75 FR 77741 - Federal Acquisition Regulation; Limitation on Pass-Through Charges

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-13

... of content, contact Mr. Edward Chambers, Procurement Analyst, at (202) 501-3221. For information...: November 24, 2010. Millisa Gary, Acting Director, Acquisition Policy Division. Interim Rule Adopted as...

Southwestern Power Administration Update, October- December 2004

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2004-12-01

On October 29, 2004, Southwestern and Southwest Power Pool, Inc. (SPP) reached agreement on interim arrangements to be implemented after the October 31, 2004, expiration of the membership agreement between the two parties. According to Jim McDonald, Director of Southwestern’s Division of Customer Service, the interim agreement forged between Southwestern and SPP seeks to minimize impacts to SPP as well as to Southwestern and its customers while Southwestern and SPP work on a seams/coordination agreement to succeed the expired membership agreement.

Compendium of Dental Residents’ Research Projects and Literature Reviews - 1990

DTIC Science & Technology

1991-03-01

AL-SR-1991-0001 AD-A236 272 COMPENDIUM OF DENTAL RESIDENTS’ RESEARCH PROJECTS AND LITERATURE REVIEWS 1990 CDTIC JNO 6INSi3 Samuel P. Davis...USAF Dental Investigation Service Armstrong Laboratory Human Systems Division (AFSC) 91-01146 Brooks Air Force Base, TX 78235-5000 .,....,,.,,.l. ltfl 91...L, / 041 4li NOTICES This interim special report was submitted by personnel of the Dental Investigation Service, Clinical Sciences Division

Evaluation of rubber-asphalt chip seal in Oregon : interim report.

DOT National Transportation Integrated Search

1977-05-01

The Oregon State Highway Division, in cooperation with the Federal Highway Administration, participated in a demonstration project on the evaluation of rubber-asphalt chip seals. The trial projects were placed in Maintenance District 11, in the vicin...

Evapotranspiration Cover for the 92-Acre Area Retired Mixed Waste Pits:Interim CQA Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

The Delphi Groupe, Inc., and J. A. Cesare and Associates, Inc.

This Interim Construction Quality Assurance (CQA) Report is for the 92-Acre Evapotranspiration Cover, Area 5 Waste Management Division (WMD) Retired Mixed Waste Pits, Nevada National Security Site, Nevada for the period of January 20, 2011 to May 12, 2011. This Interim Construction Quality Assurance (CQA) Report is for the 92-Acre Evapotranspiration Cover, Area 5 Waste Management Division (WMD) Retired Mixed Waste Pits, Nevada National Security Site, Nevada for the period of January 20, 2011 to May 12, 2011. Construction was approved by the Nevada Division of Environmental Protection (NDEP) under the Approval of Corrective Action Decision Document/Corrective Action Plan (CADD/CAP)more » for Corrective Action Unit (CAU) 111: Area 5 WMD Retired Mixed Waste Pits, Nevada National Security Site, Nevada, on January 6, 2011, pursuant to Subpart XII.8a of the Federal Facility Agreement and Consent Order. The project is located in Area 5 of the Radioactive Waste Management Complex (RWMC) at the Nevada National Security Site (NNSS), formerly known as the Nevada Test Site, located in southern Nevada, approximately 65 miles northwest of Las Vegas, Nevada, in Nye County. The project site, in Area 5, is located in a topographically closed basin approximately 14 additional miles north of Mercury Nevada, in the north-central part of Frenchman Flat. The Area 5 RWMS uses engineered shallow-land burial cells to dispose of packaged waste. The 92-Acre Area encompasses the southern portion of the Area 5 RWMS, which has been designated for the first final closure operations. This area contains 13 Greater Confinement Disposal (GCD) boreholes, 16 narrow trenches, and 9 broader pits. With the exception of two active pits (P03 and P06), all trenches and pits in the 92-Acre Area had operational covers approximately 2.4 meters thick, at a minimum, in most areas when this project began. The units within the 92-Acre Area are grouped into the following six informal categories based on physical location, waste types and regulatory requirements: (1) Pit 3 Mixed Waste Disposal Unit (MWDU); (2) Corrective Action Unit (CAU) 111; (3) CAU 207; (4) Low-level waste disposal units; (5) Asbestiform low-level waste disposal units; and (6) One transuranic (TRU) waste trench.« less

Aligned Carbon Nanotube Carpets on Carbon Substrates for High Power Electronic Applications

DTIC Science & Technology

2016-06-01

SiOx by a vapor-solid-solid mechanism ,” J. Am. Chem. Soc., vol. 133, pp. 197–199, 2011. [146] B. Liu, W. Ren, C. Liu, C.-H. Sun , L. Gao, S. Li, C... Mechanical and Thermal Systems Branch Power and Control Division JUNE 2016 Interim Report DISTRIBUTION STATEMENT A: Approved for public release...Advisor Program Engineer Mechanical and Thermal Systems Branch Mechanical and Thermal Systems Branch Power and Control Division Power and Control

Type A polymer concrete overlay field trials : interim report.

DOT National Transportation Integrated Search

1982-12-01

On July 31 and August 1, 1982, the Oregon State Highway Division successfully placed a methyl methacrylate polymer concrete overlay on a portion of one span of a major interchange ramp in Portland, Oregon. Two proprietary polymer concretes were used ...

Functional design criteria for interim stabilization safety class 1 trip circuit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larson, R.E., Westinghouse Hanford

1996-06-10

This Functional Design Criteria document outlines the basic requirements for the Safety Class 1 Trip Circuit. The objective of the Safety Class 1 Trip Circuit is to isolate the power circuitry to the Class 1 Division 2, Group B or lesser grade electrically fed loads located in the pump pit. The electrically fed load circuits need to have power isolated to them upon receipt of the following conditions, loss of flammable gases being released (above a predetermined threshold), and seismic(greater than 0.12g acceleration) activity. The two circuits requiring power isolation are the pump and heat trace power circuits. The Safetymore » Class 1 Trip Circuit will be used to support salt well pumping in SST`s containing potentially flammable gas-bearing / gas-producing radioactive waste.« less

Potential benefits of adding emulsion to reclaimed base material : interim report, second year.

DOT National Transportation Integrated Search

1999-09-01

Rehabilitation of deteriorated asphalt pavements has become one of the primary tools utilized by : the Construction Division of the Maine Department of Transportation (MDOT). One method : used to achieve this task is the use of pavement reclaiming. :...

Interim reliability-evaluation program: analysis of the Browns Ferry, Unit 1, nuclear plant. Appendix C - sequence quantification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mays, S.E.; Poloski, J.P.; Sullivan, W.H.

1982-07-01

This report describes a risk study of the Browns Ferry, Unit 1, nuclear plant. The study is one of four such studies sponsored by the NRC Office of Research, Division of Risk Assessment, as part of its Interim Reliability Evaluation Program (IREP), Phase II. This report is contained in four volumes: a main report and three appendixes. Appendix C generally describes the methods used to estimate accident sequence frequency values. Information is presented concerning the approach, example collection, failure data, candidate dominant sequences, uncertainty analysis, and sensitivity analysis.

Petrotac bridge deck waterproofing membrane on Five Mile Creek Bridge : first interim report.

DOT National Transportation Integrated Search

1986-09-01

During the 1970's, the Oregon State Highway Division was involved in a Federally funded experimental program to evaluate various waterproofing membrane systems for bridge decks. Through this program, a list of approved products and/or systems was dev...

High performance concrete in Washington state SR 18/SR 516 overcrossing : interim report on girder monitoring

DOT National Transportation Integrated Search

1999-04-30

This report documents a sample of heavy-duty truck activity. This research effort was originated by the Planning and Technical Support Division of the California Air Resources Board (CARB) and jointly supported by the Federal Highway Administration (...

75 FR 742 - Temporary Rule Regarding Principal Trades With Certain Advisory Clients

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-06

... , Office of Investment Adviser Regulation, Division of Investment Management, Securities and Exchange... the Investment Advisers Act of 1940, the interim final temporary rule that establishes an alternative means for investment advisers who are registered with the Commission as broker-dealers to meet the...

76 FR 9381 - Notice of Availability of Interim Staff Guidance Documents for Spent Fuel Storage Casks

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-17

.... FOR FURTHER INFORMATION CONTACT: Matthew Gordon, Structural Mechanics and Materials Branch, Division... a fee. Comments and questions on ISG-23 should be directed to Matthew Gordon, Structural Mechanics..., 2011. For the U.S. Nuclear Regulatory Commission. Michele Sampson, Acting Chief, Structural Mechanics...

Protocol for determining bull trout presence

Treesearch

James Peterson; Jason B. Dunham; Philip Howell; Russell Thurow; Scott Bonar

2002-01-01

The Western Division of the American Fisheries Society was requested to develop protocols for determining presence/absence and potential habitat suitability for bull trout. The general approach adopted is similar to the process for the marbled murrelet, whereby interim guidelines are initially used, and the protocols are subsequently refined as data are collected....

CETA Demonstration Provides Lessons On Implementing Youth Programs.

DTIC Science & Technology

1980-12-08

private sector participation, and labor market effects. In addition to a series of reports on specific issues and additional interim reports, MDRC...im, Mr. Gregory J. Ahat 4 1""yDm Director Alian Kotler Human Resources Division IDurid Ihuir U.S. General Accounting Office (.ijbr’E Sfrrw

77 FR 20536 - Exemptions for Security-Based Swaps Issued by Certain Clearing Agencies

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-05

... Markets Trends, Division of Corporation Finance, at (202) 551-3860, U.S. Securities and Exchange... exchange trading due to individual business needs of certain users. Those users should retain the ability... Corporation Finance issued a no-action letter that addressed the availability of these interim exemptions to...

An evaluation of the impact of the Virginia driver improvement program on negligent driving : 12-month report [interim report].

DOT National Transportation Integrated Search

1982-01-01

This study sought to evaluate the impact of the four basic treatment combinations of the rehabilitation component of the Virginia driver improvement program. It was found that receipt of a warning letter from the Division of Motor Vehicles had no eff...

75 FR 53353 - Notice of Availability of Final Interim Staff Guidance Document No. 25 “Pressure and Helium...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-31

... Guidance Document No. 25 ``Pressure and Helium Leakage Testing of the Confinement Boundary of Spent Fuel...: The Division of Spent Fuel Storage and Transportation (SFST) of the Office of Nuclear Materials Safety... Helium Leakage Testing of the Confinement Boundary of Spent Fuel Dry Storage Systems.'' This ISG...

Human-Machine Teams: The Social Frontier

DTIC Science & Technology

2015-12-01

Trust & Interaction Branch December 2015 Interim Report Distribution A. Approved for public release AIR FORCE RESEARCH LABORATORY 711TH HUMAN...711th Human Performance Wing Air Force Research Laboratory This report is published in the interest of scientific and technical information exchange... Research Laboratory 711th Human Performance Wing Human Effectiveness Directorate Human Centered ISR Division Human Trust & Interaction Branch Wright

77 FR 31237 - Electronic Filing in the Copyright Office of Notices of Intention To Obtain a Section 115...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... multiple nondramatic musical works may be submitted electronically as XML files. Electronically submitted Notices will be maintained in a database that can be searched using any of the included fields of... the Licensing Division for a search of the database during the interim period. As such, the Office...

Grant Izmirlian, PhD | Division of Cancer Prevention

Cancer.gov

Dr. Grant Izmirian has worked on methodology for monitoring clinical trials, conducting formal interim analyses for the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial and the National Lung Screening Trial (NLST). These analyses were nonstandard in nature and required a subject matter expert because of the presumed delay in the effect of screening. He also

Interim reliability-evaluation program: analysis of the Browns Ferry, Unit 1, nuclear plant. Appendix B - system descriptions and fault trees

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mays, S.E.; Poloski, J.P.; Sullivan, W.H.

1982-07-01

This report describes a risk study of the Browns Ferry, Unit 1, nuclear plant. The study is one of four such studies sponsored by the NRC Office of Research, Division of Risk Assessment, as part of its Interim Reliability Evaluation Program (IREP), Phase II. This report is contained in four volumes: a main report and three appendixes. Appendix B provides a description of Browns Ferry, Unit 1, plant systems and the failure evaluation of those systems as they apply to accidents at Browns Ferry. Information is presented concerning front-line system fault analysis; support system fault analysis; human error models andmore » probabilities; and generic control circuit analyses.« less

75 FR 53153 - Federal Acquisition Regulation; American Recovery and Reinvestment Act of 2009 (the Recovery Act...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

...The Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (the Councils) have adopted as final, with changes, an interim rule amending the Federal Acquisition Regulation (FAR) to implement the American Recovery and Reinvestment Act of 2009 (Recovery Act) with respect to the ``Buy American--Recovery Act'' provision, section 1605 in Division A.

Environmental Enrichment Protects against Functional Deficits caused by Traumatic Brain Injury

DTIC Science & Technology

2012-11-01

Herman University of Cincinnati November 2012 Interim Report AIR FORCE RESEARCH LABORATORY 711 HUMAN PERFORMANCE WING, HUMAN EFFECTIVENESS DIRECTORATE...Chief, Warfighter Interface Division Human Effectiveness Directorate 711 Human Performance Wing Air Force Research Laboratory This report is published...MONITOR’S ACRONYM(S) Air Force Materiel Command Air Force Research Laboratory 711th Human Performance Wing Human Effectiveness Directorate Warfighter

(US low-level radioactive waste management facility design, construction, and operation): Foreign trip report, July 22--30, 1989

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Hoesen, S.D.; Bolinsky, J.

1989-08-02

The Martin Marietta Energy Systems, Inc., Team, consisting of representatives of the Engineering Division and Oak Ridge National Laboratory (ORNL), participated in a technology exchange program on French and US low-level radioactive waste (LLW) management facility design, construction, and operation. Meetings were held at the Agence National pour la Gestion des Dechets Radioactif (ANDRA) offices in Paris to review the designs for the new French LLW disposal facility, the Cente de Stockage de l'Aube (CSA), and the new ORNL LLW disposal project, the Interim Waste Management Facility (IWMF), and the results of the French LLW disposal facility cover experiment atmore » St. Sauveur. Visits were made to the operating LLW disposal facility, the Centre de Stockage de la Manche (CSM), the LLW conditioning facilities at the La Hague Reprocessing Facility, and the St. Saueveur Disposal Cap Experiment to discuss design, construction, and operating experience. A visit was also made to the CSA site to view the progress made in construction of the new facility.« less

Validation of the MEPDG transfer functions using the LTPP test sections in Georgia task 2 interim report.

DOT National Transportation Integrated Search

2013-07-16

The Georgia Department of Transportation (GDOT) is transitioning from empirical design procedures to the MEPDG : procedure for designing new and rehabilitated highway pavements. GDOT currently uses the 1972 AASHTO Interim : Guide for Design of Paveme...

CMM Interim Check Design of Experiments (U)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montano, Joshua Daniel

2015-07-29

Coordinate Measuring Machines (CMM) are widely used in industry, throughout the Nuclear Weapons Complex and at Los Alamos National Laboratory (LANL) to verify part conformance to design definition. Calibration cycles for CMMs at LANL are predominantly one year in length and include a weekly interim check to reduce risk. The CMM interim check makes use of Renishaw’s Machine Checking Gauge which is an off-the-shelf product simulates a large sphere within a CMM’s measurement volume and allows for error estimation. As verification on the interim check process a design of experiments investigation was proposed to test a couple of key factorsmore » (location and inspector). The results from the two-factor factorial experiment proved that location influenced results more than the inspector or interaction.« less

Project ARTEMIS. High Power Acoustic Source. Interim Report on Acoustic Performance (Second)

DTIC Science & Technology

1961-09-19

DIVISION 19 September 1961 0 OCT 25, 977 H • •€ US. N•ATAL RESEARICH LADO RATORY• ’• ? 7: .•....• ~•,. .c. ,,,- WabGgt u D.C. UIW 12O8"StjI -J1--; 0, rot...trans- ducer eleiments. Minor var-Atiens in displacement roused by differ- ences in individual elementt or by normal pressure patterns, would be

Conceptual design statement of work for the immobilized low-activity waste interim storage facility project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlson, T.A., Fluor Daniel Hanford

1997-02-06

The Immobilized Low-Activity Waste Interim Storage subproject will provide storage capacity for immobilized low-activity waste product sold to the U.S. Department of Energy by the privatization contractor. This statement of work describes the work scope (encompassing definition of new installations and retrofit modifications to four existing grout vaults), to be performed by the Architect-Engineer, in preparation of a conceptual design for the Immobilized Low-Activity Waste Interim Storage Facility.

Accounting for interim safety monitoring of an adverse event upon termination of a clinical trial.

PubMed

Dallas, Michael J

2008-01-01

Upon termination of a clinical trial that uses interim evaluations to determine whether the trial can be stopped, a proper statistical analysis must account for the interim evaluations. For example, in a group-sequential design where the efficacy of a treatment regimen is evaluated at interim stages, and the opportunity to stop the trial based on positive efficacy findings exists, the terminal p-value, point estimate, and confidence limits of the outcome of interest must be adjusted to eliminate bias. While it is standard practice to adjust terminal statistical analyses due to opportunities to stop for "positive" findings, adjusting due to opportunities to stop for "negative" findings is also important. Stopping rules for negative findings are particularly useful when monitoring a specific rare serious adverse event in trials designed to show safety with respect to the event. In these settings, establishing conservative stopping rules are appropriate, and therefore accounting for the interim monitoring can have a substantial effect on the final results. Here I present a method to account for interim safety monitoring and illustrate its usefulness. The method is demonstrated to have advantages over methodology that does not account for interim monitoring.

46 CFR 153.482 - Stripping quantities and interim standards for Category C NLS tanks on ships built before July 1...

Code of Federal Regulations, 2013 CFR

2013-10-01

... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Design and Equipment for Pollution Control § 153.482 Stripping quantities and interim standards for Category C NLS tanks on...

46 CFR 153.482 - Stripping quantities and interim standards for Category C NLS tanks on ships built before July 1...

Code of Federal Regulations, 2012 CFR

2012-10-01

... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Design and Equipment for Pollution Control § 153.482 Stripping quantities and interim standards for Category C NLS tanks on...

46 CFR 153.482 - Stripping quantities and interim standards for Category C NLS tanks on ships built before July 1...

Code of Federal Regulations, 2014 CFR

2014-10-01

... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Design and Equipment for Pollution Control § 153.482 Stripping quantities and interim standards for Category C NLS tanks on...

46 CFR 153.482 - Stripping quantities and interim standards for Category C NLS tanks on ships built before July 1...

Code of Federal Regulations, 2011 CFR

2011-10-01

... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Design and Equipment for Pollution Control § 153.482 Stripping quantities and interim standards for Category C NLS tanks on...

46 CFR 153.482 - Stripping quantities and interim standards for Category C NLS tanks on ships built before July 1...

Code of Federal Regulations, 2010 CFR

2010-10-01

... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Design and Equipment for Pollution Control § 153.482 Stripping quantities and interim standards for Category C NLS tanks on...

A phase II flexible screening design allowing for interim analysis and comparison with historical control.

PubMed

Wu, Wenting; Bot, Brian; Hu, Yan; Geyer, Susan M; Sargent, Daniel J

2013-07-01

Sargent and Goldberg [1] proposed a randomized phase II flexible screening design (SG design) which took multiple characteristics of candidate regimens into consideration in selecting a regimen for further phase III testing. In this paper, we extend the SG design by including provisions for an interim analysis and/or a comparison to a historical control. By including a comparison with a historical control, a modified SG design not only identifies a more promising treatment but also assures that the regimen has a clinically meaningful level of efficacy as compared to a historical control. By including an interim analysis, a modified SG design could reduce the number of patients exposed to inferior treatment regimens. When compared to the original SG design, the modified designs increase the sample size moderately, but expand the utility of the flexible screening design substantially. Copyright © 2013 Elsevier Inc. All rights reserved.

Imperatives for Effective Post-Conflict Reconstruction Contracting

DTIC Science & Technology

2007-03-15

the transfer of authority from the CPA to the Interim Iraqi Government ( IIG ) in June 2004, the PMO was disestablished. All remaining DFI funds were...turned over the IIG . The Project and Contracting Office (PCO), another ad-hoc temporary organization was created and given the responsibility for...500K for division commanders with respective single transaction limits of $50K and $100K, respectively; weekly reporting; and for projects greater than

37 CFR 201.38 - Designation of agent to receive notification of claimed infringement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... person signing the Notice, and by the date of signature. (e) Filing. A service provider may file the.... The Copyright Office does not provide printed forms for filing an Interim Designation of Agent to... shall be accompanied by a filing fee for Recordation of an Interim Designation of Agent to Receive...

Planning and Designing School Computer Facilities. Interim Report.

ERIC Educational Resources Information Center

Alberta Dept. of Education, Edmonton. Finance and Administration Div.

This publication provides suggestions and considerations that may be useful for school jurisdictions developing facilities for computers in schools. An interim report for both use and review, it is intended to assist school system planners in clarifying the specifications needed by the architects, other design consultants, and purchasers involved.…

78 FR 24331 - Apricots Grown in Designated Counties in Washington; Temporary Suspension of Handling Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-25

... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 922 [Docket No. AMS-FV-12-0028... Regulations AGENCY: Agricultural Marketing Service, USDA. ACTION: Affirmation of interim rule as final rule... the marketing order for apricots grown in designated Counties in Washington. The interim rule...

Development of Titanium Alloy Casting Technology

DTIC Science & Technology

1976-08-01

reduction in melting temperatures (Table 8). (3 0 )Smeltzer, C.E., and Compton, W.A., "Titanium Braze System for High Temperature Applications", First...Compton, W. A., "Titanium Braze System for High Temperature Applications," First Interim Technical Report, Solar Division of International Harvester Co...Microstructures of the Phase 1I Ti-13Cu Alloy (Meat 2LO56) Showing the Effect of Various Aging Treatments After High Temperature Annealing 113 xi

Interim Service ISDN Satellite (ISIS) network model for advanced satellite designs and experiments

NASA Technical Reports Server (NTRS)

Pepin, Gerard R.; Hager, E. Paul

1991-01-01

The Interim Service Integrated Services Digital Network (ISDN) Satellite (ISIS) Network Model for Advanced Satellite Designs and Experiments describes a model suitable for discrete event simulations. A top-down model design uses the Advanced Communications Technology Satellite (ACTS) as its basis. The ISDN modeling abstractions are added to permit the determination and performance for the NASA Satellite Communications Research (SCAR) Program.

The Family and Medical Leave Act of 1993--Wage and Hour Division, Department of Labor. Interim final rule; request for comments.

PubMed

1993-06-04

This document contains interim regulations implementing the Family and Medical Leave Act of 1993 called ("FMLA" or "the Act"). The Act is effective on August 5, 1993, six months from the date of its enactment. Where a collective bargaining agreement is in effect on August 5, 1993, the Act is effective when the collective bargaining agreement terminates or February 5, 1994, whichever is earlier. The purpose of these regulations is to set forth the requirements of Title I and Title IV of the Act. Title I applies to covered private employers and public agencies (except for most of the Federal Government, which is governed by Title II). Title IV of the Act primarily concerns the relationship between FMLA and other laws, as well as collective bargaining agreements and other employer plans and programs.

Designing Their Own: Increasing Urban High School Teacher Capacity for Creating Interim Assessments

ERIC Educational Resources Information Center

Ado, Kathryn

2013-01-01

This case study analyzes and documents factors that affect teacher learning and instructional practices in connection to the design your own (DYO) interim or periodic assessment process at one newly developed high school in New York City. Examining these factors through Riggan and Nabors Olah's (2011) conceptual framework offers insights into the…

The role of the Data and Safety Monitoring Board in a clinical trial: The CRISIS Study

PubMed Central

Holubkov, Richard; Casper, T. Charles; Dean, J. Michael; Anand, K. J. S.; Zimmerman, Jerry; Meert, Kathleen L.; Newth, Christopher J. L.; Berger, John; Harrison, Rick; Willson, Douglas F.; Nicholson, Carol

2012-01-01

Objective Randomized clinical trials are commonly overseen by a data and safety monitoring board (DSMB) comprised of experts in medicine, ethics, and biostatistics. DSMB responsibilities include protocol approval, interim review of study enrollment, protocol compliance, safety, and efficacy data. DSMB decisions can affect study design and conduct, as well as reported findings. Researchers must incorporate DSMB oversight into the design, monitoring, and reporting of randomized trials. Design Case study, narrative review. Methods The DSMB’s role during the comparative pediatric Critical Illness Stress-Induced Immune Suppression (CRISIS) Prevention Trial is described. Findings The NIH-appointed CRISIS DSMB was charged with monitoring sample size adequacy and feasibility, safety with respect to adverse events and 28-day mortality, and efficacy with respect to the primary nosocomial infection/sepsis outcome. The Federal Drug Administration also requested DSMB interim review before opening CRISIS to children below one year of age. The first interim analysis found higher 28-day mortality in one treatment arm. The DSMB maintained trial closure to younger children, and requested a second interim data review six months later. At this second meeting, mortality was no longer of concern, while a weak efficacy trend of lower infection/sepsis rates in one study arm emerged. As over 40% of total patients had been enrolled, the DSMB elected to examine conditional power, and unmask treatment arm identities. Upon finding somewhat greater efficacy in the placebo arm, the DSMB recommended stopping CRISIS due to futility. Conclusions The design and operating procedures of a multicenter randomized trial must consider a pivotal DSMB role. Maximum study design flexibility must be allowed, and investigators must be prepared for protocol modifications due to interim findings. The DSMB must have sufficient clinical and statistical expertise to assess potential importance of interim treatment differences in the setting of multiple looks at accumulating data with numerous outcomes and subgroups. PMID:23392377

46 CFR 153.481 - Stripping quantities and interim standards for Category B NLS tanks on ships built before July 1...

Code of Federal Regulations, 2011 CFR

2011-10-01

... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Design and Equipment for Pollution Control § 153.481 Stripping quantities and interim standards for Category B NLS tanks on... paragraph (b)(1) of this section and does not automatically control the flow rate must have— (i) Manual...

46 CFR 153.481 - Stripping quantities and interim standards for Category B NLS tanks on ships built before July 1...

Code of Federal Regulations, 2012 CFR

2012-10-01

... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Design and Equipment for Pollution Control § 153.481 Stripping quantities and interim standards for Category B NLS tanks on... paragraph (b)(1) of this section and does not automatically control the flow rate must have— (i) Manual...

46 CFR 153.481 - Stripping quantities and interim standards for Category B NLS tanks on ships built before July 1...

Code of Federal Regulations, 2010 CFR

2010-10-01

... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Design and Equipment for Pollution Control § 153.481 Stripping quantities and interim standards for Category B NLS tanks on... paragraph (b)(1) of this section and does not automatically control the flow rate must have— (i) Manual...

46 CFR 153.481 - Stripping quantities and interim standards for Category B NLS tanks on ships built before July 1...

Code of Federal Regulations, 2014 CFR

2014-10-01

... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Design and Equipment for Pollution Control § 153.481 Stripping quantities and interim standards for Category B NLS tanks on... paragraph (b)(1) of this section and does not automatically control the flow rate must have— (i) Manual...

46 CFR 153.481 - Stripping quantities and interim standards for Category B NLS tanks on ships built before July 1...

Code of Federal Regulations, 2013 CFR

2013-10-01

... LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Design and Equipment for Pollution Control § 153.481 Stripping quantities and interim standards for Category B NLS tanks on... paragraph (b)(1) of this section and does not automatically control the flow rate must have— (i) Manual...

The WFIRST Interim Design Reference Mission: Capabilities, Constraints, and Open Questions

NASA Technical Reports Server (NTRS)

Kruk, Jeffrey W.

2012-01-01

The Project Office and Science Definition Team for the Wide-Field Infrared Survey Telescope (WFIRST) are in the midst of a pre-Phase A study to establish a Design Reference Mission (DRM). An Interim report was released in June 2011, with a final report due later in 2012. The predicted performance of the Interim DRM Observatory will be described, including optical quality, observing efficiency, and sensitivity for representative observing scenarios. Observing constraints and other limitations on performance will also be presented, with an emphasis on potential Guest Observer programs. Finally, a brief status update will be provided on open trade studies of interest to the scientific community. The final DRM may differ from the Interim DRM presented here. However, the underlying requirements of the scientific programs are not expected to change, hence the capabilities of the IDRM are likely to be maintained even if the implementation changes in significant ways.

COCHISE Observations of Argon Rydberg Emission from 2 to 16 Micrometers.

DTIC Science & Technology

1983-08-05

8217natu 5 I RNDALL E. M YJOHN S . GARIG Branch Cief Division Director Qualified requestors may obtain additional copies from the Defense Technical... S . TYPE or REPORT a PERIOD COVERED COCHISE OBSERVATIONS OF ARGON Scientific. Interim. RYDBERG EMISSION FROM 2 TO 16 6. PERFORMING 0140. REPORT NUMMER...Comparisons of obd~erved and simulated spectra sliow that s i.ntial ",WIR emission (- 1~gmm Arises from Rydberg states ert~ DO .W-1473 fDITION OF I NOV 65

Comparison of human chorionic somatomammotropin (HCS) standards for radioimmunoassay

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cocola, F.; Genazzani, A.R.; Neri, P.

1973-01-01

A comparison was made between four commercially available HCS standards for radioimmunoassay, an interim standard from the Division of Biological Standards of the Medical Research Council. and a new preparation from our laboratories. Many differences are found between the various HCS preparations tested, and this may be one reason for the discrepancies found in absolute HCS plasma levels reported by different authors. The new Sclavo preparation seems to be the best, and its use is proposed as a new standard for radioimmunoassay. (auth)

Immediate provisionalization with a CAD/CAM interim abutment and crown: a guided soft tissue healing technique.

PubMed

Proussaefs, Periklis

2015-02-01

A technique is described in which a single interim abutment and crown were fabricated in advance and placed the day of dental implant surgery. The contours of the interim crown were identical to the contours of a tentatively designed definitive prosthesis and allowed the tissue to heal and obtain contours that accommodated the contours of the definitive prosthesis. After osseointegration was established, a definitive impression was made with a custom computer-assisted design and computer-assisted manufacturing impression coping. The definitive prosthesis then was fabricated. Copyright © 2015 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

Defensive efficacy interim design: Dynamic benefit/risk ratio view using probability of success.

PubMed

Tang, Zhongwen

2017-01-01

Traditional efficacy interim design is based on alpha spending which does not have intuitive interpretation and hence is difficult to communicate with non-statistician colleagues. The alpha-spending approach is based on efficacy alone and hence does not have the flexibility to incorporate newly emerged safety signal. Newly emerged safety signal may nullify the originally set efficacy boundary. In contrast, the probability of success (POS) concept has intuitive interpretation and hence can facilitate our communication with non-statistician colleagues and help to obtain health authority (HA) buying. The success criteria of POS are not restricted to statistical significance. Hence, POS has the capability to incorporate both efficacy and safety information. We propose to use POS and its credible interval to design efficacy interim. In the proposed method, the efficacy boundary is adjustable to offset newly emerged safety signal.

Report: EPA’s Management of Interim Status Permitting Needs Improvement to Ensure Continued Progress

EPA Pesticide Factsheets

Report #2007-P-00005, December 4, 2006. Interim status is a temporary designation, but some units have existed for as many as 25 years without formal issuance or denial of a permit, or other regulatory controls.

Marine Biochemistry: A New Interdisciplinary Course for the Interim

ERIC Educational Resources Information Center

Goldberg, Arthur S.

1976-01-01

Discusses an undergraduate course which includes lectures, laboratory, and field trips and is designed for the interim winter semester. The course is interdisciplinary, involving a study of the biochemistry, pharmacology, and physiological significance of compounds from marine flora and fauna. (MLH)

Interim Policy to Preserve Separated Personnel’s Electronically Stored Information Subject to Litigation Holds

EPA Pesticide Factsheets

This Interim Policy is designed to ensure the preservation of electronically stored information (ESI), created or received by EPA employees, contractors or grantees with user and email accounts on EPA networks, who have ended their employment with EPA.

Interim Guidelines Growing Longleaf Seedlings in Containers

Treesearch

James P. Barnett; Mark J. Hainds; George A. Hernandez

2002-01-01

These interim guidelines are designed for producers and users of longleaf pine container stock. They are not meant to exclude any container product. The seedling specifications listed in the preferred category are attainable by the grower and will result in excellent field sur vival and early height growth.

An Adaptive Staggered Dose Design for a Normal Endpoint.

PubMed

Wu, Joseph; Menon, Sandeep; Chang, Mark

2015-01-01

In a clinical trial where several doses are compared to a control, a multi-stage design that combines both the selection of the best dose and the confirmation of this selected dose is desirable. An example is the two-stage drop-the-losers or pick-the-winner design, where inferior doses are dropped after interim analysis. Selection of target dose(s) can be based on ranking of observed effects, hypothesis testing with adjustment for multiplicity, or other criteria at interim stages. A number of methods have been proposed and have made significant gains in trial efficiency. However, many of these designs started off with all doses with equal allocation and did not consider prioritizing the doses using existing dose-response information. We propose an adaptive staggered dose procedure that allows explicit prioritization of doses and applies error spending scheme that favors doses with assumed better responses. This design starts off with only a subset of the doses and adaptively adds new doses depending on interim results. Using simulation, we have shown that this design performs better in terms of increased statistical power than the drop-the-losers design given strong prior information of dose response.

A two-stage patient enrichment adaptive design in phase II oncology trials.

PubMed

Song, James X

2014-01-01

Illustrated is the use of a patient enrichment adaptive design in a randomized phase II trial which allows the evaluation of treatment benefits by the biomarker expression level and makes interim adjustment according to the pre-specified rules. The design was applied to an actual phase II metastatic hepatocellular carcinoma (HCC) trial in which progression-free survival (PFS) in two biomarker-defined populations is evaluated at both interim and final analyses. As an extension, a short-term biomarker is used to predict the long-term PFS in a Bayesian model in order to improve the precision of hazard ratio (HR) estimate at the interim analysis. The characteristics of the extended design are examined in a number of scenarios via simulations. The recommended adaptive design is shown to be useful in a phase II setting. When a short-term maker which correlates with the long-term PFS is available, the design can be applied in smaller early phase trials in which PFS requires longer follow-up. In summary, the adaptive design offers flexibility in randomized phase II patient enrichment trials and should be considered in an overall personalized healthcare (PHC) strategy. Copyright © 2013 Elsevier Inc. All rights reserved.

SLS INTERIM CRYOGENIC PROPULSION STAGE TEST ARTICLE ARRIVAL

NASA Image and Video Library

2016-06-19

SLS INTERIM CRYOGENIC PROPULSION STAGE TEST ARTICLE ARRIVES AT WEST DOCK ON SHIELDS ROAD AND IS OFF LOADED FROM BARGEUAH ENGINEERING STUDENT ROBERT HILLAN TALKS TO SPACE STATION CREW MEMBERS ABOUT HIS WINNING 3-D PRINTED TOOL DESIGNED FOR USE ON ISS, AND IS INTERVIEWED BY LOCAL MEDIA

Diversified Satellite Occupations Program. Interim Report.

ERIC Educational Resources Information Center

Call, John Reed

This interim report, covering the period of September 1970 to June 1971, describes a program conducted for elementary, junior high, and senior high grades. The elementary program was designed to help students develop an understanding of occupational competence. The prevention of dropouts and individualizing instruction were concerns of the junior…

Interim Alternative Educational Settings for Children with Disabilities.

ERIC Educational Resources Information Center

Bear, George G.; Quinn, Mary Magee; Burkholder, Susan

This manual is intended to guide school administrators, teachers, school psychologists, and others with the design and implementation of interim alternative education settings (IAES) in compliance with the Individuals with Disabilities Education Act (IDEA) as amended in 1997. Chapter 1 discusses how the IAES evolved as a means of balancing the…

Interim Policy Options for Commercialization of Solar Heating and Cooling Systems.

ERIC Educational Resources Information Center

Bezdek, Roger

This interim report reviews the major incentive policy options available to accelerate market penetration of solar heating and cooling (SHAC) systems. Feasible policy options designed to overcome existing barriers to commercial acceptance and market penetration are identified and evaluated. The report is divided into seven sections, each dealing…

78 FR 48503 - Proposed Revision to Missiles Generated by Extreme Winds

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-08

...-0800, ``Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants: LWR..., ``Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants,'' and Interim Staff Guidance DC... and Hurricane Missiles for Nuclear Power Plants'' (ADAMS, Accession No. ML110940300), and Interim...

The Urban Consumer Education Project. Interim Report, 1979-80.

ERIC Educational Resources Information Center

Marshall, Gail; Haas, Kay

This interim evaluation report of the St. Louis, Missouri Urban Consumer Education Project assesses program effectiveness in terms of teacher training and teacher knowledge of consumer basics, community resource participation, and student and teacher knowledge. The project was designed to teach fifth grade students their rights and…

Grabber arm mechanism for the Italian Research Interim Stage (IRIS)

NASA Technical Reports Server (NTRS)

Turci, Edmondo

1987-01-01

Two deployable arms, named grabbers, were designed and manufactured to provide lateral stability of the perigee spinning stage which will be deployed from the Space Shuttle cargo bay. The spinning stage is supported by a spin table on a cradle at its base. The Italian Research Interim Stage (IRIS) is designed to carry satellites of intermediate mass up to 900 kg. The requirements are defined and the mechanism is described. Functional test results are presented.

Inner Magnetosphere Imager (IMI) solar terrestrial probe class mission preliminary design study report

NASA Technical Reports Server (NTRS)

Hermann, M.; Johnson, L.

1994-01-01

For three decades, magnetospheric field and plasma measurements have been made by diverse instruments flown on spacecraft in many different orbits, widely separated in space and time, and under various solar and magnetospheric conditions. Scientists have used this information to piece together an intricate, yet incomplete view of the magnetosphere. A simultaneous global view, using various light wavelengths and energetic neutral atoms, could reveal exciting new data and help explain complex magnetospheric processes, thus providing us with a clear picture of this region of space. The George C. Marshall Space Flight Center (MSFC) is responsible for defining the IMI mission which will study this region of space. NASA's Space Physics Division of the Office of Space Science placed the IMI third in its queue of Solar Terrestrial Probe missions for launch in the 1990's. A core instrument complement of three images (with the potential addition of one or more mission enhancing instruments) will fly in an elliptical, polar earth orbit with an apogee of 44,600 km and a perigee of 4,800 km. This paper will address the mission objectives, spacecraft design consideration, interim results of the MSFC concept definition study, and future plans.

Modified Interim Mandibular Advancement (MIMA) Appliance for Symptomatic Correction of Obstructive Sleep Apnea

PubMed Central

Singh, Harpreet; Mishra, Harsh Ashok; Gupta, Ankur

2016-01-01

Obstructive Sleep Apnea (OSA) is a chronic, progressive, multifactorial, life-threatening disorder that causes significant impact on patient’s life. Patients with OSA [Apnea/Hypopnea Index (AHI)>30] who cannot tolerate Continuous Positive Airway Pressure (CPAP) therapy or are not surgical candidates may benefit from oral appliances. This paper describes interim appliance devised from existing Hawley’s retainer in patients with OSA. A 38-year-old man of athletic built with history of orthodontic treatment six months back due to esthetic concerns and wearing upper Hawley’s retainer, reported with chief complaint of frequent nocturnal awakening along with excessive daytime somnolence. Based on diagnostic aids, he was diagnosed with Class II Division 1 malocclusion with severe mandibular retrusion. Sleep test revealed AHI score of 34, suggestive of severe OSA. With ENT and Oral surgeon concurrence, mandibular advancement of 7mm with Bilateral Sagital Split Osteotomy (BSSO) with distraction was contemplated as a viable functional and curative stable treatment plan. Because of non-adherence and non-compliance with CPAP therapy and on request of patient, an interim anterior positioning appliance was devised to facilitate comfortable sound sleep till the time surgery is impending. After three months of wearing this customized appliance, improved quality of sleep was discernible; both subjectively as reported by patient and objectively using sleep test (AHI=9.8). PMID:27656589

76 FR 17159 - Office of New Reactors; Final Interim Staff Guidance on Standard Review Plan, Section 17.4...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-28

... Interim Staff Guidance on Standard Review Plan, Section 17.4, ``Reliability Assurance Program'' AGENCY... design reliability assurance program (RAP). This ISG updates the guidance provided to the staff in Standard Review Plan (SRP), Section 17.4, ``Reliability Assurance Program,'' of NUREG-0800, ``Standard...

RESPONSE PROTOCOL TOOLBOX: PLANNING FOR AND RESPONDING TO DRINKING WATER CONTAMINATION THREATS AND INCIDENTS. OVERVIEW AND APPLICATION. INTERIM FINAL - DECEMBER 2003

EPA Science Inventory

The interim final Response Protocol Toolbox: Planning for and Responding to Contamination Threats to Drinking Water Systems is designed to help the water sector effectively and appropriately respond to intentional contamination threats and incidents. It was produced by EPA, buil...

RESPONSE PROTOCOL TOOLBOX: PLANNING FOR AND RESPONDING TO DRINKING WATER CONTAMINATION THREATS AND INCIDENTS. MODULE 4: ANALYTICAL GUIDE. INTERIM FINAL - DECEMBER 2003

EPA Science Inventory

The interim final Response Protocol Toolbox: Planning for and Responding to Contamination Threats to Drinking Water Systems is designed to help the water sector effectively and appropriately respond to intentional contamination threats and incidents. It was produced by EPA, buil...

The role of the Data and Safety Monitoring Board in a clinical trial: the CRISIS study.

PubMed

Holubkov, Richard; Casper, T Charles; Dean, J Michael; Anand, K J S; Zimmerman, Jerry; Meert, Kathleen L; Newth, Christopher J L; Berger, John; Harrison, Rick; Willson, Douglas F; Nicholson, Carol

2013-05-01

Randomized clinical trials are commonly overseen by a Data and Safety Monitoring Board comprised of experts in medicine, ethics, and biostatistics. Data and Safety Monitoring Board responsibilities include protocol approval, interim review of study enrollment, protocol compliance, safety, and efficacy data. Data and Safety Monitoring Board decisions can affect study design and conduct, as well as reported findings. Researchers must incorporate Data and Safety Monitoring Board oversight into the design, monitoring, and reporting of randomized trials. Case study, narrative review. The Data and Safety Monitoring Board's role during the comparative pediatric Critical Illness Stress-Induced Immune Suppression (CRISIS) Prevention Trial is described. The National Institutes of Health-appointed CRISIS Data and Safety Monitoring Board was charged with monitoring sample size adequacy and feasibility, safety with respect to adverse events and 28-day mortality, and efficacy with respect to the primary nosocomial infection/sepsis outcome. The Federal Drug Administration also requested Data and Safety Monitoring Board interim review before opening CRISIS to children below 1 yr of age. The first interim analysis found higher 28-day mortality in one treatment arm. The Data and Safety Monitoring Board maintained trial closure to younger children and requested a second interim data review 6 months later. At this second meeting, mortality was no longer of concern, whereas a weak efficacy trend of lower infection/sepsis rates in one study arm emerged. As over 40% of total patients had been enrolled, the Data and Safety Monitoring Board elected to examine conditional power and unmask treatment arm identities. On finding somewhat greater efficacy in the placebo arm, the Data and Safety Monitoring Board recommended stopping CRISIS due to futility. The design and operating procedures of a multicenter randomized trial must consider a pivotal Data and Safety Monitoring Board role. Maximum study design flexibility must be allowed, and investigators must be prepared for protocol modifications due to interim findings. The Data and Safety Monitoring Board must have sufficient clinical and statistical expertise to assess potential importance of interim treatment differences in the setting of multiple looks at accumulating data with numerous outcomes and subgroups.

Modeling Parenting Programs as an Interim Service for Families Waiting for Children's Mental Health Treatment.

PubMed

Cunningham, Charles E; Rimas, Heather; Chen, Yvonne; Deal, Ken; McGrath, Patrick; Lingley-Pottie, Patricia; Reid, Graham J; Lipman, Ellen; Corkum, Penny

2015-01-01

Using a discrete choice conjoint experiment, we explored the design of parenting programs as an interim strategy for families waiting for children's mental health treatment. Latent class analysis yielded 4 segments with different design preferences. Simulations predicted the Fast-Paced Personal Contact segment, 22.1% of the sample, would prefer weekly therapist-led parenting groups. The Moderate-Paced Personal Contact segment (24.7%) preferred twice-monthly therapist-led parenting groups with twice-monthly lessons. The Moderate-Paced E-Contact segment (36.3%), preferred weekly to twice-monthly contacts, e-mail networking, and a program combining therapist-led sessions with the support of a computerized telephone e-coach. The Slow-Paced E-Contact segment (16.9%) preferred an approach combining monthly therapist-led sessions, e-coaching, and e-mail networking with other parents. Simulations predicted 45.3% of parents would utilize an option combining 5 therapist coaching calls with 5 e-coaching calls, a model that could reduce costs and extend the availability of interim services. Although 41.0% preferred weekly pacing, 58% were predicted to choose an interim parenting service conducted at a twice-monthly to monthly pace. The results of this study suggest that developing interim services reflecting parental preferences requires a choice of formats that includes parenting groups, telephone-coached distance programs, and e-coaching options conducted at a flexible pace.

INTERIM -- Starlink Software Environment

NASA Astrophysics Data System (ADS)

Pearce, Dave; Pavelin, Cliff; Lawden, M. D.

Early versions of this paper were based on a number of other papers produced at a very early stage of the Starlink project. They contained a description of a specific implementation of a subroutine library, speculations on the desirable attributes of a software environment, and future development plans. They reflected the experimental nature of the Starlink software environment at that time. Since then, the situation has changed. The implemented subroutine library, INTERIM_DIR:INTERIM.OLB, is now a well established and widely used piece of software. A completely new Starlink software environment (ADAM) has been developed and distributed. Thus the library released in 1980 as `STARLINK' and now called `INTERIM' has reached the end of its development cycle and is now frozen in its current state, apart from bug corrections. This paper has, therefore, been completely rewritten and restructured to reflect the new situation. Its aim is to describe the facilities of the INTERIM subroutine library as clearly and concisely as possible. It avoids speculation, discussion of design decisions, and announcements of future plans.

A Proposal: The Circular School Year.

ERIC Educational Resources Information Center

Reeves, Robert L.

A proposed plan outlined in this speech divides the school year into three instructional units of 12 weeks each during which time student attendance is required. Three interim units of 15 work days and five vacation days are scheduled in April, August, and December. These interim units are designed to be used by students for remedial work,…

RESPONSE PROTOCOL TOOLBOX: PLANNING FOR AND RESPONDING TO DRINKING WATER CONTAMINATION THREATS AND INCIDENTS. MODULE 1: WATER UTILITIES PLANNING GUIDE - INTERIM FINAL - DECEMBER 2003

EPA Science Inventory

The interim final Response Protocol Toolbox: Planning for and Responding to Contamination Threats to Drinking Water Systems is designed to help the water sector effectively and appropriately respond to intentional contamination threats and incidents. It was produced by EPA, buil...

RESPONSE PROTOCOL TOOLBOX: PLANNING FOR AND RESPONDING TO DRINKING WATER CONTAMINATION THREATS AND INCIDENTS, MODULE 3: SITE CHARACTERIZATION AND SAMPLING GUIDE. INTERIM FINAL - DECEMBER 2003

EPA Science Inventory

The interim final Response Protocol Toolbox: Planning for and Responding to Contamination Threats to Drinking Water Systems is designed to help the water sector effectively and appropriately respond to intentional contamination threats and incidents. It was produced by EPA, buil...

Group sequential designs for stepped-wedge cluster randomised trials

PubMed Central

Grayling, Michael J; Wason, James MS; Mander, Adrian P

2017-01-01

Background/Aims: The stepped-wedge cluster randomised trial design has received substantial attention in recent years. Although various extensions to the original design have been proposed, no guidance is available on the design of stepped-wedge cluster randomised trials with interim analyses. In an individually randomised trial setting, group sequential methods can provide notable efficiency gains and ethical benefits. We address this by discussing how established group sequential methodology can be adapted for stepped-wedge designs. Methods: Utilising the error spending approach to group sequential trial design, we detail the assumptions required for the determination of stepped-wedge cluster randomised trials with interim analyses. We consider early stopping for efficacy, futility, or efficacy and futility. We describe first how this can be done for any specified linear mixed model for data analysis. We then focus on one particular commonly utilised model and, using a recently completed stepped-wedge cluster randomised trial, compare the performance of several designs with interim analyses to the classical stepped-wedge design. Finally, the performance of a quantile substitution procedure for dealing with the case of unknown variance is explored. Results: We demonstrate that the incorporation of early stopping in stepped-wedge cluster randomised trial designs could reduce the expected sample size under the null and alternative hypotheses by up to 31% and 22%, respectively, with no cost to the trial’s type-I and type-II error rates. The use of restricted error maximum likelihood estimation was found to be more important than quantile substitution for controlling the type-I error rate. Conclusion: The addition of interim analyses into stepped-wedge cluster randomised trials could help guard against time-consuming trials conducted on poor performing treatments and also help expedite the implementation of efficacious treatments. In future, trialists should consider incorporating early stopping of some kind into stepped-wedge cluster randomised trials according to the needs of the particular trial. PMID:28653550

Group sequential designs for stepped-wedge cluster randomised trials.

PubMed

Grayling, Michael J; Wason, James Ms; Mander, Adrian P

2017-10-01

The stepped-wedge cluster randomised trial design has received substantial attention in recent years. Although various extensions to the original design have been proposed, no guidance is available on the design of stepped-wedge cluster randomised trials with interim analyses. In an individually randomised trial setting, group sequential methods can provide notable efficiency gains and ethical benefits. We address this by discussing how established group sequential methodology can be adapted for stepped-wedge designs. Utilising the error spending approach to group sequential trial design, we detail the assumptions required for the determination of stepped-wedge cluster randomised trials with interim analyses. We consider early stopping for efficacy, futility, or efficacy and futility. We describe first how this can be done for any specified linear mixed model for data analysis. We then focus on one particular commonly utilised model and, using a recently completed stepped-wedge cluster randomised trial, compare the performance of several designs with interim analyses to the classical stepped-wedge design. Finally, the performance of a quantile substitution procedure for dealing with the case of unknown variance is explored. We demonstrate that the incorporation of early stopping in stepped-wedge cluster randomised trial designs could reduce the expected sample size under the null and alternative hypotheses by up to 31% and 22%, respectively, with no cost to the trial's type-I and type-II error rates. The use of restricted error maximum likelihood estimation was found to be more important than quantile substitution for controlling the type-I error rate. The addition of interim analyses into stepped-wedge cluster randomised trials could help guard against time-consuming trials conducted on poor performing treatments and also help expedite the implementation of efficacious treatments. In future, trialists should consider incorporating early stopping of some kind into stepped-wedge cluster randomised trials according to the needs of the particular trial.

Re-use of pilot data and interim analysis of pivotal data in MRMC studies: a simulation study

NASA Astrophysics Data System (ADS)

Chen, Weijie; Samuelson, Frank; Sahiner, Berkman; Petrick, Nicholas

2017-03-01

Novel medical imaging devices are often evaluated with multi-reader multi-case (MRMC) studies in which radiologists read images of patient cases for a specified clinical task (e.g., cancer detection). A pilot study is often used to measure the effect size and variance parameters that are necessary for sizing a pivotal study (including sizing readers, non-diseased and diseased cases). Due to the practical difficulty of collecting patient cases or recruiting clinical readers, some investigators attempt to include the pilot data as part of their pivotal study. In other situations, some investigators attempt to perform an interim analysis of their pivotal study data based upon which the sample sizes may be re-estimated. Re-use of the pilot data or interim analyses of the pivotal data may inflate the type I error of the pivotal study. In this work, we use the Roe and Metz model to simulate MRMC data under the null hypothesis (i.e., two devices have equal diagnostic performance) and investigate the type I error rate for several practical designs involving re-use of pilot data or interim analysis of pivotal data. Our preliminary simulation results indicate that, under the simulation conditions we investigated, the inflation of type I error is none or only marginal for some design strategies (e.g., re-use of patient data without re-using readers, and size re-estimation without using the effect-size estimated in the interim analysis). Upon further verifications, these are potentially useful design methods in that they may help make a study less burdensome and have a better chance to succeed without substantial loss of the statistical rigor.

Optimal Futility Interim Design: A Predictive Probability of Success Approach with Time-to-Event Endpoint.

PubMed

Tang, Zhongwen

2015-01-01

An analytical way to compute predictive probability of success (PPOS) together with credible interval at interim analysis (IA) is developed for big clinical trials with time-to-event endpoints. The method takes account of the fixed data up to IA, the amount of uncertainty in future data, and uncertainty about parameters. Predictive power is a special type of PPOS. The result is confirmed by simulation. An optimal design is proposed by finding optimal combination of analysis time and futility cutoff based on some PPOS criteria.

Failsafe automation of Phase II clinical trial interim monitoring for stopping rules.

PubMed

Day, Roger S

2010-02-01

In Phase II clinical trials in cancer, preventing the treatment of patients on a study when current data demonstrate that the treatment is insufficiently active or too toxic has obvious benefits, both in protecting patients and in reducing sponsor costs. Considerable efforts have gone into experimental designs for Phase II clinical trials with flexible sample size, usually implemented by early stopping rules. The intended benefits will not ensue, however, if the design is not followed. Despite the best intentions, failures can occur for many reasons. The main goal is to develop an automated system for interim monitoring, as a backup system supplementing the protocol team, to ensure that patients are protected. A secondary goal is to stimulate timely recording of patient assessments. We developed key concepts and performance needs, then designed, implemented, and deployed a software solution embedded in the clinical trials database system. The system has been in place since October 2007. One clinical trial tripped the automated monitor, resulting in e-mails that initiated statistician/investigator review in timely fashion. Several essential contributing activities still require human intervention, institutional policy decisions, and institutional commitment of resources. We believe that implementing the concepts presented here will provide greater assurance that interim monitoring plans are followed and that patients are protected from inadequate response or excessive toxicity. This approach may also facilitate wider acceptance and quicker implementation of new interim monitoring algorithms.

Using phase II data for the analysis of phase III studies: An application in rare diseases.

PubMed

Wandel, Simon; Neuenschwander, Beat; Röver, Christian; Friede, Tim

2017-06-01

Clinical research and drug development in orphan diseases are challenging, since large-scale randomized studies are difficult to conduct. Formally synthesizing the evidence is therefore of great value, yet this is rarely done in the drug-approval process. Phase III designs that make better use of phase II data can facilitate drug development in orphan diseases. A Bayesian meta-analytic approach is used to inform the phase III study with phase II data. It is particularly attractive, since uncertainty of between-trial heterogeneity can be dealt with probabilistically, which is critical if the number of studies is small. Furthermore, it allows quantifying and discounting the phase II data through the predictive distribution relevant for phase III. A phase III design is proposed which uses the phase II data and considers approval based on a phase III interim analysis. The design is illustrated with a non-inferiority case study from a Food and Drug Administration approval in herpetic keratitis (an orphan disease). Design operating characteristics are compared to those of a traditional design, which ignores the phase II data. An analysis of the phase II data reveals good but insufficient evidence for non-inferiority, highlighting the need for a phase III study. For the phase III study supported by phase II data, the interim analysis is based on half of the patients. For this design, the meta-analytic interim results are conclusive and would justify approval. In contrast, based on the phase III data only, interim results are inconclusive and require further evidence. To accelerate drug development for orphan diseases, innovative study designs and appropriate methodology are needed. Taking advantage of randomized phase II data when analyzing phase III studies looks promising because the evidence from phase II supports informed decision-making. The implementation of the Bayesian design is straightforward with public software such as R.

National Home Start Evaluation Interim Report VII. Twenty-Month Program Analysis and Findings.

ERIC Educational Resources Information Center

Love, John M.; And Others

This interim evaluation report focuses on process (formative) and outcome (summative) data collected in spring 1975 on the National Home Start Program. Home Start, a federally-funded 3-year (1972-1975) home-based demonstration program for low-income families with 3- to 5-year-old children was designed to enhance a mother's skills in dealing with…

CCSS Literacy and Math Tools: An Interim Report on Implementation and Sustainability during the Pilot Year

ERIC Educational Resources Information Center

Reumann-Moore, Rebecca; Lawrence, Nancy; Sanders, Felicia; Shaw, Kate; Christman, Jolley Bruce

2011-01-01

This document summarizes the findings from the initial round of research on the development and piloting of two types of instructional tools designed to support teachers' integration of the Common Core State Standards (CCSS) in literacy and math. In this interim report, Research for Action (RFA) presents key findings from the first half of the…

Interim analyses in 2 x 2 crossover trials.

PubMed

Cook, R J

1995-09-01

A method is presented for performing interim analyses in long term 2 x 2 crossover trials with serial patient entry. The analyses are based on a linear statistic that combines data from individuals observed for one treatment period with data from individuals observed for both periods. The coefficients in this linear combination can be chosen quite arbitrarily, but we focus on variance-based weights to maximize power for tests regarding direct treatment effects. The type I error rate of this procedure is controlled by utilizing the joint distribution of the linear statistics over analysis stages. Methods for performing power and sample size calculations are indicated. A two-stage sequential design involving simultaneous patient entry and a single between-period interim analysis is considered in detail. The power and average number of measurements required for this design are compared to those of the usual crossover trial. The results indicate that, while there is minimal loss in power relative to the usual crossover design in the absence of differential carry-over effects, the proposed design can have substantially greater power when differential carry-over effects are present. The two-stage crossover design can also lead to more economical studies in terms of the expected number of measurements required, due to the potential for early stopping. Attention is directed toward normally distributed responses.

Interim Stabilization Equipment Essential and Support Drawing Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

KOCH, M.R.

The purpose of this document is to list the Interim Stabilization equipment drawings that are classified as Essential or Support drawings. Essential Drawings: Those drawings identified by the facility staff as necessary to directly support the safe operation of the facility or equipment. Support Drawings: Those drawings identified by the facility staff that further describe the design details of structures, systems or components shown on essential drawings.

2006 Annual Operations Report for INTEC Operable Unit 3-13, Group 1, Tank Farm Interim Action

DOE Office of Scientific and Technical Information (OSTI.GOV)

D. E. Shanklin

2007-02-14

This annual operations report describes the requirements followed and activities conducted to inspect, monitor, and maintain the items installed during performance of the Waste Area Group 3, Operable Unit 3-13, Group 1, Tank Farm Interim Action, at the Idaho Nuclear Technology and Engineering Center. This report covers the time period from January 1 through December 31, 2006, and describes inspection and monitoring activities for the surface-sealed areas within the tank farm, concrete-lined ditches and culverts in and around the tank farm, the lift station, and the lined evaporation pond. These activities are intended to assure that the interim action ismore » functioning adequately to meet the objectives stated in the Operable Unit 3-13, Record of Decision for the Group 1, Tank Farm Interim Action (DOE/ID-10660) as described in the Group 1 Remedial Design/Remedial Action Work Plan (DOE/ID-10772).« less

Prosthetically guided bone sculpturing for a maxillary complete-arch implant-supported monolithic zirconia fixed prosthesis based on a digital smile design: A clinical report.

PubMed

Rojas-Vizcaya, Fernando

2017-11-01

A digital smile design was used to create an average smile and to develop a removable interim restoration for an edentulous patient with a high smile line and different bone levels in the maxilla. The interim restoration was used as a guide to perform bone sculpturing to create space for the biological width and to restore a monolithic zirconia implant-supported fixed restoration. Copyright © 2017 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

Quantifying the bias in the estimated treatment effect in randomized trials having interim analyses and a rule for early stopping for futility.

PubMed

Walter, S D; Han, H; Briel, M; Guyatt, G H

2017-04-30

In this paper, we consider the potential bias in the estimated treatment effect obtained from clinical trials, the protocols of which include the possibility of interim analyses and an early termination of the study for reasons of futility. In particular, by considering the conditional power at an interim analysis, we derive analytic expressions for various parameters of interest: (i) the underestimation or overestimation of the treatment effect in studies that stop for futility; (ii) the impact of the interim analyses on the estimation of treatment effect in studies that are completed, i.e. that do not stop for futility; (iii) the overall estimation bias in the estimated treatment effect in a single study with such a stopping rule; and (iv) the probability of stopping at an interim analysis. We evaluate these general expressions numerically for typical trial scenarios. Results show that the parameters of interest depend on a number of factors, including the true underlying treatment effect, the difference that the trial is designed to detect, the study power, the number of planned interim analyses and what assumption is made about future data to be observed after an interim analysis. Because the probability of stopping early is small for many practical situations, the overall bias is often small, but a more serious issue is the potential for substantial underestimation of the treatment effect in studies that actually stop for futility. We also consider these ideas using data from an illustrative trial that did stop for futility at an interim analysis. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Experiences with an adaptive design for a dose-finding study in patients with osteoarthritis.

PubMed

Miller, Frank; Björnsson, Marcus; Svensson, Ola; Karlsten, Rolf

2014-03-01

Dose-finding studies in non-oncology areas are usually conducted in Phase II of the development process of a new potential medicine and it is key to choose a good design for such a study, as the results will decide if and how to proceed to Phase III. The present article has focus on the design of a dose-finding study for pain in osteoarthritis patients treated with the TRPV1 antagonist AZD1386. We describe different design alternatives in the planning of this study, the reasoning for choosing the adaptive design and experiences with conduct and interim analysis. Three alternatives were proposed: one single dose-finding study with parallel design, a programme with a smaller Phase IIa study followed by a Phase IIb dose-finding study, and an adaptive dose-finding study. We describe these alternatives in detail and explain why the adaptive design was chosen for the study. We give insights in design aspects of the adaptive study, which need to be pre-planned, like interim decision criteria, statistical analysis method and setup of a Data Monitoring Committee. Based on the interim analysis it was recommended to stop the study for futility since AZD1386 showed no significant pain decrease based on the primary variable. We discuss results and experiences from the conduct of the study with the novel design approach. Huge cost savings have been done compared to if the option with one dose-finding design for Phase II had been chosen. However, we point out several challenges with this approach. Copyright © 2014 Elsevier Inc. All rights reserved.

Soil-cement design study : interim report No. 1.

DOT National Transportation Integrated Search

1971-05-01

Soil-cement base course materials design in Louisiana is based upon durability and compressive strength criteria, with the compressive strength requirements being the controlling factor in 95 percent of the designs. The findings to data have provided...

The role and meaning of interim housing in housing first programs for people experiencing homelessness and mental illness.

PubMed

Zerger, Suzanne; Francombe Pridham, Katherine; Jeyaratnam, Jeyagobi; Connelly, Jolynn; Hwang, Stephen; O'Campo, Patricia; Stergiopoulos, Vicky

2014-07-01

The housing first (HF) model for individuals experiencing homelessness and mental illness differs by design from traditional models that require consumers to achieve "housing readiness" by meeting program or treatment prerequisites in transitional housing settings prior to permanent housing placement. Given a growing body of evidence for its favorable outcomes and cost effectiveness, HF is increasingly seen as an alternative to and argument against these traditional programs. As such, it is important that the elements and implementation challenges of the HF model be clearly understood and articulated. This qualitative study explored a largely unexamined aspect of the HF model-the need for and meaning of temporary residential settings (interim housing), a place to stay while waiting to secure permanent housing-using interviews and focus groups with service providers and consumers who experienced interim housing during implementation of HF in a large urban center. Although interim housing may not be necessary for all programs implementing the model, our study revealed numerous reasons and demands for safe, flexible interim housing options, and illustrated how they influence the effectiveness of consumer recovery, continuous service engagement, and housing stability.

Adaptive design clinical trials: a review of the literature and ClinicalTrials.gov

PubMed Central

Bothwell, Laura E; Avorn, Jerry; Khan, Nazleen F; Kesselheim, Aaron S

2018-01-01

Objectives This review investigates characteristics of implemented adaptive design clinical trials and provides examples of regulatory experience with such trials. Design Review of adaptive design clinical trials in EMBASE, PubMed, Cochrane Registry of Controlled Clinical Trials, Web of Science and ClinicalTrials.gov. Phase I and seamless Phase I/II trials were excluded. Variables extracted from trials included basic study characteristics, adaptive design features, size and use of independent data monitoring committees (DMCs) and blinded interim analyses. We also examined use of the adaptive trials in new drug submissions to the Food and Drug Administration (FDA) and European Medicines Agency (EMA) and recorded regulators’ experiences with adaptive designs. Results 142 studies met inclusion criteria. There has been a recent growth in publicly reported use of adaptive designs among researchers around the world. The most frequently appearing types of adaptations were seamless Phase II/III (57%), group sequential (21%), biomarker adaptive (20%), and adaptive dose-finding designs (16%). About one-third (32%) of trials reported an independent DMC, while 6% reported blinded interim analysis. We found that 9% of adaptive trials were used for FDA product approval consideration, and 12% were used for EMA product approval consideration. International regulators had mixed experiences with adaptive trials. Many product applications with adaptive trials had extensive correspondence between drug sponsors and regulators regarding the adaptive designs, in some cases with regulators requiring revisions or alterations to research designs. Conclusions Wider use of adaptive designs will necessitate new drug application sponsors to engage with regulatory scientists during planning and conduct of the trials. Investigators need to more consistently report protections intended to preserve confidentiality and minimise potential operational bias during interim analysis. PMID:29440155

Exploring the statistical and clinical impact of two interim analyses on the Phase II design with option for direct assignment.

PubMed

An, Ming-Wen; Mandrekar, Sumithra J; Edelman, Martin J; Sargent, Daniel J

2014-07-01

The primary goal of Phase II clinical trials is to understand better a treatment's safety and efficacy to inform a Phase III go/no-go decision. Many Phase II designs have been proposed, incorporating randomization, interim analyses, adaptation, and patient selection. The Phase II design with an option for direct assignment (i.e. stop randomization and assign all patients to the experimental arm based on a single interim analysis (IA) at 50% accrual) was recently proposed [An et al., 2012]. We discuss this design in the context of existing designs, and extend it from a single-IA to a two-IA design. We compared the statistical properties and clinical relevance of the direct assignment design with two IA (DAD-2) versus a balanced randomized design with two IA (BRD-2) and a direct assignment design with one IA (DAD-1), over a range of response rate ratios (2.0-3.0). The DAD-2 has minimal loss in power (<2.2%) and minimal increase in T1ER (<1.6%) compared to a BRD-2. As many as 80% more patients were treated with experimental vs. control in the DAD-2 than with the BRD-2 (experimental vs. control ratio: 1.8 vs. 1.0), and as many as 64% more in the DAD-2 than with the DAD-1 (1.8 vs. 1.1). We illustrate the DAD-2 using a case study in lung cancer. In the spectrum of Phase II designs, the direct assignment design, especially with two IA, provides a middle ground with desirable statistical properties and likely appeal to both clinicians and patients. Copyright © 2014 Elsevier Inc. All rights reserved.

Railroad classification yard design methodology study Elkhart Yard Rehabilitation : a case study

DOT National Transportation Integrated Search

1980-02-01

This interim report documents the application of a railroad classification : yard design methodology to CONRAIL's Elkhart Yard Rehabilitation. This : case study effort represents Phase 2 of a larger effort to develop a yard : design methodology, and ...

Interim analysis: A rational approach of decision making in clinical trial.

PubMed

Kumar, Amal; Chakraborty, Bhaswat S

2016-01-01

Interim analysis of especially sizeable trials keeps the decision process free of conflict of interest while considering cost, resources, and meaningfulness of the project. Whenever necessary, such interim analysis can also call for potential termination or appropriate modification in sample size, study design, and even an early declaration of success. Given the extraordinary size and complexity today, this rational approach helps to analyze and predict the outcomes of a clinical trial that incorporate what is learned during the course of a study or a clinical development program. Such approach can also fill the gap by directing the resources toward relevant and optimized clinical trials between unmet medical needs and interventions being tested currently rather than fulfilling only business and profit goals.

The role of interim 18F-FDG PET/CT in prediction of response to ipilimumab treatment in metastatic melanoma.

PubMed

Sachpekidis, Christos; Anwar, Hoda; Winkler, Julia; Kopp-Schneider, Annette; Larribere, Lionel; Haberkorn, Uwe; Hassel, Jessica C; Dimitrakopoulou-Strauss, Antonia

2018-07-01

The aim of the present study was to assess the value of interim 18 F-FDG PET/CT performed after the first two cycles of ipilimumab treatment in the prediction of the final clinical response to this type of immunotherapy. The study group comprised 41 patients with unresectable metastatic melanoma scheduled for ipilimumab therapy. Whole-body 18 F-FDG PET/CT was performed before the start of ipilimumab treatment (baseline PET/CT) and after the initial two cycles of ipilimumab treatment (interim PET/CT). Evaluation of patient response to treatment was based on the European Organization for Research and Treatment of Cancer (EORTC) 1999 criteria for PET as well as the recently proposed PET Response Evaluation Criteria for Immunotherapy (PERCIMT). The patients' best clinical response, assessed at a median of 21.4 months (range 6.3-41.9 months) was used as reference. According to their best clinical response, the patients were divided into two groups: those showing clinical benefit (CB) including stable disease, partial response and complete response (31 patients), and those showing no clinical benefit (no-CB including progressive disease (10 patients). According to the EORTC criteria, interim PET/CT demonstrated progressive metabolic disease (PMD) in 20 patients, stable metabolic disease (SMD) in 11 patients, partial metabolic response (PMR) in 8 patients, and complete metabolic response (CMR) in 2 patients. According to the PERCIMT, interim PET/CT demonstrated PMD in 9 patients, SMD in 24 patients, PMR in 6 patients and CMR in 2 patients. On the basis of the interim PET, the patients were divided in a similar manner to the division according to clinical response into those showing metabolic benefit (MB) including SMD, PMR and CMR, and those showing no metabolic benefit (no-MB) including PMD. According to this dichotomization, the EORTC criteria showed a sensitivity (correctly predicting CB) of 64.5%, a specificity (correctly predicting no-CB) of 90.0%, a positive predictive value (PPV) of 95.2%, a negative predictive value (NPV) of 45.0% and an accuracy of 70.7% in predicting best clinical response. The PERCIMT showed a sensitivity of 93.6%, a specificity of 70.0%, a PPV of 90.6%, a NPV of 77.8% and an accuracy of 87.8%. The McNemar test showed that the PERCIMT had a significantly higher sensitivity than EORTC criteria (p = 0.004), while there was no significant difference in specificity (p = 0.5). The agreement between the two sets of criteria was poor (McNemar test p = 0.001, and accordingly kappa = 0.46). The application of the recently proposed PERCIMT to interim 18 F-FDG PET/CT provides a more sensitive predictor of final clinical response to immunotherapy than the application of the EORTC criteria in patients with metastatic melanoma.

75 FR 54527 - Defense Federal Acquisition Regulation Supplement; Government Rights in the Design of DoD Vessels...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-08

... Defense Authorization Act for Fiscal Year 2009 and the Vessel Hull Design Protection Amendments of 2008...) and the Vessel Hull Design Protection Amendments of 2008 (Pub. L. 110-434). DoD published the interim...

Railroad classification yard design methodology study : East Deerfield Yard, a case study

DOT National Transportation Integrated Search

1980-02-01

This interim report documents the application of a railroad classification yard design methodology to Boston and Maine's East Deerfield Yard Rehabiliation. This case study effort represents Phase 2 of a larger effort to develop a yard design methodol...

77 FR 65855 - Cancellation of Indianapolis Grain Inspection & Weighing Service, Inc. Designation; Selection of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-31

... DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration Cancellation of Indianapolis Grain Inspection & Weighing Service, Inc. Designation; Selection of Interim Provider; Opportunity for Designation in the Indianapolis, IN Area AGENCY: Grain Inspection, Packers and Stockyards...

Conditional estimation using prior information in 2-stage group sequential designs assuming asymptotic normality when the trial terminated early.

PubMed

Shimura, Masashi; Maruo, Kazushi; Gosho, Masahiko

2018-04-23

Two-stage designs are widely used to determine whether a clinical trial should be terminated early. In such trials, a maximum likelihood estimate is often adopted to describe the difference in efficacy between the experimental and reference treatments; however, this method is known to display conditional bias. To reduce such bias, a conditional mean-adjusted estimator (CMAE) has been proposed, although the remaining bias may be nonnegligible when a trial is stopped for efficacy at the interim analysis. We propose a new estimator for adjusting the conditional bias of the treatment effect by extending the idea of the CMAE. This estimator is calculated by weighting the maximum likelihood estimate obtained at the interim analysis and the effect size prespecified when calculating the sample size. We evaluate the performance of the proposed estimator through analytical and simulation studies in various settings in which a trial is stopped for efficacy or futility at the interim analysis. We find that the conditional bias of the proposed estimator is smaller than that of the CMAE when the information time at the interim analysis is small. In addition, the mean-squared error of the proposed estimator is also smaller than that of the CMAE. In conclusion, we recommend the use of the proposed estimator for trials that are terminated early for efficacy or futility. Copyright © 2018 John Wiley & Sons, Ltd.

Tolerable movement criteria for highway bridges, volume I : interim report.

DOT National Transportation Integrated Search

1982-09-01

"The design procedure presented considers both strength and serviceability criteria. The procedure involves designing a bridge assuming no settlement will take place, using the American Association of State Highway and Transportation Officials workin...

77 FR 66578 - Cancellation of Indianapolis Grain Inspection & Weighing Service, Inc. Designation; Selection of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-06

... Indianapolis Grain Inspection & Weighing Service, Inc. Designation; Selection of Interim Provider; Opportunity for Designation in the Indianapolis, IN Area; Correction AGENCY: Grain Inspection, Packers and Stockyards Administration, USDA. ACTION: Notice; correction. SUMMARY: The USDA, Grain Inspection, Packers and...

Final Alternatives Assessment of Interim Response Actions for Other Contamination Sources M-1 Settling Basins, Rocky Mountain Arsenal, Version 3.1

DTIC Science & Technology

1989-11-01

u = W. QU- -; t2 E~ zi=- 6e-1 wo u CC .2 211 ~ .CC > . I- - . Ece Zc a- c’ cC I C! 0. - ZEC E ~C C 6-12 E 0 U- .0 E ~E 0 -6 -1 1 I- 8t~ V- .~ u osz w18...Materials and Waste Management Division Colorado Department of Health 4210 East 11th Avenue Denver, CO 80020 Victoria Peters , Esq. Office of Attorney...999 18th Street, Suite 500 Denver, CO 80202-2405 Dr. Peter Gober U.S. Fish and Wildlife Service Rocky Mountain Arsenal, Bldg. 111 Commerce City, CO

Interim Service ISDN Satellite (ISIS) simulator development for advanced satellite designs and experiments

NASA Technical Reports Server (NTRS)

Pepin, Gerard R.

1992-01-01

The simulation development associated with the network models of both the Interim Service Integrated Services Digital Network (ISDN) Satellite (ISIS) and the Full Service ISDN Satellite (FSIS) architectures is documented. The ISIS Network Model design represents satellite systems like the Advanced Communications Technology Satellite (ACTS) orbiting switch. The FSIS architecture, the ultimate aim of this element of the Satellite Communications Applications Research (SCAR) Program, moves all control and switching functions on-board the next generation ISDN communications satellite. The technical and operational parameters for the advanced ISDN communications satellite design will be obtained from the simulation of ISIS and FSIS engineering software models for their major subsystems. Discrete event simulation experiments will be performed with these models using various traffic scenarios, design parameters, and operational procedures. The data from these simulations will be used to determine the engineering parameters for the advanced ISDN communications satellite.

A Procedure for Structural Weight Estimation of Single Stage to Orbit Launch Vehicles (Interim User's Manual)

NASA Technical Reports Server (NTRS)

Martinovic, Zoran N.; Cerro, Jeffrey A.

2002-01-01

This is an interim user's manual for current procedures used in the Vehicle Analysis Branch at NASA Langley Research Center, Hampton, Virginia, for launch vehicle structural subsystem weight estimation based on finite element modeling and structural analysis. The process is intended to complement traditional methods of conceptual and early preliminary structural design such as the application of empirical weight estimation or application of classical engineering design equations and criteria on one dimensional "line" models. Functions of two commercially available software codes are coupled together. Vehicle modeling and analysis are done using SDRC/I-DEAS, and structural sizing is performed with the Collier Research Corp. HyperSizer program.

Final closure plan for the high-explosives open burn treatment facility at Lawrence Livermore National Laboratory Experimental Test Site 300

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mathews, S.

This document addresses the interim status closure of the HE Open Bum Treatment Facility, as detailed by Title 22, Division 4.5, Chapter 15, Article 7 of the Califonia Code of Regulations (CCR) and by Title 40, Code of Federal Regulations (CFR) Part 265, Subpart G, ``Closure and Post Closure.`` The Closure Plan (Chapter 1) and the Post- Closure Plan (Chapter 2) address the concept of long-term hazard elimination. The Closure Plan provides for capping and grading the HE Open Bum Treatment Facility and revegetating the immediate area in accordance with applicable requirements. The Closure Plan also reflects careful consideration ofmore » site location and topography, geologic and hydrologic factors, climate, cover characteristics, type and amount of wastes, and the potential for contaminant migration. The Post-Closure Plan is designed to allow LLNL to monitor the movement, if any, of pollutants from the treatment area. In addition, quarterly inspections will ensure that all surfaces of the closed facility, including the cover and diversion ditches, remain in good repair, thus precluding the potential for contaminant migration.« less

Statistical aspects of the TNK-S2B trial of tenecteplase versus alteplase in acute ischemic stroke: an efficient, dose-adaptive, seamless phase II/III design.

PubMed

Levin, Bruce; Thompson, John L P; Chakraborty, Bibhas; Levy, Gilberto; MacArthur, Robert; Haley, E Clarke

2011-08-01

TNK-S2B, an innovative, randomized, seamless phase II/III trial of tenecteplase versus rt-PA for acute ischemic stroke, terminated for slow enrollment before regulatory approval of use of phase II patients in phase III. (1) To review the trial design and comprehensive type I error rate simulations and (2) to discuss issues raised during regulatory review, to facilitate future approval of similar designs. In phase II, an early (24-h) outcome and adaptive sequential procedure selected one of three tenecteplase doses for phase III comparison with rt-PA. Decision rules comparing this dose to rt-PA would cause stopping for futility at phase II end, or continuation to phase III. Phase III incorporated two co-primary hypotheses, allowing for a treatment effect at either end of the trichotomized Rankin scale. Assuming no early termination, four interim analyses and one final analysis of 1908 patients provided an experiment-wise type I error rate of <0.05. Over 1,000 distribution scenarios, each involving 40,000 replications, the maximum type I error in phase III was 0.038. Inflation from the dose selection was more than offset by the one-half continuity correction in the test statistics. Inflation from repeated interim analyses was more than offset by the reduction from the clinical stopping rules for futility at the first interim analysis. Design complexity and evolving regulatory requirements lengthened the review process. (1) The design was innovative and efficient. Per protocol, type I error was well controlled for the co-primary phase III hypothesis tests, and experiment-wise. (2a) Time must be allowed for communications with regulatory reviewers from first design stages. (2b) Adequate type I error control must be demonstrated. (2c) Greater clarity is needed on (i) whether this includes demonstration of type I error control if the protocol is violated and (ii) whether simulations of type I error control are acceptable. (2d) Regulatory agency concerns that protocols for futility stopping may not be followed may be allayed by submitting interim analysis results to them as these analyses occur.

The development of an interim generalized gate logic software simulator

NASA Technical Reports Server (NTRS)

Mcgough, J. G.; Nemeroff, S.

1985-01-01

A proof-of-concept computer program called IGGLOSS (Interim Generalized Gate Logic Software Simulator) was developed and is discussed. The simulator engine was designed to perform stochastic estimation of self test coverage (fault-detection latency times) of digital computers or systems. A major attribute of the IGGLOSS is its high-speed simulation: 9.5 x 1,000,000 gates/cpu sec for nonfaulted circuits and 4.4 x 1,000,000 gates/cpu sec for faulted circuits on a VAX 11/780 host computer.

In vitro evaluation of the marginal integrity of CAD/CAM interim crowns.

PubMed

Kelvin Khng, Kwang Yong; Ettinger, Ronald L; Armstrong, Steven R; Lindquist, Terry; Gratton, David G; Qian, Fang

2016-05-01

The accuracy of interim crowns made with computer-aided design and computer-aided manufacturing (CAD/CAM) systems has not been well investigated. The purpose of this in vitro study was to evaluate the marginal integrity of interim crowns made by CAD/CAM compared with that of conventional polymethylmethacrylate (PMMA) crowns. A dentoform mandibular left second premolar was prepared for a ceramic crown and scanned for the fabrication of 60 stereolithical resin dies, half of which were scanned to fabricate 15 Telio CAD-CEREC and 15 Paradigm MZ100-E4D-E4D crowns. Fifteen Caulk and 15 Jet interim crowns were made on the remaining resin dies. All crowns were cemented with Tempgrip under a 17.8-N load, thermocycled for 1000 cycles, placed in 0.5% acid fuschin for 24 hours, and embedded in epoxy resin before sectioning from the mid-buccal to mid-lingual surface. The marginal discrepancy was measured using a traveling microscope, and dye penetration was measured as a percentage of the overall length under the crown. The mean vertical marginal discrepancy of the conventionally made interim crowns was greater than for the CAD/CAM crowns (P=.006), while no difference was found for the horizontal component (P=.276). The mean vertical marginal discrepancy at the facial surface of the Caulk crowns was significantly greater than that of the other 3 types of interim crowns (P<.001). At the facial margin, the mean horizontal component of the Telio crowns was significantly larger than that of the other 3 types, with no difference at the lingual margins (P=.150). The mean percentage dye penetration for the Paradigm MZ100-E4D crowns was significantly greater and for Jet crowns significantly smaller than for the other 3 crowns (P<.001). However, the mean percentage dye penetration was significantly correlated with the vertical and horizontal marginal discrepancies of the Jet interim crowns at the facial surface and with the horizontal marginal discrepancies of the Caulk interim crowns at the lingual surface (P<.01 in each instance). A significantly smaller vertical marginal discrepancy was found with the interim crowns fabricated by CAD/CAM as compared with PMMA crowns; however, this difference was not observed for the horizontal component. The percentage dye penetration was correlated with vertical and horizontal discrepancies at the facial surface for the Jet interim crowns and with horizontal discrepancies at the lingual surface for the Caulk interim crowns. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

Locomotive cab design development. volume III: design application analysis - Interim report

DOT National Transportation Integrated Search

1976-10-01

In Volume II of this service of reports on Locomotive Cab Design Development, changes were recommended in the layout and equipment content of locomotive cabs. This report studies the impact of these changes on the interface of the cab with the rest o...

Adaptive graph-based multiple testing procedures

PubMed Central

Klinglmueller, Florian; Posch, Martin; Koenig, Franz

2016-01-01

Multiple testing procedures defined by directed, weighted graphs have recently been proposed as an intuitive visual tool for constructing multiple testing strategies that reflect the often complex contextual relations between hypotheses in clinical trials. Many well-known sequentially rejective tests, such as (parallel) gatekeeping tests or hierarchical testing procedures are special cases of the graph based tests. We generalize these graph-based multiple testing procedures to adaptive trial designs with an interim analysis. These designs permit mid-trial design modifications based on unblinded interim data as well as external information, while providing strong family wise error rate control. To maintain the familywise error rate, it is not required to prespecify the adaption rule in detail. Because the adaptive test does not require knowledge of the multivariate distribution of test statistics, it is applicable in a wide range of scenarios including trials with multiple treatment comparisons, endpoints or subgroups, or combinations thereof. Examples of adaptations are dropping of treatment arms, selection of subpopulations, and sample size reassessment. If, in the interim analysis, it is decided to continue the trial as planned, the adaptive test reduces to the originally planned multiple testing procedure. Only if adaptations are actually implemented, an adjusted test needs to be applied. The procedure is illustrated with a case study and its operating characteristics are investigated by simulations. PMID:25319733

The use of group sequential, information-based sample size re-estimation in the design of the PRIMO study of chronic kidney disease.

PubMed

Pritchett, Yili; Jemiai, Yannis; Chang, Yuchiao; Bhan, Ishir; Agarwal, Rajiv; Zoccali, Carmine; Wanner, Christoph; Lloyd-Jones, Donald; Cannata-Andía, Jorge B; Thompson, Taylor; Appelbaum, Evan; Audhya, Paul; Andress, Dennis; Zhang, Wuyan; Solomon, Scott; Manning, Warren J; Thadhani, Ravi

2011-04-01

Chronic kidney disease is associated with a marked increase in risk for left ventricular hypertrophy and cardiovascular mortality compared with the general population. Therapy with vitamin D receptor activators has been linked with reduced mortality in chronic kidney disease and an improvement in left ventricular hypertrophy in animal studies. PRIMO (Paricalcitol capsules benefits in Renal failure Induced cardia MOrbidity) is a multinational, multicenter randomized controlled trial to assess the effects of paricalcitol (a selective vitamin D receptor activator) on mild to moderate left ventricular hypertrophy in patients with chronic kidney disease. Subjects with mild-moderate chronic kidney disease are randomized to paricalcitol or placebo after confirming left ventricular hypertrophy using a cardiac echocardiogram. Cardiac magnetic resonance imaging is then used to assess left ventricular mass index at baseline, 24 and 48 weeks, which is the primary efficacy endpoint of the study. Because of limited prior data to estimate sample size, a maximum information group sequential design with sample size re-estimation is implemented to allow sample size adjustment based on the nuisance parameter estimated using the interim data. An interim efficacy analysis is planned at a pre-specified time point conditioned on the status of enrollment. The decision to increase sample size depends on the observed treatment effect. A repeated measures analysis model, using available data at Week 24 and 48 with a backup model of an ANCOVA analyzing change from baseline to the final nonmissing observation, are pre-specified to evaluate the treatment effect. Gamma-family of spending function is employed to control family-wise Type I error rate as stopping for success is planned in the interim efficacy analysis. If enrollment is slower than anticipated, the smaller sample size used in the interim efficacy analysis and the greater percent of missing week 48 data might decrease the parameter estimation accuracy, either for the nuisance parameter or for the treatment effect, which might in turn affect the interim decision-making. The application of combining a group sequential design with a sample-size re-estimation in clinical trial design has the potential to improve efficiency and to increase the probability of trial success while ensuring integrity of the study.

Implementation of the AASHTO mechanistic-empirical pavement design guide for Colorado.

DOT National Transportation Integrated Search

2000-01-01

The objective of this project was to integrate the American Association of State Highway and Transportation Officials (AASHTO) Mechanistic-Empirical Pavement Design Guide, Interim Edition: A Manual of Practice and its accompanying software into the d...

Calibration of the MEPDG transfer functions in Georgia : task order 2 report.

DOT National Transportation Integrated Search

2015-03-28

The Georgia Department of Transportation (GDOT) currently uses the empirical 1972 AASHTO Interim Guide for : Design of Pavement Structures as their standard pavement design procedure. However, GDOT plans to transition to the : Mechanistic Empirical P...

Evolution of the Division of Labor between Genes and Enzymes in the RNA World

PubMed Central

Boza, Gergely; Szilágyi, András; Kun, Ádám; Santos, Mauro; Szathmáry, Eörs

2014-01-01

The RNA world is a very likely interim stage of the evolution after the first replicators and before the advent of the genetic code and translated proteins. Ribozymes are known to be able to catalyze many reaction types, including cofactor-aided metabolic transformations. In a metabolically complex RNA world, early division of labor between genes and enzymes could have evolved, where the ribozymes would have been transcribed from the genes more often than the other way round, benefiting the encapsulating cells through this dosage effect. Here we show, by computer simulations of protocells harboring unlinked RNA replicators, that the origin of replicational asymmetry producing more ribozymes from a gene template than gene strands from a ribozyme template is feasible and robust. Enzymatic activities of the two modeled ribozymes are in trade-off with their replication rates, and the relative replication rates compared to those of complementary strands are evolvable traits of the ribozymes. The degree of trade-off is shown to have the strongest effect in favor of the division of labor. Although some asymmetry between gene and enzymatic strands could have evolved even in earlier, surface-bound systems, the shown mechanism in protocells seems inevitable and under strong positive selection. This could have preadapted the genetic system for transcription after the subsequent origin of chromosomes and DNA. PMID:25474573

Evolution of the division of labor between genes and enzymes in the RNA world.

PubMed

Boza, Gergely; Szilágyi, András; Kun, Ádám; Santos, Mauro; Szathmáry, Eörs

2014-12-01

The RNA world is a very likely interim stage of the evolution after the first replicators and before the advent of the genetic code and translated proteins. Ribozymes are known to be able to catalyze many reaction types, including cofactor-aided metabolic transformations. In a metabolically complex RNA world, early division of labor between genes and enzymes could have evolved, where the ribozymes would have been transcribed from the genes more often than the other way round, benefiting the encapsulating cells through this dosage effect. Here we show, by computer simulations of protocells harboring unlinked RNA replicators, that the origin of replicational asymmetry producing more ribozymes from a gene template than gene strands from a ribozyme template is feasible and robust. Enzymatic activities of the two modeled ribozymes are in trade-off with their replication rates, and the relative replication rates compared to those of complementary strands are evolvable traits of the ribozymes. The degree of trade-off is shown to have the strongest effect in favor of the division of labor. Although some asymmetry between gene and enzymatic strands could have evolved even in earlier, surface-bound systems, the shown mechanism in protocells seems inevitable and under strong positive selection. This could have preadapted the genetic system for transcription after the subsequent origin of chromosomes and DNA.

78 FR 25734 - Notice of Petition for Waiver of Hussmann From the Department of Energy Commercial Refrigerator...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-02

... to provide materially inaccurate comparative data.'' The design characteristics constituting the... inaccurate comparative data'' The design characteristics constituting the grounds for the Interim Waiver... Secretary) to prescribe test procedures that are reasonably designed to produce results that measure energy...

77 FR 64564 - Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-22

...-Basis Hurricane and Hurricane Missiles AGENCY: Nuclear Regulatory Commission. ACTION: Proposed interim...-ISG-024, ``Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles....221, ``Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants.'' DATES: Submit...

75 FR 21695 - Interim Notice of Funding Availability for the Department of Transportation's National...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-26

... district plans, and other strategies, including land acquisition, designed to create walkable, mixed-use... million of the available TIGER II funds for the planning, preparation, or design of Eligible Projects... manner that will be sustainable for generations to come. Therefore, for projects designed to enhance...

Predictive design procedures, VESYS users manual : an interim design method for flexible pavements using the VESYS structural subsystem

DOT National Transportation Integrated Search

1978-01-01

This manual has been written to provide the pavement manager and design engineer with a ready reference of procedures to predict the structural responses and hence the integrity of flexible pavements. A pavement section of known geometry is chosen, a...

Evaluation of internal fit of interim crown fabricated with CAD/CAM milling and 3D printing system.

PubMed

Lee, Wan-Sun; Lee, Du-Hyeong; Lee, Kyu-Bok

2017-08-01

This study is to evaluate the internal fit of the crown manufactured by CAD/CAM milling method and 3D printing method. The master model was fabricated with stainless steel by using CNC machine and the work model was created from the vinyl-polysiloxane impression. After scanning the working model, the design software is used to design the crown. The saved STL file is used on the CAD/CAM milling method and two types of 3D printing method to produce 10 interim crowns per group. Internal discrepancy measurement uses the silicon replica method and the measured data are analyzed with One-way ANOVA to verify the statistic significance. The discrepancy means (standard deviation) of the 3 groups are 171.6 (97.4) µm for the crown manufactured by the milling system and 149.1 (65.9) and 91.1 (36.4) µm, respectively, for the crowns manufactured with the two types of 3D printing system. There was a statistically significant difference and the 3D printing system group showed more outstanding value than the milling system group. The marginal and internal fit of the interim restoration has more outstanding 3D printing method than the CAD/CAM milling method. Therefore, the 3D printing method is considered as applicable for not only the interim restoration production, but also in the dental prosthesis production with a higher level of completion.

Asphaltic concrete overlays of rigid and flexible pavements : interim report No. 1.

DOT National Transportation Integrated Search

1977-09-01

This study evaluated the effect of a given thickness of asphaltic concrete overlay in rehabilitating 53 test sections conforming to the experiment design. This factorial design specified various levels of traffic intensity and overlay thickness for b...

Federal Employees Health Benefits Program and Federal Employees Dental and Vision Insurance Program: eligibility for Pathway Programs participants. Interim final rule with request for comments.

PubMed

2014-01-06

The U.S. Office of Personnel Management (OPM) is issuing an interim final regulation to update the Federal Employees Health Benefits Program (FEHBP) and the Federal Employees Dental and Vision Insurance Program (FEDVIP) regulations to reflect updated election opportunities for participants in the Pathways Programs. The Pathways Programs were created by Executive Order (E.O.) 13562, signed by the President on December 27, 2010, and are designed to enable the Federal Government to compete effectively for students and recent graduates by improving its recruitment efforts through internships and similar programs with Federal agencies. This interim final rule furthers these recruitment and retention efforts by providing health insurance, as well as dental and vision benefits, to eligible program participants and their families.

Precise Reproduction of Soft Tissue Structure around the Pontic Area Using Computer-Aided Design and Manufacturing.

PubMed

Lee, Hyeonjong; Paek, Janghyun; Noh, Kwantae; Kwon, Kung-Rock

2017-08-21

Reproducing soft tissue contours around a pontic area is important for the fabrication of an esthetic prosthesis, especially in the anterior area. A gingival model that precisely replicates the soft tissue structure around the pontic area can be easily obtained by taking a pick-up impression of an interim fixed dental prosthesis. After a working cast is fabricated using the customary technique, the pick-up model is superimposed onto the working model for the pontic area using computer-aided design and manufacturing (CAD/CAM). A definitive restoration using this technique would be well adapted to the pontic base, which is formed by the interim prosthesis. © 2017 by the American College of Prosthodontists.

76 FR 63640 - Public Housing Assessment System (PHAS): Proposed Physical Condition Interim Scoring Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-13

... call-for-aid is a system designed to provide elderly residents the opportunity to call for help in the... open. This bars that are change also rewrites designed to open the Level 3 should open. If they...

Nutrient Control Design Manual–State of the Technology Review Report

EPA Science Inventory

This EPA document is an interim product in the development of revised design guidance for nitrogen and phosphorus control at municipal WWTPs. This document presents findings from an extensive review of nitrogen and phosphorus control technologies and techniques currently applied...

Locomotive cab design development. volume 2 : operator's manual - Interim Report

DOT National Transportation Integrated Search

1976-10-01

Locomotive Cab 913 designed as a result of Contract DOT-TSC- 913 has been built as a hard mock-up. This Operator's Manual is to familiarize the user with the mock-up. Normal and emergency procedures and cab facilities are described.

Characterization of the radiation environment for a large-area interim spent-nuclear-fuel storage facility

NASA Astrophysics Data System (ADS)

Fortkamp, Jonathan C.

Current needs in the nuclear industry and movements in the political arena indicate that authorization may soon be given for development of a federal interim storage facility for spent nuclear fuel. The initial stages of the design work have already begun within the Department of Energy and are being reviewed by the Nuclear Regulatory Commission. This dissertation addresses the radiation environment around an interim spent nuclear fuel storage facility. Specifically the dissertation characterizes the radiation dose rates around the facility based on a design basis source term, evaluates the changes in dose due to varying cask spacing configurations, and uses these results to define some applicable health physics principles for the storage facility. Results indicate that dose rates from the facility are due primarily from photons from the spent fuel and Co-60 activation in the fuel assemblies. In the modeled cask system, skyshine was a significant contribution to dose rates at distances from the cask array, but this contribution can be reduced with an alternate cask venting system. With the application of appropriate health physics principles, occupation doses can be easily maintained far below regulatory limits and maintained ALARA.

Ecological Risk Assessment Guidance for Superfund: Process for Designing and Conducting Ecological Risk Assessments - Interim Final

EPA Pesticide Factsheets

This document provides guidance to site managers and Remedial Project Managers who are legally responsible for the management of a site on how to design and conduct technically defensible ecological risk assessments for the Superfund program.

Evaluation of drainage pipe by field experimentation and supplemental laboratory experimentation : interim report No. 3.

DOT National Transportation Integrated Search

1981-11-01

The Louisiana Department of Transportation and Development reacts to a major problem when it attempts to shape and control drainage patterns along its right-of-ways. The Department's design engineers meet this challenge through proper section design ...

40 CFR 265.254 - Design and operating requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

....254 Section 265.254 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Waste Piles § 265.254 Design and operating requirements. The owner or operator of each...

Predicting clinical trial results based on announcements of interim analyses

PubMed Central

2014-01-01

Background Announcements of interim analyses of a clinical trial convey information about the results beyond the trial’s Data Safety Monitoring Board (DSMB). The amount of information conveyed may be minimal, but the fact that none of the trial’s stopping boundaries has been crossed implies that the experimental therapy is neither extremely effective nor hopeless. Predicting success of the ongoing trial is of interest to the trial’s sponsor, the medical community, pharmaceutical companies, and investors. We determine the probability of trial success by quantifying only the publicly available information from interim analyses of an ongoing trial. We illustrate our method in the context of the National Surgical Adjuvant Breast and Bowel (NSABP) trial, C-08. Methods We simulated trials based on the specifics of the NSABP C-08 protocol that were publicly available. We quantified the uncertainty around the treatment effect using prior weights for the various possibilities in light of other colon cancer studies and other studies of the investigational agent, bevacizumab. We considered alternative prior distributions. Results Subsequent to the trial’s third interim analysis, our predictive probabilities were: that the trial would eventually be successful, 48.0%; would stop for futility, 7.4%; and would continue to completion without statistical significance, 44.5%. The actual trial continued to completion without statistical significance. Conclusions Announcements of interim analyses provide information outside the DSMB’s sphere of confidentiality. This information is potentially helpful to clinical trial prognosticators. ‘Information leakage’ from standard interim analyses such as in NSABP C-08 is conventionally viewed as acceptable even though it may be quite revealing. Whether leakage from more aggressive types of adaptations is acceptable should be assessed at the design stage. PMID:24607270

Experimental model: dye penetration of extensive interim restorations used during endodontic treatment while under load in a multiple axis chewing simulator.

PubMed

Jensen, Arna-Lee; Abbott, Paul V

2007-10-01

The purpose of this study was to design an experimental model that allowed extensive endodontic interim restorations to be tested for dye penetration while under simulated masticatory load. Extracted premolar teeth had standardized mesio-occluso-distal cavities prepared, and the root canals were instrumented. A cotton wool pellet was placed in the pulp chamber, and the cavities were restored with Cavit, IRM, Ketac-Fil Plus, Ketac-Silver, or composite resin (Z100). They were subjected to the equivalent of 3 months of clinical load while exposed to methylene blue dye. Results of this study could not support IRM as a suitable interim endodontic restorative material to use in extensive cavities. The dye penetration in the Ketac-Fil Plus and Ketac-Silver specimens was not predictable, and the results suggested Cavit and Z100 composite resin require further investigations as potentially useful materials for this purpose.

SUSTAINABLE ALLOY DESIGN: SEARCHING FOR RARE EARTH ELEMENT ALTERNATIVES THROUGH CRYSTAL ENGINEERING

DTIC Science & Technology

2016-02-26

Property Maps to Guide Materials Design via Statistical Learning Summer Research Group Meeting – Materials by Design Los Alamos National Laboratory, July...Informatics, Rational design , Quantitative correlative spectroscopy and imaging, DFT, In situ high pressure mechanical property measurements, Superalloy...final, technical, interim, memorandum, master’s thesis, progress, quarterly, research , special, group study, etc. 3. DATES COVERED. Indicate the

A Design Study to Develop Young Children's Understanding of Multiplication and Division

ERIC Educational Resources Information Center

Bicknell, Brenda; Young-Loveridge, Jenny; Nguyen, Nhung

2016-01-01

This design study investigated the use of multiplication and division problems to help 5-year-old children develop an early understanding of multiplication and division. One teacher and her class of 15 5-year-old children were involved in a collaborative partnership with the researchers. The design study was conducted over two 4-week periods in…

Mobile Launch Platform Vehicle Assembly Area (SWMU 056) Biosparge Expansion Interim Measures Work Plan

NASA Technical Reports Server (NTRS)

Burcham, Michael S.; Daprato, Rebecca C.

2016-01-01

This document presents the design details for an Interim Measure (IM) Work Plan (IMWP) for the Mobile Launch Platform/Vehicle Assembly Building (MLPV) Area, located at the John F. Kennedy Space Center (KSC), Florida. The MLPV Area has been designated Solid Waste Management Unit Number 056 (SWMU 056) under KSC's Resource Conservation and Recovery Act (RCRA) Corrective Action Program. This report was prepared by Geosyntec Consultants (Geosyntec) for the National Aeronautics and Space Administration (NASA) under contract number NNK09CA02B and NNK12CA13B, project control number ENV1642. The Advanced Data Package (ADP) presentation covering the elements of this IMWP report received KSC Remediation Team (KSCRT) approval at the December 2015 Team Meeting; the meeting minutes are included in Appendix A.

Sample size determination in group-sequential clinical trials with two co-primary endpoints

PubMed Central

Asakura, Koko; Hamasaki, Toshimitsu; Sugimoto, Tomoyuki; Hayashi, Kenichi; Evans, Scott R; Sozu, Takashi

2014-01-01

We discuss sample size determination in group-sequential designs with two endpoints as co-primary. We derive the power and sample size within two decision-making frameworks. One is to claim the test intervention’s benefit relative to control when superiority is achieved for the two endpoints at the same interim timepoint of the trial. The other is when the superiority is achieved for the two endpoints at any interim timepoint, not necessarily simultaneously. We evaluate the behaviors of sample size and power with varying design elements and provide a real example to illustrate the proposed sample size methods. In addition, we discuss sample size recalculation based on observed data and evaluate the impact on the power and Type I error rate. PMID:24676799

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, L. M.; Environmental Science Division

In October, 2007, the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) presented the document Interim Measure Conceptual Design (Argonne 2007a) to the Kansas Department of Health and Environment, Bureau of Environmental Remediation (KDHE/BER), for a proposed non-emergency Interim Measure (IM) at the site of the former CCC/USDA grain storage facility in Centralia, Kansas (Figure 1.1). The IM was recommended to mitigate existing levels of carbon tetrachloride contamination identified in the vadose zone soils beneath the former facility and in the groundwater beneath and in the vicinity of the former facility, as well as to moderate or decreasemore » the potential future concentrations of carbon tetrachloride in the groundwater. The Interim Measure Conceptual Design (Argonne 2007a) was developed in accordance with the KDHE/BER Policy No.BERRS-029, Policy and Scope of Work: Interim Measures (KDHE 1996). The hydrogeologic, geochemical, and contaminant distribution characteristics of the Centralia site, as identified by the CCC/USDA, factored into the development of the nonemergency IM proposal. These characteristics were summarized in the Interim Measure Conceptual Design (Argonne 2007a) and were discussed in detail in previous Argonne reports (Argonne 2002a, 2003, 2004, 2005a,b,c, 2006a,b, 2007b). The identified remedial goals of the proposed IM were as follows: (1) To reduce the existing concentrations of carbon tetrachloride in groundwater in three 'hot spot' areas identified at the site (at SB01, SB05, and SB12-MW02; Figure 1.2) to levels acceptable to the KDHE. (2) To reduce carbon tetrachloride concentrations in the soils near the location of former soil boring SB12 and existing monitoring well MW02 (Figure 1.2) to levels below the KDHE Tier 2 Risk-Based Screening Level (RBSL) of 200 {micro}g/kg for this contaminant. To address these goals, the potential application of an in situ chemical reduction (ISCR) treatment technology, employing the use of the EHC{reg_sign} treatment materials marketed by Adventus Americas, Inc. (Freeport, Illinois), was recommended. The EHC materials are proprietary mixtures of food-grade organic carbon and zero-valent iron that are injected into the subsurface as a slurry (EHC) or in dissolved form (EHC-A) and subsequently released slowly into the formation. The materials are designed to create highly reducing geochemical conditions in the vadose and saturated zones that foster both thermodynamic and biological reductive dechlorination of carbon tetrachloride.« less

Evaluation of drainage pipe by field experimentation and supplemental laboratory experimentation : interim report No. 2.

DOT National Transportation Integrated Search

1978-03-01

Louisiana's Office of Highways reacts to a major problem when it attempts to shape and control drainage patterns along its right-of-ways. The Office's design engineers meet this challenge through proper section design and appropriate application of d...

Evaluation of drainage pipe by field experimentation and supplemental laboratory experimentation : interim report No. 1.

DOT National Transportation Integrated Search

1977-03-01

Louisiana's Office of Highways reacts to a major problem when it attempts to shape and control drainage patterns along its right-of-ways. The Office's design engineers meet this challenge through proper section design and appropriate application of d...

Feasibility evaluation of utilizing high strength concrete in design and construction of highway bridge structures : interim report.

DOT National Transportation Integrated Search

1992-12-01

The objective of this investigation was to evaluate the feasibility of using high-strength concrete in the design and construction of highway bridge structures. A literature search was conducted; a survey of five regional fabrication plants was perfo...

Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications.

PubMed

Graf, Alexandra C; Bauer, Peter; Glimm, Ekkehard; Koenig, Franz

2014-07-01

Sample size modifications in the interim analyses of an adaptive design can inflate the type 1 error rate, if test statistics and critical boundaries are used in the final analysis as if no modification had been made. While this is already true for designs with an overall change of the sample size in a balanced treatment-control comparison, the inflation can be much larger if in addition a modification of allocation ratios is allowed as well. In this paper, we investigate adaptive designs with several treatment arms compared to a single common control group. Regarding modifications, we consider treatment arm selection as well as modifications of overall sample size and allocation ratios. The inflation is quantified for two approaches: a naive procedure that ignores not only all modifications, but also the multiplicity issue arising from the many-to-one comparison, and a Dunnett procedure that ignores modifications, but adjusts for the initially started multiple treatments. The maximum inflation of the type 1 error rate for such types of design can be calculated by searching for the "worst case" scenarios, that are sample size adaptation rules in the interim analysis that lead to the largest conditional type 1 error rate in any point of the sample space. To show the most extreme inflation, we initially assume unconstrained second stage sample size modifications leading to a large inflation of the type 1 error rate. Furthermore, we investigate the inflation when putting constraints on the second stage sample sizes. It turns out that, for example fixing the sample size of the control group, leads to designs controlling the type 1 error rate. © 2014 The Author. Biometrical Journal published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Statistical controversies in clinical research: building the bridge to phase II-efficacy estimation in dose-expansion cohorts.

PubMed

Boonstra, P S; Braun, T M; Taylor, J M G; Kidwell, K M; Bellile, E L; Daignault, S; Zhao, L; Griffith, K A; Lawrence, T S; Kalemkerian, G P; Schipper, M J

2017-07-01

Regulatory agencies and others have expressed concern about the uncritical use of dose expansion cohorts (DECs) in phase I oncology trials. Nonetheless, by several metrics-prevalence, size, and number-their popularity is increasing. Although early efficacy estimation in defined populations is a common primary endpoint of DECs, the types of designs best equipped to identify efficacy signals have not been established. We conducted a simulation study of six phase I design templates with multiple DECs: three dose-assignment/adjustment mechanisms multiplied by two analytic approaches for estimating efficacy after the trial is complete. We also investigated the effect of sample size and interim futility analysis on trial performance. Identifying populations in which the treatment is efficacious (true positives) and weeding out inefficacious treatment/populations (true negatives) are competing goals in these trials. Thus, we estimated true and false positive rates for each design. Adaptively updating the MTD during the DEC improved true positive rates by 8-43% compared with fixing the dose during the DEC phase while maintaining false positive rates. Inclusion of an interim futility analysis decreased the number of patients treated under inefficacious DECs without hurting performance. A substantial gain in efficiency is obtainable using a design template that statistically models toxicity and efficacy against dose level during expansion. Design choices for dose expansion should be motivated by and based upon expected performance. Similar to the common practice in single-arm phase II trials, cohort sample sizes should be justified with respect to their primary aim and include interim analyses to allow for early stopping. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Development of an improved overlay design procedure for Oregon : vol. I, interim report, background and framework.

DOT National Transportation Integrated Search

1986-12-01

This report is the first in a three-volume series dealing with the development of an improved overlay design procedure for Oregon. This report presents the results of the first-year findings and includes: (1) a detailed review of the literature; (2) ...

10 CFR 431.401 - Petitions for waiver, and applications for interim waiver, of test procedure.

Code of Federal Regulations, 2013 CFR

2013-01-01

... more design characteristics which prevent testing of the basic model according to the prescribed test... its true energy consumption characteristics as to provide materially inaccurate comparative data. (2... design characteristic(s) constituting the grounds for the petition, and the specific requirements sought...

10 CFR 430.27 - Petitions for waiver and applications for interim waiver.

Code of Federal Regulations, 2010 CFR

2010-01-01

... design characteristics which either prevent testing of the basic model according to the prescribed test... faucets, showerheads, water closets, and urinals) as to provide materially inaccurate comparative data. (2... particular basic model(s) for which a waiver is requested, the design characteristic(s) constituting the...

10 CFR 431.401 - Petitions for waiver, and applications for interim waiver, of test procedure.

Code of Federal Regulations, 2011 CFR

2011-01-01

... more design characteristics which prevent testing of the basic model according to the prescribed test... its true energy consumption characteristics as to provide materially inaccurate comparative data. (2... particular basic model(s) for which a waiver is requested, the design characteristic(s) constituting the...

10 CFR 431.401 - Petitions for waiver, and applications for interim waiver, of test procedure.

Code of Federal Regulations, 2012 CFR

2012-01-01

... more design characteristics which prevent testing of the basic model according to the prescribed test... its true energy consumption characteristics as to provide materially inaccurate comparative data. (2... design characteristic(s) constituting the grounds for the petition, and the specific requirements sought...

10 CFR 430.27 - Petitions for waiver and applications for interim waiver.

Code of Federal Regulations, 2013 CFR

2013-01-01

... design characteristics which either prevent testing of the basic model according to the prescribed test... faucets, showerheads, water closets, and urinals) as to provide materially inaccurate comparative data. (2... contains a design characteristic which either prevents testing of the basic model according to the...

10 CFR 430.27 - Petitions for waiver and applications for interim waiver.

Code of Federal Regulations, 2012 CFR

2012-01-01

... design characteristics which either prevent testing of the basic model according to the prescribed test... faucets, showerheads, water closets, and urinals) as to provide materially inaccurate comparative data. (2... contains a design characteristic which either prevents testing of the basic model according to the...

10 CFR 431.401 - Petitions for waiver, and applications for interim waiver, of test procedure.

Code of Federal Regulations, 2014 CFR

2014-01-01

... more design characteristics which prevent testing of the basic model according to the prescribed test... its true energy consumption characteristics as to provide materially inaccurate comparative data. (2... design characteristic(s) constituting the grounds for the petition, and the specific requirements sought...

10 CFR 431.401 - Petitions for waiver, and applications for interim waiver, of test procedure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... more design characteristics which prevent testing of the basic model according to the prescribed test... its true energy consumption characteristics as to provide materially inaccurate comparative data. (2... particular basic model(s) for which a waiver is requested, the design characteristic(s) constituting the...

10 CFR 430.27 - Petitions for waiver and applications for interim waiver.

Code of Federal Regulations, 2011 CFR

2011-01-01

... design characteristics which either prevent testing of the basic model according to the prescribed test... faucets, showerheads, water closets, and urinals) as to provide materially inaccurate comparative data. (2... particular basic model(s) for which a waiver is requested, the design characteristic(s) constituting the...

10 CFR 430.27 - Petitions for waiver and applications for interim waiver.

Code of Federal Regulations, 2014 CFR

2014-01-01

... design characteristics which either prevent testing of the basic model according to the prescribed test... faucets, showerheads, water closets, and urinals) as to provide materially inaccurate comparative data. (2... contains a design characteristic which either prevents testing of the basic model according to the...

77 FR 16661 - Tuberculosis in Cattle and Bison; State and Zone Designations; NM; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-22

...-0124] Tuberculosis in Cattle and Bison; State and Zone Designations; NM; Correction AGENCY: Animal and... in the regulatory text of an interim rule that amended the bovine tuberculosis regulations by establishing two separate zones with different tuberculosis risk classifications for the State of New Mexico...

76 FR 61253 - Tuberculosis in Cattle and Bison; State and Zone Designations; Minnesota

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-04

.... APHIS-2011-0100] Tuberculosis in Cattle and Bison; State and Zone Designations; Minnesota AGENCY: Animal... are amending the bovine tuberculosis regulations regarding State and zone classifications by... for tuberculosis. DATES: This interim rule is effective October 4, 2011. We will consider all comments...

Computer Science 205. Interim Guide, 1983.

ERIC Educational Resources Information Center

Manitoba Dept. of Education, Winnipeg.

This guide to a 4-unit, required high school computer science course emphasizes problem solving and computer programming and is designed for use with a variety of hardware configurations and programming languages. An overview covers the program rationale, goals and objectives, program design and description, program implementation, time allotment,…

Development of performance specifications for collision avoidance systems for lane change crashes. Task 6, interim report : testbed systems design and associated facilities

DOT National Transportation Integrated Search

2001-11-01

This report documents the design of an on-road testbed vehicle. The purposes of this testbed are twofold: (1) Establish a foundation for estimating lane change collision avoidance effectiveness, and (2) provide information pertinent to setting perfor...

Miscellaneous wood structures

Treesearch

Michael A. Ritter; Keith F. Faherty

1999-01-01

This section addresses the design of two types of glulam timber bridges : beam bridges with transverse decks and longitudinal glulam deck (slab) bridges. The material presented in the section is based on the 1992 edition of the AASHTO Standard Specifications for Highway Bridges (AASHTO specifications), including interim specifications through 1993. When specific design...

Shuttle/IUS performance for planetary missions. [Interim Upper Stage

NASA Technical Reports Server (NTRS)

Cork, M. J.; Driver, J. M.; Wright, J. L.

1975-01-01

Potential requirements for planetary missions in the 1980s, capabilities of the Interim Upper Stage (IUS) candidates to perform those missions, and Shuttle/IUS mission profile options for performance enhancement are examined. The most demanding planetary missions are the Pioneer Saturn/Uranus/Titan Probe and the Mariner-class orbiters of Mercury, Jupiter, and Saturn. Options available to designers of these missions will depend on the specific IUS selected for development and the programmatic phasing of the IUS and the NASA Tug. Use of Shuttle elliptic orbits as initial conditions for IUS ignition offers significant performance improvements; specific values are mission dependent.

Instructional System Design for Executive Orientation and Project Management Training Packages, Technical Memorandum No. 3. Interim Report. RF Project No. 3131-A1.

ERIC Educational Resources Information Center

Cook, Desmond L.; And Others

This memorandum reports on the third phase, the design, of a four-phase project to design project management training materials for local educational agencies. The first section of the memorandum explains some considerations regarding management education and the organization of the report. Section 2 presents the design specifications for the…

National Program for Inspection of Non-Federal Dams. Collins Company Upper Dam (CT 00674), Connecticut River Basin, Canton, Connecticut. Phase I Inspection Report.

DTIC Science & Technology

1979-07-01

Engineering Division p 0 CAR WE H FRZIAN, NENBER Design Branch Engineering Division J SEPE FIN~EGAN, JR.,CIV ater Control Branch * Engineering Division...Operator g. Purpose of Dam h. Design and Construction History i. Normal Operational Procedures 1.3 PERTINENT DATA ........................... 4 a...Tunnel i. Spillways j. Regulating Outlets SECTION 2: ENGINEERING DATA 2.1 DESIGN .............................. 9 a. Available Data b. Design Features c

Analysis of Transportation Options for Commercial Spent Fuel in the U.S.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalinina, Elena; Busch, Ingrid Karin

The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S.more » Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the 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high and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF) and high and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF) and highand associated transportation of spent nuclear fuel (SNF) and high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF) and high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent 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MFTF-. cap alpha. + T progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, W.D.

1985-04-01

Early in FY 1983, several upgrades of the Mirror Fusion Test Facility (MFTF-B) at Lawrence Livermore National Laboratory (LLNL) were proposed to the fusion community. The one most favorably received was designated MFTF-..cap alpha..+T. The engineering design of this device, guided by LLNL, has been a principal activity of the Fusion Engineering Design Center during FY 1983. This interim progress report represents a snapshot of the device design, which was begun in FY 1983 and will continue for several years. The report is organized as a complete design description. Because it is an interim report, some parts are incomplete; theymore » will be supplied as the design study proceeds. As described in this report, MFTF-..cap alpha..+T uses existing facilities, many MFTF-B components, and a number of innovations to improve on the physics parameters of MFTF-B. It burns deuterium-tritium and has a central-cell Q of 2, a wall loading GAMMA/sub n/ of 2 MW/m/sup 2/ (with a central-cell insert module), and an availability of 10%. The machine is fully shielded, allows hands-on maintenance of components outside the vacuum vessel 24 h after shutdown, and has provisions for repair of all operating components.« less

Jointless bridges : interim report.

DOT National Transportation Integrated Search

1980-01-01

Presented is a summary of jointless bridge designs as twelve states; namely, California, Colorado, Idaho, Iowa, Kansas, Missouri, Nebraska, North Dakota, South Dakota, Tennessee, Virginia, and Wisconsin. Most of these states use some form of integral...

Pembrolizumab for Ipilimumab-Resistant Melanoma

Cancer.gov

KEYNOTE-002 was designed to test the safety and efficacy of two doses of pembrolizumab compared with chemotherapy in patients with ipilimumab-resistant melanoma; interim results show that pembrolizumab improves progression-free survival for these patients

Interim Procedures Safeguarding Mobile Devices during International Travel

EPA Pesticide Factsheets

This procedure is for safeguarding EPA information and systems for all employees, contractors, and other users while on international travel or to specifically designated locations within the United States and foreign embassies.

The Time Needed to Implement the Blue Ribbon Commission Recommendation on Interim Storage - 13124

DOE Office of Scientific and Technical Information (OSTI.GOV)

Voegele, Michael D.; Vieth, Donald

2013-07-01

The report of the Blue Ribbon Commission on America's Nuclear Future [1] makes a number of important recommendations to be considered if Congress elects to redirect U.S. high-level radioactive waste disposal policy. Setting aside for the purposes of this discussion any issues related to political forces leading to stopping progress on the Yucca Mountain project and driving the creation of the Commission, an important recommendation of the Commission was to institute prompt efforts to develop one or more consolidated storage facilities. The Blue Ribbon Commission noted that this recommended strategy for future storage and disposal facilities and operations should bemore » implemented regardless of what happens with Yucca Mountain. It is too easy, however, to focus on interim storage as an alternative to geologic disposal. The Blue Ribbon Commission report does not go far enough in addressing the magnitude of the contentious problems associated with reopening the issues of relative authorities of the states and federal government with which Congress wrestled in crafting the Nuclear Waste Policy Act [2]. The Blue Ribbon Commission recommendation for prompt adoption of an interim storage program does not appear to be fully informed about the actions that must be taken, the relative cost of the effort, or the realistic time line that would be involved. In essence, the recommendation leaves to others the details of the systems engineering analyses needed to understand the nature and details of all the operations required to reach an operational interim storage facility without derailing forever the true end goal of geologic disposal. The material presented identifies a number of impediments that must be overcome before the country could develop a centralized federal interim storage facility. In summary, and in the order presented, they are: 1. Change the law, HJR 87, PL 107-200, designating Yucca Mountain for the development of a repository. 2. Bring new nuclear waste legislation to the floor of the Senate, overcoming existing House support for Yucca Mountain; 3. Change the longstanding focus of Congress from disposal to storage; 4. Change the funding concepts embodied in the Nuclear Waste Policy Act to allow the Nuclear Waste fund to be used to pay for interim storage; 5. Reverse the Congressional policy not to give states or tribes veto or consent authority, and to reserve to Congress the authority to override a state or tribal disapproval; 6. Promulgate interim storage facility siting regulations to reflect the new policies after such changes to policy and law; 7. Complete already underway changes to storage and transportation regulations, possibly incorporating changes to reflect changes to waste disposal law; 8. Promulgate new repository siting regulations if the interim storage facility is to support repository development; 9. Identify volunteer sites, negotiate agreements, and get Congressional approval for negotiated benefits packages; 10. Design, License and develop the interim storage facility. The time required to accomplish these ten items depends on many factors. The estimate developed assumes that certain of the items must be completed before other items are started; given past criticisms of the current program, such an assumption appears appropriate. Estimated times for completion of individual items are based on historical precedent. (authors)« less

Creation of a 3-dimensional virtual dental patient for computer-guided surgery and CAD-CAM interim complete removable and fixed dental prostheses: A clinical report.

PubMed

Harris, Bryan T; Montero, Daniel; Grant, Gerald T; Morton, Dean; Llop, Daniel R; Lin, Wei-Shao

2017-02-01

This clinical report proposes a digital workflow using 2-dimensional (2D) digital photographs, a 3D extraoral facial scan, and cone beam computed tomography (CBCT) volumetric data to create a 3D virtual patient with craniofacial hard tissue, remaining dentition (including surrounding intraoral soft tissue), and the realistic appearance of facial soft tissue at an exaggerated smile under static conditions. The 3D virtual patient was used to assist the virtual diagnostic tooth arrangement process, providing patient with a pleasing preoperative virtual smile design that harmonized with facial features. The 3D virtual patient was also used to gain patient's pretreatment approval (as a communication tool), design a prosthetically driven surgical plan for computer-guided implant surgery, and fabricate the computer-aided design and computer-aided manufacturing (CAD-CAM) interim prostheses. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

40 CFR 86.1810-01 - General standards; increase in emissions; unsafe conditions; waivers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 2 and interim non-Tier 2 ethanol fueled vehicles. (a) Any device, system or element of design... “lean-on-cruise” strategies are incorporated into the vehicle design. A “lean-on-cruise” air-fuel... standard. The Administrator may require the manufacturer to provide comparative test data which clearly...

76 FR 59953 - Designation of Agent To Receive Notification of Claimed Infringement

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

... for comment. The interim regulations have functioned satisfactorily for many years, but issues have... designation of agent using the online template be required, either annually, every two years, or at some other... at least every two years, but the Office invites comment as to the appropriate time period. As is...

Development of performance specifications for collision avoidance systems for lane change, merging, and backing. Task 6, Interim report : testbed systems design and associated facilities

DOT National Transportation Integrated Search

1997-05-01

This report represents the documentation of the design of the testbed. The purposes of the testbed are twofold 1) Establish a foundation for estimating collision avoidance effectiveness and 2) Provide information pertinent to setting performance spec...

40 CFR 265.442 - Design and installation of new drip pads.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Design and installation of new drip pads. 265.442 Section 265.442 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Drip Pads §...

Comparing the Impacts of Tutorial and Edutainment Software Programs on Students' Achievements, Misconceptions, and Attitudes towards Biology

ERIC Educational Resources Information Center

Kara, Yilmaz; Yesilyurt, Selami

2008-01-01

The purpose of this study was to investigate the effects of tutorial and edutainment design of instructional software programs related to the "cell division" topic on student achievements, misconceptions and attitudes. An experimental research design including the cell division achievement test (CAT), the cell division concept test (CCT) and…

76 FR 4369 - Interim Deputation Agreements; Interim BIA Adult Detention Facility Guidelines

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... Adult Detention Facility Guidelines AGENCY: Bureau of Indian Affairs, Interior. ACTION: Notice. SUMMARY: This notice announces the online publication of the Interim BIA Adult Detention Facility Guidelines and... Indian Affairs Web site. DATES: These Interim BIA Adult Detention Facility Guidelines and Interim Model...

76 FR 17160 - Office of New Reactors; Final Interim Staff Guidance on the Review of Nuclear Power Plant Designs...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-28

...The NRC staff is issuing its Final Interim Staff Guidance (ISG) DC/COL-ISG-021 titled ``Interim Staff Guidance on the Review of Nuclear Power Plant Designs Using a Gas Turbine Driven Standby Emergency Alternating Current Power System,'' Agencywide Documents Access and Management System (ADAMS) Accession No. ML102510119 for DC/ COL-ISG-021 and ADAMS Accession No. ML102510164 for Attachment 1 to DC/ COL-ISG-021. This ISG provides new guidance for applicants submitting a combined license (COL) or design certification (DC) application for new nuclear power reactors under Title 10 of the Code of Federal Regulations, part 52. In addition, it supplements the guidance provided to the NRC staff in NUREG-0800, ``Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants,'' March 2007, Standard Review Plan (SRP), Section 8.3.1 and Sections 9.5.4 through 9.5.8. The NRC staff issues DC/COL-ISGs to facilitate activities associated with NRC review of applications for DCs and COLs. The NRC staff intends to incorporate DC/COL-ISG-021 into the next revision of SRP Section 8.3.1 and Sections 9.5.4 through 9.5.8 and Regulatory Guide 1.206, ``Combined License Applications for Nuclear Power Plants (LWR Edition),'' June 2007. Disposition: On February 3, 2010, the NRC staff issued proposed DC/ COL-ISG-021 on ``Review of Nuclear Power Plant Designs Using a Gas Turbine Driven Standby Emergency Alternating Current Power System,'' ADAMS Accession No. ML092640035. The NRC staff received comments on the proposed guidance. This final issuance resolves the majority of the comments. The NRC staff responses to these comments can be found in ADAMS Accession No. ML102510176.

Design and fabrication considerations for stainless steel liquid helium jackets surrounding SCRF cavities

NASA Astrophysics Data System (ADS)

Bonnema, E. C.; Cunningham, E. K.; Rumel, J. D.

2014-01-01

The Department of Energy requires its subcontractors to meet 10 CFR 851 Appendix A Part 4 for all new pressure vessels and pressure piping. The stainless steel pressure vessel boundaries surrounding SCRF cavities fall under this requirement. Methods for meeting this requirement include design and fabrication of the pressure vessels to meet the requirements of the ASME Boiler & Pressure Vessel Code Section VIII Division 1 or Division 2. Design considerations include determining whether the configuration of the SCRF cavity can be accommodated under the rules of Division 1 or must be analyzed under Division 2 Part 4 Design by Rule Requirements or Part 5 Design by Analysis Requirements. Regardless of the Division or Part choice, designers will find the rules of the ASME Code require thicker pressure boundary members, larger welds, and additional non-destructive testing and quality assurance requirements. These challenges must be met and overcome by the fabricator through the development of robust, detailed, and repeatable manufacturing processes. In this paper we discuss the considerations for stainless steel pressure vessels that must meet the ASME Code and illustrate the discussion with examples from direct experience fabricating such vessels.

Two-stage phase II oncology designs using short-term endpoints for early stopping.

PubMed

Kunz, Cornelia U; Wason, James Ms; Kieser, Meinhard

2017-08-01

Phase II oncology trials are conducted to evaluate whether the tumour activity of a new treatment is promising enough to warrant further investigation. The most commonly used approach in this context is a two-stage single-arm design with binary endpoint. As for all designs with interim analysis, its efficiency strongly depends on the relation between recruitment rate and follow-up time required to measure the patients' outcomes. Usually, recruitment is postponed after the sample size of the first stage is achieved up until the outcomes of all patients are available. This may lead to a considerable increase of the trial length and with it to a delay in the drug development process. We propose a design where an intermediate endpoint is used in the interim analysis to decide whether or not the study is continued with a second stage. Optimal and minimax versions of this design are derived. The characteristics of the proposed design in terms of type I error rate, power, maximum and expected sample size as well as trial duration are investigated. Guidance is given on how to select the most appropriate design. Application is illustrated by a phase II oncology trial in patients with advanced angiosarcoma, which motivated this research.

24 CFR 35.820 - Interim controls.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Interim controls. 35.820 Section 35...-Possession Multifamily Property § 35.820 Interim controls. HUD shall conduct interim controls in accordance... accordance with § 35.815. Interim controls are considered completed when clearance is achieved in accordance...

24 CFR 35.820 - Interim controls.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Interim controls. 35.820 Section 35...-Possession Multifamily Property § 35.820 Interim controls. HUD shall conduct interim controls in accordance... accordance with § 35.815. Interim controls are considered completed when clearance is achieved in accordance...

Cell Division Synchronization

DTIC Science & Technology

The report summarizes the progress in the design and construction of automatic equipment for synchronizing cell division in culture by periodic...Concurrent experiments in hypothermic synchronization of algal cell division are reported.

75 FR 4822 - Decision To Evaluate a Petition To Designate a Class of Employees for the Lawrence Livermore...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-29

...: Lawrence Livermore National Laboratory. Location: Livermore, California. Job Titles and/or Job Duties: All... L. Hinnefeld, Interim Director, Office of Compensation Analysis and Support, National Institute for...

Louisiana experimental base project : interim report No. 1.

DOT National Transportation Integrated Search

1979-11-01

The Louisiana Experimental Base Project is a research study evaluating the design/performance characteristics of three types of base courses as incorporated into comparable flexible pavement systems on a full-scale test road. Fourteen different test ...

DEET

MedlinePlus

... of designated critical habitat for all currently registered uses of DEET. EPA issued an Interim Decision for DEET in September 2014. We concluded that: no additional data are required at this time; and no changes to the affected registrations or their labeling are ...

75 FR 984 - Draft Recommended Interim Preliminary Remediation Goals for Dioxin in Soil at CERCLA and RCRA Sites

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-07

... Recommended Interim Preliminary Remediation Goals for Dioxin in Soil at CERCLA and RCRA Sites AGENCY... Recommended Interim Preliminary Remediation Goals for Dioxin in Soil at Comprehensive Environmental Response... interim PRGs for dioxin in soil. These draft recommended interim PRGs were calculated using existing, peer...

46 CFR 147A.9 - Persons in charge of fumigation and the vessel; designation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 5 2010-10-01 2010-10-01 false Persons in charge of fumigation and the vessel; designation. 147A.9 Section 147A.9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES INTERIM REGULATIONS FOR SHIPBOARD FUMIGATION General § 147A.9 Persons in charge of fumigation and...

46 CFR 147A.9 - Persons in charge of fumigation and the vessel; designation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 5 2011-10-01 2011-10-01 false Persons in charge of fumigation and the vessel; designation. 147A.9 Section 147A.9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES INTERIM REGULATIONS FOR SHIPBOARD FUMIGATION General § 147A.9 Persons in charge of fumigation and...

46 CFR 147A.9 - Persons in charge of fumigation and the vessel; designation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 5 2014-10-01 2014-10-01 false Persons in charge of fumigation and the vessel; designation. 147A.9 Section 147A.9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES INTERIM REGULATIONS FOR SHIPBOARD FUMIGATION General § 147A.9 Persons in charge of fumigation and...

46 CFR 147A.9 - Persons in charge of fumigation and the vessel; designation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 5 2012-10-01 2012-10-01 false Persons in charge of fumigation and the vessel; designation. 147A.9 Section 147A.9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES INTERIM REGULATIONS FOR SHIPBOARD FUMIGATION General § 147A.9 Persons in charge of fumigation and...

46 CFR 147A.9 - Persons in charge of fumigation and the vessel; designation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 5 2013-10-01 2013-10-01 false Persons in charge of fumigation and the vessel; designation. 147A.9 Section 147A.9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES INTERIM REGULATIONS FOR SHIPBOARD FUMIGATION General § 147A.9 Persons in charge of fumigation and...

Effectiveness Of The Individual Riflemen In An Infantry Squad

DTIC Science & Technology

2017-12-01

adversaries. 14. SUBJECT TERMS individual carbine, interim combat service rifle, squad designated marksman rifle, commercial- off-the-shelf...7 5th–95th Percentile. Source: El Creative Advertising and Design (2007...but does not have overwhelming firepower compared to enemy infantry supported by an armored or 4 motorized assets (DA, 2006b). In order to achieve

Evaluation of Worker Profiling and Reemployment Services Systems: Interim Report. Unemployment Insurance Occasional Paper 96-1.

ERIC Educational Resources Information Center

Hawkins, Evelyn K.; And Others

The Evaluation of Worker Profiling and Reemployment Services (WPRS) systems was designed to provide the U.S. Department of Labor information on how states are designing, implementing, and operating their worker profiling and reemployment services systems for dislocated workers and to compare the effectiveness of different state approaches to…

A modified varying-stage adaptive phase II/III clinical trial design.

PubMed

Dong, Gaohong; Vandemeulebroecke, Marc

2016-07-01

Conventionally, adaptive phase II/III clinical trials are carried out with a strict two-stage design. Recently, a varying-stage adaptive phase II/III clinical trial design has been developed. In this design, following the first stage, an intermediate stage can be adaptively added to obtain more data, so that a more informative decision can be made. Therefore, the number of further investigational stages is determined based upon data accumulated to the interim analysis. This design considers two plausible study endpoints, with one of them initially designated as the primary endpoint. Based on interim results, another endpoint can be switched as the primary endpoint. However, in many therapeutic areas, the primary study endpoint is well established. Therefore, we modify this design to consider one study endpoint only so that it may be more readily applicable in real clinical trial designs. Our simulations show that, the same as the original design, this modified design controls the Type I error rate, and the design parameters such as the threshold probability for the two-stage setting and the alpha allocation ratio in the two-stage setting versus the three-stage setting have a great impact on the design characteristics. However, this modified design requires a larger sample size for the initial stage, and the probability of futility becomes much higher when the threshold probability for the two-stage setting gets smaller. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

40 CFR 745.83 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... with the manufacturer's instructions. Interim controls means a set of measures designed to temporarily... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED... disposable cleaning cloths with the card, whether post-renovation cleaning has been properly completed...

40 CFR 745.83 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... with the manufacturer's instructions. Interim controls means a set of measures designed to temporarily... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED... disposable cleaning cloths with the card, whether post-renovation cleaning has been properly completed...

40 CFR 745.83 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... with the manufacturer's instructions. Interim controls means a set of measures designed to temporarily... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED... disposable cleaning cloths with the card, whether post-renovation cleaning has been properly completed...

Marine Natural Product Chemistry and the Interim: A Novel Approach

ERIC Educational Resources Information Center

Bland, Jeffrey S.; Medcalf, Darrell G.

1974-01-01

Describes a course designed to strengthen a student's background in organic chemistry, demonstrate the interfacing of chemistry and biology, expose undergraduates to graduate research, provide familiarity with instrumentation, and provide a novel field experience. (Author/GS)

GUIDE TO CONDUCTING TREATABILITY STUDIES UNDER CERCLA: SOIL WASHING - INTERIM GUIDANCE

EPA Science Inventory

Systematically conducted, well-documented treatability studies are an important component of the remedial investigation/feasibility study (RI/FS) process and the remedial design/remedial action (RD/RA) process under the Comprehensive Environmental Response, Compensation, and Liab...

Evaluation of joint sealant materials : interim report No. 1.

DOT National Transportation Integrated Search

1972-03-01

This report illustrates some of the problems caused by ineffectively sealed joints and points to the great need for properly sealing joints in both concrete pavements and structures. : The principles of design including slab lengths, joint dimensions...

GUIDE FOR CONDUCTING TREATABILITY STUDIES UNDER CERCLA: SOLVENT EXTRACTION - INTERIM GUIDANCE

EPA Science Inventory

Systematically conducted, well-documented treatability studies are an important component of the remedial investigation/feasibility study (RI/FS) process and the remedial design/remedial action (RD/RA) process under the Comprehensive Environmental Response, Compensation and Liabi...

GUIDE FOR CONDUCTING TREATABILITY STUDIES UNDER CERCLA: THERMAL DESORPTION - INTERIM GUIDANCE

EPA Science Inventory

Systematically conducted, well-documented treatability studies are an important component of the remedial investigation/feasibility study (RI/FS) process and the remedial design remedial action (RD/RA) process under the Comprehensive Environmental Response, Compensation, and Liab...

The Impact of Operating Parameters and Correlated Parameters for Extended BWR Burnup Credit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ade, Brian J.; Marshall, William B. J.; Ilas, Germina

Applicants for certificates of compliance for spent nuclear fuel (SNF) transportation and dry storage systems perform analyses to demonstrate that these systems are adequately subcritical per the requirements of Title 10 of the Code of Federal Regulations (10 CFR) Parts 71 and 72. For pressurized water reactor (PWR) SNF, these analyses may credit the reduction in assembly reactivity caused by depletion of fissile nuclides and buildup of neutron-absorbing nuclides during power operation. This credit for reactivity reduction during depletion is commonly referred to as burnup credit (BUC). US Nuclear Regulatory Commission (NRC) staff review BUC analyses according to the guidancemore » in the Division of Spent Fuel Storage and Transportation Interim Staff Guidance (ISG) 8, Revision 3, Burnup Credit in the Criticality Safety Analyses of PWR Spent Fuel in Transportation and Storage Casks.« less

Reliability and the design process at Honeywell Avionics Division

NASA Technical Reports Server (NTRS)

Bezat, A.

1981-01-01

The division's philosophy for designed-in reliability and a comparison of reliability programs for space, manned military aircraft, and commercial aircraft, are presented. Topics include: the reliability interface with design and production; the concept phase through final proposal; the design, development, test and evaluation phase; the production phase; and the commonality among space, military, and commercial avionics.

Maximum inflation of the type 1 error rate when sample size and allocation rate are adapted in a pre-planned interim look.

PubMed

Graf, Alexandra C; Bauer, Peter

2011-06-30

We calculate the maximum type 1 error rate of the pre-planned conventional fixed sample size test for comparing the means of independent normal distributions (with common known variance) which can be yielded when sample size and allocation rate to the treatment arms can be modified in an interim analysis. Thereby it is assumed that the experimenter fully exploits knowledge of the unblinded interim estimates of the treatment effects in order to maximize the conditional type 1 error rate. The 'worst-case' strategies require knowledge of the unknown common treatment effect under the null hypothesis. Although this is a rather hypothetical scenario it may be approached in practice when using a standard control treatment for which precise estimates are available from historical data. The maximum inflation of the type 1 error rate is substantially larger than derived by Proschan and Hunsberger (Biometrics 1995; 51:1315-1324) for design modifications applying balanced samples before and after the interim analysis. Corresponding upper limits for the maximum type 1 error rate are calculated for a number of situations arising from practical considerations (e.g. restricting the maximum sample size, not allowing sample size to decrease, allowing only increase in the sample size in the experimental treatment). The application is discussed for a motivating example. Copyright © 2011 John Wiley & Sons, Ltd.

Sample size re-assessment leading to a raised sample size does not inflate type I error rate under mild conditions.

PubMed

Broberg, Per

2013-07-19

One major concern with adaptive designs, such as the sample size adjustable designs, has been the fear of inflating the type I error rate. In (Stat Med 23:1023-1038, 2004) it is however proven that when observations follow a normal distribution and the interim result show promise, meaning that the conditional power exceeds 50%, type I error rate is protected. This bound and the distributional assumptions may seem to impose undesirable restrictions on the use of these designs. In (Stat Med 30:3267-3284, 2011) the possibility of going below 50% is explored and a region that permits an increased sample size without inflation is defined in terms of the conditional power at the interim. A criterion which is implicit in (Stat Med 30:3267-3284, 2011) is derived by elementary methods and expressed in terms of the test statistic at the interim to simplify practical use. Mathematical and computational details concerning this criterion are exhibited. Under very general conditions the type I error rate is preserved under sample size adjustable schemes that permit a raise. The main result states that for normally distributed observations raising the sample size when the result looks promising, where the definition of promising depends on the amount of knowledge gathered so far, guarantees the protection of the type I error rate. Also, in the many situations where the test statistic approximately follows a normal law, the deviation from the main result remains negligible. This article provides details regarding the Weibull and binomial distributions and indicates how one may approach these distributions within the current setting. There is thus reason to consider such designs more often, since they offer a means of adjusting an important design feature at little or no cost in terms of error rate.

[Burden on designated hospitals when they receive inpatients from distant places in accordance with the Medical Treatment and Supervision Act].

PubMed

Miyata, Ryoji; Oguchi, Yoshiyo; Fujii, Yasuo; Kobayashi, Yukie

2009-01-01

The current Medical Treatment and Supervision Act places a burden on designated psychiafric hospitals with forensic wards. We aimed to clarify the rate of discharge beyond the jurisdictional catchment area, for which overnight training becomes quite cost-ineffective, as hospital staff must accompany the patients home. On September 30, 2008, there were 16 designated hospitals in Japan, and 447 inpatients in these hospitals. They were the subjects of this study. We collected information on the 447 subjects regarding the postdischarge administrative division, the nearest railway station to the postdischarge residential location, "treatment stage", "overnight training" at the postdischarge residential location, and trouble during "overnight training". We analyzed the collected data using the "designated bed sufficiency ratio". We divided the 447 subjects into three groups: (1) Home inpatient group (home group); the administrative division of his/her postdischarge residential area is the same administrative division as the designated hospital. (2) Inpatient within a jurisdiction group (within group) ; the administrative division of his/her postdischarge residential area is not the same as the designated hospital but is in any administrative division within a jurisdiction of the Japanese Regional Bureau of Health and Welfare. (3) Inpatient outside a jurisdiction group (outside group) ; the administrative division of his/her postdischarge residential area is not the same as the designated hospital but is any administrative division outside a jurisdiction of the Japanese Regional Bureau of Health and Welfare. We compared: (1) the time required to travel to the railway station nearest the postdischarge residential location (time required), (2) traveling expenses, and (3) the distance from the railway station nearest the designated hospital to that of the postdischarge residential location (distance) between the three groups. We also analyzed staff comments regarding "overnight training". The lack of designated beds was a serious problem in two jurisdictions of Kinki and the Hokkaido Regional Bureau of Health and Welfare, with a "designated bed sufficient ratio" of 0.08 and 0.00, respectively. Twenty-four Japanese administrative divisions had no designated beds, while 37 administrative divisions had less than 10 inpatients at the time of the survey. The numbers of people in the "home group", "within group", and "outside group" were 125 (28.0%), 166 (37.1%), and 145 (32.4%), respectively. The "time required", traveling expenses, and distance were 1: 00, Yen 735, and 29.8 km in the "home group", 2: 51, Yen 5,764, and 165.3 km in the "within group", and 4: 14, Yen 20,565, and 694.6 km in the "outside group". Seventy-nine (59.4%) of 133 subjects who were at the "return to community stage" had already experienced "overnight training". No difference was found in the rate of "overnight training" between the "home group", "within group", and "outside group". Staff comments included difficulties in providing staff for "overnight training", responsibilities during "overnight training", and difficulties in finding places of residence in the inpatients' hometowns. Because of the lack and maldistribution of designated beds in Japan, many patients are reluctantly admitted to designated hospitals far from their postdischarge residential areas, burdening not only hospital staff but also families and the inpatients themselves. Increasing the number of designated beds will solve this problem. An effective way would be to set up a ward with a small-scale designated unit (less than 15 beds) in the 24 administrative divisions where there are no designaed beds at present.

Abradable compressor and turbine seals, volume 1. [for turbofan engines

NASA Technical Reports Server (NTRS)

Sundberg, D. V.; Dennis, R. E.; Hurst, L. G.

1979-01-01

The application and advantages of abradable coatings as gas-path seals in a general aviation turbine engine were evaluated for use on the high-pressure compressor, the high-pressure turbine, and the low-pressure turbine shrouds. Topics covered include: (1) the initial selection of candidate materials for interim full-scale engine testing; (2) interim engine testing of the initially selected materials and additional candidate materials; (3) the design of the component required to adapt the hardware to permit full-scale engine testing of the most promising materials; (4) finalization of the fabrication methods used in the manufacture of engine test hardware; and (5) the manufacture of the hardware necessary to support the final full-scale engine tests.

Adjustable Autonomy and Human-Agent Teamwork in Practice: An Interim Report on Space Applications

NASA Technical Reports Server (NTRS)

Bradshaw, Jeffrey M.; Feltovich, Paul; Hoffman, Robert; Jeffers, Renia; Suri, Niranhan; Uszok, Andrzej; VanHoof, Ron; Acquisti, Alessandro; Prescott, Debbie

2003-01-01

We give a preliminary perspective on the basic principles and pitfalls of adjustable autonomy and human-centered teamwork. We then summarize the interim results of our study on the problem of work practice modeling and human-agent collaboration in space applications, the development of a broad model of human-agent teamwork grounded in practice, and the integration of the Brahms, KAoS, and NOMADS agent frameworks. We hope our work will benefit those who plan and participate in work activities in a wide variety of space applications, as well as those who are interested in design and execution tools for teams of robots that can function as effective assistants to humans.

43 CFR 3809.201 - What should these agreements address?

Code of Federal Regulations, 2013 CFR

2013-10-01

.... Operations must not begin until BLM completes consultation or conferencing under the Endangered Species Act. ... whether Federally proposed or listed threatened or endangered species or their proposed or designated... Policy Act; performance standards; interim management of temporary closure; financial guarantees...

43 CFR 3809.201 - What should these agreements address?

Code of Federal Regulations, 2012 CFR

2012-10-01

.... Operations must not begin until BLM completes consultation or conferencing under the Endangered Species Act. ... whether Federally proposed or listed threatened or endangered species or their proposed or designated... Policy Act; performance standards; interim management of temporary closure; financial guarantees...

43 CFR 3809.201 - What should these agreements address?

Code of Federal Regulations, 2014 CFR

2014-10-01

.... Operations must not begin until BLM completes consultation or conferencing under the Endangered Species Act. ... whether Federally proposed or listed threatened or endangered species or their proposed or designated... Policy Act; performance standards; interim management of temporary closure; financial guarantees...

Interim Conclusions, Recommendations, and Design Guidelines for Durability of Post-Tensioned Bridge Substructures

DOT National Transportation Integrated Search

1999-10-01

The use of post-tensioning in bridges can provide durability and structural benefits to the system while expediting the construction process. When post-tensioning is combined with precast elements, traffic interference can be greatly reduced through ...

Mobile satellite service for Canada

NASA Technical Reports Server (NTRS)

Sward, David

1988-01-01

The Mobile Satellite (MSAT) system and a special program designed to provide interim mobile satellite services (IMSS) during the construction phase of MSAT are described. A mobile satellite system is a key element in extending voice and and data telecommunications to all Canadians.

MEPDG Traffic Loading Defaults Derived from Traffic Pooled Fund Study

DOT National Transportation Integrated Search

2016-04-01

As part of traffic loading inputs, the Mechanistic-Empirical Pavement Design Guide (MEPDG), Interim Edition: A Manual of Practice requires detailed axle loading information in the form of normalized axle load spectra (NALS), number of axle per truck ...

Proof of concept deployment plan.

DOT National Transportation Integrated Search

2008-02-01

The U.S. Department of Transportation (USDOT) Next Generation 9-1-1 (NG9-1-1) : Proof-of-Concept (POC) demonstration is envisioned to test key features and : functionalities of the NG9-1-1 system. The Interim POC System Design Document : defines the ...

40 CFR 93.119 - Criteria and procedures: Interim emissions in areas without motor vehicle emissions budgets.

Code of Federal Regulations, 2010 CFR

2010-07-01

... emissions analysis as listed in § 93.127 need not be explicitly considered): (1) All in-place regionally... must include the project with its original design concept and scope, and the ‘Action’ scenario must include the project with its new design concept and scope. [62 FR 43801, Aug. 15, 1997, as amended at 69...

Hybrid Wing-Body (HWB) Pressurized Fuselage Modeling, Analysis, and Design for Weight Reduction

NASA Technical Reports Server (NTRS)

Mukhopadhyay, Vivek

2012-01-01

This paper describes the interim progress for an in-house study that is directed toward innovative structural analysis and design of next-generation advanced aircraft concepts, such as the Hybrid Wing-Body (HWB) and the Advanced Mobility Concept-X flight vehicles, for structural weight reduction and associated performance enhancement. Unlike the conventional, skin-stringer-frame construction for a cylindrical fuselage, the box-type pressurized fuselage panels in the HWB undergo significant deformation of the outer aerodynamic surfaces, which must be minimized without significant structural weight penalty. Simple beam and orthotropic plate theory is first considered for sizing, analytical verification, and possible equivalent-plate analysis with appropriate simplification. By designing advanced composite stiffened-shell configurations, significant weight reduction may be possible compared with the sandwich and ribbed-shell structural concepts that have been studied previously. The study involves independent analysis of the advanced composite structural concepts that are presently being developed by The Boeing Company for pressurized HWB flight vehicles. High-fidelity parametric finite-element models of test coupons, panels, and multibay fuselage sections, were developed for conducting design studies and identifying critical areas of potential failure. Interim results are discussed to assess the overall weight/strength advantages.

Internal pilots for a class of linear mixed models with Gaussian and compound symmetric data

PubMed Central

Gurka, Matthew J.; Coffey, Christopher S.; Muller, Keith E.

2015-01-01

SUMMARY An internal pilot design uses interim sample size analysis, without interim data analysis, to adjust the final number of observations. The approach helps to choose a sample size sufficiently large (to achieve the statistical power desired), but not too large (which would waste money and time). We report on recent research in cerebral vascular tortuosity (curvature in three dimensions) which would benefit greatly from internal pilots due to uncertainty in the parameters of the covariance matrix used for study planning. Unfortunately, observations correlated across the four regions of the brain and small sample sizes preclude using existing methods. However, as in a wide range of medical imaging studies, tortuosity data have no missing or mistimed data, a factorial within-subject design, the same between-subject design for all responses, and a Gaussian distribution with compound symmetry. For such restricted models, we extend exact, small sample univariate methods for internal pilots to linear mixed models with any between-subject design (not just two groups). Planning a new tortuosity study illustrates how the new methods help to avoid sample sizes that are too small or too large while still controlling the type I error rate. PMID:17318914

Alternative Models for Individualized Armor Training. Part I. Interim Report: Review and Analysis of the Literature

DTIC Science & Technology

1980-01-01

for an individualized instructional con- text is provided by Giordono (1975), in his discussion of the design of a " non - lockstep educational system...state of ATI research, sum- marized the methodological and theoretical problems that may have inhibited the application of ATI findings to the design ...years. In contrast, systematic modifications based on results obtained through the application of appropriate experimental designs are desired and

Overview of Engineering Design and Analysis at the NASA John C. Stennis Space Center

NASA Technical Reports Server (NTRS)

Congiardo, Jared; Junell, Justin; Kirkpatrick, Richard; Ryan, Harry

2007-01-01

This viewgraph presentation gives a general overview of the design and analysis division of NASA John C. Stennis Space Center. This division develops and maintains propulsion test systems and facilities for engineering competencies.

5 CFR 772.102 - Interim personnel actions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Interim personnel actions. 772.102 Section 772.102 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) INTERIM RELIEF General § 772.102 Interim personnel actions. When an employee or...

5 CFR 772.102 - Interim personnel actions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Interim personnel actions. 772.102 Section 772.102 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) INTERIM RELIEF General § 772.102 Interim personnel actions. When an employee or...

Effect of salt additives on concrete degradation : interim report

DOT National Transportation Integrated Search

1993-06-01

Many chemical additives designed to inhibit the corrosive effect of salt on rebars are being marketed. Their effect on Portland Cement Concrete is neither known nor understood. This study is an attempt to determine if there is an effect and to unders...

Southern California ITS Priority Corridor strategic deployment plan : interim report

DOT National Transportation Integrated Search

1998-08-01

This deployment plan will be the "blueprint" for agencies to follow to ensure that projects are designed and built to conform to the National ITS Architecture and Standards, a requirement for funding under TEA 21. The federal ITS planning and deploym...

40 CFR 745.83 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... with none of the air leaking past it. Interim controls means a set of measures designed to temporarily... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED... disposable cleaning cloths with the card, whether post-renovation cleaning has been properly completed...

40 CFR 745.83 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... with none of the air leaking past it. Interim controls means a set of measures designed to temporarily... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED... disposable cleaning cloths with the card, whether post-renovation cleaning has been properly completed...

Interim Evaluation of Three Instrumented Bridge Decks in Saco, Montana

DOT National Transportation Integrated Search

2006-06-01

Since the service life of concrete bridge decks designed by traditional procedures is often shorter than desired, : their ability to withstand constant and heavy use in a variety of operating environments is of major concern. In : this project, the r...

Evaluation of experimental flexible pavements : interim report no. 1, construction of Altavista Bypass experimental pavement.

DOT National Transportation Integrated Search

1974-01-01

Deflection tests conducted during the construction and shortly after the completion of a large experimental pavement project are reported. Four different pavement designs, as follows, are compared: 1. 6-inch cement stabilized subgrade, 6-inch crushed...

Rural applications of advanced traveler information systems : user needs and technology assessment

DOT National Transportation Integrated Search

1997-07-01

The User Needs and Technology Assessment Report is one in a series of interim documents for the Rural Applications of Advanced Traveler Information Systems (ATIS) project. The document describes the research design and findings from rural traveler su...

Interim Expertise

ERIC Educational Resources Information Center

Anyaso, Hilary Hurd

2009-01-01

The Registry for College and University Presidents places former executives in interim presidential and other senior-level posts and is familiar with the challenges interim executives and institutions encounter in times of leadership transitions. However, the one big advantage interims bring to institutions, says Registry Vice President Kevin J.…

40 CFR 155.56 - Interim registration review decision.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Interim registration review decision... PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures § 155.56 Interim registration review decision. The Agency may issue, when it determines it to be appropriate, an interim...

21 CFR 5.1100 - Headquarters.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., and Social Sciences. Regulations and Special Government Employees Management Staff. Division of Social... and Management Staff. Good Clinical Practice Staff. Office of Combination Products. Office of Orphan... Branch. Division of Communication Media. Television Design and Development Branch. Division of Freedom of...

21 CFR 5.1100 - Headquarters.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., and Social Sciences. Regulations and Special Government Employees Management Staff. Division of Social... and Management Staff. Good Clinical Practice Staff. Office of Combination Products. Office of Orphan... Branch. Division of Communication Media. Television Design and Development Branch. Division of Freedom of...

21 CFR 5.1100 - Headquarters.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., and Social Sciences. Regulations and Special Government Employees Management Staff. Division of Social... and Management Staff. Good Clinical Practice Staff. Office of Combination Products. Office of Orphan... Branch. Division of Communication Media. Television Design and Development Branch. Division of Freedom of...

17 CFR 210.8-03 - Interim financial statements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (§ 249.308(a) of this chapter) must be reviewed by an independent public accountant using professional... interim financial statements have been reviewed by an independent public accountant, a report of the accountant on the review must be filed with the interim financial statements. Interim financial statements...

24 CFR 35.1330 - Interim controls.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Interim controls. 35.1330 Section... Lead-Paint Hazard Evaluation and Hazard Reduction Activities § 35.1330 Interim controls. Interim controls of lead-based paint hazards identified in a risk assessment shall be conducted in accordance with...

7 CFR 1738.21 - Interim financing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Interim financing. 1738.21 Section 1738.21... Interim financing. (a) Upon notification by RUS that an applicant's application is considered complete, the applicant may enter into an interim financing agreement with a lender other than RUS or use its...

A design study to develop young children's understanding of multiplication and division

NASA Astrophysics Data System (ADS)

Bicknell, Brenda; Young-Loveridge, Jenny; Nguyen, Nhung

2016-12-01

This design study investigated the use of multiplication and division problems to help 5-year-old children develop an early understanding of multiplication and division. One teacher and her class of 15 5-year-old children were involved in a collaborative partnership with the researchers. The design study was conducted over two 4-week periods in May-June and October-November. The focus in this article is on three key aspects of classroom teaching: instructional tasks, the use of representations, and discourse, including the mathematics register. Results from selected pre- and post-assessment tasks within a diagnostic interview showed that there were improvements in addition and subtraction as well as multiplication and division, even though the teaching had used multiplication and division problems. Students made progress on all four operational domains, with effect sizes ranging from approximately two thirds of a standard deviation to 2 standard deviations. Most of the improvement in students' number strategies was in moving from `counting all' to `counting on' and `skip counting'. The findings challenge the idea that learning experiences in addition and subtraction should precede those in multiplication and division as suggested in some curriculum documents.

75 FR 10319 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

...,058C; Cadence Design Systems, Inc., Custom Integrated Circuit Design, West Valley, Austin, TX May 18...., Silicon Package Board (SPB) Division, Austin, TX. May 18, 2008 TA-W-70,058Q; Cadence Design Systems, Inc... Systems, Inc., Global Customer Support (GCS) Division, Austin, TX May 18, 2008 TA-W-70,058V; Cadence...

An Interim Report of the Evaluation of a Comprehensive High School Civic Engagement Intervention in Hudson, MA. CIRCLE Working Paper 58

ERIC Educational Resources Information Center

McIntosh, Hugh; Berman, Sheldon H.; Youniss, James

2007-01-01

In September 2003, Hudson High School in Hudson, Massachusetts launched two new civic development efforts--clustering and schoolwide governance--and moved into a new building designed to facilitate them. Clustering is designed to achieve a sense of community within a large school by creating small communities of 100 to 150 students. To create…

An Approach for Evaluating the Technical Quality of Interim Assessments

ERIC Educational Resources Information Center

Li, Ying; Marion, Scott; Perie, Marianne; Gong, Brian

2010-01-01

Increasing numbers of schools and districts have expressed interest in interim assessment systems to prepare for summative assessments and to improve teaching and learning. However, with so many commercial interim assessments available, schools and districts are struggling to determine which interim assessment is most appropriate to their needs.…

47 CFR 51.611 - Interim wholesale rates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... selecting a particular discount rate. The same discount percentage rate shall be used to establish interim... 47 Telecommunication 3 2010-10-01 2010-10-01 false Interim wholesale rates. 51.611 Section 51.611... Resale § 51.611 Interim wholesale rates. (a) If a state commission cannot, based on the information...

7 CFR 15a.71 - Interim procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Interim procedures. 15a.71 Section 15a.71 Agriculture Office of the Secretary of Agriculture EDUCATION PROGRAMS OR ACTIVITIES RECEIVING OR BENEFITTING FROM FEDERAL FINANCIAL ASSISTANCE Procedures (Interim) § 15a.71 Interim procedures. For the purposes of...

77 FR 55230 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2012-01; Compliance With...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-07

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0068] Japan Lessons-Learned Project Directorate Interim... Commission (NRC). ACTION: Japan Lessons-Learned Project Directorate interim staff guidance; issuance. SUMMARY...-Learned Project Directorate Interim Staff Guidance (JLD-ISG), JLD-ISG-2012-01, ``Compliance with Order EA...

77 FR 55231 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2012-02; Compliance With...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-07

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0069] Japan Lessons-Learned Project Directorate Interim...-Learned Project Directorate interim staff guidance; issuance. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or the Commission) is issuing the Final Japan Lessons-Learned Project Directorate Interim...

7 CFR 1735.75 - Interim financing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Interim financing. 1735.75 Section 1735.75... Involving Loan Funds § 1735.75 Interim financing. (a) A borrower may submit a written request for RUS approval of interim financing if it is necessary to close an acquisition before the loan to finance the...

13 CFR 120.890 - Source of interim financing.

Code of Federal Regulations, 2014 CFR

2014-01-01

....890 Section 120.890 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Interim Financing § 120.890 Source of interim financing. A Project may... experience or qualifications, SBA may require the interim loan to be managed by a third party such as a bank...

13 CFR 120.890 - Source of interim financing.

Code of Federal Regulations, 2010 CFR

2010-01-01

....890 Section 120.890 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Interim Financing § 120.890 Source of interim financing. A Project may... experience or qualifications, SBA may require the interim loan to be managed by a third party such as a bank...

13 CFR 120.890 - Source of interim financing.

Code of Federal Regulations, 2013 CFR

2013-01-01

....890 Section 120.890 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Interim Financing § 120.890 Source of interim financing. A Project may... experience or qualifications, SBA may require the interim loan to be managed by a third party such as a bank...

13 CFR 120.890 - Source of interim financing.

Code of Federal Regulations, 2012 CFR

2012-01-01

....890 Section 120.890 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Interim Financing § 120.890 Source of interim financing. A Project may... experience or qualifications, SBA may require the interim loan to be managed by a third party such as a bank...

13 CFR 120.890 - Source of interim financing.

Code of Federal Regulations, 2011 CFR

2011-01-01

....890 Section 120.890 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Interim Financing § 120.890 Source of interim financing. A Project may... experience or qualifications, SBA may require the interim loan to be managed by a third party such as a bank...

Full Service ISDN Satellite (FSIS) network model for advanced ISDN satellite design and experiments

NASA Technical Reports Server (NTRS)

Pepin, Gerard R.

1992-01-01

The Full Service Integrated Services Digital Network (FSIS) network model for advanced satellite designs describes a model suitable for discrete event simulations. A top down model design uses the Advanced Communications Technology Satellite (ACTS) as its basis. The ACTS and the Interim Service ISDN Satellite (ISIS) perform ISDN protocol analyses and switching decisions in the terrestrial domain, whereas FSIS makes all its analyses and decisions on-board the ISDN satellite.

Aeromedical Airlift -- Do the Pieces Fit?

DTIC Science & Technology

1988-01-01

architecture analysis. feasibility study, and system design phase. To save money and time associated with unforeseen down-line modifications that may... loand Redietribution of Patients in CONUS. Draft Interim; Report No. IX-h. Maximnus, Inc., McLean Va.: Prepared for Office of the Assistant.Secretary of

40 CFR 52.134 - Compliance schedules.

Code of Federal Regulations, 2013 CFR

2013-07-01

... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

40 CFR 52.134 - Compliance schedules.

Code of Federal Regulations, 2010 CFR

2010-07-01

... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

40 CFR 52.134 - Compliance schedules.

Code of Federal Regulations, 2012 CFR

2012-07-01

... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

40 CFR 52.134 - Compliance schedules.

Code of Federal Regulations, 2014 CFR

2014-07-01

... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

40 CFR 52.134 - Compliance schedules.

Code of Federal Regulations, 2011 CFR

2011-07-01

... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

Field study of a glass-reinforced plastic pedestrian bridge : interim report.

DOT National Transportation Integrated Search

1977-01-01

Discussed are the design, fabrication, and load testing of girders composed entirely of glass-reinforced polyester (GRP) resin. The girders were 4.9 m (16 ft.) long and had geometric features which included trussed webs, a solid flange plate, and a t...

DEVELOPMENT OF DIES FOR EXTRUSION OF COMPLEX SHAPES OF STEEL AND REFRACTORY ALLOYS. Interim Technical Documentary Progress Report to Aeronautical Systems Division for the Period September 16,1962 through December 31, 1962

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunt, J.G.; Jenkins, R.G.; White, A.M.

1963-03-01

A number of ceramics, metallic compounds, and ceramic-metal composites were successfully hot pressed into the shape of die inserts. Steels were extruded through several of these for the purpose of evaluating the materials or to study methods of supporting the die inserts. Refractory metal inserts were also used in similar tests. Hot pressed inserts consisting of 80 vo1% Al/sub 2/O/ sub 3/--10 vol% W and 80 vol% ThO/sub 2/--10 vol% W cracked but did not erode. Sintered molybdenum inserts flowed excessively, whereas sintered tungsten inserts flowed to a lesser degree. A hard die casing with a slight shrink fit appearsmore » to be the most satisfactory method of support. (auth)« less

Navajo coal and air quality in Shiprock, New Mexico

USGS Publications Warehouse

Bunnell, Joseph E.; Garcia, Linda V.

2006-01-01

Among the Navajo people, high levels of respiratory disease, such as asthma, exist in a population with low rates of cigarette smoking. Air quality outdoors and indoors affects respiratory health. Many Navajo Nation residents burn locally mined coal in their homes for heat, as coal is the most economical energy source. The U.S. Geological Survey and Dine College, in cooperation with the Navajo Division of Health, are conducting a study in the Shiprock, New Mexico, area to determine if indoor use of this coal might be contributing to some of the respiratory health problems experienced by the residents. Researchers in this study will (1) examine respiratory health data, (2) identify stove type and use, (3) analyze samples of coal that are used locally, and (4) measure and characterize air quality inside selected homes. This Fact Sheet summarizes the interim results of the study in both English and Navajo.

ECS - The European Communication Satellite system

NASA Astrophysics Data System (ADS)

Wooster, C. B.

1981-09-01

The evolution of the European Communication Satellite system (ECS) is traced from feasibility studies in 1970 to the development and launch in 1978 of the Orbital Test Satellite (OTS) by the European Space Agency to prove the new satellite and radio transmission technology being used on ECS. This was followed by the establishment of 'Interim EUTELSAT' in 1979 as the organization to operate ECS. The satellite, which operates at 11/14 GHz, covers all the capitals in Europe via three spot beam antennas, supplemented by a 'Eurobeam' regional coverage antenna which extends the range to cover all of Europe and the Mediterranean basin. Telephony channels are transmitted digitally using time division multiple access (TDMA) with digital speech interpolation (DSI) to optimize satellite capacity. Television transmission is by analog FM over the Eurobeam antenna to North African as well as European capitals. System implications of TDMA operation are discussed, and the EUTELSAT policy for Special Services or satellite business systems is discussed.

High Energy Physics

Science.gov Websites

Untitled Document [Argonne Logo] [DOE Logo] High Energy Physics Home Division ES&H Personnel Collider Physics Cosmic Frontier Cosmic Frontier Theory & Computing Detector R&D Electronic Design Mechanical Design Neutrino Physics Theoretical Physics Seminars HEP Division Seminar HEP Lunch Seminar HEP

12 CFR 552.2-2 - Procedures for organization of interim Federal stock association.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Procedures for organization of interim Federal stock association. (a) Applications for permission to organize... chapter or § 552.2-1(b)(3) of this part. (b) Approval of an application for permission to organize an... the interim was chartered to facilitate. Applications for permission to organize an interim Federal...

Interpretation of the Ecological Significance of Atrazine Stream-Water Concentrations Using a Statistically-Designed Monitoring Program

EPA Science Inventory

A risk assessment was conducted by the US Environmental Protection Agency (EPA) as part of the 2003 Interim Registration Eligibility Document (IRED) on atrazine. The assessment indicated potential community- and population-level risk to sensitive aquatic ecosystems at prolonged ...

Field trial of gravel stabilization methods : Route 1, Cyr-Van Buren, ME : 2nd interim report.

DOT National Transportation Integrated Search

1995-02-01

This experimental construction project was developed, designed, and inspected by personnel from the University of Maine, Civil Engineering Staff. The experimental project was constructed on and as a part of Project #2586 00. This was a complete recon...

Field trial of gravel stabilization methods : Route 1, Cyr-Van Buren, ME : 1st interim report.

DOT National Transportation Integrated Search

1993-05-01

This experimental construction project was developed, designed, and inspected by personnel from the University of Maine, Civil Engineering Staff. The experimental project was constructed on and as a part of Project #2586.00. This was a complete recon...

Utilizing Snap-Tite slip line pipe as a direct burial cross pipe, construction and first interim report, October, 2007.

DOT National Transportation Integrated Search

2007-10-01

The Maine Department of Transportation uses reinforced concrete, polymer coated corrugated metal, : corrugated aluminum or corrugated polyethylene for highway cross pipes. Design life for cross pipe is 50 : plus years. Repair of failed cross pipes in...

14 CFR 171.263 - Localizer automatic monitor system.

Code of Federal Regulations, 2012 CFR

2012-01-01

... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing... provide an automatic monitor system that transmits a warning to designated local and remote control points... centerline equivalent to more than 0.015 DDM at the ISMLS reference datum. (2) For localizers in which the...

14 CFR 171.263 - Localizer automatic monitor system.

Code of Federal Regulations, 2014 CFR

2014-01-01

... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing... provide an automatic monitor system that transmits a warning to designated local and remote control points... centerline equivalent to more than 0.015 DDM at the ISMLS reference datum. (2) For localizers in which the...

14 CFR 171.263 - Localizer automatic monitor system.

Code of Federal Regulations, 2010 CFR

2010-01-01

... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing... provide an automatic monitor system that transmits a warning to designated local and remote control points... centerline equivalent to more than 0.015 DDM at the ISMLS reference datum. (2) For localizers in which the...

14 CFR 171.263 - Localizer automatic monitor system.

Code of Federal Regulations, 2011 CFR

2011-01-01

... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing... provide an automatic monitor system that transmits a warning to designated local and remote control points... centerline equivalent to more than 0.015 DDM at the ISMLS reference datum. (2) For localizers in which the...

14 CFR 171.263 - Localizer automatic monitor system.

Code of Federal Regulations, 2013 CFR

2013-01-01

... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing... provide an automatic monitor system that transmits a warning to designated local and remote control points... centerline equivalent to more than 0.015 DDM at the ISMLS reference datum. (2) For localizers in which the...

Fatigue and shear behavior of HPC bulb-tee girders : interim report.

DOT National Transportation Integrated Search

2003-10-01

Three 96-ft (29.3-m) long, 72-in. (1.83-m) deep, precast, pretensioned bulb-tee girders were tested to evaluate behavior under flexural fatigue and static shear loadings. The three girders had a design concrete compressive strength of 10,000 psi (69....

76 FR 14559 - Federal Acquisition Regulation; Justification and Approval of Sole-Source 8(a) Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-16

... Space Administration (NASA). ACTION: Interim rule. SUMMARY: DoD, GSA, and NASA are issuing an interim..., and NASA are issuing an interim rule amending the FAR, to implement section 811 of the National... meetings, DoD, GSA, and NASA weighed the costs and benefits of publishing this rule as proposed or interim...

Interim Administrators in Higher Education: A National Study

ERIC Educational Resources Information Center

Huff, Marie Thielke; Neubrander, Judy

2015-01-01

The focus of this paper is on the roles and experiences of interim administrators in higher education. A survey was given to current and recent interim administrators in four-year public universities and colleges across the United States. The goals were to identify the advantages and disadvantages of using and serving as interims, and to solicit…

Design and implementation of a Windows NT network to support CNC activities

NASA Technical Reports Server (NTRS)

Shearrow, C. A.

1996-01-01

The Manufacturing, Materials, & Processes Technology Division is undergoing dramatic changes to bring it's manufacturing practices current with today's technological revolution. The Division is developing Computer Automated Design and Computer Automated Manufacturing (CAD/CAM) abilities. The development of resource tracking is underway in the form of an accounting software package called Infisy. These two efforts will bring the division into the 1980's in relationship to manufacturing processes. Computer Integrated Manufacturing (CIM) is the final phase of change to be implemented. This document is a qualitative study and application of a CIM application capable of finishing the changes necessary to bring the manufacturing practices into the 1990's. The documentation provided in this qualitative research effort includes discovery of the current status of manufacturing in the Manufacturing, Materials, & Processes Technology Division including the software, hardware, network and mode of operation. The proposed direction of research included a network design, computers to be used, software to be used, machine to computer connections, estimate a timeline for implementation, and a cost estimate. Recommendation for the division's improvement include action to be taken, software to utilize, and computer configurations.

A Systems Analysis of the Library and Information Science Statistical Data System: The Preliminary Study. Interim Report.

ERIC Educational Resources Information Center

Hamburg, Morris; And Others

The long-term goal of this investigation is to design and establish a national model for a system of library statistical data. This is a report on The Preliminary Study which was carried out over an 11-month period ending May, 1969. The objective of The Preliminary Study was to design and delimit The Research Investigation in the most efficient…

Scenarios and performance measures for advanced ISDN satellite design and experiments

NASA Technical Reports Server (NTRS)

Pepin, Gerard R.

1991-01-01

Described here are the contemplated input and expected output for the Interim Service Integrated Services Digital Network (ISDN) Satellite (ISIS) and Full Service ISDN Satellite (FSIS) Models. The discrete event simulations of these models are presented with specific scenarios that stress ISDN satellite parameters. Performance measure criteria are presented for evaluating the advanced ISDN communication satellite designs of the NASA Satellite Communications Research (SCAR) Program.

Panasonic Small Cell Testing for AHPS

NASA Technical Reports Server (NTRS)

Pearson, C.; Blackmore, P.; Lain, M.; Walpole, A.; Darcy, Eric

2006-01-01

AEA selection and successful Interim Design Review for AHPS proves maturity of small cell approach for very large batteries. Cells show excellent opportunity for battery mass reduction for AHPS and other low cycle applications. Lack of cycle and extended calendar life make EOL battery performance difficult (AHPS 8 year mission). Preliminary design, AEA retained SONY 18650HC cell as baseline: a) Well characterized performance; b) Wealth of safety test data.

Fostering community understanding of sufficient benefit and early stopping for a phase 2B HIV prevention clinical trial in Africa.

PubMed

White, Rhonda; Chileshe, Modesta; Dawson, Liza; Donnell, Deborah; Hillier, Sharon; Morar, Neetha; Noguchi, Lisa; Dixon, Dennis

2011-02-01

Most trials of interventions are designed to address the traditional null hypothesis of no benefit. VOICE, a phase 2B HIV prevention trial funded by NIH and conducted in Africa, is designed to assess if the intervention will prevent a substantial fraction of infections. Planned interim analysis may provide conclusive evidence against the traditional null hypothesis without establishing substantial benefit. At this interim point, the Data and Safety Monitoring Board would then face the dilemma of knowing the product has some positive effect, but perhaps not as great an effect as the protocol has declared necessary. In March 2008, NIH program staff recommended that the VOICE protocol team discuss the stopping rules with stakeholders prior to initiating the protocol. The goals of the workshop were to inform community representatives about the potential ethical dilemma associated with stopping rules and engage in dialogue about these issues. We describe the resulting community consultation and summarize the outcomes. A 2-day workshop was convened with the goal of having a clear and transparent consultation with the stakeholders around the question, 'Given emerging evidence that a product could prevent some infections, would the community support a decision to continue accruing to the trial?' Participants included research staff and community stakeholders. Lectures with visual aids, discussions, and exercises using interactive learning tasks were used, with a focus on statistics and interpreting data from trials, particularly interim data. Results of oral and written evaluations by participants were reviewed. The feedback was mostly positive, with some residual confusion regarding statistical concepts. However, discussions with attendees later revealed that not all felt prepared to engage fully in the workshop. This was the presenters' first experience facilitating a formal discussion with an audience that had no advanced science, research, or mathematics training. Community representatives' concern regarding speaking for their communities without consulting them also created a challenge for the workshop. Open discussion around trial stopping rules requires that all discussants have an understanding of trial design concepts and feel a sense of empowerment to ask and answer questions. The VOICE CWG workshop was a first step toward the goal of open discussion regarding trial stopping rules and interim results for the study; however, ongoing education and dialogue must occur to ensure that all stakeholders fully participate in the process.

Wide Field Infrared Survey Telescope [WFIRST]: Telescope Design and Simulated Performance

NASA Technical Reports Server (NTRS)

Goullioud, R.; Content, D. A.; Kuan, G. M.; Moore, J. D.; Chang, Z.; Sunada, E. T.; Villalvazo, J.; Hawk, J. P.; Armani, N. V.; Johnson, E. L.;

LINER FOR EXTRUSION BILLET CONTAINERS. Interim Technical Documentary Progress Report, June 5, 1962-September 5, 1962

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spachner, S.A.

1962-10-31

A container-sleeve-liner assembly was designed which will provide adequate support for ceramic, ceramic coated metal, or metal liners. The design minimizes mechanical property requirements of liner materials, and permits rapid removal of worn or damaged liners. A high-strength stem was designed and fabricated. Technical literature on high-strength materials was reviewed, and high-strength materials producers were contacted to locate sources and assess applicability of existing materials for refractory metal extrusion liner use. (auth)

Application of Lanczos vectors to control design of flexible structures, part 2

NASA Technical Reports Server (NTRS)

Craig, Roy R., Jr.; Su, Tzu-Jeng

1992-01-01

This report covers the period of the grant from January 1991 until its expiration in June 1992. Together with an Interim Report (Ref. 9), it summarizes the research conducted under NASA Grant NAG9-357 on the topic 'Application of Lanczos Vectors to Control Design of Flexible Structures.' The research concerns various ways to obtain reduced-order mathematical models of complex structures for use in dynamics analysis and in the design of control systems for these structures. This report summarizes the research.

76 FR 10395 - BreconRidge Manufacturing Solutions, Now Known as Sanmina-SCI Corporation, Division...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

... Solutions, Now Known as Sanmina-SCI Corporation, Division Optoelectronic and Microelectronic Design and Manufacturing, a Subsidiary of Sanmina-SCI Corporation, Including On- Site Leased Workers From Kelly Services... Manufacturing Solutions, now known as Sanmina-SCI Corporation, Division Optoelectronic and Microelectronic...

Design and Implementation of Instructional Videos for Upper-Division Undergraduate Laboratory Courses

ERIC Educational Resources Information Center

Schmidt-McCormack, Jennifer A.; Muniz, Marc N.; Keuter, Ellie C.; Shaw, Scott K.; Cole, Renée S.

2017-01-01

Well-designed laboratories can help students master content and science practices by successfully completing the laboratory experiments. Upper-division chemistry laboratory courses often present special challenges for instruction due to the instrument intensive nature of the experiments. To address these challenges, particularly those associated…

Near Field HF Antenna Pattern Measurement Method Using an Antenna Pattern Range

DTIC Science & Technology

2015-12-01

Year 2015 by the Applied Electromagnetics Branch (Code 52250) of the System of Systems (SoS) & Platform Design Division (Code 52200), Space and...Head SoS & Platform Design Division iii EXECUTIVE SUMMARY The Antenna Pattern Range (APR) is an essential measurement facility operated at Space...14 1 INTRODUCTION Accurate characterization of antennas designed to support the warfighter is a critical

Biomechanical and Performance Differences Between Female Soccer Athletes in National Collegiate Athletic Association Divisions I and III

PubMed Central

Smith, Rose; Ford, Kevin R; Myer, Gregory D; Holleran, Adam; Treadway, Erin; Hewett, Timothy E

2007-01-01

Context: The recent increase in women's varsity soccer participation has been accompanied by a lower extremity injury rate that is 2 to 6 times that of their male counterparts. Objective: To define the differences between lower extremity biomechanics (knee abduction and knee flexion measures) and performance (maximal vertical jump height) between National Collegiate Athletic Association Division I and III female soccer athletes during a drop vertical jump. Design: Mixed 2 × 2 design. Setting: Research laboratory. Patients or Other Participants: Thirty-four female collegiate soccer players (Division I: n = 19; Division III: n = 15) participated in the study. The groups were similar in height and mass. Intervention(s): Each subject performed a maximal vertical jump, followed by 3 drop vertical jumps. Main Outcome Measure(s): Kinematics (knee abduction and flexion angles) and kinetics (knee abduction and flexion moments) were measured with a motion analysis system and 2 force platforms during the drop vertical jumps. Results: Knee abduction angular range of motion and knee abduction external moments were not different between groups (P > .05). However, Division I athletes demonstrated decreased knee flexion range of motion (P = .038) and greater peak external knee flexion moment (P = .009) compared with Division III athletes. Division I athletes demonstrated increased vertical jump height compared with Division III (P = .008). Conclusions: Division I athletes demonstrated different sagittal-plane mechanics than Division III athletes, which may facilitate improved performance. The similarities in anterior cruciate ligament injury risk factors (knee abduction torques and angles) may correlate with the consistent incidence of anterior cruciate ligament injury across divisions. PMID:18174935

Interim estimates of the effectiveness of the influenza vaccine against A(H3N2) influenza in adults in South Korea, 2016-2017 season.

PubMed

Noh, Ji Yun; Lim, Sooyeon; Song, Joon Young; Choi, Won Suk; Jeong, Hye Won; Heo, Jung Yeon; Lee, Jacob; Seo, Yu Bin; Lee, Jin-Soo; Wie, Seong Heon; Kim, Young Keun; Park, Kyung Hwa; Jung, Sook-In; Kim, Shin Woo; Lee, Sun Hee; Lee, Han Sol; Yoon, Young Hoon; Cheong, Hee Jin; Kim, Woo Joo

2017-01-01

In the 2016-2017 season, the A(H3N2) influenza epidemic presented an unusual early peak pattern compared with past seasons in South Korea. The interim vaccine effectiveness (VE) of influenza vaccination in preventing laboratory-confirmed influenza was estimated using test-negative design through the tertiary hospital-based influenza surveillance system in South Korea. From 1 September, 2016 to 7 January, 2017, adjusted VE of influenza vaccination in preventing laboratory-confirmed A(H3N2) was -52.1% (95% confidence interval [CI], -147.2 to 6.4); -70.0% (95% CI, -212.0 to 7.4) in 19-64 years and 4.3% (95% CI, -137.8 to 61.5) in the elderly. Circulating A(H3N2) viruses belonged to the three phylogenetic subclades of 3C.2a, differently to A/Hong Kong/4801/2014, the current vaccine strain. Amino acid substitutions in hemagglutinin of circulating viruses seem to contribute to low VE. In conclusion, interim VE analysis presented that the protection of laboratory-confirmed influenza by seasonal influenza vaccination did not show the statistical significance in South Korea in the 2016-2017 influenza season.

24 CFR 35.120 - Options.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Options. 35.120 Section 35.120... and Definitions for All Programs. § 35.120 Options. (a) Standard treatments. Where interim controls are required by this part, the designated party has the option to presume that lead-based paint or...

40 CFR 265.221 - Design and operating requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... effective date of a prohibition pursuant to § 268.5 of this chapter, within this 48-month period. [50 FR... (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... each replacement of an existing surface impoundment unit must install two or more liners, and a...

40 CFR 265.221 - Design and operating requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... effective date of a prohibition pursuant to § 268.5 of this chapter, within this 48-month period. [50 FR... (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... each replacement of an existing surface impoundment unit must install two or more liners, and a...

40 CFR 265.221 - Design and operating requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... effective date of a prohibition pursuant to § 268.5 of this chapter, within this 48-month period. [50 FR... (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... each replacement of an existing surface impoundment unit must install two or more liners, and a...

40 CFR 265.221 - Design and operating requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... effective date of a prohibition pursuant to § 268.5 of this chapter, within this 48-month period. [50 FR... (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... each replacement of an existing surface impoundment unit must install two or more liners, and a...

40 CFR 265.221 - Design and operating requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... effective date of a prohibition pursuant to § 268.5 of this chapter, within this 48-month period. [50 FR... (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... each replacement of an existing surface impoundment unit must install two or more liners, and a...

75 FR 34282 - Federal Acquisition Regulation; FAR Case 2009-014, New Designated Country-Taiwan

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

... Government Procurement. DATES: Effective Date: June 16, 2010. FOR FURTHER INFORMATION CONTACT: Ms. Lori... Government Procurement. The interim rule added Taiwan to the list of World Trade Organization Government... seq., because, although this rule opens up Government procurement to the goods and services of Taiwan...

An Intelligent CAI Monitor and Generative Tutor. Interim Report.

ERIC Educational Resources Information Center

Koffman, Elliot B.; And Others

Design techniques for generative computer-assisted-instructional (CAI) systems are described in this report. These are systems capable of generating problems for students and of deriving and monitoring solutions; problem difficulty, instructional pace, and depth of monitoring are all individually tailored and parts of the solution algorithms can…

The Challenges in Developing VET Competencies in E-Commerce.

ERIC Educational Resources Information Center

Mitchell, John

A formative evaluation was begun of an innovative project funded by the Australian National Training Authority (ANTA) to develop competencies and qualifications in e-commerce. The formative evaluation was designed to focus on inputs, processes, and interim outputs, identifying both good practice and areas for improvement. Findings to date…

40 CFR 265.51 - Purpose and implementation of contingency plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT... contingency plan must be designed to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents...

40 CFR 265.51 - Purpose and implementation of contingency plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT... contingency plan must be designed to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents...

40 CFR 265.51 - Purpose and implementation of contingency plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT... contingency plan must be designed to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents...

Futures in Business. Interim Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education and Training, Winnipeg.

This guide is designed for use by instructors teaching a six-unit course on futures in business. Presented first is a diagram illustrating the place of the course in Manitoba's business education curriculum. The academic, personal management, and teamwork skills that have been deemed critical employability skills required of the Canadian work…

School, Work and Family Planning. Interim Impacts in Project Redirection.

ERIC Educational Resources Information Center

Polit, Denise F.; And Others

Project Redirection was designed to help pregnant and parenting adolescents progress toward eventual self-sufficiency by linking them with community agencies and volunteers at four geographically and ethnically diverse sites in the United States. Distinctive features of the program include: (1) a broad scope of services including employability…

Physics 200, 300 Interim Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education, Winnipeg.

This guide, developed for the physics 200, 300 program in Manitoba, is designed to articulate with previous science courses; provide concepts, processes, and skills which will enable students to continue in physics-related areas; and relate physics to practical applications in everyday life. It includes a program overview (with program goals and…

77 FR 72683 - Sweet Cherries Grown in Designated Counties in Washington; Decreased Assessment Rate

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-06

... marketing order now in effect, Washington sweet cherry handlers are subject to assessments. Funds to... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 923 [Doc. No. AMS-FV-12-0026... AGENCY: Agricultural Marketing Service, USDA. ACTION: Interim rule with request for comments. SUMMARY...

Chemistry 200, 300 Interim Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education, Winnipeg.

This guide, developed for the chemistry 200, 300 program in Manitoba, is designed to articulate with previous science courses, provide concepts, processes, and skills which will enable students to continue in chemistry-related areas, and relate chemistry to practical applications in everyday life. It includes a program overview (with program goals…

77 FR 30002 - Primary Power, LLC v. PJM Interconnection, LLC; Notice of Complaint

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

... Respondent) for the Respondent's failure to designate the Complainant to construct, own, and finance two static VAR compensator (``SVC'') projects sponsored by the Complainant that have been included in the PJM Regional Transmission Expansion Plan. The Complainant requests that the Commission grant emergency, interim...

The National Study of Charter Management Organization (CMO) Effectiveness. Report on Interim Findings

ERIC Educational Resources Information Center

Lake, Robin; Dusseault, Brianna; Bowen, Melissa; Demeritt, Allison; Hill, Paul

2010-01-01

The National Study of CMO (charter management organizations) Effectiveness is a national, longitudinal research effort designed to measure how nonprofit charter school management organizations (CMOs) affect student achievement, and to examine the internal structures, practices, and policy contexts that may influence these outcomes. The study began…

78 FR 21520 - Sweet Cherries Grown in Designated Counties in Washington; Decreased Assessment Rate

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-11

... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 923 [Doc. No. AMS-FV-12-0026... AGENCY: Agricultural Marketing Service, USDA. ACTION: Affirmation of interim rule as final rule. SUMMARY... decreased the assessment rate established for the Washington Cherry Marketing Committee (Committee) for the...

Reading First Implementation Evaluation: Interim Report

ERIC Educational Resources Information Center

Moss, Marc; Jacob, Robin; Boulay, Beth; Horst, Megan; Poulos, Jennifer

2006-01-01

In October 2003, the US Department of Education contracted with Abt Associates to design and conduct the Reading First Implementation Evaluation. This report focuses on the following questions: (1) How is the Reading First program implemented in districts and schools? and (2) How does reading instruction differ in Reading First schools and…

Radon Reduction Techniques in Schools: Interim Technical Guidance.

ERIC Educational Resources Information Center

Environmental Protection Agency, Washington, DC.

This technical document is intended to assist school facilities maintenance personnel in the selection, design, and operation of radon reduction systems in schools. The guidance contained in this document is based largely on research conducted in 1987 and 1988 in schools located in Maryland and Virginia. Researchers from the United States…

78 FR 51138 - Partial Cancellation of Fremont Grain Inspection Department Inc. Designation; Selection of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

... to provide official inspection service through June 30, 2016, under the United States Grain Standards Act (USGSA), as amended. Fremont informed the Grain Inspection, Packers and Stockyards Administration... Service Company as the interim provider effective August 1, 2013 until a permanent designee is selected...

78 FR 21518 - Apricots Grown in Designated Counties in Washington; Decreased Assessment Rate

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-11

... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 922 [Doc. No. AMS-FV-12-0027...: Agricultural Marketing Service, USDA. ACTION: Affirmation of interim rule as final rule. SUMMARY: The... the assessment rate established for the Washington Apricot Marketing Committee (Committee) for the...

The Development of a Vocational Diagnostic Program. Interim Report.

ERIC Educational Resources Information Center

Barnard, William W.

A five-phased project is described which was designed to develop more specific diagnostic procedures and instrumentation that would allow both the vocational counselor and the prospective student to determine more effectively specific occupational programs and occupational objectives for education at the postsecondary level. Phases of the project…

CNN Newsroom Classroom Guides, February 2002.

ERIC Educational Resources Information Center

Cable News Network, Atlanta, GA.

These classroom guides, designed to accompany the daily CNN (Cable News Network) Newsroom broadcasts for the month of February 2002, provide program rundowns, suggestions for class activities and discussion, student handouts, and a list of related news terms. Top stories include: Afghanistan's interim leader is making a global impression (February…

Start Your Own Business. Interim Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education and Training, Winnipeg.

This guide is designed for use by instructors teaching a 12-unit course in starting a business. Presented first is a diagram illustrating the place of the course in Manitoba's business education curriculum. The academic, personal management, and teamwork skills that have been deemed critical employability skills required of the Canadian work force…

32 CFR 644.43 - Gross appraisals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... HANDBOOK Appraisal § 644.43 Gross appraisals. (a) Preparation. (1) The gross appraisal sections of real...-type or brief real estate design memoranda on civil works projects are submitted, comparable sales data... issued on the same project and if values have changed in the interim, additional sales data submitted to...

32 CFR 644.43 - Gross appraisals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... HANDBOOK Appraisal § 644.43 Gross appraisals. (a) Preparation. (1) The gross appraisal sections of real...-type or brief real estate design memoranda on civil works projects are submitted, comparable sales data... issued on the same project and if values have changed in the interim, additional sales data submitted to...

U.S. Metric Study Interim Report: Nonmanufacturing Businesses.

ERIC Educational Resources Information Center

National Bureau of Standards (DOC), Washington, DC.

This is the fifth in a series of reports from the U. S. Metric Study, conducted by the National Bureau of Standards, designed to cover the nonmanufacturing segment of the economy representing about 65 percent of the total U. S. employment: mining, agriculture, forestry, fisheries, construction, transportation, communications, utilities,…

78 FR 62963 - Apricots Grown in Designated Counties in Washington; Suspension of Handling Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-23

... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 922 [Doc. No. AMS-FV-13-0040... AGENCY: Agricultural Marketing Service, USDA. ACTION: Interim rule with request for comments. SUMMARY... under the Washington apricot marketing order (order) for the remainder of the 2013-2014 fiscal period...

Interim report on roughness measurement of elevated roadway sections : I-10 Laplace - Kenner, I-10 Henderson - Grosse Tete.

DOT National Transportation Integrated Search

1973-09-01

Two sections of Interstate 10 have been selected for study to determine the initial roughness and subsequent change in roughness with time. The two sections represent different design and construction procedures. : Section 1 is located on I-10 betwee...

77 FR 35652 - Approval and Promulgation of Implementation Plans and Designations of Areas for Air Quality...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-14

... Planning Branch, Air, Pesticides and Toxics Management Division, U.S. Environmental Protection Agency..., Regulatory Development Section, Air Planning Branch, Air, Pesticides and Toxics Management Division, U.S... Development Section, Air Planning Branch, Air, Pesticides and Toxics Management Division, U.S. Environmental...

76 FR 80777 - Approval and Promulgation of State Plans for Designated Facilities and Pollutants; State of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... Monitoring Branch, Air, Pesticides and Toxics Management Division, U.S. Environmental Protection Agency... Management Division, U.S. Environmental Protection Agency, Region 4, 61 Forsyth Street SW., Atlanta, Georgia..., Air, Pesticides and Toxics Management Division, U.S. Environmental Protection Agency, Region 4, 61...

28 CFR 0.65a - Litigation involving Environmental Protection Agency.

Code of Federal Regulations, 2010 CFR

2010-07-01

... DEPARTMENT OF JUSTICE Environment and Natural Resources Division § 0.65a Litigation involving Environmental Protection Agency. With respect to any matter assigned to the Environment and Natural Resources Division in... Environment and Natural Resources Division, and such members of his staff as he may specifically designate in...

The International Design Study for the Neutrino Factory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Long, K.

2008-02-21

The International Design Study for a future Neutrino Factory and super-beam facility (the ISS) established the physics case for a high-precision programme of long-baseline neutrino-oscillation measurements. The ISS also identified baseline specifications for the Neutrino Factory accelerator complex and the neutrino detector systems. This paper summarises the objectives of the International Design Study for the Neutrino Factory (the IDS-NF). The IDS-NF will build on the work of the ISS to deliver a Reference Design Report for the Neutrino Factory by 2012/13 and an Interim Design Report by 2010/11.

42 CFR 418.307 - Periodic interim payments.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (CONTINUED) MEDICARE PROGRAM HOSPICE CARE Payment for Hospice Care § 418.307 Periodic interim payments... payments. The biweekly interim payment amount is based on the total estimated Medicare payments for the...

Digital approach to planning computer-guided surgery and immediate provisionalization in a partially edentulous patient.

PubMed

Arunyanak, Sirikarn P; Harris, Bryan T; Grant, Gerald T; Morton, Dean; Lin, Wei-Shao

2016-07-01

This report describes a digital approach for computer-guided surgery and immediate provisionalization in a partially edentulous patient. With diagnostic data obtained from cone-beam computed tomography and intraoral digital diagnostic scans, a digital pathway of virtual diagnostic waxing, a virtual prosthetically driven surgical plan, a computer-aided design and computer-aided manufacturing (CAD/CAM) surgical template, and implant-supported screw-retained interim restorations were realized with various open-architecture CAD/CAM systems. The optional CAD/CAM diagnostic casts with planned implant placement were also additively manufactured to facilitate preoperative inspection of the surgical template and customization of the CAD/CAM-fabricated interim restorations. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

Effects of Solar Array Shadowing on the Power Capability of the Interim Control Module

NASA Technical Reports Server (NTRS)

Fincannon, James; Hojnicki, Jeffrey S.; Garner, James Christopher

1999-01-01

The Interim Control Module (ICM) is being built by the US Naval Research Laboratory (NRL) for NASA as a propulsion module for the International Space Station (ISS). Originally developed as a spinning spacecraft used to move payloads to their final orbit, for ISS, the ICM will be in a fixed orientation and location for long periods resulting in substantial solar panel shadowing. This paper describes the methods used to determine the incident energy incident energy on the ICM solar panels and the power capability of the electric power system (EPS). Applying this methodology has resulted in analyses and assessments used to identify ICM early design changes/options, placement and orientations that enable successful operation of the EPS under a wide variety of anticipated conditions.

Evaluation of Hose in Hose Transfer Line Service Life for Hanfords Interim Stabilization Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

TORRES, T.D.

RPP-6153, Engineering Task Plan for Hose-in-Hose Transfer System for the Interim Stabilization Program (Torres, 2000a), defines the programmatic goals, functional requirements, and technical criteria for the development and subsequent installation of waste transfer line equipment to support Hanford's Interim Stabilization Program. RPP-6028, Specification for Hose in Hose Transfer Lines for Hanford's Interim Stabilization Program (Torres, 2000b), has been issued to define the specific requirements for the design, manufacture, and verification of transfer line assemblies for specific waste transfer applications associated with Interim Stabilization. Included in RPP-6028 are tables defining the chemical constituents of concern to which transfer lines will bemore » exposed. Current Interim Stabilization Program planning forecasts that the at-grade transfer lines will be required to convey pumpable waste for as much as three years after commissioning, RPP-6028 Section 3.2.7. Performance Incentive Number ORP-05 requires that all the Single Shell Tanks be Interim Stabilized by September 30, 2003. The Tri-Party Agreement (TPA) milestone M-41-00, enforced by a federal consent decree, requires all the Single Shell Tanks to be Interim stabilized by September 30, 2004. By meeting the Performance Incentive the TPA milestone is met. Prudent engineering dictates that the equipment used to transfer waste have a life in excess of the forecasted operational time period, with some margin to allow for future adjustments to the planned schedule. This document evaluates the effective service life of the Hose-in-Hose Transfer Lines, based on information submitted by the manufacturer, published literature and calculations. The effective service life of transfer line assemblies is a function of several factors. Foremost among these are the hose material's resistance to the harmful effects of process fluid characteristics, ambient environmental conditions, exposure to ionizing radiation and the manufacturer's stated shelf life. In order to determine the transfer line service life this evaluation examines the certification of shelf life, the certification of chemical compatibility with waste, catalog information of ambient ratings and published literature on the effects of exposure to ionizing radiation on the mechanical properties of elastomeric materials. During initial hose procurements, the hose-in-hose transfer line vendor River Bend Hose Specialty (RBHS) submitted a letter, dated 6/8/00, which recommended the service and shelf life of the hose to be seven years. In submittals for later hose procurements, RBHS submitted a letter, dated 11/6/00, which recommended the service life of the hose to be three years. This submittal was followed by documentation, on 2/14/01, which submitted new storage requirements and restated the seven year shelf life. RBHS revised their original hose service life estimate to a more conservative three years due to concerns over the effects of chemicals in transferred waste. The above mentioned submittals from RBHS are the primary drivers of the three year service life limit established by this document.« less

Instrumentation and Controls Division progress report for the period July 1, 1986 to June 30, 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klobe, L.E.

1988-12-01

The Instrumentation and Controls (IandC) Division of Oak Ridge National Laboratory (ORNL) performs basic and applied instrumentation and controls research, development and design engineering, specialized instrument design and fabrication, and maintenance services for instruments, electronics, and computers. The IandC Division is one of the largest RandD organizations of its type among government laboratories, and it exists as the result of an organizational strategy to integrate ORNL's instrumentation and controls-related disciplines into one dedicated functional organization to increase the Laboratory's expertise and capabilities in these rapidly expanding, innovative areas of technology. The Division participates in the programs and projects of ORNLmore » by applying its expertise and capabilities in concert with other divisions to perform basic research and mission-oriented technology development. Many of the Division's RandD tasks that are a part of a larger ORNL program are of sufficient scope that the IandC effort constitutes a separate program element with direct funding and management responsibility within the Division. The activities of IandC include performance of an RandD task in IandC facilities, the participation of from one of many IandC engineers and scientists in a multidisciplinary team working in a specific research area or development project, design and fabrication of a special instrument or instrumentation system, or a few hours of maintenance service. In its support and maintenance work, the role of the IandC Division is to provide a level of expertise appropriate to complete a job successfully at minimum overall cost and time schedule---a role which involves IandC in almost all ORNL activities.« less

78 FR 41088 - Solicitation for a Cooperative Agreement-Support Services for Community Services Division Networks

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-09

...--Support Services for Community Services Division Networks AGENCY: National Institute of Corrections, U.S... cooperative agreement will provide support services to NIC Community Services Division sponsored networks. The networks are designed for NIC to assist in meeting the needs of the field of community corrections by...

40 CFR 52.1977 - Content of approved State submitted implementation plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Division 28—Stationary Source Air Pollution Control and Permitting Procedures Excess Emissions and... Requirements (11/4/93) 28-1450Enforcement Action Criteria (9/24/93) Division 200—General Air Pollution... Designations (10/14/99) 204-0090Oxygenated Gasoline Control Areas (3/27/01) Division 206—Air Pollution...

40 CFR 52.1977 - Content of approved State submitted implementation plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Division 28—Stationary Source Air Pollution Control and Permitting Procedures Excess Emissions and... Requirements (11/4/93) 28-1450Enforcement Action Criteria (9/24/93) Division 200—General Air Pollution... Designations (10/14/99) 204-0090Oxygenated Gasoline Control Areas (3/27/01) Division 206—Air Pollution...

40 CFR 52.1977 - Content of approved State submitted implementation plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Division 28—Stationary Source Air Pollution Control and Permitting Procedures Excess Emissions and... Requirements (11/4/93) 28-1450Enforcement Action Criteria (9/24/93) Division 200—General Air Pollution... Designations (10/14/99) 204-0090Oxygenated Gasoline Control Areas (3/27/01) Division 206—Air Pollution...

40 CFR 52.1977 - Content of approved State submitted implementation plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Division 28—Stationary Source Air Pollution Control and Permitting Procedures Excess Emissions and... Requirements (11/4/93) 28-1450Enforcement Action Criteria (9/24/93) Division 200—General Air Pollution... Designations (10/14/99) 204-0090Oxygenated Gasoline Control Areas (3/27/01) Division 206—Air Pollution...

Progress report No. 2, design of new pile area {open_quotes}G,{close_quotes} Project C-300, Atomic Energy Commission Directive HW-104

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lowe, P.E.

1950-01-16

This document is the progress report for the design and development of Pile Area {open_quotes}G{close_quotes}, to cover the period June 1, 1949 to December 31, 1949. This project represents the major effort of the Reactor Division of the Design and Construction Divisions. It is being pursued with the aim of being able to incorporate the major project objectives in a finished pile design if that design is begun about January, 1951.

The implementation of the integrated design process in the hole-plan system

NASA Astrophysics Data System (ADS)

Ruy, Won-Sun; Ko, Dae-Eun; Yang, Young-Soon

2012-12-01

All current shipyards are using the customized CAD/CAM programs in order to improve the design quality and increase the design efficiency. Even though the data structures for ship design and construction are almost completed, the implementation related to the ship design processes are still in progress so that it has been the main causes of the bottleneck and delay during the middle of design process. In this study, we thought that the hole-plan system would be a good example which is remained to be improved. The people of outfitting division who don't have direct authority to edit the structural panels, should request the hull design division to install the holes for the outfitting equipment. For acceptance, they should calculate the hole position, determine the hole type, and find the intersected contour of panel. After consideration of the hull people, the requested holes are manually installed on the hull structure. As the above, many processes are needed such as communication and discussion between the divisions, drawings for hole-plan, and the consideration for the structural or production compatibility. However this iterative process takes a lot of working time and requires mental pressure to the related people and cross-division conflict. This paper will handle the hole-plan system in detail to automate the series of process and minimize the human efforts and time-consumption.

Protocol for determining bull trout presence

USGS Publications Warehouse

Peterson, James; Dunham, Jason B.; Howell, Philip; Thurow, Russell; Bonar, Scott

2002-01-01

The Western Division of the American Fisheries Society was requested to develop protocols for determining presence/absence and potential habitat suitability for bull trout. The general approach adopted is similar to the process for the marbled murrelet, whereby interim guidelines are initially used, and the protocols are subsequently refined as data are collected. Current data were considered inadequate to precisely identify suitable habitat but could be useful in stratifying sampling units for presence/absence surveys. The presence/absence protocol builds on previous approaches (Hillman and Platts 1993; Bonar et al. 1997), except it uses the variation in observed bull trout densities instead of a minimum threshold density and adjusts for measured differences in sampling efficiency due to gear types and habitat characteristics. The protocol consists of: 1. recommended sample sizes with 80% and 95% detection probabilities for juvenile and resident adult bull trout for day and night snorkeling and electrofishing adjusted for varying habitat characteristics for 50m and 100m sampling units, 2. sampling design considerations, including possible habitat characteristics for stratification, 3. habitat variables to be measured in the sampling units, and 3. guidelines for training sampling crews. Criteria for habitat strata consist of coarse, watershed-scale characteristics (e.g., mean annual air temperature) and fine-scale, reach and habitat-specific features (e.g., water temperature, channel width). The protocols will be revised in the future using data from ongoing presence/absence surveys, additional research on sampling efficiencies, and development of models of habitat/species occurrence.

Replacement of a hopeless maxillary central incisor: a technique for the fabrication of an immediate implant-supported interim restoration.

PubMed

Graiff, Lorenzo; Vigolo, Paolo

2012-04-01

Placement of a dental implant and an interim restoration in the esthetic zone immediately following tooth extraction is now a common procedure. However, in such clinical situations, the fabrication of an appropriate interim restoration may be challenging. The aim of this article is to present a technique for modifying the extracted tooth so it can be used as an implant-supported interim restoration.

A novel tri-band T-junction impedance-transforming power divider with independent power division ratios

PubMed Central

Zhuang, Zheng; Wang, Weimin; Liu, Yuanan

2017-01-01

In this paper, a novel L network (LN) is presented, which is composed of a frequency-selected section (FSS) and a middle stub (MS). Based on the proposed LN, a tri-band T-junction power divider (TTPD) with impedance transformation and independent power division ratios is designed. Moreover, the closed-form design theory of the TTPD is derived based on the transmission line theory and circuit theory. Finally, a microstrip prototype of the TTPD is simulated, fabricated, and measured. The design is for three arbitrarily chosen frequencies, 1 GHz, 1.6 GHz, and 2.35 GHz with the independent power division ratios of 0.5, 0.7, and 0.9. The measured results show that the fabricated prototype is consistent with the simulation, which demonstrates the effectiveness of this proposed design. PMID:28586372

37 CFR 202.2 - Copyright notice.

Code of Federal Regulations, 2010 CFR

2010-07-01

... may be on a container which is designed and can be expected to remain with the work; (11) The notice...) General. (1) With respect to a work published before January 1, 1978, copyright was secured, or the right to secure it was lost, except for works seeking ad interim copyright, at the date of publication, i.e...

Science: Grade 7. Interim Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education and Training, Winnipeg.

This guide is one of a set of 10 science guides, each covering a separate grade in Manitoba, together covering kindergarten through grade 9. The guides have been designed to provide a framework for building scientific concepts and developing the learning of process skills. They replace an earlier set of guides dated 1979. Each guide is essentially…

9 CFR 92.4 - Reestablishment of a region's disease-free status.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Reestablishment of a region's disease... Requesting Recognition of Regions Other Than for BSE § 92.4 Reestablishment of a region's disease-free status... disease and then experience an outbreak of that disease. (a) Interim designation. If a region recognized...

Science: Grade 6. Interim Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education and Training, Winnipeg.

This guide is one of a set of 10 science guides, each covering a separate grade in Manitoba, together covering kindergarten through grade 9. The guides have been designed to provide a framework for building scientific concepts and developing the learning of process skills. They replace an earlier set of guides dated 1979. Each guide is essentially…

Working Parents Project (WPP). Final Interim Report.

ERIC Educational Resources Information Center

Mason, Theresa; Espinoza, Renato

Results are reported from a 2-year study designed to explore how the nature of women's jobs, as viewed by women and their husbands, influences the system of nuclear family relationships and affects parents' involvement with their children's schools. The research has evolved into a comparative exploratory study of the responses of 30 families to…

Upward Bound Math-Science: Program Description and Interim Impact Estimates

ERIC Educational Resources Information Center

Olsen, Robert; Seftor, Neil; Silva, Tim; Myers, David; DesRoches, David; Young, Julie

2007-01-01

To help address continuing disparities in academic achievement and under-representation of disadvantaged groups in math and science majors and careers, the U.S. Department of Education (ED) established a math and science initiative in 1990 within Upward Bound, a federal grant program known as Upward Bound Math-Science (UBMS) designed to provide…

45 CFR 86.71 - Interim procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Equipment, 86.41(c) Expenditures, 86.41(c) Facilities, 86.41(c) Travel, 86.41(c) Scholarships, [64, 65]; 86...-time employees, [89] G Grievance Procedure, see “Designation of responsible employee”, 86.8(a) (b) H... Undergraduate Professional Schools, [30]; 86.15(d) Purpose of Regulation, [13]; 86.1 R Real Property, 86.2(g...

ATMS concept of operations and generic system requirements : task B : final interim report for design of support systems for advanced traffic management systems

DOT National Transportation Integrated Search

1993-10-01

This document describes the Concept of Operations and Generic System Requirements for : the next generation of Traffic Management Centers (TMC). Four major steps comprise the : development of this Concept of Operations. The first step was to survey t...

An Investigation of Energy Consumption and Cost in Large Air-Conditioned Buildings. An Interim Report.

ERIC Educational Resources Information Center

Milbank, N. O.

Two similarly large buildings and air conditioning systems are comparatively analyzed as to energy consumption, costs, and inefficiency during certain measured periods of time. Building design and velocity systems are compared to heating, cooling, lighting and distribution capabilities. Energy requirements for pumps, fans and lighting are found to…

Implementation of the Career Education Incentive Act. First Interim Report on the Evaluability Assessment.

ERIC Educational Resources Information Center

Jung, Steven M.; And Others

Survey activities are reported which were designed to provide the foundation for a national evaluation of the effectiveness of programs assisted under the Career Education Incentive Act of 1977 (PL 95-207). The methodology described, called "program evaluability assessment," focuses on detailed analysis of program assumptions in order to…

Integrating Quality Assurance Systems in a Merged Higher Education Institution

ERIC Educational Resources Information Center

Kistan, Chandru

2005-01-01

Purpose: This article seeks to highlight the challenges and issues that face merging higher education institutions and also to outline some of the challenges in integrating the quality assurance systems during the pre-, interim and post-merger phases in a merged university. Design/methodology/approach: Case studies of merged and merging…

Progress Report 2013. Turnaround Arts Initiative

ERIC Educational Resources Information Center

Stoelinga, Sara Ray; Joyce, Katie; Silk, Yael

2013-01-01

This interim progress report provides a look at Turnaround Arts schools in their first year, including: (1) a summary of the evaluation design and research questions; (2) a preliminary description of strategies used to introduce the arts in Turnaround Arts schools; and (3) a summary of school reform indicators and student achievement data at…

Science: Grade 8. Interim Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education and Training, Winnipeg.

This guide is one of a set of 10 science guides, each covering a separate grade in Manitoba, together covering kindergarten through grade 9. The guides have been designed to provide a framework for building scientific concepts and developing the learning of process skills. They replace an earlier set of guides dated 1979. Each guide is essentially…

32 CFR 733.3 - Information and policy on support of dependents.

Code of Federal Regulations, 2012 CFR

2012-07-01

... so would lend excessive credence to administrative tools which have been designed for use only within... armed forces). Interim support for each family member shall be either $200.00 per supported family... of 1/3 gross pay, per month. (4) Both spouses in the armed forces. (i) No children of the marriage...

Science: Grade 2. Interim Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education and Training, Winnipeg.

This guide is one of a set of 10 science guides, each covering a separate grade in Manitoba, together covering kindergarten through grade 9. The guides have been designed to provide a framework for building scientific concepts and developing the learning of process skills. They replace an earlier set of guides dated 1979. Each guide is essentially…

Science: Grade 1. Interim Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education and Training, Winnipeg.

This guide is one of a set of 10 science guides, each covering a separate grade in Manitoba, together covering kindergarten through grade 9. The guides have been designed to provide a framework for building scientific concepts and developing the learning of process skills. They replace an earlier set of guides dated 1979. Each guide is essentially…

Science: Kindergarten. Interim Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education and Training, Winnipeg.

This guide is one of a set of 10 science guides, each covering a separate grade in Manitoba, together covering kindergarten through grade 9. The guides have been designed to provide a framework for building scientific concepts and developing the learning of process skills. They replace an earlier set of guides dated 1979. Each guide is essentially…

An evaluation of the following too closely monitor system on a four-lane undivided highway : interim report.

DOT National Transportation Integrated Search

1976-01-01

The FOLLOWING TOO CLOSELY (FTC) MONITOR system is an experimental device designed to measure vehicle gaps at a point along the highway and to advise the motorist, by means of a flashing message on a sign, that he is following the car in front of him ...

Science 26: Teacher Resource Manual. Integrated Occupational Program. Interim 1991.

ERIC Educational Resources Information Center

Alberta Dept. of Education, Edmonton. Curriculum Branch.

The Integrated Occupation Science 26 Program is an optional program designed to allow students in Alberta, Canada to meet the credit requirements of the Certificate of Achievement and facilitate transfer to the General High School Diploma Program. This Teacher Resource Manual is provided to assist classroom teachers to implement the Science 26…

The IRIS-GUS Shuttle Borne Upper Stage System

NASA Technical Reports Server (NTRS)

Tooley, Craig; Houghton, Martin; Bussolino, Luigi; Connors, Paul; Broudeur, Steve (Technical Monitor)

2002-01-01

This paper describes the Italian Research Interim Stage - Gyroscopic Upper Stage (IRIS-GUS) upper stage system that will be used to launch NASA's Triana Observatory from the Space Shuttle. Triana is a pathfinder earth science mission being executed on rapid schedule and small budget, therefore the mission's upper stage solution had to be a system that could be fielded quickly at relatively low cost and risk. The building of the IRIS-GUS system wa necessary because NASA lost the capability to launch moderately sized upper stage missions fro the Space Shuttle when the PAM-D system was retired. The IRIS-GUS system restores this capability. The resulting system is a hybrid which mates the existing, flight proven IRIS (Italian Research Interim Stage) airborne support equipment to a new upper stage, the Gyroscopic Upper Stage (GUS) built by the GSFC for Triana. Although a new system, the GUS exploits flight proven hardware and design approaches in most subsystems, in some cases implementing proven design approaches with state-of-the-art electronics. This paper describes the IRIS-GUS upper stage system elements, performance capabilities, and payload interfaces.

International validation study for interim PET in ABVD-treated, advanced-stage hodgkin lymphoma: interpretation criteria and concordance rate among reviewers.

PubMed

Biggi, Alberto; Gallamini, Andrea; Chauvie, Stephane; Hutchings, Martin; Kostakoglu, Lale; Gregianin, Michele; Meignan, Michel; Malkowski, Bogdan; Hofman, Michael S; Barrington, Sally F

2013-05-01

At present, there are no standard criteria that have been validated for interim PET reporting in lymphoma. In 2009, an international workshop attended by hematologists and nuclear medicine experts in Deauville, France, proposed to develop simple and reproducible rules for interim PET reporting in lymphoma. Accordingly, an international validation study was undertaken with the primary aim of validating the prognostic role of interim PET using the Deauville 5-point score to evaluate images and with the secondary aim of measuring concordance rates among reviewers using the same 5-point score. This paper focuses on the criteria for interpretation of interim PET and on concordance rates. A cohort of advanced-stage Hodgkin lymphoma patients treated with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) were enrolled retrospectively from centers worldwide. Baseline and interim scans were reviewed by an international panel of 6 nuclear medicine experts using the 5-point score. Complete scan datasets of acceptable diagnostic quality were available for 260 of 440 (59%) enrolled patients. Independent agreement among reviewers was reached on 252 of 260 patients (97%), for whom at least 4 reviewers agreed the findings were negative (score of 1-3) or positive (score of 4-5). After discussion, consensus was reached in all cases. There were 45 of 260 patients (17%) with positive interim PET findings and 215 of 260 patients (83%) with negative interim PET findings. Thirty-three interim PET-positive scans were true-positive, and 12 were false-positive. Two hundred three interim PET-negative scans were true-negative, and 12 were false-negative. Sensitivity, specificity, and accuracy were 0.73, 0.94, and 0.91, respectively. Negative predictive value and positive predictive value were 0.94 and 0.73, respectively. The 3-y failure-free survival was 83%, 28%, and 95% for the entire population and for interim PET-positive and -negative patients, respectively (P < 0.0001). The agreement between pairs of reviewers was good or very good, ranging from 0.69 to 0.84 as measured with the Cohen kappa. Overall agreement was good at 0.76 as measured with the Krippendorf α. The 5-point score proposed at Deauville for reviewing interim PET scans in advanced Hodgkin lymphoma is accurate and reproducible enough to be accepted as a standard reporting criterion in clinical practice and for clinical trials.

Publishing interim results of randomised clinical trials in peer-reviewed journals.

PubMed

Counsell, Nicholas; Biri, Despina; Fraczek, Joanna; Hackshaw, Allan

2017-02-01

Interim analyses of randomised controlled trials are sometimes published before the final results are available. In several cases, the treatment effects were noticeably different after patient recruitment and follow-up completed. We therefore conducted a literature review of peer-reviewed journals to compare the reported treatment effects between interim and final publications and to examine the magnitude of the difference. We performed an electronic search of MEDLINE from 1990 to 2014 (keywords: 'clinical trial' OR 'clinical study' AND 'random*' AND 'interim' OR 'preliminary'), and we manually identified the corresponding final publication. Where the electronic search produced a final report in which the abstract cited interim results, we found the interim publication. We also manually searched every randomised controlled trial in eight journals, covering a range of impact factors and general medical and specialist publications (1996-2014). All paired articles were checked to ensure that the same comparison between interventions was available in both. In all, 63 studies are included in our review, and the same quantitative comparison was available in 58 of these. The final treatment effects were smaller than the interim ones in 39 (67%) trials and the same size or larger in 19 (33%). There was a marked reduction, defined as a ≥20% decrease in the size of the treatment effect from interim to final analysis, in 11 (19%) trials compared to a marked increase in 3 (5%), p = 0.057. The magnitude of percentage change was larger in trials where commercial support was reported, and increased as the proportion of final events at the interim report decreased in trials where commercial support was reported (interaction p = 0.023). There was no evidence of a difference between trials that stopped recruitment at the interim analysis where this was reported as being pre-specified versus those that were not pre-specified (interaction p = 0.87). Published interim trial results were more likely to be associated with larger treatment effects than those based on the final report. Publishing interim results should be discouraged, in order to have reliable estimates of treatment effects for clinical decision-making, regulatory authority reviews and health economic analyses. Our work should be expanded to include conference publications and manual searches of additional journal publications.

WFIRST Project Science Activities

NASA Technical Reports Server (NTRS)

Gehrels, Neil

2012-01-01

The WFIRST Project is a joint effort between GSFC and JPL. The project scientists and engineers are working with the community Science Definition Team to define the requirements and initial design of the mission. The objective is to design an observatory that meets the WFIRST science goals of the Astr02010 Decadal Survey for minimum cost. This talk will be a report of recent project activities including requirements flowdown, detector array development, science simulations, mission costing and science outreach. Details of the interim mission design relevant to scientific capabilities will be presented.

Preliminary design package for residential heating/cooling system: Rankine air conditioner redesign

NASA Technical Reports Server (NTRS)

1978-01-01

A summary of the preliminary redesign and development of a marketable single family heating and cooling system is presented. The interim design and schedule status of the residential (3-ton) redesign, problem areas and solutions, and the definition of plans for future design and development activities were discussed. The proposed system for a single-family residential heating and cooling system is a single-loop, solar-assisted, hydronic-to-warm-air heating subsystem with solar-assisted domestic water heating and a Rankine-driven expansion air-conditioning subsystem.

Different predictive values of interim 18F-FDG PET/CT in germinal center like and non-germinal center like diffuse large B-cell lymphoma.

PubMed

Kim, Jihyun; Lee, Jeong-Ok; Paik, Jin Ho; Lee, Won Woo; Kim, Sang Eun; Song, Yoo Sung

2017-01-01

Diffuse large B-cell lymphoma (DLBCL) is a pathologically heterogeneous disease with different prognoses according to its molecular profiles. Despite the broad usage of 18 F-fluoro-2-dexoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT), previous studies that have investigated the value of interim 18 F-FDG PET/CT in DLBCL have given the controversial results. The purpose of this study was to evaluate the prognostic value of interim 18 F-FDG PET/CT in DLBCL according to germinal center B cell-like (GCB) and non-GCB molecular profiling. We enrolled 118 newly diagnosed DLBCL patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). Interim 18 F-FDG PET/CT scans performed after 2 or 3 cycles of R-CHOP treatment were evaluated based on the Lugano response criteria. Patients were grouped as GCB or non-GCB molecular subtypes according to immunohistochemistry results of CD10, BCL6, and MUM1, based on Hans' algorithm. In total 118 DLBCL patients, 35 % were classified as GCB, and 65 % were classified as non-GCB. Interim PET/CT was negative in 70 %, and positive in 30 %. During the median follow-up period of 23 months, the positive interim 18 F-FDG PET/CT group showed significantly inferior progression free survival (PFS) compared to the negative interim 18 F-FDG PET/CT group (P = 0.0004) in entire patients. A subgroup analysis according to molecular profiling demonstrated significant difference of PFS between the positive and negative interim 18 F-FDG PET groups in GCB subtype of DLBCL (P = 0.0001), but there was no significant difference of PFS between the positive and negative interim 18 F-FDG PET groups in non-GCB subtype of DLBCL. Interim 18 F-FDG PET/CT scanning had a significant predictive value for disease progression in patients with the GCB subtype of DLBCL treated with R-CHOP, but not in those with the non-GCB subtype. Therefore, molecular profiles of DLBCL should be considered for interim 18 F-FDG PET/CT practice.

MANTECH project book

NASA Astrophysics Data System (ADS)

The effective integration of processes, systems, and procedures used in the production of aerospace systems using computer technology is managed by the Integration Technology Division (MTI). Under its auspices are the Information Management Branch, which is actively involved with information management, information sciences and integration, and the Implementation Branch, whose technology areas include computer integrated manufacturing, engineering design, operations research, and material handling and assembly. The Integration Technology Division combines design, manufacturing, and supportability functions within the same organization. The Processing and Fabrication Division manages programs to improve structural and nonstructural materials processing and fabrication. Within this division, the Metals Branch directs the manufacturing methods program for metals and metal matrix composites processing and fabrication. The Nonmetals Branch directs the manufacturing methods programs, which include all manufacturing processes for producing and utilizing propellants, plastics, resins, fibers, composites, fluid elastomers, ceramics, glasses, and coatings. The objective of the Industrial Base Analysis Division is to act as focal point for the USAF industrial base program for productivity, responsiveness, and preparedness planning.

Guidance: Interim Municipal Settlement Policy

EPA Pesticide Factsheets

Interim guidance and fact sheets regarding settlements involving municipalities or municipal waste under Section 122 CERCLA as amended by SARA. Interim policy sets forth the criteria by which EPA generally determines whether to exercise enforcement discretion to pursue MSW generators and transporters as PRPs.

JT9D ceramic outer air seal system refinement program

NASA Technical Reports Server (NTRS)

Gaffin, W. O.

1982-01-01

The abradability and durability characteristics of the plasma sprayed system were improved by refinement and optimization of the plasma spray process and the metal substrate design. The acceptability of the final seal system for engine testing was demonstrated by an extensive rig test program which included thermal shock tolerance, thermal gradient, thermal cycle, erosion, and abradability tests. An interim seal system design was also subjected to 2500 endurance test cycles in a JT9D-7 engine.

Global Spent Fuel Logistics Systems Study (GSFLS). Volume 3A. GSFLS technical analysis (appendix). Interim report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kriger, A.

1978-01-31

This report is a part of the interim report documentation for the Global Spent Fuel Logistics System (GSFLS) study. The technical and financial considerations underlying a global spent fuel logistics systems have been studied and are reported. The Pacific Basin is used as a model throughout this report; however the stated methodology and, in many cases, considerations and conclusions are applicable to other global regions. Spent fuel discharge profiles for Pacific Basin Countries were used to determine the technical systems requirements for alternative concepts. Functional analyses and flows were generated to define both system design requirements and logistics parameters. Amore » technology review was made to ascertain the state-of-the-art of relevant GSFLS technical systems. Modular GSFLS facility designs were developed using the information generated from the functional analysis and technology review. The modular facility designs were used as a basis for siting and cost estimates for various GSFLS alternatives. Various GSFLS concepts were analyzed from a financial and economic perspective in order to provide total concepts costs and ascertain financial and economic sensitivities to key GSFLS variations. Results of the study include quantification of GSFLS facility and hardware requirements; drawings of relevant GSFLS facility designs; system cost estimates; financial reports - including user service charges; and comparative analyses of various GSFLS alternatives.« less

28 CFR 94.41 - Interim emergency payment.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Interim emergency payment. 94.41 Section 94.41 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIME VICTIM SERVICES International Terrorism Victim Expense Reimbursement Program Payment of Claims § 94.41 Interim emergency payment...

28 CFR 94.41 - Interim emergency payment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Interim emergency payment. 94.41 Section 94.41 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIME VICTIM SERVICES International Terrorism Victim Expense Reimbursement Program Payment of Claims § 94.41 Interim emergency payment...

28 CFR 94.41 - Interim emergency payment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Interim emergency payment. 94.41 Section 94.41 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIME VICTIM SERVICES International Terrorism Victim Expense Reimbursement Program Payment of Claims § 94.41 Interim emergency payment...

28 CFR 94.41 - Interim emergency payment.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Interim emergency payment. 94.41 Section 94.41 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIME VICTIM SERVICES International Terrorism Victim Expense Reimbursement Program Payment of Claims § 94.41 Interim emergency payment...

28 CFR 94.41 - Interim emergency payment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Interim emergency payment. 94.41 Section 94.41 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIME VICTIM SERVICES International Terrorism Victim Expense Reimbursement Program Payment of Claims § 94.41 Interim emergency payment...

76 FR 4369 - Special Law Enforcement Commissions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Special Law Enforcement Commissions AGENCY... of the Interim Special Law Enforcement Commission Policy, Rules and Procedures, the Interim Special Law Enforcement Commission Protocols and the Interim Domestic Violence Waiver that will be used by the...

47 CFR 51.715 - Interim transport and termination pricing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Interim transport and termination pricing. 51... SERVICES (CONTINUED) INTERCONNECTION Reciprocal Compensation for Transport and Termination of Telecommunications Traffic § 51.715 Interim transport and termination pricing. (a) Upon request from a...

47 CFR 51.715 - Interim transport and termination pricing.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 3 2011-10-01 2011-10-01 false Interim transport and termination pricing. 51... SERVICES (CONTINUED) INTERCONNECTION Reciprocal Compensation for Transport and Termination of Telecommunications Traffic § 51.715 Interim transport and termination pricing. (a) Upon request from a...

33 CFR 385.9 - Implementation principles.

Code of Federal Regulations, 2013 CFR

2013-07-01

... of the Plan at specific time intervals during implementation. Interim targets to evaluate progress on... accordance with § 385.39. Interim goals and interim targets shall be consistent with each other. (c... ensure that new information resulting from changed or unforeseen circumstances, new scientific and...

33 CFR 385.9 - Implementation principles.

Code of Federal Regulations, 2014 CFR

2014-07-01

... of the Plan at specific time intervals during implementation. Interim targets to evaluate progress on... accordance with § 385.39. Interim goals and interim targets shall be consistent with each other. (c... ensure that new information resulting from changed or unforeseen circumstances, new scientific and...

33 CFR 385.9 - Implementation principles.

Code of Federal Regulations, 2011 CFR

2011-07-01

... of the Plan at specific time intervals during implementation. Interim targets to evaluate progress on... accordance with § 385.39. Interim goals and interim targets shall be consistent with each other. (c... ensure that new information resulting from changed or unforeseen circumstances, new scientific and...

33 CFR 385.9 - Implementation principles.

Code of Federal Regulations, 2012 CFR

2012-07-01

... of the Plan at specific time intervals during implementation. Interim targets to evaluate progress on... accordance with § 385.39. Interim goals and interim targets shall be consistent with each other. (c... ensure that new information resulting from changed or unforeseen circumstances, new scientific and...

HEP Division Argonne National Laboratory

Science.gov Websites

Design Neutrino Physics Theoretical Physics Seminars HEP Division Seminar HEP Lunch Seminar HEP Theory administrators theory users trice users HEP webmaster U.S. Department of Energy Office of Science | UChicago

Coordinated Research in Robotics and Integrated Manufacturing.

DTIC Science & Technology

1983-07-31

of three research divisions: Robot Systems, Management Systems, and Integrated Design and Manufacturing, and involves about 40 faculty spanning the...keystone of their program. A relatively smaller level of effort is being supported within the Management Systems Division. This is the first annual...SYSTEMS MANAGEMENT 0 DESIGN DATABASES " ROBOT-BASED 0 HUMAN FACTORSMANUFACTURING • CAD CELL* PRODUCTIONMUCR LANNING * INTEGRATION LANGUAGE AND VIA LOCAL

Data-Division-Specific Robustness and Power of Randomization Tests for ABAB Designs

ERIC Educational Resources Information Center

Manolov, Rumen; Solanas, Antonio; Bulte, Isis; Onghena, Patrick

2010-01-01

This study deals with the statistical properties of a randomization test applied to an ABAB design in cases where the desirable random assignment of the points of change in phase is not possible. To obtain information about each possible data division, the authors carried out a conditional Monte Carlo simulation with 100,000 samples for each…

Mountain-Plains Handbook: The Design and Operation of a Residential Family Based Education Program. Appendix. Supplement II to Volume 5. Operational Support: Administrative Services Division.

ERIC Educational Resources Information Center

Anderson, Newell B.; And Others

One of two supplements which accompany chapter 5 of "Mountain-Plains Handbook: The Design and Operation of a Residential, Family Oriented Career Education Model" (CE 014 630), this document contains specific information concerning the following components of the administrative services division: purchasing, property control, and…

Composite Ceramic Superconducting Wires for Electric Motor Applications

DTIC Science & Technology

1988-12-30

current a-yi t6-ransition. - Emerson Motor Division has begun work on DC heteropolar and homopolar motor designs. The mechanical stresses on conventional...Emerson Motor Division has begun work on DC heteropolar motor designs and, through Professor Novotny at U. Wisconsin, DC homopolar machines. The...123 3.2 Literature Research .............................. .. 124 3 3.3 Application Study .............................. .. 124 3.3.1 Homopolar Motor

Mountain-Plains Handbook: The Design and Operation of a Residential Family Based Education Program. Appendix. Supplement I to Volume 5. Operational Support: Administrative Services Division.

ERIC Educational Resources Information Center

Anderson, Newell B.; And Others

One of two supplements which accompany chapter 5 of "Mountain-Plains Handbook: The Design and Operation of a Residential, Family Oriented Career Education Model" (CE 014 630), this document contains specific information concerning the reprographic and personnel components of the administrative services division. Several job descriptions…

An Evaluation of the Model School Division (MSD) Preschool Program for the School Year 1973-74.

ERIC Educational Resources Information Center

District of Columbia Public Schools, Washington, DC. Dept. of Research and Evaluation.

This study was designed to assess the extent to which children served by the Model Schools Division Preschool Program developed socially, intellectually, physically and emotionally during the 1973-74 school year. This evaluation was also designed to measure the appropriateness of the learning environment and the amount of services provided by the…

Diffractive optics for combined spatial- and mode- division demultiplexing of optical vortices: design, fabrication and optical characterization.

PubMed

Ruffato, Gianluca; Massari, Michele; Romanato, Filippo

2016-04-20

During the last decade, the orbital angular momentum (OAM) of light has attracted growing interest as a new degree of freedom for signal channel multiplexing in order to increase the information transmission capacity in today's optical networks. Here we present the design, fabrication and characterization of phase-only diffractive optical elements (DOE) performing mode-division (de)multiplexing (MDM) and spatial-division (de)multiplexing (SDM) at the same time. Samples have been fabricated with high-resolution electron-beam lithography patterning a polymethylmethacrylate (PMMA) resist layer spun over a glass substrate. Different DOE designs are presented for the sorting of optical vortices differing in either OAM content or beam size in the optical regime, with different steering geometries in far-field. These novel DOE designs appear promising for telecom applications both in free-space and in multi-core fibers propagation.

A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials

PubMed Central

2009-01-01

Background Decisions about interim analysis and early stopping of clinical trials, as based on recommendations of Data Monitoring Committees (DMCs), have far reaching consequences for the scientific validity and clinical impact of a trial. Our aim was to evaluate the frequency and quality of the reporting on DMC composition and roles, interim analysis and early termination in pediatric trials. Methods We conducted a systematic review of randomized controlled clinical trials published from 2005 to 2007 in a sample of four general and four pediatric journals. We used full-text databases to identify trials which reported on DMCs, interim analysis or early termination, and included children or adolescents. Information was extracted on general trial characteristics, risk of bias, and a set of parameters regarding DMC composition and roles, interim analysis and early termination. Results 110 of the 648 pediatric trials in this sample (17%) reported on DMC or interim analysis or early stopping, and were included; 68 from general and 42 from pediatric journals. The presence of DMCs was reported in 89 of the 110 included trials (81%); 62 papers, including 46 of the 89 that reported on DMCs (52%), also presented information about interim analysis. No paper adequately reported all DMC parameters, and nine (15%) reported all interim analysis details. Of 32 trials which terminated early, 22 (69%) did not report predefined stopping guidelines and 15 (47%) did not provide information on statistical monitoring methods. Conclusions Reporting on DMC composition and roles, on interim analysis results and on early termination of pediatric trials is incomplete and heterogeneous. We propose a minimal set of reporting parameters that will allow the reader to assess the validity of trial results. PMID:20003383

78 FR 55339 - Regulatory Capital Rules: Regulatory Capital, Implementation of Basel III, Capital Adequacy...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-10

...The Federal Deposit Insurance Corporation (FDIC) is adopting an interim final rule that revises its risk-based and leverage capital requirements for FDIC-supervised institutions. This interim final rule is substantially identical to a joint final rule issued by the Office of the Comptroller of the Currency (OCC) and the Board of Governors of the Federal Reserve System (Federal Reserve) (together, with the FDIC, the agencies). The interim final rule consolidates three separate notices of proposed rulemaking that the agencies jointly published in the Federal Register on August 30, 2012, with selected changes. The interim final rule implements a revised definition of regulatory capital, a new common equity tier 1 minimum capital requirement, a higher minimum tier 1 capital requirement, and, for FDIC-supervised institutions subject to the advanced approaches risk-based capital rules, a supplementary leverage ratio that incorporates a broader set of exposures in the denominator. The interim final rule incorporates these new requirements into the FDIC's prompt corrective action (PCA) framework. In addition, the interim final rule establishes limits on FDIC-supervised institutions' capital distributions and certain discretionary bonus payments if the FDIC-supervised institution does not hold a specified amount of common equity tier 1 capital in addition to the amount necessary to meet its minimum risk-based capital requirements. The interim final rule amends the methodologies for determining risk-weighted assets for all FDIC-supervised institutions. The interim final rule also adopts changes to the FDIC's regulatory capital requirements that meet the requirements of section 171 and section 939A of the Dodd-Frank Wall Street Reform and Consumer Protection Act. The interim final rule also codifies the FDIC's regulatory capital rules, which have previously resided in various appendices to their respective regulations, into a harmonized integrated regulatory framework. In addition, the FDIC is amending the market risk capital rule (market risk rule) to apply to state savings associations. The FDIC is issuing these revisions to its capital regulations as an interim final rule. The FDIC invites comments on the interaction of this rule with other proposed leverage ratio requirements applicable to large, systemically important banking organizations. This interim final rule otherwise contains regulatory text that is identical to the common rule text adopted as a final rule by the Federal Reserve and the OCC. This interim final rule enables the FDIC to proceed on a unified, expedited basis with the other federal banking agencies pending consideration of other issues. Specifically, the FDIC intends to evaluate this interim final rule in the context of the proposed well- capitalized and buffer levels of the supplementary leverage ratio applicable to large, systemically important banking organizations, as described in a separate Notice of Proposed Rulemaking (NPR) published in the Federal Register August 20, 2013. The FDIC is seeking commenters' views on the interaction of this interim final rule with the proposed rule regarding the supplementary leverage ratio for large, systemically important banking organizations.

Analysis of phase II methodologies for single-arm clinical trials with multiple endpoints in rare cancers: An example in Ewing's sarcoma.

PubMed

Dutton, P; Love, S B; Billingham, L; Hassan, A B

2018-05-01

Trials run in either rare diseases, such as rare cancers, or rare sub-populations of common diseases are challenging in terms of identifying, recruiting and treating sufficient patients in a sensible period. Treatments for rare diseases are often designed for other disease areas and then later proposed as possible treatments for the rare disease after initial phase I testing is complete. To ensure the trial is in the best interests of the patient participants, frequent interim analyses are needed to force the trial to stop promptly if the treatment is futile or toxic. These non-definitive phase II trials should also be stopped for efficacy to accelerate research progress if the treatment proves to be particularly promising. In this paper, we review frequentist and Bayesian methods that have been adapted to incorporate two binary endpoints and frequent interim analyses. The Eurosarc Trial of Linsitinib in advanced Ewing Sarcoma (LINES) is used as a motivating example and provides a suitable platform to compare these approaches. The Bayesian approach provides greater design flexibility, but does not provide additional value over the frequentist approaches in a single trial setting when the prior is non-informative. However, Bayesian designs are able to borrow from any previous experience, using prior information to improve efficiency.

Final Report: Characterization of Canister Mockup Weld Residual Stresses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Enos, David; Bryan, Charles R.

2016-12-01

Stress corrosion cracking (SCC) of interim storage containers has been indicated as a high priority data gap by the Department of Energy (DOE) (Hanson et al., 2012), the Electric Power Research Institute (EPRI, 2011), the Nuclear Waste Technical Review Board (NWTRB, 2010a), and the Nuclear Regulatory Commission (NRC, 2012a, 2012b). Uncertainties exist in terms of the environmental conditions that prevail on the surface of the storage containers, the stress state within the container walls associated both with weldments as well as within the base metal itself, and the electrochemical properties of the storage containers themselves. The goal of the workmore » described in this document is to determine the stress states that exists at various locations within a typical storage canister by evaluating the properties of a full-diameter cylindrical mockup of an interim storage canister. This mockup has been produced using the same manufacturing procedures as the majority of the fielded spent nuclear fuel interim storage canisters. This document describes the design and procurement of the mockup and the characterization of the stress state associated with various portions of the container. It also describes the cutting of the mockup into sections for further analyses, and a discussion of the potential impact of the results from the stress characterization effort.« less

Color stability and marginal integrity of interim crowns: An in vitro study

PubMed Central

Elagra, Marwa I.; Rayyan, Mohammad R.; Alhomaidhi, Maisam M.; Alanaziy, Areej A.; Alnefaie, Mona O.

2017-01-01

Objective: Many commercial dental materials are used to fabricate interim restorations. This study aimed to compare the color stability and the marginal integrity of four different interim crown materials. Materials and Methods: An ivorine right maxillary central incisor was prepared for a full coverage all-ceramic restoration. A total of 36 specimens in the form of crowns were fabricated on the master die using four different materials (n = 9); Polymethyl methacrylate (PMMA) resin (TrimPLUS), PMMA computer-aided design, and computer-aided manufacturing (CAD-CAM) blocks (Ceramill TEMP), cold cure bis-acryl resin (Success CD), and bis-acryl resin dual-cure composite (TempSpan). Color change ΔE for each sample was calculated by measuring its color as Commission Internationale de l’Eclairage L* a* b* with a spectrophotometer before and after immersing in a concentrated tea solution for 7 days. Marginal gap was measured at four reference points using stereomicroscope at ×40. One-way ANOVA and the Tukey multiple comparisons test were used to determine any statistically significant difference between the four groups, (α = 0.05). Results: Success CD showed significantly the greatest color change (7.7) among all the tested materials, while no significant difference was found between the other three materials. TempSpan showed significantly the highest marginal gap formation (430.15 μm), while no significant difference was found between the three other materials. Conclusions: Bis-acryl resin composite materials demonstrated clinically noticeable change in color while PMMA materials demonstrated superior color stability. Dual cure interim materials exhibited significantly higher marginal discrepancy in comparison to PMMA and cold cure bis-acrylic resin materials. CAD-CAM PMMA material exhibited the best color stability and marginal integrity. PMID:28932142

Chronic toxicity studies on 1,3,5-trinitrobenzene in Fischer 344 rats. Final report, 1 May 1993-30 April 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reddy, T.V.; Daniel, F.B.; Olson, G.R.

1996-02-01

Chronic toxic effects of I ,3,5-tnnitriotrobenzene (TNB) in male and female Fischer rats were evaluated by feeding certified powdered laboratory chow diet supplemented with varied concentrations of TNB (0, 5, 60 and 300 mg/kg diet). The study was designed to accommodate three interim sacrifices (10 rats/group/sex) at 90, 180 and 365 days. The final sacrifice was performed after two years. All data related to these interim sacrifices are presented independently in appendices J to L. The calculated average TNB consumption for females was 0.23, 2.68 and 13.31 mg/kg/day and was 0.22, 2.64 and 13.44 mg/kg/day for males. Terminal body weightsmore » were significantly decreased in both sexes in the 300 mg/kg group. Relative spleen weights were decreased in both sexes in the 300 mg/kg group while brain weights were increased in females in this same group. Methemoglobin was increased in both sexes in the 300 mg/kg group while other hematological effects noted at the interim sacrifice times were not evident at two years. Histopathological examinations suggested treatment related changes in both sexes involving the kidneys (cytoplasmic/hyaline droplets) in the 60 and 300 mg/kg groups and the spleen (erythroid cell hyperplasia and pigment deposition) in the 300 mg/kg group. The cytoplasmic/hyaline droplets were characterized by immunohistochemistry as alpha-2u-globulin. These renal droplets were also noted at the interim sacrifice times. A no observed adverse effect level (NOAEL) was established in this study at 2.68 mg/kg b.w./day for F-344 rats administered TNB for two years.« less

Las Matematicas: Lenguaje Universal. Nivel 2b: Multiplicacion y Division de Numeros Enteros (Mathematics: A Universal Language. Level 2b: Multiplication and Division of Whole Numbers).

ERIC Educational Resources Information Center

Dissemination and Assessment Center for Bilingual Education, Austin, TX.

This is one of a series of student booklets designed for use in a bilingual mathematics program in grades 6-8. The general format is to present each page in both Spanish and English. The mathematical topics in this booklet include multiplication and division. (MK)

42 CFR 417.574 - Interim settlement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Interim settlement. 417.574 Section 417.574 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... PLANS Medicare Payment: Cost Basis § 417.574 Interim settlement. (a) Determination. Within 30 days...

14 CFR 136.41 - Interim operating authority.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Interim operating authority. 136.41 Section 136.41 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... technology, as appropriate, and (9) Shall allow for modifications of the interim operating authority based on...

14 CFR 136.41 - Interim operating authority.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Interim operating authority. 136.41 Section 136.41 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... technology, as appropriate, and (9) Shall allow for modifications of the interim operating authority based on...

47 CFR 73.404 - Interim hybrid IBOC DAB operation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 4 2012-10-01 2012-10-01 false Interim hybrid IBOC DAB operation. 73.404 Section 73.404 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Digital Audio Broadcasting § 73.404 Interim hybrid IBOC DAB operation. (a) The...

47 CFR 73.404 - Interim hybrid IBOC DAB operation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 4 2011-10-01 2011-10-01 false Interim hybrid IBOC DAB operation. 73.404 Section 73.404 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Digital Audio Broadcasting § 73.404 Interim hybrid IBOC DAB operation. (a) The...

47 CFR 73.404 - Interim hybrid IBOC DAB operation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 4 2013-10-01 2013-10-01 false Interim hybrid IBOC DAB operation. 73.404 Section 73.404 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Digital Audio Broadcasting § 73.404 Interim hybrid IBOC DAB operation. (a) The...

47 CFR 73.404 - Interim hybrid IBOC DAB operation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 4 2014-10-01 2014-10-01 false Interim hybrid IBOC DAB operation. 73.404 Section 73.404 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Digital Audio Broadcasting § 73.404 Interim hybrid IBOC DAB operation. (a) The...

10 CFR 590.403 - Emergency interim orders.

Code of Federal Regulations, 2010 CFR

2010-01-01

... DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS Opinions and Orders § 590.403 Emergency interim... and issue an emergency interim order authorizing the import or export of natural gas. After issuance...

EPA Interim Evaluation of 2016-2017 Milestone Progress in the Chesapeake Bay Watershed

EPA Pesticide Factsheets

This page provides the EPA interim evaluations of the 2016-2017 milestones for the Chesapeake Bay TMDL. These interim assessments provide a mid-point check on the progress made on the 2016-2017 milestones, recognizing the achievements made in 2016.

EPA Interim Evaluation of 2012-2013 Milestone Progress in the Chesapeake Bay Watershed

EPA Pesticide Factsheets

This page provides the EPA interim evaluations of the 2012-2013 milestones for the Chesapeake Bay TMDL. These interim assessments provide a mid-point check on the progress made on the 2012-2013 milestones, recognizing the achievements made in 2012.

49 CFR 37.193 - Interim service requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Interim service requirements. 37.193 Section 37.193 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.193 Interim service requirements. (a) Until...

76 FR 57657 - Tetrachlorvinphos; Extension of Time-Limited Interim Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-16

...] Tetrachlorvinphos; Extension of Time-Limited Interim Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This regulation establishes an extension of time-limited interim..., and Cosmetic Act (FFDCA). The time-limited tolerances expire on March 18, 2013. DATES: This regulation...

EPA Interim Evaluation of 2014-2015 Milestone Progress in the Chesapeake Bay Watershed

EPA Pesticide Factsheets

This page provides the EPA interim evaluations of the 2014-2015 milestones for the Chesapeake Bay TMDL. These interim assessments provide a mid-point check on the progress made on the 2014-2015 milestones, recognizing the achievements made in 2014.

45 CFR 1623.6 - Interim funding.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Interim funding. 1623.6 Section 1623.6 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION SUSPENSION PROCEDURES § 1623.6 Interim funding. (a) Pending the completion of suspension proceedings under this part...

45 CFR 1623.6 - Interim funding.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Interim funding. 1623.6 Section 1623.6 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION SUSPENSION PROCEDURES § 1623.6 Interim funding. (a) Pending the completion of suspension proceedings under this part...

45 CFR 1623.6 - Interim funding.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Interim funding. 1623.6 Section 1623.6 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION SUSPENSION PROCEDURES § 1623.6 Interim funding. (a) Pending the completion of suspension proceedings under this part...

45 CFR 1623.6 - Interim funding.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Interim funding. 1623.6 Section 1623.6 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION SUSPENSION PROCEDURES § 1623.6 Interim funding. (a) Pending the completion of suspension proceedings under this part...

45 CFR 1623.6 - Interim funding.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Interim funding. 1623.6 Section 1623.6 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION SUSPENSION PROCEDURES § 1623.6 Interim funding. (a) Pending the completion of suspension proceedings under this part...

An interim prosthesis program for lower limb amputees: comparison of public and private models of service.

PubMed

Gordon, Robert; Magee, Christopher; Frazer, Anna; Evans, Craig; McCosker, Kathryn

2010-06-01

This study compared the outcomes of an interim mechanical prosthesis program for lower limb amputees operated under a public and private model of service. Over a two-year period, 60 transtibial amputees were fitted with an interim prosthesis as part of their early amputee care. Thirty-four patients received early amputee care under a public model of service, whereby a prosthetist was employed to provide the interim mechanical prosthesis service. The remaining 26 patients received early amputee care under a private model of service, where an external company was contracted to provide the interim mechanical prosthesis service. The results suggested comparable clinical outcomes between the two patient groups. However, the public model appeared to be less expensive with the average labour cost per patient being 29.0% lower compared with the private model. The results suggest that a public model of service may provide a more comprehensive and less expensive interim prosthesis program for lower limb amputees.

Variable threshold algorithm for division of labor analyzed as a dynamical system.

PubMed

Castillo-Cagigal, Manuel; Matallanas, Eduardo; Navarro, Iñaki; Caamaño-Martín, Estefanía; Monasterio-Huelin, Félix; Gutiérrez, Álvaro

2014-12-01

Division of labor is a widely studied aspect of colony behavior of social insects. Division of labor models indicate how individuals distribute themselves in order to perform different tasks simultaneously. However, models that study division of labor from a dynamical system point of view cannot be found in the literature. In this paper, we define a division of labor model as a discrete-time dynamical system, in order to study the equilibrium points and their properties related to convergence and stability. By making use of this analytical model, an adaptive algorithm based on division of labor can be designed to satisfy dynamic criteria. In this way, we have designed and tested an algorithm that varies the response thresholds in order to modify the dynamic behavior of the system. This behavior modification allows the system to adapt to specific environmental and collective situations, making the algorithm a good candidate for distributed control applications. The variable threshold algorithm is based on specialization mechanisms. It is able to achieve an asymptotically stable behavior of the system in different environments and independently of the number of individuals. The algorithm has been successfully tested under several initial conditions and number of individuals.

78 FR 14487 - Tetrachlorvinphos; Proposed Extension of Time-Limited Interim Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-06

...] Tetrachlorvinphos; Proposed Extension of Time-Limited Interim Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed rule. SUMMARY: This regulation proposes the extension of the time-limited... related to EPA's extension of the time-limited interim tolerances for the combined residues of the...

78 FR 15880 - Tetrachlorvinphos; Extension of Time-Limited Interim Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-13

... Tetrachlorvinphos; Extension of Time-Limited Interim Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This regulation extends the time-limited interim tolerances for the... . II. Background A detailed summary of the background related to EPA's extension of the time-limited...

24 CFR 115.207 - Consequences of interim certification and certification.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Consequences of interim certification and certification. 115.207 Section 115.207 Housing and Urban Development Regulations Relating to... ENFORCEMENT AGENCIES Certification of Substantially Equivalent Agencies § 115.207 Consequences of interim...

46 CFR 308.203 - Amount insured under interim binder.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 8 2014-10-01 2014-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

46 CFR 308.203 - Amount insured under interim binder.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 8 2013-10-01 2013-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

46 CFR 308.203 - Amount insured under interim binder.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 8 2011-10-01 2011-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

46 CFR 308.203 - Amount insured under interim binder.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

46 CFR 308.203 - Amount insured under interim binder.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 8 2012-10-01 2012-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

76 FR 74834 - Interim Staff Guidance on Aging Management Program for Steam Generators

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

... NRC staff's evaluation of the suitability of using Revision 3 of the Nuclear Energy Institute's (NEI... NUCLEAR REGULATORY COMMISSION [NRC-2011-0228] Interim Staff Guidance on Aging Management Program for Steam Generators AGENCY: Nuclear Regulatory Commission. ACTION: Interim staff guidance; issuance...

78 FR 20503 - Energy Conservation Program: Availability of the Interim Technical Support Document for High...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-05

... Conservation Program: Availability of the Interim Technical Support Document for High-Intensity Discharge Lamps... high-intensity discharge (HID) lamps energy conservation standards in the Federal Register. This... interim analysis for high- intensity discharge lamps energy conservation standards. The notice provided...

ADP Analysis project for the Human Resources Management Division

NASA Technical Reports Server (NTRS)

Tureman, Robert L., Jr.

1993-01-01

The ADP (Automated Data Processing) Analysis Project was conducted for the Human Resources Management Division (HRMD) of NASA's Langley Research Center. The three major areas of work in the project were computer support, automated inventory analysis, and an ADP study for the Division. The goal of the computer support work was to determine automation needs of Division personnel and help them solve computing problems. The goal of automated inventory analysis was to find a way to analyze installed software and usage on a Macintosh. Finally, the ADP functional systems study for the Division was designed to assess future HRMD needs concerning ADP organization and activities.

Evaluation of the Regional Educational Laboratories. Interim Report. NCEE 2013-4014

ERIC Educational Resources Information Center

Carlson, Elaine; Scott, Jenna; Zhang, Xiaodong; Gutmann, Babette; Sinclair, Beth

2013-01-01

The Regional Educational Laboratories (RELs) are a networked system of 10 organizations that serve the educational needs of 10 designated regions across the United States and its territories. The U.S. Department of Education (ED) is authorized by the Education Sciences Reform Act (ESRA) to award contracts to 10 RELs to support applied research,…

Integrated Occupational Program: Information Manual for Administrators, Counsellors, and Teachers. Interim 1988.

ERIC Educational Resources Information Center

Forest, Jan

The Integrated Occupational Program (IOP) was designed for students in grades 8-12 who have experienced prolonged difficulty with the regular elementary and secondary school programs, who demonstrate a significant lag in one or more of their academic courses, and who typically fall into the intelligence band of 75-95 IQ. The IOP enables students…

About Looking: Vision, Transformation, and the Education of the Eye in Discourses of School Renewal Past and Present

ERIC Educational Resources Information Center

Burke, Catherine

2010-01-01

This article reports the interim findings of historical research, funded by the British Academy (2007), which is exploring the possibilities of prosopography (the study of biographies linked through a common purpose, philosophy or practice) in researching the relationship between educational thought and school design since World War Two. Through…

The Sound and Video Library: An Interim Report on an Experiment. Melanges Pedagogiques, 1976.

ERIC Educational Resources Information Center

Riley, P.; Zoppis, C.

An experimental sound- and video-library has recently been established by the Centre de Recherches et d'Applications Pedagogiques en Langues at the University of Nancy II. This article describes the functioning of the library system and gives a brief explanation of the underlying pedagogical principles which have guided the design, choice of…

Hazardous Waste Management System: Identification and Listing of Hazardous Waste - CERCLA Hazardous Substance Designation-Petroleum Refinery Primary and Other Listings (F037 and F038) - Federal Register Notice, May 13, 1991

EPA Pesticide Factsheets

The Agency is promulgating an interim final rule revising the definition of wastes subject to the F037 and F038 listings to state that sludges from non-contact, once-through cooling waters are not included.

9 CFR 92.4 - Reestablishment of a region's disease-free status.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Reestablishment of a region's disease... Reestablishment of a region's disease-free status. This section applies to regions that are designated under this subchapter as free of a specific animal disease and then experience an outbreak of that disease. (a) Interim...

An Evaluation of ESEA Title III Projects, Fiscal Year 1972. Interim Report.

ERIC Educational Resources Information Center

Wilson, Jerusa; And Others

This report contains descriptions and progress of five projects in the District of Columbia partially or wholly funded by ESEA Title III: (1) The Columbia Road Preschool Pilot Project, a second-year experimental effort designed to serve as a model school providing an experimental setting for early childhood educational programs; (2) The Montessori…

Occupational Component. 26-Level Courses. Teacher Resource Manual. Integrated Occupational Program. Interim-1991: Curriculum.

ERIC Educational Resources Information Center

Alberta Dept. of Education, Edmonton. Curriculum Branch.

This planning and instructional manual is designed to assist teachers in implementing the 20 10-credit-hour courses that make up the 26-level occupational component of the Integrated Occupational Program (IOP) in Alberta, Canada. (The IOP was developed to assist students who experience difficulties in secondary education and to help students make…

78 FR 14012 - Use of Materials Derived From Cattle in Human Food and Cosmetics; Reopening of the Comment Period

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-04

... potential risk of bovine spongiform encephalopathy (BSE) in human food, including dietary supplements, and... final rule prohibited the use of certain cattle material to address the potential risk of BSE in human... interim final rule to designate materials that could potentially contain BSE infectivity as specified risk...

The Evaluation of Oral/Aural Skills within the BA Finals Examination: Analysis and Interim Proposals.

ERIC Educational Resources Information Center

Crawshaw, Robert

An examination of the principles and techniques of oral testing in British university-level final examinations in modern languages discusses: (1) the shortcomings of present oral testing procedures; (2) the theoretical controversy surrounding the design and value of oral proficiency tests, arising from research in English as a second language…

DEBLICOM: Deaf-Blind Communication and Control Systems. Interim Progress Report, August 1974-August 1975.

ERIC Educational Resources Information Center

Kafafian, Haig

Presented is a report on the work of Cybernetics Research Institute (CRI) investigators on the development of deaf-blind communication and control systems (DEBLICOM). Described in Part One is one embodiment of DEBLICOM designed and built by CRI engineers. Reported in Part Two are experimental procedures and human factors considerations of…

Investigation of Electronic Generation of Visual Images for Air Force Technical Training. Interim Report for Period May 1974-October 1975.

ERIC Educational Resources Information Center

Filinger, Ronald H.; Hall, Paul W.

Because large scale individualized learning systems place excessive demands on conventional means of producing audiovisual software, electronic image generation has been investigated as an alternative. A prototype, experimental device, Scanimate-500, was designed and built by the Computer Image Corporation. It uses photographic, television, and…

50 CFR 259.33 - Constructive deposits and withdrawals; ratification of withdrawals (as qualified) made without...

Code of Federal Regulations, 2012 CFR

2012-10-01

... year is designated “Period (aa)”; the period between the end of a party's tax year and the party's tax...). Constructive deposits and withdrawals shall be permissible only during the Period (aa) during which a written... Period (aa), if any, which occurs before the Secretary executes the Interim CCF Agreement previously...

50 CFR 259.33 - Constructive deposits and withdrawals; ratification of withdrawals (as qualified) made without...

Code of Federal Regulations, 2013 CFR

2013-10-01

... year is designated “Period (aa)”; the period between the end of a party's tax year and the party's tax...). Constructive deposits and withdrawals shall be permissible only during the Period (aa) during which a written... Period (aa), if any, which occurs before the Secretary executes the Interim CCF Agreement previously...

50 CFR 259.33 - Constructive deposits and withdrawals; ratification of withdrawals (as qualified) made without...

Code of Federal Regulations, 2014 CFR

2014-10-01

... year is designated “Period (aa)”; the period between the end of a party's tax year and the party's tax...). Constructive deposits and withdrawals shall be permissible only during the Period (aa) during which a written... Period (aa), if any, which occurs before the Secretary executes the Interim CCF Agreement previously...

50 CFR 259.33 - Constructive deposits and withdrawals; ratification of withdrawals (as qualified) made without...

Code of Federal Regulations, 2011 CFR

2011-10-01

... year is designated “Period (aa)”; the period between the end of a party's tax year and the party's tax...). Constructive deposits and withdrawals shall be permissible only during the Period (aa) during which a written... Period (aa), if any, which occurs before the Secretary executes the Interim CCF Agreement previously...

Multiple Alternatives Modeling in Determining Fiscal Roll-Backs during Educational Funding Crises. Interim Draft. Paper and Report Series No. 70.

ERIC Educational Resources Information Center

Wholeben, Brent E.; Sullivan, John M.

This report provides an extensive discussion of the use of criterion referenced, mathematical modeling procedures to determine which budget reductions minimize reduction in the quality of educational programs. Part I, "Evaluation of Potential Budgeting Roll-backs under Educational Fiscal Crisis," explains the basic design of multiple…

Project FARE task III report : urban mass transportation industry reporting system design : interim task III report for November 1972-June 1973 period. Part I - Task summary.

DOT National Transportation Integrated Search

1973-06-01

This report contains a description of the proposed uniform reporting system for the urban mass transit industry. It is presented in four volumes: Part I - Task Summary contains a description of how Task III was accomplished and the conclusions and re...

50 CFR 259.33 - Constructive deposits and withdrawals; ratification of withdrawals (as qualified) made without...

Code of Federal Regulations, 2010 CFR

2010-10-01

... year is designated “Period (aa)”; the period between the end of a party's tax year and the party's tax...). Constructive deposits and withdrawals shall be permissible only during the Period (aa) during which a written... Period (aa), if any, which occurs before the Secretary executes the Interim CCF Agreement previously...

28 CFR 0.67 - Delegation respecting conveyances for public-airport purposes.

Code of Federal Regulations, 2010 CFR

2010-07-01

... THE DEPARTMENT OF JUSTICE Environment and Natural Resources Division § 0.67 Delegation respecting... Natural Resources Division, and such members of his staff as he may specifically designate in writing, are...

Guidelines for mission integration, a summary report

NASA Technical Reports Server (NTRS)

1979-01-01

Guidelines are presented for instrument/experiment developers concerning hardware design, flight verification, and operations and mission implementation requirements. Interface requirements between the STS and instruments/experiments are defined. Interface constraints and design guidelines are presented along with integrated payload requirements for Spacelab Missions 1, 2, and 3. Interim data are suggested for use during hardware development until more detailed information is developed when a complete mission and an integrated payload system are defined. Safety requirements, flight verification requirements, and operations procedures are defined.

Implementation Document for Other Contamination Sources Interim Response Action shell Section 36 Trenches, RMA. Volume 1. General

DTIC Science & Technology

1990-12-01

rights and obligations of theA Army as L.aaa Aqency-or Shall as Leand Party under any law or the Federai. Fact..ity (g) Unless otherwise provided in a...Exposure occurs principally during manufacture or during bulk handling activities. Since it is generally injected into the soil at depths of 15 to 30 cm...Slurry Mix Design: The design of the IMPERMIX grouting mix, which shall meet all requirements of the Impermix manufacturer . G. Quality Control Testing

ARES (Automated Residential Energy Standard) 1.2: User`s guide, in support of proposed interim energy conservation voluntary performance standards for new non-federal residential buildings: Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The ARES (Automated Residential Energy Standard) User`s Guide is designed to the user successfully operate the ARES computer program. This guide assumes that the user is familiar with basic PC skills such as using a keyboard and loading a disk drive. The ARES computer program was designed to assist building code officials in creating a residential energy standard based on local climate and costs.

The signal transduction pathways controlling in planta tuberization in potato: an emerging synthesis.

PubMed

Sarkar, Debabrata

2008-01-01

Tuberization is one of the multiple outputs of a single-input phytochrome B sensory system, involving several regulatory genes. Phytochrome B- and GA-mediated photoperiodic perception occurs in the leaf, and then the RNA acts as a systemic signal in the long-distance signaling pathway to initiate tuberization in the subapical region of an underground stolon. There is good evidence that flowering and tuberizing signals might be similar. Is there a cross-talk with an oxidative burst-mediated redox signaling pathway during tuberization? Is the lipoxygenase cascade involved in the formation of the perimedullary tissue in a growing tuber? Do aquaporins regulate cell division, expansion and elongation during stolon growth and tuber induction in potato? Is the adaptive diversity for tuberization under varying photoperiods a micro-evolutionary indicator of differential transduction of cell-to-cell signal molecules under spatial and temporal expression of regulatory genes encoding transcriptional activators? Taking these views into consideration, the review presents an interim synthesis of a signaling network regulating in planta tuberization in potato.

30 CFR 827.13 - Coal preparation plants: Interim performance standards.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Coal preparation plants: Interim performance...-COAL PREPARATION PLANTS NOT LOCATED WITHIN THE PERMIT AREA OF A MINE § 827.13 Coal preparation plants: Interim performance standards. (a) Persons operating or who have operated coal preparation plants after...

30 CFR 827.13 - Coal preparation plants: Interim performance standards.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Coal preparation plants: Interim performance...-COAL PREPARATION PLANTS NOT LOCATED WITHIN THE PERMIT AREA OF A MINE § 827.13 Coal preparation plants: Interim performance standards. (a) Persons operating or who have operated coal preparation plants after...

30 CFR 827.13 - Coal preparation plants: Interim performance standards.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Coal preparation plants: Interim performance...-COAL PREPARATION PLANTS NOT LOCATED WITHIN THE PERMIT AREA OF A MINE § 827.13 Coal preparation plants: Interim performance standards. (a) Persons operating or who have operated coal preparation plants after...

30 CFR 827.13 - Coal preparation plants: Interim performance standards.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Coal preparation plants: Interim performance...-COAL PREPARATION PLANTS NOT LOCATED WITHIN THE PERMIT AREA OF A MINE § 827.13 Coal preparation plants: Interim performance standards. (a) Persons operating or who have operated coal preparation plants after...

30 CFR 827.13 - Coal preparation plants: Interim performance standards.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Coal preparation plants: Interim performance...-COAL PREPARATION PLANTS NOT LOCATED WITHIN THE PERMIT AREA OF A MINE § 827.13 Coal preparation plants: Interim performance standards. (a) Persons operating or who have operated coal preparation plants after...

75 FR 13484 - Foreign-Trade Zone 22; Temporary/Interim Manufacturing Authority; LG Electronics Mobilecomm USA...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-22

... DEPARTMENT OF COMMERCE [Docket T-1-2010] Foreign-Trade Zones Board Foreign-Trade Zone 22; Temporary/Interim Manufacturing Authority; LG Electronics Mobilecomm USA, Inc. (Cell Phones); Notice of.../ interim manufacturing (T/IM) authority, on behalf of LG Electronics Mobilecomm USA, Inc. (LGEMU), to...

76 FR 37781 - Foreign-Trade Zone 26; Atlanta, GA; Application for Temporary/Interim Manufacturing Authority...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-28

..., GA; Application for Temporary/ Interim Manufacturing Authority; Makita Corporation of America; (Hand- Held Power Tool and Gasoline/Electric-Powered Garden Product Manufacturing); Buford, GA An application... Georgia Foreign-Trade Zone, Inc., grantee of FTZ 26, requesting temporary/interim manufacturing (T/IM...

Interim Action Proposed Plan for the Chemicals, Metals, and Pesticides (CMP) Pits Operable Unit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bradley, J.

2002-06-18

The purpose of this Interim Action Proposed Plan (IAPP) is to describe the preferred interim remedial action for addressing the Chemicals, Metals, and Pesticides (CMP) Pits Operable Unit and to provide an opportunity for public input into the remedial action selection process.

The Intentional Interim

ERIC Educational Resources Information Center

Nugent, Patricia A.

2011-01-01

The author spent years in central-office administration, most recently in an interim position. Some interim administrators simply see themselves as placeholders until the real deal is hired, giving the organization the opportunity to coast. There are others who see themselves as change agents and cannot wait to undo or redo what their predecessor…

Presidential Transition: The Experience of Two Community College Interim Presidents

ERIC Educational Resources Information Center

Thompson, Matthew D.

2010-01-01

The purpose of this qualitative case study was to understand the experiences of two community college interim presidents, their characteristics, and how they led institutions following an abrupt presidential departure. There were two fundamental questions framing this research study, 1. How do two interim community college presidents lead…

47 CFR 73.404 - Interim hybrid IBOC DAB operation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... RADIO BROADCAST SERVICES Digital Audio Broadcasting § 73.404 Interim hybrid IBOC DAB operation. (a) The... test operation pursuant to § 73.1620, may commence interim hybrid IBOC DAB operation with digital... No. 99-325. FM stations are permitted to operate with hybrid digital effective radiated power equal...

17 CFR 210.10-01 - Interim financial statements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... accountant on the review must be filed with the interim financial statements. (e) Filing of other interim... sheets shall include only major captions (i.e., numbered captions) prescribed by the applicable sections... the date of any material accounting change and the reasons for making it. In addition, for filings on...

77 FR 55232 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2012-03; Compliance With...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-07

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0067] Japan Lessons-Learned Project Directorate Interim...-Learned Project Directorate Interim Staff Guidance; issuance. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or the Commission) is issuing the Final Japan Lessons-Learned Project Directorate (JLD...

78 FR 40199 - Draft Spent Fuel Storage and Transportation Interim Staff Guidance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... NUCLEAR REGULATORY COMMISSION [NRC-2013-0140] Draft Spent Fuel Storage and Transportation Interim... Spent Fuel Storage and Transportation Interim Staff Guidance No. 24 (SFST-ISG-24), Revision 0, ``The Use of a Demonstration Program as Confirmation of Integrity for Continued Storage of High Burnup Fuel...

75 FR 66553 - Truth in Lending

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-28

... AGENCY: Board of Governors of the Federal Reserve System. ACTION: Interim final rule; request for public comment. SUMMARY: The Board is publishing for public comment an interim final rule amending Regulation Z (Truth in Lending). The interim rule implements Section 129E of the Truth in Lending Act (TILA), which...

Staff Reactions to Interim Leadership in a Student Affairs Organization

ERIC Educational Resources Information Center

Jones, Robin D.

2011-01-01

Interim leadership appointments in higher education are a common strategy used to fill leadership gaps in executive positions. Because student affairs executives are particularly vulnerable to high turnover rates, interim appointments are becoming more widespread. Even with the prevalence of this trend, little attention has been given to the…

Faculty and Student Views of the Interim Term

ERIC Educational Resources Information Center

Centra, John A.; Sobol, Marion G.

1974-01-01

Evaluations of the interim term or 4-1-4 program at various colleges have been generally favorable. A detailed evaluation of the Rider College interim study program based on faculty and student reports indicated that the more nontraditionally oriented courses were rated higher than the more traditional offerings. (Editor/PG)

12 CFR 541.18 - Interim Federal savings association.

Code of Federal Regulations, 2010 CFR

2010-01-01

... an existing savings and loan holding company or to facilitate any other transaction the Office may... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Interim Federal savings association. 541.18... REGULATIONS AFFECTING FEDERAL SAVINGS ASSOCIATIONS § 541.18 Interim Federal savings association. The term...

15 CFR 904.322 - Interim action.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Interim action. 904.322 Section 904... Sanctions and Denials Permit Sanction for Violations § 904.322 Interim action. (a) To protect marine resources during the pendency of an action under this subpart, in cases of willfulness, or as otherwise...

15 CFR 904.322 - Interim action.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Interim action. 904.322 Section 904... Sanctions and Denials Permit Sanction for Violations § 904.322 Interim action. (a) To protect marine resources during the pendency of an action under this subpart, in cases of willfulness, or as otherwise...

Into the Sunset: Reflections of an Interim Administrator.

ERIC Educational Resources Information Center

Marlowe, John

2000-01-01

One advantage to an interim administrative position is that the public cuts short-timers a little slack. Temporary administrators can learn on the job and become experts on specialized subjects. Personnel issues demand more time than interims possess. Such positions usually do not turn into long-term contracts. (MLH)

PCoD Lite - Using an Interim PCoD Protocol to Assess the Effects of Disturbance Associated with US Navy Exercises on Marine Mammal Populations

DTIC Science & Technology

2015-09-30

1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. PCoD Lite - Using an Interim PCoD Protocol to Assess...US National Research Council (NRC 2005). Here, we provide an insight into how the Interim PCoD approach (Harwood et al. 2014, King et al. 2015...illustrate how the interim PCoD protocol can be used to inform the process of determining whether or not Navy activities are likely to have an impact on

Energy efficient flexible hybrid wavelength division multiplexing-time division multiplexing passive optical network with pay as you grow deployment

NASA Astrophysics Data System (ADS)

Garg, Amit Kumar; Madavi, Amresh Ashok; Janyani, Vijay

2017-02-01

A flexible hybrid wavelength division multiplexing-time division multiplexing passive optical network architecture that allows dual rate signals to be sent at 1 and 10 Gbps to each optical networking unit depending upon the traffic load is proposed. The proposed design allows dynamic wavelength allocation with pay-as-you-grow deployment capability. This architecture is capable of providing up to 40 Gbps of equal data rates to all optical distribution networks (ODNs) and up to 70 Gbps of a asymmetrical data rate to the specific ODN. The proposed design handles broadcasting capability with simultaneous point-to-point transmission, which further reduces energy consumption. In this architecture, each module sends a wavelength to each ODN, thus making the architecture fully flexible; this flexibility allows network providers to use only required OLT components and switch off others. The design is also reliable to any module or TRx failure and provides services without any service disruption. Dynamic wavelength allocation and pay-as-you-grow deployment support network extensibility and bandwidth scalability to handle future generation access networks.

A Survivable Wavelength Division Multiplexing Passive Optical Network with Both Point-to-Point Service and Broadcast Service Delivery

NASA Astrophysics Data System (ADS)

Ma, Xuejiao; Gan, Chaoqin; Deng, Shiqi; Huang, Yan

2011-11-01

A survivable wavelength division multiplexing passive optical network enabling both point-to-point service and broadcast service is presented and demonstrated. This architecture provides an automatic traffic recovery against feeder and distribution fiber link failure, respectively. In addition, it also simplifies the protection design for multiple services transmission in wavelength division multiplexing passive optical networks.