme. The annual vaccine distribution increased substantially among 53 general practices from 1993 to 1999 and in Scotland as a whole from 1984 to 1999. From the questionnaire, overall coverage was 43% (95% CI 38-48) for influenza vaccine in the 2000-1 season and 13% (95% CI 9-16) for pneumococcal vaccine in the last 5 year period, in high-risk patients recommended for these vaccines by the Department of Health (DoH). Influenza vaccine coverage was highest in the elderly (65 years of age and above) at 62% (95% CI 59-74). Although pneumococcal vaccination is not currently recommended for all elderly, coverage of this vaccine was also higher in this group (22%, 95% CI 16-29). In the majority of patients (influenza vaccine, 98% and pneumococcal vaccine, 94%), vaccination was carried out in general practice. Only 2% of patients had received pneumococcal vaccination in a hospital setting. The level of influenza and pneumococcal vaccination varied with the level of deprivation. Most GPs considered that the responsibility for influenza and pneumococcal vaccination lay with them. Forty-five percent of GPs reported having a written policy with set target for influenza vaccination and 11% for pneumococcal vaccination. PMID:12113489

  3. [THE DISTRIBUTION OF CORTICO-THALAMIC PROJECTIONS OF DIFFERENT OF DIFFERENT SOMATOTOPIC REPRESENTATIONS OF PRIMARY MOTOR AND SENSORY CORTEX].

    PubMed

    Ipekchyan, N M; Badalyan, S A

    2016-01-01

    The peculiarities of localization and distribution of cortico-thalamic efferents of different somatotopical representations of primary motor (MI) and sensory (SI) cortex were studied in cat brain. MI efferent fibers (4y, 6ab areas) preferentially projected to ventral posterolateral and medial (VPL, VPM), ventrolateral (VL), and reticular (R) nuclei, localized in rostral part of the thalamus (T), as opposed to SI (areas 1, 2, 3a, 3b), which projected preferentially to caudal part of T, VPL, VPM and R nuclei. Latero-medial organization of cortico-thalamic connections was demonstrated, with predominant localization of cortical representation of hindlimbs in the lateral part of VPL, of forelimbs--in the medial part of VPL, of face and head--also in VM and VPM. Quantitative analysis of the distribution of corticothalamic efferents of different somatotopical representations of MI has demonstrated the most extensive, massive connections with T nuclei (VPL, VL, R) of the motor representation of forelimb, followed by the representation of hindlimb, trunk and, finally, the minimal projection of the representation of face and head. As opposed to motor representation of the forelimb and also of the face and head, with uniform distribution of fibers in VPL, VL and R, the number of efferents of motor representation of hindlimb, passing in VL, was almost 2.5 time lower than in VPL and R, whereas the representation of trunk had the predominant projection to VL. Dominant cortico-thalamic connection suggests greater involvement of T nuclei studied in the realization of functional specialization of certain somatotopical representations of MI. PMID:27487657

  4. Algal pigment distribution and primary production in the eastern Mediterranean as derived from coastal zone color scanner observations

    NASA Astrophysics Data System (ADS)

    Antoine, David; Morel, André; André, Jean-Michel

    1995-08-01

    About 300 coastal zone color scanner (CZCS) scenes, gathered over the eastern Mediterranean basin mostly during the years 1979-1981, have been processed from level 1 by using improved pixel-by-pixel procedures for the atmospheric correction and pigment retrieval. The seasonal evolution of the upper ocean pigment concentration is described and analyzed within the whole basin and its subbasins. From the chlorophyll concentration in the top layer, and by using statistical relationships, the depth-integrated pigment content is estimated and used in conjunction with a light-photosynthesis model to estimate the carbon fixation. The model relies on a set of physiological parameters, selected after the validation of the light-photosynthesis model and not on locally measured parameters. Additional information needed in the modeling are the photosynthetically available radiation (computed from astronomic and atmospheric parameters, combined with a cloud climatology), sea temperature and mixed-layer depth (taken from Levitus (1982)). Actually, the model is used to generate look-up tables in such a way that all possible situations (concerning available radiation, chlorophyll concentration, and temperature) are covered. The appropriate situation associated with any pixel is selected from these tables to generate primary production maps. Despite a relatively good spatial coverage, studying the interannual variability of the pigment distribution and primary production appeared to be impossible. Therefore 12 "climatological" monthly chlorophyll maps have been produced by merging the data corresponding to several years. The carbon fixation rates in each of the subbasins have been computed on a monthly basis, and annual mean values derived thereafter. The primary production values are compared with sparse field determinations. They are also compared with those previously derived for the Western basin, also by using CZCS data (Morel and André, 1991). When put together, these

  5. Hidden circuits and argumentation

    NASA Astrophysics Data System (ADS)

    Leinonen, Risto; Kesonen, Mikko H. P.; Hirvonen, Pekka E.

    2016-11-01

    Despite the relevance of DC circuits in everyday life and schools, they have been shown to cause numerous learning difficulties at various school levels. In the course of this article, we present a flexible method for teaching DC circuits at lower secondary level. The method is labelled as hidden circuits, and the essential idea underlying hidden circuits is in hiding the actual wiring of DC circuits, but to make their behaviour evident for pupils. Pupils are expected to find out the wiring of the circuit which should enhance their learning of DC circuits. We present two possible ways to utilise hidden circuits in a classroom. First, they can be used to test and enhance pupils’ conceptual understanding when pupils are expected to find out which one of the offered circuit diagram options corresponds to the actual circuit shown. This method aims to get pupils to evaluate the circuits holistically rather than locally, and as a part of that aim this method highlights any learning difficulties of pupils. Second, hidden circuits can be used to enhance pupils’ argumentation skills with the aid of argumentation sheet that illustrates the main elements of an argument. Based on the findings from our co-operating teachers and our own experiences, hidden circuits offer a flexible and motivating way to supplement teaching of DC circuits.

  6. PAD-MAC: primary user activity-aware distributed MAC for multi-channel cognitive radio networks.

    PubMed

    Ali, Amjad; Piran, Md Jalil; Kim, Hansoo; Yun, Jihyeok; Suh, Doug Young

    2015-01-01

    Cognitive radio (CR) has emerged as a promising technology to solve problems related to spectrum scarcity and provides a ubiquitous wireless access environment. CR-enabled secondary users (SUs) exploit spectrum white spaces opportunistically and immediately vacate the acquired licensed channels as primary users (PUs) arrive. Accessing the licensed channels without the prior knowledge of PU traffic patterns causes severe throughput degradation due to excessive channel switching and PU-to-SU collisions. Therefore, it is significantly important to design a PU activity-aware medium access control (MAC) protocol for cognitive radio networks (CRNs). In this paper, we first propose a licensed channel usage pattern identification scheme, based on a two-state Markov model, and then estimate the future idle slots using previous observations of the channels. Furthermore, based on these past observations, we compute the rank of each available licensed channel that gives SU transmission success assessment during the estimated idle slot. Secondly, we propose a PU activity-aware distributed MAC (PAD-MAC) protocol for heterogeneous multi-channel CRNs that selects the best channel for each SU to enhance its throughput. PAD-MAC controls SU activities by allowing them to exploit the licensed channels only for the duration of estimated idle slots and enables predictive and fast channel switching. To evaluate the performance of the proposed PAD-MAC, we compare it with the distributed QoS-aware MAC (QC-MAC) and listen-before-talk MAC schemes. Extensive numerical results show the significant improvements of the PAD-MAC in terms of the SU throughput, SU channel switching rate and PU-to-SU collision rate. PMID:25831084

  7. PAD-MAC: Primary User Activity-Aware Distributed MAC for Multi-Channel Cognitive Radio Networks

    PubMed Central

    Ali, Amjad; Piran, Md. Jalil; Kim, Hansoo; Yun, Jihyeok; Suh, Doug Young

    2015-01-01

    Cognitive radio (CR) has emerged as a promising technology to solve problems related to spectrum scarcity and provides a ubiquitous wireless access environment. CR-enabled secondary users (SUs) exploit spectrum white spaces opportunistically and immediately vacate the acquired licensed channels as primary users (PUs) arrive. Accessing the licensed channels without the prior knowledge of PU traffic patterns causes severe throughput degradation due to excessive channel switching and PU-to-SU collisions. Therefore, it is significantly important to design a PU activity-aware medium access control (MAC) protocol for cognitive radio networks (CRNs). In this paper, we first propose a licensed channel usage pattern identification scheme, based on a two-state Markov model, and then estimate the future idle slots using previous observations of the channels. Furthermore, based on these past observations, we compute the rank of each available licensed channel that gives SU transmission success assessment during the estimated idle slot. Secondly, we propose a PU activity-aware distributed MAC (PAD-MAC) protocol for heterogeneous multi-channel CRNs that selects the best channel for each SU to enhance its throughput. PAD-MAC controls SU activities by allowing them to exploit the licensed channels only for the duration of estimated idle slots and enables predictive and fast channel switching. To evaluate the performance of the proposed PAD-MAC, we compare it with the distributed QoS-aware MAC (QC-MAC) and listen-before-talk MAC schemes. Extensive numerical results show the significant improvements of the PAD-MAC in terms of the SU throughput, SU channel switching rate and PU-to-SU collision rate. PMID:25831084

  8. PAD-MAC: primary user activity-aware distributed MAC for multi-channel cognitive radio networks.

    PubMed

    Ali, Amjad; Piran, Md Jalil; Kim, Hansoo; Yun, Jihyeok; Suh, Doug Young

    2015-03-30

    Cognitive radio (CR) has emerged as a promising technology to solve problems related to spectrum scarcity and provides a ubiquitous wireless access environment. CR-enabled secondary users (SUs) exploit spectrum white spaces opportunistically and immediately vacate the acquired licensed channels as primary users (PUs) arrive. Accessing the licensed channels without the prior knowledge of PU traffic patterns causes severe throughput degradation due to excessive channel switching and PU-to-SU collisions. Therefore, it is significantly important to design a PU activity-aware medium access control (MAC) protocol for cognitive radio networks (CRNs). In this paper, we first propose a licensed channel usage pattern identification scheme, based on a two-state Markov model, and then estimate the future idle slots using previous observations of the channels. Furthermore, based on these past observations, we compute the rank of each available licensed channel that gives SU transmission success assessment during the estimated idle slot. Secondly, we propose a PU activity-aware distributed MAC (PAD-MAC) protocol for heterogeneous multi-channel CRNs that selects the best channel for each SU to enhance its throughput. PAD-MAC controls SU activities by allowing them to exploit the licensed channels only for the duration of estimated idle slots and enables predictive and fast channel switching. To evaluate the performance of the proposed PAD-MAC, we compare it with the distributed QoS-aware MAC (QC-MAC) and listen-before-talk MAC schemes. Extensive numerical results show the significant improvements of the PAD-MAC in terms of the SU throughput, SU channel switching rate and PU-to-SU collision rate.

  9. Noise in biological circuits

    SciTech Connect

    Simpson, Michael L; Allen, Michael S.; Cox, Chris D.; Dar, Roy D.; Karig, David K; McCollum, James M.; Cooke, John F

    2009-01-01

    Noise biology focuses on the sources, processing, and biological consequences of the inherent stochastic fluctuations in molecular transitions or interactions that control cellular behavior. These fluctuations are especially pronounced in small systems where the magnitudes of the fluctuations approach or exceed the mean value of the molecular population. Noise biology is an essential component of nanomedicine where the communication of information is across a boundary that separates small synthetic and biological systems that are bound by their size to reside in environments of large fluctuations. Here we review the fundamentals of the computational, analytical, and experimental approaches to noise biology. We review results that show that the competition between the benefits of low noise and those of low population has resulted in the evolution of genetic system architectures that produce an uneven distribution of stochasticity across the molecular components of cells and, in some cases, use noise to drive biological function. We review the exact and approximate approaches to gene circuit noise analysis and simulation, and reviewmany of the key experimental results obtained using flow cytometry and time-lapse fluorescent microscopy. In addition, we consider the probative value of noise with a discussion of using measured noise properties to elucidate the structure and function of the underlying gene circuit. We conclude with a discussion of the frontiers of and significant future challenges for noise biology.

  10. [Profile distribution of soil aggregates organic carbon in primary forests in Karst cluster-peak depression region].

    PubMed

    Lu, Ling-Xiao; Song, Tong-Qing; Peng, Wan-Xia; Zeng, Fu-Ping; Wang, Ke-Lin; Xu, Yun-Lei; Yu, Zi; Liu, Yan

    2012-05-01

    Soil profiles were collected from three primary forests (Itoa orientalis, Platycladus orientalis, and Radermachera sinica) in Karst cluster-peak depression region to study the composition of soil aggregates, their organic carbon contents, and the profile distribution of the organic carbon. In the three forests, >2 mm soil aggregates were dominant, occupying about 76% of the total. The content of soil total organic carbon ranged from 12.73 to 68.66 g x kg(-1), with a significant difference among the forests. The organic carbon content in <1 mm soil aggregates was slightly higher than that in >2 mm soil aggregates, but most of soil organic carbon was stored in the soil aggregates with greater particle sizes. About 70% of soil organic carbon came from >2 mm soil aggregates. There was a significant positive relationship between the contents of 2-5 and 5-8 mm soil aggregates and the content of soil organic carbon. To increase the contents of 2-8 mm soil aggregates could effectively improve the soil carbon sequestration in Karst region. In Itoa orientalis forest, 2-8 mm soil aggregates accounted for 46% of the total, and the content of soil total organic carbon reached to 37.62 g x kg(-1), which implied that Itoa orientalis could be the suitable tree species for the ecological restoration in Karst region.

  11. 30 CFR 57.6402 - Deenergized circuits near detonators.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Deenergized circuits near detonators. 57.6402... Electric Blasting-Surface and Underground § 57.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized....

  12. 30 CFR 57.6402 - Deenergized circuits near detonators.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Deenergized circuits near detonators. 57.6402... Electric Blasting-Surface and Underground § 57.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized....

  13. 30 CFR 57.6402 - Deenergized circuits near detonators.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Deenergized circuits near detonators. 57.6402... Electric Blasting-Surface and Underground § 57.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized....

  14. 30 CFR 57.6402 - Deenergized circuits near detonators.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Deenergized circuits near detonators. 57.6402... Electric Blasting-Surface and Underground § 57.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized....

  15. 30 CFR 57.6402 - Deenergized circuits near detonators.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Deenergized circuits near detonators. 57.6402... Electric Blasting-Surface and Underground § 57.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized....

  16. Charge regulation circuit

    DOEpatents

    Ball, Don G.

    1992-01-01

    A charge regulation circuit provides regulation of an unregulated voltage supply in the range of 0.01%. The charge regulation circuit is utilized in a preferred embodiment in providing regulated voltage for controlling the operation of a laser.

  17. Electrical Circuits and Water Analogies

    ERIC Educational Resources Information Center

    Smith, Frederick A.; Wilson, Jerry D.

    1974-01-01

    Briefly describes water analogies for electrical circuits and presents plans for the construction of apparatus to demonstrate these analogies. Demonstrations include series circuits, parallel circuits, and capacitors. (GS)

  18. Piezoelectric drive circuit

    DOEpatents

    Treu, C.A. Jr.

    1999-08-31

    A piezoelectric motor drive circuit is provided which utilizes the piezoelectric elements as oscillators and a Meacham half-bridge approach to develop feedback from the motor ground circuit to produce a signal to drive amplifiers to power the motor. The circuit automatically compensates for shifts in harmonic frequency of the piezoelectric elements due to pressure and temperature changes. 7 figs.

  19. Piezoelectric drive circuit

    DOEpatents

    Treu, Jr., Charles A.

    1999-08-31

    A piezoelectric motor drive circuit is provided which utilizes the piezoelectric elements as oscillators and a Meacham half-bridge approach to develop feedback from the motor ground circuit to produce a signal to drive amplifiers to power the motor. The circuit automatically compensates for shifts in harmonic frequency of the piezoelectric elements due to pressure and temperature changes.

  20. CIRCUITS FOR CURRENT MEASUREMENTS

    DOEpatents

    Cox, R.J.

    1958-11-01

    Circuits are presented for measurement of a logarithmic scale of current flowing in a high impedance. In one form of the invention the disclosed circuit is in combination with an ionization chamber to measure lonization current. The particular circuit arrangement lncludes a vacuum tube having at least one grid, an ionization chamber connected in series with a high voltage source and the grid of the vacuum tube, and a d-c amplifier feedback circuit. As the ionization chamber current passes between the grid and cathode of the tube, the feedback circuit acts to stabilize the anode current, and the feedback voltage is a measure of the logaritbm of the ionization current.

  1. Depth-optimized reversible circuit synthesis

    NASA Astrophysics Data System (ADS)

    Arabzadeh, Mona; Saheb Zamani, Morteza; Sedighi, Mehdi; Saeedi, Mehdi

    2013-04-01

    In this paper, simultaneous reduction of circuit depth and synthesis cost of reversible circuits in quantum technologies with limited interaction is addressed. We developed a cycle-based synthesis algorithm which uses negative controls and limited distance between gate lines. To improve circuit depth, a new parallel structure is introduced in which before synthesis a set of disjoint cycles are extracted from the input specification and distributed into some subsets. The cycles of each subset are synthesized independently on different sets of ancillae. Accordingly, each disjoint set can be synthesized by different synthesis methods. Our analysis shows that the best worst-case synthesis cost of reversible circuits in the linear nearest neighbor architecture is improved by the proposed approach. Our experimental results reveal the effectiveness of the proposed approach to reduce cost and circuit depth for several benchmarks.

  2. Single event upset protection circuit and method

    DOEpatents

    Wallner, John; Gorder, Michael

    2016-03-22

    An SEU protection circuit comprises first and second storage means for receiving primary and redundant versions, respectively, of an n-bit wide data value that is to be corrected in case of an SEU occurrence; the correction circuit requires that the data value be a 1-hot encoded value. A parity engine performs a parity operation on the n bits of the primary data value. A multiplexer receives the primary and redundant data values and the parity engine output at respective inputs, and is arranged to pass the primary data value to an output when the parity engine output indicates `odd` parity, and to pass the redundant data value to the output when the parity engine output indicates `even` parity. The primary and redundant data values are suitably state variables, and the parity engine is preferably an n-bit wide XOR or XNOR gate.

  3. [Distribution features of chlorophyll a and primary productivity in high frequency area of red tide in East China Sea during spring].

    PubMed

    Zhou, Weihua; Huo, Wenyi; Yuan, Xiangcheng; Yin, Kedong

    2003-07-01

    The distributions of chlorophyll a and primary productivity were determined during April to May 2002 in the East China Sea. The results showed that the average concentration of chlorophyll a was 1.086 mg.m-3 at surface layer, and that nano- and pico-phytoplankton (< 20 microns) dominated the phytoplankton biomass in this sea region during Spring (up to 64% of total chlorophyll a content). Ultra-phytoplankton (< 5 microns) consisted 27% of total phytoplankton biomass. Nutrients and feeding pressure of zooplankton affected the distribution of chlorophyll a and its size-fractionation. The average primary productivity was 10.091 mg.m-3.h-1, while that of red tide tracking stations R-03, RL-01 and RG-01 was 399.984 mg.m-3.h-1. Light and nutrients were the main factors affecting the distributions of chlorophyll a and primary productivity. The station DC-11 had a high concentration of phytoplankton biomass. The surface layer concentration of chlorophyll a and primary productivity were up to 9,082 mg.m-3 and 128,79 mg.m-3.h-1, respectively, but the color of the seawater was normal.

  4. Modeling the transport of nitrogen in an NPP-2006 reactor circuit

    NASA Astrophysics Data System (ADS)

    Stepanov, O. E.; Galkin, I. Yu.; Sledkov, R. M.; Melekh, S. S.; Strebnev, N. A.

    2016-07-01

    Efficient radiation protection of the public and personnel requires detecting an accident-initiating event quickly. Specifically, if a heat-exchange tube in a steam generator is ruptured, the 16N radioactive nitrogen isotope, which contributes to a sharp increase in the steam activity before the turbine, may serve as the signaling component. This isotope is produced in the core coolant and is transported along the circulation circuit. The aim of the present study was to model the transport of 16N in the primary and the secondary circuits of a VVER-1000 reactor facility (RF) under nominal operation conditions. KORSAR/GP and RELAP5/Mod.3.2 codes were used to perform the calculations. Computational models incorporating the major components of the primary and the secondary circuits of an NPP-2006 RF were constructed. These computational models were subjected to cross-verification, and the calculation results were compared to the experimental data on the distribution of the void fraction over the steam generator height. The models were proven to be valid. It was found that the time of nitrogen transport from the core to the heat-exchange tube leak was no longer than 1 s under RF operation at a power level of 100% N nom with all primary circuit pumps activated. The time of nitrogen transport from the leak to the γ-radiation detection unit under the same operating conditions was no longer than 9 s, and the nitrogen concentration in steam was no less than 1.4% (by mass) of its concentration at the reactor outlet. These values were obtained using conservative approaches to estimating the leak flow and the transport time, but the radioactive decay of nitrogen was not taken into account. Further research concerned with the calculation of thermohydraulic processes should be focused on modeling the transport of nitrogen under RF operation with some primary circuit pumps deactivated.

  5. Red Blood Cell Distribution Width to Platelet Ratio is Related to Histologic Severity of Primary Biliary Cirrhosis

    PubMed Central

    Wang, Huan; Xu, Hongqin; Wang, Xiaomei; Wu, Ruihong; Gao, Xiuzhu; Jin, Qinglong; Niu, Junqi

    2016-01-01

    Abstract We aimed to investigate whether red blood cell distribution width (RDW) and RDW to platelet ratio (RPR) were related to the histologic severity of primary biliary cirrhosis (PBC). Seventy-three treatment-naïve PBC patients who had undergone a liver biopsy between January 2010 and January 2015 were enrolled in our study. The patients’ histological stages were based on the classifications of Ludwig and Scheuer. The patients were divided into early stage (Stage I) and advanced stage (Stage II, III, and IV) hepatic fibrosis according to their histological stage. All common patient demographics, clinical characteristics, hematological parameters, liver biochemistry, and antimitochondrial M2 antibody levels (AMA-M2) were retrospectively analyzed, and RDW, RPR, aspartate aminotransferase-to-platelet ratio index (APRI), and fibrosis index based on the 4 factors (FIB-4) were calculated. A total of 28 (38.4%) patients had early stage PBC, whereas 45 (62.6%) were classified as advanced stage. Regarding age, no significant differences between the early and advanced stages were observed. Patients with advanced stage PBC had significantly higher RDW (13.6 vs 14.4; P = 0.019), conjugated bilirubin (10.1 vs 23.4; P = 0.029), and significantly lower cholinesterase (7901.1 vs 6060.8; P = 0.001) and platelets (212.6 vs 167.0; P = 0.006). However, no significant differences (P > 0.05) in other routine parameters previously evaluated in PBC, including aspartate aminotransferase (AST) and mean platelet volume, were found between the groups. The sensitivity and specificity of RDW were 33.3% and 92.9%, respectively, and the area under the receiver-operating characteristic curve (AUROC) was 0.66. However, the sensitivity and specificity of RPR were 46.7% and 96.4%, respectively, and the corresponding AUROC was 0.74 (P < 0.001). Hence, compared with preexisting indicators, RPR showed a higher AUROC than APRI (0.648; P = 0.035) and FIB-4 (0.682; P

  6. Source circuit design considerations

    NASA Technical Reports Server (NTRS)

    Noel, G. T.

    1983-01-01

    The cost of several circuit configurations for large (5MW) array fields were investigated to assess the relative costs of high and low voltage configurations. Three source circuit NOC voltages were evaluated: 400V (ungrounded), 800V (+ or 400V center grounded), and 2000V (+ or - 1000V center grounded). Four source circuit configurations were considered for each of the three NOC voltages. The configurations correspond to source circuit currents of 15, 30, 45, and 60 amperes, respectively. Conceptual layouts for 5MW building blocks for each of the above configurations were developed. The designs were optimized to minimize BOS electrical and structural costs. Only the BOS electrical costs were evaluated. The designs were broken down into the following elements for cost: (1) basic source circuit intermodule wiring, bypass diodes and associated hardware, source circuit to J-Box wiring, etc; (2) J-Box blocking diodes, varistors, heat sinks, and housing; (3) disconnects source circuit disconnects, fuses, and housing; (4) bus cabling J-Box to PCU interface wiring, and trenching; (5) interface bus bar, group disconnects, and fuses; and (6) fault detection shunts, signal wire, electronics, and alarm. It is concluded that high voltage low current circuits are not economical, at higher currents high and low voltage circuit costs approach each other, high voltage circuits are not likely to offer near term advantage, and development work/manufacturer stimulation is needed to develop low cost high voltage hardware.

  7. Transverse-Type Short-Circuited Thermoelements

    NASA Astrophysics Data System (ADS)

    Anatychuk, L. I.; Kobylyansky, R. R.

    2012-06-01

    This work reports on the results of theoretical and experimental research of short-circuited thermoelements (SCTE). Computer simulation was used to obtain the electric potential, current, and temperature distributions in the bulk of thermoelements. Computer optimization of such a thermoelement design was carried out to achieve maximum transverse thermoelectromotive force (thermoEMF) and efficiency. Experimental studies of the short-circuited thermoelements were pursued. Bi-Te alloys were used as the thermoelectric material. It was established that, among the transverse-type thermoelements, double short-circuited thermoelements achieve the highest values of transverse thermoEMF and efficiency.

  8. Chain Of Test Contacts For Integrated Circuits

    NASA Technical Reports Server (NTRS)

    Lieneweg, Udo

    1989-01-01

    Test structure forms chain of "cross" contacts fabricated together with large-scale integrated circuits. If necessary, number of such chains incorporated at suitable locations in integrated-circuit wafer for determination of fabrication yield of contacts. In new structure, resistances of individual contacts determined: In addition to making it possible to identify local defects, enables generation of statistical distributions of contact resistances for prediction of "parametric" contact yield of fabrication process.

  9. Brain Circuits Encoding Reward from Pain Relief

    PubMed Central

    Navratilova, Edita; Atcherley, Christopher; Porreca, Frank

    2015-01-01

    Relief from pain in humans is rewarding and pleasurable. Primary rewards, or reward predictive cues, are encoded in brain reward/motivational circuits. While considerable advances have been made in our understanding of reward circuits underlying positive reinforcement, less is known about the circuits underlying the hedonic and reinforcing actions of pain relief. We review findings from electrophysiological, neuroimaging and behavioral studies supporting the concept that the rewarding effect of pain relief requires opioid signaling in the anterior cingulate cortex, activation of midbrain dopamine neurons and release of dopamine in the nucleus accumbens. Understanding of circuits that govern the reward of pain relief may allow the discovery of more effective and satisfying therapies for patients with acute and chronic pain. PMID:26603560

  10. Closed circuit anesthesia: preservation of the environment.

    PubMed

    Novelli, G P; Bonetti, L

    1995-01-01

    Closed circuit anesthesia must be considered as a primary contributor enabling to reduce the damaging effect of anesthetic agents on the environment. Halogenated vapors and nitrous oxide damage both the macro-environment, i.e. the earth's atmosphere layer and the micro-environment, i.e. the operating room ambience. As nitrous oxide is one of the most toxic agents, and as pure oxygen is harmful to the lungs, a technique of closed circuit anesthesia has been developed which employs oxygen/air (0.35:0.35 l/min) as a carrier of isoflurane. The safety of this oxygen-air technique of closed circuit anesthesia has been demonstrated by the greater stability of oxygen concentrations in the circuit in comparison to the more extensively used oxygen-nitrous oxide technique.

  11. Regenerative feedback resonant circuit

    DOEpatents

    Jones, A. Mark; Kelly, James F.; McCloy, John S.; McMakin, Douglas L.

    2014-09-02

    A regenerative feedback resonant circuit for measuring a transient response in a loop is disclosed. The circuit includes an amplifier for generating a signal in the loop. The circuit further includes a resonator having a resonant cavity and a material located within the cavity. The signal sent into the resonator produces a resonant frequency. A variation of the resonant frequency due to perturbations in electromagnetic properties of the material is measured.

  12. Remote reset circuit

    DOEpatents

    Gritzo, Russell E.

    1987-01-01

    A remote reset circuit acts as a stand-alone monitor and controller by clocking in each character sent by a terminal to a computer and comparing it to a given reference character. When a match occurs, the remote reset circuit activates the system's hardware reset line. The remote reset circuit is hardware based centered around monostable multivibrators and is unaffected by system crashes, partial serial transmissions, or power supply transients.

  13. Remote reset circuit

    DOEpatents

    Gritzo, R.E.

    1985-09-12

    A remote reset circuit acts as a stand-along monitor and controller by clocking in each character sent by a terminal to a computer and comparing it to a given reference character. When a match occurs, the remote reset circuit activates the system's hardware reset line. The remote reset circuit is hardware based centered around monostable multivibrators and is unaffected by system crashes, partial serial transmissions, or power supply transients. 4 figs.

  14. Fast Overcurrent Tripping Circuit

    NASA Technical Reports Server (NTRS)

    Sullender, Craig C.; Davies, Bryan L.; Osborn, Stephen H.

    1993-01-01

    Fast overcurrent tripping circuit designed for incorporation into power metal oxide/semiconductor field-effect transistor (MOSFET) switching circuit. Serves as fast electronic circuit breaker by sensing voltage across MOSFET's during conduction and switching MOSFET's off within 1 microsecond after voltage exceeds reference value corresponding to tripping current. Acts more quickly than Hall-effect current sensor and, in comparison with shunt current-measuring circuits, smaller and consumes less power. Also ignores initial transient overcurrents during first 5 microseconds of switching cycle.

  15. Input clustering in the normal and learned circuits of adult barn owls

    PubMed Central

    McBride, Thomas J; DeBello, William M

    2015-01-01

    Experience-dependent formation of synaptic input clusters can occur in juvenile brains. Whether this also occurs in adults is largely unknown. We previously reconstructed the normal and learned circuits of prism-adapted barn owls and found that changes in clustering of axo-dendritic contacts (putative synapses) predicted functional circuit strength. Here we asked whether comparable changes occurred in normal and prism-removed adults. Across all anatomical zones, no systematic differences in the primary metrics for within-branch or between-branch clustering were observed: 95–99% of contacts resided within clusters (<10–20 microns from nearest neighbor) regardless of circuit strength. Bouton volumes, a proxy measure of synaptic strength, were on average larger in the functionally strong zones, indicating that changes in synaptic efficacy contributed to the differences in circuit strength. Bootstrap analysis showed that the distribution of inter-contact distances strongly deviated from random not in the functionally strong zones but in those that had been strong during the sensitive period (60d ~ 250d), indicating that clusters formed early in life were preserved regardless of current value. While cluster formation in juveniles appeared to require the production of new synapses, cluster formation in adults did not. In total, these results support a model in which high cluster dynamics in juveniles sculpt a potential connectivity map that is refined in adulthood. We propose that preservation of clusters in functionally weak adult circuits provides a storage mechanism for disused but potentially useful pathways. PMID:25701706

  16. The Distribution of Primary and Secondary School Places between Provinces in Papua New Guinea from 1972 to 1978.

    ERIC Educational Resources Information Center

    Sheret, M. A.

    1979-01-01

    Lorenz curves and Gini coefficients of concentration are used to measure the extent to which school places are uniformly distributed between provinces in Papua New Guinea. For the period studied, the distribution has become significantly more uniform, in keeping with the nation's planning objectives for more equal educational opportunity.…

  17. Circuit Controls Turn-On Current

    NASA Technical Reports Server (NTRS)

    Holmes, K. G.

    1972-01-01

    Single choke used in primary circuit with diode arrangement, maintaining dc current flow through choke and setting up a unidirectional magnetic field, limits turn-on current of transformer-rectifier power supply. Technique reduces number and weight of components and minimizes effect of initial inrush surge current on source.

  18. A Virtual Circuits Lab

    ERIC Educational Resources Information Center

    Vick, Matthew E.

    2010-01-01

    The University of Colorado's Physics Education Technology (PhET) website offers free, high-quality simulations of many physics experiments that can be used in the classroom. The Circuit Construction Kit, for example, allows students to safely and constructively play with circuit components while learning the mathematics behind many circuit…

  19. Genetic circuit design automation.

    PubMed

    Nielsen, Alec A K; Der, Bryan S; Shin, Jonghyeon; Vaidyanathan, Prashant; Paralanov, Vanya; Strychalski, Elizabeth A; Ross, David; Densmore, Douglas; Voigt, Christopher A

    2016-04-01

    Computation can be performed in living cells by DNA-encoded circuits that process sensory information and control biological functions. Their construction is time-intensive, requiring manual part assembly and balancing of regulator expression. We describe a design environment, Cello, in which a user writes Verilog code that is automatically transformed into a DNA sequence. Algorithms build a circuit diagram, assign and connect gates, and simulate performance. Reliable circuit design requires the insulation of gates from genetic context, so that they function identically when used in different circuits. We used Cello to design 60 circuits forEscherichia coli(880,000 base pairs of DNA), for which each DNA sequence was built as predicted by the software with no additional tuning. Of these, 45 circuits performed correctly in every output state (up to 10 regulators and 55 parts), and across all circuits 92% of the output states functioned as predicted. Design automation simplifies the incorporation of genetic circuits into biotechnology projects that require decision-making, control, sensing, or spatial organization.

  20. Computer circuit card puller

    NASA Technical Reports Server (NTRS)

    Sawyer, R. V.; Szuwalski, B. (Inventor)

    1981-01-01

    The invention generally relates to hand tools, and more particularly to an improved device for facilitating removal of printed circuit cards from a card rack characterized by longitudinal side rails arranged in a mutually spaced parallelism and a plurality of printed circuit cards extended between the rails of the rack.

  1. Genetic circuit design automation.

    PubMed

    Nielsen, Alec A K; Der, Bryan S; Shin, Jonghyeon; Vaidyanathan, Prashant; Paralanov, Vanya; Strychalski, Elizabeth A; Ross, David; Densmore, Douglas; Voigt, Christopher A

    2016-04-01

    Computation can be performed in living cells by DNA-encoded circuits that process sensory information and control biological functions. Their construction is time-intensive, requiring manual part assembly and balancing of regulator expression. We describe a design environment, Cello, in which a user writes Verilog code that is automatically transformed into a DNA sequence. Algorithms build a circuit diagram, assign and connect gates, and simulate performance. Reliable circuit design requires the insulation of gates from genetic context, so that they function identically when used in different circuits. We used Cello to design 60 circuits forEscherichia coli(880,000 base pairs of DNA), for which each DNA sequence was built as predicted by the software with no additional tuning. Of these, 45 circuits performed correctly in every output state (up to 10 regulators and 55 parts), and across all circuits 92% of the output states functioned as predicted. Design automation simplifies the incorporation of genetic circuits into biotechnology projects that require decision-making, control, sensing, or spatial organization. PMID:27034378

  2. Completing a Simple Circuit.

    ERIC Educational Resources Information Center

    Slater, Timothy F.; Adams, Jeffrey P.; Brown, Thomas R.

    2000-01-01

    Students have problems successfully arranging an electric circuit to make the bulb produce light. Investigates the percentage of students able to complete a circuit with a given apparatus, and the effects of prior experience on student success. Recommends hands-on activities at the elementary and secondary school levels. (Contains 14 references.)…

  3. Understanding Simple Circuits

    ERIC Educational Resources Information Center

    Mant, Jenny; Wilson, Helen

    2007-01-01

    Many envisage electricity as the "power" to "do things." They know that electricity needs "circuits" and that something is "flowing" in the circuits, but they are not sure what or why. Words such as "current" and "voltage" are part of electricity but their meaning, and the difference between them, is not always clear. In this article, the authors…

  4. Interconnections for fluidic circuits

    NASA Technical Reports Server (NTRS)

    Mangion, C.

    1972-01-01

    Circuit elements are grouped on functional basis in rectangular two-dimensional planar arrays or modules. Another interconnection method brings all connections out to module edge. For smaller fluidic circuits, manifold and interconnections are fabricated as single blocks. Advantages of methods are given.

  5. Liquid detection circuit

    DOEpatents

    Regan, Thomas O.

    1987-01-01

    Herein is a circuit which is capable of detecting the presence of liquids, especially cryogenic liquids, and whose sensor will not overheat in a vacuum. The circuit parameters, however, can be adjusted to work with any liquid over a wide range of temperatures.

  6. Discrete control of linear distributed systems with application to the deformable primary mirror of a large orbiting telescope. Ph.D. Thesis - Rhode Island Univ.

    NASA Technical Reports Server (NTRS)

    Creedon, J. F.

    1970-01-01

    The results are presented of a detailed study of the discrete control of linear distributed systems with specific application to the design of a practical controller for a plant representative of a telescope primary mirror for an orbiting astronomical observatory. The problem of controlling the distributed plant is treated by employing modal techniques to represent variations in the optical figure. Distortion of the mirror surface, which arises primarily from thermal gradients, is countered by actuators working against a backing structure to apply a corrective force distribution to the controlled surface. Each displacement actuator is in series with a spring attached to the mirror by means of a pad intentionally introduced to restrict the excitation of high-order modes. Control is exerted over a finite number of the most significant modes.

  7. Compensated gain control circuit for buck regulator command charge circuit

    DOEpatents

    Barrett, D.M.

    1996-11-05

    A buck regulator command charge circuit includes a compensated-gain control signal for compensating for changes in the component values in order to achieve optimal voltage regulation. The compensated-gain control circuit includes an automatic-gain control circuit for generating a variable-gain control signal. The automatic-gain control circuit is formed of a precision rectifier circuit, a filter network, an error amplifier, and an integrator circuit. 5 figs.

  8. Compensated gain control circuit for buck regulator command charge circuit

    DOEpatents

    Barrett, David M.

    1996-01-01

    A buck regulator command charge circuit includes a compensated-gain control signal for compensating for changes in the component values in order to achieve optimal voltage regulation. The compensated-gain control circuit includes an automatic-gain control circuit for generating a variable-gain control signal. The automatic-gain control circuit is formed of a precision rectifier circuit, a filter network, an error amplifier, and an integrator circuit.

  9. Spatial distribution and risk assessment of metals in dust based on samples from nursery and primary schools of Xi'an, China

    NASA Astrophysics Data System (ADS)

    Chen, Hao; Lu, Xinwei; Li, Loretta Y.

    2014-05-01

    The spatial distribution of metal (Cu, Pb, Zn, As, Ba, Co, Cr, Mn, Ni and V) concentrations in urban dust of Xi'an, China was determined using the geographical information system method on dust from nursery and primary schools. The health risk of these metals in campus dust to children was assessed based on the EPA heath risk model. The results indicate elevated metal concentrations, especially of Cu, Pb, Zn, Co, Cr and Ba, which are 1.5-10.2, 2.6-73.0, 2.1-26.5, 2.0-10.9, 1.2-10.2 and 1.1-10.4 times the background values of Shaanxi soil, respectively. Pb, Cr, Cu and Ba have similar distribution patterns. The hot-spot areas of Pb, Zn, Cu, Co, Cr and Ba are mainly associated with industrial activities and heavy traffic. Their spatial distributions in the Xi'an urban dust indicated that these metals mainly originate from vehicles and industrial activities. For As, Mn, Ni and V, natural factors are important in controlling their distributions. Health risk assessment shows that ingestion is the largest exposure route of metals in dust from nursery and primary schools to children. The mean hazard indices for non-cancer risk of all analyzed metals due to campus dust are within the safe range, while the maximum hazard indices of Pb, Cr and As are close to, or slightly higher than, safe levels. The cancer risks of As, Co, Cr and Ni to nursery and primary school children, considering only inhalation, are within the acceptable range.

  10. Approximate circuits for increased reliability

    DOEpatents

    Hamlet, Jason R.; Mayo, Jackson R.

    2015-12-22

    Embodiments of the invention describe a Boolean circuit having a voter circuit and a plurality of approximate circuits each based, at least in part, on a reference circuit. The approximate circuits are each to generate one or more output signals based on values of received input signals. The voter circuit is to receive the one or more output signals generated by each of the approximate circuits, and is to output one or more signals corresponding to a majority value of the received signals. At least some of the approximate circuits are to generate an output value different than the reference circuit for one or more input signal values; however, for each possible input signal value, the majority values of the one or more output signals generated by the approximate circuits and received by the voter circuit correspond to output signal result values of the reference circuit.

  11. Approximate circuits for increased reliability

    DOEpatents

    Hamlet, Jason R.; Mayo, Jackson R.

    2015-08-18

    Embodiments of the invention describe a Boolean circuit having a voter circuit and a plurality of approximate circuits each based, at least in part, on a reference circuit. The approximate circuits are each to generate one or more output signals based on values of received input signals. The voter circuit is to receive the one or more output signals generated by each of the approximate circuits, and is to output one or more signals corresponding to a majority value of the received signals. At least some of the approximate circuits are to generate an output value different than the reference circuit for one or more input signal values; however, for each possible input signal value, the majority values of the one or more output signals generated by the approximate circuits and received by the voter circuit correspond to output signal result values of the reference circuit.

  12. Sensor readout detector circuit

    DOEpatents

    Chu, D.D.; Thelen, D.C. Jr.

    1998-08-11

    A sensor readout detector circuit is disclosed that is capable of detecting sensor signals down to a few nanoamperes or less in a high (microampere) background noise level. The circuit operates at a very low standby power level and is triggerable by a sensor event signal that is above a predetermined threshold level. A plurality of sensor readout detector circuits can be formed on a substrate as an integrated circuit (IC). These circuits can operate to process data from an array of sensors in parallel, with only data from active sensors being processed for digitization and analysis. This allows the IC to operate at a low power level with a high data throughput for the active sensors. The circuit may be used with many different types of sensors, including photodetectors, capacitance sensors, chemically-sensitive sensors or combinations thereof to provide a capability for recording transient events or for recording data for a predetermined period of time following an event trigger. The sensor readout detector circuit has applications for portable or satellite-based sensor systems. 6 figs.

  13. Sensor readout detector circuit

    DOEpatents

    Chu, Dahlon D.; Thelen, Jr., Donald C.

    1998-01-01

    A sensor readout detector circuit is disclosed that is capable of detecting sensor signals down to a few nanoamperes or less in a high (microampere) background noise level. The circuit operates at a very low standby power level and is triggerable by a sensor event signal that is above a predetermined threshold level. A plurality of sensor readout detector circuits can be formed on a substrate as an integrated circuit (IC). These circuits can operate to process data from an array of sensors in parallel, with only data from active sensors being processed for digitization and analysis. This allows the IC to operate at a low power level with a high data throughput for the active sensors. The circuit may be used with many different types of sensors, including photodetectors, capacitance sensors, chemically-sensitive sensors or combinations thereof to provide a capability for recording transient events or for recording data for a predetermined period of time following an event trigger. The sensor readout detector circuit has applications for portable or satellite-based sensor systems.

  14. Polymorphic Electronic Circuits

    NASA Technical Reports Server (NTRS)

    Stoica, Adrian

    2004-01-01

    Polymorphic electronics is a nascent technological discipline that involves, among other things, designing the same circuit to perform different analog and/or digital functions under different conditions. For example, a circuit can be designed to function as an OR gate or an AND gate, depending on the temperature (see figure). Polymorphic electronics can also be considered a subset of polytronics, which is a broader technological discipline in which optical and possibly other information- processing systems could also be designed to perform multiple functions. Polytronics is an outgrowth of evolvable hardware (EHW). The basic concepts and some specific implementations of EHW were described in a number of previous NASA Tech Briefs articles. To recapitulate: The essence of EHW is to design, construct, and test a sequence of populations of circuits that function as incrementally better solutions of a given design problem through the selective, repetitive connection and/or disconnection of capacitors, transistors, amplifiers, inverters, and/or other circuit building blocks. The evolution is guided by a search-and-optimization algorithm (in particular, a genetic algorithm) that operates in the space of possible circuits to find a circuit that exhibits an acceptably close approximation of the desired functionality. The evolved circuits can be tested by computational simulation (in which case the evolution is said to be extrinsic), tested in real hardware (in which case the evolution is said to be intrinsic), or tested in random sequences of computational simulation and real hardware (in which case the evolution is said to be mixtrinsic).

  15. Gallium Arsenide Domino Circuit

    NASA Technical Reports Server (NTRS)

    Yang, Long; Long, Stephen I.

    1990-01-01

    Advantages include reduced power and high speed. Experimental gallium arsenide field-effect-transistor (FET) domino circuit replicated in large numbers for use in dynamic-logic systems. Name of circuit denotes mode of operation, which logic signals propagate from each stage to next when successive stages operated at slightly staggered clock cycles, in manner reminiscent of dominoes falling in a row. Building block of domino circuit includes input, inverter, and level-shifting substages. Combinational logic executed in input substage. During low half of clock cycle, result of logic operation transmitted to following stage.

  16. Monolithic microwave integrated circuits

    NASA Astrophysics Data System (ADS)

    Pucel, R. A.

    Monolithic microwave integrated circuits (MMICs), a new microwave technology which is expected to exert a profound influence on microwave circuit designs for future military systems as well as for the commercial and consumer markets, is discussed. The book contains an historical discussion followed by a comprehensive review presenting the current status in the field. The general topics of the volume are: design considerations, materials and processing considerations, monolithic circuit applications, and CAD, measurement, and packaging techniques. All phases of MMIC technology are covered, from design to testing.

  17. DIFFERENTIAL FAULT SENSING CIRCUIT

    DOEpatents

    Roberts, J.H.

    1961-09-01

    A differential fault sensing circuit is designed for detecting arcing in high-voltage vacuum tubes arranged in parallel. A circuit is provided which senses differences in voltages appearing between corresponding elements likely to fault. Sensitivity of the circuit is adjusted to some level above which arcing will cause detectable differences in voltage. For particular corresponding elements, a group of pulse transformers are connected in parallel with diodes connected across the secondaries thereof so that only voltage excursions are transmitted to a thyratron which is biased to the sensitivity level mentioned.

  18. Arrival time distributions of electrons in air showers with primary energies above 10 (18)eV observed at 900m above sea level

    NASA Technical Reports Server (NTRS)

    Kakimoto, F.; Tsuchimoto, I.; Enoki, T.; Suga, K.; Nishi, K.

    1985-01-01

    Detection of air showers with primary energies above 10 to the 19th power eV with sufficient statistics is extremely important in an astrophysical aspect related to the Greisen cut off and the origin of such high energy cosmic rays. Recently, a method is proposed to observe such giant air showers by measuring the arrival time distributions of air-shower particles at large core distances with a mini array. Experiments to measure the arrival time distributions of muons were started in 1981 and those of electrons in early 1983 in the Akeno air-shower array (930 gcm cm squared atmospheric depth, 900m above sea level). During the time of observation, the detection area of the Akeno array was expanded from 1 sq km to sq km in 1982 and to 20 sq km in 1984. Now the arrival time distribution of electrons and muons can be measured for showers with primary energies above 1019eV at large core distances.

  19. The hemodynamic effects of the LVAD outflow cannula location on the thrombi distribution in the aorta: A primary numerical study.

    PubMed

    Zhang, Yage; Gao, Bin; Yu, Chang

    2016-09-01

    Although a growing number of patients undergo LVAD implantation for heart failure treatment, thrombi are still the devastating complication for patients who used LVAD. LVAD outflow cannula location and thrombi generation sources were hypothesized to affect the thrombi distribution in the aorta. To test this hypothesis, numerical studies were conducted by using computational fluid dynamic (CFD) theory. Two anastomotic configurations, in which the LVAD outflow cannula is anastomosed to the anterior and lateral ascending aortic wall (named as anterior configurations and lateral configurations, respectively), are designed. The particles, whose sized are same as those of thrombi, are released at the LVAD output cannula and the aortic valve (named as thrombiP and thrombiL, respectively) to calculate the distribution of thrombi. The simulation results demonstrate that the thrombi distribution in the aorta is significantly affected by the LVAD outflow cannula location. In anterior configuration, the thrombi probability of entering into the three branches is 23.60%, while that in lateral configuration is 36.68%. Similarly, in anterior configuration, the thrombi probabilities of entering into brachiocephalic artery, left common carotid artery and left subclavian artery, is 8.51%, 9.64%, 5.45%, respectively, while that in lateral configuration it is 11.39%, 3.09%, 22.20% respectively. Moreover, the origins of thrombi could affect their distributions in the aorta. In anterior configuration, the thrombiP has a lower probability to enter into the three branches than thrombiL (12% vs. 25%). In contrast, in lateral configuration, the thrombiP has a higher probability to enter into the three branches than thrombiL (47% vs. 35%). In brief, the LVAD outflow cannula location significantly affects the distribution of thrombi in the aorta. Thus, in the clinical practice, the selection of outflow location of LVAD and the risk of thrombi formed in the left ventricle should be paid more

  20. 30 CFR 77.800-2 - Testing, examination, and maintenance of circuit breakers; record.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.800-2 Testing... test, examination, repair, or adjustment of all circuit breakers protecting high-voltage circuits....

  1. 30 CFR 77.800-2 - Testing, examination, and maintenance of circuit breakers; record.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.800-2 Testing... test, examination, repair, or adjustment of all circuit breakers protecting high-voltage circuits....

  2. 30 CFR 77.800-2 - Testing, examination, and maintenance of circuit breakers; record.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.800-2 Testing... test, examination, repair, or adjustment of all circuit breakers protecting high-voltage circuits....

  3. 30 CFR 77.800-2 - Testing, examination, and maintenance of circuit breakers; record.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.800-2 Testing... test, examination, repair, or adjustment of all circuit breakers protecting high-voltage circuits....

  4. ROBUST CIRCUIT RHYTHMS IN SMALL CIRCUITS ARISE FROM VARIABLE CIRCUIT COMPONENTS AND MECHANISMS

    PubMed Central

    Marder, Eve; Goeritz, Marie L.; Otopalik, Adriane G.

    2014-01-01

    Small central pattern generating circuits found in invertebrates have significant advantages for the study of the circuit mechanisms that generate brain rhythms. Experimental and computational studies of small oscillatory circuits reveal that similar rhythms can arise from disparate mechanisms. Animal-to-animal variation in the properties of single neurons and synapses may underly robust circuit performance, and can be revealed by perturbations. Neuromodulation can produce altered circuit performance but also ensure reliable circuit function. PMID:25460072

  5. Stochastically driven genetic circuits

    NASA Astrophysics Data System (ADS)

    Tsimring, L. S.; Volfson, D.; Hasty, J.

    2006-06-01

    Transcriptional regulation in small genetic circuits exhibits large stochastic fluctuations. Recent experiments have shown that a significant fraction of these fluctuations is caused by extrinsic factors. In this paper we review several theoretical and computational approaches to modeling of small genetic circuits driven by extrinsic stochastic processes. We propose a simplified approach to this problem, which can be used in the case when extrinsic fluctuations dominate the stochastic dynamics of the circuit (as appears to be the case in eukaryots). This approach is applied to a model of a single nonregulated gene that is driven by a certain gating process that affects the rate of transcription, and to a simplified version of the galactose utilization circuit in yeast.

  6. Power supply conditioning circuit

    NASA Technical Reports Server (NTRS)

    Primas, Lori E. (Inventor); Loveland, Rohan C. (Inventor)

    1988-01-01

    A conditioning circuit is provided with a constant current diode in series with a zener diode, the former having a high dynamic impedance and the latter a low dynamic impedance. The constant current diode can receive an input voltage with PARD. In conjunction with the zener diode fixed to a ground, a voltage divider is provided which can give an output voltage whose PARD was significantly reduced. The conditioning circuit is effective down to dc.

  7. Distribution of the Primary Endosymbiont (Candidatus Uzinura Diaspidicola) Within Host Insects from the Scale Insect Family Diaspididae.

    PubMed

    Gruwell, Matthew E; Flarhety, Meghan; Dittmar, Katharina

    2012-02-29

    It has long been known that armored scale insects harbor endosymbiotic bacteria inside specialized cells called bacteriocytes. Originally, these endosymbionts were thought to be fungal symbionts but they are now known to be bacterial and have been named Uzinura diaspidicola. Bacteriocyte and endosymbiont distribution patterns within host insects were visualized using in situ hybridization via 16S rRNA specific probes. Images of scale insect embryos, eggs and adult scale insects show patterns of localized bacteriocytes in embryos and randomly distributed bacteriocytes in adults. The symbiont pocket was not found in the armored scale insect eggs that were tested. The pattern of dispersed bacteriocytes in adult scale insects suggest that Uzinura and Blattabacteria may share some homologous traits that coincide with similar life style requirements, such as dispersal in fat bodies and uric acid recycling.

  8. Distribution of primary cochlear afferents in the bulbar nuclei of the rat: a horseradish peroxidase (HRP) study in parasagittal sections.

    PubMed Central

    Merchan, M A; Collia, F P; Merchan, J A; Ludeña, M D

    1986-01-01

    HRP was injected into the cochleae of 25 young albino rats in order to trace the primary afferents to the bulbar cochlear nuclei. Besides the classic V-shaped pattern and unconnected with it, HRP labelling revealed two plexuses stemming directly from the axons of the cochlear root. The plexuses cover the posterior area of the posteroventral cochlear nucleus (posterior plexus) and the anterolaterodorsal area of the anteroventral cochlear nucleus (anterior plexus). The fibres giving rise to these two plexuses were previously grouped in two bundles which have been called the posterior and anterior bundles, respectively. The origin of the anterior bundle is typically seen with the fibres stemming out at right angles; the origin and course of the posterior bundle, which characteristically cross over, is also a typical feature. Images Fig. 1 Figs. 2-3 (cont.) Figs. 2-3 Fig. 4 PMID:3319993

  9. Circuit simulation: some humbling thoughts

    SciTech Connect

    Wendt, Manfred; /Fermilab

    2006-01-01

    A short, very personal note on circuit simulation is presented. It does neither include theoretical background on circuit simulation, nor offers an overview of available software, but just gives some general remarks for a discussion on circuit simulator needs in context to the design and development of accelerator beam instrumentation circuits and systems.

  10. Superconducting flux flow digital circuits

    DOEpatents

    Hietala, V.M.; Martens, J.S.; Zipperian, T.E.

    1995-02-14

    A NOR/inverter logic gate circuit and a flip flop circuit implemented with superconducting flux flow transistors (SFFTs) are disclosed. Both circuits comprise two SFFTs with feedback lines. They have extremely low power dissipation, very high switching speeds, and the ability to interface between Josephson junction superconductor circuits and conventional microelectronics. 8 figs.

  11. Superconducting flux flow digital circuits

    DOEpatents

    Hietala, Vincent M.; Martens, Jon S.; Zipperian, Thomas E.

    1995-01-01

    A NOR/inverter logic gate circuit and a flip flop circuit implemented with superconducting flux flow transistors (SFFTs). Both circuits comprise two SFFTs with feedback lines. They have extremely low power dissipation, very high switching speeds, and the ability to interface between Josephson junction superconductor circuits and conventional microelectronics.

  12. Power supply circuit for an ion engine sequentially operated power inverters

    NASA Technical Reports Server (NTRS)

    Cardwell, Jr., Gilbert I. (Inventor)

    2000-01-01

    A power supply circuit for an ion engine suitable for a spacecraft has a voltage bus having input line and a return line. The power supply circuit includes a pulse width modulation circuit. A plurality of bridge inverter circuits is coupled to the bus and the pulse width modulation circuit. The pulse width modulation circuit generates operating signals having a variable duty cycle. Each bridge inverter has a primary winding and a secondary winding. Each secondary winding is coupled to a rectifier bridge. Each secondary winding is coupled in series with another of the plurality of rectifier bridges.

  13. Multi-purpose droop controllers incorporating a passivity-based stabilizer for unified control of electronically interfaced distributed generators including primary source dynamics.

    PubMed

    Azimi, Seyed Mohammad; Afsharnia, Saeed

    2016-07-01

    This paper presents multi-purpose droop controllers for electronically-interfaced distributed generators (EI-DGs). These controllers allow the micro-grids to operate in grid-connected mode, islanded mode and mode transition transients with a unique control configuration. The active and reactive-power sharing among EI-DGs are satisfied by the proposed droop controllers in islanded mode. On the other hand, in the grid-connected mode, the droop controllers adjust the output active and reactive-powers of EI-DGs at the pre-programmed constant levels. The provision of sufficient damping capability and maintenance of the transient stability in all operational modes of EI-DGs are warranted by the suggested stabilizer. This stabilizer, which is designed using the passivity-based control (PBC) approach, is incorporated in the droop controllers to dampen power-angle, frequency and voltage deviations during large transients using solely local information. The primary source dynamics of EI-DGs are also considered. It is analytically proven that the presence of the primary source dynamics leads to attenuation of the damping capability of EI-DGs in transients. To compensate the adverse effect of the primary source dynamics during transients a novel compensator is inserted in the frequency-droop loop. Finally, time-domain simulations are performed on a multi-resources MG to verify the analytical results compared to those obtained, based on a recently-developed strategy.

  14. Spatial patterns of primary productivity derived from the Dynamic Habitat Indices predict patterns of species richness and distributions in the tropics

    NASA Astrophysics Data System (ADS)

    Suttidate, Naparat

    Humans are changing the Earth's ecosystems, which has profound consequences for biodiversity. To understand how species respond to these changes, biodiversity science requires accurate assessments of biodiversity. However, biodiversity assessments are still limited in tropical regions. The Dynamic Habitat Indices (DHIs), derived from satellite data, summarize dynamic patterns of annual primary productivity: (a) cumulative annual productivity, (b) minimum annual productivity, and (c) seasonal variation in productivity. The DHIs have been successfully used in temperate regions, but not yet in the tropics. My goal was to evaluate the importance of primary productivity measured via the DHIs for assessing patterns of species richness and distributions in Thailand. First, I assessed the relationships between the DHIs and tropical bird species richness. I also evaluated the complementarity of the DHIs and topography, climate, latitudinal gradients, habitat heterogeneity, and habitat area in explaining bird species richness. I found that among three DHIs, cumulative annual productivity was the most important factor in explaining bird species richness and that the DHIs outperformed other environmental variables. Second, I developed texture measures derive from DHI cumulative annual productivity, and compared them to habitat composition and fragmentation as predictors of tropical forest bird distributions. I found that adding texture measures to habitat composition and fragmentation models improved the prediction of tropical bird distributions, especially area- and edge-sensitive tropical forest bird species. Third, I predicted the effects of trophic interactions between primary productivity, prey, and predators in relation to habitat connectivity for Indochinese tigers (Panthera tigris). I found that including trophic interactions improved habitat suitability models for tigers. However, tiger habitat is highly fragmented with few dispersal corridors. I also identified

  15. Spatial variability of primary organic sources regulates ichthyofauna distribution despite seasonal influence in Terminos lagoon and continental shelf of Campeche, Mexico

    NASA Astrophysics Data System (ADS)

    Romo Rios, J. A.; Aguíñiga-García, S.; Sanchez, A.; Zetina-Rejón, M.; Arreguín-Sánchez, F.; Tripp-Valdéz, A.; Galeana-Cortazár, A.

    2013-05-01

    Human activities have strong impacts on coastal ecosystems functioning through their effect on primary organic sources distributions and resulting biodiversity. Hence, it appears to be of utmost importance to quantify contribution of primary producers to sediment organic matter (SOM) spatial variability and its associated ichthyofauna. The Terminos lagoon (Gulf of Mexico) is a tropical estuary severely impacted by human activities even though of primary concern for its biodiversity, its habitats, and its resource supply. Stable isotope data (d13C, d15N) from mangrove, seaweed, seagrass, phytoplankton, ichthyofauna and SOM were sampled in four zones of the lagoon and the continental shelf through windy (November to February), dry (March to June) and rainy (July to October) seasons. Stable Isotope Analysis in R (SIAR) mixing model were used to determine relative contributions of the autotrophic sources to the ichthyofauna and SOM. Analysis of variance of ichthyofauna isotopic values showed significant differences (P < 0.001) in the four zones of lagoon despite the variability introduced by the windy, dry and rainy seasons. In lagoons rivers discharge zone, the mangrove contribution to ichthyofauna was 40% and 84% to SOM. Alternative use of habitat by ichthyofauna was evidenced since in the deep area of the lagoon (4 m), the contribution of mangrove to fish is 50%, and meanwhile contribution to SOM is only 77%. Although phytoplankton (43%) and seaweed (41%) contributions to the adjacent continental shelf ichthyofauna were the main organic sources, there was 37% mangrove contribution to SOM, demonstrating conspicuous terrigenous influence from lagoon ecosystem. Our results point toward organic sources spatial variations that regulate fish distribution. In Terminos lagoon, significant correlation (p-value = 0.2141 and r=0.79) of Ariopsis felis and Sphoeroides testudineus abundances and seaweed and seagrasses contributions (30-35%) during both dry and rainy seasons

  16. Farming the planet: 2. Geographic distribution of crop areas, yields, physiological types, and net primary production in the year 2000

    NASA Astrophysics Data System (ADS)

    Monfreda, Chad; Ramankutty, Navin; Foley, Jonathan A.

    2008-03-01

    Croplands cover ~15 million km2 of the planet and provide the bulk of the food and fiber essential to human well-being. Most global land cover data sets from satellites group croplands into just a few categories, thereby excluding information that is critical for answering key questions ranging from biodiversity conservation to food security to biogeochemical cycling. Information about agricultural land use practices like crop selection, yield, and fertilizer use is even more limited. Here we present land use data sets created by combining national, state, and county level census statistics with a recently updated global data set of croplands on a 5 min by 5 min (~10 km by 10 km) latitude-longitude grid. The resulting land use data sets depict circa the year 2000 the area (harvested) and yield of 175 distinct crops of the world. We aggregate these individual crop maps to produce novel maps of 11 major crop groups, crop net primary production, and four physiologically based crop types: annuals/perennials, herbaceous/shrubs/trees, C3/C4, and leguminous/nonleguminous.

  17. Risk Factors and Spatial Distribution of Schistosoma mansoni Infection among Primary School Children in Mbita District, Western Kenya

    PubMed Central

    Nagi, Sachiyo; Chadeka, Evans A.; Sunahara, Toshihiko; Mutungi, Faith; Justin, Yombo K. Dan; Kaneko, Satoshi; Ichinose, Yoshio; Matsumoto, Sohkichi; Njenga, Sammy M.; Hashizume, Masahiro; Shimada, Masaaki; Hamano, Shinjiro

    2014-01-01

    Background An increasing risk of Schistosoma mansoni infection has been observed around Lake Victoria, western Kenya since the 1970s. Understanding local transmission dynamics of schistosomiasis is crucial in curtailing increased risk of infection. Methodology/Principal Findings We carried out a cross sectional study on a population of 310 children from eight primary schools. Overall, a total of 238 (76.8%) children were infected with S. mansoni, while seven (2.3%) had S. haematobium. The prevalence of hookworm, Trichuris trichiura and Ascaris lumbricoides were 6.1%, 5.2% and 2.3%, respectively. Plasmodium falciparum was the only malaria parasite detected (12.0%). High local population density within a 1 km radius around houses was identified as a major independent risk factor of S. mansoni infection. A spatial cluster of high infection risk was detected around the Mbita causeway following adjustment for population density and other potential risk factors. Conclusions/Significance Population density was shown to be a major factor fuelling schistosome infection while individual socio-economic factors appeared not to affect the infection risk. The high-risk cluster around the Mbita causeway may be explained by the construction of an artificial pathway that may cause increased numbers of S. mansoni host snails through obstruction of the waterway. This construction may have, therefore, a significant negative impact on the health of the local population, especially school-aged children who frequently come in contact with lake water. PMID:25058653

  18. Two-photon mapping of neocortical circuits

    NASA Astrophysics Data System (ADS)

    Nikolenko, Volodymyr

    The synaptic circuits of the cerebral cortex are still poorly understood, yet knowing their basic structure appears key for understanding their function (Lorente de No, 1949). While some argue that there is a basic modular circuit present in all cortical regions (Douglas et al., 1989; Hubel and Wiesel, 1977), others suggest that synaptic circuits could be randomly structured (Braitenberg and Schuz, 1998). To investigate the patterns of synaptic connections present in neocortex, I have developed a novel two-photon optical mapping method (Nikolenko et al., 2007) to systematically reveal cells that connect to four classes of neurons in slices of mouse primary sensory cortex. Inputs to these cells originated preferentially from specific cortical layers and often were laterally restricted, revealing functional columnar circuits with sharp boundaries. Moreover, many neurons extensively sampled particular territories, and, in some cases, virtually every cell from a particular layer was connected to the postsynaptic target. The results reveal circuits with dense columnar connectivity, approximating in some cases the complete sampling from every potential presynaptic cell in an input layer. I discuss the implications of these findings in the context of the computational strategies used by the cortex.

  19. Current regulating circuit

    SciTech Connect

    Hoffman, Ph. A.

    1985-03-12

    A battery charger which includes terminals for connection to an electric power source, an electrical charging circuit and an operative arrangement for connecting at least one rechargeable battery cell, in series with the charging circuit across the terminals. The battery charger has a charging circuit which includes a first resistor, a second resistor, a third resistor and a rectifier, constituted by at least one diode, in series. A first transistor, which has a collector-emitter path and a base-emitter path, is operatively connected so that the base-emitter path is connected in parallel with the first resistor. A fourth resistor is provided, the fourth resistor being connected in series with the collector-emitter path of the transistor and the third resistor. A plurality of additional transistors, connected in Darlington configuration, includes a second transistor and a final transistor, each of the additional transistors having its collector connected to a circuit point between the third resistor and an electrode of the diode. The first transistor and the last transistor have their emitters connected via a current-limiting PTC fifth resistor which may act as a fuse. The first transistor and the second transistor have their respective collector and base conductively connected. The connection of the third resistor provides internal feedback. The fifth resistor, when in series with the first resistor in the base-emitter circuit, provides external feedback.

  20. Applying analog integrated circuits for HERO protection

    NASA Technical Reports Server (NTRS)

    Willis, Kenneth E.; Blachowski, Thomas J.

    1994-01-01

    One of the most efficient methods for protecting electro-explosive devices (EED's) from HERO and ESD is to shield the EED in a conducting shell (Faraday cage). Electrical energy is transferred to the bridge by means of a magnetic coupling which passes through a portion of the conducting shell that is made from a magnetically permeable but electrically conducting material. This technique was perfected by ML Aviation, a U.K. company, in the early 80's, and was called a Radio Frequency Attenuation Connector (RFAC). It is now in wide use in the U.K. Previously, the disadvantage of RFAC over more conventional methods was its relatively high cost, largely driven by a thick film hybrid circuit used to switch the primary of the transformer. Recently, through a licensing agreement, this technology has been transferred to the U.S. and significant cost reductions and performance improvements have been achieved by the introduction of analog integrated circuits. An integrated circuit performs the following functions: (1) Chops the DC input to a signal suitable for driving the primary of the transformer; (2) Verifies the input voltage is above a threshold; (3) Verifies the input voltage is valid for a pre set time before enabling the device; (4) Provides thermal protection of the circuit; and (5) Provides an external input for independent logic level enabling of the power transfer mechanism. This paper describes the new RFAC product and its applications.

  1. ELECTRONIC TRIGGER CIRCUIT

    DOEpatents

    Russell, J.A.G.

    1958-01-01

    An electronic trigger circuit is described of the type where an output pulse is obtained only after an input voltage has cqualed or exceeded a selected reference voltage. In general, the invention comprises a source of direct current reference voltage in series with an impedance and a diode rectifying element. An input pulse of preselected amplitude causes the diode to conduct and develop a signal across the impedance. The signal is delivered to an amplifier where an output pulse is produced and part of the output is fed back in a positive manner to the diode so that the amplifier produces a steep wave front trigger pulsc at the output. The trigger point of the described circuit is not subject to variation due to the aging, etc., of multi-electrode tabes, since the diode circuit essentially determines the trigger point.

  2. Logsum Using Garbled Circuits

    PubMed Central

    Portêlo, José; Raj, Bhiksha; Trancoso, Isabel

    2015-01-01

    Secure multiparty computation allows for a set of users to evaluate a particular function over their inputs without revealing the information they possess to each other. Theoretically, this can be achieved using fully homomorphic encryption systems, but so far they remain in the realm of computational impracticability. An alternative is to consider secure function evaluation using homomorphic public-key cryptosystems or Garbled Circuits, the latter being a popular trend in recent times due to important breakthroughs. We propose a technique for computing the logsum operation using Garbled Circuits. This technique relies on replacing the logsum operation with an equivalent piecewise linear approximation, taking advantage of recent advances in efficient methods for both designing and implementing Garbled Circuits. We elaborate on how all the required blocks should be assembled in order to obtain small errors regarding the original logsum operation and very fast execution times. PMID:25811740

  3. ELECTRONIC MULTIPLIER CIRCUIT

    DOEpatents

    Thomas, R.E.

    1959-08-25

    An electronic multiplier circuit is described in which an output voltage having an amplitude proportional to the product or quotient of the input signals is accomplished in a novel manner which facilitates simplicity of circuit construction and a high degree of accuracy in accomplishing the multiplying and dividing function. The circuit broadly comprises a multiplier tube in which the plate current is proportional to the voltage applied to a first control grid multiplied by the difference between voltage applied to a second control grid and the voltage applied to the first control grid. Means are provided to apply a first signal to be multiplied to the first control grid together with means for applying the sum of the first signal to be multiplied and a second signal to be multiplied to the second control grid whereby the plate current of the multiplier tube is proportional to the product of the first and second signals to be multiplied.

  4. ELECTRONIC PHASE CONTROL CIRCUIT

    DOEpatents

    Salisbury, J.D.; Klein, W.W.; Hansen, C.F.

    1959-04-21

    An electronic circuit is described for controlling the phase of radio frequency energy applied to a multicavity linear accelerator. In one application of the circuit two cavities are excited from a single radio frequency source, with one cavity directly coupled to the source and the other cavity coupled through a delay line of special construction. A phase detector provides a bipolar d-c output signal proportional to the difference in phase between the voltage in the two cavities. This d-c signal controls a bias supply which provides a d-c output for varying the capacitnce of voltage sensitive capacitors in the delay line. The over-all operation of the circuit is completely electronic, overcoming the time response limitations of the electromechanical control systems, and the relative phase relationship of the radio frequency voltages in the two caviiies is continuously controlled to effect particle acceleration.

  5. Distribution and quantitation of skin iron in primary haemochromatosis: correlation with total body iron stores in patients undergoing phlebotomy.

    PubMed

    Pinheiro, Teresa; Silva, Raquel; Fleming, Rita; Gonçalves, Afonso; Barreiros, Maria A; Silva, João N; Morlière, Patrice; Santus, René; Filipe, Paulo

    2014-01-01

    Measurement of the concentration of iron in the skin, if correlated with total body iron stores, may enable better informed decisions on when to initiate, change or stop therapy in hereditary heamochromatosis. Naïve haemochromatosis patients with iron overload and with C282Y and/or H63D HFE mutations were evaluated at the following time-points: disease diagnosis, end of the therapy programme, and 6 months after the end of therapy. The distribution and concentration of iron in the skin were assessed by quantitative nuclear microscopy methods, in parallel with serum and plasma iron concentration. Iron content in the liver was determined by nuclear magnetic resonance. Iron accumulated in the epidermis; its concentration increased from outer to inner layers, being maximal in the basal layer (7.33 ± 0.98 µmol/g). At all 3 time-points, most of the iron was associated with the extracellular space. During the phlebotomy programme the iron content of the skin and the liver decreased by a factor of 2. These data suggest that measurements of iron concentration in the epidermis, which is a readily accessible tissue, reflect iron overload in the liver.

  6. Micromachined Silicon Waveguide Circuits

    NASA Technical Reports Server (NTRS)

    McGrath, W. R.

    1995-01-01

    Rectangular waveguides are commonly used as circuit elements in remote-sensing heterodyne receivers at millimeter wavelengths. The advantages of waveguides are low loss and mechanical tunability. However, conventional machining techniques for waveguide components operating above a few hundred GHz are complicated and costly. Waveguides micromachined from silicon however would have several important advantages including low-cost; small size for very high frequency (submillimeter wave) operation; high dimensional accuracy (important for high-Q circuits); atomically smooth walls, thereby reducing rf losses; and the ability to integrate active and passive devices directly in the waveguide on thin membranes, thereby solving the traditional problem of mounting thin substrates.

  7. Inrush Current Control Circuit

    NASA Technical Reports Server (NTRS)

    Cole, Steven W. (Inventor)

    2002-01-01

    An inrush current control circuit having an input terminal connected to a DC power supply and an output terminal connected to a load capacitor limits the inrush current that charges up the load capacitor during power up of a system. When the DC power supply applies a DC voltage to the input terminal, the inrush current control circuit produces a voltage ramp at the load capacitor instead of an abrupt DC voltage. The voltage ramp results in a constant low level current to charge up the load capacitor, greatly reducing the current drain on the DC power supply.

  8. Electrical Circuit Tester

    DOEpatents

    Love, Frank

    2006-04-18

    An electrical circuit testing device is provided, comprising a case, a digital voltage level testing circuit with a display means, a switch to initiate measurement using the device, a non-shorting switching means for selecting pre-determined electrical wiring configurations to be tested in an outlet, a terminal block, a five-pole electrical plug mounted on the case surface and a set of adapters that can be used for various multiple-pronged electrical outlet configurations for voltages from 100 600 VAC from 50 100 Hz.

  9. Automatic level control circuit

    NASA Technical Reports Server (NTRS)

    Toole, P. C.; Mccarthy, D. M. (Inventor)

    1983-01-01

    An automatic level control circuit for an operational amplifier for minimizing spikes or instantaneous gain of the amplifier at a low period wherein no signal is received on the input is provided. The apparatus includes a multibranch circuit which is connected between an output terminal and a feedback terminal. A pair of zener diodes are connected back to back in series with a capacitor provided in one of the branches. A pair of voltage dividing resistors are connected in another of the branches and a second capacitor is provided in the remaining branch of controlling the high frequency oscillations of the operational amplifier.

  10. Small circuits for cryptography.

    SciTech Connect

    Torgerson, Mark Dolan; Draelos, Timothy John; Schroeppel, Richard Crabtree; Miller, Russell D.; Anderson, William Erik

    2005-10-01

    This report examines a number of hardware circuit design issues associated with implementing certain functions in FPGA and ASIC technologies. Here we show circuit designs for AES and SHA-1 that have an extremely small hardware footprint, yet show reasonably good performance characteristics as compared to the state of the art designs found in the literature. Our AES performance numbers are fueled by an optimized composite field S-box design for the Stratix chipset. Our SHA-1 designs use register packing and feedback functionalities of the Stratix LE, which reduce the logic element usage by as much as 72% as compared to other SHA-1 designs.

  11. Wein bridge oscillator circuit

    NASA Technical Reports Server (NTRS)

    Lipoma, P. C.

    1971-01-01

    Circuit with minimum number of components provides stable outputs of 2 to 8 volts at frequencies of .001 to 100 kHz. Oscillator exhibits low power consumption, portability, simplicity, and drive capability, it has application as loudspeaker tester and audible alarm, as well as in laboratory and test generators.

  12. Automatic sweep circuit

    DOEpatents

    Keefe, Donald J.

    1980-01-01

    An automatically sweeping circuit for searching for an evoked response in an output signal in time with respect to a trigger input. Digital counters are used to activate a detector at precise intervals, and monitoring is repeated for statistical accuracy. If the response is not found then a different time window is examined until the signal is found.

  13. "Printed-circuit" rectenna

    NASA Technical Reports Server (NTRS)

    Dickinson, R. M.

    1977-01-01

    Rectifying antenna is less bulky structure for absorbing transmitted microwave power and converting it into electrical current. Printed-circuit approach, using microstrip technology and circularly polarized antenna, makes polarization orientation unimportant and allows much smaller arrays for given performance. Innovation is particularly useful with proposed electric vehicles powered by beam microwaves.

  14. A coherent RC circuit

    NASA Astrophysics Data System (ADS)

    Gabelli, J.; Fève, G.; Berroir, J.-M.; Plaçais, B.

    2012-12-01

    We review the first experiment on dynamic transport in a phase-coherent quantum conductor. In our discussion, we highlight the use of time-dependent transport as a means of gaining insight into charge relaxation on a mesoscopic scale. For this purpose, we studied the ac conductance of a model quantum conductor, i.e. the quantum RC circuit. Prior to our experimental work, Büttiker et al (1993 Phys. Lett. A 180 364-9) first worked on dynamic mesoscopic transport in the 1990s. They predicted that the mesoscopic RC circuit can be described by a quantum capacitance related to the density of states in the capacitor and a constant charge-relaxation resistance equal to half of the resistance quantum h/2e2, when a single mode is transmitted between the capacitance and a reservoir. By applying a microwave excitation to a gate located on top of a coherent submicronic quantum dot that is coupled to a reservoir, we validate this theoretical prediction on the ac conductance of the quantum RC circuit. Our study demonstrates that the ac conductance is directly related to the dwell time of electrons in the capacitor. Thereby, we observed a counterintuitive behavior of a quantum origin: as the transmission of the single conducting mode decreases, the resistance of the quantum RC circuit remains constant while the capacitance oscillates.

  15. Electrifying Inquiry: Electrical Circuits

    ERIC Educational Resources Information Center

    Godbey, Susan; Barnett, Jessica; Webster, Lois

    2005-01-01

    An activity involving parallel electrical circuits was modified to incorporate an open inquiry approach. Both the original and revised versions of the activity were tested in the middle school classroom. We present a comparison of the two versions of the activity in terms of facilitating learning and engaging students' interests.

  16. A Magnetic Circuit Demonstration.

    ERIC Educational Resources Information Center

    Vanderkooy, John; Lowe, June

    1995-01-01

    Presents a demonstration designed to illustrate Faraday's, Ampere's, and Lenz's laws and to reinforce the concepts through the analysis of a two-loop magnetic circuit. Can be made dramatic and challenging for sophisticated students but is suitable for an introductory course in electricity and magnetism. (JRH)

  17. Integrated circuit reliability testing

    NASA Technical Reports Server (NTRS)

    Buehler, Martin G. (Inventor); Sayah, Hoshyar R. (Inventor)

    1990-01-01

    A technique is described for use in determining the reliability of microscopic conductors deposited on an uneven surface of an integrated circuit device. A wafer containing integrated circuit chips is formed with a test area having regions of different heights. At the time the conductors are formed on the chip areas of the wafer, an elongated serpentine assay conductor is deposited on the test area so the assay conductor extends over multiple steps between regions of different heights. Also, a first test conductor is deposited in the test area upon a uniform region of first height, and a second test conductor is deposited in the test area upon a uniform region of second height. The occurrence of high resistances at the steps between regions of different height is indicated by deriving the measured length of the serpentine conductor using the resistance measured between the ends of the serpentine conductor, and comparing that to the design length of the serpentine conductor. The percentage by which the measured length exceeds the design length, at which the integrated circuit will be discarded, depends on the required reliability of the integrated circuit.

  18. Integrated circuit reliability testing

    NASA Technical Reports Server (NTRS)

    Buehler, Martin G. (Inventor); Sayah, Hoshyar R. (Inventor)

    1988-01-01

    A technique is described for use in determining the reliability of microscopic conductors deposited on an uneven surface of an integrated circuit device. A wafer containing integrated circuit chips is formed with a test area having regions of different heights. At the time the conductors are formed on the chip areas of the wafer, an elongated serpentine assay conductor is deposited on the test area so the assay conductor extends over multiple steps between regions of different heights. Also, a first test conductor is deposited in the test area upon a uniform region of first height, and a second test conductor is deposited in the test area upon a uniform region of second height. The occurrence of high resistances at the steps between regions of different height is indicated by deriving the measured length of the serpentine conductor using the resistance measured between the ends of the serpentine conductor, and comparing that to the design length of the serpentine conductor. The percentage by which the measured length exceeds the design length, at which the integrated circuit will be discarded, depends on the required reliability of the integrated circuit.

  19. Circuit breaker lockout device

    DOEpatents

    Kozlowski, Lawrence J.; Shirey, Lawrence A.

    1992-01-01

    An improved lockout assembly for locking a circuit breaker in a selected off or on position is provided. The lockout assembly includes a lock block and a lock pin. The lock block has a hollow interior which fits over the free end of a switch handle of the circuit breaker. The lock block includes at least one hole that is placed in registration with a hole in the free end of the switch handle. A lock tab on the lock block serves to align and register the respective holes on the lock block and switch handle. A lock pin is inserted through the registered holes and serves to connect the lock block to the switch handle. Once the lock block and the switch handle are connected, the position of the switch handle is prevented from being changed by the lock tab bumping up against a stationary housing portion of the circuit breaker. When the lock pin installed, an apertured-end portion of the lock pin is in registration with another hole on the lock block. Then a special scissors conforming to O.S.H.A. regulations can be installed, with one or more padlocks, on the lockout assembly to prevent removal of the lock pin from the lockout assembly, thereby preventing removal of the lockout assembly from the circuit breaker.

  20. Circuit breaker lockout device

    DOEpatents

    Kozlowski, L.J.; Shirey, L.A.

    1992-11-24

    An improved lockout assembly for locking a circuit breaker in a selected off or on position is provided. The lockout assembly includes a lock block and a lock pin. The lock block has a hollow interior which fits over the free end of a switch handle of the circuit breaker. The lock block includes at least one hole that is placed in registration with a hole in the free end of the switch handle. A lock tab on the lock block serves to align and register the respective holes on the lock block and switch handle. A lock pin is inserted through the registered holes and serves to connect the lock block to the switch handle. Once the lock block and the switch handle are connected, the position of the switch handle is prevented from being changed by the lock tab bumping up against a stationary housing portion of the circuit breaker. When the lock pin installed, an apertured-end portion of the lock pin is in registration with another hole on the lock block. Then a special scissors conforming to O.S.H.A. regulations can be installed, with one or more padlocks, on the lockout assembly to prevent removal of the lock pin from the lockout assembly, thereby preventing removal of the lockout assembly from the circuit breaker. 2 figs.

  1. Energy management circuit

    SciTech Connect

    Corless, R. W.

    1985-10-15

    An energy management circuit for use in a telephone or other device which includes an electronic memory is disclosed. The invention provides a capacitive keep alive power supply to maintain said memory in an active condition during extended periods when the device is disconnected from a line power source, as in a telephone on-hook condition. A large capacitor charge is maintained within a predetermined voltage range during such disconnect conditions by a resistively coupled trickle charge power source. A comparator is operated to monitor capacitor charge and to produce a control signal when the voltage at the capacitor falls below a selected memory keep alive level. The control signal operates a switch to bypass the trickle charge circuit. The switch couples line power directly to the capacitor to charge the capacitor to a voltage sufficient to maintain memory contents intact. A switch inhibit circuit is provided to prevent trickle charge bypass during an inadequate or excessive line voltage condition. A sleep timer circuit is also provided to conserve energy required to operate the present invention by allowing the invention to operate periodically and only for short intervals.

  2. Bioluminescent bioreporter integrated circuit

    DOEpatents

    Simpson, Michael L.; Sayler, Gary S.; Paulus, Michael J.

    2000-01-01

    Disclosed are monolithic bioelectronic devices comprising a bioreporter and an OASIC. These bioluminescent bioreporter integrated circuit are useful in detecting substances such as pollutants, explosives, and heavy-metals residing in inhospitable areas such as groundwater, industrial process vessels, and battlefields. Also disclosed are methods and apparatus for environmental pollutant detection, oil exploration, drug discovery, industrial process control, and hazardous chemical monitoring.

  3. Chaos in Josephson circuits

    SciTech Connect

    Kautz, R.

    1983-05-01

    Chaotic behavior in Josephson circuits is reviewed using the rf-driven junction as an example. Topics include the effect of chaos on the I-V characteristic, the period doubling route to chaos, and power spectra for the chaotic state. Liapunov exponents and the fractal geometry of strange attractors are also discussed.

  4. Exploring Distributed Energy Alternatives to Electrical Distribution Grid Expansion in Souhern California Edison Service Territory

    SciTech Connect

    Stovall, Therese K; Kingston, Tim

    2005-12-01

    Distributed energy (DE) technologies have received much attention for the energy savings and electric power reliability assurances that may be achieved by their widespread adoption. Fueling the attention have been the desires to globally reduce greenhouse gas emissions and concern about easing power transmission and distribution system capacity limitations and congestion. However, these benefits may come at a cost to the electric utility companies in terms of lost revenue and concerns with interconnection on the distribution system. This study assesses the costs and benefits of DE to both consumers and distribution utilities and expands upon a precursory study done with Detroit Edison (DTE)1, by evaluating the combined impact of DE, energy-efficiency, photovoltaics (a use of solar energy), and demand response that will shape the grid of the future. This study was funded by the U.S. Department of Energy (DOE), Gas Research Institute (GRI), American Electric Power (AEP), and Gas Technology Institute's (GTI) Distributed Energy Collaborative Program (DECP). It focuses on two real Southern California Edison (SCE) circuits, a 13 MW suburban circuit fictitiously named Justice on the Lincoln substation, and an 8 MW rural circuit fictitiously named Prosper on the Washington Substation. The primary objectives of the study were threefold: (1) Evaluate the potential for using advanced energy technologies, including DE, energy-efficiency (EE), demand response, electricity storage, and photovoltaics (PV), to reshape electric load curves by reducing peak demand, for real circuits. (2) Investigate the potential impact on guiding technology deployment and managing operation in a way that benefits both utilities and their customers by: (a) Improving grid load factor for utilities; (b) Reducing energy costs for customers; and (c) Optimizing electric demand growth. (3) Demonstrate benefits by reporting on a recently installed advanced energy system at a utility customer site. This

  5. Primary and secondary particle contributions to the depth dose distribution in a phantom shielded from solar flare and Van Allen protons

    NASA Technical Reports Server (NTRS)

    Santoro, R. T.; Claiborne, H. C.; Alsmiller, R. G., Jr.

    1972-01-01

    Calculations have been made using the nucleon-meson transport code NMTC to estimate the absorbed dose and dose equivalent distributions in astronauts inside space vehicles bombarded by solar flare and Van Allen protons. A spherical shell shield of specific radius and thickness with a 30-cm-diam. tissue ball at the geometric center was used to simulate the spacecraft-astronaut configuration. The absorbed dose and the dose equivalent from primary protons, secondary protons, heavy nuclei, charged pions, muons, photons, and positrons and electrons are given as a function of depth in the tissue phantom. Results are given for solar flare protons with a characteristic rigidity of 100 MV and for Van Allen protons in a 240-nautical-mile circular orbit at 30 degree inclination angle incident on both 20-g/sq cm-thick aluminum and polyethylene spherical shell shields.

  6. Monte Carlo simulation of electron depth distribution and backscattering for carbon films deposited on aluminium as a function of incidence angle and primary energy

    NASA Astrophysics Data System (ADS)

    Dapor, Maurizio

    2005-01-01

    Carbon films are deposited on various substrates (polymers, polyester fabrics, polyester yarns, metal alloys) both for experimental and technological motivations (medical devices, biocompatible coatings, food package and so on). Computational studies of the penetration of electron beams in supported thin film of carbon are very useful in order to compare the simulated results with analytical techniques data (obtained by scanning electron microscopy and/or Auger electron spectroscopy) and investigate the film characteristics. In the present paper, the few keV electron depth distribution and backscattering coefficient for the special case of film of carbon deposited on aluminium are investigated, by a Monte Carlo simulation, as a function of the incidence angle and primary electron energy. The simulated results can be used as a way to evaluate the carbon film thickness by a set of measurements of the backscattering coefficient.

  7. Circuit for Communication Over Power Lines

    NASA Technical Reports Server (NTRS)

    Krasowski, Michael J.; Prokop, Normal F.; Greer, Lawrence C., III; Nappier, Jennifer

    2011-01-01

    Many distributed systems share common sensors and instruments along with a common power line supplying current to the system. A communication technique and circuit has been developed that allows for the simple inclusion of an instrument, sensor, or actuator node within any system containing a common power bus. Wherever power is available, a node can be added, which can then draw power for itself, its associated sensors, and actuators from the power bus all while communicating with other nodes on the power bus. The technique modulates a DC power bus through capacitive coupling using on-off keying (OOK), and receives and demodulates the signal from the DC power bus through the same capacitive coupling. The circuit acts as serial modem for the physical power line communication. The circuit and technique can be made of commercially available components or included in an application specific integrated circuit (ASIC) design, which allows for the circuit to be included in current designs with additional circuitry or embedded into new designs. This device and technique moves computational, sensing, and actuation abilities closer to the source, and allows for the networking of multiple similar nodes to each other and to a central processor. This technique also allows for reconfigurable systems by adding or removing nodes at any time. It can do so using nothing more than the in situ power wiring of the system.

  8. Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans

    PubMed Central

    Leinwand, Sarah G.; Chalasani, Sreekanth H.

    2013-01-01

    Neural circuits detect environmental changes and drive behavior. The routes of information flow through dense neural networks are dynamic; however, the mechanisms underlying this circuit flexibility are poorly understood. Here, we define a novel, sensory context-dependent and neuropeptide-regulated switch in the composition of a C. elegans salt sensory circuit. The primary salt detectors, ASE sensory neurons, use BLI-4 endoprotease-dependent cleavage to release the insulin-like peptide INS-6 in response to large but not small changes in external salt stimuli. Insulins, signaling through the insulin receptor DAF-2, functionally switch the AWC olfactory sensory neuron into an interneuron in the salt circuit. Animals with disrupted insulin signaling have deficits in salt attraction, suggesting that peptidergic signaling potentiates responses to high salt stimuli, which may promote ion homeostasis. Our results show that sensory context and neuropeptide signaling modify neural networks and suggest general mechanisms for generating flexible behavioral outputs by modulating neural circuit composition. PMID:24013594

  9. Operational research in primary health care planning: a theoretical model for estimating the coverage achieved by different distributions of staff and facilities

    PubMed Central

    Kemball-Cook, D.; Vaughan, J. P.

    1983-01-01

    This report outlines a basic operational research model for estimating the coverage achieved by different distributions of primary health care staff and facilities, using antenatal home visiting as an illustrative example. Coverage is estimated in terms of the average number of patient contacts achieved per annum. The model takes into account such features as number of facilities and health workers per 10 000 population, the radius of the health facility area, the overall population density in the region, the number of working days in the year, and the health worker's travelling time and work rate. A theoretical planning situation is also presented, showing the application of the model in defining various possible strategies, using certain planning norms for new levels of staff and facilities. This theoretical model is presented as an example of the use of operational research in primary health care, but it requires to be tested and validated in known situations before its usefulness can be assessed. Some indications are given of the ways in which the model could be adapted and improved for application to a real planning situation. PMID:6602666

  10. Temporal distribution of dengue virus serotypes in Colombian endemic area and dengue incidence. Re-introduction of dengue-3 associated to mild febrile illness and primary infection.

    PubMed

    Ocazionez, Raquel Elvira; Cortés, Fabián Mauricio; Villar, Luis Angel; Gómez, Sergio Yebrail

    2006-11-01

    We have investigated the temporal distribution of dengue (DEN) virus serotypes in the department (state) of Santander, Colombia, in relation to dengue incidence, infection pattern, and severity of disease. Viral isolation was attended on a total of 1452 acute serum samples collected each week from 1998 to 2004. The infection pattern was evaluated in 596 laboratory-positive dengue cases using an IgG ELISA, and PRNT test. The dengue incidence was documented by the local health authority. Predominance of DEN-1 in 1998 and DEN-3 re-introduction and predominance in 2001-2003 coincided with outbreaks. Predominance of DEN-2 in 2000-2001 coincided with more dengue hemorrhagic fever (DHF). DEN-4 was isolated in 2000-2001 and 2004 but was not predominant. There was an annual increase of primary dengue infections (from 13.7 to 81.4%) that correlated with frequency of DEN-3 (r = 0.83; P = 0.038). From the total number of primary dengue infections DEN-3 (81.3%) was the most frequent serotype. DHF was more frequent in DEN-2 infected patients than in DEN-3 infected patients: 27.5 vs 10.9% (P < 0.05). DEN-3 viruses belonged to subtype C (restriction site-specific-polymerase chain reaction) like viruses isolated in Sri-Lanka and other countries in the Americas. Our findings show the importance of continuous virological surveillance to identify the risk factors of dengue epidemics and severity.

  11. LIVER TYPE FATTY ACID BINDING PROTEIN (L-FABP) GENE ABLATION REDUCES NUCLEAR LIGAND DISTRIBUTION AND PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-α ACTIVITY IN CULTURED PRIMARY HEPATOCYTES1

    PubMed Central

    McIntosh, Avery L.; Atshaves, Barbara P.; Hostetler, Heather A.; Huang, Huan; Davis, Jason; Lyuksyutova, Olga I.; Landrock, Danilo; Kier, Ann B.; Schroeder, Friedhelm

    2009-01-01

    The effect of liver type fatty acid binding protein (L-FABP) gene ablation on the uptake and distribution of long chain fatty acids (LCFA) to the nucleus by real-time laser scanning confocal imaging and peroxisome proliferator activated receptor-α (PPARα) activity was examined in cultured primary hepatocytes from livers wild-type L-FABP+/+ and gene ablated L-FABP−/− mice. Cultured primary hepatocytes from livers of L-FABP−/− mice exhibited: (i) reduced oxidation of palmitic acid, a common dietary long chain fatty acid (LCFA); (ii) reduced expression of fatty acid oxidative enzymes—proteins transcriptionally regulated by PPARα; (iii) reduced palmitic acid-induced PPARα coimmunoprecipitation with coactivator SRC1 concomitant with increased PPARα coimmunoprecipitation with coinhibitor N-CoR; (iv) reduced palmitic acid-induced PPARα. Diminished PPARα activation in L-FABP null hepatocytes was associated with lower uptake of common dietary LCFA (palmitic acid as well as its fluorescent derivative BODIPY FL C16), reduced level of total unesterified LCFA, and real-time redistribution of BODIPY FL C16 from the central nucleoplasm to the nuclear envelope. Taken together, these studies support the hypothesis that L-FABP may facilitate ligand (LCFA)-activated PPARα transcriptional activity at least in part by increasing total LCFA ligand available to PPARα for inducing PPARα-mediated transcription of proteins involved in LCFA metabolism. PMID:19285478

  12. 30 CFR 75.800-3 - Testing, examination and maintenance of circuit breakers; procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... shall include visual observation of all components of the circuit breaker and its auxiliary devices, and... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Testing, examination and maintenance of circuit... High-Voltage Distribution § 75.800-3 Testing, examination and maintenance of circuit...

  13. 30 CFR 75.800-3 - Testing, examination and maintenance of circuit breakers; procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... shall include visual observation of all components of the circuit breaker and its auxiliary devices, and... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Testing, examination and maintenance of circuit... High-Voltage Distribution § 75.800-3 Testing, examination and maintenance of circuit...

  14. 30 CFR 75.800-3 - Testing, examination and maintenance of circuit breakers; procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... shall include visual observation of all components of the circuit breaker and its auxiliary devices, and... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Testing, examination and maintenance of circuit... High-Voltage Distribution § 75.800-3 Testing, examination and maintenance of circuit...

  15. 30 CFR 75.800-3 - Testing, examination and maintenance of circuit breakers; procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... shall include visual observation of all components of the circuit breaker and its auxiliary devices, and... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Testing, examination and maintenance of circuit... High-Voltage Distribution § 75.800-3 Testing, examination and maintenance of circuit...

  16. 30 CFR 75.800-3 - Testing, examination and maintenance of circuit breakers; procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... shall include visual observation of all components of the circuit breaker and its auxiliary devices, and... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Testing, examination and maintenance of circuit... High-Voltage Distribution § 75.800-3 Testing, examination and maintenance of circuit...

  17. 30 CFR 75.802 - Protection of high-voltage circuits extending underground.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection of high-voltage circuits extending...-Voltage Distribution § 75.802 Protection of high-voltage circuits extending underground. (a) Except as provided in paragraph (b) of this section, high-voltage circuits extending underground and...

  18. 30 CFR 75.803-1 - Maximum voltage ground check circuits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Underground High-Voltage Distribution § 75.803-1 Maximum voltage ground check circuits. The maximum voltage used for ground check circuits... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Maximum voltage ground check circuits....

  19. Asymmetric Switching For A PWM H-Bridge Power Circuit

    NASA Technical Reports Server (NTRS)

    Wong, See-Pok

    1995-01-01

    Only two of four switches interrupt substantial current. An asymmetric timing scheme improves design and operation of pulse-width-modulation (PWM) H-bridge switch-and-transformer circuit. Circuit part of dc-to-dc converter or dc-to-ac inverter; in either case, output current or voltage regulated by adjusting times of opening and closing of semiconductor switches 1 through 4 to adjust durations of current pulses in primary winding of transformer.

  20. Resistor Combinations for Parallel Circuits.

    ERIC Educational Resources Information Center

    McTernan, James P.

    1978-01-01

    To help simplify both teaching and learning of parallel circuits, a high school electricity/electronics teacher presents and illustrates the use of tables of values for parallel resistive circuits in which total resistances are whole numbers. (MF)

  1. Patchy distributions of myelin and vesicular glutamate transporter 2 align with cytochrome oxidase blobs and interblobs in the superficial layers of the primary visual cortex

    PubMed Central

    Rockoff, Emily C; Balaram, Pooja; Kaas, Jon H

    2015-01-01

    Blobs are a modular component of the primary visual cortex (area 17) of all primates, but not of other mammals closely related to primates. They are characterized as an even distribution of patches, puffs, or blobs of dense cytochrome oxidase (CO) expression in layer III of area 17, and are now known to differ from surrounding, nonblob cortex in thalamic, intrinsic, and extrastriate connections. Previous studies have also recognized a blob-like pattern of myelin-dense patches in layer III of area 17 of primates, and more recently the vesicular glutamate transporter (VGLUT)-2 isoform of the VGLUT family has been found to selectively distribute to layer III patches in a similar blob-like pattern. Here, we sought to determine if the blob-like patterns all identify the same modular structures in area 17 of primates by staining alternate brain sections cut parallel to the surface of area 17 of a prosimian primate (Otolemur garnettii) for CO, myelin, and VGLUT2. By aligning the sections from the three preparations, we provide clear evidence that the three preparations all identify the same modular blob structures. The results provide a further understanding of the functional nature of the blobs by demonstrating that their higher level of CO activity is related to thalamic inputs from the lateral geniculate nucleus that use VGLUT2 as their main glutamate transporter, and via myelinated axons. PMID:26097384

  2. Electronic circuits and systems: A compilation. [including integrated circuits, logic circuits, varactor diode circuits, low pass filters, and optical equipment circuits

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Technological information is presented electronic circuits and systems which have potential utility outside the aerospace community. Topics discussed include circuit components such as filters, converters, and integrators, circuits designed for use with specific equipment or systems, and circuits designed primarily for use with optical equipment or displays.

  3. Optical XOR circuit using combined technology of photonics and electronics

    NASA Astrophysics Data System (ADS)

    Takiguchi, Koichi

    2013-12-01

    I propose and demonstrate a novel and simple optical exclusive OR circuit for binary signals, which is composed of a balanced photo-detector and a Mach-Zehnder intensity modulator. Two input optical signals into the photo-detector produce an electrical signal to drive the modulator. The modulator outputs an optical exclusive OR signal of the two input optical signals. I report the configuration, operating principle, and primary experimental results using 10 Gbit/s binary signals to demonstrate that the exclusive OR circuit operates properly. The proposed simple circuit is suitable for the future hybrid integration of photonics and electronics.

  4. Positive fractional linear electrical circuits

    NASA Astrophysics Data System (ADS)

    Kaczorek, Tadeusz

    2013-10-01

    The positive fractional linear systems and electrical circuits are addressed. New classes of fractional asymptotically stable and unstable electrical circuits are introduced. The Caputo and Riemann-Liouville definitions of fractional derivatives are used to analysis of the positive electrical circuits composed of resistors, capacitors, coils and voltage (current) sources. The positive fractional electrical and specially unstable different types electrical circuits are analyzed. Some open problems are formulated.

  5. Methods of fabricating applique circuits

    DOEpatents

    Dimos, Duane B.; Garino, Terry J.

    1999-09-14

    Applique circuits suitable for advanced packaging applications are introduced. These structures are particularly suited for the simple integration of large amounts (many nanoFarads) of capacitance into conventional integrated circuit and multichip packaging technology. In operation, applique circuits are bonded to the integrated circuit or other appropriate structure at the point where the capacitance is required, thereby minimizing the effects of parasitic coupling. An immediate application is to problems of noise reduction and control in modern high-frequency circuitry.

  6. Experimental determination of circuit equations

    NASA Astrophysics Data System (ADS)

    Shulman, Jason; Malatino, Frank; Widjaja, Matthew; Gunaratne, Gemunu H.

    2015-01-01

    Kirchhoff's laws offer a general, straightforward approach to circuit analysis. Unfortunately, their application becomes impractical for all but the simplest of circuits. This work presents an alternative procedure, based on an approach developed to analyze complex networks, thus making it appropriate for use on large, complicated circuits. The procedure is unusual in that it is not an analytic method but is based on experiment. Yet, this approach produces the same circuit equations obtained by more traditional means.

  7. Statistical circuit design for yield improvement in CMOS circuits

    NASA Technical Reports Server (NTRS)

    Kamath, H. J.; Purviance, J. E.; Whitaker, S. R.

    1990-01-01

    This paper addresses the statistical design of CMOS integrated circuits for improved parametric yield. The work uses the Monte Carlo technique of circuit simulation to obtain an unbiased estimation of the yield. A simple graphical analysis tool, the yield factor histogram, is presented. The yield factor histograms are generated by a new computer program called SPICENTER. Using the yield factor histograms, the most sensitive circuit parameters are noted, and their nominal values are changed to improve the yield. Two basic CMOS example circuits, one analog and one digital, are chosen and their designs are 'centered' to illustrate the use of the yield factor histograms for statistical circuit design.

  8. High voltage MOSFET switching circuit

    DOEpatents

    McEwan, T.E.

    1994-07-26

    The problem of source lead inductance in a MOSFET switching circuit is compensated for by adding an inductor to the gate circuit. The gate circuit inductor produces an inductive spike which counters the source lead inductive drop to produce a rectangular drive voltage waveform at the internal gate-source terminals of the MOSFET. 2 figs.

  9. Ladder-Type Circuits Revisited

    ERIC Educational Resources Information Center

    Yoon, Sung Hyun

    2007-01-01

    Ladder-type circuits where a given unit is repeated infinitely many times are dealt with in many textbooks on electromagnetism as examples of filter circuits. Determining the impedance of such circuits seems to be regarded as simple, which may be due to the fact that the invariance of the infinite system under the operation of adding one more unit…

  10. High voltage MOSFET switching circuit

    DOEpatents

    McEwan, Thomas E.

    1994-01-01

    The problem of source lead inductance in a MOSFET switching circuit is compensated for by adding an inductor to the gate circuit. The gate circuit inductor produces an inductive spike which counters the source lead inductive drop to produce a rectangular drive voltage waveform at the internal gate-source terminals of the MOSFET.

  11. Power supply conditioning circuit

    NASA Technical Reports Server (NTRS)

    Primas, L. E.; Loveland, R.

    1987-01-01

    A power supply conditioning circuit that can reduce Periodic and Random Deviations (PARD) on the output voltages of dc power supplies to -150 dBV from dc to several KHz with no measurable periodic deviations is described. The PARD for a typical commercial low noise power supply is -74 dBV for frequencies above 20 Hz and is often much worse at frequencies below 20 Hz. The power supply conditioning circuit described here relies on the large differences in the dynamic impedances of a constant current diode and a zener diode to establish a dc voltage with low PARD. Power supplies with low PARD are especially important in circuitry involving ultrastable frequencies for the Deep Space Network.

  12. Neuromorphic Silicon Neuron Circuits

    PubMed Central

    Indiveri, Giacomo; Linares-Barranco, Bernabé; Hamilton, Tara Julia; van Schaik, André; Etienne-Cummings, Ralph; Delbruck, Tobi; Liu, Shih-Chii; Dudek, Piotr; Häfliger, Philipp; Renaud, Sylvie; Schemmel, Johannes; Cauwenberghs, Gert; Arthur, John; Hynna, Kai; Folowosele, Fopefolu; Saighi, Sylvain; Serrano-Gotarredona, Teresa; Wijekoon, Jayawan; Wang, Yingxue; Boahen, Kwabena

    2011-01-01

    Hardware implementations of spiking neurons can be extremely useful for a large variety of applications, ranging from high-speed modeling of large-scale neural systems to real-time behaving systems, to bidirectional brain–machine interfaces. The specific circuit solutions used to implement silicon neurons depend on the application requirements. In this paper we describe the most common building blocks and techniques used to implement these circuits, and present an overview of a wide range of neuromorphic silicon neurons, which implement different computational models, ranging from biophysically realistic and conductance-based Hodgkin–Huxley models to bi-dimensional generalized adaptive integrate and fire models. We compare the different design methodologies used for each silicon neuron design described, and demonstrate their features with experimental results, measured from a wide range of fabricated VLSI chips. PMID:21747754

  13. Engineered gene circuits

    NASA Astrophysics Data System (ADS)

    Hasty, Jeff; McMillen, David; Collins, J. J.

    2002-11-01

    A central focus of postgenomic research will be to understand how cellular phenomena arise from the connectivity of genes and proteins. This connectivity generates molecular network diagrams that resemble complex electrical circuits, and a systematic understanding will require the development of a mathematical framework for describing the circuitry. From an engineering perspective, the natural path towards such a framework is the construction and analysis of the underlying submodules that constitute the network. Recent experimental advances in both sequencing and genetic engineering have made this approach feasible through the design and implementation of synthetic gene networks amenable to mathematical modelling and quantitative analysis. These developments have signalled the emergence of a gene circuit discipline, which provides a framework for predicting and evaluating the dynamics of cellular processes. Synthetic gene networks will also lead to new logical forms of cellular control, which could have important applications in functional genomics, nanotechnology, and gene and cell therapy.

  14. PHASE DIFFERENTIAL INDICATING CIRCUIT

    DOEpatents

    Kirsten, F.A.

    1962-01-01

    An electronic circuit for totalizing the net phase difference between two alternating current signals is designed which responds to both increasing and decreasing phase changes. A phase comparator provldes an output pulse for each 360 deg of phase difference occurring, there being a negative pulse for phase shtft in one direction and a positive pulse for a phase shift in the opposite direction. A counting circuit utilizing glow discharge tubes receives the negative and positive pulses at a single input terminal and provides a running net total, pulses of one polarity dded and pulses of the opposite polarity being subtracted. The glow discharge tubes may be decaded to increase the total count capacity. (AEC)

  15. GAS PHOTOTUBE CIRCUIT

    DOEpatents

    Richardson, J.H.

    1958-03-01

    This patent pertains to electronic circuits for measuring the intensity of light and is especially concerned with measurement between preset light thresholds. Such a circuit has application in connection with devices for reading-out information stored on punch cards or tapes where the cards and tapes are translucent. By the novel arrangement of this invention thc sensitivity of a gas phototube is maintained at a low value when the light intensity is below a first threshold level. If the light level rises above the first threshold level, the tube is rendered highly sensitive and an output signal will vary in proportion to the light intensity change. When the light level decreases below a second threshold level, the gas phototube is automatically rendered highly insensitive. Each of these threshold points is adjustable.

  16. Integrated Circuit Immunity

    NASA Technical Reports Server (NTRS)

    Sketoe, J. G.; Clark, Anthony

    2000-01-01

    This paper presents a DOD E3 program overview on integrated circuit immunity. The topics include: 1) EMI Immunity Testing; 2) Threshold Definition; 3) Bias Tee Function; 4) Bias Tee Calibration Set-Up; 5) EDM Test Figure; 6) EMI Immunity Levels; 7) NAND vs. and Gate Immunity; 8) TTL vs. LS Immunity Levels; 9) TP vs. OC Immunity Levels; 10) 7805 Volt Reg Immunity; and 11) Seventies Chip Set. This paper is presented in viewgraph form.

  17. Cartography of serotonergic circuits

    PubMed Central

    Sparta, Dennis R.; Stuber, Garret D.

    2014-01-01

    Summary Serotonin is an essential neuromodulator, but the precise circuit connectivity that regulates serotonergic neurons has not been well defined. Using rabies virus tracing strategies Weissbourd et al., and Dorocic et al., in this issue of Neuron and Ogawa et al., in Cell Reports provide a comprehensive map of the inputs to serotonergic neurons; highlighting the complexity and diversity of potential upstream cellular regulators. PMID:25102556

  18. Cartography of serotonergic circuits.

    PubMed

    Sparta, Dennis R; Stuber, Garret D

    2014-08-01

    Serotonin is an essential neuromodulator, but the precise circuit connectivity that regulates serotonergic neurons has not been well defined. Using rabies virus tracing strategies Weissbourd et al. (2014) and Pollak Dorocic et al. (2014) in this issue of Neuron and Ogawa et al. (2014) in Cell Reports provide a comprehensive map of the inputs to serotonergic neurons, highlighting the complexity and diversity of potential upstream cellular regulators.

  19. Monolithic Optoelectronic Integrated Circuit

    NASA Technical Reports Server (NTRS)

    Bhasin, Kul B.; Walters, Wayne; Gustafsen, Jerry; Bendett, Mark

    1990-01-01

    Monolithic optoelectronic integrated circuit (OEIC) receives single digitally modulated input light signal via optical fiber and converts it into 16-channel electrical output signal. Potentially useful in any system in which digital data must be transmitted serially at high rates, then decoded into and used in parallel format at destination. Applications include transmission and decoding of control signals to phase shifters in phased-array antennas and also communication of data between computers and peripheral equipment in local-area networks.

  20. PARTICLE BEAM TRACKING CIRCUIT

    DOEpatents

    Anderson, O.A.

    1959-05-01

    >A particle-beam tracking and correcting circuit is described. Beam induction electrodes are placed on either side of the beam, and potentials induced by the beam are compared in a voltage comparator or discriminator. This comparison produces an error signal which modifies the fm curve at the voltage applied to the drift tube, thereby returning the orbit to the preferred position. The arrangement serves also to synchronize accelerating frequency and magnetic field growth. (T.R.H.)

  1. Electrochemical Circuit Elements.

    PubMed

    Maier, Joachim

    2016-01-01

    The vast majority of electrochemical processes can be modelled by resistors and capacitors. These will then be, in addition to usual circuit elements, electrochemical and chemical resistors or chemical capacitors. The paper shows the significance of understanding these parameters and their connections in given systems for a variety of timely scientific examples. This rationale mirrors one of the intellectual facets, if not the most important one, of Janko Jamnik's scientific work. PMID:27640384

  2. Optical Circuit Switched Protocol

    NASA Technical Reports Server (NTRS)

    Monacos, Steve P. (Inventor)

    2000-01-01

    The present invention is a system and method embodied in an optical circuit switched protocol for the transmission of data through a network. The optical circuit switched protocol is an all-optical circuit switched network and includes novel optical switching nodes for transmitting optical data packets within a network. Each optical switching node comprises a detector for receiving the header, header detection logic for translating the header into routing information and eliminating the header, and a controller for receiving the routing information and configuring an all optical path within the node. The all optical path located within the node is solely an optical path without having electronic storage of the data and without having optical delay of the data. Since electronic storage of the header is not necessary and the initial header is eliminated by the first detector of the first switching node. multiple identical headers are sent throughout the network so that subsequent switching nodes can receive and read the header for setting up an optical data path.

  3. Inkjet deposited circuit components

    NASA Astrophysics Data System (ADS)

    Bidoki, S. M.; Nouri, J.; Heidari, A. A.

    2010-05-01

    All-printed electronics as a means of achieving ultra-low-cost electronic circuits has attracted great interest in recent years. Inkjet printing is one of the most promising techniques by which the circuit components can be ultimately drawn (i.e. printed) onto the substrate in one step. Here, the inkjet printing technique was used to chemically deposit silver nanoparticles (10-200 nm) simply by ejection of silver nitrate and reducing solutions onto different substrates such as paper, PET plastic film and textile fabrics. The silver patterns were tested for their functionality to work as circuit components like conductor, resistor, capacitor and inductor. Different levels of conductivity were achieved simply by changing the printing sequence, inks ratio and concentration. The highest level of conductivity achieved by an office thermal inkjet printer (300 dpi) was 5.54 × 105 S m-1 on paper. Inkjet deposited capacitors could exhibit a capacitance of more than 1.5 nF (parallel plate 45 × 45 mm2) and induction coils displayed an inductance of around 400 µH (planar coil 10 cm in diameter). Comparison of electronic performance of inkjet deposited components to the performance of conventionally etched items makes the technique highly promising for fabricating different printed electronic devices.

  4. Driven superconducting quantum circuits

    NASA Astrophysics Data System (ADS)

    Nakamura, Yasunobu

    2014-03-01

    Driven nonlinear quantum systems show rich phenomena in various fields of physics. Among them, superconducting quantum circuits have very attractive features such as well-controlled quantum states with design flexibility, strong nonlinearity of Josephson junctions, strong coupling to electromagnetic driving fields, little internal dissipation, and tailored coupling to the electromagnetic environment. We have investigated properties and functionalities of driven superconducting quantum circuits. A transmon qubit coupled to a transmission line shows nearly perfect spatial mode matching between the incident and scattered microwave field in the 1D mode. Dressed states under a driving field are studied there and also in a semi-infinite 1D mode terminated by a resonator containing a flux qubit. An effective Λ-type three-level system is realized under an appropriate driving condition. It allows ``impedance-matched'' perfect absorption of incident probe photons and down conversion into another frequency mode. Finally, the weak signal from the qubit is read out using a Josephson parametric amplifier/oscillator which is another nonlinear circuit driven by a strong pump field. This work was partly supported by the Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST), Project for Developing Innovation Systems of MEXT, MEXT KAKENHI ``Quantum Cybernetics,'' and the NICT Commissioned Research.

  5. Interface Circuit For Printer Port

    NASA Technical Reports Server (NTRS)

    Tucker, Jerry H.; Yadlowsky, Ann B.

    1991-01-01

    Electronic circuit, called printer-port interface circuit (PPI) developed to overcome certain disadvantages of previous methods for connecting IBM PC or PC-compatible computer to other equipment. Has both reading and writing modes of operation. Very simple, requiring only six integrated circuits. Provides for moderately fast rates of transfer of data and uses existing unmodified circuit card in IBM PC. When used with appropriate software, circuit converts printer port on IBM PC, XT, AT, or compatible personal computer to general purpose, 8-bit-data, 16-bit address bus that connects to multitude of devices.

  6. Power system with an integrated lubrication circuit

    DOEpatents

    Hoff, Brian D.; Akasam, Sivaprasad; Algrain, Marcelo C.; Johnson, Kris W.; Lane, William H.

    2009-11-10

    A power system includes an engine having a first lubrication circuit and at least one auxiliary power unit having a second lubrication circuit. The first lubrication circuit is in fluid communication with the second lubrication circuit.

  7. Memristor based startup circuit for self biased circuits

    NASA Astrophysics Data System (ADS)

    Das, Mangal; Singh, Amit Kumar; Rathi, Amit; Singhal, Sonal

    2016-04-01

    This paper presents the design of a Memristor based startup circuit for self biased circuits. Memristor has many advantages over conventional CMOS devices such as low leakage current at nanometer scale, easy to manufacture. In this work the switching characteristics of memristor is utilized. First the theoretical equations describing the switching behavior of memristor are investigated. To prove the switching capability of Memristor, a startup circuit based on memristor is proposed which uses series combination of Memristor and capacitor. Proposed circuit is compared with the previously reported MOSFET based startup circuits. Comparison of different circuits was done to validate the results. Simulation results show that memristor based circuit can attain on (I = 12.94 µA) to off state (I = 1 .2 µA) in 25 ns while the MOSFET based startup circuits take on (I = 14.19 µA) to off state (I = 1.4 µA) in more than 90 ns. The benefit comes in terms of area because the number of components used in the circuit are lesser than the conventional startup circuits.

  8. Climate change and its impacts on vegetation distribution and net primary productivity of the alpine ecosystem in the Qinghai-Tibetan Plateau.

    PubMed

    Gao, Qingzhu; Guo, Yaqi; Xu, Hongmei; Ganjurjav, Hasbagen; Li, Yue; Wan, Yunfan; Qin, Xiaobo; Ma, Xin; Liu, Shuo

    2016-06-01

    Changes in climate have caused impacts on ecosystems on all continents scale, and climate change is also projected to be a stressor on most ecosystems even at the rate of low- to medium-range warming scenarios. Alpine ecosystem in the Qinghai-Tibetan Plateau is vulnerable to climate change. To quantify the climate change impacts on alpine ecosystems, we simulated the vegetation distribution and net primary production in the Qinghai-Tibetan Plateau for three future periods (2020s, 2050s and 2080s) using climate projection for RCPs (Representative Concentration Pathways) RCP4.5 and RCP8.5 scenarios. The modified Lund-Potsdam-Jena Dynamic Global Vegetation Model (LPJ model) was parameter and test to make it applicable to the Qinghai-Tibetan Plateau. Climate projections that were applied to LPJ model in the Qinghai-Tibetan Plateau showed trends toward warmer and wetter conditions. Results based on climate projections indicated changes from 1.3°C to 4.2°C in annual temperature and changes from 2% to 5% in annual precipitation. The main impacts on vegetation distribution was increase in the area of forests and shrubs, decrease in alpine meadows which mainly replaced by shrubs which dominated the eastern plateau, and expanding in alpine steppes to the northwest dominated the western and northern plateau. The NPP was projected to increase by 79% and 134% under the RCP4.5 and RCP8.5. The projected NPP generally increased about 200gC·m(-2)·yr(-1) in most parts of the plateau with a gradual increase from the eastern to the western region of the Qinghai-Tibetan Plateau at the end of this century.

  9. Climate change and its impacts on vegetation distribution and net primary productivity of the alpine ecosystem in the Qinghai-Tibetan Plateau.

    PubMed

    Gao, Qingzhu; Guo, Yaqi; Xu, Hongmei; Ganjurjav, Hasbagen; Li, Yue; Wan, Yunfan; Qin, Xiaobo; Ma, Xin; Liu, Shuo

    2016-06-01

    Changes in climate have caused impacts on ecosystems on all continents scale, and climate change is also projected to be a stressor on most ecosystems even at the rate of low- to medium-range warming scenarios. Alpine ecosystem in the Qinghai-Tibetan Plateau is vulnerable to climate change. To quantify the climate change impacts on alpine ecosystems, we simulated the vegetation distribution and net primary production in the Qinghai-Tibetan Plateau for three future periods (2020s, 2050s and 2080s) using climate projection for RCPs (Representative Concentration Pathways) RCP4.5 and RCP8.5 scenarios. The modified Lund-Potsdam-Jena Dynamic Global Vegetation Model (LPJ model) was parameter and test to make it applicable to the Qinghai-Tibetan Plateau. Climate projections that were applied to LPJ model in the Qinghai-Tibetan Plateau showed trends toward warmer and wetter conditions. Results based on climate projections indicated changes from 1.3°C to 4.2°C in annual temperature and changes from 2% to 5% in annual precipitation. The main impacts on vegetation distribution was increase in the area of forests and shrubs, decrease in alpine meadows which mainly replaced by shrubs which dominated the eastern plateau, and expanding in alpine steppes to the northwest dominated the western and northern plateau. The NPP was projected to increase by 79% and 134% under the RCP4.5 and RCP8.5. The projected NPP generally increased about 200gC·m(-2)·yr(-1) in most parts of the plateau with a gradual increase from the eastern to the western region of the Qinghai-Tibetan Plateau at the end of this century. PMID:26950617

  10. Teaching Electricity Effectively in the Primary School: A Case Study.

    ERIC Educational Resources Information Center

    Summers, Mike; Kruger, Colin; Mant, Jenny

    1998-01-01

    Identifies subject and teaching knowledge that primary school teachers can use to effectively develop children's understanding of electricity and simple circuits. Presents a set of electricity concepts that are appropriate for primary children to explore. Contains 19 references. (DDR)

  11. Detailed Analysis of the Transient Voltage in a JT-60SA PF Coil Circuit

    NASA Astrophysics Data System (ADS)

    Yamauchi, K.; Shimada, K.; Terakado, T.; Matsukawa, M.; Coletti, R.; Lampasi, A.; Gaio, E.; Coletti, A.; Novello, L.

    2013-02-01

    A superconducting coil system is actually complicated by the distributed parameters, e.g. the distributed mutual inductance among turns and the distributed capacitance between adjacent conductors. In this paper, such a complicated system was modeled with a reasonably simplified circuit network with lumped parameters. Then, a detailed circuit analysis was conducted to evaluate the possible voltage transient in the coil circuit. As a result, an appropriate (minimum) snubber capacitance for the Switching Network Unit, which is a fast high voltage generation circuit in JT-60SA, was obtained.

  12. Analysis of the human brain in primary progressive multiple sclerosis with mapping of the spatial distributions using 1H MR spectroscopy and diffusion tensor imaging.

    PubMed

    Sijens, Paul E; Irwan, Roy; Potze, Jan Hendrik; Mostert, Jop P; De Keyser, Jacques; Oudkerk, Matthijs

    2005-08-01

    Primary progressive multiple sclerosis (ppMS; n=4) patients and controls (n=4) were examined by 1H magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) in order to map choline (Cho), creatine and N-acetylaspartate (NAA), the fractional anisotropy (FA) and the apparent diffusion constant (ADC). After chemical shift imaging (point-resolved spectroscopy, repetition time/echo time 1,500 ms/135 ms) of a supraventricular volume of interest of 8x8x2 cm3 (64 voxels) MRS peak areas were matched to the results of DTI for the corresponding volume elements. Mean FA and NAA values were reduced in the ppMS patients (P<0.01, both) and the ADC increased (P<0.02). The spatial distribution of NAA showed strong correlation to ADC in both ppMS patients and controls (r =-0.74 and r= -0.70; P<0.00001, both), and weaker correlations to FA (r=0.49 and r=0.41; P<0.00001, all). FA and ADC also correlated significantly with Cho in patients and controls (P<0.00001, all). The relationship of Cho and NAA to the ADC and the FA and thus to the content of neuronal structures suggests that these metabolite signals essentially originate from axons (NAA) and the myelin sheath (Cho). This is of interest in view of previous reports in which Cho increases were associated with demyelination and the subsequent breakdown of neurons.

  13. Base drive circuit

    DOEpatents

    Lange, Arnold C.

    1995-01-01

    An improved base drive circuit (10) having a level shifter (24) for providing bistable input signals to a pair of non-linear delays (30, 32). The non-linear delays (30, 32) provide gate control to a corresponding pair of field effect transistors (100, 106) through a corresponding pair of buffer components (88, 94). The non-linear delays (30, 32) provide delayed turn-on for each of the field effect transistors (100, 106) while an associated pair of transistors (72, 80) shunt the non-linear delays (30, 32) during turn-off of the associated field effect transistor (100, 106).

  14. Dynamic pulse difference circuit

    DOEpatents

    Erickson, Gerald L.

    1978-01-01

    A digital electronic circuit of especial use for subtracting background activity pulses in gamma spectrometry comprises an up-down counter connected to count up with signal-channel pulses and to count down with background-channel pulses. A detector responsive to the count position of the up-down counter provides a signal when the up-down counter has completed one scaling sequence cycle of counts in the up direction. In an alternate embodiment, a detector responsive to the count position of the up-down counter provides a signal upon overflow of the counter.

  15. Seeing Circuits Assemble

    PubMed Central

    Lichtman, Jeff W.; Smith, Stephen J.

    2009-01-01

    Developmental neurobiology has been greatly invigorated by a recent string of breakthroughs in molecular biology and optical physics that permit direct in vivo observation of neural circuit assembly. The imaging done thus far suggests that as brains are built, a significant amount of unbuilding is also occurring. We offer the view that this tumult is the result of the intersecting behaviors of the many single-celled creatures (i.e., neurons, glia, and progenitors) that inhabit brains. New tools will certainly be needed if we wish to monitor the myriad cooperative and competitive interactions at play in the cellular society that builds brains. PMID:18995818

  16. Integrated circuit cell library

    NASA Technical Reports Server (NTRS)

    Whitaker, Sterling R. (Inventor); Miles, Lowell H. (Inventor)

    2005-01-01

    According to the invention, an ASIC cell library for use in creation of custom integrated circuits is disclosed. The ASIC cell library includes some first cells and some second cells. Each of the second cells includes two or more kernel cells. The ASIC cell library is at least 5% comprised of second cells. In various embodiments, the ASIC cell library could be 10% or more, 20% or more, 30% or more, 40% or more, 50% or more, 60% or more, 70% or more, 80% or more, 90% or more, or 95% or more comprised of second cells.

  17. Photonic Integrated Circuits

    NASA Technical Reports Server (NTRS)

    Merritt, Scott; Krainak, Michael

    2016-01-01

    Integrated photonics generally is the integration of multiple lithographically defined photonic and electronic components and devices (e.g. lasers, detectors, waveguides passive structures, modulators, electronic control and optical interconnects) on a single platform with nanometer-scale feature sizes. The development of photonic integrated circuits permits size, weight, power and cost reductions for spacecraft microprocessors, optical communication, processor buses, advanced data processing, and integrated optic science instrument optical systems, subsystems and components. This is particularly critical for small spacecraft platforms. We will give an overview of some NASA applications for integrated photonics.

  18. Base drive circuit

    DOEpatents

    Lange, A.C.

    1995-04-04

    An improved base drive circuit having a level shifter for providing bistable input signals to a pair of non-linear delays. The non-linear delays provide gate control to a corresponding pair of field effect transistors through a corresponding pair of buffer components. The non-linear delays provide delayed turn-on for each of the field effect transistors while an associated pair of transistors shunt the non-linear delays during turn-off of the associated field effect transistor. 2 figures.

  19. Handshake circuits: An intermediary between communicating processes and VLSI

    NASA Astrophysics Data System (ADS)

    Vanberkel, Cornelis Hermanus

    Tangram and handshake circuits are introduced. The cost and performance of the circuits is the primary concern, as they make Very Large Scale Integration (VLSI) programming different from (and also more difficult than) traditional computer programming. The theory for handshake circuits makes up the body of the thesis. The key motion is that of the handshake process. A handshake process is a mathematical object that describes a handshake communication behavior. This handshake behavior may be that of the components of a handshake circuit. A handshake circuit is a set of handshake processes that satisfy a simple compositional rule. The behavior of the handshake circuit is defined through parallel composition of its constituents components and is, again, a handshake process. In appendix A, the delay insensitivity of handshake circuits is related to the theory reported in the literature. A calculus for handshake processes is developed. This calculus allows concise descriptions of behaviors of handshake components. A precise definition of Tangram is given. For a subset of Tangram, which we call Core Tangram, a formal denotation 'H' is given in terms of handshake processes. In appendix B, a link to the well known failure semantics of CSP (Communication Sequential Processes) is established. The translation of Tangram programs into handshake circuits by means of the mathematical function 'C' is described. For Core Tangram it is proven that the behavior of the compiled handshake circuit is equivalent to that of the original program in a well defined sense. The realization of handshake circuits in VLSI is considered. Issues such as peephole optimization, handshake refinement, data encoding, decompositions into VLSI operator networks, initialization, and testing are discussed.

  20. Optically controllable molecular logic circuits

    SciTech Connect

    Nishimura, Takahiro Fujii, Ryo; Ogura, Yusuke; Tanida, Jun

    2015-07-06

    Molecular logic circuits represent a promising technology for observation and manipulation of biological systems at the molecular level. However, the implementation of molecular logic circuits for temporal and programmable operation remains challenging. In this paper, we demonstrate an optically controllable logic circuit that uses fluorescence resonance energy transfer (FRET) for signaling. The FRET-based signaling process is modulated by both molecular and optical inputs. Based on the distance dependence of FRET, the FRET pathways required to execute molecular logic operations are formed on a DNA nanostructure as a circuit based on its molecular inputs. In addition, the FRET pathways on the DNA nanostructure are controlled optically, using photoswitching fluorescent molecules to instruct the execution of the desired operation and the related timings. The behavior of the circuit can thus be controlled using external optical signals. As an example, a molecular logic circuit capable of executing two different logic operations was studied. The circuit contains functional DNAs and a DNA scaffold to construct two FRET routes for executing Input 1 AND Input 2 and Input 1 AND NOT Input 3 operations on molecular inputs. The circuit produced the correct outputs with all possible combinations of the inputs by following the light signals. Moreover, the operation execution timings were controlled based on light irradiation and the circuit responded to time-dependent inputs. The experimental results demonstrate that the circuit changes the output for the required operations following the input of temporal light signals.

  1. Establishing the Relationship between Fracture-Related Dolomite and Primary Rock Fabric on the Distribution of Reservoirs in the Michigan Basin

    SciTech Connect

    G. Michael Grammer

    2006-09-30

    This topical report covers the year 2 of the subject 3-year grant, evaluating the relationship between fracture-related dolomite and dolomite constrained by primary rock fabric in the 3 most prolific reservoir intervals in the Michigan Basin (Ordovician Trenton-Black River Formations; Silurian Niagara Group; and the Devonian Dundee Formation). The characterization of select dolomite reservoirs has been the major focus of our efforts in Phase II/Year 2. Fields have been prioritized based upon the availability of rock data for interpretation of depositional environments, fracture density and distribution as well as thin section, geochemical, and petrophysical analyses. Structural mapping and log analysis in the Dundee (Devonian) and Trenton/Black River (Ordovician) suggest a close spatial relationship among gross dolomite distribution and regional-scale, wrench fault related NW-SE and NE-SW structural trends. A high temperature origin for much of the dolomite in the 3 studied intervals (based upon initial fluid inclusion homogenization temperatures and stable isotopic analyses,) coupled with persistent association of this dolomite in reservoirs coincident with wrench fault-related features, is strong evidence for these reservoirs being influenced by hydrothermal dolomitization. For the Niagaran (Silurian), a comprehensive high resolution sequence stratigraphic framework has been developed for a pinnacle reef in the northern reef trend where we had 100% core coverage throughout the reef section. Major findings to date are that facies types, when analyzed at a detailed level, have direct links to reservoir porosity and permeability in these dolomites. This pattern is consistent with our original hypothesis of primary facies control on dolomitization and resulting reservoir quality at some level. The identification of distinct and predictable vertical stacking patterns within a hierarchical sequence and cycle framework provides a high degree of confidence at this point

  2. Partitioning structural VHDL circuits for parallel execution on hypercubes

    NASA Astrophysics Data System (ADS)

    Kapp, Kevin L.

    1993-12-01

    Distributing simulations among multiple processors is one approach to reducing VHDL simulation time for large VLSI circuit designs. However, parallel simulation introduces the problem of how to partition the logic gates and system behaviors among the available processors in order to obtain maximum speedup. This research investigates deliberate partitioning algorithms that account for the complex inter-dependency structure of the circuit behaviors. Once an initial partition has been obtained, a border annealing algorithm is used to iteratively improve the partition. In addition, methods of measuring the cost of a partition and relating it to the resulting simulation performance are investigated. Structural circuits ranging from one thousand to over four thousand behaviors are simulated. The deliberate partitions consistently provided superior speedup to a random distribution of the circuit behaviors.

  3. Sequential circuit design for radiation hardened multiple voltage integrated circuits

    SciTech Connect

    Clark, Lawrence T.; McIver, III, John K.

    2009-11-24

    The present invention includes a radiation hardened sequential circuit, such as a bistable circuit, flip-flop or other suitable design that presents substantial immunity to ionizing radiation while simultaneously maintaining a low operating voltage. In one embodiment, the circuit includes a plurality of logic elements that operate on relatively low voltage, and a master and slave latches each having storage elements that operate on a relatively high voltage.

  4. PCSIM: A Parallel Simulation Environment for Neural Circuits Fully Integrated with Python

    PubMed Central

    Pecevski, Dejan; Natschläger, Thomas; Schuch, Klaus

    2008-01-01

    The Parallel Circuit SIMulator (PCSIM) is a software package for simulation of neural circuits. It is primarily designed for distributed simulation of large scale networks of spiking point neurons. Although its computational core is written in C++, PCSIM's primary interface is implemented in the Python programming language, which is a powerful programming environment and allows the user to easily integrate the neural circuit simulator with data analysis and visualization tools to manage the full neural modeling life cycle. The main focus of this paper is to describe PCSIM's full integration into Python and the benefits thereof. In particular we will investigate how the automatically generated bidirectional interface and PCSIM's object-oriented modular framework enable the user to adopt a hybrid modeling approach: using and extending PCSIM's functionality either employing pure Python or C++ and thus combining the advantages of both worlds. Furthermore, we describe several supplementary PCSIM packages written in pure Python and tailored towards setting up and analyzing neural simulations. PMID:19543450

  5. Quasi-Linear Circuit

    NASA Technical Reports Server (NTRS)

    Bradley, William; Bird, Ross; Eldred, Dennis; Zook, Jon; Knowles, Gareth

    2013-01-01

    This work involved developing spacequalifiable switch mode DC/DC power supplies that improve performance with fewer components, and result in elimination of digital components and reduction in magnetics. This design is for missions where systems may be operating under extreme conditions, especially at elevated temperature levels from 200 to 300 degC. Prior art for radiation-tolerant DC/DC converters has been accomplished utilizing classical magnetic-based switch mode converter topologies; however, this requires specific shielding and component de-rating to meet the high-reliability specifications. It requires complex measurement and feedback components, and will not enable automatic re-optimization for larger changes in voltage supply or electrical loading condition. The innovation is a switch mode DC/DC power supply that eliminates the need for processors and most magnetics. It can provide a well-regulated voltage supply with a gain of 1:100 step-up to 8:1 step down, tolerating an up to 30% fluctuation of the voltage supply parameters. The circuit incorporates a ceramic core transformer in a manner that enables it to provide a well-regulated voltage output without use of any processor components or magnetic transformers. The circuit adjusts its internal parameters to re-optimize its performance for changes in supply voltage, environmental conditions, or electrical loading at the output

  6. Time in Cortical Circuits

    PubMed Central

    Shadlen, Michael N.; Jazayeri, Mehrdad; Nobre, Anna C.; Buonomano, Dean V.

    2015-01-01

    Time is central to cognition. However, the neural basis for time-dependent cognition remains poorly understood. We explore how the temporal features of neural activity in cortical circuits and their capacity for plasticity can contribute to time-dependent cognition over short time scales. This neural activity is linked to cognition that operates in the present or anticipates events or stimuli in the near future. We focus on deliberation and planning in the context of decision making as a cognitive process that integrates information across time. We progress to consider how temporal expectations of the future modulate perception. We propose that understanding the neural basis for how the brain tells time and operates in time will be necessary to develop general models of cognition. SIGNIFICANCE STATEMENT Time is central to cognition. However, the neural basis for time-dependent cognition remains poorly understood. We explore how the temporal features of neural activity in cortical circuits and their capacity for plasticity can contribute to time-dependent cognition over short time scales. We propose that understanding the neural basis for how the brain tells time and operates in time will be necessary to develop general models of cognition. PMID:26468192

  7. Jitter compensation circuit

    DOEpatents

    Sullivan, J.S.; Ball, D.G.

    1997-09-09

    The instantaneous V{sub co} signal on a charging capacitor is sampled and the charge voltage on capacitor C{sub o} is captured just prior to its discharge into the first stage of magnetic modulator. The captured signal is applied to an averaging circuit with a long time constant and to the positive input terminal of a differential amplifier. The averaged V{sub co} signal is split between a gain stage (G = 0.975) and a feedback stage that determines the slope of the voltage ramp applied to the high speed comparator. The 97.5% portion of the averaged V{sub co} signal is applied to the negative input of a differential amplifier gain stage (G = 10). The differential amplifier produces an error signal by subtracting 97.5% of the averaged V{sub co} signal from the instantaneous value of sampled V{sub co} signal and multiplying the difference by ten. The resulting error signal is applied to the positive input of a high speed comparator. The error signal is then compared to a voltage ramp that is proportional to the averaged V{sub co} values squared divided by the total volt-second product of the magnetic compression circuit. 11 figs.

  8. Jitter compensation circuit

    DOEpatents

    Sullivan, James S.; Ball, Don G.

    1997-01-01

    The instantaneous V.sub.co signal on a charging capacitor is sampled and the charge voltage on capacitor C.sub.o is captured just prior to its discharge into the first stage of magnetic modulator. The captured signal is applied to an averaging circuit with a long time constant and to the positive input terminal of a differential amplifier. The averaged V.sub. co signal is split between a gain stage (G=0.975) and a feedback stage that determines the slope of the voltage ramp applied to the high speed comparator. The 97.5% portion of the averaged V.sub.co signal is applied to the negative input of a differential amplifier gain stage (G=10). The differential amplifier produces an error signal by subtracting 97.5% of the averaged V.sub.co signal from the instantaneous value of sampled V.sub.co signal and multiplying the difference by ten. The resulting error signal is applied to the positive input of a high speed comparator. The error signal is then compared to a voltage ramp that is proportional to the averaged V.sub.co values squared divided by the total volt-second product of the magnetic compression circuit.

  9. Simple Cell Balance Circuit

    NASA Technical Reports Server (NTRS)

    Johnson, Steven D.; Byers, Jerry W.; Martin, James A.

    2012-01-01

    A method has been developed for continuous cell voltage balancing for rechargeable batteries (e.g. lithium ion batteries). A resistor divider chain is provided that generates a set of voltages representing the ideal cell voltage (the voltage of each cell should be as if the cells were perfectly balanced). An operational amplifier circuit with an added current buffer stage generates the ideal voltage with a very high degree of accuracy, using the concept of negative feedback. The ideal voltages are each connected to the corresponding cell through a current- limiting resistance. Over time, having the cell connected to the ideal voltage provides a balancing current that moves the cell voltage very close to that ideal level. In effect, it adjusts the current of each cell during charging, discharging, and standby periods to force the cell voltages to be equal to the ideal voltages generated by the resistor divider. The device also includes solid-state switches that disconnect the circuit from the battery so that it will not discharge the battery during storage. This solution requires relatively few parts and is, therefore, of lower cost and of increased reliability due to the fewer failure modes. Additionally, this design uses very little power. A preliminary model predicts a power usage of 0.18 W for an 8-cell battery. This approach is applicable to a wide range of battery capacities and voltages.

  10. A bit serial sequential circuit

    NASA Technical Reports Server (NTRS)

    Hu, S.; Whitaker, S.

    1990-01-01

    Normally a sequential circuit with n state variables consists of n unique hardware realizations, one for each state variable. All variables are processed in parallel. This paper introduces a new sequential circuit architecture that allows the state variables to be realized in a serial manner using only one next state logic circuit. The action of processing the state variables in a serial manner has never been addressed before. This paper presents a general design procedure for circuit construction and initialization. Utilizing pass transistors to form the combinational next state forming logic in synchronous sequential machines, a bit serial state machine can be realized with a single NMOS pass transistor network connected to shift registers. The bit serial state machine occupies less area than other realizations which perform parallel operations. Moreover, the logical circuit of the bit serial state machine can be modified by simply changing the circuit input matrix to develop an adaptive state machine.

  11. Automated Design of Quantum Circuits

    NASA Technical Reports Server (NTRS)

    Williams, Colin P.; Gray, Alexander G.

    2000-01-01

    In order to design a quantum circuit that performs a desired quantum computation, it is necessary to find a decomposition of the unitary matrix that represents that computation in terms of a sequence of quantum gate operations. To date, such designs have either been found by hand or by exhaustive enumeration of all possible circuit topologies. In this paper we propose an automated approach to quantum circuit design using search heuristics based on principles abstracted from evolutionary genetics, i.e. using a genetic programming algorithm adapted specially for this problem. We demonstrate the method on the task of discovering quantum circuit designs for quantum teleportation. We show that to find a given known circuit design (one which was hand-crafted by a human), the method considers roughly an order of magnitude fewer designs than naive enumeration. In addition, the method finds novel circuit designs superior to those previously known.

  12. 49 CFR 236.13 - Spring switch; selection of signal control circuits through circuit controller.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... circuits through circuit controller. 236.13 Section 236.13 Transportation Other Regulations Relating to...; selection of signal control circuits through circuit controller. The control circuits of signals governing... circuit controller, or through the contacts of relay repeating the position of such circuit...

  13. 49 CFR 236.13 - Spring switch; selection of signal control circuits through circuit controller.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... circuits through circuit controller. 236.13 Section 236.13 Transportation Other Regulations Relating to...; selection of signal control circuits through circuit controller. The control circuits of signals governing... circuit controller, or through the contacts of relay repeating the position of such circuit...

  14. 49 CFR 236.13 - Spring switch; selection of signal control circuits through circuit controller.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... circuits through circuit controller. 236.13 Section 236.13 Transportation Other Regulations Relating to...; selection of signal control circuits through circuit controller. The control circuits of signals governing... circuit controller, or through the contacts of relay repeating the position of such circuit...

  15. 49 CFR 236.13 - Spring switch; selection of signal control circuits through circuit controller.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... circuits through circuit controller. 236.13 Section 236.13 Transportation Other Regulations Relating to...; selection of signal control circuits through circuit controller. The control circuits of signals governing... circuit controller, or through the contacts of relay repeating the position of such circuit...

  16. The defect-centric perspective of device and circuit reliability—From gate oxide defects to circuits

    NASA Astrophysics Data System (ADS)

    Kaczer, B.; Franco, J.; Weckx, P.; Roussel, Ph. J.; Simicic, M.; Putcha, V.; Bury, E.; Cho, M.; Degraeve, R.; Linten, D.; Groeseneken, G.; Debacker, P.; Parvais, B.; Raghavan, P.; Catthoor, F.; Rzepa, G.; Waltl, M.; Goes, W.; Grasser, T.

    2016-11-01

    As-fabricated (time-zero) variability and mean device aging are nowadays routinely considered in circuit simulations and design. Time-dependent variability (reliability-related variability) is an emerging concern that needs to be considered in circuit design as well. This phenomenon in deeply scaled devices can be best understood within the so-called defect-centric picture in terms of an ensemble of individual defects. The properties of gate oxide defects are discussed. It is further shown how in particular the electrical properties can be used to construct time-dependent variability distributions and can be propagated up to transistor-level circuits.

  17. Pharmacokinetics and RC Circuit Concepts

    NASA Astrophysics Data System (ADS)

    Cock, Mieke De; Janssen, Paul

    2013-11-01

    Most introductory physics courses include a chapter on RC circuits in which the differential equations for the charging and discharging of a capacitor are derived. A number of papers in this journal describe lab experiments dealing with the measurement of different parameters in such RC circuits. In this contribution, we report on a lab experiment we developed for students majoring in pharmacy, using RC circuits to simulate a pharmacokinetic process.

  18. Source-circuit design overview

    NASA Technical Reports Server (NTRS)

    Ross, R. G., Jr.

    1983-01-01

    The source circuit is the fundamental electrical building block of a large central-station array; it consists of a series-parallel network of solar cells that develops full system voltage. The array field is generally made up of a large number of parallel source circuits. Source-circuit electrical configuration is driven by a number of design considerations, which must be considered simultaneously. Array fault tolerance and hot spot heating endurance are examined in detail.

  19. Electronic control circuits: A compilation

    NASA Technical Reports Server (NTRS)

    1973-01-01

    A compilation of technical R and D information on circuits and modular subassemblies is presented as a part of a technology utilization program. Fundamental design principles and applications are given. Electronic control circuits discussed include: anti-noise circuit; ground protection device for bioinstrumentation; temperature compensation for operational amplifiers; hybrid gatling capacitor; automatic signal range control; integrated clock-switching control; and precision voltage tolerance detector.

  20. Magnetic compression laser driving circuit

    DOEpatents

    Ball, Don G.; Birx, Dan; Cook, Edward G.

    1993-01-01

    A magnetic compression laser driving circuit is disclosed. The magnetic compression laser driving circuit compresses voltage pulses in the range of 1.5 microseconds at 20 Kilovolts of amplitude to pulses in the range of 40 nanoseconds and 60 Kilovolts of amplitude. The magnetic compression laser driving circuit includes a multi-stage magnetic switch where the last stage includes a switch having at least two turns which has larger saturated inductance with less core material so that the efficiency of the circuit and hence the laser is increased.

  1. Four-junction superconducting circuit

    PubMed Central

    Qiu, Yueyin; Xiong, Wei; He, Xiao-Ling; Li, Tie-Fu; You, J. Q.

    2016-01-01

    We develop a theory for the quantum circuit consisting of a superconducting loop interrupted by four Josephson junctions and pierced by a magnetic flux (either static or time-dependent). In addition to the similarity with the typical three-junction flux qubit in the double-well regime, we demonstrate the difference of the four-junction circuit from its three-junction analogue, including its advantages over the latter. Moreover, the four-junction circuit in the single-well regime is also investigated. Our theory provides a tool to explore the physical properties of this four-junction superconducting circuit. PMID:27356619

  2. Magnetic compression laser driving circuit

    DOEpatents

    Ball, D.G.; Birx, D.; Cook, E.G.

    1993-01-05

    A magnetic compression laser driving circuit is disclosed. The magnetic compression laser driving circuit compresses voltage pulses in the range of 1.5 microseconds at 20 kilovolts of amplitude to pulses in the range of 40 nanoseconds and 60 kilovolts of amplitude. The magnetic compression laser driving circuit includes a multi-stage magnetic switch where the last stage includes a switch having at least two turns which has larger saturated inductance with less core material so that the efficiency of the circuit and hence the laser is increased.

  3. PRECISION TIME-DELAY CIRCUIT

    DOEpatents

    Creveling, R.

    1959-03-17

    A tine-delay circuit which produces a delay time in d. The circuit a capacitor, an te back resistance, connected serially with the anode of the diode going to ground. At the start of the time delay a negative stepfunction is applied to the series circuit and initiates a half-cycle transient oscillatory voltage terminated by a transient oscillatory voltage of substantially higher frequency. The output of the delay circuit is taken at the junction of the inductor and diode where a sudden voltage rise appears after the initiation of the higher frequency transient oscillations.

  4. Four-junction superconducting circuit.

    PubMed

    Qiu, Yueyin; Xiong, Wei; He, Xiao-Ling; Li, Tie-Fu; You, J Q

    2016-01-01

    We develop a theory for the quantum circuit consisting of a superconducting loop interrupted by four Josephson junctions and pierced by a magnetic flux (either static or time-dependent). In addition to the similarity with the typical three-junction flux qubit in the double-well regime, we demonstrate the difference of the four-junction circuit from its three-junction analogue, including its advantages over the latter. Moreover, the four-junction circuit in the single-well regime is also investigated. Our theory provides a tool to explore the physical properties of this four-junction superconducting circuit. PMID:27356619

  5. Four-junction superconducting circuit.

    PubMed

    Qiu, Yueyin; Xiong, Wei; He, Xiao-Ling; Li, Tie-Fu; You, J Q

    2016-06-30

    We develop a theory for the quantum circuit consisting of a superconducting loop interrupted by four Josephson junctions and pierced by a magnetic flux (either static or time-dependent). In addition to the similarity with the typical three-junction flux qubit in the double-well regime, we demonstrate the difference of the four-junction circuit from its three-junction analogue, including its advantages over the latter. Moreover, the four-junction circuit in the single-well regime is also investigated. Our theory provides a tool to explore the physical properties of this four-junction superconducting circuit.

  6. A Circuit to Demonstrate Phase Relationships in "RLC" Circuits

    ERIC Educational Resources Information Center

    Sokol, P. E.; Warren, G.; Zheng, B.; Smith, P.

    2013-01-01

    We have developed a circuit to demonstrate the phase relationships between resistive and reactive elements in series "RLC" circuits. We utilize a differential amplifier to allow the phases of the three elements and the current to be simultaneously displayed on an inexpensive four channel oscilloscope. We have included a novel circuit…

  7. Spatial and size-frequency distributions of boulders on the floor of crater Boguslawsky, the primary target of the Luna-Glob mission.

    NASA Astrophysics Data System (ADS)

    Ivanov, Mikhail; Head, James; Hiesinger, Harald; Bazilevskiy, Alexander; Hendrik Pasckert, Jan; Bauch, Karin

    Crater Boguslawsky (73S, 44E) is the primary target for the lander-oriented Russian mission Luna-Glob. The rocky surfaces represent serious threats to landers. We have conducted a survey of the NAC images seeking for the rocky sites on the floor and assessing quantitative parameters of the size-frequency distributions (SFD) of boulders. Two craters on the Boguslawsky floor show abundant boulders in their surroundings. In the vicinity of Crater 1 (73.0S, 42.0E, 405 m), we have counted 9,000 rock fragments (1-13 m) at a radial distance <670 m outside the crater rim. The mean density of boulders in this zone is 76 rocks/10,000 m2. Boulders are arranged in elongated ray-like clusters. Shallow grooves (tracks) are associated with some larger boulders; the visible depth of the tracks is 0.3-0.5 m. There are 3,200 boulders (1-8 m) around Crater 4 (72.6S 44.9E, 340 m) at a radial distance <500 m outside the crater rim; the mean density is 52 rocks/10,000 m2. The spatial distribution of boulders around Crater 4 is similar to that at Crater 1, but no tracks are associated with boulders at Crater 4. The mean density of boulders around Crater 4 is 30% less than that at Crater 1, which suggests that Crater 4 is 30-50 Ma older than Crater 1 [Basilevsky et al., 2013]. The lack of boulder tracks in the vicinity of Crater 4 implies that a layer of regolith 0.3-0.5 m thick has been reworked during this time interval. A slope of -4.37 characterizes the SFD of boulders around Crater 1, whereas the SFD of boulders around Crater 4 has a slope of -5.54. These differences in slope indicate the preferential destruction of the larger rock fragments and suggest that up to 90% of boulders in the diameter range 8-12 m are fragmented into smaller pieces during the 30-50 Ma time span.

  8. STOCK AND DISTRIBUTION OF TOTAL AND CORN-DERIVED SOIL ORGANIC CARBON IN AGGREGATE AND PRIMARY PARTICLE FRACTIONS FOR DIFFERENT LAND USE AND SOIL MANAGEMENT PRACTICES

    SciTech Connect

    Puget, P; Lal, Rattan; Izaurralde, R Cesar C.; Post, M; Owens, Lloyd

    2005-04-01

    Land use, soil management, and cropping systems affect stock, distribution, and residence time of soil organic carbon (SOC). Therefore, SOC stock and its depth distribution and association with primary and secondary particles were assessed in long-term experiments at the North Appalachian Experimental Watersheds near Coshocton, Ohio, through *13C techniques. These measurements were made for five land use and soil management treatments: (1) secondary forest, (2) meadow converted from no-till (NT) corn since 1988, (3) continuous NT corn since 1970, (4) continuous NT corn-soybean in rotation with ryegrass since 1984, and (5) conventional plow till (PT) corn since 1984. Soil samples to 70-cm depth were obtained in 2002 in all treatments. Significant differences in soil properties were observed among land use treatments for 0 to 5-cm depth. The SOC concentration (g C kg*1 of soil) in the 0 to 5-cm layer was 44.0 in forest, 24.0 in meadow, 26.1 in NT corn, 19.5 in NT corn-soybean, and 11.1 i n PT corn. The fraction of total C in corn residue converted to SOC was 11.9% for NT corn, 10.6% for NT corn-soybean, and 8.3% for PT corn. The proportion of SOC derived from corn residue was 96% for NT corn in the 0 to 5-cm layer, and it decreased gradually with depth and was 50% in PT corn. The mean SOC sequestration rate on conversion from PT to NT was 280 kg C ha*1 y*1. The SOC concentration decreased with reduction in aggregate size, and macro-aggregates contained 15 to 35% more SOC concentration than microaggregates. In comparison with forest, the magnitude of SOC depletion in the 0 to 30-cm layer was 15.5 Mg C/ha (24.0%) in meadow, 12.7 Mg C/ha (19.8%) in NT corn, 17.3 Mg C/ha (26.8%) in NT corn-soybean, and 23.3 Mg C/ha (35.1%) in PT corn. The SOC had a long turnover time when located deeper in the subsoil.

  9. Development of beam lead RF integrated circuits

    NASA Technical Reports Server (NTRS)

    Kline, A. J.; Kermode, A. W.

    1975-01-01

    This paper describes the design and development of a set of multifunction VHF/UHF integrated circuits aimed at providing a major improvement in spacecraft radio reliability through low stress operation and the processing of these circuits in beam-lead form. The methods evolved for the high frequency characterization of the devices are discussed together with the design of suitable test fixtures. Typical test results and the distribution of test parameters are presented. A unique carrier for beam-lead devices is described, and the need for such a device is discussed. The application of the carrier to device screening, burn-in and drift measurements is discussed together with the incentives for providing these capabilities. An overview of the integration of the devices into the spacecraft radio is given and candidate assembly processes are discussed. The technology impact of this approach upon future spacecraft radio systems is qualitatively examined.

  10. ELECTRONIC INTEGRATING CIRCUIT

    DOEpatents

    Englemann, R.H.

    1963-08-20

    An electronic integrating circuit using a transistor with a capacitor connected between the emitter and collector through which the capacitor discharges at a rate proportional to the input current at the base is described. Means are provided for biasing the base with an operating bias and for applying a voltage pulse to the capacitor for charging to an initial voltage. A current dividing diode is connected between the base and emitter of the transistor, and signal input terminal means are coupled to the juncture of the capacitor and emitter and to the base of the transistor. At the end of the integration period, the residual voltage on said capacitor is less by an amount proportional to the integral of the input signal. Either continuous or intermittent periods of integration are provided. (AEC)

  11. Photoconductive circuit element reflectometer

    DOEpatents

    Rauscher, C.

    1987-12-07

    A photoconductive reflectometer for characterizing semiconductor devices at millimeter wavelength frequencies where a first photoconductive circuit element (PCE) is biased by a direct current voltage source and produces short electrical pulses when excited into conductance by short first laser light pulses. The electrical pulses are electronically conditioned to improve the frequency related amplitude characteristics of the pulses which thereafter propagate along a transmission line to a device under test. Second PCEs are connected along the transmission line to sample the signals on the transmission line when excited into conductance by short second laser light pulses, spaced apart in time a determinable period from the first laser light pulses. Electronic filters connected to each of the second PCEs act as low-pass filters and remove parasitic interference from the sampled signals and output the sampled signals in the form of slowed-motion images of the signals on the transmission line. 4 figs.

  12. Photoconductive circuit element reflectometer

    DOEpatents

    Rauscher, Christen

    1990-01-01

    A photoconductive reflectometer for characterizing semiconductor devices at millimeter wavelength frequencies where a first photoconductive circuit element (PCE) is biased by a direct current voltage source and produces short electrical pulses when excited into conductance by short first laser light pulses. The electrical pulses are electronically conditioned to improve the frequency related amplitude characteristics of the pulses which thereafter propagate along a transmission line to a device under test. Second PCEs are connected along the transmission line to sample the signals on the transmission line when excited into conductance by short second laser light pulses, spaced apart in time a variable period from the first laser light pulses. Electronic filters connected to each of the second PCEs act as low-pass filters and remove parasitic interference from the sampled signals and output the sampled signals in the form of slowed-motion images of the signals on the transmission line.

  13. ELECTRONIC PULSE SCALING CIRCUITS

    DOEpatents

    Cooke-Yarborough, E.H.

    1958-11-18

    Electronic pulse scaling circults of the klnd comprlsing a serles of bi- stable elements connected ln sequence, usually in the form of a rlng so as to be cycllcally repetitive at the highest scallng factor, are described. The scaling circuit comprises a ring system of bi-stable elements each arranged on turn-off to cause, a succeeding element of the ring to be turned-on, and one being arranged on turn-off to cause a further element of the ring to be turned-on. In addition, separate means are provided for applying a turn-off pulse to all the elements simultaneously, and for resetting the elements to a starting condition at the end of each cycle.

  14. Modeling cortical circuits.

    SciTech Connect

    Rohrer, Brandon Robinson; Rothganger, Fredrick H.; Verzi, Stephen J.; Xavier, Patrick Gordon

    2010-09-01

    The neocortex is perhaps the highest region of the human brain, where audio and visual perception takes place along with many important cognitive functions. An important research goal is to describe the mechanisms implemented by the neocortex. There is an apparent regularity in the structure of the neocortex [Brodmann 1909, Mountcastle 1957] which may help simplify this task. The work reported here addresses the problem of how to describe the putative repeated units ('cortical circuits') in a manner that is easily understood and manipulated, with the long-term goal of developing a mathematical and algorithmic description of their function. The approach is to reduce each algorithm to an enhanced perceptron-like structure and describe its computation using difference equations. We organize this algorithmic processing into larger structures based on physiological observations, and implement key modeling concepts in software which runs on parallel computing hardware.

  15. VLSI circuits implementing computational models of neocortical circuits.

    PubMed

    Wijekoon, Jayawan H B; Dudek, Piotr

    2012-09-15

    This paper overviews the design and implementation of three neuromorphic integrated circuits developed for the COLAMN ("Novel Computing Architecture for Cognitive Systems based on the Laminar Microcircuitry of the Neocortex") project. The circuits are implemented in a standard 0.35 μm CMOS technology and include spiking and bursting neuron models, and synapses with short-term (facilitating/depressing) and long-term (STDP and dopamine-modulated STDP) dynamics. They enable execution of complex nonlinear models in accelerated-time, as compared with biology, and with low power consumption. The neural dynamics are implemented using analogue circuit techniques, with digital asynchronous event-based input and output. The circuits provide configurable hardware blocks that can be used to simulate a variety of neural networks. The paper presents experimental results obtained from the fabricated devices, and discusses the advantages and disadvantages of the analogue circuit approach to computational neural modelling. PMID:22342970

  16. Turkish Students' Conceptions about the Simple Electric Circuits

    ERIC Educational Resources Information Center

    Cepni, Salih; Keles, Esra

    2006-01-01

    In this study, the Turkish students' understanding level of electric circuits consisting of two bulbs and one battery was investigated by using open-ended questions. Two-hundred fifty students, whose ages range from 11 to 22, were chosen from five different groups at primary, secondary and university levels in Trabzon in Turkey. In analyzing…

  17. Researchers Find Essential Brain Circuit in Visual Development

    MedlinePlus

    ... If this circuit could be controlled in the human brain — for example, with a drug or with implants ... the nation’s leading funder of research on the brain and nervous system. The ... of Health and Human Services. NIH is the primary federal agency conducting ...

  18. CIRCUS--A digital computer program for transient analysis of electronic circuits

    NASA Technical Reports Server (NTRS)

    Moore, W. T.; Steinbert, L. L.

    1968-01-01

    Computer program simulates the time domain response of an electronic circuit to an arbitrary forcing function. CIRCUS uses a charge-control parameter model to represent each semiconductor device. Given the primary photocurrent, the transient behavior of a circuit in a radiation environment is determined.

  19. Ion implanted dielectric elastomer circuits

    NASA Astrophysics Data System (ADS)

    O'Brien, Benjamin M.; Rosset, Samuel; Anderson, Iain A.; Shea, Herbert R.

    2013-06-01

    Starfish and octopuses control their infinite degree-of-freedom arms with panache—capabilities typical of nature where the distribution of reflex-like intelligence throughout soft muscular networks greatly outperforms anything hard, heavy, and man-made. Dielectric elastomer actuators show great promise for soft artificial muscle networks. One way to make them smart is with piezo-resistive Dielectric Elastomer Switches (DES) that can be combined with artificial muscles to create arbitrary digital logic circuits. Unfortunately there are currently no reliable materials or fabrication process. Thus devices typically fail within a few thousand cycles. As a first step in the search for better materials we present a preliminary exploration of piezo-resistors made with filtered cathodic vacuum arc metal ion implantation. DES were formed on polydimethylsiloxane silicone membranes out of ion implanted gold nano-clusters. We propose that there are four distinct regimes (high dose, above percolation, on percolation, low dose) in which gold ion implanted piezo-resistors can operate and present experimental results on implanted piezo-resistors switching high voltages as well as a simple artificial muscle inverter. While gold ion implanted DES are limited by high hysteresis and low sensitivity, they already show promise for a range of applications including hysteretic oscillators and soft generators. With improvements to implanter process control the promise of artificial muscle circuitry for soft smart actuator networks could become a reality.

  20. Digital circuits using universal logic gates

    NASA Technical Reports Server (NTRS)

    Whitaker, Sterling R. (Inventor); Miles, Lowell H. (Inventor); Cameron, Eric G. (Inventor); Donohoe, Gregory W. (Inventor); Gambles, Jody W. (Inventor)

    2004-01-01

    According to the invention, a digital circuit design embodied in at least one of a structural netlist, a behavioral netlist, a hardware description language netlist, a full-custom ASIC, a semi-custom ASIC, an IP core, an integrated circuit, a hybrid of chips, one or more masks, a FPGA, and a circuit card assembly is disclosed. The digital circuit design includes first and second sub-circuits. The first sub-circuits comprise a first percentage of the digital circuit design and the second sub-circuits comprise a second percentage of the digital circuit design. Each of the second sub-circuits is substantially comprised of one or more kernel circuits. The kernel circuits are comprised of selection circuits. The second percentage is at least 5%. In various embodiments, the second percentage could be at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 95%.

  1. Compact Circuit Preprocesses Accelerometer Output

    NASA Technical Reports Server (NTRS)

    Bozeman, Richard J., Jr.

    1993-01-01

    Compact electronic circuit transfers dc power to, and preprocesses ac output of, accelerometer and associated preamplifier. Incorporated into accelerometer case during initial fabrication or retrofit onto commercial accelerometer. Made of commercial integrated circuits and other conventional components; made smaller by use of micrologic and surface-mount technology.

  2. Demonstrations with an "LCR" Circuit

    ERIC Educational Resources Information Center

    Kraftmakher, Yaakov

    2011-01-01

    The "LCR" circuit is an important topic in the course of electricity and magnetism. Papers in this field consider mainly the forced oscillations and resonance. Our aim is to show how to demonstrate the free and self-excited oscillations in an "LCR" circuit. (Contains 4 figures.)

  3. Sequential Polarity-Reversing Circuit

    NASA Technical Reports Server (NTRS)

    Labaw, Clayton C.

    1994-01-01

    Proposed circuit reverses polarity of electric power supplied to bidirectional dc motor, reversible electro-mechanical actuator, or other device operating in direction depending on polarity. Circuit reverses polarity each time power turned on, without need for additional polarity-reversing or direction signals and circuitry to process them.

  4. Dive In to Aquatic Circuits.

    ERIC Educational Resources Information Center

    Goldfarb, Joseph M.

    1995-01-01

    The article presents a method for swimming teachers and coaches to stave off workout boredom in their students by using a circuit in the pool. After explaining how to set up a training circuit, the article describes sample stations and notes important safety precautions. (SM)

  5. Pharmacokinetics and "RC" Circuit Concepts

    ERIC Educational Resources Information Center

    De Cock, Mieke; Janssen, Paul

    2013-01-01

    Most introductory physics courses include a chapter on "RC" circuits in which the differential equations for the charging and discharging of a capacitor are derived. A number of papers in this journal describe lab experiments dealing with the measurement of different parameters in such "RC" circuits. In this contribution, we…

  6. 49 CFR 236.728 - Circuit, trap.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Circuit, trap. 236.728 Section 236.728... Circuit, trap. A term applied to a circuit used where it is desirable to provide a track circuit but where it is impracticable to maintain a track circuit....

  7. 49 CFR 236.728 - Circuit, trap.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Circuit, trap. 236.728 Section 236.728... Circuit, trap. A term applied to a circuit used where it is desirable to provide a track circuit but where it is impracticable to maintain a track circuit....

  8. 49 CFR 236.728 - Circuit, trap.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Circuit, trap. 236.728 Section 236.728... Circuit, trap. A term applied to a circuit used where it is desirable to provide a track circuit but where it is impracticable to maintain a track circuit....

  9. An Electronics Course Emphasizing Circuit Design

    ERIC Educational Resources Information Center

    Bergeson, Haven E.

    1975-01-01

    Describes a one-quarter introductory electronics course in which the students use a variety of inexpensive integrated circuits to design and construct a large number of useful circuits. Presents the subject matter of the course in three parts: linear circuits, digital circuits, and more complex circuits. (GS)

  10. 49 CFR 236.728 - Circuit, trap.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Circuit, trap. 236.728 Section 236.728... Circuit, trap. A term applied to a circuit used where it is desirable to provide a track circuit but where it is impracticable to maintain a track circuit....

  11. Principles of genetic circuit design.

    PubMed

    Brophy, Jennifer A N; Voigt, Christopher A

    2014-05-01

    Cells navigate environments, communicate and build complex patterns by initiating gene expression in response to specific signals. Engineers seek to harness this capability to program cells to perform tasks or create chemicals and materials that match the complexity seen in nature. This Review describes new tools that aid the construction of genetic circuits. Circuit dynamics can be influenced by the choice of regulators and changed with expression 'tuning knobs'. We collate the failure modes encountered when assembling circuits, quantify their impact on performance and review mitigation efforts. Finally, we discuss the constraints that arise from circuits having to operate within a living cell. Collectively, better tools, well-characterized parts and a comprehensive understanding of how to compose circuits are leading to a breakthrough in the ability to program living cells for advanced applications, from living therapeutics to the atomic manufacturing of functional materials.

  12. Demultiplexer circuit for neural stimulation

    DOEpatents

    Wessendorf, Kurt O; Okandan, Murat; Pearson, Sean

    2012-10-09

    A demultiplexer circuit is disclosed which can be used with a conventional neural stimulator to extend the number of electrodes which can be activated. The demultiplexer circuit, which is formed on a semiconductor substrate containing a power supply that provides all the dc electrical power for operation of the circuit, includes digital latches that receive and store addressing information from the neural stimulator one bit at a time. This addressing information is used to program one or more 1:2.sup.N demultiplexers in the demultiplexer circuit which then route neural stimulation signals from the neural stimulator to an electrode array which is connected to the outputs of the 1:2.sup.N demultiplexer. The demultiplexer circuit allows the number of individual electrodes in the electrode array to be increased by a factor of 2.sup.N with N generally being in a range of 2-4.

  13. Genetic Dissection of Neural Circuits

    PubMed Central

    Luo, Liqun; Callaway, Edward M.; Svoboda, Karel

    2009-01-01

    Understanding the principles of information processing in neural circuits requires systematic characterization of the participating cell types and their connections, and the ability to measure and perturb their activity. Genetic approaches promise to bring experimental access to complex neural systems, including genetic stalwarts such as the fly and mouse, but also to nongenetic systems such as primates. Together with anatomical and physiological methods, cell-type-specific expression of protein markers and sensors and transducers will be critical to construct circuit diagrams and to measure the activity of genetically defined neurons. Inactivation and activation of genetically defined cell types will establish causal relationships between activity in specific groups of neurons, circuit function, and animal behavior. Genetic analysis thus promises to reveal the logic of the neural circuits in complex brains that guide behaviors. Here we review progress in the genetic analysis of neural circuits and discuss directions for future research and development. PMID:18341986

  14. Gate drive latching circuit for an auxiliary resonant commutation circuit

    NASA Technical Reports Server (NTRS)

    Delgado, Eladio Clemente (Inventor); Kheraluwala, Mustansir Hussainy (Inventor)

    1999-01-01

    A gate drive latching circuit for an auxiliary resonant commutation circuit for a power switching inverter includes a current monitor circuit providing a current signal to a pair of analog comparators to implement latching of one of a pair of auxiliary switching devices which are used to provide commutation current for commutating switching inverters in the circuit. Each of the pair of comparators feeds a latching circuit which responds to an active one of the comparators for latching the associated gate drive circuit for one of the pair of auxiliary commutating switches. An initial firing signal is applied to each of the commutating switches to gate each into conduction and the resulting current is monitored to determine current direction and therefore the one of the switches which is carrying current. The comparator provides a latching signal to the one of the auxiliary power switches which is actually conducting current and latches that particular power switch into an on state for the duration of current through the device. The latching circuit is so designed that the only time one of the auxiliary switching devices can be latched on is during the duration of an initial firing command signal.

  15. Piezo-optomechanical circuits

    NASA Astrophysics Data System (ADS)

    Coimbatore Balram, Krishna; Davanco, Marcelo; Ilic, B. Robert; Srinivasan, Kartik

    Coherent links between the optical, radio frequency (RF), and mechanical domains are critical for applications ranging from quantum state transfer between the RF and optical domains to signal processing in the acoustic domain for microwave photonics. We develop such a piezo optomechanical circuit platform in GaAs, in which localized and interacting 1550 nm photons and 2.4 GHz phonons are combined with photonic and phononic waveguides. GaAs allows us to exploit the photoelastic effect to engineer cavities with strong optomechanical coupling (g0/2 π ~ 1.1 MHz) and the piezoelectric effect to couple RF fields to mechanical motion through surface acoustic waves, which are routed on-chip using phononic crystal waveguides. This platform enables optical readout of electrically-injected mechanical states with an average coherent intracavity phonon number as small as ~0.05 and the ability to drive mechanical motion with equal facility through either the optical or electrical channel. This is used to demonstrate a novel acoustic wave interference effect in which optically-driven motion is completely cancelled by electrically-driven motion, and vice versa. As an application of this, we present time-domain measurements of optically-controlled acoustic pulse propagation. Secondary Affiliation is Maryland Nanocenter, University of Maryland, College Park, MD.

  16. Visual Experience Modulates Spatio-Temporal Dynamics of Circuit Activation

    PubMed Central

    Wang, Lang; Fontanini, Alfredo; Maffei, Arianna

    2011-01-01

    Persistent reduction in sensory drive in early development results in multiple plastic changes of different cortical synapses. How these experience-dependent modifications affect the spatio-temporal dynamics of signal propagation in neocortical circuits is poorly understood. Here we demonstrate that brief visual deprivation significantly affects the propagation of electrical signals in the primary visual cortex. The spatio-temporal spread of circuit activation upon direct stimulation of its input layer (Layer 4) is reduced, as is the activation of L2/3 – the main recipient of the output from L4. Our data suggest that the decrease in spatio-temporal activation of L2/3 depends on reduced L4 output, and is not intrinsically generated within L2/3. The data shown here suggest that changes in the synaptic components of the visual cortical circuit result not only in alteration of local integration of excitatory and inhibitory inputs, but also in a significant decrease in overall circuit activation. Furthermore, our data indicate a differential effect of visual deprivation on L4 and L2/3, suggesting that while feedforward activation of L2/3 is reduced, its activation by long range, within layer inputs is unaltered. Thus, brief visual deprivation induces experience-dependent circuit re-organization by modulating not only circuit excitability, but also the spatio-temporal patterns of cortical activation within and between layers. PMID:21743804

  17. Low distortion automatic phase control circuit

    NASA Technical Reports Server (NTRS)

    Hauge, G.; Pederson, C. W.

    1972-01-01

    Circuit for generation and demodulation of quadrature double side band signals in frequency division multiplexing system is described. Circuit is designed to produce low distortion automatic phase control. Illustration of circuit and components is included.

  18. Gyrator circuit using field effect transistors

    NASA Technical Reports Server (NTRS)

    Hochmair, E. S.

    1973-01-01

    Gyrator circuit is especially useful in integrated circuits for such purposes as simulating inductors with capacitors. Circuit is adaptable to semifloating and full floating configurations. It has excellent response, low power consumption, and high energy storage capacity.

  19. 49 CFR 236.731 - Controller, circuit.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Controller, circuit. A device for opening and closing electric circuits. ... 49 Transportation 4 2013-10-01 2013-10-01 false Controller, circuit. 236.731 Section 236.731 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD...

  20. Performance analysis of electrical circuits /PANE/

    NASA Technical Reports Server (NTRS)

    Johnson, K. L.; Steinberg, L. L.

    1968-01-01

    Automated statistical and worst case computer program has been designed to perform dc and ac steady circuit analyses. The program determines the worst case circuit performance by solving circuit equations.

  1. 30 CFR 75.800 - High-voltage circuits; circuit breakers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false High-voltage circuits; circuit breakers. 75.800... § 75.800 High-voltage circuits; circuit breakers. High-voltage circuits entering the underground area of any coal mine shall be protected by suitable circuit breakers of adequate interrupting...

  2. 30 CFR 75.800 - High-voltage circuits; circuit breakers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false High-voltage circuits; circuit breakers. 75.800... § 75.800 High-voltage circuits; circuit breakers. High-voltage circuits entering the underground area of any coal mine shall be protected by suitable circuit breakers of adequate interrupting...

  3. 30 CFR 75.800 - High-voltage circuits; circuit breakers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false High-voltage circuits; circuit breakers. 75.800... § 75.800 High-voltage circuits; circuit breakers. High-voltage circuits entering the underground area of any coal mine shall be protected by suitable circuit breakers of adequate interrupting...

  4. Variational integrators for electric circuits

    SciTech Connect

    Ober-Blöbaum, Sina; Tao, Molei; Cheng, Mulin; Owhadi, Houman; Marsden, Jerrold E.

    2013-06-01

    In this contribution, we develop a variational integrator for the simulation of (stochastic and multiscale) electric circuits. When considering the dynamics of an electric circuit, one is faced with three special situations: 1. The system involves external (control) forcing through external (controlled) voltage sources and resistors. 2. The system is constrained via the Kirchhoff current (KCL) and voltage laws (KVL). 3. The Lagrangian is degenerate. Based on a geometric setting, an appropriate variational formulation is presented to model the circuit from which the equations of motion are derived. A time-discrete variational formulation provides an iteration scheme for the simulation of the electric circuit. Dependent on the discretization, the intrinsic degeneracy of the system can be canceled for the discrete variational scheme. In this way, a variational integrator is constructed that gains several advantages compared to standard integration tools for circuits; in particular, a comparison to BDF methods (which are usually the method of choice for the simulation of electric circuits) shows that even for simple LCR circuits, a better energy behavior and frequency spectrum preservation can be observed using the developed variational integrator.

  5. Global optimization of digital circuits

    NASA Astrophysics Data System (ADS)

    Flandera, Richard

    1991-12-01

    This thesis was divided into two tasks. The first task involved developing a parser which could translate a behavioral specification in Very High-Speed Integrated Circuits (VHSIC) Hardware Description Language (VHDL) into the format used by an existing digital circuit optimization tool, Boolean Reasoning In Scheme (BORIS). Since this tool is written in Scheme, a dialect of Lisp, the parser was also written in Scheme. The parser was implemented is Artez's modification of Earley's Algorithm. Additionally, a VHDL tokenizer was implemented in Scheme and a portion of the VHDL grammar was converted into the format which the parser uses. The second task was the incorporation of intermediate functions into BORIS. The existing BORIS contains a recursive optimization system that optimizes digital circuits by using circuit outputs as inputs into other circuits. Intermediate functions provide a greater selection of functions to be used as circuits inputs. Using both intermediate functions and output functions, the costs of the circuits in the test set were reduced by 43 percent. This is a 10 percent reduction when compared to the existing recursive optimization system. Incorporating intermediate functions into BORIS required the development of an intermediate-function generator and a set of control methods to keep the computation time from increasing exponentially.

  6. The rod circuit in the rabbit retina.

    PubMed

    Vaney, D I; Young, H M; Gynther, I C

    1991-01-01

    Mammalian retinae have a well-defined neuronal pathway that serves rod vision. In rabbit retina, the different populations of interneurons in the rod pathway can be selectively labeled, either separately or in combination. The rod bipolar cells show protein kinase C immunoreactivity; the rod (AII) amacrine cells can be distinguished in nuclear-yellow labeled retina; the rod reciprocal (S1 & S2) amacrine cells accumulate serotonin; and the dopaminergic amacrine cells show tyrosine-hydroxylase immunoreactivity. Furthermore, intracellular dye injection of the microscopically identified interneurons enables whole-population and single-cell studies to be combined in the same tissue. Using this approach, we have been able to analyze systematically the neuronal architecture of the rod circuit across the rabbit retina and compare its organization with that of the rod circuit in central cat retina. In rabbit retina, the rod interneurons are not organized in a uniform neuronal module that is simply scaled up from central to peripheral retina. Moreover, peripheral fields in superior and inferior retina that have equivalent densities of each neuronal type show markedly different rod bipolar to AII amacrine convergence ratios, with the result that many more rod photoreceptors converge on an AII amacrine cell in superior retina. In rabbit retina, much of the convergence in the rod circuit occurs in the outer retina whereas, in central cat retina, it is more evenly distributed between the inner and outer retina.

  7. Modeling and Verification of Distributed Generation and Voltage Regulation Equipment for Unbalanced Distribution Power Systems; Annual Subcontract Report, June 2007

    SciTech Connect

    Davis, M. W.; Broadwater, R.; Hambrick, J.

    2007-07-01

    This report summarizes the development of models for distributed generation and distribution circuit voltage regulation equipment for unbalanced power systems and their verification through actual field measurements.

  8. Integrated circuits, and design and manufacture thereof

    DOEpatents

    Auracher, Stefan; Pribbernow, Claus; Hils, Andreas

    2006-04-18

    A representation of a macro for an integrated circuit layout. The representation may define sub-circuit cells of a module. The module may have a predefined functionality. The sub-circuit cells may include at least one reusable circuit cell. The reusable circuit cell may be configured such that when the predefined functionality of the module is not used, the reusable circuit cell is available for re-use.

  9. Framed 4-graphs: Euler tours, Gauss circuits and rotating circuits

    SciTech Connect

    Il'yutko, Denis P

    2011-09-30

    We consider connected finite 4-valent graphs with the structure of opposite edges at each vertex (framed 4-graphs). For any of such graphs there exist Euler tours, in travelling along which at each vertex we turn from an edge to a nonopposite one (rotating circuits); and at the same time, it is not true that for any such graph there exists an Euler tour passing from an edge to the opposite one at each vertex (a Gauss circuit). The main result of the work is an explicit formula connecting the adjacency matrices of the Gauss circuit and an arbitrary Euler tour. This formula immediately gives us a criterion for the existence of a Gauss circuit on a given framed 4-graph. It turns out that the results are also valid for all symmetric matrices (not just for matrices realisable by a chord diagram). Bibliography: 24 titles.

  10. Counterpulse railgun energy recovery circuit

    DOEpatents

    Honig, E.M.

    1984-09-28

    The invention presented relates to a high-power pulsing circuit and more particularly to a repetitive pulse inductive energy storage and transfer circuit for an electromagnetic launcher. In an electromagnetic launcher such as a railgun for propelling a projectile at high velocity, a counterpulse energy recovery circuit is employed to transfer stored inductive energy from a source inductor to the railgun inductance to propel the projectile down the railgun. Switching circuitry and an energy transfer capacitor are used to switch the energy back to the source inductor in readiness for a repetitive projectile propelling cycle.

  11. Overpulse railgun energy recovery circuit

    DOEpatents

    Honig, E.M.

    1984-09-28

    The invention presented relates to a high-power pulsing circuit and more particularly to a repetitive pulse inductive energy storage and transfer circuit for an electromagnetic launcher. In an electromagnetic launcher such as a railgun for propelling a projectile at high velocity, an overpulse energy recovery circuit is employed to transfer stored inductive energy from a source inductor to the railgun inductance to propel the projectile down the railgun. Switching circuitry and an energy transfer capacitor are used to switch the energy back to the source inductor in readiness for a repetitive projectile propelling cycle.

  12. Synchrony, connectivity, and functional similarity in auditory midbrain local circuits.

    PubMed

    Atencio, Craig A; Shen, Victor; Schreiner, Christoph E

    2016-10-29

    The central nucleus of the inferior colliculus (ICC) contains a laminar structure that functions as an organizing substrate of ascending inputs and local processing. While topographic distributions of ICC response parameters within and across laminae have been reported, the functional micro-organization of the ICC is less well understood. For pairs of neighboring ICC neurons, we examined the nature of functional connectivity and receptive field preferences to gain a better understanding of the structure and function of local circuits. By recording from pairs of adjacent neurons and presenting pure-tone and dynamic broad-band stimulation, we estimated functional connectivity and local differences in frequency response areas (FRAs), spectrotemporal receptive fields (STRFs), nonlinear input/output functions, and single-spike information. From the cross-covariance functions we identified putative unidirectional as well as bidirectional excitatory/inhibitory interactions. STRFs of neighboring neurons strongly conserve best frequency, and moderately agree in STRF similarity, bandwidth, temporal response type, best modulation frequency, nonlinearity structure, and degree of information processing. Excitatory connectivity was stronger and temporally more precise than for inhibitory connections. Neither connection strength nor degree of synchrony correlated with receptive field parameters. The functional similarity of local pairs of ICC neurons was substantially less than for local pairs in the granular layers of primary auditory cortex (AI). These results imply that while the ICC is an obligatory nexus of ascending information, local neurons are comparatively weakly connected and exhibit considerable receptive field variability, potentially reflecting the heterogeneity of converging inputs to ICC functional zones.

  13. Habenula Circuit Development: Past, Present, and Future

    PubMed Central

    Beretta, Carlo A.; Dross, Nicolas; Guiterrez-Triana, Jose A.; Ryu, Soojin; Carl, Matthias

    2012-01-01

    The habenular neural circuit is attracting increasing attention from researchers in fields as diverse as neuroscience, medicine, behavior, development, and evolution. Recent studies have revealed that this part of the limbic system in the dorsal diencephalon is involved in reward, addiction, and other behaviors and its impairment is associated with various neurological conditions and diseases. Since the initial description of the dorsal diencephalic conduction system (DDC) with the habenulae in its center at the end of the nineteenth century, increasingly sophisticated techniques have resolved much of its anatomy and have shown that these pathways relay information from different parts of the forebrain to the tegmentum, midbrain, and hindbrain. The first part of this review gives a brief historical overview on how the improving experimental approaches have allowed the stepwise uncovering much of the architecture of the habenula circuit as we know it today. Our brain distributes tasks differentially between left and right and it has become a paradigm that this functional lateralization is a universal feature of vertebrates. Moreover, task dependent differential brain activities have been linked to anatomical differences across the left–right axis in humans. A good way to further explore this fundamental issue will be to study the functional consequences of subtle changes in neural network formation, which requires that we fully understand DDC system development. As the habenular circuit is evolutionarily highly conserved, researchers have the option to perform such difficult experiments in more experimentally amenable vertebrate systems. Indeed, research in the last decade has shown that the zebrafish is well suited for the study of DDC system development and the phenomenon of functional lateralization. We will critically discuss the advantages of the zebrafish model, available techniques, and others that are needed to fully understand habenular circuit

  14. An electronic circuit that detects left ventricular ejection events by processing the arterial pressure waveform

    NASA Technical Reports Server (NTRS)

    Gebben, V. D.; Webb, J. A., Jr.

    1972-01-01

    An electronic circuit for processing arterial blood pressure waveform signals is described. The circuit detects blood pressure as the heart pumps blood through the aortic valve and the pressure distribution caused by aortic valve closure. From these measurements, timing signals for use in measuring the left ventricular ejection time is determined, and signals are provided for computer monitoring of the cardiovascular system. Illustrations are given of the circuit and pressure waveforms.

  15. Principles of Genetic Circuit Design

    PubMed Central

    Brophy, Jennifer A.N.; Voigt, Christopher A.

    2014-01-01

    Cells are able to navigate environments, communicate, and build complex patterns by initiating gene expression in response to specific signals. Engineers need to harness this capability to program cells to perform tasks or build chemicals and materials that match the complexity seen in nature. This review describes new tools that aid the construction of genetic circuits. We show how circuit dynamics can be influenced by the choice of regulators and changed with expression “tuning knobs.” We collate the failure modes encountered when assembling circuits, quantify their impact on performance, and review mitigation efforts. Finally, we discuss the constraints that arise from operating within a living cell. Collectively, better tools, well-characterized parts, and a comprehensive understanding of how to compose circuits are leading to a breakthrough in the ability to program living cells for advanced applications, from living therapeutics to the atomic manufacturing of functional materials. PMID:24781324

  16. Focal plane infrared readout circuit

    NASA Technical Reports Server (NTRS)

    Pain, Bedabrata (Inventor)

    2002-01-01

    An infrared imager, such as a spectrometer, includes multiple infrared photodetectors and readout circuits for reading out signals from the photodetectors. Each readout circuit includes a buffered direct injection input circuit including a differential amplifier with active feedback provided through an injection transistor. The differential amplifier includes a pair of input transistors, a pair of cascode transistors and a current mirror load. Photocurrent from a photodetector can be injected onto an integration capacitor in the readout circuit with high injection efficiency at high speed. A high speed, low noise, wide dynamic range linear infrared multiplexer array for reading out infrared detectors with large capacitances can be achieved even when short exposure times are used. The effect of image lag can be reduced.

  17. Student Conceptions of Simple Circuits.

    ERIC Educational Resources Information Center

    Fredette, Norman; Lochhead, John

    1980-01-01

    Investigates some conceptual difficulties which college students have with regard to simple direct current circuits. The clinical interview technique was used with 57 students in a freshman level engineering course. (HM)

  18. CADAT integrated circuit mask analysis

    NASA Technical Reports Server (NTRS)

    1981-01-01

    CADAT System Mask Analysis Program (MAPS2) is automated software tool for analyzing integrated-circuit mask design. Included in MAPS2 functions are artwork verification, device identification, nodal analysis, capacitance calculation, and logic equation generation.

  19. Optoelectronic integrated circuits

    NASA Astrophysics Data System (ADS)

    Forrest, Stephen R.

    1987-11-01

    The technology development requirements of several generic photonic systems for advanced optoelectronic ICs are currently being met by the fabrication of highly functional integrated transmitters, receivers, modulators, and arrays of such devices. Attention is presently given to illustrative examples of each of these, as well as of other 'archetypal' ICs. It is noted that the materials-growth techniques employed in optoelectronic IC structures constitute the foundation of their development hierarchy; the primary pacer of development progress is therefore the rapidity of advancements in epitaxial materials-growth technology.

  20. Reverse engineering of integrated circuits

    DOEpatents

    Chisholm, Gregory H.; Eckmann, Steven T.; Lain, Christopher M.; Veroff, Robert L.

    2003-01-01

    Software and a method therein to analyze circuits. The software comprises several tools, each of which perform particular functions in the Reverse Engineering process. The analyst, through a standard interface, directs each tool to the portion of the task to which it is most well suited, rendering previously intractable problems solvable. The tools are generally used iteratively to produce a successively more abstract picture of a circuit, about which incomplete a priori knowledge exists.

  1. Distribute What?

    ERIC Educational Resources Information Center

    Brown, Wayne A.

    1989-01-01

    Distributed Data Processing, linking a central processing unit to remote computer sites, allows end users more control over their own destiny. Schools have distributed hardware and software but not talent. The primary goal of these staff experts should be to educate users as fully as they can. (MLW)

  2. Receiver Gain Modulation Circuit

    NASA Technical Reports Server (NTRS)

    Jones, Hollis; Racette, Paul; Walker, David; Gu, Dazhen

    2011-01-01

    A receiver gain modulation circuit (RGMC) was developed that modulates the power gain of the output of a radiometer receiver with a test signal. As the radiometer receiver switches between calibration noise references, the test signal is mixed with the calibrated noise and thus produces an ensemble set of measurements from which ensemble statistical analysis can be used to extract statistical information about the test signal. The RGMC is an enabling technology of the ensemble detector. As a key component for achieving ensemble detection and analysis, the RGMC has broad aeronautical and space applications. The RGMC can be used to test and develop new calibration algorithms, for example, to detect gain anomalies, and/or correct for slow drifts that affect climate-quality measurements over an accelerated time scale. A generalized approach to analyzing radiometer system designs yields a mathematical treatment of noise reference measurements in calibration algorithms. By treating the measurements from the different noise references as ensemble samples of the receiver state, i.e. receiver gain, a quantitative description of the non-stationary properties of the underlying receiver fluctuations can be derived. Excellent agreement has been obtained between model calculations and radiometric measurements. The mathematical formulation is equivalent to modulating the gain of a stable receiver with an externally generated signal and is the basis for ensemble detection and analysis (EDA). The concept of generating ensemble data sets using an ensemble detector is similar to the ensemble data sets generated as part of ensemble empirical mode decomposition (EEMD) with exception of a key distinguishing factor. EEMD adds noise to the signal under study whereas EDA mixes the signal with calibrated noise. It is mixing with calibrated noise that permits the measurement of temporal-functional variability of uncertainty in the underlying process. The RGMC permits the evaluation of EDA by

  3. 30 CFR 75.800-2 - Approved circuit schemes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Underground High-Voltage Distribution... undervoltage protection if the relay coils are designed to trip the circuit breaker when line voltage decreases to 40 percent to 60 percent of the nominal line voltage; (b) Ground trip relays on...

  4. 30 CFR 77.802 - Protection of high-voltage circuits; neutral grounding resistors; disconnecting devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection of high-voltage circuits; neutral... AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.802 Protection of high-voltage circuits; neutral grounding resistors; disconnecting devices. High-voltage...

  5. 30 CFR 77.803-1 - Fail safe ground check circuits; maximum voltage.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.803-1 Fail safe ground check circuits; maximum voltage. The maximum voltage used for ground check circuits under § 77.803 shall not... voltage. 77.803-1 Section 77.803-1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT...

  6. 30 CFR 77.803-1 - Fail safe ground check circuits; maximum voltage.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.803-1 Fail safe ground check circuits; maximum voltage. The maximum voltage used for ground check circuits under § 77.803 shall not... voltage. 77.803-1 Section 77.803-1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT...

  7. 30 CFR 77.803-1 - Fail safe ground check circuits; maximum voltage.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.803-1 Fail safe ground check circuits; maximum voltage. The maximum voltage used for ground check circuits under § 77.803 shall not... voltage. 77.803-1 Section 77.803-1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT...

  8. 30 CFR 77.803-1 - Fail safe ground check circuits; maximum voltage.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.803-1 Fail safe ground check circuits; maximum voltage. The maximum voltage used for ground check circuits under § 77.803 shall not... voltage. 77.803-1 Section 77.803-1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT...

  9. Multi-Layer E-Textile Circuits

    NASA Technical Reports Server (NTRS)

    Dunne, Lucy E.; Bibeau, Kaila; Mulligan, Lucie; Frith, Ashton; Simon, Cory

    2012-01-01

    Stitched e-textile circuits facilitate wearable, flexible, comfortable wearable technology. However, while stitched methods of e-textile circuits are common, multi-layer circuit creation remains a challenge. Here, we present methods of stitched multi-layer circuit creation using accessible tools and techniques.

  10. Bypassing An Open-Circuit Power Cell

    NASA Technical Reports Server (NTRS)

    Wannemacher, Harry E.

    1994-01-01

    Collection of bypass circuits enables battery consisting series string of cells to continue to function when one of its cells fails in open-circuit (high-resistance) condition. Basic idea simply to shunt current around defective cell to prevent open circuit from turning off battery altogether. Bypass circuits dissipate little power and are nearly immune to false activation.

  11. Tunable circuit for tunable capacitor devices

    DOEpatents

    Rivkina, Tatiana; Ginley, David S.

    2006-09-19

    A tunable circuit (10) for a capacitively tunable capacitor device (12) is provided. The tunable circuit (10) comprises a tunable circuit element (14) and a non-tunable dielectric element (16) coupled to the tunable circuit element (16). A tunable capacitor device (12) and a method for increasing the figure of merit in a tunable capacitor device (12) are also provided.

  12. 46 CFR 169.670 - Circuit breakers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Circuit breakers. 169.670 Section 169.670 Shipping COAST... Gross Tons § 169.670 Circuit breakers. Each circuit breaker must be of the manually reset type designed for— (a) Inverse time delay; (b) Instantaneous short circuit protection; and (c) Repeated opening...

  13. 30 CFR 56.6403 - Branch circuits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Branch circuits. 56.6403 Section 56.6403... Blasting § 56.6403 Branch circuits. (a) If electric blasting includes the use of branch circuits, each branch shall be equipped with a safety switch or equivalent method to isolate the circuits to be used....

  14. 30 CFR 56.6403 - Branch circuits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Branch circuits. 56.6403 Section 56.6403... Blasting § 56.6403 Branch circuits. (a) If electric blasting includes the use of branch circuits, each branch shall be equipped with a safety switch or equivalent method to isolate the circuits to be used....

  15. 46 CFR 169.670 - Circuit breakers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Circuit breakers. 169.670 Section 169.670 Shipping COAST... Gross Tons § 169.670 Circuit breakers. Each circuit breaker must be of the manually reset type designed for— (a) Inverse time delay; (b) Instantaneous short circuit protection; and (c) Repeated opening...

  16. 30 CFR 56.6403 - Branch circuits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Branch circuits. 56.6403 Section 56.6403... Blasting § 56.6403 Branch circuits. (a) If electric blasting includes the use of branch circuits, each branch shall be equipped with a safety switch or equivalent method to isolate the circuits to be used....

  17. 46 CFR 169.670 - Circuit breakers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Circuit breakers. 169.670 Section 169.670 Shipping COAST... Gross Tons § 169.670 Circuit breakers. Each circuit breaker must be of the manually reset type designed for— (a) Inverse time delay; (b) Instantaneous short circuit protection; and (c) Repeated opening...

  18. Difference-Equation/Flow-Graph Circuit Analysis

    NASA Technical Reports Server (NTRS)

    Mcvey, I. M.

    1988-01-01

    Numerical technique enables rapid, approximate analyses of electronic circuits containing linear and nonlinear elements. Practiced in variety of computer languages on large and small computers; for circuits simple enough, programmable hand calculators used. Although some combinations of circuit elements make numerical solutions diverge, enables quick identification of divergence and correction of circuit models to make solutions converge.

  19. 46 CFR 169.670 - Circuit breakers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Circuit breakers. 169.670 Section 169.670 Shipping COAST... Gross Tons § 169.670 Circuit breakers. Each circuit breaker must be of the manually reset type designed for— (a) Inverse time delay; (b) Instantaneous short circuit protection; and (c) Repeated opening...

  20. 30 CFR 56.6403 - Branch circuits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Branch circuits. 56.6403 Section 56.6403... Blasting § 56.6403 Branch circuits. (a) If electric blasting includes the use of branch circuits, each branch shall be equipped with a safety switch or equivalent method to isolate the circuits to be used....

  1. Grounded coplanar waveguide defected ground structure enabled mulitlayered passive circuits

    NASA Astrophysics Data System (ADS)

    Schlieter, Daniel Benjamin

    Passive circuits are essential to microwave and millimeter-wave (mm-wave) frequency design, especially as new commercial applications emerge for complementary metal-oxide semiconductor (CMOS) integrated circuits. However, it is challenging to design distributed passive circuits for CMOS due to the substrate loss and thin dielectric layers of the back-end-of-line (BEOL). Furthermore, distributed passive circuits need to be adapted for compactness and integration while overcoming these challenges and maintaining high performance. Grounded coplanar waveguide defected ground structures meet this need for compact and integrable passive circuits by utilizing the top and bottom ground planes of the transmission line to implement circuit elements. Defected ground structures (DGS) are distributed elements realized by etching specific patterns into the ground planes of transmission lines. These structures can be used in conjunction with the center conductor of planar transmission lines to reduce circuit size and/or improve performance. By implementing DGS in grounded coplanar waveguide (GCPW) multiple resonances and higher impedances can be achieved. The resonant-based GCPW DGS are more compact than their microstrip and CPW counterparts and fit well into the vertical technology of back-end-of-line CMOS. This research demonstrates up to 80% size reduction at 5.8GHz by realizing spiral-shaped DGS in GCPW and applying the resulting GCPW DGS unit cell to a dual-behavior band-pass filter. The filter has been scaled to 60GHz and realized in a 130nm CMOS process by using floating metal strips to reduce the impact of the lossy silicon substrate. The impedance-based GCPW DGS, called EG-GCPW, have up to a 20:1 impedance ratio on Rogers RT/DuroidRTM 5880 and an impedance ratio of 15:1 on a benzocyclobutene post-CMOS process. These high impedance ratios increased the power division ratio of an unequal Wilkinson power divider to 7:1 and reduced the size of a stepped impedance low

  2. Laminar circuit organization and response modulation in mouse visual cortex

    PubMed Central

    Olivas, Nicholas D.; Quintanar-Zilinskas, Victor; Nenadic, Zoran; Xu, Xiangmin

    2012-01-01

    The mouse has become an increasingly important animal model for visual system studies, but few studies have investigated local functional circuit organization of mouse visual cortex. Here we used our newly developed mapping technique combining laser scanning photostimulation (LSPS) with fast voltage-sensitive dye (VSD) imaging to examine the spatial organization and temporal dynamics of laminar circuit responses in living slice preparations of mouse primary visual cortex (V1). During experiments, LSPS using caged glutamate provided spatially restricted neuronal activation in a specific cortical layer, and evoked responses from the stimulated layer to its functionally connected regions were detected by VSD imaging. In this study, we first provided a detailed analysis of spatiotemporal activation patterns at specific V1 laminar locations and measured local circuit connectivity. Then we examined the role of cortical inhibition in the propagation of evoked cortical responses by comparing circuit activity patterns in control and in the presence of GABAa receptor antagonists. We found that GABAergic inhibition was critical in restricting layer-specific excitatory activity spread and maintaining topographical projections. In addition, we investigated how AMPA and NMDA receptors influenced cortical responses and found that blocking AMPA receptors abolished interlaminar functional projections, and the NMDA receptor activity was important in controlling visual cortical circuit excitability and modulating activity propagation. The NMDA receptor antagonist reduced neuronal population activity in time-dependent and laminar-specific manners. Finally, we used the quantitative information derived from the mapping experiments and presented computational modeling analysis of V1 circuit organization. Taken together, the present study has provided important new information about mouse V1 circuit organization and response modulation. PMID:23060751

  3. Laminar circuit organization and response modulation in mouse visual cortex.

    PubMed

    Olivas, Nicholas D; Quintanar-Zilinskas, Victor; Nenadic, Zoran; Xu, Xiangmin

    2012-01-01

    The mouse has become an increasingly important animal model for visual system studies, but few studies have investigated local functional circuit organization of mouse visual cortex. Here we used our newly developed mapping technique combining laser scanning photostimulation (LSPS) with fast voltage-sensitive dye (VSD) imaging to examine the spatial organization and temporal dynamics of laminar circuit responses in living slice preparations of mouse primary visual cortex (V1). During experiments, LSPS using caged glutamate provided spatially restricted neuronal activation in a specific cortical layer, and evoked responses from the stimulated layer to its functionally connected regions were detected by VSD imaging. In this study, we first provided a detailed analysis of spatiotemporal activation patterns at specific V1 laminar locations and measured local circuit connectivity. Then we examined the role of cortical inhibition in the propagation of evoked cortical responses by comparing circuit activity patterns in control and in the presence of GABAa receptor antagonists. We found that GABAergic inhibition was critical in restricting layer-specific excitatory activity spread and maintaining topographical projections. In addition, we investigated how AMPA and NMDA receptors influenced cortical responses and found that blocking AMPA receptors abolished interlaminar functional projections, and the NMDA receptor activity was important in controlling visual cortical circuit excitability and modulating activity propagation. The NMDA receptor antagonist reduced neuronal population activity in time-dependent and laminar-specific manners. Finally, we used the quantitative information derived from the mapping experiments and presented computational modeling analysis of V1 circuit organization. Taken together, the present study has provided important new information about mouse V1 circuit organization and response modulation.

  4. Architecture and algorithm of a circuit simulator

    NASA Astrophysics Data System (ADS)

    Marranghello, Norian; Damiani, Furio

    1990-11-01

    Software-based circuit simulators had a ten-fold speed improvement in the last 15 years. Despite this they are not fast enough to cost- effectively deal with current VLSI circuits. In this paper we describe the current status of the ABACUS circuit simulator project, which takes advantage of both a dedicated hardware to speed up circuit simulation and a new methodology, where each parallel processor behaves like a circuit element.

  5. MEMS high-Q tunable capacitor for reconfigurable microwave circuits

    NASA Astrophysics Data System (ADS)

    Nordquist, Christopher D.; Muyshondt, Arnoldo; Pack, Michael V.; Finnegan, Patrick S.; Dyck, Christopher W.; Reines, Isak C.; Kraus, Garth M.; Sloan, George R.; Sullivan, Charles T.

    2003-01-01

    Future microwave networks require miniature high-performance tunable elements such as switches, inductors, and capacitors. We report a micro-machined high-performance tunable capacitor suitable for reconfigurable monolithic microwave integrated circuits (MMICs). The capacitor is fabricated on a GaAs substrate using low-temperature processing, making it suitable for post-process integration with MMICs, radio frequency integrated circuits (RFICs) and other miniaturized circuits. Additionally, the insulating substrate and high-conductivity metal provide low-loss operation at frequencies over 20 GHz. The device demonstrates a capacitance of 150 fF at 0 V bias, pull-in at about 15 V to 18 V, and further linear tuning from 290 fF to 350 fF over a voltage range of 7 V to 30 V. Also, the device demonstrates self-resonance frequencies over 50 GHz, and Q"s over 100 at 10 GHz. To enable integration into circuits, a simple equivalent circuit model of the device has been developed, demonstrating a good match to the measured data through 25 GHz. Initial testing to 1 billion cycles indicates that metal fatigue is the primary limitation to reliability and reproducibility, and that dielectric charging does not have a significant impact on the device. This device is promising for high-performance tunable filters, phase shifters, and other reconfigurable networks at frequencies through K-band.

  6. Sleep protects excitatory cortical circuits against oxidative damage.

    PubMed

    Schulze, Georg

    2004-01-01

    Activity in excitatory cortical pathways increases the oxidative metabolism of the brain and the risk of oxidative damage. Oxyradicals formed during periods of activity are mopped up by neural pools of nuclear factor kappa-B resulting in their activation and translocation to cell nuclei. During waking hours, glucocorticoids inhibit transactivation by nuclear factor kappa-B, increase central norepinephrine release, and elevate expression of prostaglandin D2. The build-up of nuclear factor kappa-B and prostaglandin D2 produces sleep pressures leading to sleep onset, normally gated by circadian melatonin release. During slow wave sleep nuclear factor kappa-B induces transcription of synaptogenic and antioxidant products and synaptic remodeling follows. Synaptically remodeled neural circuits have modified conductivity patterns and timescales and need to be resynchronized with existing unmodified neural circuits. The resynchronization process, mediated by theta rhythm, occurs during rapid eye movement sleep and is orchestrated from pontine centers. Resynchronization of remodeled neural circuits produces dreams. The waking state results upon successful resynchronization. Rapid eye movement sleep deprivation results in a lack of resynchronization and leads to cognitive inefficiencies. The model presented here proposes that the primary purpose of sleep is to protect cortical circuits against oxidative damage by reducing cortical activity and by remodeling and resynchronizing cortical circuits during this period of reduced activity to sustain new patterns of activation more effectively.

  7. Conceptual studies for a mercury target circuit

    SciTech Connect

    Sigg, B.

    1996-06-01

    For the now favored target design of the European Spallation Source project, i.e. the version using mercury as target material, a basic concept of the primary system has been worked out. It does not include a detailed design of the various components of the target circuit, but tries to outline a feasible solution for the system. Besides the removal of the thermal power of about 3MW produced in the target by the proton beam, the primary system has to satisfy a number of other requirements related to processing, safety, and operation. The basic proposal uses an electromagnetic pump and a mercury-water intermediate heat excanger, but other alternatives are also being discussed. Basic safety requirements, i.e. protection against radiation and toxic mercury vapours, are satisfied by a design using an air-tight primary system containment, double-walled tubes in the intermediate heat exchanger, a fail-safe system for decay heat removal, and a remote handling facility for the active part of the system. Much engineering work has still to be done, because many details of the design of the mercury and gas processing systems remain to be clarified, the thermal-hydraulic components need further optimisation, the system for control and instrumentation is only known in outline and a through safety analysis will be required.

  8. Digital first order hold circuit

    NASA Technical Reports Server (NTRS)

    Chan, Fred N. (Inventor); Wensley, Gerald J. (Inventor)

    1989-01-01

    There is provided a digitally controlled first order hold circuit and waveform synthesizer for digitally controlling the representation of a function over an approximation interval. In accordance with the operation of the invention, the first order hold circuit and waveform generator receives a digital data input signal which contains initial condition data, up/down data, and slope data for the approximation interval. The initial condition data is loaded into an up/down counter which is incremented using counting data at a rate depending on the value of the slope data and in a direction depending on the value of the up-down data. In order to minimize delays arising from data acquistion, two frequency synthesizer circuits are provided such that one frequency synthesizer provides counting data while the other frequency synthesizer receives slope data. During alternating intervals, the other frequency synthesizer circuit provides counting data while the other circuit receives slope data. In addition, long length data input signals covering a plurality of approximation intervals are provided to reduce the demands on a main system central processing unit.

  9. Neurotrophins and spinal circuit function

    PubMed Central

    Boyce, Vanessa S.; Mendell, Lorne M.

    2014-01-01

    Work early in the last century emphasized the stereotyped activity of spinal circuits based on studies of reflexes. However, the last several decades have focused on the plasticity of these spinal circuits. These considerations began with studies of the effects of monoamines on descending and reflex circuits. In recent years new classes of compounds called growth factors that are found in peripheral nerves and the spinal cord have been shown to affect circuit behavior in the spinal cord. In this review we will focus on the effects of neurotrophins, particularly nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), on spinal circuits. We also discuss evidence that these molecules can modify functions including nociceptive behavior, motor reflexes and stepping behavior. Since these substances and their receptors are normally present in the spinal cord, they could potentially be useful in improving function in disease states and after injury. Here we review recent findings relevant to these translational issues. PMID:24926235

  10. Introduction to lethal circuit transformations

    NASA Astrophysics Data System (ADS)

    Fišer, Petr; Schmidt, Jan

    2015-12-01

    Logic optimization is a process that takes a logic circuit description (Boolean network) as an input and tries to refine it, to reduce its size and/or depth. An ideal optimization process should be able to devise an optimum implementation of a network in a reasonable time, given any circuit structure at the input. However, there are cases where it completely fails to produce even near-optimum solutions. Such cases are typically induced by non-standard circuit structure modifications. Surprisingly enough, such deviated structures are frequently present in standard benchmark sets too. We may only wonder whether it is an intention of the benchmarks creators, or just an unlucky coincidence. Even though synthesis tools should be primarily well suited for practical circuits, there is no guarantee that, e.g., a higher-level synthesis process will not generate such unlucky structures. Here we present examples of circuit transformations that lead to failure of most of state-of-the-art logic synthesis and optimization processes, both academic and commercial, and suggest actions to mitigate the disturbing effects.

  11. Bioluminescent bioreporter integrated circuits (BBICs)

    NASA Astrophysics Data System (ADS)

    Simpson, Michael L.; Sayler, Gary S.; Nivens, David; Ripp, Steve; Paulus, Michael J.; Jellison, Gerald E.

    1998-07-01

    As the workhorse of the integrated circuit (IC) industry, the capabilities of CMOS have been expanded well beyond the original applications. The full spectrum of analog circuits from switched-capacitor filters to microwave circuit blocks, and from general-purpose operational amplifiers to sub- nanosecond analog timing circuits for nuclear physics experiments have been implemented in CMOS. This technology has also made in-roads into the growing area of monolithic sensors with devices such as active-pixel sensors and other electro-optical detection devices. While many of the processes used for MEMS fabrication are not compatible with the CMOS IC process, depositing a sensor material onto a previously fabricated CMOS circuit can create a very useful category of sensors. In this work we report a chemical sensor composed of bioluminescent bioreporters (genetically engineered bacteria) deposited onto a micro-luminometer fabricated in a standard CMOS IC process. The bioreporter used for this work emitted 490-nm light when exposed to toluene. This luminescence was detected by the micro- luminometer giving an indication of the concentration of toluene. Other bioluminescent bioreporters sensitive to explosives, mercury, and other organic chemicals and heavy metals have been reported. These could be incorporated (individually or in combination) with the micro-luminometer reported here to form a variety of chemical sensors.

  12. 49 CFR 236.5 - Design of control circuits on closed circuit principle.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Design of control circuits on closed circuit..., AND APPLIANCES Rules and Instructions: All Systems General § 236.5 Design of control circuits on closed circuit principle. All control circuits the functioning of which affects safety of train...

  13. 49 CFR 236.5 - Design of control circuits on closed circuit principle.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Design of control circuits on closed circuit..., AND APPLIANCES Rules and Instructions: All Systems General § 236.5 Design of control circuits on closed circuit principle. All control circuits the functioning of which affects safety of train...

  14. 30 CFR 77.506 - Electric equipment and circuits; overload and short-circuit protection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Electric equipment and circuits; overload and short-circuit protection. 77.506 Section 77.506 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... circuits; overload and short-circuit protection. Automatic circuit-breaking devices or fuses of the...

  15. 30 CFR 77.506 - Electric equipment and circuits; overload and short-circuit protection.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Electric equipment and circuits; overload and short-circuit protection. 77.506 Section 77.506 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... circuits; overload and short-circuit protection. Automatic circuit-breaking devices or fuses of the...

  16. 49 CFR 236.5 - Design of control circuits on closed circuit principle.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Design of control circuits on closed circuit..., AND APPLIANCES Rules and Instructions: All Systems General § 236.5 Design of control circuits on closed circuit principle. All control circuits the functioning of which affects safety of train...

  17. 30 CFR 77.506 - Electric equipment and circuits; overload and short-circuit protection.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Electric equipment and circuits; overload and short-circuit protection. 77.506 Section 77.506 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... circuits; overload and short-circuit protection. Automatic circuit-breaking devices or fuses of the...

  18. 30 CFR 75.518 - Electric equipment and circuits; overload and short circuit protection.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Equipment-General § 75.518 Electric equipment and circuits; overload and short circuit protection. Automatic... electric equipment and circuits against short circuit and overloads. Three-phase motors on all electric... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Electric equipment and circuits; overload...

  19. 49 CFR 236.5 - Design of control circuits on closed circuit principle.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Design of control circuits on closed circuit..., AND APPLIANCES Rules and Instructions: All Systems General § 236.5 Design of control circuits on closed circuit principle. All control circuits the functioning of which affects safety of train...

  20. 30 CFR 77.506 - Electric equipment and circuits; overload and short-circuit protection.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Electric equipment and circuits; overload and short-circuit protection. 77.506 Section 77.506 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... circuits; overload and short-circuit protection. Automatic circuit-breaking devices or fuses of the...