Science.gov

Sample records for distribution primary circuits

  1. Distributed circuit switching starnet

    SciTech Connect

    Chuan-lin Wu; Woei Lin; Min-chang Lin

    1982-01-01

    Starnet is a communication subnet which can cost-effectively connect hundreds or thousands of processors for distributed processing. It uses distributed control and circuit switching. Starnet's communication medium includes two major components: a multistage interconnection network and a set of interface units. The interconnection network uses a destination routing scheme with no central control. The interface unit provides handshaking between the computer/data node and the interconnection network under the control of a microprocessor. Detailed design of the communication medium is described. A model for comparing cost-effectiveness among starnet, crossbar and multiple buses is included. 7 references.

  2. Spatiotemporal dynamics of distributed synthetic genetic circuits

    NASA Astrophysics Data System (ADS)

    Kanakov, Oleg; Laptyeva, Tetyana; Tsimring, Lev; Ivanchenko, Mikhail

    2016-04-01

    We propose and study models of two distributed synthetic gene circuits, toggle-switch and oscillator, each split between two cell strains and coupled via quorum-sensing signals. The distributed toggle switch relies on mutual repression of the two strains, and oscillator is comprised of two strains, one of which acts as an activator for another that in turn acts as a repressor. Distributed toggle switch can exhibit mobile fronts, switching the system from the weaker to the stronger spatially homogeneous state. The circuit can also act as a biosensor, with the switching front dynamics determined by the properties of an external signal. Distributed oscillator system displays another biosensor functionality: oscillations emerge once a small amount of one cell strain appears amid the other, present in abundance. Distribution of synthetic gene circuits among multiple strains allows one to reduce crosstalk among different parts of the overall system and also decrease the energetic burden of the synthetic circuit per cell, which may allow for enhanced functionality and viability of engineered cells.

  3. Safety and performance enhancement circuit for primary explosive detonators

    DOEpatents

    Davis, Ronald W.

    2006-04-04

    A safety and performance enhancement arrangement for primary explosive detonators. This arrangement involves a circuit containing an energy storage capacitor and preset self-trigger to protect the primary explosive detonator from electrostatic discharge (ESD). The circuit does not discharge into the detonator until a sufficient level of charge is acquired on the capacitor. The circuit parameters are designed so that normal ESD environments cannot charge the protection circuit to a level to achieve discharge. When functioned, the performance of the detonator is also improved because of the close coupling of the stored energy.

  4. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 7 2013-07-01 2013-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  5. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 7 2012-07-01 2012-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  6. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 7 2011-07-01 2011-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  7. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  8. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  9. Distributed Amplifier Monolithic Microwave Integrated Circuit (MMIC) Design

    DTIC Science & Technology

    2012-10-01

    Distributed Amplifier Monolithic Microwave Integrated Circuit (MMIC) Design by John E. Penn ARL-TR-6237 October 2012...Distributed Amplifier Monolithic Microwave Integrated Circuit (MMIC) Design John E. Penn Sensors and Electron Devices Directorate, ARL...TITLE AND SUBTITLE Distributed Amplifier Monolithic Microwave Integrated Circuit (MMIC) Design 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c

  10. Tracing Particle Size Distribution Curves Using an Analogue Circuit.

    ERIC Educational Resources Information Center

    Bisschop, F. De; Segaert, O.

    1986-01-01

    Proposes an analog circuit for use in sedimentation analysis of finely divided solid materials. Discusses a method of particle size distribution analysis and provides schematics of the circuit with list of components as well as a discussion about the operation of the circuit. (JM)

  11. High Resolution PV Power Modeling for Distribution Circuit Analysis

    SciTech Connect

    Norris, B. L.; Dise, J. H.

    2013-09-01

    NREL has contracted with Clean Power Research to provide 1-minute simulation datasets of PV systems located at three high penetration distribution feeders in the service territory of Southern California Edison (SCE): Porterville, Palmdale, and Fontana, California. The resulting PV simulations will be used to separately model the electrical circuits to determine the impacts of PV on circuit operations.

  12. Cognitive Consilience: Primate Non-Primary Neuroanatomical Circuits Underlying Cognition

    PubMed Central

    Solari, Soren Van Hout; Stoner, Rich

    2011-01-01

    Interactions between the cerebral cortex, thalamus, and basal ganglia form the basis of cognitive information processing in the mammalian brain. Understanding the principles of neuroanatomical organization in these structures is critical to understanding the functions they perform and ultimately how the human brain works. We have manually distilled and synthesized hundreds of primate neuroanatomy facts into a single interactive visualization. The resulting picture represents the fundamental neuroanatomical blueprint upon which cognitive functions must be implemented. Within this framework we hypothesize and detail 7 functional circuits corresponding to psychological perspectives on the brain: consolidated long-term declarative memory, short-term declarative memory, working memory/information processing, behavioral memory selection, behavioral memory output, cognitive control, and cortical information flow regulation. Each circuit is described in terms of distinguishable neuronal groups including the cerebral isocortex (9 pyramidal neuronal groups), parahippocampal gyrus and hippocampus, thalamus (4 neuronal groups), basal ganglia (7 neuronal groups), metencephalon, basal forebrain, and other subcortical nuclei. We focus on neuroanatomy related to primate non-primary cortical systems to elucidate the basis underlying the distinct homotypical cognitive architecture. To display the breadth of this review, we introduce a novel method of integrating and presenting data in multiple independent visualizations: an interactive website (http://www.frontiersin.org/files/cognitiveconsilience/index.html) and standalone iPhone and iPad applications. With these tools we present a unique, annotated view of neuroanatomical consilience (integration of knowledge). PMID:22194717

  13. Behavior of stainless steels in pressurized water reactor primary circuits

    NASA Astrophysics Data System (ADS)

    Féron, D.; Herms, E.; Tanguy, B.

    2012-08-01

    Stainless steels are widely used in primary circuits of pressurized water reactors (PWRs). Operating experience with the various grades of stainless steels over several decades of years has generally been excellent. Nevertheless, stress corrosion failures have been reported in few cases. Two main factors contributing to SCC susceptibility enhancement are investigated in this study: cold work and irradiation. Irradiation is involved in the stress corrosion cracking and corrosion of in-core reactor components in PWR environment. Irradiated assisted stress corrosion cracking (IASCC) is a complex and multi-physics phenomenon for which a predictive modeling able to describe initiation and/or propagation is not yet achieved. Experimentally, development of initiation smart tests and of in situ instrumentation, also in nuclear reactors, is an important axis in order to gain a better understanding of IASCC kinetics. A strong susceptibility for SCC of heavily cold worked austenitic stainless steels is evidenced in hydrogenated primary water typical of PWRs. It is shown that for a given cold-working procedure, SCC susceptibility of austenitic stainless steels materials increases with increasing cold-work. Results have shown also strong influences of the cold work on the oxide layer composition and of the maximum stress on the time to fracture.

  14. Modeling the development of damage in BWR primary coolant circuits

    SciTech Connect

    Yeh, T.K.; Macdonald, D.D.

    1995-12-31

    Hydrogen water chemistry (HWC) has been explored as a remedial measure for inhibiting intergranular stress corrosion cracking (IGSCC), and for recently for mitigating irradiation assisted stress corrosion cracking (IASCC) in boiling water reactors over the past ten years. However, it is not clear if HWC can successfully protect all of the structural components in BWR primary heat transport circuits (HTCS) from IGSCC and LASCC. The authors have explored this issue using DAMAGE-PREDICTOR, which is a computer code that is capable of estimating the concentrations of radiolysis species, the electrochemical corrosion potential (ECP), and the growth rate of a reference crack in sensitized Type 304 stainless steel. This code was developed specifically for modeling the HTCs of BWRs. The primary objective of this code is to theoretically evaluate the effectiveness of HWC in BWRs as a function of feedwater hydrogen concentration and reactor power level. HWC simulations have been carried out for full power conditions for two reactors that differ markedly in their responses to HWC. It is found that DAMAGE-PREDICTOR can successfully account for plant data from both reactors using a single set of model parameter values.

  15. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    S.K. Kawatra; T.C. Eisele; H.J. Walqui

    2002-10-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing he product size distribution, so that the amount of excessively fine material produced can be minimized. This will save energy by reducing the amount of material that is ground below the target size, and will also reduce the quantity of materials wasted as ''slimes'' that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production. In the seventh quarter of this project, analysis of the plant operation identified sources of overgrinding in the circuit. Overgrinding was primarily caused by two effects: (1) The hydrocyclones used to close the circuit and remove fully-ground particles from the circuit were preferentially returning high-density ore particles to the secondary mills for regrinding even after they were already ground to pass the desired product size, and (2) The primary grinding mills were operating at less than full capacity, suggesting that a shift of grinding load to the primary mills could liberate more material before it reached the secondary mills, allowing more complete liberation with a coarser grind. Circuit modeling is underway to determine how best to modify the circuit to reduce these effects.

  16. 46 CFR 169.682 - Distribution and circuit loads.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Distribution and circuit loads. 169.682 Section 169.682 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Machinery and Electrical Electrical Installations Operating at Potentials of 50 Volts Or More on Vessels...

  17. 46 CFR 169.682 - Distribution and circuit loads.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Distribution and circuit loads. 169.682 Section 169.682 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Machinery and Electrical Electrical Installations Operating at Potentials of 50 Volts Or More on Vessels...

  18. 46 CFR 169.682 - Distribution and circuit loads.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Distribution and circuit loads. 169.682 Section 169.682 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Machinery and Electrical Electrical Installations Operating at Potentials of 50 Volts Or More on Vessels...

  19. 46 CFR 169.682 - Distribution and circuit loads.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Distribution and circuit loads. 169.682 Section 169.682 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Machinery and Electrical Electrical Installations Operating at Potentials of 50 Volts Or More on Vessels...

  20. Engine Tune-Up Service. Unit 3: Primary Circuit. Review Exercise Book. Automotive Mechanics Curriculum.

    ERIC Educational Resources Information Center

    Bacon, E. Miles

    This book of pretests and review exercises is designed to accompany the Engine Tune-Up Service Student Guide for Unit 3, Primary Circuit, available separately as CE 031 211. Focus of the exercises and pretests is testing the primary ignition circuit. Pretests and performance checklists are provided for each of the eight performance objectives…

  1. Engine Tune-Up Service. Unit 3: Primary Circuit. Posttests. Automotive Mechanics Curriculum.

    ERIC Educational Resources Information Center

    Morse, David T.

    This book of posttests is designed to accompany the Engine Tune-Up Service Student Guide for Unit 3, Primary Circuit, available separately as CE 031 211. Focus of the posttests is setting the primary ignition circuit. One multiple choice posttest is provided, covering the eight performance objectives contained in the unit. (No answer key is…

  2. Comparison of primary circuit piping radiation survey at Armenian NPPU-1 and 2

    SciTech Connect

    Kornitski, A.S.; Kasakov, V.A.; Lysenko, V.V.

    1993-12-31

    In 1990 a radiation survey of the primary circuit pipe equipment of the closed 1st and 2nd Armenian NPPU was fulfilled. The survey was carried out at the same points of the primary circuit pipes. This report compares dose rates which were measured 5cm from the equipment surface at the same points on both units.

  3. Comparison of primary circuit piping radiation survey at Armenian NPP-1 and -2

    SciTech Connect

    Kornitski, A.S.; KAsakov, V.A.; Lysenko, V.V.

    1993-12-31

    In 190 and 1991 a radiation survey of the primary circuit pipe equipment of the closed units at Armenian nuclear power plant was fulfilled. The survey was performed at the same points of the primary circuit pipes. Dose rates measured are described.

  4. Engine Tune-Up Service. Unit 3: Primary Circuit. Student Guide. Automotive Mechanics Curriculum.

    ERIC Educational Resources Information Center

    Bacon, E. Miles

    This student guide is for Unit 3, Primary Circuit, in the Engine Tune-Up Service portion of the Automotive Mechanics Curriculum. It deals with how to test the primary ignition circuit. A companion review exercise book and posttests are available separately as CE 031 212-213. An introduction tells how this unit fits into the total tune-up service,…

  5. HEMP interaction with an electric power distribution circuit. Final report

    SciTech Connect

    Zaininger, H.W.; Jaszewski, G.M.

    1985-08-01

    A high altitude nuclear burst, detonated at a height of 50 km or more, causes two types of electromagnetic pulses, high altitude EMP (HEMP) and magnetohydrodynamic EMP, which will interact with electric power systems. Previous work indicated that millions of miles of electric distribution systems in the United States may be especially vulnerable to HEMP incident simultaneously throughout large portions of the United States. Purpose of this work was to perform an initial assessment of HEMP induced surges on a simplified electric distribution system. This report presents the assumptions, methodology, and resulting induced transient voltages and currents at various points in the distribution circuit in the microsecond timeframe, considering the impacts of HEMP incident simultaneously throughout the distribution system for a range of parametric conditions. Results of this work suggest that EMP could induce voltage transients that far exceed the basic insulation level (BIL) of distribution systems and that a more detailed analysis is warranted.

  6. 30 CFR 77.501 - Electric distribution circuits and equipment; repair.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Electric distribution circuits and equipment... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.501 Electric distribution circuits and equipment; repair. No electrical work shall be performed on electric distribution circuits or...

  7. 30 CFR 77.501 - Electric distribution circuits and equipment; repair.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Electric distribution circuits and equipment... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.501 Electric distribution circuits and equipment; repair. No electrical work shall be performed on electric distribution circuits or...

  8. 30 CFR 77.501 - Electric distribution circuits and equipment; repair.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Electric distribution circuits and equipment... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.501 Electric distribution circuits and equipment; repair. No electrical work shall be performed on electric distribution circuits or...

  9. 30 CFR 77.501 - Electric distribution circuits and equipment; repair.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Electric distribution circuits and equipment... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.501 Electric distribution circuits and equipment; repair. No electrical work shall be performed on electric distribution circuits or...

  10. 30 CFR 77.501 - Electric distribution circuits and equipment; repair.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Electric distribution circuits and equipment... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.501 Electric distribution circuits and equipment; repair. No electrical work shall be performed on electric distribution circuits or...

  11. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    S.K. Kawatra; T.C. Eisele, H.J. Walqui

    2003-01-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing he product size distribution, so that the amount of excessively fine material produced can be minimized. This will save energy by reducing the amount of material that is ground below the target size, and will also reduce the quantity of materials wasted as ''slimes'' that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production. In previous quarters, it was determined that the primary grinding mills were operating at less than full capacity, suggesting that a shift of grinding load to the primary mills could liberate more material before it reached the secondary mills, allowing more complete liberation with a coarser grind. In the eighth quarter, further analysis was carried out to determine the full extent of the benefit that could be obtained by this shift in grinding load. A key part of this analysis was the development of a correlation of the circuit capacity with (a) ore work index, (b) the quantity of primary mill ''pebbles'' that were crushed by a cone crusher in the circuit, and (c) the fraction of the crushed pebbles that were also processed by a high-pressure roll mill.

  12. Multi-input distributed classifiers for synthetic genetic circuits.

    PubMed

    Kanakov, Oleg; Kotelnikov, Roman; Alsaedi, Ahmed; Tsimring, Lev; Huerta, Ramón; Zaikin, Alexey; Ivanchenko, Mikhail

    2015-01-01

    For practical construction of complex synthetic genetic networks able to perform elaborate functions it is important to have a pool of relatively simple modules with different functionality which can be compounded together. To complement engineering of very different existing synthetic genetic devices such as switches, oscillators or logical gates, we propose and develop here a design of synthetic multi-input classifier based on a recently introduced distributed classifier concept. A heterogeneous population of cells acts as a single classifier, whose output is obtained by summarizing the outputs of individual cells. The learning ability is achieved by pruning the population, instead of tuning parameters of an individual cell. The present paper is focused on evaluating two possible schemes of multi-input gene classifier circuits. We demonstrate their suitability for implementing a multi-input distributed classifier capable of separating data which are inseparable for single-input classifiers, and characterize performance of the classifiers by analytical and numerical results. The simpler scheme implements a linear classifier in a single cell and is targeted at separable classification problems with simple class borders. A hard learning strategy is used to train a distributed classifier by removing from the population any cell answering incorrectly to at least one training example. The other scheme implements a circuit with a bell-shaped response in a single cell to allow potentially arbitrary shape of the classification border in the input space of a distributed classifier. Inseparable classification problems are addressed using soft learning strategy, characterized by probabilistic decision to keep or discard a cell at each training iteration. We expect that our classifier design contributes to the development of robust and predictable synthetic biosensors, which have the potential to affect applications in a lot of fields, including that of medicine and industry.

  13. 30 CFR 75.511 - Low-, medium-, or high-voltage distribution circuits and equipment; repair.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Low-, medium-, or high-voltage distribution... Electrical Equipment-General § 75.511 Low-, medium-, or high-voltage distribution circuits and equipment; repair. No electrical work shall be performed on low-, medium-, or high-voltage distribution circuits...

  14. 30 CFR 75.511 - Low-, medium-, or high-voltage distribution circuits and equipment; repair.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Low-, medium-, or high-voltage distribution... Electrical Equipment-General § 75.511 Low-, medium-, or high-voltage distribution circuits and equipment; repair. No electrical work shall be performed on low-, medium-, or high-voltage distribution circuits...

  15. 30 CFR 75.511 - Low-, medium-, or high-voltage distribution circuits and equipment; repair.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Low-, medium-, or high-voltage distribution... Electrical Equipment-General § 75.511 Low-, medium-, or high-voltage distribution circuits and equipment; repair. No electrical work shall be performed on low-, medium-, or high-voltage distribution circuits...

  16. 30 CFR 75.511 - Low-, medium-, or high-voltage distribution circuits and equipment; repair.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Low-, medium-, or high-voltage distribution... Electrical Equipment-General § 75.511 Low-, medium-, or high-voltage distribution circuits and equipment; repair. No electrical work shall be performed on low-, medium-, or high-voltage distribution circuits...

  17. 30 CFR 75.511 - Low-, medium-, or high-voltage distribution circuits and equipment; repair.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Low-, medium-, or high-voltage distribution... Electrical Equipment-General § 75.511 Low-, medium-, or high-voltage distribution circuits and equipment; repair. No electrical work shall be performed on low-, medium-, or high-voltage distribution circuits...

  18. Primary blast injury causes cognitive impairments and hippocampal circuit alterations

    PubMed Central

    Beamer, Matthew; Tummala, Shanti R.; Gullotti, David; Kopil, Kathryn; Gorka, Samuel; Abel, Ted; “Dale” Bass, Cameron R.; Morrison, Barclay; Cohen, Akiva S.; Meaney, David F.

    2016-01-01

    Blast-induced traumatic brain injury (bTBI) and its long term consequences are a major health concern among veterans. Despite recent work enhancing our knowledge about bTBI, very little is known about the contribution of the blast wave alone to the observed sequelae. Herein, we isolated its contribution in a mouse model by constraining the animals' heads during exposure to a shockwave (primary blast). Our results show that exposure to primary blast alone results in changes in hippocampus-dependent behaviors that correspond with electro-physiological changes in area CA1 and are accompanied by reactive gliosis. Specifically, five days after exposure, behavior in an open field and performance in a spatial object recognition (SOR) task were significantly different from sham. Network electrophysiology, also performed five days after injury, demonstrated a significant decrease in excitability and increase in inhibitory tone. Immunohistochemistry for GFAP and Iba1 performed ten days after injury showed a significant increase in staining. Interestingly, a threefold increase in the impulse of the primary blast wave did not exacerbate these measures. However, we observed a significant reduction in the contribution of the NMDA receptors to the field EPSP at the highest blast exposure level. Our results emphasize the need to account for the effects of primary blast loading when studying the sequelae of bTBI. PMID:27246999

  19. Primary blast injury causes cognitive impairments and hippocampal circuit alterations.

    PubMed

    Beamer, Matthew; Tummala, Shanti R; Gullotti, David; Kopil, Catherine; Gorka, Samuel; Ted Abel; Bass, Cameron R Dale; Morrison, Barclay; Cohen, Akiva S; Meaney, David F

    2016-09-01

    Blast-induced traumatic brain injury (bTBI) and its long term consequences are a major health concern among veterans. Despite recent work enhancing our knowledge about bTBI, very little is known about the contribution of the blast wave alone to the observed sequelae. Herein, we isolated its contribution in a mouse model by constraining the animals' heads during exposure to a shockwave (primary blast). Our results show that exposure to primary blast alone results in changes in hippocampus-dependent behaviors that correspond with electrophysiological changes in area CA1 and are accompanied by reactive gliosis. Specifically, five days after exposure, behavior in an open field and performance in a spatial object recognition (SOR) task were significantly different from sham. Network electrophysiology, also performed five days after injury, demonstrated a significant decrease in excitability and increase in inhibitory tone. Immunohistochemistry for GFAP and Iba1 performed ten days after injury showed a significant increase in staining. Interestingly, a threefold increase in the impulse of the primary blast wave did not exacerbate these measures. However, we observed a significant reduction in the contribution of the NMDA receptors to the field EPSP at the highest blast exposure level. Our results emphasize the need to account for the effects of primary blast loading when studying the sequelae of bTBI.

  20. Capabilities and Testing of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    NASA Technical Reports Server (NTRS)

    Garber, Anne E.

    2007-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, is currently undergoing testing in the Early Flight Fission Test Facility (EFF-TF). Sodium potassium (NaK), which was used in the SNAP-10A fission reactor, was selected as the primary coolant. Basic circuit components include: simulated reactor core, NaK to gas heat exchanger, electromagnetic (EM) liquid metal pump, liquid metal flowmeter, load/drain reservoir, expansion reservoir, test section, and instrumentation. Operation of the circuit is based around a 37-pin partial-array core (pin and flow path dimensions are the same as those in a full core), designed to operate at 33 kWt. NaK flow rates of greater than 1 kg/sec may be achieved, depending upon the power applied to the EM pump. The heat exchanger provides for the removal of thermal energy from the circuit, simulating the presence of an energy conversion system. The presence of the test section increases the versatility of the circuit. A second liquid metal pump, an energy conversion system, and highly instrumented thermal simulators are all being considered for inclusion within the test section. This paper summarizes the capabilities and ongoing testing of the Fission Surface Power Primary Test Circuit (FSP-PTC).

  1. Evolution of a Family Nurse Practitioner Program to Improve Primary Care Distribution

    ERIC Educational Resources Information Center

    Andrus, Len Hughes; Fenley, Mary D.

    1976-01-01

    Describes a Family Nurse Practitioner Program that has effectively improved the distribution of primary health care manpower in rural areas. Program characteristics include selection of personnel from areas of need, decentralization of clinical and didactic training sites, competency-based portable curriculum, and circuit-riding institutionally…

  2. 46 CFR 169.682 - Distribution and circuit loads.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Machinery and Electrical Electrical Installations Operating at Potentials of 50 Volts Or More on Vessels of... be installed; or (2) 50 watts per outlet. (b) Circuits supplying electrical discharge lamps must...

  3. Primary thermometry triad at 6 mK in mesoscopic circuits

    NASA Astrophysics Data System (ADS)

    Iftikhar, Z.; Anthore, A.; Jezouin, S.; Parmentier, F. D.; Jin, Y.; Cavanna, A.; Ouerghi, A.; Gennser, U.; Pierre, F.

    2016-09-01

    Quantum physics emerge and develop as temperature is reduced. Although mesoscopic electrical circuits constitute an outstanding platform to explore quantum behaviour, the challenge in cooling the electrons impedes their potential. The strong coupling of such micrometre-scale devices with the measurement lines, combined with the weak coupling to the substrate, makes them extremely difficult to thermalize below 10 mK and imposes in situ thermometers. Here we demonstrate electronic quantum transport at 6 mK in micrometre-scale mesoscopic circuits. The thermometry methods are established by the comparison of three in situ primary thermometers, each involving a different underlying physics. The employed combination of quantum shot noise, quantum back action of a resistive circuit and conductance oscillations of a single-electron transistor covers a remarkably broad spectrum of mesoscopic phenomena. The experiment, performed in vacuum using a standard cryogen-free dilution refrigerator, paves the way towards the sub-millikelvin range with additional thermalization and refrigeration techniques.

  4. Mathematical simulation application for research of nonuniform distributed-parameter circuit transients

    NASA Astrophysics Data System (ADS)

    Kuleshova, E. O.; Plyusnin, A. A.; Shandarova, E. B.; Tikhomirova, O. V.

    2016-04-01

    This paper considers the simulation capability of nonuniform distributed-parameter circuit transients by using MatLab Simulink. This approach is capable of determining currents and voltages of nodes for power networks of any configurations and modes. The paper contains results of nonuniform line simulations in idle, short-circuit and load modes.

  5. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    S.K. Kawatra; T.C. Eisele; H.J. Walqui

    2002-07-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. This will save energy by reducing the amount of material that is ground below the target size, and will also reduce the quantity of materials wasted as slimes that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production. In the sixth quarter of this project, work was centered on analyzing the considerable plant data gathered during the first year of the project. Modeling is being carried out of the hydrocyclone portion of the grinding circuit, since this has been identified as the primary source of overgrinding and inefficiency.

  6. Quantum circuit for optimal eavesdropping in quantum key distribution using phase-time coding

    SciTech Connect

    Kronberg, D. A.; Molotkov, S. N.

    2010-07-15

    A quantum circuit is constructed for optimal eavesdropping on quantum key distribution proto- cols using phase-time coding, and its physical implementation based on linear and nonlinear fiber-optic components is proposed.

  7. A dedicated circuit links direction-selective retinal ganglion cells to the primary visual cortex

    NASA Astrophysics Data System (ADS)

    Cruz-Martín, Alberto; El-Danaf, Rana N.; Osakada, Fumitaka; Sriram, Balaji; Dhande, Onkar S.; Nguyen, Phong L.; Callaway, Edward M.; Ghosh, Anirvan; Huberman, Andrew D.

    2014-03-01

    How specific features in the environment are represented within the brain is an important unanswered question in neuroscience. A subset of retinal neurons, called direction-selective ganglion cells (DSGCs), are specialized for detecting motion along specific axes of the visual field. Despite extensive study of the retinal circuitry that endows DSGCs with their unique tuning properties, their downstream circuitry in the brain and thus their contribution to visual processing has remained unclear. In mice, several different types of DSGCs connect to the dorsal lateral geniculate nucleus (dLGN), the visual thalamic structure that harbours cortical relay neurons. Whether direction-selective information computed at the level of the retina is routed to cortical circuits and integrated with other visual channels, however, is unknown. Here we show that there is a di-synaptic circuit linking DSGCs with the superficial layers of the primary visual cortex (V1) by using viral trans-synaptic circuit mapping and functional imaging of visually driven calcium signals in thalamocortical axons. This circuit pools information from several types of DSGCs, converges in a specialized subdivision of the dLGN, and delivers direction-tuned and orientation-tuned signals to superficial V1. Notably, this circuit is anatomically segregated from the retino-geniculo-cortical pathway carrying non-direction-tuned visual information to deeper layers of V1, such as layer 4. Thus, the mouse harbours several functionally specialized, parallel retino-geniculo-cortical pathways, one of which originates with retinal DSGCs and delivers direction- and orientation-tuned information specifically to the superficial layers of the primary visual cortex. These data provide evidence that direction and orientation selectivity of some V1 neurons may be influenced by the activation of DSGCs.

  8. A dedicated circuit links direction-selective retinal ganglion cells to the primary visual cortex.

    PubMed

    Cruz-Martín, Alberto; El-Danaf, Rana N; Osakada, Fumitaka; Sriram, Balaji; Dhande, Onkar S; Nguyen, Phong L; Callaway, Edward M; Ghosh, Anirvan; Huberman, Andrew D

    2014-03-20

    How specific features in the environment are represented within the brain is an important unanswered question in neuroscience. A subset of retinal neurons, called direction-selective ganglion cells (DSGCs), are specialized for detecting motion along specific axes of the visual field. Despite extensive study of the retinal circuitry that endows DSGCs with their unique tuning properties, their downstream circuitry in the brain and thus their contribution to visual processing has remained unclear. In mice, several different types of DSGCs connect to the dorsal lateral geniculate nucleus (dLGN), the visual thalamic structure that harbours cortical relay neurons. Whether direction-selective information computed at the level of the retina is routed to cortical circuits and integrated with other visual channels, however, is unknown. Here we show that there is a di-synaptic circuit linking DSGCs with the superficial layers of the primary visual cortex (V1) by using viral trans-synaptic circuit mapping and functional imaging of visually driven calcium signals in thalamocortical axons. This circuit pools information from several types of DSGCs, converges in a specialized subdivision of the dLGN, and delivers direction-tuned and orientation-tuned signals to superficial V1. Notably, this circuit is anatomically segregated from the retino-geniculo-cortical pathway carrying non-direction-tuned visual information to deeper layers of V1, such as layer 4. Thus, the mouse harbours several functionally specialized, parallel retino-geniculo-cortical pathways, one of which originates with retinal DSGCs and delivers direction- and orientation-tuned information specifically to the superficial layers of the primary visual cortex. These data provide evidence that direction and orientation selectivity of some V1 neurons may be influenced by the activation of DSGCs.

  9. Primary thermometry triad at 6 mK in mesoscopic circuits

    PubMed Central

    Iftikhar, Z.; Anthore, A.; Jezouin, S.; Parmentier, F. D.; Jin, Y.; Cavanna, A.; Ouerghi, A.; Gennser, U.; Pierre, F.

    2016-01-01

    Quantum physics emerge and develop as temperature is reduced. Although mesoscopic electrical circuits constitute an outstanding platform to explore quantum behaviour, the challenge in cooling the electrons impedes their potential. The strong coupling of such micrometre-scale devices with the measurement lines, combined with the weak coupling to the substrate, makes them extremely difficult to thermalize below 10 mK and imposes in situ thermometers. Here we demonstrate electronic quantum transport at 6 mK in micrometre-scale mesoscopic circuits. The thermometry methods are established by the comparison of three in situ primary thermometers, each involving a different underlying physics. The employed combination of quantum shot noise, quantum back action of a resistive circuit and conductance oscillations of a single-electron transistor covers a remarkably broad spectrum of mesoscopic phenomena. The experiment, performed in vacuum using a standard cryogen-free dilution refrigerator, paves the way towards the sub-millikelvin range with additional thermalization and refrigeration techniques. PMID:27659941

  10. Distributed dynamical computation in neural circuits with propagating coherent activity patterns.

    PubMed

    Gong, Pulin; van Leeuwen, Cees

    2009-12-01

    Activity in neural circuits is spatiotemporally organized. Its spatial organization consists of multiple, localized coherent patterns, or patchy clusters. These patterns propagate across the circuits over time. This type of collective behavior has ubiquitously been observed, both in spontaneous activity and evoked responses; its function, however, has remained unclear. We construct a spatially extended, spiking neural circuit that generates emergent spatiotemporal activity patterns, thereby capturing some of the complexities of the patterns observed empirically. We elucidate what kind of fundamental function these patterns can serve by showing how they process information. As self-sustained objects, localized coherent patterns can signal information by propagating across the neural circuit. Computational operations occur when these emergent patterns interact, or collide with each other. The ongoing behaviors of these patterns naturally embody both distributed, parallel computation and cascaded logical operations. Such distributed computations enable the system to work in an inherently flexible and efficient way. Our work leads us to propose that propagating coherent activity patterns are the underlying primitives with which neural circuits carry out distributed dynamical computation.

  11. Development and Analysis of Cold Trap for Use in Fission Surface Power-Primary Test Circuit

    NASA Technical Reports Server (NTRS)

    Wolfe, T. M.; Dervan, C. A.; Pearson, J. B.; Godfroy, T. J.

    2012-01-01

    The design and analysis of a cold trap proposed for use in the purification of circulated eutectic sodium potassium (NaK-78) loops is presented. The cold trap is designed to be incorporated into the Fission Surface Power-Primary Test Circuit (FSP-PTC), which incorporates a pumped NaK loop to simulate in-space nuclear reactor-based technology using non-nuclear test methodology as developed by the Early Flight Fission-Test Facility. The FSP-PTC provides a test circuit for the development of fission surface power technology. This system operates at temperatures that would be similar to those found in a reactor (500-800 K). By dropping the operating temperature of a specified percentage of NaK flow through a bypass containing a forced circulation cold trap, the NaK purity level can be increased by precipitating oxides from the NaK and capturing them within the cold trap. This would prevent recirculation of these oxides back through the system, which may help prevent corrosion.

  12. Radiation protection performance for the dismantling of the WWR-M primary cooling circuit.

    PubMed

    Lobach, Yu N; Luferenko, E D; Shevel, V N

    2014-12-01

    The WWR-M is a light-water-cooled and moderated heterogonous research reactor with a thermal output of 10 MW. The reactor has been in operation for >50 y and has had an excellent safety record. A non-hermeticity of the inlet line of the primary cooling circuit (PCC) was found, and the only reasonable technical solution was the complete replacement of the PCC inlet and outlet pipe lines. Such a replacement was a challenging technical task due to the necessity to handle large size components with complex geometries under conditions of high-level radiation fields, and therefore, it required detailed planning aiming to reduce staff exposure. This paper describes the dismantling and removal of the PCC components focusing on radiation protection issues.

  13. Mechanisms of coordination in distributed neural circuits: encoding coordinating information.

    PubMed

    Smarandache-Wellmann, Carmen; Grätsch, Swantje

    2014-04-16

    We describe synaptic connections through which information essential for encoding efference copies reaches two coordinating neurons in each of the microcircuits that controls limbs on abdominal segments of the crayfish, Pacifastacus leniusculus. In each microcircuit, these coordinating neurons fire bursts of spikes simultaneously with motor neurons. These bursts encode timing, duration, and strength of each motor burst. Using paired microelectrode recordings, we demonstrate that one class of nonspiking neurons in each microcircuit's pattern-generating kernel--IPS--directly inhibits the ASCE coordinating neuron that copies each burst in power-stroke (PS) motor neurons. This inhibitory synapse parallels IPS's inhibition of the same PS motor neurons. Using a disynaptic pathway to control its membrane potential, we demonstrate that a second type of nonspiking interneuron in the pattern-generating kernel--IRSh--inhibits the DSC coordinating neuron that copies each burst in return-stroke (RS) motor neurons. This inhibitory synapse parallels IRS's inhibition of the microcircuit's RS motor neurons. Experimental changes in the membrane potential of one IPS or one IRSh neuron simultaneously changed the strengths of motor bursts, durations, numbers of spikes, and spike frequency in the simultaneous ASCE and DSC bursts. ASCE and DSC coordinating neurons link the segmentally distributed microcircuits into a coordinated system that oscillates with the same period and with stable phase differences. The inhibitory synapses from different pattern-generating neurons that parallel their inhibition of different sets of motor neurons enable ASCE and DSC to encode details of each oscillation that are necessary for stable, adaptive synchronization of the system.

  14. Formulating a simplified equivalent representation of distribution circuits for PV impact studies.

    SciTech Connect

    Reno, Matthew J.; Broderick, Robert Joseph; Grijalva, Santiago

    2013-04-01

    With an increasing number of Distributed Generation (DG) being connected on the distribution system, a method for simplifying the complexity of the distribution system to an equivalent representation of the feeder is advantageous for streamlining the interconnection study process. The general characteristics of the system can be retained while reducing the modeling effort required. This report presents a method of simplifying feeders to only specified buses-of-interest. These buses-of-interest can be potential PV interconnection locations or buses where engineers want to verify a certain power quality. The equations and methodology are presented with mathematical proofs of the equivalence of the circuit reduction method. An example 15-bus feeder is shown with the parameters and intermediate example reduction steps to simplify the circuit to 4 buses. The reduced feeder is simulated using PowerWorld Simulator to validate that those buses operate with the same characteristics as the original circuit. Validation of the method is also performed for snapshot and time-series simulations with variable load and solar energy output data to validate the equivalent performance of the reduced circuit with the interconnection of PV.

  15. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    S.K. Kawatra; T.C. Eisele; T. Weldum; D. Larsen; R. Mariani; J. Pletka

    2005-01-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. The goal is to save energy by reducing the amount of material that is ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that are too fine to be useful. This is being accomplished by mathematical modeling of the grinding circuits to determine how to correct this problem. The approaches taken included (1) Modeling of the circuit to determine process bottlenecks that restrict flowrates in one area while forcing other parts of the circuit to overgrind the material; (2) Modeling of hydrocyclones to determine the mechanisms responsible for retaining fine, high-density particles in the circuit until they are overground, and improving existing models to accurately account for this behavior; and (3) Evaluation of advanced technologies to improve comminution efficiency and produce sharper product size distributions with less overgrinding.

  16. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    T.C. Eisele; S.K. Kawatra; H.J. Walqui

    2004-10-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. The goal is to save energy by reducing the amount of material that is ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that are too fine to be useful. This is being accomplished by mathematical modeling of the grinding circuits to determine how to correct this problem. The approaches taken included (1) Modeling of the circuit to determine process bottlenecks that restrict flowrates in one area while forcing other parts of the circuit to overgrind the material; (2) Modeling of hydrocyclones to determine the mechanisms responsible for retaining fine, high-density particles in the circuit until they are overground, and improving existing models to accurately account for this behavior; and (3) Evaluation of advanced technologies to improve comminution efficiency and produce sharper product size distributions with less overgrinding.

  17. Optimization of Comminution Circuit Throughput and Product Size Distribution by Simulation and Control

    SciTech Connect

    S. K. Kawatra; T. C. Eisele; T. Weldum; D. Larsen; R. Mariani; J. Pletka

    2005-03-31

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. The goal is to save energy by reducing the amount of material that is ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that are too fine to be useful. This is being accomplished by mathematical modeling of the grinding circuits to determine how to correct this problem. The approaches taken included (1) Modeling of the circuit to determine process bottlenecks that restrict flow rates in one area while forcing other parts of the circuit to overgrind the material; (2) Modeling of hydrocyclones to determine the mechanisms responsible for retaining fine, high-density particles in the circuit until they are overground, and improving existing models to accurately account for this behavior; and (3) Evaluation of advanced technologies to improve comminution efficiency and produce sharper product size distributions with less overgrinding.

  18. Accounting for a feature of the configuration of the loops in the primary circuit of VVER-440 reactors

    SciTech Connect

    Khazanov, A. L.

    2013-09-15

    A feature of the configuration of the loops of the primary circuit of VVER-440 reactors and its influence on the characteristics of the main circulation pumps are analyzed. It is proposed that differences in the characteristics of the main reactor circulation pumps be taken account during the design and operation of nuclear power plants.

  19. Project Work as a Vehicle for Information Literacy Education in a Circuit of South African Primary Schools.

    ERIC Educational Resources Information Center

    Hart, Genevieve

    This paper reports on a two-month study of the information literacy of 26 grade seven teachers within a circuit of 17 primary schools in Cape Town (South Africa), comprising three historically advantaged schools situated in a historically white suburb and 14 disadvantaged schools in adjacent historically black townships. The focus of the study is…

  20. Optimization of Comminution Circuit Throughput and Product Size Distribution by Simulation and Control

    SciTech Connect

    S.K. Kawatra; T.C. Eisele; T. Weldum; D. Larsen; R. Mariani; J. Pletka

    2005-07-01

    The goal of this project was to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process were used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced could be minimized. The goal was to save energy by reducing the amount of material that was ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that were too fine to be useful. Extensive plant sampling and mathematical modeling of the grinding circuits was carried out to determine how to correct this problem. The approaches taken included (1) Modeling of the circuit to determine process bottlenecks that restrict flowrates in one area while forcing other parts of the circuit to overgrind the material; (2) Modeling of hydrocyclones to determine the mechanisms responsible for retaining fine, high-density particles in the circuit until they are overground, and improving existing models to accurately account for this behavior; and (3) Evaluation of the potential of advanced technologies to improve comminution efficiency and produce sharper product size distributions with less overgrinding. The mathematical models were used to simulate novel circuits for minimizing overgrinding and increasing throughput, and it is estimated that a single plant grinding 15 million tons of ore per year saves up to 82.5 million kWhr/year, or 8.6 x 10{sup 11} BTU/year. Implementation of this technology in the midwestern iron ore industry, which grinds an estimated 150 million tons of ore annually to produce over 50 million tons of iron ore concentrate, would save an estimated 1 x 10{sup 13} BTU/year.

  1. A fast cholinergic modulation of the primary acoustic startle circuit in rats.

    PubMed

    Gómez-Nieto, Ricardo; Sinex, Donal G; Horta-Júnior, José de Anchieta C; Castellano, Orlando; Herrero-Turrión, Javier M; López, Dolores E

    2014-09-01

    Cochlear root neurons (CRNs) are the first brainstem neurons which initiate and participate in the full expression of the acoustic startle reflex. Although it has been suggested that a cholinergic pathway from the ventral nucleus of the trapezoid body (VNTB) conveys auditory prepulses to the CRNs, the neuronal origin of the VNTB-CRNs projection and the role it may play in the cochlear root nucleus remain uncertain. To determine the VNTB neuronal type which projects to CRNs, we performed tract-tracing experiments combined with mechanical lesions, and morphometric analyses. Our results indicate that a subpopulation of non-olivocochlear neurons projects directly and bilaterally to CRNs via the trapezoid body. We also performed a gene expression analysis of muscarinic and nicotinic receptors which indicates that CRNs contain a cholinergic receptor profile sufficient to mediate the modulation of CRN responses. Consequently, we investigated the effects of auditory prepulses on the neuronal activity of CRNs using extracellular recordings in vivo. Our results show that CRN responses are strongly inhibited by auditory prepulses. Unlike other neurons of the cochlear nucleus, the CRNs exhibited inhibition that depended on parameters of the auditory prepulse such as intensity and interstimulus interval, showing their strongest inhibition at short interstimulus intervals. In sum, our study supports the idea that CRNs are involved in the auditory prepulse inhibition of the acoustic startle reflex, and confirms the existence of multiple cholinergic pathways that modulate the primary acoustic startle circuit.

  2. Effects of molybdenum and silver on iodine transport in primary circuit on severe nuclear accidents

    SciTech Connect

    Kalilainen, J.; Rantanen, P.; Karkela, T.; Lipponen, M.; Auvinen, A.; Jokiniemi, J.

    2012-07-01

    This experimental study was a continuation of the study conducted at VTT to investigate the effects of reactions on primary circuit surfaces to transport of gaseous and aerosol phase iodine during the hypothetical severe nuclear accident. Cesium iodide was used as a precursor in every experiment. In the experiments it was observed that the hydrogen in the atmosphere decreased the fraction of released gaseous iodine. As the temperature was lowered, less iodine was released, but the fraction of gaseous iodine from the overall released iodine was increased. As molybdenum trioxide was introduced to the precursor, the fraction of gaseous iodine from the overall released iodine was increased significantly. Also, Mo decreased the transport of Cs and caused significant depositions to the reaction furnace. Addition of silver to the CsI precursor at 650 deg. C decreased the release of iodine as well as the fraction of gaseous iodine. At 400 deg. C, Ag + CsI as well as Ag + MoO{sub 3} + CsI precursor significantly increased the release of gaseous iodine, where almost no aerosol particles were released. With B{sub 2}O{sub 3} + CsI precursor it was observed that in the atmosphere without H{sub 2}O, the released iodine was mostly in gaseous form. (authors)

  3. The primary visual cortex in the neural circuit for visual orienting

    NASA Astrophysics Data System (ADS)

    Zhaoping, Li

    The primary visual cortex (V1) is traditionally viewed as remote from influencing brain's motor outputs. However, V1 provides the most abundant cortical inputs directly to the sensory layers of superior colliculus (SC), a midbrain structure to command visual orienting such as shifting gaze and turning heads. I will show physiological, anatomical, and behavioral data suggesting that V1 transforms visual input into a saliency map to guide a class of visual orienting that is reflexive or involuntary. In particular, V1 receives a retinotopic map of visual features, such as orientation, color, and motion direction of local visual inputs; local interactions between V1 neurons perform a local-to-global computation to arrive at a saliency map that highlights conspicuous visual locations by higher V1 responses. The conspicuous location are usually, but not always, where visual input statistics changes. The population V1 outputs to SC, which is also retinotopic, enables SC to locate, by lateral inhibition between SC neurons, the most salient location as the saccadic target. Experimental tests of this hypothesis will be shown. Variations of the neural circuit for visual orienting across animal species, with more or less V1 involvement, will be discussed. Supported by the Gatsby Charitable Foundation.

  4. Estimation of Operating Condition of Appliances Using Circuit Current Data on Electric Distribution Boards

    NASA Astrophysics Data System (ADS)

    Iwafune, Yumiko; Ogimoto, Kazuhiko; Yagita, Yoshie

    The Energy management systems (EMS) on demand sides are expected as a method to enhance the capability of supply and demand balancing of a power system under the anticipated penetration of renewable energy generation such as Photovoltaics (PV). Elucidation of energy consumption structure in a building is one of important elements for realization of EMS and contributes to the extraction of potential energy saving. In this paper, we propose the estimation method of operating condition of household appliances using circuit current data on an electric distribution board. Circuit current data are broken down by their shape using a self-organization map method and aggregated by appliance based on customers' information of appliance possessed. Proposed method is verified using residential energy consumption measurement survey data.

  5. Effects of aging on properties of the local circuit in rat primary somatosensory cortex (S1) in vitro.

    PubMed

    Hickmott, Peter; Dinse, Hubert

    2013-10-01

    During aging receptive field properties degrade, the ability of the circuit to process temporal information is impaired and behaviors mediated by the circuit can become impaired. These changes are mediated by changes in the properties of neural circuits, particularly the balance of excitation and inhibition, the intrinsic properties of neurons, and the anatomy of connections in the circuit. In this study, properties of thalamorecipient pyramidal neurons in layer 3 were examined in the hindpaw region of rat primary somatosensory cortex (S1) in vitro. Excitatory and inhibitory postsynaptic currents (IPSCs) resulting from trains of electrical stimulation of thalamocortical afferents were recorded. Excitatory postsynaptic currents were larger in old S1, but showed no difference in temporal dynamics; IPSCs showed significantly less suppression across the train in old S1, partly due to a decrease in GABAB signaling. Neurons in old S1 were more likely to exhibit burst firing, due to an increase in T-current. Significant differences in dendritic morphology were also observed in old S1, accompanied by a decrease in dendritic spine density. These data directly demonstrate changes in the properties of the thalamorecipient circuit in old S1 and help to explain the changes observed in responses during aging.

  6. Multiple components of surround modulation in primary visual cortex: multiple neural circuits with multiple functions?

    PubMed

    Nurminen, Lauri; Angelucci, Alessandra

    2014-11-01

    The responses of neurons in primary visual cortex (V1) to stimulation of their receptive field (RF) are modulated by stimuli in the RF surround. This modulation is suppressive when the stimuli in the RF and surround are of similar orientation, but less suppressive or facilitatory when they are cross-oriented. Similarly, in human vision surround stimuli selectively suppress the perceived contrast of a central stimulus. Although the properties of surround modulation have been thoroughly characterized in many species, cortical areas and sensory modalities, its role in perception remains unknown. Here we argue that surround modulation in V1 consists of multiple components having different spatio-temporal and tuning properties, generated by different neural circuits and serving different visual functions. One component arises from LGN afferents, is fast, untuned for orientation, and spatially restricted to the surround region nearest to the RF (the near-surround); its function is to normalize V1 cell responses to local contrast. Intra-V1 horizontal connections contribute a slower, narrowly orientation-tuned component to near-surround modulation, whose function is to increase the coding efficiency of natural images in manner that leads to the extraction of object boundaries. The third component is generated by topdown feedback connections to V1, is fast, broadly orientation-tuned, and extends into the far-surround; its function is to enhance the salience of behaviorally relevant visual features. Far- and near-surround modulation, thus, act as parallel mechanisms: the former quickly detects and guides saccades/attention to salient visual scene locations, the latter segments object boundaries in the scene.

  7. Multiple components of surround modulation in primary visual cortex: multiple neural circuits with multiple functions?

    PubMed Central

    Nurminen, Lauri; Angelucci, Alessandra

    2014-01-01

    The responses of neurons in primary visual cortex (V1) to stimulation of their receptive field (RF) are modulated by stimuli in the RF surround. This modulation is suppressive when the stimuli in the RF and surround are of similar orientation, but less suppressive or facilitatory when they are cross-oriented. Similarly, in human vision surround stimuli selectively suppress the perceived contrast of a central stimulus. Although the properties of surround modulation have been thoroughly characterized in many species, cortical areas and sensory modalities, its role in perception remains unknown. Here we argue that surround modulation in V1 consists of multiple components having different spatio-temporal and tuning properties, generated by different neural circuits and serving different visual functions. One component arises from LGN afferents, is fast, untuned for orientation, and spatially restricted to the surround region nearest to the RF (the near-surround); its function is to normalize V1 cell responses to local contrast. Intra-V1 horizontal connections contribute a slower, narrowly orientation-tuned component to near-surround modulation, whose function is to increase the coding efficiency of natural images in manner that leads to the extraction of object boundaries. The third component is generated by topdown feedback connections to V1, is fast, broadly orientation-tuned, and extends into the far-surround; its function is to enhance the salience of behaviorally relevant visual features. Far- and near-surround modulation, thus, act as parallel mechanisms: the former quickly detects and guides saccades/attention to salient visual scene locations, the latter segments object boundaries in the scene. PMID:25204770

  8. The modelling of carbon-based supercapacitors: Distributions of time constants and Pascal Equivalent Circuits

    NASA Astrophysics Data System (ADS)

    Fletcher, Stephen; Kirkpatrick, Iain; Dring, Roderick; Puttock, Robert; Thring, Rob; Howroyd, Simon

    2017-03-01

    Supercapacitors are an emerging technology with applications in pulse power, motive power, and energy storage. However, their carbon electrodes show a variety of non-ideal behaviours that have so far eluded explanation. These include Voltage Decay after charging, Voltage Rebound after discharging, and Dispersed Kinetics at long times. In the present work, we establish that a vertical ladder network of RC components can reproduce all these puzzling phenomena. Both software and hardware realizations of the network are described. In general, porous carbon electrodes contain random distributions of resistance R and capacitance C, with a wider spread of log R values than log C values. To understand what this implies, a simplified model is developed in which log R is treated as a Gaussian random variable while log C is treated as a constant. From this model, a new family of equivalent circuits is developed in which the continuous distribution of log R values is replaced by a discrete set of log R values drawn from a geometric series. We call these Pascal Equivalent Circuits. Their behaviour is shown to resemble closely that of real supercapacitors. The results confirm that distributions of RC time constants dominate the behaviour of real supercapacitors.

  9. Primary migration within the Querecual formation: Distribution of biomarkers

    SciTech Connect

    Lopez, L.; Sequera, Z.; Galarraga, F.

    1996-08-01

    Variations in the distribution of biomarkers (steranes and terpanes) as the consequences of primary migration were studied in limestone samples of the type section of the Querecual Formation, Venezuela. These variations were compared with conventional parameters of primary migration such as, variations in concentrations of bitumen, its fractions (saturated hydrocarbons, aromatic hydrocarbons, resins and asphaltene), and the n-alkane distribution. Biomarkers; (steranes and terpanes) show variations along the stratigraphic section that allow the suggestion of the following relative mobility of compounds in the consequence of their primary migration: Tricyclic Terpanes > regular Steranes =(approx.)= Rearranged Steranes > Pentacyclic Terpanes. Variations of bitumen fractions indicate a greater mobility of saturated and aromatic hydrocarbons vs. resins and asphaltenes, and variations in the n-alkane distribution indicate a relative greater migration of the light n-alkanes (n-C{sub 20}). These results indicate that primary migration was controlled by the molecular weight and structure of bitumen constituents. The migration tendencies of all geochemical parameters studied point to a vertical migration from the center toward the top and bottom of the type section of the Querecual Formation.

  10. Applying wind turbines and battery storage to defer Orcas Power and Light Company distribution circuit upgrades

    SciTech Connect

    Zaininger, H.W.; Barnes, P.R.

    1997-03-01

    The purpose of this study is to conduct a detailed assessment of the Orcas Power and Light Company (OPALCO) system to determine the potential for deferring the costly upgrade of the 25-kV Lopez- Eastsound circuit, by the application of a MW-scale wind farm and battery storage facilities as appropriate. Local wind resource data has been collected over the past year and used to determine MW-scale wind farm performance. This hourly wind farm performance data is used with measured hourly Eastsound load data, and recent OPALCO distribution system expansion plans and cost projections in performing this detailed benefit-cost assessment. The OPALCO distribution circuit expansion project and assumptions are described. MW-scale wind farm performance results are given. The economic benefit-cost results for the wind farm and battery storage applications on the OPALCO system using OPALCO system design criteria and cost assumptions are reported. A recalculation is presented of the benefit-cost results for similar potential wind farm and battery storage applications on other utility systems with higher marginal energy and demand costs. Conclusions and recommendations are presented.

  11. Closed Form Formulas for Distributed Circuit Model of Discontinuities in HTS Microstrip Transmission Lines

    NASA Astrophysics Data System (ADS)

    Javadzadeh, S. Mohammad Hassan; Mamaghany, Zahra Mardy; Farzaneh, Forouhar; Fardmanesh, Mehdi

    A distributed circuit model for different kinds of discontinuities in high temperature superconducting (HTS) microstrip transmission lines (TLs), is proposed. In each case, closed form formula for lumped element model is presented based on the configuration of the discontinuity and the characterizations of HTS microstrip TLs. These discontinuities consist of steps in width, open ends, gaps and 90-degree bends. In the case of normal conductor microstrip TLs there are a lot of numerical and analytical equations that can accurately model them, however those formulas are not efficient for HTS TLs. Thus modified relations are extracted utilizing the superconducting characterizations to obtain much more accurate formulas. Additionally temperature dependence of HTS TLs is considered in the relations. Moreover regarding the kinetic inductance in HTS TLs a closed form formula is proposed for characteristic impedance of HTS TLs. Furthermore correction factors based on fringe fields is used to optimize all formulas. Using these formulations can lead to modeling and analysis of some superconducting microwave devices such as resonators, microwave filters, couplers, etc. In contrast to EM analysis, using the distributed circuit model is much easier for analysis of HTS microwave devices. The accuracy of the proposed model is confirmed in comparison with some electromagnetic full-wave simulations. This full analytical approach shows great accuracy in this test case as well.

  12. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    H.J. Walqui; T.C. Eisele; S.K. Kawatra

    2003-04-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. The goal is to save energy by reducing the amount of material that is ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production. During this quarter, work was focused on three areas: (1) The mathematical relationship developed for predicting plant throughput was improved, based on ore work index and equipment parameters measured in the plant over an extended period. It was determined that the model would need to fit two distinct regimes of grinding circuit operation, depending on the work index of the feed ore. (2) Plans for a proposed change in the circuit configuration at an iron ore plant are being made, to test predictions based on the work done to date in the project. After determining the desired circuit change, which would require screening a portion of the grinding slurry, samples were sent to an industrial screen manufacturer for pilot plant scale testing. These tests indicated that the screening could be carried out economically, and plans are proceeding to conduct trials of the proposed circuit alteration. (2) The mathematical model used for hydrocyclone simulations was found to be unable to fully predict the ''fish-hook'' behavior that is seen in the plant samples. The model was therefore improved by including empirically-determined terms so that it would be able to account for

  13. Modifications to the Fission Surface Power Primary Test Circuit (FSP-PTC)

    NASA Technical Reports Server (NTRS)

    Garber, Anne E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of a closeable orifice in the test section. Modifications are now complete and testing has resumed. Performance of the ALIp, provided by Idaho National Laboratory (INL), is the subject of the first round ofexperimentation. This paper provides a summary of the tests conducted on the original circuit, details the physical changes that have since been made to it, and describes the current test program.

  14. Competition with Primary Sensory Afferents Drives Remodeling of Corticospinal Axons in Mature Spinal Motor Circuits

    PubMed Central

    Jiang, Yu-Qiu; Zaaimi, Boubker

    2016-01-01

    Injury to the mature motor system drives significant spontaneous axonal sprouting instead of axon regeneration. Knowing the circuit-level determinants of axonal sprouting is important for repairing motor circuits after injury to achieve functional rehabilitation. Competitive interactions are known to shape corticospinal tract axon outgrowth and withdrawal during development. Whether and how competition contributes to reorganization of mature spinal motor circuits is unclear. To study this question, we examined plastic changes in corticospinal axons in response to two complementary proprioceptive afferent manipulations: (1) enhancing proprioceptive afferents activity by electrical stimulation; or (2) diminishing their input by dorsal rootlet rhizotomy. Experiments were conducted in adult rats. Electrical stimulation produced proprioceptive afferent sprouting that was accompanied by significant corticospinal axon withdrawal and a decrease in corticospinal connections on cholinergic interneurons in the medial intermediate zone and C boutons on motoneurons. In contrast, dorsal rootlet rhizotomy led to a significant increase in corticospinal connections, including those on cholinergic interneurons; C bouton density increased correspondingly. Motor cortex-evoked muscle potentials showed parallel changes to those of corticospinal axons, suggesting that reciprocal corticospinal axon changes are functional. Using the two complementary models, we showed that competitive interactions between proprioceptive and corticospinal axons are an important determinant in the organization of mature corticospinal axons and spinal motor circuits. The activity- and synaptic space-dependent properties of the competition enables prediction of the remodeling of spared corticospinal connection and spinal motor circuits after injury and informs the target-specific control of corticospinal connections to promote functional recovery. SIGNIFICANCE STATEMENT Neuroplasticity is limited in maturity

  15. Fuzzy logic applications for failure analysis and diagnosis of a primary circuit of the HTR nuclear power plant

    NASA Astrophysics Data System (ADS)

    Kitowski, J.; Ksiażek, E.

    1985-10-01

    The paper presents some preliminary results of diagnostic analysis of the stimulated primary circuit of the THTR-300 nuclear power plant, based on the fuzzy sets theory. Two methods are used: the solution of the fuzzy relational equations and its extension to fuzzy logic. The first stage of the diagnostic system is the identification of the plant in the sense of fuzzy relations and the second stage is the failure or disturbance recognition. According to the fuzzy logic, lower and upper bounds of the failure vectors are obtained. Such an expert system can supply the operator in a correct recognition of the current state of the complex plant.

  16. Application of the leak-before-break concept to the primary circuit piping of the Leningrad NPP

    SciTech Connect

    Eperin, A.P.; Zakharzhevsky, Yu.O.; Arzhaev, A.I.

    1997-04-01

    A two-year Finnish-Russian cooperation program has been initiated in 1995 to demonstrate the applicability of the leak-before-break concept (LBB) to the primary circuit piping of the Leningrad NPP. The program includes J-R curve testing of authentic pipe materials at full operating temperature, screening and computational LBB analyses complying with the USNRC Standard Review Plan 3.6.3, and exchange of LBB-related information with emphasis on NDE. Domestic computer codes are mainly used, and all tests and analyses are independently carried out by each party. The results are believed to apply generally to RBMK type plants of the first generation.

  17. Recent Updates to the Fission Surface Power Primary Test Circuit (FSP-PTC)

    NASA Technical Reports Server (NTRS)

    Garber, Anne E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of a closeable orifice in the test section. Modifications are now complete and testing has resumed. Performance of the ALIP, provided by Idaho National Laboratory (1NL), is the subject of the first round of experimentation. This presentation details the physical changes made to the FSP-PTC and the current test program.

  18. Modifications and Modeling of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    NASA Technical Reports Server (NTRS)

    Garber, Anne E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of a closeable orifice in the test section. Performance of the ALIP, provided by Idaho National Laboratory (INL), will be evaluated when testing resumes. Data from the first round of testing has been used to refine the working system model, developed using the Generalized Fluid System Simulation Program (GFSSP). This paper covers the modifications of the FSP-PTC and the updated GFSSP system model.

  19. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    H.J. Walqui; T.C. Eisele; S.K. Kawatra

    2003-07-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. The goal is to save energy by reducing the amount of material that is ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production.

  20. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHOUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    H.J. Walqui; T.C. Eisele; S.K. Kawatra

    2004-01-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. The goal is to save energy by reducing the amount of material that is ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production.

  1. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    H.J. Walqui, T.C. Eisele, S.K. Kawatra

    2004-04-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. The goal is to save energy by reducing the amount of material that is ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production.

  2. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHOUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    H.J. Walqui; T.C. Eisele; S.K. Kawatra

    2003-10-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. The goal is to save energy by reducing the amount of material that is ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding and maximizing energy efficiency, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production.

  3. Contribution of polymers to classical primary insulation of distribution system

    SciTech Connect

    Shwehdi, M.H.; Al-Rawi, A.

    1996-12-31

    Insulation composites used on present distribution lines frequently consist of several types of materials such as wood, porcelain, polymers and fiberglass reinforced plastics (FRP) connected in series. A study included the laboratory determination of the critical flashover voltage (CFO) of 17 single component and 90 combinations of two components were conducted. The acquired data were used to develop methods of predicting CFO levels of various multiple series electrical insulations. This paper illustrates the results and analyses of the classical primary insulation (porcelain), and of the modern-day insulation of polymers. It also presents the result of whether polymers may add or supplement insulation strength to the two dielectric combination using statistical methods. The paper also presents advantages and guidelines for the use of polymers to either replace or complement porcelain. This may help optimize the choice of dielectrics on distribution lines.

  4. Vision loss shifts the balance of feedforward and intracortical circuits in opposite directions in mouse primary auditory and visual cortices.

    PubMed

    Petrus, Emily; Rodriguez, Gabriela; Patterson, Ryan; Connor, Blaine; Kanold, Patrick O; Lee, Hey-Kyoung

    2015-06-10

    Loss of a sensory modality leads to widespread changes in synaptic function across sensory cortices, which are thought to be the basis for cross-modal adaptation. Previous studies suggest that experience-dependent cross-modal regulation of the spared sensory cortices may be mediated by changes in cortical circuits. Here, we report that loss of vision, in the form of dark exposure (DE) for 1 week, produces laminar-specific changes in excitatory and inhibitory circuits in the primary auditory cortex (A1) of adult mice to promote feedforward (FF) processing and also strengthens intracortical inputs to primary visual cortex (V1). Specifically, DE potentiated FF excitatory synapses from layer 4 (L4) to L2/3 in A1 and recurrent excitatory inputs in A1-L4 in parallel with a reduction in the strength of lateral intracortical excitatory inputs to A1-L2/3. This suggests a shift in processing in favor of FF information at the expense of intracortical processing. Vision loss also strengthened inhibitory synaptic function in L4 and L2/3 of A1, but via laminar specific mechanisms. In A1-L4, DE specifically potentiated the evoked synaptic transmission from parvalbumin-positive inhibitory interneurons to principal neurons without changes in spontaneous miniature IPSCs (mIPSCs). In contrast, DE specifically increased the frequency of mIPSCs in A1-L2/3. In V1, FF excitatory inputs were unaltered by DE, whereas lateral intracortical connections in L2/3 were strengthened, suggesting a shift toward intracortical processing. Our results suggest that loss of vision produces distinct circuit changes in the spared and deprived sensory cortices to shift between FF and intracortical processing to allow adaptation.

  5. Numerical Investigation of Thermal Stratification in the Primary Circuit of VVER-440 Type Reactors

    SciTech Connect

    Boros, Ildiko; Aszodi, Attila; Legradi, Gabor

    2006-07-01

    Thermal stratification in the primary loops and in the connected pipes can limit the lifetime of the piping, or lead to penetrating cracks due to the stresses caused by the temperature differences and the cyclic temperature changes. Therefore it is essential to determine the thermal hydraulic parameters of the stratified flow. The determination of the affected pipes can be based on the international operational experience and on engineering consideration. The most affected pipes in PWRs are the pressurizer surge line, the injection pipe of the emergency core cooling systems and the feedwater injection pipe of the steam generators. CFD codes can provide an appropriate tool for the examination of the development and the breaking up of the stratification and the determination of the temperature distribution. However, the challenge of the uncertainty of the boundary conditions has to be faced because of the unknown flow circumstances. According to an extensive evaluation, performed in 1998 by the VEIKI, in the VVER-440/213 units of Paks NPP the most affected pipe is the pressurizer surge line [1]. To find out the possible thermal stratification in the surge line, a temperature monitoring system was installed on the YP20 leg of the surge line of the Unit 1 of the Paks NPP in 2000. The measurements showed that during the heat-up period there is a thermal stratification almost all time in the surge line [2]. The maximum temperature differences reach 140 K (140 deg. C). The surge line has been modeled with the CFD code CFX-5.7. The performed transient simulations confirmed the existence of a thermal stratification in the surge line, but showed permanent recirculation of colder coolant in the lower layer, caused by the asymmetric arrangement of the surge line legs and the asymmetric connection of the two legs to the main loop. In this paper, the surge line model and the results of the transient simulations are presented. The CFD model of the injection pipe of the high

  6. Modifications and Modelling of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    NASA Technical Reports Server (NTRS)

    Garber, Ann E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of the Single Flow Cell Test Apparatus (SFCTA) in the test section. Performance of the ALIP, provided by Idaho National Laboratory (INL), will be evaluated when testing resumes. The SFCTA, which will be tested simultaneously, will provide data on alkali metal flow behavior through the simulated core channels and assist in the development of a second generation thermal simulator. Additionally, data from the first round of testing has been used to refine the working system model, developed using the Generalized Fluid System Simulation Program (GFSSP). This paper covers the modifications of the FSP-PTC and the updated GFSSP system model.

  7. Intra-areal and corticocortical circuits arising in the dysgranular zone of rat primary somatosensory cortex that processes deep somatic input.

    PubMed

    Kim, Uhnoh; Lee, Taehee

    2013-08-01

    Somesthesis-guided exploration of the external world requires cortical processing of both cutaneous and proprioceptive information and their integration into motor commands to guide further haptic movement. In the past, attention has been given mostly to the cortical circuits processing cutaneous information for somatic motor integration. By comparison, little has been examined about how cortical circuits are organized for higher order proprioceptive processing. Using the rat cortex as a model, we characterized the intrinsic and corticocortical circuits arising in the major proprioceptive region of the primary somatosensory cortex (SI) that is conventionally referred to as the dysgranular zone (DSZ). We made small injections of biotinylated dextran amine (BDA) as an anterograde tracer in various parts of the DSZ, revealing three distinct principles of its cortical circuit organization. First, its intrinsic circuits extend mainly along the major axis of DSZ to organize multiple patches of interconnections. Second, the central and peripheral regions of DSZ produce differential patterns of intra-areal and corticocortical circuits. Third, the projection fields of DSZ encompass only selective regions of the second somatic (SII), posterior parietal (PPC), and primary motor (MI) cortices. These projection fields are at least partially separated from those of SI cutaneous areas. We hypothesize, based on these observations, that the cortical circuits of DSZ facilitate a modular integration of proprioceptive information along its major axis and disseminate this information to only selective parts of higher order somatic and MI cortices in parallel with cutaneous information.

  8. Inflammatory Cell Distribution in Primary Merkel Cell Carcinoma

    PubMed Central

    Wheat, Rachel; Roberts, Claudia; Waterboer, Tim; Steele, Jane; Marsden, Jerry; Steven, Neil M.; Blackbourn, David J.

    2014-01-01

    Merkel cell carcinoma (MCC) is an aggressive poorly differentiated neuroendocrine cutaneous carcinoma associated with older age, immunodeficiency and Merkel cell polyomavirus (MCPyV) integrated within malignant cells. The presence of intra-tumoural CD8+ lymphocytes reportedly predicts better MCC-specific survival. In this study, the distribution of inflammatory cells and properties of CD8+ T lymphocytes within 20 primary MCC specimens were characterised using immunohistochemistry and multicolour immunofluorescent staining coupled to confocal microscopy. CD8+ cells and CD68+ macrophages were identified in 19/20 primary MCC. CD20+ B cells were present in 5/10, CD4+ cells in 10/10 and FoxP3+ cells in 7/10 specimens. Only two specimens had almost no inflammatory cells. Within specimens, inflammatory cells followed the same patchy distribution, focused at the edge of sheets and nodules and, in some cases, more intense in trabecular areas. CD8+ cells were outside vessels on the edge of tumour. Those few within malignant sheets typically lined up in fine septa not contacting MCC cells expressing MCPyV large T antigen. The homeostatic chemokine CXCL12 was expressed outside malignant nodules whereas its receptor CXCR4 was identified within tumour but not on CD8+ cells. CD8+ cells lacked CXCR3 and granzyme B expression irrespective of location within stroma versus malignant nodules or of the intensity of the intra-tumoural infiltrate. In summary, diverse inflammatory cells were organised around the margin of malignant deposits suggesting response to aberrant signaling, but were unable to penetrate the tumour microenvironment itself to enable an immune response against malignant cells or their polyomavirus. PMID:24961933

  9. Effects of PbO on the oxide films of incoloy 800HT in simulated primary circuit of PWR

    NASA Astrophysics Data System (ADS)

    Tan, Yu; Yang, Junhan; Wang, Wanwan; Shi, Rongxue; Liang, Kexin; Zhang, Shenghan

    2016-05-01

    Effects of trace PbO on oxide films of Incoloy 800HT were investigated in simulated primary circuit water chemistry of PWR, also with proper Co addition. The trace PbO addition in high temperature water blocked the protective spinel oxides formation of the oxide films of Incoloy 800HT. XPS results indicated that the lead, added as PbO into the high temperature water, shows not only +2 valance but also +4 and 0 valances in the oxide film of 800HT co-operated with Fe, Cr and Ni to form oxides films. Potentiodynamic polarization results indicated that as PbO concentration increased, the current densities of the less protective oxide films of Incoloy 800HT decreased in a buffer solution tested at room temperature. The capacitance results indicated that the donor densities of oxidation film of Incoloy 800HT decreased as trace PbO addition into the high temperature water.

  10. 50-Gb/s NRZ and RZ Modulator Driver ICs Based on Functional Distributed Circuits

    NASA Astrophysics Data System (ADS)

    Suzuki, Yasuyuki; Mamada, Masayuki

    We have developed two modulator driver ICs that are based on the functional distributed circuit (FDC) topology for over 40-Gb/s optical transmission systems using InP HBT technology. The FDC topology enables both a wide bandwidth amplifier and high-speed digital functions. The none-return-to-zero (NRZ) driver IC, which is integrated with a D-type flip-flop, exhibits 2.6-Vp-p (differential output: 5.2Vp-p) output-voltage swings with a high signal quality at 43 and 50Gb/s. The return-to-zero (RZ) driver IC, which is integrated with a NRZ to RZ converter, produces 2.4-Vp-p (differential output: 4.8Vp-p) output-voltage swings and excellent eye openings at 43 and 50Gb/s. Furthermore, we conducted electro-optical modulation experiments using the developed modulator driver ICs and a dual drive LiNbO3 Mach-Zehnder modulator. We were able to obtain NRZ and RZ clear optical eye openings with low jitters and sufficient extinction ratios of more than 12dB, at 43 and 50Gb/s. These results indicate that the FDC has the potential to achieve a large output voltage and create high-speed functional ICs for over-40-Gb/s transmission systems.

  11. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    H.J. Walqui; T.C. Eisele; S.K. Kawatra

    2004-07-01

    The goal of this project is to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. The goal is to save energy by reducing the amount of material that is ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that are too fine to be useful. This is being accomplished by mathematical modeling of the grinding circuits to determine how to correct this problem. It has been determined that, for mixtures of approximately equal quantities of high-density minerals (such as iron oxides) and low-density minerals (such as quartz), existing hydrocyclone models fail to accurately predict the hydrocyclone behavior. Since the hydrocyclone is the key unit controlling the particle size, an accurate model of these units is required and is being fully developed. Experimental work has demonstrated that the previous models are inaccurate due to incorrect assumptions concerning the change in hydrocyclone cut size as a function of changing particle density.

  12. OPTIMIZATION OF COMMINUTION CIRCUIT THROUGHPUT AND PRODUCT SIZE DISTRIBUTION BY SIMULATION AND CONTROL

    SciTech Connect

    S.K. Kawatra; T.C. Eisele; H.J. Walqui

    2001-12-01

    The goal of this project is to improve the energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process are being used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced can be minimized. This will save energy by reducing the amount of material that is ground to below the target size, and will also reduce the quantity of material wasted as slimes that are too fine to be useful. This will be accomplished by: (1) modeling alternative circuit arrangements to determine methods for minimizing overgrinding, and (2) determining whether new technologies, such as high-pressure roll crushing, can be used to alter particle breakage behavior to minimize fines production. In the first quarter of this project, work was completed on a basic comminution model that will be used to carry out the subsequent project tasks. This phase of the work was supported by the Electric Power Research Institute, as their cost-share contribution to the project. The model has been implemented as an Excel spreadsheet, which has the advantage of being a very portable format that can be made widely available to the industry once the project is completed.

  13. Life cycle assessment of overhead and underground primary power distribution.

    PubMed

    Bumby, Sarah; Druzhinina, Ekaterina; Feraldi, Rebe; Werthmann, Danae; Geyer, Roland; Sahl, Jack

    2010-07-15

    Electrical power can be distributed in overhead or underground systems, both of which generate a variety of environmental impacts at all stages of their life cycles. While there is considerable literature discussing the trade-offs between both systems in terms of aesthetics, safety, cost, and reliability, environmental assessments are relatively rare and limited to power cable production and end-of-life management. This paper assesses environmental impacts from overhead and underground medium voltage power distribution systems as they are currently built and managed by Southern California Edison (SCE). It uses process-based life cycle assessment (LCA) according to ISO 14044 (2006) and SCE-specific primary data to the extent possible. Potential environmental impacts have been calculated using a wide range of midpoint indicators, and robustness of the results has been investigated through sensitivity analysis of the most uncertain and potentially significant parameters. The studied underground system has higher environmental impacts in all indicators and for all parameter values, mostly due to its higher material intensity. For both systems and all indicators the majority of impact occurs during cable production. Promising strategies for impact reduction are thus cable failure rate reduction for overhead and cable lifetime extension for underground systems.

  14. Exploitation of parallelism and ultraspeed integrated circuits in the next generation of distributed super signal processors

    SciTech Connect

    Gilbert, B.K.; Naused, B.A.; Hartley, S.M.; Vannurden, W.K.; Deming, R.

    1983-10-01

    The emerging application of gallium arsenide digital integrated circuits to signal processing problems will require the development of architectures tuned to its special characteristics. Chip design methods may be similar to those used for silicon very high-speed integrated circuit (VHSIC) components, but system design constraints will be unique to GAAS. 8 references.

  15. Low Insertion HVDC Circuit Breaker: Magnetically Pulsed Hybrid Breaker for HVDC Power Distribution Protection

    SciTech Connect

    2012-01-09

    GENI Project: General Atomics is developing a direct current (DC) circuit breaker that could protect the grid from faults 100 times faster than its alternating current (AC) counterparts. Circuit breakers are critical elements in any electrical system. At the grid level, their main function is to isolate parts of the grid where a fault has occurred—such as a downed power line or a transformer explosion—from the rest of the system. DC circuit breakers must interrupt the system during a fault much faster than AC circuit breakers to prevent possible damage to cables, converters and other grid-level components. General Atomics’ high-voltage DC circuit breaker would react in less than 1/1,000th of a second to interrupt current during a fault, preventing potential hazards to people and equipment.

  16. Quantum circuit for the proof of the security of quantum key distribution without encryption of error syndrome and noisy processing

    NASA Astrophysics Data System (ADS)

    Tamaki, Kiyoshi; Kato, Go

    2010-02-01

    One of the simplest security proofs of quantum key distribution is based on the so-called complementarity scenario, which involves the complementarity control of an actual protocol and a virtual protocol [M. Koashi, e-print arXiv:0704.3661 (2007)]. The existing virtual protocol has a limitation in classical postprocessing, i.e., the syndrome for the error-correction step has to be encrypted. In this paper, we remove this limitation by constructing a quantum circuit for the virtual protocol. Moreover, our circuit with a shield system gives an intuitive proof of why adding noise to the sifted key increases the bit error rate threshold in the general case in which one of the parties does not possess a qubit. Thus, our circuit bridges the simple proof and the use of wider classes of classical postprocessing.

  17. Quantum circuit for the proof of the security of quantum key distribution without encryption of error syndrome and noisy processing

    SciTech Connect

    Tamaki, Kiyoshi; Kato, Go

    2010-02-15

    One of the simplest security proofs of quantum key distribution is based on the so-called complementarity scenario, which involves the complementarity control of an actual protocol and a virtual protocol [M. Koashi, e-print arXiv:0704.3661 (2007)]. The existing virtual protocol has a limitation in classical postprocessing, i.e., the syndrome for the error-correction step has to be encrypted. In this paper, we remove this limitation by constructing a quantum circuit for the virtual protocol. Moreover, our circuit with a shield system gives an intuitive proof of why adding noise to the sifted key increases the bit error rate threshold in the general case in which one of the parties does not possess a qubit. Thus, our circuit bridges the simple proof and the use of wider classes of classical postprocessing.

  18. Distribution of lifespan gain from primary prevention intervention

    PubMed Central

    Finegold, Judith A; Shun-Shin, Matthew J; Cole, Graham D; Zaman, Saman; Maznyczka, Annette; Zaman, Sameer; Al-Lamee, Rasha; Ye, Siqin; Francis, Darrel P

    2016-01-01

    Objective When advising patients about possible initiation of primary prevention treatment, clinicians currently do not have information on expected impact on lifespan, nor how much this increment differs between individuals. Methods First, UK cardiovascular and non-cardiovascular mortality data were used to calculate the mean lifespan gain from an intervention (such as a statin) that reduces cardiovascular mortality by 30%. Second, a new method was developed to calculate the probability distribution of lifespan gain. Third, we performed a survey in three UK cities on 11 days between May–June 2014 involving 396 participants (mean age 40 years, 55% male) to assess how individuals evaluate potential benefit from primary prevention therapies. Results Among numerous identical patients, the lifespan gain, from an intervention that reduces cardiovascular mortality by 30%, is concentrated within an unpredictable minority. For example, men aged 50 years with national average cardiovascular risk have mean lifespan gain of 7 months. However, 93% of these identical individuals gain no lifespan, while the remaining 7% gain a mean of 99 months. Many survey respondents preferred a chance of large lifespan gain to the equivalent life expectancy gain given as certainty. Indeed, 33% preferred a 2% probability of 10 years to fivefold more gain, expressed as certainty of 1 year. Conclusions People who gain lifespan from preventative therapy gain far more than the average for their risk stratum, even if perfectly defined. This may be important in patient decision-making. Looking beyond mortality reduction alone from preventative therapy, the benefits are likely to be even larger. PMID:27042321

  19. Mechanisms of coordination in distributed neural circuits: decoding and integration of coordinating information.

    PubMed

    Smarandache-Wellmann, Carmen; Weller, Cynthia; Mulloney, Brian

    2014-01-15

    We describe the synaptic connections through which information required to coordinate limb movements reaches the modular microcircuits that control individual limbs on different abdominal segments of the crayfish, Pacifastacus leniusculus. In each segmental ganglion, a local commissural interneuron, ComInt 1, integrates information about other limbs and transmits it to one microcircuit. Five types of nonspiking local interneurons are components of each microcircuit's pattern-generating kernel (Smarandache-Wellmann et al., 2013). We demonstrate here, using paired microelectrode recordings, that the pathway through which information reaches this kernel is an electrical synapse between ComInt 1 and one of these five types, an IRSh interneuron. Using single-electrode voltage clamp, we show that brief changes of ComInt 1's membrane potential affect the timing of its microcircuit's motor output. Changing ComInt 1's membrane potential also changes the phase, duration, and strengths of bursts of spikes in its microcircuit's motor neurons and corresponding changes in its efferent coordinating neurons that project to other ganglia. These effects on coordinating neurons cause changes in the phases of motor output from other microcircuits in those distant ganglia. ComInt 1s function as hub neurons in the intersegmental circuit that synchronizes distributed microcircuits. The synapse between each ComInt 1 and its microcircuit's IRSh neuron completes a five synapse pathway in which analog information is encoded as a digital signal by efference-copy neurons and decoded from digital to analog form by ComInt 1. The synaptic organization of this pathway provides a cellular explanation of this nervous system's key dynamic properties.

  20. Mechanisms of Coordination in Distributed Neural Circuits: Decoding and Integration of Coordinating Information

    PubMed Central

    Smarandache-Wellmann, Carmen; Weller, Cynthia

    2014-01-01

    We describe the synaptic connections through which information required to coordinate limb movements reaches the modular microcircuits that control individual limbs on different abdominal segments of the crayfish, Pacifastacus leniusculus. In each segmental ganglion, a local commissural interneuron, ComInt 1, integrates information about other limbs and transmits it to one microcircuit. Five types of nonspiking local interneurons are components of each microcircuit's pattern-generating kernel (Smarandache-Wellmann et al., 2013). We demonstrate here, using paired microelectrode recordings, that the pathway through which information reaches this kernel is an electrical synapse between ComInt 1 and one of these five types, an IRSh interneuron. Using single-electrode voltage clamp, we show that brief changes of ComInt 1's membrane potential affect the timing of its microcircuit's motor output. Changing ComInt 1's membrane potential also changes the phase, duration, and strengths of bursts of spikes in its microcircuit's motor neurons and corresponding changes in its efferent coordinating neurons that project to other ganglia. These effects on coordinating neurons cause changes in the phases of motor output from other microcircuits in those distant ganglia. ComInt 1s function as hub neurons in the intersegmental circuit that synchronizes distributed microcircuits. The synapse between each ComInt 1 and its microcircuit's IRSh neuron completes a five synapse pathway in which analog information is encoded as a digital signal by efference-copy neurons and decoded from digital to analog form by ComInt 1. The synaptic organization of this pathway provides a cellular explanation of this nervous system's key dynamic properties. PMID:24431438

  1. Flotation rate and residence time distribution in continuous coal froth flotation circuits and an evaluation of reagents and circuit variations for pyritic sulfur removal

    SciTech Connect

    Arnold, B.J.

    1989-01-01

    This thesis gives the results of research conducted on several aspects of coal froth flotation. The effect of operating variables on the residence time distribution in coal froth flotation cells is discussed, and a model of the residence time distribution is presented for use with flotation rate models in scaling up from laboratory to plant scale. Flotation rate models are also investigated in detail for continuous coal froth flotation circuits. Changes in operating variables were found to affect the mean residence time in cells, but they did not have much effect on the mixing behavior. The use of a time lag was found to be an important part of rate models for continuous froth flotation cells. An important aspect of the use of such rate and residence time equations is their application to the flotation of gangue constituents, which often enter the froth by water carry-over in addition to natural flotation or flotation as slime coatings. As such, water carry-over is also investigated in this thesis for the laboratory and the plant and for both ash-forming minerals and pyrite. Maintaining a constant froth factor, the percentage of froth above the weir, in both laboratory and plant tests is believed to be a critical factor in predicting plant results using a kinetic factor ratio documented in the literature. Removing the pyrite and ash-forming minerals from coal that may be recovered by the water carry-over or other mechanisms is an important goal in coal froth flotation. This thesis also contains the results of tests with pyrite depressants and circuit variations for removal of pyritic sulfur.

  2. The primary circuit materials properties results analysis performed on archive material used in NPP V-1 and Kola NPP Units 1 and 2

    SciTech Connect

    Kupca, L.; Beno, P.

    1997-04-01

    A very brief summary is provided of a primary circuit piping material properties analysis. The analysis was performed for the Bohunice V-1 reactor and the Kola-1 and -2 reactors. Assessment was performed on Bohunice V-1 archive materials and primary piping material cut from the Kola units after 100,000 hours of operation. Main research program tasks included analysis of mechanical properties, corrosion stability, and microstructural properties. Analysis results are not provided.

  3. Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia

    PubMed Central

    Urrios, Arturo; de Nadal, Eulàlia; Solé, Ricard; Posas, Francesc

    2016-01-01

    Engineered synthetic biological devices have been designed to perform a variety of functions from sensing molecules and bioremediation to energy production and biomedicine. Notwithstanding, a major limitation of in vivo circuit implementation is the constraint associated to the use of standard methodologies for circuit design. Thus, future success of these devices depends on obtaining circuits with scalable complexity and reusable parts. Here we show how to build complex computational devices using multicellular consortia and space as key computational elements. This spatial modular design grants scalability since its general architecture is independent of the circuit’s complexity, minimizes wiring requirements and allows component reusability with minimal genetic engineering. The potential use of this approach is demonstrated by implementation of complex logical functions with up to six inputs, thus demonstrating the scalability and flexibility of this method. The potential implications of our results are outlined. PMID:26829588

  4. Subject Leadership in Primary Schools--Towards Distributed Practice

    ERIC Educational Resources Information Center

    Hammersley-Fletcher, Linda

    2004-01-01

    This paper is based on findings from the authors' PhD thesis looking at the role of Subject Leadership in primary schools. The study reports data collected from 20 subject leaders in 10 schools within 2 Local Education Authorities and sets the role of the subject leader within the context of a primary school, highlighting the varied complexities…

  5. Conditioning of pretreated LLW generated by the decontamination of VVR-S nuclear research reactor primary circuit

    SciTech Connect

    Nicu, Mihaela I.; Ionascu, Laura A.; Dragolici, Felicia N.; Turcanu, Corneliu N.; Rotarescu, Gheorghe Gh.; Dogaru, Gheorghe C.

    2013-07-01

    Concentration of complexing acids solutions (oxalic acid, tartaric acid and citric acid) used in radioactive decontamination by chemical method affects both the mechanical stability and the chemical stability of cement matrix. The paper presents the works performed related to the chemical pretreatment of these organic acids solutions using as neutralizing agent Ca(OH){sub 2}. In this way it was possible to increase the concentration of organic acids solutions used and the soluble complex radionuclides passing in chemical precipitates, these affecting in a smaller manner the mechanical stability of the cement matrix. The chemical pretreatment the effluents improve the precipitation and conditioning performances by cementation. Were prepared compositions with complexing agents and compositions for oxidative degradation tests to simulate the concentrations of secondary radioactive waste obtained from the primary circuit decontamination of the VVR-S research reactor. It has been studied the influence of chemical pretreatment of complexing acids solutions of different concentrations on the setting time. Also it was determined the compressive strength of mortar samples in which were embedded these solutions of chemically pretreated organic acids. The results shown that an optimum cement - solution ratio doesn't have a significant impact on the setting time or on the mechanical properties. (authors)

  6. Distribution of language-related Cntnap2 protein in neural circuits critical for vocal learning.

    PubMed

    Condro, Michael C; White, Stephanie A

    2014-01-01

    Variants of the contactin associated protein-like 2 (Cntnap2) gene are risk factors for language-related disorders including autism spectrum disorder, specific language impairment, and stuttering. Songbirds are useful models for study of human speech disorders due to their shared capacity for vocal learning, which relies on similar cortico-basal ganglia circuitry and genetic factors. Here we investigate Cntnap2 protein expression in the brain of the zebra finch, a songbird species in which males, but not females, learn their courtship songs. We hypothesize that Cntnap2 has overlapping functions in vocal learning species, and expect to find protein expression in song-related areas of the zebra finch brain. We further expect that the distribution of this membrane-bound protein may not completely mirror its mRNA distribution due to the distinct subcellular localization of the two molecular species. We find that Cntnap2 protein is enriched in several song control regions relative to surrounding tissues, particularly within the adult male, but not female, robust nucleus of the arcopallium (RA), a cortical song control region analogous to human layer 5 primary motor cortex. The onset of this sexually dimorphic expression coincides with the onset of sensorimotor learning in developing males. Enrichment in male RA appears due to expression in projection neurons within the nucleus, as well as to additional expression in nerve terminals of cortical projections to RA from the lateral magnocellular nucleus of the nidopallium. Cntnap2 protein expression in zebra finch brain supports the hypothesis that this molecule affects neural connectivity critical for vocal learning across taxonomic classes.

  7. Network model and short circuit program for the Kennedy Space Center electric power distribution system

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Assumptions made and techniques used in modeling the power network to the 480 volt level are discussed. Basic computational techniques used in the short circuit program are described along with a flow diagram of the program and operational procedures. Procedures for incorporating network changes are included in this user's manual.

  8. Commentary: improving the supply and distribution of primary care physicians.

    PubMed

    Dorsey, E Ray; Nicholson, Sean; Frist, William H

    2011-05-01

    The current medical education system and reimbursement policies in the United States have contributed to a maldistribution of physicians by specialty and geography. The causes of this maldistribution include financial barriers that prevent the individuals who would be the most likely to serve in primary care and underserved areas from entering the profession, large taxpayer subsidies to teaching hospitals that provide incentives to act in ways that are not in the best interest of society, and reimbursement policies that discourage physicians from providing primary care. The authors propose that the maldistribution of physicians can be addressed successfully by reducing the financial barriers to becoming a primary care physician, aligning subsidies with societal interests, and providing financial incentives that target primary care. They suggest that the Patient Protection and Affordable Care Act of 2010 takes steps in the right direction but that more financially prudent measures should be taken as politicians revisit health care reform with heightened financial scrutiny.

  9. Development of the Phase Synchronization Circuit for Wirelessly Distributed Digital Phased Array

    DTIC Science & Technology

    2009-09-01

    retrieved on August 2, 2009. [14] C. H. Tong, “System study and design of broad-band U-slot microstrip patch antennas for aperstuctures and...a wireless channel. Compared to conventional phased array systems, its advantages are adaptability, survivability and flexibility . Phase...more flexible and robust than the current circuit and thus more desirable for future applications of the WDDPA. 15. NUMBER OF PAGES 130 14

  10. Early Disruption of Extracellular Pleiotrophin Distribution Alters Cerebellar Neuronal Circuit Development and Function.

    PubMed

    Hamza, M M; Rey, S A; Hilber, P; Arabo, A; Collin, T; Vaudry, D; Burel, D

    2016-10-01

    The cerebellum is a structure of the central nervous system involved in balance, motor coordination, and voluntary movements. The elementary circuit implicated in the control of locomotion involves Purkinje cells, which receive excitatory inputs from parallel and climbing fibers, and are regulated by cerebellar interneurons. In mice as in human, the cerebellar cortex completes its development mainly after birth with the migration, differentiation, and synaptogenesis of granule cells. These cellular events are under the control of numerous extracellular matrix molecules including pleiotrophin (PTN). This cytokine has been shown to regulate the morphogenesis of Purkinje cells ex vivo and in vivo via its receptor PTPζ. Since Purkinje cells are the unique output of the cerebellar cortex, we explored the consequences of their PTN-induced atrophy on the function of the cerebellar neuronal circuit in mice. Behavioral experiments revealed that, despite a normal overall development, PTN-treated mice present a delay in the maturation of their flexion reflex. Moreover, patch clamp recording of Purkinje cells revealed a significant increase in the frequency of spontaneous excitatory postsynaptic currents in PTN-treated mice, associated with a decrease of climbing fiber innervations and an abnormal perisomatic localization of the parallel fiber contacts. At adulthood, PTN-treated mice exhibit coordination impairment on the rotarod test associated with an alteration of the synchronization gait. Altogether these histological, electrophysiological, and behavior data reveal that an early ECM disruption of PTN composition induces short- and long-term defaults in the establishment of proper functional cerebellar circuit.

  11. Long-tailed distribution of synaptic strength reveals origin and functional roles of ongoing fluctuation in cortical circuit

    NASA Astrophysics Data System (ADS)

    Teramae, Jun-nosuke

    2016-06-01

    Neurons in the cortical circuit continuous to generate irregular spike firing with extremely low firing rate (about 1-2 Hz) even when animals neither receive any external stimuli nor they do not show any significant motor movement. The ongoing activity is often called neuronal noise because measured spike trains are often highly irregular and also spike timings are highly asynchronous among neurons. Many experiments imply that neural networks themselves must generate the noisy activity as an intrinsic property of cortical circuit. However, how a network of neurons sustains the irregular spike firings with low firing rate remains unclear. Recently, by focusing on long-tailed distribution of amplitude of synaptic connections or EPSP (Excitatory Post-Synaptic Potential), we successfully revealed that due to coexistence of a few extremely strong synaptic connections and majority of weak synapses, nonlinear dynamics of population of spiking neurons can have a nontrivial stable state that corresponding to the intrinsic ongoing fluctuation of the cortical circuit. We also found that due to the fluctuation fidelity of spike transmission between neurons are optimized. Here, we report our recent findings of the ongoing fluctuation from viewpoints of mathematical and computational side.

  12. A novel approach to predict the pin load distribution of multiple bolt-jointed composite laminate based on the circuit model

    NASA Astrophysics Data System (ADS)

    Yang, Xiankun; Chen, Haoyuan; Cheng, Linan; Zheng, Xitao

    2011-11-01

    The circuit model was applied to predict the pin load distribution of composite multiple bolt-joint structure. The load, flexibility and deformation of the mechanics model were equivalent to the current, resistance and voltage of the circuit model, respectively. Based on the above assumption, it could be found that the Hooke's law and the deformation compatibility equation in the origin mechanics model transformed into the Ohm's law and the voltage balance equation in the new circuit model. This approach translated the complex model of composite multiple bolt-jointed into a simple circuit model which consisted of some series circuits and parallel circuits. The analysis of the new circuit model had formed n-1 independence voltage balance equations and a current balance equation, thus, the current and load of each bolt could be calculated. In the new model, power sources which were added as required in some branch circuits could also simulate the clearance or interference in the origin model. Compared with the result of the multiple bolt-joints composite laminate test, the new approach could make an excellent performance to estimate the load distribution.

  13. A novel approach to predict the pin load distribution of multiple bolt-jointed composite laminate based on the circuit model

    NASA Astrophysics Data System (ADS)

    Yang, Xiankun; Chen, Haoyuan; Cheng, Linan; Zheng, Xitao

    2012-04-01

    The circuit model was applied to predict the pin load distribution of composite multiple bolt-joint structure. The load, flexibility and deformation of the mechanics model were equivalent to the current, resistance and voltage of the circuit model, respectively. Based on the above assumption, it could be found that the Hooke's law and the deformation compatibility equation in the origin mechanics model transformed into the Ohm's law and the voltage balance equation in the new circuit model. This approach translated the complex model of composite multiple bolt-jointed into a simple circuit model which consisted of some series circuits and parallel circuits. The analysis of the new circuit model had formed n-1 independence voltage balance equations and a current balance equation, thus, the current and load of each bolt could be calculated. In the new model, power sources which were added as required in some branch circuits could also simulate the clearance or interference in the origin model. Compared with the result of the multiple bolt-joints composite laminate test, the new approach could make an excellent performance to estimate the load distribution.

  14. Distributed Circuit Plasticity: New Clues for the Cerebellar Mechanisms of Learning.

    PubMed

    D'Angelo, Egidio; Mapelli, Lisa; Casellato, Claudia; Garrido, Jesus A; Luque, Niceto; Monaco, Jessica; Prestori, Francesca; Pedrocchi, Alessandra; Ros, Eduardo

    2016-04-01

    The cerebellum is involved in learning and memory of sensory motor skills. However, the way this process takes place in local microcircuits is still unclear. The initial proposal, casted into the Motor Learning Theory, suggested that learning had to occur at the parallel fiber-Purkinje cell synapse under supervision of climbing fibers. However, the uniqueness of this mechanism has been questioned, and multiple forms of long-term plasticity have been revealed at various locations in the cerebellar circuit, including synapses and neurons in the granular layer, molecular layer and deep-cerebellar nuclei. At present, more than 15 forms of plasticity have been reported. There has been a long debate on which plasticity is more relevant to specific aspects of learning, but this question turned out to be hard to answer using physiological analysis alone. Recent experiments and models making use of closed-loop robotic simulations are revealing a radically new view: one single form of plasticity is insufficient, while altogether, the different forms of plasticity can explain the multiplicity of properties characterizing cerebellar learning. These include multi-rate acquisition and extinction, reversibility, self-scalability, and generalization. Moreover, when the circuit embeds multiple forms of plasticity, it can easily cope with multiple behaviors endowing therefore the cerebellum with the properties needed to operate as an effective generalized forward controller.

  15. The Challenges of Distributing Leadership in Irish Post-Primary Schools

    ERIC Educational Resources Information Center

    O'Donovan, Margaret

    2015-01-01

    This study explores the challenges and opportunities in relation to developing distributed leadership practice in Irish post-primary schools. It considers school leadership within the context of contemporary distributed leadership theory. Associated concepts such as distributed cognition and activity theory are used to frame the study. The study…

  16. Mitochondrial ion circuits.

    PubMed

    Nicholls, David G

    2010-01-01

    Proton circuits across the inner mitochondrial membrane link the primary energy generators, namely the complexes of the electron transport chain, to multiple energy utilizing processes, including the ATP synthase, inherent proton leak pathways, metabolite transport and linked circuits of sodium and calcium. These mitochondrial circuits can be monitored in both isolated preparations and intact cells and, for the primary proton circuit techniques, exist to follow both the proton current and proton electrochemical potential components of the circuit in parallel experiments, providing a quantitative means of assessing mitochondrial function and, equally importantly, dysfunction.

  17. Professional Learning for Distributed Leadership: Primary Headteachers' Perspectives

    ERIC Educational Resources Information Center

    Torrance, Deirdre

    2015-01-01

    This article draws from a small-scale study of headteachers motivated to positively impact on the quality of pupil experience by involving all staff in a distributed perspective on leadership. Each headteacher perceived leadership as involving learned processes requiring support and experience, expending considerable effort in providing a fertile…

  18. Physical Concepts and Modeling Procedures for Picosecond and Subpicosecond Distributed Circuits

    DTIC Science & Technology

    1991-06-01

    Sonnet Software (makers of em, an electromagnetic structure 3 simulator for arbitrary geometries.) Both versions of SPICE we have currently otter...of the diatomic lattice .................... 73 5.3 Radiation sources on the distributed doubler ................. 77 5.4 Layout of the distributed...upper branch is possible, as demonstrated by I 3 CHAPTER 5. DISTRIBUTED FREQUENCY MULTIPLICATION 73 I popm I I * 0 c k*1 (per section) Figure 5.2

  19. History of Physics as a Tool to Detect the Conceptual Difficulties Experienced by Students: The Case of Simple Electric Circuits in Primary Education

    NASA Astrophysics Data System (ADS)

    Leone, Matteo

    2014-04-01

    The present paper advocates the use of History of Science into the teaching of science in primary education through a case study in the field of electricity. In this study, which provides both historical and experimental evidence, a number of conceptual difficulties faced by early nineteenth century physicists are shown to be a useful tool to detect 5th grade pupils' conceptions about the simple electric circuits. This result was obtained through the administration of schematics showing circuital situation inspired to early 1800s experiments on the effects of electric current on water electrolysis and on the behaviour of magnetic compasses. It is also shown that the detecting of pupils' alternative ideas about electric current in a circuit is highly dependent on the survey methodology (open ended questions and drawings, multiple-choice item, connecting card work, and history of science tasks were considered in this study) and that the so-called "unipolar model" of electric circuit is more pervasive than previously acknowledged. Finally, a highly significant hybrid model of electric current is identified.

  20. 17 CFR 285.3 - Reports with respect to proposed distribution of primary obligations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SECURITIES AND EXCHANGE COMMISSION (CONTINUED) RULES AND REGULATIONS PURSUANT TO SECTION 15(a) OF THE BRETTON WOODS AGREEMENTS ACT § 285.3 Reports with respect to proposed distribution of primary obligations....

  1. 17 CFR 285.3 - Reports with respect to proposed distribution of primary obligations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... SECURITIES AND EXCHANGE COMMISSION (CONTINUED) RULES AND REGULATIONS PURSUANT TO SECTION 15(a) OF THE BRETTON WOODS AGREEMENTS ACT § 285.3 Reports with respect to proposed distribution of primary obligations....

  2. Sparse Distributed Representation of Odors in a Large-scale Olfactory Bulb Circuit

    PubMed Central

    Yu, Yuguo; McTavish, Thomas S.; Hines, Michael L.; Shepherd, Gordon M.; Valenti, Cesare; Migliore, Michele

    2013-01-01

    In the olfactory bulb, lateral inhibition mediated by granule cells has been suggested to modulate the timing of mitral cell firing, thereby shaping the representation of input odorants. Current experimental techniques, however, do not enable a clear study of how the mitral-granule cell network sculpts odor inputs to represent odor information spatially and temporally. To address this critical step in the neural basis of odor recognition, we built a biophysical network model of mitral and granule cells, corresponding to 1/100th of the real system in the rat, and used direct experimental imaging data of glomeruli activated by various odors. The model allows the systematic investigation and generation of testable hypotheses of the functional mechanisms underlying odor representation in the olfactory bulb circuit. Specifically, we demonstrate that lateral inhibition emerges within the olfactory bulb network through recurrent dendrodendritic synapses when constrained by a range of balanced excitatory and inhibitory conductances. We find that the spatio-temporal dynamics of lateral inhibition plays a critical role in building the glomerular-related cell clusters observed in experiments, through the modulation of synaptic weights during odor training. Lateral inhibition also mediates the development of sparse and synchronized spiking patterns of mitral cells related to odor inputs within the network, with the frequency of these synchronized spiking patterns also modulated by the sniff cycle. PMID:23555237

  3. Preparation of Power Distribution System for High Penetration of Renewable Energy Part I. Dynamic Voltage Restorer for Voltage Regulation Pat II. Distribution Circuit Modeling and Validation

    NASA Astrophysics Data System (ADS)

    Khoshkbar Sadigh, Arash

    by simulation and experimental tests under various conditions considering all possible cases such as different amounts of voltage sag depth (VSD), different amounts of point-on-wave (POW) at which voltage sag occurs, harmonic distortion, line frequency variation, and phase jump (PJ). Furthermore, the ripple amount of fundamental voltage amplitude calculated by the proposed method and its error is analyzed considering the line frequency variation together with harmonic distortion. The best and worst detection time of proposed method were measured 1ms and 8.8ms, respectively. Finally, the proposed method has been compared with other voltage sag detection methods available in literature. Part 2: Power System Modeling for Renewable Energy Integration: As power distribution systems are evolving into more complex networks, electrical engineers have to rely on software tools to perform circuit analysis. There are dozens of powerful software tools available in the market to perform the power system studies. Although their main functions are similar, there are differences in features and formatting structures to suit specific applications. This creates challenges for transferring power system circuit models data (PSCMD) between different software and rebuilding the same circuit in the second software environment. The objective of this part of thesis is to develop a Unified Platform (UP) to facilitate transferring PSCMD among different software packages and relieve the challenges of the circuit model conversion process. UP uses a commonly available spreadsheet file with a defined format, for any home software to write data to and for any destination software to read data from, via a script-based application called PSCMD transfer application. The main considerations in developing the UP are to minimize manual intervention and import a one-line diagram into the destination software or export it from the source software, with all details to allow load flow, short circuit and

  4. Conceptions of Pupils of the Primary on the Topic of an Electric Circuit in Three Countries (Canada, France and Morocco)

    ERIC Educational Resources Information Center

    Métioui, Abdeljalil; MacWillie, Mireille Baulu; Trudel, Louis

    2016-01-01

    Qualitative research conducted with 237 pupils from Canada, France, and Morocco, between 10 and 12 years of age, on the setting and functioning of simple electric circuits, demonstrates that similar explanatory systems of the students. For this, we had given them a paper and pencil questionnaire of a sixty minutes duration. The first question was…

  5. Electrical Circuit Simulation Code

    SciTech Connect

    Wix, Steven D.; Waters, Arlon J.; Shirley, David

    2001-08-09

    Massively-Parallel Electrical Circuit Simulation Code. CHILESPICE is a massively-arallel distributed-memory electrical circuit simulation tool that contains many enhanced radiation, time-based, and thermal features and models. Large scale electronic circuit simulation. Shared memory, parallel processing, enhance convergence. Sandia specific device models.

  6. Theoretical and Experimental Study of the Primary Current Distribution in Parallel-Plate Electrochemical Reactors

    ERIC Educational Resources Information Center

    Vazquez Aranda, Armando I.; Henquin, Eduardo R.; Torres, Israel Rodriguez; Bisang, Jose M.

    2012-01-01

    A laboratory experiment is described to determine the primary current distribution in parallel-plate electrochemical reactors. The electrolyte is simulated by conductive paper and the electrodes are segmented to measure the current distribution. Experiments are reported with the electrolyte confined to the interelectrode gap, where the current…

  7. Primary-secondary pumping conversion: Retrofit of an existing campus chilled water distribution system

    SciTech Connect

    Sczomak, D.P.; Nguyen, P.N.

    1996-08-01

    The chilled water distribution system within an existing 8,300 ton (29,200 kW) capacity regional chilled water plant at Michigan State University (MSU) is being converted from a primary pumping arrangement to a primary-secondary arrangement. The plant presently provides chilled water for air conditioning to twelve remote buildings. In the future, MSU plans to increase the plant`s capacity to 10,800 tons (38,000 kW) in order to serve seven more buildings. The addition of buildings to the distribution system has caused the existing primary pumps to be incapable of producing enough pressure to offset system losses at design flow rates. The existing system has become unable to concurrently provide adequate flow, design supply water temperature and efficient chiller operation due to the distribution system deficiencies. The primary-secondary pumping conversion will include modifications to the distribution piping, the addition of five variable speed secondary pumps, additions and modifications to the control systems, the trimming of impellers on six of the existing primary pumps and replacement of two primary pumps. The campus central control system will be utilized to provide automatic chiller staging, interface with the packaged secondary pump control systems, and control of the building interconnections. The total construction cost is approximately $1,400,000 and is scheduled for completion prior to the 1996 cooling season. Provisions have been made for two additional secondary pumps to accommodate the connection of additional buildings to the distribution system in the future.

  8. High-Speed Large-Alphabet Quantum Key Distribution Using Photonic Integrated Circuits

    DTIC Science & Technology

    2014-01-28

    interaction in graphene coupled to a photonic crystal nanocavity. Nano Letters, 12(11):5626-5631, 2012. 7. High-dimensional quantum key distribution...Chip- integrated ultrafast graphene photodetector with high responsivity, , Nature Photonics (03 2013) Tian Zhong, Franco N. C. Wong. Nonlocal... GRAPHENE PHOTONICS FOR RESONATOR-ENHANCED ELECTRO-OPTIC DEVICES AND ALL-OPTICAL INTERACTIONS SYSTEMS AND METHODS FOR COUPLING ELECTROMAGNETIC

  9. Axonal varicosity distributions along parallel fibers: a new angle on a cerebellar circuit.

    PubMed

    Shepherd, Gordon M G; Raastad, Morten

    2003-01-01

    Presynaptic terminals occur along unmyelinated axons in specialized compartments called axonal varicosities or synaptic boutons. Since the first descriptions of varicose axons by Cajal and others, the spatial organization of varicosities along axons has attracted the attention of neuroscientists. Quantitative light- and electron-microscopic analyses of varicosity spacing in the cerebellum and elsewhere have recently provided a clearer picture of this organization, and theoretical analyses now incorporate varicosity spacing as an essential parameter in structural models of neural connectivity. Here we review the salient features of varicosity spacing, with emphasis on cerebellar parallel fibers as a model system. Measured globally across the entire approximately 5 mm lengths of parallel fibers, the overall mean spacing of varicosities is 5.2 microm. Measured locally, however, mean spacing follows a proximodistal gradient, increasing with distance from the point of bifurcation from the ascending axon. Measured at the level of individual varicosities, parallel fiber varicosity distributions follow a distinct pattern characterized by a fixed relationship between the spacing variability and mean. This pattern equally describes varicosity distributions in a number of other brain regions, and therefore appears to constitute a general scaling relationship for excitatory varicose axons. We further discuss evidence for common principles underlying the placement of both varicosities and synapses along axons.

  10. Enabling functional neural circuit simulations with distributed computing of neuromodulated plasticity.

    PubMed

    Potjans, Wiebke; Morrison, Abigail; Diesmann, Markus

    2010-01-01

    A major puzzle in the field of computational neuroscience is how to relate system-level learning in higher organisms to synaptic plasticity. Recently, plasticity rules depending not only on pre- and post-synaptic activity but also on a third, non-local neuromodulatory signal have emerged as key candidates to bridge the gap between the macroscopic and the microscopic level of learning. Crucial insights into this topic are expected to be gained from simulations of neural systems, as these allow the simultaneous study of the multiple spatial and temporal scales that are involved in the problem. In particular, synaptic plasticity can be studied during the whole learning process, i.e., on a time scale of minutes to hours and across multiple brain areas. Implementing neuromodulated plasticity in large-scale network simulations where the neuromodulatory signal is dynamically generated by the network itself is challenging, because the network structure is commonly defined purely by the connectivity graph without explicit reference to the embedding of the nodes in physical space. Furthermore, the simulation of networks with realistic connectivity entails the use of distributed computing. A neuromodulated synapse must therefore be informed in an efficient way about the neuromodulatory signal, which is typically generated by a population of neurons located on different machines than either the pre- or post-synaptic neuron. Here, we develop a general framework to solve the problem of implementing neuromodulated plasticity in a time-driven distributed simulation, without reference to a particular implementation language, neuromodulator, or neuromodulated plasticity mechanism. We implement our framework in the simulator NEST and demonstrate excellent scaling up to 1024 processors for simulations of a recurrent network incorporating neuromodulated spike-timing dependent plasticity.

  11. Approximate Calculation of Voltage in Three-Phase Primary Distribution Feeder

    NASA Astrophysics Data System (ADS)

    Iioka, Daisuke; Iwata, Kubou; Kondo, Hisashi; Sakaguchi, Takuma; Shigetou, Takaya; Matsumura, Toshiro

    An approximate method to calculate voltage in three-phase primary distribution feeder has been proposed. Generally, nonlinear simultaneous equations have been solved to calculate the voltage in power system since the dependence of electrical equipment on voltage is represented by exponential model such as constant power load, constant current load and constant impedance load. The nonlinear simultaneous equations were transformed to linear simultaneous equations by the proposed method. As a result, the proposed method can calculate the voltage without convergence calculations. It was found that the approximate value of voltage in the three-phase primary distribution feeder is in good agreement with the exact value.

  12. A Power Hardware-in-the-Loop Platform with Remote Distribution Circuit Cosimulation

    SciTech Connect

    Palmintier, Bryan; Lundstrom, Blake; Chakraborty, Sudipta; Williams, Tess L.; Schneider, Kevin P.; Chassin, David P.

    2015-04-01

    This paper demonstrates the use of a novel cosimulation architecture that integrates hardware testing using Power Hardware-in-the-Loop (PHIL) with larger-scale electric grid models using off-the-shelf, non-PHIL software tools. This architecture enables utilities to study the impacts of emerging energy technologies on their system and manufacturers to explore the interactions of new devices with existing and emerging devices on the power system, both without the need to convert existing grid models to a new platform or to conduct in-field trials. The paper describes an implementation of this architecture for testing two residential-scale advanced solar inverters at separate points of common coupling. The same hardware setup is tested with two different distribution feeders (IEEE 123 and 8500 node test systems) modeled using GridLAB-D. In addition to simplifying testing with multiple feeders, the architecture demonstrates additional flexibility with hardware testing in one location linked via the Internet to software modeling in a remote location. In testing, inverter current, real and reactive power, and PCC voltage are well captured by the co-simulation platform. Testing of the inverter advanced control features is currently somewhat limited by the software model time step (1 sec) and tested communication latency (24 msec). Overshoot induced oscillations are observed with volt/VAR control delays of 0 and 1.5 sec, while 3.4 sec and 5.5 sec delays produced little or no oscillation. These limitations could be overcome using faster modeling and communication within the same co-simulation architecture.

  13. Change in Excitability of Corticospinal Pathway and GABA-Mediated Inhibitory Circuits of Primary Motor Cortex Induced by Contraction of Adjacent Hand Muscle.

    PubMed

    Jono, Yasutomo; Iwata, Yasuyuki; Mizusawa, Hiroki; Hiraoka, Koichi

    2016-11-01

    The present study examined whether the excitability of the corticospinal pathway and the GABA-mediated inhibitory circuits of the primary motor cortex that project onto the corticospinal neurons in the tonically contracting hand muscle are changed by tonic contraction of the adjacent hand muscle. The motor evoked potential (MEP) and cortical silent period (CSP) in the tonically contracting hand muscle were obtained while the adjacent hand muscle was either tonically contracting or at rest. The MEP and CSP of the first dorsal interosseous (FDI) muscle elicited across the scalp sites where the MEP is predominantly elicited in the FDI muscle were decreased by tonic contraction of the abductor digiti minimi (ADM) muscle. The centers of the area of the MEP and the duration of the CSP in the FDI muscle elicited across the sites where the MEP is predominantly elicited in the FDI muscle were lateral to those in the FDI muscle elicited across the sites where the MEP is elicited in both the FDI and ADM muscles. They were also lateral to those in the ADM muscle elicited either across the sites where the MEP is predominantly elicited in the ADM muscle, or across the sites where the MEP is elicited in both the FDI and ADM muscles. The decrease in the corticospinal excitability and the excitability of the GABA-mediated inhibitory circuits of the primary motor cortex that project onto the corticospinal neurons in the FDI muscle may be due either to (1) the interaction between the activity of the lateral area of the FDI representation and the descending drive to the ADM muscle, or (2) the decreased susceptibility of the primary motor area that predominantly projects onto the corticospinal neurons in the FDI muscle, which also plays a role in independent finger movement when both the FDI and ADM muscles act together as synergists.

  14. Distribution of Primary School Enrollments in Eastern Africa. World Bank Staff Working Papers Number 511.

    ERIC Educational Resources Information Center

    Maas, Jacob van Lutsenburg; Criel, Geert

    Distribution of primary school enrollments within and among 15 countries of the Eastern African region was examined by drawing exclusively on routine annual statistics and by emphasizing simple computer-generated indicators. In its first phase, the study made inter-country comparisons that indicated which countries and which areas in the region…

  15. Measuring circuit

    DOEpatents

    Sun, Shan C.; Chaprnka, Anthony G.

    1977-01-11

    An automatic gain control circuit functions to adjust the magnitude of an input signal supplied to a measuring circuit to a level within the dynamic range of the measuring circuit while a log-ratio circuit adjusts the magnitude of the output signal from the measuring circuit to the level of the input signal and optimizes the signal-to-noise ratio performance of the measuring circuit.

  16. Distributed Hierarchical Control of Multi-Area Power Systems with Improved Primary Frequency Regulation

    SciTech Connect

    Lian, Jianming; Marinovici, Laurentiu D.; Kalsi, Karanjit; Du, Pengwei; Elizondo, Marcelo A.

    2012-12-12

    The conventional distributed hierarchical control architecture for multi-area power systems is revisited. In this paper, a new distributed hierarchical control architecture is proposed. In the proposed architecture, pilot generators are selected in each area to be equipped with decentralized robust control as a supplementary to the conventional droop speed control. With the improved primary frequency control, the system frequency can be restored to the nominal value without the help of secondary frequency control, which reduces the burden of the automatic generation control for frequency restoration. Moreover, the low frequency inter-area electromechanical oscillations can also be effectively damped. The effectiveness of the proposed distributed hierarchical control architecture is validated through detailed simulations.

  17. Experimental facility for the study of acoustic emission registered in the primary circuit components of WWER power units

    NASA Astrophysics Data System (ADS)

    Petrosyan, V. G.; Hovakimyan, T. H.; Yeghoyan, E. A.; Hovhannisyan, H. T.; Mayilyan, D. G.; Petrosyan, A. P.

    2017-01-01

    This paper is dedicated to the creation of a facility for the experimental study of a phenomenon of background acoustic emission (AE), which is detected in the main circulation loop (MCL) of WWER power units. The analysis of the operating principle and the design of a primary feed-and-blow down system (FB) deaerator of NPP as the most likely source of continuous acoustic emission is carried out. The experimental facility for the systematic study of a phenomenon of continuous AE is developed. A physical model of a thermal deaerator is designed and constructed. A thermal monitoring system is introduced. An automatic system providing acoustic signal registration in a low frequency (0.03-30 kHz) and high frequency (30-300 kHz) bands and study of its spectral characteristics is designed. Special software for recording and processing of digitized electrical sensor signals is developed. A separate and independent principle of study of the most probable processes responsible for the generation of acoustic emission signals in the deaerator is applied. Trial series of experiments and prechecks of acoustic signals in different modes of the deaerator model are conducted. Compliance of basic technological parameters with operating range of the real deaerator was provided. It is shown that the acoustic signal time-intensity curve has several typical regions. The pilot research showed an impact of various processes that come about during the operation of the deaerator physical model on the intensity of the AE signal. The experimental results suggest that the main sources of generation of the AE signals are the processes of steam condensation, turbulent flow of gas-vapor medium, and water boiling.

  18. Illumination distribution and signal transmission for indoor visible light communication with different light-emitting diode arrays and pre-equality circuits

    NASA Astrophysics Data System (ADS)

    Chen, Hsi-Chao; Liou, Cheng-Jyun; Siao, Syuan-Ruei

    2015-11-01

    The purpose of this study was to seek the optimal design for light-emitting diode (LED) arrays and pre-equality circuits in indoor visible lighting illumination combined with communication. The optical and communicational properties of illumination distribution and signal transmission were investigated. These illumination distributions of array sources were derivate and simulated and actually can be used in free-space communication. Simulated results show the total flux size was rectangle>radial>circlearray, and real measurements also showed the total flux was rectangle>radial>circlearray. The simulated and measured results have a similarity of over 98% by normalized cross correlation. In addition, when the distance of the installed lamp from the wall was 1 m, the rectangular array had the best illumination uniformity of 77.24%, and the size of uniformity was the rectangle>radial≈circle array. Finally, the gain and constant-current pre-equality circuits were used in free-space communication with a carrier frequency from 1 KHz to 1 MHz at a distance of 1.8 m. Both the received signal intensity and divergence angle were rectangle>radial>circle array. The constant-current pre-equality circuit could add the divergence angle from ±18.6 deg to ±36.68 deg in the rectangle array at a carrier frequency of 1 MHz.

  19. Visualizing Metal Content and Intracellular Distribution in Primary Hippocampal Neurons with Synchrotron X-Ray Fluorescence

    PubMed Central

    2016-01-01

    Increasing evidence suggests that metal dyshomeostasis plays an important role in human neurodegenerative diseases. Although distinctive metal distributions are described for mature hippocampus and cortex, much less is known about metal levels and intracellular distribution in individual hippocampal neuronal somata. To solve this problem, we conducted quantitative metal analyses utilizing synchrotron radiation X-Ray fluorescence on frozen hydrated primary cultured neurons derived from rat embryonic cortex (CTX) and two regions of the hippocampus: dentate gyrus (DG) and CA1. Comparing average metal contents showed that the most abundant metals were calcium, iron, and zinc, whereas metals such as copper and manganese were less than 10% of zinc. Average metal contents were generally similar when compared across neurons cultured from CTX, DG, and CA1, except for manganese that was larger in CA1. However, each metal showed a characteristic spatial distribution in individual neuronal somata. Zinc was uniformly distributed throughout the cytosol, with no evidence for the existence of previously identified zinc-enriched organelles, zincosomes. Calcium showed a peri-nuclear distribution consistent with accumulation in endoplasmic reticulum and/or mitochondria. Iron showed 2–3 distinct highly concentrated puncta only in peri-nuclear locations. Notwithstanding the small sample size, these analyses demonstrate that primary cultured neurons show characteristic metal signatures. The iron puncta probably represent iron-accumulating organelles, siderosomes. Thus, the metal distributions observed in mature brain structures are likely the result of both intrinsic neuronal factors that control cellular metal content and extrinsic factors related to the synaptic organization, function, and contacts formed and maintained in each region. PMID:27434052

  20. Spectral distribution of the open-circuit voltage in pCdTe-nCdTe-nCdS film structures

    NASA Astrophysics Data System (ADS)

    Mirsagatov, Sh. A.; Sabirob, K.; Muzafarova, S. A.

    The spectral distribution of the open-circuit voltage of pCdTe-nCdTe-nCdS film structures is determined experimentally in order to assess the contributions of the various barriers of the structure to the generation of the photo-emf. An analysis of the spectral dependence of the open-circuit voltage indicates that the main sensitivity region of the structure corresponds to the photon energy range 1.46-2.3 eV; i.e., the energy of photoactive photons is equal to or greater than the width of the forbidden zone of CdTe (1.46 eV) and less than the width of the forbidden zone of CdS (2.4 eV). The greatest contribution to photo-emf generation is made by the homojunction in CdTe.

  1. Primary and Aggregate Size Distributions of PM in Tail Pipe Emissions form Diesel Engines

    NASA Astrophysics Data System (ADS)

    Arai, Masataka; Amagai, Kenji; Nakaji, Takayuki; Hayashi, Shinji

    Particulate matter (PM) emission exhausted from diesel engine should be reduced to keep the clean air environment. PM emission was considered that it consisted of coarse and aggregate particles, and nuclei-mode particles of which diameter was less than 50nm. However the detail characteristics about these particles of the PM were still unknown and they were needed for more physically accurate measurement and more effective reduction of exhaust PM emission. In this study, the size distributions of solid particles in PM emission were reported. PMs in the tail-pipe emission were sampled from three type diesel engines. Sampled PM was chemically treated to separate the solid carbon fraction from other fractions such as soluble organic fraction (SOF). The electron microscopic and optical-manual size measurement procedures were used to determine the size distribution of primary particles those were formed through coagulation process from nuclei-mode particles and consisted in aggregate particles. The centrifugal sedimentation method was applied to measure the Stokes diameter of dry-soot. Aerodynamic diameters of nano and aggregate particles were measured with scanning mobility particle sizer (SMPS). The peak aggregate diameters detected by SMPS were fallen in the same size regime as the Stokes diameter of dry-soot. Both of primary and Stokes diameters of dry-soot decreased with increases of engine speed and excess air ratio. Also, the effects of fuel properties and engine types on primary and aggregate particle diameters were discussed.

  2. 30 CFR 77.800 - High-voltage circuits; circuit breakers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-voltage circuits; circuit breakers. 77.800... COAL MINES Surface High-Voltage Distribution § 77.800 High-voltage circuits; circuit breakers. High-voltage circuits supplying power to portable or mobile equipment shall be protected by suitable...

  3. Supply and distribution of primary healthcare registered nurses in british columbia.

    PubMed

    Wong, Sabrina T; Watson, Diane E; Young, Ella; Mooney, Dawn

    2009-11-01

    WHAT DID WE DO?: This study uses an existing data source to (a) describe the population and geographic distribution of registered nurses (RNs) working in primary healthcare (PHC) in British Columbia, (b) compare this workforce to PHC physicians and (c) assess the distribution of PHC-RNs relative to population health status. WHAT DID WE LEARN?: Of the 27,570 practising RNs in British Columbia in 2000, there were 3,179 (12%) in the PHC workforce. This translates into 147 people per practising RN and 1,277 people per PHC-RN. In 2000, there were 990 people per PHC physician. PHC-RNs represented 43% of the combined PHC workforce of physicians and RNs. A large proportion (47%) of PHC-RNs worked in community health centres, whereas less than 2% worked in physicians' offices. Geographic distribution of PHC-RNs is similar to the distribution of PHC physicians and is not associated with population health status. WHAT ARE THE IMPLICATIONS?: There seem to be sufficient PHC-RNs to implement policy objectives in support of interdisciplinary PHC teams, but physicians and nurses will increasingly need to practice in the same location or have access to electronic information systems to support coordination, continuity and comprehensiveness of PHC. The PHC workforce could be better deployed to align with population health status.

  4. Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage

    PubMed Central

    Tsai, Hsin-Hsi; Tsai, Li-Kai; Chen, Ya-Fang; Tang, Sung-Chun; Lee, Bo-Ching; Yen, Ruoh-Fang; Jeng, Jiann-Shing

    2017-01-01

    The underlying pathology of cerebral microbleeds (CMBs) with mixed lobar and deep distribution remains contentious. The aim of this study was to correlate CMBs distribution to β-amyloid burden in patients with primary intracerebral hemorrhage (ICH). Fourty-seven ICH patients underwent magnetic resonance susceptibility-weighted imaging and 11C-Pittsburgh Compound B positron emission tomography. The amyloid burden was expressed as standardized uptake value ratio with reference to cerebellum, and presented as median (interquartile range). Patients were categorized into the lobar, mixed (both lobar and deep regions), and deep types of CMB. Comparing the lobar (17%), mixed (59.6%) and deep (23.4%) CMB types, the global amyloid burden was significantly higher in the mixed type than the deep type (1.10 [1.03–1.25] vs 1.00 [0.97–1.09], p = 0.011), but lower than in the lobar type (1.48 [1.18–1.50], p = 0.048). On multivariable analysis, the ratio of lobar to deep CMB number was positively correlated with global (p = 0.028) and occipital (p = 0.031) amyloid burden. In primary ICH, patients with lobar and mixed CMB types are associated with increased amyloid burden than patients with deep type. The ratio of lobar to deep CMB number is an independent indicator of cerebral β-amyloid deposition. PMID:28303922

  5. X-ray fluorescence analysis of iron and manganese distribution in primary dopaminergic neurons

    PubMed Central

    Dučić, Tanja; Barski, Elisabeth; Salome, Murielle; Koch, Jan C; Bähr, Mathias; Lingor, Paul

    2013-01-01

    Transition metals have been suggested to play a pivotal role in the pathogenesis of Parkinson's disease. X-ray microscopy combined with a cryogenic setup is a powerful method for elemental imaging in low concentrations and high resolution in intact cells, eliminating the need for fixation and sectioning of the specimen. Here, we performed an elemental distribution analysis in cultured primary midbrain neurons with a step size in the order of 300 nm and ∼ 0.1 ppm sensitivity under cryo conditions by using X-ray fluorescence microscopy. We report the elemental mappings on the subcellular level in primary mouse dopaminergic (DAergic) and non-DAergic neurons after treatment with transition metals. Application of Fe2+ resulted in largely extracellular accumulation of iron without preference for the neuronal transmitter subtype. A quantification of different Fe oxidation states was performed using X-ray absorption near edge structure analysis. After treatment with Mn2+, a cytoplasmic/paranuclear localization of Mn was observed preferentially in DAergic neurons, while no prominent signal was detectable after Mn3+ treatment. Immunocytochemical analysis correlated the preferential Mn uptake to increased expression of voltage-gated calcium channels in DAergic neurons. We discuss the implications of this differential elemental distribution for the selective vulnerability of DAergic neurons and Parkinson's disease pathogenesis. PMID:23106162

  6. ADDER CIRCUIT

    DOEpatents

    Jacobsohn, D.H.; Merrill, L.C.

    1959-01-20

    An improved parallel addition unit is described which is especially adapted for use in electronic digital computers and characterized by propagation of the carry signal through each of a plurality of denominationally ordered stages within a minimum time interval. In its broadest aspects, the invention incorporates a fast multistage parallel digital adder including a plurality of adder circuits, carry-propagation circuit means in all but the most significant digit stage, means for conditioning each carry-propagation circuit during the time period in which information is placed into the adder circuits, and means coupling carry-generation portions of thc adder circuit to the carry propagating means.

  7. Progressive Changes in a Distributed Neural Circuit Underlie Breathing Abnormalities in Mice Lacking MeCP2

    PubMed Central

    Huang, Teng-Wei; Kochukov, Mikhail Y.; Ward, Christopher S.; Merritt, Jonathan; Thomas, Kaitlin; Nguyen, Tiffani; Arenkiel, Benjamin R.

    2016-01-01

    Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in Methyl-CpG-binding protein 2 (MECP2). Severe breathing abnormalities are common in RTT and are reproduced in mouse models of RTT. Previously, we found that removing MeCP2 from the brainstem and spinal cord in mice caused early lethality and abnormal breathing. To determine whether loss of MeCP2 in functional components of the respiratory network causes specific breathing disorders, we used the Cre/LoxP system to differentially manipulate MeCP2 expression throughout the brainstem respiratory network, specifically within HoxA4-derived tissues, which include breathing control circuitry within the nucleus tractus solitarius and the caudal part of ventral respiratory column but do not include more rostral parts of the breathing control circuitry. To determine whether respiratory phenotypes manifested in animals with MeCP2 removed from specific pons medullary respiratory circuits, we performed whole-body plethysmography and electrophysiological recordings from in vitro brainstem slices from mice lacking MeCP2 in different circuits. Our results indicate that MeCP2 expression in the medullary respiratory network is sufficient for normal respiratory rhythm and preventing apnea. However, MeCP2 expression within components of the breathing circuitry rostral to the HoxA4 domain are neither sufficient to prevent the hyperventilation nor abnormal hypoxic ventilatory response. Surprisingly, we found that MeCP2 expression in the HoxA4 domain alone is critical for survival. Our study reveals that MeCP2 is differentially required in select respiratory components for different aspects of respiratory functions, and collectively for the integrity of this network functions to maintain proper respiration. SIGNIFICANCE STATEMENT Breathing abnormalities are a significant clinical feature in Rett syndrome and are robustly reproduced in the mouse models of this disease. Previous work has established that alterations

  8. Epithelial to Stromal Re-Distribution of Primary Cilia during Pancreatic Carcinogenesis

    PubMed Central

    Schimmack, Simon; Kneller, Sarah; Dadabaeva, Nigora; Bergmann, Frank; Taylor, Andrew; Hackert, Thilo; Werner, Jens; Strobel, Oliver

    2016-01-01

    Background The Hedgehog (HH) pathway is a mediator in pancreatic ductal adenocarcinoma (PDAC). Surprisingly, previous studies suggested that primary cilia (PC), the essential organelles for HH signal transduction, were lost in PDAC. The aim of this study was to determine the presence of PC in human normal pancreas, chronic pancreatitis, and during carcinogenesis to PDAC with focus on both epithelia and stroma. Methods PC were analyzed in paraffin sections from normal pancreas, chronic pancreatitis, intraductal papillary-mucinous neoplasia, and PDAC, as well as in primary human pancreatic stellate cells (PSC) and pancreatic cancer cell lines by double immunofluorescence staining for acetylated α-tubuline and γ-tubuline. Co-staining for the HH receptors PTCH1, PTCH2 and SMO was also performed. Results PC are gradually lost during pancreatic carcinogenesis in the epithelium: the fraction of cells with PC gradually and significantly decreased from 32% in ducts of normal pancreas, to 21% in ducts of chronic pancreatitis, to 18% in PanIN1a, 6% in PanIN2, 3% in PanIN3 and to 1.2% in invasive PDAC. However, this loss of PC in the neoplastic epithelium is accompanied by a gain of PC in the surrounding stroma. The fraction of stromal cells with PC significantly increased from 13% around normal ducts to about 30% around PanIN and PDAC. HH-receptors were detected in tumor stroma but not in epithelial cells. PC are also present in PSC and pancreatic cancer cell lines. Conclusion PC are not lost during pancreatic carcinogenesis but re-distributed from the epithelium to the stroma. This redistribution may explain the re-direction of HH signaling towards the stroma during pancreatic carcinogenesis. PMID:27783689

  9. Measuring the distribution of cellulose microfibril angles in primary cell walls by small angle X-ray scattering

    PubMed Central

    2014-01-01

    Background X-ray scattering is a well-established method for measuring cellulose microfibril angles in secondary cell walls. However, little data is available on the much thinner primary cell walls. Here, we show that microfibril orientation distributions can be determined by small angle X-ray scattering (SAXS) even in primary cell walls. The technique offers a number of advantages: samples can be analyzed in the native hydrated state without any preparation which minimizes the risk of artifacts and allows for fast data acquisition. The method provides data averaged over a specimen region, determined by the size of the used X-ray beam and, thus, yields the microfibril orientation distribution within this region. Results Cellulose microfibril orientation distributions were obtained for single cells of the alga Chara corallina, as well as for the multicellular hypocotyl of Arabidopsis thaliana. In both, Chara and Arabidopsis, distributions with a broad scattering around mean microfibril angles of approximately 0° and 90° towards the longitudinal axis of the cells were found. Conclusions With SAXS, the structure of primary cell walls can be analysed in their native state and new insights into the cellulose microfibril orientation of primary cell walls can be gained. The data shows that SAXS can serve as a valuable tool for the analysis of cellulose microfibril orientation in primary cell walls and, in consequence, add to the understanding of its mechanical behaviour and the intriguing mechanisms behind cell growth. PMID:25170343

  10. Phenology of particle size distributions and primary productivity in the North Pacific subtropical gyre (Station ALOHA)

    NASA Astrophysics Data System (ADS)

    White, Angelicque E.; Letelier, Ricardo M.; Whitmire, Amanda L.; Barone, Benedetto; Bidigare, Robert R.; Church, Matthew J.; Karl, David M.

    2015-11-01

    The particle size distribution (PSD) is a critical aspect of the oceanic ecosystem. Local variability in the PSD can be indicative of shifts in microbial community structure and reveal patterns in cell growth and loss. The PSD also plays a central role in particle export by influencing settling speed. Satellite-based models of primary productivity (PP) often rely on aspects of photophysiology that are directly related to community size structure. In an effort to better understand how variability in particle size relates to PP in an oligotrophic ecosystem, we collected laser diffraction-based depth profiles of the PSD and pigment-based classifications of phytoplankton functional types (PFTs) on an approximately monthly basis at the Hawaii Ocean Time-series Station ALOHA, in the North Pacific subtropical gyre. We found a relatively stable PSD in the upper water column. However, clear seasonality is apparent in the vertical distribution of distinct particle size classes. Neither laser diffraction-based estimations of relative particle size nor pigment-based PFTs was found to be significantly related to the rate of 14C-based PP in the light-saturated upper euphotic zone. This finding indicates that satellite retrievals of particle size, based on particle scattering or ocean color would not improve parameterizations of present-day bio-optical PP models for this region. However, at depths of 100-125 m where irradiance exerts strong control on PP, we do observe a significant linear relationship between PP and the estimated carbon content of 2-20 μm particles.

  11. Phenology of particle size distributions and primary productivity in the North Pacific subtropical gyre (Station ALOHA)

    PubMed Central

    Letelier, Ricardo M.; Whitmire, Amanda L.; Barone, Benedetto; Bidigare, Robert R.; Church, Matthew J.; Karl, David M.

    2015-01-01

    Abstract The particle size distribution (PSD) is a critical aspect of the oceanic ecosystem. Local variability in the PSD can be indicative of shifts in microbial community structure and reveal patterns in cell growth and loss. The PSD also plays a central role in particle export by influencing settling speed. Satellite‐based models of primary productivity (PP) often rely on aspects of photophysiology that are directly related to community size structure. In an effort to better understand how variability in particle size relates to PP in an oligotrophic ecosystem, we collected laser diffraction‐based depth profiles of the PSD and pigment‐based classifications of phytoplankton functional types (PFTs) on an approximately monthly basis at the Hawaii Ocean Time‐series Station ALOHA, in the North Pacific subtropical gyre. We found a relatively stable PSD in the upper water column. However, clear seasonality is apparent in the vertical distribution of distinct particle size classes. Neither laser diffraction‐based estimations of relative particle size nor pigment‐based PFTs was found to be significantly related to the rate of 14C‐based PP in the light‐saturated upper euphotic zone. This finding indicates that satellite retrievals of particle size, based on particle scattering or ocean color would not improve parameterizations of present‐day bio‐optical PP models for this region. However, at depths of 100–125 m where irradiance exerts strong control on PP, we do observe a significant linear relationship between PP and the estimated carbon content of 2–20 μm particles. PMID:27812434

  12. MULTIPLIER CIRCUIT

    DOEpatents

    Thomas, R.E.

    1959-01-20

    An electronic circuit is presented for automatically computing the product of two selected variables by multiplying the voltage pulses proportional to the variables. The multiplier circuit has a plurality of parallel resistors of predetermined values connected through separate gate circults between a first input and the output terminal. One voltage pulse is applied to thc flrst input while the second voltage pulse is applied to control circuitry for the respective gate circuits. Thc magnitude of the second voltage pulse selects the resistors upon which the first voltage pulse is imprcssed, whereby the resultant output voltage is proportional to the product of the input voltage pulses

  13. GATING CIRCUITS

    DOEpatents

    Merrill, L.C.

    1958-10-14

    Control circuits for vacuum tubes are described, and a binary counter having an improved trigger circuit is reported. The salient feature of the binary counter is the application of the input signal to the cathode of each of two vacuum tubes through separate capacitors and the connection of each cathode to ground through separate diodes. The control of the binary counter is achieved in this manner without special pulse shaping of the input signal. A further advantage of the circuit is the simplicity and minimum nuruber of components required, making its use particularly desirable in computer machines.

  14. Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: a review of lesion distribution and circuit disconnection in cortical visual pathways

    NASA Technical Reports Server (NTRS)

    Hof, P. R.; Vogt, B. A.; Bouras, C.; Morrison, J. H.; Bloom, F. E. (Principal Investigator)

    1997-01-01

    In recent years, the existence of visual variants of Alzheimer's disease characterized by atypical clinical presentation at onset has been increasingly recognized. In many of these cases post-mortem neuropathological assessment revealed that correlations could be established between clinical symptoms and the distribution of neurodegenerative lesions. We have analyzed a series of Alzheimer's disease patients presenting with prominent visual symptomatology as a cardinal sign of the disease. In these cases, a shift in the distribution of pathological lesions was observed such that the primary visual areas and certain visual association areas within the occipito-parieto-temporal junction and posterior cingulate cortex had very high densities of lesions, whereas the prefrontal cortex had fewer lesions than usually observed in Alzheimer's disease. Previous quantitative analyses have demonstrated that in Alzheimer's disease, primary sensory and motor cortical areas are less damaged than the multimodal association areas of the frontal and temporal lobes, as indicated by the laminar and regional distribution patterns of neurofibrillary tangles and senile plaques. The distribution of pathological lesions in the cerebral cortex of Alzheimer's disease cases with visual symptomatology revealed that specific visual association pathways were disrupted, whereas these particular connections are likely to be affected to a less severe degree in the more common form of Alzheimer's disease. These data suggest that in some cases with visual variants of Alzheimer's disease, the neurological symptomatology may be related to the loss of certain components of the cortical visual pathways, as reflected by the particular distribution of the neuropathological markers of the disease.

  15. Pattern and distribution of ocular morbidity in primary school children of rural Delhi.

    PubMed

    Chaturvedi, S; Aggarwal, O P

    1999-01-01

    A total of 679 primary school children drawn from developed southern parts and underdeveloped eastern parts of Delhi were examined for ocular morbidity. Their age range was 5-15 years and both sexes had almost equal representation. The prevalence of eye diseases was relatively high. Over 40 percent of all the children studied had one or more ocular problems. Trachoma (18%) was the most common ocular morbidity followed by vitamin A deficiency (10.6%), visual acuity < 6/9 (7.4%) and apparent/latent squint (7.4%). In most of these eye disorders, the majority of the children came from the underdeveloped eastern parts of Delhi. Ocular morbidity seems to be unevenly distributed in rural Delhi with a significantly worse picture in the underdeveloped eastern parts, across the river 'Yamuna'. Though blinding trachoma may cease to be a major problem in India, the country continues to have endemic pockets of its non-blinding form. One puzzling observation was that children with protein-energy malnutrition (PEM) did not show any specific vulnerability to ocular diseases. In fact, those with normal weight-height index were having a higher share of eye diseases. Though this issue needs to be explored further in the light of biological plausibility, it appears that children who do not have PEM are also exposed to ocular diseases at least with comparable risk.

  16. Global intraurban intake fractions for primary air pollutants from vehicles and other distributed sources.

    PubMed

    Apte, Joshua S; Bombrun, Emilie; Marshall, Julian D; Nazaroff, William W

    2012-03-20

    We model intraurban intake fraction (iF) values for distributed ground-level emissions in all 3646 global cities with more than 100,000 inhabitants, encompassing a total population of 2.0 billion. For conserved primary pollutants, population-weighted median, mean, and interquartile range iF values are 26, 39, and 14-52 ppm, respectively, where 1 ppm signifies 1 g inhaled/t emitted. The global mean urban iF reported here is roughly twice as large as previous estimates for cities in the United States and Europe. Intake fractions vary among cities owing to differences in population size, population density, and meteorology. Sorting by size, population-weighted mean iF values are 65, 35, and 15 ppm, respectively, for cities with populations larger than 3, 0.6-3, and 0.1-0.6 million. The 20 worldwide megacities (each >10 million people) have a population-weighted mean iF of 83 ppm. Mean intraurban iF values are greatest in Asia and lowest in land-rich high-income regions. Country-average iF values vary by a factor of 3 among the 10 nations with the largest urban populations.

  17. Myosin-Va Mediates RNA Distribution in Primary Fibroblasts From Multiple Organs

    PubMed Central

    Salerno, Verônica P.; Calliari, Aldo; William Provance, D.; Sotelo-Silveira, José R.; Sotelo, José R.; Mercer, John A.

    2008-01-01

    Myosin-Va has been shown to have multiple functions in a variety of cell types, including a role in RNA transport in neurons. Using primary cultures of cells from organs of young dilute-lethal (Myo5ad-l/Myo5ad-l) null mutant mice and wild-type controls, we show that in some, but not all, tissues, RNA distribution is dramatically different in the homozygous null mutant cells. The dependence of RNA localization on myosin-Va correlates with the relative abundance of the brain-specific splicing pattern of the myosin-Va tail. We also show that myosin-Va is involved in RNA localization soon after synthesis, because the effects of its absence are diminished for RNAs that are more than 30 min old. Finally, we show that localization of β-actin mRNA is significantly changed by the absence of myosin-Va. These results suggest that myosin-Va is involved in a transient transport or tethering function in the perinuclear region. Cell Motil. PMID:18357619

  18. Concordant genetic structure in two species of woodpecker distributed across the primary West African biogeographic barriers.

    PubMed

    Fuchs, Jérôme; Bowie, Rauri C K

    2015-07-01

    The lowland forests of western and central tropical Africa are separated by several potential biogeographic barriers to dispersal for forest adapted vertebrates. The two primary barriers are (1) the Dahomey Gap, a savanna corridor that reaches the coast of southern Ghana, Togo and Benin, and separates the West African rainforest into the Upper (Ghana west to Guinea) and Lower Guinea (Nigeria to Uganda and Angola) forest blocks, and (2) the Lower Niger River, a large delta that separates Western and Eastern Nigeria. Previous studies on terrestrial vertebrates (lizards, mammals and birds) have highlighted a genetic break in the Dahomey Gap/Lower Niger River area although the relative importance of each barrier has not been assessed due to limitations in geographic sampling. We compared the phylogeographic history of two co-distributed sister-species of woodpeckers (Campethera caroli and C. nivosa) using data from three loci representing all inheritance modes. Our analyses revealed that both the Dahomey Gap and possibly the Lower Niger River acted as strong biogeographic barriers for the two woodpecker species, with the Lower Niger River being the first barrier to have formed, leading to three distinct populations of C. nivosa. Our divergence time analyses revealed that both these biogeographic barriers formed during the Pleistocene, supporting the Pleistocene refuge hypothesis, with the Dahomey Gap likely appearing about 0.5 myr BP. No genetic structure was recovered among sampled populations in either the Upper or the Lower Guinea Forest Block for both species, despite the considerable geographic area covered.

  19. The Social Distribution of Primary Social Isolation among the Aged: A Subcultural Approach.

    ERIC Educational Resources Information Center

    Rutzen, S. Robert

    1980-01-01

    Examines subcultural variations in primary social isolation in older persons in Albany. Seven hypothetical subcultures contain enough respondents to be numerically important. Two subcultures have above-average rates of primary social isolation. Three subcultures have below-average rates. Results indicate that primary social isolation is a group…

  20. TRIPPING CIRCUIT

    DOEpatents

    Lees, G.W.; McCormick, E.D.

    1962-05-22

    A tripping circuit employing a magnetic amplifier for tripping a reactor in response to power level, period, or instrument failure is described. A reference winding and signal winding are wound in opposite directions on the core. Current from an ion chamber passes through both windings. If the current increases at too fast a rate, a shunt circuit bypasses one or the windings and the amplifier output reverses polarity. (AEC)

  1. Integrated-Circuit Pseudorandom-Number Generator

    NASA Technical Reports Server (NTRS)

    Steelman, James E.; Beasley, Jeff; Aragon, Michael; Ramirez, Francisco; Summers, Kenneth L.; Knoebel, Arthur

    1992-01-01

    Integrated circuit produces 8-bit pseudorandom numbers from specified probability distribution, at rate of 10 MHz. Use of Boolean logic, circuit implements pseudorandom-number-generating algorithm. Circuit includes eight 12-bit pseudorandom-number generators, outputs are uniformly distributed. 8-bit pseudorandom numbers satisfying specified nonuniform probability distribution are generated by processing uniformly distributed outputs of eight 12-bit pseudorandom-number generators through "pipeline" of D flip-flops, comparators, and memories implementing conditional probabilities on zeros and ones.

  2. The Global Circuit.

    ERIC Educational Resources Information Center

    Lansford, Henry

    1983-01-01

    Discusses the nature of and research related to a theory explaining the earth's electric budget. The theory suggests a global electric circuit completed by a positive current flowing up into thunderstorm clouds, from clouds to ionosphere, distributed around the globe, and down to earth through the lower atmosphere in fair-weather regions. (JN)

  3. NOx Emission Reduction by the Optimization of the Primary Air Distribution in the 235Mwe CFB Boiler

    NASA Astrophysics Data System (ADS)

    Mirek, P.; Czakiert, T.; Nowak, W.

    The article presents the results of experimental studies conducted on a large-scale 235 MWe CFB (Circulating Fluidized Bed) boiler, in which the primary air distribution system was modified. The modification was connected with the change of internal geometry of primary air channels as well as internal space of plenum chamber. The obtained results have shown, that the optimization of primary air flow has a great influence on the intensity of the combustion process and the temperature distribution along the height of combustion chamber. As a result, the NOx emission has been reduced by up to ten percent and the temperature profile in the combustion chamber has been revealed to be more uniform.

  4. Distribution of Local Open-Circuit Voltage on Amorphous and Nanocrystalline Mixed-Phase Si:H and SiGe:H Solar Cells: Preprint

    SciTech Connect

    Jiang, C.-S.; Moutinho, H. R.; Al-Jassim, M. M.; Kazmerski, L. L.; Yan, B.; Owens, J. M.; Yang, J.; Guha, S.

    2006-05-01

    Local open-circuit voltage (Voc) distributions on amorphous and nanocrystalline mixed-phase silicon solar cells were measured using a scanning Kelvin probe microscope (SKPM) on the p layer of an n-i-p structure without the top ITO contact. During the measurement, the sample was illuminated with a laser beam that was used for the atomic force microscopy (AFM). Therefore, the surface potential measured by SKPM is the sum of the local Voc and the difference in workfunction between the p layer and the AFM tip. Comparing the SKPM and AFM images, we find that nanocrystallites aggregate in the amorphous matrix with an aggregation size of {approx}0.5 ..mu..m in diameter, where many nanometer-size grains are clustered. The Voc distribution shows valleys in the nanocrystalline aggregation area. The transition from low to high Voc regions is a gradual change within a distance of about 1 ..mu..m. The minimum Voc value in the nanocrystalline clusters in the mixed-phase region is larger than the Voc of a nc-Si:H single-phase solar cell. These results could be due to lateral photo-charge redistribution between the two phases. We have also carried out local Voc measurements on mixed-phase SiGe:H alloy solar cells. The magnitudes of Voc in the amorphous and nanocrystalline regions are consistent with the J-V measurements.

  5. Targeting circuits

    PubMed Central

    Rajasethupathy, Priyamvada; Ferenczi, Emily; Deisseroth, Karl

    2017-01-01

    Current optogenetic methodology enables precise inhibition or excitation of neural circuits, spanning timescales as needed from the acute (milliseconds) to the chronic (many days or more), for experimental modulation of network activity and animal behavior. Such broad temporal versatility, unique to optogenetic control, is particularly powerful when combined with brain activity measurements that span both acute and chronic timescales as well. This enables, for instance, the study of adaptive circuit dynamics across the intact brain, and tuning interventions to match activity patterns naturally observed during behavior in the same individual. Although the impact of this approach has been greater on basic research than on clinical translation, it is natural to ask if specific neural circuit activity patterns discovered to be involved in controlling adaptive or maladaptive behaviors could become targets for treatment of neuropsychiatric diseases. Here we consider the landscape of such ideas related to therapeutic targeting of circuit dynamics, taking note of developments not only in optical but also in ultrasonic, magnetic, and thermal methods. We note the recent emergence of first-in-kind optogenetically-guided clinical outcomes, as well as opportunities related to the integration of interventions and readouts spanning diverse circuit-physiology, molecular, and behavioral modalities. PMID:27104976

  6. Trigger Circuit.

    DTIC Science & Technology

    A wire of Nitinol can be stretched up to a given amount and will remain in this stretched state until heated to a critical temperature. When heated...circuit of this invention provides a current pulse for the required time period to heat the Nitinol wire to its critical temperature to thereby restore the...wire to its original length. The circuit includes a high power transistor which is gated on for a controlled time to provide the required power to heat the Nitinol wire to its critical temperature. (Author)

  7. MULTIPLIER CIRCUIT

    DOEpatents

    Chase, R.L.

    1963-05-01

    An electronic fast multiplier circuit utilizing a transistor controlled voltage divider network is presented. The multiplier includes a stepped potentiometer in which solid state or transistor switches are substituted for mechanical wipers in order to obtain electronic switching that is extremely fast as compared to the usual servo-driven mechanical wipers. While this multiplier circuit operates as an approximation and in steps to obtain a voltage that is the product of two input voltages, any desired degree of accuracy can be obtained with the proper number of increments and adjustment of parameters. (AEC)

  8. Distribution of primary afferent fibres in the cochlear nuclei. A silver and horseradish peroxidase (HRP) study.

    PubMed Central

    Merchan, M A; Collia, F P; Merchan, J A; Saldana, E

    1985-01-01

    Horseradish peroxidase, when injected intracochlearly, is transported transganglionically to the brain stem cochlear nuclei, thus providing an excellent method for tracing the central projection of the spiral ganglion neurons. Silver impregnation using the Cajal-de Castro method, which stains axons even when inside the bone, was used as a reference technique. The combination of both procedures led to the following conclusions. Primary cochlear afferents are found only in the ventral zone of the dorsal cochlear nucleus. In this area they cover the deep and fusiform cell layers. The molecular layer shows no HRP label. The higher concentration of primary cochlear afferents in the ventral cochlear nucleus appears in its central zone; wide areas in this nucleus are not labelled at all. A thin bundle of primary cochlear afferents runs parallel to, and beneath, the granular region. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 PMID:4077711

  9. Angular and energy distribution for parent primaries of cosmic muons at the sea level using Geant4

    NASA Astrophysics Data System (ADS)

    Arslan, Halil; Bektasoglu, Mehmet

    2015-04-01

    The angular and energy distributions of the primary cosmic rays that are responsible for the muons reaching the sea level have been estimated using the Geant4 simulation package. The models used in the simulations were tested by comparing the simulation results for the differential muon flux with the BESS measurements performed in Lynn Lake, Canada. Then, direct relationship between the propagation directions of the muons and those of the responsible primary particles has been investigated. The median energies for the parent primaries of vertical muons reaching the sea level with the threshold energies (Eμ) in the range 0.5-300 GeV were obtained. Simulation results for the median primary energies, 15.5Eμ and 11.2Eμ for Eμ = 14 GeV and Eμ = 100 GeV, have been found to be in good agreement with the literature. Furthermore, median primary energies for the low energy muons with large zenith angle have been seen to be relatively higher than the ones for the muons with narrower angles.

  10. Multiple output power supply circuit for an ion engine with shared upper inverter

    NASA Technical Reports Server (NTRS)

    Cardwell, Jr., Gilbert I. (Inventor); Phelps, Thomas K. (Inventor)

    2001-01-01

    A power supply circuit for an ion engine suitable for a spacecraft is coupled to a bus having a bus input and a bus return. The power supply circuit has a first primary winding of a first transformer. An upper inverter circuit is coupled to the bus input and the first primary winding. The power supply circuit further includes a first lower inverter circuit coupled to the bus return and the first primary winding. The second primary winding of a second transformer is coupled to the upper inverter circuit. A second lower inverter circuit is coupled to the bus return and the second primary winding.

  11. Primary oxidation variation and distribution of uranium and thorium in a lava flow.

    PubMed

    Watkins, N D; Holmes, C W; Haggerty, S E

    1967-02-03

    An Icelandic basalt lava flow has a systematic oxidation variation, formed during the initial cooling, with a resultant maximum oxidation just below the center of the lava. The ratio of thorium to uranium shows a clear dependence on this primary oxidation variation. Between-lava comparisons of thorium and uranium may be critically dependent on the position of the samples in each lava.

  12. How Primary School Students Understand Mains Electricity and Its Distribution. Research Report

    ERIC Educational Resources Information Center

    Pilatou, Vassiliki; Stavridou, Heleni

    2004-01-01

    The aim of this study was to detect primary students' conceptions about the origin and conveyance of electric current and about the connection of household electric appliances. In total, 383 students (aged 11-12) from the town of Volos, Greece, participated; 213 of them drawn from experimental classes and 170 from control groups. The results…

  13. Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons.

    PubMed

    Bao, Lan

    2015-09-30

    Voltage-gated sodium channels (Navs) comprise at least nine pore-forming α subunits. Of these, Nav1.6, Nav1.7, Nav1.8 and Nav1.9 are the most frequently studied in primary sensory neurons located in the dorsal root ganglion and are mainly localized to the cytoplasm. A large pool of intracellular Navs raises the possibility that changes in Nav trafficking could alter channel function. The molecular mediators of Nav trafficking mainly consist of signals within the Navs themselves, interacting proteins and extracellular factors. The surface expression of Navs is achieved by escape from the endoplasmic reticulum and proteasome degradation, forward trafficking and plasma membrane anchoring, and it is also regulated by channel phosphorylation and ubiquitination in primary sensory neurons. Axonal transport and localization of Navs in afferent fibers involves the motor protein KIF5B and scaffold proteins, including contactin and PDZ domain containing 2. Localization of Nav1.6 to the nodes of Ranvier in myelinated fibers of primary sensory neurons requires node formation and the submembrane cytoskeletal protein complex. These findings inform our understanding of the molecular and cellular mechanisms underlying Nav trafficking in primary sensory neurons.

  14. Uneven Distribution of Novice Teachers in the Chilean Primary School System

    ERIC Educational Resources Information Center

    Meckes, Lorena; Bascope, Martin

    2012-01-01

    This study examines the allocation of novice primary teachers in Chilean schools, looking at their characteristics and at the attributes of the schools at which they are hired after having completed their initial teacher training. The study reveals that in Chile, more qualified novice teachers are more prone to get jobs in socio-economically…

  15. Thermionic integrated circuits

    SciTech Connect

    MacRoberts, M.; Brown, D.R.; Dooley, R.; Lemons, R.; Lynn, D.; McCormick, B.; Mombourquette, C.; Sinah, D.

    1986-01-01

    Thermionic integrated circuits combine vacuum-tube technology with integrated-circuit techniques to form integrated vacuum circuits. These circuits are capable of extended operation in both high-temperature and high-radiation environments.

  16. History of Physics as a Tool to Detect the Conceptual Difficulties Experienced by Students: The Case of Simple Electric Circuits in Primary Education

    ERIC Educational Resources Information Center

    Leone, Matteo

    2014-01-01

    The present paper advocates the use of History of Science into the teaching of science in primary education through a case study in the field of electricity. In this study, which provides both historical and experimental evidence, a number of conceptual difficulties faced by early nineteenth century physicists are shown to be a useful tool to…

  17. Time of appearance and distribution of cells capable of secondary immune response following primary immunization

    PubMed Central

    Vischer, T. L.; Stastny, P.

    1967-01-01

    Immunological memory was studied by measurement of tritiated thymidine incorporation in tissue culture. After primary immunization with keyhole limpet haemocyanin (KLH) secondary responsiveness could be detected as early as the 2nd day after immunization with Freund's adjuvant into the footpads and on the 4th day after injection of KLH intravenously. In each case immunological memory developed first in the area of the injection, that is, the popliteal lymph nodes after footpad immunization and the spleen after intravenous injection. The secondary response could also be detected in the lymphoid cells of the blood. Cell suspensions enriched in small lymphocytes showed a similar reactivity. Cells from the thymus, however, did not develop immunological memory. Rabbits immunized with BSA showed a relatively weaker response which was clearly detectable only when Freund's adjuvant was used for immunization. The results suggest that a response essentially of a secondary type may play an important role in what is usually considered the primary immune response. PMID:6027423

  18. THE ANALYTICAL STRUCTURE OF THE PRIMARY INTERSTELLAR HELIUM DISTRIBUTION FUNCTION IN THE HELIOSPHERE

    SciTech Connect

    Lee, Martin A.; Möbius, Eberhard; Leonard, Trevor W.

    2015-10-15

    A new analytical model based on the previous work of Lee et al. is presented for the distribution of interstellar helium in the heliosphere. The model is tailored for comparison with the IBEX-Lo observations in order to determine the bulk velocity and temperature of helium in the local interstellar cloud. The model includes solar gravity, spherically symmetric stationary ionization rates, transformation to the Earth/IBEX frame of reference, the IBEX viewing geometry with small spin-axis tilt, and integration of the atom differential intensity over energy and the instrument collimator solid angle. The analysis employs an expansion of the count rate about the peak of the velocity distribution to second order in the magnitudes of several small quantities: the ratio of the helium thermal speed to its bulk speed, the angle between the bulk velocity and the ecliptic, the two angles describing the tilt of the IBEX spin-axis away from Sun-pointing, the collimator angular width, and the angular difference between the observing longitude and the longitude where the projection of the bulk velocity onto the ecliptic is tangential to Earth's orbit. The model reveals the evolving ellipsoidal shape of the helium distribution as it moves along its average hyperbolic orbit. For specified interstellar parameters, the model predicts the latitudinal and longitudinal structure of the helium distribution. The model is in reasonable agreement with IBEX observations and the predictions of the other available models.

  19. 46 CFR 111.75-5 - Lighting branch circuits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Lighting branch circuits. 111.75-5 Section 111.75-5...-GENERAL REQUIREMENTS Lighting Circuits and Protection § 111.75-5 Lighting branch circuits. (a) Loads. A lighting distribution panel must not supply branch circuits rated at over 30 amperes. (b) Connected...

  20. 46 CFR 111.75-5 - Lighting branch circuits.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Lighting branch circuits. 111.75-5 Section 111.75-5...-GENERAL REQUIREMENTS Lighting Circuits and Protection § 111.75-5 Lighting branch circuits. (a) Loads. A lighting distribution panel must not supply branch circuits rated at over 30 amperes. (b) Connected...

  1. 46 CFR 111.75-5 - Lighting branch circuits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Lighting branch circuits. 111.75-5 Section 111.75-5...-GENERAL REQUIREMENTS Lighting Circuits and Protection § 111.75-5 Lighting branch circuits. (a) Loads. A lighting distribution panel must not supply branch circuits rated at over 30 amperes. (b) Connected...

  2. 46 CFR 111.75-5 - Lighting branch circuits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Lighting branch circuits. 111.75-5 Section 111.75-5...-GENERAL REQUIREMENTS Lighting Circuits and Protection § 111.75-5 Lighting branch circuits. (a) Loads. A lighting distribution panel must not supply branch circuits rated at over 30 amperes. (b) Connected...

  3. 46 CFR 111.75-5 - Lighting branch circuits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Lighting branch circuits. 111.75-5 Section 111.75-5...-GENERAL REQUIREMENTS Lighting Circuits and Protection § 111.75-5 Lighting branch circuits. (a) Loads. A lighting distribution panel must not supply branch circuits rated at over 30 amperes. (b) Connected...

  4. 30 CFR 56.6402 - Deenergized circuits near detonators.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Deenergized circuits near detonators. 56.6402... Electric Blasting § 56.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized. Such circuits need not...

  5. LOGIC CIRCUIT

    DOEpatents

    Strong, G.H.; Faught, M.L.

    1963-12-24

    A device for safety rod counting in a nuclear reactor is described. A Wheatstone bridge circuit is adapted to prevent de-energizing the hopper coils of a ball backup system if safety rods, sufficient in total control effect, properly enter the reactor core to effect shut down. A plurality of resistances form one arm of the bridge, each resistance being associated with a particular safety rod and weighted in value according to the control effect of the particular safety rod. Switching means are used to switch each of the resistances in and out of the bridge circuit responsive to the presence of a particular safety rod in its effective position in the reactor core and responsive to the attainment of a predetermined velocity by a particular safety rod enroute to its effective position. The bridge is unbalanced in one direction during normal reactor operation prior to the generation of a scram signal and the switching means and resistances are adapted to unbalance the bridge in the opposite direction if the safety rods produce a predetermined amount of control effect in response to the scram signal. The bridge unbalance reversal is then utilized to prevent the actuation of the ball backup system, or, conversely, a failure of the safety rods to produce the predetermined effect produces no unbalance reversal and the ball backup system is actuated. (AEC)

  6. One Size Does Not Fit All: The Impact of Primary Vaccine Container Size on Vaccine Distribution and Delivery

    PubMed Central

    Haidari, Leila A.; Wahl, Brian; Brown, Shawn T.; Privor-Dumm, Lois; Wallman-Stokes, Cecily; Gorham, Katie; Connor, Diana L.; Wateska, Angela R.; Schreiber, Benjamin; Dicko, Hamadou; Jaillard, Philippe; Avella, Melanie; Lee, Bruce Y.

    2015-01-01

    BACKGROUND While the size and type of a vaccine container (i.e., primary container) can have many implications on the safety and convenience of a vaccination session, another important but potentially overlooked consideration is how the design of the primary container may affect the distribution of the vaccine, its resulting cost, and whether the vial is ultimately opened. METHODS Using our HERMES software platform, we developed a simulation model of the World Health Organization Expanded Program on Immunization supply chain for the Republic of Benin and used the model to explore the effects of different primary containers for various vaccine antigens. RESULTS Replacing vaccines with presentations containing fewer doses per vial reduced vaccine availability (proportion of people arriving for vaccines who are successfully immunized) by as much as 13% (from 73% at baseline) and raised logistics costs by up to $0.06 per dose administered (from $0.25 at baseline) due to increased bottlenecks, while reducing total costs by as much as $0.15 per dose administered (from $2.52 at baseline) due to lower open vial wastage. Primary containers with a greater number of doses per vial each improved vaccine availability by 19% and reduced logistics costs by $0.05 per dose administered, while raising the total costs by up to $0.25 per dose administered due to greater vaccine procurement needs. Changes in supply chain performance were more extreme in departments with greater constraints. Implementing a vial opening threshold reversed the direction of many of these effects. CONCLUSIONS Our results show that one size may not fit all when choosing a primary vaccine container. Rather, the choice depends on characteristics of the vaccine, the vaccine supply chain, immunization session size, and goals of decision-makers. In fact, the optimal vial size may vary among locations within a country. Simulation modeling can help identify tailored approaches to improve availability and efficiency

  7. Solidification of Liquid Distributed in its Primary Matrix Phase of Al-10Cu-Fe Alloy and Their Tribological Characteristics

    NASA Astrophysics Data System (ADS)

    Rao, L. Sankara; Jha, A. K.; Ojha, S. N.

    2016-12-01

    Solidification behavior of liquid phase entrained in its primary solid has been investigated. A hypoeutectic alloy based on Al-Cu-Fe system containing Fe and Si was thermal cycled between semisolid regions to low temperatures. The freezing characteristics of the liquid were recorded in inverse rate cooling curves. The continuous network of the liquid phase progressively changed into isolated droplets with their different size and size distribution. Such droplets revealed undercooling of the melt varying from 20 to 35 °C below the eutectic temperature of the alloy. This behavior of melt undercooling is discussed in light of independent nucleation events associated with freezing of droplets. Solidification structure of droplets revealed particulate eutectic phases in contrast to lamellar eutectic microstructure in the interdendritic region of the as-cast alloy. The droplet distribution and their solidification structure resulted in an improvement in tribological characteristics of the alloy. This effect is correlated with features of wear surfaces generated on the matting surfaces.

  8. Electrophoretic pattern and distribution of cytoskeletal proteins in flat-epitheloid and stellate process-bearing astrocytes in primary culture.

    PubMed

    Ciesielski-Treska, J; Ulrich, G; Mensch, C; Aunis, D

    1984-01-01

    One- and two-dimensional electrophoresis patterns and distribution of major cytoskeletal proteins were studied in primary astrocytes with either flat-epitheloid or stellate appearance. No major differences in the electrophoretic patterns of actin, tubulin, glial fibrillary acidic protein (GFAP) and vimentin were detected between flat-epitheloid and stellate process-bearing astrocytes produced by the exposure of cultures to dibutyryl cyclic AMP (dBcAMP). However the morphological changes of astrocytes were accompanied by marked changes in the quantitative distribution of cytoskeletal proteins. The most prominent change was a large and specific decrease in the amount of actin, detected by [(35)S]methionine incorporation, densitometric scanning of one-dimensional gels and DNase inhibition assay. In stellate astrocytes produced by a 4 day treatment with dibutyryl cyclic AMP, the amount of actin decreased by 50%. This decrease was not apparently related to the depolymerization of actin.

  9. Solidification of Liquid Distributed in its Primary Matrix Phase of Al-10Cu-Fe Alloy and Their Tribological Characteristics

    NASA Astrophysics Data System (ADS)

    Rao, L. Sankara; Jha, A. K.; Ojha, S. N.

    2017-02-01

    Solidification behavior of liquid phase entrained in its primary solid has been investigated. A hypoeutectic alloy based on Al-Cu-Fe system containing Fe and Si was thermal cycled between semisolid regions to low temperatures. The freezing characteristics of the liquid were recorded in inverse rate cooling curves. The continuous network of the liquid phase progressively changed into isolated droplets with their different size and size distribution. Such droplets revealed undercooling of the melt varying from 20 to 35 °C below the eutectic temperature of the alloy. This behavior of melt undercooling is discussed in light of independent nucleation events associated with freezing of droplets. Solidification structure of droplets revealed particulate eutectic phases in contrast to lamellar eutectic microstructure in the interdendritic region of the as-cast alloy. The droplet distribution and their solidification structure resulted in an improvement in tribological characteristics of the alloy. This effect is correlated with features of wear surfaces generated on the matting surfaces.

  10. Commutation circuit for an HVDC circuit breaker

    DOEpatents

    Premerlani, William J.

    1981-01-01

    A commutation circuit for a high voltage DC circuit breaker incorporates a resistor capacitor combination and a charging circuit connected to the main breaker, such that a commutating capacitor is discharged in opposition to the load current to force the current in an arc after breaker opening to zero to facilitate arc interruption. In a particular embodiment, a normally open commutating circuit is connected across the contacts of a main DC circuit breaker to absorb the inductive system energy trapped by breaker opening and to limit recovery voltages to a level tolerable by the commutating circuit components.

  11. Commutation circuit for an HVDC circuit breaker

    DOEpatents

    Premerlani, W.J.

    1981-11-10

    A commutation circuit for a high voltage DC circuit breaker incorporates a resistor capacitor combination and a charging circuit connected to the main breaker, such that a commutating capacitor is discharged in opposition to the load current to force the current in an arc after breaker opening to zero to facilitate arc interruption. In a particular embodiment, a normally open commutating circuit is connected across the contacts of a main DC circuit breaker to absorb the inductive system energy trapped by breaker opening and to limit recovery voltages to a level tolerable by the commutating circuit components. 13 figs.

  12. Stanniocalcin in the euryhaline flounder (Platichthys flesus): primary structure, tissue distribution, and response to altered salinity.

    PubMed

    Hang, Xiaoming; Balment, Richard John

    2005-11-01

    Stanniocalcin (STC) is a homodimeric glycoprotein hormone that was first discovered in fish, where it is largely produced by a unique endocrine gland, the corpuscles of Stannius (CS). In bony fish, it is thought to be an important regulator of calcium and phosphate uptake from the aquatic environment. This report describes the molecular cloning of STC from euryhaline flounder (Platichthys flesus) CS cDNA and genomic DNA. The flounder STC encodes a prehormone of 251 amino acids (aa) with a signal peptide of 17 aa, followed by another 15 aa sequence before the mature protein of 219 aa. The deduced aa sequence of flounder STC shows 62.9-89.0% similarity and 50.4-83.1% identity with other known fish STC sequences, but only 42.3% identity with mouse STC1, 24.4% identity with fugu and zebrafish STC2, and 22.3% identity with mouse STC2. Primary structural analysis demonstrated that flounder STC gene contains five exons in contrast to the four exons present in mammalian STC gene. RT-PCR revealed the expression of flounder STC mRNA to be widely spread in many tissues and organs, similar to the situation in mammals and other fish. Quantitative PCR (Q-PCR) was conducted to measure relative STC expression levels in the CS, which showed STC mRNA expression levels in seawater-adapted fish CS were about 3-fold higher than in freshwater-adapted fish CS.

  13. LASER APPLICATIONS AND OTHER TOPICS IN LASER TECHNOLOGY: Determination of the two-dimensional distribution of potentials in integrated circuits by the laser scanning method

    NASA Astrophysics Data System (ADS)

    Angelova, L. A.; Kravchenko, L. N.; Sagiyan, G. M.

    1988-08-01

    Experimental contactless optical measurements were made of the electrical potentials at points inside integrated circuits utilizing semiconductors exhibiting the electrooptic effect. The method developed had a voltage measurement sensitivity of 0.1 V. For the first time a two-dimensional image of the structure of a semiconductor represented by the potential contrast was obtained by the laser scanning method.

  14. Methods and theory in bone modeling drift: comparing spatial analyses of primary bone distributions in the human humerus.

    PubMed

    Maggiano, Corey M; Maggiano, Isabel S; Tiesler, Vera G; Chi-Keb, Julio R; Stout, Sam D

    2016-01-01

    This study compares two novel methods quantifying bone shaft tissue distributions, and relates observations on human humeral growth patterns for applications in anthropological and anatomical research. Microstructural variation in compact bone occurs due to developmental and mechanically adaptive circumstances that are 'recorded' by forming bone and are important for interpretations of growth, health, physical activity, adaptation, and identity in the past and present. Those interpretations hinge on a detailed understanding of the modeling process by which bones achieve their diametric shape, diaphyseal curvature, and general position relative to other elements. Bone modeling is a complex aspect of growth, potentially causing the shaft to drift transversely through formation and resorption on opposing cortices. Unfortunately, the specifics of modeling drift are largely unknown for most skeletal elements. Moreover, bone modeling has seen little quantitative methodological development compared with secondary bone processes, such as intracortical remodeling. The techniques proposed here, starburst point-count and 45° cross-polarization hand-drawn histomorphometry, permit the statistical and populational analysis of human primary tissue distributions and provide similar results despite being suitable for different applications. This analysis of a pooled archaeological and modern skeletal sample confirms the importance of extreme asymmetry in bone modeling as a major determinant of microstructural variation in diaphyses. Specifically, humeral drift is posteromedial in the human humerus, accompanied by a significant rotational trend. In general, results encourage the usage of endocortical primary bone distributions as an indicator and summary of bone modeling drift, enabling quantitative analysis by direction and proportion in other elements and populations.

  15. Country-level net primary production distribution and response to drought and land cover change.

    PubMed

    Peng, Dailiang; Zhang, Bing; Wu, Chaoyang; Huete, Alfredo R; Gonsamo, Alemu; Lei, Liping; Ponce-Campos, Guillermo E; Liu, Xinjie; Wu, Yanhong

    2017-01-01

    Carbon sequestration by terrestrial ecosystems can offset emissions and thereby offers an alternative way of achieving the target of reducing the concentration of CO2 in the atmosphere. Net primary production (NPP) is the first step in the sequestration of carbon by terrestrial ecosystems. This study quantifies moderate-resolution imaging spectroradiometer (MODIS) NPP from 2000 to 2014 at the country level along with its response to drought and land cover change. Our results indicate that the combined NPP for 53 countries represents >90% of global NPP. From 2000 to 2014, 29 of these 53 countries had increasing NPP trends, most notably the Central African Republic (23gC/m(2)/y). The top three and top 12 countries accounted for 30% and 60% of total global NPP, respectively, whereas the mean national NPP per unit area in the countries with the 12 lowest values was only around ~300gC/m(2)/y - the exception to this was Brazil, which had an NPP of 850gC/m(2)/y. Large areas of Russia, Argentina, Peru and several countries in southeast Asia showed a marked decrease in NPP (~15gC/m(2)/y). About 37% of the NPP decrease was caused by drought while ~55% of NPP variability was attributed to changes in water availability. Land cover change explained about 20% of the NPP variability. Our findings support the idea that government policies should aim primarily to improve water management in drought-afflicted countries; land use/land cover change policy could also be used as an alternative method of increasing NPP.

  16. Environmental distribution and population biology of Candidatus Accumulibacter, a primary agent of Biological Phosphorus Removal

    PubMed Central

    Peterson, S. Brook; Warnecke, Falk; Madejska, Julita; McMahon, Katherine D.; Hugenholtz, Philip

    2008-01-01

    Summary Members of the uncultured bacterial genus Candidatus Accumulibacter are capable of intracellular accumulation of inorganic phosphate (Pi) in activated sludge wastewater treatment plants (WWTPs) performing enhanced biological phosphorus removal (EBPR), but were also recently shown to inhabit freshwater and estuarine sediments. Additionally, metagenomic sequencing of two bioreactor cultures enriched in Candidatus Accumulibacter, but housed on separate continents, revealed the potential for global dispersal of particular Candidatus Accumulibacter strains, that we hypothesize is facilitated by the ability of Candidatus Accumulibacter to persist in environmental habitats. In the current study, we used sequencing of a phylogenetic marker, the ppk1 gene, to characterize Candidatus Accumulibacter populations in diverse environments, at varying distances from WWTPs. We discovered several new lineages of Candidatus Accumulibacter which had not previously been detected in WWTPs, and also uncovered new diversity and structure within previously detected lineages. Habitat characteristics were found to be a key determinant of Candidatus Accumulibacter lineage distribution, while, as predicted, geographic distance played little role in limiting dispersal on a regional scale. However, on a local scale, enrichment of particular Candidatus Accumulibacter lineages in WWTP appeared to impact local environmental populations. These results provide evidence of ecological differences among Candidatus Accumulibacter lineages. PMID:18643843

  17. Crowding alters the spatial distribution of attention modulation in human primary visual cortex.

    PubMed

    Fang, Fang; He, Sheng

    2008-07-16

    Crowding effect is the visibility reduction of a target when presented with neighboring distractors. It has been explained by either lateral inhibition at a pre-attentive level or coarse spatial resolution of attention. To test these theories, high-resolution fMRI was used to measure V1 response to the target in the presence or the absence of the distractors in both attended and unattended conditions. We found the cortical response to the target was not affected by the presence of distractors in the unattended condition. However, the spatial distribution of attention modulation in the target and its surrounding area depended on the crowding configuration. When distractors were placed in the same radial axis as the target, a configuration with a severe crowding effect, significant attention enhancements were observed not only in the target's and the distractors' locations, but also in regions next to the target where even no stimulus was presented. But this spread of attention enhancement did not occur when distractors were placed in the same circumference as the target, a configuration with a weak crowding effect. The pattern of interaction between attention and target-distractor configuration supports that crowding results from coarse spatial resolution of attention.

  18. Distribution of Root-Associated Bacterial Communities Along a Salt-Marsh Primary Succession

    PubMed Central

    Wang, Miao; Yang, Pu; Falcão Salles, Joana

    2016-01-01

    Proper quantification of the relative influence of soil and plant host on the root-associated microbiome can only be achieved by studying its distribution along an environmental gradient. Here, we used an undisturbed salt marsh chronosequence to study the bacterial communities associated with the soil, rhizosphere and the root endopshere of Limonium vulgare using 454-pyrosequencing. We hypothesize that the selective force exerted by plants rather than soil would regulate the dynamics of the root-associated bacterial assembly along the chronosequence. Our results showed that the soil and rhizosphere bacterial communities were phylogenetically more diverse than those in the endosphere. Moreover, the diversity of the rhizosphere microbiome followed the increased complexity of the abiotic and biotic factors during succession while remaining constant in the other microbiomes. Multivariate analyses showed that the rhizosphere and soil-associated communities clustered by successional stages, whereas the endosphere communities were dispersed. Interestingly, the endosphere microbiome showed higher turnover, while the bulk and rhizosphere soil microbiomes became more similar at the end of the succession. Overall, we showed that soil characteristics exerted an overriding influence on the rhizosphere microbiome, although plant effect led to a clear diversity pattern along the succession. Conversely, the endosphere microbiome was barely affected by any of the environmental measurements and very distinct from other communities. PMID:26779222

  19. Patterns of distribution of inorganic nutrients in Red Sea and their implications to primary production

    NASA Astrophysics Data System (ADS)

    Wafar, Mohideen; Qurban, Mohammad Ali; Ashraf, Mohamed; Manikandan, K. P.; Flandez, Ace Vincent; Balala, Arvin C.

    2016-04-01

    This paper presents data on inorganic nutrients obtained in several transects within Saudi Arabian waters of the Red Sea in 2012-2015. Increase in their concentrations from north to south is not monotonously linear but is punctuated by regions of high concentrations alternating with those of low concentrations, regardless of the type of nutrient (N, P or Si), season and location. Such a type of distribution could be only explained in terms of eddy circulations within the Red Sea basin. The enrichment with nutrients of the boundary currents of the eddies could be explained partly by entrainment of Gulf of Aden Intermediate Water in the eddies and the mixing of the latter with the underlying Red Sea Deep Water, and partly by a higher biological productivity in the peripheries of the eddies. These results have two major implications for our understanding of biogeochemical cycles in the Red Sea. The first is that the eddy-associated injection of nutrients into the euphotic zone could cause higher levels of production over a substantial spread of the Red Sea. The second is that the anticyclonic eddies may function as traps of nutrients and in that event, their peripheries and centers may function as independent mesocosms.

  20. Circuit monitors powerline interruptions

    NASA Technical Reports Server (NTRS)

    Simmons, N. E.; Stricklen, J. O.

    1977-01-01

    Simple circuit when combined with pulse detector detects momentary interruptions of 400-cycle ac signal. Circuit has been used during shock and vibration testing of electronic hardware to determine if tests caused interruptions of normal circuit operation.

  1. A simple tachometer circuit

    NASA Technical Reports Server (NTRS)

    Dimeff, J.

    1972-01-01

    Electric circuit to measure frequency of repetitive sinusoidal or rectangular wave is presented. Components of electric circuit and method of operation are explained. Application of circuit as tachometer for automobile is discussed.

  2. Novel circuit theory of Andreev reflection

    NASA Astrophysics Data System (ADS)

    Nazarov, Yuli V.

    1999-05-01

    We review here a novel circuit theory of superconductivity. The existing circuit theory of Andreev reflection has been revised to account for decoherence between electrons and holes and the twofold nature of the distribution function. The description of arbitrary connectors has been elaborated on. In this way one can cope with most of the factors that limited the applicability of the old circuit theory. We give a simple example and discuss numerical implementation of the theory.

  3. Primary Accretion and Turbulent Cascades: Scale-Dependence of Particle Concentration Multiplier Probability Distribution Functions

    NASA Astrophysics Data System (ADS)

    Cuzzi, Jeffrey N.; Weston, B.; Shariff, K.

    2013-10-01

    Primitive bodies with 10s-100s of km diameter (or even larger) may form directly from small nebula constituents, bypassing the step-by-step “incremental growth” that faces a variety of barriers at cm, m, and even 1-10km sizes. In the scenario of Cuzzi et al (Icarus 2010 and LPSC 2012; see also Chambers Icarus 2010) the immediate precursors of 10-100km diameter asteroid formation are dense clumps of chondrule-(mm-) size objects. These predictions utilize a so-called cascade model, which is popular in turbulence studies. One of its usual assumptions is that certain statistical properties of the process (the so-called multiplier pdfs p(m)) are scale-independent within a cascade of energy from large eddy scales to smaller scales. In similar analyses, Pan et al (2011 ApJ) found discrepancies with results of Cuzzi and coworkers; one possibility was that p(m) for particle concentration is not scale-independent. To assess the situation we have analyzed recent 3D direct numerical simulations of particles in turbulence covering a much wider range of scales than analyzed by either Cuzzi and coworkers or by Pan and coworkers (see Bec et al 2010, J. Flu. Mech 646, 527). We calculated p(m) at scales ranging from 45-1024η where η is the Kolmogorov scale, for both particles with a range of stopping times spanning the optimum value, and for energy dissipation in the fluid. For comparison, the p(m) for dissipation have been observed to be scale-independent in atmospheric flows (at much larger Reynolds number) for scales of at least 30-3000η. We found that, in the numerical simulations, the multiplier distributions for both particle concentration and fluid dissipation are as expected at scales of tens of η, but both become narrower and less intermittent at larger scales. This is consistent with observations of atmospheric flows showing scale independence to >3000η if scale-free behavior is established only after some number 10 of large-scale bifurcations (at scales perhaps

  4. Distribution, persistence and interchange of Epstein-Barr virus strains among PBMC, plasma and saliva of primary infection subjects.

    PubMed

    Kwok, Hin; Chan, Koon Wing; Chan, Kwok Hung; Chiang, Alan Kwok Shing

    2015-01-01

    Our study aimed at investigating the distribution, persistence and interchange of viral strains among peripheral blood mononuclear cells (PBMC), plasma and saliva of primary Epstein-Barr virus (EBV) infection subjects. Twelve infectious mononucleosis (IM) patients and eight asymptomatic individuals (AS) with primary EBV infection were followed longitudinally at several time points for one year from the time of diagnosis, when blood and saliva samples were collected and separated into PBMC, plasma and saliva, representing circulating B cell, plasma and epithelial cell compartments, respectively. To survey the viral strains, genotyping assays for the natural polymorphisms in two latent EBV genes, EBNA2 and LMP1, were performed and consisted of real-time PCR on EBNA2 to distinguish type 1 and 2 viruses, fluorescent-based 30-bp typing assay on LMP1 to distinguish deletion and wild type LMP1, and fluorescent-based heteroduplex tracking assays on both EBNA2 and LMP1 to distinguish defined polymorphic variants. No discernible differences were observed between IM patients and AS. Multiple viral strains were acquired early at the start of infection. Stable persistence of dominant EBV strains in the same tissue compartment was observed throughout the longitudinal samples. LMP1-defined strains, China 1, China 2 and Mediterranean+, were the most common strains observed. EBNA2-defined groups 1 and 3e predominated the PBMC and saliva compartments. Concordance of EBNA2 and LMP1 strains between PBMC and saliva suggested ready interchange of viruses between circulating B cell and epithelial cell pools, whilst discordance of viral strains observed between plasma and PBMC/saliva indicated presence of viral pools in other undetermined tissue compartments. Taken together, the results indicated that the distribution, persistence and interchange of viral strains among the tissue compartments are more complex than those proposed by the current model of EBV life cycle.

  5. Incongruence between primary sequence data and the distribution of a mitochondrial atp1 group II intron among ferns and horsetails.

    PubMed

    Wikström, Niklas; Pryer, Kathleen M

    2005-09-01

    Using DNA sequence data from multiple genes (often from more than one genome compartment) to reconstruct phylogenetic relationships has become routine. Augmenting this approach with genomic structural characters (e.g., intron gain and loss, changes in gene order) as these data become available from comparative studies already has provided critical insight into some long-standing questions about the evolution of land plants. Here we report on the presence of a group II intron located in the mitochondrial atp1 gene of leptosporangiate and marattioid ferns. Primary sequence data for the atp1 gene are newly reported for 27 taxa, and results are presented from maximum likelihood-based phylogenetic analyses using Bayesian inference for 34 land plants in three data sets: (1) single-gene mitochondrial atp1 (exon+intron sequences); (2) five combined genes (mitochondrial atp1 [exon only]; plastid rbcL, atpB, rps4; nuclear SSU rDNA); and (3) same five combined genes plus morphology. All our phylogenetic analyses corroborate results from previous fern studies that used plastid and nuclear sequence data: the monophyly of euphyllophytes, as well as of monilophytes; whisk ferns (Psilotidae) sister to ophioglossoid ferns (Ophioglossidae); horsetails (Equisetopsida) sister to marattioid ferns (Marattiidae), which together are sister to the monophyletic leptosporangiate ferns. In contrast to the results from the primary sequence data, the genomic structural data (atp1 intron distribution pattern) would seem to suggest that leptosporangiate and marattioid ferns are monophyletic, and together they are the sister group to horsetails--a topology that is rarely reconstructed using primary sequence data.

  6. Establishment of a primary hepatocyte culture from the small Indian mongoose (Herpestes auropunctatus) and distribution of mercury in liver tissue.

    PubMed

    Horai, Sawako; Yanagi, Kumiko; Kaname, Tadashi; Yamamoto, Masatatsu; Watanabe, Izumi; Ogura, Go; Abe, Shintaro; Tanabe, Shinsuke; Furukawa, Tatsuhiko

    2014-11-01

    The present study established a primary hepatocyte culture for the small Indian mongoose (Herpestes auropunctatus). To determine the suitable medium for growing the primary hepatic cells of this species, we compared the condition of cells cultured in three media that are frequently used for mammalian cell culture: Dulbecco's Modified Eagle's Medium, RPMI-1640, and William's E. Of these, William's E medium was best suited for culturing the hepatic cells of this species. Using periodic acid-Schiff staining and ultrastructural observations, we demonstrated the cells collected from mongoose livers were hepatocytes. To evaluate the distribution of mercury (Hg) in the liver tissue, we carried out autometallography staining. Most of the Hg compounds were found in the central region of hepatic lobules. Smooth endoplasmic reticulum, which plays a role inxenobiotic metabolism, lipid/cholesterol metabolism, and the digestion and detoxification of lipophilic substances is grown in this area. This suggested that Hg colocalized with smooth endoplasmic reticulum. The results of the present study could be useful to identify the detoxification systems of wildlife with high Hg content in the body, and to evaluate the susceptibility of wildlife to Hg toxicity.

  7. The Composition of Comet C/2012 K1 (PanSTARRS) and the Distribution of Primary Volatile Abundances among Comets

    NASA Astrophysics Data System (ADS)

    Roth, Nathan X.; Gibb, Erika L.; Bonev, Boncho P.; DiSanti, Michael A.; Mumma, Michael J.; Villanueva, Geronimo L.; Paganini, Lucas

    2017-04-01

    On 2014 May 22 and 24 we characterized the volatile composition of the dynamically new Oort cloud comet C/2012 K1 (PanSTARRS) using the long-slit, high resolution (λ/Δλ ≈ 25,000) near-infrared echelle spectrograph (NIRSPEC) at the 10 m Keck II telescope on Maunakea, Hawaii. We detected fluorescent emission from six primary volatiles (H2O, HCN, CH4, C2H6, CH3OH, and CO). Upper limits were derived for C2H2, NH3, and H2CO. We report rotational temperatures, production rates, and mixing ratios (relative to water). Compared with median abundance ratios for primary volatiles in other sampled Oort cloud comets, trace gas abundance ratios in C/2012 K1 (PanSTARRS) for CO and HCN are consistent, but CH3OH and C2H6 are enriched while H2CO, CH4, and possibly C2H2 are depleted. When placed in context with comets observed in the near-infrared to date, the data suggest a continuous distribution of abundances of some organic volatiles (HCN, C2H6, CH3OH, CH4) among the comet population. The level of “enrichment” or “depletion” in a given comet does not necessarily correlate across all molecules sampled, suggesting that chemical diversity among comets may be more complex than the simple organics-enriched, organics-normal, and organics-depleted framework.

  8. Primary distribution of silver and copper in native gold from six deposits in the Western United States

    USGS Publications Warehouse

    Desborough, G.A.; Heidel, R.H.; Raymond, W.H.; Tripp, J.

    1971-01-01

    Electron-microprobe analyses and mineragraphic studies of native gold demonstrate considerable variations in the primary intergrain and intragrain distribution of silver. The gold grains have from 1-55 weight percent silver; copper is present in grains from only one locality and ranges from 0.1-0.6 weight percent. Some gold grains have strong zoning of silver whereas others have no detectable zoning. Gold grains from some deposits show remarkable intergrain homogeneity of silver and/or copper content, but others exhibit extreme heterogeneity. We believe that the inhomogeneities and variations in silver content recognized and emphasized here are features of primary deposition. We also recognize low-silver rims with sharp boundaries bordering many of the grains examined but believe these are developed in a relatively oxidizing, low-temperature environment and are not primary lode features. Opaque mineral inclusions of primary origin in gold grains are common in some deposits, scarce in many, and virtually absent from others. These inclusions may be of value in characterizing some gold deposits. For the majority of gold crystals from Copper Basin, Arizona, the lowest silver content observed was in the central portion of each grain and the highest silver content was in the rim. This is believed to be due an increase in the proportion of silver to gold in solution during growth of the crystals. Analysis of sized fractions of 331 gold grains from Pennsylvania Mountain, Colorado, shows no systematic correlation of grain size with silver content. Electron microprobe step-scanning of gold from Alder Gulch, Montana, suggests more than one mineralization event took place. Pyrite and acanthite inclusions less than 0.05 mm in the largest dimension, are present in some grains from this deposit. Inclusions of pyrite, pyrrhotite, chalcopyrite, and an isotropic Co-As-S mineral are present in the low-silver, copper-bearing gold from Ninemile Creek, Montana. The presence of copper

  9. Carbon distribution and aboveground net primary production in aspen, jack pine, and black spruce stands in Saskatchewan and Manitoba, Canada

    NASA Astrophysics Data System (ADS)

    Gower, S. T.; Vogel, J. G.; Norman, J. M.; Kucharik, C. J.; Steele, S. J.; Stow, T. K.

    1997-12-01

    The objectives of this study are to (1) characterize the carbon (C) content, leaf area index, and aboveground net primary production (ANPP) for mature aspen, black spruce, and young and mature jack pine stands at the southern and northern Boreal Ecosystem-Atmosphere Study (BOREAS) areas and (2) compare net primary production and carbon allocation coefficients for the major boreal forest types of the world. Direct estimates of leaf area index, defined as one half of the total leaf surface area, range from a minimum of 1.8 for jack pine forests to a maximum of 5.6 for black spruce forests; stems comprise 5 to 15% of the total overstory plant area. In the BOREAS study, total ecosystem (vegetation plus detritus plus soil) carbon content is greatest in the black spruce forests (445,760-479,380 kg C ha-1), with 87 to 88% of the C in the soil, and is lowest in the jack pine stands (68,370-68,980 kg C ha-1) with a similar distribution of carbon in the vegetation and soil. Forest floor carbon content and mean residence time (MRT) also vary more among forest types in a study area than between study areas for a forest type; forest floor MRT range from 16 to 19 years for aspen stands to 28 to 39 years for jack pine stands. ANPP differs significantly among the mature forests at each of the BOREAS study areas, ranging from a maximum of 3490 to 3520 kg C ha-1 yr-1 for aspen stands to 1170 to 1220 kg C ha-1 yr-1 for jack pine stands. Both net primary production (NPP) and carbon allocation differ between boreal evergreen and deciduous forests in the world, suggesting global primary production models should distinguish between these two forest types. On average, 56% of NPP for boreal forests occurs as detritus and illustrates the need to better understand factors controlling aboveground and below-ground detritus production in boreal forests.

  10. Simple Autonomous Chaotic Circuits

    NASA Astrophysics Data System (ADS)

    Piper, Jessica; Sprott, J.

    2010-03-01

    Over the last several decades, numerous electronic circuits exhibiting chaos have been proposed. Non-autonomous circuits with as few as two components have been developed. However, the operation of such circuits relies on the non-ideal behavior of the devices used, and therefore the circuit equations can be quite complex. In this paper, we present two simple autonomous chaotic circuits using only opamps and linear passive components. The circuits each use one opamp as a comparator, to provide a signum nonlinearity. The chaotic behavior is robust, and independent of nonlinearities in the passive components. Moreover, the circuit equations are among the algebraically simplest chaotic systems yet constructed.

  11. Solenoid-Simulation Circuit

    NASA Technical Reports Server (NTRS)

    Simon, R. A.

    1986-01-01

    Electrical properties of solenoids imitated for tests of control circuits. Simulation circuit imitates voltage and current responses of two engine-controlling solenoids. Used in tests of programs of digital engine-control circuits, also provides electronic interface with circuits imitating electrical properties of pressure sensors and linear variable-differential transformers. Produces voltages, currents, delays, and discrete turnon and turnoff signals representing operation of solenoid in engine-control relay. Many such circuits used simulating overall engine circuitry.

  12. Algal pigment distribution and primary production in the eastern Mediterranean as derived from coastal zone color scanner observations

    NASA Astrophysics Data System (ADS)

    Antoine, David; Morel, André; André, Jean-Michel

    1995-08-01

    About 300 coastal zone color scanner (CZCS) scenes, gathered over the eastern Mediterranean basin mostly during the years 1979-1981, have been processed from level 1 by using improved pixel-by-pixel procedures for the atmospheric correction and pigment retrieval. The seasonal evolution of the upper ocean pigment concentration is described and analyzed within the whole basin and its subbasins. From the chlorophyll concentration in the top layer, and by using statistical relationships, the depth-integrated pigment content is estimated and used in conjunction with a light-photosynthesis model to estimate the carbon fixation. The model relies on a set of physiological parameters, selected after the validation of the light-photosynthesis model and not on locally measured parameters. Additional information needed in the modeling are the photosynthetically available radiation (computed from astronomic and atmospheric parameters, combined with a cloud climatology), sea temperature and mixed-layer depth (taken from Levitus (1982)). Actually, the model is used to generate look-up tables in such a way that all possible situations (concerning available radiation, chlorophyll concentration, and temperature) are covered. The appropriate situation associated with any pixel is selected from these tables to generate primary production maps. Despite a relatively good spatial coverage, studying the interannual variability of the pigment distribution and primary production appeared to be impossible. Therefore 12 "climatological" monthly chlorophyll maps have been produced by merging the data corresponding to several years. The carbon fixation rates in each of the subbasins have been computed on a monthly basis, and annual mean values derived thereafter. The primary production values are compared with sparse field determinations. They are also compared with those previously derived for the Western basin, also by using CZCS data (Morel and André, 1991). When put together, these

  13. PAD-MAC: Primary User Activity-Aware Distributed MAC for Multi-Channel Cognitive Radio Networks

    PubMed Central

    Ali, Amjad; Piran, Md. Jalil; Kim, Hansoo; Yun, Jihyeok; Suh, Doug Young

    2015-01-01

    Cognitive radio (CR) has emerged as a promising technology to solve problems related to spectrum scarcity and provides a ubiquitous wireless access environment. CR-enabled secondary users (SUs) exploit spectrum white spaces opportunistically and immediately vacate the acquired licensed channels as primary users (PUs) arrive. Accessing the licensed channels without the prior knowledge of PU traffic patterns causes severe throughput degradation due to excessive channel switching and PU-to-SU collisions. Therefore, it is significantly important to design a PU activity-aware medium access control (MAC) protocol for cognitive radio networks (CRNs). In this paper, we first propose a licensed channel usage pattern identification scheme, based on a two-state Markov model, and then estimate the future idle slots using previous observations of the channels. Furthermore, based on these past observations, we compute the rank of each available licensed channel that gives SU transmission success assessment during the estimated idle slot. Secondly, we propose a PU activity-aware distributed MAC (PAD-MAC) protocol for heterogeneous multi-channel CRNs that selects the best channel for each SU to enhance its throughput. PAD-MAC controls SU activities by allowing them to exploit the licensed channels only for the duration of estimated idle slots and enables predictive and fast channel switching. To evaluate the performance of the proposed PAD-MAC, we compare it with the distributed QoS-aware MAC (QC-MAC) and listen-before-talk MAC schemes. Extensive numerical results show the significant improvements of the PAD-MAC in terms of the SU throughput, SU channel switching rate and PU-to-SU collision rate. PMID:25831084

  14. Hidden circuits and argumentation

    NASA Astrophysics Data System (ADS)

    Leinonen, Risto; Kesonen, Mikko H. P.; Hirvonen, Pekka E.

    2016-11-01

    Despite the relevance of DC circuits in everyday life and schools, they have been shown to cause numerous learning difficulties at various school levels. In the course of this article, we present a flexible method for teaching DC circuits at lower secondary level. The method is labelled as hidden circuits, and the essential idea underlying hidden circuits is in hiding the actual wiring of DC circuits, but to make their behaviour evident for pupils. Pupils are expected to find out the wiring of the circuit which should enhance their learning of DC circuits. We present two possible ways to utilise hidden circuits in a classroom. First, they can be used to test and enhance pupils’ conceptual understanding when pupils are expected to find out which one of the offered circuit diagram options corresponds to the actual circuit shown. This method aims to get pupils to evaluate the circuits holistically rather than locally, and as a part of that aim this method highlights any learning difficulties of pupils. Second, hidden circuits can be used to enhance pupils’ argumentation skills with the aid of argumentation sheet that illustrates the main elements of an argument. Based on the findings from our co-operating teachers and our own experiences, hidden circuits offer a flexible and motivating way to supplement teaching of DC circuits.

  15. [Profile distribution of soil aggregates organic carbon in primary forests in Karst cluster-peak depression region].

    PubMed

    Lu, Ling-Xiao; Song, Tong-Qing; Peng, Wan-Xia; Zeng, Fu-Ping; Wang, Ke-Lin; Xu, Yun-Lei; Yu, Zi; Liu, Yan

    2012-05-01

    Soil profiles were collected from three primary forests (Itoa orientalis, Platycladus orientalis, and Radermachera sinica) in Karst cluster-peak depression region to study the composition of soil aggregates, their organic carbon contents, and the profile distribution of the organic carbon. In the three forests, >2 mm soil aggregates were dominant, occupying about 76% of the total. The content of soil total organic carbon ranged from 12.73 to 68.66 g x kg(-1), with a significant difference among the forests. The organic carbon content in <1 mm soil aggregates was slightly higher than that in >2 mm soil aggregates, but most of soil organic carbon was stored in the soil aggregates with greater particle sizes. About 70% of soil organic carbon came from >2 mm soil aggregates. There was a significant positive relationship between the contents of 2-5 and 5-8 mm soil aggregates and the content of soil organic carbon. To increase the contents of 2-8 mm soil aggregates could effectively improve the soil carbon sequestration in Karst region. In Itoa orientalis forest, 2-8 mm soil aggregates accounted for 46% of the total, and the content of soil total organic carbon reached to 37.62 g x kg(-1), which implied that Itoa orientalis could be the suitable tree species for the ecological restoration in Karst region.

  16. Normal development of brain circuits.

    PubMed

    Tau, Gregory Z; Peterson, Bradley S

    2010-01-01

    Spanning functions from the simplest reflex arc to complex cognitive processes, neural circuits have diverse functional roles. In the cerebral cortex, functional domains such as visual processing, attention, memory, and cognitive control rely on the development of distinct yet interconnected sets of anatomically distributed cortical and subcortical regions. The developmental organization of these circuits is a remarkably complex process that is influenced by genetic predispositions, environmental events, and neuroplastic responses to experiential demand that modulates connectivity and communication among neurons, within individual brain regions and circuits, and across neural pathways. Recent advances in neuroimaging and computational neurobiology, together with traditional investigational approaches such as histological studies and cellular and molecular biology, have been invaluable in improving our understanding of these developmental processes in humans in both health and illness. To contextualize the developmental origins of a wide array of neuropsychiatric illnesses, this review describes the development and maturation of neural circuits from the first synapse through critical periods of vulnerability and opportunity to the emergent capacity for cognitive and behavioral regulation, and finally the dynamic interplay across levels of circuit organization and developmental epochs.

  17. 30 CFR 57.6402 - Deenergized circuits near detonators.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Deenergized circuits near detonators. 57.6402... Electric Blasting-Surface and Underground § 57.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized....

  18. Electrical Circuits and Water Analogies

    ERIC Educational Resources Information Center

    Smith, Frederick A.; Wilson, Jerry D.

    1974-01-01

    Briefly describes water analogies for electrical circuits and presents plans for the construction of apparatus to demonstrate these analogies. Demonstrations include series circuits, parallel circuits, and capacitors. (GS)

  19. Linear integrated circuits

    NASA Astrophysics Data System (ADS)

    Young, T.

    This book is intended to be used as a textbook in a one-semester course at a variety of levels. Because of self-study features incorporated, it may also be used by practicing electronic engineers as a formal and thorough introduction to the subject. The distinction between linear and digital integrated circuits is discussed, taking into account digital and linear signal characteristics, linear and digital integrated circuit characteristics, the definitions for linear and digital circuits, applications of digital and linear integrated circuits, aspects of fabrication, packaging, and classification and numbering. Operational amplifiers are considered along with linear integrated circuit (LIC) power requirements and power supplies, voltage and current regulators, linear amplifiers, linear integrated circuit oscillators, wave-shaping circuits, active filters, DA and AD converters, demodulators, comparators, instrument amplifiers, current difference amplifiers, analog circuits and devices, and aspects of troubleshooting.

  20. Sense circuit arrangement

    NASA Technical Reports Server (NTRS)

    Bohning, Oliver D. (Inventor)

    1976-01-01

    A unique, two-node sense circuit is disclosed. The circuit includes a bridge comprised of resistance elements and a differential amplifier. The two-node circuit is suitably adapted to be arranged in an array comprised of a plurality of discrete bridge-amplifiers which can be selectively energized. The circuit is arranged so as to form a configuration with minimum power utilization and a reduced number of components and interconnections therebetween.

  1. Piezoelectric drive circuit

    DOEpatents

    Treu, C.A. Jr.

    1999-08-31

    A piezoelectric motor drive circuit is provided which utilizes the piezoelectric elements as oscillators and a Meacham half-bridge approach to develop feedback from the motor ground circuit to produce a signal to drive amplifiers to power the motor. The circuit automatically compensates for shifts in harmonic frequency of the piezoelectric elements due to pressure and temperature changes. 7 figs.

  2. Piezoelectric drive circuit

    DOEpatents

    Treu, Jr., Charles A.

    1999-08-31

    A piezoelectric motor drive circuit is provided which utilizes the piezoelectric elements as oscillators and a Meacham half-bridge approach to develop feedback from the motor ground circuit to produce a signal to drive amplifiers to power the motor. The circuit automatically compensates for shifts in harmonic frequency of the piezoelectric elements due to pressure and temperature changes.

  3. Genealogy of Chua's Circuit

    NASA Astrophysics Data System (ADS)

    Kennedy, Peter

    2013-01-01

    Since its invention in 1983, Chua's circuit has become a reference circuit for studying bifurcations and chaos. This chapter plots the evolution of the circuit from the original simulations and experimental realization of a five-element topology with a three-segment nonlinear resistor to the latest three-element design comprising a capacitor, an inductor, and a memristor.

  4. Integrated Circuit Computer Analysis.

    DTIC Science & Technology

    information on this topic. The most important findings were the method used to identify combinational circuits ( Quine - McCluskey algorithm) and a clearly...defined set of limits on the problem of identifying sequential circuits. Since the Quine - McCluskey algorithm works only for combinational circuits, an

  5. CIRCUITS FOR CURRENT MEASUREMENTS

    DOEpatents

    Cox, R.J.

    1958-11-01

    Circuits are presented for measurement of a logarithmic scale of current flowing in a high impedance. In one form of the invention the disclosed circuit is in combination with an ionization chamber to measure lonization current. The particular circuit arrangement lncludes a vacuum tube having at least one grid, an ionization chamber connected in series with a high voltage source and the grid of the vacuum tube, and a d-c amplifier feedback circuit. As the ionization chamber current passes between the grid and cathode of the tube, the feedback circuit acts to stabilize the anode current, and the feedback voltage is a measure of the logaritbm of the ionization current.

  6. Seasonal distribution of net primary production by functional groups in Chihuahuan Desert, and the role of seasonal precipitation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In hot deserts, precipitation is the principal driver for net primary production.  This study tested two hypotheses regarding aboveground net primary production (ANPP) and the effects of precipitation on ANPP in the Chihuahuan Desert, with emphasis on differences among seasons and among functional g...

  7. Single event upset protection circuit and method

    DOEpatents

    Wallner, John; Gorder, Michael

    2016-03-22

    An SEU protection circuit comprises first and second storage means for receiving primary and redundant versions, respectively, of an n-bit wide data value that is to be corrected in case of an SEU occurrence; the correction circuit requires that the data value be a 1-hot encoded value. A parity engine performs a parity operation on the n bits of the primary data value. A multiplexer receives the primary and redundant data values and the parity engine output at respective inputs, and is arranged to pass the primary data value to an output when the parity engine output indicates `odd` parity, and to pass the redundant data value to the output when the parity engine output indicates `even` parity. The primary and redundant data values are suitably state variables, and the parity engine is preferably an n-bit wide XOR or XNOR gate.

  8. Modeling the transport of nitrogen in an NPP-2006 reactor circuit

    NASA Astrophysics Data System (ADS)

    Stepanov, O. E.; Galkin, I. Yu.; Sledkov, R. M.; Melekh, S. S.; Strebnev, N. A.

    2016-07-01

    Efficient radiation protection of the public and personnel requires detecting an accident-initiating event quickly. Specifically, if a heat-exchange tube in a steam generator is ruptured, the 16N radioactive nitrogen isotope, which contributes to a sharp increase in the steam activity before the turbine, may serve as the signaling component. This isotope is produced in the core coolant and is transported along the circulation circuit. The aim of the present study was to model the transport of 16N in the primary and the secondary circuits of a VVER-1000 reactor facility (RF) under nominal operation conditions. KORSAR/GP and RELAP5/Mod.3.2 codes were used to perform the calculations. Computational models incorporating the major components of the primary and the secondary circuits of an NPP-2006 RF were constructed. These computational models were subjected to cross-verification, and the calculation results were compared to the experimental data on the distribution of the void fraction over the steam generator height. The models were proven to be valid. It was found that the time of nitrogen transport from the core to the heat-exchange tube leak was no longer than 1 s under RF operation at a power level of 100% N nom with all primary circuit pumps activated. The time of nitrogen transport from the leak to the γ-radiation detection unit under the same operating conditions was no longer than 9 s, and the nitrogen concentration in steam was no less than 1.4% (by mass) of its concentration at the reactor outlet. These values were obtained using conservative approaches to estimating the leak flow and the transport time, but the radioactive decay of nitrogen was not taken into account. Further research concerned with the calculation of thermohydraulic processes should be focused on modeling the transport of nitrogen under RF operation with some primary circuit pumps deactivated.

  9. The Distribution and the Fibrotic Role of Elevated Inflammatory Th17 Cells in Patients With Primary Biliary Cirrhosis.

    PubMed

    Shi, TianYan; Zhang, Ting; Zhang, LiNa; Yang, YunJiao; Zhang, HaoZe; Zhang, FengChun

    2015-11-01

    T helper (Th) 17 cells were reported to have the property of proinflammation and profibrosis. We first investigate the levels of Th17 cells in primary biliary cirrhosis (PBC) patients, and then explore their distribution and fibrotic role in the disease.We compared the circulating Th17 and hepatic interleukin (IL)-17-positive cells between patients and healthy controls (HCs) at different disease stages by flow cytometry and immunohistochemistry, respectively. The levels of chemokine (c-c motif) ligand (CCL) 20 were then measured. For exploration of the reason why Th17 cells increased, CD4CD161 populations were sorted and cultured with IL-23 and IL-1β to analyze their proliferation and IL-17 secretions. The serum IL-23 and IL-1β were tested by enzyme-linked immunosorbent assay. The proliferation and expressions of α-smooth muscle actin and IL-8 of hepatic stellate cells (HSCs) were identified after stimulated by different concentrations of IL-17.Circulating and hepatic Th17 cells were elevated in PBC patients compared with HCs. Early PBC patients presented with more Th17 cells in periphery blood and less in the liver than advanced PBC patients. Accordingly, the levels of both serum and hepatic CCL20 for Th17 cells were higher, especially in those with advanced disease. The progenitor of Th17, CD4CD161 cell was increased in PBC. Moreover, the percentage of Th17 cells was positively related with CD4CD161 cell. After stimulation with IL-23 and IL-1β which were improved in PBC patients, CD4CD161 cells from PBC patients expressed more IL-17, although their proliferation were not different between 2 groups. IL-17 can promote the proliferation of HSCs at a dose-dependent method, and also increase the IL-8 expression in a dose/time-dependent way. Anti-IL-17 can neutralize the above reactions.CD4CD161 cells are a source of increased Th17 in PBC patients. With disease progression, Th17 population decreased in the circulation, accompanied by greater accumulation in the

  10. Feline hyperthyroidism reported in primary-care veterinary practices in England: prevalence, associated factors and spatial distribution.

    PubMed

    Stephens, M J; O'Neill, D G; Church, D B; McGreevy, P D; Thomson, P C; Brodbelt, D C

    2014-11-08

    Feline hyperthyroidism is a commonly diagnosed endocrinopathy that can have a substantial deleterious impact on the welfare of affected cats. This study aimed to estimate the prevalence, associated factors and geographical distribution for feline hyperthyroidism in England, using primary-care veterinary practice clinical data from the VetCompass Animal Surveillance Project. Prevalence was estimated from the overall cat cohort. Associated factor analysis used an age-matched, nested, case-control design with multivariable logistic regression. There were 2,276 cases of feline hyperthyroidism identified from 95,629 cats attending 84 practices from September 2009 to December 2011. Cases were aged 6-25 years. 3.7 per cent of cases and 9.9 per cent of controls were purebred, 56.4 per cent of cases and 56.5 per cent of controls were female, and 88.1 per cent of cases and 86.0 per cent of controls were neutered. The apparent prevalence was 2.4 per cent (95% CI 2.3 to 2.5 per cent) overall, and 8.7 per cent (95% CI 8.3 to 9.0 per cent) in cats aged 10 years or above. Burmese (OR 0.15, 95% CI 0.07 to 0.32, P<0.0001), Persian (OR 0.17, 95% CI 0.08 to 0.33, P<0.0001), Siamese (OR 0.4, 95% CI 0.21 to 0.75, P=0.004) and purebred cats overall (OR 0.33, 95% CI 0.25 to 0.42, P< 0.0001) had lower odds of feline hyperthyroidism than non-purebred cats. Insured cats had increased odds (OR 1.78, 95% CI 1.56 to 2.03, P< 0.001). There was little evidence of spatial variation. This study highlights feline hyperthyroidism as a high-prevalence disease in England, and reports reduced odds of diagnosis in certain breeds and purebred cats overall.

  11. Red Blood Cell Distribution Width to Platelet Ratio is Related to Histologic Severity of Primary Biliary Cirrhosis

    PubMed Central

    Wang, Huan; Xu, Hongqin; Wang, Xiaomei; Wu, Ruihong; Gao, Xiuzhu; Jin, Qinglong; Niu, Junqi

    2016-01-01

    Abstract We aimed to investigate whether red blood cell distribution width (RDW) and RDW to platelet ratio (RPR) were related to the histologic severity of primary biliary cirrhosis (PBC). Seventy-three treatment-naïve PBC patients who had undergone a liver biopsy between January 2010 and January 2015 were enrolled in our study. The patients’ histological stages were based on the classifications of Ludwig and Scheuer. The patients were divided into early stage (Stage I) and advanced stage (Stage II, III, and IV) hepatic fibrosis according to their histological stage. All common patient demographics, clinical characteristics, hematological parameters, liver biochemistry, and antimitochondrial M2 antibody levels (AMA-M2) were retrospectively analyzed, and RDW, RPR, aspartate aminotransferase-to-platelet ratio index (APRI), and fibrosis index based on the 4 factors (FIB-4) were calculated. A total of 28 (38.4%) patients had early stage PBC, whereas 45 (62.6%) were classified as advanced stage. Regarding age, no significant differences between the early and advanced stages were observed. Patients with advanced stage PBC had significantly higher RDW (13.6 vs 14.4; P = 0.019), conjugated bilirubin (10.1 vs 23.4; P = 0.029), and significantly lower cholinesterase (7901.1 vs 6060.8; P = 0.001) and platelets (212.6 vs 167.0; P = 0.006). However, no significant differences (P > 0.05) in other routine parameters previously evaluated in PBC, including aspartate aminotransferase (AST) and mean platelet volume, were found between the groups. The sensitivity and specificity of RDW were 33.3% and 92.9%, respectively, and the area under the receiver-operating characteristic curve (AUROC) was 0.66. However, the sensitivity and specificity of RPR were 46.7% and 96.4%, respectively, and the corresponding AUROC was 0.74 (P < 0.001). Hence, compared with preexisting indicators, RPR showed a higher AUROC than APRI (0.648; P = 0.035) and FIB-4 (0.682; P

  12. The Distribution and the Fibrotic Role of Elevated Inflammatory Th17 Cells in Patients With Primary Biliary Cirrhosis

    PubMed Central

    Shi, TianYan; Zhang, Ting; Zhang, LiNa; Yang, YunJiao; Zhang, HaoZe; Zhang, FengChun

    2015-01-01

    Abstract T helper (Th) 17 cells were reported to have the property of proinflammation and profibrosis. We first investigate the levels of Th17 cells in primary biliary cirrhosis (PBC) patients, and then explore their distribution and fibrotic role in the disease. We compared the circulating Th17 and hepatic interleukin (IL)-17-positive cells between patients and healthy controls (HCs) at different disease stages by flow cytometry and immunohistochemistry, respectively. The levels of chemokine (c-c motif) ligand (CCL) 20 were then measured. For exploration of the reason why Th17 cells increased, CD4+CD161+ populations were sorted and cultured with IL-23 and IL-1β to analyze their proliferation and IL-17 secretions. The serum IL-23 and IL-1β were tested by enzyme-linked immunosorbent assay. The proliferation and expressions of α-smooth muscle actin and IL-8 of hepatic stellate cells (HSCs) were identified after stimulated by different concentrations of IL-17. Circulating and hepatic Th17 cells were elevated in PBC patients compared with HCs. Early PBC patients presented with more Th17 cells in periphery blood and less in the liver than advanced PBC patients. Accordingly, the levels of both serum and hepatic CCL20 for Th17 cells were higher, especially in those with advanced disease. The progenitor of Th17, CD4+CD161+ cell was increased in PBC. Moreover, the percentage of Th17 cells was positively related with CD4+CD161+ cell. After stimulation with IL-23 and IL-1β which were improved in PBC patients, CD4+CD161+ cells from PBC patients expressed more IL-17, although their proliferation were not different between 2 groups. IL-17 can promote the proliferation of HSCs at a dose-dependent method, and also increase the IL-8 expression in a dose/time-dependent way. Anti-IL-17 can neutralize the above reactions. CD4+CD161+ cells are a source of increased Th17 in PBC patients. With disease progression, Th17 population decreased in the circulation, accompanied by greater

  13. Parallelizing quantum circuit synthesis

    NASA Astrophysics Data System (ADS)

    Di Matteo, Olivia; Mosca, Michele

    2016-03-01

    Quantum circuit synthesis is the process in which an arbitrary unitary operation is decomposed into a sequence of gates from a universal set, typically one which a quantum computer can implement both efficiently and fault-tolerantly. As physical implementations of quantum computers improve, the need is growing for tools that can effectively synthesize components of the circuits and algorithms they will run. Existing algorithms for exact, multi-qubit circuit synthesis scale exponentially in the number of qubits and circuit depth, leaving synthesis intractable for circuits on more than a handful of qubits. Even modest improvements in circuit synthesis procedures may lead to significant advances, pushing forward the boundaries of not only the size of solvable circuit synthesis problems, but also in what can be realized physically as a result of having more efficient circuits. We present a method for quantum circuit synthesis using deterministic walks. Also termed pseudorandom walks, these are walks in which once a starting point is chosen, its path is completely determined. We apply our method to construct a parallel framework for circuit synthesis, and implement one such version performing optimal T-count synthesis over the Clifford+T gate set. We use our software to present examples where parallelization offers a significant speedup on the runtime, as well as directly confirm that the 4-qubit 1-bit full adder has optimal T-count 7 and T-depth 3.

  14. Chain Of Test Contacts For Integrated Circuits

    NASA Technical Reports Server (NTRS)

    Lieneweg, Udo

    1989-01-01

    Test structure forms chain of "cross" contacts fabricated together with large-scale integrated circuits. If necessary, number of such chains incorporated at suitable locations in integrated-circuit wafer for determination of fabrication yield of contacts. In new structure, resistances of individual contacts determined: In addition to making it possible to identify local defects, enables generation of statistical distributions of contact resistances for prediction of "parametric" contact yield of fabrication process.

  15. Brain Circuits Encoding Reward from Pain Relief

    PubMed Central

    Navratilova, Edita; Atcherley, Christopher; Porreca, Frank

    2015-01-01

    Relief from pain in humans is rewarding and pleasurable. Primary rewards, or reward predictive cues, are encoded in brain reward/motivational circuits. While considerable advances have been made in our understanding of reward circuits underlying positive reinforcement, less is known about the circuits underlying the hedonic and reinforcing actions of pain relief. We review findings from electrophysiological, neuroimaging and behavioral studies supporting the concept that the rewarding effect of pain relief requires opioid signaling in the anterior cingulate cortex, activation of midbrain dopamine neurons and release of dopamine in the nucleus accumbens. Understanding of circuits that govern the reward of pain relief may allow the discovery of more effective and satisfying therapies for patients with acute and chronic pain. PMID:26603560

  16. Remote reset circuit

    DOEpatents

    Gritzo, Russell E.

    1987-01-01

    A remote reset circuit acts as a stand-alone monitor and controller by clocking in each character sent by a terminal to a computer and comparing it to a given reference character. When a match occurs, the remote reset circuit activates the system's hardware reset line. The remote reset circuit is hardware based centered around monostable multivibrators and is unaffected by system crashes, partial serial transmissions, or power supply transients.

  17. Regenerative feedback resonant circuit

    DOEpatents

    Jones, A. Mark; Kelly, James F.; McCloy, John S.; McMakin, Douglas L.

    2014-09-02

    A regenerative feedback resonant circuit for measuring a transient response in a loop is disclosed. The circuit includes an amplifier for generating a signal in the loop. The circuit further includes a resonator having a resonant cavity and a material located within the cavity. The signal sent into the resonator produces a resonant frequency. A variation of the resonant frequency due to perturbations in electromagnetic properties of the material is measured.

  18. Input clustering in the normal and learned circuits of adult barn owls.

    PubMed

    McBride, Thomas J; DeBello, William M

    2015-05-01

    Experience-dependent formation of synaptic input clusters can occur in juvenile brains. Whether this also occurs in adults is largely unknown. We previously reconstructed the normal and learned circuits of prism-adapted barn owls and found that changes in clustering of axo-dendritic contacts (putative synapses) predicted functional circuit strength. Here we asked whether comparable changes occurred in normal and prism-removed adults. Across all anatomical zones, no systematic differences in the primary metrics for within-branch or between-branch clustering were observed: 95-99% of contacts resided within clusters (<10-20 μm from nearest neighbor) regardless of circuit strength. Bouton volumes, a proxy measure of synaptic strength, were on average larger in the functionally strong zones, indicating that changes in synaptic efficacy contributed to the differences in circuit strength. Bootstrap analysis showed that the distribution of inter-contact distances strongly deviated from random not in the functionally strong zones but in those that had been strong during the sensitive period (60-250 d), indicating that clusters formed early in life were preserved regardless of current value. While cluster formation in juveniles appeared to require the production of new synapses, cluster formation in adults did not. In total, these results support a model in which high cluster dynamics in juveniles sculpt a potential connectivity map that is refined in adulthood. We propose that preservation of clusters in functionally weak adult circuits provides a storage mechanism for disused but potentially useful pathways.

  19. Distributions.

    ERIC Educational Resources Information Center

    Bowers, Wayne A.

    This monograph was written for the Conference of the New Instructional Materials in Physics, held at the University of Washington in summer, 1965. It is intended for students who have had an introductory college physics course. It seeks to provide an introduction to the idea of distributions in general, and to some aspects of the subject in…

  20. Catheter transducer and circuit

    NASA Technical Reports Server (NTRS)

    Harrison, D. R.; Kerwin, W. J.

    1971-01-01

    Simple integrated circuit located at transducer, enables use of single coaxial cable for both input and output connections. Circuit is sensitive to changes in RC time constant, has much improved sensitivity characteristics, and is unaffected by changes in cable capacitance effects.

  1. A Virtual Circuits Lab

    ERIC Educational Resources Information Center

    Vick, Matthew E.

    2010-01-01

    The University of Colorado's Physics Education Technology (PhET) website offers free, high-quality simulations of many physics experiments that can be used in the classroom. The Circuit Construction Kit, for example, allows students to safely and constructively play with circuit components while learning the mathematics behind many circuit…

  2. Understanding Simple Circuits

    ERIC Educational Resources Information Center

    Mant, Jenny; Wilson, Helen

    2007-01-01

    Many envisage electricity as the "power" to "do things." They know that electricity needs "circuits" and that something is "flowing" in the circuits, but they are not sure what or why. Words such as "current" and "voltage" are part of electricity but their meaning, and the difference between them, is not always clear. In this article, the authors…

  3. Liquid detection circuit

    DOEpatents

    Regan, Thomas O.

    1987-01-01

    Herein is a circuit which is capable of detecting the presence of liquids, especially cryogenic liquids, and whose sensor will not overheat in a vacuum. The circuit parameters, however, can be adjusted to work with any liquid over a wide range of temperatures.

  4. Completing a Simple Circuit.

    ERIC Educational Resources Information Center

    Slater, Timothy F.; Adams, Jeffrey P.; Brown, Thomas R.

    2000-01-01

    Students have problems successfully arranging an electric circuit to make the bulb produce light. Investigates the percentage of students able to complete a circuit with a given apparatus, and the effects of prior experience on student success. Recommends hands-on activities at the elementary and secondary school levels. (Contains 14 references.)…

  5. Thermocouple-Signal-Conditioning Circuit

    NASA Technical Reports Server (NTRS)

    Simon, Richard A.

    1991-01-01

    Thermocouple-signal-conditioning circuit acting in conjunction with thermocouple, exhibits electrical behavior of voltage in series with resistance. Combination part of input bridge circuit of controller. Circuit configured for either of two specific applications by selection of alternative resistances and supply voltages. Includes alarm circuit detecting open circuit in thermocouple and provides off-scale output to signal malfunctions.

  6. Spatial distribution and risk assessment of metals in dust based on samples from nursery and primary schools of Xi'an, China

    NASA Astrophysics Data System (ADS)

    Chen, Hao; Lu, Xinwei; Li, Loretta Y.

    2014-05-01

    The spatial distribution of metal (Cu, Pb, Zn, As, Ba, Co, Cr, Mn, Ni and V) concentrations in urban dust of Xi'an, China was determined using the geographical information system method on dust from nursery and primary schools. The health risk of these metals in campus dust to children was assessed based on the EPA heath risk model. The results indicate elevated metal concentrations, especially of Cu, Pb, Zn, Co, Cr and Ba, which are 1.5-10.2, 2.6-73.0, 2.1-26.5, 2.0-10.9, 1.2-10.2 and 1.1-10.4 times the background values of Shaanxi soil, respectively. Pb, Cr, Cu and Ba have similar distribution patterns. The hot-spot areas of Pb, Zn, Cu, Co, Cr and Ba are mainly associated with industrial activities and heavy traffic. Their spatial distributions in the Xi'an urban dust indicated that these metals mainly originate from vehicles and industrial activities. For As, Mn, Ni and V, natural factors are important in controlling their distributions. Health risk assessment shows that ingestion is the largest exposure route of metals in dust from nursery and primary schools to children. The mean hazard indices for non-cancer risk of all analyzed metals due to campus dust are within the safe range, while the maximum hazard indices of Pb, Cr and As are close to, or slightly higher than, safe levels. The cancer risks of As, Co, Cr and Ni to nursery and primary school children, considering only inhalation, are within the acceptable range.

  7. Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection

    PubMed Central

    Titanji, Kehmia; Sammicheli, Stefano; De Milito, Angelo; Mantegani, Paola; Fortis, Claudio; Berg, Louise; Kärre, Klas; Travi, Giovanna; Tassandin, Chiara; Lopalco, Lucia; Rethi, Bence; Tambussi, Giuseppe; Chiodi, Francesca

    2008-01-01

    Human natural killer (NK) (CD3− CD56+) cells can be divided into two functionally distinct subsets, CD3− CD56dim and CD3− CD56bright. We analysed the distribution of NK cell subsets in primary and chronic human immunodeficiency virus-1 (HIV-1) infection, to determine if HIV infection stage may influence the subset distribution. In primary infection, contrary to chronic infection, the CD3− CD56dim subset was expanded compared to healthy controls. We also studied the effect of antiretroviral therapy administered early in infection and found that NK cell subset distribution was partially restored after 6 months of antiretroviral therapy in primary infection, but not normalized. Recently, NK cells have been divided into CD27− and CD27+ subsets with different migratory and functional capacity and CD27-mediated NK cell activation has been described in mice. We therefore investigated whether CD27 and/or CD70 (CD27 ligand) expression on NK cells, and thus the distribution of these novel NK subsets, was altered in HIV-1-infected patients. We found up-regulated expression of both CD27 and CD70 on NK cells of patients, resulting in higher proportions of CD27high and CD70high NK cells, and this phenomenon was more pronounced in chronic infection. Experiments conducted in vitro suggest that the high interleukin-7 levels found during HIV-1 infection may participate in up-regulation of CD70 on NK cell subsets. Imbalance of NK cell subsets and up-regulated expression of CD27 and CD70 initiated early in HIV-1 infection may indicate NK cell activation and intrinsic defects initiated by HIV-1 to disarm the innate immune response to the virus. PMID:17627773

  8. Compensated gain control circuit for buck regulator command charge circuit

    DOEpatents

    Barrett, David M.

    1996-01-01

    A buck regulator command charge circuit includes a compensated-gain control signal for compensating for changes in the component values in order to achieve optimal voltage regulation. The compensated-gain control circuit includes an automatic-gain control circuit for generating a variable-gain control signal. The automatic-gain control circuit is formed of a precision rectifier circuit, a filter network, an error amplifier, and an integrator circuit.

  9. Compensated gain control circuit for buck regulator command charge circuit

    DOEpatents

    Barrett, D.M.

    1996-11-05

    A buck regulator command charge circuit includes a compensated-gain control signal for compensating for changes in the component values in order to achieve optimal voltage regulation. The compensated-gain control circuit includes an automatic-gain control circuit for generating a variable-gain control signal. The automatic-gain control circuit is formed of a precision rectifier circuit, a filter network, an error amplifier, and an integrator circuit. 5 figs.

  10. Effect of the fuel bias distribution in the primary air nozzle on the slagging near a swirl coal burner throat

    SciTech Connect

    Lingyan Zeng; Zhengqi Li; Hong Cui; Fucheng Zhang; Zhichao Chen; Guangbo Zhao

    2009-09-15

    Three-dimensional numerical simulations of slagging characteristics near the burner throat region were carried out for swirl coal combustion burners used in a 1025 tons/h boiler. The gas/particle two-phase numerical simulation results and the data measured by a particle-dynamics anemometer (PDA) show that the numeration model was reasonable. For the centrally fuel-rich swirl coal combustion burner, the coal particles move in the following way. The particles first flow into furnace with the primary air from the burner throat. After traversing a certain distance, they move back to the burner throat and then toward the furnace again. Thus, particle trajectories are extended. For the case with equal air mass fluxes in the inner and outer primary air/coal mixtures, as the ratio of the coal mass flux in the inner primary air/coal mixture to the total coal mass flux increased from 40 (the reference condition) to 50%, 50 to 70%, and 70 to 100%, the maximum number density declined by 22, 11, and 4%, respectively, relative to the reference condition. In addition, the sticking particle ratio declined by 13, 14, and 8%, respectively, compared to the reference condition. 22 refs., 12 figs., 3 tabs.

  11. Distribution of binding sites for the plant lectin Ulex europaeus agglutinin I on primary sensory neurones in seven different mammalian species.

    PubMed

    Gerke, Michelle B; Plenderleith, Mark B

    2002-01-01

    There is an increasing body of evidence to suggest that different functional classes of neurones express characteristic cell-surface carbohydrates. Previous studies have shown that the plant lectin Ulex europaeus agglutinin-I (UEA) binds to a population of small to medium diameter primary sensory neurones in rabbits and humans. This suggests that a fucose-containing glycoconjugate may be expressed by nociceptive primary sensory neurones. In order to determine the extent to which this glycoconjugate is expressed by other species, in the current study, we have examined the distribution of UEA-binding sites on primary sensory neurones in seven different mammals. Binding sites for UEA were associated with the plasma membrane and cytoplasmic granules of small to medium dorsal root ganglion cells and their axon terminals in laminae I-III of the grey matter of the spinal cord, in the rabbit, cat and marmoset monkey. However, no binding was observed in either the dorsal root ganglia or spinal cord in the mouse, rat, guinea pig or flying fox. These results indicate an inter-species variation in the expression of cell-surface glycoconjugates on mammalian primary sensory neurones.

  12. Approximate circuits for increased reliability

    DOEpatents

    Hamlet, Jason R.; Mayo, Jackson R.

    2015-12-22

    Embodiments of the invention describe a Boolean circuit having a voter circuit and a plurality of approximate circuits each based, at least in part, on a reference circuit. The approximate circuits are each to generate one or more output signals based on values of received input signals. The voter circuit is to receive the one or more output signals generated by each of the approximate circuits, and is to output one or more signals corresponding to a majority value of the received signals. At least some of the approximate circuits are to generate an output value different than the reference circuit for one or more input signal values; however, for each possible input signal value, the majority values of the one or more output signals generated by the approximate circuits and received by the voter circuit correspond to output signal result values of the reference circuit.

  13. Approximate circuits for increased reliability

    SciTech Connect

    Hamlet, Jason R.; Mayo, Jackson R.

    2015-08-18

    Embodiments of the invention describe a Boolean circuit having a voter circuit and a plurality of approximate circuits each based, at least in part, on a reference circuit. The approximate circuits are each to generate one or more output signals based on values of received input signals. The voter circuit is to receive the one or more output signals generated by each of the approximate circuits, and is to output one or more signals corresponding to a majority value of the received signals. At least some of the approximate circuits are to generate an output value different than the reference circuit for one or more input signal values; however, for each possible input signal value, the majority values of the one or more output signals generated by the approximate circuits and received by the voter circuit correspond to output signal result values of the reference circuit.

  14. Effects of 13 T Static Magnetic Fields (SMF) in the Cell Cycle Distribution and Cell Viability in Immortalized Hamster Cells and Human Primary Fibroblasts Cells

    NASA Astrophysics Data System (ADS)

    Zhao, Guoping; Chen, Shaopeng; Zhao, Ye; Zhu, Lingyan; Huang, Pei; Bao, Lingzhi; Wang, Jun; Wang, Lei; Wu, Lijun; Wu, Yuejin; Xu, An

    2010-02-01

    Magnetic resonance image (MRI) systems with a much higher magnetic flux density were developed and applied for potential use in medical diagnostic. Recently, much attention has been paid to the biological effects of static, strong magnetic fields (SMF). With the 13 T SMF facility in the Institute of Plasma Physics, Chinese Academy of Sciences, the present study focused on the cellular effects of the SMF with 13 T on the cell viability and the cell cycle distribution in immortalized hamster cells, such as human-hamster hybrid (AL) cells, Chinese hamster ovary (CHO) cells, DNA double-strand break repair deficient mutant (XRS-5) cells, and human primary skin fibroblasts (AG1522) cells. It was found that the exposure of 13 T SMF had less effect on the colony formation in either nonsynchronized or synchronized AL cells. Moreover, as compared to non-exposed groups, there were slight differences in the cell cycle distribution no matter in either synchronized or nonsynchronized immortalized hamster cells after exposure to 13 T SMF. However, it should be noted that the percentage of exposed AG1522 cells at G0/G1 phase was decreased by 10% as compared to the controls. Our data indicated that although 13 T SMF had minimal effects in immortalized hamster cells, the cell cycle distribution was slightly modified by SMF in human primary fibroblasts.

  15. Sensor readout detector circuit

    DOEpatents

    Chu, D.D.; Thelen, D.C. Jr.

    1998-08-11

    A sensor readout detector circuit is disclosed that is capable of detecting sensor signals down to a few nanoamperes or less in a high (microampere) background noise level. The circuit operates at a very low standby power level and is triggerable by a sensor event signal that is above a predetermined threshold level. A plurality of sensor readout detector circuits can be formed on a substrate as an integrated circuit (IC). These circuits can operate to process data from an array of sensors in parallel, with only data from active sensors being processed for digitization and analysis. This allows the IC to operate at a low power level with a high data throughput for the active sensors. The circuit may be used with many different types of sensors, including photodetectors, capacitance sensors, chemically-sensitive sensors or combinations thereof to provide a capability for recording transient events or for recording data for a predetermined period of time following an event trigger. The sensor readout detector circuit has applications for portable or satellite-based sensor systems. 6 figs.

  16. Sensor readout detector circuit

    DOEpatents

    Chu, Dahlon D.; Thelen, Jr., Donald C.

    1998-01-01

    A sensor readout detector circuit is disclosed that is capable of detecting sensor signals down to a few nanoamperes or less in a high (microampere) background noise level. The circuit operates at a very low standby power level and is triggerable by a sensor event signal that is above a predetermined threshold level. A plurality of sensor readout detector circuits can be formed on a substrate as an integrated circuit (IC). These circuits can operate to process data from an array of sensors in parallel, with only data from active sensors being processed for digitization and analysis. This allows the IC to operate at a low power level with a high data throughput for the active sensors. The circuit may be used with many different types of sensors, including photodetectors, capacitance sensors, chemically-sensitive sensors or combinations thereof to provide a capability for recording transient events or for recording data for a predetermined period of time following an event trigger. The sensor readout detector circuit has applications for portable or satellite-based sensor systems.

  17. Net primary productivity distribution in the BOREAS region from a process model using satellite and surface data

    NASA Astrophysics Data System (ADS)

    Liu, J.; Chen, J. M.; Cihlar, J.; Chen, W.

    1999-11-01

    The purpose of this paper is to upscale tower measurements of net primary productivity (NPP) to the Boreal Ecosystem-Atmosphere Study (BOREAS) study region by means of remote sensing and modeling. The Boreal Ecosystem Productivity Simulator (BEPS) with a new daily canopy photosynthesis model was first tested in one coniferous and one deciduous site. The simultaneous CO2 flux measurements above and below the tree canopy made it possible to isolate daily net primary productivity of the tree canopy for model validation. Soil water holding capacity and gridded daily meteorological data for the region were used as inputs to BEPS, in addition to 1 km resolution land cover and leaf area index (LAI) maps derived from the advanced very high resolution radiometer (AVHRR) data. NPP statistics for the various cover types in the BOREAS region and in the southern study area (SSA) and the northern study area (NSA) are presented. Strong dependence of NPP on LAI was found for the three major cover types: coniferous forest, deciduous forest and cropland. Since BEPS can compute total photosynthetically active radiation absorbed by the canopy in each pixel, light use efficiencies for NPP and gross primary productivity could also be analyzed. From the model results, the following area-averaged statistics were obtained for 1994: (1) mean NPP for the BOREAS region of 217 g C m-2 yr-1; (2) mean NPP of forests (excluding burnt areas in the region) equal to 234 g C m-2 yr-1; (3) mean NPP for the SSA and the NSA of 297 and 238 g C m-2 yr-1, respectively; and (4) mean light use efficiency for NPP equal to 0.40, 0.20, and 0.33 g C (MJ APAR)-1 for deciduous forest, coniferous forest, and crops, respectively.

  18. The hemodynamic effects of the LVAD outflow cannula location on the thrombi distribution in the aorta: A primary numerical study.

    PubMed

    Zhang, Yage; Gao, Bin; Yu, Chang

    2016-09-01

    Although a growing number of patients undergo LVAD implantation for heart failure treatment, thrombi are still the devastating complication for patients who used LVAD. LVAD outflow cannula location and thrombi generation sources were hypothesized to affect the thrombi distribution in the aorta. To test this hypothesis, numerical studies were conducted by using computational fluid dynamic (CFD) theory. Two anastomotic configurations, in which the LVAD outflow cannula is anastomosed to the anterior and lateral ascending aortic wall (named as anterior configurations and lateral configurations, respectively), are designed. The particles, whose sized are same as those of thrombi, are released at the LVAD output cannula and the aortic valve (named as thrombiP and thrombiL, respectively) to calculate the distribution of thrombi. The simulation results demonstrate that the thrombi distribution in the aorta is significantly affected by the LVAD outflow cannula location. In anterior configuration, the thrombi probability of entering into the three branches is 23.60%, while that in lateral configuration is 36.68%. Similarly, in anterior configuration, the thrombi probabilities of entering into brachiocephalic artery, left common carotid artery and left subclavian artery, is 8.51%, 9.64%, 5.45%, respectively, while that in lateral configuration it is 11.39%, 3.09%, 22.20% respectively. Moreover, the origins of thrombi could affect their distributions in the aorta. In anterior configuration, the thrombiP has a lower probability to enter into the three branches than thrombiL (12% vs. 25%). In contrast, in lateral configuration, the thrombiP has a higher probability to enter into the three branches than thrombiL (47% vs. 35%). In brief, the LVAD outflow cannula location significantly affects the distribution of thrombi in the aorta. Thus, in the clinical practice, the selection of outflow location of LVAD and the risk of thrombi formed in the left ventricle should be paid more

  19. DIFFERENTIAL FAULT SENSING CIRCUIT

    DOEpatents

    Roberts, J.H.

    1961-09-01

    A differential fault sensing circuit is designed for detecting arcing in high-voltage vacuum tubes arranged in parallel. A circuit is provided which senses differences in voltages appearing between corresponding elements likely to fault. Sensitivity of the circuit is adjusted to some level above which arcing will cause detectable differences in voltage. For particular corresponding elements, a group of pulse transformers are connected in parallel with diodes connected across the secondaries thereof so that only voltage excursions are transmitted to a thyratron which is biased to the sensitivity level mentioned.

  20. Gallium Arsenide Domino Circuit

    NASA Technical Reports Server (NTRS)

    Yang, Long; Long, Stephen I.

    1990-01-01

    Advantages include reduced power and high speed. Experimental gallium arsenide field-effect-transistor (FET) domino circuit replicated in large numbers for use in dynamic-logic systems. Name of circuit denotes mode of operation, which logic signals propagate from each stage to next when successive stages operated at slightly staggered clock cycles, in manner reminiscent of dominoes falling in a row. Building block of domino circuit includes input, inverter, and level-shifting substages. Combinational logic executed in input substage. During low half of clock cycle, result of logic operation transmitted to following stage.

  1. Monolithic microwave integrated circuits

    NASA Astrophysics Data System (ADS)

    Pucel, R. A.

    Monolithic microwave integrated circuits (MMICs), a new microwave technology which is expected to exert a profound influence on microwave circuit designs for future military systems as well as for the commercial and consumer markets, is discussed. The book contains an historical discussion followed by a comprehensive review presenting the current status in the field. The general topics of the volume are: design considerations, materials and processing considerations, monolithic circuit applications, and CAD, measurement, and packaging techniques. All phases of MMIC technology are covered, from design to testing.

  2. Exploring New RF Circuit Structures with Embedded Patterned Substrate Layers

    DTIC Science & Technology

    2013-06-12

    spaced microstrip lines are common in T/R module packages and other high density circuit packages. The work involved creating a method to reduce the...Jan-2013 Approved for Public Release; Distribution Unlimited Final Report: Exploring New RF Circuit Structures with Embedded Patterned Substrate...Report: Exploring New RF Circuit Structures with Embedded Patterned Substrate Layers Report Title This report presents the findings made under the ARO

  3. Distribution of the Primary Endosymbiont (Candidatus Uzinura Diaspidicola) Within Host Insects from the Scale Insect Family Diaspididae.

    PubMed

    Gruwell, Matthew E; Flarhety, Meghan; Dittmar, Katharina

    2012-02-29

    It has long been known that armored scale insects harbor endosymbiotic bacteria inside specialized cells called bacteriocytes. Originally, these endosymbionts were thought to be fungal symbionts but they are now known to be bacterial and have been named Uzinura diaspidicola. Bacteriocyte and endosymbiont distribution patterns within host insects were visualized using in situ hybridization via 16S rRNA specific probes. Images of scale insect embryos, eggs and adult scale insects show patterns of localized bacteriocytes in embryos and randomly distributed bacteriocytes in adults. The symbiont pocket was not found in the armored scale insect eggs that were tested. The pattern of dispersed bacteriocytes in adult scale insects suggest that Uzinura and Blattabacteria may share some homologous traits that coincide with similar life style requirements, such as dispersal in fat bodies and uric acid recycling.

  4. Distribution of the Primary Endosymbiont (Candidatus Uzinura Diaspidicola) Within Host Insects from the Scale Insect Family Diaspididae

    PubMed Central

    Gruwell, Matthew E.; Flarhety, Meghan; Dittmar, Katharina

    2012-01-01

    It has long been known that armored scale insects harbor endosymbiotic bacteria inside specialized cells called bacteriocytes. Originally, these endosymbionts were thought to be fungal symbionts but they are now known to be bacterial and have been named Uzinura diaspidicola. Bacteriocyte and endosymbiont distribution patterns within host insects were visualized using in situ hybridization via 16S rRNA specific probes. Images of scale insect embryos, eggs and adult scale insects show patterns of localized bacteriocytes in embryos and randomly distributed bacteriocytes in adults. The symbiont pocket was not found in the armored scale insect eggs that were tested. The pattern of dispersed bacteriocytes in adult scale insects suggest that Uzinura and Blattabacteria may share some homologous traits that coincide with similar life style requirements, such as dispersal in fat bodies and uric acid recycling. PMID:26467959

  5. Cell types, circuits, computation.

    PubMed

    Azeredo da Silveira, Rava; Roska, Botond

    2011-10-01

    How does the connectivity of a neuronal circuit, together with the individual properties of the cell types that take part in it, result in a given computation? We examine this question in the context of retinal circuits. We suggest that the retina can be viewed as a parallel assemblage of many small computational devices, highly stereotypical and task-specific circuits afferent to a given ganglion cell type, and we discuss some rules that govern computation in these devices. Multi-device processing in retina poses conceptual problems when it is contrasted with cortical processing. We lay out open questions both on processing in retinal circuits and on implications for cortical processing of retinal inputs.

  6. Distribution of throughfall and stemflow in multi-strata agroforestry, perennial monoculture, fallow and primary forest in central Amazonia, Brazil

    NASA Astrophysics Data System (ADS)

    Schroth, Götz; Ferreira da Silva, Luciana; Wolf, Marc-Andree; Geraldes Teixeira, Wenceslau; Zech, Wolfgang

    1999-07-01

    The partitioning of rain water into throughfall, stemflow and interception loss when passing through plant canopies depends on properties of the respective plant species, such as leaf area and branch angles. In heterogeneous vegetation, such as tropical forest or polycultural systems, the presence of different plant species may consequently result in a mosaic of situations with respect to quantity and quality of water inputs into the soil. As these processes influence not only the water availability for the plants, but also water infiltration and nutrient leaching, the understanding of plant effects on the repartitioning of rain water may help in the optimization of land use systems and management practices. We measured throughfall and stemflow in a perennial polyculture (multi-strata agroforestry), monocultures of peach palm (Bactris gasipaes) for fruit and for palmito, a monoculture of cupuaçu (Theobroma grandiflorum), spontaneous fallow and primary forest during one year in central Amazonia, Brazil. The effect on rain water partitioning was measured separately for four useful tree species in the polyculture and for two tree species in the primary forest. Throughfall at two stem distances, and stemflow, differed significantly between tree species, resulting in pronounced spatial patterns of water input into the soil in the polyculture system. For two tree species, peach palm for fruit (Bactris gasipaes) and Brazil nut trees (Bertholletia excelsa), the water input into the soil near the stem was significantly higher than the open-area rainfall. This could lead to increased nutrient leaching when fertilizer is applied close to the stem of these trees. In the primary forest, such spatial patterns could also be detected, with significantly higher water input near a palm (Oenocarpus bacaba) than near a dicotyledonous tree species (Eschweilera sp.). Interception losses were 6·4% in the polyculture, 13·9 and 12·3% in the peach palm monocultures for fruit and for

  7. Power supply conditioning circuit

    NASA Technical Reports Server (NTRS)

    Primas, Lori E. (Inventor); Loveland, Rohan C. (Inventor)

    1988-01-01

    A conditioning circuit is provided with a constant current diode in series with a zener diode, the former having a high dynamic impedance and the latter a low dynamic impedance. The constant current diode can receive an input voltage with PARD. In conjunction with the zener diode fixed to a ground, a voltage divider is provided which can give an output voltage whose PARD was significantly reduced. The conditioning circuit is effective down to dc.

  8. Overriding Faulty Circuit Breakers

    NASA Technical Reports Server (NTRS)

    Robbins, Richard L.; Pierson, Thomas E.

    1987-01-01

    Retainer keeps power on in emergency. Simple mechanical device attaches to failed aircraft-type push/pull circuit breaker to restore electrical power temporarily until breaker replaced. Device holds push/pull button in closed position; unnecessary for crewmember to hold button in position by continual finger pressure. Sleeve and plug hold button in, overriding mechanical failure in circuit breaker. Windows in sleeve show button position.

  9. Distribution of primary cochlear afferents in the bulbar nuclei of the rat: a horseradish peroxidase (HRP) study in parasagittal sections.

    PubMed Central

    Merchan, M A; Collia, F P; Merchan, J A; Ludeña, M D

    1986-01-01

    HRP was injected into the cochleae of 25 young albino rats in order to trace the primary afferents to the bulbar cochlear nuclei. Besides the classic V-shaped pattern and unconnected with it, HRP labelling revealed two plexuses stemming directly from the axons of the cochlear root. The plexuses cover the posterior area of the posteroventral cochlear nucleus (posterior plexus) and the anterolaterodorsal area of the anteroventral cochlear nucleus (anterior plexus). The fibres giving rise to these two plexuses were previously grouped in two bundles which have been called the posterior and anterior bundles, respectively. The origin of the anterior bundle is typically seen with the fibres stemming out at right angles; the origin and course of the posterior bundle, which characteristically cross over, is also a typical feature. Images Fig. 1 Figs. 2-3 (cont.) Figs. 2-3 Fig. 4 PMID:3319993

  10. A three-ring circuit model of the magnetosphere

    NASA Technical Reports Server (NTRS)

    Whipple, E. C., Jr.; Mcilwain, C. E.; Alfven, H.

    1981-01-01

    The magnetosphere is modeled by superimposing a dipole field, a uniform field and a perturbation field due to a simple current system. This current system comprises a ring current in the neutral line of the dipole plus uniform fields, together with vertical currents representing field-aligned currents to the neutral line. The current circuit is closed through two additional ring currents above and below the equatorial plane representing distributed adiabatic perpendicular currents. This system produces many magnetospheric features, among them a magnetopause, bending of magnetic field lines in the anti-solar direction, a magnetotail, and cusps in the day-side of the earth. The objective is to demonstrate that it is not necessary to think of the magnetic field topology as being caused by the flowing plasma carrying field lines. The primary physical problem is to derive the current system from the self-consistent interaction of the solar-wind and magnetospheric plasmas and fields.

  11. Circuit theory of non-equilibrium superconductivity

    NASA Astrophysics Data System (ADS)

    Nazarov, Yuli V.

    2001-04-01

    We give here a short account of a recently developed circuit theory of superconductivity. The theory accounts for decoherence between electrons and holes, twofold nature of the distribution function in the superconducting state and includes arbitrary connectors. We give a simple example and discuss numerical implementation of the theory.

  12. Multi-purpose droop controllers incorporating a passivity-based stabilizer for unified control of electronically interfaced distributed generators including primary source dynamics.

    PubMed

    Azimi, Seyed Mohammad; Afsharnia, Saeed

    2016-07-01

    This paper presents multi-purpose droop controllers for electronically-interfaced distributed generators (EI-DGs). These controllers allow the micro-grids to operate in grid-connected mode, islanded mode and mode transition transients with a unique control configuration. The active and reactive-power sharing among EI-DGs are satisfied by the proposed droop controllers in islanded mode. On the other hand, in the grid-connected mode, the droop controllers adjust the output active and reactive-powers of EI-DGs at the pre-programmed constant levels. The provision of sufficient damping capability and maintenance of the transient stability in all operational modes of EI-DGs are warranted by the suggested stabilizer. This stabilizer, which is designed using the passivity-based control (PBC) approach, is incorporated in the droop controllers to dampen power-angle, frequency and voltage deviations during large transients using solely local information. The primary source dynamics of EI-DGs are also considered. It is analytically proven that the presence of the primary source dynamics leads to attenuation of the damping capability of EI-DGs in transients. To compensate the adverse effect of the primary source dynamics during transients a novel compensator is inserted in the frequency-droop loop. Finally, time-domain simulations are performed on a multi-resources MG to verify the analytical results compared to those obtained, based on a recently-developed strategy.

  13. Prediction of phase distribution pattern in phase field simulations on Mo5SiB2-primary areas in near eutectic Mo-Si-B alloy

    NASA Astrophysics Data System (ADS)

    Kazemi, O.; Hasemann, G.; Krüger, M.; Halle, T.

    2017-03-01

    A Mo-10.9Si-20.3B (if not stated otherwise all compositions are given in at.%) alloy was modeled using the phase field method with linearized phase diagrams and thermodynamic data. The simulation results showed that there are two specific microstructural constituents. According to the simulations and experimental microstructural investigations the primary Mo5SiB2 phase observed in this study was combined by the Moss-Mo3Si-Mo5SiB2 eutectics. The overall composition of the both primary and eutectic area was probed and the phase evolution along with the concentration change of the core areas were explored and visualized in the solidification domain. To verify the accuracy of the simulation results, they were comprised with the experimental achievements. In terms of the fraction of phases, the portion of the primary phase and the eutectic constituent and the phase distribution pattern our results were in good agreement with the experimental observations.

  14. Power supply circuit for an ion engine sequentially operated power inverters

    NASA Technical Reports Server (NTRS)

    Cardwell, Jr., Gilbert I. (Inventor)

    2000-01-01

    A power supply circuit for an ion engine suitable for a spacecraft has a voltage bus having input line and a return line. The power supply circuit includes a pulse width modulation circuit. A plurality of bridge inverter circuits is coupled to the bus and the pulse width modulation circuit. The pulse width modulation circuit generates operating signals having a variable duty cycle. Each bridge inverter has a primary winding and a secondary winding. Each secondary winding is coupled to a rectifier bridge. Each secondary winding is coupled in series with another of the plurality of rectifier bridges.

  15. Spatial patterns of primary productivity derived from the Dynamic Habitat Indices predict patterns of species richness and distributions in the tropics

    NASA Astrophysics Data System (ADS)

    Suttidate, Naparat

    Humans are changing the Earth's ecosystems, which has profound consequences for biodiversity. To understand how species respond to these changes, biodiversity science requires accurate assessments of biodiversity. However, biodiversity assessments are still limited in tropical regions. The Dynamic Habitat Indices (DHIs), derived from satellite data, summarize dynamic patterns of annual primary productivity: (a) cumulative annual productivity, (b) minimum annual productivity, and (c) seasonal variation in productivity. The DHIs have been successfully used in temperate regions, but not yet in the tropics. My goal was to evaluate the importance of primary productivity measured via the DHIs for assessing patterns of species richness and distributions in Thailand. First, I assessed the relationships between the DHIs and tropical bird species richness. I also evaluated the complementarity of the DHIs and topography, climate, latitudinal gradients, habitat heterogeneity, and habitat area in explaining bird species richness. I found that among three DHIs, cumulative annual productivity was the most important factor in explaining bird species richness and that the DHIs outperformed other environmental variables. Second, I developed texture measures derive from DHI cumulative annual productivity, and compared them to habitat composition and fragmentation as predictors of tropical forest bird distributions. I found that adding texture measures to habitat composition and fragmentation models improved the prediction of tropical bird distributions, especially area- and edge-sensitive tropical forest bird species. Third, I predicted the effects of trophic interactions between primary productivity, prey, and predators in relation to habitat connectivity for Indochinese tigers (Panthera tigris). I found that including trophic interactions improved habitat suitability models for tigers. However, tiger habitat is highly fragmented with few dispersal corridors. I also identified

  16. Geographical distribution of the annual mean radon concentrations in primary schools of Southern Serbia - application of geostatistical methods.

    PubMed

    Bossew, P; Žunić, Z S; Stojanovska, Z; Tollefsen, T; Carpentieri, C; Veselinović, N; Komatina, S; Vaupotič, J; Simović, R D; Antignani, S; Bochicchio, F

    2014-01-01

    Between 2008 and 2011 a survey of radon ((222)Rn) was performed in schools of several districts of Southern Serbia. Some results have been published previously (Žunić et al., 2010; Carpentieri et al., 2011; Žunić et al., 2013). This article concentrates on the geographical distribution of the measured Rn concentrations. Applying geostatistical methods we generate "school radon maps" of expected concentrations and of estimated probabilities that a concentration threshold is exceeded. The resulting maps show a clearly structured spatial pattern which appears related to the geological background. In particular in areas with vulcanite and granitoid rocks, elevated radon (Rn) concentrations can be expected. The "school radon map" can therefore be considered as proxy to a map of the geogenic radon potential, and allows identification of radon-prone areas, i.e. areas in which higher Rn radon concentrations can be expected for natural reasons. It must be stressed that the "radon hazard", or potential risk, estimated this way, has to be distinguished from the actual radon risk, which is a function of exposure. This in turn may require (depending on the target variable which is supposed to measure risk) considering demographic and sociological reality, i.e. population density, distribution of building styles and living habits.

  17. Spatial variability of primary organic sources regulates ichthyofauna distribution despite seasonal influence in Terminos lagoon and continental shelf of Campeche, Mexico

    NASA Astrophysics Data System (ADS)

    Romo Rios, J. A.; Aguíñiga-García, S.; Sanchez, A.; Zetina-Rejón, M.; Arreguín-Sánchez, F.; Tripp-Valdéz, A.; Galeana-Cortazár, A.

    2013-05-01

    Human activities have strong impacts on coastal ecosystems functioning through their effect on primary organic sources distributions and resulting biodiversity. Hence, it appears to be of utmost importance to quantify contribution of primary producers to sediment organic matter (SOM) spatial variability and its associated ichthyofauna. The Terminos lagoon (Gulf of Mexico) is a tropical estuary severely impacted by human activities even though of primary concern for its biodiversity, its habitats, and its resource supply. Stable isotope data (d13C, d15N) from mangrove, seaweed, seagrass, phytoplankton, ichthyofauna and SOM were sampled in four zones of the lagoon and the continental shelf through windy (November to February), dry (March to June) and rainy (July to October) seasons. Stable Isotope Analysis in R (SIAR) mixing model were used to determine relative contributions of the autotrophic sources to the ichthyofauna and SOM. Analysis of variance of ichthyofauna isotopic values showed significant differences (P < 0.001) in the four zones of lagoon despite the variability introduced by the windy, dry and rainy seasons. In lagoons rivers discharge zone, the mangrove contribution to ichthyofauna was 40% and 84% to SOM. Alternative use of habitat by ichthyofauna was evidenced since in the deep area of the lagoon (4 m), the contribution of mangrove to fish is 50%, and meanwhile contribution to SOM is only 77%. Although phytoplankton (43%) and seaweed (41%) contributions to the adjacent continental shelf ichthyofauna were the main organic sources, there was 37% mangrove contribution to SOM, demonstrating conspicuous terrigenous influence from lagoon ecosystem. Our results point toward organic sources spatial variations that regulate fish distribution. In Terminos lagoon, significant correlation (p-value = 0.2141 and r=0.79) of Ariopsis felis and Sphoeroides testudineus abundances and seaweed and seagrasses contributions (30-35%) during both dry and rainy seasons

  18. Vibration Damping Circuit Card Assembly

    NASA Technical Reports Server (NTRS)

    Hunt, Ronald Allen (Inventor)

    2016-01-01

    A vibration damping circuit card assembly includes a populated circuit card having a mass M. A closed metal container is coupled to a surface of the populated circuit card at approximately a geometric center of the populated circuit card. Tungsten balls fill approximately 90% of the metal container with a collective mass of the tungsten balls being approximately (0.07) M.

  19. Exchange circuits for FASTBUS slaves

    SciTech Connect

    Bratskii, A.A.; Matseev, M.Y.; Rybakov, V.G.

    1985-09-01

    This paper describes general-purpose circuits for FASTBUS interfacing of the functional part of a slave device. The circuits contain buffered receivers and transmitters, addressrecognition and data-transfer logic, and the required control/status registers. The described circuits are implemented with series-K500 integrated circuits.

  20. Circuit simulation: some humbling thoughts

    SciTech Connect

    Wendt, Manfred; /Fermilab

    2006-01-01

    A short, very personal note on circuit simulation is presented. It does neither include theoretical background on circuit simulation, nor offers an overview of available software, but just gives some general remarks for a discussion on circuit simulator needs in context to the design and development of accelerator beam instrumentation circuits and systems.

  1. Superconducting flux flow digital circuits

    DOEpatents

    Hietala, Vincent M.; Martens, Jon S.; Zipperian, Thomas E.

    1995-01-01

    A NOR/inverter logic gate circuit and a flip flop circuit implemented with superconducting flux flow transistors (SFFTs). Both circuits comprise two SFFTs with feedback lines. They have extremely low power dissipation, very high switching speeds, and the ability to interface between Josephson junction superconductor circuits and conventional microelectronics.

  2. Superconducting flux flow digital circuits

    DOEpatents

    Hietala, V.M.; Martens, J.S.; Zipperian, T.E.

    1995-02-14

    A NOR/inverter logic gate circuit and a flip flop circuit implemented with superconducting flux flow transistors (SFFTs) are disclosed. Both circuits comprise two SFFTs with feedback lines. They have extremely low power dissipation, very high switching speeds, and the ability to interface between Josephson junction superconductor circuits and conventional microelectronics. 8 figs.

  3. Farming the planet: 2. Geographic distribution of crop areas, yields, physiological types, and net primary production in the year 2000

    NASA Astrophysics Data System (ADS)

    Monfreda, Chad; Ramankutty, Navin; Foley, Jonathan A.

    2008-03-01

    Croplands cover ~15 million km2 of the planet and provide the bulk of the food and fiber essential to human well-being. Most global land cover data sets from satellites group croplands into just a few categories, thereby excluding information that is critical for answering key questions ranging from biodiversity conservation to food security to biogeochemical cycling. Information about agricultural land use practices like crop selection, yield, and fertilizer use is even more limited. Here we present land use data sets created by combining national, state, and county level census statistics with a recently updated global data set of croplands on a 5 min by 5 min (~10 km by 10 km) latitude-longitude grid. The resulting land use data sets depict circa the year 2000 the area (harvested) and yield of 175 distinct crops of the world. We aggregate these individual crop maps to produce novel maps of 11 major crop groups, crop net primary production, and four physiologically based crop types: annuals/perennials, herbaceous/shrubs/trees, C3/C4, and leguminous/nonleguminous.

  4. Two-photon mapping of neocortical circuits

    NASA Astrophysics Data System (ADS)

    Nikolenko, Volodymyr

    The synaptic circuits of the cerebral cortex are still poorly understood, yet knowing their basic structure appears key for understanding their function (Lorente de No, 1949). While some argue that there is a basic modular circuit present in all cortical regions (Douglas et al., 1989; Hubel and Wiesel, 1977), others suggest that synaptic circuits could be randomly structured (Braitenberg and Schuz, 1998). To investigate the patterns of synaptic connections present in neocortex, I have developed a novel two-photon optical mapping method (Nikolenko et al., 2007) to systematically reveal cells that connect to four classes of neurons in slices of mouse primary sensory cortex. Inputs to these cells originated preferentially from specific cortical layers and often were laterally restricted, revealing functional columnar circuits with sharp boundaries. Moreover, many neurons extensively sampled particular territories, and, in some cases, virtually every cell from a particular layer was connected to the postsynaptic target. The results reveal circuits with dense columnar connectivity, approximating in some cases the complete sampling from every potential presynaptic cell in an input layer. I discuss the implications of these findings in the context of the computational strategies used by the cortex.

  5. MAGE-3 immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: frequency and distribution.

    PubMed Central

    Hofbauer, G. F.; Schaefer, C.; Noppen, C.; Böni, R.; Kamarashev, J.; Nestle, F. O.; Spagnoli, G. C.; Dummer, R.

    1997-01-01

    Monoclonal antibody 57B specifically detects MAGE-3 gene protein expression. MAGE-derived peptides are recognized by CD8+ T cells and applied in immunotherapy. We examined formalin-fixed, paraffin-embedded tissue of 61 melanoma (primary, n = 40; metastatic, n = 21) and 46 control cases (junctional, dermal, compound, Spitz, Reed, and balloon-cell nevi) by immunohistochemistry using the alkaline phosphatase anti-alkaline phosphatase method after antigen retrieval. Immunoreactivity was rated positive at 20 positive cells per tumor or more. Staining pattern was homogeneous, scattered, or focal. All control samples and internal controls were immunonegative. Staining with monoclonal antibody 57B showed a specificity of 100% with a sensitivity of 44%. Immunopositivity (overall, 44% of melanomas) increased along with tumor, node, and metastasis stage; pT1 showed 13%, pT2 22%, pT3a 29%, pT3b 45%, pT4 100%, pTxN1 60%, and pTxNxM1a 63% of samples positive. The staining pattern was homogeneous on pT1 to pT3a tumors, homogeneous or focal in pT3b and pT4a, and homogeneous, focal, or scattered in pTxN1 and pTxNxM1a. The frequency of immunopositivity relates well to data on mRNA expression using reverse transcriptase polymerase chain reaction in a subgroup analyzed by both methods. Monoclonal antibody 57B can be used to allow profiling of melanomas using routine archival tissue, when considering immunotherapeutic approaches involving MAGE-3-derived epitopes. Images Figure 1 Figure 2 Figure 3 PMID:9403705

  6. Applying analog integrated circuits for HERO protection

    NASA Technical Reports Server (NTRS)

    Willis, Kenneth E.; Blachowski, Thomas J.

    1994-01-01

    One of the most efficient methods for protecting electro-explosive devices (EED's) from HERO and ESD is to shield the EED in a conducting shell (Faraday cage). Electrical energy is transferred to the bridge by means of a magnetic coupling which passes through a portion of the conducting shell that is made from a magnetically permeable but electrically conducting material. This technique was perfected by ML Aviation, a U.K. company, in the early 80's, and was called a Radio Frequency Attenuation Connector (RFAC). It is now in wide use in the U.K. Previously, the disadvantage of RFAC over more conventional methods was its relatively high cost, largely driven by a thick film hybrid circuit used to switch the primary of the transformer. Recently, through a licensing agreement, this technology has been transferred to the U.S. and significant cost reductions and performance improvements have been achieved by the introduction of analog integrated circuits. An integrated circuit performs the following functions: (1) Chops the DC input to a signal suitable for driving the primary of the transformer; (2) Verifies the input voltage is above a threshold; (3) Verifies the input voltage is valid for a pre set time before enabling the device; (4) Provides thermal protection of the circuit; and (5) Provides an external input for independent logic level enabling of the power transfer mechanism. This paper describes the new RFAC product and its applications.

  7. Microfluidic serial dilution circuit.

    PubMed

    Paegel, Brian M; Grover, William H; Skelley, Alison M; Mathies, Richard A; Joyce, Gerald F

    2006-11-01

    In vitro evolution of RNA molecules requires a method for executing many consecutive serial dilutions. To solve this problem, a microfluidic circuit has been fabricated in a three-layer glass-PDMS-glass device. The 400-nL serial dilution circuit contains five integrated membrane valves: three two-way valves arranged in a loop to drive cyclic mixing of the diluent and carryover, and two bus valves to control fluidic access to the circuit through input and output channels. By varying the valve placement in the circuit, carryover fractions from 0.04 to 0.2 were obtained. Each dilution process, which is composed of a diluent flush cycle followed by a mixing cycle, is carried out with no pipeting, and a sample volume of 400 nL is sufficient for conducting an arbitrary number of serial dilutions. Mixing is precisely controlled by changing the cyclic pumping rate, with a minimum mixing time of 22 s. This microfluidic circuit is generally applicable for integrating automated serial dilution and sample preparation in almost any microfluidic architecture.

  8. Black-box superconducting circuit quantization.

    PubMed

    Nigg, Simon E; Paik, Hanhee; Vlastakis, Brian; Kirchmair, Gerhard; Shankar, S; Frunzio, Luigi; Devoret, M H; Schoelkopf, R J; Girvin, S M

    2012-06-15

    We present a semiclassical method for determining the effective low-energy quantum Hamiltonian of weakly anharmonic superconducting circuits containing mesoscopic Josephson junctions coupled to electromagnetic environments made of an arbitrary combination of distributed and lumped elements. A convenient basis, capturing the multimode physics, is given by the quantized eigenmodes of the linearized circuit and is fully determined by a classical linear response function. The method is used to calculate numerically the low-energy spectrum of a 3D transmon system, and quantitative agreement with measurements is found.

  9. Dependence of the neutron monitor count rate and time delay distribution on the rigidity spectrum of primary cosmic rays

    NASA Astrophysics Data System (ADS)

    Mangeard, P.-S.; Ruffolo, D.; Sáiz, A.; Nuntiyakul, W.; Bieber, J. W.; Clem, J.; Evenson, P.; Pyle, R.; Duldig, M. L.; Humble, J. E.

    2016-12-01

    Neutron monitors are the premier instruments for precisely tracking time variations in the Galactic cosmic ray flux at GeV-range energies above the geomagnetic cutoff at the location of measurement. Recently, a new capability has been developed to record and analyze the neutron time delay distribution (related to neutron multiplicity) to infer variations in the cosmic ray spectrum as well. In particular, from time delay histograms we can determine the leader fraction L, defined as the fraction of neutrons that did not follow a previous neutron detection in the same tube from the same atmospheric secondary particle. Using data taken during 2000-2007 by a shipborne neutron monitor latitude survey, we observe a strong dependence of the count rate and L on the geomagnetic cutoff. We have modeled this dependence using Monte Carlo simulations of cosmic ray interactions in the atmosphere and in the neutron monitor. We present new yield functions for the count rate of a neutron monitor at sea level. The simulation results show a variation of L with geomagnetic cutoff as observed by the latitude survey, confirming that these changes in L can be attributed to changes in the cosmic ray spectrum arriving at Earth's atmosphere. We also observe a variation in L with time at a fixed cutoff, which reflects the evolution of the cosmic ray spectrum with the sunspot cycle, known as solar modulation.

  10. Distribution and quantitation of skin iron in primary haemochromatosis: correlation with total body iron stores in patients undergoing phlebotomy.

    PubMed

    Pinheiro, Teresa; Silva, Raquel; Fleming, Rita; Gonçalves, Afonso; Barreiros, Maria A; Silva, João N; Morlière, Patrice; Santus, René; Filipe, Paulo

    2014-01-01

    Measurement of the concentration of iron in the skin, if correlated with total body iron stores, may enable better informed decisions on when to initiate, change or stop therapy in hereditary heamochromatosis. Naïve haemochromatosis patients with iron overload and with C282Y and/or H63D HFE mutations were evaluated at the following time-points: disease diagnosis, end of the therapy programme, and 6 months after the end of therapy. The distribution and concentration of iron in the skin were assessed by quantitative nuclear microscopy methods, in parallel with serum and plasma iron concentration. Iron content in the liver was determined by nuclear magnetic resonance. Iron accumulated in the epidermis; its concentration increased from outer to inner layers, being maximal in the basal layer (7.33 ± 0.98 µmol/g). At all 3 time-points, most of the iron was associated with the extracellular space. During the phlebotomy programme the iron content of the skin and the liver decreased by a factor of 2. These data suggest that measurements of iron concentration in the epidermis, which is a readily accessible tissue, reflect iron overload in the liver.

  11. The distribution of lung cancer across sectors of society in the United Kingdom: a study using national primary care data

    PubMed Central

    2011-01-01

    Background There is pressing need to diagnose lung cancer earlier in the United Kingdom (UK) and it is likely that research using computerised general practice records will help this process. Linkage of these records to area-level geo-demographic classifications may also facilitate case ascertainment for public health programmes, however, there have as yet been no extensive studies of data validity for such purposes. Methods To first address the need for validation, we assessed the completeness and representativeness of lung cancer data from The Health Improvement Network (THIN) national primary care database by comparing incidence and survival between 2000 and 2009 with the UK National Cancer Registry and the National Lung Cancer Audit Database. Secondly, we explored the potential of a geo-demographic social marketing tool to facilitate disease ascertainment by using Experian's Mosaic Public Sector ™ classification, to identify detailed profiles of the sectors of society where lung cancer incidence was highest. Results Overall incidence of lung cancer (41.4/100, 000 person-years, 95% confidence interval 40.6-42.1) and median survival (232 days) were similar to other national data; The incidence rate in THIN from 2003-2006 was found to be just over 93% of the national cancer registry rate. Incidence increased considerably with area-level deprivation measured by the Townsend Index and was highest in the North-West of England (65.1/100, 000 person-years). Wider variations in incidence were however identified using Mosaic classifications with the highest incidence in Mosaic Public Sector ™types 'Cared-for pensioners, ' 'Old people in flats' and 'Dignified dependency' (191.7, 174.2 and 117.1 per 100, 000 person-years respectively). Conclusions Routine electronic data in THIN are a valid source of lung cancer information. Mosaic ™ identified greater incidence differentials than standard area-level measures and as such could be used as a tool for public health

  12. ELECTRONIC PHASE CONTROL CIRCUIT

    DOEpatents

    Salisbury, J.D.; Klein, W.W.; Hansen, C.F.

    1959-04-21

    An electronic circuit is described for controlling the phase of radio frequency energy applied to a multicavity linear accelerator. In one application of the circuit two cavities are excited from a single radio frequency source, with one cavity directly coupled to the source and the other cavity coupled through a delay line of special construction. A phase detector provides a bipolar d-c output signal proportional to the difference in phase between the voltage in the two cavities. This d-c signal controls a bias supply which provides a d-c output for varying the capacitnce of voltage sensitive capacitors in the delay line. The over-all operation of the circuit is completely electronic, overcoming the time response limitations of the electromechanical control systems, and the relative phase relationship of the radio frequency voltages in the two caviiies is continuously controlled to effect particle acceleration.

  13. ELECTRONIC TRIGGER CIRCUIT

    DOEpatents

    Russell, J.A.G.

    1958-01-01

    An electronic trigger circuit is described of the type where an output pulse is obtained only after an input voltage has cqualed or exceeded a selected reference voltage. In general, the invention comprises a source of direct current reference voltage in series with an impedance and a diode rectifying element. An input pulse of preselected amplitude causes the diode to conduct and develop a signal across the impedance. The signal is delivered to an amplifier where an output pulse is produced and part of the output is fed back in a positive manner to the diode so that the amplifier produces a steep wave front trigger pulsc at the output. The trigger point of the described circuit is not subject to variation due to the aging, etc., of multi-electrode tabes, since the diode circuit essentially determines the trigger point.

  14. ELECTRONIC MULTIPLIER CIRCUIT

    DOEpatents

    Thomas, R.E.

    1959-08-25

    An electronic multiplier circuit is described in which an output voltage having an amplitude proportional to the product or quotient of the input signals is accomplished in a novel manner which facilitates simplicity of circuit construction and a high degree of accuracy in accomplishing the multiplying and dividing function. The circuit broadly comprises a multiplier tube in which the plate current is proportional to the voltage applied to a first control grid multiplied by the difference between voltage applied to a second control grid and the voltage applied to the first control grid. Means are provided to apply a first signal to be multiplied to the first control grid together with means for applying the sum of the first signal to be multiplied and a second signal to be multiplied to the second control grid whereby the plate current of the multiplier tube is proportional to the product of the first and second signals to be multiplied.

  15. Exploring Distributed Energy Alternatives to Electrical Distribution Grid Expansion in Souhern California Edison Service Territory

    SciTech Connect

    Stovall, Therese K; Kingston, Tim

    2005-12-01

    Distributed energy (DE) technologies have received much attention for the energy savings and electric power reliability assurances that may be achieved by their widespread adoption. Fueling the attention have been the desires to globally reduce greenhouse gas emissions and concern about easing power transmission and distribution system capacity limitations and congestion. However, these benefits may come at a cost to the electric utility companies in terms of lost revenue and concerns with interconnection on the distribution system. This study assesses the costs and benefits of DE to both consumers and distribution utilities and expands upon a precursory study done with Detroit Edison (DTE)1, by evaluating the combined impact of DE, energy-efficiency, photovoltaics (a use of solar energy), and demand response that will shape the grid of the future. This study was funded by the U.S. Department of Energy (DOE), Gas Research Institute (GRI), American Electric Power (AEP), and Gas Technology Institute's (GTI) Distributed Energy Collaborative Program (DECP). It focuses on two real Southern California Edison (SCE) circuits, a 13 MW suburban circuit fictitiously named Justice on the Lincoln substation, and an 8 MW rural circuit fictitiously named Prosper on the Washington Substation. The primary objectives of the study were threefold: (1) Evaluate the potential for using advanced energy technologies, including DE, energy-efficiency (EE), demand response, electricity storage, and photovoltaics (PV), to reshape electric load curves by reducing peak demand, for real circuits. (2) Investigate the potential impact on guiding technology deployment and managing operation in a way that benefits both utilities and their customers by: (a) Improving grid load factor for utilities; (b) Reducing energy costs for customers; and (c) Optimizing electric demand growth. (3) Demonstrate benefits by reporting on a recently installed advanced energy system at a utility customer site. This

  16. Electrical Circuit Tester

    DOEpatents

    Love, Frank

    2006-04-18

    An electrical circuit testing device is provided, comprising a case, a digital voltage level testing circuit with a display means, a switch to initiate measurement using the device, a non-shorting switching means for selecting pre-determined electrical wiring configurations to be tested in an outlet, a terminal block, a five-pole electrical plug mounted on the case surface and a set of adapters that can be used for various multiple-pronged electrical outlet configurations for voltages from 100 600 VAC from 50 100 Hz.

  17. Small circuits for cryptography.

    SciTech Connect

    Torgerson, Mark Dolan; Draelos, Timothy John; Schroeppel, Richard Crabtree; Miller, Russell D.; Anderson, William Erik

    2005-10-01

    This report examines a number of hardware circuit design issues associated with implementing certain functions in FPGA and ASIC technologies. Here we show circuit designs for AES and SHA-1 that have an extremely small hardware footprint, yet show reasonably good performance characteristics as compared to the state of the art designs found in the literature. Our AES performance numbers are fueled by an optimized composite field S-box design for the Stratix chipset. Our SHA-1 designs use register packing and feedback functionalities of the Stratix LE, which reduce the logic element usage by as much as 72% as compared to other SHA-1 designs.

  18. Terminal distribution of the corticospinal projection from the hand/arm region of the primary motor cortex to the cervical enlargement in rhesus monkey.

    PubMed

    Morecraft, Robert J; Ge, Jizhi; Stilwell-Morecraft, Kimberly S; McNeal, David W; Pizzimenti, Marc A; Darling, Warren G

    2013-12-15

    To further our understanding of the corticospinal projection (CSP) from the hand/arm representation of the primary motor cortex (M1), high-resolution anterograde tracing methodology and stereology were used to investigate the terminal distribution of this connection at spinal levels C5 to T1. The highest number of labeled terminal boutons occurred contralaterally (98%) with few ipsilaterally (2%). Contralaterally, labeled boutons were located within laminae I-X, with the densest distribution found in lamina VII and, to a lesser extent, laminae IX and VI. Fewer terminals were found in other contralateral laminae. Within lamina VII, terminal boutons were most prominent in the dorsomedial, dorsolateral, and ventrolateral subsectors. Within lamina IX, the heaviest terminal labeling was distributed dorsally. Ipsilaterally, boutons were found in laminae V-X. The most pronounced distribution occurred in the dorsomedial and ventromedial sectors of lamina VII and fewer labeled boutons were located in other ipsilateral laminae. Segmentally, contralateral lamina VII labeling was highest at levels C5-C7. In contrast, lamina IX labeling was highest at C7-T1 and more widely dispersed among the quadrants at C8-T1. Our findings suggest dominant contralateral influence of the M1 hand/arm CSP, a contralateral innervation pattern in lamina VII supporting Kuypers (1982) conceptual framework of a "lateral motor system," and a projection to lamina IX indicating significant influence on motoneurons innervating flexors acting on the shoulder and elbow rostrally (C5-C7), along with flexors, extensors, abductors and adductors acting on the digits, hand and wrist caudally (C8-T1).

  19. Sea ice and primary production proxies in surface sediments from a High Arctic Greenland fjord: Spatial distribution and implications for palaeoenvironmental studies.

    PubMed

    Ribeiro, Sofia; Sejr, Mikael K; Limoges, Audrey; Heikkilä, Maija; Andersen, Thorbjørn Joest; Tallberg, Petra; Weckström, Kaarina; Husum, Katrine; Forwick, Matthias; Dalsgaard, Tage; Massé, Guillaume; Seidenkrantz, Marit-Solveig; Rysgaard, Søren

    2017-02-01

    In order to establish a baseline for proxy-based reconstructions for the Young Sound-Tyrolerfjord system (Northeast Greenland), we analysed the spatial distribution of primary production and sea ice proxies in surface sediments from the fjord, against monitoring data from the Greenland Ecosystem Monitoring Programme. Clear spatial gradients in organic carbon and biogenic silica contents reflected marine influence, nutrient availability and river-induced turbidity, in good agreement with in situ measurements. The sea ice proxy IP25 was detected at all sites but at low concentrations, indicating that IP25 records from fjords need to be carefully considered and not directly compared to marine settings. The sea ice-associated biomarker HBI III revealed an open-water signature, with highest concentrations near the mid-July ice edge. This proxy evaluation is an important step towards reliable palaeoenvironmental reconstructions that will, ultimately, contribute to better predictions for this High Arctic ecosystem in a warming climate.

  20. Monte Carlo simulation of electron depth distribution and backscattering for carbon films deposited on aluminium as a function of incidence angle and primary energy

    NASA Astrophysics Data System (ADS)

    Dapor, Maurizio

    2005-01-01

    Carbon films are deposited on various substrates (polymers, polyester fabrics, polyester yarns, metal alloys) both for experimental and technological motivations (medical devices, biocompatible coatings, food package and so on). Computational studies of the penetration of electron beams in supported thin film of carbon are very useful in order to compare the simulated results with analytical techniques data (obtained by scanning electron microscopy and/or Auger electron spectroscopy) and investigate the film characteristics. In the present paper, the few keV electron depth distribution and backscattering coefficient for the special case of film of carbon deposited on aluminium are investigated, by a Monte Carlo simulation, as a function of the incidence angle and primary electron energy. The simulated results can be used as a way to evaluate the carbon film thickness by a set of measurements of the backscattering coefficient.

  1. Operational research in primary health care planning: a theoretical model for estimating the coverage achieved by different distributions of staff and facilities

    PubMed Central

    Kemball-Cook, D.; Vaughan, J. P.

    1983-01-01

    This report outlines a basic operational research model for estimating the coverage achieved by different distributions of primary health care staff and facilities, using antenatal home visiting as an illustrative example. Coverage is estimated in terms of the average number of patient contacts achieved per annum. The model takes into account such features as number of facilities and health workers per 10 000 population, the radius of the health facility area, the overall population density in the region, the number of working days in the year, and the health worker's travelling time and work rate. A theoretical planning situation is also presented, showing the application of the model in defining various possible strategies, using certain planning norms for new levels of staff and facilities. This theoretical model is presented as an example of the use of operational research in primary health care, but it requires to be tested and validated in known situations before its usefulness can be assessed. Some indications are given of the ways in which the model could be adapted and improved for application to a real planning situation. PMID:6602666

  2. Parallelism in integrated fluidic circuits

    NASA Astrophysics Data System (ADS)

    Bousse, Luc J.; Kopf-Sill, Anne R.; Parce, J. W.

    1998-04-01

    Many research groups around the world are working on integrated microfluidics. The goal of these projects is to automate and integrate the handling of liquid samples and reagents for measurement and assay procedures in chemistry and biology. Ultimately, it is hoped that this will lead to a revolution in chemical and biological procedures similar to that caused in electronics by the invention of the integrated circuit. The optimal size scale of channels for liquid flow is determined by basic constraints to be somewhere between 10 and 100 micrometers . In larger channels, mixing by diffusion takes too long; in smaller channels, the number of molecules present is so low it makes detection difficult. At Caliper, we are making fluidic systems in glass chips with channels in this size range, based on electroosmotic flow, and fluorescence detection. One application of this technology is rapid assays for drug screening, such as enzyme assays and binding assays. A further challenge in this area is to perform multiple functions on a chip in parallel, without a large increase in the number of inputs and outputs. A first step in this direction is a fluidic serial-to-parallel converter. Fluidic circuits will be shown with the ability to distribute an incoming serial sample stream to multiple parallel channels.

  3. Circuit for Communication Over Power Lines

    NASA Technical Reports Server (NTRS)

    Krasowski, Michael J.; Prokop, Normal F.; Greer, Lawrence C., III; Nappier, Jennifer

    2011-01-01

    Many distributed systems share common sensors and instruments along with a common power line supplying current to the system. A communication technique and circuit has been developed that allows for the simple inclusion of an instrument, sensor, or actuator node within any system containing a common power bus. Wherever power is available, a node can be added, which can then draw power for itself, its associated sensors, and actuators from the power bus all while communicating with other nodes on the power bus. The technique modulates a DC power bus through capacitive coupling using on-off keying (OOK), and receives and demodulates the signal from the DC power bus through the same capacitive coupling. The circuit acts as serial modem for the physical power line communication. The circuit and technique can be made of commercially available components or included in an application specific integrated circuit (ASIC) design, which allows for the circuit to be included in current designs with additional circuitry or embedded into new designs. This device and technique moves computational, sensing, and actuation abilities closer to the source, and allows for the networking of multiple similar nodes to each other and to a central processor. This technique also allows for reconfigurable systems by adding or removing nodes at any time. It can do so using nothing more than the in situ power wiring of the system.

  4. 30 CFR 77.803-1 - Fail safe ground check circuits; maximum voltage.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Fail safe ground check circuits; maximum... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.803-1 Fail safe ground check circuits; maximum voltage. The maximum voltage used for ground check circuits under § 77.803 shall...

  5. 30 CFR 77.803-1 - Fail safe ground check circuits; maximum voltage.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Fail safe ground check circuits; maximum... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.803-1 Fail safe ground check circuits; maximum voltage. The maximum voltage used for ground check circuits under § 77.803 shall...

  6. 30 CFR 77.803-1 - Fail safe ground check circuits; maximum voltage.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Fail safe ground check circuits; maximum... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.803-1 Fail safe ground check circuits; maximum voltage. The maximum voltage used for ground check circuits under § 77.803 shall...

  7. 30 CFR 77.803-1 - Fail safe ground check circuits; maximum voltage.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Fail safe ground check circuits; maximum... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.803-1 Fail safe ground check circuits; maximum voltage. The maximum voltage used for ground check circuits under § 77.803 shall...

  8. 30 CFR 77.803-1 - Fail safe ground check circuits; maximum voltage.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Fail safe ground check circuits; maximum... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.803-1 Fail safe ground check circuits; maximum voltage. The maximum voltage used for ground check circuits under § 77.803 shall...

  9. Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans

    PubMed Central

    Leinwand, Sarah G.; Chalasani, Sreekanth H.

    2013-01-01

    Neural circuits detect environmental changes and drive behavior. The routes of information flow through dense neural networks are dynamic; however, the mechanisms underlying this circuit flexibility are poorly understood. Here, we define a novel, sensory context-dependent and neuropeptide-regulated switch in the composition of a C. elegans salt sensory circuit. The primary salt detectors, ASE sensory neurons, use BLI-4 endoprotease-dependent cleavage to release the insulin-like peptide INS-6 in response to large but not small changes in external salt stimuli. Insulins, signaling through the insulin receptor DAF-2, functionally switch the AWC olfactory sensory neuron into an interneuron in the salt circuit. Animals with disrupted insulin signaling have deficits in salt attraction, suggesting that peptidergic signaling potentiates responses to high salt stimuli, which may promote ion homeostasis. Our results show that sensory context and neuropeptide signaling modify neural networks and suggest general mechanisms for generating flexible behavioral outputs by modulating neural circuit composition. PMID:24013594

  10. Integrated circuit reliability testing

    NASA Technical Reports Server (NTRS)

    Buehler, Martin G. (Inventor); Sayah, Hoshyar R. (Inventor)

    1990-01-01

    A technique is described for use in determining the reliability of microscopic conductors deposited on an uneven surface of an integrated circuit device. A wafer containing integrated circuit chips is formed with a test area having regions of different heights. At the time the conductors are formed on the chip areas of the wafer, an elongated serpentine assay conductor is deposited on the test area so the assay conductor extends over multiple steps between regions of different heights. Also, a first test conductor is deposited in the test area upon a uniform region of first height, and a second test conductor is deposited in the test area upon a uniform region of second height. The occurrence of high resistances at the steps between regions of different height is indicated by deriving the measured length of the serpentine conductor using the resistance measured between the ends of the serpentine conductor, and comparing that to the design length of the serpentine conductor. The percentage by which the measured length exceeds the design length, at which the integrated circuit will be discarded, depends on the required reliability of the integrated circuit.

  11. Integrated circuit reliability testing

    NASA Technical Reports Server (NTRS)

    Buehler, Martin G. (Inventor); Sayah, Hoshyar R. (Inventor)

    1988-01-01

    A technique is described for use in determining the reliability of microscopic conductors deposited on an uneven surface of an integrated circuit device. A wafer containing integrated circuit chips is formed with a test area having regions of different heights. At the time the conductors are formed on the chip areas of the wafer, an elongated serpentine assay conductor is deposited on the test area so the assay conductor extends over multiple steps between regions of different heights. Also, a first test conductor is deposited in the test area upon a uniform region of first height, and a second test conductor is deposited in the test area upon a uniform region of second height. The occurrence of high resistances at the steps between regions of different height is indicated by deriving the measured length of the serpentine conductor using the resistance measured between the ends of the serpentine conductor, and comparing that to the design length of the serpentine conductor. The percentage by which the measured length exceeds the design length, at which the integrated circuit will be discarded, depends on the required reliability of the integrated circuit.

  12. An atomtronic dumbell circuit

    NASA Astrophysics Data System (ADS)

    Li, Aijun; Murray, N.; Lanier, C.; Wang, Y.-H.; Clark, C. W.; Edwards, M.

    2014-05-01

    We report on simulations of the behavior of a Bose-Einstein condensate formed in the left well of a ``dumbell'' circuit potential. This quasi-2d potential takes the form of the combination of strong harmonic vertical confinement along with a horizontal-plane potential having dumbell shape. The dumbell consists of two circular wells connected by a channel. We assume that the condensate is initially formed in one of the wells and then is released and allowed to flow down the channel into the other well and possibly back again. We first simulated the behavior of the BEC in this potential using a variational mean-field version of the 3D Gross-Pitaevskii equation (GPE) at zero temperature for dumbell potentials having a range of different channel lengths and widths. We used these results to indentify equivalent ``atomtronic'' circuits such as an RCL circuit with DC battery. We also investigated the effects of finite temperature on the behavior of the condensate in the dumbell potential using the Zaremba-Nikuni-Griffin (ZNG) theory. These results were used to identify the effects of a thermal cloud on the atomtronic circuit operation. Supported in part by NSF grant #1068761 and ARO Atomtronics MURI.

  13. Wein bridge oscillator circuit

    NASA Technical Reports Server (NTRS)

    Lipoma, P. C.

    1971-01-01

    Circuit with minimum number of components provides stable outputs of 2 to 8 volts at frequencies of .001 to 100 kHz. Oscillator exhibits low power consumption, portability, simplicity, and drive capability, it has application as loudspeaker tester and audible alarm, as well as in laboratory and test generators.

  14. Circuit breaker lockout device

    DOEpatents

    Kozlowski, Lawrence J.; Shirey, Lawrence A.

    1992-01-01

    An improved lockout assembly for locking a circuit breaker in a selected off or on position is provided. The lockout assembly includes a lock block and a lock pin. The lock block has a hollow interior which fits over the free end of a switch handle of the circuit breaker. The lock block includes at least one hole that is placed in registration with a hole in the free end of the switch handle. A lock tab on the lock block serves to align and register the respective holes on the lock block and switch handle. A lock pin is inserted through the registered holes and serves to connect the lock block to the switch handle. Once the lock block and the switch handle are connected, the position of the switch handle is prevented from being changed by the lock tab bumping up against a stationary housing portion of the circuit breaker. When the lock pin installed, an apertured-end portion of the lock pin is in registration with another hole on the lock block. Then a special scissors conforming to O.S.H.A. regulations can be installed, with one or more padlocks, on the lockout assembly to prevent removal of the lock pin from the lockout assembly, thereby preventing removal of the lockout assembly from the circuit breaker.

  15. Circuit breaker lockout device

    DOEpatents

    Kozlowski, L.J.; Shirey, L.A.

    1992-11-24

    An improved lockout assembly for locking a circuit breaker in a selected off or on position is provided. The lockout assembly includes a lock block and a lock pin. The lock block has a hollow interior which fits over the free end of a switch handle of the circuit breaker. The lock block includes at least one hole that is placed in registration with a hole in the free end of the switch handle. A lock tab on the lock block serves to align and register the respective holes on the lock block and switch handle. A lock pin is inserted through the registered holes and serves to connect the lock block to the switch handle. Once the lock block and the switch handle are connected, the position of the switch handle is prevented from being changed by the lock tab bumping up against a stationary housing portion of the circuit breaker. When the lock pin installed, an apertured-end portion of the lock pin is in registration with another hole on the lock block. Then a special scissors conforming to O.S.H.A. regulations can be installed, with one or more padlocks, on the lockout assembly to prevent removal of the lock pin from the lockout assembly, thereby preventing removal of the lockout assembly from the circuit breaker. 2 figs.

  16. Bioluminescent bioreporter integrated circuit

    DOEpatents

    Simpson, Michael L.; Sayler, Gary S.; Paulus, Michael J.

    2000-01-01

    Disclosed are monolithic bioelectronic devices comprising a bioreporter and an OASIC. These bioluminescent bioreporter integrated circuit are useful in detecting substances such as pollutants, explosives, and heavy-metals residing in inhospitable areas such as groundwater, industrial process vessels, and battlefields. Also disclosed are methods and apparatus for environmental pollutant detection, oil exploration, drug discovery, industrial process control, and hazardous chemical monitoring.

  17. A Step Circuit Program.

    ERIC Educational Resources Information Center

    Herman, Susan

    1995-01-01

    Aerobics instructors can use step aerobics to motivate students. One creative method is to add the step to the circuit workout. By incorporating the step, aerobic instructors can accommodate various fitness levels. The article explains necessary equipment and procedures, describing sample stations for cardiorespiratory fitness, muscular strength,…

  18. A Magnetic Circuit Demonstration.

    ERIC Educational Resources Information Center

    Vanderkooy, John; Lowe, June

    1995-01-01

    Presents a demonstration designed to illustrate Faraday's, Ampere's, and Lenz's laws and to reinforce the concepts through the analysis of a two-loop magnetic circuit. Can be made dramatic and challenging for sophisticated students but is suitable for an introductory course in electricity and magnetism. (JRH)

  19. Field circuit breaker tester

    NASA Astrophysics Data System (ADS)

    Fulcomer, P. M.

    1982-05-01

    Test equipment developed at National Bureau of Standards (NBS) for the Consumer Product Safety Commission (CPSC) to evaluate the performance of single-pole circuit breakers in residential installations is described along with instructions for its use. The procedures are intended to be carried out by a test crew of at least two persons.

  20. "Printed-circuit" rectenna

    NASA Technical Reports Server (NTRS)

    Dickinson, R. M.

    1977-01-01

    Rectifying antenna is less bulky structure for absorbing transmitted microwave power and converting it into electrical current. Printed-circuit approach, using microstrip technology and circularly polarized antenna, makes polarization orientation unimportant and allows much smaller arrays for given performance. Innovation is particularly useful with proposed electric vehicles powered by beam microwaves.

  1. Electrifying Inquiry: Electrical Circuits

    ERIC Educational Resources Information Center

    Godbey, Susan; Barnett, Jessica; Webster, Lois

    2005-01-01

    An activity involving parallel electrical circuits was modified to incorporate an open inquiry approach. Both the original and revised versions of the activity were tested in the middle school classroom. We present a comparison of the two versions of the activity in terms of facilitating learning and engaging students' interests.

  2. Resistor Combinations for Parallel Circuits.

    ERIC Educational Resources Information Center

    McTernan, James P.

    1978-01-01

    To help simplify both teaching and learning of parallel circuits, a high school electricity/electronics teacher presents and illustrates the use of tables of values for parallel resistive circuits in which total resistances are whole numbers. (MF)

  3. Electronic circuits and systems: A compilation. [including integrated circuits, logic circuits, varactor diode circuits, low pass filters, and optical equipment circuits

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Technological information is presented electronic circuits and systems which have potential utility outside the aerospace community. Topics discussed include circuit components such as filters, converters, and integrators, circuits designed for use with specific equipment or systems, and circuits designed primarily for use with optical equipment or displays.

  4. Methods of fabricating applique circuits

    DOEpatents

    Dimos, Duane B.; Garino, Terry J.

    1999-09-14

    Applique circuits suitable for advanced packaging applications are introduced. These structures are particularly suited for the simple integration of large amounts (many nanoFarads) of capacitance into conventional integrated circuit and multichip packaging technology. In operation, applique circuits are bonded to the integrated circuit or other appropriate structure at the point where the capacitance is required, thereby minimizing the effects of parasitic coupling. An immediate application is to problems of noise reduction and control in modern high-frequency circuitry.

  5. Statistical circuit design for yield improvement in CMOS circuits

    NASA Technical Reports Server (NTRS)

    Kamath, H. J.; Purviance, J. E.; Whitaker, S. R.

    1990-01-01

    This paper addresses the statistical design of CMOS integrated circuits for improved parametric yield. The work uses the Monte Carlo technique of circuit simulation to obtain an unbiased estimation of the yield. A simple graphical analysis tool, the yield factor histogram, is presented. The yield factor histograms are generated by a new computer program called SPICENTER. Using the yield factor histograms, the most sensitive circuit parameters are noted, and their nominal values are changed to improve the yield. Two basic CMOS example circuits, one analog and one digital, are chosen and their designs are 'centered' to illustrate the use of the yield factor histograms for statistical circuit design.

  6. Ladder-Type Circuits Revisited

    ERIC Educational Resources Information Center

    Yoon, Sung Hyun

    2007-01-01

    Ladder-type circuits where a given unit is repeated infinitely many times are dealt with in many textbooks on electromagnetism as examples of filter circuits. Determining the impedance of such circuits seems to be regarded as simple, which may be due to the fact that the invariance of the infinite system under the operation of adding one more unit…

  7. High voltage MOSFET switching circuit

    DOEpatents

    McEwan, T.E.

    1994-07-26

    The problem of source lead inductance in a MOSFET switching circuit is compensated for by adding an inductor to the gate circuit. The gate circuit inductor produces an inductive spike which counters the source lead inductive drop to produce a rectangular drive voltage waveform at the internal gate-source terminals of the MOSFET. 2 figs.

  8. High voltage MOSFET switching circuit

    DOEpatents

    McEwan, Thomas E.

    1994-01-01

    The problem of source lead inductance in a MOSFET switching circuit is compensated for by adding an inductor to the gate circuit. The gate circuit inductor produces an inductive spike which counters the source lead inductive drop to produce a rectangular drive voltage waveform at the internal gate-source terminals of the MOSFET.

  9. Selective Manipulation of Neural Circuits.

    PubMed

    Park, Hong Geun; Carmel, Jason B

    2016-04-01

    Unraveling the complex network of neural circuits that form the nervous system demands tools that can manipulate specific circuits. The recent evolution of genetic tools to target neural circuits allows an unprecedented precision in elucidating their function. Here we describe two general approaches for achieving circuit specificity. The first uses the genetic identity of a cell, such as a transcription factor unique to a circuit, to drive expression of a molecule that can manipulate cell function. The second uses the spatial connectivity of a circuit to achieve specificity: one genetic element is introduced at the origin of a circuit and the other at its termination. When the two genetic elements combine within a neuron, they can alter its function. These two general approaches can be combined to allow manipulation of neurons with a specific genetic identity by introducing a regulatory gene into the origin or termination of the circuit. We consider the advantages and disadvantages of both these general approaches with regard to specificity and efficacy of the manipulations. We also review the genetic techniques that allow gain- and loss-of-function within specific neural circuits. These approaches introduce light-sensitive channels (optogenetic) or drug sensitive channels (chemogenetic) into neurons that form specific circuits. We compare these tools with others developed for circuit-specific manipulation and describe the advantages of each. Finally, we discuss how these tools might be applied for identification of the neural circuits that mediate behavior and for repair of neural connections.

  10. Neuromorphic Silicon Neuron Circuits

    PubMed Central

    Indiveri, Giacomo; Linares-Barranco, Bernabé; Hamilton, Tara Julia; van Schaik, André; Etienne-Cummings, Ralph; Delbruck, Tobi; Liu, Shih-Chii; Dudek, Piotr; Häfliger, Philipp; Renaud, Sylvie; Schemmel, Johannes; Cauwenberghs, Gert; Arthur, John; Hynna, Kai; Folowosele, Fopefolu; Saighi, Sylvain; Serrano-Gotarredona, Teresa; Wijekoon, Jayawan; Wang, Yingxue; Boahen, Kwabena

    2011-01-01

    Hardware implementations of spiking neurons can be extremely useful for a large variety of applications, ranging from high-speed modeling of large-scale neural systems to real-time behaving systems, to bidirectional brain–machine interfaces. The specific circuit solutions used to implement silicon neurons depend on the application requirements. In this paper we describe the most common building blocks and techniques used to implement these circuits, and present an overview of a wide range of neuromorphic silicon neurons, which implement different computational models, ranging from biophysically realistic and conductance-based Hodgkin–Huxley models to bi-dimensional generalized adaptive integrate and fire models. We compare the different design methodologies used for each silicon neuron design described, and demonstrate their features with experimental results, measured from a wide range of fabricated VLSI chips. PMID:21747754

  11. PHASE DIFFERENTIAL INDICATING CIRCUIT

    DOEpatents

    Kirsten, F.A.

    1962-01-01

    An electronic circuit for totalizing the net phase difference between two alternating current signals is designed which responds to both increasing and decreasing phase changes. A phase comparator provldes an output pulse for each 360 deg of phase difference occurring, there being a negative pulse for phase shtft in one direction and a positive pulse for a phase shift in the opposite direction. A counting circuit utilizing glow discharge tubes receives the negative and positive pulses at a single input terminal and provides a running net total, pulses of one polarity dded and pulses of the opposite polarity being subtracted. The glow discharge tubes may be decaded to increase the total count capacity. (AEC)

  12. Power supply conditioning circuit

    NASA Technical Reports Server (NTRS)

    Primas, L. E.; Loveland, R.

    1987-01-01

    A power supply conditioning circuit that can reduce Periodic and Random Deviations (PARD) on the output voltages of dc power supplies to -150 dBV from dc to several KHz with no measurable periodic deviations is described. The PARD for a typical commercial low noise power supply is -74 dBV for frequencies above 20 Hz and is often much worse at frequencies below 20 Hz. The power supply conditioning circuit described here relies on the large differences in the dynamic impedances of a constant current diode and a zener diode to establish a dc voltage with low PARD. Power supplies with low PARD are especially important in circuitry involving ultrastable frequencies for the Deep Space Network.

  13. GAS PHOTOTUBE CIRCUIT

    DOEpatents

    Richardson, J.H.

    1958-03-01

    This patent pertains to electronic circuits for measuring the intensity of light and is especially concerned with measurement between preset light thresholds. Such a circuit has application in connection with devices for reading-out information stored on punch cards or tapes where the cards and tapes are translucent. By the novel arrangement of this invention thc sensitivity of a gas phototube is maintained at a low value when the light intensity is below a first threshold level. If the light level rises above the first threshold level, the tube is rendered highly sensitive and an output signal will vary in proportion to the light intensity change. When the light level decreases below a second threshold level, the gas phototube is automatically rendered highly insensitive. Each of these threshold points is adjustable.

  14. Preconditioner Circuit Analysis

    DTIC Science & Technology

    2011-09-01

    ground plane and both operational amplifier terminals. The parasitic capacitances are labeled Cp1 and Cp2 in Figure 19. Figure 19. Circuit for...3.69 MHz 3.98pF 55720 5107 OV                                  (17) Cp2 = 1 pF R1 = 5107 Ω R3...circuit. The capacitor would be placed in parallel with RF to cancel the effect of Cp2 and then feedback factor will look purely resistive. Another

  15. Integrated Circuit Immunity

    NASA Technical Reports Server (NTRS)

    Sketoe, J. G.; Clark, Anthony

    2000-01-01

    This paper presents a DOD E3 program overview on integrated circuit immunity. The topics include: 1) EMI Immunity Testing; 2) Threshold Definition; 3) Bias Tee Function; 4) Bias Tee Calibration Set-Up; 5) EDM Test Figure; 6) EMI Immunity Levels; 7) NAND vs. and Gate Immunity; 8) TTL vs. LS Immunity Levels; 9) TP vs. OC Immunity Levels; 10) 7805 Volt Reg Immunity; and 11) Seventies Chip Set. This paper is presented in viewgraph form.

  16. Monolithic Optoelectronic Integrated Circuit

    NASA Technical Reports Server (NTRS)

    Bhasin, Kul B.; Walters, Wayne; Gustafsen, Jerry; Bendett, Mark

    1990-01-01

    Monolithic optoelectronic integrated circuit (OEIC) receives single digitally modulated input light signal via optical fiber and converts it into 16-channel electrical output signal. Potentially useful in any system in which digital data must be transmitted serially at high rates, then decoded into and used in parallel format at destination. Applications include transmission and decoding of control signals to phase shifters in phased-array antennas and also communication of data between computers and peripheral equipment in local-area networks.

  17. Cartography of serotonergic circuits.

    PubMed

    Sparta, Dennis R; Stuber, Garret D

    2014-08-06

    Serotonin is an essential neuromodulator, but the precise circuit connectivity that regulates serotonergic neurons has not been well defined. Using rabies virus tracing strategies Weissbourd et al. (2014) and Pollak Dorocic et al. (2014) in this issue of Neuron and Ogawa et al. (2014) in Cell Reports provide a comprehensive map of the inputs to serotonergic neurons, highlighting the complexity and diversity of potential upstream cellular regulators.

  18. PARTICLE BEAM TRACKING CIRCUIT

    DOEpatents

    Anderson, O.A.

    1959-05-01

    >A particle-beam tracking and correcting circuit is described. Beam induction electrodes are placed on either side of the beam, and potentials induced by the beam are compared in a voltage comparator or discriminator. This comparison produces an error signal which modifies the fm curve at the voltage applied to the drift tube, thereby returning the orbit to the preferred position. The arrangement serves also to synchronize accelerating frequency and magnetic field growth. (T.R.H.)

  19. Driven superconducting quantum circuits

    NASA Astrophysics Data System (ADS)

    Nakamura, Yasunobu

    2014-03-01

    Driven nonlinear quantum systems show rich phenomena in various fields of physics. Among them, superconducting quantum circuits have very attractive features such as well-controlled quantum states with design flexibility, strong nonlinearity of Josephson junctions, strong coupling to electromagnetic driving fields, little internal dissipation, and tailored coupling to the electromagnetic environment. We have investigated properties and functionalities of driven superconducting quantum circuits. A transmon qubit coupled to a transmission line shows nearly perfect spatial mode matching between the incident and scattered microwave field in the 1D mode. Dressed states under a driving field are studied there and also in a semi-infinite 1D mode terminated by a resonator containing a flux qubit. An effective Λ-type three-level system is realized under an appropriate driving condition. It allows ``impedance-matched'' perfect absorption of incident probe photons and down conversion into another frequency mode. Finally, the weak signal from the qubit is read out using a Josephson parametric amplifier/oscillator which is another nonlinear circuit driven by a strong pump field. This work was partly supported by the Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST), Project for Developing Innovation Systems of MEXT, MEXT KAKENHI ``Quantum Cybernetics,'' and the NICT Commissioned Research.

  20. Digital integrated circuits

    NASA Astrophysics Data System (ADS)

    Polasek, P.; Halamik, J.

    1984-05-01

    The term semicustom designed integrated circuits denotes integrated circuits of an all purpose character in which the production of chips is completed by using one to three custom design stencil type exposure masks. This involves in most cases interconnecting masks that are used to devise the circuit function desired by the customer. Silicon plates with an all purpose gate matrix are produced up to the interconnection level and can be kept at this phase in storage, after which a customer's specific demands can be met very expediently. All purpose logic fields containing 200 logic gates on a chip and an all purpose chip to be expanded to 1,000 logic gates are discussed. The technology facilitates the devising of fast gates with a delay of approximately 5 ns and power dissipation of 1 mW. In assembly it will be possible to make use of the entire assortment of the currently used casings with 16, 18, 20, 24, 28 and 40 outlets. In addition to the development of the mentioned technology, a general methodology for design of the mentioned gate fields is currently under way.

  1. Optical Circuit Switched Protocol

    NASA Technical Reports Server (NTRS)

    Monacos, Steve P. (Inventor)

    2000-01-01

    The present invention is a system and method embodied in an optical circuit switched protocol for the transmission of data through a network. The optical circuit switched protocol is an all-optical circuit switched network and includes novel optical switching nodes for transmitting optical data packets within a network. Each optical switching node comprises a detector for receiving the header, header detection logic for translating the header into routing information and eliminating the header, and a controller for receiving the routing information and configuring an all optical path within the node. The all optical path located within the node is solely an optical path without having electronic storage of the data and without having optical delay of the data. Since electronic storage of the header is not necessary and the initial header is eliminated by the first detector of the first switching node. multiple identical headers are sent throughout the network so that subsequent switching nodes can receive and read the header for setting up an optical data path.

  2. Inkjet deposited circuit components

    NASA Astrophysics Data System (ADS)

    Bidoki, S. M.; Nouri, J.; Heidari, A. A.

    2010-05-01

    All-printed electronics as a means of achieving ultra-low-cost electronic circuits has attracted great interest in recent years. Inkjet printing is one of the most promising techniques by which the circuit components can be ultimately drawn (i.e. printed) onto the substrate in one step. Here, the inkjet printing technique was used to chemically deposit silver nanoparticles (10-200 nm) simply by ejection of silver nitrate and reducing solutions onto different substrates such as paper, PET plastic film and textile fabrics. The silver patterns were tested for their functionality to work as circuit components like conductor, resistor, capacitor and inductor. Different levels of conductivity were achieved simply by changing the printing sequence, inks ratio and concentration. The highest level of conductivity achieved by an office thermal inkjet printer (300 dpi) was 5.54 × 105 S m-1 on paper. Inkjet deposited capacitors could exhibit a capacitance of more than 1.5 nF (parallel plate 45 × 45 mm2) and induction coils displayed an inductance of around 400 µH (planar coil 10 cm in diameter). Comparison of electronic performance of inkjet deposited components to the performance of conventionally etched items makes the technique highly promising for fabricating different printed electronic devices.

  3. Interface Circuit For Printer Port

    NASA Technical Reports Server (NTRS)

    Tucker, Jerry H.; Yadlowsky, Ann B.

    1991-01-01

    Electronic circuit, called printer-port interface circuit (PPI) developed to overcome certain disadvantages of previous methods for connecting IBM PC or PC-compatible computer to other equipment. Has both reading and writing modes of operation. Very simple, requiring only six integrated circuits. Provides for moderately fast rates of transfer of data and uses existing unmodified circuit card in IBM PC. When used with appropriate software, circuit converts printer port on IBM PC, XT, AT, or compatible personal computer to general purpose, 8-bit-data, 16-bit address bus that connects to multitude of devices.

  4. Coating Circuit Boards With Silicone

    NASA Technical Reports Server (NTRS)

    Gaudiano, S.

    1986-01-01

    Techniques appropriate to boards containing CMOS circuits detailed. Document presents procedure for applying thin conformal coating to such electronic assemblies as printed-circuit boards and wire-wrapped boards. Coating is from 1 to 7 mils (25 to 178 micrometers) thick and composed of room-temperature-vulcanizing (RTV) silicone. Specifies materials, equipment, spraying method, and quality requirements. Takes into account special needs of circuits made with complementary metal-oxide/semiconductor (CMOS) devices on circuit boards. Special attention given to preventing damage by electrostatic discharge, to which CMOS circuits especially sensitive.

  5. Power system with an integrated lubrication circuit

    SciTech Connect

    Hoff, Brian D.; Akasam, Sivaprasad; Algrain, Marcelo C.; Johnson, Kris W.; Lane, William H.

    2009-11-10

    A power system includes an engine having a first lubrication circuit and at least one auxiliary power unit having a second lubrication circuit. The first lubrication circuit is in fluid communication with the second lubrication circuit.

  6. Climate change and its impacts on vegetation distribution and net primary productivity of the alpine ecosystem in the Qinghai-Tibetan Plateau.

    PubMed

    Gao, Qingzhu; Guo, Yaqi; Xu, Hongmei; Ganjurjav, Hasbagen; Li, Yue; Wan, Yunfan; Qin, Xiaobo; Ma, Xin; Liu, Shuo

    2016-06-01

    Changes in climate have caused impacts on ecosystems on all continents scale, and climate change is also projected to be a stressor on most ecosystems even at the rate of low- to medium-range warming scenarios. Alpine ecosystem in the Qinghai-Tibetan Plateau is vulnerable to climate change. To quantify the climate change impacts on alpine ecosystems, we simulated the vegetation distribution and net primary production in the Qinghai-Tibetan Plateau for three future periods (2020s, 2050s and 2080s) using climate projection for RCPs (Representative Concentration Pathways) RCP4.5 and RCP8.5 scenarios. The modified Lund-Potsdam-Jena Dynamic Global Vegetation Model (LPJ model) was parameter and test to make it applicable to the Qinghai-Tibetan Plateau. Climate projections that were applied to LPJ model in the Qinghai-Tibetan Plateau showed trends toward warmer and wetter conditions. Results based on climate projections indicated changes from 1.3°C to 4.2°C in annual temperature and changes from 2% to 5% in annual precipitation. The main impacts on vegetation distribution was increase in the area of forests and shrubs, decrease in alpine meadows which mainly replaced by shrubs which dominated the eastern plateau, and expanding in alpine steppes to the northwest dominated the western and northern plateau. The NPP was projected to increase by 79% and 134% under the RCP4.5 and RCP8.5. The projected NPP generally increased about 200gC·m(-2)·yr(-1) in most parts of the plateau with a gradual increase from the eastern to the western region of the Qinghai-Tibetan Plateau at the end of this century.

  7. Teaching Electricity Effectively in the Primary School: A Case Study.

    ERIC Educational Resources Information Center

    Summers, Mike; Kruger, Colin; Mant, Jenny

    1998-01-01

    Identifies subject and teaching knowledge that primary school teachers can use to effectively develop children's understanding of electricity and simple circuits. Presents a set of electricity concepts that are appropriate for primary children to explore. Contains 19 references. (DDR)

  8. The Protective Effect of Icariin on Mitochondrial Transport and Distribution in Primary Hippocampal Neurons from 3× Tg-AD Mice.

    PubMed

    Chen, Yijing; Han, Shuangxue; Huang, Xiuxian; Ni, Jiazuan; He, Xiaoyang

    2016-01-27

    Icariin, a pharmacologically active component isolated from the Chinese herb Epimedium, has been shown to improve spatial learning and memory abilities in Alzheimer's disease (AD) rats through inhibition of Aβ production and tau protein hyperphosphorylation. However, the potential mechanism of icariin-induced protective effects against mitochondrial dysfunctions in AD still remains unclear. In the present study, we investigated the effect of icariin on the modulation of mitochondrial transport and distribution in primary hippocampal cultures from triple-transgenic (3× Tg) AD mice. The results showed that icariin enhanced mitochondrial motility and increased mitochondrial index and mitochondrial length and size in the diseased neurons. Additionally, the expression of the key mitochondrial enzyme, pyruvate dehydrogenase-E1α (PDHE1α), and the post synaptic density protein 95 (PSD95), was preserved in AD neurons after icariin treatment, accompanied by a downregulation of Aβ and phosphorylated tau expression in the corresponding areas. Further study showed that icariin treatment resulted in a decrease in mitochondrial fission protein dynamin-related protein 1 (Drp1) and an increase in fusion protein Mitofusin 2 (Mfn2). These data indicate that icariin can promote mitochondrial transport, protect mitochondria against fragmentation and preserve the expression of mitochondrial and synaptic functional proteins in AD neurons. Thus, icariin may be a potential therapeutic complement for AD and other mitochondrial malfunction-related neuronal degenerative diseases.

  9. Establishing the Relationship between Fracture-Related Dolomite and Primary Rock Fabric on the Distribution of Reservoirs in the Michigan Basin

    SciTech Connect

    G. Michael Grammer

    2006-09-30

    This topical report covers the year 2 of the subject 3-year grant, evaluating the relationship between fracture-related dolomite and dolomite constrained by primary rock fabric in the 3 most prolific reservoir intervals in the Michigan Basin (Ordovician Trenton-Black River Formations; Silurian Niagara Group; and the Devonian Dundee Formation). The characterization of select dolomite reservoirs has been the major focus of our efforts in Phase II/Year 2. Fields have been prioritized based upon the availability of rock data for interpretation of depositional environments, fracture density and distribution as well as thin section, geochemical, and petrophysical analyses. Structural mapping and log analysis in the Dundee (Devonian) and Trenton/Black River (Ordovician) suggest a close spatial relationship among gross dolomite distribution and regional-scale, wrench fault related NW-SE and NE-SW structural trends. A high temperature origin for much of the dolomite in the 3 studied intervals (based upon initial fluid inclusion homogenization temperatures and stable isotopic analyses,) coupled with persistent association of this dolomite in reservoirs coincident with wrench fault-related features, is strong evidence for these reservoirs being influenced by hydrothermal dolomitization. For the Niagaran (Silurian), a comprehensive high resolution sequence stratigraphic framework has been developed for a pinnacle reef in the northern reef trend where we had 100% core coverage throughout the reef section. Major findings to date are that facies types, when analyzed at a detailed level, have direct links to reservoir porosity and permeability in these dolomites. This pattern is consistent with our original hypothesis of primary facies control on dolomitization and resulting reservoir quality at some level. The identification of distinct and predictable vertical stacking patterns within a hierarchical sequence and cycle framework provides a high degree of confidence at this point

  10. Circuit quantum electrodynamics

    NASA Astrophysics Data System (ADS)

    Bishop, Lev Samuel

    Circuit Quantum Electrodynamics (cQED), the study of the interaction between superconducting circuits behaving as artificial atoms and 1-dimensional transmission-line resonators, has shown much promise for quantum information processing tasks. For the purposes of quantum computing it is usual to approximate the artificial atoms as 2-level qubits, and much effort has been expended on attempts to isolate these qubits from the environment and to invent ever more sophisticated control and measurement schemes. Rather than focussing on these technological aspects of the field, this thesis investigates the opportunities for using these carefully engineered systems for answering questions of fundamental physics. The low dissipation and small mode volume of the circuits allows easy access to the strong-coupling regime of quantum optics, where one can investigate the interaction of light and matter at the level of single atoms and photons. A signature of strong coupling is the splitting of the cavity transmission peak into a pair of resolvable peaks when a single resonant atom is placed inside the cavity---an effect known as vacuum Rabi splitting. The cQED architecture is ideally suited for going beyond this linear response effect. This thesis shows that increasing the drive power results in two unique nonlinear features in the transmitted heterodyne signal: the supersplitting of each vacuum Rabi peak into a doublet, and the appearance of additional peaks with the characteristic n spacing of the Jaynes-Cummings ladder. These constitute direct evidence for the coupling between the quantized microwave field and the anharmonic spectrum of a superconducting qubit acting as an artificial atom. This thesis also addresses the idea of Bell tests, which are experiments that aim to disprove certain types of classical theories, presenting a proposed method for preparing maximally entangled 3-qubit states via a 'preparation by measurement' scheme using an optimized filter on the time

  11. Optically controllable molecular logic circuits

    SciTech Connect

    Nishimura, Takahiro Fujii, Ryo; Ogura, Yusuke; Tanida, Jun

    2015-07-06

    Molecular logic circuits represent a promising technology for observation and manipulation of biological systems at the molecular level. However, the implementation of molecular logic circuits for temporal and programmable operation remains challenging. In this paper, we demonstrate an optically controllable logic circuit that uses fluorescence resonance energy transfer (FRET) for signaling. The FRET-based signaling process is modulated by both molecular and optical inputs. Based on the distance dependence of FRET, the FRET pathways required to execute molecular logic operations are formed on a DNA nanostructure as a circuit based on its molecular inputs. In addition, the FRET pathways on the DNA nanostructure are controlled optically, using photoswitching fluorescent molecules to instruct the execution of the desired operation and the related timings. The behavior of the circuit can thus be controlled using external optical signals. As an example, a molecular logic circuit capable of executing two different logic operations was studied. The circuit contains functional DNAs and a DNA scaffold to construct two FRET routes for executing Input 1 AND Input 2 and Input 1 AND NOT Input 3 operations on molecular inputs. The circuit produced the correct outputs with all possible combinations of the inputs by following the light signals. Moreover, the operation execution timings were controlled based on light irradiation and the circuit responded to time-dependent inputs. The experimental results demonstrate that the circuit changes the output for the required operations following the input of temporal light signals.

  12. Integrated circuit cell library

    NASA Technical Reports Server (NTRS)

    Whitaker, Sterling R. (Inventor); Miles, Lowell H. (Inventor)

    2005-01-01

    According to the invention, an ASIC cell library for use in creation of custom integrated circuits is disclosed. The ASIC cell library includes some first cells and some second cells. Each of the second cells includes two or more kernel cells. The ASIC cell library is at least 5% comprised of second cells. In various embodiments, the ASIC cell library could be 10% or more, 20% or more, 30% or more, 40% or more, 50% or more, 60% or more, 70% or more, 80% or more, 90% or more, or 95% or more comprised of second cells.

  13. Base drive circuit

    DOEpatents

    Lange, Arnold C.

    1995-01-01

    An improved base drive circuit (10) having a level shifter (24) for providing bistable input signals to a pair of non-linear delays (30, 32). The non-linear delays (30, 32) provide gate control to a corresponding pair of field effect transistors (100, 106) through a corresponding pair of buffer components (88, 94). The non-linear delays (30, 32) provide delayed turn-on for each of the field effect transistors (100, 106) while an associated pair of transistors (72, 80) shunt the non-linear delays (30, 32) during turn-off of the associated field effect transistor (100, 106).

  14. Temperature-Controlling Circuit

    NASA Technical Reports Server (NTRS)

    Temple, Gerald

    1987-01-01

    Simple circuit switches current to electrical heater on and off to maintain temperature of room at 25 plus or minus 0.5 degree C. Lightweight, compact, reliable, insensitive to electrical noise, and uses single 5-Vdc power supply. Handles ac loads of 10 A. Designed to operate outside temperature controlled environment over range of -55 to +85 degree C. Thermistor provides input signal for simple temperature controller. Output of controller applied to solid-state relay, which in turn switches current to resistance heater.

  15. Small Depth Quantum Circuits

    DTIC Science & Technology

    2007-01-01

    circuit families and quantum Turing machines”. Theoretical Computer Science, 1-2(276):147–181, 2002. [20] S. Parker and M . B . Plenio . “Efficient...unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 polynomial-size...xn, b 〉 = |x1, ..., xn, b ⊕ f(x1, . . . , xn)〉 This is just an easy form of simulating any classical function in a reversible manner. If f(x1

  16. Itch Mechanisms and Circuits

    PubMed Central

    Han, Liang; Dong, Xinzhong

    2014-01-01

    The itch-scratch reflex serves as a protective mechanism in everyday life. However, chronic persistent itching can be devastating. Despite the clinical importance of the itch sensation, its mechanism remains elusive. In the past decade, substantial progress has been made to uncover the mystery of itching. Here, we review the molecules, cells, and circuits known to mediate the itch sensation, which, coupled with advances in understanding the pathophysiology of chronic itching conditions, will hopefully contribute to the development of new anti-itch therapies. PMID:24819620

  17. Seeing Circuits Assemble

    PubMed Central

    Lichtman, Jeff W.; Smith, Stephen J.

    2009-01-01

    Developmental neurobiology has been greatly invigorated by a recent string of breakthroughs in molecular biology and optical physics that permit direct in vivo observation of neural circuit assembly. The imaging done thus far suggests that as brains are built, a significant amount of unbuilding is also occurring. We offer the view that this tumult is the result of the intersecting behaviors of the many single-celled creatures (i.e., neurons, glia, and progenitors) that inhabit brains. New tools will certainly be needed if we wish to monitor the myriad cooperative and competitive interactions at play in the cellular society that builds brains. PMID:18995818

  18. Photonic Integrated Circuits

    NASA Technical Reports Server (NTRS)

    Merritt, Scott; Krainak, Michael

    2016-01-01

    Integrated photonics generally is the integration of multiple lithographically defined photonic and electronic components and devices (e.g. lasers, detectors, waveguides passive structures, modulators, electronic control and optical interconnects) on a single platform with nanometer-scale feature sizes. The development of photonic integrated circuits permits size, weight, power and cost reductions for spacecraft microprocessors, optical communication, processor buses, advanced data processing, and integrated optic science instrument optical systems, subsystems and components. This is particularly critical for small spacecraft platforms. We will give an overview of some NASA applications for integrated photonics.

  19. Dynamic pulse difference circuit

    DOEpatents

    Erickson, Gerald L.

    1978-01-01

    A digital electronic circuit of especial use for subtracting background activity pulses in gamma spectrometry comprises an up-down counter connected to count up with signal-channel pulses and to count down with background-channel pulses. A detector responsive to the count position of the up-down counter provides a signal when the up-down counter has completed one scaling sequence cycle of counts in the up direction. In an alternate embodiment, a detector responsive to the count position of the up-down counter provides a signal upon overflow of the counter.

  20. Signal Processing Circuit Development.

    DTIC Science & Technology

    1986-07-01

    Simplified active filter circuit 64 42. Video output amplifier 66 43. 64/128 gated clock circuitry 68 44. Two pole Sallen-Key active filters 7!1 45. Switched...four quadrant multiplier, log compression, multiple pole active video filtering and black level control. In what follows in this report an attempt...chip is shown in Fiqu-e 5. This is the master synch chip which generates all of the control signals necessary for TV monitor presentation of video data

  1. Base drive circuit

    DOEpatents

    Lange, A.C.

    1995-04-04

    An improved base drive circuit having a level shifter for providing bistable input signals to a pair of non-linear delays. The non-linear delays provide gate control to a corresponding pair of field effect transistors through a corresponding pair of buffer components. The non-linear delays provide delayed turn-on for each of the field effect transistors while an associated pair of transistors shunt the non-linear delays during turn-off of the associated field effect transistor. 2 figures.

  2. Sequential circuit design for radiation hardened multiple voltage integrated circuits

    SciTech Connect

    Clark, Lawrence T.; McIver, III, John K.

    2009-11-24

    The present invention includes a radiation hardened sequential circuit, such as a bistable circuit, flip-flop or other suitable design that presents substantial immunity to ionizing radiation while simultaneously maintaining a low operating voltage. In one embodiment, the circuit includes a plurality of logic elements that operate on relatively low voltage, and a master and slave latches each having storage elements that operate on a relatively high voltage.

  3. St Gallen molecular subtypes in primary breast cancer and matched lymph node metastases - aspects on distribution and prognosis for patients with luminal A tumours: results from a prospective randomised trial

    PubMed Central

    2013-01-01

    Background The St Gallen surrogate molecular subtype definitions classify the oestrogen (ER) positive breast cancer into the luminal A and luminal B subtypes according to proliferation rate and/or expression of human epidermal growth factor receptor 2 (HER2) with differences in prognosis and chemo-responsiveness. Primary tumours and lymph node metastases might represent different malignant clones, but in the clinical setting only the biomarker profile of the primary tumour is used for selection of adjuvant systemic treatment. The present study aimed to classify primary breast tumours and matched lymph node metastases into luminal A, luminal B, HER2-positive and triple-negative subtypes and compare the distributions. Methods Eighty-five patients with available tumour tissue from both locations were classified. The distribution of molecular subtypes in primary tumours and corresponding lymph node metastases were compared, and related to 5-year distant disease-free survival (DDFS). Results The St Gallen molecular subtypes were discordant between primary tumours and matched lymph node metastases in 11% of the patients (p = 0.06). The luminal A subtype in the primary tumour shifted to a subtype with a worse prognostic profile in the lymph node metastases in 7 of 45 cases (16%) whereas no shift in the opposite direction was observed (0/38) (p = 0.02). All subtypes had an increased hazard for developing distant metastasis during the first 5 years after diagnosis in both primary breast tumours and matched lymph node metastases, compared with the luminal A subtype. Conclusion The classification according to the St Gallen molecular subtypes in primary tumours and matched lymph node metastases, implicates a shift to a more aggressive subtype in synchronous lymph node metastases compared to the primary breast tumour. The selection of systemic adjuvant therapy might benefit from taking the molecular subtypes in the metastatic node into account. PMID:24274821

  4. Jitter compensation circuit

    DOEpatents

    Sullivan, J.S.; Ball, D.G.

    1997-09-09

    The instantaneous V{sub co} signal on a charging capacitor is sampled and the charge voltage on capacitor C{sub o} is captured just prior to its discharge into the first stage of magnetic modulator. The captured signal is applied to an averaging circuit with a long time constant and to the positive input terminal of a differential amplifier. The averaged V{sub co} signal is split between a gain stage (G = 0.975) and a feedback stage that determines the slope of the voltage ramp applied to the high speed comparator. The 97.5% portion of the averaged V{sub co} signal is applied to the negative input of a differential amplifier gain stage (G = 10). The differential amplifier produces an error signal by subtracting 97.5% of the averaged V{sub co} signal from the instantaneous value of sampled V{sub co} signal and multiplying the difference by ten. The resulting error signal is applied to the positive input of a high speed comparator. The error signal is then compared to a voltage ramp that is proportional to the averaged V{sub co} values squared divided by the total volt-second product of the magnetic compression circuit. 11 figs.

  5. Jitter compensation circuit

    DOEpatents

    Sullivan, James S.; Ball, Don G.

    1997-01-01

    The instantaneous V.sub.co signal on a charging capacitor is sampled and the charge voltage on capacitor C.sub.o is captured just prior to its discharge into the first stage of magnetic modulator. The captured signal is applied to an averaging circuit with a long time constant and to the positive input terminal of a differential amplifier. The averaged V.sub. co signal is split between a gain stage (G=0.975) and a feedback stage that determines the slope of the voltage ramp applied to the high speed comparator. The 97.5% portion of the averaged V.sub.co signal is applied to the negative input of a differential amplifier gain stage (G=10). The differential amplifier produces an error signal by subtracting 97.5% of the averaged V.sub.co signal from the instantaneous value of sampled V.sub.co signal and multiplying the difference by ten. The resulting error signal is applied to the positive input of a high speed comparator. The error signal is then compared to a voltage ramp that is proportional to the averaged V.sub.co values squared divided by the total volt-second product of the magnetic compression circuit.

  6. Simple Cell Balance Circuit

    NASA Technical Reports Server (NTRS)

    Johnson, Steven D.; Byers, Jerry W.; Martin, James A.

    2012-01-01

    A method has been developed for continuous cell voltage balancing for rechargeable batteries (e.g. lithium ion batteries). A resistor divider chain is provided that generates a set of voltages representing the ideal cell voltage (the voltage of each cell should be as if the cells were perfectly balanced). An operational amplifier circuit with an added current buffer stage generates the ideal voltage with a very high degree of accuracy, using the concept of negative feedback. The ideal voltages are each connected to the corresponding cell through a current- limiting resistance. Over time, having the cell connected to the ideal voltage provides a balancing current that moves the cell voltage very close to that ideal level. In effect, it adjusts the current of each cell during charging, discharging, and standby periods to force the cell voltages to be equal to the ideal voltages generated by the resistor divider. The device also includes solid-state switches that disconnect the circuit from the battery so that it will not discharge the battery during storage. This solution requires relatively few parts and is, therefore, of lower cost and of increased reliability due to the fewer failure modes. Additionally, this design uses very little power. A preliminary model predicts a power usage of 0.18 W for an 8-cell battery. This approach is applicable to a wide range of battery capacities and voltages.

  7. Quasi-Linear Circuit

    NASA Technical Reports Server (NTRS)

    Bradley, William; Bird, Ross; Eldred, Dennis; Zook, Jon; Knowles, Gareth

    2013-01-01

    This work involved developing spacequalifiable switch mode DC/DC power supplies that improve performance with fewer components, and result in elimination of digital components and reduction in magnetics. This design is for missions where systems may be operating under extreme conditions, especially at elevated temperature levels from 200 to 300 degC. Prior art for radiation-tolerant DC/DC converters has been accomplished utilizing classical magnetic-based switch mode converter topologies; however, this requires specific shielding and component de-rating to meet the high-reliability specifications. It requires complex measurement and feedback components, and will not enable automatic re-optimization for larger changes in voltage supply or electrical loading condition. The innovation is a switch mode DC/DC power supply that eliminates the need for processors and most magnetics. It can provide a well-regulated voltage supply with a gain of 1:100 step-up to 8:1 step down, tolerating an up to 30% fluctuation of the voltage supply parameters. The circuit incorporates a ceramic core transformer in a manner that enables it to provide a well-regulated voltage output without use of any processor components or magnetic transformers. The circuit adjusts its internal parameters to re-optimize its performance for changes in supply voltage, environmental conditions, or electrical loading at the output

  8. Automated Design of Quantum Circuits

    NASA Technical Reports Server (NTRS)

    Williams, Colin P.; Gray, Alexander G.

    2000-01-01

    In order to design a quantum circuit that performs a desired quantum computation, it is necessary to find a decomposition of the unitary matrix that represents that computation in terms of a sequence of quantum gate operations. To date, such designs have either been found by hand or by exhaustive enumeration of all possible circuit topologies. In this paper we propose an automated approach to quantum circuit design using search heuristics based on principles abstracted from evolutionary genetics, i.e. using a genetic programming algorithm adapted specially for this problem. We demonstrate the method on the task of discovering quantum circuit designs for quantum teleportation. We show that to find a given known circuit design (one which was hand-crafted by a human), the method considers roughly an order of magnitude fewer designs than naive enumeration. In addition, the method finds novel circuit designs superior to those previously known.

  9. A bit serial sequential circuit

    NASA Technical Reports Server (NTRS)

    Hu, S.; Whitaker, S.

    1990-01-01

    Normally a sequential circuit with n state variables consists of n unique hardware realizations, one for each state variable. All variables are processed in parallel. This paper introduces a new sequential circuit architecture that allows the state variables to be realized in a serial manner using only one next state logic circuit. The action of processing the state variables in a serial manner has never been addressed before. This paper presents a general design procedure for circuit construction and initialization. Utilizing pass transistors to form the combinational next state forming logic in synchronous sequential machines, a bit serial state machine can be realized with a single NMOS pass transistor network connected to shift registers. The bit serial state machine occupies less area than other realizations which perform parallel operations. Moreover, the logical circuit of the bit serial state machine can be modified by simply changing the circuit input matrix to develop an adaptive state machine.

  10. Electronic control circuits: A compilation

    NASA Technical Reports Server (NTRS)

    1973-01-01

    A compilation of technical R and D information on circuits and modular subassemblies is presented as a part of a technology utilization program. Fundamental design principles and applications are given. Electronic control circuits discussed include: anti-noise circuit; ground protection device for bioinstrumentation; temperature compensation for operational amplifiers; hybrid gatling capacitor; automatic signal range control; integrated clock-switching control; and precision voltage tolerance detector.

  11. Power-Supply-Conditioning Circuit

    NASA Technical Reports Server (NTRS)

    Primas, L. E.; Loveland, R. C.

    1989-01-01

    Fluctuations of voltage suppressed in power supplies for precise radio-frequency circuits. Circuit suppresses both periodic and random deviations of dc supply voltage from desired steady level. Highly-stable feedback voltage regulator, conditioner intended in conjunction with conventional power-supply circuit to provide constant voltage to atomic frequency standard or other precise oscillator. Without conditioners, outputs of most commercial power supplies contain fluctuations causing unacceptably-large phase and amplitude modulation of precise oscillators.

  12. Pharmacokinetics and RC Circuit Concepts

    NASA Astrophysics Data System (ADS)

    Cock, Mieke De; Janssen, Paul

    2013-11-01

    Most introductory physics courses include a chapter on RC circuits in which the differential equations for the charging and discharging of a capacitor are derived. A number of papers in this journal describe lab experiments dealing with the measurement of different parameters in such RC circuits. In this contribution, we report on a lab experiment we developed for students majoring in pharmacy, using RC circuits to simulate a pharmacokinetic process.

  13. Source-circuit design overview

    NASA Technical Reports Server (NTRS)

    Ross, R. G., Jr.

    1983-01-01

    The source circuit is the fundamental electrical building block of a large central-station array; it consists of a series-parallel network of solar cells that develops full system voltage. The array field is generally made up of a large number of parallel source circuits. Source-circuit electrical configuration is driven by a number of design considerations, which must be considered simultaneously. Array fault tolerance and hot spot heating endurance are examined in detail.

  14. STOCK AND DISTRIBUTION OF TOTAL AND CORN-DERIVED SOIL ORGANIC CARBON IN AGGREGATE AND PRIMARY PARTICLE FRACTIONS FOR DIFFERENT LAND USE AND SOIL MANAGEMENT PRACTICES

    SciTech Connect

    Puget, P; Lal, Rattan; Izaurralde, R Cesar C.; Post, M; Owens, Lloyd

    2005-04-01

    Land use, soil management, and cropping systems affect stock, distribution, and residence time of soil organic carbon (SOC). Therefore, SOC stock and its depth distribution and association with primary and secondary particles were assessed in long-term experiments at the North Appalachian Experimental Watersheds near Coshocton, Ohio, through *13C techniques. These measurements were made for five land use and soil management treatments: (1) secondary forest, (2) meadow converted from no-till (NT) corn since 1988, (3) continuous NT corn since 1970, (4) continuous NT corn-soybean in rotation with ryegrass since 1984, and (5) conventional plow till (PT) corn since 1984. Soil samples to 70-cm depth were obtained in 2002 in all treatments. Significant differences in soil properties were observed among land use treatments for 0 to 5-cm depth. The SOC concentration (g C kg*1 of soil) in the 0 to 5-cm layer was 44.0 in forest, 24.0 in meadow, 26.1 in NT corn, 19.5 in NT corn-soybean, and 11.1 i n PT corn. The fraction of total C in corn residue converted to SOC was 11.9% for NT corn, 10.6% for NT corn-soybean, and 8.3% for PT corn. The proportion of SOC derived from corn residue was 96% for NT corn in the 0 to 5-cm layer, and it decreased gradually with depth and was 50% in PT corn. The mean SOC sequestration rate on conversion from PT to NT was 280 kg C ha*1 y*1. The SOC concentration decreased with reduction in aggregate size, and macro-aggregates contained 15 to 35% more SOC concentration than microaggregates. In comparison with forest, the magnitude of SOC depletion in the 0 to 30-cm layer was 15.5 Mg C/ha (24.0%) in meadow, 12.7 Mg C/ha (19.8%) in NT corn, 17.3 Mg C/ha (26.8%) in NT corn-soybean, and 23.3 Mg C/ha (35.1%) in PT corn. The SOC had a long turnover time when located deeper in the subsoil.

  15. Spatial and size-frequency distributions of boulders on the floor of crater Boguslawsky, the primary target of the Luna-Glob mission.

    NASA Astrophysics Data System (ADS)

    Ivanov, Mikhail; Head, James; Hiesinger, Harald; Bazilevskiy, Alexander; Hendrik Pasckert, Jan; Bauch, Karin

    Crater Boguslawsky (73S, 44E) is the primary target for the lander-oriented Russian mission Luna-Glob. The rocky surfaces represent serious threats to landers. We have conducted a survey of the NAC images seeking for the rocky sites on the floor and assessing quantitative parameters of the size-frequency distributions (SFD) of boulders. Two craters on the Boguslawsky floor show abundant boulders in their surroundings. In the vicinity of Crater 1 (73.0S, 42.0E, 405 m), we have counted 9,000 rock fragments (1-13 m) at a radial distance <670 m outside the crater rim. The mean density of boulders in this zone is 76 rocks/10,000 m2. Boulders are arranged in elongated ray-like clusters. Shallow grooves (tracks) are associated with some larger boulders; the visible depth of the tracks is 0.3-0.5 m. There are 3,200 boulders (1-8 m) around Crater 4 (72.6S 44.9E, 340 m) at a radial distance <500 m outside the crater rim; the mean density is 52 rocks/10,000 m2. The spatial distribution of boulders around Crater 4 is similar to that at Crater 1, but no tracks are associated with boulders at Crater 4. The mean density of boulders around Crater 4 is 30% less than that at Crater 1, which suggests that Crater 4 is 30-50 Ma older than Crater 1 [Basilevsky et al., 2013]. The lack of boulder tracks in the vicinity of Crater 4 implies that a layer of regolith 0.3-0.5 m thick has been reworked during this time interval. A slope of -4.37 characterizes the SFD of boulders around Crater 1, whereas the SFD of boulders around Crater 4 has a slope of -5.54. These differences in slope indicate the preferential destruction of the larger rock fragments and suggest that up to 90% of boulders in the diameter range 8-12 m are fragmented into smaller pieces during the 30-50 Ma time span.

  16. Magnetic compression laser driving circuit

    DOEpatents

    Ball, Don G.; Birx, Dan; Cook, Edward G.

    1993-01-01

    A magnetic compression laser driving circuit is disclosed. The magnetic compression laser driving circuit compresses voltage pulses in the range of 1.5 microseconds at 20 Kilovolts of amplitude to pulses in the range of 40 nanoseconds and 60 Kilovolts of amplitude. The magnetic compression laser driving circuit includes a multi-stage magnetic switch where the last stage includes a switch having at least two turns which has larger saturated inductance with less core material so that the efficiency of the circuit and hence the laser is increased.

  17. Magnetic compression laser driving circuit

    DOEpatents

    Ball, D.G.; Birx, D.; Cook, E.G.

    1993-01-05

    A magnetic compression laser driving circuit is disclosed. The magnetic compression laser driving circuit compresses voltage pulses in the range of 1.5 microseconds at 20 kilovolts of amplitude to pulses in the range of 40 nanoseconds and 60 kilovolts of amplitude. The magnetic compression laser driving circuit includes a multi-stage magnetic switch where the last stage includes a switch having at least two turns which has larger saturated inductance with less core material so that the efficiency of the circuit and hence the laser is increased.

  18. Four-junction superconducting circuit

    NASA Astrophysics Data System (ADS)

    Qiu, Yueyin; Xiong, Wei; He, Xiao-Ling; Li, Tie-Fu; You, J. Q.

    2016-06-01

    We develop a theory for the quantum circuit consisting of a superconducting loop interrupted by four Josephson junctions and pierced by a magnetic flux (either static or time-dependent). In addition to the similarity with the typical three-junction flux qubit in the double-well regime, we demonstrate the difference of the four-junction circuit from its three-junction analogue, including its advantages over the latter. Moreover, the four-junction circuit in the single-well regime is also investigated. Our theory provides a tool to explore the physical properties of this four-junction superconducting circuit.

  19. PRECISION TIME-DELAY CIRCUIT

    DOEpatents

    Creveling, R.

    1959-03-17

    A tine-delay circuit which produces a delay time in d. The circuit a capacitor, an te back resistance, connected serially with the anode of the diode going to ground. At the start of the time delay a negative stepfunction is applied to the series circuit and initiates a half-cycle transient oscillatory voltage terminated by a transient oscillatory voltage of substantially higher frequency. The output of the delay circuit is taken at the junction of the inductor and diode where a sudden voltage rise appears after the initiation of the higher frequency transient oscillations.

  20. Multifunctional pattern-generating circuits.

    PubMed

    Briggman, K L; Kristan, W B

    2008-01-01

    The ability of distinct anatomical circuits to generate multiple behavioral patterns is widespread among vertebrate and invertebrate species. These multifunctional neuronal circuits are the result of multistable neural dynamics and modular organization. The evidence suggests multifunctional circuits can be classified by distinct architectures, yet the activity patterns of individual neurons involved in more than one behavior can vary dramatically. Several mechanisms, including sensory input, the parallel activity of projection neurons, neuromodulation, and biomechanics, are responsible for the switching between patterns. Recent advances in both analytical and experimental tools have aided the study of these complex circuits.

  1. A Circuit to Demonstrate Phase Relationships in "RLC" Circuits

    ERIC Educational Resources Information Center

    Sokol, P. E.; Warren, G.; Zheng, B.; Smith, P.

    2013-01-01

    We have developed a circuit to demonstrate the phase relationships between resistive and reactive elements in series "RLC" circuits. We utilize a differential amplifier to allow the phases of the three elements and the current to be simultaneously displayed on an inexpensive four channel oscilloscope. We have included a novel circuit…

  2. Circuit Theory for Full Counting Statistics in Multiterminal Circuits

    NASA Astrophysics Data System (ADS)

    Nazarov, Yu. V.; Bagrets, D. A.

    2002-05-01

    We propose a theory that treats the current, noise, and, generally, the full current statistics of electron transfer in a mesoscopic system in a unified, simple, and efficient way. The theory appears to be a circuit theory of 2×2 matrices associated with Keldysh Green functions. We illustrate the theory by considering the big fluctuations of currents in various three-terminal circuits.

  3. Development of beam lead RF integrated circuits

    NASA Technical Reports Server (NTRS)

    Kline, A. J.; Kermode, A. W.

    1975-01-01

    This paper describes the design and development of a set of multifunction VHF/UHF integrated circuits aimed at providing a major improvement in spacecraft radio reliability through low stress operation and the processing of these circuits in beam-lead form. The methods evolved for the high frequency characterization of the devices are discussed together with the design of suitable test fixtures. Typical test results and the distribution of test parameters are presented. A unique carrier for beam-lead devices is described, and the need for such a device is discussed. The application of the carrier to device screening, burn-in and drift measurements is discussed together with the incentives for providing these capabilities. An overview of the integration of the devices into the spacecraft radio is given and candidate assembly processes are discussed. The technology impact of this approach upon future spacecraft radio systems is qualitatively examined.

  4. ELECTRONIC INTEGRATING CIRCUIT

    DOEpatents

    Englemann, R.H.

    1963-08-20

    An electronic integrating circuit using a transistor with a capacitor connected between the emitter and collector through which the capacitor discharges at a rate proportional to the input current at the base is described. Means are provided for biasing the base with an operating bias and for applying a voltage pulse to the capacitor for charging to an initial voltage. A current dividing diode is connected between the base and emitter of the transistor, and signal input terminal means are coupled to the juncture of the capacitor and emitter and to the base of the transistor. At the end of the integration period, the residual voltage on said capacitor is less by an amount proportional to the integral of the input signal. Either continuous or intermittent periods of integration are provided. (AEC)

  5. ELECTRONIC PULSE SCALING CIRCUITS

    DOEpatents

    Cooke-Yarborough, E.H.

    1958-11-18

    Electronic pulse scaling circults of the klnd comprlsing a serles of bi- stable elements connected ln sequence, usually in the form of a rlng so as to be cycllcally repetitive at the highest scallng factor, are described. The scaling circuit comprises a ring system of bi-stable elements each arranged on turn-off to cause, a succeeding element of the ring to be turned-on, and one being arranged on turn-off to cause a further element of the ring to be turned-on. In addition, separate means are provided for applying a turn-off pulse to all the elements simultaneously, and for resetting the elements to a starting condition at the end of each cycle.

  6. Modeling cortical circuits.

    SciTech Connect

    Rohrer, Brandon Robinson; Rothganger, Fredrick H.; Verzi, Stephen J.; Xavier, Patrick Gordon

    2010-09-01

    The neocortex is perhaps the highest region of the human brain, where audio and visual perception takes place along with many important cognitive functions. An important research goal is to describe the mechanisms implemented by the neocortex. There is an apparent regularity in the structure of the neocortex [Brodmann 1909, Mountcastle 1957] which may help simplify this task. The work reported here addresses the problem of how to describe the putative repeated units ('cortical circuits') in a manner that is easily understood and manipulated, with the long-term goal of developing a mathematical and algorithmic description of their function. The approach is to reduce each algorithm to an enhanced perceptron-like structure and describe its computation using difference equations. We organize this algorithmic processing into larger structures based on physiological observations, and implement key modeling concepts in software which runs on parallel computing hardware.

  7. CIRCUS--A digital computer program for transient analysis of electronic circuits

    NASA Technical Reports Server (NTRS)

    Moore, W. T.; Steinbert, L. L.

    1968-01-01

    Computer program simulates the time domain response of an electronic circuit to an arbitrary forcing function. CIRCUS uses a charge-control parameter model to represent each semiconductor device. Given the primary photocurrent, the transient behavior of a circuit in a radiation environment is determined.

  8. The negative differential resistance characteristics of an RC-IGBT and its equivalent circuit model

    NASA Astrophysics Data System (ADS)

    Wenliang, Zhang; Yangjun, Zhu; Shuojin, Lu; Xiaoli, Tian

    2014-02-01

    A simple equivalent circuit model is proposed according to the device structure of reverse conducting insulated gate bipolar transistors (RC-IGBT). Mathematical derivation and circuit simulations indicate that this model can explain the snap-back effect (including primary snap-back effect, secondary snap-back effect, and reverse snap-back effect) and hysteresis effect perfectly.

  9. Turkish Students' Conceptions about the Simple Electric Circuits

    ERIC Educational Resources Information Center

    Cepni, Salih; Keles, Esra

    2006-01-01

    In this study, the Turkish students' understanding level of electric circuits consisting of two bulbs and one battery was investigated by using open-ended questions. Two-hundred fifty students, whose ages range from 11 to 22, were chosen from five different groups at primary, secondary and university levels in Trabzon in Turkey. In analyzing…

  10. Digital circuits using universal logic gates

    NASA Technical Reports Server (NTRS)

    Whitaker, Sterling R. (Inventor); Miles, Lowell H. (Inventor); Cameron, Eric G. (Inventor); Donohoe, Gregory W. (Inventor); Gambles, Jody W. (Inventor)

    2004-01-01

    According to the invention, a digital circuit design embodied in at least one of a structural netlist, a behavioral netlist, a hardware description language netlist, a full-custom ASIC, a semi-custom ASIC, an IP core, an integrated circuit, a hybrid of chips, one or more masks, a FPGA, and a circuit card assembly is disclosed. The digital circuit design includes first and second sub-circuits. The first sub-circuits comprise a first percentage of the digital circuit design and the second sub-circuits comprise a second percentage of the digital circuit design. Each of the second sub-circuits is substantially comprised of one or more kernel circuits. The kernel circuits are comprised of selection circuits. The second percentage is at least 5%. In various embodiments, the second percentage could be at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 95%.

  11. Ion implanted dielectric elastomer circuits

    NASA Astrophysics Data System (ADS)

    O'Brien, Benjamin M.; Rosset, Samuel; Anderson, Iain A.; Shea, Herbert R.

    2013-06-01

    Starfish and octopuses control their infinite degree-of-freedom arms with panache—capabilities typical of nature where the distribution of reflex-like intelligence throughout soft muscular networks greatly outperforms anything hard, heavy, and man-made. Dielectric elastomer actuators show great promise for soft artificial muscle networks. One way to make them smart is with piezo-resistive Dielectric Elastomer Switches (DES) that can be combined with artificial muscles to create arbitrary digital logic circuits. Unfortunately there are currently no reliable materials or fabrication process. Thus devices typically fail within a few thousand cycles. As a first step in the search for better materials we present a preliminary exploration of piezo-resistors made with filtered cathodic vacuum arc metal ion implantation. DES were formed on polydimethylsiloxane silicone membranes out of ion implanted gold nano-clusters. We propose that there are four distinct regimes (high dose, above percolation, on percolation, low dose) in which gold ion implanted piezo-resistors can operate and present experimental results on implanted piezo-resistors switching high voltages as well as a simple artificial muscle inverter. While gold ion implanted DES are limited by high hysteresis and low sensitivity, they already show promise for a range of applications including hysteretic oscillators and soft generators. With improvements to implanter process control the promise of artificial muscle circuitry for soft smart actuator networks could become a reality.

  12. Pharmacokinetics and "RC" Circuit Concepts

    ERIC Educational Resources Information Center

    De Cock, Mieke; Janssen, Paul

    2013-01-01

    Most introductory physics courses include a chapter on "RC" circuits in which the differential equations for the charging and discharging of a capacitor are derived. A number of papers in this journal describe lab experiments dealing with the measurement of different parameters in such "RC" circuits. In this contribution, we…

  13. Cell short circuit, preshort signature

    NASA Technical Reports Server (NTRS)

    Lurie, C.

    1980-01-01

    Short-circuit events observed in ground test simulations of DSCS-3 battery in-orbit operations are analyzed. Voltage signatures appearing in the data preceding the short-circuit event are evaluated. The ground test simulation is briefly described along with performance during reconditioning discharges. Results suggest that a characteristic signature develops prior to a shorting event.

  14. Sequential Polarity-Reversing Circuit

    NASA Technical Reports Server (NTRS)

    Labaw, Clayton C.

    1994-01-01

    Proposed circuit reverses polarity of electric power supplied to bidirectional dc motor, reversible electro-mechanical actuator, or other device operating in direction depending on polarity. Circuit reverses polarity each time power turned on, without need for additional polarity-reversing or direction signals and circuitry to process them.

  15. Demonstrations with an "LCR" Circuit

    ERIC Educational Resources Information Center

    Kraftmakher, Yaakov

    2011-01-01

    The "LCR" circuit is an important topic in the course of electricity and magnetism. Papers in this field consider mainly the forced oscillations and resonance. Our aim is to show how to demonstrate the free and self-excited oscillations in an "LCR" circuit. (Contains 4 figures.)

  16. Time domain analog circuit simulation

    NASA Astrophysics Data System (ADS)

    Fijnvandraat, J. G.; Houben, S. H. M. J.; Ter Maten, E. J. W.; Peters, J. M. F.

    2006-01-01

    Recent developments of new methods for simulating electric circuits are described. Emphasis is put on methods that fit existing datastructures for backward differentiation formulae methods. These methods can be modified to apply to hierarchically organized datastructures, which allows for efficient simulation of large designs of circuits in the electronics industry.

  17. Trigger Circuit for Marx Generators

    DTIC Science & Technology

    2001-02-08

    A trigger circuit is provided for a trigger system for a Marx generator column. The column includes a plurality of metal electrode pairs wherein the...electrode (trigatron) spark gap switch forming the first spark gap of the Marx generator column. The triggering circuit includes a trigger

  18. Dive In to Aquatic Circuits.

    ERIC Educational Resources Information Center

    Goldfarb, Joseph M.

    1995-01-01

    The article presents a method for swimming teachers and coaches to stave off workout boredom in their students by using a circuit in the pool. After explaining how to set up a training circuit, the article describes sample stations and notes important safety precautions. (SM)

  19. An Electronics Course Emphasizing Circuit Design

    ERIC Educational Resources Information Center

    Bergeson, Haven E.

    1975-01-01

    Describes a one-quarter introductory electronics course in which the students use a variety of inexpensive integrated circuits to design and construct a large number of useful circuits. Presents the subject matter of the course in three parts: linear circuits, digital circuits, and more complex circuits. (GS)

  20. Solid state remote circuit selector switch

    NASA Technical Reports Server (NTRS)

    Peterson, V. S.

    1970-01-01

    Remote switching circuit utilizes voltage logic to switch on desired circuit. Circuit controls rotating multi-range pressure transducers in jet engine testing and can be used in coded remote circuit activator where sequence of switching has to occur in defined length of time to prevent false or undesired circuit activation.

  1. 49 CFR 236.728 - Circuit, trap.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Circuit, trap. 236.728 Section 236.728... Circuit, trap. A term applied to a circuit used where it is desirable to provide a track circuit but where it is impracticable to maintain a track circuit....

  2. Demultiplexer circuit for neural stimulation

    DOEpatents

    Wessendorf, Kurt O; Okandan, Murat; Pearson, Sean

    2012-10-09

    A demultiplexer circuit is disclosed which can be used with a conventional neural stimulator to extend the number of electrodes which can be activated. The demultiplexer circuit, which is formed on a semiconductor substrate containing a power supply that provides all the dc electrical power for operation of the circuit, includes digital latches that receive and store addressing information from the neural stimulator one bit at a time. This addressing information is used to program one or more 1:2.sup.N demultiplexers in the demultiplexer circuit which then route neural stimulation signals from the neural stimulator to an electrode array which is connected to the outputs of the 1:2.sup.N demultiplexer. The demultiplexer circuit allows the number of individual electrodes in the electrode array to be increased by a factor of 2.sup.N with N generally being in a range of 2-4.

  3. Genetic Dissection of Neural Circuits

    PubMed Central

    Luo, Liqun; Callaway, Edward M.; Svoboda, Karel

    2009-01-01

    Understanding the principles of information processing in neural circuits requires systematic characterization of the participating cell types and their connections, and the ability to measure and perturb their activity. Genetic approaches promise to bring experimental access to complex neural systems, including genetic stalwarts such as the fly and mouse, but also to nongenetic systems such as primates. Together with anatomical and physiological methods, cell-type-specific expression of protein markers and sensors and transducers will be critical to construct circuit diagrams and to measure the activity of genetically defined neurons. Inactivation and activation of genetically defined cell types will establish causal relationships between activity in specific groups of neurons, circuit function, and animal behavior. Genetic analysis thus promises to reveal the logic of the neural circuits in complex brains that guide behaviors. Here we review progress in the genetic analysis of neural circuits and discuss directions for future research and development. PMID:18341986

  4. Modeling and Verification of Distributed Generation and Voltage Regulation Equipment for Unbalanced Distribution Power Systems; Annual Subcontract Report, June 2007

    SciTech Connect

    Davis, M. W.; Broadwater, R.; Hambrick, J.

    2007-07-01

    This report summarizes the development of models for distributed generation and distribution circuit voltage regulation equipment for unbalanced power systems and their verification through actual field measurements.

  5. Photodiode circuits for retinal prostheses.

    PubMed

    Loudin, J D; Cogan, S F; Mathieson, K; Sher, A; Palanker, D V

    2011-10-01

    Photodiode circuits show promise for the development of high-resolution retinal prostheses. While several of these systems have been constructed and some even implanted in humans, existing descriptions of the complex optoelectronic interaction between light, photodiode, and the electrode/electrolyte load are limited. This study examines this interaction in depth with theoretical calculations and experimental measurements. Actively biased photoconductive and passive photovoltaic circuits are investigated, with the photovoltaic circuits consisting of one or more diodes connected in series, and the photoconductive circuits consisting of a single diode in series with a pulsed bias voltage. Circuit behavior and charge injection levels were markedly different for platinum and sputtered iridium-oxide film (SIROF) electrodes. Photovoltaic circuits were able to deliver 0.038 mC/cm(2) (0.75 nC/phase) per photodiode with 50- μm platinum electrodes, and 0.54-mC/cm(2) (11 nC/phase) per photodiode with 50-μ m SIROF electrodes driven with 0.5-ms pulses of light at 25 Hz. The same pulses applied to photoconductive circuits with the same electrodes were able to deliver charge injections as high as 0.38 and 7.6 mC/cm(2) (7.5 and 150 nC/phase), respectively. We demonstrate photovoltaic stimulation of rabbit retina in-vitro, with 0.5-ms pulses of 905-nm light using peak irradiance of 1 mW/mm(2). Based on the experimental data, we derive electrochemical and optical safety limits for pixel density and charge injection in various circuits. While photoconductive circuits offer smaller pixels, photovoltaic systems do not require an external bias voltage. Both classes of circuits show promise for the development of high-resolution optoelectronic retinal prostheses.

  6. Gate drive latching circuit for an auxiliary resonant commutation circuit

    NASA Technical Reports Server (NTRS)

    Delgado, Eladio Clemente (Inventor); Kheraluwala, Mustansir Hussainy (Inventor)

    1999-01-01

    A gate drive latching circuit for an auxiliary resonant commutation circuit for a power switching inverter includes a current monitor circuit providing a current signal to a pair of analog comparators to implement latching of one of a pair of auxiliary switching devices which are used to provide commutation current for commutating switching inverters in the circuit. Each of the pair of comparators feeds a latching circuit which responds to an active one of the comparators for latching the associated gate drive circuit for one of the pair of auxiliary commutating switches. An initial firing signal is applied to each of the commutating switches to gate each into conduction and the resulting current is monitored to determine current direction and therefore the one of the switches which is carrying current. The comparator provides a latching signal to the one of the auxiliary power switches which is actually conducting current and latches that particular power switch into an on state for the duration of current through the device. The latching circuit is so designed that the only time one of the auxiliary switching devices can be latched on is during the duration of an initial firing command signal.

  7. 30 CFR 75.800 - High-voltage circuits; circuit breakers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-voltage circuits; circuit breakers. 75.800... § 75.800 High-voltage circuits; circuit breakers. High-voltage circuits entering the underground area of any coal mine shall be protected by suitable circuit breakers of adequate interrupting...

  8. 49 CFR 236.731 - Controller, circuit.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Controller, circuit. A device for opening and closing electric circuits. ... 49 Transportation 4 2013-10-01 2013-10-01 false Controller, circuit. 236.731 Section 236.731 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD...

  9. 49 CFR 236.731 - Controller, circuit.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Controller, circuit. A device for opening and closing electric circuits. ... 49 Transportation 4 2012-10-01 2012-10-01 false Controller, circuit. 236.731 Section 236.731 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD...

  10. 49 CFR 236.731 - Controller, circuit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Controller, circuit. A device for opening and closing electric circuits. ... 49 Transportation 4 2014-10-01 2014-10-01 false Controller, circuit. 236.731 Section 236.731 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD...

  11. 49 CFR 236.731 - Controller, circuit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Controller, circuit. A device for opening and closing electric circuits. ... 49 Transportation 4 2011-10-01 2011-10-01 false Controller, circuit. 236.731 Section 236.731 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD...

  12. 49 CFR 236.731 - Controller, circuit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Controller, circuit. A device for opening and closing electric circuits. ... 49 Transportation 4 2010-10-01 2010-10-01 false Controller, circuit. 236.731 Section 236.731 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD...

  13. Nanofluidic Transistor Circuits

    NASA Astrophysics Data System (ADS)

    Chang, Hsueh-Chia; Cheng, Li-Jing; Yan, Yu; Slouka, Zdenek; Senapati, Satyajyoti

    2012-02-01

    Non-equilibrium ion/fluid transport physics across on-chip membranes/nanopores is used to construct rectifying, hysteretic, oscillatory, excitatory and inhibitory nanofluidic elements. Analogs to linear resistors, capacitors, inductors and constant-phase elements were reported earlier (Chang and Yossifon, BMF 2009). Nonlinear rectifier is designed by introducing intra-membrane conductivity gradient and by asymmetric external depletion with a reverse rectification (Yossifon and Chang, PRL, PRE, Europhys Lett 2009-2011). Gating phenomenon is introduced by functionalizing polyelectrolytes whose conformation is field/pH sensitive (Wang, Chang and Zhu, Macromolecules 2010). Surface ion depletion can drive Rubinstein's microvortex instability (Chang, Yossifon and Demekhin, Annual Rev of Fluid Mech, 2012) or Onsager-Wien's water dissociation phenomenon, leading to two distinct overlimiting I-V features. Bipolar membranes exhibit an S-hysteresis due to water dissociation (Cheng and Chang, BMF 2011). Coupling the hysteretic diode with some linear elements result in autonomous ion current oscillations, which undergo classical transitions to chaos. Our integrated nanofluidic circuits are used for molecular sensing, protein separation/concentration, electrospray etc.

  14. PHOTOSENSITIVE RELAY CONTROL CIRCUIT

    DOEpatents

    Martin, C.F.

    1958-01-14

    adapted for the measurement of the time required for an oscillating member to pass through a preselected number of oscillations, after being damped to a certain maximum amplitude of oscillation. A mirror is attached to the moving member and directs light successively to a photocell which is part of a trigger unit and to first and second photocells which are part of a starter unit, as the member swings to its maximum amplitude. The starter and trigger units comprise thyratrons and relays so interconnected that the trigger circuit, although generating a counter pulse, does not register a count in the counter when the light traverses both photocells of the starter unit. When the amplitude of oscillation of the member decreases to where the second photocell is not transversed, the triggei pulse is received by the counter. The counter taen operates to register the desired number of oscillations and initiates and terminates a timer for measuring the time irterval for the preselected number of oscillations.

  15. Variational integrators for electric circuits

    SciTech Connect

    Ober-Blöbaum, Sina; Tao, Molei; Cheng, Mulin; Owhadi, Houman; Marsden, Jerrold E.

    2013-06-01

    In this contribution, we develop a variational integrator for the simulation of (stochastic and multiscale) electric circuits. When considering the dynamics of an electric circuit, one is faced with three special situations: 1. The system involves external (control) forcing through external (controlled) voltage sources and resistors. 2. The system is constrained via the Kirchhoff current (KCL) and voltage laws (KVL). 3. The Lagrangian is degenerate. Based on a geometric setting, an appropriate variational formulation is presented to model the circuit from which the equations of motion are derived. A time-discrete variational formulation provides an iteration scheme for the simulation of the electric circuit. Dependent on the discretization, the intrinsic degeneracy of the system can be canceled for the discrete variational scheme. In this way, a variational integrator is constructed that gains several advantages compared to standard integration tools for circuits; in particular, a comparison to BDF methods (which are usually the method of choice for the simulation of electric circuits) shows that even for simple LCR circuits, a better energy behavior and frequency spectrum preservation can be observed using the developed variational integrator.

  16. Global optimization of digital circuits

    NASA Astrophysics Data System (ADS)

    Flandera, Richard

    1991-12-01

    This thesis was divided into two tasks. The first task involved developing a parser which could translate a behavioral specification in Very High-Speed Integrated Circuits (VHSIC) Hardware Description Language (VHDL) into the format used by an existing digital circuit optimization tool, Boolean Reasoning In Scheme (BORIS). Since this tool is written in Scheme, a dialect of Lisp, the parser was also written in Scheme. The parser was implemented is Artez's modification of Earley's Algorithm. Additionally, a VHDL tokenizer was implemented in Scheme and a portion of the VHDL grammar was converted into the format which the parser uses. The second task was the incorporation of intermediate functions into BORIS. The existing BORIS contains a recursive optimization system that optimizes digital circuits by using circuit outputs as inputs into other circuits. Intermediate functions provide a greater selection of functions to be used as circuits inputs. Using both intermediate functions and output functions, the costs of the circuits in the test set were reduced by 43 percent. This is a 10 percent reduction when compared to the existing recursive optimization system. Incorporating intermediate functions into BORIS required the development of an intermediate-function generator and a set of control methods to keep the computation time from increasing exponentially.

  17. Integrated circuits, and design and manufacture thereof

    DOEpatents

    Auracher, Stefan; Pribbernow, Claus; Hils, Andreas

    2006-04-18

    A representation of a macro for an integrated circuit layout. The representation may define sub-circuit cells of a module. The module may have a predefined functionality. The sub-circuit cells may include at least one reusable circuit cell. The reusable circuit cell may be configured such that when the predefined functionality of the module is not used, the reusable circuit cell is available for re-use.

  18. Framed 4-graphs: Euler tours, Gauss circuits and rotating circuits

    SciTech Connect

    Il'yutko, Denis P

    2011-09-30

    We consider connected finite 4-valent graphs with the structure of opposite edges at each vertex (framed 4-graphs). For any of such graphs there exist Euler tours, in travelling along which at each vertex we turn from an edge to a nonopposite one (rotating circuits); and at the same time, it is not true that for any such graph there exists an Euler tour passing from an edge to the opposite one at each vertex (a Gauss circuit). The main result of the work is an explicit formula connecting the adjacency matrices of the Gauss circuit and an arbitrary Euler tour. This formula immediately gives us a criterion for the existence of a Gauss circuit on a given framed 4-graph. It turns out that the results are also valid for all symmetric matrices (not just for matrices realisable by a chord diagram). Bibliography: 24 titles.

  19. Amenorrhea - primary

    MedlinePlus

    ... of periods - primary Images Primary amenorrhea Normal uterine anatomy (cut section) Absence of menstruation (amenorrhea) References Bulun SE. The physiology and pathology of the female reproductive axis. In: ...

  20. Overpulse railgun energy recovery circuit

    DOEpatents

    Honig, E.M.

    1984-09-28

    The invention presented relates to a high-power pulsing circuit and more particularly to a repetitive pulse inductive energy storage and transfer circuit for an electromagnetic launcher. In an electromagnetic launcher such as a railgun for propelling a projectile at high velocity, an overpulse energy recovery circuit is employed to transfer stored inductive energy from a source inductor to the railgun inductance to propel the projectile down the railgun. Switching circuitry and an energy transfer capacitor are used to switch the energy back to the source inductor in readiness for a repetitive projectile propelling cycle.

  1. Counterpulse railgun energy recovery circuit

    DOEpatents

    Honig, E.M.

    1984-09-28

    The invention presented relates to a high-power pulsing circuit and more particularly to a repetitive pulse inductive energy storage and transfer circuit for an electromagnetic launcher. In an electromagnetic launcher such as a railgun for propelling a projectile at high velocity, a counterpulse energy recovery circuit is employed to transfer stored inductive energy from a source inductor to the railgun inductance to propel the projectile down the railgun. Switching circuitry and an energy transfer capacitor are used to switch the energy back to the source inductor in readiness for a repetitive projectile propelling cycle.

  2. Analog circuits for relaxation networks.

    PubMed

    Card, H

    1993-12-01

    Selected examples are presented of recent advances, primarily from the U.S. and Canada, in analog circuits for relaxation networks. Relaxation networks having feedback connections exhibit potentially greater computational power per neuron than feedforward networks. They are also more poorly understood especially with respect to learning algorithms. Examples are described of analog circuits for (i) supervised learning in deterministic Boltzmann machines, (ii) unsupervised competitive learning and feature maps and (iii) networks with resistive grids for vision and audition tasks. We also discuss recent progress on in-circuit learning and synaptic weight storage mechanisms.

  3. Altered Nociceptive Neuronal Circuits After Neonatal Peripheral Inflammation

    NASA Astrophysics Data System (ADS)

    Ruda, M. A.; Ling, Qing-Dong; Hohmann, Andrea G.; Peng, Yuan Bo; Tachibana, Toshiya

    2000-07-01

    Nociceptive neuronal circuits are formed during embryonic and postnatal times when painful stimuli are normally absent or limited. Today, medical procedures for neonates with health risks can involve tissue injury and pain for which the long-term effects are unknown. To investigate the impact of neonatal tissue injury and pain on development of nociceptive neuronal circuitry, we used an animal model of persistent hind paw peripheral inflammation. We found that, as adults, these animals exhibited spinal neuronal circuits with increased input and segmental changes in nociceptive primary afferent axons and altered responses to sensory stimulation.

  4. Exploration of Digital Circuits and Transistor-Level Testing in the DARPA TRUST Program

    DTIC Science & Technology

    2015-03-01

    EXPLORATION OF DIGITAL CIRCUITS AND TRANSISTOR-LEVEL TESTING IN THE DARPA TRUST PROGRAM THESIS Ralph K. Tatum, Second Lieutenant, USAF AFIT-ENG-MS-15...Government and is not subject to copyright protection in the United States. AFIT-ENG-MS-15-M-040 EXPLORATION OF DIGITAL CIRCUITS AND TRANSISTOR-LEVEL...RELEASE; DISTRIBUTION UNLIMITED AFIT-ENG-MS-15-M-040 EXPLORATION OF DIGITAL CIRCUITS AND TRANSISTOR-LEVEL TESTING IN THE DARPA TRUST PROGRAM THESIS

  5. Student Conceptions of Simple Circuits.

    ERIC Educational Resources Information Center

    Fredette, Norman; Lochhead, John

    1980-01-01

    Investigates some conceptual difficulties which college students have with regard to simple direct current circuits. The clinical interview technique was used with 57 students in a freshman level engineering course. (HM)

  6. Midbrain circuits for defensive behaviour.

    PubMed

    Tovote, Philip; Esposito, Maria Soledad; Botta, Paolo; Chaudun, Fabrice; Fadok, Jonathan P; Markovic, Milica; Wolff, Steffen B E; Ramakrishnan, Charu; Fenno, Lief; Deisseroth, Karl; Herry, Cyril; Arber, Silvia; Lüthi, Andreas

    2016-06-09

    Survival in threatening situations depends on the selection and rapid execution of an appropriate active or passive defensive response, yet the underlying brain circuitry is not understood. Here we use circuit-based optogenetic, in vivo and in vitro electrophysiological, and neuroanatomical tracing methods to define midbrain periaqueductal grey circuits for specific defensive behaviours. We identify an inhibitory pathway from the central nucleus of the amygdala to the ventrolateral periaqueductal grey that produces freezing by disinhibition of ventrolateral periaqueductal grey excitatory outputs to pre-motor targets in the magnocellular nucleus of the medulla. In addition, we provide evidence for anatomical and functional interaction of this freezing pathway with long-range and local circuits mediating flight. Our data define the neuronal circuitry underlying the execution of freezing, an evolutionarily conserved defensive behaviour, which is expressed by many species including fish, rodents and primates. In humans, dysregulation of this 'survival circuit' has been implicated in anxiety-related disorders.

  7. Accelerated hybrid-circuit production

    NASA Technical Reports Server (NTRS)

    Berg, J. E.; Dassele, M. A.

    1979-01-01

    Modified die-bonding machine speeds up hybrid-circuit production. Utilizing two pedestals, one for die tray and another for substrate tray, increased production and decreased error-margin are possible.

  8. Focal plane infrared readout circuit

    NASA Technical Reports Server (NTRS)

    Pain, Bedabrata (Inventor)

    2002-01-01

    An infrared imager, such as a spectrometer, includes multiple infrared photodetectors and readout circuits for reading out signals from the photodetectors. Each readout circuit includes a buffered direct injection input circuit including a differential amplifier with active feedback provided through an injection transistor. The differential amplifier includes a pair of input transistors, a pair of cascode transistors and a current mirror load. Photocurrent from a photodetector can be injected onto an integration capacitor in the readout circuit with high injection efficiency at high speed. A high speed, low noise, wide dynamic range linear infrared multiplexer array for reading out infrared detectors with large capacitances can be achieved even when short exposure times are used. The effect of image lag can be reduced.

  9. Chaos Control for Chua's Circuits

    NASA Astrophysics Data System (ADS)

    Tôrres, L. A. B.; Aguirre, L. A.; Palhares, R. M.; Mendes, E. M. A. M.

    The practical implementation of Chua's circuit control methods is discussed in this chapter. In order to better address this subject, an inductorless Chua's circuit realization is first presented, followed by practical issues related to data analysis, mathematical modelling, and dynamical characterization associated to this electronic chaotic oscillator. As a consequence of the investigation of different control strategies applied to Chua's circuit, a tradeoff among control objective, control energy, and model complexity is devised, which quite naturally leads to a principle that seems to be of general nature: the Information Transmission Via Control (ITVC) for nonlinear oscillators. The main purpose of the present chapter is to serve as an introductory guide to the universe of Chua's circuit control, synchronization, and mathematical modelling.

  10. Reverse engineering of integrated circuits

    DOEpatents

    Chisholm, Gregory H.; Eckmann, Steven T.; Lain, Christopher M.; Veroff, Robert L.

    2003-01-01

    Software and a method therein to analyze circuits. The software comprises several tools, each of which perform particular functions in the Reverse Engineering process. The analyst, through a standard interface, directs each tool to the portion of the task to which it is most well suited, rendering previously intractable problems solvable. The tools are generally used iteratively to produce a successively more abstract picture of a circuit, about which incomplete a priori knowledge exists.

  11. Equivalent circuit for birdcage resonators.

    PubMed

    Harpen, M D

    1993-02-01

    We present an equivalent circuit analysis for both low pass and high pass birdcage resonators loaded with lossy samples. In a generalization of the method of Hoult and Lauterbur (J. Magn. Reson. 34, 425 (1979)), we also derive circuit component values by application of the laws of electrodynamics. Measured resonance spectra, quality factors, and feed point impedances in a test resonator are shown to be in agreement with those predicted by the proposed model.

  12. Optogenetic modulation of neural circuits that underlie reward seeking

    PubMed Central

    Stuber, Garret D.; Britt, Jonathan P.; Bonci, Antonello

    2012-01-01

    The manifestation of complex neuropsychiatric disorders such as drug and alcohol addiction is thought to result from progressive maladaptive alterations in neural circuit function. Clearly, repeated drug exposure alters a distributed network of neural circuit elements. However, a more precise understanding of addiction has been hampered by an inability to control and, consequently, identify specific circuit components that underlie addictive behaviors. The development of optogenetic strategies for selectively modulating the activity of genetically defined neuronal populations has provided a means for determining the relationship between circuit function and behavior with a level of precision that has been previously unobtainable. Here, we briefly review the main optogenetic studies that have contributed to elucidate neural circuit connectivity within the ventral tegmental area and the nucleus accumbens, two brain nuclei that are essential for the manifestation of addiction-related behaviors. Additional targeted manipulation of genetically defined neural populations in these brain regions as well as afferent and efferent structures promises to delineate the cellular mechanisms and circuit components required for the transition from natural goal-directed behavior to compulsive reward-seeking despite negative consequences. PMID:22196983

  13. A cortical circuit for gain control by behavioral state.

    PubMed

    Fu, Yu; Tucciarone, Jason M; Espinosa, J Sebastian; Sheng, Nengyin; Darcy, Daniel P; Nicoll, Roger A; Huang, Z Josh; Stryker, Michael P

    2014-03-13

    The brain's response to sensory input is strikingly modulated by behavioral state. Notably, the visual response of mouse primary visual cortex (V1) is enhanced by locomotion, a tractable and accessible example of a time-locked change in cortical state. The neural circuits that transmit behavioral state to sensory cortex to produce this modulation are unknown. In vivo calcium imaging of behaving animals revealed that locomotion activates vasoactive intestinal peptide (VIP)-positive neurons in mouse V1 independent of visual stimulation and largely through nicotinic inputs from basal forebrain. Optogenetic activation of VIP neurons increased V1 visual responses in stationary awake mice, artificially mimicking the effect of locomotion, and photolytic damage of VIP neurons abolished the enhancement of V1 responses by locomotion. These findings establish a cortical circuit for the enhancement of visual response by locomotion and provide a potential common circuit for the modulation of sensory processing by behavioral state.

  14. 30 CFR 75.809 - Identification of circuit breakers and disconnecting switches.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... disconnecting switches. 75.809 Section 75.809 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... High-Voltage Distribution § 75.809 Identification of circuit breakers and disconnecting switches. Circuit breakers and disconnecting switches underground shall be marked for identification....

  15. 30 CFR 75.809 - Identification of circuit breakers and disconnecting switches.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... disconnecting switches. 75.809 Section 75.809 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... High-Voltage Distribution § 75.809 Identification of circuit breakers and disconnecting switches. Circuit breakers and disconnecting switches underground shall be marked for identification....

  16. 30 CFR 75.809 - Identification of circuit breakers and disconnecting switches.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... disconnecting switches. 75.809 Section 75.809 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... High-Voltage Distribution § 75.809 Identification of circuit breakers and disconnecting switches. Circuit breakers and disconnecting switches underground shall be marked for identification....

  17. 30 CFR 75.809 - Identification of circuit breakers and disconnecting switches.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... disconnecting switches. 75.809 Section 75.809 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... High-Voltage Distribution § 75.809 Identification of circuit breakers and disconnecting switches. Circuit breakers and disconnecting switches underground shall be marked for identification....

  18. 30 CFR 75.809 - Identification of circuit breakers and disconnecting switches.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... disconnecting switches. 75.809 Section 75.809 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... High-Voltage Distribution § 75.809 Identification of circuit breakers and disconnecting switches. Circuit breakers and disconnecting switches underground shall be marked for identification....

  19. 30 CFR 75.802 - Protection of high-voltage circuits extending underground.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection of high-voltage circuits extending... LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Underground High-Voltage Distribution § 75.802 Protection of high-voltage circuits extending underground. (a) Except...

  20. Study on the new structure and its influencing factors of miniature circuit breaker for short circuit protection

    NASA Astrophysics Data System (ADS)

    He, Gong; Ming, Zong

    2017-01-01

    Miniature Circuit Breaker (MCB) is widely used in terminal power distributions and civil buildings, its annual production has more than 500 million poles. However, in terms of the short circuit protection of MCB, and there's no short circuit delay function, so it can not reach the full selective protection, even through the cooperation between the time selection and the current selection. In paper, a new structure of MCB's electromagnetic tripping device is proposed, which is able to realize short-circuit delay protection. The new is on the traditional structure added a secondary winding, then controlling the on or off of the secondary winding, using its demagnetization effect to realize the short time delay function when the secondary winding is closed. This is a new idea in the field of low-voltage circuit breakers. In addition, take the U type electromagnet as an example, through the analysis of the magnetic circuit, the main factors that affect the magnetic effect of the secondary winding are studied by using MATLAB.

  1. Difference-Equation/Flow-Graph Circuit Analysis

    NASA Technical Reports Server (NTRS)

    Mcvey, I. M.

    1988-01-01

    Numerical technique enables rapid, approximate analyses of electronic circuits containing linear and nonlinear elements. Practiced in variety of computer languages on large and small computers; for circuits simple enough, programmable hand calculators used. Although some combinations of circuit elements make numerical solutions diverge, enables quick identification of divergence and correction of circuit models to make solutions converge.

  2. Improved self arbitrated VLSI asynchronous circuits

    NASA Technical Reports Server (NTRS)

    Winterrowd, P.

    1991-01-01

    This paper introduces an improved method for designing the class of CMOS VLSI asynchronous sequential circuits introduced in the paper by Sterling R. Whitaker and Gary K. Maki, 'Self Arbitrated VLSI Asynchronous Circuits.' Of main interest here is the simple design by inspection rules that arise from these circuits. This paper presents a variation on these circuits which reduces the number of transistors required.

  3. 30 CFR 56.6403 - Branch circuits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Branch circuits. 56.6403 Section 56.6403... Blasting § 56.6403 Branch circuits. (a) If electric blasting includes the use of branch circuits, each branch shall be equipped with a safety switch or equivalent method to isolate the circuits to be used....

  4. Multi-Layer E-Textile Circuits

    NASA Technical Reports Server (NTRS)

    Dunne, Lucy E.; Bibeau, Kaila; Mulligan, Lucie; Frith, Ashton; Simon, Cory

    2012-01-01

    Stitched e-textile circuits facilitate wearable, flexible, comfortable wearable technology. However, while stitched methods of e-textile circuits are common, multi-layer circuit creation remains a challenge. Here, we present methods of stitched multi-layer circuit creation using accessible tools and techniques.

  5. Laminar circuit organization and response modulation in mouse visual cortex

    PubMed Central

    Olivas, Nicholas D.; Quintanar-Zilinskas, Victor; Nenadic, Zoran; Xu, Xiangmin

    2012-01-01

    The mouse has become an increasingly important animal model for visual system studies, but few studies have investigated local functional circuit organization of mouse visual cortex. Here we used our newly developed mapping technique combining laser scanning photostimulation (LSPS) with fast voltage-sensitive dye (VSD) imaging to examine the spatial organization and temporal dynamics of laminar circuit responses in living slice preparations of mouse primary visual cortex (V1). During experiments, LSPS using caged glutamate provided spatially restricted neuronal activation in a specific cortical layer, and evoked responses from the stimulated layer to its functionally connected regions were detected by VSD imaging. In this study, we first provided a detailed analysis of spatiotemporal activation patterns at specific V1 laminar locations and measured local circuit connectivity. Then we examined the role of cortical inhibition in the propagation of evoked cortical responses by comparing circuit activity patterns in control and in the presence of GABAa receptor antagonists. We found that GABAergic inhibition was critical in restricting layer-specific excitatory activity spread and maintaining topographical projections. In addition, we investigated how AMPA and NMDA receptors influenced cortical responses and found that blocking AMPA receptors abolished interlaminar functional projections, and the NMDA receptor activity was important in controlling visual cortical circuit excitability and modulating activity propagation. The NMDA receptor antagonist reduced neuronal population activity in time-dependent and laminar-specific manners. Finally, we used the quantitative information derived from the mapping experiments and presented computational modeling analysis of V1 circuit organization. Taken together, the present study has provided important new information about mouse V1 circuit organization and response modulation. PMID:23060751

  6. 46 CFR 28.365 - Overcurrent protection and switched circuits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... a steering circuit, each circuit must be protected against both overload and short circuit. Each overcurrent device in a steering system power and control circuit must provide short circuit protection...

  7. 46 CFR 28.365 - Overcurrent protection and switched circuits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... a steering circuit, each circuit must be protected against both overload and short circuit. Each overcurrent device in a steering system power and control circuit must provide short circuit protection...

  8. 46 CFR 28.365 - Overcurrent protection and switched circuits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... a steering circuit, each circuit must be protected against both overload and short circuit. Each overcurrent device in a steering system power and control circuit must provide short circuit protection...

  9. 46 CFR 28.365 - Overcurrent protection and switched circuits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... a steering circuit, each circuit must be protected against both overload and short circuit. Each overcurrent device in a steering system power and control circuit must provide short circuit protection...

  10. 46 CFR 28.365 - Overcurrent protection and switched circuits.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... a steering circuit, each circuit must be protected against both overload and short circuit. Each overcurrent device in a steering system power and control circuit must provide short circuit protection...

  11. Conceptual studies for a mercury target circuit

    SciTech Connect

    Sigg, B.

    1996-06-01

    For the now favored target design of the European Spallation Source project, i.e. the version using mercury as target material, a basic concept of the primary system has been worked out. It does not include a detailed design of the various components of the target circuit, but tries to outline a feasible solution for the system. Besides the removal of the thermal power of about 3MW produced in the target by the proton beam, the primary system has to satisfy a number of other requirements related to processing, safety, and operation. The basic proposal uses an electromagnetic pump and a mercury-water intermediate heat excanger, but other alternatives are also being discussed. Basic safety requirements, i.e. protection against radiation and toxic mercury vapours, are satisfied by a design using an air-tight primary system containment, double-walled tubes in the intermediate heat exchanger, a fail-safe system for decay heat removal, and a remote handling facility for the active part of the system. Much engineering work has still to be done, because many details of the design of the mercury and gas processing systems remain to be clarified, the thermal-hydraulic components need further optimisation, the system for control and instrumentation is only known in outline and a through safety analysis will be required.

  12. 49 CFR 236.5 - Design of control circuits on closed circuit principle.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Design of control circuits on closed circuit..., AND APPLIANCES Rules and Instructions: All Systems General § 236.5 Design of control circuits on closed circuit principle. All control circuits the functioning of which affects safety of train...

  13. 30 CFR 75.518 - Electric equipment and circuits; overload and short circuit protection.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Electric equipment and circuits; overload and... Equipment-General § 75.518 Electric equipment and circuits; overload and short circuit protection. Automatic... electric equipment and circuits against short circuit and overloads. Three-phase motors on all...

  14. 30 CFR 75.518 - Electric equipment and circuits; overload and short circuit protection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Electric equipment and circuits; overload and... Equipment-General § 75.518 Electric equipment and circuits; overload and short circuit protection. Automatic... electric equipment and circuits against short circuit and overloads. Three-phase motors on all...

  15. 30 CFR 75.518 - Electric equipment and circuits; overload and short circuit protection.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Electric equipment and circuits; overload and... Equipment-General § 75.518 Electric equipment and circuits; overload and short circuit protection. Automatic... electric equipment and circuits against short circuit and overloads. Three-phase motors on all...

  16. 30 CFR 75.518 - Electric equipment and circuits; overload and short circuit protection.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Electric equipment and circuits; overload and... Equipment-General § 75.518 Electric equipment and circuits; overload and short circuit protection. Automatic... electric equipment and circuits against short circuit and overloads. Three-phase motors on all...

  17. 30 CFR 75.518 - Electric equipment and circuits; overload and short circuit protection.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Electric equipment and circuits; overload and... Equipment-General § 75.518 Electric equipment and circuits; overload and short circuit protection. Automatic... electric equipment and circuits against short circuit and overloads. Three-phase motors on all...

  18. Introduction to lethal circuit transformations

    NASA Astrophysics Data System (ADS)

    Fišer, Petr; Schmidt, Jan

    2015-12-01

    Logic optimization is a process that takes a logic circuit description (Boolean network) as an input and tries to refine it, to reduce its size and/or depth. An ideal optimization process should be able to devise an optimum implementation of a network in a reasonable time, given any circuit structure at the input. However, there are cases where it completely fails to produce even near-optimum solutions. Such cases are typically induced by non-standard circuit structure modifications. Surprisingly enough, such deviated structures are frequently present in standard benchmark sets too. We may only wonder whether it is an intention of the benchmarks creators, or just an unlucky coincidence. Even though synthesis tools should be primarily well suited for practical circuits, there is no guarantee that, e.g., a higher-level synthesis process will not generate such unlucky structures. Here we present examples of circuit transformations that lead to failure of most of state-of-the-art logic synthesis and optimization processes, both academic and commercial, and suggest actions to mitigate the disturbing effects.

  19. Dynamical compensation in physiological circuits.

    PubMed

    Karin, Omer; Swisa, Avital; Glaser, Benjamin; Dor, Yuval; Alon, Uri

    2016-11-08

    Biological systems can maintain constant steady-state output despite variation in biochemical parameters, a property known as exact adaptation. Exact adaptation is achieved using integral feedback, an engineering strategy that ensures that the output of a system robustly tracks its desired value. However, it is unclear how physiological circuits also keep their output dynamics precise-including the amplitude and response time to a changing input. Such robustness is crucial for endocrine and neuronal homeostatic circuits because they need to provide a precise dynamic response in the face of wide variation in the physiological parameters of their target tissues; how such circuits compensate their dynamics for unavoidable natural fluctuations in parameters is unknown. Here, we present a design principle that provides the desired robustness, which we call dynamical compensation (DC). We present a class of circuits that show DC by means of a nonlinear feedback loop in which the regulated variable controls the functional mass of the controlling endocrine or neuronal tissue. This mechanism applies to the control of blood glucose by insulin and explains several experimental observations on insulin resistance. We provide evidence that this mechanism may also explain compensation and organ size control in other physiological circuits.

  20. Logic circuits from zero forcing.

    PubMed

    Burgarth, Daniel; Giovannetti, Vittorio; Hogben, Leslie; Severini, Simone; Young, Michael

    We design logic circuits based on the notion of zero forcing on graphs; each gate of the circuits is a gadget in which zero forcing is performed. We show that such circuits can evaluate every monotone Boolean function. By using two vertices to encode each logical bit, we obtain universal computation. We also highlight a phenomenon of "back forcing" as a property of each function. Such a phenomenon occurs in a circuit when the input of gates which have been already used at a given time step is further modified by a computation actually performed at a later stage. Finally, we show that zero forcing can be also used to implement reversible computation. The model introduced here provides a potentially new tool in the analysis of Boolean functions, with particular attention to monotonicity. Moreover, in the light of applications of zero forcing in quantum mechanics, the link with Boolean functions may suggest a new directions in quantum control theory and in the study of engineered quantum spin systems. It is an open technical problem to verify whether there is a link between zero forcing and computation with contact circuits.

  1. Digital first order hold circuit

    NASA Technical Reports Server (NTRS)

    Chan, Fred N. (Inventor); Wensley, Gerald J. (Inventor)

    1989-01-01

    There is provided a digitally controlled first order hold circuit and waveform synthesizer for digitally controlling the representation of a function over an approximation interval. In accordance with the operation of the invention, the first order hold circuit and waveform generator receives a digital data input signal which contains initial condition data, up/down data, and slope data for the approximation interval. The initial condition data is loaded into an up/down counter which is incremented using counting data at a rate depending on the value of the slope data and in a direction depending on the value of the up-down data. In order to minimize delays arising from data acquistion, two frequency synthesizer circuits are provided such that one frequency synthesizer provides counting data while the other frequency synthesizer receives slope data. During alternating intervals, the other frequency synthesizer circuit provides counting data while the other circuit receives slope data. In addition, long length data input signals covering a plurality of approximation intervals are provided to reduce the demands on a main system central processing unit.

  2. Extratemporal lobe circuits in temporal lobe epilepsy.

    PubMed

    Bertram, Edward H

    2014-09-01

    There is increasing interest in the functional anatomy of epilepsy with the goal to identify the critical nodes in the seizure circuits so that therapy can be directed at them. This goal is especially important because direct delivery of therapy, either through electrical stimulation, drug infusion, or molecular therapies such as optogenetics, has become increasingly possible. In this article, we will review the basic functional anatomy of mesial temporal lobe epilepsy and its primary subcortical connection, the medial dorsal nucleus of the thalamus. Based on its anatomical connections and known physiological interactions, we propose a key role for this thalamic nucleus that is essential for the development of seizures, and this role suggests that this region is a potential therapeutic target.

  3. Motivational neural circuits underlying reinforcement learning.

    PubMed

    Averbeck, Bruno B; Costa, Vincent D

    2017-03-29

    Reinforcement learning (RL) is the behavioral process of learning the values of actions and objects. Most models of RL assume that the dopaminergic prediction error signal drives plasticity in frontal-striatal circuits. The striatum then encodes value representations that drive decision processes. However, the amygdala has also been shown to play an important role in forming Pavlovian stimulus-outcome associations. These Pavlovian associations can drive motivated behavior via the amygdala projections to the ventral striatum or the ventral tegmental area. The amygdala may, therefore, play a central role in RL. Here we compare the contributions of the amygdala and the striatum to RL and show that both the amygdala and striatum learn and represent expected values in RL tasks. Furthermore, value representations in the striatum may be inherited, to some extent, from the amygdala. The striatum may, therefore, play less of a primary role in learning stimulus-outcome associations in RL than previously suggested.

  4. Primary Hyperparathyroidism

    MedlinePlus

    ... What is PRIMARY HYPERPARATH YROIDIS M? The body’s parathyroid glands—four pea-sized glands in the neck—produce parathyroid hormone (PTH). Primary hyperparathyroidism (PHPT) is a condition ...

  5. Primary thrombocythemia

    MedlinePlus

    ... as myeloproliferative disorders. Others include: Chronic myelogenous leukemia Polycythemia vera Primary myelofibrosis This disorder is most common ... PA: Elsevier Saunders; 2013:chap 68. Tefferi A. Polycythemia vera, essential thrombocytoemia, and primary myelofibrosis. In: Goldman ...

  6. Primary Aldosteronism

    MedlinePlus

    ... Endocrinology Find an Endocrinologist Value of an Endocrinologist Learn About Clinical Trials Keep Your Body in Balance › Primary Aldosteronism Fact Sheet Primary Aldosteronism March 2012 Download PDFs English Espanol Editors Paul Stewart, MD, FRCP William Young, ...

  7. Fabrication, electrical characterization, and detection application of graphene-sheet-based electrical circuits.

    PubMed

    Peng, Yitian; Lei, Jianping

    2014-01-01

    The distribution of potential, electric field, and gradient of square of electric field was simulated via a finite element method for dielectrophoresis (DEP) assembly. Then reduced graphene oxide sheets (RGOS)- and graphene oxide sheets (GOS)-based electrical circuits were fabricated via DEP assembly. The mechanically exfoliated graphene sheets (MEGS)-based electrical circuit was also fabricated for comparison. The electrical transport properties of three types of graphene-based electrical circuits were measured. The MEGS-based electrical circuit possesses the best electrical conductivity, and the GOS-based electrical circuit has the poorest electrical conductivity among all three circuits. The three types of electrical circuits were applied for the detection of copper ions (Cu(2+)). The RGOS-based electrical circuit can detect the Cu(2+) when the concentration of Cu(2+) was as low as 10 nM in solution. The GOS-based electrical circuit can only detect Cu(2+) after chemical reduction. The possible mechanism of electron transfer was proposed for the detection. The facile fabrication method and excellent performance imply the RGOS-based electrical circuit has great potential to be applied to metal ion sensors.

  8. Monte Carlo study of secondary electrons and X-rays produced by different angular distributions of primary precipitating electrons interacting with the atmosphere

    NASA Astrophysics Data System (ADS)

    Sheldon, W. R.; Andersen, V.; Pinsky, L. S.

    Electron precipitation from the outer belt is an important input of energy and electric charge to the atmosphere. Its effect on the electrodynamics of the atmosphere depends on the resulting ionization profile (ionization rate vs. altitude). It is likely that the ionization profile is strongly affected by the angular distribution of precipitating electrons absorbed by the atmosphere. Definitive measurements of precipitating electrons at the top of the atmosphere have not been made; the usual assumption for calculations of this problem is that they have an isotropic distribution over the zenithal hemisphere. However, consideration of the mechanism leading to the precipitation of outer belt electrons suggests a different distribution: a trapped electron in the process of mirroring encounters a region near the top of the atmosphere where its gyro-circumference is equal to its mean-free-path and thus collides with an atmospheric molecule. In this case, precipitating electrons are traveling horizontally when they are absorbed in the atmosphere. In order to investigate differences in the ionization profile that may depend on the angular distribution of precipitating electrons, we have conducted a Monte Carlo study of this problem using the FLUKA code. The two angular distributions described previously were assumed with an energy spectrum typical for outer belt electrons up to 10 MeV; both electrons and X-rays were followed down to energies of 100 keV. The Monte Carlo results are compared to measurements of electrons in the atmosphere below 80 km made from rocket-boosted, parachute-deployed payloads, and to measurements of X-rays made on balloon payloads at altitudes of about 35 km. Also, the flux and energy spectrum of backscattered electrons traveling upward from the atmosphere are determined for the two angular distributions of precipitating electrons, isotropic over the zenithal hemisphere and horizontal absorption.

  9. Changes in the frequency distribution of energy deposited in short pathlengths as a function of energy degradation of the primary beam.

    NASA Technical Reports Server (NTRS)

    Baily, N. A.; Steigerwalt, J. E.; Hilbert, J. W.

    1972-01-01

    The frequency distributions of event size in the deposition of energy over small pathlengths have been measured after penetration of 44.3 MeV protons through various thicknesses of tissue-equivalent material. Results show that particle energy straggling of an initially monoenergetic proton beam after passage through an absorber causes the frequency distributions of energy deposited in short pathlengths of low atomic number materials to remain broad. In all cases investigated, the ratio of the most probable to the average energy losses has been significantly less than unity.

  10. Nuclear sensor signal processing circuit

    DOEpatents

    Kallenbach, Gene A.; Noda, Frank T.; Mitchell, Dean J.; Etzkin, Joshua L.

    2007-02-20

    An apparatus and method are disclosed for a compact and temperature-insensitive nuclear sensor that can be calibrated with a non-hazardous radioactive sample. The nuclear sensor includes a gamma ray sensor that generates tail pulses from radioactive samples. An analog conditioning circuit conditions the tail-pulse signals from the gamma ray sensor, and a tail-pulse simulator circuit generates a plurality of simulated tail-pulse signals. A computer system processes the tail pulses from the gamma ray sensor and the simulated tail pulses from the tail-pulse simulator circuit. The nuclear sensor is calibrated under the control of the computer. The offset is adjusted using the simulated tail pulses. Since the offset is set to zero or near zero, the sensor gain can be adjusted with a non-hazardous radioactive source such as, for example, naturally occurring radiation and potassium chloride.

  11. Chua's Circuit: Control and Synchronization

    NASA Astrophysics Data System (ADS)

    Irimiciuc, Stefan-Andrei; Vasilovici, Ovidiu; Dimitriu, Dan-Gheorghe

    Chaos-based data encryption is one of the most reliable methods used in secure communications. This implies a good control of a chaotic system and a good synchronization between the involved systems. Here, experimental results are shown on the control and synchronization of Chua's circuits. The control of the chaotic circuit was achieved by using the switching method. The influence of the control signal characteristics (amplitude, frequency and shape) on the system's states was also investigated. The synchronization of two similar chaotic circuits was studied, emphasizing the importance of the chaotic state characteristics of the Master system in respect to those of Slave system. It was shown that the synchronization does not depend on the chaotic state type, neither on the dimension (x, y or z) used for synchronization.

  12. Vertically Integrated Circuits at Fermilab

    SciTech Connect

    Deptuch, Grzegorz; Demarteau, Marcel; Hoff, James; Lipton, Ronald; Shenai, Alpana; Trimpl, Marcel; Yarema, Raymond; Zimmerman, Tom; /Fermilab

    2010-01-01

    The exploration of vertically integrated circuits, also commonly known as 3D-IC technology, for applications in radiation detection started at Fermilab in 2006. This paper examines the opportunities that vertical integration offers by looking at various 3D designs that have been completed by Fermilab. The emphasis is on opportunities that are presented by through silicon vias (TSV), wafer and circuit thinning, and finally fusion bonding techniques to replace conventional bump bonding. Early work by Fermilab has led to an international consortium for the development of 3D-IC circuits for High Energy Physics. For the first time, Fermilab has organized a 3D MPW run, to which more than 25 different designs have been submitted by the consortium.

  13. Vertically Integrated Circuits at Fermilab

    SciTech Connect

    Deptuch, Grzegorz; Demarteau, Marcel; Hoff, James; Lipton, Ronald; Shenai, Alpana; Trimpl, Marcel; Yarema, Raymond; Zimmerman, Tom; /Fermilab

    2009-01-01

    The exploration of the vertically integrated circuits, also commonly known as 3D-IC technology, for applications in radiation detection started at Fermilab in 2006. This paper examines the opportunities that vertical integration offers by looking at various 3D designs that have been completed by Fermilab. The emphasis is on opportunities that are presented by through silicon vias (TSV), wafer and circuit thinning and finally fusion bonding techniques to replace conventional bump bonding. Early work by Fermilab has led to an international consortium for the development of 3D-IC circuits for High Energy Physics. The consortium has submitted over 25 different designs for the Fermilab organized MPW run organized for the first time.

  14. Additive manufacturing of hybrid circuits

    SciTech Connect

    Bell, Nelson S.; Sarobol, Pylin; Cook, Adam; Clem, Paul G.; Keicher, David M.; Hirschfeld, Deidre; Hall, Aaron Christopher

    2016-03-26

    There is a rising interest in developing functional electronics using additively manufactured components. Considerations in materials selection and pathways to forming hybrid circuits and devices must demonstrate useful electronic function; must enable integration; and must complement the complex shape, low cost, high volume, and high functionality of structural but generally electronically passive additively manufactured components. This article reviews several emerging technologies being used in industry and research/development to provide integration advantages of fabricating multilayer hybrid circuits or devices. First, we review a maskless, noncontact, direct write (DW) technology that excels in the deposition of metallic colloid inks for electrical interconnects. Second, we review a complementary technology, aerosol deposition (AD), which excels in the deposition of metallic and ceramic powder as consolidated, thick conformal coatings and is additionally patternable through masking. As a result, we show examples of hybrid circuits/devices integrated beyond 2-D planes, using combinations of DW or AD processes and conventional, established processes.

  15. Improved methods of forming monolithic integrated circuits having complementary bipolar transistors

    NASA Technical Reports Server (NTRS)

    Bohannon, R. O., Jr.; Cashion, W. F.; Stehlin, R. A.

    1971-01-01

    Two new processes form complementary transistors in monolithic semiconductor circuits, require fewer steps /infusions/ than previous methods, and eliminate such problems as nonuniform h sub FE distribution, low yield, and large device formation.

  16. CHEETAH: circuit-switched high-speed end-to-end transport architecture

    NASA Astrophysics Data System (ADS)

    Veeraraghavan, Malathi; Zheng, Xuan; Lee, Hyuk; Gardner, M.; Feng, Wuchun

    2003-10-01

    Leveraging the dominance of Ethernet in LANs and SONET/SDH in MANs and WANs, we propose a service called CHEETAH (Circuit-switched High-speed End-to-End Transport ArcHitecture). The service concept is to provide end hosts with high-speed, end-to-end circuit connectivity on a call-by-call shared basis, where a "circuit" consists of Ethernet segments at the ends that are mapped into Ethernet-over-SONET long-distance circuits. This paper focuses on the file-transfer application for such circuits. For this application, the CHEETAH service is proposed as an add-on to the primary Internet access service already in place for enterprise hosts. This allows an end host that is sending a file to first attempt setting up an end-to-end Ethernet/EoS circuit, and if rejected, fall back to the TCP/IP path. If the circuit setup is successful, the end host will enjoy a much shorter file-transfer delay than on the TCP/IP path. To determine the conditions under which an end host with access to the CHEETAH service should attempt circuit setup, we analyze mean file-transfer delays as a function of call blocking probability in the circuit-switched network, probability of packet loss in the IP network, round-trip times, link rates, and so on.

  17. Programming languages for circuit design.

    PubMed

    Pedersen, Michael; Yordanov, Boyan

    2015-01-01

    This chapter provides an overview of a programming language for Genetic Engineering of Cells (GEC). A GEC program specifies a genetic circuit at a high level of abstraction through constraints on otherwise unspecified DNA parts. The GEC compiler then selects parts which satisfy the constraints from a given parts database. GEC further provides more conventional programming language constructs for abstraction, e.g., through modularity. The GEC language and compiler is available through a Web tool which also provides functionality, e.g., for simulation of designed circuits.

  18. A general waveguide circuit theory

    NASA Astrophysics Data System (ADS)

    Marks, Roger B.; Williams, Dylan F.

    1992-10-01

    This work generalizes and extends the classical circuit theory of electromagnetic waveguides. Unlike the conventional theory, the present formulation applies to all waveguides composed of linear, isotropic material, even those involving lossy conductors and hybrid mode fields, in a fully rigorous way. Special attention is given to distinguishing the traveling waves, constructed with respect to a well-defined characteristic impedance, from a set of pseudo-waves, defined with respect to an arbitrary reference impedance. Matrices characterizing a linear circuit are defined, and relationships among them, some newly discovered, are derived. New ramifications of reciprocity are developed. Measurement of various network parameters is given extensive treatment.

  19. Circuit breaker lock out assembly

    DOEpatents

    Gordy, W.T.

    1983-05-18

    A lock out assembly for a circuit breaker which consists of a generally step-shaped unitary base with an aperture in the small portion of the step-shaped base and a roughly S shaped retaining pin which loops through the large portion of the step-shaped base. The lock out assembly is adapted to fit over a circuit breaker with the handle switch projecting through the aperture, and the retaining pin projecting into an opening of the handle switch, preventing removal.

  20. Retropath: automated pipeline for embedded metabolic circuits.

    PubMed

    Carbonell, Pablo; Parutto, Pierre; Baudier, Claire; Junot, Christophe; Faulon, Jean-Loup

    2014-08-15

    Metabolic circuits are a promising alternative to other conventional genetic circuits as modular parts implementing functionalities required for synthetic biology applications. To date, metabolic design has been mainly focused on production circuits. Emergent applications such as smart therapeutics, however, require circuits that enable sensing and regulation. Here, we present RetroPath, an automated pipeline for embedded metabolic circuits that explores the circuit design space from a given set of specifications and selects the best circuits to implement based on desired constraints. Synthetic biology circuits embedded in a chassis organism that are capable of controlling the production, processing, sensing, and the release of specific molecules were enumerated in the metabolic space through a standard procedure. In that way, design and implementation of applications such as therapeutic circuits that autonomously diagnose and treat disease, are enabled, and their optimization is streamlined.

  1. Derivation of Neural Circuits from the Similarity Matching Principle

    NASA Astrophysics Data System (ADS)

    Pehlevan, Cengiz; Chklovskii, Dmitri

    Our brains analyze high-dimensional datasets streamed by our sensory organs in multiple stages. Sensory cortices, for example, perform tasks like dimensionality reduction, sparse feature discovery and clustering. To model these tasks we pursue an approach analogous to use of action principles in physics and propose a new family of objective functions based on the principle of similarity matching. From these objective functions we derive online distributed algorithms that can be implemented by biological neural networks resembling cortical circuits. Our networks can adapt to changes in the number of latent dimensions or the number of clusters in the input dataset. Furthermore, we formulate minimax optimization problems from which we derive online algorithms with two classes of neurons identified with principal neurons and interneurons in biological circuits. In addition to bearing resemblance to biological circuits, our algorithms are competitive for Big Data applications.

  2. 30 CFR 75.901 - Protection of low- and medium-voltage three-phase circuits used underground.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... relay must be set to cause the circuit interrupting device that supplies power to the primary windings... a suitable resistor at the power center, and a grounding circuit, originating at the grounded side of the grounding resistor, shall extend along with the power conductors and serve as a...

  3. Dose and linear energy transfer distributions of primary and secondary particles in carbon ion radiation therapy: A Monte Carlo simulation study in water

    PubMed Central

    Johnson, Daniel; Chen, Yong; Ahmad, Salahuddin

    2015-01-01

    The factors influencing carbon ion therapy can be predicted from accurate knowledge about the production of secondary particles from the interaction of carbon ions in water/tissue-like materials, and subsequently the interaction of the secondary particles in the same materials. The secondary particles may have linear energy transfer (LET) values that potentially increase the relative biological effectiveness of the beam. Our primary objective in this study was to classify and quantify the secondary particles produced, their dose averaged LETs, and their dose contributions in the absorbing material. A 1 mm diameter carbon ion pencil beam with energies per nucleon of 155, 262, and 369 MeV was used in a geometry and tracking 4 Monte Carlo simulation to interact in a 27 L water phantom containing 3000 rectangular detector voxels. The dose-averaged LET and the dose contributions of primary and secondary particles were calculated from the simulation. The results of the simulations show that the secondary particles that contributed a major dose component had LETs <100 keV/µm. The secondary particles with LETs >600 keV/µm contributed only <0.3% of the dose. PMID:26865757

  4. Mixed Electromagnetic and Circuit Simulations using Higher-Order Elements and Bases

    SciTech Connect

    Champagne, N J; Rockway, J D; Jandhyala, V

    2003-06-18

    In this paper, an approach to couple higher-order electromagnetic surface integral equations to circuit simulations is presented. Terminals are defined that connect circuit elements to contacts modeled on the distributed electromagnetic domain. A modified charge-current continuity equation is proposed for a generalized KCL connection at the contacts. The distributive electromagnetic integral equations are developed using higher-order bases and elements that allow both better convergence and accuracy for modeling. The resulting scheme enables simultaneous solution of electromagnetic integral equations for arbitrarily-shaped objects and SPICE-like modeling for lumped circuits, and permits design iterations and visualization of the interaction between the two domains.

  5. MOS integrated circuit fault modeling

    NASA Technical Reports Server (NTRS)

    Sievers, M.

    1985-01-01

    Three digital simulation techniques for MOS integrated circuit faults were examined. These techniques embody a hierarchy of complexity bracketing the range of simulation levels. The digital approaches are: transistor-level, connector-switch-attenuator level, and gate level. The advantages and disadvantages are discussed. Failure characteristics are also described.

  6. Variable magnetic circuit torque sensor

    NASA Astrophysics Data System (ADS)

    Lemarquand, G.; Lemarquand, V.

    1991-11-01

    This paper presents an original torque sensor structure using the properties of magnetic circuits, including permanent magnets. The torque is measured through the torsion of the transmitting shaft. The torsion is proportional to the torque. Considering two points of the shaft on the same line in absence of torque, the information is given by the twisting angle in the presence of a torque. A rotating magnetic circuit yields an angle representative signal. This circuit is deformed by the shaft torsion. The reluctance varies and so does the magnet operating point. The induction is measured in an airgap by a statoric galvanomagnetic device. The magnetic field source is an axial permanent magnet ring. Two iron-toothed rings, fixed to the driving and driven part of the shaft, respectively, and separated by an airgap make up the variable part of the magnetic circuit. The teeth get out of line whenever a torque is applied. The galvanomagnetic device measures an uniform induction and so delivers a modulation free signal, i.e., rotation independent. Because of the periodic toothed structure, the induction varies periodically with the twisting angle. The sense of the variation is the same over half a period or half a pitch. The variation form depends on the teeth design. Operating interval is to be chosen equal to or smaller than the half pitch.

  7. Circuit theory of Andreev conductance

    NASA Astrophysics Data System (ADS)

    Nazarov, Yuli V.

    1994-09-01

    Conductance of small normal metal structures adjacent to a superconductor is determined by coherent Andreev reflection. We show that under certain limitations the conductance can be found by means of an extended circuit theory. The theory deals with two types of elements: tunnel junctions and diffusive conductors and provides the basis for practical calculations. A new device proposed illustrates the advantages of the theory.

  8. Integrated Circuit Stellar Magnitude Simulator

    ERIC Educational Resources Information Center

    Blackburn, James A.

    1978-01-01

    Describes an electronic circuit which can be used to demonstrate the stellar magnitude scale. Six rectangular light-emitting diodes with independently adjustable duty cycles represent stars of magnitudes 1 through 6. Experimentally verifies the logarithmic response of the eye. (Author/GA)

  9. Advanced Imaging of Elementary Circuits

    ERIC Educational Resources Information Center

    Baird, William H.; Richards, Caleb; Godbole, Pranav

    2012-01-01

    Students commonly find the second semester of introductory physics to be more challenging than the first, probably due to the mechanical intuition we acquire just by moving around. For most students, there is no similar comfort with electricity or magnetism. In an effort to combat this confusion, we decided to examine simple electric circuits with…

  10. No-warp potted circuits

    NASA Technical Reports Server (NTRS)

    Robinson, W. W.

    1979-01-01

    Sponge inserts compensate for potting-compound expansion and relieve thermal stresses on circuit boards. Technique quality of production runs on PC boards intended for applications in environments less severe than those for aerospace equipment. Pads reduce weight of modules because they weigh far less than potting compound they displace.

  11. Low-frequency attenuator circuit

    NASA Technical Reports Server (NTRS)

    Cash, W. H., Jr.; Polyhemus, J. T.

    1979-01-01

    Circuit uses only single operational amplifier and few passive components to remove background noise from miniature "wristwatch" pulse detector. It can be applied to other systems where background noise is slowly varying, such as ultrasonics, strain-gage sensors, and accelerometers.

  12. Development of CMOS integrated circuits

    NASA Technical Reports Server (NTRS)

    Bertino, F.; Feller, A.; Greenhouse, J.; Lombardi, T.; Merriam, A.; Noto, R.; Ozga, S.; Pryor, R.; Ramondetta, P.; Smith, A.

    1979-01-01

    Report documents life cycles of two custom CMOS integrated circuits: (1) 4-bit multiplexed register with shift left and shift right capabilities, and (2) dual 4-bit registers. Cycles described include conception as logic diagrams through design, fabrication, testing, and delivery.

  13. View of first bank of circuit towers on Arizona side ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of first bank of circuit towers on Arizona side of canyon. Left tower supports Circuit 12, second from left tower supports Circuit 11, middle tower supports Circuit 10, second from right tower supports Circuit 9, and right tower supports Circuit 8, view west - Hoover Dam, Circuits 1-15, U.S. Highway 93, Boulder City, Clark County, NV

  14. Effects of 5-fluorouracil in nuclear and cellular morphology, proliferation, cell cycle, apoptosis, cytoskeletal and caveolar distribution in primary cultures of smooth muscle cells.

    PubMed

    Filgueiras, Marcelo de Carvalho; Morrot, Alexandre; Soares, Pedro Marcos Gomes; Costa, Manoel Luis; Mermelstein, Cláudia

    2013-01-01

    Colon cancer is one of the most prevalent types of cancer in the world and is one of the leading causes of cancer death. The anti-metabolite 5- fluorouracil (5-FU) is widely used in the treatment of patients with colon cancer and other cancer types. 5-FU-based chemotherapy has been shown to be very efficient in the improvement of overall survival of the patients and for the eradication of the disease. Unfortunately, common side effects of 5-FU include severe alterations in the motility of the gastrointestinal tissues. Nevertheless, the molecular and cellular effects of 5-FU in smooth muscle cells are poorly understood. Primary smooth muscle cell cultures are an important tool for studies of the biological consequences of 5-FU at the cellular level. The avian gizzard is one of the most robust organs of smooth muscle cells. Here we studied the molecular and cellular effects of the chemotherapic drug 5-FU in a primary culture of chick gizzard smooth muscle cells. We found that treatment of smooth muscle cells with 5-FU inhibits cell proliferation by the arrest of cells in the G1 phase of cell cycle and induce apoptosis. 5-FU induced a decrease in the percentage of histone H3-positive cells. Treatment of cells with 5-FU induced changes in cellular and nuclear morphology, a decrease in the number of stress fibers and a major decrease in the number of caveolin-3 positive cells. Our results suggest that the disorganization of the actin cytoskeleton and the reduction of caveolin-3 expression could explain the alterations in contractility observed in patients treated with 5-FU. These findings might have an impact in the understanding of the cellular effects of 5-FU in smooth muscle tissues and might help the improvement of new therapeutic protocols for the treatment of colon cancer.

  15. Circuit Theory in Ballistic Conducting Channel

    NASA Astrophysics Data System (ADS)

    Isawa, Yoshimasa

    1996-11-01

    A new approach to derive the Landauer formula is developed by treating the current flowing ballistic conducting channel as an open system, in which an electronic distribution function shifts in proportion to an external current flow. The effect of an open system is taken into account by means of the Lagrange multiplier. By introducing current reflection and transmission coefficients, and by explicitly treating the voltage drop under the condition that the contact between the lead and the electrode is ideal, two types of circuit equations corresponding to two Landauer formulas are obtained. In our analysis, the Landauer formula is not reproduced when there are no scattering centers in each lead, i.e., each lead is ideal, but is reproduced when there is no elastic scattering and the phase coherence is lost in each lead.

  16. Fabric circuits and method of manufacturing fabric circuits

    NASA Technical Reports Server (NTRS)

    Chu, Andrew W. (Inventor); Dobbins, Justin A. (Inventor); Scully, Robert C. (Inventor); Trevino, Robert C. (Inventor); Lin, Greg Y. (Inventor); Fink, Patrick W. (Inventor)

    2011-01-01

    A flexible, fabric-based circuit comprises a non-conductive flexible layer of fabric and a conductive flexible layer of fabric adjacent thereto. A non-conductive thread, an adhesive, and/or other means may be used for attaching the conductive layer to the non-conductive layer. In some embodiments, the layers are attached by a computer-driven embroidery machine at pre-determined portions or locations in accordance with a pre-determined attachment layout before automated cutting. In some other embodiments, an automated milling machine or a computer-driven laser using a pre-designed circuit trace as a template cuts the conductive layer so as to separate an undesired portion of the conductive layer from a desired portion of the conductive layer. Additional layers of conductive fabric may be attached in some embodiments to form a multi-layer construct.

  17. Different IgG-subclass distributions after whole-cell and acellular pertussis infant primary vaccinations in healthy and pertussis infected children.

    PubMed

    Hendrikx, Lotte H; Schure, Rose-Minke; Oztürk, Kemal; de Rond, Lia G H; de Greeff, S C; Sanders, Elisabeth A M; Berbers, Guy A M; Buisman, Anne-Marie

    2011-09-16

    The distribution of IgG-subclasses provides insight in the immunological mechanisms of protection against whooping cough. We investigated the effect of Dutch whole-cell pertussis and acellular pertussis vaccines administered in infancy on the IgG-subclass distributions in healthy children aged 12 months, 4 years and 9 years as well as in children who have been infected with Bordetella pertussis. A fluorescent bead-based multiplex immunoassay was used for the measurement of IgG1, IgG2, IgG3 and IgG4 responses against pertussis toxin, filamentous heamagglutinin and pertactin. Although IgG1 was the predominant subclass for all pertussis antigens in both healthy and infected children, elevated IgG4 levels were only present in children who had received repeated number of acellular pertussis vaccinations. IgG2 and IgG3 antibodies did not contribute to the IgG response. No differences in IgG-subclasses between healthy vaccinated or infected children were found. The pertussis vaccine used for priming seems to determine the IgG-subclass composition elicited after a secondary antibody response either induced by pertussis vaccination or infection. The pronounced anti-pertussis IgG4 response might reflect the Th2-skewing of the immune response after aP vaccination.

  18. Simple, one transistor circuit boosts pulse amplitude

    NASA Technical Reports Server (NTRS)

    Keon, T.; Matchett, M. W.

    1966-01-01

    Simple circuit that uses a single transistor to accomplish capacitor storage followed by common-base switching supplies a pulse voltage, higher than that normally available from emitter-follower circuits, to drive a 100-watt transmitter.

  19. Driver circuit for solid state light sources

    DOEpatents

    Palmer, Fred; Denvir, Kerry; Allen, Steven

    2016-02-16

    A driver circuit for a light source including one or more solid state light sources, a luminaire including the same, and a method of so driving the solid state light sources are provided. The driver circuit includes a rectifier circuit that receives an alternating current (AC) input voltage and provides a rectified AC voltage. The driver circuit also includes a switching converter circuit coupled to the light source. The switching converter circuit provides a direct current (DC) output to the light source in response to the rectified AC voltage. The driver circuit also includes a mixing circuit, coupled to the light source, to switch current through at least one solid state light source of the light source in response to each of a plurality of consecutive half-waves of the rectified AC voltage.

  20. Post regulation circuit with energy storage

    DOEpatents

    Ball, Don G.; Birx, Daniel L.; Cook, Edward G.

    1992-01-01

    A charge regulation circuit provides regulation of an unregulated voltage supply and provides energy storage. The charge regulation circuit according to the present invention provides energy storage without unnecessary dissipation of energy through a resistor as in prior art approaches.