Development of 3D Ice Accretion Measurement Method

NASA Technical Reports Server (NTRS)

Lee, Sam; Broeren, Andy P.; Addy, Harold E., Jr.; Sills, Robert; Pifer, Ellen M.

2012-01-01

Icing wind tunnels are designed to simulate in-flight icing environments. The chief product of such facilities is the ice accretion that forms on various test articles. Documentation of the resulting ice accretion key piece of data in icing-wind-tunnel tests. Number of currently used options for documenting ice accretion in icing-wind-tunnel testing.

Apparel, Baking, Laundry and Dry Cleaning, and Textile Mill Products Industries. Reprinted from the Occupational Outlook Handbook, 1978-79 Edition.

ERIC Educational Resources Information Center

Bureau of Labor Statistics (DOL), Washington, DC.

Focusing on occupations in the clothing and baking industries, this document is one in a series of forty-one reprints from the Occupational Outlook Handbook providing current information and employment projections for individual occupations and industries through 1985. The specific occupations covered in this document include occupations in the…

An Application of Mathematical Programming to Assess Managerial Efficiency in the Houston Independent School District

DTIC Science & Technology

1981-11-01

documenting attempts to define production functions in education. Levin 2 and Hanushek characterize current methodologies as being deficient both concept- ually...Evaluation and Policy Analysis, 2, 1, (1980), 27-36. 16. Hanushek , E. A., "Conceptual and Empirical Issues in Lstimation of Educational Production

76 FR 10667 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-25

... a currently approved collection. Title: Notice of Release of Tobacco Products, Cigarette Papers, or Cigarette Tubes. Form: TTB F 5200.11 Abstract: The form documents the release of tobacco products and cigarette papers and tubes from Customs custody, and return of such articles, to a manufacturer or export...

78 FR 49723 - Humboldt-Toiyabe National Forests; Ely Ranger District; Ely Westside Rangeland Project

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-15

... Month (AUM) production for the Humboldt National Forest while improving the gap between existing and...: 1. Current Management Alternative: Continue current grazing management. 2. No Grazing Alternative... documents. (Authority: 40 CFR 1501.7 and 1508.22; Forest Service Handbook 1909.15, Section 21) Dated: August...

Functions and requirements document for interim store solidified high-level and transuranic waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith-Fewell, M.A., Westinghouse Hanford

1996-05-17

The functions, requirements, interfaces, and architectures contained within the Functions and Requirements (F{ampersand}R) Document are based on the information currently contained within the TWRS Functions and Requirements database. The database also documents the set of technically defensible functions and requirements associated with the solidified waste interim storage mission.The F{ampersand}R Document provides a snapshot in time of the technical baseline for the project. The F{ampersand}R document is the product of functional analysis, requirements allocation and architectural structure definition. The technical baseline described in this document is traceable to the TWRS function 4.2.4.1, Interim Store Solidified Waste, and its related requirements, architecture,more » and interfaces.« less

Social Sciences in Forestry, A Current Selected Bibliography, No. 55, June 1981.

ERIC Educational Resources Information Center

Schwab, Judith L., Ed.

Documents which address the interface between forestry and the social sciences comprise this annotated bibliography. The publications described are grouped under five headings: (1) social science applied to forestry at large; (2) applied to forestry's productive agents; (3) applied to forest production; (4) applied to manufacturing; and (5)…

Moderate Resolution Imaging Spectroradiometer (MODIS) MOD21 Land Surface Temperature and Emissivity Algorithm Theoretical Basis Document

NASA Technical Reports Server (NTRS)

Hulley, G.; Malakar, N.; Hughes, T.; Islam, T.; Hook, S.

2016-01-01

This document outlines the theory and methodology for generating the Moderate Resolution Imaging Spectroradiometer (MODIS) Level-2 daily daytime and nighttime 1-km land surface temperature (LST) and emissivity product using the Temperature Emissivity Separation (TES) algorithm. The MODIS-TES (MOD21_L2) product, will include the LST and emissivity for three MODIS thermal infrared (TIR) bands 29, 31, and 32, and will be generated for data from the NASA-EOS AM and PM platforms. This is version 1.0 of the ATBD and the goal is maintain a 'living' version of this document with changes made when necessary. The current standard baseline MODIS LST products (MOD11*) are derived from the generalized split-window (SW) algorithm (Wan and Dozier 1996), which produces a 1-km LST product and two classification-based emissivities for bands 31 and 32; and a physics-based day/night algorithm (Wan and Li 1997), which produces a 5-km (C4) and 6-km (C5) LST product and emissivity for seven MODIS bands: 20, 22, 23, 29, 31-33.

Energy Product Options for Eucalyptus Species Grown as Short Rotation Woody Crops

PubMed Central

Rockwood, Donald L.; Rudie, Alan W.; Ralph, Sally A.; Zhu, J.Y.; Winandy, Jerrold E.

2008-01-01

Eucalyptus species are native to Australia but grown extensively worldwide as short rotation hardwoods for a variety of products and as ornamentals. We describe their general importance with specific emphasis on existing and emerging markets as energy products and the potential to maximize their productivity as short rotation woody crops. Using experience in Florida USA and similar locations, we document their current energy applications and assess their productivity as short-term and likely long-term energy and related products. PMID:19325808

Secret science: tobacco industry research on smoking behaviour and cigarette toxicity.

PubMed

Hammond, David; Collishaw, Neil E; Callard, Cynthia

2006-03-04

A lack of scientific data remains the principal obstacle to regulating cigarette toxicity. In particular, there is an immediate need to improve our understanding of the interaction between smoking behaviour and product design, and its influence on cigarette deliveries. This article reviews internal tobacco industry documents on smoking behaviour research undertaken by Imperial Tobacco Limited (ITL) and British-American Tobacco (BAT). BAT documents indicate that smokers vary their puffing behaviour to regulate nicotine levels and compensate for low-yield cigarettes by smoking them more intensely. BAT research also shows that the tar and nicotine delivered to smokers is substantially greater than the machine-smoked yields reported to consumers and regulators. Internal documents describe a strategy to maximise this discrepancy through product design. In particular, BAT developed elastic cigarettes that produced low yields under standard testing protocols, whereas in consumers' hands they elicited more intensive smoking and provided higher concentrations of tar and nicotine to smokers. Documents also show that BAT pursued this product strategy despite the health risks to consumers and ethical concerns raised by senior scientists, and paired it with an equally successful marketing campaign that promoted these cigarettes as low-tar alternatives for health-concerned smokers. Overall, the documents seem to reveal a product strategy intended to exploit the limitations of the testing protocols and to intentionally conceal from consumers and regulators the potential toxicity of BAT products revealed by BAT's own research. Tobacco industry research underscores the serious limitations of the current cigarette testing protocols and the documents describe deceptive business practices that remain in place.

Automated documentation generator for advanced protein crystal growth

NASA Technical Reports Server (NTRS)

Maddux, Gary A.; Provancha, Anna; Chattam, David; Ford, Ronald

1993-01-01

The System Management and Production Laboratory at the Research Institute, the University of Alabama in Huntsville (UAH), was tasked by the Microgravity Experiment Projects (MEP) Office of the Payload Projects Office (PPO) at Marshall Space Flight Center (MSFC) to conduct research in the current methods of written documentation control and retrieval. The goals of this research were to determine the logical interrelationships within selected NASA documentation, and to expand on a previously developed prototype system to deliver a distributable, electronic knowledge-based system. This computer application would then be used to provide a paperless interface between the appropriate parties for the required NASA document.

Computer-assisted technologies used in oral rehabilitation and the clinical documentation of alleged advantages - a systematic review.

PubMed

Jokstad, A

2017-04-01

The objective of this systematic review is to identify current computer-assisted technologies used for managing patients with a need to re-establish craniofacial appearance, subjective discomfort and stomatognathic function, and the extent of their clinical documentation. Electronic search strategies were used for locating clinical studies in MEDLINE through PubMed and in the Cochrane library, and in the grey literature through searches on Google Scholar. The searches for commercial digital products for use in oral rehabilitation resulted in identifying 225 products per November 2016, used for patient diagnostics, communication and therapy purposes, and for other computer-assisted applications in context with oral rehabilitation. About one-third of these products were described in about 350 papers reporting from clinical human studies. The great majority of digital products for use in oral rehabilitation has no clinical documentation at all, while the products from a distinct minority of manufacturers have frequently appeared in more or less scientific reports. Moore's law apply also to digital dentistry, which predicts that the capacity of microprocessors will continue to become faster and with lower cost per performance unit, and innovative software programs will harness these improvements in performance. The net effect is the noticeable short product life cycle of digital products developed for use in oral rehabilitation and often lack of supportive clinical documentation. Nonetheless, clinicians must request clinically meaningful information about new digital products to assess net benefits for the patients or the dental professionals and not accept only technological verbiage as a basis for product purchases. © 2017 John Wiley & Sons Ltd.

The Database Business: Managing Today--Planning for Tomorrow. Profiting with New Products and Services.

ERIC Educational Resources Information Center

Berger, Mary C.; Bourne, Charles P.

1988-01-01

The first paper discusses the factors involved in a decision to provide document delivery services, including user needs, competitive climate, business potential, fit with current business, and logistics of providing the service. The second reviews the kinds of additional products that can be developed as a byproduct of conventional database…

78 FR 70306 - Distribution of In Vitro Diagnostic Products Labeled for Research Use Only or Investigational Use...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-25

... for Devices and Radiological Health (CDRH) Food and Drug Administration, 10903 New Hampshire Ave...''). This guidance is intended to provide the current thinking of CDRH and CBER on when IVD products are... capability for all CDRH guidance documents is available at http://www.fda.gov/MedicalDevices/Device...

Effect of policies on pellet production and forests in the U.S. South: a technical document supporting the Forest Service update of the 2010 RPA Assessment

Treesearch

Karen L. Abt; Robert C. Abt; Christopher S. Galik; Kenneth E. Skog

2014-01-01

Current policies in the European Union (EU) requiring renewable and low greenhouse gas-emitting energy are affecting wood products manufacturing and forests in the United States. These policies have led to increased U.S. pellet production and export to the EU, which has in turn affected U.S. forests and other wood products manufacturing. At this time, the primary...

The match between institutional elderly care management research and management challenges - a systematic literature review.

PubMed

Kokkonen, Kaija; Rissanen, Sari; Hujala, Anneli

2012-11-08

Elderly care practice and its management together with policy and research play a crucial role in responding to increasing challenges in institutional care for elderly people. Successful dialogue between these is necessary. The purpose of this systematic literature review is to compare how institutional elderly care management research meets the care challenges currently emphasized in international long-term care policy documents. This paper was based on a systematic literature review. After screening 1971 abstracts using inclusion/exclusion criteria, 58 refereed articles published between 2000 and 2010 remained for analysis. The articles were analyzed using theory-based content analysis by comparing the results to the framework based on analysis of international long-term care management policy documents. The current challenges of long-term care management identified from policy documents were Integrated Care Management, Productivity Management, Quality Management, Workforce Management and ICT Management. The research on institutional elderly care management responded somewhat to the challenges mentioned in policy documents. However, some of the challenges were studied broadly and some were paid only minor attention. Further, only few studies focused on the core items of challenges addressed in policy documents. Institutional care management research needs to focus more on challenges in integrated care, productivity, ICT and division of labor. Managers, researchers and policy-makers should assume more active collaborative roles in processes of research, policymaking and policy implementation. In addition managers' and policymakers' scientific literacy needs to be enhanced.

The match between institutional elderly care management research and management challenges - a systematic literature review

PubMed Central

2012-01-01

Background Elderly care practice and its management together with policy and research play a crucial role in responding to increasing challenges in institutional care for elderly people. Successful dialogue between these is necessary. The purpose of this systematic literature review is to compare how institutional elderly care management research meets the care challenges currently emphasized in international long-term care policy documents. Methods This paper was based on a systematic literature review. After screening 1971 abstracts using inclusion/exclusion criteria, 58 refereed articles published between 2000 and 2010 remained for analysis. The articles were analyzed using theory-based content analysis by comparing the results to the framework based on analysis of international long-term care management policy documents. Results The current challenges of long-term care management identified from policy documents were Integrated Care Management, Productivity Management, Quality Management, Workforce Management and ICT Management. The research on institutional elderly care management responded somewhat to the challenges mentioned in policy documents. However, some of the challenges were studied broadly and some were paid only minor attention. Further, only few studies focused on the core items of challenges addressed in policy documents. Conclusions Institutional care management research needs to focus more on challenges in integrated care, productivity, ICT and division of labor. Managers, researchers and policy-makers should assume more active collaborative roles in processes of research, policymaking and policy implementation. In addition managers’ and policymakers’ scientific literacy needs to be enhanced. PMID:23137416

Naucno-tehnicka kultura i proizvodno-tehnicko stavaralastvo u Jugoslaviji (Scientific and Technical Culture and Productive Technical Creativity in Yugoslavia).

ERIC Educational Resources Information Center

Federation of Yugoslav Organizations for Technical Culture, Belgrade.

This document is an English-language abstract (approximately 1,500 words) of a book prepared by the Federation of Yugoslavia Organizations for Technical Culture ("Narodna Tehnika"). In this book, an attempt is made to (1) establish the current trends in the development of scientific and technical culture and productive technical…

International petroleum statistics report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-11-01

This document is a monthly publication which provides current data on international oil production,demand,imports and stocks. This report has four sections which contain time series data on world oil production and oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). Also included is oil supply/demand balance information for the world, and data on oil imports and trade by OECD countries.

Health impacts of anthropogenic biomass burning in the developed world.

PubMed

Sigsgaard, Torben; Forsberg, Bertil; Annesi-Maesano, Isabella; Blomberg, Anders; Bølling, Anette; Boman, Christoffer; Bønløkke, Jakob; Brauer, Michael; Bruce, Nigel; Héroux, Marie-Eve; Hirvonen, Maija-Riitta; Kelly, Frank; Künzli, Nino; Lundbäck, Bo; Moshammer, Hanns; Noonan, Curtis; Pagels, Joachim; Sallsten, Gerd; Sculier, Jean-Paul; Brunekreef, Bert

2015-12-01

Climate change policies have stimulated a shift towards renewable energy sources such as biomass. The economic crisis of 2008 has also increased the practice of household biomass burning as it is often cheaper than using oil, gas or electricity for heating. As a result, household biomass combustion is becoming an important source of air pollutants in the European Union.This position paper discusses the contribution of biomass combustion to pollution levels in Europe, and the emerging evidence on the adverse health effects of biomass combustion products.Epidemiological studies in the developed world have documented associations between indoor and outdoor exposure to biomass combustion products and a range of adverse health effects. A conservative estimate of the current contribution of biomass smoke to premature mortality in Europe amounts to at least 40 000 deaths per year.We conclude that emissions from current biomass combustion products negatively affect respiratory and, possibly, cardiovascular health in Europe. Biomass combustion emissions, in contrast to emissions from most other sources of air pollution, are increasing. More needs to be done to further document the health effects of biomass combustion in Europe, and to reduce emissions of harmful biomass combustion products to protect public health. Copyright ©ERS 2015.

Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weakley, Steven A.

The purpose of the project described in this report is to identify and document the commercial and emerging (projected to be commercialized within the next 3 years) hydrogen and fuel cell technologies and products that resulted from Department of Energy support through the Fuel Cell Technologies (FCT) Program in the Office of Energy Efficiency and Renewable Energy (EERE). Pacific Northwest National Laboratory (PNNL) undertook two efforts simultaneously to accomplish this project. The first effort was a patent search and analysis to identify patents related to hydrogen and fuel cells that are associated with FCT-funded projects (or projects conducted by DOE-EEREmore » predecessor programs) and to ascertain the patents’ current status, as well as any commercial products that may have used the technology documented in the patent. The second effort was a series of interviews with current and past FCT personnel, a review of relevant program annual reports, and an examination of grants made under the Small Business Innovation Research and Small Business Technology Transfer Programs that are related to hydrogen and fuel cells.« less

Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weakley, Steven A.; Brown, Scott A.

The purpose of the project described in this report is to identify and document the commercial and emerging (projected to be commercialized within the next 3 years) hydrogen and fuel cell technologies and products that resulted from Department of Energy support through the Fuel Cell Technologies (FCT) Program in the Office of Energy Efficiency and Renewable Energy (EERE). To do this, Pacific Northwest National Laboratory (PNNL) undertook two efforts simultaneously to accomplish this project. The first effort was a patent search and analysis to identify hydrogen- and fuel-cell-related patents that are associated with FCT-funded projects (or projects conducted by DOE-EEREmore » predecessor programs) and to ascertain the patents current status, as well as any commercial products that may have used the technology documented in the patent. The second effort was a series of interviews with current and past FCT personnel, a review of relevant program annual reports, and an examination of hydrogen- and fuel-cell-related grants made under the Small Business Innovation Research and Small Business Technology Transfer Programs, and within the FCT portfolio.« less

Medical Grade Water Generation for Intravenous Fluid Production on Exploration Missions

NASA Technical Reports Server (NTRS)

Niederhaus, Charles E.; Barlow, Karen L.; Griffin, DeVon W.; Miller, Fletcher J.

2008-01-01

This document describes the intravenous (IV) fluids requirements for medical care during NASA s future Exploration class missions. It further discusses potential methods for generating such fluids and the challenges associated with different fluid generation technologies. The current Exploration baseline mission profiles are introduced, potential medical conditions described and evaluated for fluidic needs, and operational issues assessed. Conclusions on the fluid volume requirements are presented, and the feasibility of various fluid generation options are discussed. A separate report will document a more complete trade study on the options to provide the required fluids.At the time this document was developed, NASA had not yet determined requirements for medical care during Exploration missions. As a result, this study was based on the current requirements for care onboard the International Space Station (ISS). While we expect that medical requirements will be different for Exploration missions, this document will provide a useful baseline for not only developing hardware to generate medical water for injection (WFI), but as a foundation for meeting future requirements. As a final note, we expect WFI requirements for Exploration will be higher than for ISS care, and system capacity may well need to be higher than currently specified.

Comparing two botulinum toxin type A formulations using manufacturers' product summaries.

PubMed

Wenzel, R; Jones, D; Borrego, J A

2007-08-01

Because of the unique pharmacology and clinical versatility of botulinum toxin (BoNT), particularly BoNT serotype A (BoNTA), a need exists for discussion of the current data on similarities and differences between two BoNTA products, BOTOX and Dysport. We compared the physiochemical and pharmacological properties of BOTOX and Dysport using information from the Summary of Product Characteristics (SmPC) documents from a number of countries around the world. Our analysis based on the SmPC documents demonstrated distinct differences in physical characteristics, breadth of approved indications, dosing and administration, and the incidence and severity of adverse events. BOTOX and Dysport are not bioequivalent. Many of the differences between BOTOX and Dysport discussed within are probably related to the differences in their physical characteristics.

Using resources for scientific-driven pharmacovigilance: from many product safety documents to one product safety master file.

PubMed

Furlan, Giovanni

2012-08-01

Current regulations require a description of the overall safety profile or the specific risks of a drug in multiple documents such as the Periodic and Development Safety Update Reports, Risk Management Plans (RMPs) and Signal Detection Reports. In a resource-constrained world, the need for preparing multiple documents reporting the same information results in shifting the focus from a thorough scientific and medical evaluation of the available data to maintaining compliance with regulatory timelines. Since the aim of drug safety is to understand and characterize product issues to take adequate risk minimization measures rather than to comply with bureaucratic requirements, there is the need to avoid redundancy. In order to identify core drug safety activities that need to be undertaken to protect patient safety and reduce the number of documents reporting the results of these activities, the author has reviewed the main topics included in the drug safety guidelines and templates. The topics and sources that need to be taken into account in the main regulatory documents have been found to greatly overlap and, in the future, as a result of the new Periodic Safety Update Report structure and requirements, in the author's opinion this overlap is likely to further increase. Many of the identified inter-document differences seemed to be substantially formal. The Development Safety Update Report, for example, requires separate presentation of the safety issues emerging from different sources followed by an overall evaluation of each safety issue. The RMP, instead, requires a detailed description of the safety issues without separate presentation of the evidence derived from each source. To some extent, however, the individual documents require an in-depth analysis of different aspects; the RMP, for example, requires an epidemiological description of the indication for which the drug is used and its risks. At the time of writing this article, this is not specifically required by other documents. The author has identified signal detection (intended not only as adverse event disproportionate reporting, but including non-clinical, laboratory, clinical analysis data and literature screening) and characterization as the basis for the preparation of all drug safety documents, which can be viewed as different ways of presenting the results of this activity. Therefore, the author proposes to merge all the aggregate reports required by current regulations into a single document - the Drug Safety Master File. This report should contain all the available information, from any source, regarding the potential and identified risks of a drug. It should be a living document updated and submitted to regulatory authorities on an ongoing basis.

ENVIRONMENTAL REGULATIONS AND TECHNOLOGY: USE AND DISPOSAL OF MUNICIPAL WASTEWATER SLUDGE

EPA Science Inventory

The document describes the five major sludge use/disposal options currently available--land application, distribution and marketing of sludge products, land-filling, incineration, and ocean disposal--and factors influencing their selection and implementation. It also provides an ...

77 FR 31564 - Notice of Availability of a Treatment Evaluation Document; Methyl Bromide Fumigation of Cottonseed

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

... significant impacts on U.S. cotton production. They are currently found only in Australia. Fumigation with methyl bromide was the only approved treatment for FOV VCG 01111 and 01112, so when the Environmental...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dale, Gregory E.

There is currently a serious shortage of 99Mo, from which to generate the medically significant isotope 99mTc. Most of the world's supply comes from the fission of highly enriched uranium targets--this is a proliferation concern. This document focuses on the technology involved in two alternative methods: electron accelerator production of 99Mo from the 100Mo(γ,n) 99Mo reaction and production of 99Mo as a fission product in a subcritical, DT accelerator-driven low enriched uranium salt solution.

SIMBIOS Project

NASA Technical Reports Server (NTRS)

Fargion, Giulietta S.; McClain, Charles R.; Busalacchi, Antonio J. (Technical Monitor)

2001-01-01

The purpose of this technical report is to provide current documentation of the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project activities, NASA Research Announcement (NRAI) research status, satellite data processing, data product validation, and field calibration. This documentation is necessary to ensure that critical information is related to the scientific community and NASA management. This critical information includes the technical difficulties and challenges of validating and combining ocean color data from an array of independent satellite systems to form consistent and accurate global bio-optical time series products. This technical report is not meant as a substitute for scientific literature. Instead, it will provide a ready and responsive vehicle for the multitude of technical reports issued by an operational project.

Status summary of chemical processing development in plutonium-238 supply program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, Emory D.; Benker, Dennis; Wham, Robert M.

This document summarizes the status of development of chemical processing in the Plutonium-238 Supply Program (PSP) near the end of Demonstration 1. The objective of the PSP is “to develop, demonstrate, and document a production process that meets program objectives and to prepare for its operation” (Frazier et al. 2016). Success in the effort includes establishing capability using the current infrastructure to produce Np targets for irradiation in Department of Energy research reactors, chemically processing the irradiated targets to separate and purify the produced Pu and transferring the PuO 2 product to Los Alamos National Laboratory (LANL) at an averagemore » rate of 1.5 kg/y.« less

Sources of Variability in Chlorophyll Analysis by Fluorometry and High-Performance Liquid Chromatography in a SIMBIOS Inter-Calibration Exercise

NASA Technical Reports Server (NTRS)

VanHeukelem, Laurie; Thomas, Crystal S.; Gilbert, Patricia M.; Fargion, Giulietta S. (Editor); McClain, Charles R. (Editor)

2002-01-01

The purpose of this technical report is to provide current documentation of the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project activities, NASA Research Announcement (NRA) research status, satellite data processing, data product validation, and field calibration. This documentation is necessary to ensure that critical information is related to the scientific community and NASA management. This critical information includes the technical difficulties and challenges of validating and combining ocean color data from an array of independent satellite systems to form consistent and accurate global bio-optical time series products. This technical report is not meant as a substitute for scientific literature. Instead, it will provide a ready and responsive vehicle for the multitude of technical reports issued by an operational project. This particular document focus on the variability in chlorophyll pigment measurements resulting from differences in methodologies and laboratories conducting the pigment analysis.

Advanced Q-switched DPSS lasers for ID-card marking

NASA Astrophysics Data System (ADS)

Hertwig, Michael; Paster, Martin; Terbrueggen, Ralf

2008-02-01

Increased homeland security concerns across the world have generated a strong demand for forgery-proof ID documents. Manufacturers currently employ a variety of high technology techniques to produce documents that are difficult to copy. However, production costs and lead times are still a concern when considering any possible manufacturing technology. Laser marking has already emerged as an important tool in the manufacturer's arsenal, and is currently being utilized to produce a variety of documents, such as plastic ID cards, drivers' licenses, health insurance cards and passports. The marks utilized can range from simple barcodes and text to high resolution, true grayscale images. The technical challenges posed by these marking tasks include delivering adequate mark legibility, minimizing substrate burning or charring, accurately reproducing grayscale data, and supporting the required process throughput. This article covers the advantages and basic requirements on laser marking of cards and reviews how laser output parameters affect marking quality, speed and overall process economics.

State-Specific Prevalence of Tobacco Product Use Among Adults - United States, 2014-2015.

PubMed

Odani, Satomi; Armour, Brian S; Graffunder, Corinne M; Willis, Gordon; Hartman, Anne M; Agaku, Israel T

2018-01-26

Despite recent declines in cigarette smoking prevalence, the tobacco product landscape has shifted to include emerging tobacco products* (1,2). Previous research has documented adult use of smokeless tobacco and cigarettes by state (3); however, state-specific data on other tobacco products are limited. To assess tobacco product use in the 50 U.S. states and the District of Columbia (DC), CDC and the National Cancer Institute analyzed self-reported use of six tobacco product types: cigarettes, cigars, regular pipes, water pipes, electronic cigarettes (e-cigarettes), and smokeless tobacco products among adults aged ≥18 years using data from the 2014-2015 Tobacco Use Supplement to the Current Population Survey (TUS-CPS). Prevalence of ever-use of any tobacco product ranged from 27.0% (Utah) to 55.4% (Wyoming). Current (every day or some days) use of any tobacco product ranged from 10.2% (California) to 27.7% (Wyoming). Cigarettes were the most common currently used tobacco product in all states and DC. Among current cigarette smokers, the proportion who currently used one or more other tobacco products ranged from 11.5% (Delaware) to 32.3% (Oregon). Differences in tobacco product use across states underscore the importance of implementing proven population-level strategies to reduce tobacco use and expanding these strategies to cover all forms of tobacco marketed in the United States. Such strategies could include comprehensive smoke-free policies, tobacco product price increases, anti-tobacco mass media campaigns, and barrier-free access to clinical smoking cessation resources (1,4).

Soil agroecosystem health: current challenges and future opportunities

USDA-ARS?s Scientific Manuscript database

Soil health is a broad concept that emphasizes the ecological importance of soils, including sustained plant and animal productivity, human health, and environmental quality. In the United States, soil degradation and associated water quality problems have been widely documented. Improvement and mai...

Metadata and Service at the GFZ ISDC Portal

NASA Astrophysics Data System (ADS)

Ritschel, B.

2008-05-01

The online service portal of the GFZ Potsdam Information System and Data Center (ISDC) is an access point for all manner of geoscientific geodata, its corresponding metadata, scientific documentation and software tools. At present almost 2000 national and international users and user groups have the opportunity to request Earth science data from a portfolio of 275 different products types and more than 20 Million single data files with an added volume of approximately 12 TByte. The majority of the data and information, the portal currently offers to the public, are global geomonitoring products such as satellite orbit and Earth gravity field data as well as geomagnetic and atmospheric data for the exploration. These products for Earths changing system are provided via state-of-the art retrieval techniques. The data product catalog system behind these techniques is based on the extensive usage of standardized metadata, which are describing the different geoscientific product types and data products in an uniform way. Where as all ISDC product types are specified by NASA's Directory Interchange Format (DIF), Version 9.0 Parent XML DIF metadata files, the individual data files are described by extended DIF metadata documents. Depending on the beginning of the scientific project, one part of data files are described by extended DIF, Version 6 metadata documents and the other part are specified by data Child XML DIF metadata documents. Both, the product type dependent parent DIF metadata documents and the data file dependent child DIF metadata documents are derived from a base-DIF.xsd xml schema file. The ISDC metadata philosophy defines a geoscientific product as a package consisting of mostly one or sometimes more than one data file plus one extended DIF metadata file. Because NASA's DIF metadata standard has been developed in order to specify a collection of data only, the extension of the DIF standard consists of new and specific attributes, which are necessary for an explicit identification of single data files and the set-up of a comprehensive Earth science data catalog. The huge ISDC data catalog is realized by product type dependent tables filled with data file related metadata, which have relations to corresponding metadata tables. The product type describing parent DIF XML metadata documents are stored and managed in ORACLE's XML storage structures. In order to improve the interoperability of the ISDC service portal, the existing proprietary catalog system will be extended by an ISO 19115 based web catalog service. In addition to this development there is ISDC related concerning semantic network of different kind of metadata resources, like different kind of standardized and not-standardized metadata documents and literature as well as Web 2.0 user generated information derived from tagging activities and social navigation data.

Global Precipitation Measurement (GPM) Mission Products and Services at the NASA Goddard Earth Sciences Data and Information Services Center (GES DISC)

NASA Technical Reports Server (NTRS)

Liu, Z.; Ostrenga, D.; Vollmer, B.; Kempler, S.; Deshong, B.; Greene, M.

2015-01-01

The NASA Goddard Earth Sciences (GES) Data and Information Services Center (DISC) hosts and distributes GPM data within the NASA Earth Observation System Data Information System (EOSDIS). The GES DISC is also home to the data archive for the GPM predecessor, the Tropical Rainfall Measuring Mission (TRMM). Over the past 17 years, the GES DISC has served the scientific as well as other communities with TRMM data and user-friendly services. During the GPM era, the GES DISC will continue to provide user-friendly data services and customer support to users around the world. GPM products currently and to-be available: -Level-1 GPM Microwave Imager (GMI) and partner radiometer products, DPR products -Level-2 Goddard Profiling Algorithm (GPROF) GMI and partner products, DPR products -Level-3 daily and monthly products, DPR products -Integrated Multi-satellitE Retrievals for GPM (IMERG) products (early, late, and final) A dedicated Web portal (including user guides, etc.) has been developed for GPM data (http://disc.sci.gsfc.nasa.gov/gpm). Data services that are currently and to-be available include Google-like Mirador (http://mirador.gsfc.nasa.gov/) for data search and access; data access through various Web services (e.g., OPeNDAP, GDS, WMS, WCS); conversion into various formats (e.g., netCDF, HDF, KML (for Google Earth), ASCII); exploration, visualization, and statistical online analysis through Giovanni (http://giovanni.gsfc.nasa.gov); generation of value-added products; parameter and spatial subsetting; time aggregation; regridding; data version control and provenance; documentation; science support for proper data usage, FAQ, help desk; monitoring services (e.g. Current Conditions) for applications. The United User Interface (UUI) is the next step in the evolution of the GES DISC web site. It attempts to provide seamless access to data, information and services through a single interface without sending the user to different applications or URLs (e.g., search, access, subset, Giovanni, documents).

Reflections on bird and mammal risk assessment for plant protection products in the European Union: Past, present, and future.

PubMed

Brooks, Amy C; Fryer, Mike; Lawrence, Alan; Pascual, Juan; Sharp, Rachel

2017-03-01

The use of plant protection products on agricultural crops can result in exposure of birds and mammals to toxic chemicals. In the European Union, the risks from such exposures are assessed under the current (2009) guidance document from the European Food Safety Authority (EFSA), designed to increase the realism of the theoretical risk assessments in comparison to its predecessor (SANCO/4145/2000). Since its adoption over 7 yr ago, many plant protection products have been evaluated successfully using the 2009 EFSA guidance document. However, there are still significant areas of improvement recommended for future revisions of this guidance. The present Focus article discusses experiences to date with the current scheme, including levels of conservatism in input parameters and interpretation by regulatory authorities together with proposals for how the guidance document could be improved when it is revised in the not too distant future. Several areas for which further guidance is recommended have been identified, such as the derivation of ecologically relevant bird and mammal reproductive endpoints and the use of modeling approaches to contextualize risk assessments. Areas where existing databases could be improved were also highlighted, including the collation of relevant focal species across Europe and expansion of the residue database for food items. To produce a realistic and useable guidance document in the future, it is strongly recommended that there is open and constructive communication between industry, regulatory authorities, and the EFSA. Such collaboration would also encourage harmonization between member states, thus reducing workloads for both industry and regulatory authorities. Environ Toxicol Chem 2017;36:565-575. © 2017 SETAC. © 2017 SETAC.

Human electroencephalography and the tobacco industry: a review of internal documents.

PubMed

Panzano, Vincent C; Wayne, Geoffrey Ferris; Pickworth, Wallace B; Connolly, Gregory N

2010-04-01

To determine the extent and implications of internal human electroencephalography (EEG) research conducted by the tobacco industry. This study analysed internal documents that describe the results of human EEG studies conducted by tobacco manufacturers. Emphasis was placed on documents that pertain to the application of EEG to product evaluation efforts. Internal EEG research was used to determine dose-response relations and effective threshold levels for nicotine, emphasising the importance of form and mechanism of nicotine delivery for initiating robust central nervous system (CNS) effects. Internal studies also highlight the importance of human behaviour during naturalistic smoking, revealing neurophysiological markers of compensation during smoking of reduced nicotine cigarettes. Finally, internal research demonstrates the effectiveness of EEG for the evaluation of non-nicotine phenomena including smoke-component discrimination by smokers, classification of sensory characteristics and measurement of hedonics and other subjective effects. Tobacco manufacturers successfully developed objective, EEG-based techniques to evaluate the influence of product characteristics on acceptance and use. Internal results suggest that complex interactions between pharmacological, sensory and behavioural factors mediate the brain changes that occur with smoking. These findings have implications for current proposals regarding the regulation of tobacco products and argue for the incorporation of objective measures of product effects when evaluating the health risks of new and existing tobacco products.

Modern Corneal Eye-Banking Using a Software-Based IT Management Solution.

PubMed

Kern, C; Kortuem, K; Wertheimer, C; Nilmayer, O; Dirisamer, M; Priglinger, S; Mayer, W J

2018-01-01

Increasing government legislation and regulations in manufacturing have led to additional documentation regarding the pharmaceutical product requirements of corneal grafts in the European Union. The aim of this project was to develop a software within a hospital information system (HIS) to support the documentation process, to improve the management of the patient waiting list and to increase informational flow between the clinic and eye bank. After an analysis of the current documentation process, a new workflow and software were implemented in our electronic health record (EHR) system. The software takes over most of the documentation and reduces the time required for record keeping. It guarantees real-time tracing of all steps during human corneal tissue processing from the start of production until allocation during surgery and includes follow-up within the HIS. Moreover, listing of the patient for surgery as well as waiting list management takes place in the same system. The new software for corneal eye banking supports the whole process chain by taking over both most of the required documentation and the management of the transplant waiting list. It may provide a standardized IT-based solution for German eye banks working within the same HIS.

SIMBIOS Project

NASA Technical Reports Server (NTRS)

Fargion, Giulietta S.; McClain, Charles R.

2002-01-01

The purpose of this technical report is to provide current documentation of the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project activities, NASA Research Announcement (NRA) research status, satellite data processing, data product validation, and field calibration. This documentation is necessary to ensure that critical information is related to the scientific community and NASA management. This critical information includes the technical difficulties and challenges of validating and combining ocean color data from an array of independent satellite systems to form consistent and accurate global bio-optical time series products. This technical report is not meant as a substitute for scientific literature. Instead, it will provide a ready and responsive vehicle for the multitude of technical reports issued by an operational project. The SIMBIOS Science Team Principal Investigators' (PIs) original contributions to this report are in chapters four and above. The purpose of these contributions is to describe the current research status of the SIMBIOS-NRA-96 funded research. The contributions are published as submitted, with the exception of minor edits to correct obvious grammatical or clerical errors.

US EPA GLOBAL POSITIONING SYSTEMS - TECHNICAL IMPLEMENTATION GUIDANCE

EPA Science Inventory

The U.S. EPA Geospatial Quality Council (GQC) was formed in 1998 to provide Quality Assurance guidance for the development, use, and products of geospatial activities and research. The long-term goals of the GQC are expressed in a living document, currently the EPA Geospatial Qua...

Current Fault Management Trends in NASA's Planetary Spacecraft

NASA Technical Reports Server (NTRS)

Fesq, Lorraine M.

2009-01-01

The key product of this three-day workshop is a NASA White Paper that documents lessons learned from previous missions, recommended best practices, and future opportunities for investments in the fault management domain. This paper summarizes the findings and recommendations that are captured in the White Paper.

Does mere exposure change implicit associations between whole grain foods and taste?

USDA-ARS?s Scientific Manuscript database

The health benefits of whole grain (WG) consumption are well documented. Current Dietary Guidelines recommend that individuals consume = 3 servings per day. Despite increased variety, availability, and promotion of WG products, less than 5% of Americans consume the recommended amounts. Healthy adu...

Technical Committee on Aricultural Chemical Safety (ACSA) Life Stages Task Force

EPA Science Inventory

This document takes a life stages approach to the assessment of risk attributable to crop protection products, and well-known experts in the field are contributing authors. The paper presents an in-depth justification for proposed changes in current protocols for toxicity testing...

SIMBIOS Project 1999 Annual Report

NASA Technical Reports Server (NTRS)

McClain, Charles R.; Fargion, Giulietta S.

1999-01-01

The purpose of this technical memorandum is to provide current documentation of the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project activities, NASA Research Announcement (NRA) research status, satellite data processing, data product validation, and field calibration. This documentation is necessary to ensure that critical information is related to the scientific community and NASA management. This critical information includes the technical difficulties and challenges of combining ocean color data from an array of independent satellite systems to form consistent and accurate global bio-optical time series products. This technical report is not meant as a substitute for scientific literature. Instead, it will provide a ready and responsive vehicle for the multitude of technical reports issued by an operational project.

SIMBIOS Project 1998 Annual Report

NASA Technical Reports Server (NTRS)

McClain, Charles R.; Fargion, Giulietta, S.

1999-01-01

The purpose of this series of technical reports is to provide current documentation of the Sensor Intercomparison and Merger for Biological and Interdisciplinary Ocean Studies (SIMBIOS) Project activities, NASA Research Announcement (NRA) research status, satellite data processing, data product validation and field calibration. This documentation is necessary to ensure that critical information is related to the scientific community and NASA management. This critical information includes the technical difficulties and challenges of combining ocean color data from an array of independent satellite systems to form consistent and accurate global bio-optical time series products. This technical report is not meant to substitute for scientific literature. Instead, it will provide a ready and responsive vehicle for the multitude of technical reports issues by an operational project.

School Executive Website Study

ERIC Educational Resources Information Center

Thiede, Robert

2009-01-01

The School Executive Website will be a one-stop, online site for officials who are looking for educational data, best practices, product reviews, school documents, professional opinions, and/or job-related networking. The format of the website is designed in certain sections similar to other current and popular websites, such as Angie's List.com,…

Data Element Dictionary: Student. Second Edition.

ERIC Educational Resources Information Center

Martin, James S.

This document is intended to serve as a guide for institutions in the development of data bases to support the implementation of planning and management systems. This publication serves to identify and describe those student-related data elements: (1) required to support current National Center for Higher Education Systems (NCHEMS) products; (2)…

21 CFR 1271.230 - Process validation.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Process validation. 1271.230 Section 1271.230 Food..., AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.230 Process validation. (a... validation activities and results must be documented, including the date and signature of the individual(s...

21 CFR 1271.230 - Process validation.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Process validation. 1271.230 Section 1271.230 Food..., AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.230 Process validation. (a... validation activities and results must be documented, including the date and signature of the individual(s...

21 CFR 1271.230 - Process validation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Process validation. 1271.230 Section 1271.230 Food..., AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.230 Process validation. (a... validation activities and results must be documented, including the date and signature of the individual(s...

21 CFR 1271.230 - Process validation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Process validation. 1271.230 Section 1271.230 Food..., AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.230 Process validation. (a... validation activities and results must be documented, including the date and signature of the individual(s...

21 CFR 1271.230 - Process validation.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Process validation. 1271.230 Section 1271.230 Food..., AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.230 Process validation. (a... validation activities and results must be documented, including the date and signature of the individual(s...

Cosmopolitanism: Extending Our Theoretical Framework for Transcultural Technical Communication Research and Teaching

ERIC Educational Resources Information Center

Palmer, Zsuzsanna Bacsa

2013-01-01

The effects of globalization on communication products and processes have resulted in document features and interactional practices that are sometimes difficult to describe within current theoretical frameworks of inter/transcultural technical communication. Although it has been recognized in our field that the old theoretical frameworks and…

The Importance of Longitudinal Studies

NASA Astrophysics Data System (ADS)

Knezek, Patricia

2014-01-01

It has been eight years since the AAS Council unanimously endorsed the document, known as "Equity Now: The Pasadena Recommendations for Gender Equality in Astronomy," in January 2005. This document was the main product of the conference entitled “Women in Astronomy II: Ten Years After” (WIA II), held in June 2003 in Pasadena, CA. One of the key recommendations represented in that document was the need for a longitudinal study of astronomers. It was recognized that in order to understand our own field, how it is evolving, and the impact on individuals, we need to track people over time. I will discuss the fundamental questions that led to the recommendation, and set the stage for the current (ongoing) longitudinal study.

The Requirements Generation System: A tool for managing mission requirements

NASA Technical Reports Server (NTRS)

Sheppard, Sylvia B.

1994-01-01

Historically, NASA's cost for developing mission requirements has been a significant part of a mission's budget. Large amounts of time have been allocated in mission schedules for the development and review of requirements by the many groups who are associated with a mission. Additionally, tracing requirements from a current document to a parent document has been time-consuming and costly. The Requirements Generation System (RGS) is a computer-supported cooperative-work tool that assists mission developers in the online creation, review, editing, tracing, and approval of mission requirements as well as in the production of requirements documents. This paper describes the RGS and discusses some lessons learned during its development.

A tutorial on information retrieval: basic terms and concepts

PubMed Central

Zhou, Wei; Smalheiser, Neil R; Yu, Clement

2006-01-01

This informal tutorial is intended for investigators and students who would like to understand the workings of information retrieval systems, including the most frequently used search engines: PubMed and Google. Having a basic knowledge of the terms and concepts of information retrieval should improve the efficiency and productivity of searches. As well, this knowledge is needed in order to follow current research efforts in biomedical information retrieval and text mining that are developing new systems not only for finding documents on a given topic, but extracting and integrating knowledge across documents. PMID:16722601

Weather analysis and interpretation procedures developed for the US/Canada wheat and barley exploratory experiment

NASA Technical Reports Server (NTRS)

Trenchard, M. H. (Principal Investigator)

1980-01-01

Procedures and techniques for providing analyses of meteorological conditions at segments during the growing season were developed for the U.S./Canada Wheat and Barley Exploratory Experiment. The main product and analysis tool is the segment-level climagraph which depicts temporally meteorological variables for the current year compared with climatological normals. The variable values for the segment are estimates derived through objective analysis of values obtained at first-order station in the region. The procedures and products documented represent a baseline for future Foreign Commodity Production Forecasting experiments.

Electricity from biomass: A development strategy

NASA Astrophysics Data System (ADS)

1992-04-01

The purpose of this document is to review the current status of biomass power technology and to evaluate the future directions for development that could significantly enhance the contribution of biomass power to U.S. production of electricity. This document reviews the basic principles of biomass electric systems, the previous contributions of industry and the National Biomass Energy Programs to technology development, and the options for future technology development. It discusses the market for biomass electric technology and future needs for electric power production to help establish a market-oriented development strategy. It projects trends in the performance and cost of the technology and examines the changing dynamics of the power generation market place to evaluate specific opportunities for biomass power development. In a separate document, the Biomass Power Program Five Year R&D Plan, the details of schedules, funding, and roles of participating R&D organizations within the R&D program funded by the U.S. Department of Energy (DOE) are presented. In evaluating the future directions for research and development, two cases are examined.

Developing a Planetary Spatial Data Infrastructure for Evaluating Landing Sites and Performing Surface Operations for the Mars 2020 Lander

NASA Astrophysics Data System (ADS)

Fergason, R. L.; Laura, J.; Hare, T. M.; Otero, R.; Edgar, L. A.

2017-12-01

A Spatial Data Infrastructure (SDI) is a robust framework for data and data products, metadata, data access mechanisms, standards, policy, and a user community that helps to define and standardize the data necessary to meet some specified goal. The primary objective of an SDI is to improve communication, to enhance data access, and to aid in identifying gaps in knowledge. We are developing an SDI that describes the foundational data sets and accuracy requirements to evaluate landing site safety, facilitate the successful operation of Terrain Relative Navigation (TRN), and assist in the operation of the rover once it has successfully landed on Mars. Thru current development efforts, an implicit SDI exists for the Mars 2020 mission. An explicit SDI will allow us to identify any potential gaps in knowledge, facilitate communication between the different institutions involved in landing site evaluation and TRN development, and help ensure a smooth transition from landing to surface operations. This SDI is currently relevant to the Mars 2020 rover mission, but can also serve as a means to document current requirements for foundational data products and standards for future landed missions to Mars and other planetary bodies. To generate a Mars 2020-specific SDI, we must first document and rationalize data set and accuracy requirements for evaluating landing sites, performing surface operations, and inventorying Mars 2020 mission needs in terms of an SDI framework. This step will allow us to 1) evaluate and define what is needed for the acquisition of data and the generation and validation of data products, 2) articulate the accuracy and co-registration requirements, and 3) identify needs for data access (and eventual archiving). This SDI document will serve as a means to communicate the existing foundational products, standards that were followed in producing these products, and where and how these products can be accessed by the planetary community. This SDI will also facilitate discussions between the landing and surface operations groups to communicate the available data and identify unique needs to surface operations. Our goal is to continually review and update this SDI throughout the Mars 2020 landing site evaluation and operations, so that it remains relevant and effective as data availability and needs evolve.

Large Scale Document Inversion using a Multi-threaded Computing System

PubMed Central

Jung, Sungbo; Chang, Dar-Jen; Park, Juw Won

2018-01-01

Current microprocessor architecture is moving towards multi-core/multi-threaded systems. This trend has led to a surge of interest in using multi-threaded computing devices, such as the Graphics Processing Unit (GPU), for general purpose computing. We can utilize the GPU in computation as a massive parallel coprocessor because the GPU consists of multiple cores. The GPU is also an affordable, attractive, and user-programmable commodity. Nowadays a lot of information has been flooded into the digital domain around the world. Huge volume of data, such as digital libraries, social networking services, e-commerce product data, and reviews, etc., is produced or collected every moment with dramatic growth in size. Although the inverted index is a useful data structure that can be used for full text searches or document retrieval, a large number of documents will require a tremendous amount of time to create the index. The performance of document inversion can be improved by multi-thread or multi-core GPU. Our approach is to implement a linear-time, hash-based, single program multiple data (SPMD), document inversion algorithm on the NVIDIA GPU/CUDA programming platform utilizing the huge computational power of the GPU, to develop high performance solutions for document indexing. Our proposed parallel document inversion system shows 2-3 times faster performance than a sequential system on two different test datasets from PubMed abstract and e-commerce product reviews. CCS Concepts •Information systems➝Information retrieval • Computing methodologies➝Massively parallel and high-performance simulations. PMID:29861701

Large Scale Document Inversion using a Multi-threaded Computing System.

PubMed

Jung, Sungbo; Chang, Dar-Jen; Park, Juw Won

2017-06-01

Current microprocessor architecture is moving towards multi-core/multi-threaded systems. This trend has led to a surge of interest in using multi-threaded computing devices, such as the Graphics Processing Unit (GPU), for general purpose computing. We can utilize the GPU in computation as a massive parallel coprocessor because the GPU consists of multiple cores. The GPU is also an affordable, attractive, and user-programmable commodity. Nowadays a lot of information has been flooded into the digital domain around the world. Huge volume of data, such as digital libraries, social networking services, e-commerce product data, and reviews, etc., is produced or collected every moment with dramatic growth in size. Although the inverted index is a useful data structure that can be used for full text searches or document retrieval, a large number of documents will require a tremendous amount of time to create the index. The performance of document inversion can be improved by multi-thread or multi-core GPU. Our approach is to implement a linear-time, hash-based, single program multiple data (SPMD), document inversion algorithm on the NVIDIA GPU/CUDA programming platform utilizing the huge computational power of the GPU, to develop high performance solutions for document indexing. Our proposed parallel document inversion system shows 2-3 times faster performance than a sequential system on two different test datasets from PubMed abstract and e-commerce product reviews. •Information systems➝Information retrieval • Computing methodologies➝Massively parallel and high-performance simulations.

Natural language processing-based COTS software and related technologies survey.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stickland, Michael G.; Conrad, Gregory N.; Eaton, Shelley M.

Natural language processing-based knowledge management software, traditionally developed for security organizations, is now becoming commercially available. An informal survey was conducted to discover and examine current NLP and related technologies and potential applications for information retrieval, information extraction, summarization, categorization, terminology management, link analysis, and visualization for possible implementation at Sandia National Laboratories. This report documents our current understanding of the technologies, lists software vendors and their products, and identifies potential applications of these technologies.

Electrical utilities model for determining electrical distribution capacity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fritz, R. L.

1997-09-03

In its simplest form, this model was to obtain meaningful data on the current state of the Site`s electrical transmission and distribution assets, and turn this vast collection of data into useful information. The resulting product is an Electrical Utilities Model for Determining Electrical Distribution Capacity which provides: current state of the electrical transmission and distribution systems; critical Hanford Site needs based on outyear planning documents; decision factor model. This model will enable Electrical Utilities management to improve forecasting requirements for service levels, budget, schedule, scope, and staffing, and recommend the best path forward to satisfy customer demands at themore » minimum risk and least cost to the government. A dynamic document, the model will be updated annually to reflect changes in Hanford Site activities.« less

Potential Air Emission Impacts of Cellulosic Ethanol Production at Seven Demonstration Refineries in the United States

EPA Science Inventory

This paper reports on the estimated potential air emissions as found in air permits and supporting documentation for seven of the first group of pre-commercial or Ademonstration@ U.S. cellulosic ethanol refineries currently operating or planning to operate in the near future. Th...

Constructions of Social Inclusion within Australian Early Childhood Education and Care Policy Documents

ERIC Educational Resources Information Center

Wong, Sandie; Turner, Kay

2014-01-01

Social inclusion discourses have been powerful in informing early childhood policy contexts, both internationally and in Australia (the context of the current study) for the past decade or so. But little research has examined the productive aspects of social inclusion discourses particularly within early childhood education and care (ECEC) policy…

SIMBIOS Project; 2003 Annual Report

NASA Technical Reports Server (NTRS)

McClain, Charles R.; Fargion, Giulietta S.

2003-01-01

The purpose of this technical report is to provide current documentation of the the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project activities, NASA Research Announcement (NRA) research status, satellite data processing, data product validation, and field calibration. This documentation is necessary to ensure that critical information is related to the scientific community and NASA management. This critical information includes the technical difficulties and challenges of validating and combining ocean color data from an array of independent satellite systems to form consistent and accurate global bio-optical time series products. This technical report is not meant as a substitute for scientific literature. Instead, it will provide a ready and responsive vehicle for the multitude of technical reports issued by an operational project. The SIMBIOS Science Team Principal Investigators (PIs) original contributions to this report are in chapters four and above. The purpose of these contributions is to describe the current research status of the SIMBIOS-NRA-99 funded research. The contributions are published as submitted, with the exception of minor edits to correct obvious grammatical or clerical errors.

Current good manufacturing practice and investigational new drugs intended for use in clinical trials. Final rule.

PubMed

2008-07-15

The Food and Drug Administration (FDA) is amending the current good manufacturing practice (CGMP) regulations for human drugs, including biological products, to exempt most phase 1 investigational drugs from complying with the regulatory CGMP requirements. FDA will continue to exercise oversight of the manufacture of these drugs under FDA's general statutory CGMP authority and through review of the investigational new drug applications (IND). In addition, elsewhere in this issue of the Federal Register, FDA is announcing the availability of a guidance document entitled "Guidance for Industry: CGMP for Phase 1 Investigational Drugs" dated November 2007 (the companion guidance). This guidance document sets forth recommendations on approaches to compliance with statutory CGMP for the exempted phase 1 investigational drugs. FDA is taking this action to focus a manufacturer's effort on applying CGMP that is appropriate and meaningful for the manufacture of the earliest stage investigational drug products intended for use in phase 1 clinical trials while ensuring safety and quality. This action will also streamline and promote the drug development process.

Current Status of Legislation on Dietary Products for Sportspeople in a European Framework.

PubMed

Martínez-Sanz, José Miguel; Sospedra, Isabel; Baladía, Eduard; Arranz, Laura; Ortiz-Moncada, Rocío; Gil-Izquierdo, Angel

2017-11-08

The consumption of nutritional ergogenic aids is conditioned by laws/regulations, but standards/regulations vary between countries. The aim of this review is to explore legislative documents that regulate the use of nutritional ergogenic aids intended for sportspeople in a Spanish/European framework. A narrative review has been developed from official websites of Spanish (Spanish Agency of the Consumer, Food Safety, and Nutrition) and European (European Commission and European Food Safety Authority) bodies. A descriptive analysis of documents was performed. Eighteen legislative documents have been compiled in three sections: (1) Advertising of any type of food and/or product; (2) Composition, labeling, and advertising of foods; (3) Nutritional ergogenic aids. In spite of the existence of these legal documents, the regulation lacks guidance on the use/application of nutritional ergogenic aids for sportspeople. It is essential to prevent the introduction or dissemination of false, ambiguous, or inexact information and contents that induce an error in the receivers of the information. In this field, it is worth highlighting the roles of the European Food Safety Authority and the World Anti-Doping Agency, which provide information about consumer guidelines, prescribing practices, and recommendations for the prudent use of nutritional ergogenic aids.

Current Status of Legislation on Dietary Products for Sportspeople in a European Framework

PubMed Central

Arranz, Laura; Ortiz-Moncada, Rocío

2017-01-01

The consumption of nutritional ergogenic aids is conditioned by laws/regulations, but standards/regulations vary between countries. The aim of this review is to explore legislative documents that regulate the use of nutritional ergogenic aids intended for sportspeople in a Spanish/European framework. A narrative review has been developed from official websites of Spanish (Spanish Agency of the Consumer, Food Safety, and Nutrition) and European (European Commission and European Food Safety Authority) bodies. A descriptive analysis of documents was performed. Eighteen legislative documents have been compiled in three sections: (1) Advertising of any type of food and/or product; (2) Composition, labeling, and advertising of foods; (3) Nutritional ergogenic aids. In spite of the existence of these legal documents, the regulation lacks guidance on the use/application of nutritional ergogenic aids for sportspeople. It is essential to prevent the introduction or dissemination of false, ambiguous, or inexact information and contents that induce an error in the receivers of the information. In this field, it is worth highlighting the roles of the European Food Safety Authority and the World Anti-Doping Agency, which provide information about consumer guidelines, prescribing practices, and recommendations for the prudent use of nutritional ergogenic aids. PMID:29117104

Biosimilars: A consideration of the regulations in the United States and European union.

PubMed

Daller, Justin

2016-04-01

Biosimilars are defined as biological products that are highly similar to a reference product, notwithstanding minor differences in clinically inactive components. Biosimilars show no clinically meaningful differences in safety, purity, and potency of the product in comparison to the reference product. With the ever looming patent expiry of some major high cost biologics, biosimilar production is becoming ever more lucrative to companies. Europe (EU) set the precedent, followed by the United States (US) in early 2012, for the approval process for biosimilars. Therefore, the purpose of this paper is to explore the nature of the regulatory processes in the US and EU and to determine the requirements of each in the approval process of a biosimilar. The current Food and Drug Administration (FDA) and European Medicines Agency's (EMA) guidance documents for biosimilars were reviewed revealing a need for further clarifications, as well as specifically addressing Celltrion's and Sandoz's application for approval for the biosimilars infliximab and filgrastim, respectively. Currently, the FDA and EMA focus on comparability in terms of the clinical, pharmacokinetic (PK)/pharmacodynamic (PD), preclinical, biological activity, and physiochemical characterization results, as well as requiring a robust and consistent manufacturing process. Both the EU and US have prepared guidance documents for biosimilars that will result in biotherapeutics that are as safe and efficacious as the innovator product but the necessity exists to globally harmonize international nonproprietary naming nomenclature and clarify how the concept of pharmacovigilance, extrapolation, and interchangeability will be handled and regulated in the future. Copyright © 2015 Elsevier Inc. All rights reserved.

HISTORICAL AND CURRENT PERSPECTIVE IN THE USE OF THYROID EXTRACTS FOR THE TREATMENT OF HYPOTHYROIDISM.

PubMed

Hennessey, James V

2015-10-01

To describe the history, refinements, implementation, physiology, and clinical outcomes achieved over the past several centuries of thyroid hormone replacement strategies. A Medline search was initiated using the following search terms: bioidentical thyroid hormone, thyroid hormone extract, combination thyroxine (T4) and tri-iodothyronine (T3) therapy, homeopathic thyroid hormone therapy, and thyroid hormone replacement. Pertinent articles of interest were identified by title (and where available abstract) for further review. Additional references were identified during a review of the identified literature. A rich history of physician intervention in thyroid dysfunction was identified dating back more than 2 millennia. Although not precisely documented, thyroid ingestion from animal sources had been used for centuries but was finally scientifically described and documented in Europe over 130 years ago. Since the reports by Bettencourt and Murray, there has been a continuous documentation of outcomes, refinement of hormone preparation production, and updating of recommendations for the most effective and safe use of these hormones for relieving the symptoms of hypothyroidism. As the thyroid extract preparations contain both levothyroxine (LT4) and liothyronine (LT3), current guidelines do not endorse their use as controlled studies do not clearly document enhanced objective outcomes compared with LT4 monotherapy. Among current issues cited, the optimum ratio of LT4 to LT3 has yet to be determined, and the U.S. Food and Drug Administration (FDA) does not appear to be monitoring the thyroid hormone ratios or content in extract preparations on the market. Taken together, these limitations are important detriments to the use of thyroid extract products. The evolution of thyroid hormone therapies has been significant over the extended period of time they have been in use to treat hypothyroidism. Although numerous websites continue to advocate the use of thyroid hormone extracts as a superior therapy for hypothyroidism, none of the most recent guidelines of major endocrine societies recommend thyroid extract use for hypothyroidism.

Present status of the aflatoxin situation in the Philippines.

PubMed

Arim, R H

1995-01-01

Aflatoxin research in the Philippines started at the FNRI in 1967 with a survey on the aflatoxin content of various foods. Local researchers from government institutions and academe also conducted studies on the aflatoxin contamination of agricultural crops and their products/by-products. The data indicated that corn and peanuts are the two commodities that contain toxic levels of aflatoxin. Past and current research in the country is documented. Problems and research needs for the surveillance and/or control of aflatoxin contamination are discussed.

Social tagging in the life sciences: characterizing a new metadata resource for bioinformatics.

PubMed

Good, Benjamin M; Tennis, Joseph T; Wilkinson, Mark D

2009-09-25

Academic social tagging systems, such as Connotea and CiteULike, provide researchers with a means to organize personal collections of online references with keywords (tags) and to share these collections with others. One of the side-effects of the operation of these systems is the generation of large, publicly accessible metadata repositories describing the resources in the collections. In light of the well-known expansion of information in the life sciences and the need for metadata to enhance its value, these repositories present a potentially valuable new resource for application developers. Here we characterize the current contents of two scientifically relevant metadata repositories created through social tagging. This investigation helps to establish how such socially constructed metadata might be used as it stands currently and to suggest ways that new social tagging systems might be designed that would yield better aggregate products. We assessed the metadata that users of CiteULike and Connotea associated with citations in PubMed with the following metrics: coverage of the document space, density of metadata (tags) per document, rates of inter-annotator agreement, and rates of agreement with MeSH indexing. CiteULike and Connotea were very similar on all of the measurements. In comparison to PubMed, document coverage and per-document metadata density were much lower for the social tagging systems. Inter-annotator agreement within the social tagging systems and the agreement between the aggregated social tagging metadata and MeSH indexing was low though the latter could be increased through voting. The most promising uses of metadata from current academic social tagging repositories will be those that find ways to utilize the novel relationships between users, tags, and documents exposed through these systems. For more traditional kinds of indexing-based applications (such as keyword-based search) to benefit substantially from socially generated metadata in the life sciences, more documents need to be tagged and more tags are needed for each document. These issues may be addressed both by finding ways to attract more users to current systems and by creating new user interfaces that encourage more collectively useful individual tagging behaviour.

Reactor operation environmental information document

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haselow, J.S.; Price, V.; Stephenson, D.E.

1989-12-01

The Savannah River Site (SRS) produces nuclear materials, primarily plutonium and tritium, to meet the requirements of the Department of Defense. These products have been formed in nuclear reactors that were built during 1950--1955 at the SRS. K, L, and P reactors are three of five reactors that have been used in the past to produce the nuclear materials. All three of these reactors discontinued operation in 1988. Currently, intense efforts are being extended to prepare these three reactors for restart in a manner that protects human health and the environment. To document that restarting the reactors will have minimalmore » impacts to human health and the environment, a three-volume Reactor Operations Environmental Impact Document has been prepared. The document focuses on the impacts of restarting the K, L, and P reactors on both the SRS and surrounding areas. This volume discusses the geology, seismology, and subsurface hydrology. 195 refs., 101 figs., 16 tabs.« less

Social Sciences in Forestry, A Current Selected Bibliography, No. 57. Special Appendix: Theses and Dissertations in Progress.

ERIC Educational Resources Information Center

Schwab, Judith L., Ed.

1982-01-01

Documents which address the interface between forestry and the social sciences comprise this annotated bibliography. A subject-matter classification scheme is used to group publications by subheadings under five major heading: (1) social science applied to forestry at large; (2) applied to forestry's productive agents; (3) applied to forest…

78 FR 36693 - Rules and Regulations Under the Fur Products Labeling Act

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-19

... Rules currently do, a statement that the guarantor's printed name and address will meet the signature... to section 301.47: ``Note: The printed name and address on the invoice or other document will suffice... Band Employee Benefit Plan v. Smith Barney Shearson, Inc., 76 F.3d 1245 (1st Cir. 1996) (upholding...

77 FR 5717 - National Organic Program; Proposed Amendment to the National List of Allowed and Prohibited...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-06

... Service 7 CFR Part 205 [Document Number AMS-NOP-11-0063; NOP-11-11PR] RIN 0581-AD18 National Organic... address a recommendation submitted to the Secretary of Agriculture (Secretary) by the National Organic... maximum levels currently allowed in organic poultry production after October 1, 2012. This proposed rule...

Knowledge and Control in the Flexible Workplace. EAE610 The Changing Workplace: Part B.

ERIC Educational Resources Information Center

Watkins, Peter

This publication is part of the study materials for the distance education course, The Changing Workplace: Part B, in the Open Campus Program at Deakin University. The first part of the document examines current thinking regarding knowledge and control in workplaces emphasizing flexible production systems, flexible technology, and a flexible work…

Advanced lighting guidelines: 1993. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eley, C.; Tolen, T.M.; Benya, J.R.

1993-12-31

The 1993 Advanced Lighting Guidelines document consists of twelve guidelines that provide an overview of specific lighting technologies and design application techniques utilizing energy-efficient lighting practice. Lighting Design Practice assesses energy-efficient lighting strategies, discusses lighting issues, and explains how to obtain quality lighting design and consulting services. Luminaires and Lighting Systems surveys luminaire equipment designed to take advantage of advanced technology lamp products and includes performance tables that allow for accurate estimation of luminaire light output and power input. The additional ten guidelines -- Computer-Aided Lighting Design, Energy-Efficient Fluorescent Ballasts, Full-Size Fluorescent Lamps, Compact Fluorescent Lamps, Tungsten-Halogen Lamps, Metal Halidemore » and HPS Lamps, Daylighting and Lumen Maintenance, Occupant Sensors, Time Scheduling Systems, and Retrofit Control Technologies -- each provide a product technology overview, discuss current products on the lighting equipment market, and provide application techniques. This document is intended for use by electric utility personnel involved in lighting programs, lighting designers, electrical engineers, architects, lighting manufacturers` representatives, and other lighting professionals.« less

Emission of biocides from hospitals: comparing current survey results with European Union default values.

PubMed

Tluczkiewicz, Inga; Bitsch, Annette; Hahn, Stefan; Hahn, Torsten

2010-04-01

Under the European Union (EU) Biocidal Products Directive 98/8/EC, comprehensive evaluations on substances of the Third Priority List were conducted until 31 July 2007. This list includes, among other categories, disinfectants for human hygiene (e.g., skin and surface disinfection). For environmental exposure assessment of biocides, the EU emission scenarios apply. Currently available default values for disinfectants are based on consumption data from not more than 8 hospitals and were originally assembled for other purposes. To revalidate these default values, a survey on annual consumption data was performed in 27 German hospitals. These data were analyzed to provide consumption data per bed and day and per nurse and day for particular categories of active ingredients and were compared with default values from the EU emission scenario documents. Although several deviations were detected, an overall acceptable correspondence between Emission Scenario Documents default values and the current survey data was found. (c) 2009 SETAC

Soil Moisture Active Passive (SMAP) Mission Level 4 Surface and Root Zone Soil Moisture (L4_SM) Product Specification Document

NASA Technical Reports Server (NTRS)

Reichle, Rolf H.; Ardizzone, Joseph V.; Kim, Gi-Kong; Lucchesi, Robert A.; Smith, Edmond B.; Weiss, Barry H.

2015-01-01

This is the Product Specification Document (PSD) for Level 4 Surface and Root Zone Soil Moisture (L4_SM) data for the Science Data System (SDS) of the Soil Moisture Active Passive (SMAP) project. The L4_SM data product provides estimates of land surface conditions based on the assimilation of SMAP observations into a customized version of the NASA Goddard Earth Observing System, Version 5 (GEOS-5) land data assimilation system (LDAS). This document applies to any standard L4_SM data product generated by the SMAP Project. The Soil Moisture Active Passive (SMAP) mission will enhance the accuracy and the resolution of space-based measurements of terrestrial soil moisture and freeze-thaw state. SMAP data products will have a noteworthy impact on multiple relevant and current Earth Science endeavors. These include: Understanding of the processes that link the terrestrial water, the energy and the carbon cycles, Estimations of global water and energy fluxes over the land surfaces, Quantification of the net carbon flux in boreal landscapes Forecast skill of both weather and climate, Predictions and monitoring of natural disasters including floods, landslides and droughts, and Predictions of agricultural productivity. To provide these data, the SMAP mission will deploy a satellite observatory in a near polar, sun synchronous orbit. The observatory will house an L-band radiometer that operates at 1.40 GHz and an L-band radar that operates at 1.26 GHz. The instruments will share a rotating reflector antenna with a 6 meter aperture that scans over a 1000 km swath.

Evaluation of a program supporting scholarly productivity for new investigators.

PubMed

Mavis, Brian; Katz, Michael

2003-07-01

Like many groups, the March of Dimes Birth Defects Foundation has a long-term interest in funding new investigators. This study documents the career outcomes related to scientific productivity, research support, and current faculty positions of new investigators funded by the Foundation. All successful applicants from 1983 to 1987 (n = 244) were compared with unsuccessful applicants from 1986 and 1987 (n = 195). Outcomes over a ten-year period were examined. Online databases were used to measure quantity and quality of scholarship, as well as federal grant awards. Institutional prestige was based on the 1982 and 1995 reports from the Conference Board of Associated Research Councils. A follow-up survey of successful applicants identified current employment and research activities. Successful and unsuccessful applicants did not differ significantly except that women were underrepresented among successful applicants. Applicants receiving funding were more productive in terms of the quantity and quality of publications as well as federal grant support. A greater proportion of successful applicants came from top-ranked institutions and at follow-up the proportion of successful applicants in top-ranked programs increased. At follow-up, most successful applicants had tenure-track appointments with significant time dedicated to research. The findings document the Foundation's investment in new investigators to promote scholarly productivity and career development and validate the criteria and process used to select successful applicants. The award provides new investigators with control over resources to facilitate their research programs and enhances the confidence and recognition of recipients.

242A Distributed Control System Year 2000 Acceptance Test Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

TEATS, M.C.

1999-08-31

This report documents acceptance test results for the 242-A Evaporator distributive control system upgrade to D/3 version 9.0-2 for year 2000 compliance. This report documents the test results obtained by acceptance testing as directed by procedure HNF-2695. This verification procedure will document the initial testing and evaluation of the potential 242-A Distributed Control System (DCS) operating difficulties across the year 2000 boundary and the calendar adjustments needed for the leap year. Baseline system performance data will be recorded using current, as-is operating system software. Data will also be collected for operating system software that has been modified to correct yearmore » 2000 problems. This verification procedure is intended to be generic such that it may be performed on any D/3{trademark} (GSE Process Solutions, Inc.) distributed control system that runs with the VMSTM (Digital Equipment Corporation) operating system. This test may be run on simulation or production systems depending upon facility status. On production systems, DCS outages will occur nine times throughout performance of the test. These outages are expected to last about 10 minutes each.« less

Parameters for determining inoculated pack/challenge study protocols.

PubMed

2010-01-01

The National Advisory Committee on Microbiological Criteria for Foods developed guidelines for conducting challenge studies on pathogen inhibition and inactivation studies in a variety of foods. The document is intended for use by the food industry, including food processors, food service operators, and food retailers; federal, state, and local food safety regulators; public health officials; food testing laboratories; and process authorities. The document is focused on and limited to bacterial inactivation and growth inhibition and does not make specific recommendations with respect to public health. The Committee concluded that challenge studies should be designed considering the most current advances in methodologies, current thinking on pathogens of concern, and an understanding of the product preparation, variability, and storage conditions. Studies should be completed and evaluated under the guidance of an expert microbiologist in a qualified laboratory and should include appropriate statistical design and data analyses. This document provides guidelines for choice of microorganisms for studies, inoculum preparation, inoculum level, methods of inoculation, incubation temperatures and times, sampling considerations, and interpreting test results. Examples of appropriately designed growth inhibition and inactivation studies are provided.

Data Stewardship and Long-Term Archive of ICESat Data at the National Snow and Ice Data Center (NSIDC)

NASA Astrophysics Data System (ADS)

Fowler, D. K.; Moses, J. F.; Duerr, R. E.; Webster, D.; Korn, D.

2010-12-01

Data Stewardship is becoming a principal part of a data manager’s work at NSIDC. It is vitally important that our organization makes a commitment to both current and long-term goals of data management and the preservation of our scientific data. Data must be available to researchers not only during active missions, but long after missions end. This includes maintaining accurate documentation, data tools, and a knowledgeable user support staff. NSIDC is preparing for long-term support of the ICESat mission data. Though ICESat has seen its last operational day, the data is still being improved and NSIDC is scheduled to archive the final release, Release 33, starting late in 2010. This release will include the final adjustments to the processing algorithms and will produce the best possible products to date. Along with the higher-level data sets, all supporting documentation will be archived at NSIDC. For the long-term archive, it is imperative that there is sufficient information about how products were prepared in order to convince future researchers that the scientific results are reproducible. The processing algorithms along with the Level 0 and ancillary products used to create the higher-level products will be archived and made available to users. This can enable users to examine production history, to derive revised products and to create their own products. Also contained in the long-term archive will be pre-launch, calibration/validation, and test data. These data are an important part of the provenance which must be preserved. For longevity, we’ll need to archive the data and documentation in formats that will be supported in the years to come.

Worldwide research productivity on tramadol: a bibliometric analysis.

PubMed

Sweileh, Waleed M; Shraim, Naser Y; Zyoud, Sa'ed H; Al-Jabi, Samah W

2016-01-01

Pain management and safe use of analgesics is an important medical issue. Tramadol is an old analgesic with controversial properties. Evaluation of worldwide scientific output on tramadol has not been explored. Therefore, the main objective of this study was to give a bibliometric overview of global research productivity on tramadol. SciVerse Scopus was used to retrieve and quantitatively and qualitatively analyze worldwide publications on tramadol. A total of 2059 original and review research articles on tramadol were retrieved from Scopus. Forty-six documents (2.23 %) were published in Anesthesia and Analgesia Journal whereas 30 (1.46 %) were published in Arzneimittel Forschung Drug Research Journal. Retrieved tramadol documents were published from 71 countries and appeared in 160 peer reviewed journals. Although the United States of America (259; 12.86 %) had the largest contribution to tramadol publications; the contribution by other countries like Turkey (232; 11.27) India (189; 8.09 %) and Germany (176; 8.56 % was not far away from that of USA. The most productive institution was Grunenthal, Germany (47; 2.28 %) followed by Tehran University of Medical Sciences, Iran (29; 1.41 %), and, Ortho-McNeil Pharmaceutical Incorporated, USA (25; 1.21 %). Of the 2059 documents, there were 370 documents about dependence. The leading institution in documents pertaining to tramadol dependence was Grunenthal GmbH (18; 4.86 %) followed by Ortho-McNeil Pharmaceutical Incorporated (17; 4.59 %). The current study showed that there is an obvious interest in tramadol research. More efforts are needed to clarify the abuse potential and safety profile of tramadol to help in determining the legal status of tramadol. Collaboration among pharmaceutical industry, clinical researchers and academic institutions can improve research quantity and quality on tramadol.

19 CFR 113.45 - Charge for production of a missing document made against a continuous bond.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Charge for production of a missing document made... Charge for production of a missing document made against a continuous bond. When a continuous bond secures the production of a missing document and the bond is breached by the principal's failure to timely...

19 CFR 113.45 - Charge for production of a missing document made against a continuous bond.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Charge for production of a missing document made... Charge for production of a missing document made against a continuous bond. When a continuous bond secures the production of a missing document and the bond is breached by the principal's failure to timely...

19 CFR 113.45 - Charge for production of a missing document made against a continuous bond.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Charge for production of a missing document made... Charge for production of a missing document made against a continuous bond. When a continuous bond secures the production of a missing document and the bond is breached by the principal's failure to timely...

19 CFR 113.45 - Charge for production of a missing document made against a continuous bond.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Charge for production of a missing document made... Charge for production of a missing document made against a continuous bond. When a continuous bond secures the production of a missing document and the bond is breached by the principal's failure to timely...

19 CFR 113.45 - Charge for production of a missing document made against a continuous bond.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Charge for production of a missing document made... Charge for production of a missing document made against a continuous bond. When a continuous bond secures the production of a missing document and the bond is breached by the principal's failure to timely...

Decal Process Document and Catalog

NASA Technical Reports Server (NTRS)

1999-01-01

The Decal Process Document and Catalog, JSC 27260 is the standard flight decal catalog, complete with illustrations and part numbers. As hardware developers identify labels that have common applicability across end items, these labels can be evaluated for "standard decal classification" and entered into the decal catalog for general use. The hardware developer must have a label design that meets current, applicable labeling requirements, and submit to the Decal Design and Production Facility (DDPF) as a standard label candidate. Upon approval, the label will be added to the decal catalog. The Decal Process Document and Catalog provides a selection of decals from which the NASA and NASA contractor customers can easily order. The decals shown in the catalog have been previously produced and have released engineering/fabrication drawings on file in the (DDPF). A released drawing is required before a decal can be produced or placed into the catalog. Some decals included in the catalog have a common applicability and are used in various NASA vehicles/habitats. It is the intent of the DDPF to maintain this catalog as a "living document" to which decals/placards can be added as they are repeatedly used. The advantage of identifYing flight decals in this catalog is that a released drawing is already in place, and the products will be flight certified.

Phonological Priming with Nonwords in Children with and without Specific Language Impairment

ERIC Educational Resources Information Center

Brooks, Patricia J.; Seiger-Gardner, Liat; Obeid, Rita; MacWhinney, Brian

2015-01-01

Purpose: The cross-modal picture-word interference task is used to examine contextual effects on spoken-word production. Previous work has documented lexical-phonological interference in children with specific language impairment (SLI) when a related distractor (e.g., bell) occurs prior to a picture to be named (e.g., a bed). In the current study,…

A Multi-Dimensional Approach to Gradient Change in Phonological Acquisition: A Case Study of Disordered Speech Development

ERIC Educational Resources Information Center

Glaspey, Amy M.; MacLeod, Andrea A. N.

2010-01-01

The purpose of the current study is to document phonological change from a multidimensional perspective for a 3-year-old boy with phonological disorder by comparing three measures: (1) accuracy of consonant productions, (2) dynamic assessment, and (3) acoustic analysis. The methods included collecting a sample of the targets /s, [image omitted],…

Professional Development Capacity Building in Pennsylvania's Regional Staff Development Program: The "WorkNet" Project. Final Report [and] WorkNet Workplace Literacy Trainer's Guide.

ERIC Educational Resources Information Center

Carman, Priscilla S.

These two documents are products of a project to improve the capability of the Pennsylvania Regional Staff Development Centers to provide current, research-based workplace literacy training and technical assistance to adult basic and literacy education programs. The final report describes these project activities: development of training materials…

Measuring Academic Productivity and Changing Definitions of Scientific Impact

PubMed Central

Sarli, Cathy C.; Carpenter, Christopher R.

2016-01-01

This manuscript provides a brief overview of the history of communication of scientific research and reporting of scientific research impact outcomes. Current day practices are outlined along with examples of how organizations and libraries are providing tools to evaluate and document the impact of scientific research to provide a meaningful narrative suitable for a variety of purposes and audiences. PMID:25438359

Arab oil and gas directory 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1985-01-01

The directory provides detailed statistics and information on aspects of oil and gas production, exploration and developments in the 24 Arab countries of the Middle East and North Africa and in Iran. It includes the texts of relevant new laws and official documents, official surveys, current projects and developments, up-to-date statistics covering OPEC and OAPEC member countries, and has 26 maps.

47 CFR 0.422 - Current action documents and public notices.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Current action documents and public notices. 0.422 Section 0.422 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION General Information Forms and Documents Available Upon Request § 0.422 Current action documents and public...

Critical review on the Environmental Risk Assessment of medicinal products for human use in the centralised procedure.

PubMed

Caneva, Laura; Bonelli, Milton; Papaluca-Amati, Marisa; Vidal, Jean-Marc

2014-04-01

In this article we analyse the Environmental Risk Assessment (ERA) of 59 medicinal products for human use authorised in the EU through the centralised procedure between 2011 and 2012, to establish whether company submissions are compliant with the European Medicines Agency (EMA) guideline and complete in terms of data and study reports provided. The most frequent questions raised by EU regulatory authorities are described, together with an evaluation of the presence and quality of ERA-related information in published regulatory assessment documents. The results of this review show recent improvement in ERA-related data presented in regulatory assessment documents available to the public while also highlighting a need to develop further guidance on environmental issues in order to assist applicants improve their ERA dossiers and overcome current shortcomings. Copyright © 2014 Elsevier Inc. All rights reserved.

MODIS Validation, Data Merger and Other Activities Accomplished by the SIMBIOS Project: 2002-2003

NASA Technical Reports Server (NTRS)

Fargion, Giulietta S.; McClain, Charles R.

2003-01-01

The purpose of this technical report is to provide current documentation of the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project activities, satellite data processing, and data product validation. This documentation is necessary to ensure that critical information is related to the scientific community and NASA management. This critical information includes the technical difficulties and challenges of validating and combining ocean color data from an array of independent satellite systems to form consistent and accurate global bio-optical time series products. This technical report focuses on the SIMBIOS Project s efforts in support of the Moderate-Resolution Imaging Spectroradiometer (MODIS) on the Earth Observing System (EOS) Terra platform (similar evaluations of MODIS/Aqua are underway). This technical report is not meant as a substitute for scientific literature. Instead, it will provide a ready and responsive vehicle for the multitude of technical reports issued by an operational project.

Computer aided design and manufacturing: analysis and development of research issues

NASA Astrophysics Data System (ADS)

Taylor, K.; Jadeja, J. C.

2005-11-01

The paper focuses on the current issues in the areas of computer aided manufacturing and design. The importance of integrating CAD and CAM is analyzed. The associated issues with the integration and recent advancements in this field have been documented. The development of methods for enhancing productivity is explored. A research experiment was conducted in the laboratories of West Virginia University with an objective to portray effects of various machining parameters on production. Graphical results and their interpretations are supplied to better realize the main purpose of the experimentation.

Synthesis: Intertwining product and process

NASA Technical Reports Server (NTRS)

Weiss, David M.

1990-01-01

Synthesis is a proposed systematic process for rapidly creating different members of a program family. Family members are described by variations in their requirements. Requirements variations are mapped to variations on a standard design to generate production quality code and documentation. The approach is made feasible by using principles underlying design for change. Synthesis incorporates ideas from rapid prototyping, application generators, and domain analysis. The goals of Synthesis and the Synthesis process are discussed. The technology needed and the feasibility of the approach are also briefly discussed. The status of current efforts to implement Synthesis methodologies is presented.

Automated Generation of Technical Documentation and Provenance for Reproducible Research

NASA Astrophysics Data System (ADS)

Jolly, B.; Medyckyj-Scott, D.; Spiekermann, R.; Ausseil, A. G.

2017-12-01

Data provenance and detailed technical documentation are essential components of high-quality reproducible research, however are often only partially addressed during a research project. Recording and maintaining this information during the course of a project can be a difficult task to get right as it is a time consuming and often boring process for the researchers involved. As a result, provenance records and technical documentation provided alongside research results can be incomplete or may not be completely consistent with the actual processes followed. While providing access to the data and code used by the original researchers goes some way toward enabling reproducibility, this does not count as, or replace, data provenance. Additionally, this can be a poor substitute for good technical documentation and is often more difficult for a third-party to understand - particularly if they do not understand the programming language(s) used. We present and discuss a tool built from the ground up for the production of well-documented and reproducible spatial datasets that are created by applying a series of classification rules to a number of input layers. The internal model of the classification rules required by the tool to process the input data is exploited to also produce technical documentation and provenance records with minimal additional user input. Available provenance records that accompany input datasets are incorporated into those that describe the current process. As a result, each time a new iteration of the analysis is performed the documentation and provenance records are re-generated to provide an accurate description of the exact process followed. The generic nature of this tool, and the lessons learned during its creation, have wider application to other fields where the production of derivative datasets must be done in an open, defensible, and reproducible way.

The Earth System Documentation (ES-DOC) project

NASA Astrophysics Data System (ADS)

Murphy, S.; Greenslade, M. A.; Treshansky, A.; DeLuca, C.; Guilyardi, E.; Denvil, S.

2013-12-01

Earth System Documentation (ES-DOC) is an international project supplying high quality tools and services in support of Earth system documentation creation, analysis and dissemination. It is nurturing a sustainable standards based documentation ecosystem that aims to become an integral part of the next generation of exa-scale dataset archives. ES-DOC leverages open source software, and applies a software development methodology that places end-user narratives at the heart of all it does. ES-DOC has initially focused upon nurturing the Earth System Model (ESM) documentation eco-system. Within this context ES-DOC leverages the emerging Common Information Model (CIM) metadata standard, which has supported the following projects: ** Coupled Model Inter-comparison Project Phase 5 (CMIP5); ** Dynamical Core Model Inter-comparison Project (DCMIP-2012); ** National Climate Predictions and Projections Platforms (NCPP) Quantitative Evaluation of Downscaling Workshop (QED-2013). This presentation will introduce the project to a wider audience and will demonstrate the current production level capabilities of the eco-system: ** An ESM documentation Viewer embeddable into any website; ** An ESM Questionnaire configurable on a project by project basis; ** An ESM comparison tool reusable across projects; ** An ESM visualization tool reusable across projects; ** A search engine for speedily accessing published documentation; ** Libraries for streamlining document creation, validation and publishing pipelines.

Chyawanprash: A review of therapeutic benefits as in authoritative texts and documented clinical literature.

PubMed

Narayana, D B Anantha; Durg, Sharanbasappa; Manohar, P Ram; Mahapatra, Anita; Aramya, A R

2017-02-02

Chyawanprash (CP), a traditional immune booster recipe, has a long history of ethnic origin, development, household preparation and usage. There are even mythological stories about the origin of this recipe including its nomenclature. In the last six decades, CP, because of entrepreneurial actions of some research Vaidyas (traditional doctors) has grown to industrial production and marketing in packed forms to a large number of consumers/patients like any food or health care product. Currently, CP has acquired a large accepted user base in India and in a few countries out-side India. Authoritative texts, recognized by the Drugs and Cosmetics Act of India, describe CP as an immunity enhancer and strength giver meant for improving lung functions in diseases with compromised immunity. This review focuses on published clinical efficacy and safety studies of CP for correlation with health benefits as documented in the authoritative texts, and also briefs on its recipes and processes. Authoritative texts were searched for recipes, processes, and other technical details of CP. Labels of marketing CP products (Indian) were studied for the health claims. Electronic search for studies of CP on efficacy and safety data were performed in PubMed/MEDLINE and DHARA (Digital Helpline for Ayurveda Research Articles), and Ayurvedic books were also searched for clinical studies. The documented clinical studies from electronic databases and Ayurvedic books evidenced that individuals who consume CP regularly for a definite period of time showed improvement in overall health status and immunity. However, most of the clinical studies in this review are of smaller sample size and short duration. Further, limitation to access and review significant data on traditional products like CP in electronic databases was noted. Randomized controlled trials of high quality with larger sample size and longer follow-up are needed to have significant evidence on the clinical use of CP as immunity booster. Additional studies involving measurement of current biomarkers of immunity pre- and post-consumption of the product as well as benefits accruing with the use of CP as an adjuvant are suggested. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

TANK VAPOR CHEMICALS OF POTENTIAL CONCERN & EXISTING DIRECT READING INSTRUMENTION & PERSONAL PROTECTIVE EQUIPMENT CONSIDERATIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

BUTLER, N.K.

2004-11-01

This document takes the newly released Industrial Hygiene Chemical Vapor Technical Basis (RPP-22491) and evaluates the chemicals of potential concern (COPC) identified for selected implementation actions by the industrial hygiene organization. This document is not intended as a hazard analysis with recommended controls for all tank farm activities. Not all of the chemicals listed are present in all tanks; therefore, hazard analyses can and should be tailored as appropriate. Detection of each chemical by current industrial hygiene non-specific instrumentation in use at the tank farms is evaluated. Information gaps are identified and recommendations are made to resolve these needs. Ofmore » the 52 COPC, 34 can be detected with existing instrumentation. Three additional chemicals could be detected with a photoionization detector (PID) equipped with a different lamp. Discussion with specific instrument manufacturers is warranted. Consideration should be given to having the SapphIRe XL customized for tank farm applications. Other instruments, sampling or modeling techniques should be evaluated to estimate concentrations of chemicals not detected by direct reading instruments. In addition, relative instrument response needs to be factored in to action levels used for direct reading instruments. These action levels should be correlated to exposures to the COPC and corresponding occupational exposure limits (OELs). The minimum respiratory protection for each of the COPC is evaluated against current options. Recommendations are made for respiratory protection based on each chemical. Until exposures are sufficiently quantified and analyzed, the current use of supplied air respiratory protection is appropriate and protective for the COPC. Use of supplied air respiratory protection should be evaluated once a detailed exposure assessment for the COPC is completed. The established tank farm OELs should be documented in the TFC-PLN-34. For chemicals without an established tank farm OEL, consideration should be given to adopting protective limits from NIOSH, AIHA, or developing OELs. Protective gloves and suits are evaluated for each chemical for which information is available. Information gaps are identified for some of the compounds and materials. Recommendations are made for resolving these needs. Based on available information, Silver Shield{reg_sign} gloves are promising for tank farm applications. However, permeation testing documentation is needed for the COPC and mixtures for Silver Shield{reg_sign} gloves to evaluate their protectiveness. North Safety Products is expected to provide the requested documentation. Multiple Tychem{reg_sign} products are available. There is overlap between chemicals and effective materials. Further hazard evaluation to determine actual hazards and permeation testing documentation is required to assess the efficacy of a single Tychem{reg_sign} product for tank farm applications. All of this chemical specific data is combined into a spreadsheet that will assist the industrial hygienist in the selection of monitoring instruments, respiratory protection selection and protective clothing for performing work at a specific tank(s).« less

Towards a Standard for Provenance and Context for Preservation of Data for Earth System Science

NASA Technical Reports Server (NTRS)

Ramaprian, Hampapuram K.; Moses, John F.

2011-01-01

Long-term data sets with data from many missions are needed to study trends and validate model results that are typical in Earth System Science research. Data and derived products originate from multiple missions (spaceborne, airborne and/or in situ) and from multiple organizations. During the missions as well as well past their termination, it is essential to preserve the data and products to support future studies. Key aspects of preservation are: preserving bits and ensuring data are uncorrupted, preserving understandability with appropriate documentation, and preserving reproducibility of science with appropriate documentation and other artifacts. Computer technology provides adequate standards to ensure that, with proper engineering, bits are preserved as hardware evolves. However, to ensure understandability and reproducibility, it is essential to plan ahead to preserve all the relevant data and information. There are currently no standards to identify the content that needs to be preserved, leading to non-uniformity in content and users not being sure of whether preserved content is comprehensive. Each project, program or agency can specify the items to be preserved as a part of its data management requirements. However, broader community consensus that cuts across organizational or national boundaries would be needed to ensure comprehensiveness, uniformity and long-term utility of archived data. The Federation of Earth Science Information Partners (ESIP), a diverse network of scientists, data stewards and technology developers, has a forum for ESIP members to collaborate on data preservation issues. During early 2011, members discussed the importance of developing a Provenance and Context Content Standard (PCCS) and developed an initial list of content items. This list is based on the outcome of a NASA and NOAA meeting held in 1998 under the auspices of the USGCRP, documentation requirements from NOAA and our experience with some of the NASA Earth science missions. The items are categorized into the following 8 high level categories: Preflight/Pre-Operations, Products (Data), Product Documentation, Mission Calibration, Product Software, Algorithm Input, Validation, Software Tools.

45 CFR 1201.5 - Testimony and production of documents prohibited unless approved by appropriate Corporation...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Testimony and production of documents prohibited... Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE PRODUCTION OR... and production of documents prohibited unless approved by appropriate Corporation officials. (a...

22 CFR 172.4 - Testimony and production of documents prohibited unless approved by appropriate Department...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Testimony and production of documents... DEPARTMENT OF STATE ACCESS TO INFORMATION SERVICE OF PROCESS; PRODUCTION OR DISCLOSURE OF OFFICIAL... § 172.4 Testimony and production of documents prohibited unless approved by appropriate Department...

Purdue University National Biomedical Tracer Facility: Project definition phase. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, M.A.

The proposed National Biomedical Tracer Facility (NBTF) will house a high-current accelerator dedicated to production of short-lived radionuclides for biomedical and scientific research. The NBTF will play a vital role in repairing and maintaining the United States` research infrastructure for generation of essential accelerator-based radioisotopes. If properly designed and managed, the NBTF should also achieve international recognition as a Center-of-Excellence for research on radioisotope production methods and for associated education and training. The current report documents the results of a DOE-funded NBTF Project Definition Phase study carried out to better define the technical feasibility and projected costs of establishing andmore » operating the NBTF. This report provides an overview of recommended Facility Design and Specifications, including Accelerator Design, Building Design, and the associated Construction Cost Estimates and Schedule. It is recommended that the NBTF be established as an integrated, comprehensive facility for meeting the diverse production, research, and educational missions set forth in previous documents. Based on an analysis of the projected production demands that will be placed on the NBTF, it appears that a 70 MeV, 1 mA, negative ion cyclotron will offer a good balance between production capabilities and the costs of accelerator purchase and operation. A preliminary architectural plan is presented for a facility designed specifically to fulfill the functions of the NBTF in a cost-effective manner. This report also presents a detailed analysis of the Required Federal State, and Local Permits that may be needed to establish the NBTF, along with schedules and cost estimates for obtaining these permits. The Handling, Storage, and Disposal of Radioactive Waste will pose some significant challenges in the operation of the NBTF, but at this stage of planning the associated problems do not appear to be prohibitive.« less

36 CFR 703.16 - Policy on presentation of testimony and production of documents.

Code of Federal Regulations, 2014 CFR

2014-07-01

... testimony and production of documents. 703.16 Section 703.16 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.16 Policy on presentation of testimony and production of documents. No Library of Congress employee may provide testimony or produce...

36 CFR 703.16 - Policy on presentation of testimony and production of documents.

Code of Federal Regulations, 2012 CFR

2012-07-01

... testimony and production of documents. 703.16 Section 703.16 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.16 Policy on presentation of testimony and production of documents. No Library of Congress employee may provide testimony or produce...

36 CFR 703.16 - Policy on presentation of testimony and production of documents.

Code of Federal Regulations, 2011 CFR

2011-07-01

... testimony and production of documents. 703.16 Section 703.16 Parks, Forests, and Public Property LIBRARY OF... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.16 Policy on presentation of testimony and production of documents. No Library of Congress employee may provide testimony or produce...

Detection and traceability of genetically modified organisms in the food production chain.

PubMed

Miraglia, M; Berdal, K G; Brera, C; Corbisier, P; Holst-Jensen, A; Kok, E J; Marvin, H J P; Schimmel, H; Rentsch, J; van Rie, J P P F; Zagon, J

2004-07-01

Both labelling and traceability of genetically modified organisms are current issues that are considered in trade and regulation. Currently, labelling of genetically modified foods containing detectable transgenic material is required by EU legislation. A proposed package of legislation would extend this labelling to foods without any traces of transgenics. These new legislations would also impose labelling and a traceability system based on documentation throughout the food and feed manufacture system. The regulatory issues of risk analysis and labelling are currently harmonised by Codex Alimentarius. The implementation and maintenance of the regulations necessitates sampling protocols and analytical methodologies that allow for accurate determination of the content of genetically modified organisms within a food and feed sample. Current methodologies for the analysis of genetically modified organisms are focused on either one of two targets, the transgenic DNA inserted- or the novel protein(s) expressed- in a genetically modified product. For most DNA-based detection methods, the polymerase chain reaction is employed. Items that need consideration in the use of DNA-based detection methods include the specificity, sensitivity, matrix effects, internal reference DNA, availability of external reference materials, hemizygosity versus homozygosity, extrachromosomal DNA, and international harmonisation. For most protein-based methods, enzyme-linked immunosorbent assays with antibodies binding the novel protein are employed. Consideration should be given to the selection of the antigen bound by the antibody, accuracy, validation, and matrix effects. Currently, validation of detection methods for analysis of genetically modified organisms is taking place. In addition, new methodologies are developed, including the use of microarrays, mass spectrometry, and surface plasmon resonance. Challenges for GMO detection include the detection of transgenic material in materials with varying chromosome numbers. The existing and proposed regulatory EU requirements for traceability of genetically modified products fit within a broader tendency towards traceability of foods in general and, commercially, towards products that can be distinguished from each other. Traceability systems document the history of a product and may serve the purpose of both marketing and health protection. In this framework, segregation and identity preservation systems allow for the separation of genetically modified and non-modified products from "farm to fork". Implementation of these systems comes with specific technical requirements for each particular step of the food processing chain. In addition, the feasibility of traceability systems depends on a number of factors, including unique identifiers for each genetically modified product, detection methods, permissible levels of contamination, and financial costs. In conclusion, progress has been achieved in the field of sampling, detection, and traceability of genetically modified products, while some issues remain to be solved. For success, much will depend on the threshold level for adventitious contamination set by legislation. Copryright 2004 Elsevier Ltd.

Sophisticated Cloning, Fermentation, and Purification Technologies for an Enhanced Therapeutic Protein Production: A Review

PubMed Central

Gupta, Sanjeev K.; Shukla, Pratyoosh

2017-01-01

The protein productions strategies are crucial towards the development of application based research and elucidating the novel purification strategies for industrial production. Currently, there are few innovative avenues are studies for cloning, upstream, and purification through efficient bioprocess development. Such strategies are beneficial for industries as well as proven to be vital for effectual therapeutic protein development. Though, these techniques are well documented, but, there is scope of addition to current knowledge with novel and new approaches and it will pave new avenues in production of recombinant microbial and non-microbial proteins including secondary metabolites. In this review, we have focussed on the recent development in clone selection, various modern fermentation and purification technologies and future directions in these emerging areas. Moreover, we have also highlighted notable perspectives and challenges involved in the bioengineering of such proteins, including quality by design, gene editing and pioneering ideas. The biopharmaceutical industries continue to shift towards more flexible, automated platforms and economical product development, which in turn can help in developing the cost effective processes and affordable drug development for a large community. PMID:28725194

Forest Resources of the United States, 2012: a technical document supporting the Forest Service 2010 update of the RPA Assessment

Treesearch

Sonja N. Oswalt; W. Brad Smith; Patrick D. Miles; Scott A. Pugh

2014-01-01

Forest resource statistics from the 2010 Resources Planning Act (RPA) Assessment were updated to provide current information on the Nation's forests as a baseline for the 2015 national assessment. Resource tables present estimates of forest area, volume, mortality, growth, removals, and timber products output in various ways, such as by ownership, region, or State...

Development Of Fiber Optics For Passenger Car Applications

NASA Astrophysics Data System (ADS)

Steele, R. E.; Schmitt, H. J.

1987-12-01

The benefits of fiber optics for telecommunications and Local Area Networks (LANs) are well documented. The benefits to passenger car applications are not as clearly defined. This paper examines the differences between Telecommunications, LAN, and automotive point to point and network applications. Current production automotive applications of optics and fiber optics, automotive data communications trends, and both functional and non-functional requirements and constraints will be described.

Nanostructured Alloys as an Alternative to Copper-Beryllium

DTIC Science & Technology

2014-11-19

2014 Presented by Jonathan McCrea Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of...unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Advanced Materials Integran Technologies...requirements for current and future copper-beryllium alloy needs/ applications ● Demonstrate with three distinct product forms :  1) Bulk material for

A framework for developing research protocols for evaluation of microbial hazards and controls during production that pertain to the quality of agricultural water contacting fresh produce that may be consumed raw.

PubMed

Harris, Linda J; Bender, Jeff; Bihn, Elizabeth A; Blessington, Tyann; Danyluk, Michelle D; Delaquis, Pascal; Goodridge, Lawrence; Ibekwe, A Mark; Ilic, Sanja; Kniel, Kali; Lejeune, Jeffrey T; Schaffner, Donald W; Stoeckel, Don; Suslow, Trevor V

2012-12-01

Agricultural water may contact fresh produce during irrigation and/or when crop protection sprays (e.g., cooling to prevent sunburn, frost protection, and agrochemical mixtures) are applied. This document provides a framework for designing research studies that would add to our understanding of preharvest microbial food safety hazards and control measures pertaining to agricultural water. Researchers will be able to use this document to design studies, to anticipate the scope and detail of data required, and to evaluate previously published work. This document should also be useful for evaluating the strength of existing data and thus should aid in identifying future research needs. Use of this document by the research community may lead to greater consistency or comparability than currently exists among research studies, which may ultimately facilitate direct comparison of hazards and efficacy of controls among different commodities, conditions, and practices.

Gaalas/Gaas Solar Cell Process Study

NASA Technical Reports Server (NTRS)

Almgren, D. W.; Csigi, K. I.

1980-01-01

Available information on liquid phase, vapor phase (including chemical vapor deposition) and molecular beam epitaxy growth procedures that could be used to fabricate single crystal, heteroface, (AlGa) As/GaAs solar cells, for space applications is summarized. A comparison of the basic cost elements of the epitaxy growth processes shows that the current infinite melt LPE process has the lower cost per cell for an annual production rate of 10,000 cells. The metal organic chemical vapor deposition (MO-CVD) process has the potential for low cost production of solar cells but there is currently a significant uncertainty in process yield, i.e., the fraction of active material in the input gas stream that ends up in the cell. Additional work is needed to optimize and document the process parameters for the MO-CVD process.

Uranium Stable Isotopes: A Proxy For Productivity Or Ocean Oxygenation?

NASA Astrophysics Data System (ADS)

Severmann, S.

2015-12-01

Uranium elemental abundances in sediments have traditionally been used to reconstruct primary productivity and carbon flux in the ocean. 238U/235U isotope compositions, in contrast, are currently understood to reflect the extent of bottom water anoxia in the ocean. A review of our current understanding of authigenic U enrichment mechanism into reducing sediments suggests that a revision of this interpretation is warranted. Specifically, the current interpretation of U isotope effects in suboxic vs. anoxic deposits has not taken into account the well-documented linear relationship with organic C burial rates. Although organic C rain rates (i.e., surface productivity) and bottom water oxygenation are clearly related, distinction between these two environmental controls is conceptually important as it relates to the mechanism of enhanced C burial and ultimately the strength of the biological pump. Here we will review new and existing data to test the hypothesis that the isotope composition of authigenic U in reducing sediments are best described by their relationship with parameters related to organic carbon delivery and burial, rather than bottom water oxygen concentration.

Novel Hydrogen Production Systems Operative at Thermodynamic Extremes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gunsalus, Robert

2012-11-30

We have employed a suite of molecular, bioinformatics, and biochemical tools to interrogate the thermodynamically limiting steps of H{sub 2} production from fatty acids in syntrophic communities. We also developed a new microbial model system that generates high H{sub 2} concentrations (over 17% of the gas phase) with high H{sub 2} yields of over 3 moles H{sub 2} per mole glucose. Lastly, a systems-based study of biohydrogen production in model anaerobic consortia was performed to begin identifying key regulated steps as a precursor to modeling co-metabolism. The results of these studies significantly expand our ability to predict and model systemsmore » for H{sub 2} production in novel anaerobes that are currently very poorly documented or understood.« less

Variation in adverse drug reactions listed in product information for antidepressants and anticonvulsants, between the USA and Europe: a comparison review of paired regulatory documents.

PubMed

Cornelius, Victoria R; Liu, Kun; Peacock, Janet; Sauzet, Odile

2016-03-20

To compare consistency of adverse drug reaction (ADR) data in publicly available product information documents for brand drugs, between the USA and Europe. To assess the usefulness of information for prescribers and patients. A comparison review of product information documents for antidepressants and anticonvulsants concurrently marketed by the same pharmaceutical company in the USA and Europe. For each drug, data were extracted from the US Product Inserts and the European Summary of Product Characteristics documents between 09/2013 and 01/2015. Individuals contributing ADR information to product information documents. All ADRs reported in product information sections 5 and 6 (USA), and 4·4 and 4·8 (Europe). Twelve brand drugs--24 paired documents--were included. On average, there were 77 more ADRs reported in the USA compared with in the European product information document, with a median number of 201 ADRs (range: 65-425) and 114 (range: 56-265), respectively. More product information documents in the USA reported information on the source of evidence (10 vs 5) and risk (9 vs 5) for greater than 80% of ADRs included in the document. There was negligible information included regarding duration, severity, reversibility or recurrence of ADRs. On average, only 29% of ADR terms were reported in both paired documents. Product information documents contained a large number of ADRs, but lacked contextual data and information important to patients and prescribers, such as duration, severity and reversibility. The ADR profile was found to be inconsistently reported between the USA and Europe, for the same drug. Identifying, selecting, summarising and presenting multidimensional harm data should be underpinned by practical evidence-based guidelines. In order for prescribers to provide considered risk-benefit advice across competing drug therapies to patients, they need access to comprehensible and reliable ADR information. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Variation in adverse drug reactions listed in product information for antidepressants and anticonvulsants, between the USA and Europe: a comparison review of paired regulatory documents

PubMed Central

Cornelius, Victoria R; Liu, Kun; Peacock, Janet; Sauzet, Odile

2016-01-01

Objective To compare consistency of adverse drug reaction (ADR) data in publicly available product information documents for brand drugs, between the USA and Europe. To assess the usefulness of information for prescribers and patients. Design A comparison review of product information documents for antidepressants and anticonvulsants concurrently marketed by the same pharmaceutical company in the USA and Europe. Setting For each drug, data were extracted from the US Product Inserts and the European Summary of Product Characteristics documents between 09/2013 and 01/2015. Participants Individuals contributing ADR information to product information documents. Main outcomes measures All ADRs reported in product information sections 5 and 6 (USA), and 4·4 and 4·8 (Europe). Results Twelve brand drugs—24 paired documents—were included. On average, there were 77 more ADRs reported in the USA compared with in the European product information document, with a median number of 201 ADRs (range: 65–425) and 114 (range: 56–265), respectively. More product information documents in the USA reported information on the source of evidence (10 vs 5) and risk (9 vs 5) for greater than 80% of ADRs included in the document. There was negligible information included regarding duration, severity, reversibility or recurrence of ADRs. On average, only 29% of ADR terms were reported in both paired documents. Conclusions Product information documents contained a large number of ADRs, but lacked contextual data and information important to patients and prescribers, such as duration, severity and reversibility. The ADR profile was found to be inconsistently reported between the USA and Europe, for the same drug. Identifying, selecting, summarising and presenting multidimensional harm data should be underpinned by practical evidence-based guidelines. In order for prescribers to provide considered risk-benefit advice across competing drug therapies to patients, they need access to comprehensible and reliable ADR information. PMID:26996819

Improving the Product Documentation Process of a Small Software Company

NASA Astrophysics Data System (ADS)

Valtanen, Anu; Ahonen, Jarmo J.; Savolainen, Paula

Documentation is an important part of the software process, even though it is often neglected in software companies. The eternal question is how much documentation is enough. In this article, we present a practical implementation of lightweight product documentation process resulting from SPI efforts in a small company. Small companies’ financial and human resources are often limited. The documentation process described here, offers a template for creating adequate documentation consuming minimal amount of resources. The key element of the documentation process is an open source web-based bugtracking system that was customized to be used as a documentation tool. The use of the tool enables iterative and well structured documentation. The solution best serves the needs of a small company with off-the-shelf software products and striving for SPI.

Optimal molecular profiling of tissue and tissue components: defining the best processing and microdissection methods for biomedical applications.

PubMed

Bova, G Steven; Eltoum, Isam A; Kiernan, John A; Siegal, Gene P; Frost, Andra R; Best, Carolyn J M; Gillespie, John W; Emmert-Buck, Michael R

2005-01-01

Isolation of well-preserved pure cell populations is a prerequisite for sound studies of the molecular basis of pancreatic malignancy and other biological phenomena. This chapter reviews current methods for obtaining anatomically specific signals from molecules isolated from tissues, a basic requirement for productive linking of phenotype and genotype. The quality of samples isolated from tissue and used for molecular analysis is often glossed-over or omitted from publications, making interpretation and replication of data difficult or impossible. Fortunately, recently developed techniques allow life scientists to better document and control the quality of samples used for a given assay, creating a foundation for improvement in this area. Tissue processing for molecular studies usually involves some or all of the following steps: tissue collection, gross dissection/identification, fixation, processing/embedding, storage/archiving, sectioning, staining, microdissection/annotation, and pure analyte labeling/identification. High-quality tissue microdissection does not necessarily mean high-quality samples to analyze. The quality of biomaterials obtained for analysis is highly dependent on steps upstream and downstream from tissue microdissection. We provide protocols for each of these steps, and encourage you to improve upon these. It is worth the effort of every laboratory to optimize and document its technique at each stage of the process, and we provide a starting point for those willing to spend the time to optimize. In our view, poor documentation of tissue and cell type of origin and the use of nonoptimized protocols is a source of inefficiency in current life science research. Even incremental improvement in this area will increase productivity significantly.

36 CFR § 703.16 - Policy on presentation of testimony and production of documents.

Code of Federal Regulations, 2013 CFR

2013-07-01

... LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.16 Policy on presentation of testimony and production of documents. No Library of Congress employee may provide testimony or...

Machine intelligence applications to securities production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, C.K.

1987-01-01

The production of security documents provides a cache of interesting problems ranging across a broad spectrum. Some of the problems do not have rigorous scientific solutions available at this time and provide opportunities for less structured approaches such as AI. AI methods can be used in conjunction with traditional scientific and computational methods. The most productive applications of AI occur when this marriage of methods can be carried out without motivation to prove that one method is better than the other. Fields such as ink chemistry and technology, and machine inspection of graphic arts printing offer interesting challenges which willmore » continue to intrigue current and future generations of researchers into the 21st century.« less

Global farm animal production and global warming: impacting and mitigating climate change.

PubMed

Koneswaran, Gowri; Nierenberg, Danielle

2008-05-01

The farm animal sector is the single largest anthropogenic user of land, contributing to many environmental problems, including global warming and climate change. The aim of this study was to synthesize and expand upon existing data on the contribution of farm animal production to climate change. We analyzed the scientific literature on farm animal production and documented greenhouse gas (GHG) emissions, as well as various mitigation strategies. An analysis of meat, egg, and milk production encompasses not only the direct rearing and slaughtering of animals, but also grain and fertilizer production for animal feed, waste storage and disposal, water use, and energy expenditures on farms and in transporting feed and finished animal products, among other key impacts of the production process as a whole. Immediate and far-reaching changes in current animal agriculture practices and consumption patterns are both critical and timely if GHGs from the farm animal sector are to be mitigated.

Patient-Focused Drug Development: A New Direction for Collaboration.

PubMed

Perfetto, Eleanor M; Burke, Laurie; Oehrlein, Elisabeth M; Epstein, Robert S

2015-01-01

Patient-Focused Drug Development (PFDD) is a new initiative from the Food and Drug Administration (FDA) intended to bring patient perspectives into an earlier stage of product development. The goal is that patients will be able to provide context for benefit-risk assessments and input to review divisions, and also aid in the development of new assessment tools, study endpoints, and risk communications. This paper provides a summary on what is known to date about FDA's PFDD initiative and describes implications for patients, researchers, payers, and the biopharmaceutical industry. It also provides a roadmap for stakeholders to consider in defining their role in and in shaping PFDD's direction, and for expanding PFDD principles to conditions beyond the current 20 under FDA consideration. A search was conducted of the peer-reviewed and gray literature using PubMed and Google. This included laws, FDA guidance documents, the peer-reviewed literature, and FDA presentations for content relevant to the search term "patient-focused drug development." Currently, FDA activities within PFDD are limited to gaining patient insights through 20 disease-specific meetings. However, many stakeholders see the initiative much more generally as representing a broad shift toward patient centeredness in biopharmaceutical product development. Depending upon the trajectory taken and whether or not all PFDD aims are eventually addressed, the initiative has the potential to change product development in fundamental ways. Further research should explore how patient input on disease manifestation and treatment options is best ascertained from patients and documented before initiating and during drug development.

Observed impact of upwelling events on water properties and biological activity off the southwest coast of New Caledonia.

PubMed

Ganachaud, Alexandre; Vega, Andrés; Rodier, Martine; Dupouy, Cécile; Maes, Christophe; Marchesiello, Patrick; Eldin, Gerard; Ridgway, Ken; Le Borgne, Robert

2010-01-01

The upwelling events that follow strong trade wind episodes have been described in terms of their remarkable signature in the sea surface temperature southwest off New Caledonia. Upwelling brings deeper, and colder waters to the surface, causing 2-4 degrees C drops in temperature in a few hours, followed by a slower relaxation over several days. Upwelling may sporadically bring nutrients to the surface under certain conditions, and increase the biological productivity. Two multidisciplinary hydrographic cruises allow the impact of upwelling on the chemical and biological properties of the water to be documented. Both cruises took place in austral summer (December 2004 and December 2005), but the first cruise occurred during a strong upwelling event, while the second cruise occurred in calm conditions. The water properties and planktonic composition show important contrasts, with a strong southeastward current (the "ALIS current of New Caledonia") competing with the upwelling system. Our analysis suggests that, while observed productivities are far less than those of typical upwelling systems, some wind events in New Caledonia may contribute to biological activity. A currentmeter mooring, deployed during the second cruise, documents the ocean response to a changing wind field and the local impact of upwelling on currents and temperatures on the water column. The results are discussed, with the help of climatology, Argo float profiler data, satellite data and of a high-resolution numerical simulation. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Arctic Alaska’s Lower Cretaceous (Hauterivian and Barremian) mudstone succession - Linking lithofacies, texture, and geochemistry to marine processes: Chapter B in Studies by the U.S. Geological Survey in Alaska, vol. 15

USGS Publications Warehouse

Keller, Margaret A.; Macquaker, Joe H.S.

2015-01-01

Our results document the variation in facies and textures of the Hauterivian and Barremian Lower Cretaceous mudstone succession of Arctic Alaska. Comparison of these characteristics to the products of modern processes on the North Slope of Alaska, in the Beaufort Sea, and elsewhere suggest that this succession formed primarily from depositional processes related to seasonal sea ice with intermittent fluvial-sourced sediment deposited by density currents and episodic erosion and reworking by storms and other currents.

DOD Renewable Energy Projects: Improved Guidance Needed for Analyzing and Documenting Costs and Benefits

DTIC Science & Technology

2016-09-01

on DOD installations have included electricity-generating technologies such as solar photovoltaic arrays, wind turbines , and burning of landfill...buildings, laboratories, and aircraft maintenance depots. Operational energy is the energy required for training, moving, and sustaining military...and the Production Tax Credit— which provides a tax credit currently equal to 2.3 cents per kilowatt-hour for energy produced from wind and certain

Increased importance of the documented development stage in process validation.

PubMed

Mohammed-Ziegler, Ildikó; Medgyesi, Ildikó

2012-07-01

Current trends in pharmaceutical quality assurance moved when the Federal Drug Administration (FDA) of the USA published its new guideline on process validation in 2011. This guidance introduced the lifecycle approach of process validation. In this short communication some typical changes from the point of view of practice of API production are addressed in the light of inspection experiences. Some details are compared with the European regulations.

Americium-Curium Stabilization - 5'' Cylindrical Induction Melter System Design Basis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Witt, D.C.

1999-11-08

Approximately 11,000 liters (3,600) gallons of solution containing isotopes of Am and Cm are currently stored in F-Canyon Tank 17.1. These isotopes were recovered during plutonium-242 production campaigns in the mid- and late-1970s. Experimental work for the project began in 1995 by the Savannah River Technology Center (SRTC). Details of the process are given in the various sections of this document.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fidler, Michal; Capece, John; Hanlon, Edward

Objective of the presentation is to document land use and water use implications of biomass production to demonstrate the overall resources implications associated with bioethanol production for Florida’s transportation sector needs. Rationale for using biofuels (BF) is explained, so are advantages & challenges of BF production and use. Land use changes (LUC) in Florida are presented and consequences outlined. It is documented that Florida’s agricultural land is a very limited resource, with only 0.43 ac/person comparing to the global average of 1.71 ac/person. The direct relation of increased biofuels production causing increased water use is explained. Favorable climate, water resources,more » advanced research, traditional leading agricultural role, minor oil reserves, no refineries and increasing energy demands are the main reasons why Florida considers pursuing BF production in large scale. Eight various bioethanol crops produced in Florida were considered in this study (Miscanthus, Switchgrass, Sweet Sorghum, Corn, Elephantgrass, Sugarcane, Energycane, Eucalyptus). Biomass yield and bioethanol yield of these crops are documented. Bioethanol needs of Florida are estimated and related land requirements for the needed bioethanol production calculated. Projections for various bioethanol blends (E15 to E85) are then presented. Finally, water demand for biofuels production is quantified. It is concluded that land use requirement for production of all ethanol in E85 fuel blend in Florida is roughly the same as the total available ag land in Florida for the best yielding biofuels crops (energycane, eucalyptus). Water demand for production of all ethanol needed for E100 would increase current overall water consumption in Florida between 65% and 100% for the most common biofuels crops. Vehicular energy is only 33% of Floridians energy consumption, so even all Florida’s agricultural land was given up for biofuels, it would still produce only 33% of Florida’s total energy needs. Still, bioethanol (primarily cellulosic) produced in Florida has a potential to meet a significant portion of the State’s transportation needs. Assuming no change in food production and consumption habits in Florida, the likely result of biofuels sector expansion would be the conversion of natural lands or low-intensity agricultural lands into high-intensity biomass production and the associated increased water consumption and water quality implications.« less

6 CFR 5.45 - Procedure when testimony or production of documents is sought; general.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Procedure when testimony or production of... Procedure when testimony or production of documents is sought; general. (a) If official information is... requiring oral testimony, and identification of potentially relevant documents. (c) The appropriate...

22 CFR 401.22 - Attendance of witnesses and production of documents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Attendance of witnesses and production of documents. 401.22 Section 401.22 Foreign Relations INTERNATIONAL JOINT COMMISSION, UNITED STATES AND CANADA RULES OF PROCEDURE Applications § 401.22 Attendance of witnesses and production of documents. (a...

22 CFR 401.22 - Attendance of witnesses and production of documents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Attendance of witnesses and production of documents. 401.22 Section 401.22 Foreign Relations INTERNATIONAL JOINT COMMISSION, UNITED STATES AND CANADA RULES OF PROCEDURE Applications § 401.22 Attendance of witnesses and production of documents. (a...

22 CFR 401.22 - Attendance of witnesses and production of documents.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Attendance of witnesses and production of documents. 401.22 Section 401.22 Foreign Relations INTERNATIONAL JOINT COMMISSION, UNITED STATES AND CANADA RULES OF PROCEDURE Applications § 401.22 Attendance of witnesses and production of documents. (a...

22 CFR 401.22 - Attendance of witnesses and production of documents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Attendance of witnesses and production of documents. 401.22 Section 401.22 Foreign Relations INTERNATIONAL JOINT COMMISSION, UNITED STATES AND CANADA RULES OF PROCEDURE Applications § 401.22 Attendance of witnesses and production of documents. (a...

AgRISTARS: Foreign commodity production forecasting. Project test reports document, volume 1. [using North Dakota, South Dakota, Montana, and Minnesota

NASA Technical Reports Server (NTRS)

Waggoner, J. T.; Phinney, D. E. (Principal Investigator)

1981-01-01

Foreign Commodity Production Forecasting testing activities through June 1981 are documented. A log of test reports is presented. Standard documentation sets are included for each test. The documentation elements presented in each set are summarized.

Evaluation of scientific periodicals and the Brazilian production of nursing articles.

PubMed

Erdmann, Alacoque Lorenzini; Marziale, Maria Helena Palucci; Pedreira, Mavilde da Luz Gonçalves; Lana, Francisco Carlos Félix; Pagliuca, Lorita Marlena Freitag; Padilha, Maria Itayra; Fernandes, Josicelia Dumêt

2009-01-01

This study aimed to identify nursing journals edited in Brazil indexed in the main bibliographic databases in the areas of health and nursing. It also aimed to classify the production of nursing graduate programs in 2007 according to the QUALIS/CAPES criteria used to classify scientific periodicals that disseminate the intellectual production of graduate programs in Brazil. This exploratory study used data from reports and documents available from CAPES to map scientific production and from searching the main international and national indexing databases. The findings from this research can help students, professors and coordinators of graduate programs in several ways: to understand the criteria of classifying periodicals; to be aware of the current production of graduate programs in the area of nursing; and to provide information that authors can use to select periodicals in which to publish their articles.

Health Promotion and Healthier Products Increase Vending Purchases: A Randomized Factorial Trial.

PubMed

Hua, Sophia V; Kimmel, Lisa; Van Emmenes, Michael; Taherian, Rafi; Remer, Geraldine; Millman, Adam; Ickovics, Jeannette R

2017-07-01

The current food environment has a high prevalence of nutrient-sparse foods and beverages, most starkly seen in vending machine offerings. There are currently few studies that explore different interventions that might lead to healthier vending machine purchases. To examine how healthier product availability, price reductions, and/or promotional signs affect sales and revenue of snack and beverage vending machines. A 2×2×2 factorial randomized controlled trial was conducted. Students, staff, and employees on a university campus. All co-located snack and beverage vending machines (n=56, 28 snack and 28 beverage) were randomized into one of eight conditions: availability of healthier products and/or 25% price reduction for healthier items and/or promotional signs on machines. Aggregate sales and revenue data for the 5-month study period (February to June 2015) were compared with data from the same months 1 year prior. Analyses were conducted July 2015. The change in units sold and revenue between February through June 2014 and 2015. Linear regression models (main effects and interaction effects) and t test analyses were performed. The interaction between healthier product guidelines and promotional signs in snack vending machines documented increased revenue (P<0.05). Beverage machines randomized to meet healthier product guidelines documented increased units sold (P<0.05) with no revenue change. Price reductions alone had no effect, nor were there any effects for the three-way interaction of the factors. Examining top-selling products for all vending machines combined, pre- to postintervention, we found an overall shift to healthier purchasing. When healthier vending snacks are available, promotional signs are also important to ensure consumers purchase those items in greater amounts. Mitigating potential loss in profits is essential for sustainability of a healthier food environment. Copyright © 2017 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

Clinical practice guidelines and consensus statements in oncology--an assessment of their methodological quality.

PubMed

Jacobs, Carmel; Graham, Ian D; Makarski, Julie; Chassé, Michaël; Fergusson, Dean; Hutton, Brian; Clemons, Mark

2014-01-01

Consensus statements and clinical practice guidelines are widely available for enhancing the care of cancer patients. Despite subtle differences in their definition and purpose, these terms are often used interchangeably. We systematically assessed the methodological quality of consensus statements and clinical practice guidelines published in three commonly read, geographically diverse, cancer-specific journals. Methods Consensus statements and clinical practice guidelines published between January 2005 and September 2013 in Current Oncology, European Journal of Cancer and Journal of Clinical Oncology were evaluated. Each publication was assessed using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) rigour of development and editorial independence domains. For assessment of transparency of document development, 7 additional items were taken from the Institute of Medicine's standards for practice guidelines and the Journal of Clinical Oncology guidelines for authors of guidance documents. Consensus statements and clinical practice guidelines published between January 2005 and September 2013 in Current Oncology, European Journal of Cancer and Journal of Clinical Oncology were evaluated. Each publication was assessed using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) rigour of development and editorial independence domains. For assessment of transparency of document development, 7 additional items were taken from the Institute of Medicine's standards for practice guidelines and the Journal of Clinical Oncology guidelines for authors of guidance documents. Thirty-four consensus statements and 67 clinical practice guidelines were evaluated. The rigour of development score for consensus statements over the three journals was 32% lower than that of clinical practice guidelines. The editorial independence score was 15% lower for consensus statements than clinical practice guidelines. One journal scored consistently lower than the others over both domains. No journals adhered to all the items related to the transparency of document development. One journal's consensus statements endorsed a product made by the sponsoring pharmaceutical company in 64% of cases. Guidance documents are an essential part of oncology care and should be subjected to a rigorous and validated development process. Consensus statements had lower methodological quality than clinical practice guidelines using AGREE II. At a minimum, journals should ensure that that all consensus statements and clinical practice guidelines adhere to AGREE II criteria. Journals should consider explicitly requiring guidelines to declare pharmaceutical company sponsorship and to identify the sponsor's product to enhance transparency.

Demonstration of a Real Time Capability to Produce Tidal Heights and Currents for Naval Operational Use: A Cast Study for the West Coast of Africa (Liberia)

NASA Technical Reports Server (NTRS)

Mehra, Avichal; Anantharaj, Valentine; Payne, Steve; Kantha, Lakshmi

1996-01-01

This report documents an existing capability to produce operationally relevant products on sea level and currents from a tides/storm surge model for any coastal region around the world within 48 hours from the time of the request. The model is ready for transition to the Naval Oceanographic Office (NAVOCEANO) for potential contingency use anywhere around the world. A recent application to naval operations offshore Liberia illustrates this. Mississippi State University, in collaboration with the University of Colorado and NAVOCEANO, successfully deployed the Colorado University Rapidly Relocatable Nestable Tides and Storm Surge (CURReNTSS) model that predicts sea surface height, tidal currents and storm surge, and provided operational products on tidal sea level and currents in the littoral region off south-western coast of Africa. This report summarizes the results of this collaborative effort in an actual contingency use of the relocatable model, summarizes the lessons learned, and provides recommendations for further evaluation and transition of this modeling capability to operational use.

Prospects for Ukrainian ferrous metals in the post-soviet period

USGS Publications Warehouse

Levine, R.M.; Bond, A.R.

1998-01-01

Two specialists on the mineral industries of the countries of the former USSR survey current problems confronting producers of ferrous metals in Ukraine and future prospects for domestic production and exports. A series of observations documenting the importance of ferrous metals production to Ukraine's economy is followed by sections describing investment plans and needs in the sector, and the role played by Ukraine within the iron and steel industry of the Soviet Union. The focus then turns to assessment of the current regional and global competitive position of Ukrainian producers for each of the major commodities of the sector-iron ore, manganese ore, ferroalloys, steel, and the products of the machine manufacturing and metal working industries. In conclusion, the paper discusses a potential regional industrial integration strategy analogous to that employed in the United States' Great Lakes/Midwest region, which possesses similar types of iron ore deposits and similar transport cost advantages and metallurgical and manufacturing industries. Journal of Economic Literature, Classification Numbers: F14, L61, L72. 1 table, 26 references.

47 CFR 1.325 - Discovery and production of documents and things for inspection, copying, or photographing.

Code of Federal Regulations, 2011 CFR

2011-10-01

... with the presiding officer): (i) All formation and organizational documents, including articles of..., minority/female status, and the like; (xi) All documents relating to commitments to divest other media... exchanged pursuant to the Standardized Document Production Order, the following information must also be...

47 CFR 1.325 - Discovery and production of documents and things for inspection, copying, or photographing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... with the presiding officer): (i) All formation and organizational documents, including articles of..., minority/female status, and the like; (xi) All documents relating to commitments to divest other media... exchanged pursuant to the Standardized Document Production Order, the following information must also be...

A Four Channel Beam Current Monitor Data Acquisition System Using Embedded Processors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wheat, Jr., Robert Mitchell; Dalmas, Dale A.; Dale, Gregory E.

2015-08-11

Data acquisition from multiple beam current monitors is required for electron accelerator production of Mo-99. A two channel system capable of recording data from two beam current monitors has been developed, is currently in use, and is discussed below. The development of a cost-effective method of extending this system to more than two channels and integrating of these measurements into an accelerator control system is the main focus of this report. Data from these current monitors is digitized, processed, and stored by a digital data acquisition system. Limitations and drawbacks with the currently deployed digital data acquisition system have beenmore » identified as have been potential solutions, or at least improvements, to these problems. This report will discuss and document the efforts we've made in improving the flexibility and lowering the cost of the data acquisition system while maintaining the minimum requirements.« less

6 CFR 5.44 - Testimony and production of documents prohibited unless approved by appropriate Department...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Testimony and production of documents prohibited... in Litigation § 5.44 Testimony and production of documents prohibited unless approved by appropriate... or request, including in connection with any litigation, provide oral or written testimony by...

40 CFR 80.106 - Product transfer documents.

Code of Federal Regulations, 2012 CFR

2012-07-01

... gasoline being transferred; (iv) The location of the gasoline at the time of the transfer; (v) The date of... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Product transfer documents. 80.106... (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Anti-Dumping § 80.106 Product transfer documents. (a)(1...

Model documentation: Renewable Fuels Module of the National Energy Modeling System

NASA Astrophysics Data System (ADS)

1994-04-01

This report documents the objectives, analytical approach, and design of the National Energy Modeling System (NEMS) Renewable Fuels Module (RFM) as it related to the production of the 1994 Annual Energy Outlook (AEO94) forecasts. The report catalogues and describes modeling assumptions, computational methodologies, data inputs, and parameter estimation techniques. A number of offline analyses used in lieu of RFM modeling components are also described. This documentation report serves two purposes. First, it is a reference document for model analysts, model users, and the public interested in the construction and application of the RFM. Second, it meets the legal requirement of the Energy Information Administration (EIA) to provide adequate documentation in support of its models. The RFM consists of six analytical submodules that represent each of the major renewable energy resources -- wood, municipal solid waste (MSW), solar energy, wind energy, geothermal energy, and alcohol fuels. Of these six, four are documented in the following chapters: municipal solid waste, wind, solar and biofuels. Geothermal and wood are not currently working components of NEMS. The purpose of the RFM is to define the technological and cost characteristics of renewable energy technologies, and to pass these characteristics to other NEMS modules for the determination of mid-term forecasted renewable energy demand.

Modular Electronics for Flash Memory Production

DTIC Science & Technology

2011-12-28

DEFENSE TECHNICAL INFORMATION CENTER ImuM ktkUmlimäj DTICfhas determined on oc öf^H AJI that this Technical Document has the Distribution...the second harmonic (8I2/8V2), and a normalization to remove the scale of the measured current. The red dashed lines represent notable vibrational...superimposed as red dashed lines. The agreement between the two spectroscopies is conclusive that we have successfully put our OPE derivative into the gap

Unique strategies for technical information management at Johnson Space Center

NASA Technical Reports Server (NTRS)

Krishen, Vijay

1994-01-01

In addition to the current NASA manned programs, the maturation of Space Station and the introduction of the Space Exploration programs are anticipated to add substantially to the number and variety of data and documentation at NASA Johnson Space Center (JSC). This growth in the next decade has been estimated at five to ten fold compared to the current numbers. There will be an increased requirement for the tracking and currency of space program data and documents with National pressures to realize economic benefits from the research and technological developments of space programs. From a global perspective the demand for NASA's technical data and documentation is anticipated to increase at local, national, and international levels. The primary users will be government, industry, and academia. In our present national strategy, NASA's research and technology will assume a great role in the revitalization of the economy and gaining international competitiveness. Thus, greater demand will be placed on NASA's data and documentation resources. In this paper the strategies and procedures developed by DDMS, Inc., to accommodate the present and future information utilization needs are presented. The DDMS, Inc., strategies and procedures rely on understanding user requirements, library management issues, and technological applications for acquiring, searching, storing, and retrieving specific information accurately and quickly. The proposed approach responds to changing customer requirements and product deliveries. The unique features of the proposed strategy include: (1) To establish customer driven data and documentation management through an innovative and unique methods to identify needs and requirements. (2) To implement a structured process which responds to user needs, aimed at minimizing costs and maximizing services, resulting in increased productivity. (3) To provide a process of standardization of services and procedures. This standardization is the central theme of the strategic approach. It will allow Division level Data and Documentation Libraries (DDL's) to function independently and optimize efficiency at the Directorate level. This process also facilitates interconnectivity between Division level DDL's and makes them transparent to the users. (4) To implement the process of 'cost savings', and at the same time the objective is to gain substantial improvement in the organization, categorization, and preservation of JSC-generated data and documentation, and (5) To find, locate, retrace, restore, and preserve the Center-generated crucial scientific and technical information that has been and is being provided by the engineers and scientists of JSC. This is important to the preservation of 'lessons learned'. Preliminary estimates of the possible cost savings which will result from the implementation of this process will also be discussed in this paper.

File Specification for GEOS-5 FP (Forward Processing)

NASA Technical Reports Server (NTRS)

Lucchesi, R.

2013-01-01

The GEOS-5 FP Atmospheric Data Assimilation System (GEOS-5 ADAS) uses an analysis developed jointly with NOAA's National Centers for Environmental Prediction (NCEP), which allows the Global Modeling and Assimilation Office (GMAO) to take advantage of the developments at NCEP and the Joint Center for Satellite Data Assimilation (JCSDA). The GEOS-5 AGCM uses the finite-volume dynamics (Lin, 2004) integrated with various physics packages (e.g, Bacmeister et al., 2006), under the Earth System Modeling Framework (ESMF) including the Catchment Land Surface Model (CLSM) (e.g., Koster et al., 2000). The GSI analysis is a three-dimensional variational (3DVar) analysis applied in grid-point space to facilitate the implementation of anisotropic, inhomogeneous covariances (e.g., Wu et al., 2002; Derber et al., 2003). The GSI implementation for GEOS-5 FP incorporates a set of recursive filters that produce approximately Gaussian smoothing kernels and isotropic correlation functions. The GEOS-5 ADAS is documented in Rienecker et al. (2008). More recent updates to the model are presented in Molod et al. (2011). The GEOS-5 system actively assimilates roughly 2 × 10(exp 6) observations for each analysis, including about 7.5 × 10(exp 5) AIRS radiance data. The input stream is roughly twice this volume, but because of the large volume, the data are thinned commensurate with the analysis grid to reduce the computational burden. Data are also rejected from the analysis through quality control procedures designed to detect, for example, the presence of cloud. To minimize the spurious periodic perturbations of the analysis, GEOS-5 FP uses the Incremental Analysis Update (IAU) technique developed by Bloom et al. (1996). More details of this procedure are given in Appendix A. The assimilation is performed at a horizontal resolution of 0.3125-degree longitude by 0.25- degree latitude and at 72 levels, extending to 0.01 hPa. All products are generated at the native resolution of the horizontal grid. The majority of data products are time-averaged, but four instantaneous products are also available. Hourly data intervals are used for two-dimensional products, while 3-hourly intervals are used for three-dimensional products. These may be on the model's native 72-layer vertical grid or at 42 pressure surfaces extending to 0.1 hPa. This document describes the gridded output files produced by the GMAO near real-time operational FP, using the most recent version of the GEOS-5 assimilation system. Additional details about variables listed in this file specification can be found in a separate document, the GEOS-5 File Specification Variable Definition Glossary. Documentation about the current access methods for products described in this document can be found on the GMAO products page: http://gmao.gsfc.nasa.gov/products/.

International laser-safety regulations: a status update

NASA Astrophysics Data System (ADS)

Weiner, Robert M.

1990-07-01

There is an increase in international laser safety requirements as part of the emphasis on world-wide standardization of products and regulations. In particular the documents which will evolve from the 1992 consolidation efforts of the European Community (EC) will impact both laser manufacturers and users. This paper provides a discussion of the current status of the various laser radiation standards. NORTH AMERICAN REQUIREMENTS United States Requirements on manufacturers from the Food and Drug Administration (FDA) have been in effect since 1975. The Center for Devices and Radiological Health (CDRH) within that agency ensures that these mandatory requirements [1] are satisfied. The CDRH regulations include the division of products into classes depending on their potential for hazard criteria for power measurement and requirements for product features labels and manuals and records and reports. Manufacturers must test products and certify that they comply with the CDRH requirements. User requirements are found in a standard published by the American National Standards Institute (ANSI) and in requirements from several individual states. Specific ANSI standards have also been published for fiber communications systems [34] and for lasers in medical applications [35]. Please note that the Appendix includes additional information on the standards discussed in this paper including sources for obtaining the documents. Canada In the past Canada has had requirements for two specified product categories (bar code scanners and educational lasers) [26 These will be replaced

[International trend of guidance for nanomaterial risk assessment].

PubMed

Hirose, Akihiko

2013-01-01

In the past few years, several kinds of opinions or recommendations on the nanomaterial safety assessment have been published from international or national bodies. Among the reports, the first practical guidance of risk assessment from the regulatory body was published from the European Food Safety Authorities in May 2011, which included the determination of exposure scenario and toxicity testing strategy. In October 2011, European Commission (EC) adopted the definition of "nanomaterial" for regulation. And more recently, Scientific Committee on Consumer Safety of EC released guidance for assessment of nanomaterials in cosmetics in June 2012. A series of activities in EU marks an important step towards realistic safety assessment of nanomaterials. On the other hand, the US FDA announced a draft guidance for industry in June 2011, and then published draft guidance documents for both "Cosmetic Products" and "Food Ingredients and Food Contact Substances" in April 2012. These draft documents do not restrictedly define the physical properties of nanomaterials, but when manufacturing changes alter the dimensions, properties, or effects of an FDA-regulated product, the products are treated as new products. Such international movements indicate that most of nanomaterials with any new properties would be assessed or regulated as new products by most of national authorities in near future, although the approaches are still case by case basis. We will introduce such current international activities and consideration points for regulatory risk assessment.

Spam comments prediction using stacking with ensemble learning

NASA Astrophysics Data System (ADS)

Mehmood, Arif; On, Byung-Won; Lee, Ingyu; Ashraf, Imran; Choi, Gyu Sang

2018-01-01

Illusive comments of product or services are misleading for people in decision making. The current methodologies to predict deceptive comments are concerned for feature designing with single training model. Indigenous features have ability to show some linguistic phenomena but are hard to reveal the latent semantic meaning of the comments. We propose a prediction model on general features of documents using stacking with ensemble learning. Term Frequency/Inverse Document Frequency (TF/IDF) features are inputs to stacking of Random Forest and Gradient Boosted Trees and the outputs of the base learners are encapsulated with decision tree to make final training of the model. The results exhibits that our approach gives the accuracy of 92.19% which outperform the state-of-the-art method.

Diffractive optical variable image devices generated by maskless interferometric lithography for optical security

NASA Astrophysics Data System (ADS)

Cabral, Alexandre; Rebordão, José M.

2011-05-01

In optical security (protection against forgery and counterfeit of products and documents) the problem is not exact reproduction but the production of something sufficiently similar to the original. Currently, Diffractive Optically Variable Image Devices (DOVID), that create dynamic chromatic effects which may be easily recognized but are difficult to reproduce, are often used to protect important products and documents. Well known examples of DOVID for security are 3D or 2D/3D holograms in identity documents and credit cards. Others are composed of shapes with different types of microstructures yielding by diffraction to chromatic dynamic effects. A maskless interferometric lithography technique to generate DOVIDs for optical security is presented and compared to traditional techniques. The approach can be considered as a self-masking focused holography on planes tilted with respect to the reference optical axes of the system, and is based on the Scheimpflug and Hinge rules. No physical masks are needed to ensure optimum exposure of the photosensitive film. The system built to demonstrate the technique relies on the digital mirrors device MOEMS technology from Texas Instruments' Digital Light Processing. The technique is linear on the number of specified colors and does not depend either on the area of the device or the number of pixels, factors that drive the complexity of dot-matrix based systems. The results confirmed the technique innovation and capabilities in the creation of diffractive optical elements for security against counterfeiting and forgery.

Air and smear sample calculational tool for Fluor Hanford Radiological control

DOE Office of Scientific and Technical Information (OSTI.GOV)

BAUMANN, B.L.

2003-07-11

A spreadsheet calculation tool was developed to automate the calculations performed for determining the concentration of airborne radioactivity and smear counting as outlined in HNF-13536, Section 5.2.7, ''Analyzing Air and Smear Samples''. This document reports on the design and testing of the calculation tool. Radiological Control Technicians (RCTs) will save time and reduce hand written and calculation errors by using an electronic form for documenting and calculating work place air samples. Current expectations are RCTs will perform an air sample and collect the filter or perform a smear for surface contamination. RCTs will then survey the filter for gross alphamore » and beta/gamma radioactivity and with the gross counts utilize either hand calculation method or a calculator to determine activity on the filter. The electronic form will allow the RCT with a few key strokes to document the individual's name, payroll, gross counts, instrument identifiers; produce an error free record. This productivity gain is realized by the enhanced ability to perform mathematical calculations electronically (reducing errors) and at the same time, documenting the air sample.« less

49 CFR 510.8 - Written requests for the production of documents and things.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and things. 510.8 Section 510.8 Transportation Other Regulations Relating to Transportation (Continued... § 510.8 Written requests for the production of documents and things. The NHTSA may, by the issuance of a... § 510.7. Written requests for the production of documents and things are issued by the Chief Counsel...

Engineering visualization utilizing advanced animation

NASA Technical Reports Server (NTRS)

Sabionski, Gunter R.; Robinson, Thomas L., Jr.

1989-01-01

Engineering visualization is the use of computer graphics to depict engineering analysis and simulation in visual form from project planning through documentation. Graphics displays let engineers see data represented dynamically which permits the quick evaluation of results. The current state of graphics hardware and software generally allows the creation of two types of 3D graphics. The use of animated video as an engineering visualization tool is presented. The engineering, animation, and videography aspects of animated video production are each discussed. Specific issues include the integration of staffing expertise, hardware, software, and the various production processes. A detailed explanation of the animation process reveals the capabilities of this unique engineering visualization method. Automation of animation and video production processes are covered and future directions are proposed.

Tobacco industry consumer research on smokeless tobacco users and product development.

PubMed

Mejia, Adrienne B; Ling, Pamela M

2010-01-01

Since 2006, RJ Reynolds (RJR) and Philip Morris have both introduced new smokeless "snus" tobacco products. We analyzed previously secret tobacco industry documents describing the history of RJR and Philip Morris's consumer research, smokeless product development, and marketing strategies. We found that RJR had invested in smokeless research, development, and marketing since 1968. RJR first targeted low-income males through sampling and sponsorship at fishing, rodeo, and baseball events, and through advertising portraying the user as "hard working." In the early 1990s, Philip Morris and RJR hoped to attract more urban, female smokeless users. The current "snus" campaigns appear to appeal to these targeted consumers and smokers in smoke-free environments. These efforts may expand the tobacco market and undermine smoking cessation.

Healthcare software assurance.

PubMed

Cooper, Jason G; Pauley, Keith A

2006-01-01

Software assurance is a rigorous, lifecycle phase-independent set of activities which ensure completeness, safety, and reliability of software processes and products. This is accomplished by guaranteeing conformance to all requirements, standards, procedures, and regulations. These assurance processes are even more important when coupled with healthcare software systems, embedded software in medical instrumentation, and other healthcare-oriented life-critical systems. The current Food and Drug Administration (FDA) regulatory requirements and guidance documentation do not address certain aspects of complete software assurance activities. In addition, the FDA's software oversight processes require enhancement to include increasingly complex healthcare systems such as Hospital Information Systems (HIS). The importance of complete software assurance is introduced, current regulatory requirements and guidance discussed, and the necessity for enhancements to the current processes shall be highlighted.

Healthcare Software Assurance

PubMed Central

Cooper, Jason G.; Pauley, Keith A.

2006-01-01

Software assurance is a rigorous, lifecycle phase-independent set of activities which ensure completeness, safety, and reliability of software processes and products. This is accomplished by guaranteeing conformance to all requirements, standards, procedures, and regulations. These assurance processes are even more important when coupled with healthcare software systems, embedded software in medical instrumentation, and other healthcare-oriented life-critical systems. The current Food and Drug Administration (FDA) regulatory requirements and guidance documentation do not address certain aspects of complete software assurance activities. In addition, the FDA’s software oversight processes require enhancement to include increasingly complex healthcare systems such as Hospital Information Systems (HIS). The importance of complete software assurance is introduced, current regulatory requirements and guidance discussed, and the necessity for enhancements to the current processes shall be highlighted. PMID:17238324

TWRS configuration management requirement source document

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vann, J.M.

The TWRS Configuration Management (CM) Requirement Source document prescribes CM as a basic product life-cycle function by which work and activities are conducted or accomplished. This document serves as the requirements basis for the TWRS CM program. The objective of the TWRS CM program is to establish consistency among requirements, physical/functional configuration, information, and documentation for TWRS and TWRS products, and to maintain this consistency throughout the life-cycle of TWRS and the product, particularly as changes are being made.

The Algorithm Theoretical Basis Document for Level 1A Processing

NASA Technical Reports Server (NTRS)

Jester, Peggy L.; Hancock, David W., III

2012-01-01

The first process of the Geoscience Laser Altimeter System (GLAS) Science Algorithm Software converts the Level 0 data into the Level 1A Data Products. The Level 1A Data Products are the time ordered instrument data converted from counts to engineering units. This document defines the equations that convert the raw instrument data into engineering units. Required scale factors, bias values, and coefficients are defined in this document. Additionally, required quality assurance and browse products are defined in this document.

Signature detection and matching for document image retrieval.

PubMed

Zhu, Guangyu; Zheng, Yefeng; Doermann, David; Jaeger, Stefan

2009-11-01

As one of the most pervasive methods of individual identification and document authentication, signatures present convincing evidence and provide an important form of indexing for effective document image processing and retrieval in a broad range of applications. However, detection and segmentation of free-form objects such as signatures from clustered background is currently an open document analysis problem. In this paper, we focus on two fundamental problems in signature-based document image retrieval. First, we propose a novel multiscale approach to jointly detecting and segmenting signatures from document images. Rather than focusing on local features that typically have large variations, our approach captures the structural saliency using a signature production model and computes the dynamic curvature of 2D contour fragments over multiple scales. This detection framework is general and computationally tractable. Second, we treat the problem of signature retrieval in the unconstrained setting of translation, scale, and rotation invariant nonrigid shape matching. We propose two novel measures of shape dissimilarity based on anisotropic scaling and registration residual error and present a supervised learning framework for combining complementary shape information from different dissimilarity metrics using LDA. We quantitatively study state-of-the-art shape representations, shape matching algorithms, measures of dissimilarity, and the use of multiple instances as query in document image retrieval. We further demonstrate our matching techniques in offline signature verification. Extensive experiments using large real-world collections of English and Arabic machine-printed and handwritten documents demonstrate the excellent performance of our approaches.

The SeaWiFS Bio-Optical Archive and Storage System (SeaBASS): Current Architecture and Implementation

NASA Technical Reports Server (NTRS)

Werdell, P. Jeremy; Fargion, Giulietta S. (Editor); McClain, Charles R. (Editor); Bailey, Sean W.

2002-01-01

Satellite ocean color missions require an abundance of high-quality in situ measurements for bio-optical and atmospheric algorithm development and post-launch product validation and sensor calibration. To facilitate the assembly of a global data set, the NASA Sea-viewing Wide Field-of-view (SeaWiFS) Project developed the Seafaring Bio-optical Archive and Storage System (SeaBASS), a local repository for in situ data regularly used in their scientific analyses. The system has since been expanded to contain data sets collected by the NASA Sensor Intercalibration and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project, as part of NASA Research Announcements NRA-96-MTPE-04 and NRA-99-OES-99. SeaBASS is a well moderated and documented hive for bio-optical data with a simple, secure mechanism for locating and extracting data based on user inputs. Its holdings are available to the general public with the exception of the most recently collected data sets. Extensive quality assurance protocols, comprehensive data and system documentation, and the continuation of an archive and relational database management system (RDBMS) suitable for bio-optical data all contribute to the continued success of SeaBASS. This document provides an overview of the current operational SeaBASS system.

The role of sensory perception in the development and targeting of tobacco products.

PubMed

Carpenter, Carrie M; Wayne, Geoffrey Ferris; Connolly, Gregory N

2007-01-01

To examine tobacco industry research on smoking-related sensory effects, including differences in sensory perception across smoker groups, and to determine whether this research informed targeted product development and impacted the development of commercial tobacco products. We searched previously secret internal tobacco industry documents available online through document databases housed at Tobacco Documents Online, the British American Tobacco Document Archive and the Legacy Tobacco Documents Library. We identified relevant documents using a snowball sampling method to first search the databases using an initial set of key words and to then establish further search terms. Sensory research is a priority within the tobacco industry directly impacting commercial markets both in the United States and internationally. Sensory factors contribute to smoker satisfaction and product acceptance, and play an important role in controlling puffing behavior. Cigarette manufacturers have capitalized on distinct sensory preferences across gender, age and ethnic groups by tailoring products for specific populations. Regulation of tobacco products is needed to address product changes that are used to reinforce or contribute to tobacco dependence; for instance, the incorporation of additives that target attributes such as smoothness, harshness and aftertaste. Greater understanding of the role of sensory effects on smoking behavior may also help to inform the development of tobacco treatment options that support long-term tobacco abstinence.

40 CFR 80.1153 - What are the product transfer document (PTD) requirements for the RFS program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Standard § 80.1153 What are the product transfer document (PTD) requirements for the RFS program? (a) Any time that a person transfers ownership of renewable fuels subject to this subpart, the transferor must... 40 Protection of Environment 17 2014-07-01 2014-07-01 false What are the product transfer document...

40 CFR 80.1153 - What are the product transfer document (PTD) requirements for the RFS program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Standard § 80.1153 What are the product transfer document (PTD) requirements for the RFS program? (a) Any time that a person transfers ownership of renewable fuels subject to this subpart, the transferor must... 40 Protection of Environment 17 2012-07-01 2012-07-01 false What are the product transfer document...

40 CFR 80.1153 - What are the product transfer document (PTD) requirements for the RFS program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Standard § 80.1153 What are the product transfer document (PTD) requirements for the RFS program? (a) Any time that a person transfers ownership of renewable fuels subject to this subpart, the transferor must... 40 Protection of Environment 17 2013-07-01 2013-07-01 false What are the product transfer document...

40 CFR 80.1153 - What are the product transfer document (PTD) requirements for the RFS program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Standard § 80.1153 What are the product transfer document (PTD) requirements for the RFS program? (a) Any time that a person transfers ownership of renewable fuels subject to this subpart, the transferor must... 40 Protection of Environment 16 2011-07-01 2011-07-01 false What are the product transfer document...

40 CFR 80.1153 - What are the product transfer document (PTD) requirements for the RFS program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Standard § 80.1153 What are the product transfer document (PTD) requirements for the RFS program? (a) Any time that a person transfers ownership of renewable fuels subject to this subpart, the transferor must... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What are the product transfer document...

Current Climate Data Set Documentation Standards: Somewhere between Anagrams and Full Disclosure

NASA Astrophysics Data System (ADS)

Fleig, A. J.

2008-12-01

In the 17th century scientists, concerned with establishing primacy for their discoveries while maintaining control of their intellectual property, often published their results as anagrams. Robert Hooke's initial publication in 1676 of his law of elasticity in the form ceiiinossttuv which he revealed two years later as "Ut tension sic vis" or "of the extension, so the force" is one of the better known examples although Galileo, Newton, and many others used the same approach. Fortunately the idea of open publication in scientific journals subject to peer review as a cornerstone of the scientific method gradually became established and is now the norm. Unfortunately though even peer reviewed publication does not necessarily lead to full disclosure. One example of this occurs in the production, review and distribution of large scale data sets of climate variables. Validation papers describe how the data was made in concept but do not provide adequate documentation of the process. Complete provenance of the resulting data sets including description of the exact input files, processing environment, and actual processing code are not required as part of the production and archival effort. A user of the data may be assured by the publication and peer review that the data is considered to be good and usable for scientific investigation but will not know exactly how the data set was made. The problem with this lack of knowledge may be most apparent when considering questions of climate change. Future measurements of the same geophysical parameter will surely be derived from a different observational system than the one used in creating today's data sets. An obvious task in assessing change between the present and the future data set will be to determine how much of the change is because the parameter changed and how much is because the measurement system changed. This will be hard to do without complete knowledge of how the predecessor data set was made. Automated techniques are being developed that will simplify the creation of much of the provenance information but there are both cultural and infrastructure problems that discourage provision of complete documentation. It is time to reconsider what the standards for production and documentation of data sets should be. There is only a short window before the loss of knowledge about current data sets associated with human mortality becomes irreversible. .

Optimizing the European regulatory framework for sustainable bacteriophage therapy in human medicine.

PubMed

Verbeken, Gilbert; Pirnay, Jean-Paul; De Vos, Daniel; Jennes, Serge; Zizi, Martin; Lavigne, Rob; Casteels, Minne; Huys, Isabelle

2012-06-01

For practitioners at hospitals seeking to use natural (not genetically modified, as appearing in nature) bacteriophages for treatment of antibiotic-resistant bacterial infections (bacteriophage therapy), Europe's current regulatory framework for medicinal products hinders more than it facilitates. Although many experts consider bacteriophage therapy to be a promising complementary (or alternative) treatment to antibiotic therapy, no bacteriophage-specific framework for documentation exists to date. Decades worth of historical clinical data on bacteriophage therapy (from Eastern Europe, particularly Poland, and the former Soviet republics, particularly Georgia and Russia, as well as from today's 27 EU member states and the US) have not been taken into account by European regulators because these data have not been validated under current Western regulatory standards. Consequently, applicants carrying out standard clinical trials on bacteriophages in Europe are obliged to initiate clinical work from scratch. This paper argues for a reduced documentation threshold for Phase 1 clinical trials of bacteriophages and maintains that bacteriophages should not be categorized as classical medicinal products for at least two reasons: (1) such a categorization is scientifically inappropriate for this specific therapy and (2) such a categorization limits the marketing authorization process to industry, the only stakeholder with sufficient financial resources to prepare a complete dossier for the competent authorities. This paper reflects on the current regulatory framework for medicines in Europe and assesses possible regulatory pathways for the (re-)introduction of bacteriophage therapy in a way that maintains its effectiveness and safety as well as its inherent characteristics of sustainability and in situ self-amplification and limitation.

The TMIS life-cycle process document, revision A

NASA Technical Reports Server (NTRS)

1991-01-01

The Technical and Management Information System (TMIS) Life-Cycle Process Document describes the processes that shall be followed in the definition, design, development, test, deployment, and operation of all TMIS products and data base applications. This document is a roll out of TMIS Standards Document (SSP 30546). The purpose of this document is to define the life cycle methodology that the developers of all products and data base applications and any subsequent modifications shall follow. Included in this methodology are descriptions of the tasks, deliverables, reviews, and approvals that are required before a product or data base application is accepted in the TMIS environment.

Prevalence and Disparities in Tobacco Product Use Among American Indians/Alaska Natives - United States, 2010-2015.

PubMed

Odani, Satomi; Armour, Brian S; Graffunder, Corinne M; Garrett, Bridgette E; Agaku, Israel T

2017-12-22

An overarching goal of Healthy People 2020 is to achieve health equity, eliminate disparities, and improve health among all groups.* Although significant progress has been made in reducing overall commercial tobacco product use, † disparities persist, with American Indians or Alaska Natives (AI/ANs) having one of the highest prevalences of cigarette smoking among all racial/ethnic groups (1,2). Variations in cigarette smoking among AI/ANs have been documented by sex and geographic location (3), but not by other sociodemographic characteristics. Furthermore, few data exist on use of tobacco products other than cigarettes among AI/ANs (4). CDC analyzed self-reported current (past 30-day) use of five tobacco product types among AI/AN adults from the 2010-2015 National Survey on Drug Use and Health (NSDUH); results were compared with six other racial/ethnic groups (Hispanic; non-Hispanic white [white]; non-Hispanic black [black]; non-Hispanic Native Hawaiian or other Pacific Islander [NHOPI]; non-Hispanic Asian [Asian]; and non-Hispanic multirace [multirace]). Prevalence of current tobacco product use was significantly higher among AI/ANs than among non-AI/ANs combined for any tobacco product, cigarettes, roll-your-own tobacco, pipes, and smokeless tobacco. Among AI/ANs, prevalence of current use of any tobacco product was higher among males, persons aged 18-25 years, those with less than a high school diploma, those with annual family income <$20,000, those who lived below the federal poverty level, and those who were never married. Addressing the social determinants of health and providing evidence-based, population-level, and culturally appropriate tobacco control interventions could help reduce tobacco product use and eliminate disparities in tobacco product use among AI/ANs (1).

Tactical Approaches for Making a Successful Satellite Passive Microwave ESDR

NASA Astrophysics Data System (ADS)

Hardman, M.; Brodzik, M. J.; Gotberg, J.; Long, D. G.; Paget, A. C.

2014-12-01

Our NASA MEaSUREs project is producing a new, enhanced resolution gridded Earth System Data Record for the entire satellite passive microwave (SMMR, SSM/I-SSMIS and AMSR-E) time series. Our project goals are twofold: to produce a well-documented, consistently processed, high-quality historical record at higher spatial resolutions than have previously been available, and to transition the production software to the NSIDC DAAC for ongoing processing after our project completion. In support of these goals, our distributed team at BYU and NSIDC faces project coordination challenges to produce a high-quality data set that our user community will accept as a replacement for the currently available historical versions of these data. We work closely with our DAAC liaison on format specifications, data and metadata plans, and project progress. In order for the user community to understand and support our project, we have solicited a team of Early Adopters who are reviewing and evaluating a prototype version of the data. Early Adopter feedback will be critical input to our final data content and format decisions. For algorithm transparency and accountability, we have released an Algorithm Theoretical Basis Document (ATBD) and detailed supporting technical documentation, with rationale for all algorithm implementation decisions. For distributed team management, we are using collaborative tools for software revision control and issue tracking. For reliably transitioning a research-quality image reconstruction software system to production-quality software suitable for use at the DAAC, we have adopted continuous integration methods for running automated regression testing. Our presentation will summarize bothadvantages and challenges of each of these tactics in ensuring production of a successful ESDR and an enduring production software system.

AgRISTARS: Foreign Commodity production forecasting. Project procedures designation and description document, volume 1

NASA Technical Reports Server (NTRS)

Waggoner, J. T.; Phinney, D. E. (Principal Investigator)

1981-01-01

The crop estimation analysis procedures documentation of the AgRISTARS - Foreign Commodity Production Forecasting Project (FCPF) is presented. Specifically it includes the technical/management documentation of the remote sensing data analysis procedures prepared in accordance with the guidelines provided in the FCPF communication/documentation standards manual. Standard documentation sets are given arranged by procedural type and level then by crop types or other technically differentiating categories.

14 CFR 1216.319 - Environmental resources document.

Code of Federal Regulations, 2010 CFR

2010-01-01

... environmental resources document which describes the current environment at that field installation, including current information on the effects of NASA operations on the local environment. This document shall include information on the same environmental effects as included in an environmental impact statement...

14 CFR 1216.319 - Environmental resources document.

Code of Federal Regulations, 2011 CFR

2011-01-01

... environmental resources document which describes the current environment at that field installation, including current information on the effects of NASA operations on the local environment. This document shall include information on the same environmental effects as included in an environmental impact statement...

Critical Review of NOAA's Observation Requirements Process

NASA Astrophysics Data System (ADS)

LaJoie, M.; Yapur, M.; Vo, T.; Templeton, A.; Bludis, D.

2017-12-01

NOAA's Observing Systems Council (NOSC) maintains a comprehensive database of user observation requirements. The requirements collection process engages NOAA subject matter experts to document and effectively communicate the specific environmental observation measurements (parameters and attributes) needed to produce operational products and pursue research objectives. User observation requirements documented using a structured and standardized manner and framework enables NOAA to assess its needs across organizational lines in an impartial, objective, and transparent manner. This structure provides the foundation for: selecting, designing, developing, acquiring observing technologies, systems and architectures; budget and contract formulation and decision-making; and assessing in a repeatable fashion the productivity, efficiency and optimization of NOAA's observing system enterprise. User observation requirements are captured independently from observing technologies. Therefore, they can be addressed by a variety of current or expected observing capabilities and allow flexibility to be remapped to new and evolving technologies. NOAA's current inventory of user observation requirements were collected over a ten-year period, and there have been many changes in policies, mission priorities, and funding levels during this time. In light of these changes, the NOSC initiated a critical, in-depth review to examine all aspects of user observation requirements and associated processes during 2017. This presentation provides background on the NOAA requirements process, major milestones and outcomes of the critical review, and plans for evolving and connecting observing requirements processes in the next year.

40 CFR 80.1453 - What are the product transfer document (PTD) requirements for the RFS program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... blend pursuant to § 80.1429(b)(4), then all PTDs which are at any time used to transfer ownership of the... 40 Protection of Environment 17 2012-07-01 2012-07-01 false What are the product transfer document... Standard § 80.1453 What are the product transfer document (PTD) requirements for the RFS program? (a) On...

Marketing to America's youth: evidence from corporate documents.

PubMed

Cummings, K M; Morley, C P; Horan, J K; Steger, C; Leavell, N-R

2002-03-01

To evaluate the claim that the tobacco industry does not market its products to youth. The data for this study come from tobacco industry documents collected from the tobacco industry's document websites, presently linked at http://www.tobaccoarchives.com. The websites were searched using "request for production" (RFP) codes, specified keyword searches, and serendipitous terms identified in document citations found with RFP and keyword searches. Industry documents show that the cigarette manufacturers carefully monitored the smoking habits of teenagers over the past several decades. Candid quotes from industry executives refer to youth as a source of sales and as fundamental to the survival of the tobacco industry. The documents reveal that the features of cigarette brands (that is, use of filters, low tar, bland taste, etc), packaging (that is, size, colour and design), and advertising (that is, media placements and themes and imagery) were developed specifically to appeal to new smokers (that is, teenagers). Evidence also indicates that relevant youth oriented marketing documents may have been destroyed and that the language used in some of the more recent documents may have been sanitised to cover up efforts to market to youth. The tobacco industry's internal documents reveal an undeniable interest in marketing cigarettes to underage smokers. The industry's marketing approaches run counter to and predicate methods for tobacco prevention: (1) keep the price of the product high; (2) keep product placements and advertising away from schools and other areas with a high volume of youth traffic; (3) make cigarette advertising (that is, themes and visual images) unappealing to youth; (4) make product packaging unappealing to youth; and (5) design the product so it is not easy to inhale.

Electronic cigarettes: product characterisation and design considerations.

PubMed

Brown, Christopher J; Cheng, James M

2014-05-01

To review the available evidence regarding electronic cigarette (e-cigarette) product characterisation and design features in order to understand their potential impact on individual users and on public health. Systematic literature searches in 10 reference databases were conducted through October 2013. A total of 14 articles and documents and 16 patents were included in this analysis. Numerous disposable and reusable e-cigarette product options exist, representing wide variation in product configuration and component functionality. Common e-cigarette components include an aerosol generator, a flow sensor, a battery and a nicotine-containing solution storage area. e-cigarettes currently include many interchangeable parts, enabling users to modify the character of the delivered aerosol and, therefore, the product's 'effectiveness' as a nicotine delivery product. Materials in e-cigarettes may include metals, rubber and ceramics. Some materials may be aerosolised and have adverse health effects. Several studies have described significant performance variability across and within e-cigarette brands. Patent applications include novel product features designed to influence aerosol properties and e-cigarette efficiency at delivering nicotine. Although e-cigarettes share a basic design, engineering variations and user modifications result in differences in nicotine delivery and potential product risks. e-cigarette aerosols may include harmful and potentially harmful constituents. Battery explosions and the risks of exposure to the e-liquid (especially for children) are also concerns. Additional research will enhance the current understanding of basic e-cigarette design and operation, aerosol production and processing, and functionality. A standardised e-cigarette testing regime should be developed to allow product comparisons.

76 FR 35619 - Labeling and Effectiveness Testing; Sunscreen Drug Products for Over-the-Counter Human Use

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

...The Food and Drug Administration (FDA) is issuing this document to address labeling and effectiveness testing for certain over-the counter (OTC) sunscreen products containing specified active ingredients and marketed without approved applications. This document addresses labeling and effectiveness testing issues raised by the nearly 2,900 submissions that we received in response to the sunscreen proposed rule of August 27, 2007 (2007 proposed rule). The document also identifies specific claims that render a product that is subject to this rule misbranded or would not be allowed on any OTC sunscreen product marketed without an approved application. The document does not address issues related to sunscreen active ingredients or certain other issues regarding the GRASE determination for sunscreen products. The document requires OTC sunscreen products to comply with the content and format requirements for OTC drug labeling contained in the 1999 Drug Facts final rule (published in the Federal Register of March 17, 1999, by lifting the delay of implementation date for that rule that we published on September 3, 2004).

Publication Production: An Annotated Bibliography.

ERIC Educational Resources Information Center

Firman, Anthony H.

1994-01-01

Offers brief annotations of 52 articles and papers on document production (from the Society for Technical Communication's journal and proceedings) on 9 topics: information processing, document design, using color, typography, tables, illustrations, photography, printing and binding, and production management. (SR)

78 FR 68849 - Draft Current Intelligence Bulletin “Update of NIOSH Carcinogen Classification and Target Risk...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-15

...; Docket Number NIOSH 240-A] Draft Current Intelligence Bulletin ``Update of NIOSH Carcinogen... document for public comment entitled ``Current Intelligence Bulletin: Update of NIOSH Carcinogen... obtain comments on the draft document, ``Current Intelligence Bulletin: Update of NIOSH Carcinogen...

Tobacco Industry Consumer Research on Smokeless Tobacco Users and Product Development

PubMed Central

Mejia, Adrienne B.

2010-01-01

Since 2006, RJ Reynolds (RJR) and Philip Morris have both introduced new smokeless “snus” tobacco products. We analyzed previously secret tobacco industry documents describing the history of RJR and Philip Morris's consumer research, smokeless product development, and marketing strategies. We found that RJR had invested in smokeless research, development, and marketing since 1968. RJR first targeted low-income males through sampling and sponsorship at fishing, rodeo, and baseball events, and through advertising portraying the user as “hard working.” In the early 1990s, Philip Morris and RJR hoped to attract more urban, female smokeless users. The current “snus” campaigns appear to appeal to these targeted consumers and smokers in smoke-free environments. These efforts may expand the tobacco market and undermine smoking cessation. PMID:19910355

27 CFR 41.193 - Corporate documents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Corporate documents. 41..., AND PROCESSED TOBACCO Tobacco Products Importers § 41.193 Corporate documents. Every corporation... permit, required by § 41.191, a true copy of the corporate charter or a certificate of corporate...

37 CFR 205.22 - Production of documents and testimony.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Production of documents and testimony. 205.22 Section 205.22 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... fees associated with various document requests, searches, copies, and expedited handling are listed in...

37 CFR 205.22 - Production of documents and testimony.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Production of documents and testimony. 205.22 Section 205.22 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... fees associated with various document requests, searches, copies, and expedited handling are listed in...

37 CFR 205.22 - Production of documents and testimony.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Production of documents and testimony. 205.22 Section 205.22 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... fees associated with various document requests, searches, copies, and expedited handling are listed in...

27 CFR 25.66 - Organizational documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Organizational documents. The supporting information required by paragraph (a)(4) of § 25.62 includes, as... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Organizational documents. 25.66 Section 25.66 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU...

27 CFR 19.167 - Organizational documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

....167 Organizational documents. The supporting information required by paragraph (c) of § 19.152, and... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Organizational documents. 19.167 Section 19.167 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU...

27 CFR 19.916 - Organizational documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Organizational documents. The supporting information required by paragraph (a)(5) of § 19.915, includes, as... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Organizational documents. 19.916 Section 19.916 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU...

27 CFR 18.25 - Organizational documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... § 18.25 Organizational documents. The supporting information required by paragraph (d) of § 18.24... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Organizational documents. 18.25 Section 18.25 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU...

27 CFR 20.45 - Organizational documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... and Users Application for Permit, Form 5150.22 § 20.45 Organizational documents. The supporting... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Organizational documents. 20.45 Section 20.45 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU...

Sustainable improvement of animal health care by systematic quality risk management according to the HACCP concept.

PubMed

Noordhuizen, J P; Welpelo, H J

1996-12-01

This paper addresses the principles of the Hazard Analysis Critical Control Point (HACCP) concept as applied to animal health management strategy. Characteristics of the concept were analysed and compared with those of current animal health care strategies for disease risk identification and herd health management, insurance, and certification. HACCP is a hybrid strategy of quality control at both production process and product level. Animal health is considered a particular quality feature. We show that process control (expressed in terms of controlling both general and specific disease risk factors) and product control (expressed in terms of testing animals or animal products for specific disease agents) could form the basis for improving animal health. We conclude that HACCP provides ample opportunity for preventive health action and risk management at a relatively low cost in terms of labour, finance and documentation expenditure, at both the farm and sector level. Epidemiological field studies are currently needed to identify critical control points and to design HACCP procedures for livestock producers. In the long run, HACCP based animal health care can be further developed into a quality control systems approach to cover all aspects that are related, either directly or indirectly, to animal health.

Marketing to America's youth: evidence from corporate documents

PubMed Central

Cummings, K; Morley, C; Horan, J; Steger, C; Leavell, N

2002-01-01

Design: The data for this study come from tobacco industry documents collected from the tobacco industry's document websites, presently linked at http://www.tobaccoarchives.com. The websites were searched using "request for production" (RFP) codes, specified keyword searches, and serendipitous terms identified in document citations found with RFP and keyword searches. Results: Industry documents show that the cigarette manufacturers carefully monitored the smoking habits of teenagers over the past several decades. Candid quotes from industry executives refer to youth as a source of sales and as fundamental to the survival of the tobacco industry. The documents reveal that the features of cigarette brands (that is, use of filters, low tar, bland taste, etc), packaging (that is, size, colour and design), and advertising (that is, media placements and themes and imagery) were developed specifically to appeal to new smokers (that is, teenagers). Evidence also indicates that relevant youth oriented marketing documents may have been destroyed and that the language used in some of the more recent documents may have been sanitised to cover up efforts to market to youth. Conclusions: The tobacco industry's internal documents reveal an undeniable interest in marketing cigarettes to underage smokers. The industry's marketing approaches run counter to and predicate methods for tobacco prevention: (1) keep the price of the product high; (2) keep product placements and advertising away from schools and other areas with a high volume of youth traffic; (3) make cigarette advertising (that is, themes and visual images) unappealing to youth; (4) make product packaging unappealing to youth; and (5) design the product so it is not easy to inhale. PMID:11893810

Operations Nomenclature [Annexes

NASA Technical Reports Server (NTRS)

Shannon, Yvette Y.

2011-01-01

The purpose of Operations Nomenclature (OpNom) is to document methods for denoting all hardware and software and associated data referenced by operations products produced by the International Space Station (ISS) operations community. This includes Operations Data File (ODF) procedures, ground and onboard displays, mission rules, commands, messages and advisories, planning products, etc. This document applies to all agencies and individuals participating in or contributing to ISS mission operations. Mission operations include ground checkout, training, and simulations, as well as real-time activities. The document also applies to all operations documentation (paper or electronic media) and other products that refer to ISS-related equipment or activities.

Food allergen extracts to diagnose food-induced allergic diseases: How they are made.

PubMed

David, Natalie A; Penumarti, Anusha; Burks, A Wesley; Slater, Jay E

2017-08-01

To review the manufacturing procedures of food allergen extracts and applicable regulatory requirements from government agencies, potential approaches to standardization, and clinical application of these products. The effects of thermal processing on allergenicity of common food allergens are also considered. A broad literature review was conducted on the natural history of food allergy, the manufacture of allergen extracts, and the allergenicity of heated food. Regulations, guidance documents, and pharmacopoeias related to food allergen extracts from the United States and Europe were also reviewed. Authoritative and peer-reviewed research articles relevant to the topic were chosen for review. Selected regulations and guidance documents are current and relevant to food allergen extracts. Preparation of a food allergen extract may require careful selection and identification of source materials, grinding, defatting, extraction, clarification, sterilization, and product testing. Although extractions for all products licensed in the United States are performed using raw source materials, many foods are not consumed in their raw form. Heating foods may change their allergenicity, and doing so before extraction may change their allergenicity and the composition of the final product. The manufacture of food allergen extracts requires many considerations to achieve the maximal quality of the final product. Allergen extracts for a select number of foods may be inconsistent between manufacturers or unreliable in a clinical setting, indicating a potential area for future improvement. Copyright © 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

77 FR 69870 - Federal Housing Administration (FHA) Healthcare Facility Documents: Revisions and Updates and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-21

... updating and revising a set of production, underwriting, asset management, closing, and other documents... clarify the requirements for a management agent and the management agreement. Production--Firm Commitments... closing documents to the Office of Management and Budget (OMB) for review and approval, and assignment of...

Student Outcomes 2009: Data Dictionary. Support Document

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2009

2009-01-01

This document was produced as an added resource for the report "Outcomes from the Productivity Places Program, 2009." The study reported the outcomes for students who completed their vocational education and training (VET) under the Productivity Places Program (PPP) during 2008. This document presents an alphabetical arrangement of the…

27 CFR 41.193 - Corporate documents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Corporate documents. 41..., AND PROCESSED TOBACCO Tobacco Products Importers § 41.193 Corporate documents. Every corporation that... for the permit required by § 41.191 a true copy of the corporate charter or a certificate of corporate...

27 CFR 41.193 - Corporate documents.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Corporate documents. 41.193... PROCESSED TOBACCO Tobacco Products Importers § 41.193 Corporate documents. Every corporation, before..., required by § 41.191, a true copy of the corporate charter or a certificate of corporate existence or...

27 CFR 19.677 - Large plant applications-organizational documents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Large plant applications-organizational documents. 19.677 Section 19.677 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... Fuel Use Obtaining A Permit § 19.677 Large plant applications—organizational documents. In addition to...

22 CFR 401.22 - Attendance of witnesses and production of documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... documents. 401.22 Section 401.22 Foreign Relations INTERNATIONAL JOINT COMMISSION, UNITED STATES AND CANADA RULES OF PROCEDURE Applications § 401.22 Attendance of witnesses and production of documents. (a... authorized by the Chairman of that section. (b) All applications for subpoena or other process to compel the...

37 CFR 205.22 - Production of documents and testimony.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Production of documents and testimony. 205.22 Section 205.22 Patents, Trademarks, and Copyrights U.S. COPYRIGHT OFFICE, LIBRARY OF... fees associated with various document requests, searches, copies, and expedited handling are listed in...

27 CFR 22.45 - Organizational documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Permit, Form 5150.22 § 22.45 Organizational documents. The supporting information required by § 22.42(a... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Organizational documents. 22.45 Section 22.45 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU...

Modeling and Depletion Simulations for a High Flux Isotope Reactor Cycle with a Representative Experiment Loading

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chandler, David; Betzler, Ben; Hirtz, Gregory John

2016-09-01

The purpose of this report is to document a high-fidelity VESTA/MCNP High Flux Isotope Reactor (HFIR) core model that features a new, representative experiment loading. This model, which represents the current, high-enriched uranium fuel core, will serve as a reference for low-enriched uranium conversion studies, safety-basis calculations, and other research activities. A new experiment loading model was developed to better represent current, typical experiment loadings, in comparison to the experiment loading included in the model for Cycle 400 (operated in 2004). The new experiment loading model for the flux trap target region includes full length 252Cf production targets, 75Se productionmore » capsules, 63Ni production capsules, a 188W production capsule, and various materials irradiation targets. Fully loaded 238Pu production targets are modeled in eleven vertical experiment facilities located in the beryllium reflector. Other changes compared to the Cycle 400 model are the high-fidelity modeling of the fuel element side plates and the material composition of the control elements. Results obtained from the depletion simulations with the new model are presented, with a focus on time-dependent isotopic composition of irradiated fuel and single cycle isotope production metrics.« less

The SeaFlux Turbulent Flux Dataset Version 1.0 Documentation

NASA Technical Reports Server (NTRS)

Clayson, Carol Anne; Roberts, J. Brent; Bogdanoff, Alec S.

2012-01-01

Under the auspices of the World Climate Research Programme (WCRP) Global Energy and Water cycle EXperiment (GEWEX) Data and Assessment Panel (GDAP), the SeaFlux Project was created to investigate producing a high-resolution satellite-based dataset of surface turbulent fluxes over the global oceans. The most current release of the SeaFlux product is Version 1.0; this represents the initial release of turbulent surface heat fluxes, associated near-surface variables including a diurnally varying sea surface temperature.

Destruction and Vitrification of Asbestos Using Plasma Arc Technology (Construction Productivity Advancement Research (CPAR) Program)

DTIC Science & Technology

1993-09-01

DOCUMENTATION PAGE M N Public mpsMIs b~ b•r tOr coleton of ia nlormmn ias edsimad to aevue 1 hour pw response , indudng the Snm ta raing e. taeu"tig aining...Asbestos Emergency Response Act of 1986 (AHERA), which mandates inspection in school grades Kindergarten through 12. Congress is currently...CRC), Georgia Institute of Technology, Atlanta, GA. The CRC was responsible for the technical portion of the research program; i.e., developing the test

[Predacious nematode-destroying fungi].

PubMed

Czygier, M; Boguś, M I

2001-01-01

Gastrointestinal nematodes are considered a serious economic problem affecting the livestock industry around the world. Current methods of their control, relaying mainly on organic drugs, are not sustainable because parasites develop resistance to anthelmintic and bacause of increasing public concern about chemicals residues in livestock products and environment. Nematode-trapping fungi offer a very promissing, nonchemotherapeutic approach to nematode parasite control. Their potential in preventing nematodosis is well documented. In this paper we outline the present knowlege on mechanisms involved in trapping and killing nematodes by the predacious nematode-destroying fungi.

Tactical Tomahawk RGM-109E/UGM-109E Missile (TACTOM)

DTIC Science & Technology

2015-12-01

2004: Operational Requirements Document for Tomahawk Weapons Systems Baseline IV signed. TACTOM is authorized in Chapter 2 of this system level ...5124.8 3290.3 6885.4 6390.4 1 APB Breach Confidence Level Confidence Level of cost estimate for current APB: 51% The estimate to support this program...Development Estimate Changes PAUC Production Estimate Econ Qty Sch Eng Est Oth Spt Total 1.365 -0.015 0.324 0.117 0.000 -0.716 0.000 0.104 -0.186 1.179

Rapid Aluminum Nanoparticle Production by Milling in NH3 and CH3NH2 Atmospheres: An Experimental and Theoretical Study

DTIC Science & Technology

2015-07-01

REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information is estimated to average 1...currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 1 July 2015 2. REPORT TYPE...ABSTRACT Unclassified c. THIS PAGE Unclassified SAR 105 19b. TELEPHONE NO (include area code) N/A Standard Form 298 (Rev. 8-98

A historical review of additives and modifiers used in paving asphalt refining processes in the United States.

PubMed

Mundt, Diane J; Adams, Robert C; Marano, Kristin M

2009-11-01

The U.S. asphalt paving industry has evolved over time to meet various performance specifications for liquid petroleum asphalt binder (known as bitumen outside the United States). Additives to liquid petroleum asphalt produced in the refinery may affect exposures to workers in the hot mix paving industry. This investigation documented the changes in the composition and distribution of the liquid petroleum asphalt products produced from petroleum refining in the United States since World War II. This assessment was accomplished by reviewing documents and interviewing individual experts in the industry to identify current and historical practices. Individuals from 18 facilities were surveyed; the number of facilities reporting use of any material within a particular class ranged from none to more than half the respondents. Materials such as products of the process stream, polymers, elastomers, and anti-strip compounds have been added to liquid petroleum asphalt in the United States over the past 50 years, but modification has not been generally consistent by geography or time. Modifications made to liquid petroleum asphalt were made generally to improve performance and were dictated by state specifications.

Making the Implicit Explicit: Towards an Assurance Case for DO-178C

NASA Technical Reports Server (NTRS)

Holloway, C. Michael

2013-01-01

For about two decades, compliance with Software Considerations in Airborne Systems and Equipment Certification (DO-178B) has been the primary means for receiving regulatory approval for using software on commercial airplanes. A new edition of the standard, DO-178C, was published in December 2011, and regulatory bodies have started the process towards recognizing this edition. The stated purpose of DO-178C remains unchanged from its predecessor: providing guidance “for the production of software for airborne systems and equipment that performs its intended function with a level of confidence in safety that complies with airworthiness requirements.” Within the text of the guidance, little or no rationale is given for how a particular objective or collection of objectives contributes to achieving this purpose. Thus the assurance case for the document is implicit. This paper discusses a current effort to make the implicit explicit. In particular, the paper describes the current status of the research seeking to identify the specific arguments contained in, or implied by, the DO-178C guidance that implicitly justify the assumption that the document meets its stated purpose.

A Document Analysis of Teacher Evaluation Systems Specific to Physical Education

ERIC Educational Resources Information Center

Norris, Jason M.; van der Mars, Hans; Kulinna, Pamela; Kwon, Jayoun; Amrein-Beardsley, Audrey

2017-01-01

Purpose: The purpose of this document analysis study was to examine current teacher evaluation systems, understand current practices, and determine whether the instrumentation is a valid measure of teaching quality as reflected in teacher behavior and effectiveness specific to physical education (PE). Method: An interpretive document analysis…

Cigarette Users’ Interest in Using or Switching to Electronic Nicotine Delivery Systems for Smokeless Tobacco for Harm Reduction, Cessation, or Novelty: A Cross-Sectional Survey of US Adults

PubMed Central

Haardoerfer, Regine; Escoffery, Cam; Zheng, Pinpin; Kegler, Michelle

2015-01-01

Introduction: We examined: (a) current (past 30-day) smokers’ interest in using or switching to electronic nicotine delivery systems (ENDS) or smokeless tobacco for various reasons; (b) correlates of interest in these products; and (c) subgroups of current smokers in relation to interest in these products. Methods: We conducted a cross-sectional survey assessing sociodemographics, tobacco use, interest in ENDS and smokeless tobacco among smokers, and knowledge about ENDS among 2,501US adults recruited through an online consumer panel. We oversampled tobacco users (36.7% current cigarette smokers), ethnic minorities, and southeastern US state residents. Results: On average, participants were more interested in ENDS than smokeless tobacco across all reasons provided. Additionally, they were less interested in either product because of their potential use in places prohibiting smoking or due to curiosity and more interested in reducing health risk or cigarette consumption or to aid in cessation. We documented high rates (27.9%) of misbeliefs about Food and Drug Administration approval of ENDS for cessation, particularly among current smokers (38.5%). Also, 27.2% of current smokers had talked with a health care provider about ENDS, with 18.0% reporting that their provider endorsed ENDS use for cessation. Furthermore, cluster analyses revealed 3 groups distinct in their interest in the products, sociodemographics, and smoking-related characteristics. Conclusions: This study highlights higher interest in ENDS versus smokeless tobacco and greater interest in both for harm reduction and cessation than due to novelty or smoking restrictions. Developing educational campaigns and informing practitioners about caveats around ENDS as cessation or harm reduction aids are critical. PMID:24951496

The Fifth Calibration/Data Product Validation Panel Meeting

NASA Technical Reports Server (NTRS)

1992-01-01

The minutes and associated documents prepared from presentations and meetings at the Fifth Calibration/Data Product Validation Panel meeting in Boulder, Colorado, April 8 - 10, 1992, are presented. Key issues include (1) statistical characterization of data sets: finding statistics that characterize key attributes of the data sets, and defining ways to characterize the comparisons among data sets; (2) selection of specific intercomparison exercises: selecting characteristic spatial and temporal regions for intercomparisons, and impact of validation exercises on the logistics of current and planned field campaigns and model runs; and (3) preparation of data sets for intercomparisons: characterization of assumptions, transportable data formats, labeling data files, content of data sets, and data storage and distribution (EOSDIS interface).

Experiences with Extra-Vehicular Activities in Response to Critical ISS Contingencies

NASA Technical Reports Server (NTRS)

Van Cise, Edward A.; Kelly, Brian J.; Radigan, Jeffery P.; Cranmer, Curtis W.

2016-01-01

Initial "Big 14" work was put to the test for the first time in 2010. Deficiencies were found in some of the planning and approaches to that work; Failure Response Assessment Team created in 2010 to address deficiencies -Identify and perform engineering analysis in operations products prior to failure; incorporate results into operations products -Identify actions for protecting ISS against a Next Worse Failure after the first failure occurs -Better document not only EVA products but also planning products, assumptions, and open actions; Pre-failure investments against critical failures best postures ISS for swift response and recovery -A type of insurance policy -Has proven effective in a number of contingency EVA cases since 2010. Planning for MBSU R&R in 2012, Second PM R&R in 2013, EXT MDM R&R in 2014; Current FRAT schedule projects completion of all analysis in 2018

Time--temperature indicator for perishable products based on kinetically programmable Ag overgrowth on Au nanorods.

PubMed

Zhang, Chao; Yin, An-Xiang; Jiang, Ruibin; Rong, Jie; Dong, Lu; Zhao, Tian; Sun, Ling-Dong; Wang, Jianfang; Chen, Xing; Yan, Chun-Hua

2013-05-28

Food safety is a constant concern for humans. Besides adulteration and contamination, another major threat comes from the spontaneous spoilage of perishable products, which is basically inevitable and highly dependent on the temperature history during the custody chain. For advanced quality control and assessment, time-temperature indicators (TTIs) can be deployed to document the temperature history. However, the use of TTIs is currently limited by either relatively high cost or poor programmability. Here we describe a general, kinetically programmable, and cost-efficient TTI protocol constructed from plasmonic nanocrystals. We present proof-of-principle demonstrations that our TTI can be specifically tailored and thus used to track perishables, dynamically mimic the deteriorative processes therein, and indicate product quality through sharp-contrast multicolor changes. The flexible programmability of our TTI, combined with its substantially low cost and low toxicity, promises a general applicability to each single packaged item of a plethora of perishable products.

Information system life-cycle and documentation standards, volume 1

NASA Technical Reports Server (NTRS)

Callender, E. David; Steinbacher, Jody

1989-01-01

The Software Management and Assurance Program (SMAP) Information System Life-Cycle and Documentation Standards Document describes the Version 4 standard information system life-cycle in terms of processes, products, and reviews. The description of the products includes detailed documentation standards. The standards in this document set can be applied to the life-cycle, i.e., to each phase in the system's development, and to the documentation of all NASA information systems. This provides consistency across the agency as well as visibility into the completeness of the information recorded. An information system is software-intensive, but consists of any combination of software, hardware, and operational procedures required to process, store, or transmit data. This document defines a standard life-cycle model and content for associated documentation.

Global tissue engineering trends. A scientometric and evolutive study.

PubMed

Santisteban-Espejo, Antonio; Campos, Fernando; Martin-Piedra, Laura; Durand-Herrera, Daniel; Moral-Munoz, Jose A; Campos, Antonio; Martin-Piedra, Miguel Angel

2018-04-24

Tissue engineering is defined as a multidisciplinary scientific discipline with the main objective to develop artificial bioengineered living tissues in order to regenerate damaged or lost tissues. Since its appearance in 1988, tissue engineering has globally spreaded in order to improve current therapeutical approaches, entailing a revolution in clinical practice. The aim of this study is to analyze global research trends on tissue engineering publications in order to realize the scenario of tissue engineering research from 1991 to 2016 by using document retrieval from Web of Science database and bibliometric analysis. Document type, language, source title, authorship, countries and filiation centers and citation count were evaluated in 31,859 documents. Obtained results suggest a great multidisciplinary role of tissue engineering due to a wide spectrum -up to 51- of scientific research areas identified in the corpus of literature, being predominant technological disciplines as Material Sciences or Engineering, followed by biological and biomedical areas, as Cell Biology, Biotechnology or Biochemistry. Distribution of authorship, journals and countries revealed a clear imbalance in which a minority is responsible of a majority of documents. Such imbalance is notorious in authorship, where a 0.3% of authors are involved in the half of the whole production.

Role of standard documents in advancing the standardization of microfluidics connectors

NASA Astrophysics Data System (ADS)

Tantra, Ratna; van Heeren, Henne; Jarman, John

2016-04-01

An emerging trend within the microfluidic community is to standardize common parts in order to facilitate design and production activities. The goal is clear: to enhance interoperability and promote plug-and-play. A recent launch of a pan-European project, Microfluidic (MF) Manufacturing, has identified an item that is in immediate need of standardization: having in place geometrical specifications for MF connectors. In order to accelerate the adoption of such standards, there is a need to consider the pivotal role of standard documents. The purpose of this paper is to provide background information on document standards development. In addition, the future implications related to the MF manufacturing project will be discussed. A strengths, weaknesses, opportunities, and threats analysis has been carried out to identify points of action. The findings show that although there is a need to publish under International Organization for Standardization (ISO), the actual realization of a full ISO standard document is not feasible. The recommendation is to initially publish via an ISO Workshop Agreement. Parallel to such activity, there is a need to encourage stakeholders help kick start a currently dormant working group that supports microfluidics under ISO to help pave the way for future standardization activities in the microfluidics community.

Rolling Deck to Repository (R2R): Products and Services for the U.S. Research Fleet Community

NASA Astrophysics Data System (ADS)

Arko, R. A.; Carbotte, S. M.; Chandler, C. L.; Smith, S. R.; Stocks, K. I.

2016-02-01

The Rolling Deck to Repository (R2R) program is working to ensure open access to environmental sensor data routinely acquired by the U.S. academic research fleet. Currently 25 vessels deliver 7 TB/year of data to R2R from a suite of geophysical, oceanographic, meteorological, and navigational sensors on over 400 cruises worldwide. R2R ensures these data are preserved in trusted repositories, discoverable via standard protocols, and adequately documented for reuse. R2R has recently expanded to include the vessels Sikuliaq, operated by the University of Alaska; Falkor, operated by the Schmidt Ocean Institute; and Ronald H. Brown and Okeanos Explorer, operated by NOAA. R2R maintains a master catalog of U.S. research cruises, currently holding over 4,670 expeditions including vessel and cruise identifiers, start/end dates and ports, project titles and funding awards, science parties, dataset inventories with instrument types and file formats, data quality assessments, and links to related content at other repositories. Standard post-field cruise products are published including shiptrack navigation, near-real-time MET/TSG data, underway geophysical profiles, and CTD profiles. Software tools available to users include the R2R Event Logger and the R2R Nav Manager. A Digital Object Identifier (DOI) is published for each cruise, original field sensor dataset, standard post-field product, and document (e.g. cruise report) submitted by the science party. Scientists are linked to personal identifiers such as ORCIDs where available. Using standard identifiers such as DOIs and ORCIDs facilitates linking with journal publications and generation of citation metrics. R2R collaborates in the Ocean Data Interoperability Platform (ODIP) to strengthen links among regional and national data systems, populates U.S. cruises in the POGO global catalog, and is working toward membership in the DataONE alliance. It is a lead partner in the EarthCube GeoLink project, developing Semantic Web technologies to share data and documentation between repositories, and in the newly-launched EarthCube SeaView project, delivering data from R2R and other ocean data facilities to scientists using the Ocean Data View (ODV) software tool.

Life-Cycle Inventory Analysis of I-joist Production in the United States

Treesearch

Richard D. Bergman

2015-01-01

Documenting the environmental performance of building products is becoming increasingly common. Creating environmental product declarations (EPDs) based on life-cycle assessment (LCA) data is one approach to provide scientific documentation of the products’ environmental performance. Many U.S. structural wood products have LCA-based “eco-labels” developed under the ISO...

45 CFR 1201.6 - Procedure when testimony or production of documents is sought.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Procedure when testimony or production of...) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE PRODUCTION OR DISCLOSURE OF OFFICIAL INFORMATION IN RESPONSE TO... CONNECTION WITH FEDERAL OR STATE LITIGATION § 1201.6 Procedure when testimony or production of documents is...

22 CFR 172.5 - Procedure when testimony or production of documents is sought; general.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Procedure when testimony or production of... INFORMATION SERVICE OF PROCESS; PRODUCTION OR DISCLOSURE OF OFFICIAL INFORMATION IN RESPONSE TO COURT ORDERS... production of documents is sought; general. (a) If official Department information is sought, through...

Life-Cycle Inventory Analysis of Cellulosic Fiberboard Production in North America

Treesearch

Richard D. Bergman

2014-01-01

Documenting the environmental performance of building products is becoming widespread because of many green-marketing claims made without scientific merit (i.e., green-washing). Developing environmental product declarations (EPDs) for building products is one way to accomplish this objective for scientific documentation and to counter green-washing. EPDs are based on...

EIA model documentation: Petroleum market model of the national energy modeling system

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-12-28

The purpose of this report is to define the objectives of the Petroleum Market Model (PMM), describe its basic approach, and provide detail on how it works. This report is intended as a reference document for model analysts, users, and the public. Documentation of the model is in accordance with EIA`s legal obligation to provide adequate documentation in support of its models. The PMM models petroleum refining activities, the marketing of petroleum products to consumption regions, the production of natural gas liquids in gas processing plants, and domestic methanol production. The PMM projects petroleum product prices and sources of supplymore » for meeting petroleum product demand. The sources of supply include crude oil, both domestic and imported; other inputs including alcohols and ethers; natural gas plant liquids production; petroleum product imports; and refinery processing gain. In addition, the PMM estimates domestic refinery capacity expansion and fuel consumption. Product prices are estimated at the Census division level and much of the refining activity information is at the Petroleum Administration for Defense (PAD) District level.« less

SHARP pre-release v1.0 - Current Status and Documentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahadevan, Vijay S.; Rahaman, Ronald O.

The NEAMS Reactor Product Line effort aims to develop an integrated multiphysics simulation capability for the design and analysis of future generations of nuclear power plants. The Reactor Product Line code suite’s multi-resolution hierarchy is being designed to ultimately span the full range of length and time scales present in relevant reactor design and safety analyses, as well as scale from desktop to petaflop computing platforms. In this report, building on a several previous report issued in September 2014, we describe our continued efforts to integrate thermal/hydraulics, neutronics, and structural mechanics modeling codes to perform coupled analysis of a representativemore » fast sodium-cooled reactor core in preparation for a unified release of the toolkit. The work reported in the current document covers the software engineering aspects of managing the entire stack of components in the SHARP toolkit and the continuous integration efforts ongoing to prepare a release candidate for interested reactor analysis users. Here we report on the continued integration effort of PROTEUS/Nek5000 and Diablo into the NEAMS framework and the software processes that enable users to utilize the capabilities without losing scientific productivity. Due to the complexity of the individual modules and their necessary/optional dependency library chain, we focus on the configuration and build aspects for the SHARP toolkit, which includes capability to autodownload dependencies and configure/install with optimal flags in an architecture-aware fashion. Such complexity is untenable without strong software engineering processes such as source management, source control, change reviews, unit tests, integration tests and continuous test suites. Details on these processes are provided in the report as a building step for a SHARP user guide that will accompany the first release, expected by Mar 2016.« less

Product specification documentation standard and Data Item Descriptions (DID). Volume of the information system life-cycle and documentation standards, volume 3

NASA Technical Reports Server (NTRS)

Callender, E. David; Steinbacher, Jody

1989-01-01

This is the third of five volumes on Information System Life-Cycle and Documentation Standards which present a well organized, easily used standard for providing technical information needed for developing information systems, components, and related processes. This volume states the Software Management and Assurance Program documentation standard for a product specification document and for data item descriptions. The framework can be applied to any NASA information system, software, hardware, operational procedures components, and related processes.

36 CFR 703.17 - Procedures when testimony and/or documents are demanded.

Code of Federal Regulations, 2010 CFR

2010-07-01

.../or documents are demanded. 703.17 Section 703.17 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.17 Procedures when testimony...

15 CFR 15.13 - Demand for testimony or production of documents: Department policy.

Code of Federal Regulations, 2010 CFR

2010-01-01

... documents: Department policy. 15.13 Section 15.13 Commerce and Foreign Trade Office of the Secretary of....13 Demand for testimony or production of documents: Department policy. No employee shall in response... agency counsel. The reasons for this policy are as follows: (a) To conserve the time of Department...

75 FR 48179 - Comprehensive List of Guidance Documents at the Food and Drug Administration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-09

...The Food and Drug Administration (FDA) is publishing a comprehensive list of all guidance documents currently in use at the agency. This list is being published under FDA's Good Guidance Practices (GGPs). It is intended to inform the public of the existence and availability of all of our current guidance documents. It also provides information on guidance documents that have been added or withdrawn in the past 5 years.

[Nursing in the movies: its image during the Spanish Civil War].

PubMed

Siles González, J; García Hernández, E; Cibanal Juan, L; Gallardo Frías, Y; Lillo Crespo, M

1998-12-01

The cinema had carried out a determining role in the development of stereotypes and in a wide gamut of models related to real life situations. The objective of this analysis is to determine the influence cinema had on the image of nurses during the Spanish Civil War from 1936-1939. These are the initial hypotheses: the role of Spanish nurses during the civil war was reflected by both sides in their respective movie productions; and the image of nurses shown in these films, on both sides, presents a conflicting role concept for women in society. Following strategies developed by specialists in film analysis (Bondwell 1995, Uneso 1995, Carmona 1991) a total of 453 movie productions, 360 on the republican side and 93 on the national side, were reviewed. These films were listed in the Spanish National Films Library records. After analyzing the Spanish cinema productions during the Spanish Civil War, data relating to 453 films were identified. The genre included documents, news programs and fiction movies. 77 were produced in 1936, 235 in 1937, 102 in 1938 and 39 in 1939. A tremendous difference exists between the republican productions, 79% of the total, and the national productions. By genres, the types produced on the republican side were: in 1936, 53 documentals, 4 news programs and 9 fiction films; in 1937, 186 documentals, 5 news programs and 19 fiction films; in 1938, 72 documentals, 1 news programs and 2 fiction films; in 1939, 2 documentals and 2 fiction films. On the national side, their productions were: in 1936, 10 documentals and 1 fiction film; in 1937, 22 documentals, 2 news programs and 1 fiction film; in 1938, 19 documentals and 3 news programs; in 1939, 29 documentals and 6 fiction films. During the Spanish Civil War, movies produced by both sides made an effort to reflect their ideal woman as a stereotypical ideal nurse. This ideal nurse showed the values, ideas, aesthetics and prejudices each side held in the war.

21 CFR 312.140 - Address for correspondence.

Code of Federal Regulations, 2012 CFR

2012-04-01

... biological products regulated by CBER. Send the IND submission to the Document Control Center (HFM-99... North VII, 7620 Standish Pl., Rockville, MD 20855. (2) For biological products regulated by CDER. Send the IND submission to the CDER Therapeutic Biological Products Document Room, Center for Drug...

21 CFR 312.140 - Address for correspondence.

Code of Federal Regulations, 2013 CFR

2013-04-01

... biological products regulated by CBER. Send the IND submission to the Document Control Center (HFM-99... North VII, 7620 Standish Pl., Rockville, MD 20855. (2) For biological products regulated by CDER. Send the IND submission to the CDER Therapeutic Biological Products Document Room, Center for Drug...

27 CFR 18.25 - Organizational documents.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Organizational documents. 18.25 Section 18.25 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification Application...

27 CFR 18.25 - Organizational documents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Organizational documents. 18.25 Section 18.25 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification Application...

27 CFR 18.25 - Organizational documents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Organizational documents. 18.25 Section 18.25 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification Application...

27 CFR 18.25 - Organizational documents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Organizational documents. 18.25 Section 18.25 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification Application...

Documentation of e-cigarette use and associations with smoking from 2012 to 2015 in an integrated healthcare delivery system.

PubMed

Young-Wolff, Kelly C; Klebaner, Daniella; Folck, Bruce; Tan, Andy S L; Fogelberg, Renee; Sarovar, Varada; Prochaska, Judith J

2018-04-01

It is unclear whether use of electronic nicotine delivery systems (ENDS) precedes cigarette smoking initiation, relapse, and/or quitting. Healthcare systems with electronic health records (EHRs) provide unique data to examine ENDS use and changes in smoking. We examined the incidence of ENDS use (2012-2015) based on clinician documentation and tested whether EHR documented ENDS use is associated with twelve-month changes in patient smoking status using a matched retrospective cohort design. The sample was Kaiser Permanente Northern California (KPNC) patients aged ≥12 with documented ENDS use (N = 7926); 57% were current smokers, 35% former smokers, and 8% never-smokers. ENDS documentation incidence peaked in 2014 for current and former smokers and in 2015 for never-smokers. We matched patients with documented ENDS use to KPNC patients without documented ENDS use (N = 7926) on age, sex, race/ethnicity, and smoking status. Documented ENDS use predicted the likelihood of smoking in the following year. Among current smokers, ENDS use was associated with greater odds of quitting smoking (OR = 1.17, 95%CI = 1.05-1.31). Among former smokers, ENDS use was associated with greater odds of smoking relapse (OR = 1.53, 95%CI = 1.22-1.92). Among never-smokers, ENDS use was associated with greater odds of initiating smoking (OR = 7.41, 95%CI = 3.14-17.5). The overall number of current smokers at 12 months was slightly higher among patients with (N = 3931) versus without (N = 3850) documented ENDS use. Results support both potential harm reduction of ENDS use (quitting combustibles among current smokers) and potential for harm (relapse to combustibles among former smokers, initiation for never-smokers). Copyright © 2018 Elsevier Inc. All rights reserved.

Soil Moisture Active Passive (SMAP) Mission Level 4 Carbon (L4_C) Product Specification Document

NASA Technical Reports Server (NTRS)

Glassy, Joe; Kimball, John S.; Jones, Lucas; Reichle, Rolf H.; Ardizzone, Joseph V.; Kim, Gi-Kong; Lucchesi, Robert A.; Smith, Edmond B.; Weiss, Barry H.

2015-01-01

This is the Product Specification Document (PSD) for Level 4 Surface and Root Zone Soil Moisture (L4_SM) data for the Science Data System (SDS) of the Soil Moisture Active Passive (SMAP) project. The L4_SM data product provides estimates of land surface conditions based on the assimilation of SMAP observations into a customized version of the NASA Goddard Earth Observing System, Version 5 (GEOS-5) land data assimilation system (LDAS). This document applies to any standard L4_SM data product generated by the SMAP Project.

Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance.

PubMed

2006-10-11

This guidance describes how the FDA evaluates patient-reported outcome (PRO) instruments used as effectiveness endpoints in clinical trials. It also describes our current thinking on how sponsors can develop and use study results measured by PRO instruments to support claims in approved product labeling (see appendix point 1). It does not address the use of PRO instruments for purposes beyond evaluation of claims made about a drug or medical product in its labeling. By explicitly addressing the review issues identified in this guidance, sponsors can increase the efficiency of their endpoint discussions with the FDA during the product development process, streamline the FDA's review of PRO endpoint adequacy, and provide optimal information about the patient's perspective of treatment benefit at the time of product approval. A PRO is a measurement of any aspect of a patient's health status that comes directly from the patient (i.e., without the interpretation of the patient's responses by a physician or anyone else). In clinical trials, a PRO instrument can be used to measure the impact of an intervention on one or more aspects of patients' health status, hereafter referred to as PRO concepts, ranging from the purely symptomatic (response of a headache) to more complex concepts (e.g., ability to carry out activities of daily living), to extremely complex concepts such as quality of life, which is widely understood to be a multidomain concept with physical, psychological, and social components. Data generated by a PRO instrument can provide evidence of a treatment benefit from the patient perspective. For this data to be meaningful, however, there should be evidence that the PRO instrument effectively measures the particular concept that is studied. Generally, findings measured by PRO instruments may be used to support claims in approved product labeling if the claims are derived from adequate and well-controlled investigations that use PRO instruments that reliably and validly measure the specific concepts at issue. The glossary defines many of the terms used in this guidance. In particular, the term instrument refers to the actual questions or items contained in a questionnaire or interview schedule along with all the additional information and documentation that supports the use of these items in producing a PRO measure (e.g., interviewer training and instructions, scoring and interpretation manual). The term conceptual framework refers to how items are grouped according to subconcepts or domains (e.g., the item walking without help may be grouped with another item, walking with difficulty, within the domain of ambulation, and ambulation may be further grouped into the concept of physical ability). FDA's guidance documents, including this guidance, do not establish legally enforceable responsibilities. Instead, guidance documents describe the Agency's current thinking on a topic and should be viewed only as recommendations, unless specific regulatory or statutory requirements are cited. The use of the word should in Agency guidance documents means that something is suggested or recommended but not required. First publication of the Draft Guidance by the Food and Drug Administration--February 2006.

Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance

PubMed Central

2006-01-01

This guidance describes how the FDA evaluates patient-reported outcome (PRO) instruments used as effectiveness endpoints in clinical trials. It also describes our current thinking on how sponsors can develop and use study results measured by PRO instruments to support claims in approved product labeling (see appendix point 1). It does not address the use of PRO instruments for purposes beyond evaluation of claims made about a drug or medical product in its labeling. By explicitly addressing the review issues identified in this guidance, sponsors can increase the efficiency of their endpoint discussions with the FDA during the product development process, streamline the FDA's review of PRO endpoint adequacy, and provide optimal information about the patient's perspective of treatment benefit at the time of product approval. A PRO is a measurement of any aspect of a patient's health status that comes directly from the patient (i.e., without the interpretation of the patient's responses by a physician or anyone else). In clinical trials, a PRO instrument can be used to measure the impact of an intervention on one or more aspects of patients' health status, hereafter referred to as PRO concepts, ranging from the purely symptomatic (response of a headache) to more complex concepts (e.g., ability to carry out activities of daily living), to extremely complex concepts such as quality of life, which is widely understood to be a multidomain concept with physical, psychological, and social components. Data generated by a PRO instrument can provide evidence of a treatment benefit from the patient perspective. For this data to be meaningful, however, there should be evidence that the PRO instrument effectively measures the particular concept that is studied. Generally, findings measured by PRO instruments may be used to support claims in approved product labeling if the claims are derived from adequate and well-controlled investigations that use PRO instruments that reliably and validly measure the specific concepts at issue. The glossary defines many of the terms used in this guidance. In particular, the term instrument refers to the actual questions or items contained in a questionnaire or interview schedule along with all the additional information and documentation that supports the use of these items in producing a PRO measure (e.g., interviewer training and instructions, scoring and interpretation manual). The term conceptual framework refers to how items are grouped according to subconcepts or domains (e.g., the item walking without help may be grouped with another item, walking with difficulty, within the domain of ambulation, and ambulation may be further grouped into the concept of physical ability). FDA's guidance documents, including this guidance, do not establish legally enforceable responsibilities. Instead, guidance documents describe the Agency's current thinking on a topic and should be viewed only as recommendations, unless specific regulatory or statutory requirements are cited. The use of the word should in Agency guidance documents means that something is suggested or recommended but not required. First publication of the Draft Guidance by the Food and Drug Administration- February 2006. PMID:17034633

27 CFR 18.17 - Retention of documents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Retention of documents. 18.17 Section 18.17 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Administrative and...

27 CFR 18.17 - Retention of documents.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Retention of documents. 18.17 Section 18.17 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Administrative and...

27 CFR 18.17 - Retention of documents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Retention of documents. 18.17 Section 18.17 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Administrative and...

27 CFR 18.17 - Retention of documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Retention of documents. 18.17 Section 18.17 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Administrative and...

SeaWiFS technical report series. Volume 1: An overview of SeaWiFS and ocean color

NASA Technical Reports Server (NTRS)

Hooker, Stanford B. (Editor); Firestone, Elaine R. (Editor); Esaias, Wayne E.; Feldman, Gene C.; Gregg, Watson W.; Mcclain, Charles R.

1992-01-01

The purpose of this series of technical reports is to provide current documentation of the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) Project activities, instrument performance, algorithms, and operations. This documentation is necessary to ensure that critical information related to the quality and calibration of the satellite data is available to the scientific community. SeaWiFS will bring to the ocean community a welcomed and improved renewal of the ocean color remote sensing capability lost when the Nimbus-7 Coastal Zone Color Scanner (CZCS) ceased operating in 1986. The goal of SeaWiFS, scheduled to be launched in August 1993, is to examine oceanic factors that affect global change. Because of the role of phytoplankton in the global carbon cycle, data obtained from SeaWiFS will be used to assess the ocean's role in this cycle, as well as other biogeochemical cycles. SeaWiFS data will be used to help elucidate the magnitude and variability of the annual cycle of primary production by marine phytoplankton and to determine the distribution and timing of spring blooms. The observations will help to visualize the dynamics of ocean and costal currents, the physics of mixing, and the relationships between ocean physics and large-scale patterns of productivity. The data will help fill the gap in ocean biological observations between those of the CZCS and the upcoming Moderate Resolution Imaging Spectrometer (MODIS) on the Earth Observing System-A (EOS-A) satellite.

36 CFR 703.16 - Policy on presentation of testimony and production of documents.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.16 Policy on presentation of... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Policy on presentation of testimony and production of documents. 703.16 Section 703.16 Parks, Forests, and Public Property LIBRARY OF...

In Situ Aerosol Optical Thickness Collected by the SIMBIOS Program (1997-2000): Protocols, and and Data QC and Analysis

NASA Technical Reports Server (NTRS)

Fargion, Giulietta S.; Barnes, Robert; McClain, Charles

2001-01-01

The purpose of this technical report is to provide current documentation of the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project Office activities on in situ aerosol optical thickness (i.e., protocols, and data QC and analysis). This documentation is necessary to ensure that critical information is related to the scientific community and NASA management. This critical information includes the technical difficulties and challenges of validating and combining ocean color data from an array of independent satellite systems to form consistent and accurate global bio-optical time series products. This technical report is not meant as a substitute for scientific literature. Instead, it will provide a ready and responsive vehicle for the multitude of technical reports issued by an operational project.

Year 2000 (Y2K) computer compliance guide; guidance for FDA personnel. Food and Drug Administration. Notice.

PubMed

1999-05-14

The Food and Drug Administration (FDA) is announcing the availability of a new compliance policy guide (CPG) entitled "Year 2000 (Y2K) Computer Compliance" (section 160-800). This guidance document represents the agency's current thinking on the manufacturing and distribution of domestic and imported products regulated by FDA using computer systems that may not perform properly before, or during, the transition to the year 2000 (Y2K). The text of the CPG is included in this notice. This compliance guidance document is an update to the Compliance Policy Guides Manual (August 1996 edition). It is a new CPG, and it will be included in the next printing of the Compliance Policy Guides Manual. This CPG is intended for FDA personnel, and it is available electronically to the public.

International Space Station Execution Replanning Process: Trends and Implications

NASA Technical Reports Server (NTRS)

McCormick, Robet J.

2007-01-01

International Space Station is a joint venture. Because of this, ISS execution planning- planning within the week for the ISS requires coordination across multiple partner, and the associated processes and tools to allow this coordination to occur. These processes and tools are currently defined and are extensively used. This paper summarizes these processes, and documents the current data trends associated with these processes and tools, with a focus on the metrics provided from the ISS Planning Product Change Request (PPCR) tool. As NASA's Vision for Space Exploration and general Human spaceflight trends are implemented, the probability of joint venture long duration programs such as ISS, with varying levels of intergovernmental and/or corporate partnership, will increase. Therefore, the results of this PPCR analysis serve as current Lessons learned for the ISS and for further similar ventures.

21 CFR 17.23 - Discovery.

Code of Federal Regulations, 2010 CFR

2010-04-01

... presiding officer, a party may make a request to another party for production, inspection, and copying of... section, are not authorized. (d)(1) Within 10 days of service of a request for production of documents, a... showing that documents should be produced is on the party seeking their production. (e) The presiding...

76 FR 9028 - Guidance for Industry: Potency Tests for Cellular and Gene Therapy Products; Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-16

...] Guidance for Industry: Potency Tests for Cellular and Gene Therapy Products; Availability AGENCY: Food and... the availability of a document entitled ``Guidance for Industry: Potency Tests for Cellular and Gene Therapy Products'' dated January 2011. The guidance document provides manufacturers of cellular and gene...

Tissue banking in South Africa: a 19-year history.

PubMed

Lindeque, B G P; Lindeque, A M; Hausner, H; Le Roux, T L B

2005-01-01

The establishment of a Tissue Bank and the science of Tissue Banking in South Africa started in the 1960s and is still developing. This article describes the development and growth of Tissue Banking in South Africa. The current emphasis is to supply viable bone products that have been produced under the best possible quality controlled circumstances; with the collaboration between different Organ Donation Organisations. Through collaboration, a dramatic increase in the number of donors was noted over the years. Concurrently, there was a dramatic increase in the usage of different allograft products and now necessitates the development of new graft materials for expanding patient options. As an ongoing concern, the Tissue Bank in South Africa experienced an ever increase in costs to enhance quality/safety controls: increase in historical patient information, documentation and serological testing in a population struggling to control HIV. To date, the South African Tissue Bank has not experienced any untoward patient incidence since the 1960s and currently is getting over 500 donors per year.

Use of Probiotics in Aquaculture

PubMed Central

Martínez Cruz, Patricia; Ibáñez, Ana L.; Monroy Hermosillo, Oscar A.; Ramírez Saad, Hugo C.

2012-01-01

The growth of aquaculture as an industry has accelerated over the past decades; this has resulted in environmental damages and low productivity of various crops. The need for increased disease resistance, growth of aquatic organisms, and feed efficiency has brought about the use of probiotics in aquaculture practices. The first application of probiotics occurred in 1986, to test their ability to increase growth of hydrobionts (organisms that live in water). Later, probiotics were used to improve water quality and control of bacterial infections. Nowadays, there is documented evidence that probiotics can improve the digestibility of nutrients, increase tolerance to stress, and encourage reproduction. Currently, there are commercial probiotic products prepared from various bacterial species such as Bacillus sp., Lactobacillus sp., Enterococcus sp., Carnobacterium sp., and the yeast Saccharomyces cerevisiae among others, and their use is regulated by careful management recommendations. The present paper shows the current knowledge of the use of probiotics in aquaculture, its antecedents, and safety measures to be carried out and discusses the prospects for study in this field. PMID:23762761

Life-Cycle Inventory Analysis of Laminated Veneer Lumber Production in the United States

Treesearch

Richard D. Bergman

2015-01-01

Documenting the environmental performance of building products is becoming increasingly common. Developing environmental product declarations (EPDs) based on life-cycle assessment (LCA) data is one way to provide scientific documentation. Many U.S. structural wood products have LCA-based “eco-labels” using the ISO standard. However, the standard requires underlying...

Whittier Tunnel, Transportation & Public Facilities, State of Alaska

Science.gov Websites

ONLINE (or choose to download in Adobe PDF or Excel format) Summer May 1 - Sept 30 PDF document | Excel document Winter Oct 1 - Apr 30 PDF document | Excel document Current Regulations: PDF document | Word

Parents' childhood socioeconomic circumstances are associated with their children's asthma outcomes.

PubMed

Chen, Edith; Shalowitz, Madeleine U; Story, Rachel E; Ehrlich, Katherine B; Manczak, Erika M; Ham, Paula J; Le, Van; Miller, Gregory E

2017-09-01

Previous literature documents associations between low socioeconomic status (SES) and poor health outcomes, including asthma. However, this literature has largely focused on the effects of current family circumstances. We sought to test an intergenerational hypothesis, that the childhood SES that parents experience will be associated with asthma outcomes in their children, independent of effects of current family SES. Second, we aimed to test whether this association is in part due to difficulties in current parent-child relationships. This was an observational study, whereby 150 parents were interviewed about their childhood SES and their children (physician-diagnosed asthma, ages 9-17 years) were interviewed about current family stress. Asthma control was assessed by parent report and child report (primary outcome), and blood was collected from children to measure cytokine production relevant to asthma (secondary outcomes). To the degree that parents had lower childhood SES, their offspring showed worse asthma outcomes across multiple indicators. This included lower asthma control scores (parent and child report, Ps < .05), and greater stimulated production of T H 2 and T H 1 cytokines by PBMCs (Ps < .05). These associations were independent of current family SES. Mediation analyses were consistent with a scenario wherein parents with low childhood SES had current family relationships that were more stressful, and these difficulties, in turn, related to worse asthma control and greater cytokine production in children. These results suggest the potential "long reach" of low SES across generations, and the importance of expanding theories of how the social environment can affect childhood asthma to include characteristics of earlier generations. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

16 CFR 1051.6 - Documents not considered petitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... which addresses a topic or involves a product outside the jurisdiction of the Commission will not be... Secretary, if appropriate, will forward to the appropriate agency documents which address products or topics...

Co-occurrence of tobacco product use, substance use, and mental health problems among adults: Findings from Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health (PATH) Study.

PubMed

Conway, Kevin P; Green, Victoria R; Kasza, Karin A; Silveira, Marushka L; Borek, Nicolette; Kimmel, Heather L; Sargent, James D; Stanton, Cassandra; Lambert, Elizabeth; Hilmi, Nahla; Reissig, Chad J; Jackson, Kia J; Tanski, Susanne E; Maklan, David; Hyland, Andrew J; Compton, Wilson M

2017-08-01

Although non-cigarette tobacco product use is increasing among U.S. adults, their associations with substance use and mental health problems are unclear. This study examined co-occurrence of tobacco use, substance use, and mental health problems, and its moderation by gender, among 32,202U.S. adults from Wave 1 (2013-2014) of the nationally representative longitudinal Population Assessment of Tobacco and Health (PATH) Study. Participants self-reported current cigarette, e-cigarette, traditional cigar, cigarillo, filtered cigar, hookah, smokeless tobacco and other tobacco product use; past year alcohol, marijuana, and other drug use; and past year substance use, internalizing and externalizing problems. Compared to non-current tobacco users, current users were more likely to report alcohol or drug use (adjusted odds ratio (AOR)=2.6; 95% confidence interval (CI): 2.3, 2.9), with the strongest associations observed for cigarillo and hookah users. Across all tobacco product groups, users were more likely to report internalizing (AOR=1.9; 95% CI: 1.7, 2.1), externalizing (AOR=1.6; 95% CI: 1.5, 1.8), and substance use (AOR=3.4; 95% CI: 2.9, 4.1) problems than non-users. Gender moderated many of these associations and, of these, all non-cigarette tobacco product associations were stronger among females. This nationally representative study of U.S. adults is the first to comprehensively document tobacco use, substance use, and mental health comorbidities across the range of currently available tobacco products, while also demonstrating that female tobacco users are at increased risk for substance use and mental health problems. These findings may point to gender differences in vulnerability and suggest that interventions incorporate gender-specific approaches. Copyright © 2017 Elsevier B.V. All rights reserved.

Theater Blood Application Was Not Effectively Developed and Implemented

DTIC Science & Technology

2015-07-17

blood product by unit; and • monitor non- Food and Drug Administration Blood Product Testing. The CONOPS document also identified over 400 specific...time of a transfusion. However, this requirement was not identified in the CONOPS document. Further, PEO DHCS officials provided a traceability ...the CONOPS document, requirements management database, and the traceability matrix increased the risk that the Theater Blood Application

Outcomes from the Productivity Places Program 2009: Terms and Definitions. Support Document

ERIC Educational Resources Information Center

National Centre for Vocational Education Research (NCVER), 2009

2009-01-01

This document covers the data terms used in the "Outcomes from the Productivity Places Program 2009" report and its associated data tables. The primary purpose of this document is to assist users of the report to understand the specific data terms used within it. Terms that appear in the report are listed in alphabetical order with the…

Requirements for color technology

NASA Astrophysics Data System (ADS)

Campbell, Ronald B., Jr.

1993-06-01

The requirements for color technology in the general office are reviewed. The two most salient factors driving the requirements for color are the information explosion and the virtually negligible growth in white collar productivity in the recent past. Accordingly, the business requirement upon color technology is that it be utilized in an effective and efficient manner to increase office productivity. Recent research on productivity and growth has moved beyond the classical two factor productivity model of labor and capital to explicitly include knowledge as a third and vital factor. Documents are agents of knowledge in the general office. Documents articulate, express, disseminate, and communicate knowledge. The central question addressed here is how can color, in conjunction with other techniques such as graphics and document design, improve the growth of knowledge? The central thesis is that the effective use of color to convert information into knowledge is one of the most powerful ways to increase office productivity. Material on the value of color is reviewed. This material is related to the role of documents. Document services are the way in which users access and utilize color technology. The requirements for color technology are then defined against the services taxonomy.

ShakeMap manual: technical manual, user's guide, and software guide

USGS Publications Warehouse

Wald, David J.; Worden, Bruce C.; Quitoriano, Vincent; Pankow, Kris L.

2005-01-01

ShakeMap (http://earthquake.usgs.gov/shakemap) --rapidly, automatically generated shaking and intensity maps--combines instrumental measurements of shaking with information about local geology and earthquake location and magnitude to estimate shaking variations throughout a geographic area. The results are rapidly available via the Web through a variety of map formats, including Geographic Information System (GIS) coverages. These maps have become a valuable tool for emergency response, public information, loss estimation, earthquake planning, and post-earthquake engineering and scientific analyses. With the adoption of ShakeMap as a standard tool for a wide array of users and uses came an impressive demand for up-to-date technical documentation and more general guidelines for users and software developers. This manual is meant to address this need. ShakeMap, and associated Web and data products, are rapidly evolving as new advances in communications, earthquake science, and user needs drive improvements. As such, this documentation is organic in nature. We will make every effort to keep it current, but undoubtedly necessary changes in operational systems take precedence over producing and making documentation publishable.

Product-oriented Software Certification Process for Software Synthesis

NASA Technical Reports Server (NTRS)

Nelson, Stacy; Fischer, Bernd; Denney, Ewen; Schumann, Johann; Richardson, Julian; Oh, Phil

2004-01-01

The purpose of this document is to propose a product-oriented software certification process to facilitate use of software synthesis and formal methods. Why is such a process needed? Currently, software is tested until deemed bug-free rather than proving that certain software properties exist. This approach has worked well in most cases, but unfortunately, deaths still occur due to software failure. Using formal methods (techniques from logic and discrete mathematics like set theory, automata theory and formal logic as opposed to continuous mathematics like calculus) and software synthesis, it is possible to reduce this risk by proving certain software properties. Additionally, software synthesis makes it possible to automate some phases of the traditional software development life cycle resulting in a more streamlined and accurate development process.

GMO foods and crops: Africa's choice.

PubMed

Paarlberg, Robert

2010-11-30

There is a scientific consensus, even in Europe, that the GMO foods and crops currently on the market have brought no documented new risks either to human health or to the environment. Europe has decided to stifle the use of this new technology, not because of the presence of risks, but because of the absence so far of direct benefits to most Europeans. Farmers in Europe are few in number, and they are highly productive even without GMOs. In Africa, by contrast, 60% of all citizens are still farmers and they are not yet highly productive. For Africa, the choice to stifle new technology with European-style regulations carries a much higher cost. Copyright © 2010 Elsevier B.V. All rights reserved.

How tobacco companies have used package quantity for consumer targeting.

PubMed

Persoskie, Alexander; Donaldson, Elisabeth A; Ryant, Chase

2018-05-31

Package quantity refers to the number of cigarettes or amount of other tobacco product in a package. Many countries restrict minimum cigarette package quantities to avoid low-cost packs that may lower barriers to youth smoking. We reviewed Truth Tobacco Industry Documents to understand tobacco companies' rationales for introducing new package quantities, including companies' expectations and research regarding how package quantity may influence consumer behaviour. A snowball sampling method (phase 1), a static search string (phase 2) and a follow-up snowball search (phase 3) identified 216 documents, mostly from the 1980s and 1990s, concerning cigarettes (200), roll-your-own tobacco (9), smokeless tobacco (6) and 'smokeless cigarettes' (1). Companies introduced small and large packages to motivate brand-switching and continued use among current users when faced with low market share or threats such as tax-induced price increases or competitors' use of price promotions. Companies developed and evaluated package quantities for specific brands and consumer segments. Large packages offered value-for-money and matched long-term, heavy users' consumption rates. Small packages were cheaper, matched consumption rates of newer and lighter users, and increased products' novelty, ease of carrying and perceived freshness. Some users also preferred small packages as a way to try to limit consumption or quit. Industry documents speculated about many potential effects of package quantity on appeal and use, depending on brand and consumer segment. The search was non-exhaustive, and we could not assess the quality of much of the research or other information on which the documents relied. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

The US Orphan Drug Act: rare disease research stimulator or commercial opportunity?

PubMed

Wellman-Labadie, Olivier; Zhou, Youwen

2010-05-01

This study investigates issues associated with the United States Orphan Drug Act. A comprehensive orphan drug database was compiled from FDA data and corporate annual reports of major pharmaceutical companies. Analysis allowed the generation of a descriptive orphan drug portrait as well as documentation of orphan drugs along their lifecycle. Currently, 2002 products have obtained orphan drug designation with 352 drugs obtaining FDA approval. Approximately 33% of orphan drugs are oncology products. On average, products obtain 1.7 orphan designations with approximately 70% obtaining a single designation. At least 9% of orphan drugs have reached blockbuster status with two-thirds having two or more designations. An additional 25 orphan drugs had sales exceeding US$ 100 million in 2008 alone. Since 1983, at least 14 previously discontinued products have been recycled as orphan drugs. The United States Orphan Drug Act has created issues which, in some cases, have led to commercial and ethical abuses. Orphan Drug Act reform is necessary but current incentives, including 7 year market exclusivity, should be maintained in order to favour patients as well as economic prosperity. Suggested reforms include price regulation, subsidy paybacks for profitable drugs and the establishment of an International Orphan Drug Office. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.

Quantitative Technique for Comparing Simulant Materials through Figures of Merit

NASA Technical Reports Server (NTRS)

Rickman, Doug; Hoelzer, Hans; Fourroux, Kathy; Owens, Charles; McLemore, Carole; Fikes, John

2007-01-01

The 1989 workshop report entitled Workshop on Production and Uses of Simulated Lunar Materials and the Lunar Regolith Simulant Materials: Recommendations for Standardization, Production, and Usage, NASA Technical Publication both identified and reinforced a need for a set of standards and requirements for the production and usage of the Lunar simulant materials. As NASA prepares to return to the Moon, and set out to Mars, a set of early requirements have been developed for simulant materials and the initial methods to produce and measure those simulants have been defined. Addressed in the requirements document are: 1) a method for evaluating the quality of any simulant of a regolith, 2) the minimum characteristics for simulants of Lunar regolith, and 3) a method to produce simulants needed for NASA's Exploration mission. As an extension of the requirements document a method to evaluate new and current simulants has been rigorously defined through the mathematics of Figures of Merit (FoM). Requirements and techniques have been developed that allow the simulant provider to compare their product to a standard reference material through Figures of Merit. Standard reference material may be physical material such as the Apollo core samples or material properties predicted for any landing site. The simulant provider is not restricted to providing a single "high fidelity" simulant, which may be costly to produce. The provider can now develop "lower fidelity" simulants for engineering applications such as drilling and mobility applications.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mancuso, C.A.

The INEL Database of BNCT Information and Treatment (TIDBIT) has been under development for several years. Late in 1993, a new software development team took over the project and did and assessment of the current implementation status, and determined that the user interface was unsatisfactory for the expected users and that the data structures were out of step with the current state of reality. The team evaluated several tools that would improve the user interface to make the system easier to use. Uniface turned out to be the product of choice. During 1994, TIDBIT got its name, underwent a completemore » change of appearance, had a major overhaul to the data structures that support the application, and system documentation was begun. A prototype of the system was demonstrated in September 1994.« less

Development and implementation of clinical trial protocol templates at the National Institute of Allergy and Infectious Diseases.

PubMed

Bridge, Heather; Smolskis, Mary; Bianchine, Peter; Dixon, Dennis O; Kelly, Grace; Herpin, Betsey; Tavel, Jorge

2009-08-01

A clinical research protocol document must reflect both sound scientific rationale as well as local, national and, when applicable, international regulatory and human subject protections requirements. These requirements originate from a variety of sources, undergo frequent revision and are subject to interpretation. Tools to assist clinical investigators in the production of clinical protocols could facilitate navigating these requirements and ultimately increase the efficiency of clinical research. The National Institute of Allergy and Infectious Diseases (NIAID) developed templates for investigators to serve as the foundation for protocol development. These protocol templates are designed as tools to support investigators in developing clinical protocols. NIAID established a series of working groups to determine how to improve its capacity to conduct clinical research more efficiently and effectively. The Protocol Template Working Group was convened to determine what protocol templates currently existed within NIAID and whether standard NIAID protocol templates should be produced. After review and assessment of existing protocol documents and requirements, the group reached consensus about required and optional content, determined the format and identified methods for distribution as well as education of investigators in the use of these templates. The templates were approved by the NIAID Executive Committee in 2006 and posted as part of the NIAID Clinical Research Toolkit [1] website for broad access. These documents require scheduled revisions to stay current with regulatory and policy changes. The structure of any clinical protocol template, whether comprehensive or specific to a particular study phase, setting or design, affects how it is used by investigators. Each structure presents its own set of advantages and disadvantages. While useful, protocol templates are not stand-alone tools for creating an optimal protocol document, but must be complemented by institutional resources and support. Education and guidance of investigators in the appropriate use of templates is necessary to ensure a complete yet concise protocol document. Due to changing regulatory requirements, clinical protocol templates cannot become static, but require frequent revisions.

3 CFR - Designating the Chairperson of the Defense Production Act Committee

Code of Federal Regulations, 2011 CFR

2011-01-01

... 3 The President 1 2011-01-01 2011-01-01 false Designating the Chairperson of the Defense Production Act Committee Presidential Documents Other Presidential Documents Memorandum of May 19, 2010 Designating the Chairperson of the Defense Production Act Committee Memorandum for the Secretary of Defense [and] the Secretary of Homeland Security...

40 CFR 2.402 - Policy on presentation of testimony and production of documents.

Code of Federal Regulations, 2010 CFR

2010-07-01

... GENERAL PUBLIC INFORMATION Testimony by Employees and Production of Documents in Civil Legal Proceedings Where the United States Is Not a Party § 2.402 Policy on presentation of testimony and production of... request of a State or local government or State legislative committee. (b) Except as permitted by...

Survey of international regulatory bioequivalence recommendations for approval of generic topical dermatological drug products.

PubMed

Braddy, April C; Davit, Barbara M; Stier, Ethan M; Conner, Dale P

2015-01-01

The objective of this article is to discuss the similarities and differences in accepted bioequivalence (BE) approaches for generic topical dermatological drug products between international regulatory authorities and organizations. These drug products are locally applied and not intended for systemic absorption. Therefore, the BE approaches which serve as surrogates to establish safety and efficacy for topical dosage forms tend to differ from the traditional solid oral dosage forms. We focused on 15 different international jurisdictions and organizations that currently participate in the International Generic Drug Regulators Pilot Project. These are Australia, Brazil, Canada, China, Chinese Taipei, the European Medicines Association (EMA), Japan, Mexico, New Zealand, Singapore (a member of the Association of Southeast Asian Nations), South Africa, South Korea, Switzerland, the USA and the World Health Organization (WHO). Upon evaluation, we observed that currently only Canada, the EMA, Japan, and the USA have specific guidance documents for topical drug products. Across all jurisdictions and organizations, the three approaches consistently required are (1) BE studies with clinical endpoints for most topical drug products; (2) in vivo pharmacodynamic studies, in particular the vasoconstrictor assay for topical corticosteroids; and (3) waivers from BE study requirements for topical solutions. Japan, South Africa, the USA, and the WHO are also making strides to accept other BE approaches such as in vivo pharmacokinetic studies for BE assessment, in vivo dermatopharmacokinetic studies and/or BE studies with in vitro endpoints.

Jojoba: a wax-producing shrub of the Sonoran desert: literature review and annotated bibliography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sherbrooke, W.C.; Haase, E.F.

Jojoba (Simmondsia chinensis) has recently received attention because its seed oil content of about 50% is a possible substitute for sperm whale oil. This document reviews the literature on its botany and natural history, and the utilization of the seed oil and the production of seed. Current research activities are also noted. However, the major portion of the paper consists of the annotated bibliography, which appears as a computer print-out with citations and key-words. Author and key-word indexes are included.

NASA geometry data exchange specification for computational fluid dynamics (NASA IGES)

NASA Technical Reports Server (NTRS)

Blake, Matthew W.; Kerr, Patricia A.; Thorp, Scott A.; Jou, Jin J.

1994-01-01

This document specifies a subset of an existing product data exchange specification that is widely used in industry and government. The existing document is called the Initial Graphics Exchange Specification. This document, a subset of IGES, is intended for engineers analyzing product performance using tools such as computational fluid dynamics (CFD) software. This document specifies how to define mathematically and exchange the geometric model of an object. The geometry is represented utilizing nonuniform rational B-splines (NURBS) curves and surfaces. Only surface models are represented; no solid model representation is included. This specification does not include most of the other types of product information available in IGES (e.g., no material properties or surface finish properties) and does not provide all the specific file format details of IGES. The data exchange protocol specified in this document is fully conforming to the American National Standard (ANSI) IGES 5.2.

A Literature Review on Prevalence of Gender Differences and Intersections with Other Vulnerabilities to Tobacco Use in the United States, 2004–2014

PubMed Central

Higgins, Stephen T.; Kurti, Allison N.; Redner, Ryan; White, Thomas J.; Gaalema, Diann E.; Roberts, Megan E.; Doogan, Nathan J.; Tidey, Jennifer W.; Miller, Mollie E.; Stanton, Cassandra A.; Henningfield, Jack E.; Atwood, Gary S.

2015-01-01

This report describes results from a systematic literature review examining gender differences in U.S. prevalence rates of current use of tobacco and nicotine delivery products and how they intersect with other vulnerabilities to tobacco use. We searched PubMed on gender differences in tobacco use across the years 2004–2014. For inclusion, reports had to be in English, in a peer-reviewed journal or federal government report, report prevalence rates for current use of a tobacco product in males and females, and use a U.S. nationally representative sample. Prevalence rates were generally higher in males than females across all products. This pattern remained stable despite changes over time in overall prevalence rates. Gender differences generally were robust when intersecting with other vulnerabilities, although decreases in the magnitude of gender differences were noted among younger and older users, and among educational levels and race/ethnic groups associated with the highest or lowest prevalence rates. Overall, these results document a pervasive association of gender with vulnerability to tobacco use that acts additively with other vulnerabilities. These vulnerabilities should be considered whenever formulating tobacco control and regulatory policies. PMID:26123717

An Independent Scientific Assessment of Well Stimulation in California Volume I

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jane C.S. Long; Laura C. Feinstein; Birkholzer, Jens

In 2013, the California Legislature passed Senate Bill 4 (SB 4), setting the framework for regulation of well stimulation technologies in California, including hydraulic fracturing. SB 4 also requires the California Natural Resources Agency to conduct an independent scientific study of well stimulation technologies in California to assess current and potential future practices, including the likelihood that well stimulation technologies could enable extensive new petroleum production in the state, evaluate the impacts of well stimulation technologies and the gaps in data that preclude this understanding, identify risks associated with current practices, and identify alternative practices which might limit these risks.more » The study is issued in three volumes. This document, Volume I, provides the factual basis describing well stimulation technologies, how and where operators deploy these technologies for oil and gas production in California, and where they might enable production in the future. Volume II discusses how well stimulation affects water, the atmosphere, seismic activity, wildlife and vegetation, traffic, light and noise levels; it will also explore human health hazards, and identify data gaps and alternative practices. Volume III presents case studies to assess environmental issues and qualitative« less

A Decade of Annual National Land Cover Products - the Cropland Data Layer

NASA Astrophysics Data System (ADS)

Mueller, R.; Johnson, D. M.; Sandborn, A.; Willis, P.; Ebinger, L.; Yang, Z.; Seffrin, R.; Boryan, C. G.; Hardin, R.

2017-12-01

The Cropland Data Layer (CDL) is a national land cover product produced by the US Department of Agriculture/National Agricultural Statistics Service (NASS) to assess planted crop acreage on an annual basis. The 2017 CDL product serves as the decadal anniversary for the mapping of conterminous US agriculture. The CDL is a supervised land cover classification derived from medium resolution Earth observing satellites that capture crop phenology throughout the growing season, leveraging confidentially held ground reference information from the USDA Farm Service Agency (FSA) as training data. The CDL currently uses ancillary geospatial data from the US Geological Survey's National Land Cover Database (NLCD), and Imperviousness and Forest Canopy layers as well as the National Elevation Dataset as training for the non-agricultural domain. Accuracy assessments are documented and released annually with metadata publication. NASS is currently reprocessing the 2008 and 2009 CDL products to 30m resolution. They were originally processed and released at 56m based on the Resourcesat-1 AWiFS sensor. Additionally, best practices learned from processing the FSA ground reference data were applied to the historical training set, providing an enhanced classification at 30m. The release of these reprocessed products in the fall of 2017, along with the 2017 CDL annual product will be discussed and will complete a decade's worth of annual 30m products. Discussions of change and trend analytics as well as partnerships with key industry stakeholders will be displayed on the evolution and improvements made to this decadal geospatial crop specific land cover product.

Adverse Event extraction from Structured Product Labels using the Event-based Text-mining of Health Electronic Records (ETHER)system.

PubMed

Pandey, Abhishek; Kreimeyer, Kory; Foster, Matthew; Botsis, Taxiarchis; Dang, Oanh; Ly, Thomas; Wang, Wei; Forshee, Richard

2018-01-01

Structured Product Labels follow an XML-based document markup standard approved by the Health Level Seven organization and adopted by the US Food and Drug Administration as a mechanism for exchanging medical products information. Their current organization makes their secondary use rather challenging. We used the Side Effect Resource database and DailyMed to generate a comparison dataset of 1159 Structured Product Labels. We processed the Adverse Reaction section of these Structured Product Labels with the Event-based Text-mining of Health Electronic Records system and evaluated its ability to extract and encode Adverse Event terms to Medical Dictionary for Regulatory Activities Preferred Terms. A small sample of 100 labels was then selected for further analysis. Of the 100 labels, Event-based Text-mining of Health Electronic Records achieved a precision and recall of 81 percent and 92 percent, respectively. This study demonstrated Event-based Text-mining of Health Electronic Record's ability to extract and encode Adverse Event terms from Structured Product Labels which may potentially support multiple pharmacoepidemiological tasks.

Technology's Impact on Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rachel Amann; Ellis Deweese; Deborah Shipman

2009-06-30

As part of a cooperative agreement with the United States Department of Energy (DOE) - entitled Technology's Impact on Production: Developing Environmental Solutions at the State and National Level - the Interstate Oil and Gas Compact Commission (IOGCC) has been tasked with assisting state governments in the effective, efficient, and environmentally sound regulation of the exploration and production of natural gas and crude oil, specifically in relation to orphaned and abandoned wells and wells nearing the end of productive life. Project goals include: (1) Developing (a) a model framework for prioritization and ranking of orphaned or abandoned well sites; (b)more » a model framework for disbursement of Energy Policy Act of 2005 funding; and (c) a research study regarding the current status of orphaned wells in the nation. (2) Researching the impact of new technologies on environmental protection from a regulatory perspective. Research will identify and document (a) state reactions to changing technology and knowledge; (b) how those reactions support state environmental conservation and public health; and (c) the impact of those reactions on oil and natural gas production. (3) Assessing emergent technology issues associated with wells nearing the end of productive life. Including: (a) location of orphaned and abandoned well sites; (b) well site remediation; (c) plugging materials; (d) plug placement; (e) the current regulatory environment; and (f) the identification of emergent technologies affecting end of life wells. New Energy Technologies - Regulating Change, is the result of research performed for Tasks 2 and 3.« less

Toxicity testing of polymer materials for dialysis equipment: reconsidering in vivo testing.

PubMed

Sauer, U G; Liebsch, M; Kolar, R

2000-01-01

In fulfilment of the aims of the European Union Biocidal Directive (Directive 98/8/EC), Technical Guidance Documents are currently being compiled. Part I of these Technical Guidance Documents covers data requirements for active substances and biocidal products. The Three Rs principle has been applied in certain parts of the toxicity and ecotoxicity testing scheme for pesticides, such as testing for acute oral toxicity, skin and eye irritation, skin sensitisation, and dermal absorption. Further recommendations on how to proceed with regard to the continuing replacement, reduction and refinement of animal experiments in this field of regulatory testing are included for consideration. In this context, besides stressing the necessity to validate and accept further alternatives, emphasis is placed on providing the possibility of waiving unnecessary tests and on the continuous evaluation of whether certain tests are needed at all. 2000 FRAME.

Conventions for sign and speech transcription of child bimodal bilingual corpora in ELAN.

PubMed

Chen Pichler, Deborah; Hochgesang, Julie A; Lillo-Martin, Diane; de Quadros, Ronice Müller

2010-01-01

This article extends current methodologies for the linguistic analysis of sign language acquisition to cases of bimodal bilingual acquisition. Using ELAN, we are transcribing longitudinal spontaneous production data from hearing children of Deaf parents who are learning either American Sign Language (ASL) and American English (AE), or Brazilian Sign Language (Libras, also referred to as Língua de Sinais Brasileira/LSB in some texts) and Brazilian Portuguese (BP). Our goal is to construct corpora that can be mined for a wide range of investigations on various topics in acquisition. Thus, it is important that we maintain consistency in transcription for both signed and spoken languages. This article documents our transcription conventions, including the principles behind our approach. Using this document, other researchers can chose to follow similar conventions or develop new ones using our suggestions as a starting point.

Conventions for sign and speech transcription of child bimodal bilingual corpora in ELAN

PubMed Central

Chen Pichler, Deborah; Hochgesang, Julie A.; Lillo-Martin, Diane; de Quadros, Ronice Müller

2011-01-01

This article extends current methodologies for the linguistic analysis of sign language acquisition to cases of bimodal bilingual acquisition. Using ELAN, we are transcribing longitudinal spontaneous production data from hearing children of Deaf parents who are learning either American Sign Language (ASL) and American English (AE), or Brazilian Sign Language (Libras, also referred to as Língua de Sinais Brasileira/LSB in some texts) and Brazilian Portuguese (BP). Our goal is to construct corpora that can be mined for a wide range of investigations on various topics in acquisition. Thus, it is important that we maintain consistency in transcription for both signed and spoken languages. This article documents our transcription conventions, including the principles behind our approach. Using this document, other researchers can chose to follow similar conventions or develop new ones using our suggestions as a starting point. PMID:21625371

ILRS Station Reporting

NASA Technical Reports Server (NTRS)

Noll, Carey E.; Pearlman, Michael Reisman; Torrence, Mark H.

2013-01-01

Network stations provided system configuration documentation upon joining the ILRS. This information, found in the various site and system log files available on the ILRS website, is essential to the ILRS analysis centers, combination centers, and general user community. Therefore, it is imperative that the station personnel inform the ILRS community in a timely fashion when changes to the system occur. This poster provides some information about the various documentation that must be maintained. The ILRS network consists of over fifty global sites actively ranging to over sixty satellites as well as five lunar reflectors. Information about these stations are available on the ILRS website (http://ilrs.gsfc.nasa.gov/network/stations/index.html). The ILRS Analysis Centers must have current information about the stations and their system configuration in order to use their data in generation of derived products. However, not all information available on the ILRS website is as up-to-date as necessary for correct analysis of their data.

Cradle-to-Gate Life-Cycle Inventory of Cellulosic Fiberboard Produced in North America

Treesearch

Richard D. Bergman

2015-01-01

Documenting the environmental performance of building products is becoming widespread because of many green marketing claims made without scientific merit (i.e., green-washing). Developing environmental product declarations (EPDs) for building products is one way to accomplish this objective for scientific documentation and to counter green-washing (ISO 2006a; Bergman...

12 CFR 1101.5 - Testimony and production of documents in response to subpoena, order, etc.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Testimony and production of documents in response to subpoena, order, etc. 1101.5 Section 1101.5 Banks and Banking FEDERAL FINANCIAL INSTITUTIONS EXAMINATION COUNCIL DESCRIPTION OF OFFICE, PROCEDURES, PUBLIC INFORMATION § 1101.5 Testimony and production of...

50 CFR 300.185 - Documentation, reporting and recordkeeping requirements for consignment documents and re-export...

Code of Federal Regulations, 2011 CFR

2011-10-01

.... (3) Reporting requirements. For fish or fish products regulated under this subpart, except shark fins... this paragraph (b) apply to exports of fish or fish products regulated under this subpart, except shark... consignment of fish or fish products regulated under this subpart, except bluefin tuna or shark fins, that was...

15 CFR 15.14 - Demand for testimony or production of documents: Department procedures.

Code of Federal Regulations, 2011 CFR

2011-01-01

... represented by an attorney, to refine or limit a demand so that compliance is less burdensome or obtain... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Demand for testimony or production of....14 Demand for testimony or production of documents: Department procedures. (a) Whenever a demand for...

Earth Observation, Spatial Data Quality, and Neglected Tropical Diseases.

PubMed

Hamm, Nicholas A S; Soares Magalhães, Ricardo J; Clements, Archie C A

2015-12-01

Earth observation (EO) is the use of remote sensing and in situ observations to gather data on the environment. It finds increasing application in the study of environmentally modulated neglected tropical diseases (NTDs). Obtaining and assuring the quality of the relevant spatially and temporally indexed EO data remain challenges. Our objective was to review the Earth observation products currently used in studies of NTD epidemiology and to discuss fundamental issues relating to spatial data quality (SDQ), which limit the utilization of EO and pose challenges for its more effective use. We searched Web of Science and PubMed for studies related to EO and echinococossis, leptospirosis, schistosomiasis, and soil-transmitted helminth infections. Relevant literature was also identified from the bibliographies of those papers. We found that extensive use is made of EO products in the study of NTD epidemiology; however, the quality of these products is usually given little explicit attention. We review key issues in SDQ concerning spatial and temporal scale, uncertainty, and the documentation and use of quality information. We give examples of how these issues may interact with uncertainty in NTD data to affect the output of an epidemiological analysis. We conclude that researchers should give careful attention to SDQ when designing NTD spatial-epidemiological studies. This should be used to inform uncertainty analysis in the epidemiological study. SDQ should be documented and made available to other researchers.

Effects of environmental variation during seed production on seed dormancy and germination.

PubMed

Penfield, Steven; MacGregor, Dana R

2017-02-01

The environment during seed production has major impacts on the behaviour of progeny seeds. It can be shown that for annual plants temperature perception over the whole life history of the mother can affect the germination rate of progeny, and instances have been documented where these affects cross whole generations. Here we discuss the current state of knowledge of signal transduction pathways controlling environmental responses during seed production, focusing both on events that take place in the mother plant and those that occur directly as a result of environmental responses in the developing zygote. We show that seed production environment effects are complex, involving overlapping gene networks active independently in fruit, seed coat, and zygotic tissues that can be deconstructed using careful physiology alongside molecular and genetic experiments. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Bioenergy and Biodiversity: Key Lessons from the Pan American Region

NASA Astrophysics Data System (ADS)

Kline, Keith L.; Martinelli, Fernanda Silva; Mayer, Audrey L.; Medeiros, Rodrigo; Oliveira, Camila Ortolan F.; Sparovek, Gerd; Walter, Arnaldo; Venier, Lisa A.

2015-12-01

Understanding how large-scale bioenergy production can affect biodiversity and ecosystems is important if society is to meet current and future sustainable development goals. A variety of bioenergy production systems have been established within different contexts throughout the Pan American region, with wide-ranging results in terms of documented and projected effects on biodiversity and ecosystems. The Pan American region is home to the majority of commercial bioenergy production and therefore the region offers a broad set of experiences and insights on both conflicts and opportunities for biodiversity and bioenergy. This paper synthesizes lessons learned focusing on experiences in Canada, the United States, and Brazil regarding the conflicts that can arise between bioenergy production and ecological conservation, and benefits that can be derived when bioenergy policies promote planning and more sustainable land-management systems. We propose a research agenda to address priority information gaps that are relevant to biodiversity concerns and related policy challenges in the Pan American region.

Bioenergy and biodiversity: Key lessons from the Pan American region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kline, Keith L.; Martinelli, Fernanda Silva; Mayer, Audrey L.

Understanding how large-scale bioenergy production can affect biodiversity and ecosystems is important if society is to meet current and future sustainable development goals. A variety of bioenergy production systems have been established within different contexts throughout the Pan American region, with wide-ranging results in terms of documented and projected effects on biodiversity and ecosystems. The Pan American region is home to the majority of commercial bioenergy production and therefore the region offers a broad set of experiences and insights on both conflicts and opportunities for biodiversity and bioenergy. This paper synthesizes lessons learned focusing on experiences in Canada, the Unitedmore » States, and Brazil, regarding the conflicts that can arise between bioenergy production and ecological conservation, and benefits that can be derived when bioenergy policies promote planning and more sustainable land management systems. Lastly, we propose a research agenda to address priority information gaps that are relevant to biodiversity concerns and related policy challenges in the Pan American region.« less

The Electronic Documentation Project in the NASA mission control center environment

NASA Technical Reports Server (NTRS)

Wang, Lui; Leigh, Albert

1994-01-01

NASA's space programs like many other technical programs of its magnitude is supported by a large volume of technical documents. These documents are not only diverse but also abundant. Management, maintenance, and retrieval of these documents is a challenging problem by itself; but, relating and cross-referencing this wealth of information when it is all on a medium of paper is an even greater challenge. The Electronic Documentation Project (EDP) is to provide an electronic system capable of developing, distributing and controlling changes for crew/ground controller procedures and related documents. There are two primary motives for the solution. The first motive is to reduce the cost of maintaining the current paper based method of operations by replacing paper documents with electronic information storage and retrieval. And, the other is to improve the efficiency and provide enhanced flexibility in document usage. Initially, the current paper based system will be faithfully reproduced in an electronic format to be used in the document viewing system. In addition, this metaphor will have hypertext extensions. Hypertext features support basic functions such as full text searches, key word searches, data retrieval, and traversal between nodes of information as well as speeding up the data access rate. They enable related but separate documents to have relationships, and allow the user to explore information naturally through non-linear link traversals. The basic operational requirements of the document viewing system are to: provide an electronic corollary to the current method of paper based document usage; supplement and ultimately replace paper-based documents; maintain focused toward control center operations such as Flight Data File, Flight Rules and Console Handbook viewing; and be available NASA wide.

State of the art in gluten-free research.

PubMed

O'Shea, Norah; Arendt, Elke; Gallagher, Eimear

2014-06-01

Celiac disease (CD) is widespread and is often under diagnosed. It can affect a variety of genetically susceptible people from the young to the old. Presently, the only treatment for celiac patients is lifelong avoidance of any food, drink, sauce, or dressing containing gluten. Scientists and technologists continue in their quest to improve the quality of gluten-free products. Their main goal is to create a product of a similar standard to the gluten-containing products, currently on the market. However, the quality of these products still tends to be poor. Bread products have a low volume, pale crust, crumbly texture, bland flavor and a high rate of staling. Other gluten-free products contain minimal nutrition and substandard product characteristics, for example, pasta having an inferior texture, sauces which separate more easily. The main focus of this review is to discuss the most recent advances in gluten-free research which have arisen between the years 2011 and 2013. In particular, the manuscript focuses on ingredients and processing methods which have been documented to develop or improve the processing characteristics and nutritional properties of gluten-free products. © 2014 Institute of Food Technologists®

36 CFR 1194.41 - Information, documentation, and support.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TRANSPORTATION BARRIERS COMPLIANCE BOARD ELECTRONIC AND INFORMATION TECHNOLOGY ACCESSIBILITY STANDARDS Information, Documentation, and Support § 1194.41 Information, documentation, and support. (a) Product support... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Information, documentation...

Personal Care Product Use in Pregnancy and the Postpartum Period: Implications for Exposure Assessment.

PubMed

Lang, Carly; Fisher, Mandy; Neisa, Angelica; MacKinnon, Leona; Kuchta, Sandra; MacPherson, Susan; Probert, Adam; Arbuckle, Tye E

2016-01-06

Concern regarding the potential for developmental health risks associated with certain chemicals (e.g., phthalates, antibacterials) used in personal care products is well documented; however, current exposure data for pregnant women are limited. The objective of this study was to describe the pattern of personal care product use in pregnancy and the post-partum period. Usage patterns of personal care products were collected at six different time points during pregnancy and once in the postpartum period for a cohort of 80 pregnant women in Ottawa, Canada. The pattern of use was then described and groups of personal care product groups commonly used together were identified using hierarchical cluster analysis. The results showed that product use varied by income and country of birth. General hygiene products were the most commonly used products and were consistently used over time while cosmetic product use declined with advancing pregnancy and post-delivery. Hand soaps and baby products were reported as used more frequently after birth. This study is the first to track personal care product use across pregnancy and into the postpartum period, and suggests that pregnant populations may be a unique group of personal care product users. This information will be useful for exposure assessments.

Personal Care Product Use in Pregnancy and the Postpartum Period: Implications for Exposure Assessment

PubMed Central

Lang, Carly; Fisher, Mandy; Neisa, Angelica; MacKinnon, Leona; Kuchta, Sandra; MacPherson, Susan; Probert, Adam; Arbuckle, Tye E.

2016-01-01

Concern regarding the potential for developmental health risks associated with certain chemicals (e.g., phthalates, antibacterials) used in personal care products is well documented; however, current exposure data for pregnant women are limited. The objective of this study was to describe the pattern of personal care product use in pregnancy and the post-partum period. Usage patterns of personal care products were collected at six different time points during pregnancy and once in the postpartum period for a cohort of 80 pregnant women in Ottawa, Canada. The pattern of use was then described and groups of personal care product groups commonly used together were identified using hierarchical cluster analysis. The results showed that product use varied by income and country of birth. General hygiene products were the most commonly used products and were consistently used over time while cosmetic product use declined with advancing pregnancy and post-delivery. Hand soaps and baby products were reported as used more frequently after birth. This study is the first to track personal care product use across pregnancy and into the postpartum period, and suggests that pregnant populations may be a unique group of personal care product users. This information will be useful for exposure assessments. PMID:26751460

Basis and Purpose Document for the proposed NESHAP for Pharmaceuticals Production

EPA Pesticide Factsheets

The Basis and Purpose Document provides background information on, and the rationale for, decisions made by EPA related to the proposed standards for the reduction of hazardous air pollutants (HAP) emitted through the manufacture of pharmaceutical products

39 CFR 955.35 - Subpoenas.

Code of Federal Regulations, 2010 CFR

2010-07-01

... UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE BEFORE THE POSTAL SERVICE BOARD OF CONTRACT...) Production of books and papers. The production by a witness of books, papers, documents, electronically... attendance of desired third-party witnesses, books, papers, documents, or tangible things whenever possible...

46 CFR 201.109 - Discovery and production of documents.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 201.109 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION POLICY, PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Discovery and Depositions (Rule 11) § 201.109 Discovery and production... any designated documents, papers, books, accounts, letters, photographs, objects, or tangible things...

Natural products and the athlete: facts and folklore.

PubMed

Barron, R L; Vanscoy, G J

1993-05-01

To contrast scientific facts with suggested manufacturers' claims regarding food supplements (natural products) marketed for enhanced athletic prowess. A MEDLINE search was performed to obtain documentation supporting the claims of natural-product manufacturers. In addition, several references pertaining to pharmacognosy, natural products, herbs, pharmacy practice, and sports medicine were reviewed. Claims were obtained from promotional advertisements in bodybuilding magazines, product labels, and fact sheets for sales representatives in nutrition and health-food stores. We reviewed all of the clinical trials, published between 1966 and 1992, relative to the manufacturers' claims regarding these products. Pertinent human and/or animal studies supporting each natural product were compared with the manufacturers' claims. We found that there was no published scientific evidence to support the promotional claims for a large proportion of the products (8/19, 42 percent). Only 4 of 19 products (21 percent) were associated with any documented human clinical trials supporting their promotional claims. Six of 19 agents (32 percent) had some scientific documentation to support their promotional claims; however, these products were judged to be marketed in a misleading manner.

The effects of radiofrequency electromagnetic radiation on sperm function.

PubMed

Houston, B J; Nixon, B; King, B V; De Iuliis, G N; Aitken, R J

2016-12-01

Mobile phone usage has become an integral part of our lives. However, the effects of the radiofrequency electromagnetic radiation (RF-EMR) emitted by these devices on biological systems and specifically the reproductive systems are currently under active debate. A fundamental hindrance to the current debate is that there is no clear mechanism of how such non-ionising radiation influences biological systems. Therefore, we explored the documented impacts of RF-EMR on the male reproductive system and considered any common observations that could provide insights on a potential mechanism. Among a total of 27 studies investigating the effects of RF-EMR on the male reproductive system, negative consequences of exposure were reported in 21. Within these 21 studies, 11 of the 15 that investigated sperm motility reported significant declines, 7 of 7 that measured the production of reactive oxygen species (ROS) documented elevated levels and 4 of 5 studies that probed for DNA damage highlighted increased damage due to RF-EMR exposure. Associated with this, RF-EMR treatment reduced the antioxidant levels in 6 of 6 studies that discussed this phenomenon, whereas consequences of RF-EMR were successfully ameliorated with the supplementation of antioxidants in all 3 studies that carried out these experiments. In light of this, we envisage a two-step mechanism whereby RF-EMR is able to induce mitochondrial dysfunction leading to elevated ROS production. A continued focus on research, which aims to shed light on the biological effects of RF-EMR will allow us to test and assess this proposed mechanism in a variety of cell types. © 2016 Society for Reproduction and Fertility.

GeoDeepDive: Towards a Machine Reading-Ready Digital Library and Information Integration Resource

NASA Astrophysics Data System (ADS)

Husson, J. M.; Peters, S. E.; Livny, M.; Ross, I.

2015-12-01

Recent developments in machine reading and learning approaches to text and data mining hold considerable promise for accelerating the pace and quality of literature-based data synthesis, but these advances have outpaced even basic levels of access to the published literature. For many geoscience domains, particularly those based on physical samples and field-based descriptions, this limitation is significant. Here we describe a general infrastructure to support published literature-based machine reading and learning approaches to information integration and knowledge base creation. This infrastructure supports rate-controlled automated fetching of original documents, along with full bibliographic citation metadata, from remote servers, the secure storage of original documents, and the utilization of considerable high-throughput computing resources for the pre-processing of these documents by optical character recognition, natural language parsing, and other document annotation and parsing software tools. New tools and versions of existing tools can be automatically deployed against original documents when they are made available. The products of these tools (text/XML files) are managed by MongoDB and are available for use in data extraction applications. Basic search and discovery functionality is provided by ElasticSearch, which is used to identify documents of potential relevance to a given data extraction task. Relevant files derived from the original documents are then combined into basic starting points for application building; these starting points are kept up-to-date as new relevant documents are incorporated into the digital library. Currently, our digital library stores contains more than 360K documents supplied by Elsevier and the USGS and we are actively seeking additional content providers. By focusing on building a dependable infrastructure to support the retrieval, storage, and pre-processing of published content, we are establishing a foundation for complex, and continually improving, information integration and data extraction applications. We have developed one such application, which we present as an example, and invite new collaborations to develop other such applications.

[Bibliometric analysis of the Spanish scientific production in Infectious Diseases and Microbiology].

PubMed

Ramos, José Manuel; González-Alcaide, Gregorio; Gutiérrez, Félix

2016-03-01

The bibliometric analysis of production and impact of documents by knowledge area is a quantitative and qualitative indicator of research activity in this field. The aim of this article is to determine the contribution of Spanish research institutions in Infectious Diseases and Microbiology in recent years. Documents published in the journals included in the categories "Infectious Diseases" and "Microbiology" of the Web of Science (Science Citation Index Expanded) of the ISI Web of Knowledge from the year 2000-2013 were analysed. In Infectious Diseases, Spain ranked fourth worldwide, and contributed 5.7% of the 233,771 documents published in this specialty. In Microbiology, Spain was in sixth place with a production rate of 5.8% of the 149,269 documents of this category. The Spanish production increased over the study period, both in Infectious Diseases and Microbiology, from 325 and 619 documents in 2000 to 756 and 1245 documents in 2013, with a growth rate of 131% and 45.8%, respectively. The journal with the largest number of documents published was Enfermedades Infecciosas y Microbiología Clínica, with 8.6% and 8.2% of papers published in the categories of Infectious Diseases and Microbiology, respectively, and was the result of international collaborations, especially with institutions in the United States. The "index h" was 116 and 139 in Infectious Diseases and Microbiology, placing Spain in fifth place in both categories within countries of the European Union. In recent years, Spanish research in Infectious Diseases and Microbiology has reached a good level of production and international visibility, reaching a global leadership position. Copyright © 2015. Published by Elsevier España, S.L.U.

Transnational Tobacco Company Interests in Smokeless Tobacco in Europe: Analysis of Internal Industry Documents and Contemporary Industry Materials

PubMed Central

Peeters, Silvy; Gilmore, Anna B.

2013-01-01

Background European Union (EU) legislation bans the sale of snus, a smokeless tobacco (SLT) which is considerably less harmful than smoking, in all EU countries other than Sweden. To inform the current review of this legislation, this paper aims to explore transnational tobacco company (TTC) interests in SLT and pure nicotine in Europe from the 1970s to the present, comparing them with TTCs' public claims of support for harm reduction. Methods and Results Internal tobacco industry documents (in total 416 documents dating from 1971 to 2009), obtained via searching the online Legacy Tobacco Documents Library, were analysed using a hermeneutic approach. This library comprises documents obtained via litigation in the US and does not include documents from Imperial Tobacco, Japan Tobacco International, or Swedish Match. To help overcome this limitation and provide more recent data, we triangulated our documentary findings with contemporary documentation including TTC investor presentations. The analysis demonstrates that British American Tobacco explored SLT opportunities in Europe from 1971 driven by regulatory threats and health concerns, both likely to impact cigarette sales negatively, and the potential to create a new form of tobacco use among those no longer interested in taking up smoking. Young people were a key target. TTCs did not, however, make SLT investments until 2002, a time when EU cigarette volumes started declining, smoke-free legislation was being introduced, and public health became interested in harm reduction. All TTCs have now invested in snus (and recently in pure nicotine), yet both early and recent snus test markets appear to have failed, and little evidence was found in TTCs' corporate materials that snus is central to their business strategy. Conclusions There is clear evidence that BAT's early interest in introducing SLT in Europe was based on the potential for creating an alternative form of tobacco use in light of declining cigarette sales and social restrictions on smoking, with young people a key target. We conclude that by investing in snus, and recently nicotine, TTCs have eliminated competition between cigarettes and lower-risk products, thus helping maintain the current market balance in favour of (highly profitable) cigarettes while ensuring TTCs' long-term future should cigarette sales decline further and profit margins be eroded. Please see later in the article for the Editors' Summary PMID:24058299

Transnational tobacco company interests in smokeless tobacco in Europe: analysis of internal industry documents and contemporary industry materials.

PubMed

Peeters, Silvy; Gilmore, Anna B

2013-01-01

European Union (EU) legislation bans the sale of snus, a smokeless tobacco (SLT) which is considerably less harmful than smoking, in all EU countries other than Sweden. To inform the current review of this legislation, this paper aims to explore transnational tobacco company (TTC) interests in SLT and pure nicotine in Europe from the 1970s to the present, comparing them with TTCs' public claims of support for harm reduction. Internal tobacco industry documents (in total 416 documents dating from 1971 to 2009), obtained via searching the online Legacy Tobacco Documents Library, were analysed using a hermeneutic approach. This library comprises documents obtained via litigation in the US and does not include documents from Imperial Tobacco, Japan Tobacco International, or Swedish Match. To help overcome this limitation and provide more recent data, we triangulated our documentary findings with contemporary documentation including TTC investor presentations. The analysis demonstrates that British American Tobacco explored SLT opportunities in Europe from 1971 driven by regulatory threats and health concerns, both likely to impact cigarette sales negatively, and the potential to create a new form of tobacco use among those no longer interested in taking up smoking. Young people were a key target. TTCs did not, however, make SLT investments until 2002, a time when EU cigarette volumes started declining, smoke-free legislation was being introduced, and public health became interested in harm reduction. All TTCs have now invested in snus (and recently in pure nicotine), yet both early and recent snus test markets appear to have failed, and little evidence was found in TTCs' corporate materials that snus is central to their business strategy. There is clear evidence that BAT's early interest in introducing SLT in Europe was based on the potential for creating an alternative form of tobacco use in light of declining cigarette sales and social restrictions on smoking, with young people a key target. We conclude that by investing in snus, and recently nicotine, TTCs have eliminated competition between cigarettes and lower-risk products, thus helping maintain the current market balance in favour of (highly profitable) cigarettes while ensuring TTCs' long-term future should cigarette sales decline further and profit margins be eroded. Please see later in the article for the Editors' Summary.

78 FR 20604 - Enhanced Document Requirements To Support Use of the Dolphin Safe Label on Tuna Products

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-05

... Commission Act for including a dolphin-safe label on tuna product in the United States that fails to meet the.... 130221153-3153-01] RIN 0648-BC78 Enhanced Document Requirements To Support Use of the Dolphin Safe Label on Tuna Products AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric...

A hypertext system that learns from user feedback

NASA Technical Reports Server (NTRS)

Mathe, Nathalie

1994-01-01

Retrieving specific information from large amounts of documentation is not an easy task. It could be facilitated if information relevant in the current problem solving context could be automatically supplied to the user. As a first step towards this goal, we have developed an intelligent hypertext system called CID (Computer Integrated Documentation). Besides providing an hypertext interface for browsing large documents, the CID system automatically acquires and reuses the context in which previous searches were appropriate. This mechanism utilizes on-line user information requirements and relevance feedback either to reinforce current indexing in case of success or to generate new knowledge in case of failure. Thus, the user continually augments and refines the intelligence of the retrieval system. This allows the CID system to provide helpful responses, based on previous usage of the documentation, and to improve its performance over time. We successfully tested the CID system with users of the Space Station Freedom requirements documents. We are currently extending CID to other application domains (Space Shuttle operations documents, airplane maintenance manuals, and on-line training). We are also exploring the potential commercialization of this technique.

Cigarette users' interest in using or switching to electronic nicotine delivery systems for smokeless tobacco for harm reduction, cessation, or novelty: a cross-sectional survey of US adults.

PubMed

Berg, Carla J; Haardoerfer, Regine; Escoffery, Cam; Zheng, Pinpin; Kegler, Michelle

2015-02-01

We examined: (a) current (past 30-day) smokers' interest in using or switching to electronic nicotine delivery systems (ENDS) or smokeless tobacco for various reasons; (b) correlates of interest in these products; and (c) subgroups of current smokers in relation to interest in these products. We conducted a cross-sectional survey assessing sociodemographics, tobacco use, interest in ENDS and smokeless tobacco among smokers, and knowledge about ENDS among 2,501 US adults recruited through an online consumer panel. We oversampled tobacco users (36.7% current cigarette smokers), ethnic minorities, and southeastern US state residents. On average, participants were more interested in ENDS than smokeless tobacco across all reasons provided. Additionally, they were less interested in either product because of their potential use in places prohibiting smoking or due to curiosity and more interested in reducing health risk or cigarette consumption or to aid in cessation. We documented high rates (27.9%) of misbeliefs about Food and Drug Administration approval of ENDS for cessation, particularly among current smokers (38.5%). Also, 27.2% of current smokers had talked with a health care provider about ENDS, with 18.0% reporting that their provider endorsed ENDS use for cessation. Furthermore, cluster analyses revealed 3 groups distinct in their interest in the products, sociodemographics, and smoking-related characteristics. This study highlights higher interest in ENDS versus smokeless tobacco and greater interest in both for harm reduction and cessation than due to novelty or smoking restrictions. Developing educational campaigns and informing practitioners about caveats around ENDS as cessation or harm reduction aids are critical. © The Author 2014. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

16 CFR 1203.3 - Referenced documents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Referenced documents. 1203.3 Section 1203.3 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY... international standard, it has become a consensus national standard because all recent major voluntary standards...

77 FR 31724 - Production Measurement Documents Incorporated by Reference; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-30

... DEPARTMENT OF THE INTERIOR Bureau of Safety and Environmental Enforcement 30 CFR Part 250 [Docket ID: BSEE-2012-0003] RIN 1014-AA01 Production Measurement Documents Incorporated by Reference; Correction AGENCY: Bureau of Safety and Environmental Enforcement (BSEE), Interior. ACTION: Correcting...

Evidence-based integrated environmental solutions for secondary lead smelters: pollution prevention and waste minimization technologies and practices.

PubMed

Genaidy, A M; Sequeira, R; Tolaymat, T; Kohler, J; Rinder, M

2009-05-01

An evidence-based methodology was adopted in this research to establish strategies to increase lead recovery and recycling via a systematic review and critical appraisal of the published literature. In particular, the research examines pollution prevention and waste minimization practices and technologies that meet the following criteria: (a) reduce/recover/recycle the largest quantities of lead currently being disposed of as waste, (b) technically and economically viable, that is, ready to be diffused and easily transferable, and (c) strong industry interest (i.e., industry would consider implementing projects with higher payback periods). The following specific aims are designed to achieve the study objectives: Aim 1 - To describe the recycling process of recovering refined lead from scrap; Aim 2 - To document pollution prevention and waste management technologies and practices adopted by US stakeholders along the trajectory of LAB and lead product life cycle; Aim 3 - To explore improved practices and technologies which are employed by other organizations with an emphasis on the aforementioned criteria; Aim 4 - To demonstrate the economic and environmental costs and benefits of applying improved technologies and practices to existing US smelting operations; and Aim 5 - To evaluate improved environmental technologies and practices using an algorithm that integrates quantitative and qualitative criteria. The process of identifying relevant articles and reports was documented. The description of evidence was presented for current practices and technologies used by US smelters as well as improved practices and technologies. Options for integrated environmental solutions for secondary smelters were introduced and rank ordered on the basis of costs (i.e., capital investment) and benefits (i.e., production increases, energy and flux savings, and reduction of SO(2) and slag). An example was provided to demonstrate the utility of the algorithm by detailing the costs and benefits associated with different combinations of practices and technologies. The evidence-based methodology documented in this research reveals that it is technically and economically feasible to implement integrated environmental solutions to increase lead recovery and recycling among US smelters. The working example presented in this research can be confirmed with US stakeholders and form the basis for implementable solutions in the lead smelter and product industries to help reverse the overall trend of declining life-cycle recycling rates.

Production data in media systems and press front ends: capture, formats and database methods

NASA Astrophysics Data System (ADS)

Karttunen, Simo

1997-02-01

The nature, purpose and data presentation features of media jobs are analyzed in relation to the content, document, process and resource management in media production. Formats are the natural way of presenting, collecting and storing information, contents, document components and final documents. The state of the art and the trends in the media formats and production data are reviewed. The types and the amount of production data are listed, e.g. events, schedules, product descriptions, reports, visual support, quality, process states and color data. The data exchange must be vendor-neutral. Adequate infrastructure and system architecture are defined for production and media data. The roles of open servers and intranets are evaluated and their potential roles as future solutions are anticipated. The press frontend is the part of print media production where large files dominate. The new output alternatives, i.e. film recorders, direct plate output (CTP and CTP-on-press) and digital, plateless printing lines need new workflow tools and very efficient file and format management. The paper analyzes the capture, formatting and storing of job files and respective production data, such as the event logs of the processes. Intranet, browsers, Java applets and open web severs will be used to capture production data, especially where intranets are used anyhow, or where several companies are networked to plan, design and use documents and printed products. The user aspects of installing intranets is stressed since there are numerous more traditional and more dedicated networking solutions on the market.

Air Quality Criteria for Ozone and Other Photochemical Oxidants (1978)

EPA Science Inventory

This document consolidates and assesses current knowledge regarding the origin of ozone and other photochemical oxidants and discusses their effect on health, vegetation, certain ecosystems, and materials. This document summarizes current data on the effects of oxidant/ozone in t...

Sea-ice induced growth decline in Arctic shrubs.

PubMed

Forchhammer, Mads

2017-08-01

Measures of increased tundra plant productivity have been associated with the accelerating retreat of the Arctic sea-ice. Emerging studies document opposite effects, advocating for a more complex relationship between the shrinking sea-ice and terrestrial plant productivity. I introduce an autoregressive plant growth model integrating effects of biological and climatic conditions for analysing individual ring-width growth time series. Using 128 specimens of Salix arctica , S. glauca and Betula nana sampled across Greenland to Svalbard, an overall negative effect of the retreating June sea-ice extent was found on the annual growth. The negative effect of the retreating June sea-ice was observed for younger individuals with large annual growth allocations and with little or no trade-off between previous and current year's growth. © 2017 The Author(s).

Health Benefits of Probiotics: A Review

PubMed Central

Dimitriadi, Dimitra; Gyftopoulou, Konstantina; Skarmoutsou, Nikoletta

2013-01-01

Probiotic bacteria have become increasingly popular during the last two decades as a result of the continuously expanding scientific evidence pointing to their beneficial effects on human health. As a result they have been applied as various products with the food industry having been very active in studying and promoting them. Within this market the probiotics have been incorporated in various products, mainly fermented dairy foods. In light of this ongoing trend and despite the strong scientific evidence associating these microorganisms to various health benefits, further research is needed in order to establish them and evaluate their safety as well as their nutritional aspects. The purpose of this paper is to review the current documentation on the concept and the possible beneficial properties of probiotic bacteria in the literature, focusing on those available in food. PMID:24959545

File Specification for the 7-km GEOS-5 Nature Run, Ganymed Release Non-Hydrostatic 7-km Global Mesoscale Simulation

NASA Technical Reports Server (NTRS)

da Silva, Arlindo M.; Putman, William; Nattala, J.

2014-01-01

This document describes the gridded output files produced by a two-year global, non-hydrostatic mesoscale simulation for the period 2005-2006 produced with the non-hydrostatic version of GEOS-5 Atmospheric Global Climate Model (AGCM). In addition to standard meteorological parameters (wind, temperature, moisture, surface pressure), this simulation includes 15 aerosol tracers (dust, sea-salt, sulfate, black and organic carbon), O3, CO and CO2. This model simulation is driven by prescribed sea-surface temperature and sea-ice, daily volcanic and biomass burning emissions, as well as high-resolution inventories of anthropogenic sources. A description of the GEOS-5 model configuration used for this simulation can be found in Putman et al. (2014). The simulation is performed at a horizontal resolution of 7 km using a cubed-sphere horizontal grid with 72 vertical levels, extending up to to 0.01 hPa (approximately 80 km). For user convenience, all data products are generated on two logically rectangular longitude-latitude grids: a full-resolution 0.0625 deg grid that approximately matches the native cubed-sphere resolution, and another 0.5 deg reduced-resolution grid. The majority of the full-resolution data products are instantaneous with some fields being time-averaged. The reduced-resolution datasets are mostly time-averaged, with some fields being instantaneous. Hourly data intervals are used for the reduced-resolution datasets, while 30-minute intervals are used for the full-resolution products. All full-resolution output is on the model's native 72-layer hybrid sigma-pressure vertical grid, while the reduced-resolution output is given on native vertical levels and on 48 pressure surfaces extending up to 0.02 hPa. Section 4 presents additional details on horizontal and vertical grids. Information of the model surface representation can be found in Appendix B. The GEOS-5 product is organized into file collections that are described in detail in Appendix C. Additional details about variables listed in this file specification can be found in a separate document, the GEOS-5 File Specification Variable Definition Glossary. Documentation about the current access methods for products described in this document can be found on the GEOS-5 Nature Run portal: http://gmao.gsfc.nasa.gov/projects/G5NR. Information on the scientific quality of this simulation will appear in a forthcoming NASA Technical Report Series on Global Modeling and Data Assimilation to be available from http://gmao.gsfc.nasa.gov/pubs/tm/.

U.S. Geological Survey Fundamental Science Practices

USGS Publications Warehouse

,

2011-01-01

The USGS has a long and proud tradition of objective, unbiased science in service to the Nation. A reputation for impartiality and excellence is one of our most important assets. To help preserve this vital asset, in 2004 the Executive Leadership Team (ELT) of the USGS was charged by the Director to develop a set of fundamental science practices, philosophical premises, and operational principles as the foundation for all USGS research and monitoring activities. In a concept document, 'Fundamental Science Practices of the U.S. Geological Survey', the ELT proposed 'a set of fundamental principles to underlie USGS science practices.' The document noted that protecting the reputation of USGS science for quality and objectivity requires the following key elements: - Clearly articulated, Bureau-wide fundamental science practices. - A shared understanding at all levels of the organization that the health and future of the USGS depend on following these practices. - The investment of budget, time, and people to ensure that the USGS reputation and high-quality standards are maintained. The USGS Fundamental Science Practices (FSP) encompass all elements of research investigations, including data collection, experimentation, analysis, writing results, peer review, management review, and Bureau approval and publication of information products. The focus of FSP is on how science is carried out and how products are produced and disseminated. FSP is not designed to address the question of what work the USGS should do; that is addressed in USGS science planning handbooks and other documents. Building from longstanding existing USGS policies and the ELT concept document, in May 2006, FSP policies were developed with input from all parts of the organization and were subsequently incorporated into the Bureau's Survey Manual. In developing an implementation plan for FSP policy, the intent was to recognize and incorporate the best of USGS current practices to obtain the optimum overall program for our science. In January 2009, the USGS moved to full implementation of FSP. The FSP Advisory Committee (FSPAC) was formed to serve as the Bureau's working and standing committee to ensure the objectivity and quality of the Bureau's science information products and to provide support for the full implementation of FSP.

Intelligent Agents and Their Potential for Future Design and Synthesis Environment

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler); Malone, John B. (Compiler)

1999-01-01

This document contains the proceedings of the Workshop on Intelligent Agents and Their Potential for Future Design and Synthesis Environment, held at NASA Langley Research Center, Hampton, VA, September 16-17, 1998. The workshop was jointly sponsored by the University of Virginia's Center for Advanced Computational Technology and NASA. Workshop attendees came from NASA, industry and universities. The objectives of the workshop were to assess the status of intelligent agents technology and to identify the potential of software agents for use in future design and synthesis environment. The presentations covered the current status of agent technology and several applications of intelligent software agents. Certain materials and products are identified in this publication in order to specify adequately the materials and products that were investigated in the research effort. In no case does such identification imply recommendation or endorsement of products by NASA, nor does it imply that the materials and products are the only ones or the best ones available for this purpose. In many cases equivalent materials and products are available and would probably produce equivalent results.

Increasing Sales by Developing Production Consortiums.

ERIC Educational Resources Information Center

Smith, Christopher A.; Russo, Robert

Intended to help rehabilitation facility administrators increase organizational income from manufacturing and/or contracted service sources, this document provides a decision-making model for the development of a production consortium. The document consists of five chapters and two appendices. Chapter 1 defines the consortium concept, explains…

Repository-based software engineering program: Concept document

NASA Technical Reports Server (NTRS)

1992-01-01

This document provides the context for Repository-Based Software Engineering's (RBSE's) evolving functional and operational product requirements, and it is the parent document for development of detailed technical and management plans. When furnished, requirements documents will serve as the governing RBSE product specification. The RBSE Program Management Plan will define resources, schedules, and technical and organizational approaches to fulfilling the goals and objectives of this concept. The purpose of this document is to provide a concise overview of RBSE, describe the rationale for the RBSE Program, and define a clear, common vision for RBSE team members and customers. The document also provides the foundation for developing RBSE user and system requirements and a corresponding Program Management Plan. The concept is used to express the program mission to RBSE users and managers and to provide an exhibit for community review.

Guidelines for the Design and Conduct of Clinical Studies in Knee Articular Cartilage Repair

PubMed Central

Mithoefer, Kai; Saris, Daniel B.F.; Farr, Jack; Kon, Elizaveta; Zaslav, Kenneth; Cole, Brian J.; Ranstam, Jonas; Yao, Jian; Shive, Matthew; Levine, David; Dalemans, Wilfried; Brittberg, Mats

2011-01-01

Objective: To summarize current clinical research practice and develop methodological standards for objective scientific evaluation of knee cartilage repair procedures and products. Design: A comprehensive literature review was performed of high-level original studies providing information relevant for the design of clinical studies on articular cartilage repair in the knee. Analysis of cartilage repair publications and synopses of ongoing trials were used to identify important criteria for the design, reporting, and interpretation of studies in this field. Results: Current literature reflects the methodological limitations of the scientific evidence available for articular cartilage repair. However, clinical trial databases of ongoing trials document a trend suggesting improved study designs and clinical evaluation methodology. Based on the current scientific information and standards of clinical care, detailed methodological recommendations were developed for the statistical study design, patient recruitment, control group considerations, study endpoint definition, documentation of results, use of validated patient-reported outcome instruments, and inclusion and exclusion criteria for the design and conduct of scientifically sound cartilage repair study protocols. A consensus statement among the International Cartilage Repair Society (ICRS) and contributing authors experienced in clinical trial design and implementation was achieved. Conclusions: High-quality clinical research methodology is critical for the optimal evaluation of current and new cartilage repair technologies. In addition to generally applicable principles for orthopedic study design, specific criteria and considerations apply to cartilage repair studies. Systematic application of these criteria and considerations can facilitate study designs that are scientifically rigorous, ethical, practical, and appropriate for the question(s) being addressed in any given cartilage repair research project. PMID:26069574

[Information production by scientists and the history of science: typological study of personal archives].

PubMed

Silva, Maria Celina Soares de Mello E; Trancoso, Márcia Cristina Duarte

2015-01-01

This article addresses the study of document typology in the personal archives of scientists and its importance in the history of science studies and for the archivist's work. A brief history is presented of diplomatic to typological information, emphasizing that identifying document production activity as essential for its classification. The article illustrates personal archive characteristics as regards the diversity of documental types and, in particular, those belonging to physicists. Furthermore, it presents five examples of documental types found in the archives of physicists as examples of research in progress. It also highlights the elaboration of a glossary of different documental kinds and types found in the private archives of Museum of Astronomy and Related Sciences in Rio de Janeiro.

Facilitating access to information in large documents with an intelligent hypertext system

NASA Technical Reports Server (NTRS)

Mathe, Nathalie

1993-01-01

Retrieving specific information from large amounts of documentation is not an easy task. It could be facilitated if information relevant in the current problem solving context could be automatically supplied to the user. As a first step towards this goal, we have developed an intelligent hypertext system called CID (Computer Integrated Documentation) and tested it on the Space Station Freedom requirement documents. The CID system enables integration of various technical documents in a hypertext framework and includes an intelligent context-sensitive indexing and retrieval mechanism. This mechanism utilizes on-line user information requirements and relevance feedback either to reinforce current indexing in case of success or to generate new knowledge in case of failure. This allows the CID system to provide helpful responses, based on previous usage of the documentation, and to improve its performance over time.

Improving the Quality of Electronic Documentation in Critical Care Nursing

ERIC Educational Resources Information Center

Stevens, Brent

2017-01-01

Electronic nursing documentation systems can facilitate complete, accurate, timely documentation practices, but without effective policies and procedures in place, a gap in practice exists and quality of care may be impacted. This systematic review of literature examined current evidence regarding electronic nursing documentation quality. General…

Efficacy testing of cosmetic products. A proposal to the European Community by the Danish Environmental Protection Agency, Ministry of Environment and Energy.

PubMed

Serup, J

2001-08-01

Regulations for cosmetic products primarily address safety of the products that may be used by large populations of healthy consumers. Requirements for documentation of efficacy claims are only fragmentary. This synopsis aims to review and conclude a set of standards that may be acceptable to the European Community, and the cosmetic industry, as a legal standard for efficacy documentation in Europe in the future. Ethical, formal, experimental, statistical and other aspects of efficacy testing are described, including validation, quality control and assurance. The importance of user relevant clinical end points, a controlled randomized trial design and evidence-based cosmetic product documentation, validation of methods, statistical power estimation and proper data handling, reporting and archiving is emphasized. The main principles of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) good clinical practice (GCP) should be followed by the cosmetics industry in a spirit of good documentation standard and scientific soundness, but full GCP is not considered mandatory in the field of cosmetics. Documentation by validated bio-instrumental methods may be acceptable, but efficacy documentation based on information about raw materials, reference to literature and laboratory experiments are only acceptable in exceptional cases. Principles for efficacy substantiation of cosmetic products in Europe, as described in this synopsis, are officially proposed by the Danish Ministry of Environment and Energy to the European Community as a basis for an amendment to the Cosmetics Directive or otherwise implemented as a European Community regulation.

27 CFR 479.142 - Stolen or lost documents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2011-04-01 2010-04-01 true Stolen or lost documents. 479.142 Section 479.142 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND...

27 CFR 479.142 - Stolen or lost documents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Stolen or lost documents. 479.142 Section 479.142 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND...

27 CFR 479.142 - Stolen or lost documents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Stolen or lost documents. 479.142 Section 479.142 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND...

27 CFR 479.142 - Stolen or lost documents.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2012-04-01 2010-04-01 true Stolen or lost documents. 479.142 Section 479.142 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND...

27 CFR 479.142 - Stolen or lost documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Stolen or lost documents. 479.142 Section 479.142 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND...

15 CFR 904.244 - Production of documents and inspection.

Code of Federal Regulations, 2011 CFR

2011-01-01

... (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS CIVIL PROCEDURES Hearing and Appeal Procedures Discovery § 904.244 Production of documents and inspection. (a... the request is served. (b) Procedure. The request must set forth: (1) The items to be produced or...

15 CFR 904.244 - Production of documents and inspection.

Code of Federal Regulations, 2010 CFR

2010-01-01

... (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS CIVIL PROCEDURES Hearing and Appeal Procedures Discovery § 904.244 Production of documents and inspection. (a... the request is served. (b) Procedure. The request must set forth: (1) The items to be produced or...

29 CFR 2700.60 - Subpoenas.

Code of Federal Regulations, 2010 CFR

2010-07-01

... § 2700.60 Subpoenas. (a) Compulsory attendance of witnesses and production of documents. The Commission and its Judges are authorized to issue subpoenas, on their own motion or on the oral or written application of a party, requiring the attendance of witnesses and the production of documents or physical...

Illinois Occupational Skill Standards. Beef Production Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

This document, which is intended as a guide for workforce preparation program providers, details the Illinois occupational skill standards for programs preparing students for employment in occupations in the beef production cluster. The document begins with a brief overview of the Illinois perspective on occupational skill standards and…

The International Satellite Cloud Climatology Project H-Series climate data record product

NASA Astrophysics Data System (ADS)

Young, Alisa H.; Knapp, Kenneth R.; Inamdar, Anand; Hankins, William; Rossow, William B.

2018-03-01

This paper describes the new global long-term International Satellite Cloud Climatology Project (ISCCP) H-series climate data record (CDR). The H-series data contain a suite of level 2 and 3 products for monitoring the distribution and variation of cloud and surface properties to better understand the effects of clouds on climate, the radiation budget, and the global hydrologic cycle. This product is currently available for public use and is derived from both geostationary and polar-orbiting satellite imaging radiometers with common visible and infrared (IR) channels. The H-series data currently span July 1983 to December 2009 with plans for continued production to extend the record to the present with regular updates. The H-series data are the longest combined geostationary and polar orbiter satellite-based CDR of cloud properties. Access to the data is provided in network common data form (netCDF) and archived by NOAA's National Centers for Environmental Information (NCEI) under the satellite Climate Data Record Program (https://doi.org/10.7289/V5QZ281S). The basic characteristics, history, and evolution of the dataset are presented herein with particular emphasis on and discussion of product changes between the H-series and the widely used predecessor D-series product which also spans from July 1983 through December 2009. Key refinements included in the ISCCP H-series CDR are based on improved quality control measures, modified ancillary inputs, higher spatial resolution input and output products, calibration refinements, and updated documentation and metadata to bring the H-series product into compliance with existing standards for climate data records.

The standardization of terminology of lower urinary tract function in children and adolescents: update report from the Standardization Committee of the International Children's Continence Society.

PubMed

Austin, Paul F; Bauer, Stuart B; Bower, Wendy; Chase, Janet; Franco, Israel; Hoebeke, Piet; Rittig, Søren; Vande Walle, Johan; von Gontard, Alexander; Wright, Anne; Yang, Stephen S; Nevéus, Tryggve

2014-06-01

The impact of the original International Children's Continence Society terminology document on lower urinary tract function resulted in the global establishment of uniformity and clarity in the characterization of lower urinary tract function and dysfunction in children across multiple health care disciplines. The present document serves as a stand-alone terminology update reflecting refinement and current advancement of knowledge on pediatric lower urinary tract function. A variety of worldwide experts from multiple disciplines in the ICCS leadership who care for children with lower urinary tract dysfunction were assembled as part of the standardization committee. A critical review of the previous ICCS terminology document and the current literature was performed. In addition, contributions and feedback from the multidisciplinary ICCS membership were solicited. Following a review of the literature during the last 7 years the ICCS experts assembled a new terminology document reflecting the current understanding of bladder function and lower urinary tract dysfunction in children using resources from the literature review, expert opinion and ICCS member feedback. The present ICCS terminology document provides a current and consensus update to the evolving terminology and understanding of lower urinary tract function in children. For the complete document visit http://jurology.com/. Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Complementary and alternative medical therapies for attention-deficit/hyperactivity disorder and autism.

PubMed

Weber, Wendy; Newmark, Sanford

2007-12-01

Complementary and alternative medical (CAM) therapies are commonly used by parents for their children who have attention deficit hyperactivity disorder (ADHD) or autism spectrum disorders. The use of these therapies is well documented, yet the evidence of the safety and efficacy of these treatments in children is limited. This article describes the current evidence-based CAM therapies for ADHD and autism, focusing on nutritional interventions; natural health products, including essential fatty acids, vitamins, minerals, and other health supplements; biofeedback; and reducing environmental toxins. The CAM evidence in ADHD is addressed, as is the CAM literature in autism.

Vision 2030. A Vision for the U.S. Concrete Industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2001-01-01

On September 27, 2000, the concrete industry's Strategic Development Council hosted a Concrete Vision Workshop in Chicago, Illinois. Meeting participants included over 50 concrete, cement, and other allied industry chief executive officers, presidents, vice-presidents, laboratory and industry research managers, and government representatives. Participants discussed the state of the concrete industry 30 years ago, the state of the current industry, and their vision for the United States concrete industry in 2030. Moreover, they identified specific goals to achieve the industry's Vision 2030. This document, Vision 2030, is the product of that workshop and the comments received after a broad industry review.

SAGA: A project to automate the management of software production systems

NASA Technical Reports Server (NTRS)

Campbell, R. H.

1983-01-01

The current work in progress for the SAGA project are described. The highlights of this research are: a parser independent SAGA editor, design for the screen editing facilities of the editor, delivery to NASA of release 1 of Olorin, the SAGA parser generator, personal workstation environment research, release 1 of the SAGA symbol table manager, delta generation in SAGA, requirements for a proof management system, documentation for and testing of the cyber pascal make prototype, a prototype cyber-based slicing facility, a June 1984 demonstration plan, SAGA utility programs, summary of UNIX software engineering support, and theorem prover review.

Development, Problems and Countermeasures of Chinese Racing Car Industry

NASA Astrophysics Data System (ADS)

Yang, J. J.

2018-05-01

In recent years, motor car racing has developed rapidly in China. However, under the background of maximum vehicle production and car ownership in China, the racing car industry has a long way compared with that of the developed countries. The paper analyzes the current situation and summarizes the problems of Chinese racing car industry with supporting documentation and review of the literature. The future trend of the development of car industry in China is discussed. On the basis of the analysis and prediction, the strategies to respond to the future racing car industry in China are presented.

Advanced flight computer. Special study

NASA Technical Reports Server (NTRS)

Coo, Dennis

1995-01-01

This report documents a special study to define a 32-bit radiation hardened, SEU tolerant flight computer architecture, and to investigate current or near-term technologies and development efforts that contribute to the Advanced Flight Computer (AFC) design and development. An AFC processing node architecture is defined. Each node may consist of a multi-chip processor as needed. The modular, building block approach uses VLSI technology and packaging methods that demonstrate a feasible AFC module in 1998 that meets that AFC goals. The defined architecture and approach demonstrate a clear low-risk, low-cost path to the 1998 production goal, with intermediate prototypes in 1996.

Development of a prototype interactive learning system using multi-media technology for mission independent training program

NASA Technical Reports Server (NTRS)

Matson, Jack E.

1992-01-01

The Spacelab Mission Independent Training Program provides an overview of payload operations. Most of the training material is currently presented in workbook form with some lecture sessions to supplement selected topics. The goal of this project was to develop a prototype interactive learning system for one of the Mission Independent Training topics to demonstrate how the learning process can be improved by incorporating multi-media technology into an interactive system. This report documents the development process and some of the problems encountered during the analysis, design, and production phases of this system.

Integrating smart roadside initiative into the V2I component of the connected vehicle program : task 3.2.

DOT National Transportation Integrated Search

2015-01-01

This document details an analysis that maps the current Connected Vehicle development effort to the SRI efforts currently underway. The document provides a mapping of how SRI incorporates into the Connected Vehicle program. This mapping is performed ...

12 CFR 911.1 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... obtained by the Finance Board in connection with the performance of official duties, whether the information or documents are in the possession of the Finance Board, a current or former Finance Board...; and information and documents created or obtained by, or in the memory of, a current or former Finance...

12 CFR 911.1 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... obtained by the Finance Board in connection with the performance of official duties, whether the information or documents are in the possession of the Finance Board, a current or former Finance Board...; and information and documents created or obtained by, or in the memory of, a current or former Finance...

Alternative Fuels Data Center

Science.gov Websites

Biodiesel-Blended Diesel Documentation Requirement A person that sells or transfers a title to a biomass-based diesel or biodiesel blend for resale purposes must document the transfer. The document may amount of biomass-based diesel contained in the product. The transfer document must be kept for a period

40 CFR 2.406 - Requests for authenticated copies of EPA documents.

Code of Federal Regulations, 2010 CFR

2010-07-01

... EPA documents. 2.406 Section 2.406 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PUBLIC INFORMATION Testimony by Employees and Production of Documents in Civil Legal Proceedings Where the United States Is Not a Party § 2.406 Requests for authenticated copies of EPA documents. Requests...

Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards Antidiabetic Drug Development.

PubMed

Alam, Fahmida; Islam, Md Asiful; Kamal, M A; Gan, Siew Hua

2016-08-13

Over the years, natural products have shown success as antidiabetics in vitro, in vivo and in clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discovery of new antidiabetic drugs from natural products targeting pathways or components associated with type 2 diabetes mellitus (T2DM) pathophysiology. However, the drug discovery process is very lengthy and costly with significant challenges. Therefore, various techniques are currently being developed for the preclinical research phase of drug discovery with the aim of drug development with less time and efforts from natural products. In this review, we have provided an update on natural products including fruits, vegetables, spices, nuts, beverages and mushrooms with potential antidiabetic activities from in vivo, in vitro and clinical studies. Synergistic interactions between natural products and antidiabetic drugs; and potential antidiabetic active compounds from natural products are also documented to pave the way for combination treatment and new drug discovery, respectively. Additionally, a brief idea of the drug discovery process along with the challenges that arise during drug development from natural products and the methods to conquer those challenges are discussed to create a more convenient future drug discovery process.

40 CFR 80.1503 - What are the product transfer document requirements for gasoline-ethanol blends, gasolines, and...

Code of Federal Regulations, 2013 CFR

2013-07-01

... requirements for gasoline-ethanol blends, gasolines, and conventional blendstocks for oxygenate blending... Gasoline-Ethanol Blends § 80.1503 What are the product transfer document requirements for gasoline-ethanol blends, gasolines, and conventional blendstocks for oxygenate blending subject to this subpart? (a...

40 CFR 80.1503 - What are the product transfer document requirements for gasoline-ethanol blends, gasolines, and...

Code of Federal Regulations, 2014 CFR

2014-07-01

... requirements for gasoline-ethanol blends, gasolines, and conventional blendstocks for oxygenate blending... Gasoline-Ethanol Blends § 80.1503 What are the product transfer document requirements for gasoline-ethanol blends, gasolines, and conventional blendstocks for oxygenate blending subject to this subpart? (a...

40 CFR 80.1503 - What are the product transfer document requirements for gasoline-ethanol blends, gasolines, and...

Code of Federal Regulations, 2012 CFR

2012-07-01

... requirements for gasoline-ethanol blends, gasolines, and conventional blendstocks for oxygenate blending... Gasoline-Ethanol Blends § 80.1503 What are the product transfer document requirements for gasoline-ethanol blends, gasolines, and conventional blendstocks for oxygenate blending subject to this subpart? (a...

27 CFR 40.63 - Corporate documents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Corporate documents. 40.63... PROCESSED TOBACCO Qualification Requirements for Manufacturers of Tobacco Products § 40.63 Corporate... furnish with its application for permit, required by § 40.62, a true copy of the corporate charter or a...

27 CFR 40.63 - Corporate documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Corporate documents. 40.63... PROCESSED TOBACCO Qualification Requirements for Manufacturers of Tobacco Products § 40.63 Corporate... furnish with its application for permit, required by § 40.62, a true copy of the corporate charter or a...

27 CFR 40.63 - Corporate documents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Corporate documents. 40.63... PROCESSED TOBACCO Qualification Requirements for Manufacturers of Tobacco Products § 40.63 Corporate... furnish with its application for permit, required by § 40.62, a true copy of the corporate charter or a...

27 CFR 40.63 - Corporate documents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Corporate documents. 40.63... PROCESSED TOBACCO Qualification Requirements for Manufacturers of Tobacco Products § 40.63 Corporate... furnish with its application for permit, required by § 40.62, a true copy of the corporate charter or a...

27 CFR 40.63 - Corporate documents.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Corporate documents. 40.63... PROCESSED TOBACCO Qualification Requirements for Manufacturers of Tobacco Products § 40.63 Corporate... furnish with its application for permit, required by § 40.62, a true copy of the corporate charter or a...

EU Employment and Social Policy, 1999-2001: Jobs, Cohesion, Productivity.

ERIC Educational Resources Information Center

Commission of the European Communities, Brussels (Belgium). Directorate-General for Employment and Social Affairs.

This document examines employment and social policy in the European Union in 1999-2001. The document begins with an interview with Anna Diamantopoulou, the European Union's commissioner for employment and social affairs and the paper "Balancing Jobs, Cohesion, and Productivity" by Odile Quintin, the European Union's director-general for…

10 CFR 215.4 - Production of contracts and documents.

Code of Federal Regulations, 2011 CFR

2011-01-01

... function of the Administrator, he may require the production by any person of any agreement or document relating to foreign oil supply arrangements or reports related thereto. Such material shall be provided pursuant to the conditions prescribed by the Administrator at the time of such order or subsequently. As...

10 CFR 215.4 - Production of contracts and documents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... function of the Administrator, he may require the production by any person of any agreement or document relating to foreign oil supply arrangements or reports related thereto. Such material shall be provided pursuant to the conditions prescribed by the Administrator at the time of such order or subsequently. As...

A Framework for the Generation and Dissemination of Drop Size Distribution (DSD) Characteristics Using Multiple Platforms

NASA Technical Reports Server (NTRS)

Wolf, David B.; Tokay, Ali; Petersen, Walt; Williams, Christopher; Gatlin, Patrick; Wingo, Mathew

2010-01-01

Proper characterization of the precipitation drop size distribution (DSD) is integral to providing realistic and accurate space- and ground-based precipitation retrievals. Current technology allows for the development of DSD products from a variety of platforms, including disdrometers, vertical profilers and dual-polarization radars. Up to now, however, the dissemination or availability of such products has been limited to individual sites and/or field campaigns, in a variety of formats, often using inconsistent algorithms for computing the integral DSD parameters, such as the median- and mass-weighted drop diameter, total number concentration, liquid water content, rain rate, etc. We propose to develop a framework for the generation and dissemination of DSD characteristic products using a unified structure, capable of handling the myriad collection of disdrometers, profilers, and dual-polarization radar data currently available and to be collected during several upcoming GPM Ground Validation field campaigns. This DSD super-structure paradigm is an adaptation of the radar super-structure developed for NASA s Radar Software Library (RSL) and RSL_in_IDL. The goal is to provide the DSD products in a well-documented format, most likely NetCDF, along with tools to ingest and analyze the products. In so doing, we can develop a robust archive of DSD products from multiple sites and platforms, which should greatly benefit the development and validation of precipitation retrieval algorithms for GPM and other precipitation missions. An outline of this proposed framework will be provided as well as a discussion of the algorithms used to calculate the DSD parameters.

17 CFR 232.105 - Limitation on use of HTML documents and hypertext links.

Code of Federal Regulations, 2014 CFR

2014-04-01

... submit the following documents in ASCII: Form N-SAR (§ 274.101 of this chapter) and Form 13F (§ 249.325... exhibits to Form N-SAR in HTML. (b) Electronic filers may not include in any HTML document hypertext links... documents within the current submission and to documents previously filed electronically and located in the...

17 CFR 232.105 - Limitation on use of HTML documents and hypertext links.

Code of Federal Regulations, 2013 CFR

2013-04-01

... submit the following documents in ASCII: Form N-SAR (§ 274.101 of this chapter) and Form 13F (§ 249.325... exhibits to Form N-SAR in HTML. (b) Electronic filers may not include in any HTML document hypertext links... documents within the current submission and to documents previously filed electronically and located in the...

17 CFR 232.105 - Limitation on use of HTML documents and hypertext links.

Code of Federal Regulations, 2011 CFR

2011-04-01

... submit the following documents in ASCII: Form N-SAR (§ 274.101 of this chapter) and Form 13F (§ 249.325... exhibits to Form N-SAR in HTML. (b) Electronic filers may not include in any HTML document hypertext links... documents within the current submission and to documents previously filed electronically and located in the...

17 CFR 232.105 - Limitation on use of HTML documents and hypertext links.

Code of Federal Regulations, 2012 CFR

2012-04-01

... submit the following documents in ASCII: Form N-SAR (§ 274.101 of this chapter) and Form 13F (§ 249.325... exhibits to Form N-SAR in HTML. (b) Electronic filers may not include in any HTML document hypertext links... documents within the current submission and to documents previously filed electronically and located in the...

Carbon Calculator for Land Use Change from Biofuels Production (CCLUB). Users' Manual and Technical Documentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dunn, Jennifer B.; Qin, Zhangcai; Mueller, Steffen

The Carbon Calculator for Land Use Change from Biofuels Production (CCLUB) calculates carbon emissions from land use change (LUC) for four different ethanol production pathways including corn grain ethanol and cellulosic ethanol from corn stover, Miscanthus, and switchgrass. This document discusses the version of CCLUB released September 30, 2014 which includes corn and three cellulosic feedstocks: corn stover, Miscanthus, and switchgrass.

Space Communication Artificial Intelligence for Link Evaluation Terminal (SCAILET)

NASA Technical Reports Server (NTRS)

Shahidi, Anoosh K.; Schlegelmilch, Richard F.; Petrik, Edward J.; Walters, Jerry L.

1992-01-01

A software application to assist end-users of the high burst rate (HBR) link evaluation terminal (LET) for satellite communications is being developed. The HBR LET system developed at NASA Lewis Research Center is an element of the Advanced Communications Technology Satellite (ACTS) Project. The HBR LET is divided into seven major subsystems, each with its own expert. Programming scripts, test procedures defined by design engineers, set up the HBR LET system. These programming scripts are cryptic, hard to maintain and require a steep learning curve. These scripts were developed by the system engineers who will not be available for the end-users of the system. To increase end-user productivity a friendly interface needs to be added to the system. One possible solution is to provide the user with adequate documentation to perform the needed tasks. With the complexity of this system the vast amount of documentation needed would be overwhelming and the information would be hard to retrieve. With limited resources, maintenance is another reason for not using this form of documentation. An advanced form of interaction is being explored using current computer techniques. This application, which incorporates a combination of multimedia and artificial intelligence (AI) techniques to provided end-users with an intelligent interface to the HBR LET system, is comprised of an intelligent assistant, intelligent tutoring, and hypermedia documentation. The intelligent assistant and tutoring systems address the critical programming needs of the end-user.

NCPP's Use of Standard Metadata to Promote Open and Transparent Climate Modeling

NASA Astrophysics Data System (ADS)

Treshansky, A.; Barsugli, J. J.; Guentchev, G.; Rood, R. B.; DeLuca, C.

2012-12-01

The National Climate Predictions and Projections (NCPP) Platform is developing comprehensive regional and local information about the evolving climate to inform decision making and adaptation planning. This includes both creating and providing tools to create metadata about the models and processes used to create its derived data products. NCPP is using the Common Information Model (CIM), an ontology developed by a broad set of international partners in climate research, as its metadata language. This use of a standard ensures interoperability within the climate community as well as permitting access to the ecosystem of tools and services emerging alongside the CIM. The CIM itself is divided into a general-purpose (UML & XML) schema which structures metadata documents, and a project or community-specific (XML) Controlled Vocabulary (CV) which constraints the content of metadata documents. NCPP has already modified the CIM Schema to accommodate downscaling models, simulations, and experiments. NCPP is currently developing a CV for use by the downscaling community. Incorporating downscaling into the CIM will lead to several benefits: easy access to the existing CIM Documents describing CMIP5 models and simulations that are being downscaled, access to software tools that have been developed in order to search, manipulate, and visualize CIM metadata, and coordination with national and international efforts such as ES-DOC that are working to make climate model descriptions and datasets interoperable. Providing detailed metadata descriptions which include the full provenance of derived data products will contribute to making that data (and, the models and processes which generated that data) more open and transparent to the user community.

Feasibility of hospital-initiated non-facilitator assisted advance care planning documentation for patients with palliative care needs.

PubMed

Kok, Maaike; van der Werff, Gertruud F M; Geerling, Jenske I; Ruivenkamp, Jaap; Groothoff, Wies; van der Velden, Annette W G; Thoma, Monique; Talsma, Jaap; Costongs, Louk G P; Gans, Reinold O B; de Graeff, Pauline; Reyners, Anna K L

2018-05-24

Advance Care Planning (ACP) and its documentation, accessible to healthcare professionals regardless of where patients are staying, can improve palliative care. ACP is usually performed by trained facilitators. However, ACP conversations would be more tailored to a patient's specific situation if held by a patient's clinical healthcare team. This study assesses the feasibility of ACP by a patient's clinical healthcare team, and analyses the documented information including current and future problems within the palliative care domains. This multicentre study was conducted at the three Groningen Palliative Care Network hospitals in the Netherlands. Patients discharged from hospital with a terminal care indication received an ACP document from clinical staff (non-palliative care trained staff at hospitals I and II; specialist palliative care nurses at hospital III) after they had held ACP conversations. An anonymised copy of this ACP document was analysed. Documentation rates of patient and contact details were investigated, and documentation of current and future problems were analysed both quantitatively and qualitatively. One hundred sixty ACP documents were received between April 2013 and December 2014, with numbers increasing for each consecutive 3-month time period. Advance directives were frequently documented (82%). Documentation rates of current problems in the social (24%), psychological (27%) and spiritual (16%) domains were low compared to physical problems (85%) at hospital I and II, but consistently high (> 85%) at hospital III. Of 545 documented anticipated problems, 92% were physical or care related in nature, 2% social, 5% psychological, and < 1% spiritual. Half of the anticipated non-physical problems originated from hospital III. Hospital-initiated ACP documentation by a patient's clinical healthcare team is feasible: the number of documents received per time period increased throughout the study period, and overall, documentation rates were high. Nonetheless, symptom documentation predominantly regards physical symptoms. With the involvement of specialist palliative care nurses, psychological and spiritual problems are addressed more frequently. Whether palliative care education for non-palliative care experts will improve identification and documentation of non-physical problems remains to be investigated.

Improving the Document Development Process: Integrating Relational Data and Statistical Process Control.

ERIC Educational Resources Information Center

Miller, John

1994-01-01

Presents an approach to document numbering, document titling, and process measurement which, when used with fundamental techniques of statistical process control, reveals meaningful process-element variation as well as nominal productivity models. (SR)

Safety and fitness electronic records (SAFER) system : logical architecture document : working draft

DOT National Transportation Integrated Search

1997-01-31

This Logical Architecture Document includes the products developed during the functional analysis of the Safety and Fitness Electronic Records (SAFER) System. This document, along with the companion Operational Concept and Physical Architecture Docum...

"Below the Line": The tobacco industry and youth smoking.

PubMed

Coombs, Jaimee; Bond, Laura; Van, Victoria; Daube, Mike

2011-01-01

This paper provides a comprehensive account of how the tobacco industry, over time, has promoted its products to young people. A comprehensive search of tobacco industry documents relating to youth smoking was conducted using documents available on the World Wide Web through the Master Settlement Agreement. The documents provide evidence that the industry invested great time and resources in developing strategies to attract young people through Youth Smoking Prevention strategies (including education strategies) and marketing to youth. The results include information from published literature and direct excerpts from the tobacco industry documents. The tobacco industry documents confirm that the tobacco industry has promoted and supported strategies that are ineffective in reducing smoking by youth, and opposed strategies that have proven to be effective. It is clear from the documents reviewed that the industry values the youth market and through a number of measures continues to promote its products to young people.

Plate Boundary Observatory Infrastructure and Data Products in Education and Outreach

NASA Astrophysics Data System (ADS)

Eriksson, S. C.; Barbour, K.; Lee, E.

2005-12-01

As one of three major components of NSF's EarthScope program, the Plate Boundary Observatory (PBO) encourages the integration of research and education. Informing various communities about the current work of PBO and the scientific discoveries related to the use of this instrumentation has contributed to the success of PBO during the first two years of the EarthScope project. UNAVCO(PBO), IRIS (USArray), and the EarthScope project office work together to integrate Education and Outreach (E&O) opportunities into a program that is greater than the sum of its parts and yet maintains the identity of each organization. Building and maintaining the PBO website, documenting and archiving activities of PBO, providing short courses for professional development of scientists using EarthScope data, and developing higher level data products with an appropriate educational framework are a few of the activities that provide both challenges and opportunities. The internet, particularly the World Wide Web, has become the primary tool for disseminating information to various audiences. The primary goals of the PBO website are to provide current information on the progress of GPS and Strainmeter facility construction; to provide access to different levels of data products; and to facilitate networking with and among scientists. Challenges for the PBO website include publishing current stories on installation projects while coordinating with field engineers on a regular basis; providing near to real time updates and maintaining quality assurance processes; and defining personnel requirements for a maintaining a dynamic website. Currently, archived photographs, web diaries, and numerous web highlights document PBO's success and provide a visual record of PBO's accomplishments and behind-the-scene activities over the last two years. The community charged PBO with increasing the number of scientists using its data. UNAVCO does this by providing short courses for professional development of young scientists and more established scientists broadening their research interests. In addition, collecting, manipulating, and aggregating real scientific data for classroom use is a current priority in science education. Educators want their students to use these data to draw conclusions following the logical processes characteristic of the scientific endeavor. Hence, PBO is a natural source of data for use in the classroom. Staff and community members are designing higher level data products for a variety of audiences in formal education (students and instructors in middle/high school, community colleges, undergraduate science majors and students in general science education, graduate students) and in informal education (museums, park information centers, science centers, and media. PBO is working on a chapter for the Earth Exploration Toolbox (http://serc.carleton.edu/eet/) for undergraduate general science education, and the Jules Verne Voyager will include a user-friendly interface and associated educational materials. Evaluation of the effectiveness of this entire program and of individual projects and products is a major undertaking. The multitude of tasks, integration of these tasks into a coherent program, and identification of resources for evaluation are both opportunities and challenges in helping build a program with measurable impact.

[Computer graphic display of retinal examination results. Software improving the quality of documenting fundus changes].

PubMed

Jürgens, Clemens; Grossjohann, Rico; Czepita, Damian; Tost, Frank

2009-01-01

Graphic documentation of retinal examination results in clinical ophthalmological practice is often depicted using pictures or in handwritten form. Popular software products used to describe changes in the fundus do not vary much from simple graphic programs that enable to insert, scale and edit basic graphic elements such as: a circle, rectangle, arrow or text. Displaying the results of retinal examinations in a unified way is difficult to achieve. Therefore, we devised and implemented modern software tools for this purpose. A computer program enabling to quickly and intuitively form graphs of the fundus, that can be digitally archived or printed was created. Especially for the needs of ophthalmological clinics, a set of standard digital symbols used to document the results of retinal examinations was developed and installed in a library of graphic symbols. These symbols are divided into the following categories: preoperative, postoperative, neovascularization, retinopathy of prematurity. The appropriate symbol can be selected with a click of the mouse and dragged-and-dropped on the canvas of the fundus. Current forms of documenting results of retinal examinations are unsatisfactory, due to the fact that they are time consuming and imprecise. Unequivocal interpretation is difficult or in some cases impossible. Using the developed computer program a sketch of the fundus can be created much more quickly than by hand drawing. Additionally the quality of the medica documentation using a system of well described and standardized symbols will be enhanced. (1) Graphic symbols used to document the results of retinal examinations are a part of everyday clinical practice. (2) The designed computer program will allow quick and intuitive graphical creation of fundus sketches that can be either digitally archived or printed.

Quantitative evaluation of Iranian radiology papers and its comparison with selected countries.

PubMed

Ghafoori, Mahyar; Emami, Hasan; Sedaghat, Abdolrasoul; Ghiasi, Mohammad; Shakiba, Madjid; Alavi, Manijeh

2014-01-01

Recent technological developments in medicine, including modern radiology have promoted the impact of scientific researches on social life. The scientific outputs such as article and patents are products that show the scientists' attempt to access these achievements. In the current study, we evaluate the current situation of Iranian scientists in the field of radiology and compare it with the selected countries in terms of scientific papers. For this purpose, we used scientometric tools to quantitatively assess the scientific papers in the field of radiology. Radiology papers were evaluated in the context of medical field audit using retrospective model. We used the related databases of biomedical sciences for extraction of articles related to radiology. In the next step, the situation of radiology scientific products of the country were determined with respect to the under study regional countries. Results of the current study showed a ratio of 0.19% for Iranian papers in PubMed database published in 2009. In addition, in 2009, Iranian papers constituted 0.29% of the Scopus scientific database. The proportion of Iranian papers in the understudy region was 7.6%. To diminish the gap between Iranian scientific radiology papers and other competitor countries in the region and achievement of document 2025 goals, multifold effort of the society of radiology is necessary.

Contingency Contractor Optimization Phase 3 Sustainment Requirements Document Contingency Contractor Optimization Tool - Prototype

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bandlow, Alisa; Durfee, Justin David; Frazier, Christopher Rawls

2016-05-01

This requirements document serves as an addendum to the Contingency Contractor Optimization Phase 2, Requirements Document [1] and Phase 3 Requirements Document [2]. The Phase 2 Requirements document focused on the high-level requirements for the tool. The Phase 3 Requirements document provided more detailed requirements to which the engineering prototype was built in Phase 3. This document will provide detailed requirements for features and enhancements being added to the production pilot in the Phase 3 Sustainment.

Using Model-Based Systems Engineering To Provide Artifacts for NASA Project Life-Cycle and Technical Reviews

NASA Technical Reports Server (NTRS)

Parrott, Edith L.; Weiland, Karen J.

2017-01-01

The ability of systems engineers to use model-based systems engineering (MBSE) to generate self-consistent, up-to-date systems engineering products for project life-cycle and technical reviews is an important aspect for the continued and accelerated acceptance of MBSE. Currently, many review products are generated using labor-intensive, error-prone approaches based on documents, spreadsheets, and chart sets; a promised benefit of MBSE is that users will experience reductions in inconsistencies and errors. This work examines features of SysML that can be used to generate systems engineering products. Model elements, relationships, tables, and diagrams are identified for a large number of the typical systems engineering artifacts. A SysML system model can contain and generate most systems engineering products to a significant extent and this paper provides a guide on how to use MBSE to generate products for project life-cycle and technical reviews. The use of MBSE can reduce the schedule impact usually experienced for review preparation, as in many cases the review products can be auto-generated directly from the system model. These approaches are useful to systems engineers, project managers, review board members, and other key project stakeholders.

Cosmetic preservative labelling on the Thai market.

PubMed

Bunyavaree, Monthathip; Kasemsarn, Pranee; Boonchai, Waranya

2016-04-01

Preservatives are added to cosmetics and other consumer products to prevent microbial growth and product degradation. Many cosmetic preservatives are skin sensitizers and frequent causes of contact dermatitis. The use of preservatives may vary by country and/or region, according to legislation, and may be reflected in differences in the prevalence rates of preservative allergy worldwide. To examine the type and frequency of preservative use in cosmetics sold in Thai markets in metropolitan Bangkok, Thailand. Preservatives contained in 1000 different cosmetics sold in Thai markets were documented and analysed, based on the labelling of ingredients. Most of the cosmetic and skincare products sold in Thai markets were international brands, with only a small proportion of cosmetic products being produced in Thailand. International brand cosmetics were more likely to contain non-formaldehyde-releasing preservatives than domestically produced brands. Isothiazolinone-based preservatives, which are responsible for the current increase in the prevalence of contact allergy, were found at a significant frequency in domestically produced, leave-on cosmetic products. Preservatives in cosmetics were significantly different according to source of production and type of cosmetics. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Product Structure, the Heart of Product Definition

NASA Technical Reports Server (NTRS)

DeHoog, C., Jr.

1999-01-01

This paper describes the LMMSS Product Definition System (PDS) philosophy and approach were the use of each item parts document or software can be traced to a specific end item (EI) serial/tail number of the product. It explains why a part-oriented approach to data organization and configuration management is required. The definition of part-oriented is that all appropriate product definition data products will be collected. Referenced and managed by their linkage/relationship to parts/items, The paper will touch upon how LMMSS store/controls product definition information under each project's top product designator in a two tiered approach. One tier for each product end item and another tier which contain/controls listings of drawings, documents. Specifications and standards that are required for hardware item definition.

Characterization of Downstream Ion Energy Distributions From a High Current Hollow Cathode in a Ring Cusp Discharge Chamber

NASA Technical Reports Server (NTRS)

Foster, John E.; Patterson, Michael J.

2003-01-01

The presence of energetic ions produced by a hollow cathodes operating at high emission currents (greater than 10 Angstroms) has been documented in the literature. As part of an ongoing effort to uncover the underlying physics of the formation of these ions, ion efflux from a high current hollow cathode operating in an ion thruster discharge chamber was investigated. Using a spherical sector electrostatic energy analyzer located downstream of the discharge cathode, the ion energy distribution over a 0 to 60 eV energy range was measured. The sensitivity of the ion energy distribution function to zenith angle was also assessed at 3 different positions: 0, 15, and 25 degrees. The measurements suggest that the majority of the ion current at the measuring point falls into the analyzer with an energy approximately equal to the discharge voltage. The ion distribution, however, was found to be quite broad. The high energy tail of the distribution function tended to grow with increasing discharge current. Sensitivity of the profiles to flow rate at fixed discharge current was also investigated. A simple model is presented that provides a potential mechanism for the production of ions with energies above the discharge voltage.

Advance Care Planning Documentation in Electronic Health Records: Current Challenges and Recommendations for Change.

PubMed

Lamas, Daniela; Panariello, Natalie; Henrich, Natalie; Hammes, Bernard; Hanson, Laura C; Meier, Diane E; Guinn, Nancy; Corrigan, Janet; Hubber, Sean; Luetke-Stahlman, Hannah; Block, Susan

2018-04-01

To develop a set of clinically relevant recommendations to improve the state of advance care planning (ACP) documentation in the electronic health record (EHR). Advance care planning (ACP) is a key process that supports goal-concordant care. For preferences to be honored, clinicians must be able to reliably record, find, and use ACP documentation. However, there are no standards to guide ACP documentation in the electronic health record (EHR). We interviewed 21 key informants to understand the strengths and weaknesses of EHR documentation systems for ACP and identify best practices. We analyzed these interviews using a qualitative content analysis approach and subsequently developed a preliminary set of recommendations. These recommendations were vetted and refined in a second round of input from a national panel of content experts. Informants identified six themes regarding current inadequacies in documentation and accessibility of ACP information and opportunities for improvement. We offer a set of concise, clinically relevant recommendations, informed by expert opinion, to improve the state of ACP documentation in the EHR.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hardin, Dave; Stephan, Eric G.; Wang, Weimin

Through its Building Technologies Office (BTO), the United States Department of Energy’s Office of Energy Efficiency and Renewable Energy (DOE-EERE) is sponsoring an effort to advance interoperability for the integration of intelligent buildings equipment and automation systems, understanding the importance of integration frameworks and product ecosystems to this cause. This is important to BTO’s mission to enhance energy efficiency and save energy for economic and environmental purposes. For connected buildings ecosystems of products and services from various manufacturers to flourish, the ICT aspects of the equipment need to integrate and operate simply and reliably. Within the concepts of interoperability liemore » the specification, development, and certification of equipment with standards-based interfaces that connect and work. Beyond this, a healthy community of stakeholders that contribute to and use interoperability work products must be developed. On May 1, 2014, the DOE convened a technical meeting to take stock of the current state of interoperability of connected equipment and systems in buildings. Several insights from that meeting helped facilitate a draft description of the landscape of interoperability for connected buildings, which focuses mainly on small and medium commercial buildings. This document revises the February 2015 landscape document to address reviewer comments, incorporate important insights from the Buildings Interoperability Vision technical meeting, and capture thoughts from that meeting about the topics to be addressed in a buildings interoperability vision. In particular, greater attention is paid to the state of information modeling in buildings and the great potential for near-term benefits in this area from progress and community alignment.« less

Investigation of a thiazolidinone derivative as an allosteric modulator of follicle stimulating hormone receptor: evidence for its ability to support follicular development and ovulation.

PubMed

Sriraman, Venkataraman; Denis, Deborah; de Matos, Daniel; Yu, Henry; Palmer, Stephen; Nataraja, Selva

2014-05-15

FSH signalling through its cognate receptor is critical for follicular development and ovulation. An earlier study had documented thiazolidinone derivatives to activate FSH receptor expressed in CHO cells and rat granulosa cells; however development of this compound for clinical use was halted for unobvious reasons. The objective of the current study is to extend the previous investigations in detail on the ability of thiazolidinone derivative (henceforth referred to as Compound 5) to activate FSH signalling and learn the barriers that preclude development of this derivative for clinical purposes. Our results demonstrate that the Compound 5 in a dose-dependent manner stimulated cAMP production, activated AKT and ERK signalling pathways and induced estradiol production in cultured rat granulosa cells. Compound 5 also caused dose-dependent increase in estradiol production from human granulosa cells. In increasingly more complex in vitro systems, Compound 5 was able to induce the expansion of mouse cumulus-oocyte-complex and support in vitro development of mouse preantral follicle to preovulatory stage and release of oocyte from the follicle. In vivo, the compound stimulated preovulatory follicular development and ovulation in immature rats. Pharmacokinetic and safety investigations reveal poor oral availability and genotoxicity. Together, our results document Compound 5 to act as a FSHR allosteric modulator but have poor pharmacological properties for development of an oral FSH receptor modulator. Copyright © 2014 Elsevier Inc. All rights reserved.

Using Inspections to Improve the Quality of Product Documentation and Code.

ERIC Educational Resources Information Center

Zuchero, John

1995-01-01

Describes how, by adapting software inspections to assess documentation and code, technical writers can collaborate with development personnel, editors, and customers to dramatically improve both the quality of documentation and the very process of inspecting that documentation. Notes that the five steps involved in the inspection process are:…

12 CFR 19.25 - Request for document discovery from parties.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Request for document discovery from parties. 19... PRACTICE AND PROCEDURE Uniform Rules of Practice and Procedure § 19.25 Request for document discovery from... for production and performing any related acts. In lieu of inspecting the documents, the requesting...

Development of Souvenir Production Transaction Processing System

NASA Astrophysics Data System (ADS)

Rumambi, H.; Kaparang, R.; Lintong, J.

2018-01-01

This research aims to design a souvenir production transaction processing system for the craftsmen in North Sulawesi. The craftsmen make very simple recordings about souvenir production transactions and use documents that are not in accordance with the generally accepted accounting practices. This research uses qualitative method. The data is collected through interviews, observations, documents and literatures studies. The research stages are conducted in preliminary studies, data collection, data analyzed and system design. The design of system is built from chart of account, accounting cycle and documents as input and get processed in accounting recording. The outputs are financial statements. The system design provides benefits for the craftsmen in assessing the financial performance and getting financing from bank.

Rhode Island Water Supply System Management Plan Database (WSSMP-Version 1.0)

USGS Publications Warehouse

Granato, Gregory E.

2004-01-01

In Rhode Island, the availability of water of sufficient quality and quantity to meet current and future environmental and economic needs is vital to life and the State's economy. Water suppliers, the Rhode Island Water Resources Board (RIWRB), and other State agencies responsible for water resources in Rhode Island need information about available resources, the water-supply infrastructure, and water use patterns. These decision makers need historical, current, and future water-resource information. In 1997, the State of Rhode Island formalized a system of Water Supply System Management Plans (WSSMPs) to characterize and document relevant water-supply information. All major water suppliers (those that obtain, transport, purchase, or sell more than 50 million gallons of water per year) are required to prepare, maintain, and carry out WSSMPs. An electronic database for this WSSMP information has been deemed necessary by the RIWRB for water suppliers and State agencies to consistently document, maintain, and interpret the information in these plans. Availability of WSSMP data in standard formats will allow water suppliers and State agencies to improve the understanding of water-supply systems and to plan for future needs or water-supply emergencies. In 2002, however, the Rhode Island General Assembly passed a law that classifies some of the WSSMP information as confidential to protect the water-supply infrastructure from potential terrorist threats. Therefore the WSSMP database was designed for an implementation method that will balance security concerns with the information needs of the RIWRB, suppliers, other State agencies, and the public. A WSSMP database was developed by the U.S. Geological Survey in cooperation with the RIWRB. The database was designed to catalog WSSMP information in a format that would accommodate synthesis of current and future information about Rhode Island's water-supply infrastructure. This report documents the design and implementation of the WSSMP database. All WSSMP information in the database is, ultimately, linked to the individual water suppliers and to a WSSMP 'cycle' (which is currently a 5-year planning cycle for compiling WSSMP information). The database file contains 172 tables - 47 data tables, 61 association tables, 61 domain tables, and 3 example import-link tables. This database is currently implemented in the Microsoft Access database software because it is widely used within and outside of government and is familiar to many existing and potential customers. Design documentation facilitates current use and potential modification for future use of the database. Information within the structure of the WSSMP database file (WSSMPv01.mdb), a data dictionary file (WSSMPDD1.pdf), a detailed database-design diagram (WSSMPPL1.pdf), and this database-design report (OFR2004-1231.pdf) documents the design of the database. This report includes a discussion of each WSSMP data structure with an accompanying database-design diagram. Appendix 1 of this report is an index of the diagrams in the report and on the plate; this index is organized by table name in alphabetical order. Each of these products is included in digital format on the enclosed CD-ROM to facilitate use or modification of the database.

Trends in liability affecting technical writers

NASA Technical Reports Server (NTRS)

Driskill, L. P.

1981-01-01

Liability of technical writers for defective products is explored. Documents generated during a product's life cycle (including design memos, design tests, clinical trials, trial use reports, letters, and proposals) become relevant because they are likely to become the only available means of showing that the product was not defectively designed. These documents become the evidence that the product underwent balanced and well considered planning, development, testing, quality control, and field testing. The predicted increased involvement of technical writers in the prevention and defense of product liability claims is cited in view of a greater number of cases turning on "failure to warn".

An ethnobotanical perspective on traditional fermented plant foods and beverages in Eastern Europe.

PubMed

Sõukand, Renata; Pieroni, Andrea; Biró, Marianna; Dénes, Andrea; Dogan, Yunus; Hajdari, Avni; Kalle, Raivo; Reade, Benedict; Mustafa, Behxhet; Nedelcheva, Anely; Quave, Cassandra L; Łuczaj, Łukasz

2015-07-21

Fermented food and beverages represent an important part of the worldwide foodscape, medicinal food domain and domestic strategies of health care, yet relevant traditional knowledge in Europe is poorly documented. Review of primary ethnographic literature, archival sources and a few ad-hoc ethnobotanical field studies in seven selected Eastern European countries (Albania, Belarus, Bulgaria, Estonia, Hungary, Kosovo, and Poland) were conducted. Current or recently abandoned uses of 116 botanical taxa, belonging to 37 families in fermented food or medicinal food products were recorded. These findings demonstrate a rich bio-cultural diversity of use, and also a clear prevalence of the use of fruits of the tannin- and phenolic-rich Rosaceae species in alcoholic, lactic- and acetic acid fermented preparations. In the considered countries, fermentation still plays (or has played until recent years) a crucial role in folk cuisines and this heritage requires urgent and in-depth evaluation. Future studies should be aimed at further documenting and also bio-evaluating the ingredients and processes involved in the preparation of homemade fermented products, as this can be used to support local, community-based development efforts to foster food security, food sovereignty, and small-scale local food-based economies. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

[Consensus document: nutritional and metabolic importance of cow's milk].

PubMed

Fernández Fernández, Elena; Martínez Hernández, José Alfredo; Martínez Suárez, Venancio; Moreno Villares, José Manuel; Collado Yurrita, Luis Rodolfo; Hernández Cabria, Marta; Morán Rey, Francisco Javier

2014-10-25

Cow's milk is a staple food for human consumption at all stages of life. Industrial processing has allowed widespread access to its consumption by the population, which has helped to significantly improve their health. From its composition point of view, milk is a complete and balanced food that provides high nutrient content in relation to its calorie content, so its consumption should be considered necessary from childhood to elderly. The benefits of cow's milk are not limited to its nutritional value, but extend beyond and are a factor of prevention in certain non communicable pathologies as cardiovascular disease, some cancers, high blood pressure or bone or dental pathology. It can also help in the fight against childhood overweight and obesity. In recent years we have seen a worrying decline in milk consumption among the Spanish population, at least in part influenced by misconceptions about its consumption and of other dairy products. This consensus document aims to review the current state of the topic regarding the effects of milk consumption on health, while making a call to the institutions and scientific societies to develop programs and information campaigns about the benefits of milk and dairy products consumption. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

D Cultural Heritage Documentation: a Comparison Between Different Photogrammetric Software and Their Products

NASA Astrophysics Data System (ADS)

Gagliolo, S.; Ausonio, E.; Federici, B.; Ferrando, I.; Passoni, D.; Sguerso, D.

2018-05-01

The conservation of Cultural Heritage depends on the availability of means and resources and, consequently, on the possibility to make effective operations of data acquisition. In facts, on the one hand the creation of data repositories allows the description of the present state-of-art, in order to preserve the testimonial value and to permit the fruition. On the other hand, data acquisition grants a metrical knowledge, which is particularly useful for a direct restoration of the surveyed objects, through the analysis of their 3D digital models. In the last decades, the continuous increase and improvement of 3D survey techniques and of tools for the geometric and digital data management have represented a great support to the development of documentary activities. In particular, Photogrammetry is a survey technique highly appropriate in the creation of data repositories in the field of Cultural Heritage, thanks to its advantages of cheapness, flexibility, speed, and the opportunity to ensure the operators' safety in hazardous areas too. In order to obtain a complete documentation, the high precision of the on-site operations must be coupled with an effective post-processing phase. Hence, a comparison among some of the photogrammetric software currently available was performed by the authors, with a particular attention to the workflow completeness and the final products quality.

Connected Vehicle Impacts on Transportation Planning—Outreach to Planning Community.

DOT National Transportation Integrated Search

2016-06-01

This document presents outreach memos on 11 case studies analyzing the impacts of connected and automated vehicles (C/AV) on transportation planning products. These 11 case studies are documented indepth in the associated project document entitled Co...

75 FR 80517 - HUD Multifamily Rental Project Closing Documents-Revisions and Updates Notice of Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-22

... familiar with the updated closing documents, the existing closing documents, which these updated closing... assures the industry and the public that sufficient staff will be available and thoroughly familiar with... documents that are updated for current commercial legal standards, balanced with the public policy role that...

Documenting Outcomes for Learners and Their Communities: A Report on a NCSALL Action Research Project. NCSALL Reports.

ERIC Educational Resources Information Center

Bingman, Mary Beth

Action research focused on developing approaches local programs can use to document outcomes of student participation in adult basic education (ABE) programs. Teams of teachers and administrators from three ABE programs examined current documentation practices, were introduced to approaches to documentaion, and developed documentation processes…

The standardization of terminology of lower urinary tract function in children and adolescents: Update report from the standardization committee of the International Children's Continence Society.

PubMed

Austin, Paul F; Bauer, Stuart B; Bower, Wendy; Chase, Janet; Franco, Israel; Hoebeke, Piet; Rittig, Søren; Walle, Johan Vande; von Gontard, Alexander; Wright, Anne; Yang, Stephen S; Nevéus, Tryggve

2016-04-01

The impact of the original International Children's Continence Society (ICCS) terminology document on lower urinary tract (LUT) function resulted in the global establishment of uniformity and clarity in the characterization of LUT function and dysfunction in children across multiple healthcare disciplines. The present document serves as a stand-alone terminology update reflecting refinement and current advancement of knowledge on pediatric LUT function. A variety of worldwide experts from multiple disciplines within the ICCS leadership who care for children with LUT dysfunction were assembled as part of the standardization committee. A critical review of the previous ICCS terminology document and the current literature was performed. Additionally, contributions and feedback from the multidisciplinary ICCS membership were solicited. Following a review of the literature over the last 7 years, the ICCS experts assembled a new terminology document reflecting current understanding of bladder function and LUT dysfunction in children using the resources from the literature review, expert opinion and ICCS member feedback. The present ICCS terminology document provides a current and consensus update to the evolving terminology and understanding of LUT function in children. Neurourol. Urodynam. 35:471-481, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

Data Provenance in Photogrammetry Through Documentation Protocols

NASA Astrophysics Data System (ADS)

Carboni, N.; Bruseker, G.; Guillem, A.; Bellido Castañeda, D.; Coughenour, C.; Domajnko, M.; de Kramer, M.; Ramos Calles, M. M.; Stathopoulou, E. K.; Suma, R.

2016-06-01

Documenting the relevant aspects in digitisation processes such as photogrammetry in order to provide a robust provenance for their products continues to present a challenge. The creation of a product that can be re-used scientifically requires a framework for consistent, standardised documentation of the entire digitisation pipeline. This article provides an analysis of the problems inherent to such goals and presents a series of protocols to document the various steps of a photogrammetric workflow. We propose this pipeline, with descriptors to track all phases of digital product creation in order to assure data provenance and enable the validation of the operations from an analytic and production perspective. The approach aims to support adopters of the workflow to define procedures with a long term perspective. The conceptual schema we present is founded on an analysis of information and actor exchanges in the digitisation process. The metadata were defined through the synthesis of previous proposals in this area and were tested on a case study. We performed the digitisation of a set of cultural heritage artefacts from an Iron Age burial in Ilmendorf, Germany. The objects were captured and processed using different techniques, including a comparison of different imaging tools and algorithms. This augmented the complexity of the process allowing us to test the flexibility of the schema for documenting complex scenarios. Although we have only presented a photogrammetry digitisation scenario, we claim that our schema is easily applicable to a multitude of 3D documentation processes.

Monitoring and remediation of on-farm and off-farm ground current measured as step potential on a Wisconsin dairy farm: A case study.

PubMed

Stetzer, Dave; Leavitt, Adam M; Goeke, Charles L; Havas, Magda

2016-01-01

Ground current commonly referred to as "stray voltage" has been an issue on dairy farms since electricity was first brought to rural America. Equipment that generates high-frequency voltage transients on electrical wires combined with a multigrounded (electrical distribution) system and inadequate neutral returns all contribute to ground current. Despite decades of problems, we are no closer to resolving this issue, in part, due to three misconceptions that are addressed in this study. Misconception 1. The current standard of 1 V at cow contact is adequate to protect dairy cows; Misconception 2. Frequencies higher than 60 Hz do not need to be considered; and Misconception 3. All sources of ground current originate on the farm that has a ground current problem. This case study of a Wisconsin dairy farm documents, 1. how to establish permanent monitoring of ground current (step potential) on a dairy farm; 2. how to determine and remediate both on-farm and off-farm sources contributing to step potential; 3. which step-potential metrics relate to cow comfort and milk production; and 4. how these metrics relate to established standards. On-farm sources include lighting, variable speed frequency drives on motors, radio frequency identification system and off-farm sources are due to a poor primary neutral return on the utility side of the distribution system. A step-potential threshold of 1 V root mean square (RMS) at 60 Hz is inadequate to protect dairy cows as decreases of a few mV peak-peak at higher frequencies increases milk production, reduces milking time and improves cow comfort.

Command Center Library Model Document. Comprehensive Approach to Reusable Defense Software (CARDS)

DTIC Science & Technology

1992-05-31

system, and functionality for specifying the layout of the document. 3.7.16.1 FrameMaker FrameMaker is a Commercial Off The Shelf (COTS) component...facilitating WYSIWYG creation of formatted reports with embedded graphics. FrameMaker is an advanced publishing tool that integrates word processing...available for the component FrameMaker : * Product evaluation reports in ASCII and postscript formats • Product assessment on line in model 0 Product

Carbon Calculator for Land Use Change from Biofuels Production (CCLUB) Users’ Manual and Technical Documentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dunn, Jennifer B.; Qin, Zhangcai; Mueller, Steffen

The Carbon Calculator for Land Use Change from Biofuels Production (CCLUB) calculates carbon emissions from land use change (LUC) for four different ethanol production pathways including corn grain ethanol and cellulosic ethanol from corn stover, Miscanthus, and switchgrass, and a soy biodiesel pathway. This document discusses the version of CCLUB released September 30, 2017 which includes five ethanol LUC scenarios and four soy biodiesel LUC scenarios.

Movie moguls: British American Tobacco's covert strategy to promote cigarettes in Eastern Europe.

PubMed

LeGresley, Eric M; Muggli, Monique E; Hurt, Richard D

2006-10-01

Though the cigarette companies have long publicly denied paying for product placement in films, the documentary evidence from the 1950s-1980s overwhelmingly suggests otherwise. Approximately 800,000 pages of previously secret internal corporate British American Tobacco Company documents were reviewed at the Minnesota Tobacco Document Depository from March 2003 through May 2005. Documents were also searched online at the various tobacco document collections between February 2004 and November 2004. A small collection of internal corporate documents from British American Tobacco show that in the late 1990s the company evaluated investing in a movie destined for Eastern Europe. By being an investor, BAT could influence the alteration of the movie script to promote BAT's brands, thus providing marketing opportunities without a clear violation of movie product placement restrictions. Future protocols to the WHO Framework Convention on Tobacco Control should seek to curtail more than just payment for tobacco product placement. More restrictive provisions will be needed to hinder creative strategies by the tobacco industry to continue tobacco promotion and trademark diversification through movies.

9 CFR 93.206 - Declaration and other documents for poultry.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Declaration and other documents for poultry. 93.206 Section 93.206 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE..., the name and address of the broker, the origin of the poultry, the number, breed, species, and purpose...

9 CFR 93.506 - Declaration and other documents for swine.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Declaration and other documents for swine. 93.506 Section 93.506 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... and address of the broker, the origin of the swine, the number, breed, species, and purpose of the...

9 CFR 93.407 - Declaration and other documents for ruminants.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Declaration and other documents for ruminants. 93.407 Section 93.407 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... importer, the name and address of the broker, the origin of the ruminants, the number, breed, species, and...

9 CFR 93.305 - Declaration and other documents for horses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Declaration and other documents for horses. 93.305 Section 93.305 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... name and address of the broker, the origin of the horses, the number, breed, species, and purpose of...

19 CFR 210.30 - Requests for production of documents and things and entry upon land.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Requests for production of documents and things and entry upon land. 210.30 Section 210.30 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Discovery and Compulsory Process...

International directory of documentation services concerning forestry and forest products

Treesearch

Peter A. Evans; Gary L. Skupa

1981-01-01

This directory lists 120 documentation services concerned with forestry, forest products, or related fields in 28 countries. The entry for each service includes title of service, cost, publisher, subject coverage, formatting data, input sources, indexing and data-handling methods, and availability of special services other than the primary ones of indexing and...

27 CFR 18.17 - Retention of documents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Retention of documents. 18.17 Section 18.17 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... Budget under control number 1512-0046) [T.D. ATF-104, 47 FR 23921, June 2, 1982, as amended by T.D. ATF...

The New Philanthropist: Eric Schnell--Ohio State University

ERIC Educational Resources Information Center

Library Journal, 2005

2005-01-01

As head of information technology at the Prior Health Sciences Library, Eric Schnell likes to improve products that don't fully meet his library's purposes. His first major software product, the award-winning Prospero Electronic Delivery Project, is a web-based document delivery system designed to complement Ariel[R] by converting documents to a…

45 CFR 2.3 - Policy on Presentation of testimony and production of documents.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ADMINISTRATION TESTIMONY BY EMPLOYEES AND PRODUCTION OF DOCUMENTS IN PROCEEDINGS WHERE THE UNITED STATES IS NOT A... person's official relationship with the Department unless authorized by the Agency head pursuant to this part based on a determination by the Agency head, after consultation with the Office of the General...

Menthol's potential effects on nicotine dependence: a tobacco industry perspective.

PubMed

Yerger, Valerie B

2011-05-01

To examine what the tobacco industry knows about the potential effects menthol may have on nicotine dependence. A snowball strategy was used to systematically search the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu/) between 22 February and 29 April, 2010. Of the approximately 11 million documents available in the Legacy Tobacco Documents Library, the iterative searches returned tens of thousands of results. We qualitatively analysed a final collection of 309 documents relevant the effects of menthol on nicotine dependence. The tobacco industry knows that menthol overrides the harsh taste of tobacco and alleviates nicotine's irritating effects, synergistically interacts with nicotine, stimulates the trigeminal nerve to elicit a 'liking' response for a tobacco product, and makes low tar, low nicotine tobacco products more acceptable to smokers than non-mentholated low delivery products. Menthol is not only used in cigarettes as a flavour additive; tobacco companies know that menthol also has sensory effects and interacts with nicotine to produce tobacco products that are easier to smoke, thereby making it easier to expose smokers, especially those who are new and uninitiated, to the addictive power of nicotine.

Development of a Software Tool to Automate ADCO Flight Controller Console Planning Tasks

NASA Technical Reports Server (NTRS)

Anderson, Mark G.

2011-01-01

This independent study project covers the development of the International Space Station (ISS) Attitude Determination and Control Officer (ADCO) Planning Exchange APEX Tool. The primary goal of the tool is to streamline existing manual and time-intensive planning tools into a more automated, user-friendly application that interfaces with existing products and allows the ADCO to produce accurate products and timelines more effectively. This paper will survey the current ISS attitude planning process and its associated requirements, goals, documentation and software tools and how a software tool could simplify and automate many of the planning actions which occur at the ADCO console. The project will be covered from inception through the initial prototype delivery in November 2011 and will include development of design requirements and software as well as design verification and testing.

Consolidated Development Objectives Document (CDOD) For MB-60

NASA Technical Reports Server (NTRS)

Greene, William D.

2013-01-01

This document defines the objectives related to liquid rocket engine system development to be undertaken by JAXA in support of the Space Launch System (SLS) Program managed out of the NASA Marshall Space Flight Center (MSFC). These objectives include furnishing the necessary management, labor, facilities, tools, equipment, and materials required to execute the specified activities. 1.1 Project Scope: The scope of this effort is to develop a rocket engine and associated products per the objectives and technical requirements established in this document. This engine, minus the engine controller, designated here as MB ]60, is to be developed through to a prequalification point of maturity. It is assumed that should JCNE ]1 development proceed beyond this maturity point towards actual flight qualification, the engine controller will be supplied and integrated by NASA. 1.2 Document Structure: The structure of this Consolidated Development Objectives Document (CDOD) includes a traditional description of objectives in a SOO, plus the associated Data Products Document (DPD) in an attached appendix, and then Engine Requirements Document (ERD) as another attached appendix. It is the intent that this document, in conjunction with the cited applicable documents, should constitute a complete programmatic and technical description of the development effort to be pursued.

The NASA Astrophysics Data System: Capabilities and Roadmap for the 2020s

NASA Astrophysics Data System (ADS)

Accomazzi, Alberto; ADS Team

2018-06-01

The NASA Astrophysics Data System (ADS) is used daily by researchers and curators as a discovery platform for the Astronomy literature. Over the past several years, the ADS has been adding to the breadth and depth of its contents. Scholarly astronomy articles are now indexed as full-text documents, allowing for complete and accurate literature searches. High-level data products, data links, and software used in refereed astronomy papers are now also being ingested and indexed in our database. All the search functionality exposed in the new ADS interface is also available via its API, which we are continuing to develop and enhance. In this talk I will describe the current system, our current roadmap, and solicit input from the community regarding what additional data, services, and discovery capabilities the ADS should support.

Dependability of technical items: Problems of standardization

NASA Astrophysics Data System (ADS)

Fedotova, G. A.; Voropai, N. I.; Kovalev, G. F.

2016-12-01

This paper is concerned with problems blown up in the development of a new version of the Interstate Standard GOST 27.002 "Industrial product dependability. Terms and definitions". This Standard covers a wide range of technical items and is used in numerous regulations, specifications, standard and technical documentation. A currently available State Standard GOST 27.002-89 was introduced in 1990. Its development involved a participation of scientists and experts from different technical areas, its draft was debated in different audiences and constantly refined, so it was a high quality document. However, after 25 years of its application it's become necessary to develop a new version of the Standard that would reflect the current understanding of industrial dependability, accounting for the changes taking place in Russia in the production, management and development of various technical systems and facilities. The development of a new version of the Standard makes it possible to generalize on a terminological level the knowledge and experience in the area of reliability of technical items, accumulated over a quarter of the century in different industries and reliability research schools, to account for domestic and foreign experience of standardization. Working on the new version of the Standard, we have faced a number of issues and problems on harmonization with the International Standard IEC 60500-192, caused first of all by different approaches to the use of terms and differences in the mentalities of experts from different countries. The paper focuses on the problems related to the chapter "Maintenance, restoration and repair", which caused difficulties for the developers to harmonize term definitions both with experts and the International Standard, which is mainly related to differences between the Russian concept and practice of maintenance and repair and foreign ones.

The impact of cigarette pack shape, size and opening: evidence from tobacco company documents.

PubMed

Kotnowski, Kathy; Hammond, David

2013-09-01

To use tobacco industry documents on cigarette pack shape, size and openings to identify industry findings on associations with brand imagery, product attributes, consumer perceptions and behaviour. Internal tobacco industry research and marketing documents obtained through court disclosure contained in the Legacy Tobacco Documents Library were searched using keywords related to pack shapes, sizes and opening methods. The search identified 66 documents related to consumer research and marketing plans on pack shape, size and openings, drawn from 1973 to 2002. Industry research consistently found that packs that deviated from the traditional flip-top box projected impressions of 'modern', 'elegant' and 'unique' brand imagery. Alternative pack shape and openings were identified as an effective means to communicate product attributes, particularly with regard to premium quality and smooth taste. Consumer studies consistently found that pack shape, size and opening style influenced perceptions of reduced product harm, and were often used to communicate a 'lighter' product. Slim, rounded, oval and booklet packs were found to be particularly appealing among young adults, and several studies demonstrated increased purchase interest for tobacco products presented in novel packaging shape or opening. Evidence from consumer tracking reports and company presentations indicate that pack innovations in shape or opening method increased market share of brands. Consumer research by the tobacco industry between 1973 and 2002 found that variations in packaging shape, size and opening method could influence brand appeal and risk perceptions and increase cigarette sales. © 2013 Society for the Study of Addiction.

Effect of Body-Worn Cameras on EMS Documentation Accuracy: A Pilot Study.

PubMed

Ho, Jeffrey D; Dawes, Donald M; McKay, Evan M; Taliercio, Jeremy J; White, Scott D; Woodbury, Blair J; Sandefur, Mark A; Miner, James R

2017-01-01

Current Emergency Medical Services (EMS) documentation practices usually occur from memory after an event is over. While this practice is fairly standard, it is unclear if it can introduce significant error. Modern technology has seen the increased use of recorded video by society to more objectively document notable events. Stationary mounted cameras, cell-phone cameras, and law enforcement officer Body-Worn Cameras (BWCs) are increasingly used by society for this purpose. Video used in this way can often clarify or contradict recall from memory. BWCs are currently not widely used by EMS. The hypothesis is that current EMS documentation practices are inaccurate and that BWCs will have a positive effect on documentation accuracy. This prospective, observational study used a convenience sample of paramedics in a simulation lab. The Paramedics wore a BWC and responded to a simulated call of "One Down" (unresponsive from heroin abuse) involving Role Players (RPs). The paramedics received standardized cues from the RPs during the simulation to keep it on track.  The simulation contained many factors of concern (e.g., weapons and drugs in plain view, unattended minors, etc.) and intentional stressors (e.g., distraught family member, uncooperative patient, etc.). Upon completion of the scenario, paramedic documentation occurred from memory on an electronic template.  After initial documentation, paramedics viewed their BWC recording and were allowed to make tabulated changes. Changes were categorized by a priori criteria as minor, moderate, or major.  Ten paramedics participated with an average age of 33.3 years (range 22-43), 8 males and 2 females. The average length of paramedic career experience was 7.7 years (range 2 months to 20 years). There were 71 total documentation changes (7 minor, 51 moderate, 13 major) made after video review. Linear regression (ANCOVA) indicated changes made indirectly correlated with years of experience (coefficient 8.27, 4.22-12.3, 95% CI, p = 0.002), but all made some changes. Current EMS documentation practices demonstrate significant inaccuracy regardless of years of experience. Use of BWC technology appears to significantly improve EMS documentation accuracy in this pilot study.

Ontology-based reusable clinical document template production system.

PubMed

Nam, Sejin; Lee, Sungin; Kim, James G Boram; Kim, Hong-Gee

2012-01-01

Clinical documents embody professional clinical knowledge. This paper shows an effective clinical document template (CDT) production system that uses a clinical description entity (CDE) model, a CDE ontology, and a knowledge management system called STEP that manages ontology-based clinical description entities. The ontology represents CDEs and their inter-relations, and the STEP system stores and manages CDE ontology-based information regarding CDTs. The system also provides Web Services interfaces for search and reasoning over clinical entities. The system was populated with entities and relations extracted from 35 CDTs that were used in admission, discharge, and progress reports, as well as those used in nursing and operation functions. A clinical document template editor is shown that uses STEP.

Human factors engineering in oil and gas--a review of industry guidance.

PubMed

Robb, Martin; Miller, Gerald

2012-01-01

Oil and gas exploration and production activities are carried out in hazardous environments in many parts of the world. Recent events in the Gulf of Mexico highlight those risks and underline the importance of considering human factors during facility design. Ergonomic factors such as machinery design, facility and accommodation layout and the organization of work activities have been systematically considered over the past twenty years on a limited number of offshore facility design projects to a) minimize the occupational risks to personnel, b) support operations and maintenance tasks and c) improve personnel wellbeing. During this period, several regulators and industry bodies such as the American Bureau of Shipping (ABS), the American Society of Testing and Materials (ASTM), the UK's Health and Safety Executive (HSE), Oil and Gas Producers (OGP), and Norway's Petroleum Safety Authority (PSA) have developed specific HFE design standards and guidance documents for the application of Human Factors Engineering (HFE) to the design and operation of Oil and Gas projects. However, despite the existence of these guidance and recommended design practise documents, and documented proof of their value in enhancing crew safety and efficiency, HFE is still not well understood across the industry and application across projects is inconsistent. This paper summarizes the key Oil and Gas industry bodies' HFE guidance documents, identifies recurring themes and current trends in the use of these standards, provides examples of where and how these HFE standards have been used on past major offshore facility design projects, and suggests criteria for selecting the appropriate HFE strategy and tasks for future major oil and gas projects. It also provides a short history of the application of HFE to the offshore industry, beginning with the use of ASTM F 1166 to a major operator's Deepwater Gulf of Mexico facility in 1990 and the application of HFE to diverse world regions. This latter point highlights the need to consider user populations when selecting HFE design criteria, an aspect strongly emphasized in current industry guidance.

A COMPREHENSIVE TECHNICAL REVIEW OF THE DEMONSTRATION BULK VITRIFICATION SYSTEM

DOE Office of Scientific and Technical Information (OSTI.GOV)

SCHAUS, P.S.

2006-09-29

In May 2006, CH2M Hill Hanford Group, Inc. chartered an Expert Review Panel (ERP) to review the current status of the Demonstration Bulk Vitrification System (DBVS). It is the consensus of the ERP that bulk vitrification is a technology that requires further development and evaluation to determine its potential for meeting the Hanford waste stabilization mission. No fatal flaws (issues that would jeopardize the overall DBVS mission that cannot be mitigated) were found, given the current state of the project. However, a number of technical issues were found that could significantly affect the project's ability to meet its overall missionmore » as stated in the project ''Justification of Mission Need'' document, if not satisfactorily resolved. The ERP recognizes that the project has changed from an accelerated schedule demonstration project to a formally chartered project that must be in full compliance with DOE 413.3 requirements. The perspective of the ERP presented herein, is measured against the formally chartered project as stated in the approved Justification of Mission Need document. A justification of Mission Need document was approved in July 2006 which defined the objectives for the DBVS Project. In this document, DOE concluded that bulk vitrification is a viable technology that requires additional development to determine its potential applicability to treatment of a portion of the Hanford low activity waste. The DBVS mission need statement now includes the following primary objectives: (1) process approximately 190,000 gallons of Tank S-109 waste into fifty 100 metric ton boxes of vitrified product; (2) store and dispose of these boxes at Hanford's Integrated Disposal Facility (IDF); (3) evaluate the waste form characteristics; (4) gather pilot plant operability data, and (5) develop the overall life cycle system performance of bulk vitrification and produce a comparison of the bulk vitrification process to building a second LAW Immobilization facility or other supplemental treatment alternatives as provided in M-62-08.« less

Applications of pharmacogenomics in regulatory science: a product life cycle review.

PubMed

Tan-Koi, W C; Leow, P C; Teo, Y Y

2018-05-22

With rapid developments of pharmacogenomics (PGx) and regulatory science, it is important to understand the current PGx integration in product life cycle, impact on clinical practice thus far and opportunities ahead. We conducted a cross-sectional review on PGx-related regulatory documents and implementation guidelines in the United States and Europe. Our review found that although PGx-related guidance in both markets span across the entire product life cycle, the scope of implementation guidelines varies across two continents. Approximately one-third of Food and Drug Administration (FDA)-approved drugs with PGx information in drug labels and half of the European labels posted on PharmGKB website contain recommendations on genetic testing. The drugs affected 19 and 15 World Health Organization Anatomical Therapeutic Chemical drug classes (fourth level) in the United States and Europe, respectively, with protein kinase inhibitors (13 drugs in the United States and 16 drugs in Europe) being most prevalent. Topics of emerging interest were novel technologies, adaptive design in clinical trial and sample collection.

Emission Inventory for PFOS in China: Review of Past Methodologies and Suggestions

PubMed Central

Lim, Theodore Chao; Wang, Bin; Huang, Jun; Deng, Shubo; Yu, Gang

2011-01-01

Perfluorooctane sulfonate (PFOS) is a persistent, bioaccumulative, and toxic chemical that has the potential for long-range transport in the environment. Its use in a wide variety of consumer products and industrial processes makes a detailed characterization of its emissions sources very challenging. These varied emissions sources all contribute to PFOS' existence within nearly all environmental media. Currently, China is the only country documented to still be producing PFOS, though there is no China PFOS emission inventory available. This study reviews the inventory methodologies for PFOS in other countries to suggest a China-specific methodology framework for a PFOS emission inventory. The suggested framework combines unknowns for PFOS-containing product penetration into the Chinese market with product lifecycle assumptions, centralizing these diverse sources into municipal sewage treatment plants. Releases from industrial sources can be quantified separately using another set of emission factors. Industrial sources likely to be relevant to the Chinese environment are identified. PMID:22125449

Cranberry juice for prophylaxis of urinary tract infections--conclusions from clinical experience and research.

PubMed

Nowack, Rainer; Schmitt, Wilhelm

2008-09-01

Cranberry juice (Vaccinium macrocarpon) is a widely used and recommended North-American folk remedy for prophylaxis of urinary tract infections (UTI). Clinical trials have documented its efficacy in women with recurrent UTI, but so far not in other groups of patients. The composition of effective cranberry products and its dosage in UTI prophylaxis have not been defined. Intriguing experimental research has identified an anti-adhesive mechanism of cranberry juice that prevents docking of bacteria on host tissues. This efficacy mechanism can be traced in patients' urine following oral intake of cranberry products and appears to be due to proanthocyanidins with an A-type linkage of flavanols. The application of this anti-adhesion mechanism of cranberry-proanthocyandins is currently also investigated in other common diseases of bacterial pathogenesis, for example Helicobacter pylori-associated gastritis and dental caries/periodontal disease. The use of cranberry products appears to be safe and provide additional benefits by anti-oxidant and cholesterol-lowering activity.

Documenting the decision structure in software development

NASA Technical Reports Server (NTRS)

Wild, J. Christian; Maly, Kurt; Shen, Stewart N.

1990-01-01

Current software development paradigms focus on the products of the development process. Much of the decision making process which produces these products is outside the scope of these paradigms. The Decision-Based Software Development (DBSD) paradigm views the design process as a series of interrelated decisions which involve the identification and articulation of problems, alternates, solutions and justifications. Decisions made by programmers and analysts are recorded in a project data base. Unresolved problems are also recorded and resources for their resolution are allocated by management according to the overall development strategy. This decision structure is linked to the products affected by the relevant decision and provides a process oriented view of the resulted system. Software maintenance uses this decision view of the system to understand the rationale behind the decisions affecting the part of the system to be modified. D-HyperCase, a prototype Decision-Based Hypermedia System is described and results of applying the DBSD approach during its development are presented.

Development of Hybrid Product Breakdown Structure for NASA Ground Systems

NASA Technical Reports Server (NTRS)

Monaghan, Mark W.; Henry, Robert J.

2013-01-01

The Product Breakdown Structure is traditionally a method of identification of the products of a project in a tree structure. It is a tool used to assess, plan, document, and display the equipment requirements for a project. It is part of a product based planning technique, and attempts to break down all components of a project in as much detail as possible, so that nothing is overlooked. The PBS for ground systems at the Kennedy Space Center is being developed to encompass the traditional requirements including the alignment of facility, systems, and components to the organizational hierarchy. The Ground Operations Product Breakdown Structure is a hybrid in nature in that some aspects of a work breakdown structure will be incorporated and merged with the Architecture Concept of Operations, Master Subsystem List, customer interface, and assigned management responsibility. The Ground Operations Product Breakdown Structure needs to be able to identify the flexibility of support differing customers (internal and external) usage of ground support equipment within the Kennedy Space Center launch and processing complex. The development of the Product Breakdown Structure is an iterative activity Initially documenting the organization hierarchy structure and relationships. The Product Breakdown Structure identifies the linkage between the customer program requirements, allocation of system resources, development of design goals, and identification logistics products. As the Product Breakdown Structure progresses the incorporation of the results of requirement planning for the customer occurs identifying facility needs and systems. The mature Product Breakdown Structure is baselined with a hierarchical drawing, the Product Breakdown Structure database, and an associated document identifying the verification of the data through the life cycle of the program/product line. This paper will document, demonstrate, and identify key aspects of the life cycle of a Hybrid Product Breakdown Structure. The purpose is to show how a project management and system engineering approach can be utilized for providing flexible customer service in an evolving manned space flight launch processing environment.

Manuka Honey: A Case Study of Severe Atopic Eczematous Dermatitis Reaction to Henna Tattoo.

PubMed

Harrison, Jeanine

Many mainstream medications were derived from plants and originally utilized in patient management well prior to the extensive research and testing processes of current pharmaceutical standards. The evolution of therapeutic management within the pharmaceutical and skin care industry often uses synthetic processing of products with less of a focus on the natural ingredients from which they were originally derived. However, more recently there has been a shift in pharmacological management to include the therapeutic use of more holistic medicines and practices and thus a broadening of the uses of nontraditional medical treatment options. This has been seen in the use of treatments, such as Manuka honey, for skin conditions and dermal injuries. It is often with off-label uses, or conditions resistant to other treatments, that then prompt the use of holistic products and the true value of the product is validated. As with the following case study, the example of the use of Manuka honey on a severe atopic contact dermatitis eczematous reaction provides further documentation and supportive evidence of the potential efficacy of the properties of this particular natural product.

10 CFR 1707.203 - Filing requirements for demands or requests for documents or testimony.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Filing requirements for demands or requests for documents... Production of Documents § 1707.203 Filing requirements for demands or requests for documents or testimony. You must comply with the following requirements whenever you issue demands or requests to a DNFSB...

Preparation guide for class B software specification documents

NASA Technical Reports Server (NTRS)

Tausworthe, R. C.

1979-01-01

General conceptual requirements and specific application rules and procedures are provided for the production of software specification documents in conformance with deep space network software standards and class B standards. Class B documentation is identified as the appropriate level applicable to implementation, sustaining engineering, and operational uses by qualified personnel. Special characteristics of class B documents are defined.

New perspectives for leishmaniasis chemotherapy over current anti-leishmanial drugs: a patent landscape.

PubMed

Machado-Silva, Alice; Guimarães, Pedro Pires Goulart; Tavares, Carlos Alberto Pereira; Sinisterra, Rubén Dario

2015-03-01

Although leishmaniasis is estimated to cause the ninth largest disease burden among individual infectious diseases, it is still one of the most neglected diseases in terms of drug development. Current drugs are highly toxic, resistance is common and compliance of patients to treatment is low, as treatment is long and drug price is high. In this review, the authors carried out a patent landscape in search for new perspectives for leishmaniasis therapy. This search encompassed patent documents having priority date between 1994 and 2014. Selected compounds were compared to current anti-leishmanial drugs regarding efficacy and toxicity, when experimental data were available. Most patents related to drugs for leishmaniasis have not been produced by the pharmaceutical industry but rather by public research institutes or by universities, and the majority of the inventions disclosed are still in preclinical phase. There is an urgent need to find new ways of funding research for leishmaniasis drugs, incentivizing product development partnerships and pushing forward innovation.

Satellite Ocean Data Tools in the high school classroom.

NASA Astrophysics Data System (ADS)

Tweedie, M.; Snyder, H. D.

2007-12-01

The NASA-sponsored Ocean Motion website (http://www.oceanmotion.org) documents the story of humankind's interest in and observations of surface currents from the early seafaring Polynesians to present day satellite observations. Ocean surface current patterns impact our lives through their influences on the weather, climate, commerce, natural disasters and sea life. The Ocean Motion web site provides inquiry based, classroom ready materials for high school teachers and students to study ocean surface currents. In addition to the information resources posted on the website, there are also investigations that lead students to explore patterns and relationships through data products (color- coded map images, time series graphs and data tables). These investigations are done through an interactive browser interface that provides access to a wealth of oceanography data. This presentation focuses on use of surface current data and models in student investigations to illustrate application of basic science principles found in high school science curriculum. Skills developed using data to discover patterns and relationships will serve students in other courses as well as empower them to become stewards of the Earths environment.

Systems engineering interfaces: A model based approach

NASA Astrophysics Data System (ADS)

Fosse, E.; Delp, C. L.

The engineering of interfaces is a critical function of the discipline of Systems Engineering. Included in interface engineering are instances of interaction. Interfaces provide the specifications of the relevant properties of a system or component that can be connected to other systems or components while instances of interaction are identified in order to specify the actual integration to other systems or components. Current Systems Engineering practices rely on a variety of documents and diagrams to describe interface specifications and instances of interaction. The SysML[1] specification provides a precise model based representation for interfaces and interface instance integration. This paper will describe interface engineering as implemented by the Operations Revitalization Task using SysML, starting with a generic case and culminating with a focus on a Flight System to Ground Interaction. The reusability of the interface engineering approach presented as well as its extensibility to more complex interfaces and interactions will be shown. Model-derived tables will support the case studies shown and are examples of model-based documentation products.

76 FR 28444 - Agency Information Collection Activities: Form G-884, Extension of a Currently Approved...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-17

... Original Documents; OMB Control No. 1615-0100. The Department of Homeland Security, U.S. Citizenship and...: Request for the Return of Original Documents. (3) Agency form number, if any, and the applicable component... person is eligible to obtain original document(s) contained in an alien file. (5) An estimate of the...

43 CFR 3835.31 - When do I file an annual FLPMA document?

Code of Federal Regulations, 2013 CFR

2013-10-01

... MAINTENANCE FEES Annual FLPMA Documents § 3835.31 When do I file an annual FLPMA document? (a) If you must... because you located the claim during the current assessment year or because BLM has deferred assessment... FLPMA document filing. You must state in the notice of intent to hold either that BLM has deferred the...

43 CFR 3835.31 - When do I file an annual FLPMA document?

Code of Federal Regulations, 2012 CFR

2012-10-01

... MAINTENANCE FEES Annual FLPMA Documents § 3835.31 When do I file an annual FLPMA document? (a) If you must... because you located the claim during the current assessment year or because BLM has deferred assessment... FLPMA document filing. You must state in the notice of intent to hold either that BLM has deferred the...

43 CFR 3835.31 - When do I file an annual FLPMA document?

Code of Federal Regulations, 2011 CFR

2011-10-01

... MAINTENANCE FEES Annual FLPMA Documents § 3835.31 When do I file an annual FLPMA document? (a) If you must... because you located the claim during the current assessment year or because BLM has deferred assessment... FLPMA document filing. You must state in the notice of intent to hold either that BLM has deferred the...

43 CFR 3835.31 - When do I file an annual FLPMA document?

Code of Federal Regulations, 2014 CFR

2014-10-01

... MAINTENANCE FEES Annual FLPMA Documents § 3835.31 When do I file an annual FLPMA document? (a) If you must... because you located the claim during the current assessment year or because BLM has deferred assessment... FLPMA document filing. You must state in the notice of intent to hold either that BLM has deferred the...

World energy projection system: Model documentation

NASA Astrophysics Data System (ADS)

1992-06-01

The World Energy Project System (WEPS) is an accounting framework that incorporates projects from independently documented models and assumptions about the future energy intensity of economic activity (ratios of total energy consumption divided by gross domestic product) and about the rate of incremental energy requirements met by hydropower, geothermal, coal, and natural gas to produce projections of world energy consumption published annually by the Energy Information Administration (EIA) in the International Energy Outlook (IEO). Two independently documented models presented in Figure 1, the Oil Market Simulation (OMS) model and the World Integrated Nuclear Evaluation System (WINES), provide projections of oil and nuclear power consumption published in the IEO. Output from a third independently documented model, and the International Coal Trade Model (ICTM), is not published in the IEO but is used in WEPS as a supply check on projections of world coal consumption produced by WEPS and published in the IEO. A WEPS model of natural gas production documented in this report provides the same type of implicit supply check on the WEPS projections of world natural gas consumption published in the IEO. Two additional models are included in Figure 1, the OPEC Capacity model and the Non-OPEC Oil Production model. These WEPS models provide inputs to the OMS model and are documented in this report.

Recommendations and Justifications To Remove Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Field Office Federal Facility Agreement and Consent Order, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Birney, Cathleen; Krauss, Mark J

This document is part of an effort to reevaluate 37 FFACO and Administrative URs against the current Soils Risk-Based Corrective Action Evaluation Process. After reviewing 37 existing FFACO and Administrative URs, 3 URs addressed in this document have sufficient information to determine that these current URs may be removed, based on the RBCA criteria. This document presents recommendations on modifications to existing URs that will be consistent with the RBCA criteria.

Tebuconazole dissipation and metabolism in Tifton loamy sand during laboratory incubationt.

PubMed

Strickland, Timothy C; Potter, Thomas L; Joo, Hyun

2004-07-01

The fungicide tebuconazole is widely used to control soil-borne and foliar diseases in peanuts and other crops. No published data are currently available on the extent and rate at which this compound degrades in soil. Unpublished data summarized in registration documents suggest that the compound is persistent, with 300-600 days half-life. We conducted a 63-day laboratory incubation to evaluate tebuconazole's dissipation kinetics and impact on soil microbial activity in Tifton loamy sand. Tifton soils support extensive peanut production in the Atlantic Coastal Plain region of Georgia and Alabama. Products containing tebuconazole are applied to an estimated 50% of the peanut acreage in the region. At the end of the incubation, 43 (+/-42)% of the parent compound was recovered in soil extracts. The first-order kinetic model, which gave a good fit to the dissipation data (r2 = 0.857), yielded a soil half-life (t1/2) of 49 days. This is 6-12 times more rapid than t1/2 values described in unpublished tebuconazole registration documents. Four degradates were identified. Tentative structural assignments indicated that degradates were derived from hydroxylation of the parent compound and/or chlorophenyl ring cleavage. Cleavage products showed a steady increase during the incubation, and on a molar basis were equal to 63% of the time zero tebuconazole concentration. No significant effect on soil microbial biomass was observed, indicating that when the compound is applied at normal agronomic rate it does not impact soil metabolic activity. Use of the soil-half life data derived in this study should improve the accuracy oftebuconazole fate assessments for Coastal Plain peanut production. The study also indicated that environmental assessment of selected degradates may be needed to fully evaluate risks of tebuconazole use.

A Compositional Relevance Model for Adaptive Information Retrieval

NASA Technical Reports Server (NTRS)

Mathe, Nathalie; Chen, James; Lu, Henry, Jr. (Technical Monitor)

1994-01-01

There is a growing need for rapid and effective access to information in large electronic documentation systems. Access can be facilitated if information relevant in the current problem solving context can be automatically supplied to the user. This includes information relevant to particular user profiles, tasks being performed, and problems being solved. However most of this knowledge on contextual relevance is not found within the contents of documents, and current hypermedia tools do not provide any easy mechanism to let users add this knowledge to their documents. We propose a compositional relevance network to automatically acquire the context in which previous information was found relevant. The model records information on the relevance of references based on user feedback for specific queries and contexts. It also generalizes such information to derive relevant references for similar queries and contexts. This model lets users filter information by context of relevance, build personalized views of documents over time, and share their views with other users. It also applies to any type of multimedia information. Compared to other approaches, it is less costly and doesn't require any a priori statistical computation, nor an extended training period. It is currently being implemented into the Computer Integrated Documentation system which enables integration of various technical documents in a hypertext framework.

CALiPER Report 23: Photometric Testing of White Tunable LED Luminaires

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

2016-01-01

This report documents an initial investigation of photometric testing procedures for white-tunable LED luminaires and summarizes the key features of those products. Goals of the study include understanding the amount of testing required to characterize a white-tunable product, and documenting the performance of available color-tunable luminaires that are intended for architectural lighting.

National projections of forest and rangeland condition indicators: a supporting technical document for the 1999 RPA assessment.

Treesearch

John Hof; Curtis Flather; Tony Baltic; Stephen Davies

1999-01-01

The 1999 forest and rangeland condition indicator model is a set of independent econometric production functions for environmental outputs (measured with condition indicators) at the national scale. This report documents the development of the database and the statistical estimation required by this particular production structure with emphasis on two special...

15 CFR 30.10 - Retention of export information and the authority to require production of documents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Retention of export information and the authority to require production of documents. 30.10 Section 30.10 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS, DEPARTMENT OF COMMERCE FOREIGN TRADE...

Adapting a Methodology from Mathematics Education Research to Chemistry Education Research: Documenting Collective Activity

ERIC Educational Resources Information Center

Cole, Renee; Becker, Nicole; Towns, Marcy; Sweeney, George; Wawro, Megan; Rasmussen, Chris

2012-01-01

In this report, we adapt and extend a methodology for documenting the collective production of meaning in a classroom community. A cornerstone of the methodological approach that we develop is a close examination of classroom discourse. Our efforts to analyze the collective production of meaning by examining classroom interaction are compatible…

Compliance Timeline, Compliance Options, and Required Notifications for Surface Coating of Wood Building Products National Emission Standards for Hazardous Air Pollutants (NESHAP)

EPA Pesticide Factsheets

This January 2005 document contains a diagram of dates and events for compliance with the NESHAP for surface coating of wood building products. Also on this page is a January 2005 document with flow charts to demonstrate compliance options for the NESHAP

36 CFR 703.18 - Procedures when an employee's appearance is demanded or documents are demanded.

Code of Federal Regulations, 2012 CFR

2012-07-01

... LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.18 Procedures... is being, as the case may be, referred for the prompt consideration of the appropriate Library or...

36 CFR § 703.18 - Procedures when an employee's appearance is demanded or documents are demanded.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.18 Procedures... is being, as the case may be, referred for the prompt consideration of the appropriate Library or...

36 CFR 703.18 - Procedures when an employee's appearance is demanded or documents are demanded.

Code of Federal Regulations, 2011 CFR

2011-07-01

... LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.18 Procedures... is being, as the case may be, referred for the prompt consideration of the appropriate Library or...

36 CFR 703.18 - Procedures when an employee's appearance is demanded or documents are demanded.

Code of Federal Regulations, 2014 CFR

2014-07-01

... LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library Is Not a Party § 703.18 Procedures... is being, as the case may be, referred for the prompt consideration of the appropriate Library or...

75 FR 42315 - Third Party Testing for Certain Children's Products; Carpets and Rugs: Requirements for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-21

... samples that are identical in all material respects to the product. The Commission also emphasizes that... Small Carpets and Rugs (FF 2-70). A true copy, in English, of the accreditation and scope documents... status must submit to the Commission copies, in English, of their training documents showing how...

24 CFR 2004.22 - Filing requirements for demands or requests for documents or testimony.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Filing requirements for demands or... AND URBAN DEVELOPMENT SUBPOENAS AND PRODUCTION IN RESPONSE TO SUBPOENAS OR DEMANDS OF COURTS OR OTHER AUTHORITIES Requests for Testimony and Production of Documents § 2004.22 Filing requirements for demands or...

24 CFR 2004.22 - Filing requirements for demands or requests for documents or testimony.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Filing requirements for demands or... AND URBAN DEVELOPMENT SUBPOENAS AND PRODUCTION IN RESPONSE TO SUBPOENAS OR DEMANDS OF COURTS OR OTHER AUTHORITIES Requests for Testimony and Production of Documents § 2004.22 Filing requirements for demands or...

11 CFR 9409.5 - Procedures for demand for testimony or production of documents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 11 Federal Elections 1 2010-01-01 2010-01-01 false Procedures for demand for testimony or... § 9409.5 Procedures for demand for testimony or production of documents. (a) A demand directed to the... New York Avenue, NW., Suite 1100, Washington, DC 20005. Acceptance of a demand shall not constitute an...

7 CFR 1423.6 - Financial information documentation requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... CORPORATION APPROVED WAREHOUSES § 1423.6 Financial information documentation requirements. To be approved under this part, a warehouse operator shall submit a current financial statement at the time of... 7 Agriculture 10 2010-01-01 2010-01-01 false Financial information documentation requirements...

Substance use disorders in Arab countries: research activity and bibliometric analysis

PubMed Central

2014-01-01

Background Substance use disorders, which include substance abuse and substance dependence, are present in all regions of the world including Middle Eastern Arab countries. Bibliometric analysis is an increasingly used tool for research assessment. The main objective of this study was to assess research productivity in the field of substance use disorders in Arab countries using bibliometric indicators. Methodology Original or review research articles authored or co-authored by investigators from Arab countries about substance use disorders during the period 1900 – 2013 were retrieved using the ISI Web of Science database. Research activity was assessed by analyzing the annual research productivity, contribution of each Arab country, names of journals, citations, and types of abused substances. Results Four hundred and thirteen documents in substance use disorders were retrieved. Annual research productivity was low but showed a significant increase in the last few years. In terms of quantity, Kingdom of Saudi Arabia (83 documents) ranked first in research about substance use disorders while Lebanon (17.4 documents per million) ranked first in terms of number of documents published per million inhabitants. Retrieved documents were found in different journal titles and categories, mostly in Drug and Alcohol Dependence Journal. Authors from USA appeared in 117 documents published by investigators from Arab countries. Citation analysis of retrieved documents showed that the average citation per document was 10.76 and the h - index was 35. The majority of retrieved documents were about tobacco and smoking (175 documents) field while alcohol consumption and abuse research was the least with 69 documents. Conclusion The results obtained suggest that research in this field was largely neglected in the past. However, recent research interest was observed. Research output on tobacco and smoking was relatively high compared to other substances of abuse like illicit drugs and medicinal agents. Governmental funding for academics and mental health graduate programs to do research in the field of substance use disorders is highly recommended. PMID:25148888

Agricultural Capacity to Increase the Production of Select Fruits and Vegetables in the US: A Geospatial Modeling Analysis.

PubMed

Conrad, Zach; Peters, Christian J; Chui, Kenneth; Jahns, Lisa; Griffin, Timothy S

2017-09-23

The capacity of US agriculture to increase the output of specific foods to accommodate increased demand is not well documented. This research uses geospatial modeling to examine the capacity of the US agricultural landbase to increase the per capita availability of an example set of nutrient-dense fruits and vegetables. These fruits and vegetables were selected based on nutrient content and an increasing trend of domestic production and consumption. Geographic information system models were parameterized to identify agricultural land areas meeting crop-specific growing requirements for monthly precipitation and temperature; soil depth and type; cropland availability; and proximity to existing production centers. The results of these analyses demonstrate that crop production can be expanded by nearly 144,000 ha within existing national production centers, generating an additional 0.05 cup-equivalents of fruits and vegetables per capita per day, representing a 1.7% increase above current total F&V availability. Expanding the size of national crop production centers can further increase the availability of all F&V by 2.5%-5.4%, which is still less than the recommended amount. Challenges to increasing F&V production in the US include lack of labor availability, barriers to adoption among producers, and threats to crop yields from environmental concerns.

Agricultural Capacity to Increase the Production of Select Fruits and Vegetables in the US: A Geospatial Modeling Analysis

PubMed Central

Peters, Christian J.; Chui, Kenneth; Jahns, Lisa; Griffin, Timothy S.

2017-01-01

The capacity of US agriculture to increase the output of specific foods to accommodate increased demand is not well documented. This research uses geospatial modeling to examine the capacity of the US agricultural landbase to increase the per capita availability of an example set of nutrient-dense fruits and vegetables. These fruits and vegetables were selected based on nutrient content and an increasing trend of domestic production and consumption. Geographic information system models were parameterized to identify agricultural land areas meeting crop-specific growing requirements for monthly precipitation and temperature; soil depth and type; cropland availability; and proximity to existing production centers. The results of these analyses demonstrate that crop production can be expanded by nearly 144,000 ha within existing national production centers, generating an additional 0.05 cup-equivalents of fruits and vegetables per capita per day, representing a 1.7% increase above current total F&V availability. Expanding the size of national crop production centers can further increase the availability of all F&V by 2.5%–5.4%, which is still less than the recommended amount. Challenges to increasing F&V production in the US include lack of labor availability, barriers to adoption among producers, and threats to crop yields from environmental concerns. PMID:28946618

Regulatory concerns in the development of biologic-biomaterial combinations. United States Food and Drug Administration.

PubMed

Chapekar, M S

1996-01-01

Several biologic-biomaterial combinations are currently under development in an attempt to modulate tissue or organ function in patients. The FDA regulations on combination products and the intercenter agreements among the Center for Biologics Evaluation and Research (CBER), the Center for Devices and Radiological Health (CDRH), and the Center for Drugs Evaluation and Research (CDER) provide further guidance on center jurisdiction of combination products and other products where there are jurisdictional concerns. The biological component of biologic-biomaterial combinations raises a number of issues that relate to the safety and bioactivity of the final product. For example, transmission of adventitious agents to patients via somatic cells, tissue, or cell-derived products is a major safety concern as are in vivo inflammatory responses elicited by the biomaterial component. CBER has drafted a number of "Points to Consider" documents to provide further guidance in the development of biological products. The intent of this article is to provide the highlights of the FDA regulations for combination products and the intercenter agreement between CBER and CDRH delineating the responsibilities of each center for medical device activities. In addition, the article focuses on the CBER's concerns related to the development of somatic cell-biomaterial combinations for therapeutic use.

Dynamic Gate Product and Artifact Generation from System Models

NASA Technical Reports Server (NTRS)

Jackson, Maddalena; Delp, Christopher; Bindschadler, Duane; Sarrel, Marc; Wollaeger, Ryan; Lam, Doris

2011-01-01

Model Based Systems Engineering (MBSE) is gaining acceptance as a way to formalize systems engineering practice through the use of models. The traditional method of producing and managing a plethora of disjointed documents and presentations ("Power-Point Engineering") has proven both costly and limiting as a means to manage the complex and sophisticated specifications of modern space systems. We have developed a tool and method to produce sophisticated artifacts as views and by-products of integrated models, allowing us to minimize the practice of "Power-Point Engineering" from model-based projects and demonstrate the ability of MBSE to work within and supersede traditional engineering practices. This paper describes how we have created and successfully used model-based document generation techniques to extract paper artifacts from complex SysML and UML models in support of successful project reviews. Use of formal SysML and UML models for architecture and system design enables production of review documents, textual artifacts, and analyses that are consistent with one-another and require virtually no labor-intensive maintenance across small-scale design changes and multiple authors. This effort thus enables approaches that focus more on rigorous engineering work and less on "PowerPoint engineering" and production of paper-based documents or their "office-productivity" file equivalents.

5 CFR 1631.4 - Public reference facilities and current index.

Code of Federal Regulations, 2012 CFR

2012-01-01

... located in room 4308 at 1250 H Street, NW., Washington, DC. Reading area hours are from 9:00 A.M. to 5:00 P.M., Monday through Friday, exclusive of Federal holidays. Electronic reading room documents are...), including documents published by the Board in the Federal Register which are currently in effect. (b) The...

5 CFR 1631.4 - Public reference facilities and current index.

Code of Federal Regulations, 2011 CFR

2011-01-01

... located in room 4308 at 1250 H Street, NW., Washington, DC. Reading area hours are from 9:00 A.M. to 5:00 P.M., Monday through Friday, exclusive of Federal holidays. Electronic reading room documents are...), including documents published by the Board in the Federal Register which are currently in effect. (b) The...

[Cases of poisoning in Germany. Disease entity, documentation, and aspects of the event].

PubMed

Hahn, A; Begemann, K; Stürer, A

2014-06-01

Cases of poisoning account for a distinct share of accidents in Germany, which is particularly high for accidents involving children. Cases of poisoning resulting from suicidal intent or abuse are not counted as accidents. Compared to other cases of disease and accidents, the numerical documentation of cases of poisoning is inadequate. Presently, there is no institution in Germany that could make available representative and meaningful data on the current state of poisoning. Owing to intensive scientific cooperation between the poison information centers (funded by the federal states) and the Poison and Product Documentation Center at the Federal Institute for Risk Assessment (BfR DocCenter) as well as to international cooperation, harmonized and standardized tools have been developed for the appropriate documentation and reporting of procedures to account for poisoning accidents. The first evaluation for 2005-2012 based on published and processed figures for the Federal Republic of Germany yielded the following results: Of approximately 230,000 telephone inquiries received in 2012, about 207,000 involved exposure of humans to different noxae. An annual increase of 3-5 % was recorded. For 2011, analyses of subsets processed by means of standardized methods yielded the following results: Medicines were involved in about 39 % of the cases recorded (of these, medicinal products for humans in 99 %); chemical/physicochemical agents in about 26 % (of these, cleaning and maintenance products in 46 %); products of daily use in about 14 % (of these, cosmetics in 40 %); and plants in about 10 %. More than 90 % of cases were acute poisoning and less than 5 %, chronic poisoning. Regarding the degree of severity of poisoning, an asymptomatic course was reported for 44 % of the cases; minor manifestations were experienced in 30 %, moderate ones in 6 %, and severe manifestations in 2 % of the cases recorded. Fatal cases were rare (< 0.1 %). The majority of cases (67 %) were caused by poisoning accidents, followed by suicidal action (20 %), with abuse and industrial poisoning (4 %) in third position; 1 % of the cases of poisoning were attributed to adverse drug reactions (ADR) and mistaking a medicinal product for another one. Infants aged 1-2 years have the highest risk of poisoning. A panel of the BfR Committee for the Assessment of Poisonings has already developed proposals for a national monitoring scheme of poisoning incidents. The aim is to prepare annual reports similar to the report of the National Poison Data System (NPDS) maintained by the American Association of Poison Control Centers (AAPCC) in the USA.

12 CFR 1209.29 - Discovery.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the timely, cost-effective management of document discovery (including, if applicable, electronically... discovery plan shall specify the form of electronic productions, if any. Documents are to be produced in... proceeding under this part may obtain document discovery by serving upon any other party in the proceeding a...

12 CFR 1209.29 - Discovery.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the timely, cost-effective management of document discovery (including, if applicable, electronically... discovery plan shall specify the form of electronic productions, if any. Documents are to be produced in... proceeding under this part may obtain document discovery by serving upon any other party in the proceeding a...

12 CFR 1209.29 - Discovery.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the timely, cost-effective management of document discovery (including, if applicable, electronically... discovery plan shall specify the form of electronic productions, if any. Documents are to be produced in... proceeding under this part may obtain document discovery by serving upon any other party in the proceeding a...

27 CFR 24.110 - Organizational documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Organizational documents..., DEPARTMENT OF THE TREASURY LIQUORS WINE Establishment and Operations Application § 24.110 Organizational documents. The supporting information required by paragraph (c) of § 24.109, includes, as applicable, copies...

Digital development of products with NX9 for academical areas

NASA Astrophysics Data System (ADS)

Goanta, A. M.

2015-11-01

International competitiveness forced the manufacturing enterprises to look for new ways to accelerate the development of digital products through innovation, global alliances and strategic partnerships. In an environment of global research and development of distributed geographically, all members of the joint teams made up of companies and universities need to access updated and accurate information about products created by any of the type employed, student, teacher. Current design processes involve more complex products consisting of elements of design created by multiple teams, disciplines and suppliers using independent CAD systems. Even when using a 3D CAD mature technology, many companies fail to significantly reduce losses in the process, improve product quality or product type to ensure successful innovations to market arouse interest. These challenges require a radical rethinking of the business model, which belongs to the field of design, which must be based on digital development of products based on integrated files. Through this work, the author has proposed to provide both synthesis and transformations brought news of the integrated NX [1, 2, 3] from Siemens PLM Software 9, following a news results detailed documentary study, and personal results obtained by applying the same version, the digital and integrated development of a product type device test beams. Based on educational license received for NX 9 was made a detailed study of the innovations made by this release, and the application of some of them went to graphical modelling and getting all the documentation of a test device bearing beams. Also, were synthesized in terms of methodology, the steps to take to obtain graphical documentation. The results consist of: 3D models of all parts and assembly 3D model of the three-dimensional constraints of all component parts and not least respectively all drawings and assembly drawing. The most important consequence of the paper is the obtaining of integrated files that can be subjected to further analysis type CAE / CAM / PDM software components by the same company. Additional advantages related files by the synthesis of integrated CAD / CAE / CAM / PDM.

Heterogeneous Chemistry Involving Methanol in Tropospheric Clouds

NASA Technical Reports Server (NTRS)

Tabazadeh, A.; Yokelson, R. J.; Singh, H. B.; Hobbs, P. V.; Crawford, J. H.; Iraci, L. T.

2004-01-01

In this report we analyze airborne measurements to suggest that methanol in biomass burning smoke is lost heterogeneously in clouds. When a smoke plume intersected a cumulus cloud during the SAFARI 2000 field project, the observed methanol gas phase concentration rapidly declined. Current understanding of gas and aqueous phase chemistry cannot explain the loss of methanol documented by these measurements. Two plausible heterogeneous reactions are proposed to explain the observed simultaneous loss and production of methanol and formaldehyde, respectively. If the rapid heterogeneous processing of methanol, seen in a cloud impacted by smoke, occurs in more pristine clouds, it could affect the oxidizing capacity of the troposphere on a global scale.

Process to Produce Iron Nanoparticle Lunar Dust Simulant Composite

NASA Technical Reports Server (NTRS)

Hung, Ching-cheh; McNatt, Jeremiah

2010-01-01

A document discusses a method for producing nanophase iron lunar dust composite simulant by heating a mixture of carbon black and current lunar simulant types (mixed oxide including iron oxide) at a high temperature to reduce ionic iron into elemental iron. The product is a chemically modified lunar simulant that can be attracted by a magnet, and has a surface layer with an iron concentration that is increased during the reaction. The iron was found to be -iron and Fe3O4 nanoparticles. The simulant produced with this method contains iron nanoparticles not available previously, and they are stable in ambient air. These nanoparticles can be mass-produced simply.

Fundamentals of carbon dioxide-enhanced oil recovery (CO2-EOR): a supporting document of the assessment methodology for hydrocarbon recovery using CO2-EOR associated with carbon sequestration

USGS Publications Warehouse

Verma, Mahendra K.

2015-01-01

The objective of this report is to provide basic technical information regarding the CO2-EOR process, which is at the core of the assessment methodology, to estimate the technically recoverable oil within the fields of the identified sedimentary basins of the United States. Emphasis is on CO2-EOR because this is currently one technology being considered as an ultimate long-term geologic storage solution for CO2 owing to its economic profitability from incremental oil production offsetting the cost of carbon sequestration.