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Sample records for doe model conference

  1. 1988 DOE model conference proceedings: Volume 4

    SciTech Connect

    Not Available

    1988-01-01

    These Proceedings of the October 3-7, 1988, DOE Model Conference are a compilation of the papers that were presented in the technical or poster sessions at the conference. Papers and posters not submitted for publication are not included in the Proceedings. The Table of Contents lists the titles of papers as well as the names of the presenters. These individuals are not, in all cases, the primary authors of the papers published. The actual title pages, appearing later with the papers, show the primary author(s) and all co-authors. The papers in all three volumes of the Proceedings appear as they were originally submitted for publication and have not been edited or changed in any way. Topics discussed in Volume 4 include site characterization and remediation projects, environmental monitoring and modeling; disposal site selection and facility design, risk assessment, safety and health issues, and site remediation technology.

  2. 1988 DOE model conference proceedings: Volume 5

    SciTech Connect

    Not Available

    1988-01-01

    These Proceedings of the October 3--7, 1988 DOE Model Conference are a compilation of the papers that were presented in the technical or poster sessions at the conference papers and posters not submitted for publication are not included in the Proceedings. The Table of Contents lists the titles of papers as well as the names of the presenters. These individuals are not, in all cases, the primary authors of the papers published. The actual title pages, appearing later with the papers, show the primary author(s) and all co-authors. The papers in all three volumes of the Proceedings appear as they were originally submitted for publication and have not been edited or changed in any way. Topics discussed in Volume 5 include environmental assessments and program strategies, waste treatment technologies, and regulations and compliance studies.

  3. 1988 DOE model conference proceedings: Volume 1

    SciTech Connect

    Not Available

    1988-01-01

    These Proceedings of the October 3-7, 1988, DOE Model Conference are a compilation of the papers that were presented in the technical or poster sessions at the conference. Papers and posters not submitted for publication are not included in the Proceedings. The Table of Contents lists the titles of papers as well as the names of the presenters. These individuals are not, in all cases, the primary authors of the papers published. The actual title pages, appearing later with the papers, show the primary author(s) and all co-authors. The papers in all three volumes of the Proceedings appear as they were originally submitted for publication and have not been edited or changed in any way. Topics included in Volume 1 are Environmental Data Management, Site characterization technology, Wastewater treatment, Waste management in foreign countries, Transuranic waste management, and Groundwater characterization and treatment.

  4. 1988 DOE model conference proceedings: Volume 3

    SciTech Connect

    Not Available

    1988-01-01

    These Proceedings of the October 3 - 7, 1988, DOE Model Conference are a compilation of the papers that were presented in the technical or poster sessions at the conference. Papers and posters not submitted for publication are not included in the Proceedings. The Table of Contents lists the titles of papers as well as the names of the presenters. These individuals are not, in all cases, the primary authors of the papers published. The actual title pages, appearing later with the papers, show the primary author(s) and all co-authors. The papers in all three volumes of the proceedings appear as they were originally submitted for publication and have not been edited or changed in any way. Topics included in Volume 3 include treatment of soils, waste characterization and certification, waste minimization site remediation management plans and programs, and training programs.

  5. DOE model conference on waste management and environmental restoration

    SciTech Connect

    Not Available

    1990-01-01

    Reports dealing with current topics in waste management and environmental restoration were presented at this conference in six sessions. Session 1 covered the Hot Topics'' including regulations and risk assessment. Session 2 dealt with waste reduction and minimization; session 3 dealt with waste treatment and disposal. Session 4 covered site characterization and analysis. Environmental restoration and associated technologies wee discussed in session 5 and 6. Individual papers have been cataloged separately.

  6. DOE Workshop at Tapia Conference

    SciTech Connect

    Taylor, Valerie

    2015-02-19

    The DE-SC0013568 DOE Grant, in the amount of $11,822.79, was used to support five doctoral students from underrepresented groups to attend the 2015 Richard Tapia Celebration of Diversity in Computing Conference, held February 18-21 in Boston, MA. Each scholarship was approximately $1200 to cover conference registration, travel, and lodging for the duration of the conference. The remaining $5,822.79 was used to support a DOE Breakfast Workshop during breakfast on Thursday, February 19. The Breakfast supported approximately 140 graduate students from underrepresented groups to learn about the different career opportunities at the different DOE National Laboratories.

  7. Fifteenth DOE solar photochemistry research conference

    SciTech Connect

    Not Available

    1991-01-01

    This is a compilation of abstracts from the Fifteenth DOE Solar Photochemistry Research Conference hosted by the Solar Energy Research Institute which took place June 2--6, 1991. A large variety of topics pertinent to solar energy conversion are covered, including photoinduced electron transfer, photochemical energy conversion, and photosynthetic energy conversion. (GHH)

  8. DOE Workshop; Pan-Gass Conference on the Representation of Atmospheric Processes in Weather and Climate Models

    SciTech Connect

    Morrison, PI Hugh

    2012-09-21

    This is the first meeting of the whole new GEWEX (Global Energy and Water Cycle Experiment) Atmospheric System Study (GASS) project that has been formed from the merger of the GEWEX Cloud System Study (GCSS) Project and the GEWEX Atmospheric Boundary Layer Studies (GABLS). As such, this meeting will play a major role in energizing GEWEX work in the area of atmospheric parameterizations of clouds, convection, stable boundary layers, and aerosol-cloud interactions for the numerical models used for weather and climate projections at both global and regional scales. The representation of these processes in models is crucial to GEWEX goals of improved prediction of the energy and water cycles at both weather and climate timescales. This proposal seeks funds to be used to cover incidental and travel expenses for U.S.-based graduate students and early career scientists (i.e., within 5 years of receiving their highest degree). We anticipate using DOE funding to support 5-10 people. We will advertise the availability of these funds by providing a box to check for interested participants on the online workshop registration form. We will also send a note to our participants' mailing lists reminding them that the funds are available and asking senior scientists to encourage their more junior colleagues to participate. All meeting participants are encouraged to submit abstracts for oral or poster presentations. The science organizing committee (see below) will base funding decisions on the relevance and quality of these abstracts, with preference given to under-represented populations (especially women and minorities) and to early career scientists being actively mentored at the meeting (e.g. students or postdocs attending the meeting with their advisor).

  9. Proceedings of the Seventeenth DOE Solar Photochemistry Research Conference

    NASA Astrophysics Data System (ADS)

    The Seventeenth DOE Solar Photochemistry Research Conference sponsored by the Division of Chemical Sciences, Office of Basic Energy Sciences, is being held June 6-10, 1993, at Cragun's Lodge and Conference Center, Brainerd, Minnesota The meeting is hosted this year by the Ames Laboratory of Iowa State University. The purpose of the meeting is to foster cooperation, collaboration, and exchange of current research ideas among grantees and contractors of the DOE Division of Chemical Sciences engaged in fundamental research on solar photochemical energy conversion. This conference provides a special opportunity for interaction among investigators from diverse traditional chemistry disciplines who share the common good of providing the knowledge and concepts needed for production of low cost fuels and chemicals or electricity by photochemical conversion of solar energy. Our special guest plenary lecturer is Professor Graham Fleming, of the University of Chicago, who will speak on ultrafast spectroscopic studies of molecular dynamics in the condensed phase. The remaining presentations on Monday will feature further investigations of ultrafast phenomena in solvation, electron transfer, and charge separation at interfaces. These will lead into the topical sessions which follow on photosynthesis, molecular models, photoinduced charge transfer in homogeneous and heterogeneous solutions, inorganic photochemistry, and photoelectrochemistry. As an added feature, the photoelectrochemistry session will include six short introductory lectures for the benefit of nonspecialists on outstanding issues and problems in that field. In this volume may be found a copy of the program, the abstracts of 28 formal presentations and 59 posters, as well as an address listing of the 114 participants.

  10. Proceedings of the Seventeenth DOE Solar Photochemistry Research Conference

    SciTech Connect

    Not Available

    1993-12-31

    The Seventeenth DOE Solar Photochemistry Research Conference sponsored by the Division of Chemical Sciences, Office of Basic Energy Sciences, is being held June 6--10, 1993, at Cragun`s Lodge and Conference Center, Brainerd, Minnesota The meeting is hosted this year by the Ames Laboratory of Iowa State University. The purpose of the meeting is to foster cooperation, collaboration, and exchange of current research ideas among grantees and contractors of the DOE Division of Chemical Sciences engaged in fundamental research on solar photochemical energy conversion. This conference provides a special opportunity for interaction among investigators from diverse traditional chemistry disciplines who share the common good of providing the knowledge and concepts needed for production of low cost fuels and chemicals or electricity by photochemical conversion of solar energy. Our special guest plenary lecturer is Professor Graham Fleming, of the University of Chicago, who will speak on ultrafast spectroscopic studies of molecular dynamics in the condensed phase. The remaining presentations on Monday will feature further investigations of ultrafast phenomena in solvation, electron transfer, and charge separation at interfaces. These will lead into the topical sessions which follow on photosynthesis, molecular models, photoinduced charge transfer in homogeneous and heterogeneous solutions, inorganic photochemistry, and photoelectrochemistry. As an added feature, the photoelectrochemistry session will include six short introductory lectures for the benefit of nonspecialists on outstanding issues and problems in that field. In this volume may be found a copy of the program, the abstracts of 28 formal presentations and 59 posters, as well as an address listing of the 114 participants.

  11. Proceedings of the 1992 DOE-industry thermal distribution conference

    SciTech Connect

    Andrews, J.W.

    1992-06-01

    The subject of the conference was thermal distribution in small buildings. Thermal distribution systems are the ductwork, piping, or other means used to transport heat or cooling effect from the equipment in which the heat or cooling is produced to the building spaces in which it is used. The small buildings category is defined to include single-family residential and multifamily and commercial buildings with less than 10,000 ft{sup 2} floor area. The 1992 DOE-Industry Thermal Distribution Conference was conceived as the beginning of a process of information transfer between the DOE and the industries having a stake in thermal distribution systems, whereby the DOE can make the industry aware of its thinking and planned directions early enough for changes to be made, and whereby the industries represented can provide this input to the DOE on a timely and informed basis. In accordance with this, the objectives of the Conference were: To present--to a representative group of researchers and industry representative--the current industry thinking and DOE`s current directions for research in small-building thermal distribution. To obtain from industry and the research community a critique of the DOE priorities and additional ideas concerning how DOE can best assist the industry in promoting energy conservation in thermal distribution systems.

  12. Proceedings of the 1992 DOE-industry thermal distribution conference

    SciTech Connect

    Andrews, J.W.

    1992-06-01

    The subject of the conference was thermal distribution in small buildings. Thermal distribution systems are the ductwork, piping, or other means used to transport heat or cooling effect from the equipment in which the heat or cooling is produced to the building spaces in which it is used. The small buildings category is defined to include single-family residential and multifamily and commercial buildings with less than 10,000 ft{sup 2} floor area. The 1992 DOE-Industry Thermal Distribution Conference was conceived as the beginning of a process of information transfer between the DOE and the industries having a stake in thermal distribution systems, whereby the DOE can make the industry aware of its thinking and planned directions early enough for changes to be made, and whereby the industries represented can provide this input to the DOE on a timely and informed basis. In accordance with this, the objectives of the Conference were: To present--to a representative group of researchers and industry representative--the current industry thinking and DOE's current directions for research in small-building thermal distribution. To obtain from industry and the research community a critique of the DOE priorities and additional ideas concerning how DOE can best assist the industry in promoting energy conservation in thermal distribution systems.

  13. Proceedings of the Nineteenth DOE Solar Photochemistry Research Conference

    SciTech Connect

    1995-07-01

    This document is a compilation of reports presented at the Nineteenth DOE Solar Photochemistry Research Conference. Sessions included photophysical properties of transition metal complexes, cage effects on photochemistry, charge transfer, photo-induced charge separation in biomimetic molecules, photosynthesis, and electron transfer.

  14. Fourth DOE Natural Phenomena Hazards Mitigation Conference: Proceedings. Volume 1

    SciTech Connect

    Not Available

    1993-12-31

    This conference allowed an interchange in the natural phenomena area among designers, safety professionals, and managers. The papers presented in Volume I of the proceedings are from sessions I - VIII which cover the general topics of: DOE standards, lessons learned and walkdowns, wind, waste tanks, ground motion, testing and materials, probabilistic seismic hazards, risk assessment, base isolation and energy dissipation, and lifelines and floods. Individual papers are indexed separately. (GH)

  15. 1987 Oak Ridge model conference: Proceedings

    SciTech Connect

    Not Available

    1987-10-01

    A conference sponsored by the United States Department of Energy (DOE), was held on waste management. Topics included waste management, site remediation, waste minimization, economic and social aspects of waste management, and waste management training. Several case studies of US DOE facilities are included. Individual projects are processed separately for the data bases. (CBS)

  16. Proceedings of the Eighteenth DOE Solar Photochemistry Research Conference

    NASA Astrophysics Data System (ADS)

    This annual conference brings together grantees and contractors of the DOE Division of Chemical Sciences engaged in fundamental research on solar photochemical energy conversion. It provides a focus for a wide spectrum of activities which contribute to providing the knowledge base and concepts needed for the capture and chemical conversion of solar energy. The research will provide the foundations for solar technologies of the future, in which light-induced charge separation processes will be applied to conversion of light energy to chemical energy, e.g., production of alcohols from CO2, H2 from water, NH3 from atm. N2, etc. The plenary lecture addresses photoconversion by nanocrystalline films of oxide semiconductors. The topical sessions feature presentations on charge transfer at semiconductor-liquid electrolyte junctions, long-range vectorial electron transfer in macromolecular arrays, transition metal photophysics, electronic structure and solvent effects on electron transfer processes, artificial assemblies for photosynthesis, and the photosynthetic bacterial reaction center. This volume contains the agenda for the meeting and abstracts of the 30 formal presentations and 56 posters.

  17. Proceedings of the Eighteenth DOE Solar Photochemistry Research Conference

    SciTech Connect

    Not Available

    1994-07-01

    This annual conference brings together grantees and contractorsof the DOE Division of Chemical Sciences engaged in fundamental research on solar photochemical energy conversion. It provides a focus for a wide spectrum of activities which contribute to providing the knowledge base and concepts needed for the capture and chemical conversion of solar energy. The research will provide the foundations for solar technologies of the future, in which light-induced charge separation processes will be applied to conversion of light energy to chemical energy, e.g., production of alcohols from CO{sub 2}, H{sup 2} from water, NH{sub 3} from atm. N{sub 2}, etc. The plenary lecture addresses photoconversion by nanocrystalline films of oxide semiconductors. The topical sessions feature presentations on charge transfer at semiconductor-liquid electrolyte junctions, long-range vectorial electron transfer in macromolecular arrays, transition metal photophysics, electronic structure and solvent effects on electron transfer processes, artifical assemblies for photosynthesis, and the photosynthetic bacterial reaction center. This volume contains the agenda for the meeting and abstracts of the 30 formal presentations and 56 posters.

  18. The Conference Facilitator Model: Improving the Value of Conference Attendance for Attendees and the Organization.

    PubMed

    Nebrig, Dawn; Munafo, Jennifer; Goddard, Julie; Tierney, Carol

    2015-09-01

    Healthcare leaders face a multitude of priorities demanding their attention and resources, from patient, employee safety and hospital-acquired conditions to predicting future revenue in the context of healthcare reform. Assessing value requires balancing outcomes and experience with cost. How does allocating funds for professional nursing conferences measure up? What is a valid return on investment when we send staff nurses to professional conferences, specifically the annual Magnet® conference? The following article describes how Cincinnati Children's Hospital Medical Center answered these questions and redefined the expectations for conference attendees while enhancing the experience and the reportable outcomes for practice and the organization.

  19. The Conference Facilitator Model: Improving the Value of Conference Attendance for Attendees and the Organization.

    PubMed

    Nebrig, Dawn; Munafo, Jennifer; Goddard, Julie; Tierney, Carol

    2015-09-01

    Healthcare leaders face a multitude of priorities demanding their attention and resources, from patient, employee safety and hospital-acquired conditions to predicting future revenue in the context of healthcare reform. Assessing value requires balancing outcomes and experience with cost. How does allocating funds for professional nursing conferences measure up? What is a valid return on investment when we send staff nurses to professional conferences, specifically the annual Magnet® conference? The following article describes how Cincinnati Children's Hospital Medical Center answered these questions and redefined the expectations for conference attendees while enhancing the experience and the reportable outcomes for practice and the organization. PMID:26247321

  20. The 2009 National Environmental Public Health Conference: One Model for Planning Green and Healthy Conferences

    PubMed Central

    Ruckart, Perri Zeitz; Moore, Cory; Burgin, Deborah; Byrne, Maggie Kelly

    2011-01-01

    The Centers for Disease Control and Prevention's National Center for Environmental Health and the Agency for Toxic Substances and Disease Registry committed to making their 2009 National Environmental Public Health Conference a model for green and healthy conferences. The conference included increased opportunities for physical activity, both as part of conference events and for transportation to the conference. In addition, conference meals were healthy and sustainably sourced. The conference also implemented intuitive, accessible recycling; online scheduling and evaluation to minimize hard-copy materials; and the purchase of carbon offsets to reduce the unwanted environmental impact of the conference. Public health professionals have an opportunity and obligation to support healthy behaviors at their events and to serve as leaders in this area. Facilitating healthy and sustainable choices is in alignment with goals for both public health and broader social issues—such as environmental quality—that have a direct bearing on public health. PMID:21563713

  1. Twelfth annual US DOE low-level waste management conference

    SciTech Connect

    Not Available

    1990-01-01

    The papers in this document comprise the proceedings of the Department of Energy's Twelfth Annual Low-Level Radioactive Waste Management Conference, which was held in Chicago, Illinois, on August 28 and 29, 1990. General subjects addressed during the conference included: mixed waste, low-level radioactive waste tracking and transportation, public involvement, performance assessment, waste stabilization, financial assurance, waste minimization, licensing and environmental documentation, below-regulatory-concern waste, low-level radioactive waste temporary storage, current challenges, and challenges beyond 1990.

  2. 77 FR 4808 - Conference on Air Quality Modeling

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... AGENCY Conference on Air Quality Modeling AGENCY: U.S. Environmental Protection Agency (EPA). ACTION: Notice of conference. SUMMARY: The EPA will be hosting the Tenth Conference on Air Quality Modeling on...; suggest alternatives and substitute language for your requested changes. Describe any assumptions...

  3. Proceedings of the Fourteenth DOE solar photochemistry research conference

    SciTech Connect

    Not Available

    1989-01-01

    The central themes of this year's Solar Photochemistry Research Conference encompassed initial charge separation in photosynthesis, photoinduced charge separation in other organized assemblies, electron transfer, organic and inorganic photochemistry, and photoelectrochemistry. This volume contains a copy of the program the abstracts of 29 formal presentations and 47 posters, a record of the discussion following each presentation, and an address list for the 96 attendees. Individual projects are processed separately for the databases. .

  4. EPRI-DOE Conference on Environmentally-Enhanced Hydropower Turbines: Technical Papers

    SciTech Connect

    None, None

    2011-12-01

    The EPRI-DOE Conference on Environmentally-Enhanced Hydropower Turbines was a component of a larger project. The goal of the overall project was to conduct the final developmental engineering required to advance the commercialization of the Alden turbine. As part of this effort, the conference provided a venue to disseminate information on the status of the Alden turbine technology as well as the status of other advanced turbines and research on environmentally-friendly hydropower turbines. The conference was also a product of a federal Memorandum of Understanding among DOE, USBR, and USACE to share technical information on hydropower. The conference was held in Washington, DC on May 19 and 20, 2011 and welcomed over 100 attendees. The Conference Organizing Committee included the federal agencies with a vested interest in hydropower in the U.S. The Committee collaboratively assembled this conference, including topics from each facet of the environmentally-friendly conventional hydropower research community. The conference was successful in illustrating the readiness of environmentally-enhanced hydropower technologies. Furthermore, the topics presented illustrated the need for additional deployment and field testing of these technologies in an effort to promote the growth of environmentally sustainable hydropower in the U.S. and around the world.

  5. Proceedings of the 21st DOE/NRC nuclear air cleaning conference; Volume 2, Sessions 9--16

    SciTech Connect

    First, M.W.

    1991-02-01

    The 21st meeting of the Department of Energy/Nuclear Regulatory Commission (DOE/NRC) Nuclear Air Cleaning Conference was held in San Diego, CA on August 13--16, 1990. The proceedings have been published as a two volume set. Volume 2 contains sessions covering adsorbents, nuclear codes and standards, modelling, filters, safety, containment venting and a review of nuclear air cleaning programs around the world. Also included is the list of attendees and an index of authors and speakers. (MHB)

  6. Proceedings of the Sixteenth DOE Solar Photochemistry Research Conference

    NASA Astrophysics Data System (ADS)

    The conference brings together contractors and grantees engaged in research on photochemical energy conversion to foster cooperation, collaboration, and exchange of current research ideas. The meeting provides an opportunity for cross-fertilization and synergistic interaction among investigators who share common long-range goals of producing low-cost fuels and chemicals or electricity by photochemical conversion of solar energy. The program this year encompassed the topical areas of transition metal photochemistry and photophysics, electron transfer, photosynthesis, photoelectrochemistry, organic photochemistry, and photoredox chemistry in heterogeneous environments. This volume contains the agenda for the meeting, abstracts of 30 formal presentations and 54 posters, a record of question/answer discussions, as well as the participant list and an author index.

  7. Proceedings of the 1984 DOE nuclear reactor and facility safety conference. Volume II

    SciTech Connect

    Not Available

    1984-01-01

    This report is a collection of papers on reactor safety. The report takes the form of proceedings from the 1984 DOE Nuclear Reactor and Facility Safety Conference, Volume II of two. These proceedings cover Safety, Accidents, Training, Task/Job Analysis, Robotics and the Engineering Aspects of Man/Safety interfaces.

  8. A Theoretical Model for the Associative Nature of Conference Participation

    PubMed Central

    Smiljanić, Jelena; Chatterjee, Arnab; Kauppinen, Tomi; Mitrović Dankulov, Marija

    2016-01-01

    Participation in conferences is an important part of every scientific career. Conferences provide an opportunity for a fast dissemination of latest results, discussion and exchange of ideas, and broadening of scientists’ collaboration network. The decision to participate in a conference depends on several factors like the location, cost, popularity of keynote speakers, and the scientist’s association with the community. Here we discuss and formulate the problem of discovering how a scientist’s previous participation affects her/his future participations in the same conference series. We develop a stochastic model to examine scientists’ participation patterns in conferences and compare our model with data from six conferences across various scientific fields and communities. Our model shows that the probability for a scientist to participate in a given conference series strongly depends on the balance between the number of participations and non-participations during his/her early connections with the community. An active participation in a conference series strengthens the scientist’s association with that particular conference community and thus increases the probability of future participations. PMID:26859404

  9. Modeling, Simulation, and Gaming: Student Capstone Conference

    NASA Technical Reports Server (NTRS)

    Banks, Catherine

    2008-01-01

    Highlights student research and student projects focused on MS&G. Competitive presentations - Volunteer judges from industry, government, military and academic institutions across America. - Evaluate research, presentation expertise, . and ability to answer questions. - Judges also facilitate their assigned conference tracks

  10. Twenty-third DOE/NRC Nuclear Air Cleaning and Treatment Conference

    SciTech Connect

    Bellamy, R.R.; Hayes, J.J.; First, M.W.

    1995-03-24

    This paper presents the details of the Nuclear Air Cleaning and Treatment Conference held in Buffalo, New York during July 1994. Topics discussed include: nuclear air cleaning codes and standards; waste disposal; particulate filter developments; sampling and monitoring of process and effluent streams; off-gasses from fuel reprocessing; adsorbents and adsorption; accident control and analysis; revised source terms for power plant accidents; and the highlight of the conference concerned operations at the West Valley DOE facility where construction is underway to solidify radioactive wastes.

  11. 25 CFR 900.154 - How does an Indian tribe or tribal organization request an informal conference?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... an informal conference? The Indian tribe or tribal organization shall file its request for an... 25 Indians 2 2010-04-01 2010-04-01 false How does an Indian tribe or tribal organization request an informal conference? 900.154 Section 900.154 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF...

  12. Community-Partnered Research Conference Model: The Experience of Community Partners in Care Study

    PubMed Central

    Khodyakov, Dmitry; Pulido, Esmeralda; Ramos, Ana; Dixon, Elizabeth

    2013-01-01

    The Problem Conducting community-partnered research conferences is a powerful yet underutilized approach to translating research into practice and improving result dissemination and intervention sustainability strategies. Nonetheless, detailed descriptions of conference features and ways to use them in empirical research are rare. Purpose of Article We describe how community-partnered conferences may be integrated into research projects by using an example of Community Partners in Care, a large cluster-randomized controlled trial that uses Community Partnered Participatory Research principles. Key Points Our conceptual model illustrates the role community-partnered research conferences may play in three study phases and describes how different conference features may increase community engagement, build two-way capacity, and ensure equal project ownership. Conclusion(s) As the number of community-partnered studies grows, so too does the need for practical tools to support this work. Community-partnered research conferences may be effectively employed in translational research to increase two-way capacity-building and promote long-term intervention success. PMID:24859106

  13. 1987 Oak Ridge model conference: Proceedings: Volume 2, Environmental protection

    SciTech Connect

    Not Available

    1987-01-01

    See the abstract for Volume I for general information on the conference. Topics discussed in Volume II include data management techiques for environmental protection efforts, the use of models in environmental auditing, in emergency plans, chemical accident emergency response, risk assessment, monitoring of waste sites, air and water monitoring of waste sites, and in training programs. (TEM)

  14. Parent representation model in child safety conferences.

    PubMed

    Lalayants, Marina

    2013-01-01

    Child welfare-involved parents are often isolated and lack support and skills to navigate complex systems. Programs using a parent representation service model in child protection can offer an exceptional and critical form of support and empowerment to birthparents, promote parental engagement and cooperation, and teach system navigation skills. While there is a notable emphasis on an overall family-centered and strength-based approach in child welfare, much progress is still needed in giving voice to parents, empowering them, including them in decisionmaking about the case, and seeking their cooperation. Funding should be directed to recruiting more parent representatives to assist birthparents in their communities as well to educating and training child protective services workers by transferring values and strategies implemented by parent representatives. Although additional research is certainly necessary, it appears that programs such as the Child Welfare Organizing Project in New York City may be an important step toward building partnerships with families impacted by the child welfare system in promoting child safety, well-being, and permanency. PMID:24923137

  15. Whole chromosome gain does not in itself confer cancer-like chromosomal instability

    PubMed Central

    Valind, Anders; Jin, Yuesheng; Baldetorp, Bo; Gisselsson, David

    2013-01-01

    Constitutional aneuploidy is typically caused by a single-event meiotic or early mitotic error. In contrast, somatic aneuploidy, found mainly in neoplastic tissue, is attributed to continuous chromosomal instability. More debated as a cause of aneuploidy is aneuploidy itself; that is, whether aneuploidy per se causes chromosomal instability, for example, in patients with inborn aneuploidy. We have addressed this issue by quantifying the level of somatic mosaicism, a proxy marker of chromosomal instability, in patients with constitutional aneuploidy by precise background-filtered dual-color FISH. In contrast to previous studies that used less precise methods, we find that constitutional trisomy, even for large chromosomes that are often trisomic in cancer, does not confer a significantly elevated rate of somatic chromosomal mosaicism in individual cases. Constitutional triploidy was associated with an increased level of somatic mosaicism, but this consisted mostly of reversion from trisomy to disomy and did not correspond to a proportionally elevated level of chromosome mis-segregation in triploids, indicating that the observed mosaicism resulted from a specific accumulation of cells with a hypotriploid chromosome number. In no case did the rate of somatic mosaicism in constitutional aneuploidy exceed that of “chromosomally stable” cancer cells. Our findings show that even though constitutional aneuploidy was in some cases associated with low-level somatic mosaicism, it was insufficient to generate the cancer-like levels expected if aneuploidy single-handedly triggered cancer-like chromosomal instability. PMID:24324169

  16. Bridging Research, Practice, and Policy: The "Evidence Academy" Conference Model.

    PubMed

    Rohweder, Catherine L; Laping, Jane L; Diehl, Sandra J; Moore, Alexis A; Isler, Malika Roman; Scott, Jennifer Elissa; Enga, Zoe Kaori; Black, Molly C; Dave, Gaurav; Corbie-Smith, Giselle; Melvin, Cathy L

    2016-01-01

    Innovative models to facilitate more rapid uptake of research findings into practice are urgently needed. Community members who engage in research can accelerate this process by acting as adoption agents. We implemented an Evidence Academy conference model bringing together researchers, health care professionals, advocates, and policy makers across North Carolina to discuss high-impact, life-saving study results. The overall goal is to develop dissemination and implementation strategies for translating evidence into practice and policy. Each 1-day, single-theme, regional meeting focuses on a leading community-identified health priority. The model capitalizes on the power of diverse local networks to encourage broad, common awareness of new research findings. Furthermore, it emphasizes critical reflection and active group discussion on how to incorporate new evidence within and across organizations, health care systems, and communities. During the concluding session, participants are asked to articulate action plans relevant to their individual interests, work setting, or area of expertise.

  17. Student-Led Parent Conferences: A Model for Teaching Responsibility.

    ERIC Educational Resources Information Center

    Guyton, Jane M.; Fielstein, Lynda L.

    1989-01-01

    Describes program in which elementary school students lead parent-teacher conferences, shares authors' experiences with the student-led conferences, and discusses how the process has fostered student responsibility. Describes results of informal study that support the student-led conference. (NB)

  18. ICCK Conference Final Report

    SciTech Connect

    Green, William H.

    2013-05-28

    The 7th International Conference on Chemical Kinetics (ICCK) was held July 10-14, 2011, at Massachusetts Institute of Technology (MIT), in Cambridge, MA, hosted by Prof. William H. Green of MIT's Chemical Engineering department. This cross-disciplinary meeting highlighted the importance of fundamental understanding of elementary reactions to the full range of chemical investigations. The specific conference focus was on elementary-step kinetics in both the gas phase and in condensed phase. The meeting provided a unique opportunity to discuss how the same reactive species and reaction motifs manifest under very different reaction conditions (e.g. atmospheric, aqueous, combustion, plasma, in nonaqueous solvents, on surfaces.). The conference featured special sessions on new/improved experimental techniques, improved models and data analysis for interpreting complicated kinetics, computational kinetics (especially rate estimates for large kinetic models), and a panel discussion on how the community should document/archive kinetic data. In the past, this conference had been limited to homogeneous gas-phase and liquid-phase systems. This conference included studies of heterogeneous kinetics which provide rate constants for, or insight into, elementary reaction steps. This Grant from DOE BES covered about half of the subsidies we provided to students and postdocs who attended the conference, by charging them reduced-rate registration fees. The complete list of subsidies provided are listed in Table 1 below. This DOE funding was essential to making the conference affordable to graduate students, and indeed the attendance at this conference was higher than at previous conferences in this series. Donations made by companies provided additional subsidies, leveraging the DOE funding. The conference was very effective in educating graduate students and important in fostering scientific interactions, particularly between scientists studying gas phase and liquid phase kinetics

  19. Thirteenth annual U.S. DOE low-level radioactive waste management conference: Proceedings

    SciTech Connect

    1991-12-31

    The 40 papers in this document comprise the proceedings of the Department of Energy`s Thirteenth Annual Low-Level Radioactive Waste Management Conference that was held in Atlanta, Georgia, on November 19--21, 1991. General subjects addressed during the conference included: disposal facility design; greater-than-class C low-level waste; public acceptance considerations; waste certification; site characterization; performance assessment; licensing and documentation; emerging low-level waste technologies; waste minimization; mixed waste; tracking and transportation; storage; and regulatory changes. Papers have been processed separately for inclusion on the data base.

  20. Twenty-ninth ORNL/DOE conference on analytical chemistry in energy technology. Abstracts of papers

    SciTech Connect

    Not Available

    1986-01-01

    This booklet contains separate abstracts of 55 individual papers presented at this conference. Different sections in the book are titled as follows: laser techniques; resonance ionization spectroscopy; laser applications; new developments in mass spectrometry; analytical chemistry of hazardous waste; and automation and data management. (PLG)

  1. Development of a Conference Planning Model Using Integrated Database, Word Processing, and Spreadsheet Software.

    ERIC Educational Resources Information Center

    Stevens, William E.

    This report presents a model for conducting a statewide conference for the approximately 900 members of the South Carolina Council of Teachers of Mathematics (SCCTM) using the AppleWorks integrated software as the basis of the implementation plan. The first and second chapters provide background information on the conference and the…

  2. Proceedings of the First All-USGS Modeling Conference, November 14-17, 2005

    USGS Publications Warehouse

    Frondorf, Anne

    2007-01-01

    Preface: The First All-USGS Modeling Conference was held November 14-17, 2005, in Port Angeles, Washington. U.S. Geological Survey (USGS) participants at the conference came from USGS headquarters and all USGS regions and represented all four science disciplines-Biology, Geography, Geology, and Water. The conference centered on selected oral case study presentations and posters on current USGS scientific modeling capabilities and activities. Abstracts for these case study presentations and posters are presented here. On behalf of all the participants of the First All-USGS Modeling Conference, we appreciate the support of Dee Ann Nelson and the staff of the Olympic Park Institute in providing the conference facilities; Dr. Jerry Freilich and Dr. Brian Winter of the National Park Service, Olympic National Park, for organizing and leading the conference field trip; and Debra Becker and Amy Newman, USGS Western Fisheries Research Center, Seattle, Washington, and Tammy Hansel, USGS Geospatial Information Office, Reston, Virginia, for providing technical support for the conference. The organizing committee for the conference included Jenifer Bracewell, Jacoby Carter, Jeff Duda, Anne Frondorf, Linda Gundersen, Tom Gunther, Pat Jellison, Rama Kotra, George Leavesley, and Doug Muchoney.

  3. Using a Consensus Conference to Characterize Regulatory Concerns Regarding Bioremediation of Radionuclides and Heavy Metals in Mixed Wastes at DOE Sites

    SciTech Connect

    Lach, Denise

    2005-06-01

    We have spent this first part of the project preparing background material for conference participants and making arrangements for the conference itself. Material regarding state regulatory constraints to the use of bioremediation in the cleanup of radionuclides and heavy metals at DOE sites around the country has been added to the Bioremediation Briefing paper for participants. The Steering Committee has been formulated and will hold their first meeting via phone conference on Monday, September 13, 2005. On the agenda is identification of conference participants, experts, and initial issues likely to be addressed. Human Subjects approval has been secured from the University. The ''pre-test'' has been developed and is ready to implement. The Consensus Conference will be held in Phoenix, AZ during January and February 2005; we are working with the Chamber of Commerce to find an appropriate site.

  4. DOE Commercial Building Benchmark Models: Preprint

    SciTech Connect

    Torcelini, P.; Deru, M.; Griffith, B.; Benne, K.; Halverson, M.; Winiarski, D.; Crawley, D. B.

    2008-07-01

    To provide a consistent baseline of comparison and save time conducting such simulations, the U.S. Department of Energy (DOE) has developed a set of standard benchmark building models. This paper will provide an executive summary overview of these benchmark buildings, and how they can save building analysts valuable time. Fully documented and implemented to use with the EnergyPlus energy simulation program, the benchmark models are publicly available and new versions will be created to maintain compatibility with new releases of EnergyPlus. The benchmark buildings will form the basis for research on specific building technologies, energy code development, appliance standards, and measurement of progress toward DOE energy goals. Having a common starting point allows us to better share and compare research results and move forward to make more energy efficient buildings.

  5. Proceedings of the Modeling Evidence in HPV Pre-Conference Workshop

    PubMed Central

    Craig, Benjamin M.; Brisson, Marc; Chesson, Harrell; Giuliano, Anna R.; Jit, Mark; Moffitt, H. Lee

    2013-01-01

    All published and active HPV modelers from around the world were invited to Malmo, Sweden for the inaugural Modeling Evidence in HPV (MEHPV) Pre-Conference Workshop, May 9 and 10, 2009. This workshop—held for the 2 days preceding the 25th International Papillomavirus Conference—provided a unique opportunity for open discussion on HPV modeling and the related scientific and methodological issues. From over a dozen countries and a variety of settings, 34 participants (representing 82% of the HPV modeling literature) exchanged ideas on the field’s fundamental questions. The proceedings, based on the 217-page transcript, was assembled by the Scientific Committee for the explicit purpose of objectively summarizing these ideas in a de-identified, readable fashion. It represents the work and opinions of session participants as recorded and does not constitute official positions of the participants as a whole or individually, the scientific committee, or any sponsoring organization or entity. Through transparency and broad dissemination, this introspective proceedings further characterizes prominent, contemporaneous issues in the state of HPV modeling. PMID:20728767

  6. 1987 Oak Ridge model conference: Proceedings: Volume I, Part 3, Waste Management

    SciTech Connect

    Not Available

    1987-01-01

    A conference sponsored by the United States Department of Energy (DOE), was held on waste management. Topics of discussion were transuranic waste management, chemical and physical treatment technologies, waste minimization, land disposal technology and characterization and analysis. Individual projects are processed separately for the data bases. (CBS)

  7. 1987 Oak Ridge model conference: Proceedings: Volume I, Part 2, Waste Management

    SciTech Connect

    Not Available

    1987-01-01

    A conference sponsored by the United States Department of Energy (DOE) was held on Waste Mangement. Topics discussed were waste stabilization technologies regulations and standards, innovative treatment technology, waste stabilization projects. Individual projects are processed separately for the data bases. (CBS)

  8. PREFACE: MCWASP XIV: International Conference on Modelling of Casting, Welding and Advanced Solidification Processes

    NASA Astrophysics Data System (ADS)

    Yasuda, H.

    2015-06-01

    The current volume represents contributed papers of the proceedings of the 14th international conference on ''Modeling of Casting, Welding and Advanced Solidification Processes (MCWASP XIV)'', Yumebutai International Conference Center, Awaji island, Hyogo, Japan on 21 - 26 June, 2016. The first conference of the series 'Modeling of Casting, Welding and Advanced Solidification Processes (MCWASP)' was started up in 1980, and this is the 14th conference. The participants are more than 100 scientists from industry and academia, coming from 19 countries. In the conference, we have 5 invited, 70 oral and 31 poster presentations on different aspects of the modeling. The conference deals with various casting processes (Ingot / shape casting, continuous casting, direct chill casting and welding), fundamental phenomena (nucleation and growth, dendritic growth, eutectic growth, micro-, meso- and macrostructure formation and defect formation), coupling problems (electromagnetic interactions, application of ultrasonic wave), development of experimental / computational methods and so on. This volume presents the cutting-edge research in the modeling of casting, welding and solidification processes. I would like to thank MAGMA Giessereitechnologie GmbH, Germany and SCSK Corporation, Japan for supporting the publication of contributed papers. Hideyuki Yasuda Conference Chairman Department of Materials Science and Engineering, Kyoto University Japan

  9. AGU Chapman Conference Hydrogeologic Processes: Building and Testing Atomistic- to Basin-Scale Models

    SciTech Connect

    Weaver, B.

    1994-12-31

    This report presents details of the Chapman Conference given on June 6--9, 1994 in Lincoln, New Hampshire. This conference covered the scale of processes involved in coupled hydrogeologic mass transport and a concept of modeling and testing from the atomistic- to the basin- scale. Other topics include; the testing of fundamental atomic level parameterizations in the laboratory and field studies of fluid flow and mass transport and the next generation of hydrogeologic models. Individual papers from this conference are processed separately for the database.

  10. Research and Development on Heat Pumps for Space Conditioning Applications: Proceedings of the DOE/ORNL Heat Pump Conference

    NASA Astrophysics Data System (ADS)

    Jacobs, V. A.; Powell, R. H., Jr.

    1985-08-01

    This conference was planned to provide information on current activities in the US Department of Energy (DOE) and Oak Ridge National Laboratory (ORNL) Building Equipment Research (BER) Program. It was primarily for the benefit of HVAC equipment manufacturers and other interested parties, including utilities, independent research and development organizations, universities, other government groups, and research funding and management organizations. The technical presentations were grouped into two principal subject areas: electric systems and thermally activated systems. Electric-system topics included field performance studies, laboratory experiments on cycling performance, analytical estimates of the benefits of variable capacity and zone control, nonazeotropic refrigerant mixtures, ground-coupled systems, and an analysis of Stirling-cycle heat pumps. In the area of thermally activated heat pumps, presentations centered on the development of absorption systems, Stirling-engine-driven systems, and a linear, free-piston IC-engine compressor. Separate abstracts have been prepared for 27 presentations for inclusion in the Energy Data Base.

  11. Proceedings of the twenty-first DOE solar photochemistry research conference

    SciTech Connect

    1997-06-01

    The Solar Photochemistry Research Conference brings together grantees and contractors of the Division of Chemical Sciences who are engaged in fundamental research on solar photochemical energy conversion. The annual conference provides a focus for the program by allowing for the exchange of new information and ideas, identification of needs and opportunities, and fostering of collaborations among investigators of disparate chemistry backgrounds. The synergy that has been achieved is a major strength of the program. The research provides the foundations for future solar technologies, in which light-induced charge separation processes will be applied to conversion of light energy to chemical energy, e.g., production of alcohols from carbon dioxide, hydrogen from water, ammonia from atmospheric nitrogen, or other needed chemicals at lower cost of by using sunlight as the energy source. The program includes topical sessions on semiconductor nanoparticles, nanocrystalline films, and photoinduced charge separation at the semiconductor/liquid interface; photochemistry and photophysics of transition metal complexes; photoinduced charge separation in zeolites and lamellar assemblies; intramolecular charge separation and electron transfer; dynamics of solvation and solution interfaces; and photoconversion via porphyrins and biomimetic constructs. The special guest plenary lecturer is Professor Moungi Bawendi of the Massachusetts Institute of Technology, who spoke on semiconductor nanocrystallites (quantum dots). As an added feature, Tom Surek, the Photovoltaics Technology program manager at NREL, presented a status report on one of the most promising and heavily supported programs in solar energy conversion technology, solid state photovoltaics. This volume contains the agenda for the meeting, abstracts of the 31 formal presentations and 55 posters, as well as an address list for the 111 participants.

  12. Participation in action: the Healthy African American Families community conference model.

    PubMed

    Jones, Loretta; Collins, Barry E

    2010-01-01

    The Healthy African American Families project (HAAF) in Los Angeles developed "community conferences" as a method of engaging local community members in mutually beneficial participatory collaborations with academic and clinical researchers. In these conferences, community voices and concerns about a health issue are translated into the language of scientific inquiry. Scientific information and process are translated into forms that can be understood and utilized by the lay community. Equally important, the conference process enables community members to provide input into scientific projects and to take ownership of subsequent interventions resulting from the research conducted in its community. The HAAF conference model is participation in action. It may be useful for other communities engaging in community participatory prevention research. PMID:20629242

  13. 2012 Community Earth System Model (CESM) Tutorial - Proposal to DOE

    SciTech Connect

    Holland, Marika; Bailey, David A

    2013-03-18

    The Community Earth System Model (CESM) is a fully-coupled, global climate model that provides state-of-the-art computer simulations of the Earth's past, present, and future climate states. This document provides the agenda and list of participants for the conference. Web materials for all lectures and practical sessions available from: http://www.cesm.ucar.edu/events/tutorials/073012/ .

  14. Proceedings of the 21st DOE/NRC Nuclear Air Cleaning Conference; Sessions 1--8

    SciTech Connect

    First, M.W.

    1991-02-01

    Separate abstracts have been prepared for the papers presented at the meeting on nuclear facility air cleaning technology in the following specific areas of interest: air cleaning technologies for the management and disposal of radioactive wastes; Canadian waste management program; radiological health effects models for nuclear power plant accident consequence analysis; filter testing; US standard codes on nuclear air and gas treatment; European community nuclear codes and standards; chemical processing off-gas cleaning; incineration and vitrification; adsorbents; nuclear codes and standards; mathematical modeling techniques; filter technology; safety; containment system venting; and nuclear air cleaning programs around the world. (MB)

  15. Why Does ADHD Confer Risk for Cigarette Smoking? A Review of Psychosocial Mechanisms

    ERIC Educational Resources Information Center

    Glass, Kerrie; Flory, Kate

    2010-01-01

    Research has documented that adolescents and young adults with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for cigarette smoking, but less attention has examined why this risk exists. The current paper reviews the literature on different psychosocial mechanisms [self-medication hypothesis, social factors (social modeling,…

  16. ASM Conference on Prokaryotic Development

    SciTech Connect

    Kaplan, H. B.

    2005-07-13

    Support was provided by DOE for the 2nd ASM Conference on Prokaryotic Development. The final conference program and abstracts book is attached. The conference presentations are organized around topics that are central to the current research areas in prokaryotic development. The program starts with topics that involve relatively simple models systems and ends with systems that are more complex. The topics are: i) the cell cycle, ii) the cytoskeleton, iii) morphogenesis, iv) developmental transcription, v) signaling, vi) multicellularity, and vii) developmental diversity and symbiosis. The best-studied prokaryotic development model systems will be highlighted at the conference through research presentations by leaders in the field. Many of these systems are also model systems of relevance to the DOE mission including carbon sequestration (Bradyrizobium, Synechococcus), energy production (Anabaena, Rhodobacter) and bioremediation (Caulobacter, Mesorhizobium). In addition, many of the highlighted organisms have important practical applications; the actinomycetes and myxobacteria produce antimicrobials that are of commercial interest. It is certain that the cutting-edge science presented at the conference will be applicable to the large group of bacteria relevant to the DOE mission.

  17. League of Our Own: Creating a Model United Nations Scrimmage Conference

    ERIC Educational Resources Information Center

    Ripley, Brian; Carter, Neal; Grove, Andrea K.

    2009-01-01

    Model United Nations (MUN) provides a great forum for students to learn about global issues and political processes, while also practicing communication and negotiation skills that will serve them well for a lifetime. Intercollegiate MUN conferences can be problematic, however, in terms of logistics, budgets, and student participation. In order to…

  18. Adelante, Mujer Hispana: A Conference Model for Hispanic Women. Pamphlet 20.

    ERIC Educational Resources Information Center

    Women's Bureau (DOL), Washington, DC.

    The model is based on the highly successful first Women's Bureau sponsored Colorado Education and Employment Conference for Hispanic Women ("Adelante, Mujer Hispana") held in January 1980 for low-income women seeking employment and employed women seeking better jobs and upward mobility. It is intended for use by groups and individuals in planning…

  19. Participation in Action: The Healthy African American Families Community Conference Model

    PubMed Central

    Jones, Loretta; Collins, Barry E.

    2013-01-01

    The Healthy African American Families project (HAAF) in Los Angeles developed “community conferences” as a method of engaging local community members in mutually beneficial participatory collaborations with academic and clinical researchers. In these conferences, community voices and concerns about a health issue are translated into the language of scientific inquiry. Scientific information and process are translated into forms that can be understood and utilized by the lay community. Equally important, the conference process enables community members to provide input into scientific projects and to take ownership of subsequent interventions resulting from the research conducted in its community. The HAAF conference model is participation in action. It may be useful for other communities engaging in community participatory prevention research. PMID:20629242

  20. Models for Excellence in Second Language Education: Dimension 2003. Selected Proceedings of the 2003 Joint Conference of the Southern Conference on Language Teaching and the Foreign Language Association of Georgia

    ERIC Educational Resources Information Center

    Cherry, C. Maurice, Ed.; Bradley, Lee, Ed.

    2003-01-01

    "Dimension" is the annual volume containing the selected, refereed, edited proceedings of each year's conference. By selecting "Models for Excellence in Second Language Education" as the 2003 conference theme, the Board of Directors of the Southern Conference on Language Teaching (SCOLT) demonstrated an eagerness to invite presentations…

  1. Does ambroxol confer a protective effect on the lungs in patients undergoing cardiac surgery or having lung resection?

    PubMed

    Wang, Shaohua; Huang, Dayu; Ma, Qinyun; Chen, Xiaofeng

    2014-06-01

    A best evidence topic in perioperative care was written according to a structured protocol. The question addressed was 'Does ambroxol confer a protective effect on the lung in patients undergoing cardiac surgery or having lung resection?' A total of 247 papers were found using the reported search, of which 7 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers were tabulated. Several studies indicate that for patients with chronic obstructive pulmonary disease (COPD) who undergo cardiac surgery or upper abdominal surgery, perioperative ambroxol administration is associated with improved pulmonary function and reduced postoperative pulmonary complications (PPCs). In patients with pulmonary lobectomy, large-dose ambroxol treatment (1000 mg/day for 3 days) is correlated with reduced PPCs (6 vs 19%, P = 0.02), decreased postoperative hospital stay (5.6 vs 8.1 days, P = 0.02) and lower postoperative cost (2499 vs 5254 €, P = 0.04) compared with low-dose ambroxol treatment. Ambroxol also has a protective effect on the lungs during extracorporeal bypass, ameliorating inflammatory reaction and oxygen stress and preserving pulmonary surfactant. However, there is no evidence for any advantage of reducing PPCs after extracorporeal circulation. We conclude that perioperative application of ambroxol, a versatile mucoactive drug, particularly in high doses, is associated with lower PPCs, especially in high-risk patients with fundamental lung disease such as COPD. Large doses of ambroxol are correlated with even lower PPCs after lung resection. We recommend that routine intravenous ambroxol should be used in large doses in high-risk patients in the perioperative period to reduce the risk of PPCs.

  2. Does ambroxol confer a protective effect on the lungs in patients undergoing cardiac surgery or having lung resection?

    PubMed

    Wang, Shaohua; Huang, Dayu; Ma, Qinyun; Chen, Xiaofeng

    2014-06-01

    A best evidence topic in perioperative care was written according to a structured protocol. The question addressed was 'Does ambroxol confer a protective effect on the lung in patients undergoing cardiac surgery or having lung resection?' A total of 247 papers were found using the reported search, of which 7 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers were tabulated. Several studies indicate that for patients with chronic obstructive pulmonary disease (COPD) who undergo cardiac surgery or upper abdominal surgery, perioperative ambroxol administration is associated with improved pulmonary function and reduced postoperative pulmonary complications (PPCs). In patients with pulmonary lobectomy, large-dose ambroxol treatment (1000 mg/day for 3 days) is correlated with reduced PPCs (6 vs 19%, P = 0.02), decreased postoperative hospital stay (5.6 vs 8.1 days, P = 0.02) and lower postoperative cost (2499 vs 5254 €, P = 0.04) compared with low-dose ambroxol treatment. Ambroxol also has a protective effect on the lungs during extracorporeal bypass, ameliorating inflammatory reaction and oxygen stress and preserving pulmonary surfactant. However, there is no evidence for any advantage of reducing PPCs after extracorporeal circulation. We conclude that perioperative application of ambroxol, a versatile mucoactive drug, particularly in high doses, is associated with lower PPCs, especially in high-risk patients with fundamental lung disease such as COPD. Large doses of ambroxol are correlated with even lower PPCs after lung resection. We recommend that routine intravenous ambroxol should be used in large doses in high-risk patients in the perioperative period to reduce the risk of PPCs. PMID:24623642

  3. STS-32 crewmembers pose with LDEF model at T-30 press conference

    NASA Technical Reports Server (NTRS)

    1989-01-01

    STS-32 crewmembers pose with a model of the Long Duration Exposure Facility (LDEF) at T-30 preflight press conference in the JSC Auditorium and Public Affairs Facility Bldg 2. From right to left are Mission Specialist (MS) G. David Low, MS Marsha S. Ivins, MS Bonnie J. Dunbar, Pilot James D. Wetherbee, and Commander Daniel C. Brandenstein standing behind a LDEF scale model and in front of a mural of a space shuttle launch.

  4. Assessment and Evaluation Modeling. Symposium 38. [AHRD Conference, 2001].

    ERIC Educational Resources Information Center

    2001

    This symposium on assessment and evaluation modeling consists of three presentations. "Training Assessment Among Kenyan Smallholder Entrepreneurs" (George G. Shibanda, Jemymah Ingado, Bernard Nassiuma) reports a study that assessed the extent to which the need for knowledge, information, and skills among small scale farmers can promote effective…

  5. Global Analysis, Interpretation, and Modelling: First Science Conference

    NASA Technical Reports Server (NTRS)

    Sahagian, Dork

    1995-01-01

    Topics considered include: Biomass of termites and their emissions of methane and carbon dioxide - A global database; Carbon isotope discrimination during photosynthesis and the isotope ratio of respired CO2 in boreal forest ecosystems; Estimation of methane emission from rice paddies in mainland China; Climate and nitrogen controls on the geography and timescales of terrestrial biogeochemical cycling; Potential role of vegetation feedback in the climate sensitivity of high-latitude regions - A case study at 6000 years B.P.; Interannual variation of carbon exchange fluxes in terrestrial ecosystems; and Variations in modeled atmospheric transport of carbon dioxide and the consequences for CO2 inversions.

  6. Summary Impacts of Modeled Provisions of the 2003 Conference Energy Bill

    EIA Publications

    2004-01-01

    This service report was undertaken at the February 2, 2004, request of Senator John Sununu to perform an assessment of the Conference Energy Bill of 2003. This report summarizes the CEB provisions that can be analyzed using the National Energy Modeling System (NEMS) and have the potential to affect energy consumption, supply, and prices. The impacts are estimated by comparing the projections with the CEB provisions to the AEO2004 Reference Case.

  7. Second International Conference on a classification of ectodermal dysplasias: development of a multiaxis model.

    PubMed

    Salinas, Carlos F; Irvine, Alan D; Itin, Peter H; Di Giovanna, John J; Schneider, Holm; Clarke, Angus J; McGovern, Laura Sternesky; Fete, Mary

    2014-10-01

    Ectodermal dysplasias (EDs) comprise a large clinically and etiologically heterogeneous group of genetic disorders characterized by abnormalities in tissues derived from the embryonic ectoderm. Controversy exists over which syndromes should be classified as EDs and which should be excluded from the classification. The challenge will be to balance comprehensiveness within the classification with usability and accessibility so that the benefits truly serve the needs of researchers, health-care providers, and ultimately the individuals and families directly affected by EDs. The overarching goal of the Second International Conference was to develop a consensus on EDs classifications, with the ultimate goal of creating a system that integrates clinical and molecular knowledge, using an interactive Internet-based database that clinicians, researchers, and laymen can use. The Conference, brought together a group of experts from around the world, including a diverse health-care providers, researchers, patient advocate representatives, and administrators. The Conference was modeled after the 2008 conference, with plenary sessions, scientific updates, and small group discussions. Based on the present clinical knowledge, new molecular advances and both coupled with new bioinformatics developments, the participants agree to develop a multi-axis system approach for the classification of EDs. The multi-axis approach will include a clinical/phenotype axis, a gene-based axis, and a functional/pathways axis. The significance of the conference outcomes includes, a new classification approach that will foster a better understanding of EDs, open new fields of research and develop a nosologic approach that may have broad implications for classifying other hereditary conditions.

  8. High-Dose Aspirin Is Associated with Anemia and Does Not Confer Benefit to Disease Outcomes in Kawasaki Disease

    PubMed Central

    Hsieh, Kai-Sheng; Guo, Mindy Ming-Huey; Huang, Ying-Hsien

    2015-01-01

    .012). Furthermore, there was also a higher serum level of hepcidin and a delayed decrease in hepcidin level after receiving IVIG in group 1 (p = 0.04 and 0.02, respectively). Conclusions These results provide evidence demonstrating that high-dose aspirin in the acute phase of KD does not confer any benefit with regards to inflammation and it does not appear to improve treatment outcomes. Therefore, high-dose aspirin is unnecessary in acute phase KD. PMID:26658843

  9. Proceedings of the Second All-USGS Modeling Conference, February 11-14, 2008: Painting the Big Picture

    USGS Publications Warehouse

    Brady, Shailaja R.

    2009-01-01

    The Second USGS Modeling Conference was held February 11-14, 2008, in Orange Beach, Ala. Participants at the conference came from all U.S. Geological Survey (USGS) regions and represented all four science discipline - Biology, Geography, Geology, and Water. Representatives from other Department of the Interior (DOI) agencies and partners from the academic community also participated. The conference, which was focused on 'painting the big picture', emphasized the following themes: Integrated Landscape Monitoring, Global Climate Change, Ecosystem Modeling, and Hazards and Risks. The conference centered on providing a forum for modelers to meet, exchange information on current approaches, identify specific opportunities to share existing models and develop more linked and integrated models to address complex science questions, and increase collaboration across disciplines and with other organizations. Abstracts for the 31 oral presentations and more than 60 posters presented at the conference are included here. The conference also featured a field trip to review scientific modeling issues along the Gulf of Mexico. The field trip included visits to Mississippi Sandhill Crane National Wildlife Refuge, Grand Bay National Estuarine Research Reserve, the 5 Rivers Delta Resource Center, and Bon Secour National Wildlife Refuge. On behalf of all the participants of the Second All-USGS Modeling Conference, the conference organizing committee expresses our sincere appreciation for the support of field trip oganizers and leaders, including the managers from the various Reserves and Refuges. The organizing committee for the conference included Jenifer Bracewell, Sally Brady, Jacoby Carter, Thomas Casadevall, Linda Gundersen, Tom Gunther, Heather Henkel, Lauren Hay, Pat Jellison, K. Bruce Jones, Kenneth Odom, and Mark Wildhaber.

  10. PREFACE: 1st International Conference on Rheology and Modeling of Materials

    NASA Astrophysics Data System (ADS)

    Gömze, László A.

    2015-04-01

    Understanding the rheological properties of materials and their rheological behaviors during their manufacturing processes and in their applications in many cases can help to increase the efficiency and competitiveness not only of the finished goods and products but the organizations and societies also. The more scientific supported and prepared organizations develop more competitive products with better thermal, mechanical, physical, chemical and biological properties and the leading companies apply more competitive knowledge, materials, equipment and technology processes. The idea to organize in Hungary the 1st International Conference on Rheology and Modeling of Materials we have received from prospective scientists, physicists, chemists, mathematicians and engineers from Asia, Europe, North and South America including India, Korea, Russia, Turkey, Estonia, France, Italy, United Kingdom, Chile, Mexico and USA. The goals of ic-rmm1 the 1st International Conference on Rheology and Modeling of Materials are the following: • Promote new methods and results of scientific research in the fields of modeling and measurements of rheological properties and behavior of materials under processing and applications. • Change information between the theoretical and applied sciences as well as technical and technological implantations. • Promote the communication between the scientists of different disciplines, nations, countries and continents. The international conference ic-rmm1 provides a platform among the leading international scientists, researchers, PhD students and engineers for discussing recent achievements in measurement, modeling and application of rheology in materials technology and materials science of liquids, melts, solids, crystals and amorphous structures. Among the major fields of interest are the influences of material structures, mechanical stresses temperature and deformation speeds on rheological and physical properties, phase transformation of

  11. 4. International reservoir characterization technical conference

    SciTech Connect

    1997-04-01

    This volume contains the Proceedings of the Fourth International Reservoir Characterization Technical Conference held March 2-4, 1997 in Houston, Texas. The theme for the conference was Advances in Reservoir Characterization for Effective Reservoir Management. On March 2, 1997, the DOE Class Workshop kicked off with tutorials by Dr. Steve Begg (BP Exploration) and Dr. Ganesh Thakur (Chevron). Tutorial presentations are not included in these Proceedings but may be available from the authors. The conference consisted of the following topics: data acquisition; reservoir modeling; scaling reservoir properties; and managing uncertainty. Selected papers have been processed separately for inclusion in the Energy Science and Technology database.

  12. PREFACE: IC-MSQUARE 2012: International Conference on Mathematical Modelling in Physical Sciences

    NASA Astrophysics Data System (ADS)

    Kosmas, Theocharis; Vagenas, Elias; Vlachos, Dimitrios

    2013-02-01

    The first International Conference on Mathematical Modelling in Physical Sciences (IC-MSQUARE) took place in Budapest, Hungary, from Monday 3 to Friday 7 September 2012. The conference was attended by more than 130 participants, and hosted about 290 oral, poster and virtual papers by more than 460 pre-registered authors. The first IC-MSQUARE consisted of different and diverging workshops and thus covered various research fields in which mathematical modelling is used, such as theoretical/mathematical physics, neutrino physics, non-integrable systems, dynamical systems, computational nanoscience, biological physics, computational biomechanics, complex networks, stochastic modelling, fractional statistics, DNA dynamics, and macroeconomics. The scientific program was rather heavy since after the Keynote and Invited Talks in the morning, two parallel sessions ran every day. However, according to all attendees, the program was excellent with a high level of talks and the scientific environment was fruitful; thus all attendees had a creative time. The mounting question is whether this occurred accidentally, or whether IC-MSQUARE is a necessity in the field of physical and mathematical modelling. For all of us working in the field, the existing and established conferences in this particular field suffer from two distinguished and recognized drawbacks: the first is the increasing orientation, while the second refers to the extreme specialization of the meetings. Therefore, a conference which aims to promote the knowledge and development of high-quality research in mathematical fields concerned with applications of other scientific fields as well as modern technological trends in physics, chemistry, biology, medicine, economics, sociology, environmental sciences etc., appears to be a necessity. This is the key role that IC-MSQUARE will play. We would like to thank the Keynote Speaker and the Invited Speakers for their significant contributions to IC-MSQUARE. We would also

  13. Funding to Support the Participation of Scientists Engaged in DOE Research in the 2008 AGU Chapman Conference on Biogeophysics. Final Report

    SciTech Connect

    Slater, Lee D.

    2009-05-11

    This project provided travel awards for scientists engaged in research relevant to the DOE mission to participate in the American Geophysical Union (AGU) Chapman Conference on Biogeophysics held October 13-16, 2008, in Portland, Maine (http://www.agu.org/meetings/chapman/2008/fcall/). The objective of this Chapman Conference was to bring together geophysicists, biophysicists, geochemists, geomicrobiologists, and environmental microbiologists that are leaders in their field and have a personal interest in exploring this new interdisciplinary field or are conducting multidisciplinary research with potential impact on biogeophysics in order to define the current state of the science, identify the critical questions facing the community and to generate a roadmap for establishing biogeophysics as a critical subdiscipline of earth science research. The sixty participants were an international group of academics, graduate students and scientists at government laboratories engaged in biogeophysics related research. Scientists from Europe, Israel and China traveled to engage North American colleagues in this highly focused 3.5 day meeting. The group included an approximately equal mix of microbiologists, biogeochemists and near surface geophysicists. The recipients of the DOE travel awards were [1] Dennis Bazylinski (University of Nevada, Las Vegas), [2] Yuri Gorby (Craig Venter Institute), [3] Carlos Santamarina (Georgia Tech), [4] Susan Hubbard (Lawrence Berkeley Laboratory), [5] Roelof Versteeg (Idaho National Laboratory), [6] Eric Roden (University of Wisconsin), [7] George Luther (University of Delaware), and [8] Jinsong Chen (Lawrence Berkeley Laboratory)

  14. EDITORIAL: International Conference on Finite Fermionic Systems: Nilsson Model 50 Years

    NASA Astrophysics Data System (ADS)

    2006-06-01

    In 1955 Sven Gösta Nilsson published the paper `Binding States of Individual Nucleons in Strongly Deformed Nuclei'. This eminent work has been crucial for the understanding of the structure of deformed atomic nuclei. Moreover, the so-called Nilsson model has been widely used for the description of other types of finite systems of fermions such as quantum dots and cold fermionic atoms. During one week in June 2005 we celebrated in Lund the 50th anniversary of the Nilsson model with the International Conference on Finite Fermionic Systems - Nilsson Model 50 Years. With the historical view in mind, the conference focused on present and future problems in nuclear structure physics as well as on the physics of other types of finite Fermi systems. As a background to the recent developments Nobel Laureate Ben Mottelson presented a recollection of early applications and achievements of the Nilsson model in the first talk of the conference, including a personal view of Sven Gösta Nilsson. We are particularly pleased that this contribution could be included in these proceedings. The scientific programme was structured according to the following subjects: Shell structure and deformations The heaviest elements and beyond Nuclei far from stability Pairing correlations Nuclear spectroscopy: large deformations Nuclear spectroscopy: rotational states Order and chaos Cold fermionic atoms Quantum dots Many new and interesting results were presented in the 15 invited talks, 30 oral contributions, and in the 33 papers of the poster sessions. The present volume of Physica Scripta contains most of the talks, as well as the short contributions of the posters. We thank the speakers and all participants who actively contributed to give this memorable conference a very high scientific level in the presented contributions, as well as in numerous discussions inside and outside the sessions. We also thank the international advisory committee for their invaluable work in helping us setting up

  15. PREFACE: 4th International Conference on Mathematical Modeling in Physical Sciences (IC-MSquare2015)

    NASA Astrophysics Data System (ADS)

    Vlachos, Dimitrios; Vagenas, Elias C.

    2015-09-01

    The 4th International Conference on Mathematical Modeling in Physical Sciences (IC-MSQUARE) took place in Mykonos, Greece, from Friday 5th June to Monday 8th June 2015. The Conference was attended by more than 150 participants and hosted about 200 oral, poster, and virtual presentations. There were more than 600 pre-registered authors. The 4th IC-MSQUARE consisted of different and diverging workshops and thus covered various research fields where Mathematical Modeling is used, such as Theoretical/Mathematical Physics, Neutrino Physics, Non-Integrable Systems, Dynamical Systems, Computational Nanoscience, Biological Physics, Computational Biomechanics, Complex Networks, Stochastic Modeling, Fractional Statistics, DNA Dynamics, Macroeconomics etc. The scientific program was rather intense as after the Keynote and Invited Talks in the morning, three parallel oral and one poster session were running every day. However, according to all attendees, the program was excellent with a high quality of talks creating an innovative and productive scientific environment for all attendees. We would like to thank the Keynote Speaker and the Invited Speakers for their significant contribution to IC-MSQUARE. We also would like to thank the Members of the International Advisory and Scientific Committees as well as the Members of the Organizing Committee.

  16. PREFACE: 3rd International Conference on Mathematical Modeling in Physical Sciences (IC-MSQUARE 2014)

    NASA Astrophysics Data System (ADS)

    2015-01-01

    The third International Conference on Mathematical Modeling in Physical Sciences (IC-MSQUARE) took place at Madrid, Spain, from Thursday 28 to Sunday 31 August 2014. The Conference was attended by more than 200 participants and hosted about 350 oral, poster, and virtual presentations. More than 600 pre-registered authors were also counted. The third IC-MSQUARE consisted of different and diverging workshops and thus covered various research fields where Mathematical Modeling is used, such as Theoretical/Mathematical Physics, Neutrino Physics, Non-Integrable Systems, Dynamical Systems, Computational Nanoscience, Biological Physics, Computational Biomechanics, Complex Networks, Stochastic Modeling, Fractional Statistics, DNA Dynamics, Macroeconomics etc. The scientific program was rather heavy since after the Keynote and Invited Talks in the morning, three parallel oral sessions and one poster session were running every day. However, according to all attendees, the program was excellent with high level of talks and the scientific environment was fruitful, thus all attendees had a creative time. We would like to thank the Keynote Speaker and the Invited Speakers for their significant contribution to IC-MSQUARE. We also would like to thank the Members of the International Advisory and Scientific Committees as well as the Members of the Organizing Committee.

  17. PREFACE: 2nd International Conference on Mathematical Modeling in Physical Sciences 2013 (IC-MSQUARE 2013)

    NASA Astrophysics Data System (ADS)

    2014-03-01

    The second International Conference on Mathematical Modeling in Physical Sciences (IC-MSQUARE) took place at Prague, Czech Republic, from Sunday 1 September to Thursday 5 September 2013. The Conference was attended by more than 280 participants and hosted about 400 oral, poster, and virtual presentations while counted more than 600 pre-registered authors. The second IC-MSQUARE consisted of different and diverging workshops and thus covered various research fields where Mathematical Modeling is used, such as Theoretical/Mathematical Physics, Neutrino Physics, Non-Integrable Systems, Dynamical Systems, Computational Nanoscience, Biological Physics, Computational Biomechanics, Complex Networks, Stochastic Modeling, Fractional Statistics, DNA Dynamics, Macroeconomics. The scientific program was rather heavy since after the Keynote and Invited Talks in the morning, three parallel sessions were running every day. However, according to all attendees, the program was excellent with high level of talks and the scientific environment was fruitful, thus all attendees had a creative time. We would like to thank the Keynote Speaker and the Invited Speakers for their significant contribution to IC-MSQUARE. We also would like to thank the Members of the International Advisory and Scientific Committees as well as the Members of the Organizing Committee. Further information on the editors, speakers and committees is available in the attached pdf.

  18. PREFACE: MCWASP XIII: International Conference on Modeling of Casting, Welding and Advanced Solidification Processes

    NASA Astrophysics Data System (ADS)

    Ludwig, Andreas

    2012-07-01

    Due to fast-paced development in computer technologies during the last three decades, computer-based process modeling has become an important tool for the improvement of existing process technologies and the development of new, innovative technologies. With the help of numerical process simulations, complex and costly experimental trials can now be reduced to a minimum. For metallurgical processes in particular, computer simulations are of outstanding importance, as the flow and solidification of molten alloys or the formation of microstructure and defects can hardly be observed experimentally. Corresponding computer simulations allow us inside views into the key process phenomena and so offer great potential for optimization. In 1980 the conference series 'Modeling of Casting, Welding and Advanced Solidification Processes (MCWASP)' was started up, and has now been continued by holding the 13th international conference on 'Modeling of Casting, Welding and Advanced Solidification Processes', MCWASP XIII, in Schladming, Austria, from June 17-22 2012. Around 200 scientists from industry and academia, coming from 20 countries around the globe attended 78 oral and 50 poster presentations on different aspects of solidification-related modeling topics. Besides process-related sessions such as (i) Ingot and Shape Casting, (ii) Continuous Casting and Direct Chill Casting, (iii) Directional Solidification and Zone Melting, (iv) Welding, and (v) Centrifugal Casting, a larger focus was put on (vi) Experimental Investigation and In-Situ Observations. In recent years, this topic has been significantly strengthened as advanced synchrotron technologies allow fantastic in-situ observations of phenomena happening inside small metallic samples. These observations will definitely serve as a benchmark for the modeling community. Further macroscopic aspects of advanced solidification science were tackled in the sessions (vii) Electromagnetic Coupling, (viii) Thermomechanics, (ix

  19. A practical hybrid model of application, integration, and competencies at interactive table conferences in histology (ITCH).

    PubMed

    Ettarh, Rajunor

    2016-05-01

    Significant changes have been implemented in the way undergraduate medical education is structured. One of the challenges for component courses such as histology in medical and dental curricula is to restructure and deliver training within new frameworks. This article describes the process of aligning the purpose and experience in histology laboratory to the goal of applying knowledge gained to team-based medical practice at Tulane University School of Medicine. Between 2011 and 2015, 711 medical students took either a traditional laboratory-based histology course (353 students) or a team-based hybrid histology course with active learning in laboratory (358 students). The key difference was in the laboratory component of the hybrid course - interactive table conferences in histology-during which students developed new competencies by working in teams, reviewing images, solving problems by applying histology concepts, and sharing learning. Content, faculty and online resources for microscopy were the same in both courses. More student-student and student-faculty interactions were evident during the hybrid course but student evaluation ratings and grades showed reductions following introduction of table conferences when compared to previous ratings. However, outcomes at National Board of Medical Examiners(®) (NBME(®) ) Subject Examination in Histology and Cell Biology showed significant improvement (72.4 ± 9.04 and 76.44 ± 9.36 for percent correct answers, traditional and hybrid courses, respectively, P < 0.0001). This model of table conferences to augment the traditional histology laboratory experience exemplifies the extent that restructuring enhancements can be used in currently taught courses in the undergraduate medical curriculum. Anat Sci Educ 9: 286-294. © 2016 American Association of Anatomists.

  20. A practical hybrid model of application, integration, and competencies at interactive table conferences in histology (ITCH).

    PubMed

    Ettarh, Rajunor

    2016-05-01

    Significant changes have been implemented in the way undergraduate medical education is structured. One of the challenges for component courses such as histology in medical and dental curricula is to restructure and deliver training within new frameworks. This article describes the process of aligning the purpose and experience in histology laboratory to the goal of applying knowledge gained to team-based medical practice at Tulane University School of Medicine. Between 2011 and 2015, 711 medical students took either a traditional laboratory-based histology course (353 students) or a team-based hybrid histology course with active learning in laboratory (358 students). The key difference was in the laboratory component of the hybrid course - interactive table conferences in histology-during which students developed new competencies by working in teams, reviewing images, solving problems by applying histology concepts, and sharing learning. Content, faculty and online resources for microscopy were the same in both courses. More student-student and student-faculty interactions were evident during the hybrid course but student evaluation ratings and grades showed reductions following introduction of table conferences when compared to previous ratings. However, outcomes at National Board of Medical Examiners(®) (NBME(®) ) Subject Examination in Histology and Cell Biology showed significant improvement (72.4 ± 9.04 and 76.44 ± 9.36 for percent correct answers, traditional and hybrid courses, respectively, P < 0.0001). This model of table conferences to augment the traditional histology laboratory experience exemplifies the extent that restructuring enhancements can be used in currently taught courses in the undergraduate medical curriculum. Anat Sci Educ 9: 286-294. © 2016 American Association of Anatomists. PMID:26749245

  1. [Consensus conferences in Israel--a collaborative model for national policy making].

    PubMed

    Tal, Orna; Oberlander, Shira; Siebzehner, Miri I

    2014-07-01

    The determination of an integrated national policy on controversial issues is a challenge for health systems worldwide. A common method to reach agreements for national policies in different countries throughout the world is group discussion that involves all stakeholders. A structured model of discussion on medical technologies started in the 1970s, mostly in North America, spreading to Europe and in the last decade also crossed borders to India, South America and Israel. Public discussion in the format of a consensus conference is a complex process that includes a thorough literature review for technology assessment, combining academic information using a technique of close consultation with experts, extensive panel discussion and dialogue with representatives of the public. At the end of the process a broad consensus is determined facilitating national-level policy implementation. The multiple factors involved, the issues addressed, the nature of the health system where the intended results will be applied, as well as political and social characteristics, produce variations among different countries. Therefore, this process requires flexibility in adjusting the classic model according to the awakening needs. The advantages of this method include encouraging the appropriate utilization of existing technologies, contemporary assessment by leading experts, aligning between all involved parties, public sharing and more. The initial model of the consensus conference was implemented in an orderly, systematic, structured process which allowed broad discussion, and many factors for thorough preparation. The disadvantages are its complexity, length and cost. In order to cope with the dynamics of the health system in israel, forcing policymakers to make decisions in real time, parts of the model were adjusted to address the issues arising in the system. Hence, a new process was developed--a derivative of the original Israeli model, with an emphasis on professional reviews

  2. 25 CFR 1000.424 - Does a Tribe/Consortium have a right to an informal conference to resolve any disputes?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... a right to an informal conference to resolve any disputes? Yes, the Tribe/Consortium may request an informal conference (a non-binding alternative dispute resolution process). An informal conference is a way... conference to resolve any disputes? 1000.424 Section 1000.424 Indians OFFICE OF THE ASSISTANT...

  3. 25 CFR 1000.424 - Does a Tribe/Consortium have a right to an informal conference to resolve any disputes?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... a right to an informal conference to resolve any disputes? Yes, the Tribe/Consortium may request an informal conference (a non-binding alternative dispute resolution process). An informal conference is a way... conference to resolve any disputes? 1000.424 Section 1000.424 Indians OFFICE OF THE ASSISTANT...

  4. Geometric models, antenna gains, and protection ratios as developed for BC SAT-R2 conference software

    NASA Technical Reports Server (NTRS)

    Miller, E. F.

    1982-01-01

    Mathematical models used in the software package developed for use at the 1983 Regional Administrative Radio Conference on broadcasting satellites. The models described are those used in the Spectrum Orbit Utilization Program (SOUP) analysis. The geometric relationships necessary to model broadcasting satellite systems are discussed. Antenna models represent copolarized and cross polarized performance as functions of the off axis angle. The protection ratio is modelled as a co-channel value and a template representing systems with frequency offsets.

  5. Energy Conferences and Symposia; (USA)

    SciTech Connect

    Osborne, J.H.; Simpson, W.F. Jr.

    1991-01-01

    Energy Conferences and Symposia, a monthly publication, was instituted to keep scientists, engineers, managers, and related energy professionals abreast of meetings sponsored by the Department of Energy (DOE) and by other technical associations. Announcements cover conference, symposia, workshops, congresses, and other formal meetings pertaining to DOE programmatic interests. Complete meeting information, including title, sponsor, and contact, is presented in the main section, which is arranged alphabetically by subject area. Within a subject, citations are sorted by beginning data of the meeting. New listings are indicated by a bullet after the conference number and DOE-sponsored conferences are indicated by a star. Two indexes are provided for cross referencing conference information. The Chronological Index lists conference titles by dates and gives the subject area where complete information they may be found. The Location Index is alphabetically sorted by the city where the conference will be held.

  6. Estuarine modeling: Does a higher grid resolution improve model performance?

    EPA Science Inventory

    Ecological models are useful tools to explore cause effect relationships, test hypothesis and perform management scenarios. A mathematical model, the Gulf of Mexico Dissolved Oxygen Model (GoMDOM), has been developed and applied to the Louisiana continental shelf of the northern ...

  7. Proceedings of the tenth annual DOE low-level waste management conference: Session 4: Waste treatment minimization

    SciTech Connect

    Not Available

    1988-12-01

    This document contains eleven papers on various aspects of low-level radioactive waste management. Topics in this volume include: volume reduction plans; incentitives; and cost proposals; acid detoxification and reclamation; decontamination of lead; leach tests; West Valley demonstration project status report; and DOE's regional management strategies. Individual papers were processed separately for the data base. (TEM)

  8. Novel K540N mutation in Plasmodium falciparum dihydropteroate synthetase confers a lower level of sulfa drug resistance than does a K540E mutation.

    PubMed

    Lumb, Vanshika; Sharma, Yagya D

    2011-05-01

    Sulfadoxine (SDX) and sulfamethoxazole (SMX) each inhibit the Plasmodium falciparum dihydropteroate synthetase (PfDHPS), and certain point mutations in this enzyme yield the drug-resistant parasite. Using a simple Escherichia coli model system, we describe here the effect of the recently reported novel K540N mutation in PfDHPS on the level of SDX/SMX resistance. The survival rate of the transformed E. coli (DHPS-deficient strain) under different SDX or SMX concentrations revealed that the K540N mutation confers a lower level of drug resistance than its contemporary K540E mutation. Further, SMX was more effective than SDX in the E. coli system.

  9. Does Older Age Confer an Increased Risk of Incident Neurocognitive Disorders Among Persons Living with HIV Disease?

    PubMed Central

    Sheppard, David P.; Woods, Steven Paul; Bondi, Mark W.; Gilbert, Paul E.; Massman, Paul J.; Doyle, Katie L.

    2015-01-01

    Objective This study aimed to determine the combined effects of age and HIV infection on the risk of incident neurocognitive disorders. Method A total of 146 neurocognitively normal participants were enrolled at baseline into one of four groups based on age (≤ 40 years and ≥ 50 years) and HIV serostatus resulting in 24 younger HIV−, 27 younger HIV+, 39 older HIV−, and 56 older HIV+ individuals. All participants were administered a standardized clinical neuropsychological battery at baseline and 14.3 ±0.2 months later. Results A logistic regression predicting incident neurocognitive disorders from HIV, age group, and their interaction was significant (χ2[4] = 13.56, p = .009), with a significant main effect of HIV serostatus (χ2[1] = 5.01, p = .025), but no main effect of age or age by HIV interaction (ps > .10). Specifically, 15.7 percent of the HIV+ individuals had an incident neurocognitive disorder as compared to 3.2 percent of the HIV− group (odds ratio = 4.8 [1.2, 32.6]). Among older HIV+ adults, lower baseline cognitive reserve, prospective memory, and verbal fluency each predicted incident neurocognitive disorders at follow-up. Conclusions Independent of age, HIV infection confers a nearly 5-fold risk for developing a neurocognitive disorder over approximately one year. Individuals with lower cognitive reserve and mild weaknesses in higher-order neurocognitive functions may be targeted for closer clinical monitoring and preventative measures. PMID:26367342

  10. 10 CFR 205.171 - Conferences.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Conferences. 205.171 Section 205.171 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Conferences, Hearings, and Public Hearings § 205.171 Conferences. (a) The DOE in its discretion may direct that a conference be convened, on its own initiative...

  11. Is less really more: Does a prefrontal efficiency genotype actually confer better performance when working memory becomes difficult?

    PubMed

    Ihne, Jessica L; Gallagher, Natalie M; Sullivan, Marie; Callicott, Joseph H; Green, Adam E

    2016-01-01

    Perhaps the most widely studied effect to emerge from the combination of neuroimaging and human genetics is the association of the COMT-Val(108/158)Met polymorphism with prefrontal activity during working memory. COMT-Val is a putative risk factor in schizophrenia, which is characterized by disordered prefrontal function. Work in healthy populations has sought to characterize mechanisms by which the valine (Val) allele may lead to disadvantaged prefrontal cognition. Lower activity in methionine (Met) carriers has been interpreted as advantageous neural efficiency. Notably, however, studies reporting COMT effects on neural efficiency have generally not reported working memory performance effects. Those studies have employed relatively low/easy working memory loads. Higher loads are known to elicit individual differences in working memory performance that are not visible at lower loads. If COMT-Met confers greater neural efficiency when working memory is easy, a reasonable prediction is that Met carriers will be better able to cope with increasing demand for neural resources when working memory becomes difficult. To our knowledge, this prediction has thus far gone untested. Here, we tested performance on three working memory tasks. Performance on each task was measured at multiple levels of load/difficulty, including loads more demanding than those used in prior studies. We found no genotype-by-load interactions or main effects of COMT genotype on accuracy or reaction time. Indeed, even testing for performance differences at each load of each task failed to find a single significant effect of COMT genotype. Thus, even if COMT genotype has the effects on prefrontal efficiency that prior work has suggested, such effects may not directly impact high-load working memory ability. The present findings accord with previous evidence that behavioral effects of COMT are small or nonexistent and, more broadly, with a growing consensus that substantial effects on phenotype will

  12. Does high diurnal variability in a reef flat from Ofu, American Samoa confer resistance to ocean acidification?

    NASA Astrophysics Data System (ADS)

    Koweek, D.; Samuel, L.; Mucciarone, D. A.; Woodson, C. B.; Monismith, S. G.; Dunbar, R. B.

    2012-12-01

    Forecasts for coral reefs under various ocean acidification scenarios are becoming increasingly complex due to significant inter-site variability in biogeochemistry, ecology, and physical oceanography. The reef flats of Ofu, American Samoa are a potential end-member of this vulnerability spectrum due to extremely high diurnal variability in their biogeochemistry. Here we present coupled biogeochemical and physical oceanographic measurements from a shallow reef flat on Ofu in November 2011. We observed diurnal temperature ranges of up to 7°C, along with diurnal pH and dissolved oxygen ranges of 0.6 units, and 160 percent of saturation, respectively. Carbon system measurements were less extreme. Alkalinity varied between 2240-2360 μmol/kg and total dissolved inorganic carbon (TDIC) ranged between 1850-2100 μmol/kg during the diurnal cycle. These observations suggest diurnal ranges of ~240ppm CO2 and 1.5 units of ΩAr. The larger diurnal range in TDIC relative to alkalinity suggests a reef environment dominated by photosynthesis. From these observations, we explore the balance between the dominant biogeochemical processes of production and calcification on the reef flat in more detail, along with its implication for conferring resistance to ocean acidification. We use calcification rate estimates to provide insight to patterns of day and night growth and/or dissolution on the reef. Finally, we present evidence of tidal modulation of the biogeochemical signals and discuss the role of localized physical circulation in helping to determine a reef's vulnerability to ocean acidification.

  13. Induction of a Major Leaf Acid Phosphatase Does Not Confer Adaptation to Low Phosphorus Availability in Common Bean1

    PubMed Central

    Yan, Xiaolong; Liao, Hong; Trull, Melanie C.; Beebe, Steve E.; Lynch, Jonathan P.

    2001-01-01

    Acid phosphatase is believed to be important for phosphorus scavenging and remobilization in plants, but its role in plant adaptation to low phosphorus availability has not been critically evaluated. To address this issue, we compared acid phosphatase activity (APA) in leaves of common bean (Phaseolus vulgaris) in a phosphorus-inefficient genotype (DOR364), a phosphorus-efficient genotype (G19833), and their F5.10 recombinant inbred lines (RILs). Phosphorus deficiency substantially increased leaf APA, but APA was much higher and more responsive to phosphorus availability in DOR364 than in G19833. Leaf APA segregated in the RILs, with two discrete groups having either high (mean = 1.71 μmol/mg protein/min) or low (0.36 μmol/mg protein/min) activity. A chi-square test indicated that the observed difference might be controlled by a single gene. Non-denaturing protein electrophoresis revealed that there are four visible isoforms responsible for total APA in common bean, and that the difference in APA between contrasting genotypes could be attributed to the existence of a single major isoform. Qualitative mapping of the APA trait and quantitative trait loci analysis with molecular markers indicated that a major gene contributing to APA is located on linkage group B03 of the unified common bean map. This locus was not associated with loci conferring phosphorus acquisition efficiency or phosphorus use efficiency. RILs contrasting for APA had similar phosphorus pools in old and young leaves under phosphorus stress, arguing against a role for APA in phosphorus remobilization. Our results do not support a major role for leaf APA induction in regulating plant adaptation to phosphorus deficiency. PMID:11299369

  14. 10 CFR 820.22 - Informal conference.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Informal conference. 820.22 Section 820.22 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES Enforcement Process § 820.22 Informal conference. The Director may convene an informal conference to discuss any situation that might be a violation of the Act or a DOE Nuclear...

  15. Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson's disease.

    PubMed

    Qin, Jiaojiao; Wu, Meilong; Yu, Shu; Gao, Xiaorong; Zhang, Jingjing; Dong, Xingyue; Ji, Jinyan; Zhang, Yuxi; Zhou, Lin; Zhang, Qi; Ding, Fei

    2015-11-01

    Pyrroloquinoline quinone (PQQ), a redox cofactor in the mitochondrial respiratory chain, has proven to protect neurons against glutamate-induced damage both in vitro and in vivo. This study was aimed to investigate the possible neuroprotective effects of PQQ in rotenone-induced Parkinson's disease (PD) model. Pre-treatment with PQQ prevented cultured SH-SY5Y cells from rotenone-induced apoptosis, accompanied by modulation of apoptosis-related proteins (Bcl-2, Bax and Smac), restoration of the mitochondrial membrane potential, inhibition of intracellular reactive oxygen species (ROS) production, suppression of tyrosine residues nitration, and dopamine redistribution. PQQ also exerted protective effects in an in vivo PD model, which was created by rotenone injection into the medial forebrain bundle of rats. Co-injection with PQQ and rotenone improved the apomorphine-evoked rotation, decreased neuronal loss, increased the ROS-scavenging ability, regulated intracellular expressions of mitochondrial complex subunits (Ndufs1-4), tyrosine hydroxylase, and vesicular monoamine transporter 2. Taken together, our results collectively suggest that PQQ confers neuroprotection in rotenone-induced PD model probably through complex and multifaceted mechanisms, at least involving oxidative stress, mitochondrial integrity, and dopamine functions.

  16. Second biennial tri-laboratory engineering conference on modeling and simulation

    SciTech Connect

    1997-12-31

    This conference was divided into eight sessions. Session one covered the following topics: material behavior and characterization; computation heat transfer; computational fluid dynamics; and hydrodynamics. Topics covered in session two were: structural dynamics; manufacturing process modeling; solid and structural mechanics; and electromagnetics. Session three topics were: materials behavior and characterization; computational heat transfer; computational fluid dynamics; neutron generators and gas transfer systems applications. Topics for session four were: mesh generation and visualization; validation and verification; and pit manufacturing. Session five covered the following: ALE techniques and applications; solid and structural mechanical; and system applications. The three topics of session six were: optimization methods; manufacturing process modeling; and weapon response in hostile environments. Session covered: material behavior and characterization; computational heat transfer; solid and structural mechanics; and mesh generation and visualization. And finally, the topics of session 8 were: manufacturing and process modeling; solid and structural mechanics; uncertainty analysis; and structural dynamics. Paper covered a range of applications, many of which were weapons and weapon systems.

  17. An Innovative Marketing Model: Promoting Technical Programs by Conducting One-Day Conferences.

    ERIC Educational Resources Information Center

    Petrosian, Anahid

    This document examines an innovative marketing strategy developed by South Texas Community College (STCC) to promote its technical programs. In 2000, STCC organized the "Business Conference Institute" to develop 1-day conferences with the Division of Business, Math & Sciences (DBMS). The creation of this Institute linked the College with the local…

  18. The PBS Triangle: Does It Fit as a Heuristic? A Reflection on the First International Conference on Positive Behavior Support

    ERIC Educational Resources Information Center

    Baker, Candace Kay

    2005-01-01

    In this article, the author explores the evolution of the use of the triangle as a communication tool for describing positive behavior support (PBS) systems. The conceptual framework for the triangle used for PBS is credited to Walker et al. In that seminal work, the a model of school-based prevention strategies for children displaying antisocial…

  19. Proceedings of the tenth annual DOE low-level waste management conference: Session 2: Site performance assessment

    SciTech Connect

    Not Available

    1988-12-01

    This document contains twelve papers on various aspects of low-level radioactive waste management. Topics of this volume include: performance assessment methodology; remedial action alternatives; site selection and site characterization procedures; intruder scenarios; sensitivity analysis procedures; mathematical models for mixed waste environmental transport; and risk assessment methodology. Individual papers were processed separately for the database. (TEM)

  20. Meeting Our Users where They Conference: A Texas A&M Model to Support Librarian Attendance at Subject-Specific Conferences

    ERIC Educational Resources Information Center

    Hankins, Rebecca; Melgoza, Pauline; Seeger, Christina; Wan, Gary

    2009-01-01

    Today's academic librarian is frequently called upon to function as a subject specialist, with or without advanced degrees in other disciplines. One method of monitoring trends within a given field is to study its literature; another is to attend conferences in the discipline. Discipline-specific conference attendance by academic librarians…

  1. A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1

    PubMed Central

    Langer, Simon M.; Hopfensperger, Kristina; Iyer, Shilpa S.; Kreider, Edward F.; Learn, Gerald H.; Lee, Lan-Hui; Hahn, Beatrice H.; Sauter, Daniel

    2015-01-01

    Background Pandemic strains of HIV-1 (group M) encode a total of nine structural (gag, pol, env), regulatory (rev, tat) and accessory (vif, vpr, vpu, nef) genes. However, some subtype A and C viruses exhibit an unusual gene arrangement in which the first exon of rev (rev1) and the vpu gene are placed in the same open reading frame. Although this rev1-vpu gene fusion is present in a considerable fraction of HIV-1 strains, its functional significance is unknown. Results Examining infectious molecular clones (IMCs) of HIV-1 that encode the rev1-vpu polymorphism, we show that a fusion protein is expressed in infected cells. Due to the splicing pattern of viral mRNA, however, these same IMCs also express a regular Vpu protein, which is produced at much higher levels. To investigate the function of the fusion gene, we characterized isogenic IMC pairs differing only in their ability to express a Rev1-Vpu protein. Analysis in transfected HEK293T and infected CD4+ T cells showed that all of these viruses were equally active in known Vpu functions, such as down-modulation of CD4 or counteraction of tetherin. Furthermore, the polymorphism did not affect Vpu-mediated inhibition of NF-кB activation or Rev-dependent nuclear export of incompletely spliced viral mRNAs. There was also no evidence for enhanced replication of Rev1-Vpu expressing viruses in primary PBMCs or ex vivo infected human lymphoid tissues. Finally, the frequency of HIV-1 quasispecies members that encoded a rev1-vpu fusion gene did not change in HIV-1 infected individuals over time. Conclusions Expression of a rev1-vpu fusion gene does not affect regular Rev and Vpu functions or alter HIV-1 replication in primary target cells. Since there is no evidence for increased replication fitness of rev1-vpu encoding viruses, this polymorphism likely emerged in the context of other mutations within and/or outside the rev1-vpu intergenic region, and may have a neutral phenotype. PMID:26554585

  2. Does the option to rotate the Elekta Beam Modulator MLC during VMAT IMRT delivery confer advantage?--a study of 'parked gaps'.

    PubMed

    Webb, S

    2010-06-01

    When delivering intensity-modulated radiation therapy (IMRT) using the volumetric modulated arc therapy (VMAT) technique on an Elekta accelerator equipped with the Elekta Beam Modulator multileaf collimator (MLC), the orientation of the MLC, relative to the accelerator head, is generally fixed during the delivery. However, it has the ability to rotate about its axis as the gantry simultaneously rotates. This note shows that this can confer a potential advantage when planning and delivering IMRT via VMAT. A computer model has been built in which the MLC rotation angle could be varied with each control point (gantry location) within the constraints of the specified MLC rotation speed and the time available for rotation. The model was used to optimize the orientation trajectory in such a way as to minimize the number of parked gaps between leaves which are needed for some gantry orientations but not for others (and which cannot reach the shielding safety of surrounding jaws in the time available). The presented work started with the simple situation of collimating gantry-successive single convex shapes. As a broad statement some 40% reduction in such parked gaps could be achieved. The study was then extended to investigate the optimized trajectories for multiple separate concave shapes with, once again, a saving in unwanted parked gaps or unwanted over-irradiation.

  3. A Model Pre-Service Teacher Conference: Getting New Teachers "Hooked on Geography"

    ERIC Educational Resources Information Center

    Hutson, Martha; Rutherford, David J.; Foster, Ellen J.; Richardson, Bobbie

    2014-01-01

    This article presents one approach to providing geography education training to pre-service teachers--a two-day, professional development conference dedicated to preservice teachers and provided to them at no cost. The authors begin by explaining more fully the need for reaching pre-service teachers with good training in geography education. A…

  4. Modeling, Simulation and Analysis of Complex Networked Systems: A Program Plan for DOE Office of Advanced Scientific Computing Research

    SciTech Connect

    Brown, D L

    2009-05-01

    , and (4) design, situational awareness and control of complex networks. The program elements consist of a group of Complex Networked Systems Research Institutes (CNSRI), tightly coupled to an associated individual-investigator-based Complex Networked Systems Basic Research (CNSBR) program. The CNSRI's will be principally located at the DOE National Laboratories and are responsible for identifying research priorities, developing and maintaining a networked systems modeling and simulation software infrastructure, operating summer schools, workshops and conferences and coordinating with the CNSBR individual investigators. The CNSBR individual investigator projects will focus on specific challenges for networked systems. Relevancy of CNSBR research to DOE needs will be assured through the strong coupling provided between the CNSBR grants and the CNSRI's.

  5. Two-dimensional model of a capacitively coupled rf discharge and comparisons with experiments in the Gaseous Electronics Conference reference reactor

    NASA Astrophysics Data System (ADS)

    Boeuf, J. P.; Pitchford, L. C.

    1995-02-01

    We present results from a two-dimensional (2D) numerical fluid model of rf discharges in conditions close to recently published measurements of the spatial distribution of plasma density in the Gaseous Electronic Conference reference cell. The discharge is in pure argon at pressures in the 100 mtorr range, frequency 13.56 MHz, and rf voltage amplitudes on the order of 100 V. The model is based on solutions of the continuity, momentum (drift-diffusion), and energy equations for the electrons, continuity, and drift-diffusion equation for positive ions, coupled with the Poisson equation. The results of the model are qualitatively and quantitatively in good agreement with the experiments. The model predicts a maximum of plasma density off axis, as in the experiment. The ion current density on the electrode is also nonuniform, and increases radially in the conditions of the experiments. The effects of the rf voltage, pressure, and reactor geometry (electrode dimensions, gap length, guard rings, etc.) on the plasma properties and on the uniformity of the ion current on the powered electrode are also discussed. It is shown that the existence of a maximum of plasma density in the radial direction, in the conditions of the experiment, is due to the small value of the electrode spacing. The results show that the harmonic content of the discharge current is also geometry dependent. The comparisons show that 2D, three-moment fluid models can accurately describe the discharge and the effects of the chamber geometry on the plasma properties for pressure above the limit where collisionless electron heating does not play a significant role.

  6. Conference Resolution

    NASA Astrophysics Data System (ADS)

    2009-04-01

    Since the first IUPAP International Conference on Women in Physics (Paris, March 2002) and the Second Conference (Rio de Janeiro, May 2005), progress has continued in most countries and world regions to attract girls to physics and advance women into leadership roles, and many working groups have formed. The Third Conference (Seoul, October 2008), with 283 attendees from 57 countries, was dedicated to celebrating the physics achievements of women throughout the world, networking toward new international collaborations, building each participant's capacity for career success, and aiding the formation of active regional working groups to advance women in physics. Despite the progress, women remain a small minority of the physics community in most countries.

  7. Proceedings of the third USGS modeling conference, June 7-11, 2010, Broomfield, Colorado-Understanding and predicting for a changing world

    USGS Publications Warehouse

    Brady, Shailaja R.

    2011-01-01

    The Third USGS Modeling Conference was held June 7th-11, 2010, in Broomfield, Colorado. The conference focused on the development and application of analytical and theoretical models and data availability that support managing the Nation's resources and help protect lives and property. Participants at the conference included scientists and managers from Department of the Interior (DOI) Bureaus; national and international Federal, State, and local agencies; academic institutions; and nongovernmental organizations. The conference was organized according to DOI priorities and the strategic directions of the USGS Science Strategy; the following themes were emphasized: (1) Understanding Ecosystems and Restoring America's Treasured Landscapes; (2) Climate Change and Impact; (3) New Energy Frontier and Minerals for America; (4) A National Hazards, Risk, and Resilience Assessment Program; (5) Role of Environment and Wildlife in Human Health; (6) A Water Census of the United States; and (7) New Methods of Investigation and Discovery. The conference theme-"Understanding and Predicting for a Changing World"-focused on the following goals: advance development and application of models; provide tools that address management issues; present state-of-the-art models ranging from individual phenomena to integrated systems; and foster a working community among scientists and managers.

  8. Thermal storage wall model development in the DOE-2 computer program

    SciTech Connect

    Moore, J.E.; Schnurr, N.M.; Kerrisk, J.F.; Hunn, B.D.

    1981-01-01

    The DOE-2 building energy analysis computer program is being modified by the Los Alamos National Laboratory to include thermal storage wall modeling capabilities. This paper discusses model development and validation for vented and unvented thermal storage walls and water walls in DOE-2. The unvented wall model was validated by comparison with test-cell heating loads for both a selective surface and a night-insulated wall. The two commonly used vented wall models, the Akbari and Borgers correlations and the Bernoulli equation algorithm, were compared and tested against available wall performance data. The Bernoulli algorithm was chosen for use in DOE-2 because of its ability to simulate vent restrictions.

  9. Applications of GIS to the modeling of nonpoint source pollutants in the vadose zone: A conference overview

    SciTech Connect

    Corwin, D.L.; Wagenet, R.J.

    1996-05-01

    Because of their unbiquitous nature and potential chronic health effects, nonpoint source (NPS) pollutants have become a focal point of attention by the general public, particularly regarding pollution of surface and subsurface drinking water sources. The NPS pollutants pose a technical problem because of the areal extent of their contamination that increases the complexity and sheer volume of data far beyond that of point-source pollutants. The spatial nature of the NPS pollution problem necessitates the use of a geographic information system (GIS) to manipulate, retrieve, and display the large volumes of spatial data. This overview provides a brief introduction and review of the modeling of NPS pollutants with GIS and a brief discussion of some of the papers presented at the ASA-CSSA-SSSA 1995 Bouyoucos Conference entitled Applications of GIS to the Modeling of Nonpoint Source Pollutants in the Vadose Zone. 80 refs.

  10. ANNOUNCEMENT FOR THE THIRD INTERNATIONAL CONFERENCE ON THE ANALYTIC ELEMENT METHOD IN MODELING GROUNDWATER FLOW, BRAINERD, MN, APRIL 17-20, 2000

    EPA Science Inventory

    Brochure announcing the Third International Conference on the Analytic Element Method in Modeling Groundwater Flow which will be held in Brainerd, MN, April 17-19, 2000. .The 2000 ICAEM will bring together the academic and engineer perspectives in modeling groundwater flow for en...

  11. Does model performance improve with complexity? A case study with three hydrological models

    NASA Astrophysics Data System (ADS)

    Orth, Rene; Staudinger, Maria; Seneviratne, Sonia I.; Seibert, Jan; Zappa, Massimiliano

    2015-04-01

    In recent decades considerable progress has been made in climate model development. Following the massive increase in computational power, models became more sophisti- cated. At the same time also simple conceptual models have advanced. In this study we validate and compare three hydrological models of different complexity to investigate whether their performance varies accordingly. For this purpose we use runoff and also soil moisture measurements, which allow a truly independent validation, from several sites across Switzerland. The models are calibrated in similar ways with the same runoff data. Our results show that the more complex models HBV and PREVAH outperform the simple water balance model (SWBM) in case of runoff but not for soil moisture. Furthermore the most sophisticated PREVAH model shows an added value compared to the HBV model only in case of soil moisture. Focusing on extreme events we find generally improved performance of the SWBM during drought conditions and degraded agreement with observations during wet extremes. For the more complex models we find the opposite behavior, probably because they were primarily developed for predic- tion of runoff extremes. As expected given their complexity, HBV and PREVAH have more problems with over-fitting. All models show a tendency towards better perfor- mance in lower altitudes as opposed to (pre-)alpine sites. The results vary considerably across the investigated sites. In contrast, the different metrics we consider to estimate the agreement between models and observations lead to similar conclusions, indicating that the performance of the considered models is similar at different time scales as well as for anomalies and long-term means. We conclude that added complexity does not necessarily lead to improved performance of hydrological models, and that performance can vary greatly depending on the considered hydrological variable (e.g. runoff vs. soil moisture) or hydrological conditions (floods vs

  12. Does model performance improve with complexity? A case study with three hydrological models

    NASA Astrophysics Data System (ADS)

    Orth, Rene; Staudinger, Maria; Seneviratne, Sonia I.; Seibert, Jan; Zappa, Massimiliano

    2015-04-01

    In recent decades considerable progress has been made in climate model development. Following the massive increase in computational power, models became more sophisticated. At the same time also simple conceptual models have advanced. In this study we validate and compare three hydrological models of different complexity to investigate whether their performance varies accordingly. For this purpose we use runoff and also soil moisture measurements, which allow a truly independent validation, from several sites across Switzerland. The models are calibrated in similar ways with the same runoff data. Our results show that the more complex models HBV and PREVAH outperform the simple water balance model (SWBM) in case of runoff but not for soil moisture. Furthermore the most sophisticated PREVAH model shows an added value compared to the HBV model only in case of soil moisture. Focusing on extreme events we find generally improved performance of the SWBM during drought conditions and degraded agreement with observations during wet extremes. For the more complex models we find the opposite behavior, probably because they were primarily developed for prediction of runoff extremes. As expected given their complexity, HBV and PREVAH have more problems with over-fitting. All models show a tendency towards better performance in lower altitudes as opposed to (pre-) alpine sites. The results vary considerably across the investigated sites. In contrast, the different metrics we consider to estimate the agreement between models and observations lead to similar conclusions, indicating that the performance of the considered models is similar at different time scales as well as for anomalies and long-term means. We conclude that added complexity does not necessarily lead to improved performance of hydrological models, and that performance can vary greatly depending on the considered hydrological variable (e.g. runoff vs. soil moisture) or hydrological conditions (floods vs. droughts).

  13. Biomedical Conferences

    NASA Technical Reports Server (NTRS)

    1976-01-01

    As a result of Biomedical Conferences, Vivo Metric Systems Co. has produced cardiac electrodes based on NASA technology. Frequently in science, one highly specialized discipline is unaware of relevant advances made in other areas. In an attempt to familiarize researchers in a variety of disciplines with medical problems and needs, NASA has sponsored conferences that bring together university scientists, practicing physicians and manufacturers of medical instruments.

  14. Architecture of conference control functions

    NASA Astrophysics Data System (ADS)

    Kausar, Nadia; Crowcroft, Jon

    1999-11-01

    Conference control is an integral part in many-to-many communications that is used to manage and co-ordinate multiple users in conferences. There are different types of conferences which require different types of control. Some of the features of conference control may be user invoked while others are for internal management of a conference. In recent years, ITU (International Telecommunication Union) and IETF (Internet Engineering Task Force) have standardized two main models of conferencing, each system providing a set of conference control functionalities that are not easily provided in the other one. This paper analyzes the main activities appropriate for different types of conferences and presents an architecture for conference control called GCCP (Generic Conference Control Protocol). GCCP interworks different types of conferencing and provides a set of conference control functions that can be invoked by users directly. As an example of interworking, interoperation of IETF's SIP and ITU's H.323 call control functions have been examined here. This paper shows that a careful analysis of a conferencing architecture can provide a set of control functions essential for any group communication model that can be extensible if needed.

  15. Eleventh annual U.S. DOE low-level radioactive waste management conference: Executive summary, opening plenary, technical session summaries, and attendees

    SciTech Connect

    1990-01-01

    The conference consisted of ten technical sessions, with three sessions running simultaneously each day. Session topics included: regulatory updates; performance assessment;understanding remedial action efforts; low-level waste strategy and planning (Nuclear Energy); low-level waste strategy and planning (Defense); compliance monitoring; decontamination and decommissioning; waste characterization; waste reduction and minimization; and prototype licensing application workshop. Summaries are presented for each of these sessions.

  16. Common Challenges for Ecological Modelling: Synthesis of Facilitated Discussions Held at the Symposia Organized for the Conference of the International Society for Ecological Modelling in Quebec City, Canada (October 6-9, 2009)

    EPA Science Inventory

    The symposia organized for the conference of the International Society for Ecological Modelling (ISEM 2009) included facilitated discussion sessions following formal presentations. Each symposium focused on a specific subject, and all the subjects could be classified into three b...

  17. Learning from Video Modeling Examples: Does Gender Matter?

    ERIC Educational Resources Information Center

    Hoogerheide, Vincent; Loyens, Sofie M. M.; van Gog, Tamara

    2016-01-01

    Online learning from video modeling examples, in which a human model demonstrates and explains how to perform a learning task, is an effective instructional method that is increasingly used nowadays. However, model characteristics such as gender tend to differ across videos, and the model-observer similarity hypothesis suggests that such…

  18. 2012 CELLULAR & MOLECULAR FUNGAL BIOLOGY GORDON RESEARCH CONFERENCE, JUNE 17 - 22, 2012

    SciTech Connect

    Judith Berman

    2012-06-22

    The Gordon Research Conference on CELLULAR & MOLECULAR FUNGAL BIOLOGY was held at Holderness School, Holderness New Hampshire, June 17 - 22, 2012. The 2012 Gordon Conference on Cellular and Molecular Fungal Biology (CMFB) will present the latest, cutting-edge research on the exciting and growing field of molecular and cellular aspects of fungal biology. Topics will range from yeast to filamentous fungi, from model systems to economically important organisms, and from saprophytes and commensals to pathogens of plants and animals. The CMFB conference will feature a wide range of topics including systems biology, cell biology and morphogenesis, organismal interactions, genome organisation and regulation, pathogenesis, energy metabolism, biomass production and population genomics. The Conference was well-attended with 136 participants. Gordon Research Conferences does not permit publication of meeting proceedings.

  19. When Does Model-Based Control Pay Off?

    PubMed

    Kool, Wouter; Cushman, Fiery A; Gershman, Samuel J

    2016-08-01

    Many accounts of decision making and reinforcement learning posit the existence of two distinct systems that control choice: a fast, automatic system and a slow, deliberative system. Recent research formalizes this distinction by mapping these systems to "model-free" and "model-based" strategies in reinforcement learning. Model-free strategies are computationally cheap, but sometimes inaccurate, because action values can be accessed by inspecting a look-up table constructed through trial-and-error. In contrast, model-based strategies compute action values through planning in a causal model of the environment, which is more accurate but also more cognitively demanding. It is assumed that this trade-off between accuracy and computational demand plays an important role in the arbitration between the two strategies, but we show that the hallmark task for dissociating model-free and model-based strategies, as well as several related variants, do not embody such a trade-off. We describe five factors that reduce the effectiveness of the model-based strategy on these tasks by reducing its accuracy in estimating reward outcomes and decreasing the importance of its choices. Based on these observations, we describe a version of the task that formally and empirically obtains an accuracy-demand trade-off between model-free and model-based strategies. Moreover, we show that human participants spontaneously increase their reliance on model-based control on this task, compared to the original paradigm. Our novel task and our computational analyses may prove important in subsequent empirical investigations of how humans balance accuracy and demand. PMID:27564094

  20. When Does Model-Based Control Pay Off?

    PubMed Central

    2016-01-01

    Many accounts of decision making and reinforcement learning posit the existence of two distinct systems that control choice: a fast, automatic system and a slow, deliberative system. Recent research formalizes this distinction by mapping these systems to “model-free” and “model-based” strategies in reinforcement learning. Model-free strategies are computationally cheap, but sometimes inaccurate, because action values can be accessed by inspecting a look-up table constructed through trial-and-error. In contrast, model-based strategies compute action values through planning in a causal model of the environment, which is more accurate but also more cognitively demanding. It is assumed that this trade-off between accuracy and computational demand plays an important role in the arbitration between the two strategies, but we show that the hallmark task for dissociating model-free and model-based strategies, as well as several related variants, do not embody such a trade-off. We describe five factors that reduce the effectiveness of the model-based strategy on these tasks by reducing its accuracy in estimating reward outcomes and decreasing the importance of its choices. Based on these observations, we describe a version of the task that formally and empirically obtains an accuracy-demand trade-off between model-free and model-based strategies. Moreover, we show that human participants spontaneously increase their reliance on model-based control on this task, compared to the original paradigm. Our novel task and our computational analyses may prove important in subsequent empirical investigations of how humans balance accuracy and demand. PMID:27564094

  1. Brucella abortus ΔrpoE1 confers protective immunity against wild type challenge in a mouse model of brucellosis.

    PubMed

    Willett, Jonathan W; Herrou, Julien; Czyż, Daniel M; Cheng, Jason X; Crosson, Sean

    2016-09-30

    The Brucella abortus general stress response (GSR) system regulates activity of the alternative sigma factor, σ(E1), which controls transcription of approximately 100 genes and is required for persistence in a BALB/c mouse chronic infection model. We evaluated the host response to infection by a B. abortus strain lacking σ(E1) (ΔrpoE1), and identified pathological and immunological features that distinguish ΔrpoE1-infected mice from wild-type (WT), and that correspond with clearance of ΔrpoE1 from the host. ΔrpoE1 infection was indistinguishable from WT in terms of splenic bacterial burden, inflammation and histopathology up to 6weeks post-infection. However, Brucella-specific serum IgG levels in ΔrpoE1-infected mice were 5 times higher than WT by 4weeks post-infection, and remained significantly higher throughout the course of a 12-week infection. Total IgG and Brucella-specific IgG levels peaked strongly in ΔrpoE1-infected mice at 6weeks, which correlated with reduced splenomegaly and bacterial burden relative to WT-infected mice. Given the difference in immune response to infection with wild-type and ΔrpoE1, we tested whether ΔrpoE1 confers protective immunity to wild-type challenge. Mice immunized with ΔrpoE1 completely resisted WT infection and had significantly higher serum titers of Brucella-specific IgG, IgG2a and IFN-γ after WT challenge relative to age-matched naïve mice. We conclude that immunization of BALB/c mice with the B. abortus GSR pathway mutant, ΔrpoE1, elicits an adaptive immune response that confers significant protective immunity against WT infection.

  2. A Proposal submitted to Biological Systems Science Division of DOE requesting Participant Support Costs for the Fifth International Conference on Polar and Alpine Microbiology

    SciTech Connect

    Priscu, John

    2012-11-20

    The 5th International Conference on Polar and Alpine Microbiology (PAM5) was held in Big Sky, Montana (USA) from 8-12 September 2013. This meeting is a continuation of the highly successful meetings previously held in Rovaniemi, Finland (2004), Innsbruck, Austria (2006), Banff, Canada (2008) and Ljubljana, Slovenia (2011), which brought together leading international researchers and students in this field. The objectives of the Big Sky meeting were to bring together scientists, students and professionals to discuss all aspects of cold-adapted microorganisms and the roles they play in polar and alpine environments, to understand the role of these organisms in our search for life on other icy worlds, to address recent developments, and to exchange ideas and experiences on an international scale. The conference provided a multi-disciplinary forum to explore emerging areas in the field and as always, will have a wealth of opportunities for the exchange of ideas and building of collaborations. Funds were requested to help defray registration fees and travel costs of 13 early career scientists. Distribution of the funds were based on the quality of the abstracts submitted.

  3. Does the Interpersonal Model Generalize to Obesity Without Binge Eating?

    PubMed

    Lo Coco, Gianluca; Sutton, Rachel; Tasca, Giorgio A; Salerno, Laura; Oieni, Veronica; Compare, Angelo

    2016-09-01

    The interpersonal model has been validated for binge eating disorder (BED), but it is not yet known if the model applies to individuals who are obese but who do not binge eat. The goal of this study was to compare the validity of the interpersonal model in those with BED versus those with obesity, and normal weight samples. Data from a sample of 93 treatment-seeking women diagnosed with BED, 186 women who were obese without BED, and 100 controls who were normal weight were examined for indirect effects of interpersonal problems on binge eating psychopathology mediated through negative affect. Findings demonstrated the mediating role of negative affect for those with BED and those who were obese without BED. Testing a reverse model suggested that the interpersonal model is specific for BED but that this model may not be specific for those without BED. This is the first study to find support for the interpersonal model in a sample of women with obesity but who do not binge. However, negative affect likely plays a more complex role in determining overeating in those with obesity but who do not binge. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.

  4. Does the Interpersonal Model Generalize to Obesity Without Binge Eating?

    PubMed

    Lo Coco, Gianluca; Sutton, Rachel; Tasca, Giorgio A; Salerno, Laura; Oieni, Veronica; Compare, Angelo

    2016-09-01

    The interpersonal model has been validated for binge eating disorder (BED), but it is not yet known if the model applies to individuals who are obese but who do not binge eat. The goal of this study was to compare the validity of the interpersonal model in those with BED versus those with obesity, and normal weight samples. Data from a sample of 93 treatment-seeking women diagnosed with BED, 186 women who were obese without BED, and 100 controls who were normal weight were examined for indirect effects of interpersonal problems on binge eating psychopathology mediated through negative affect. Findings demonstrated the mediating role of negative affect for those with BED and those who were obese without BED. Testing a reverse model suggested that the interpersonal model is specific for BED but that this model may not be specific for those without BED. This is the first study to find support for the interpersonal model in a sample of women with obesity but who do not binge. However, negative affect likely plays a more complex role in determining overeating in those with obesity but who do not binge. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association. PMID:27383030

  5. Conference Summary

    NASA Technical Reports Server (NTRS)

    Harrington, James L., Jr.

    2000-01-01

    Celebrations and special events were in order this year as the Minority University-Space Interdisciplinary Network (MU-SPIN) Program and NASA's Minority University Research and Education Division (MURED) both reached their 10th anniversaries. In honor of this occasion, the 2000 Annual Users' Conference held at Morris Brown College (MBC) in Atlanta, Georgia, September 11-15, 2000, was the first to be jointly hosted by MU-SPIN and MURED. It was particularly fitting that this anniversary should fall in the year 2000. The start of the new millennium propelled us to push bold new ideas and renew our commitment to minority university participation in all areas of NASA. With the theme 'Celebrating Our Tenth Year With Our Eyes on the Prize,' the conference provided a national forum for showcasing successful MU-SPIN and MURED Program (MUREP) experiences to enhance faculty/student development in areas of scientific and technical research and education. Our NASA-relevant conference agenda resulted in a record-breaking 220 registered attendees. Using feedback from past participants, we designed a track of student activities closely tailored to their interests. The resulting showcase of technical assistance and best practices set a new standard for our conferences in the years to come. This year's poster session was our largest ever, with over 50 presentations from students, faculty, and teachers. Posters covered a broad range of NASA activities from 'A Study of the Spiral Galaxy M101' to 'Network Cabling Characteristics.'

  6. Why does inverse modeling of drainage inventories work?

    NASA Astrophysics Data System (ADS)

    White, Nicky; Roberts, Gareth

    2016-04-01

    We describe and apply a linear inverse model which calculates spatial and temporal patterns of uplift rate by minimizing the misfit between inventories of observed and predicted longitudinal river profiles. This approach builds upon a more general, non-linear, optimization model, which suggests that shapes of river profiles are dominantly controlled by upstream advection of kinematic waves of incision produced by spatial and temporal changes in regional uplift rate. We have tested both algorithms by inverting thousands of river profiles from Africa, Eurasia, the Americas, and Australia. For each continent, the drainage network was constructed from a digital elevation model and the fidelity of river profiles extracted from this network was carefully checked using satellite imagery. Spatial and temporal patterns of both uplift rate and cumulative uplift were calibrated using independent geologic and geophysical observations. Inverse modeling of these substantial inventories of river profiles suggests that drainage networks contain coherent signals that record the regional growth of elevation. In the second part of this presentation, we use spectral analysis of river profiles to suggest why drainage networks behave in a coherent, albeit non-linear, fashion. Our analysis implies that large-scale topographic signals injected into landscapes generate spectral slopes that are usually red (i.e. Brownian). At wavelengths shorter than tens of km, spectral slopes whiten which suggests that coherent topographic signals cease to exist at these shorter length scales. Our results suggest that inverse modeling of drainage networks can reveal useful information about landscape growth through space and time.

  7. Predicting Attrition in Admissions Using a Discriminant Model. SAIR Conference Paper.

    ERIC Educational Resources Information Center

    Yost, Michael

    A mathematical model designed to identify admitted college applicants who pay a tuition deposit but fail to attend the college was tested. A two-group discriminant model was built using 486 Trinity University students who paid deposits and enrolled as freshmen during the 1983-1984 academic year, and 72 persons who paid tuition deposits but did not…

  8. How does spreading depression spread? Physiology and modeling.

    PubMed

    Zandt, Bas-jan; ten Haken, Bennie; van Putten, Michel J A M; Dahlem, Markus A

    2015-01-01

    Spreading depression (SD) is a wave phenomenon in gray matter tissue. Locally, it is characterized by massive redistribution of ions across cell membranes. As a consequence, there is sustained membrane depolarization and tissue polarization that depress any normal electrical activity. Despite these dramatic events, SD remains difficult to observe in humans noninvasively, which, for long, has slowed advances in this field. The growing appreciation of its clinical importance in migraine and stroke is therefore consistent with an increasing need for computational methods that tackle the complexity of the problem at multiple levels. In this review, we focus on mathematical tools to investigate the question of spread and its two complementary aspects: What are the physiological mechanisms and what is the spatial extent of SD in the cortex? This review discusses two types of models used to study these two questions, namely, Hodgkin-Huxley type and generic activator-inhibitor models, and the recent advances in techniques to link them.

  9. Modeling nitrogen fluxes in Germany - where does the nitrogen go?

    NASA Astrophysics Data System (ADS)

    Klement, Laura; Bach, Martin; Breuer, Lutz

    2016-04-01

    According to the latest inventory of the EU Water Framework Directive, 26.3% of German groundwater bodies are in a poor chemical state regarding nitrate. Additionally, the EU initiated infringement proceedings against Germany for not meeting the quality standards of the EU Nitrate Directive. Agriculture has been determined as the main source of nitrate pollution due to over-fertilization and regionally high density of livestock farming. The nitrogen balance surplus is commonly used as an indicator characterizing the potential of nitrate leaching into groundwater bodies and thus also serves as a foundation to introduce legislative restrictions or to monitor the success of mitigation measures. Currently, there is an ongoing discussion which measures are suitable for reducing the risk of nitrate leaching and also to what extent. However, there is still uncertainty about just how much the nitrogen surplus has to be reduced to meet the groundwater quality standards nationwide. Therefore, the aims of our study were firstly to determine the level of the nitrogen surplus that would be acceptable at the utmost and secondly whether the currently discussed target value of 30 kg N per hectare agricultural land for the soil surface nitrogen balance would be sufficient. The models MONERIS (Modeling Nutrient Emissions in River System) and MoRE (Modelling of Regionalized Emissions), the latter based on the first, are commonly used for estimating nitrogen loads into the river system in Germany at the mesoscale, as well as the effect of mitigation measures in the context of the EU directive 2008/105/EC (Environmental quality standards applicable to surface water). We used MoRE to calculate nitrate concentration for 2759 analytical units in Germany. Main factors are the surplus of the soil surface nitrogen balance, the percolation rate and an exponent representing the denitrification in the vadose zone. The modeled groundwater nitrate concentrations did not correspond to the regional

  10. How does spreading depression spread? Physiology and modeling.

    PubMed

    Zandt, Bas-jan; ten Haken, Bennie; van Putten, Michel J A M; Dahlem, Markus A

    2015-01-01

    Spreading depression (SD) is a wave phenomenon in gray matter tissue. Locally, it is characterized by massive redistribution of ions across cell membranes. As a consequence, there is sustained membrane depolarization and tissue polarization that depress any normal electrical activity. Despite these dramatic events, SD remains difficult to observe in humans noninvasively, which, for long, has slowed advances in this field. The growing appreciation of its clinical importance in migraine and stroke is therefore consistent with an increasing need for computational methods that tackle the complexity of the problem at multiple levels. In this review, we focus on mathematical tools to investigate the question of spread and its two complementary aspects: What are the physiological mechanisms and what is the spatial extent of SD in the cortex? This review discusses two types of models used to study these two questions, namely, Hodgkin-Huxley type and generic activator-inhibitor models, and the recent advances in techniques to link them. PMID:25719306

  11. Constitutive Relationships and Models in Continuum Theories of Multiphase Flows. [conferences

    NASA Technical Reports Server (NTRS)

    Decker, Rand (Editor)

    1989-01-01

    In April, 1989, a workshop on constitutive relationships and models in continuum theories of multiphase flows was held at NASA's Marshall Space Flight Center. Topics of constitutive relationships for the partial or per phase stresses, including the concept of solid phase pressure are discussed. Models used for the exchange of mass, momentum, and energy between the phases in a multiphase flow are also discussed. The program, abstracts, and texts of the presentations from the workshop are included.

  12. Making Conferences Human Places of Learning

    ERIC Educational Resources Information Center

    Kenny, Michael

    2014-01-01

    Open Space Technology is a cumbersome name for a participative conference model that enables dynamic inclusive engagement and challenges traditional, highly structured hierarchical conference formats. Based on self-organising systems, (Wenger, 1998) Open Space Technology conferences have an open process, start with no agenda and empower the most…

  13. Conference-Courses for Academic Credit.

    ERIC Educational Resources Information Center

    Bobes, Marvin

    1979-01-01

    The Wayne State University Studies/Weekend College Program demonstrates a cost effective, flexible model for conference courses. Designed to give adult, part-time students short-term intensive learning experiences, the conference course adapts typical conference activities (guest speakers, films, workshops) to a single or multidisciplinary theme,…

  14. Using a Consensus Conference to Characterize Regulatory Concerns Regarding Bioremediation of Radionuclides and Heavy Metals in Mixed Waste at DOE Sites

    SciTech Connect

    Denise Lach; Stephanie Sanford

    2006-09-01

    A consensus workshop was developed and convened with ten state regulators to characterize concerns regarding emerging bioremediation technology to be used to clean-up radionuclides and heavy metals in mixed wastes at US DOE sites. Two questions were explored: integrated questions: (1) What impact does participation in a consensus workshop have on the knowledge, attitudes, and practices of state regulators regarding bioremediation technology? (2) How effective is a consensus workshop as a strategy for eliciting and articulating regulators’ concerns regarding the use of bioremediation to clean up radionuclides and heavy metals in mixed wastes at U.S. Department of Energy Sites around the county? State regulators met together for five days over two months to learn about bioremediation technology and develop a consensus report of their recommendations regarding state regulatory concerns. In summary we found that panel members: - quickly grasped the science related to bioremediation and were able to effectively interact with scientists working on complicated issues related to the development and implementation of the technology; - are generally accepting of in situ bioremediation, but concerned about costs, implementation (e.g., institutional controls), and long-term effectiveness of the technology; - are concerned equally about technological and implementation issues; and - believed that the consensus workshop approach to learning about bioremediation was appropriate and useful. Finally, regulators wanted decision makers at US DOE to know they are willing to work with DOE regarding innovative approaches to clean-up at their sites, and consider a strong relationship between states and the DOE as critical to any effective clean-up. They do not want perceive themselves to be and do not want others to perceive them as barriers to successful clean-up at their sites.

  15. A Short Commentary on "Where Does Creativity Fit into a Productivist Industrial Model of Knowledge Production?"

    ERIC Educational Resources Information Center

    Gentry, Marcia

    2010-01-01

    This article presents the author's brief comment on Hisham B. Ghassib's "Where Does Creativity Fit into a Productivist Industrial Model of Knowledge Production?" Ghassib (2010) takes the reader through an interesting history of human innovation and processes and situates his theory within a productivist model. The deliberate attention to…

  16. How many parameters does a quark mass matrix model need

    SciTech Connect

    Koide, Y. )

    1990-11-01

    An investigation independent of matrix form is made of how many parameters, which characterize the difference between up- and down-quark mass matrices, are, at least, required from the present data on quark masses and mixings. From a general study of the model with hierarchical three-step mass generations described by the three parameters {alpha}{sub {ital q}}, {beta}{sub {ital q}}, and {gamma}{sub {ital q}} ({vert bar}{alpha}{sub {ital q}}{vert bar}{much gt}{vert bar}{beta}{sub {ital q}}{vert bar}{much gt}{vert bar}{gamma}{sub {ital q}}{vert bar}; {ital q}={ital u},{ital d}), it is pointed out that the model with {beta}{sub {ital u}}/{beta}{sub {ital d}}={gamma}{sub {ital u}}/{gamma}{sub {ital d}} (i.e., with two independent parameters {alpha}{sub {ital q}} and {beta}{sub {ital q}}) is ruled out.

  17. A model for oxygen-dependent backscattering spectroscopic contrast from single red blood cells (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Liu, Rongrong; Yi, Ji; Chen, Siyu; Zhang, Hao F.; Backman, Vadim

    2016-03-01

    The oxygen-dependent absorption of hemoglobin provides the fundamental contrast for all label-free techniques measuring blood oxygenation. When hemoglobin is packaged into red blood cells (RBCs), the structure of the cells creates light scattering which also depends on the absorption based on the Kramers-Kronig relationship. Thus a proper characterization of the optical behaviors of blood has been a key to any accurate measurement of blood oxygenation, particularly at the capillary level where RBCs are dispersed individually in contrast to a densely packed whole blood. Here we provided a theoretical model under Born Approximation to characterize the oxygen dependent backscattering spectroscopic contrast from single RBCs. Using this theoretical model, we conducted simulations on both oxygenated and deoxygenated single RBCs with different sizes for standard and possible deformed cell geometries in blood flow, all which suggested similar backscattering spectroscopic contrast and were confirmed by Mie Theory and experiments using visible Optical Coherence Tomography (visOCT). As long as the cell size satisfies Gaussian distribution with a coefficient variance (C.V.) large enough, there is clear absorption contrast between the backscattering spectra of oxygenated and deoxygenated single RBCs calculated by this model, so oxygen saturation can then be characterized. Thus, this theoretical model can be extended to extract absorption features of other scattering particles as long as they satisfy Born Approximation.

  18. A Guide to Staff Development Activities, Using a Florida Conference as a Model.

    ERIC Educational Resources Information Center

    Tuttle, Lester E., Jr., Ed.; Ciccone, Russell A., Ed.

    Staff development activities are the subject of a resource guide directed at educators of migrant children. One county participating in the Florida Migratory Child Compensatory Program was selected to serve as a model. Planning for activities should be individually-based, problem-oriented, goal-directed, time-factored, and participant-controlled.…

  19. A Model for Linking Organizational Culture and Performance. Innovative Session 6. [AHRD Conference, 2001].

    ERIC Educational Resources Information Center

    McCullough, Cathy Bolton

    An innovative session was conducted to introduce session participants to a concept and researched model for linking organizational culture and performance. The session goals were as follows: (1) give participants a working knowledge of the link between business culture and key business performance indicators; (2) give participants a hands-on…

  20. Does Your Model Weigh the Same as a Duck?

    PubMed Central

    Jain, Ajay N.; Cleves, Ann E.

    2012-01-01

    Computer-aided drug design is a mature field by some measures, and it has produced notable successes that underpin the study of interactions between small molecules and living systems. However, unlike a truly mature field, fallacies of logic lie at the heart of the arguments in support of major lines of research on methodology and validation thereof. Two particularly pernicious ones are cum hoc ergo propter hoc (with this, therefore because of this) and confirmation bias (seeking evidence that is confirmatory of the hypothesis at hand). These fallacies will be discussed in the context of off-target predictive modeling, QSAR, molecular similarity computations, and docking. Examples will be shown that avoid these problems. PMID:22187141

  1. Impairment of O-antigen production confers resistance to grazing in a model amoeba-cyanobacterium predator-prey system.

    PubMed

    Simkovsky, Ryan; Daniels, Emy F; Tang, Karen; Huynh, Stacey C; Golden, Susan S; Brahamsha, Bianca

    2012-10-01

    The grazing activity of predators on photosynthetic organisms is a major mechanism of mortality and population restructuring in natural environments. Grazing is also one of the primary difficulties in growing cyanobacteria and other microalgae in large, open ponds for the production of biofuels, as contaminants destroy valuable biomass and prevent stable, continuous production of biofuel crops. To address this problem, we have isolated a heterolobosean amoeba, HGG1, that grazes upon unicellular and filamentous freshwater cyanobacterial species. We have established a model predator-prey system using this amoeba and Synechococcus elongatus PCC 7942. Application of amoebae to a library of mutants of S. elongatus led to the identification of a grazer-resistant knockout mutant of the wzm ABC O-antigen transporter gene, SynPCC7942_1126. Mutations in three other genes involved in O-antigen synthesis and transport also prevented the expression of O-antigen and conferred resistance to HGG1. Complementation of these rough mutants returned O-antigen expression and susceptibility to amoebae. Rough mutants are easily identifiable by appearance, are capable of autoflocculation, and do not display growth defects under standard laboratory growth conditions, all of which are desired traits for a biofuel production strain. Thus, preventing the production of O-antigen is a pathway for producing resistance to grazing by certain amoebae.

  2. Impairment of O-antigen production confers resistance to grazing in a model amoeba-cyanobacterium predator-prey system.

    PubMed

    Simkovsky, Ryan; Daniels, Emy F; Tang, Karen; Huynh, Stacey C; Golden, Susan S; Brahamsha, Bianca

    2012-10-01

    The grazing activity of predators on photosynthetic organisms is a major mechanism of mortality and population restructuring in natural environments. Grazing is also one of the primary difficulties in growing cyanobacteria and other microalgae in large, open ponds for the production of biofuels, as contaminants destroy valuable biomass and prevent stable, continuous production of biofuel crops. To address this problem, we have isolated a heterolobosean amoeba, HGG1, that grazes upon unicellular and filamentous freshwater cyanobacterial species. We have established a model predator-prey system using this amoeba and Synechococcus elongatus PCC 7942. Application of amoebae to a library of mutants of S. elongatus led to the identification of a grazer-resistant knockout mutant of the wzm ABC O-antigen transporter gene, SynPCC7942_1126. Mutations in three other genes involved in O-antigen synthesis and transport also prevented the expression of O-antigen and conferred resistance to HGG1. Complementation of these rough mutants returned O-antigen expression and susceptibility to amoebae. Rough mutants are easily identifiable by appearance, are capable of autoflocculation, and do not display growth defects under standard laboratory growth conditions, all of which are desired traits for a biofuel production strain. Thus, preventing the production of O-antigen is a pathway for producing resistance to grazing by certain amoebae. PMID:23012457

  3. Impairment of O-antigen production confers resistance to grazing in a model amoeba–cyanobacterium predator–prey system

    PubMed Central

    Simkovsky, Ryan; Daniels, Emy F.; Tang, Karen; Huynh, Stacey C.; Golden, Susan S.; Brahamsha, Bianca

    2012-01-01

    The grazing activity of predators on photosynthetic organisms is a major mechanism of mortality and population restructuring in natural environments. Grazing is also one of the primary difficulties in growing cyanobacteria and other microalgae in large, open ponds for the production of biofuels, as contaminants destroy valuable biomass and prevent stable, continuous production of biofuel crops. To address this problem, we have isolated a heterolobosean amoeba, HGG1, that grazes upon unicellular and filamentous freshwater cyanobacterial species. We have established a model predator–prey system using this amoeba and Synechococcus elongatus PCC 7942. Application of amoebae to a library of mutants of S. elongatus led to the identification of a grazer-resistant knockout mutant of the wzm ABC O-antigen transporter gene, SynPCC7942_1126. Mutations in three other genes involved in O-antigen synthesis and transport also prevented the expression of O-antigen and conferred resistance to HGG1. Complementation of these rough mutants returned O-antigen expression and susceptibility to amoebae. Rough mutants are easily identifiable by appearance, are capable of autoflocculation, and do not display growth defects under standard laboratory growth conditions, all of which are desired traits for a biofuel production strain. Thus, preventing the production of O-antigen is a pathway for producing resistance to grazing by certain amoebae. PMID:23012457

  4. Imaging and modeling of collagen architecture in living tissue with polarized light transfer (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Ramella-Roman, Jessica C.; Stoff, Susan; Chue-Sang, Joseph; Bai, Yuqiang

    2016-03-01

    The extra-cellular space in connective tissue of animals and humans alike is comprised in large part of collagen. Monitoring of collagen arrangement and cross-linking has been utilized to diagnose a variety of medical conditions and guide surgical intervention. For example, collagen monitoring is useful in the assessment and treatment of cervical cancer, skin cancer, myocardial infarction, and non-arteritic anterior ischemic optic neuropathy. We have developed a suite of tools and models based on polarized light transfer for the assessment of collagen presence, cross-linking, and orientation in living tissue. Here we will present some example of such approach applied to the human cervix. We will illustrate a novel Mueller Matrix (MM) imaging system for the study of cervical tissue; furthermore we will show how our model of polarized light transfer through cervical tissue compares to the experimental findings. Finally we will show validation of the methodology through histological results and Second Harmonic imaging microscopy.

  5. 2012 BATTERIES GORDON RESEARCH CONFERENCE, MARCH 4-9, 2012

    SciTech Connect

    Stephen Harris

    2012-03-09

    The Gordon Research Conference on BATTERIES was held at Four Points Sheraton / Holiday Inn Express, Ventura, California, March 4-9, 2012. The Conference was well-attended with 176 participants. Gordon Research Conferences does not permit publication of meeting proceedings.

  6. Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction

    PubMed Central

    Noonan, Michele A.; Bulin, Sarah; Fuller, Dwain C.; Eisch, Amelia J.

    2010-01-01

    Drugs of abuse dynamically regulate adult neurogenesis, which appears important for some types of learning and memory. Interestingly, a major site of adult neurogenesis - the hippocampus - is important in the formation of drug-context associations and in the mediation of drug-taking and drug-seeking behaviors in animal models of addiction. Correlative evidence suggests an inverse relationship between hippocampal neurogenesis and drug-taking or drug-seeking behaviors, but the lack of a causative link has made the relationship between adult-generated neurons and addiction unclear. We used rat i.v. cocaine self-administration in rodents, a clinicall-relevant animal model of addiction, to test the hypothesis that suppression of adult hippocampal neurogenesis enhances vulnerability to addiction and relapse. Suppression of adult hippocampal neurogenesis via cranial irradiation before drug-taking significantly increased cocaine self-administration on both fixed-ratio and progressive-ratio schedules, as well as induced a vertical shift in the dose-response curve. This was not a general enhancement of learning, motivation or locomotion, as sucrose self-administration and locomotor activity were unchanged in irradiated rats. Suppression of adult hippocampal neurogenesis after drug-taking significantly enhanced resistance to extinction of drug-seeking behavior. These studies identify reduced adult hippocampal neurogenesis as a novel risk factor for addiction-related behaviors in an animal model of cocaine addiction. Further, they suggest that therapeutics to specifically increase or stabilize adult hippocampal neurogenesis could aid in preventing initial addiction as well as future relapse. PMID:20053911

  7. Four dimensional optoacoustic imaging of perfusion in preclinical breast tumor model in vivo (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Deán-Ben, Xosé Luís.; Ermolayev, Vladimir; Mandal, Subhamoy; Ntziachristos, Vasilis; Razansky, Daniel

    2016-03-01

    Imaging plays an increasingly important role in clinical management and preclinical studies of cancer. Application of optical molecular imaging technologies, in combination with highly specific contrast agent approaches, eminently contributed to understanding of functional and histological properties of tumors and anticancer therapies. Yet, optical imaging exhibits deterioration in spatial resolution and other performance metrics due to light scattering in deep living tissues. High resolution molecular imaging at the whole-organ or whole-body scale may therefore bring additional understanding of vascular networks, blood perfusion and microenvironment gradients of malignancies. In this work, we constructed a volumetric multispectral optoacoustic tomography (vMSOT) scanner for cancer imaging in preclinical models and explored its capacity for real-time 3D intravital imaging of whole breast cancer allografts in mice. Intrinsic tissue properties, such as blood oxygenation gradients, along with the distribution of externally administered liposomes carrying clinically-approved indocyanine green dye (lipo-ICG) were visualized in order to study vascularization, probe penetration and extravasation kinetics in different regions of interest within solid tumors. The use of v-MSOT along with the application of volumetric image analysis and perfusion tracking tools for studies of pathophysiological processes within microenvironment gradients of solid tumors demonstrated superior volumetric imaging system performance with sustained competitive resolution and imaging depth suitable for investigations in preclinical cancer models.

  8. Momentum transfer Monte Carlo model for the simulation of laser speckle contrast imaging (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Regan, Caitlin; Hayakawa, Carole K.; Choi, Bernard

    2016-03-01

    Laser speckle imaging (LSI) enables measurement of relative blood flow in microvasculature and perfusion in tissues. To determine the impact of tissue optical properties and perfusion dynamics on speckle contrast, we developed a computational simulation of laser speckle contrast imaging. We used a discrete absorption-weighted Monte Carlo simulation to model the transport of light in tissue. We simulated optical excitation of a uniform flat light source and tracked the momentum transfer of photons as they propagated through a simulated tissue geometry. With knowledge of the probability distribution of momentum transfer occurring in various layers of the tissue, we calculated the expected laser speckle contrast arising with coherent excitation using both reflectance and transmission geometries. We simulated light transport in a single homogeneous tissue while independently varying either absorption (.001-100mm^-1), reduced scattering (.1-10mm^-1), or anisotropy (0.05-0.99) over a range of values relevant to blood and commonly imaged tissues. We observed that contrast decreased by 49% with an increase in optical scattering, and observed a 130% increase with absorption (exposure time = 1ms). We also explored how speckle contrast was affected by the depth (0-1mm) and flow speed (0-10mm/s) of a dynamic vascular inclusion. This model of speckle contrast is important to increase our understanding of how parameters such as perfusion dynamics, vessel depth, and tissue optical properties affect laser speckle imaging.

  9. COMMENTS CONTRIBUTED BY ALAN HUBER TO AWMA AB-3 COMMITTEE FOR POSSIBLE INCLUSION IN THE COMMITTEE'S PRESENTATION AT EPA'S 8TH CONFERENCE ON AIR QUALITY MODELING - A&WMA AB-3 COMMENTS ON NONSTANDARD MODELING APPROACHES

    EPA Science Inventory

    Technical comments are provided to the Air and waste Management Associations AB-3 committee for potential inclusion into the committee's comments to be made at EPA's 8th Conference on Air Quality Modeling. Computational Fluid Dynamics (CFD) simulations can model specific cases wh...

  10. Modeling laser speckle imaging of perfusion in the skin (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Regan, Caitlin; Hayakawa, Carole K.; Choi, Bernard

    2016-02-01

    Laser speckle imaging (LSI) enables visualization of relative blood flow and perfusion in the skin. It is frequently applied to monitor treatment of vascular malformations such as port wine stain birthmarks, and measure changes in perfusion due to peripheral vascular disease. We developed a computational Monte Carlo simulation of laser speckle contrast imaging to quantify how tissue optical properties, blood vessel depths and speeds, and tissue perfusion affect speckle contrast values originating from coherent excitation. The simulated tissue geometry consisted of multiple layers to simulate the skin, or incorporated an inclusion such as a vessel or tumor at different depths. Our simulation used a 30x30mm uniform flat light source to optically excite the region of interest in our sample to better mimic wide-field imaging. We used our model to simulate how dynamically scattered photons from a buried blood vessel affect speckle contrast at different lateral distances (0-1mm) away from the vessel, and how these speckle contrast changes vary with depth (0-1mm) and flow speed (0-10mm/s). We applied the model to simulate perfusion in the skin, and observed how different optical properties, such as epidermal melanin concentration (1%-50%) affected speckle contrast. We simulated perfusion during a systolic forearm occlusion and found that contrast decreased by 35% (exposure time = 10ms). Monte Carlo simulations of laser speckle contrast give us a tool to quantify what regions of the skin are probed with laser speckle imaging, and measure how the tissue optical properties and blood flow affect the resulting images.

  11. ISOCT study of collagen crosslinking of collagen in cancer models (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Spicer, Graham; Young, Scott T.; Yi, Ji; Shea, Lonnie D.; Backman, Vadim

    2016-03-01

    The role of extracellular matrix modification and signaling in cancer progression is an increasingly recognized avenue for the progression of the disease. Previous study of field effect carcinogenesis with Inverse Spectroscopic Optical Coherence Tomography (ISOCT) has revealed pronounced changes in the nanoscale-sensitive mass fractal dimension D measured from field effect tissue when compared to healthy tissue. However, the origin of this difference in tissue ultrastructure in field effect carcinogenesis has remained poorly understood. Here, we present findings supporting the idea that enzymatic crosslinking of the extracellular matrix is an effect that presents at the earliest stages of carcinogenesis. We use a model of collagen gel with crosslinking induced by lysyl oxidase (LOXL4) to recapitulate the difference in D previously reported from healthy and cancerous tissue biopsies. Furthermore, STORM imaging of this collagen gel model verifies the morphologic effects of enzymatic crosslinking at length scales as small as 40 nm, close to the previously reported lower length scale sensitivity threshold of 35 nm for ISOCT. Analysis of the autocorrelation function from STORM images of collagen gels and subsequent fitting to the Whittle-Matérn correlation function shows a similar effect of LOXL4 on D from collagen measured with ISOCT and STORM. We extend this to mass spectrometric study of tissue to directly measure concentrations of collagen crosslink residues. The validation of ISOCT as a viable tool for non-invasive rapid quantification of collagen ultrastructure lends it to study other physiological phenomena involving ECM restructuring such as atherosclerotic plaque screening or cervical ripening during pregnancy.

  12. Next conference

    NASA Astrophysics Data System (ADS)

    Hexemer, Alexander; Toney, Michael F.

    2010-11-01

    After the successful conference on Synchrotron Radiation in Polymer Science (SRPS) in Rolduc Abbey (the Netherlands), we are now looking forward to the next meeting in this topical series started in 1995 by H G Zachmann, one of the pioneers of the use of synchrotron radiation techniques in polymer science. Earlier meetings were held in Hamburg (1995), Sheffield (2002), Kyoto (2006), and Rolduc (2009). In September of 2012 the Synchrotron Radiation and Polymer Science V conferences will be organized in a joint effort by the SLAC National Accelerator Laboratory and Lawrence Berkeley National Laboratory. Stanford Linear Accelerator Laboratory Stanford Linear Accelerator Laboratory Advanced Light Source at LBL Advanced Light Source at LBL The conference will be organised in the heart of beautiful San Francisco. The program will consist of invited and contributed lectures divided in sessions on the use of synchrotron SAXS/WAXD, imaging and tomography, soft x-rays, x-ray spectroscopy, GISAXS and reflectivity, micro-beams and hyphenated techniques in polymer science. Poster contributions are more than welcome and will be highlighted during the poster sessions. Visits to both SLAC as well as LBL will be organised. San Francisco can easily be reached. It is served by two major international airports San Francisco International Airport and Oakland International Airport. Both are being served by most major airlines with easy connections to Europe and Asia as well as national destinations. Both also boast excellent connections to San Francisco city centre. We are looking forward to seeing you in the vibrant city by the Bay in September 2012. Golden gate bridge Alexander Hexemer Lawrence Berkeley National Laboratory, Advanced Light Source, Berkeley, CA 94720, USA Michael F Toney Stanford Synchrotron Radiation Lightsource, Menlo Pk, CA 94025, USA E-mail: ahexemer@lbl.gov, mftoney@slac.stanford.edu

  13. Designing PDT-based combinations to overcome chemoresistance in heterocellular 3D tumor models (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Rizvi, Imran; Briars, Emma A.; Bulin, Anne-Laure; Anbil, Sriram; Vecchio, Daniela; Alkhateeb, Ahmed; Hanna, William R.; Celli, Jonathan P.; Hasan, Tayyaba

    2016-03-01

    A major barrier to treating advanced-stage cancers is heterogeneity in the responsiveness of metastatic disease to conventional therapies leading to resistance and treatment failure. Photodynamic therapy (PDT) has been shown to synergize with conventional agents and to overcome the evasion pathways that cause resistance. Developing PDT-based combinations that target resistant tumor populations and cooperate mechanistically with conventional agents is an increasingly promising approach to improve therapeutic efficacy while minimizing toxicity, particularly in complex disease sites. Identifying the molecular, cellular, and microenvironmental cues that lead to heterogeneity and treatment resistance is critical to developing strategies to target unresponsive regions of stubborn disease. Cell-based research platforms that integrate key microenvironmental cues are emerging as increasingly important tools to improve the translational efficiency of new agents, and to design combination regimens. Among the challenges associated with developing and scaling complex cell-based screening platforms is the need to integrate, and balance, biological relevance with appropriate, high-content imaging routines that provide meaningful quantitative readouts of therapeutic response. The benefits and challenges associated with deriving meaningful insights from complex cell-based models will be presented, with a particular emphasis on overcoming chemoresistance mediated by physical stress and communication with stromal partners (e.g. tumor endothelial cells, which are emerging as dynamic regulators of treatment resistance) using PDT-based combinations.

  14. In vivo perfusion assessment of an anastomosis surgery on porcine intestinal model (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Le, Hanh N. D.; Opferman, Justin; Decker, Ryan; Cheon, Gyeong W.; Kim, Peter C. W.; Kang, Jin U.; Krieger, Axel

    2016-04-01

    Anastomosis, the connection of two structures, is a critical procedure for reconstructive surgery with over 1 million cases/year for visceral indication alone. However, complication rates such as strictures and leakage affect up to 19% of cases for colorectal anastomoses and up to 30% for visceral transplantation anastomoses. Local ischemia plays a critical role in anastomotic complications, making blood perfusion an important indicator for tissue health and predictor for healing following anastomosis. In this work, we apply a real time multispectral imaging technique to monitor impact on tissue perfusion due to varying interrupted suture spacing and suture tensions. Multispectral tissue images at 470, 540, 560, 580, 670 and 760 nm are analyzed in conjunction with an empirical model based on diffuse reflectance process to quantify the hemoglobin oxygen saturation within the suture site. The investigated tissues for anastomoses include porcine small (jejunum and ileum) and large (transverse colon) intestines. Two experiments using interrupted suturing with suture spacing of 1, 2, and 3 mm and tension levels from 0 N to 2.5 N are conducted. Tissue perfusion at 5, 10, 20 and 30 min after suturing are recorded and compared with the initial normal state. The result indicates the contrast between healthy and ischemic tissue areas and assists the determination of suturing spacing and tension. Therefore, the assessment of tissue perfusion will permit the development and intra-surgical monitoring of an optimal suture protocol during anastomosis with less complications and improved functional outcome.

  15. Visualization of microhemorrhages with optical histology in mouse model of cerebral amyloid angiopathy (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Lo, Patrick; Crouzet, Christian; Vasilevko, Vitaly; Choi, Bernard

    2016-03-01

    Cerebral amyloid angiopathy (CAA) is a neurovascular disease that is strongly associated with an increase in the number and size of spontaneous microhemorrhages. Conventional methods, such as magnetic resonance imaging (MRI), can detect microhemorrhages while positron emission tomography (PET) with Pittsburgh Compound B can detect amyloid deposits. MRI and PET can separately demonstrate the presence of microhemorrhages and CAA in affected brains in vivo; however, there is still a lack of strong evidence for the direct involvement of CAA in the presence of microhemorrhage formation. In this study, we use optical histology, a method which combines histochemical staining, chemical optical clearing, and optical imaging, in a Tg2576 mouse model of Alzheimer's disease to enable simultaneous, co-registered three-dimensional visualization of cerebral microvasculature, microhemorrhages, and amyloid deposits. Our data strongly suggest that microhemorrhages are localized within the brain regions affected by amyloid deposits. All but two observed microhemorrhages (n=18) were closely localized with vessels affected by CAA whereas no microhemorrhages or amyloid deposits were observed in wild type mouse brain sections. Our data also suggest that the predominant type of CAA-related microhemorrhage is associated with leaky or ruptured hemorrhagic microvasculature within the hippocampus and cerebral cortex rather than occluded ischemic microvasculature. The proposed optical histology method will allow future studies about the relationship between CAA and microhemorrhages during disease development and in response to treatment strategies.

  16. Conditions for NIR fluorescence-guided tumor resectioning in preclinical lung cancer model (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Kim, Minji; Quan, Yuhua; Choi, Byeong Hyun; Choi, Yeonho; Kim, Hyun Koo; Kim, Beop-Min

    2016-03-01

    Pulmonary nodule could be identified by intraoperative fluorescence imaging system from systemic injection of indocyanine green (ICG) which achieves enhanced permeability and retention (EPR) effects. This study was performed to evaluate optimal injection time of ICG for detecting cancer during surgery in rabbit lung cancer model. VX2 carcinoma cell was injected in rabbit lung under fluoroscopic computed tomography-guidance. Solitary lung cancer was confirmed on positron emitting tomography with CT (PET/CT) 2 weeks after inoculation. ICG was administered intravenously and fluorescent intensity of lung tumor was measured using the custom-built intraoperative color and fluorescence merged imaging system (ICFIS) for 15 hours. Solitary lung cancer was resected through thoracoscopic version of ICFIS. ICG was observed in all animals. Because Lung has fast blood pulmonary circulation, Fluorescent signal showed maximum intensity earlier than previous studies in other organs. Fluorescent intensity showed maximum intensity within 6-9 hours in rabbit lung cancer. Overall, Fluorescent intensity decreased with increasing time, however, all tumors were detectable using fluorescent images until 12 hours. In conclusion, while there had been studies in other organs showed that optimal injection time was at least 24 hours before operation, this study showed shorter optimal injection time at lung cancer. Since fluorescent signal showed the maximum intensity within 6-9 hours, cancer resection could be performed during this time. This data informed us that optimal injection time of ICG should be evaluated in each different solid organ tumor for fluorescent image guided surgery.

  17. Optical coherence tomography noise modeling and fundamental bounds on human retinal layer segmentation accuracy (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    DuBose, Theodore B.; Milanfar, Peyman; Izatt, Joseph A.; Farsiu, Sina

    2016-03-01

    The human retina is composed of several layers, visible by in vivo optical coherence tomography (OCT) imaging. To enhance diagnostics of retinal diseases, several algorithms have been developed to automatically segment one or more of the boundaries of these layers. OCT images are corrupted by noise, which is frequently the result of the detector noise and speckle, a type of coherent noise resulting from the presence of several scatterers in each voxel. However, it is unknown what the empirical distribution of noise in each layer of the retina is, and how the magnitude and distribution of the noise affects the lower bounds of segmentation accuracy. Five healthy volunteers were imaged using a spectral domain OCT probe from Bioptigen, Inc, centered at 850nm with 4.6µm full width at half maximum axial resolution. Each volume was segmented by expert manual graders into nine layers. The histograms of intensities in each layer were then fit to seven possible noise distributions from the literature on speckle and image processing. Using these empirical noise distributions and empirical estimates of the intensity of each layer, the Cramer-Rao lower bound (CRLB), a measure of the variance of an estimator, was calculated for each boundary layer. Additionally, the optimum bias of a segmentation algorithm was calculated, and a corresponding biased CRLB was calculated, which represents the improved performance an algorithm can achieve by using prior knowledge, such as the smoothness and continuity of layer boundaries. Our general mathematical model can be easily adapted for virtually any OCT modality.

  18. Mechanical modeling of cholesterol crystallization in atherosclerotic plaques base on Micro-OCT images (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Luo, Yuemei; Liu, Xinyu; Chen, Si; Cui, Dongyao; Wang, Xianghong; Liu, Linbo

    2016-02-01

    Plaque rupture is the critical cause of cardiovascular thrombosis but this process is still under discussion. Recent studies show that, during crystallization, cholesterol crystals in atheromatous plaques accumulate rapidly in a limited space and may result in plaque rupture. However, the actual role of cholesterol crystals on plaque rupture remains unclear due to the lack of detailed morphological information of cholesterol crystals. In this study, we used a Micro-optical coherence tomography (µOCT) setup with 1-2 µm spatial resolution to extract the geometry of cholesterol crystals from human atherosclerotic artery ex vivo firstly. With measured dimensions of cholesterol crystals by this µOCT system (the average length and thickness of 269.1±80.16 µm and 3.0±0.33 µm), we developed a two-dimensional mechanical model in which rectangular shaped cholesterol crystals distribute at different locations spatially. We predicted the stress on the thin cap induced by the expansion of cholesterol crystals by use of finite-element method. Since a large portion of plaques (58%) rupture at points of peak circumferential stress (PCS), we used PCS as the primary indicator of plaque stability with blood pressure of 14.6 kPa on the lumen. The results demonstrate that loading of the concentrated crystals especially at the cap shoulder destabilize the plaque by proportionally increasing the PCS, while evenly distributed crystals loading along the cap might impose less PCS to the plaque than the concentrated case.

  19. Conference Summary

    NASA Astrophysics Data System (ADS)

    Ellis, R. S.

    2008-10-01

    This first Subaru international conference has highlighted the remarkably diverse and significant contributions made using the 8.2m Subaru telescope by both Japanese astronomers and the international community. As such, it serves as a satisfying tribute to the pioneering efforts of Professors Keiichi Kodaira and Sadanori Okamura whose insight and dedication is richly rewarded. Here I try to summarize the recent impact of wide field science in extragalactic astronomy and cosmology and take a look forward to the key questions we will address in the near future.

  20. Conferences revisited

    NASA Astrophysics Data System (ADS)

    Radcliffe, Jonathan

    2008-08-01

    Way back in the mid-1990s, as a young PhD student, I wrote a Lateral Thoughts article about my first experience of an academic conference (Physics World 1994 October p80). It was a peach of a trip - most of the lab decamped to Grenoble for a week of great weather, beautiful scenery and, of course, the physics. A whole new community was there for me to see in action, and the internationality of it all helped us to forget about England's non-appearance in the 1994 World Cup finals.

  1. Sphingosine Kinase 1 Deficiency Confers Protection against Hyperoxia-Induced Bronchopulmonary Dysplasia in a Murine Model

    PubMed Central

    Harijith, Anantha; Pendyala, Srikanth; Reddy, Narsa M.; Bai, Tao; Usatyuk, Peter V.; Berdyshev, Evgeny; Gorshkova, Irina; Huang, Long Shuang; Mohan, Vijay; Garzon, Steve; Kanteti, Prasad; Reddy, Sekhar P.; Raj, J. Usha; Natarajan, Viswanathan

    2014-01-01

    Bronchopulmonary dysplasia of the premature newborn is characterized by lung injury, resulting in alveolar simplification and reduced pulmonary function. Exposure of neonatal mice to hyperoxia enhanced sphingosine-1-phosphate (S1P) levels in lung tissues; however, the role of increased S1P in the pathobiological characteristics of bronchopulmonary dysplasia has not been investigated. We hypothesized that an altered S1P signaling axis, in part, is responsible for neonatal lung injury leading to bronchopulmonary dysplasia. To validate this hypothesis, newborn wild-type, sphingosine kinase1−/− (Sphk1−/−), sphingosine kinase 2−/− (Sphk2−/−), and S1P lyase+/− (Sgpl1+/−) mice were exposed to hyperoxia (75%) from postnatal day 1 to 7. Sphk1−/−, but not Sphk2−/− or Sgpl1+/−, mice offered protection against hyperoxia-induced lung injury, with improved alveolarization and alveolar integrity compared with wild type. Furthermore, SphK1 deficiency attenuated hyperoxia-induced accumulation of IL-6 in bronchoalveolar lavage fluids and NADPH oxidase (NOX) 2 and NOX4 protein expression in lung tissue. In vitro experiments using human lung microvascular endothelial cells showed that exogenous S1P stimulated intracellular reactive oxygen species (ROS) generation, whereas SphK1 siRNA, or inhibitor against SphK1, attenuated hyperoxia-induced S1P generation. Knockdown of NOX2 and NOX4, using specific siRNA, reduced both basal and S1P-induced ROS formation. These results suggest an important role for SphK1-mediated S1P signaling–regulated ROS in the development of hyperoxia-induced lung injury in a murine neonatal model of bronchopulmonary dysplasia. PMID:23933064

  2. DOE Zero Energy Ready Home Case Study: Cobblestone Homes — 2014 Model Home, Midland, MI

    SciTech Connect

    none,

    2014-09-01

    This builder's first DOE Zero Energy Ready Home won a Custom Builder award in the 2014 Housing Innovation Awards, scored HERS 49 without PV or HERS 44 with 1.4 kW of PV, and served as a prototype and energy efficiency demonstration model while performance testing was conducted.

  3. Critique of "Where Does Creativity Fit into a Productivist Industrial Model of Knowledge Production?"

    ERIC Educational Resources Information Center

    Harris, Carole Ruth

    2010-01-01

    This article presents the author's comments on Hisham Ghassib's article entitled "Where Does Creativity Fit into a Productivist Industrial Model of Knowledge Production?" In his article, Ghassib (2010) provides an overview of the philosophical foundations that led to exact science, its role in what was later to become a driving force in the modern…

  4. Comments on Ghassib's "Where Does Creativity Fit into a Productivist Industrial Model of Knowledge Production?"

    ERIC Educational Resources Information Center

    McCluskey, Ken W.

    2010-01-01

    This article presents the author's comments on Hisham B. Ghassib's "Where Does Creativity Fit into a Productivist Industrial Model of Knowledge Production?" Ghassib's article focuses on the transformation of science from pre-modern times to the present. Ghassib (2010) notes that, unlike in an earlier era when the economy depended on static…

  5. Review of Hisham Ghassib: Where Does Creativity Fit into the Productivist Industrial Model of Knowledge Production?

    ERIC Educational Resources Information Center

    Neber, Heinz

    2010-01-01

    In this article, the author presents his comments on Hisham Ghassib's article entitled "Where Does Creativity Fit into the Productivist Industrial Model of Knowledge Production?" Ghassib (2010) describes historical transformations of science from a marginal and non-autonomous activity which had been constrained by traditions to a self-autonomous,…

  6. Translating Research from Animal Models: Does It Matter that Our Rodents are So Cold?

    EPA Science Inventory

    Does it matter that preclinical rodent models are routinely housed below their thermoneutral zone and are thereby cold-stressed? We compile evidence showing that rodents housed below their thermoneutral zone are cold-stressed, hypermetalbolic, hypertensive, sleep-deprived, obesi...

  7. Geothermal Electricity Technologies Evaluation Model DOE Tool for Assessing Impact of Research on Cost of Power

    SciTech Connect

    Greg Mines

    2008-01-01

    The U.S. Department of Energy (DOE) has developed a spreadsheet model to provide insight as to how its research activities can impact of cost of producing power from geothermal energy. This model is referred to as GETEM, which stands for “Geothermal Electricity Technologies Evaluation Model”. Based on user input, the model develops estimates of costs associated with exploration, well field development, and power plant construction that are used along with estimated operating costs to provide a predicted power generation cost. The model allows the user to evaluate how reductions in cost, or increases in performance or productivity will impact the predicted power generation cost. This feature provides a means of determining how specific technology improvements can impact generation costs, and as such assists DOE in both prioritizing research areas and identifying where research is needed.

  8. Mechanics of Textile Composites Conference

    SciTech Connect

    Poe, C.C. Jr.; Harris, C.E.

    1995-10-01

    This document is a compilation of papers presented at the Mechanics of Textile Composites Conference in Hampton, Virginia, December 6-8, 1994. This conference was the culmination of a 3-year program that was initiated by NASA late in 1990 to develop mechanics of textile composites in support of the NASA Advanced Composites Technology Program (ACT). The goal of the program was to develop mathematical models of textile preform materials and test methods to facilitate structural analysis and design. Participants in the program were from NASA, academia, and industry. Separate abstracts have been submitted to the database for articles from this conference.

  9. Hot isostatic pressing: Conference proceedings

    SciTech Connect

    Froes, F.H.; Hebeisen, J.; Widmer, R.

    1996-12-31

    The International Conference on Hot Isostatic Pressing was held on May 20-22, 1996, in Andover, Massachusetts. This conference discussed the state-of-the-art of hot isostatic pressing (HIP) and competing compaction techniques. HIP allows complex cost-effective near net shapes to be produced from powder products, densification of castings thereby enhancing performance, retention of metastable structures such as nano-sized grains, and even creative food processing. Sections in the conference covered such items as fundamentals, mathematical modeling, equipment and instrumentation, advanced materials and processes, composite materials, casting densification, surface treatments, HIP bonding, and competing technologies. Forty five papers were processed separately for inclusion on the data base.

  10. Mississippi Climate & Hydrology Conference

    SciTech Connect

    Lawford, R.; Huang, J.

    2002-05-01

    The GEWEX Continental International Project (GCIP), which started in 1995 and completed in 2001, held its grand finale conference in New Orleans, LA in May 2002. Participants at this conference along with the scientists funded through the GCIP program are invited to contribute a paper to a special issue of Journal of Geophysical Research (JGR). This special JGR issue (called GCIP3) will serve as the final report on scientific research conducted by GCIP investigators. Papers are solicited on the following topical areas, but are not limited to, (1) water energy budget studies; (2) warm season precipitation; (3) predictability and prediction system; (4) coupled land-atmosphere models; (5) climate and water resources applications. The research areas cover observations, modeling, process studies and water resources applications.

  11. Workforce Transition Model for DOE-AL non-nuclear reconfiguration

    SciTech Connect

    Stahlman, E.J.; Lewis, R.E.

    1993-10-01

    The Pacific Northwest Laboratory (PNL) was tasked by the US Department of Energy Albuquerque Field Office (DOE-AL) to develop a workforce assessment and transition planning tool to support integrated decision making at a single DOE installation. The planning tool permits coordinated, integrated workforce planning to manage growth, decline, or transition within a DOE installation. The tool enhances the links and provides commonality between strategic, programmatic, and operations planners and human resources. Successful development and subsequent complex-wide implementation of the model will also facilitate planning at the national level by enforcing a consistent format on data that are now collected by installations in corporate-specific formats that are not amenable to national-level analyses. The workforce assessment and transition planning tool consists of two components: the Workforce Transition Model and the Workforce Budget Constraint Model. The Workforce Transition Model, the preponderant of the two, assists decision makers to identify and evaluates alternatives for transitioning the current workforce to meet the skills required to support projected workforce requirements. The Workforce Budget Constraint Model helps estimate the number of personnel that will be affected given a workforce budget increase or decrease and assists in identifying how the corresponding hiring or layoffs should be distributed across the common occupational classification system (COCS) occupations. The conceptual models and the computer implementation are described.

  12. Conference of University Administrators Conference Proceedings (12th, Surrey, England, March 21-23, 1985).

    ERIC Educational Resources Information Center

    Conference of Univ. Administrators.

    Conference proceedings for the Conference of University Administrators include summaries of conference sessions, along with Austin Pearce's paper, "The Needs of Industry: What Are They?" Sessions focused on: forming a university company, financial diversification, financial modeling, stock exchange investment and universities, funding of research,…

  13. Family Resource Systems: The Nebraska Model. Proceedings of the Family Resource Systems Conference (January 24-25, 1980).

    ERIC Educational Resources Information Center

    Stark, Jack A., Ed.

    Proceedings are presented from a 1980 conference on community based services for families of developmentaly disabled children. The following ten papers are included: "Leading Edge Services to Families of Persons with Developmental Disabilities" (R. Perske); "Family Resource Services and Support Systems for Families with Handicapped Children" (B.…

  14. Modeling extracellular matrix (ECM) alterations in ovarian cancer by multiphoton excited fabrication of stromal models (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Campagnola, Paul J.; Ajeti, Visar; Lara, Jorge; Eliceiri, Kevin W.; Patankar, Mansh

    2016-04-01

    A profound remodeling of the extracellular matrix (ECM) occurs in human ovarian cancer but it unknown how this affects tumor growth, where this understanding could lead to better diagnostics and therapeutic approaches. We investigate the role of these ECM alterations by using multiphoton excited (MPE) polymerization to fabricate biomimetic models to investigate operative cell-matrix interactions in invasion/metastasis. First, we create nano/microstructured gradients mimicking the basal lamina to study adhesion/migration dynamics of ovarian cancer cells of differing metastatic potential. We find a strong haptotactic response that depends on both contact guidance and ECM binding cues. While we found enhanced migration for more invasive cells, the specifics of alignment and directed migration also depend on cell polarity. We further use MPE fabrication to create collagen scaffolds with complex, 3D submicron morphology. The stromal scaffold designs are derived directly from "blueprints" based on SHG images of normal, high risk, and malignant ovarian tissues. The models are seeded with different cancer cell lines and this allows decoupling of the roles of cell characteristics (metastatic potential) and ECM structure and composition (normal vs cancer) on adhesion/migration dynamics. We found the malignant stroma structure promotes enhanced migration and proliferation and also cytoskeletal alignment. Creating synthetic models based on fibers patterns further allows decoupling the topographic roles of the fibers themselves vs their alignment within the tissue. These models cannot be synthesized by other conventional fabrication methods and we suggest the MPE image-based fabrication method will enable a variety of studies in cancer biology.

  15. Common challenges for ecological modelling: Synthesis of facilitated discussions held at the symposia organized for the 2009 conference of the International Society for Ecological Modelling in Quebec City, Canada

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The eleven symposia organized for the 2009 conference of the International Society for Ecological Modelling (ISEM 2009) held in Quebec City, Canada, October 6-9, 2009, included facilitated discussion sessions following formal presentations. Each symposium focused on a specific subject, and all the s...

  16. Operations managers conference: summary of proceedings

    SciTech Connect

    None,

    1982-02-01

    The Association for Energy Systems, Operations, and Programming (AESOP) was created to provide Department of Energy (DOE) and DOE-contractor management personnel with a means for acquiring and exchanging information concerning effective management of ADP resources and personnel as well as a variety of computer applications. AESOP serves as a forum for the data processing management of more than 50 DOE offices and private corporations under contract to DOE. AESOP Operations Managers Conferences are held approximately every 18 months. Conference topics include personnel problems, training situations, reorganization plans, and work scheduling. Security and other issues affecting ADP procedures and personnel are also often addressed. Papers published in this volume of the proceedings have been summarized from speeches and discussions that were presented at the seventh AESOP Operations Managers Conference.

  17. 2004 Mutagenesis Gordon Conference

    SciTech Connect

    Dr. Sue Jinks-Robertson

    2005-09-16

    Mutations are genetic alterations that drive biological evolution and cause many, if not all, human diseases. Mutation originates via two distinct mechanisms: ''vertical'' variation is de novo change of one or few bases, whereas ''horizontal'' variation occurs by genetic recombination, which creates new mosaics of pre-existing sequences. The Mutagenesis Conference has traditionally focused on the generation of mutagenic intermediates during normal DNA synthesis or in response to environmental insults, as well as the diverse repair mechanisms that prevent the fixation of such intermediates as permanent mutations. While the 2004 Conference will continue to focus on the molecular mechanisms of mutagenesis, there will be increased emphasis on the biological consequences of mutations, both in terms of evolutionary processes and in terms of human disease. The meeting will open with two historical accounts of mutation research that recapitulate the intellectual framework of this field and thereby place the current research paradigms into perspective. The two introductory keynote lectures will be followed by sessions on: (1) mutagenic systems, (2) hypermutable sequences, (3) mechanisms of mutation, (4) mutation avoidance systems, (5) mutation in human hereditary and infectious diseases, (6) mutation rates in evolution and genotype-phenotype relationships, (7) ecology, mutagenesis and the modeling of evolution and (8) genetic diversity of the human population and models for human mutagenesis. The Conference will end with a synthesis of the meeting as the keynote closing lecture.

  18. 34 CFR 426.22 - What selection criteria does the Secretary use for the Program for Model Consumer and Homemaking...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What selection criteria does the Secretary use for the... selection criteria does the Secretary use for the Program for Model Consumer and Homemaking Education Projects? (a) The Secretary uses the following criteria to evaluate an application for a model consumer...

  19. Conference summary

    NASA Astrophysics Data System (ADS)

    Rebolo, R.

    ``Brown dwarfs come of age" was a stimulating conference attended by a large number of very active researchers, including many young students and post-docs who were largely responsible for the lively atmosphere that we enjoyed during the full meeting. Major theoretical and observational challenges currently faced in the study of brown dwarfs were reviewed. Key spectroscopic work is being conducted to determine atmospheric temperatures, surface gravities and metallicities, essential to understand the evolution of substellar objects. Research on ultracool atmospheres is extended down to temperatures typical of the atmosphere of the Earth. Characterisation of brown dwarfs at all wavelengths from X-ray to radio is ongoing and investigation of time domain phenomena reveal interesting new processes in cool atmospheres. In addition to talks on these topics, a large number of presentations addressed the formation and evolution of brown dwarfs, the lower end of the Initial Mass Function, the properties of substellar binaries, the angular momentum and disk evolution in very low-mass systems, results of large scale surveys aimed to find the lowest luminosity and coolest brown dwarfs, searches in star clusters delineating the evolution with age of the properties of brown dwarfs, binary searches and subsequent follow-up work enabling dynamical mass determinations. The excellent level of the review talks, oral and poster presentations and the work of the enthusiastic researchers that attended the meeting ensure a brilliant future for substellar research 18 years after the discovery of the first brown dwarfs.

  20. Translating animal model research: does it matter that our rodents are cold?

    PubMed

    Maloney, Shane K; Fuller, Andrea; Mitchell, Duncan; Gordon, Christopher; Overton, J Michael

    2014-11-01

    Does it matter that rodents used as preclinical models of human biology are routinely housed below their thermoneutral zone? We compile evidence showing that such rodents are cold-stressed, hypermetabolic, hypertensive, sleep-deprived, obesity-resistant, fever-resistant, aging-resistant, and tumor-prone compared with mice housed at thermoneutrality. The same genotype of mouse has a very different phenotype and response to physiological or pharmacological intervention when raised below or at thermoneutrality. PMID:25362635

  1. Networks Technology Conference

    NASA Technical Reports Server (NTRS)

    Tasaki, Keiji K. (Editor)

    1993-01-01

    The papers included in these proceedings represent the most interesting and current topics being pursued by personnel at GSFC's Networks Division and supporting contractors involved in Space, Ground, and Deep Space Network (DSN) technical work. Although 29 papers are represented in the proceedings, only 12 were presented at the conference because of space and time limitations. The proceedings are organized according to five principal technical areas of interest to the Networks Division: Project Management; Network Operations; Network Control, Scheduling, and Monitoring; Modeling and Simulation; and Telecommunications Engineering.

  2. DOE Wind Program Update: June 4, 2006;

    SciTech Connect

    Not Available

    2006-06-01

    The DOE Wind Program Update provides WindPower Conference attendees with information about recent DOE events, including Assistant Secretary Karsner, a wind turbine blade test facility CRADA, and 2005 Wind Energy Award recipients.

  3. Construction and analysis of a Vibrio cholerae delta-aminolevulinic acid auxotroph which confers protective immunity in a rabbit model.

    PubMed Central

    Rijpkema, S G; Bik, E M; Jansen, W H; Gielen, H; Versluis, L F; Stouthamer, A H; Guinée, P A; Mooi, F R

    1992-01-01

    Vibrio cholerae CVD101 is a very effective live vaccine. Although this strain does not produce active cholera toxin because of a mutation in the gene for the cholera toxin A subunit, it still shows residual pathogenicity. To attenuate CVD101 further, we set out to isolate derivatives of CVD101 which were limited in their ability to proliferate in vivo. Two delta-aminolevulinic acid auxotrophs of CVD101, designated V286 and V287, were isolated by transposon mutagenesis and penicillin enrichment. Southern blotting revealed that the mutants differed with respect to the location of the transposon insertion. Under aerobic conditions, in the absence of delta-aminolevulinic acid, both mutants showed diminished growth compared with CVD101. The growth of V286 was most severely affected. Microaerophilic growth of both mutants was less affected. Competition experiments with a rabbit model showed that strain V286 was found in numbers 10(3)- to 10(4)-fold lower than its parental strain. This observation indicates that strain V286 is impaired in its ability to colonize the rabbit intestine. It also supports an important role for aerobic growth in the colonization of the intestine by V. cholerae. Vaccination of rabbits with a single dose of strain V286 resulted in full protection against challenge with a virulent strain. Strain V286 was not shed from rabbits in a cultivatable form. Our results suggest that delta-aminolevulinic acid auxotrophy can attenuate V. cholerae by limiting its ability to colonize without affecting its capacity to induce protective immunity. Furthermore, this type of mutation may prevent the spread of V. cholerae vaccine strains in the environment. Images PMID:1587587

  4. Phosphorus and soil development: does the Walker and Syers model apply to semiarid ecosystems?

    PubMed

    Selmants, Paul C; Hart, Stephen C

    2010-02-01

    The Walker and Syers model of phosphorus (P) transformations during pedogenesis is widely accepted for the development of humid ecosystems, but long-term P dynamics of more arid ecosystems remain poorly understood. We tested the Walker and Syers model in semiarid piñon-juniper woodlands by measuring soil P fractions under tree canopies and in intercanopy spaces along a well-constrained, approximately 3000 ka (1 ka = 1000 years) volcanic substrate age gradient in northern Arizona, USA. The various pools of soil P behaved largely as predicted; total soil P and primary mineral P declined consistently with substrate age, labile inorganic P increased early in soil development and then declined at later stages, and organic phosphorus increased consistently across the chronosequence. Within each site, soils under tree canopies tended to have higher concentrations of labile and intermediately available P fractions compared to intercanopy soils. However, the degree of spatial heterogeneity conferred by tree islands was moderated by the stage of soil development. In contrast, tree islands had no influence on within-site distribution of more recalcitrant soil P pools, which appear to be controlled solely by the stage of pedogenesis. Coincident with declines in total P, primary mineral P, and labile inorganic P, we found that phosphatase enzyme activity increased with substrate age; a result consistent with greater ecosystem-level P demand on older, more highly weathered substrates. Our results suggest that, compared to humid climates, reduced inputs of water, energy, and acidity to semiarid ecosystems slow the rate of change in P fractions during pedogenesis, but the overall pattern remains consistent with the Walker and Syers model. Furthermore, our data imply that pedogenic change may be an important factor controlling the spatial distribution of labile P pools in semiarid ecosystems. Taken together, these data should both broaden and unify terrestrial ecosystem

  5. Regression Mixture Models: Does Modeling the Covariance Between Independent Variables and Latent Classes Improve the Results?

    PubMed

    Lamont, Andrea E; Vermunt, Jeroen K; Van Horn, M Lee

    2016-01-01

    Regression mixture models are increasingly used as an exploratory approach to identify heterogeneity in the effects of a predictor on an outcome. In this simulation study, we tested the effects of violating an implicit assumption often made in these models; that is, independent variables in the model are not directly related to latent classes. Results indicate that the major risk of failing to model the relationship between predictor and latent class was an increase in the probability of selecting additional latent classes and biased class proportions. In addition, we tested whether regression mixture models can detect a piecewise relationship between a predictor and outcome. Results suggest that these models are able to detect piecewise relations but only when the relationship between the latent class and the predictor is included in model estimation. We illustrate the implications of making this assumption through a reanalysis of applied data examining heterogeneity in the effects of family resources on academic achievement. We compare previous results (which assumed no relation between independent variables and latent class) to the model where this assumption is lifted. Implications and analytic suggestions for conducting regression mixture based on these findings are noted.

  6. PREFACE: Wake Conference 2015

    NASA Astrophysics Data System (ADS)

    Barney, Andrew; Nørkær Sørensen, Jens; Ivanell, Stefan

    2015-06-01

    at scientists and PhD students working in the field of wake dynamics. The conference covers the following subject areas: Wake and vortex dynamics, instabilities in trailing vortices and wakes, simulation and measurements of wakes, analytical approaches for modeling wakes, wake interaction and other wind farm investigations. Many people have been involved in producing the 2015 Wake Conference proceedings. The work by the more than 60 reviewers ensuring the quality of the papers is greatly appreciated. The timely evaluation and coordination of the reviews would not have been possible without the work of the section editors: Christian Masson, ÉTS, Fernando Porté-Agel, EPFL, Gerard Schepers, ECN Wind Energy, Gijs Van Kuik, Delft University, Gunner Larsen, DTU Wind Energy, Jakob Mann, DTU Wind Energy, Javier Sanz Rodrigo, CENER, Johan Meyers, KU Leuven, Rebecca Barthelmie, Cornell University, Sandrine Aubrun-Sanches, Université d'Orléans and Thomas Leweke, IRPHE-CNRS. We are also immensely indebted to the very responsive support from the editorial team at IOP Publishing, especially Sarah Toms, during the review process of these proceedings. Visby, Sweden, June 2015 Andrew Barney, Jens Nørkær Sørensen and Stefan Ivanell Uppsala University - Campus Gotland

  7. Final Report 10th Conference on the Intersections of Particle and Nuclear Physics

    SciTech Connect

    Marshak, Marvin L.

    2013-11-03

    The 10th Conference on the Intersections of Particle and Nuclear Physics was held in LaJolla, California on May 26 to May 31, 2009. The Conference Proceedings are published by the American Institute of Physics in Volume 1182 of the AIP Conference Proceedings (ISBN: 978-0-7354-0723-7). The Proceedings include papers from each of the Conference Presenters and a detailed schedule of talks at the Conference. The Table of Contents of the Conference Proceedings is available at http://scitation.aip.org/content/aip/proceeding/aipcp/1182. Support by the U.S. Department of Energy and by DOE Laboratories was essential to the success of the Conference.

  8. Does model structure limit the use of satellite data as hydrologic forcing for distributed operational models?

    NASA Astrophysics Data System (ADS)

    Bowman, A. L.; Franz, K.; Hogue, T. S.

    2015-12-01

    We are investigating the implications for use of satellite data in operational streamflow prediction. Specifically, the consequence of potential hydrologic model structure deficiencies on the ability to achieve improved forecast accuracy through the use of satellite data. We want to understand why advanced data do not lead to improved streamflow simulations by exploring how various fluxes and states differ among models of increasing complexity. In a series of prior studies, we investigated the use of a daily satellite-derived potential evapotranspiration (PET) estimate as input to the National Weather Service (NWS) streamflow forecast models for watersheds in the Upper Mississippi and Red river basins. Although the spatial PET product appears to represent the day-to-day variability in PET more realistically than current climatological methods used by the NWS, the impact of the satellite data on streamflow simulations results in slightly poorer model efficiency overall. Analysis of the model states indicates the model progresses differently between simulations with baseline PET and the satellite-derived PET input, though variation in streamflow simulations overall is negligible. For instance, the upper zone states, responsible for the high flows of a hydrograph, show a profound difference, while simulation of the peak flows tend to show little variation in the timing and magnitude. Using the spatial PET input, the lower zone states show improvement with simulating the recession limb and baseflow portion of the hydrograph. We anticipate that through a better understanding of the relationship between model structure, model states, and simulated streamflow we will be able to diagnose why simulations of discharge from the forecast model have failed to improve when provided seemingly more representative input data. Identifying model limitations are critical to demonstrating the full benefit of a satellite data for operational use.

  9. Development of numerical models for injury biomechanics research: a review of 50 years of publications in the Stapp Car Crash Conference.

    PubMed

    Yang, King H; Hu, Jingwen; White, Nicholas A; King, Albert I; Chou, Clifford C; Prasad, Priya

    2006-11-01

    Numerical analyses frequently accompany experimental investigations that study injury biomechanics and improvements in automotive safety. Limited by computational speed, earlier mathematical models tended to simplify the system under study so that a set of differential equations could be written and solved. Advances in computing technology and analysis software have enabled the development of many sophisticated models that have the potential to provide a more comprehensive understanding of human impact response, injury mechanisms, and tolerance. In this article, 50 years of publications on numerical modeling published in the Stapp Car Crash Conference Proceedings and Journal were reviewed. These models were based on: (a) author-developed equations and software, (b) public and commercially available programs to solve rigid body dynamic models (such as MVMA2D, CAL3D or ATB, and MADYMO), and (c) finite element models. A clear trend that can be observed is the increasing use of the finite element method for model development. A review of these modeling papers clearly indicates the progression of the state-of-the-art in computational methods and technologies in injury biomechanics. PMID:17311173

  10. The protoxin Cry1Ac of Bacillus thuringiensis improves the protection conferred by intranasal immunization with Brucella abortus RB51 in a mouse model.

    PubMed

    González-González, Edith; García-Hernández, Ana Lilia; Flores-Mejía, Raúl; López-Santiago, Rubén; Moreno-Fierros, Leticia

    2015-02-25

    Brucellosis is a zoonotic disease affecting many people and animals worldwide. Preventing this infection requires improving vaccination strategies. The protoxin Cry1Ac of Bacillus thuringiensis is an adjuvant that, in addition to increasing the immunogenicity of different antigens, has shown to be protective in different models of parasitic infections. The objective of the present study was to test whether the intranasal co-administration of pCry1Ac with the RB51 vaccine strain of Brucella abortus confers protection against an intranasal challenge with the virulent strain B. abortus 2308 in BALB/c mice. The results showed that co-administration of pCry1Ac and RB51, increased the immunoprotection conferred by the vaccine as evidenced by the following: (1) decrease of the splenic bacterial load when challenged intranasally with the virulent strain; (2) greater in vivo cytotoxic activity in response to the transference of previously infected cells; (3) further proliferation of cytotoxic TCD8+ cells in response to stimulation with heat-inactivated bacteria; (4) increased production of TNF-α and IFN-γ; and (5) significant IgG2a response. These results indicate that the use of the Cry1Ac protein as a mucosal adjuvant via the intranasal route can be a promising alternative for improving current RB51 vaccine against brucellosis. PMID:25497237

  11. The protoxin Cry1Ac of Bacillus thuringiensis improves the protection conferred by intranasal immunization with Brucella abortus RB51 in a mouse model.

    PubMed

    González-González, Edith; García-Hernández, Ana Lilia; Flores-Mejía, Raúl; López-Santiago, Rubén; Moreno-Fierros, Leticia

    2015-02-25

    Brucellosis is a zoonotic disease affecting many people and animals worldwide. Preventing this infection requires improving vaccination strategies. The protoxin Cry1Ac of Bacillus thuringiensis is an adjuvant that, in addition to increasing the immunogenicity of different antigens, has shown to be protective in different models of parasitic infections. The objective of the present study was to test whether the intranasal co-administration of pCry1Ac with the RB51 vaccine strain of Brucella abortus confers protection against an intranasal challenge with the virulent strain B. abortus 2308 in BALB/c mice. The results showed that co-administration of pCry1Ac and RB51, increased the immunoprotection conferred by the vaccine as evidenced by the following: (1) decrease of the splenic bacterial load when challenged intranasally with the virulent strain; (2) greater in vivo cytotoxic activity in response to the transference of previously infected cells; (3) further proliferation of cytotoxic TCD8+ cells in response to stimulation with heat-inactivated bacteria; (4) increased production of TNF-α and IFN-γ; and (5) significant IgG2a response. These results indicate that the use of the Cry1Ac protein as a mucosal adjuvant via the intranasal route can be a promising alternative for improving current RB51 vaccine against brucellosis.

  12. Pentoxifylline does not reduce infarct size in a canine model of acute myocardial infarction.

    PubMed Central

    Campbell, C. A.; Clavenna, C. F.; Wynne, J.; Kloner, R. A.

    1988-01-01

    1. The effect of the haemorrheological agent pentoxifylline was investigated in a canine model of acute myocardial infarction, induced by occlusion of the left anterior descending coronary for 6 h. Thirty minutes post-occlusion the dogs were randomized to receive either distilled water or pentoxifylline (0.3 mg kg-1 min-1 for 1 h followed by 0.15 mg kg-1 min-1 for 4.5 h) intravenously. 2. At 6 h post-occlusion the in vivo area at risk was determined with monastral blue dye and the area of necrosis was determined with triphenyltetrazolium chloride. The area at risk was 16.5 +/- 1.3% in the control group (n = 10) and 17.2 +/- 1.8% in the pentoxifylline treated group (n = 10; NS). The area of necrosis was 12.3 +/- 1.9% in the control group and 11.9 +/- 2.2% in the pentoxifylline treated group (NS). The area of necrosis expressed as a percentage of the area at risk was 69.3 +/- 7.7% in the control group and 63.6 +/- 7.4% in the pentoxifylline treated group (NS). 3. Pentoxifylline had no significant effects on heart rate, systolic or diastolic blood pressure. Regional myocardial blood flow, measured by the radioactive microsphere technique, was not significantly different between the groups. 4. Thus, pentoxifylline does not reduce infarct size in this model of acute myocardial infarction and does not enhance coronary collateral blood flow. PMID:3370389

  13. The General Conference Mennonites.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    General Conference Mennonites and Old Order Amish are compared and contrasted in the areas of physical appearance, religious beliefs, formal education, methods of farming, and home settings. General Conference Mennonites and Amish differ in physical appearance and especially in dress. The General Conference Mennonite men and women dress the same…

  14. Parent Conferences. Beginnings Workshop.

    ERIC Educational Resources Information Center

    Duffy, Roslyn; And Others

    1997-01-01

    Presents six workshop sessions on parent conferences: (1) "Parents' Perspectives on Conferencing" (R. Duffy); (2) "Three Way Conferences" (G. Zeller); (3) "Conferencing with Parents of Infants" (K. Albrecht); (4) "Conferencing with Parents of School-Agers" (L. G. Miller); (5) "Cross Cultural Conferences" (J. Gonzalez-Mena); and (6) "Working with…

  15. Mechanics of Textile Composites Conference

    SciTech Connect

    Poe, C.C.; Harris, C.E.

    1995-10-01

    This document is a compilation of papers presented at the Mechanics of Textile Composites Conference in Hampton, Virginia, December 6-8, 1994. This conference was the culmination of a 3-year program that was initiated by NASA late in 1990 to develop mechanics of textile composites in support of the NASA Advance Composites Technology Program (ACT). The goal of the program was to develop mathematical models of textile preform materials and test methods to facilitate structural analysis and design. Participants in the program were from NASA, academia, and industry. Separate abstracts were prepared for articles from this document.

  16. Mechanics of Textile Composites Conference

    NASA Technical Reports Server (NTRS)

    Poe, Clarence C. (Editor); Harris, Charles E. (Editor)

    1995-01-01

    This document is a compilation of papers presented at the Mechanics of Textile Composites Conference in Hampton, Virginia, December 6-8, 1994. This conference was the culmination of a 3-year program that was initiated by NASA late in 1990 to develop mechanics of textile composites in support of the NASA Advance Composites Technology Program (ACT). The goal of the program was to develop mathematical models of textile preform materials and test methods to facilitate structural analysis and design. Participants in the program were from NASA, academia, and industry.

  17. GmSALT3, Which Confers Improved Soybean Salt Tolerance in the Field, Increases Leaf Cl- Exclusion Prior to Na+ Exclusion But Does Not Improve Early Vigor under Salinity

    PubMed Central

    Liu, Ying; Yu, Lili; Qu, Yue; Chen, Jingjing; Liu, Xiexiang; Hong, Huilong; Liu, Zhangxiong; Chang, Ruzhen; Gilliham, Matthew; Qiu, Lijuan; Guan, Rongxia

    2016-01-01

    Soil salinity reduces soybean growth and yield. The recently identified GmSALT3 (Glycine max salt Tolerance-associated gene on chromosome 3) has the potential to improve soybean yields in salinized conditions. Here we evaluate the impact of GmSALT3 on soybean performance under saline or non-saline conditions. Three sets of near isogenic lines (NILs), with genetic similarity of 95.6–99.3% between each pair of NIL-T and NIL-S, were generated from a cross between two varieties 85–140 (salt-sensitive, S) and Tiefeng 8 (salt-tolerant, T) by using marker-assisted selection. Each NIL-T; 782-T, 820-T and 860-T, contained a common ~1000 kb fragment on chromosome 3 where GmSALT3 was located. We show that GmSALT3 does not contribute to an improvement in seedling emergence rate or early vigor under salt stress. However, when 12-day-old seedlings were exposed to NaCl stress, the NIL-T lines accumulated significantly less leaf Na+ compared with their corresponding NIL-S, while no significant difference of K+ concentration was observed between NIL-T and NIL-S; the magnitude of Na+ accumulation within each NIL-T set was influenced by the different genetic backgrounds. In addition, NIL-T lines accumulated less Cl- in the leaf and more in the root prior to any difference in Na+; in the field they accumulated less pod wall Cl- than the corresponding NIL-S lines. Under non-saline field conditions, no significant differences were observed for yield related traits within each pair of NIL-T and NIL-S lines, indicating there was no yield penalty for having the GmSALT3 gene. In contrast, under saline field conditions the NIL-T lines had significantly greater plant seed weight and 100-seed weight than the corresponding NIL-S lines, meaning GmSALT3 conferred a yield advantage to soybean plants in salinized fields. Our results indicated that GmSALT3 mediated regulation of both Na+ and Cl- accumulation in soybean, and contributes to improved soybean yield through maintaining a higher seed

  18. African swine fever virus Georgia isolate harboring deletions of 9GL and MGF360/505 genes is highly attenuated in swine but does not confer protection against parental virus challenge.

    PubMed

    O'Donnell, Vivian; Holinka, Lauren G; Sanford, Brenton; Krug, Peter W; Carlson, Jolene; Pacheco, Juan M; Reese, Bo; Risatti, Guillermo R; Gladue, Douglas P; Borca, Manuel V

    2016-08-01

    African swine fever virus (ASFV) produces a contagious disease of domestic pigs that results in severe economic consequences to the swine industry. Control of the disease has been hampered by the unavailability of vaccines. We recently reported the development of two experimental vaccine strains (ASFV-G-Δ9GL and ASFV-G-ΔMGF) based on the attenuation of the highly virulent and epidemiologically relevant Georgia2007 isolate. Deletion of the 9GL gene or six genes of the MGF360/505 group produced two attenuated ASFV strains which were able to confer protection to animals when challenged with the virulent parental virus. Both viruses, although efficient in inducing protection, present concerns regarding their safety. In an attempt to solve this problem we developed a novel virus strain, ASFV-G-Δ9GL/ΔMGF, based on the deletion of all genes deleted in ASFV-G-Δ9GL and ASFV-G-ΔMGF. ASFV-G-Δ9GL/ΔMGF is the first derivative of a highly virulent ASFV field strain subjected to a double round of recombination events seeking to sequentially delete specific genes. ASFV-G-Δ9GL/ΔMGF showed a decreased ability to replicate in primary swine macrophage cultures relative to that of ASFV-G and ASFV-G-ΔMGF but similar to that of ASFV-G-Δ9GL. ASFV-G-Δ9GL/ΔMGF was attenuated when intramuscularly inoculated into swine, even at doses as high as 10(6) HAD50. Animals infected with doses ranging from 10(2) to 10(6) HAD50 did not present detectable levels of virus in blood at any time post-infection and they did not develop detectable levels of anti-ASFV antibodies. Importantly, ASFV-G-Δ9GL/ΔMGF does not induce protection against challenge with the virulent parental ASFV-G isolate. Results presented here suggest caution towards approaches involving genomic manipulations when developing rationally designed ASFV vaccine strains. PMID:27182007

  19. Evaluating quantitative and conceptual models of speech production: how does SLAM fare?

    PubMed

    Walker, Grant M; Hickok, Gregory

    2016-04-01

    In a previous publication, we presented a new computational model called SLAM (Walker & Hickok, Psychonomic Bulletin & Review doi: 10.3758/s13423-015-0903 ), based on the hierarchical state feedback control (HSFC) theory (Hickok Nature Reviews Neuroscience, 13(2), 135-145, 2012). In his commentary, Goldrick (Psychonomic Bulletin & Review doi: 10.3758/s13423-015-0946-9 ) claims that SLAM does not represent a theoretical advancement, because it cannot be distinguished from an alternative lexical + postlexical (LPL) theory proposed by Goldrick and Rapp (Cognition, 102(2), 219-260, 2007). First, we point out that SLAM implements a portion of a conceptual model (HSFC) that encompasses LPL. Second, we show that SLAM accounts for a lexical bias present in sound-related errors that LPL does not explain. Third, we show that SLAM's explanatory advantage is not a result of approximating the architectural or computational assumptions of LPL, since an implemented version of LPL fails to provide the same fit improvements as SLAM. Finally, we show that incorporating a mechanism that violates some core theoretical assumptions of LPL-making it more like SLAM in terms of interactivity-allows the model to capture some of the same effects as SLAM. SLAM therefore provides new modeling constraints regarding interactions among processing levels, while also elaborating on the structure of the phonological level. We view this as evidence that an integration of psycholinguistic, neuroscience, and motor control approaches to speech production is feasible and may lead to substantial new insights. PMID:26537953

  20. Thirteenth Department of Energy Computer Security Group conference

    SciTech Connect

    Not Available

    1990-01-01

    The theme of the conference is Security Through Teamwork,'' and we have scheduled some very exciting presentations both from within and outside the DOE/Contractor community. this paper contains a list of pre-conference workshops that will be presented at this meeting.

  1. Gatlinburg conference: barometer of progress in analytical chemistry

    SciTech Connect

    Shults, W.D.

    1981-01-01

    Much progress has been made in the field of analytical chemistry over the past twenty-five years. The AEC-ERDA-DOE family of laboratories contributed greatly to this progress. It is not surprising then to find a close correlation between program content of past Gatlinburg conferences and developments in analytical methodology. These conferences have proved to be a barometer of technical status.

  2. Message from the Conference Chairs

    NASA Astrophysics Data System (ADS)

    Krishna, Sanjay; Perera, Unil

    2015-05-01

    We were very excited to host the 8th International Workshop on Quantum Structure Infrared Photodetectors (QSIP 2014), in picturesque Santa Fe, New Mexico from June 29th-July 3rd, 2014. This followed successful QSIP conferences at Dana Point (2000), Torino (2002), Kananaskis (2004), Kandy (2006), Yosimite (2009), Istanbul (2010) and Corsica (2012). The QSIP workshop is a high level scientific conference that aims to bring together scientists, engineers, industrial organizations, students and users in order to discuss recent advances, and to share the "State of the Art" in this field. QSIP conferences provide an international forum for attendees to present and discuss progress in infrared device physics and modeling, materials growth and processing issues, focal plane array development and characterization.

  3. A Practitioner's Guide to Science-Based Prevention: A Handbook of Promising, Effective and Model Programs. 2002 Conference Edition.

    ERIC Educational Resources Information Center

    Schinke, Steven

    The importance of science-based programs is now widely acknowledged in the substance abuse prevention field. The Center for Substance Abuse Prevention (CSAP) continues its efforts on several fronts to inform the field of the existence and availability of science-based program options. It primarily does this through its National Registry of…

  4. Re-Evaluating Neonatal-Age Models for Ungulates: Does Model Choice Affect Survival Estimates?

    PubMed Central

    Grovenburg, Troy W.; Monteith, Kevin L.; Jacques, Christopher N.; Klaver, Robert W.; DePerno, Christopher S.; Brinkman, Todd J.; Monteith, Kyle B.; Gilbert, Sophie L.; Smith, Joshua B.; Bleich, Vernon C.; Swanson, Christopher C.; Jenks, Jonathan A.

    2014-01-01

    New-hoof growth is regarded as the most reliable metric for predicting age of newborn ungulates, but variation in estimated age among hoof-growth equations that have been developed may affect estimates of survival in staggered-entry models. We used known-age newborns to evaluate variation in age estimates among existing hoof-growth equations and to determine the consequences of that variation on survival estimates. During 2001–2009, we captured and radiocollared 174 newborn (≤24-hrs old) ungulates: 76 white-tailed deer (Odocoileus virginianus) in Minnesota and South Dakota, 61 mule deer (O. hemionus) in California, and 37 pronghorn (Antilocapra americana) in South Dakota. Estimated age of known-age newborns differed among hoof-growth models and varied by >15 days for white-tailed deer, >20 days for mule deer, and >10 days for pronghorn. Accuracy (i.e., the proportion of neonates assigned to the correct age) in aging newborns using published equations ranged from 0.0% to 39.4% in white-tailed deer, 0.0% to 3.3% in mule deer, and was 0.0% for pronghorns. Results of survival modeling indicated that variability in estimates of age-at-capture affected short-term estimates of survival (i.e., 30 days) for white-tailed deer and mule deer, and survival estimates over a longer time frame (i.e., 120 days) for mule deer. Conversely, survival estimates for pronghorn were not affected by estimates of age. Our analyses indicate that modeling survival in daily intervals is too fine a temporal scale when age-at-capture is unknown given the potential inaccuracies among equations used to estimate age of neonates. Instead, weekly survival intervals are more appropriate because most models accurately predicted ages within 1 week of the known age. Variation among results of neonatal-age models on short- and long-term estimates of survival for known-age young emphasizes the importance of selecting an appropriate hoof-growth equation and appropriately defining intervals (i.e., weekly

  5. Re-evaluating neonatal-age models for ungulates: does model choice affect survival estimates?

    PubMed

    Grovenburg, Troy W; Monteith, Kevin L; Jacques, Christopher N; Klaver, Robert W; DePerno, Christopher S; Brinkman, Todd J; Monteith, Kyle B; Gilbert, Sophie L; Smith, Joshua B; Bleich, Vernon C; Swanson, Christopher C; Jenks, Jonathan A

    2014-01-01

    New-hoof growth is regarded as the most reliable metric for predicting age of newborn ungulates, but variation in estimated age among hoof-growth equations that have been developed may affect estimates of survival in staggered-entry models. We used known-age newborns to evaluate variation in age estimates among existing hoof-growth equations and to determine the consequences of that variation on survival estimates. During 2001-2009, we captured and radiocollared 174 newborn (≤24-hrs old) ungulates: 76 white-tailed deer (Odocoileus virginianus) in Minnesota and South Dakota, 61 mule deer (O. hemionus) in California, and 37 pronghorn (Antilocapra americana) in South Dakota. Estimated age of known-age newborns differed among hoof-growth models and varied by >15 days for white-tailed deer, >20 days for mule deer, and >10 days for pronghorn. Accuracy (i.e., the proportion of neonates assigned to the correct age) in aging newborns using published equations ranged from 0.0% to 39.4% in white-tailed deer, 0.0% to 3.3% in mule deer, and was 0.0% for pronghorns. Results of survival modeling indicated that variability in estimates of age-at-capture affected short-term estimates of survival (i.e., 30 days) for white-tailed deer and mule deer, and survival estimates over a longer time frame (i.e., 120 days) for mule deer. Conversely, survival estimates for pronghorn were not affected by estimates of age. Our analyses indicate that modeling survival in daily intervals is too fine a temporal scale when age-at-capture is unknown given the potential inaccuracies among equations used to estimate age of neonates. Instead, weekly survival intervals are more appropriate because most models accurately predicted ages within 1 week of the known age. Variation among results of neonatal-age models on short- and long-term estimates of survival for known-age young emphasizes the importance of selecting an appropriate hoof-growth equation and appropriately defining intervals (i.e., weekly

  6. Re-evaluating neonatal-age models for ungulates: Does model choice affect survival estimates?

    USGS Publications Warehouse

    Grovenburg, Troy W.; Monteith, Kevin L.; Jacques, Christopher N.; Klaver, Robert W.; DePerno, Christopher S.; Brinkman, Todd J.; Monteith, Kyle B.; Gilbert, Sophie L.; Smith, Joshua B.; Bleich, Vernon C.; Swanson, Christopher C.; Jenks, Jonathan A.

    2014-01-01

    New-hoof growth is regarded as the most reliable metric for predicting age of newborn ungulates, but variation in estimated age among hoof-growth equations that have been developed may affect estimates of survival in staggered-entry models. We used known-age newborns to evaluate variation in age estimates among existing hoof-growth equations and to determine the consequences of that variation on survival estimates. During 2001–2009, we captured and radiocollared 174 newborn (≤24-hrs old) ungulates: 76 white-tailed deer (Odocoileus virginianus) in Minnesota and South Dakota, 61 mule deer (O. hemionus) in California, and 37 pronghorn (Antilocapra americana) in South Dakota. Estimated age of known-age newborns differed among hoof-growth models and varied by >15 days for white-tailed deer, >20 days for mule deer, and >10 days for pronghorn. Accuracy (i.e., the proportion of neonates assigned to the correct age) in aging newborns using published equations ranged from 0.0% to 39.4% in white-tailed deer, 0.0% to 3.3% in mule deer, and was 0.0% for pronghorns. Results of survival modeling indicated that variability in estimates of age-at-capture affected short-term estimates of survival (i.e., 30 days) for white-tailed deer and mule deer, and survival estimates over a longer time frame (i.e., 120 days) for mule deer. Conversely, survival estimates for pronghorn were not affected by estimates of age. Our analyses indicate that modeling survival in daily intervals is too fine a temporal scale when age-at-capture is unknown given the potential inaccuracies among equations used to estimate age of neonates. Instead, weekly survival intervals are more appropriate because most models accurately predicted ages within 1 week of the known age. Variation among results of neonatal-age models on short- and long-term estimates of survival for known-age young emphasizes the importance of selecting an appropriate hoof-growth equation and appropriately defining intervals (i.e., weekly

  7. Re-evaluating neonatal-age models for ungulates: does model choice affect survival estimates?

    PubMed

    Grovenburg, Troy W; Monteith, Kevin L; Jacques, Christopher N; Klaver, Robert W; DePerno, Christopher S; Brinkman, Todd J; Monteith, Kyle B; Gilbert, Sophie L; Smith, Joshua B; Bleich, Vernon C; Swanson, Christopher C; Jenks, Jonathan A

    2014-01-01

    New-hoof growth is regarded as the most reliable metric for predicting age of newborn ungulates, but variation in estimated age among hoof-growth equations that have been developed may affect estimates of survival in staggered-entry models. We used known-age newborns to evaluate variation in age estimates among existing hoof-growth equations and to determine the consequences of that variation on survival estimates. During 2001-2009, we captured and radiocollared 174 newborn (≤24-hrs old) ungulates: 76 white-tailed deer (Odocoileus virginianus) in Minnesota and South Dakota, 61 mule deer (O. hemionus) in California, and 37 pronghorn (Antilocapra americana) in South Dakota. Estimated age of known-age newborns differed among hoof-growth models and varied by >15 days for white-tailed deer, >20 days for mule deer, and >10 days for pronghorn. Accuracy (i.e., the proportion of neonates assigned to the correct age) in aging newborns using published equations ranged from 0.0% to 39.4% in white-tailed deer, 0.0% to 3.3% in mule deer, and was 0.0% for pronghorns. Results of survival modeling indicated that variability in estimates of age-at-capture affected short-term estimates of survival (i.e., 30 days) for white-tailed deer and mule deer, and survival estimates over a longer time frame (i.e., 120 days) for mule deer. Conversely, survival estimates for pronghorn were not affected by estimates of age. Our analyses indicate that modeling survival in daily intervals is too fine a temporal scale when age-at-capture is unknown given the potential inaccuracies among equations used to estimate age of neonates. Instead, weekly survival intervals are more appropriate because most models accurately predicted ages within 1 week of the known age. Variation among results of neonatal-age models on short- and long-term estimates of survival for known-age young emphasizes the importance of selecting an appropriate hoof-growth equation and appropriately defining intervals (i.e., weekly

  8. Summary of activities for DOE Award DE-FG02-02ER63444 for "Modeling dynamic vegetation for decadal to multi-century climate change studies"

    SciTech Connect

    Nancy Y. Kiang

    2005-09-26

    This is a summary of all activities that were funded by the DOE Award DE-FG02-02ER63444, ''Modeling dynamic vegetation for decadal to multi-century climate change studies'', during the period 09/01/2001-11/30/2004. The goal of this research has been to produce a process-based vegetation activity model suitable for coupling with a general circulation model (GCM) of the atmosphere, to simulate the biophysics of vegetation transpiration and photosynthesis, seasonal growth, and vegetation cover change. The model was to be developed within the NASA Goddard Institute for Space Studies (GISS) GCM. The model as envisioned in the original proposal was to be an adaptation of Dr. Friend's previous well-known dynamic vegetation model, HYBRID (Friend, et.al., 1997; Friend and White, 2000). After examining the issues of GCM model coupling, Dr. Friend realized some of the complexities of HYBRID would not be computationally suitable for the GCM. He wrote a review paper on ''big-leaf'' modeling issues (Friend, 2001), and concentrated on developing a new vegetation biophysics approach, which involved a computationally simply canopy-level conductance scheme (thus avoiding the problem of leaf-to-canopy scaling) and photosynthesis based on the work of Kull and Kruijt (1998), which distinguished the portion of leaf nitrogen that is photosynthetic. Dr. Friend presented the results photosynthesis/conductance scheme coupled to the Model II version of the GISS GCM (Hansen, et.al., 1983) in a talk at the 2002 AGU Fall Meeting in San Francisco. After Dr. Kiang arrived in April 2003, she, Dr. Friend, and Dr. Aleinov implemented the new scheme in the Model E version of the GISS GCM (Schmidt, et.al., accepted), and published results of improved surface temperatures and cloud cover in the Journal of Climate (Friend and Kiang, 2005). Till the end of the award period, Dr. Friend continued to develop a new vegetation growth model involving nitrogen allocation to light-stratified canopy layers

  9. Closed Conference Signalling Using the Session Initiation Protocol.

    ERIC Educational Resources Information Center

    Miladinovic, Igor; Stadler, Johannes

    2003-01-01

    Introduces an extension of the Session Initiation Protocol (SIP) for closed multiparty conferences; the extension expands SIP for discovery of participant identities in a conference, and ensures that each participant is notified before a new participant joins. Verifies this extension by applying it to two SIP conference models. Concludes with an…

  10. Does the Sverdrup critical depth model explain bloom dynamics in estuaries?

    USGS Publications Warehouse

    Lucas, L.V.; Cloern, J.E.; Koseff, Jeffrey R.; Monismith, Stephen G.; Thompson, J.K.

    1998-01-01

    In this paper we use numerical models of coupled biological-hydrodynamic processes to search for general principles of bloom regulation in estuarine waters. We address three questions: what are the dynamics of stratification in coastal systems as influenced by variable freshwater input and tidal stirring? How does phytoplankton growth respond to these dynamics? Can the classical Sverdrup Critical Depth Model (SCDM) be used to predict the timing of bloom events in shallow coastal domains such as estuaries? We present results of simulation experiments which assume that vertical transport and net phytoplankton growth rates are horizontally homogeneous. In the present approach the temporally and spatially varying turbulent diffusivities for various stratification scenarios are calculated using a hydrodynamic code that includes the Mellor-Yamada 2.5 turbulence closure model. These diffusivities are then used in a time- and depth-dependent advection-diffusion equation, incorporating sources and sinks, for the phytoplankton biomass. Our modeling results show that, whereas persistent stratification greatly increases the probability of a bloom, semidiurnal periodic stratification does not increase the likelihood of a phytoplankton bloom over that of a constantly unstratified water column. Thus, for phytoplankton blooms, the physical regime of periodic stratification is closer to complete mixing than to persistent stratification. Furthermore, the details of persistent stratification are important: surface layer depth, thickness of the pycnocline, vertical density difference, and tidal current speed all weigh heavily in producing conditions which promote the onset of phytoplankton blooms. Our model results for shallow tidal systems do not conform to the classical concepts of stratification and blooms in deep pelagic systems. First, earlier studies (Riley, 1942, for example) suggest a monotonic increase in surface layer production as the surface layer shallows. Our model

  11. Expand the Modeling Capabilities of DOE's EnergyPlus Building Energy Simulation Program

    SciTech Connect

    Don Shirey

    2008-02-28

    EnergyPlus{trademark} is a new generation computer software analysis tool that has been developed, tested, and commercialized to support DOE's Building Technologies (BT) Program in terms of whole-building, component, and systems R&D (http://www.energyplus.gov). It is also being used to support evaluation and decision making of zero energy building (ZEB) energy efficiency and supply technologies during new building design and existing building retrofits. Version 1.0 of EnergyPlus was released in April 2001, followed by semiannual updated versions over the ensuing seven-year period. This report summarizes work performed by the University of Central Florida's Florida Solar Energy Center (UCF/FSEC) to expand the modeling capabilities of EnergyPlus. The project tasks involved implementing, testing, and documenting the following new features or enhancement of existing features: (1) A model for packaged terminal heat pumps; (2) A model for gas engine-driven heat pumps with waste heat recovery; (3) Proper modeling of window screens; (4) Integrating and streamlining EnergyPlus air flow modeling capabilities; (5) Comfort-based controls for cooling and heating systems; and (6) An improved model for microturbine power generation with heat recovery. UCF/FSEC located existing mathematical models or generated new model for these features and incorporated them into EnergyPlus. The existing or new models were (re)written using Fortran 90/95 programming language and were integrated within EnergyPlus in accordance with the EnergyPlus Programming Standard and Module Developer's Guide. Each model/feature was thoroughly tested and identified errors were repaired. Upon completion of each model implementation, the existing EnergyPlus documentation (e.g., Input Output Reference and Engineering Document) was updated with information describing the new or enhanced feature. Reference data sets were generated for several of the features to aid program users in selecting proper model inputs. An

  12. Use of DOE SGP Radars in Support of ASR Modeling Activities

    SciTech Connect

    Rutledge, Steven A.

    2015-12-13

    The objective of this work was to use the DOE Southern Great Plains (SGP) precipitation radars to investigate physical characteristics of clouds and precipitation, and use this knowledge in support of DOE ASR modeling efforts. The goal was to develop an integrated data set based on the SGP instrumentation to yield statistically robust fields to aid in the task of verifying simulated cloud dynamical and microphysical fields. For this effort we relied heavily on the ARM scanning precipitation radars, X-SAPR’s and C-SAPR, and also incorporating data from wind profilers, surface disdrometers and the nearby WSR-88D radar, KVNX. Initially we lent our expertise to quality controlling the data from the newly installed ARM radars, particularly the X-band polarimetric data, and additionally assessed automatic radial velocity unfolding algorithms developed by other ASR researchers. We focused our efforts on four cases from the MC3E field campaign in 2011 and developed a dataset including microphysical information derived from hydrometeor identification and kinematic analysis using multiple-Doppler retrieval techniques. This dataset became a PI product and was released to the community in 2014. This analysis was used to investigate the source of big drops (> 5 mm) observed with disdrometers at the surface. It was found that the big drops were coincident with the strongest updrafts, suggesting they resulted from the melting of large precipitation ice, likely hail. We teamed up with W-K Tao and T. Matsui to statistically compare radar-derived observational kinematics and microphysics to WRF model output for the 25 April 2011. Comparisons highlighted some areas where the model may need improvement, such as generating too much hail and big drops, as well as overly-strong updrafts and overly-weak of downdrafts.

  13. Selected Papers Presented at MODSIM World 2011 Conference and Expo

    NASA Technical Reports Server (NTRS)

    Pinelli, Thomas E. (Compiler); Bullock, Leanna S. (Compiler)

    2012-01-01

    Selected papers from MODSIM World 2011 Conference & Expo are contained in this NASA Conference Publication (CP). MODSIM World 2011 was held in Virginia Beach, Virginia, October 11-14, 2011. The theme of the 2011 conference & expo was "Overcoming Critical Global Challenges with Modeling & Simulation". The conference program consisted of five technical tracks - Defense, Homeland Security & First Responders; Education; Health & Medicine; The Human Dimension; and Serious Games & Virtual Worlds.

  14. Apollo 13 Facts: Press Conference

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Flight Director Gene Krantz gives an overview of the Apollo 13 mission as corrections are made in the power down checklist, passive thermal control, and orbital burns after the spacecraft runs into problems. He then answers questions from the press with the help of Tony England, Bill Peters, and Dick Thorson. Footage then shows newspaper headlines 'We're Not Concerned' and 'Getting Ready to Land' as people watch televisions to see if the astronauts landed safely. The press conference section of this video has sound, the headlines section does not.

  15. Grambling State University's Planning/Budgeting Model: An Integral Component of a Decision Support System. SAIR Conference Paper.

    ERIC Educational Resources Information Center

    Lundy, Harold W.

    The development of a planning/budgeting model as an integral component of a decision support system is described. The case study approach is used to describe how Grambling State University (GSU) developed the model to improve its financial planning and budgeting processes. The model can be used for tactical and/or strategic planning. The model is…

  16. SOFTWARE QUALITY ASSURANCE FOR EMERGENCY RESPONSE CONSEQUENCE ASSESSMENT MODELS AT DOE'S SAVANNAH RIVER SITE

    SciTech Connect

    Hunter, C

    2007-12-17

    The Savannah River National Laboratory's (SRNL) Atmospheric Technologies Group develops, maintains, and operates computer-based software applications for use in emergency response consequence assessment at DOE's Savannah River Site. These applications range from straightforward, stand-alone Gaussian dispersion models run with simple meteorological input to complex computational software systems with supporting scripts that simulate highly dynamic atmospheric processes. A software quality assurance program has been developed to ensure appropriate lifecycle management of these software applications. This program was designed to meet fully the overall structure and intent of SRNL's institutional software QA programs, yet remain sufficiently practical to achieve the necessary level of control in a cost-effective manner. A general overview of this program is described.

  17. General Relativity and the Standard Model: Why evidence for one does not disconfirm the other

    NASA Astrophysics Data System (ADS)

    Jones, Nicholaos

    General Relativity and the Standard Model often are touted as the most rigorously and extensively confirmed scientific hypotheses of all time. Nonetheless, these theories appear to have consequences that are inconsistent with evidence about phenomena for which, respectively, quantum effects and gravity matter. This paper suggests an explanation for why the theories are not disconfirmed by such evidence. The key to this explanation is an approach to scientific hypotheses that allows their actual content to differ from their apparent content. This approach does not appeal to ceteris-paribus qualifiers or counterfactuals or similarity relations. And it helps to explain why some highly idealized hypotheses are not treated in the way that a thoroughly refuted theory is treated but instead as hypotheses with limited domains of applicability.

  18. 2013 Community Earth System Model (CESM) Tutorial-Proposal to DOE

    SciTech Connect

    Holland, Marika; Bates, Susan

    2014-12-04

    THE SAME REQUEST WILL BE SENT TO BOTH NSF AND DOE TO EACH SUPPORT $35K. The third annual Community Earth System Model (CESM) tutorial for students and early career scientists was held from 30 July to 3 August, 2012. This event was extremely successful and, as for the tutorials in previous years, there was a greater demand than could be met. This indicates a continuing need for a tutorial of this type and we anticipate that the 2013 tutorial will be well received. The tutorial will include lectures on simulating the climate system and practical sessions on running CESM, modifying components, and analyzing data. These will be targeted to the graduate student level. Attendance will be limited to a maximum of 80 students with financial support for up to 40 students. Attendees will be balanced across institutions.

  19. Proceedings of the 1987 winter simulation conference

    SciTech Connect

    Thesen, A.; Grant, H.; Kelton, W.D.

    1988-01-01

    This book contains papers presented at a conference on Computerized Simulation. Topics include the following: Model generating input processes; generalized zero invariance and intelligent random numbers; computerized simulation of array processors; and computerized simulation for traffic control.

  20. Proceedings of the Spacecraft Charging Technology Conference

    NASA Technical Reports Server (NTRS)

    Pike, C. P. (Editor); Lovell, R. R. (Editor)

    1977-01-01

    Over 50 papers from the spacecraft charging conference are included on subjects such as: (1) geosynchronous plasma environment, (2) spacecraft modeling, (3) spacecraft materials characterization, (4) spacecraft materials development, and (5) satellite design and test.

  1. Patient-specific computer modelling of coronary bifurcation stenting: the John Doe programme.

    PubMed

    Mortier, Peter; Wentzel, Jolanda J; De Santis, Gianluca; Chiastra, Claudio; Migliavacca, Francesco; De Beule, Matthieu; Louvard, Yves; Dubini, Gabriele

    2015-01-01

    John Doe, an 81-year-old patient with a significant distal left main (LM) stenosis, was treated using a provisional stenting approach. As part of an European Bifurcation Club (EBC) project, the complete stenting procedure was repeated using computational modelling. First, a tailored three-dimensional (3D) reconstruction of the bifurcation anatomy was created by fusion of multislice computed tomography (CT) imaging and intravascular ultrasound. Second, finite element analysis was employed to deploy and post-dilate the stent virtually within the generated patient-specific anatomical bifurcation model. Finally, blood flow was modelled using computational fluid dynamics. This proof-of-concept study demonstrated the feasibility of such patient-specific simulations for bifurcation stenting and has provided unique insights into the bifurcation anatomy, the technical aspects of LM bifurcation stenting, and the positive impact of adequate post-dilatation on blood flow patterns. Potential clinical applications such as virtual trials and preoperative planning seem feasible but require a thorough clinical validation of the predictive power of these computer simulations.

  2. Does inflation solve the hot big bang model's fine-tuning problems?

    NASA Astrophysics Data System (ADS)

    McCoy, C. D.

    2015-08-01

    Cosmological inflation is widely considered an integral and empirically successful component of contemporary cosmology. It was originally motivated (and usually still is) by its solution of certain so-called fine-tuning problems of the hot big bang model, particularly what are known as the horizon problem and the flatness problem. Although the physics behind these problems is clear enough, the nature of the problems depends on the sense in which the hot big bang model is fine-tuned and how the alleged fine-tuning is problematic. Without clear explications of these, it remains unclear precisely what problems inflationary theory is meant to be solving and whether it does in fact solve them. I analyze the structure of these problems and consider various interpretations that may substantiate the alleged fine-tuning. On the basis of this analysis I argue that at present there is no unproblematic interpretation available for which it can be said that inflation solves the big bang model's alleged fine-tuning problems.

  3. Repetitive live sporozoites inoculation under arteether chemoprophylaxis confers protection against subsequent sporozoite challenge in rodent malaria model.

    PubMed

    Bhardwaj, Jyoti; Siddiqui, Arif Jamal; Goyal, Manish; Prakash, Kirtika; Soni, Awakash; Puri, Sunil K

    2016-06-01

    Inoculation with live sporozoites under prophylactic antimalarial cover (CPS-immunization) represents an alternate approach to develop sterile, reproducible, and long-term protection against malaria. Here, we have employed arteether (ART), a semi synthetic derivative of artemisinin to explore its potential as a chemoprophylaxis candidate in CPS approach and systematically compared the protective potential of arteether with mefloquine, azithromycin and primaquine. Blood stage patency and quantitative RT-PCR of liver stage parasite load were monitored as primary key end-points for protection against malaria challenge infection. For this purpose, sequential exposures of Plasmodium yoelii sporozoites under prophylactic treatment with arteether (ART), mefloquine (MFQ), azithromycin (AZ) or primaquine (PQ) was conducted in experimental Swiss mice. Our results show that during the first three sequential exposures (1st, 2nd and 3rd challenge) no marked difference in the blood stage patency was observed between control and CPS-ART group. However, delayed patency was recorded following 4th sporozoite challenge and mice enjoyed sterile protection after 5th sporozoite challenge. A similar response was observed in CPS-MFQ group, whereas earlier protection was recorded in CPS-AZ group i.e., after 4th sprozoite challenge. However, mice under PQ cover did not show any protection/delay in patency even after five sequential sporozoite inoculations, possibly due to inhibition of liver stage development. Furthermore, protection acquired by CPS-immunization is stage-specific as the protected mice remained susceptible to challenge with blood stage parasites. In short, the present study demonstrates that sporozoite administration under ART, MFQ or AZ treatment confers strong protection against subsequent sporozoite infection and the acquired response is dependent on the presence of liver stage parasites.

  4. 2006 environmental controls conference

    SciTech Connect

    2006-07-01

    The two topics covered at the conference were: selective catalytic reduction (SCR) and selection non-catalytic reduction (SNCR) for NOx control, and techniques for managing sulfur trioxide. A total of 45 presentations are summarized on the NETL website of which 22 are available in full. These include keynote addresses for each of the two major topics. In addition four poster papers are listed. The papers are arranged in sections headed: regulatory considerations; overview of SCR/SNCR; managing SCR catalysts; gas monitoring and analysis; predictive performance tools; non-coal applications; layered SCR; flow distribution and modeling; hybrid systems; innovative applications; SO{sub 2} conversion to SO{sub 3}; SO{sub 3} overview; acid gas control issues; sorbent injection for acid gas migration; and effects of SO{sub 3} on mercury control.

  5. Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5.

    PubMed

    Keniya, Mikhail V; Holmes, Ann R; Niimi, Masakazu; Lamping, Erwin; Gillet, Jean-Pierre; Gottesman, Michael M; Cannon, Richard D

    2014-10-01

    ABCB5, an ATP-binding cassette (ABC) transporter, is highly expressed in melanoma cells, and may contribute to the extreme resistance of melanomas to chemotherapy by efflux of anti-cancer drugs. Our goal was to determine whether we could functionally express human ABCB5 in the model yeast Saccharomyces cerevisiae, in order to demonstrate an efflux function for ABCB5 in the absence of background pump activity from other human transporters. Heterologous expression would also facilitate drug discovery for this important target. DNAs encoding ABCB5 sequences were cloned into the chromosomal PDR5 locus of a S. cerevisiae strain in which seven endogenous ABC transporters have been deleted. Protein expression in the yeast cells was monitored by immunodetection using both a specific anti-ABCB5 antibody and a cross-reactive anti-ABCB1 antibody. ABCB5 function in recombinant yeast cells was measured by determining whether the cells possessed increased resistance to known pump substrates, compared to the host yeast strain, in assays of yeast growth. Three ABCB5 constructs were made in yeast. One was derived from the ABCB5-β mRNA, which is highly expressed in human tissues but is a truncation of a canonical full-size ABC transporter. Two constructs contained full-length ABCB5 sequences: either a native sequence from cDNA or a synthetic sequence codon-harmonized for S. cerevisiae. Expression of all three constructs in yeast was confirmed by immunodetection. Expression of the codon-harmonized full-length ABCB5 DNA conferred increased resistance, relative to the host yeast strain, to the putative substrates rhodamine 123, daunorubicin, tetramethylrhodamine, FK506, or clorgyline. We conclude that full-length ABCB5 can be functionally expressed in S. cerevisiae and confers drug resistance. PMID:25115303

  6. Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5.

    PubMed

    Keniya, Mikhail V; Holmes, Ann R; Niimi, Masakazu; Lamping, Erwin; Gillet, Jean-Pierre; Gottesman, Michael M; Cannon, Richard D

    2014-10-01

    ABCB5, an ATP-binding cassette (ABC) transporter, is highly expressed in melanoma cells, and may contribute to the extreme resistance of melanomas to chemotherapy by efflux of anti-cancer drugs. Our goal was to determine whether we could functionally express human ABCB5 in the model yeast Saccharomyces cerevisiae, in order to demonstrate an efflux function for ABCB5 in the absence of background pump activity from other human transporters. Heterologous expression would also facilitate drug discovery for this important target. DNAs encoding ABCB5 sequences were cloned into the chromosomal PDR5 locus of a S. cerevisiae strain in which seven endogenous ABC transporters have been deleted. Protein expression in the yeast cells was monitored by immunodetection using both a specific anti-ABCB5 antibody and a cross-reactive anti-ABCB1 antibody. ABCB5 function in recombinant yeast cells was measured by determining whether the cells possessed increased resistance to known pump substrates, compared to the host yeast strain, in assays of yeast growth. Three ABCB5 constructs were made in yeast. One was derived from the ABCB5-β mRNA, which is highly expressed in human tissues but is a truncation of a canonical full-size ABC transporter. Two constructs contained full-length ABCB5 sequences: either a native sequence from cDNA or a synthetic sequence codon-harmonized for S. cerevisiae. Expression of all three constructs in yeast was confirmed by immunodetection. Expression of the codon-harmonized full-length ABCB5 DNA conferred increased resistance, relative to the host yeast strain, to the putative substrates rhodamine 123, daunorubicin, tetramethylrhodamine, FK506, or clorgyline. We conclude that full-length ABCB5 can be functionally expressed in S. cerevisiae and confers drug resistance.

  7. Does IR = Institutional Retrenchment? Perspectives on the Role of Institutional Research in a Time of Retrenchment. Papers from the Annual Conference of the North East Association for Institutional Research (4th, Durham, NH, October 27, 28, and 29, 1977).

    ERIC Educational Resources Information Center

    North East Association for Institutional Research.

    The conference focused on various perspectives of the role of institutional research in a time of retrenchment: policy analysis, economic assumptions, resource management, academic planning and cooperative statewide planning. Among the themes addressed were: enrollment projections and financial planning; institutional efficiency and effectiveness;…

  8. Does probabilistic modelling of linkage disequilibrium evolution improve the accuracy of QTL location in animal pedigree?

    PubMed Central

    2010-01-01

    Background Since 2001, the use of more and more dense maps has made researchers aware that combining linkage and linkage disequilibrium enhances the feasibility of fine-mapping genes of interest. So, various method types have been derived to include concepts of population genetics in the analyses. One major drawback of many of these methods is their computational cost, which is very significant when many markers are considered. Recent advances in technology, such as SNP genotyping, have made it possible to deal with huge amount of data. Thus the challenge that remains is to find accurate and efficient methods that are not too time consuming. The study reported here specifically focuses on the half-sib family animal design. Our objective was to determine whether modelling of linkage disequilibrium evolution improved the mapping accuracy of a quantitative trait locus of agricultural interest in these populations. We compared two methods of fine-mapping. The first one was an association analysis. In this method, we did not model linkage disequilibrium evolution. Therefore, the modelling of the evolution of linkage disequilibrium was a deterministic process; it was complete at time 0 and remained complete during the following generations. In the second method, the modelling of the evolution of population allele frequencies was derived from a Wright-Fisher model. We simulated a wide range of scenarios adapted to animal populations and compared these two methods for each scenario. Results Our results indicated that the improvement produced by probabilistic modelling of linkage disequilibrium evolution was not significant. Both methods led to similar results concerning the location accuracy of quantitative trait loci which appeared to be mainly improved by using four flanking markers instead of two. Conclusions Therefore, in animal half-sib designs, modelling linkage disequilibrium evolution using a Wright-Fisher model does not significantly improve the accuracy of the

  9. DOE pollution prevention in the 21st century. Proceedings

    SciTech Connect

    Not Available

    1996-12-31

    This CD-ROM contains the proceedings from the DOE Pollution Prevention in the 21st Century Conference XII held July 9-11, 1996. Topics included model facilities, federal and NEPA stakeholders, microchemistry, source 4 solvents and reduction, education and outreach planning, return on investment, energy management, decontamination and decommissioning, planning and regulations, environmental restoration, solid waste, recycling, affirmative procurement in the executive branch, construction and demolition, international and ISO 14000, and poster sessions.

  10. DOE pollution prevention in the 21st century

    SciTech Connect

    1996-10-01

    This document presents abstracts of the topics covered in the DOE Pollution Prevention in the 21st Century conference held July 9-11, 1996. These topics include: model facilities; Federal/NEPA/stake- holders; microchemistry; solvents and reduction; education and outreach; return on investments; energy management; decontamination and decommissioning; planning and regulations; environmental restoration; recycling; affirmative procurement in the executive branch; construction and demolition; materials exchange; and ISO 2000.

  11. 1993 Department of Energy Records Management Conference

    SciTech Connect

    1993-12-31

    This document consists of viewgraphs from the presentations at the conference. Topics included are: DOE records management overview, NIRMA and ARMA resources, NARA records management training, potential quality assurance records, filing systems, organizing and indexing technical records, DOE-HQ initiatives, IRM reviews, status of epidemiologic inventory, disposition of records and personal papers, inactive records storage, establishing administrative records, managing records at Hanford, electronic mail -- legal and records issues, NARA-GAO reports status, consultive selling, automated indexing, decentralized approach to scheduling at a DOE office, developing specific records management programs, storage and retrieval at Savannah River Plant, an optical disk case study, and special interest group reports.

  12. Recent developments: USCEA fuel cycle 1990 conference

    SciTech Connect

    1990-04-01

    At the US Council for Energy Awareness Fuel Cycle 1990 Conference in Nashville, Tennessee, held March 25-28, discussions centered on the many changes occurring in the industry, particularly regarding increased internationalization of suppliers. The future of the enrichment market held a prominent place in conversation, as participants speculated about the future of DOE, Louisiana Energy Services (LES), the possibility of an Australian enrichment plant, and Technsnabexport`s growing role in the marketplace. Summaries of some of the papers presented at the conference follow.

  13. 25 CFR 900.158 - How does an Indian tribe or tribal organization appeal the initial decision, if it does not...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... tribal organization appeal the initial decision, if it does not request an informal conference or if it... 25 Indians 2 2010-04-01 2010-04-01 false How does an Indian tribe or tribal organization appeal the initial decision, if it does not request an informal conference or if it does not agree with...

  14. 76 FR 64083 - Reliability Technical Conference; Notice of Technical Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Reliability Technical Conference; Notice of Technical Conference Take notice that the Federal Energy Regulatory Commission will hold a Technical Conference on Tuesday, November...

  15. Does introduced fauna influence soil erosion? A field and modelling assessment.

    PubMed

    Hancock, G R; Lowry, J B C; Dever, C; Braggins, M

    2015-06-15

    Pigs (Sus scrofa) are recognised as having significant ecological impacts in many areas of the world including northern Australia. The full consequences of the introduction of pigs are difficult to quantify as the impacts may only be detected over the long-term and there is a lack of quantitative information on the impacts of feral pigs globally. In this study the effect of feral pigs is quantified in an undisturbed catchment in the monsoonal tropics of northern Australia. Over a three-year period, field data showed that the areal extent of pig disturbance ranged from 0.3-3.3% of the survey area. The mass of material exhumed through these activities ranged from 4.3 t ha(-1) yr(-1) to 36.0 t ha(-1) yr(-1). The findings demonstrate that large introduced species such as feral pigs are disturbing large areas as well as exhuming considerable volumes of soil. A numerical landscape evolution and soil erosion model was used to assess the effect of this disturbance on catchment scale erosion rates. The modelling demonstrated that simulated pig disturbance in previously undisturbed areas produced lower erosion rates compared to those areas which had not been impacted by pigs. This is attributed to the pig disturbance increasing surface roughness and trapping sediment. This suggests that in this specific environment, disturbance by pigs does not enhance erosion. However, this conclusion is prefaced by two important caveats. First, the long term impact of soil disturbance is still very uncertain. Secondly, modelling results show a clear differentiation between those from an undisturbed environment and those from a post-mining landscape, in which pig disturbance may enhance erosion.

  16. Corrosion/96 conference papers

    SciTech Connect

    1996-07-01

    Topics covered by this conference include: cathodic protection in natural waters; cleaning and repassivation of building HVAC systems; worldwide opportunities in flue gas desulfurization; advancements in materials technology for use in oil and gas service; fossil fuel combustion and conversion; technology of corrosion inhibitors; computers in corrosion control--modeling and information processing; recent experiences and advances of austenitic alloys; managing corrosion with plastics; corrosion measurement technology; corrosion inhibitors for concrete; refining industry; advances in corrosion control for rail and tank trailer equipment; CO{sub 2} corrosion--mechanisms and control; microbiologically influenced corrosion; corrosion in nuclear systems; role of corrosion in boiler failures; effects of water reuse on monitoring and control technology in cooling water applications; methods and mechanisms of scale and deposit control; corrosion detection in petroleum production lines; underground corrosion control; environmental cracking--relating laboratory results and field behavior; corrosion control in reinforced concrete structures; corrosion and its control in aerospace and military hardware; injection and process addition facilities; progress reports on the results of reinspection of deaerators inspected or repaired per RP0590 criteria; near 100% volume solids coating technology and application methods; materials performance in high temperature environments containing halides; impact of toxicity studies on use of corrosion/scale inhibitors; mineral scale deposit control in oilfield related operations; corrosion in gas treating; marine corrosion; cold climate corrosion; corrosion in the pulp and paper industry; gaseous chlorine alternatives in cooling water systems; practical applications of ozone in recirculating cooling water systems; and water reuse in industry. Over 400 papers from this conference have been processed separately for inclusion on the data base.

  17. Vaccination with Lipid Core Peptides Fails to Induce Epitope-Specific T Cell Responses but Confers Non-Specific Protective Immunity in a Malaria Model

    PubMed Central

    Apte, Simon H.; Groves, Penny L.; Skwarczynski, Mariusz; Fujita, Yoshio; Chang, Chenghung; Toth, Istvan; Doolan, Denise L.

    2012-01-01

    Vaccines against many pathogens for which conventional approaches have failed remain an unmet public health priority. Synthetic peptide-based vaccines offer an attractive alternative to whole protein and whole organism vaccines, particularly for complex pathogens that cause chronic infection. Previously, we have reported a promising lipid core peptide (LCP) vaccine delivery system that incorporates the antigen, carrier, and adjuvant in a single molecular entity. LCP vaccines have been used to deliver several peptide subunit-based vaccine candidates and induced high titre functional antibodies and protected against Group A streptococcus in mice. Herein, we have evaluated whether LCP constructs incorporating defined CD4+ and/or CD8+ T cell epitopes could induce epitope-specific T cell responses and protect against pathogen challenge in a rodent malaria model. We show that LCP vaccines failed to induce an expansion of antigen-specific CD8+ T cells following primary immunization or by boosting. We further demonstrated that the LCP vaccines induced a non-specific type 2 polarized cytokine response, rather than an epitope-specific canonical CD8+ T cell type 1 response. Cytotoxic responses of unknown specificity were also induced. These non-specific responses were able to protect against parasite challenge. These data demonstrate that vaccination with lipid core peptides fails to induce canonical epitope-specific T cell responses, at least in our rodent model, but can nonetheless confer non-specific protective immunity against Plasmodium parasite challenge. PMID:22936972

  18. District Leadership Conference Planner.

    ERIC Educational Resources Information Center

    Washington State Coordinating Council for Occupational Education, Olympia.

    This manual provides usable guidelines and planning forms and materials for planning district leadership conferences, which were designed and initiated in Washington State to meet the problems in student enrollment and, consequently, Distributive Education Clubs of America membership. The conferences have become a useful means to increase…

  19. [Conference Time Kit.

    ERIC Educational Resources Information Center

    National School Public Relations Association, Washington, DC.

    This multimedia kit, for use with and by teachers from kindergarten through the upper elementary grades, consists of four components: 1) a filmstrip for teachers; 2) the 1970 edition of a handbook, "Conference Time for Teachers and Parents"; 3) a filmstrip for parents; 4) a supporting parent information leaflet "How To Confer Successfully with…

  20. [Kweichow planned parenthood conference].

    PubMed

    1978-12-15

    On December 5th the Kweichow Provincial Planned Parenthood Leadership Group held its 1st conference to discuss the problems of planned parenthood in the province. Miao Chun-ting, deputy secretary of the provincial CCP committee and head of the provincial planned parenthood leadership group, presided over the conference.

  1. From Conference to Journal

    ERIC Educational Resources Information Center

    McCartney, Robert; Tenenberg, Josh

    2008-01-01

    Revising and extending conference articles for journal publication benefits both authors and readers. The new articles are more complete, and benefit from peer review, feedback from conference presentation, and greater editorial consistency. For those articles that are appropriate, we encourage authors to do this, and present two examples of such…

  2. The Conference in Retrospect.

    ERIC Educational Resources Information Center

    Gardner, Marjorie H.

    1982-01-01

    Presents an overview of the 6th International Conference on Chemical Education held at the University of Maryland (August 9-14, 1981), focusing on such organizational activities as roster building, people activating, innovative publishing, resolution and recommendation drafting, conference infrastructure and managerial mode, hospitality center,…

  3. The Learning Conference

    ERIC Educational Resources Information Center

    Ravn, Ib

    2007-01-01

    Purpose: The purpose of this paper is to call attention to the fact that conferences for professionals rely on massive one-way communication and hence produce little learning for delegates--and to introduce an alternative, the "learning conference", that involves delegates in fun and productive learning processes. Design/methodology/approach: A…

  4. ASE Annual Conference 2010

    ERIC Educational Resources Information Center

    McCune, Roger

    2010-01-01

    In this article, the author describes the ASE Annual Conference 2010 which was held at Nottingham after a gap of 22 years. As always, the main conference was preceded by International Day, an important event for science educators from across the world. There were two strands to the programme: (1) "What works for me?"--sharing new ideas and tried…

  5. Lyndon Johnson's Press Conferences.

    ERIC Educational Resources Information Center

    Cooper, Stephen

    Because President Lyndon Johnson understood well the publicity value of the American news media, he sought to exploit them. He saw reporters as "torch bearers" for his programs and policies and used the presidential press conference chiefly for promotional purposes. Although he met with reporters often, his press conferences were usually…

  6. The philosophy of modelling or does the philosophy of biology have any use?

    PubMed Central

    Orzack, Steven Hecht

    2012-01-01

    Biologists in search of answers to real-world issues such as the ecological consequences of global warming, the design of species' conservation plans, understanding landscape dynamics and understanding gene expression make decisions constantly that are based on a ‘philosophical’ stance as to how to create and test explanations of an observed phenomenon. For better or for worse, some kind of philosophy is an integral part of the doing of biology. Given this, it is more important than ever to undertake a practical assessment of what philosophy does mean and should mean to biologists. Here, I address three questions: should biologists pay any attention to ‘philosophy’; should biologists pay any attention to ‘philosophy of biology’; and should biologists pay any attention to the philosophy of biology literature on modelling? I describe why the last question is easily answered affirmatively, with the proviso that the practical benefits to be gained by biologists from this literature will be directly proportional to the extent to which biologists understand ‘philosophy’ to be a part of biology, not apart from biology. PMID:22144380

  7. Symmetrical kinematics does not imply symmetrical kinetics in people with transtibial amputation using cycling model.

    PubMed

    Childers, W Lee; Kogler, Géza F

    2014-01-01

    People with amputation move asymmetrically with regard to kinematics (joint angles) and kinetics (joint forces and moments). Clinicians have traditionally sought to minimize kinematic asymmetries, assuming kinetic asymmetries would also be minimized. A cycling model evaluated locomotor asymmetries. Eight individuals with unilateral transtibial amputation pedaled with 172 mm-length crank arms on both sides (control condition) and with the crank arm length shortened to 162 mm on the amputated side (CRANK condition). Pedaling kinetics and limb kinematics were recorded. Joint kinetics, joint angles (mean and range of motion [ROM]), and pedaling asymmetries were calculated from force pedals and with a motion capture system. A one-way analysis of variance with tukey post hoc compared kinetics and kinematics across limbs. Statistical significance was set to p does not relate to kinetic asymmetries as clinically assumed. We propose that future research should concentrate on defining acceptable asymmetry.

  8. Building technology transfer meetings: A collaborative model for transferring DOE research results to potential users

    SciTech Connect

    Shankle, D.L.; Hawkins, D.M.; Love, P.M.; Wilde, G.M.

    1994-08-01

    Transferring the technology and results from U.S. Department of Energy (DOE)-sponsored building energy research to potential users is a critical part of DOE`s successful research programs. To assist in this transfer of information and technologies, the DOE Office of Building Technologies (OBT) has established Building Technology Transfer Meetings that are held twice each year at one of the 10 DOE Regional Support Offices. Meeting participants include DOE personnel and representatives from each of the national laboratories involved in OBT buildings energy research as well as representatives from the DOE Regional Support Offices and other agencies involved in the buildings sector. Since 1991, OBT has held five meetings: Washington D.C., San Francisco, Denver, Oak Ridge, and Seattle. The purpose of these meetings is twofold: (1) for DOE to share information about such topics as new research results, new technologies, and new ways to collaborate with industry and universities to leverage resources; and (2) for the participants to use this information within their region to accelerate the transfer and deployment of new energy-efficient building technologies. The meetings include presentations, demonstrations, and tours. The meetings have provided an excellent opportunity for staff from the Regional Support Offices to learn about new technologies through their interactions with OBT and national laboratory program managers. Meeting tours and demonstrations have provided beneficial opportunities to get hands-on experience with new technologies and to see them in practice.

  9. Computational modeling of optogenetic neuronal excitation under complex illumination conditions using a Matlab-Neuron interface (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Yona, Guy; Weissler, Yonatan; Meitav, Nizan; Guzi, Eliran; Rifold, Dafna D.; Kahn, Itamar; Shoham, Shy

    2016-03-01

    Optogenetics has in recent years become a central tool in neuroscience research. Creating a realistic model of optogenetic neuronal excitation is of crucial importance for controlling the activation levels of various neuronal populations in different depths, predicting experimental results and designing the optical systems. However, current approaches to modeling light propagation through rodents' brain tissue suffer from major shortcomings and comprehensive modeling of local illumination levels together with other important factors governing excitation (i.e., cellular morphology, channel dynamics and expression), are still lacking. To address this challenge we introduce a new simulation tool for optogenetic neuronal excitation under complex and realistic illumination conditions that implements a detailed physical model for light scattering (in MATLAB) together with neuron morphology and channelrhodopsin-2 model (in NEURON). These two disparate simulation environments were interconnected using a newly developed generic interface termed 'NeuroLab'. Applying this method, we show that in a layer-V cortical neuron, the relative contribution of the apical dendrites to neuronal excitation is considerably greater than that of the soma or basal dendrites, when illuminated from the surface.

  10. 34 CFR 426.22 - What selection criteria does the Secretary use for the Program for Model Consumer and Homemaking...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What selection criteria does the Secretary use for the Program for Model Consumer and Homemaking Education Projects? 426.22 Section 426.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT...

  11. 34 CFR 426.22 - What selection criteria does the Secretary use for the Program for Model Consumer and Homemaking...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What selection criteria does the Secretary use for the Program for Model Consumer and Homemaking Education Projects? 426.22 Section 426.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT...

  12. 34 CFR 426.22 - What selection criteria does the Secretary use for the Program for Model Consumer and Homemaking...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false What selection criteria does the Secretary use for the Program for Model Consumer and Homemaking Education Projects? 426.22 Section 426.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT...

  13. "Does RE Work?" An Analysis of the Aims, Practices and Models of Effectiveness of Religious Education in the UK

    ERIC Educational Resources Information Center

    Lundie, David

    2010-01-01

    Possibly the largest qualitative study in RE policy and practice in many years, the AHRC/ESRC Religion and Society project "Does RE work? An analysis of the aims, practices and models of effectiveness in religious education in the UK", headed by the University of Glasgow, seeks to map the complex processes of curriculum formation as experienced in…

  14. Does Student Sorting Invalidate Value-Added Models of Teacher Effectiveness? An Extended Analysis of the Rothstein Critique

    ERIC Educational Resources Information Center

    Koedel, Cory; Betts, Julian R.

    2011-01-01

    Value-added modeling continues to gain traction as a tool for measuring teacher performance. However, recent research questions the validity of the value-added approach by showing that it does not mitigate student-teacher sorting bias (its presumed primary benefit). Our study explores this critique in more detail. Although we find that estimated…

  15. 40 CFR 60.1575 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false How does the model rule relate to the required elements of my State plan? 60.1575 Section 60.1575 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emission Guidelines and Compliance Times...

  16. Final Technical Report on DOE Grant for Modeling of Plasma Rotation in the National Spherical Torus Experiment

    SciTech Connect

    Shaing, K. C.

    2009-07-09

    This is the final technical report on the Modeling of Plasma Rotation in National Spherical Torus Experiment (NSTX) DOE Grant No. DE-FG02-02ER54679. The research subjects, technical abstracts, and publications where details of the research results can be found are reported here.

  17. Liquid in the gastroesophageal segment promotes reflux, but compliance does not: a mathematical modeling study

    PubMed Central

    Ghosh, Sudip K.; Kahrilas, Peter J.; Brasseur, James G.

    2008-01-01

    The mechanical force relationships that distinguish normal from chronic reflux at sphincter opening are poorly understood and difficult to measure in vivo. Our aim was to apply physics-based computer simulations to determine mechanical pathogenesis of gastroesophageal reflux. A mathematical model of the gastroesophageal segment (GES) was developed, incorporating the primary anatomical and physiomechanical elements that drive GES opening and reflux. In vivo data were used to quantify muscle stiffness, sphincter tone, and gastric pressure. The liquid lining the mucosa was modeled as an “effective liquid film” between the mucosa and a manometric catheter. Newton's second law was solved mathematically, and the space-time details of opening and reflux were predicted for systematic variations in gastric pressure increase, film thickness, muscle stiffness, and tone. “Reflux” was defined as “2 ml of refluxate entering the esophagus within 1 s.” GES opening and reflux were different events. Both were sensitive to changes in gastric pressure and sphincter tone. Reflux initiation was extremely sensitive to the liquid film thickness; the protective function of the sphincter was destroyed with only 0.4 mm of liquid in the GES. Compliance had no effect on reflux initiation, but affected reflux volume. The presence of abnormal levels of liquid within the collapsed GES can greatly increase the probability for reflux, suggesting a mechanical mechanism that may differentiate normal reflux from gastroesophageal reflux disease. Compliance does not affect the probability for reflux, but affects reflux volume once it occurs. Opening without reflux suggests the existence of “gastroesophageal pooling” in the distal esophagus, with clinical implications. PMID:18718998

  18. Liquid in the gastroesophageal segment promotes reflux, but compliance does not: a mathematical modeling study.

    PubMed

    Ghosh, Sudip K; Kahrilas, Peter J; Brasseur, James G

    2008-11-01

    The mechanical force relationships that distinguish normal from chronic reflux at sphincter opening are poorly understood and difficult to measure in vivo. Our aim was to apply physics-based computer simulations to determine mechanical pathogenesis of gastroesophageal reflux. A mathematical model of the gastroesophageal segment (GES) was developed, incorporating the primary anatomical and physiomechanical elements that drive GES opening and reflux. In vivo data were used to quantify muscle stiffness, sphincter tone, and gastric pressure. The liquid lining the mucosa was modeled as an "effective liquid film" between the mucosa and a manometric catheter. Newton's second law was solved mathematically, and the space-time details of opening and reflux were predicted for systematic variations in gastric pressure increase, film thickness, muscle stiffness, and tone. "Reflux" was defined as "2 ml of refluxate entering the esophagus within 1 s." GES opening and reflux were different events. Both were sensitive to changes in gastric pressure and sphincter tone. Reflux initiation was extremely sensitive to the liquid film thickness; the protective function of the sphincter was destroyed with only 0.4 mm of liquid in the GES. Compliance had no effect on reflux initiation, but affected reflux volume. The presence of abnormal levels of liquid within the collapsed GES can greatly increase the probability for reflux, suggesting a mechanical mechanism that may differentiate normal reflux from gastroesophageal reflux disease. Compliance does not affect the probability for reflux, but affects reflux volume once it occurs. Opening without reflux suggests the existence of "gastroesophageal pooling" in the distal esophagus, with clinical implications.

  19. Transportable Applications Environment (TAE) Tenth Users' Conference

    NASA Technical Reports Server (NTRS)

    Rouff, Chris (Editor); Harris, Elfrieda (Editor); Yeager, Arleen (Editor)

    1993-01-01

    Conference proceedings are represented in graphic visual-aid form. Presentation and panel discussion topics include user experiences with C++ and Ada; the design and interaction of the user interface; the history and goals of TAE; commercialization and testing of TAE Plus; Computer-Human Interaction Models (CHIMES); data driven objects; item-to-item connections and object dependencies; and integration with other software. There follows a list of conference attendees.

  20. ConfChem Conference on Flipped Classroom: Improving Student Engagement in Organic Chemistry Using the Inverted Classroom Model

    ERIC Educational Resources Information Center

    Rossi, Robert D.

    2015-01-01

    Improving student engagement in STEM (science, technology, engineering, and mathematics) courses generally, and organic chemistry specifically, has long been a goal for educators. Recently educators at all academic levels have been exploring the "inverted classroom" or "flipped classroom" pedagogical model for improving student…

  1. 17th International Conference on Arabidopsis Research

    SciTech Connect

    Judith Bender

    2006-07-01

    The 17th International Conference on Arabidopsis Research was held at the University of Madison, Wisconsin from June 27- July 2, 2006. ICAR-2006 included approximately 625 scientists from across the world. The scientific program was of excellent quality featuring 73 talks, including 30 from invited speakers. There were also 6 community-organized workshops (facilitated by conference staff) featuring additional talks on topics including ‘Submitting data to long-term repositories,’ ‘TAIR introductory workshop,’ ‘Web services and demonstration,’ ‘Public engagement: broadening the impact of your research,’ ‘Systems biology approaches to analysis of metabolic and regulatory networks of Arabidopsis,’ and ‘Mechanotransduction in Arabidopsis.’ Approximately 440 posters were presented in general topic areas including, among others, Development, Modeling/Other Systems, Energy, Environment, and Genetic/Epigenetic mechanisms. Graduate students, postdoctoral researchers, junior faculty, and underrepresented minorities made up a significant portion of the oral presentations thereby promoting the training of young scientists and facilitating important career development opportunities for speakers. Several poster sessions provided an opportunity for younger participants to freely meet with more established scientists. The North American Arabidopsis Steering Committee (NAASC) continued its outreach effort and again sponsored two special luncheons to encourage personal and professional development of young scientists and also underrepresented minorities. The ‘Emerging Scientists Luncheon’ featured 10 graduate students selected on the basis of scientific excellence of their submitted research abstracts. The ‘Minority Funding Luncheon,’ featured 8 awardees selected by the NAASC through a widely-publicized application process. This luncheon was established specifically to provide an opportunity for underrepresented minorities, and/or scientists from

  2. CONFERENCE NOTE: Conference on Precision Electromagnetic Measurements

    NASA Astrophysics Data System (ADS)

    1991-01-01

    The next Conference on Precision Electromagnetic Measurements (CPEM), will be held from 9 to 12 June 1992 at the Centre des Nouvelles Industries et Technologies (CNIT), La Défense, Paris, France. This conference, which is held every two years and whose importance and high level, confirmed by thirty years' experience, are recognized throughout the world, can be considered as a forum in which scientists, metrologists and professionals will have the opportunity to present and compare their research results on fundamental constants, standards and new techniques of precision measurement in the electromagnetic domain. Topics The following topics are regarded as the most appropriate for this conference: realization of units and fundamental constants d.c. a.c. and high voltage time and frequency radio-frequency and microwaves dielectrics, antennas, fields lasers, fibre optics advanced instrumentation, cryoelectronics. There will also be a session on international cooperation. Conference Language The conference language will be English. No translation will be provided. Organizers Société des Electriciens et des Electroniciens (SEE). Bureau National de Métrologie (BNM) Sponsors Institute of Electrical and Electronics Engineers (IEEE) Instrumentation & Measurement Society Union Radio Scientifique Internationale United States National Institute of Standards and Technology Centre National d'Etudes des Télécommunications Mouvement Français pour la Qualité, Section Métrologie Comité National Français de Radioélectricité Scientifique Contact Jean Zara, CPEM 92 publicity, Bureau National de Métrologie, 22, rue Monge, 75005 Paris Tel.: (33) 1 46 34 48 16, Fax: (33) 1 46 34 48 63

  3. ISMB Conference Proceedings

    SciTech Connect

    Teresa, Gaasterand; Martin, Vingron

    2011-07-01

    This special issue comprises the papers accepted for presentation at the 19th Annual International Conference on Intelligent Systems for Molecular Biology, joint with the 10th European Conference on Computational Biology, an official conference of the International Society for Computational Biology (ISCB; http://www.iscb.org). ISMB/ECCB 2011 (http://www.iscb.org/ismb2011/) will take place in Vienna, Austria, from July 17 through July 19, 2011; preceded during July 14–16 by eight 1- or 2- day Special Interest Group (SIG) meetings, three satellite meetings and nine half-day tutorials; and followed by two additional satellite meetings. The 48 papers in this volume were selected from 258 submitted papers. Submitted papers were assigned to 13 areas. Area Chairs led each topic area by selecting their area's program committee and overseeing the reviewing process. Many Area Chairs were new compared to 2010, and two completely new areas were added in 2011, ‘Data Visualization’ and ‘Mass Spectrometry and Proteomics’. Six papers for which Area Chairs were in conflict were reviewed under a ‘Conflicts Management’ section headed by the Proceedings Chairs; one such paper was accepted in ‘Bioimaging’. Areas, co-chairs and acceptance information are listed in Table 1. Compared to prior years, five mature topic areas had steady submissions, ‘Evolution and Comparative Genomics’, ‘Gene Regulation and Transcriptomics’, ‘Protein Structure and Function’, ‘Sequence Analysis’, ‘Text Mining’. Two areas newer to ISMB were underrepresented this year, ‘Bioimaging’ and ‘Disease Models and Epidemiology’. One area doubled, ‘Applied Bioinformatics’, renamed from last year's ‘Other Bioinformatics Applications’; and one tripled, ‘Protein Interactions and Molecular Networks’. Across the areas, 326 members of the bioinformatics community provided reviews. Most papers received three reviews and several received four or more. There was

  4. Oceans '86 conference record

    SciTech Connect

    Not Available

    1986-01-01

    These five volumes represent the proceedings of the Oceans '86 Conference Washington, DC, 23-25 September 1986. Volume 1 includes papers on Underwater Photography and Sensing; Marine Recreation; Diving; CTACTS (Charleston Tactical Aircrew Combat Training System); Offshore and Coastal Structures; Underwater Welding, Burning and Cutting; Advances in Ocean Mapping; Ocean Energy; Biofouling and Corrosion; Moorings, Cables and Connections; Marine Minerals; Remote Sensing and Satellites; and Acoustics Analysis. Volume 2 covers Data Base Management; Modeling and Simulation; Ocean Current Simulation; Instrumentation; Artificial Reefs and Fisheries; US Status and Trends; Education and Technology Transfer; Economic Potential and Coastal Zone Management; and Water Quality. Volume 3 includes papers on National and Regional Monitoring Strategies; New Techniques and Strategies for Monitoring; Indicator Parameters/Organisms; Historical Data; Crystal Cube for Coastal and Estuarine Degradation; and the Monitoring Gap. Volume 4 covers the Organotin Symposium - Chemistry; Toxicity Studies; and Environmental Monitoring and Modeling. Volume 5 includes papers on Advances in Oceanography; Applied Oceanography; Unmanned Vehicles and ROV's; Manned Vehicles; and Oceanographic Ships.

  5. The DOE Model for Improving Seismic Event Locations Using Travel Time Corrections: Description and Demonstration

    SciTech Connect

    Hipp, J.R.; Moore, S.G.; Shepherd, E.; Young, C.J.

    1998-10-20

    The U.S. National Laboratories, under the auspices of the Department of Energy, have been tasked with improv- ing the capability of the United States National Data Center (USNDC) to monitor compliance with the Comprehen- sive Test Ban Trea~ (CTBT). One of the most important services which the USNDC must provide is to locate suspicious events, preferably as accurately as possible to help identify their origin and to insure the success of on-site inspections if they are deemed necessary. The seismic location algorithm used by the USNDC has the capability to generate accurate locations by applying geographically dependent travel time corrections, but to date, none of the means, proposed for generating and representing these corrections has proven to be entirely satisfactory. In this presentation, we detail the complete DOE model for how regional calibration travel time information gathered by the National Labs will be used to improve event locations and provide more realistic location error esti- mates. We begin with residual data and error estimates from ground truth events. Our model consists of three parts: data processing, data storage, and data retrieval. The former two are effectively one-time processes, executed in advance before the system is made operational. The last step is required every time an accurate event location is needed. Data processing involves applying non-stationary Bayesian kriging to the residwd data to densifi them, and iterating to find the optimal tessellation representation for the fast interpolation in the data retrieval task. Both the kriging and the iterative re-tessellation are slow, computationally-expensive processes but this is acceptable because they are performed off-line, before any events are to be located. In the data storage task, the densified data set is stored in a database and spatially indexed. Spatial indexing improves the access efficiency of the geographically-ori- ented data requests associated with event location

  6. Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis.

    PubMed

    Lu, Ming; Yang, Jing-Zhe; Geng, Fan; Ding, Jian-Hua; Hu, Gang

    2014-09-01

    Depression is a serious mental disorder in the world, but the underlying mechanisms remain unclear and the effective cures are scarce. Iptakalim (Ipt), an ATP-sensitive potassium (K-ATP) channel opener that can cross the blood-brain barrier freely, has been demonstrated to inhibit neuro-inflammation and enhance adult hippocampal neurogenesis. But it is unknown whether Ipt is beneficial to therapy of depression by modulating neurogenesis and neuro-inflammation. This study aimed to determine the potential antidepressant efficacy of Ipt in a chronic mild stress (CMS) mouse model of depression. We showed that treatment with Ipt (10 mg/kg/day, i.p) for 4 wk restored the decrease of sucrose preference and shortened the immobile time in forced swimming tests (FST) and tail suspension tests (TST) in CMS model mice. We further found that Ipt reversed the CMS-induced reduction of the adult hippocampal neurogenesis and improved cerebral insulin signalling in the CMS mice. Furthermore, Ipt negatively regulated nod-like receptor protein 3 (NLRP3) expression and, in turn, inhibited microglia-mediated neuro-inflammation by suppressing the activation of NLRP3-inflammasome/caspase-1/interleukin 1β axis in the hippocampus of CMS mice. Taken together, our findings demonstrate that Ipt plays a potential antidepressant role in CMS model mice through regulating neuro-inflammation and neurogenesis, which will provide potential for Ipt in terms of opening up novel therapeutic avenues for depression.

  7. Cloud-based Monte Carlo modelling of BSSRDF for the rendering of human skin appearance (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Doronin, Alexander; Rushmeier, Holly E.; Meglinski, Igor; Bykov, Alexander V.

    2016-03-01

    We present a new Monte Carlo based approach for the modelling of Bidirectional Scattering-Surface Reflectance Distribution Function (BSSRDF) for accurate rendering of human skin appearance. The variations of both skin tissues structure and the major chromophores are taken into account correspondingly to the different ethnic and age groups. The computational solution utilizes HTML5, accelerated by the graphics processing units (GPUs), and therefore is convenient for the practical use at the most of modern computer-based devices and operating systems. The results of imitation of human skin reflectance spectra, corresponding skin colours and examples of 3D faces rendering are presented and compared with the results of phantom studies.

  8. [Preliminary evaluation of Chile's First Citizen Consensus Conference].

    PubMed

    Pellegrini Filho, Alberto; Zurita, Laura

    2004-05-01

    This piece provides an initial assessment of the First Citizen Consensus Conference, an event held in the city of Santiago, Chile, from 22-24 November 2003, on the subject of "The Management of My Medical Record." This conference was the first citizen consensus conference that has been held in Chile as well as the first such conference in Latin America. Consensus conferences were devised by the Danish Board of Technology in 1987 as a way to assess science and technology issues through discussions between experts and a panel of lay persons. At the end of a consensus conference, the lay persons express their opinions and recommendations in a consensus report that is directed at policymakers, decision-makers, and the public in general. The objective of a consensus conference is to bridge the gaps that routinely exist among the general public, experts, and elected officials. So far, the Danish Board of Technology has organized more than 20 of these conferences, using a methodology that has become established as a model. Taking into account the changes that have occurred in the relationship between science and society at large, the Pan American Health Organization has decided to support the holding of consensus conferences in Latin America and the Caribbean. The First Citizen Consensus Conference adapted the Danish methodology to conditions in Chile, and this piece assesses the modifications that were made. In addition, some 6 to 12 months after the conference, there will be an external evaluation of the outcomes and impact of the conference, especially in the communications media, public debate, decision-making, and perceptions of the persons who were involved. Despite the criticisms made in this piece and some shortcomings that are pointed out, the First Citizen Consensus Conference achieved all of its objectives and will serve as an excellent model for similar conferences in other countries of the Americas. PMID:15231085

  9. [Preliminary evaluation of Chile's First Citizen Consensus Conference].

    PubMed

    Pellegrini Filho, Alberto; Zurita, Laura

    2004-05-01

    This piece provides an initial assessment of the First Citizen Consensus Conference, an event held in the city of Santiago, Chile, from 22-24 November 2003, on the subject of "The Management of My Medical Record." This conference was the first citizen consensus conference that has been held in Chile as well as the first such conference in Latin America. Consensus conferences were devised by the Danish Board of Technology in 1987 as a way to assess science and technology issues through discussions between experts and a panel of lay persons. At the end of a consensus conference, the lay persons express their opinions and recommendations in a consensus report that is directed at policymakers, decision-makers, and the public in general. The objective of a consensus conference is to bridge the gaps that routinely exist among the general public, experts, and elected officials. So far, the Danish Board of Technology has organized more than 20 of these conferences, using a methodology that has become established as a model. Taking into account the changes that have occurred in the relationship between science and society at large, the Pan American Health Organization has decided to support the holding of consensus conferences in Latin America and the Caribbean. The First Citizen Consensus Conference adapted the Danish methodology to conditions in Chile, and this piece assesses the modifications that were made. In addition, some 6 to 12 months after the conference, there will be an external evaluation of the outcomes and impact of the conference, especially in the communications media, public debate, decision-making, and perceptions of the persons who were involved. Despite the criticisms made in this piece and some shortcomings that are pointed out, the First Citizen Consensus Conference achieved all of its objectives and will serve as an excellent model for similar conferences in other countries of the Americas.

  10. Increase in visceral fat per se does not induce insulin resistance in the canine model

    PubMed Central

    Castro, Ana V.B.; Woolcott, Orison O.; Iyer, Malini S.; Kabir, Morvarid; Ionut, Viorica; Stefanovski, Darko; Kolka, Cathryn M.; Szczepaniak, Lidia S.; Szczepaniak, Edward W.; Asare-Bediako, Isaac; Paszkiewicz, Rebecca L.; Broussard, Josiane L.; Kim, Stella P.; Kirkman, Erlinda L.; Rios, Hernan C.; Mkrtchyan, Hasmik; Wu, Qiang; Ader, Marilyn; Bergman, Richard N.

    2014-01-01

    Objective To determine whether a selective increase of visceral adipose tissue content will result in insulin resistance. Design and Methods Sympathetic denervation of the omental fat was performed under general inhalant anesthesia by injecting 6-hydroxydopamine in the omental fat of lean mongrel dogs (n=11). In the conscious animal, whole-body insulin sensitivity was assessed by the minimal model (SI) and the euglycemic hyperinsulinemic clamp (SICLAMP). Changes in abdominal fat were monitored by magnetic resonance. All assessments were determined before (Wk0) and 2 weeks (Wk2) after denervation. Data are medians (upper and lower interquartile). Results Denervation of omental fat resulted in increased percentage (and content) of visceral fat [Wk0: 10.2% (8.5−11.4); Wk2: 12.4% (10.4−13.6); P<0.01]. Abdominal subcutaneous fat remained unchanged. However, we found no changes in SI [Wk0: 4.7 (mU/L)−1•min−1 (3.1−8.8); Wk2: 5.3 (mU/L)−1•min−1 (4.5−7.2); P=0.59] or SICLAMP [Wk0: 42.0 ×10.4 dL•kg−1•min−1•(mU/L)−1 (41.0−51.0); Wk2: 40.0 ×10.4 dL•kg−1•min−1•(mU/L)−1 (34.0−52.0); P=0.67]. Conclusions Despite a selective increase in visceral adiposity in dogs, insulin sensitivityin vivo does not change, which argues against the concept that accumulation of visceral adipose tissue contributes to insulin resistance. PMID:25322680

  11. 47 CFR 1.248 - Prehearing conferences; hearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Prehearing conferences; hearing conferences. 1.248 Section 1.248 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Hearing Proceedings Prehearing Procedures § 1.248 Prehearing conferences; hearing conferences. (a)...

  12. Respiratory and oral vaccination improves protection conferred by the live vaccine strain against pneumonic tularemia in the rabbit model.

    PubMed

    Stinson, Elizabeth; Smith, Le'Kneitah P; Cole, Kelly Stefano; Barry, Eileen M; Reed, Douglas S

    2016-10-01

    Tularemia is a severe, zoonotic disease caused by a gram-negative bacterium, Francisella tularensis We have previously shown that rabbits are a good model of human pneumonic tularemia when exposed to aerosols containing a virulent, type A strain, SCHU S4. We further demonstrated that the live vaccine strain (LVS), an attenuated type B strain, extended time to death when given by scarification. Oral or aerosol vaccination has been previously shown in humans to offer superior protection to parenteral vaccination against respiratory tularemia challenge. Both oral and aerosol vaccination with LVS were well tolerated in the rabbit with only minimal fever and no weight loss after inoculation. Plasma antibody titers against F. tularensis were higher in rabbits that were vaccinated by either oral or aerosol routes compared to scarification. Thirty days after vaccination, all rabbits were challenged with aerosolized SCHU S4. LVS given by scarification extended time to death compared to mock-vaccinated controls. One orally vaccinated rabbit did survive aerosol challenge, however, only aerosol vaccination extended time to death significantly compared to scarification. These results further demonstrate the utility of the rabbit model of pneumonic tularemia in replicating what has been reported in humans and macaques as well as demonstrating the utility of vaccination by oral and respiratory routes against an aerosol tularemia challenge. PMID:27511964

  13. Respiratory and oral vaccination improves protection conferred by the live vaccine strain against pneumonic tularemia in the rabbit model.

    PubMed

    Stinson, Elizabeth; Smith, Le'Kneitah P; Cole, Kelly Stefano; Barry, Eileen M; Reed, Douglas S

    2016-10-01

    Tularemia is a severe, zoonotic disease caused by a gram-negative bacterium, Francisella tularensis We have previously shown that rabbits are a good model of human pneumonic tularemia when exposed to aerosols containing a virulent, type A strain, SCHU S4. We further demonstrated that the live vaccine strain (LVS), an attenuated type B strain, extended time to death when given by scarification. Oral or aerosol vaccination has been previously shown in humans to offer superior protection to parenteral vaccination against respiratory tularemia challenge. Both oral and aerosol vaccination with LVS were well tolerated in the rabbit with only minimal fever and no weight loss after inoculation. Plasma antibody titers against F. tularensis were higher in rabbits that were vaccinated by either oral or aerosol routes compared to scarification. Thirty days after vaccination, all rabbits were challenged with aerosolized SCHU S4. LVS given by scarification extended time to death compared to mock-vaccinated controls. One orally vaccinated rabbit did survive aerosol challenge, however, only aerosol vaccination extended time to death significantly compared to scarification. These results further demonstrate the utility of the rabbit model of pneumonic tularemia in replicating what has been reported in humans and macaques as well as demonstrating the utility of vaccination by oral and respiratory routes against an aerosol tularemia challenge.

  14. Views from the 1995 ECC conference

    SciTech Connect

    Lowry, J.C.; Haegelin, J.K.; Underwood, J.K.

    1995-12-01

    The Engineering and Construction Contracting Division (ECC) of the AIChE held its 27th Annual Conference in Scottsdale, Arizona, Sept. 7--8, 1995. Each year the conference is attended by management representatives from manufacturers, producers, engineering and construction contractors, consultants and major equipment suppliers. The 1995 conference theme was, Applying Advanced Methodology to Improve Project Execution. What were the issues and recommendations resulting from the conference? Here are the composite results from the annual workshops, as well as some perspectives from three selected participants. The paper discusses modularization in the process industry, innovative construction practices, creation and use of 3-D models for the plant`s life cycle, alliances and pay-for-performance contracting, and new workshop formats, and ends with general views from selected participants.

  15. Mouse Model of OPRM1 (A118G) Polymorphism Increases Sociability and Dominance and Confers Resilience to Social Defeat

    PubMed Central

    Briand, Lisa A.; Hilario, Monica; Dow, Holly C.; Brodkin, Edward S.; Berton, Olivier

    2015-01-01

    A single nucleotide polymorphism (SNP) in the human μ-opioid receptor gene (OPRM1 A118G) has been widely studied for its association in drug addiction, pain sensitivity, and, more recently, social behavior. The endogenous opioid system has been shown to regulate social distress and reward in a variety of animal models. However, mechanisms underlying the associations between the OPRM1 A118G SNP and these behaviors have not been clarified. We used a mouse model possessing the human equivalent nucleotide/amino acid substitution to study social affiliation and social defeat behaviors. In mice with the Oprm1 A112G SNP, we demonstrate that the G allele is associated with an increase in home-cage dominance and increased motivation for nonaggressive social interactions, similar to what is reported in human populations. When challenged by a resident aggressor, G-allele carriers expressed less submissive behavior and exhibited resilience to social defeat, demonstrated by a lack of subsequent social avoidance and reductions in anhedonia as measured by intracranial self-stimulation. Protection from social defeat in G-allele carriers was associated with a greater induction of c-fos in a resilience circuit comprising the nucleus accumbens and periaqueductal gray. These findings led us to test the role of endogenous opioids in the A112G mice. We demonstrate that the increase in social affiliation in G carriers is blocked by pretreatment with naloxone. Together, these data suggest a mechanism involving altered hedonic state and neural activation as well as altered endogenous opioid tone in the differential response to aversive and rewarding social stimuli in G-allele carriers. PMID:25716856

  16. Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model

    PubMed Central

    Maltsev, Victor A.; Lakatta, Edward G.

    2009-01-01

    Recent experimental studies have demonstrated that sinoatrial node cells (SANC) generate spontaneous, rhythmic, local subsarcolemmal Ca2+ releases (Ca2+ clock), which occur during late diastolic depolarization (DD) and interact with the classic sarcolemmal voltage oscillator (membrane clock) by activating Na+-Ca2+ exchanger current (INCX). This and other interactions between clocks, however, are not captured by existing essentially membrane-delimited cardiac pacemaker cell numerical models. Using wide-scale parametric analysis of classic formulations of membrane clock and Ca2+ cycling, we have constructed and initially explored a prototype rabbit SANC model featuring both clocks. Our coupled oscillator system exhibits greater robustness and flexibility than membrane clock operating alone. Rhythmic spontaneous Ca2+ releases of sarcoplasmic reticulum (SR)-based Ca2+ clock ignite rhythmic action potentials via late DD INCX over much broader ranges of membrane clock parameters [e.g., L-type Ca2+ current (ICaL) and/or hyperpolarization-activated (“funny”) current (If) conductances]. The system Ca2+ clock includes SR and sarcolemmal Ca2+ fluxes, which optimize cell Ca2+ balance to increase amplitudes of both SR Ca2+ release and late DD INCX as SR Ca2+ pumping rate increases, resulting in a broad pacemaker rate modulation (1.8–4.6 Hz). In contrast, the rate modulation range via membrane clock parameters is substantially smaller when Ca2+ clock is unchanged or lacking. When Ca2+ clock is disabled, the system parametric space for fail-safe SANC operation considerably shrinks: without rhythmic late DD INCX ignition signals membrane clock substantially slows, becomes dysrhythmic, or halts. In conclusion, the Ca2+ clock is a new critical dimension in SANC function. A synergism of the coupled function of Ca2+ and membrane clocks confers fail-safe SANC operation at greatly varying rates. PMID:19136600

  17. Does the Core Contain Potassium?: An Assessment of the Uncertainties in Thermal and Dynamo Evolution Models

    NASA Astrophysics Data System (ADS)

    Nimmo, F.

    2006-12-01

    The long-term thermal evolution of the core, and the history of the geodynamo, are determined by the rate at which heat is extracted from the core, and the presence of any heat sources within the core [1,2]. Radioactive potassium may provide one such heat source: mineral physics results [3,4] are permissive but not definitive; cosmochemical constraints are weak [5]; and geoneutrino detection [6] does not yet have the required resolution. Theoretical models [1-2,7-9] can help to address whether or not potassium is present in the core. Since the evolution of the CMB heat flux is hard to calculate, a better approach is to assume that the entropy available to power the geodynamo has remained constant over time, and to infer the resulting heat flux [2]. Unfortunately, several important parameters, notably core thermal conductivity and the entropy production rate required to sustain the geodynamo, are uncertain. I have carried out a suite of models using a wide range of parameter values based on published results. In the absence of potassium, an ancient inner core [10] and a continuously active geodynamo are only possible if 1) the dissipation generated by the dynamo is small, <0.25 TW 2) the CMB heat flux has stayed constant at ~ 4 TW for the whole of Earth history. The latter condition is in conflict with recent estimates of the present-day CMB heat flux of 10± 4 TW [11,12]. An ancient inner core, if correct, appears to require the presence of 100 ppm potassium in the core. [1] Buffett, GRL 29, 1566, 2002. [2] Labrosse, PEPI 140, 127-143, 2003. [3] Lee et al., GRL 31, L11603, 2004. [4] Gessmann and Wood, EPSL 200, 63-78, 2002. [5] Lassiter G3, Q11012, 2004. [6] Araki et al., Nature 436, 499-503, 2005. [7] Lister PEPI 140, 145-158, 2003. [8] Roberts et al., in Earth's Core and Lower Mantle, ed. Jones et al. [9] Nimmo et al. GJI 156, 363-376, 2004. [10] Brandon et al., EPSL 206, 411-426, 2003. [11] Hernlund et al., Nature 434, 882-886, 2005. [12] Zhong, JGR 111, B04409

  18. Aircraft Engine Emissions. [conference

    NASA Technical Reports Server (NTRS)

    1977-01-01

    A conference on a aircraft engine emissions was held to present the results of recent and current work. Such diverse areas as components, controls, energy efficient engine designs, and noise and pollution reduction are discussed.

  19. Conference Summary Final Remarks

    NASA Astrophysics Data System (ADS)

    Greiner, Walter

    2007-05-01

    Finally we come to the last talk. The end of the Conference is near! I try to reflect on an interesting Conference, with many different - diverse - topics and 5 parallel afternoon sessions. How to solve this difficulty? I do it my way and present a selection of what I personally found interesting. I illustrate these topics with the help of slides which are borrowed from various speakers at the conference. There are outstanding problems, which will also find attention and interest if explained to non-nuclear physicists, common people. I will address four such topics which were were discussed at this conference: Heavy-Ion Cancer Therapy Extension of the Periodic Table - Superheavy Elements Nuclear Astrophysics Hot compressed elementary matter - Production - Phases

  20. DNA sequencing conference, 2

    SciTech Connect

    Cook-Deegan, R.M.; Venter, J.C.; Gilbert, W.; Mulligan, J.; Mansfield, B.K.

    1991-06-19

    This conference focused on DNA sequencing, genetic linkage mapping, physical mapping, informatics and bioethics. Several were used to study this sequencing and mapping. This article also discusses computer hardware and software aiding in the mapping of genes.

  1. Lunar & Planetary Science Conference.

    ERIC Educational Resources Information Center

    Warner, Jeffrey L.; And Others

    1982-01-01

    Summaries of different topics discussed at the Lunar and Planetary Science Conference are presented to provide updated information to nonplanetologists. Some topics include Venus, isotopes, chondrites, creation science, cosmic dust, cratering, moons and rings, igneous rocks, and lunar soil. (DC)

  2. Botulinum Neurotoxin Type A Subtype 2 Confers Greater Safety than Subtype 1 in a Rat Parkinson’s Disease Model

    PubMed Central

    ITAKURA, Masanori; KOHDA, Tomoko; KUBO, Takeya; SEMI, Yuko; NISHIYAMA, Kazuhiro; AZUMA, Yasu-Taka; NAKAJIMA, Hidemitsu; KOZAKI, Shunji; TAKEUCHI, Tadayoshi

    2014-01-01

    ABSTRACT Botulinum neurotoxin type A (BoNT/A) cleaves SNAP-25 and interrupts the release of acetylcholine. We previously reported that BoNT/A subtype 2 (BoNT/A2) ameliorates pathologic behavior more effectively than subtype 1 (BoNT/A1) in a rat Parkinson’s disease model. Here, we further show BoNT/A2 has fewer adverse effects than BoNT/A1. We first confirmed that intrastriatal treatments of both BoNT/As had no-effect on dopaminergic terminals in the striatum. SNAP-25 cleaved by BoNT/A2 was strictly localized to the striatum on the injected side; however, SNAP-25 cleaved by BoNT/A1 diffused contralaterally. Furthermore, treatment with BoNT/A1 caused a significant reduction in body weight, while BoNT/A2 treatment did not. These results suggest that BoNT/A2 is more beneficial for clinical application against Parkinson’s disease than BoNT/A1. PMID:24849052

  3. Multiphoton processes: conference proceedings

    SciTech Connect

    Lambropoulos, P.; Smith, S.J.

    1984-01-01

    The chapters of this volume represent the invited papers delivered at the conference. They are arranged according to thermatic proximity beginning with atoms and continuing with molecules and surfaces. Section headings include multiphoton processes in atoms, field fluctuations and collisions in multiphoton process, and multiphoton processes in molecules and surfaces. Abstracts of individual items from the conference were prepared separately for the data base. (GHT)

  4. Women and the Cairo conference.

    PubMed

    Kaufman, E

    1994-09-01

    The UN Population Conference in Cairo again turns my thoughts to the plight of women, especially in the underdeveloped countries. Women of all ages who even in this supposedly enlightened time don't have the right even to question or hope, much less a choice. Conference participants will be addressing the status of women, a contributing factor to population growth. Hopefully with courage and determination they will bring about an improvement in the lives of women. With the number of people reaching 6 billion, conditions can only get worse. Life in many areas has already become cheap and expendable. The unwanted street children of Brazil are just one example. Access to counseling and contraception would help women control the number of children they want and can care for. Unfortunately the Vatican has encouraged a coalition with the Islamic fundamentalists in an effort to undermine the reproductive health provisions. This alliance can only see "abortion, abortion" as its members eulogize the reverence for life. Considering half a million women die each year from pregnancy causes and botched abortions, one must question the validity of their passion. I hope I live long enough to see the church admit that there is a limit to the number of children a family can care for and that God does not always provide. What the Vatican chooses to call "abortion on demand," a clever, negative term used to imply arrogance, is most often who gets food and who doesn't.

  5. Conference scene: DGVS spring conference 2009.

    PubMed

    Kolligs, Frank Thomas

    2009-10-01

    The 3rd annual DGVS Spring Conference of the German Society for Gastroenterology (Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten) was held at the Seminaris Campus Hotel in Berlin, Germany, on 8-9 May, 2009. The conference was organized by Roland Schmid and Matthias Ebert from the Technical University of Munich, Germany. The central theme of the meeting was 'translational gastrointestinal oncology: towards personalized medicine and individualized therapy'. The conference covered talks on markers for diagnosis, screening and surveillance of colorectal cancer, targets for molecular therapy, response prediction in clinical oncology, development and integration of molecular imaging in gastrointestinal oncology and translational research in clinical trial design. Owing to the broad array of topics and limitations of space, this article will focus on biomarkers, response prediction and the integration of biomarkers into clinical trials. Presentations mentioned in this summary were given by Matthias Ebert (Technical University of Munich, Germany), Esmeralda Heiden (Epigenomics, Berlin, Germany), Frank Kolligs (University of Munich, Germany), Florian Lordick (University of Heidelberg, Germany), Hans Jorgen Nielsen (University of Copenhagen, Denmark), Anke Reinacher-Schick (University of Bochum, Germany), Christoph Röcken (University of Berlin, Germany), Wolff Schmiegel (University of Bochum, Germany) and Thomas Seufferlein (University of Halle, Germany).

  6. Strain dependent protection conferred by Lactobacillus spp. administered orally with a Salmonella Typhimurium vaccine in a murine challenge model.

    PubMed

    Esvaran, M; Conway, P L

    2012-03-30

    Consumption of Lactobacillus spp. has been shown to enhance immune responses in mice. This study examined the immuno-adjuvant capacity of two strains: Lactobacillus acidophilus L10 and Lactobacillus fermentum PC2, in the induction of protective humoral immunity in a Salmonella Typhimurium vaccine challenge model. Briefly, BALB/c mice were divided into four groups. Three groups of mice received S. Typhimurium vaccine (10(8) colony forming units (CFU) per dose) on days 0 and 14. In addition to the vaccine, five doses (10(8) CFU per dose) of either L. acidophilus L10 or L. fermentum PC2 were also administered to a group. All mice were challenged with viable S. Typhimurium on day 28. On day 10 post challenge, the study was terminated and microbial and immunological parameters were assessed. Mice dosed with L. fermentum PC2 in addition to the vaccine had a significantly enhanced S. Typhimurium humoral response. The mice in this group had high levels of lactobacilli in the feces and in association with the Peyer's patches, no detectable levels of either lactobacilli or S. Typhimurium in the spleen, and no detectable weight loss. Mice given L. acidophilus L10 with the vaccine were unable to exhibit elevated S. Typhimurium specific humoral responses. However, there was no detectable S. Typhimurium in the spleens of this group. Interestingly, translocation of lactobacilli into the spleen was observed as well as a slight weight loss was noted in mice that received the L. acidophilus L10 with the vaccine. This study shows that, the L. fermentum PC2 had a greater capacity than the L. acidophilus L10 to act as an oral adjuvant in a S. Typhimurium oral vaccine program and afforded greater protection against a live S. Typhimurium challenge.

  7. Potassium conductance dynamics confer robust spike-time precision in a neuromorphic model of the auditory brain stem

    PubMed Central

    Boahen, Kwabena

    2013-01-01

    A fundamental question in neuroscience is how neurons perform precise operations despite inherent variability. This question also applies to neuromorphic engineering, where low-power microchips emulate the brain using large populations of diverse silicon neurons. Biological neurons in the auditory pathway display precise spike timing, critical for sound localization and interpretation of complex waveforms such as speech, even though they are a heterogeneous population. Silicon neurons are also heterogeneous, due to a key design constraint in neuromorphic engineering: smaller transistors offer lower power consumption and more neurons per unit area of silicon, but also more variability between transistors and thus between silicon neurons. Utilizing this variability in a neuromorphic model of the auditory brain stem with 1,080 silicon neurons, we found that a low-voltage-activated potassium conductance (gKL) enables precise spike timing via two mechanisms: statically reducing the resting membrane time constant and dynamically suppressing late synaptic inputs. The relative contribution of these two mechanisms is unknown because blocking gKL in vitro eliminates dynamic adaptation but also lengthens the membrane time constant. We replaced gKL with a static leak in silico to recover the short membrane time constant and found that silicon neurons could mimic the spike-time precision of their biological counterparts, but only over a narrow range of stimulus intensities and biophysical parameters. The dynamics of gKL were required for precise spike timing robust to stimulus variation across a heterogeneous population of silicon neurons, thus explaining how neural and neuromorphic systems may perform precise operations despite inherent variability. PMID:23554436

  8. Label-free vascular imaging in a spontaneous hamster cheek pouch carcinogen model for pre-cancer detection (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Hu, Fangyao; Morhard, Robert; Liu, Heather; Murphy, Helen; Farsiu, Sina; Ramanujam, Nimmi

    2016-03-01

    Inducing angiogenesis is one hallmark of cancer. Tumor induced neovasculature is often characterized as leaky, tortuous and chaotic, unlike a highly organized normal vasculature. Additionally, in the course of carcinogenesis, angiogenesis precedes a visible lesion. Tumor cannot grow beyond 1-2 mm in diameter without inducing angiogenesis. Therefore, capturing the event of angiogenesis may aid early detection of pre-cancer -important for better treatment prognoses in regions that lack the resources to manage invasive cancer. In this study, we imaged the neovascularization in vivo in a spontaneous hamster cheek pouch carcinogen model using a, non-invasive, label-free, high resolution, reflected-light spectral darkfield microscope. Hamsters' cheek pouches were painted with 7,12-Dimethylbenz[a]anthracene (DMBA) to induce pre-cancerous to cancerous changes, or mineral oil as control. High resolution spectral darkfield images were obtained over the course of pre-cancer development and in control cheek pouches. The vasculature was segmented with a multi-scale Gabor filter with an 85% accuracy compared with manually traced masks. Highly tortuous vasculature was observed only in the DMBA treated cheek pouches as early as 6 weeks of treatment. In addition, the highly tortuous vessels could be identified before a visible lesion occurred later during the treatment. The vessel patterns as determined by the tortuosity index were significantly different from that of the control cheek pouch. This preliminary study suggests that high-resolution darkfield microscopy is promising tool for pre-cancer and early cancer detection in low resource settings.

  9. NIR fluorescent image-based evaluation of gastric tube perfusion after esophagectomy in preclinical model (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Kim, Minji; Quan, Yuhua; Han, Kook Nam; Choi, Byeong Hyun; Choi, Yeonho; Kim, Hyun Koo; Kim, Beop-Min

    2016-03-01

    This study was to evaluate the feasibility of near infrared (NIR) fluorescent images as a tool for evaluating the perfusion of the gastric tube after esophagectomy. In addition, we investigated the time required to acquire enough signal to confirm the presence of ischemia in gastric tube after injection of indocyanine green (ICG) through peripheral versus and central venous route. 4 porcine underwent esophagogastrostomy and their right gastric arteries were ligated to mimic ischemic condition of gastric tube. ICG (0.6mg/kg) was intravenously injected and the fluorescence signal-to-background ratios (SBR) were measured by using the custom-built intraoperative color and fluorescence imaging system (ICFIS). We evaluated perfusion of gastric tubes by comparing their SBR with esophageal SBR. In ischemic models, SBR of esophagus was higher than that of gastric tube (2.8+/-0.54 vs. 1.7+/-0.37, p<0.05). It showed high esophagus-stomach signal to signal ratio. (SSR, 1.8+/-0.76). We also could observe recovery of blood perfusion in few minutes after releasing the ligation of right gastric artery. In addition, in comparison study according to the injection route of ICG, The time to acquire signal stabilization was faster in central than in peripheral route (119 +/- 65.1 seconds in central route vs. 295+/-130.4 in peripheral route, p<0.05). NIR fluorescent images could provide the real-time information if there was ischemia or not in gastric tube during operation. And, central injection of ICG might give that information faster than peripheral route.

  10. Energy optimization of water and wastewater management for municipal and industrial applications conference

    SciTech Connect

    Not Available

    1980-08-01

    These proceedings document the presentations given at the Energy Optimization of Water and Wastewater Management for Municipal and Industrial Applications, Conference, sponsored by the Department of Energy (DOE). The conference was organized and coordinated by Argonne National Laboratory. The conference focused on energy use on conservation in water and wastewater. The General Session also reflects DOE's commitment to the support and development of waste and wastewater systems that are environmentally acceptable. The conference proceedings are divided into two volumes. Volume 1 contains the General Session and Sessions 1 to 5. Volume 2 covers Sessions 6 to 12. Separate abstracts are prepared for each item within the scope of the Energy Data Base.

  11. Energy optimization of water and wastewater management for municipal and industrial applications conference

    SciTech Connect

    Not Available

    1980-08-01

    These proceedings document the presentations given at the Energy Optimization of Water and Wastewater Management for Municipal and Industrial Applications Conference, sponsored by the Department of Energy (DOE). The conference was organized and coordinated by Argonne National Laboratory. The conference focused on energy use and conservation in water and wastewater. The General Session also reflects DOE's commitment to the support and development of waste and wastewater systems that are environmentally acceptable. The conference proceedings are divided into two volumes. Volume 1 contains the General Session and Sessions 1 to 5. Volume 2 covers Sessions 6 to 12. Separate abstracts are prepared for each item within the scope of the Energy Data Base.

  12. A Conceptual Framework for Evaluating the Domains of Applicability of Ecological Models and its Implementation in the Ecological Production Function Library - International Society for Ecological Modelling Conference

    EPA Science Inventory

    The use of computational ecological models to inform environmental management and policy has proliferated in the past 25 years. These models have become essential tools as linkages and feedbacks between human actions and ecological responses can be complex, and as funds for sampl...

  13. Building network management system for video conference system in intranet

    NASA Astrophysics Data System (ADS)

    Li, Hui; Bai, Lin; Ji, Yuefeng

    2004-04-01

    To provide visual communication over enterprise Intranet, the video conference system in H.323 has been proposed as a suitable architecture to take the place of circuit-switched telephony model. However, managing video conference system will be complicated due to the real-time monitoring and reporting. This paper presents some research on the network management of H.323 Video conference system, and introduces the standards about this system, such as ITU-T H.341 and H.350 recommendation, and then gives some advices on network management design for video conference system with the considering of the real-time feature.

  14. DOE ZERH Case Study: Charles Thomas Homes, Anna Model, Omaha, NE

    SciTech Connect

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning custom home in the cold climate that got a HERS 48 without PV, with 2x6 24” on center walls with R-23 blown fiberglass, ocsf at rim joists, basement with plus 2x4 stud walls with R-23 blown fiberglass, with R-20 around slab, R-38 under slab; a vented attic with R-100 blown cellulose; 95% AFUE furnace, 14 SEER AC, ERV; heat pump water heater.

  15. Comparison of computer codes and inputs used at DOE sites to model intrusion scenarios

    SciTech Connect

    Seitz, R.R.; Cook, J.R.; Wood, M.I.; Rittman, P.D.; Wood, D.E.; Napier, B.A.

    1994-09-01

    Scenarios and computer codes used to evaluate intrusion scenarios at different DOE sites are compared and discussed. The purpose of the comparison is to identify differences in the approaches and areas where approaches could be made more consistent without ignoring the need to consider legimate site-specific differences, The comparison is comprised of two steps: (1) benchmarking of CENII and PATHRAE (the two most commonly used codes at DOE sites), and (2) comparison of assumed values for selected input parameters from:scenarios used at the different sites. The results of the benchmarking and parameter comparisons identify fundamental differences in the default assumptions used in the computer codes, as well as differences in the approaches used at the different sites. GENII and PATHRAE are applied to a variety of sites within DOE and other regulatory environments, differences in default assumptions identified in these comparisons are discussed for users to consider when they apply the codes. Furthermore, differences in assumptions made at the different sites disposing of low-level radioactive wastes within Department of Energy are identified to provide an example of how the Performance Assessment Task Team is working to ensure consistent interpretation of performance assessment results.

  16. EDITORIAL: Micromechanics. Selected papers from the 5th International Conference on Multiscale Materials Modeling (Freiburg, Germany, 4-8 October 2010) Micromechanics. Selected papers from the 5th International Conference on Multiscale Materials Modeling (Freiburg, Germany, 4-8 October 2010)

    NASA Astrophysics Data System (ADS)

    Van der Giessen, E.; Geers, M.; Li, J.

    2011-10-01

    This special issue contains a selection of papers presented at the Micromechanics minisymposium within the 5th Multiscale Materials Modeling (MMM2010) Conference held in Freiburg, Germany, 4-8 October 2010. Being selected from this minisymposium, all papers deal primarily with mechanical properties but sometimes coupled to other physical phenomena. In line with the scope of the MMM conference series, these selected papers reflect the state-of-the-art in a wide range of multiscale simulation techniques including molecular dynamics and dislocation dynamics up to enhanced finite element methods and phase field modeling for continuous solids. A wide variety of materials is addressed, including polymers, nano-structured as well as multiphase metals up to ferroelectric ceramics. Another way of clustering the papers in this issue is by the kind of phenomena being studied: plasticity or fracture. The first six papers deal with plasticity in crystalline metals and address two central issues: (i) how do the carriers of plastic deformation, i.e. dislocations, interact with other elements of the microstructure, and (ii) what are the origins of plasticity size effects? The papers by Brandl et al and by Shi et al not only show the importance of grain boundaries and other interfaces, but the latter is also one of the first studies where dislocation motion is coupled to phase transitions in parts of the microstructure. These papers, but even more so the single crystal studies by Senger et al, also highlight the importance of the initial dislocation structure. Hudzinskyy and Lyulin show that a similar dependence of the initial structure in amorphous polymers is responsible for its peculiar inelastic response. The innovative method to simulate damage-induced localization presented by Coenen et al forms a bridge to the fracture studies that close this issue. Both these papers continue on the theme of microstructural effects, while the last one by Ambollahi et al closes the loop to

  17. The DOE s In-Plant Training (INPLT) Model to Promote Energy Efficiency in the Industrial Sector

    SciTech Connect

    Alkadi, Nasr E; Nimbalkar, Sachin U; De Fontaine, Mr. Andre; Schoeneborn, Fred C

    2013-01-01

    In-Plant Training (INPLT) is a new model for developing energy efficiency expertise within the US manufacturing companies participating in the U.S. Department of Energy s (DOE s) Better Buildings, Better Plants Program-a nationwide initiative to drive a 25% reduction in industrial energy intensity in 10 years. INPLTs are designed to fill a market niche by providing hands on training in a real world manufacturing plant environment. Through INPLTs, participants from multiple manufacturing plants, supply chains, utilities, and other external stakeholders learn how to conduct energy assessments, use energy analysis tools to analyze energy saving opportunities, develop energy management systems, and implement energy savings projects. Typical INPLT events are led by DOE-certified Energy Experts and range from 2-4 days. Topics discussed include: identification of cross-cutting or system specific opportunities; introduction to ISO 50001 Energy Management Systems; and energy project implementation and replication. This model is flexible, and can be tailored to suit the needs of specific industries. The INPLTs are a significant departure from the traditional single plant energy assessment model previously employed by DOE. INPLTs shift the focus from the concept of a single-plant s energy profile to a broader focus on training and capacity building among multiple industrial participants. The objective is to enable trainees to identify, quantify, implement and replicate future energy saving projects without continued external assistance. This paper discusses the INPLT model and highlights some of the initial outcomes from the successfully delivered INPLTs and the overall impact in terms of numbers of plants/participants trained, impacted energy footprints, and potential replication of identified opportunities.

  18. FOREWORD: HELAS II International Conference

    NASA Astrophysics Data System (ADS)

    Gizon, Laurent; Roth, Markus

    2008-07-01

    Volume 118 (2008) of Journal of Physics: Conference Series provides a written record of the talks and posters presented at the HELAS II International Conference `Helioseismology, Asteroseismology and MHD Connections'. The conference was held during the week 20-24 August 2007 in Göttingen, Germany, jointly hosted by the Max Planck Institute for Solar System Research and the Faculty of Physics of the University of Göttingen. A total of 140 scientists from all over the world attended. The Scientific Organizing Committee consisted of Conny Aerts, Annie Baglin, Jørgen Christensen-Dalsgaard, Thierry Corbard, Jadwiga Daszyńska-Daszkiewicz, Stefan Dreizler, Yvonne Elsworth, Laurent Gizon (Chairman), Wolfgang Glatzel, Frank Hill, Donald Kurtz, Oskar von der Lühe, Maria Pia Di Mauro, Mário Monteiro, Pere Pallé, Markus Roth, Philip Scherrer, Manfred Schüssler, and Michael Thompson. HELAS stands for the European Helio- and Asteroseismology Network, a Coordination Action supported by the sixth Framework Programme of the European Union. It aims to bring together researchers in the fields of solar and stellar oscillations. This volume consists of 91 articles organized into sections that reflect the scientific programme of the conference: 012001-07 Wave diagnostics in physics, geophysics and astrophysics 012008-09 Perspectives on helio- and asteroseismology 012010-17 Asteroseismology: Observations 012018-25 Asteroseismology: Theory 012026-32 Global helioseismology and solar models 012033-38 Local helioseismology and magnetic activity 012039-44 Future observational projects in helio- and asteroseismology 012045-91 Poster papers. The overwhelming majority of papers discuss the seismology of the Sun and stars. Papers in the first section provide a broader perspective on wave phenomena and techniques for probing other physical systems, from living beings to the universe as a whole. We were extremely fortunate to have particularly distinguished experts to cover these topics

  19. Common challenges for ecological modelling: synthesis of facilitated discussions held at the symposia organized for the 2009 conference of the International Society for Ecological Modelling in Quebec City, Canada, (October 6-9, 2009)

    USGS Publications Warehouse

    Larocque, Guy R.; Mailly, D.; Yue, T.-X.; Anand, M.; Peng, C.; Kazanci, C.; Etterson, M.; Goethals, P.; Jorgensen, S.E.; Schramski, J.R.; McIntire, E.J.B.; Marceau, D.J.; Chen, B.; Chen, G.Q.; Yang, Z.F.; Novotna, B.; Luckai, N.; Bhatti, Jagtar S.; Liu, J.; Munson, A.; Gordon, Andrew M.; Ascough, J.C.

    2011-01-01

    The eleven symposia organized for the 2009 conference of the International Society for Ecological Modelling (ISEM 2009) held in Quebec City, Canada, October 6–9, 2009, included facilitated discussion sessions following formal presentations. Each symposium focused on a specific subject, and all the subjects could be classified into three broad categories: theoretical development, population dynamics and ecosystem processes. Following discussions with the symposia organizers, which indicated that they all shared similar issues and concerns, the facilitated discussions were task-oriented around four basic questions: (1) key challenges in the research area, (2) generating and sharing new ideas, (3) improving collaboration and networking, and (4) increasing visibility to decision-makers, partners and clients. Common challenges that emerged from the symposia included the need for improved communication and collaboration among different academic disciplines, further progress in both theoretical and practical modelling approaches, and accentuation of technology transfer. Regarding the generation and sharing of new ideas, the main issue that emerged was the type of positive interactions that should be encouraged among potential collaborators. The usefulness of the Internet, particularly for the sharing of open-source software and conducting discussion forums, was highlighted for improving collaboration and networking. Several communication tools are available today, and it is important for modellers to use them more intensively. Visibility can be increased by publishing professional newsletters, maintaining informal contacts with the public, organizing educational sessions in primary and secondary schools, and developing simplified analytical frameworks and pilot studies. Specific issues raised in each symposium are also discussed.

  20. General Information: Chapman Conference on Magnetospheric Current Systems

    NASA Technical Reports Server (NTRS)

    Spicer, Daniel S.; Curtis, Steven

    1999-01-01

    The goal of this conference is to address recent achievements of observational, computational, theoretical, and modeling studies, and to foster communication among people working with different approaches. Electric current systems play an important role in the energetics of the magnetosphere. This conference will target outstanding issues related to magnetospheric current systems, placing its emphasis on interregional processes and driving mechanisms of current systems.

  1. Proceedings of the international conference on cybernetics and societ

    SciTech Connect

    Not Available

    1985-01-01

    This book presents the papers given at a conference on artificial intelligence, expert systems and knowledge bases. Topics considered at the conference included automating expert system development, modeling expert systems, causal maps, data covariances, robot vision, image processing, multiprocessors, parallel processing, VLSI structures, man-machine systems, human factors engineering, cognitive decision analysis, natural language, computerized control systems, and cybernetics.

  2. 78 FR 27963 - Reliability Technical Conference; Notice of Technical Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Reliability Technical Conference; Notice of Technical Conference Take notice that the Federal Energy Regulatory Commission will hold a Technical Conference on Tuesday, July 9,...

  3. Microparticle-Mediated Transfer of the Viral Receptors CAR and CD46, and the CFTR Channel in a CHO Cell Model Confers New Functions to Target Cells

    PubMed Central

    Gonzalez, Gaëlle; Vituret, Cyrielle; Di Pietro, Attilio; Chanson, Marc; Boulanger, Pierre; Hong, Saw-See

    2012-01-01

    Cell microparticles (MPs) released in the extracellular milieu can embark plasma membrane and intracellular components which are specific of their cellular origin, and transfer them to target cells. The MP-mediated, cell-to-cell transfer of three human membrane glycoproteins of different degrees of complexity was investigated in the present study, using a CHO cell model system. We first tested the delivery of CAR and CD46, two monospanins which act as adenovirus receptors, to target CHO cells. CHO cells lack CAR and CD46, high affinity receptors for human adenovirus serotype 5 (HAdV5), and serotype 35 (HAdV35), respectively. We found that MPs derived from CHO cells (MP-donor cells) constitutively expressing CAR (MP-CAR) or CD46 (MP-CD46) were able to transfer CAR and CD46 to target CHO cells, and conferred selective permissiveness to HAdV5 and HAdV35. In addition, target CHO cells incubated with MP-CD46 acquired the CD46-associated function in complement regulation. We also explored the MP-mediated delivery of a dodecaspanin membrane glycoprotein, the CFTR to target CHO cells. CFTR functions as a chloride channel in human cells and is implicated in the genetic disease cystic fibrosis. Target CHO cells incubated with MPs produced by CHO cells constitutively expressing GFP-tagged CFTR (MP-GFP-CFTR) were found to gain a new cellular function, the chloride channel activity associated to CFTR. Time-course analysis of the appearance of GFP-CFTR in target cells suggested that MPs could achieve the delivery of CFTR to target cells via two mechanisms: the transfer of mature, membrane-inserted CFTR glycoprotein, and the transfer of CFTR-encoding mRNA. These results confirmed that cell-derived MPs represent a new class of promising therapeutic vehicles for the delivery of bioactive macromolecules, proteins or mRNAs, the latter exerting the desired therapeutic effect in target cells via de novo synthesis of their encoded proteins. PMID:23284987

  4. Cranfield Conference on Information Retrieval.

    ERIC Educational Resources Information Center

    Kuo, Franklin F.

    The Third Cranfield Conference on Mechanised Information Storage and Retrieval Systems was held on 20-23 July 1971 in Cranfield, England. The report describes a number of the key papers presented at this conference. (Author)

  5. Planning a Women's Studies Conference.

    ERIC Educational Resources Information Center

    Saul, Jean Rannells

    1992-01-01

    Describes the organization and implementation of a women's studies conference. Discusses fund raising, identifying speakers, developing publicity, local arrangement efforts, and providing hospitality. Includes nine recommendations and a suggested conference timeline. (CFR)

  6. Annual Conference Abstracts

    ERIC Educational Resources Information Center

    Engineering Education, 1976

    1976-01-01

    Presents the abstracts of 158 papers presented at the American Society for Engineering Education's annual conference at Knoxville, Tennessee, June 14-17, 1976. Included are engineering topics covering education, aerospace, agriculture, biomedicine, chemistry, computers, electricity, acoustics, environment, mechanics, and women. (SL)

  7. Government Quality Conference Proceedings

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The Government Quality Conference was an attempt to bring together executive organizations and senior individuals in the Federal Government that have a desire to improve productivity. It was designed to provide an exchange of ideas based on experience, and to encourage individual management initiatives to tap the capabilities of Federal employees.

  8. Conducting Telephone Conference IEPs

    ERIC Educational Resources Information Center

    Patterson, Philip Patrick; Petit, Constance; Williams, Shandelyn

    2007-01-01

    Synchronizing the availability of team members for Individual Education Plan (IEP) meetings can be a daunting task. Fortunately, the Individuals with Disabilities Education Improvement Act of 2004 permits alternative means of conducting such meetings. An example of an alternate means is a telephone conference, whereby parents communicate over the…

  9. Conference Rules, Part 1

    ERIC Educational Resources Information Center

    Kerber, Linda K.

    2008-01-01

    Most academic conferences are preceded by some effort to make the sessions different from the usual format, but the usual format overwhelmingly prevails. That is: Each panel discussion runs no longer than two hours, during which two, three, or four specialists stand at a lectern and talk. Sometimes they will read a prepared paper; sometimes they…

  10. International waste management conference

    SciTech Connect

    Not Available

    1989-01-01

    This book contains the proceedings of the international waste management conference. Topics covered include: Quality assurance in the OCR WM program; Leading the spirit of quality; Dept. of Energy hazardous waste remedial actions program; management of hazardous waste projects; and System management and quality assurance.

  11. REGIONAL CONFERENCE SUMMARIES, 1966.

    ERIC Educational Resources Information Center

    Bureau of Adult, Vocational, and Technical Education (DHEW/OE), Washington, DC. Div. of Vocational and Technical Education.

    AN AVERAGE OF 200 TEACHER EDUCATORS, STATE DIRECTORS, LAYMEN, AND REPRESENTATIVES OF VARIOUS AGENCIES ATTENDED EACH OF NINE REGIONAL CONFERENCES CONDUCTED THROUGHOUT THE UNITED STATES TO DISCUSS THE INFLUENCE OF SOCIAL AND ECONOMIC CHANGES AND PROBLEMS IN PLANNING AND CONDUCTING VOCATIONAL AND TECHNICAL EDUCATION PROGRAMS. MAJOR SPEECHES PRESENTED…

  12. Grammar! A Conference Report.

    ERIC Educational Resources Information Center

    King, Lid, Ed.; Boaks, Peter, Ed.

    Papers from a conference on the teaching of grammar, particularly in second language instruction, include: "Grammar: Acquisition and Use" (Richard Johnstone); "Grammar and Communication" (Brian Page); "Linguistic Progression and Increasing Independence" (Bernardette Holmes); "La grammaire? C'est du bricolage!" ("Grammar? That's Hardware!") (Barry…

  13. Annual Conference Abstracts

    ERIC Educational Resources Information Center

    Journal of Engineering Education, 1972

    1972-01-01

    Includes abstracts of papers presented at the 80th Annual Conference of the American Society for Engineering Education. The broad areas include aerospace, affiliate and associate member council, agricultural engineering, biomedical engineering, continuing engineering studies, chemical engineering, civil engineering, computers, cooperative…

  14. Metabolic Engineering X Conference

    SciTech Connect

    Flach, Evan

    2015-05-07

    The International Metabolic Engineering Society (IMES) and the Society for Biological Engineering (SBE), both technological communities of the American Institute of Chemical Engineers (AIChE), hosted the Metabolic Engineering X Conference (ME-X) on June 15-19, 2014 at the Westin Bayshore in Vancouver, British Columbia. It attracted 395 metabolic engineers from academia, industry and government from around the globe.

  15. APPA 2011 Conference Highlights

    ERIC Educational Resources Information Center

    Facilities Manager, 2011

    2011-01-01

    This article presents highlights of APPA conference that was held on July 16-18, 2011. The highlights feature photos of 2011-2012 board of directors, outgoing senior regional representatives to the board, meritorious service award, APPA fellow, president's recognition and gavel exchange, and diamond business partner award.

  16. Creating Better Satellite Conferences.

    ERIC Educational Resources Information Center

    Horner, Tommy

    1998-01-01

    Presents four ways to improve broadcasts of company satellite conferences, including creative site selection (using facilities at educational institutions rather than hotel rooms); creative programming (using graphics and other interruptions to break up lectures or speeches); creative crew selection; and creative downlink site activities (to…

  17. Conference on Censorship.

    ERIC Educational Resources Information Center

    Meltzer, Milton; And Others

    In this collection of seven speeches from the University of Missouri Conference on Censorship, writers focus on the various aspects of censorship. Speeches are by (1) Milton Meltzer, who lauds those writers who were forced to battle with censors; (2) Enid Olson, who explores the censorship problems faced by teachers and school librarians; (3)…

  18. The interparliamentary conference

    SciTech Connect

    Not Available

    1990-01-01

    The purpose of this conference was to provide a forum for exchange of information on environmental problems with global origins and consequences. The areas of major concern included the following: global climate change; deforestation and desertification; preservation of biological diversity; safeguarding oceans and water resources; population growth; destruction of the stratospheric ozone layer; and sustainable development.

  19. Microbicides 2006 conference

    PubMed Central

    Ramjee, Gita; Shattock, Robin; Delany, Sinead; McGowan, Ian; Morar, Neetha; Gottemoeller, Megan

    2006-01-01

    Current HIV/AIDS statistics show that women account for almost 60% of HIV infections in Sub-Saharan Africa. HIV prevention tools such as male and female condoms, abstinence and monogamy are not always feasible options for women due to various socio-economic and cultural factors. Microbicides are products designed to be inserted in the vagina or rectum prior to sex to prevent HIV acquisition. The biannual Microbicides conference took place in Cape Town, South Africa from 23–26 April 2006. The conference was held for the first time on the African continent, the region worst affected by the HIV/AIDS pandemic. The conference brought together a record number of 1,300 scientists, researchers, policy makers, healthcare workers, communities and advocates. The conference provided an opportunity for an update on microbicide research and development as well as discussions around key issues such as ethics, acceptability, access and community involvement. This report discusses the current status of microbicide research and development, encompassing basic and clinical science, social and behavioural science, and community mobilisation and advocacy activities. PMID:17038196

  20. 2002 NASPSA Conference Abstracts.

    ERIC Educational Resources Information Center

    Journal of Sport & Exercise Psychology, 2002

    2002-01-01

    Contains abstracts from the 2002 conference of the North American Society for the Psychology of Sport and Physical Activity. The publication is divided into three sections: the preconference workshop, "Effective Teaching Methods in the Classroom;" symposia (motor development, motor learning and control, and sport psychology); and free…

  1. On the Conference Circuit.

    ERIC Educational Resources Information Center

    Tyckoson, David A.

    1987-01-01

    Summarizes three conference presentations on the effects of the economic climate on academic libraries in Iowa. These presentations focused on the impact of austerity budgets on collection development, library services and personnel, and possible management approaches to retrenchment in these areas. (CLB)

  2. Conference on Navajo Orthography.

    ERIC Educational Resources Information Center

    Ohannessian, Sirarpi; And Others

    This report on the Conference on Navajo Orthography, held in Albuquerque, New Mexico on May 2-3, 1969 constitutes a summary of the discussion and decisions of a meeting which was convened by the Center for Applied Linguistics under contract with the Bureau of Indian Affairs to agree on an orthography for the Navajo language. The immediate purpose…

  3. Report on the Conference.

    ERIC Educational Resources Information Center

    Brown, Ralph S.

    1983-01-01

    The themes of the 1982 annual conference of the American Association of University Professors are outlined. They include the importance of planning, selective versus across-the-board retrenchment strategies, definitions and problems of financial exigency, program reduction, and affirmative action claims. (MSE)

  4. Open Mind Conference

    NASA Technical Reports Server (NTRS)

    King, Alexander H.

    1995-01-01

    Open Mind, The Association for the achievement of diversity in higher education, met in conference in Albuquerque, New Mexico, between October 16 and 18, 1992. A number of workgroups met to discuss the goals, structure, and generally evaluate the Association and its achievements. A summary of the workgroup sessions and their minutes are included.

  5. A Conference of Hope.

    ERIC Educational Resources Information Center

    American Printing House for the Blind, Louisville, KY. Dept. of Educational Research.

    Presented are the proceedings of the First Historic Helen Keller World Conference on Services to Deaf-Blind Youths and Adults, held in New York City in September, 1977 on the theme "The Deaf-Blind Person in the Community." Reports have the following titles and authors: "Definition, Demography, Causes and Prevention of Deaf-Blindness; Finding and…

  6. IATUL Conference 1985.

    ERIC Educational Resources Information Center

    Information Services and Use, 1985

    1985-01-01

    Summarizes presentations at conference on theme "The future of information resources for science and technology and role of libraries": industrial and commercial use of national, regional, and university resources; balance between public- and private-sector resources; local access in national and regional context; access to information in…

  7. When does 1/2 = 1/3?: Modelling with Wet Fractions

    ERIC Educational Resources Information Center

    Fitzallen, Noleine

    2015-01-01

    Many fraction activities rely on the use of area models for developing partitioning skills. These models, however, are limited in their ability to assist students to visualise a fraction of an object when the whole changes. This article describes a fraction modelling activity that requires the transfer of water from one container to another. The…

  8. Does attainment of Piaget's formal operational level of cognitive development predict student understanding of scientific models?

    NASA Astrophysics Data System (ADS)

    Lahti, Richard Dennis, II

    Knowledge of scientific models and their uses is a concept that has become a key benchmark in many of the science standards of the past 30 years, including the proposed Next Generation Science Standards. Knowledge of models is linked to other important nature of science concepts such as theory change which are also rising in prominence in newer standards. Effective methods of instruction will need to be developed to enable students to achieve these standards. The literature reveals an inconsistent history of success with modeling education. These same studies point to a possible cognitive development component which might explain why some students succeeded and others failed. An environmental science course, rich in modeling experiences, was used to test both the extent to which knowledge of models and modeling could be improved over the course of one semester, and more importantly, to identify if cognitive ability was related to this improvement. In addition, nature of science knowledge, particularly related to theories and theory change, was also examined. Pretest and posttest results on modeling (SUMS) and nature of science (SUSSI), as well as data from the modeling activities themselves, was collected. Cognitive ability was measured (CTSR) as a covariate. Students' gain in six of seven categories of modeling knowledge was at least medium (Cohen's d >.5) and moderately correlated to CTSR for two of seven categories. Nature of science gains were smaller, although more strongly correlated with CTSR. Student success at creating a model was related to CTSR, significantly in three of five sub-categories. These results suggest that explicit, reflective experience with models can increase student knowledge of models and modeling (although higher cognitive ability students may have more success), but successfully creating models may depend more heavily on cognitive ability. This finding in particular has implications in the grade placement of modeling standards and

  9. The Dischma river mystery: why does my snow hydrological model not work here ?

    NASA Astrophysics Data System (ADS)

    Schaefli, Bettina; Ceperley, Natalie; Brauchli, Tristan; Lehning, Michael; Jonas, Tobias; Zappa, Massimiliano

    2016-04-01

    During recent model development for hydrologic prediction in high Alpine areas, we noticed that a relatively simple snow hydrological model (SEHR-ECHO model) shows a surprising divergence from observed discharge over prolonged periods of time (several years) for the high Alpine Dischma catchment (Swiss Alps). We started a detailed data analysis including downstream discharge observations, the meteorological observations and a qualitative assessment of snow cover maps during these years (showing no particularly extreme patterns during these years). We also completed, a series of re-calibration experiments and a detailed comparison to the simulation results from other similar hydrological models and from a physics-based snow model (Alpine3D). All models use their own description of the precipitation and temperature input fields that are derived from a similar set of meteorological stations. The simple models compute snow melt from air temperature alone and use similar hydrologic process descriptions. All three simple models show a similar divergence from observed discharge data, especially during summer months. A comparison to discharge simulations from the model Alpine3D shows that this physics-based model is able to reproduce the observed discharge relatively well during these summer periods. It shows, in exchange, a surprising divergence from observed discharge during early spring, when the calibrated simple models fit the observed data well. These results might point towards a misfit of the simple models to potentially wrong discharge observations during early spring or indicate that the physics-based model has problems reproducing snowmelt-induced discharge during this period. In conclusion, the question remains to date unanswered what might cause the departure of the simple snow model simulations from the observed discharge data. We look forward to the discussion with modellers and experimentalists to collect new ideas on how to resolve this mystery.

  10. Development of a techno-economic model to optimization DOE spent nuclear fuel disposition

    SciTech Connect

    Ramer, R.J.; Plum, M.M.; Adams, J.P.; Dahl, C.A.

    1997-11-01

    The purpose of the National Spent Nuclear Fuel (NSNF) Program conducted by Lockheed Martin Idaho Technology Co. (LMITCO) at the Idaho National Engineering and Environmental Laboratory (INEEL) is to evaluate what to do with the spent nuclear fuel (SNF) in the Department of Energy (DOE) complex. Final disposition of the SNF may require that the fuel be treated to minimize material concerns. The treatments may range from electrometallurgical treatment and chemical dissolution to engineering controls. Treatment options and treatment locations will depend on the fuel type and the current locations of the fuel. One of the first steps associated with selecting one or more sites for treating the SNF in the DOE complex is to determine the cost of each option. An economic analysis will assist in determining which fuel treatment alternative attains the optimum disposition of SNF at the lowest possible cost to the government and the public. For this study, a set of questions was developed for the electrometallurgical treatment process for fuels at several locations. The set of questions addresses all issues associated with the design, construction, and operation of a production facility. A matrix table was developed to determine questions applicable to various fuel treatment options. A work breakdown structure (WBS) was developed to identify a treatment process and costs from initial design to shipment of treatment products to final disposition. Costs will be applied to determine the life-cycle cost of each option. This technique can also be applied to other treatment techniques for treating spent nuclear fuel.

  11. Development of a Techno-Economic Model to Optimize DOE Spent Nuclear Fuel Disposition

    SciTech Connect

    Ramer, R. J.; Plum, M. M.; Adams, J. P.; Dahl, C. A.

    1998-02-01

    The National Spent Nuclear Fuel (NSNF) Program is evaluating final disposition of spent nuclear fuel (SNE) in the Department of Energy (DOE) complex. Final disposition of SNF may require that the fuel be treated to minimize material concerns. The treatments may range from electrometallurgical treatment (EMT) and chemical dissolution to engineering controls. Treatment options and treatment locations will depend on fuel type and location of the fuel. One of the first steps associated with selecting one or more sites for treating SNF in the DOE complex is to determine the cost of each option. An economic analysis will assist in determining which fuel treatment alternative attains the optimum disposition of SNF at the lowest possible cost to the government and the public. For this study, a set of questions was developed for the EMT process for fuels at several locations. The set of questions addresses all issues associated with design, construction, and operation of a production facility. A matrix table was developed to determine questions applicable to various fuel treatment options. A work breakdown structure (WBS) was developed to identify a treatment process and costs from initial design to shipment of treatment products to final disposition. Costs can be applied to determine the life cycle cost of each option. This technique can also be applied to other treatment techniques for treating SNF.

  12. Pyrolysis of simple coal model compounds containing aromatic carboxylic acids: Does decarboxylation lead to cross-linking?

    SciTech Connect

    Eskay, T.P.; Britt, P.F.; Buchanan, A.C. III

    1996-02-01

    The thermolysis of two aromatic carboxylic acids 1,2-(3,3`-dicarboxyphenyl)ethane (2) have been investigated at 400{degree} C as models of carboxylic acids in low rank coals. The major decomposition pathway observed is decarboxylation, which mainly occurs by an ionic pathway. This decarboxylation route does not lead to any significant amount of coupling or high molecular weight products that would be indicative of cross-linking products in coal. The pyrolysis of 1 and 2 will be investigated under a variety of conditions that better mimic the enviromment found in coal to further delineate the role that decarboxylation plays in coal cross-linking chemistry.

  13. ALA Conference 2009: Chicago Hope

    ERIC Educational Resources Information Center

    Berry, John N., III

    2009-01-01

    There is joy among those who have the funds to go to Chicago for the American Library Association (ALA) annual conference, July 9-15. Every librarian knows there is nothing better than a Chicago gathering, with the city's wonderful haunts, museums, restaurants, and fine memories of past conferences. The conference program covers nearly every…

  14. Summary: A Very Timely Conference

    NASA Astrophysics Data System (ADS)

    Wyse, Rosemary F. G.

    2012-04-01

    The conference poster includes a very apt phrase that describes a primary motivation for this conference: Time discovers truth. This aphorism, attributed to Seneca, was certainly affirmed by the many exciting talks and discussions at this conference, in both formal and informal settings.

  15. Final Report. DOE Computational Nanoscience Project DE-FG02-03ER46096: Integrated Multiscale Modeling of Molecular Computing Devices

    SciTech Connect

    Cummings, Peter

    2009-11-15

    The document is the final report of the DOE Computational Nanoscience Project DE-FG02-03ER46096: Integrated Multiscale Modeling of Molecular Computing Devices. It included references to 62 publications that were supported by the grant.

  16. Antibody Engineering and Therapeutics Conference

    PubMed Central

    Almagro, Juan Carlos; Gilliland, Gary L; Scott, Jamie; Larrick, James W; Plückthun, Andreas; Veldman, Trudi; Adams, Gregory P; Parren, Paul WHI; Chester, Kerry A; Bradbury, Andrew; Reichert, Janice M; Huston, James S

    2013-01-01

    The Antibody Engineering and Therapeutics conference, which serves as the annual meeting of The Antibody Society, will be held in Huntington Beach, CA from Sunday December 8 through Thursday December 12, 2013. The scientific program will cover the full spectrum of challenges in antibody research and development, and provide updates on recent progress in areas from basic science through approval of antibody therapeutics. Keynote presentations will be given by Leroy Hood (Institute of System Biology), who will discuss a systems approach for studying disease that is enabled by emerging technology; Douglas Lauffenburger (Massachusetts Institute of Technology), who will discuss systems analysis of cell communication network dynamics for therapeutic biologics design; David Baker (University of Washington), who will describe computer-based design of smart protein therapeutics; and William Schief (The Scripps Research Institute), who will discuss epitope-focused immunogen design.   In this preview of the conference, the workshop and session chairs share their thoughts on what conference participants may learn in sessions on: (1) three-dimensional structure antibody modeling; (2) identifying clonal lineages from next-generation data sets of expressed VH gene sequences; (3) antibodies in cardiometabolic medicine; (4) the effects of antibody gene variation and usage on the antibody response; (5) directed evolution; (6) antibody pharmacokinetics, distribution and off-target toxicity; (7) use of knowledge-based design to guide development of complementarity-determining regions and epitopes to engineer or elicit the desired antibody; (8) optimizing antibody formats for immunotherapy; (9) antibodies in a complex environment; (10) polyclonal, oligoclonal and bispecific antibodies; (11) antibodies to watch in 2014; and (12) polyreactive antibodies and polyspecificity.

  17. NABE Annual Conference Journal 1988-1989.

    ERIC Educational Resources Information Center

    Malave, Lilliam M., Ed.

    This document contains papers from two NABE annual conferences: (17th, Houston, Texas, April 27-May 1, 1988) and (18th, Miami, Florida, May 9-13, 1989). Papers cover three categories: (1) bilingual education and bilingualism: realities in the twentieth century; (2) current ideologies and models in bilingual education; and (3) effective…

  18. Mechanics of Textile Composites Conference. Part 1

    NASA Technical Reports Server (NTRS)

    Poe, Clarence C., Jr. (Editor); Harris, Charles E. (Editor)

    1995-01-01

    This document is a compilation of papers presented at the Mechanics of Textile Composites Conference in Hampton, Virginia, December 6-8, 1994. This conference was the culmination of a 3-year program that was initiated by NASA late in 1990 to develop mechanics of textile composites in support of the NASA Advanced Composites Technology Program (ACT). The goal of the program was to develop mathematical models of textile preform materials and test methods to facilitate structural analysis and design. Participants in the program were from NASA, academia, and industry.

  19. 41 CFR Appendix E to Chapter 301 - Suggested Guidance for Conference Planning

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... be conferences under 5 CFR 410.404. Conference lodging allowance: The rate that is up to 25 percent..., transportation, and other. • Accessibility by car or air. • Whether recreational activities are necessary. • The...? • Easily reached from an airport or by car? • Clean? • Well run, e.g., does the staff seem to be...

  20. 8th Spacecraft Charging Technology Conference

    NASA Technical Reports Server (NTRS)

    Minor, J. L. (Compiler)

    2004-01-01

    The 8th Spacecraft Charging Technology Conference was held in Huntsville, Alabama, October 20-24, 2003. Hosted by NASA s Space Environments and Effects (SEE) Program and co-sponsored by the Air Force Research Laboratory (AFRL) and the European Space Agency (ESA), the 2003 conference saw attendance from eleven countries with over 65 oral papers and 18 poster papers. Presentation topics highlighted the latest in spacecraft charging mitigation techniques and on-orbit investigations, including: Plasma Propulsion and Tethers; Ground Testing Techniques; Interactions of Spacecraft and Systems With the Natural and Induced Plasma Environment; Materials Characterizations; Models and Computer Simulations; Environment Specifications; Current Collection and Plasma Probes in Space Plasmas; On-Orbit Investigations. A round-table discussion of international standards regarding electrostatic discharge (ESD) testing was also held with the promise of continued discussions in the off years and an official continuation at the next conference.

  1. The 50th Annual Maize Genetics Conference

    SciTech Connect

    Cone, Karen

    2014-03-26

    The 50th Annual Maize Genetics Conference was held February 27 - March 2, 2008 at the Marriott Wardman Park Hotel in Washington, D.C. As the golden anniversary of the Conference and coinciding with the release of a draft of the maize genome sequence, this was a special meeting. To publicize this unique occasion, meeting organizers hosted a press conference, which was attended by members of the press representing science and non-science publications, and an evening reception at the Smithsonian National Museum of Natural History, where the draft sequence was announced and awards were presented to Dr. Mary Clutter and Senator Kit Bond to thank them for their outstanding contributions to maize genetics and genomics research. As usual, the Conference provided an invigorating forum for exchange of recent research results in many areas of maize genetics, e.g., cytogenetics, development, molecular genetics, transposable element biology, biochemical genetics, and genomics. Results were shared via both oral and poster presentations. Invited talks were given by four distinguished geneticists: Vicki Chandler, University of Arizona; John Doebley, University of Wisconsin; Susan Wessler, University of Georgia; and Richard Wilson, Washington University. There were 46 short talks and 241 poster presentations. The Conference was attended by over 500 participants. This included a large number of first-time participants in the meeting and an increasingly visible presence by individuals from underrepresented groups. Although we do not have concrete counts, there seem to be more African American, African and Hispanic/Latino attendees coming to the meeting than in years past. In addition, this meeting attracted many participants from outside the U.S. Student participation continues to be hallmark of the spirit of free exchange and cooperation characteristic of the maize genetics community. With the generous support provided by DOE, USDA NSF, and corporate/private donors, organizers were

  2. Does rational selection of training and test sets improve the outcome of QSAR modeling?

    PubMed

    Martin, Todd M; Harten, Paul; Young, Douglas M; Muratov, Eugene N; Golbraikh, Alexander; Zhu, Hao; Tropsha, Alexander

    2012-10-22

    Prior to using a quantitative structure activity relationship (QSAR) model for external predictions, its predictive power should be established and validated. In the absence of a true external data set, the best way to validate the predictive ability of a model is to perform its statistical external validation. In statistical external validation, the overall data set is divided into training and test sets. Commonly, this splitting is performed using random division. Rational splitting methods can divide data sets into training and test sets in an intelligent fashion. The purpose of this study was to determine whether rational division methods lead to more predictive models compared to random division. A special data splitting procedure was used to facilitate the comparison between random and rational division methods. For each toxicity end point, the overall data set was divided into a modeling set (80% of the overall set) and an external evaluation set (20% of the overall set) using random division. The modeling set was then subdivided into a training set (80% of the modeling set) and a test set (20% of the modeling set) using rational division methods and by using random division. The Kennard-Stone, minimal test set dissimilarity, and sphere exclusion algorithms were used as the rational division methods. The hierarchical clustering, random forest, and k-nearest neighbor (kNN) methods were used to develop QSAR models based on the training sets. For kNN QSAR, multiple training and test sets were generated, and multiple QSAR models were built. The results of this study indicate that models based on rational division methods generate better statistical results for the test sets than models based on random division, but the predictive power of both types of models are comparable.

  3. When does familiarity promote versus undermine interpersonal attraction? A proposed integrative model from erstwhile adversaries.

    PubMed

    Finkel, Eli J; Norton, Michael I; Reis, Harry T; Ariely, Dan; Caprariello, Peter A; Eastwick, Paul W; Frost, Jeana H; Maniaci, Michael R

    2015-01-01

    This article began as an adversarial collaboration between two groups of researchers with competing views on a longstanding question: Does familiarity promote or undermine interpersonal attraction? As we explored our respective positions, it became clear that the limitations of our conceptualizations of the familiarity-attraction link, as well as the limitations of prior research, were masking a set of higher order principles capable of integrating these diverse conceptualizations. This realization led us to adopt a broader perspective, which focuses on three distinct relationship stages-awareness, surface contact, and mutuality-and suggests that the influence of familiarity on attraction depends on both the nature and the stage of the relationship between perceivers and targets. This article introduces the framework that emerged from our discussions and suggests directions for research to investigate its validity. PMID:25910379

  4. The DOE Accelerated Strategic Computing Initiative: Enabling the tools for predictive materials modeling and simulation

    NASA Astrophysics Data System (ADS)

    Mailhiot, Christian

    1997-08-01

    The objective of the DOE Science-Based Stockpile Stewardship (SBSS) program is to ensure confidence in the performance, safety, and reliability of the U.S. nuclear stockpile on the basis of a vigorous science-based approach without nuclear testing, in compliance with the comprehensive test-ban treaty. A critical element of this approach is the development of predictive, first-principles, full-physics computer simulation tools. In support of the SBSS program, the DOE has launched the Accelerated Strategic Computing Initiative (ASCI) to enable these computational developments and to promptly shift from an \\underlineempirical test-based methodology to a \\underlinepredictive simulation-based approach. In particular, the development of advanced materials simulation capabilities to predict the effects of materials properties -- as these properties change as a result of aging and/or re-manufacturing -- on stockpile performance has explicitly been identified as one of the most critical component of the SBSS program. Consequently, the emerging SBSS program at the national laboratories presents unprecedented opportunities and challenges for solving important materials physics problems of significance to national security. A key element in the development of predictive materials simulation capabilities is the establishment of rigorous theoretical links between ab initio quantum-based descriptions at the electronic and atomic levels and engineering continuum-based treatments at the macroscopic scale. These links can be established through the identification of the appropriate degrees of freedom which determine the materials response. Applications which illustrate the use of advanced materials simulation methods for the prediction of the thermodynamical and mechanical properties of materials as they afford to bridge the length-scale gap between different levels of descriptions will be presented.

  5. Where does the uncertainty come from? Attributing Uncertainty in Conceptual Hydrologic Modelling

    NASA Astrophysics Data System (ADS)

    Abu Shoaib, S.; Marshall, L. A.; Sharma, A.

    2015-12-01

    Defining an appropriate forecasting model is a key phase in water resources planning and design. Quantification of uncertainty is an important step in the development and application of hydrologic models. In this study, we examine the dependency of hydrologic model uncertainty on the observed model inputs, defined model structure, parameter optimization identifiability and identified likelihood. We present here a new uncertainty metric, the Quantile Flow Deviation or QFD, to evaluate the relative uncertainty due to each of these sources under a range of catchment conditions. Through the metric, we may identify the potential spectrum of uncertainty and variability in model simulations. The QFD assesses uncertainty by estimating the deviation in flows at a given quantile across a range of scenarios. By using a quantile based metric, the change in uncertainty across individual percentiles can be assessed, thereby allowing uncertainty to be expressed as a function of time. The QFD method can be disaggregated to examine any part of the modelling process including the selection of certain model subroutines or forcing data. Case study results (including catchments in Australia and USA) suggest that model structure selection is vital irrespective of the flow percentile of interest or the catchment being studied. Examining the QFD across various quantiles additionally demonstrates that lower yielding catchments may have greater variation due to selected model structures. By incorporating multiple model structures, it is possible to assess (i) the relative importance of various sources of uncertainty, (ii) how these vary with the change in catchment location or hydrologic regime; and (iii) the impact of the length of available observations in uncertainty quantification.

  6. The lure of rationality: Why does the deficit model persist in science communication?

    PubMed

    Simis, Molly J; Madden, Haley; Cacciatore, Michael A; Yeo, Sara K

    2016-05-01

    Science communication has been historically predicated on the knowledge deficit model. Yet, empirical research has shown that public communication of science is more complex than what the knowledge deficit model suggests. In this essay, we pose four lines of reasoning and present empirical data for why we believe the deficit model still persists in public communication of science. First, we posit that scientists' training results in the belief that public audiences can and do process information in a rational manner. Second, the persistence of this model may be a product of current institutional structures. Many graduate education programs in science, technology, engineering, and math (STEM) fields generally lack formal training in public communication. We offer empirical evidence that demonstrates that scientists who have less positive attitudes toward the social sciences are more likely to adhere to the knowledge deficit model of science communication. Third, we present empirical evidence of how scientists conceptualize "the public" and link this to attitudes toward the deficit model. We find that perceiving a knowledge deficit in the public is closely tied to scientists' perceptions of the individuals who comprise the public. Finally, we argue that the knowledge deficit model is perpetuated because it can easily influence public policy for science issues. We propose some ways to uproot the deficit model and move toward more effective science communication efforts, which include training scientists in communication methods grounded in social science research and using approaches that engage community members around scientific issues. PMID:27117768

  7. Does Rational Selection of Training and Test Sets Improve the Outcome of QSAR Modeling?

    EPA Science Inventory

    Prior to using a quantitative structure activity relationship (QSAR) model for external predictions, its predictive power should be established and validated. In the absence of a true external dataset, the best way to validate the predictive ability of a model is to perform its s...

  8. Does the abundance of hoverfly (Syrphidae) mimics depend on the numbers of their hymenopteran models?

    PubMed

    Howarth, Brigitte; Edmunds, Malcolm; Gilbert, Francis

    2004-02-01

    We tested the prediction that, if hoverflies are Batesian mimics, this may extend to behavioral mimicry such that their numerical abundance at each hour of the day (the daily activity pattern) is related to the numbers of their hymenopteran models. After accounting for site, season, microclimatic responses, and general hoverfly abundance at three sites in northwestern England, the residual numbers of mimics were significantly correlated positively with their models nine times of 17. Sixteen of 17 relationships were positive, itself a highly significant nonrandom pattern. Several eristaline flies showed significant relationships with honeybees even though some of them mimic wasps or bumblebees, perhaps reflecting an ancestral resemblance to honeybees. There was no evidence that good and poor mimics differed in their daily activity pattern relationships with models. However, the common mimics showed significant activity pattern relationships with their models, whereas the rarer mimics did not. We conclude that many hoverflies show behavioral mimicry of their hymenopteran models.

  9. The 1991 International Aerospace and Ground Conference on Lightning and Static Electricity, volume 2

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The proceedings of the conference are reported. The conference focussed on lightning protection, detection, and forecasting. The conference was divided into 26 sessions based on research in lightning, static electricity, modeling, and mapping. These sessions spanned the spectrum from basic science to engineering, concentrating on lightning prediction and detection and on safety for ground facilities, aircraft, and aerospace vehicles.

  10. Does a peer model's task proficiency influence children's solution choice and innovation?

    PubMed

    Wood, Lara A; Kendal, Rachel L; Flynn, Emma G

    2015-11-01

    The current study investigated whether 4- to 6-year-old children's task solution choice was influenced by the past proficiency of familiar peer models and the children's personal prior task experience. Peer past proficiency was established through behavioral assessments of interactions with novel tasks alongside peer and teacher predictions of each child's proficiency. Based on these assessments, one peer model with high past proficiency and one age-, sex-, dominance-, and popularity-matched peer model with lower past proficiency were trained to remove a capsule using alternative solutions from a three-solution artificial fruit task. Video demonstrations of the models were shown to children after they had either a personal successful interaction or no interaction with the task. In general, there was not a strong bias toward the high past-proficiency model, perhaps due to a motivation to acquire multiple methods and the salience of other transmission biases. However, there was some evidence of a model-based past-proficiency bias; when the high past-proficiency peer matched the participants' original solution, there was increased use of that solution, whereas if the high past-proficiency peer demonstrated an alternative solution, there was increased use of the alternative social solution and novel solutions. Thus, model proficiency influenced innovation. PMID:26143092

  11. One size does not fit all: Adapting mark-recapture and occupancy models for state uncertainty

    USGS Publications Warehouse

    Kendall, W.L.; Thomson, David L.; Cooch, Evan G.; Conroy, Michael J.

    2009-01-01

    Multistate capture?recapture models continue to be employed with greater frequency to test hypotheses about metapopulation dynamics and life history, and more recently disease dynamics. In recent years efforts have begun to adjust these models for cases where there is uncertainty about an animal?s state upon capture. These efforts can be categorized into models that permit misclassification between two states to occur in either direction or one direction, where state is certain for a subset of individuals or is always uncertain, and where estimation is based on one sampling occasion per period of interest or multiple sampling occasions per period. State uncertainty also arises in modeling patch occupancy dynamics. I consider several case studies involving bird and marine mammal studies that illustrate how misclassified states can arise, and outline model structures for properly utilizing the data that are produced. In each case misclassification occurs in only one direction (thus there is a subset of individuals or patches where state is known with certainty), and there are multiple sampling occasions per period of interest. For the cases involving capture?recapture data I allude to a general model structure that could include each example as a special case. However, this collection of cases also illustrates how difficult it is to develop a model structure that can be directly useful for answering every ecological question of interest and account for every type of data from the field.

  12. Does including physiology improve species distribution model predictions of responses to recent climate change?

    PubMed

    Buckley, Lauren B; Waaser, Stephanie A; MacLean, Heidi J; Fox, Richard

    2011-12-01

    Thermal constraints on development are often invoked to predict insect distributions. These constraints tend to be characterized in species distribution models (SDMs) by calculating development time based on a constant lower development temperature (LDT). Here, we assessed whether species-specific estimates of LDT based on laboratory experiments can improve the ability of SDMs to predict the distribution shifts of six U.K. butterflies in response to recent climate warming. We find that species-specific and constant (5 degrees C) LDT degree-day models perform similarly at predicting distributions during the period of 1970-1982. However, when the models for the 1970-1982 period are projected to predict distributions in 1995-1999 and 2000-2004, species-specific LDT degree-day models modestly outperform constant LDT degree-day models. Our results suggest that, while including species-specific physiology in correlative models may enhance predictions of species' distribution responses to climate change, more detailed models may be needed to adequately account for interspecific physiological differences. PMID:22352161

  13. Does planetary temperature fundamentally affect water availability on land? An idealized modeling study

    NASA Astrophysics Data System (ADS)

    Scheff, J.; Frierson, D. M.

    2013-12-01

    The geologic and paleobotanical record is usually said to show that during warm greenhouse climates of Earth's past, moisture for plant growth was at least as plentiful as it is today in most land areas. Similarly, very cold glacial stages are usually interpreted as times of water scarcity, outside of a few small regions. Yet, for the warm greenhouse climates of Earth's near future, comprehensive models largely project declines in time-mean soil moisture, and increases in physical drought and aridity measures. This study attempts to understand these projections by using a simple, general, idealized land model coupled to a global atmosphere model (GFDL AM2.1) and a slab ocean. The model is run to equilibrium over a wide range of planetary temperatures, and the responses of land hydroclimates are examined. In particular, several different dimensionless water-scarcity metrics are tracked, including near-surface relative humidity, ratios between precipitation, actual and potential evapotranspiration, and the percent of maximum soil moisture. These experiments are performed for a very wide range of land model parameters, atmospheric parameterizations, idealized continent geometries, prescribed ocean heat transport fields, astronomical boundary conditions, and temperature change mechanisms. If dimensionless water availability systematically declines with increasing planetary temperature regardless of these choices, then the model result might be viewed as robust. However, if certain modeling choices, metrics, and/or regions indicate the opposite behavior, in line with the geologic record, then the results could greatly aid in the interpretation of that record.

  14. Measuring the Effectiveness of a Genetic Counseling Supervision Training Conference.

    PubMed

    Atzinger, Carrie L; He, Hua; Wusik, Katie

    2016-08-01

    Genetic counselors who receive formal training report increased confidence and competence in their supervisory roles. The effectiveness of specific formal supervision training has not been assessed previously. A day-long GC supervision conference was designed based on published supervision competencies and was attended by 37 genetic counselors. Linear Mixed Model and post-hoc paired t-test was used to compare Psychotherapy Supervisor Development Scale (PSDS) scores among/between individuals pre and post conference. Generalized Estimating Equation (GEE) model and post-hoc McNemar's test was used to determine if the conference had an effect on GC supervision competencies. PSDS scores were significantly increased 1 week (p < 0.001) and 6 months (p < 0.001) following the conference. For three supervision competencies, attendees were more likely to agree they were able to perform them after the conference than before. These effects remained significant 6 months later. For the three remaining competencies, the majority of supervisors agreed they could perform these before the conference; therefore, no change was found. This exploratory study showed this conference increased the perceived confidence and competence of the supervisors who attended and increased their self-reported ability to perform certain supervision competencies. While still preliminary, this supports the idea that a one day conference on supervision has the potential to impact supervisor development.

  15. IEEE conference record -- Abstracts

    SciTech Connect

    Not Available

    1994-01-01

    This conference covers the following areas: computational plasma physics; vacuum electronic; basic phenomena in fully ionized plasmas; plasma, electron, and ion sources; environmental/energy issues in plasma science; space plasmas; plasma processing; ball lightning/spherical plasma configurations; plasma processing; fast wave devices; magnetic fusion; basic phenomena in partially ionized plasma; dense plasma focus; plasma diagnostics; basic phenomena in weakly ionized gases; fast opening switches; MHD; fast z-pinches and x-ray lasers; intense ion and electron beams; laser-produced plasmas; microwave plasma interactions; EM and ETH launchers; solid state plasmas and switches; intense beam microwaves; and plasmas for lighting. Separate abstracts were prepared for 416 papers in this conference.

  16. Metabolic Engineering VII Conference

    SciTech Connect

    Kevin Korpics

    2012-12-04

    The aims of this Metabolic Engineering conference are to provide a forum for academic and industrial researchers in the field; to bring together the different scientific disciplines that contribute to the design, analysis and optimization of metabolic pathways; and to explore the role of Metabolic Engineering in the areas of health and sustainability. Presentations, both written and oral, panel discussions, and workshops will focus on both applications and techniques used for pathway engineering. Various applications including bioenergy, industrial chemicals and materials, drug targets, health, agriculture, and nutrition will be discussed. Workshops focused on technology development for mathematical and experimental techniques important for metabolic engineering applications will be held for more in depth discussion. This 2008 meeting will celebrate our conference tradition of high quality and relevance to both industrial and academic participants, with topics ranging from the frontiers of fundamental science to the practical aspects of metabolic engineering.

  17. NSI conference support

    NASA Technical Reports Server (NTRS)

    Aaron, Susan

    1991-01-01

    One of the many services NSI provides as an extension of customer/user support is to attend major scientific conferences. The conference effort provides NASA/OSSA scientists with many benefits: (1) scientist get to see NSI in action; they utilize the network to read email, and have recently begun to demonstrate their scientific research to their colleagues; (2) scientist get an opportunity to meet and interact with NSI Staff, which gives scientists a chance to get status on their requirements, ask about network status, get acquainted with our procedures, and learn about services; and (3) scientists are exposed to networking in a larger sense; particularly by knowing about other NASA groups who provide valuable scientific resources over the Internet.

  18. 9th International Conference on Dense Z-Pinches

    SciTech Connect

    Bott-Suzuki, Simon

    2015-08-31

    DOE OFES supported the 9th International Conference on Z-Pinches (DZP 2014) held in Napa, CA in August 2014. Funds were used to support travel for several US students, and to disseminate information through the publication of a proceedings volume.

  19. Who does it better? The corporate versus the nonprofit governance model.

    PubMed

    Larson, Laurie

    2005-05-01

    Weighing the corporate against the nonprofit governance model, the answer may be "neither." Both systems can learn from each other, experts say, and best practices in public companies do not automatically translate to health care boards. PMID:15926295

  20. Does the first chaotic inflation model in supergravity provide the best fit to the Planck data?

    SciTech Connect

    Linde, Andrei

    2015-02-23

    I describe the first model of chaotic inflation in supergravity, which was proposed by Goncharov and the present author in 1983. The inflaton potential of this model has a plateau-type behavior V{sub 0}(1−(8/3) e{sup −√6|ϕ|}) at large values of the inflaton field. This model predicts n{sub s}=1−(2/N)≈0.967 and r=(4/(3N{sup 2}))≈4×10{sup −4}, in good agreement with the Planck data. I propose a slight generalization of this model, which allows to describe not only inflation but also dark energy and supersymmetry breaking.

  1. Who does it better? The corporate versus the nonprofit governance model.

    PubMed

    Larson, Laurie

    2005-05-01

    Weighing the corporate against the nonprofit governance model, the answer may be "neither." Both systems can learn from each other, experts say, and best practices in public companies do not automatically translate to health care boards.

  2. Final technical report for DOE Computational Nanoscience Project: Integrated Multiscale Modeling of Molecular Computing Devices

    SciTech Connect

    Cummings, P. T.

    2010-02-08

    This document reports the outcomes of the Computational Nanoscience Project, "Integrated Multiscale Modeling of Molecular Computing Devices". It includes a list of participants and publications arising from the research supported.

  3. How Does Knowing Snowpack Distribution Help Model Calibration and Reservoir Management?

    NASA Astrophysics Data System (ADS)

    Graham, C. B.; Mazurkiewicz, A.; McGurk, B. J.; Painter, T. H.

    2014-12-01

    Well calibrated hydrologic models are a necessary tool for reservoir managers to meet increasingly complicated regulatory, environmental and consumptive demands on water supply systems. Achieving these objectives is difficult during periods of drought, such as seen in the Sierra Nevada in recent years. This emphasizes the importance of accurate watershed modeling and forecasting of runoff. While basin discharge has traditionally been the main criteria for model calibration, many studies have shown it to be a poor control on model calibration where correct understanding of the subbasin hydrologic processes are required. Additional data sources such as snowpack accumulation and melt are often required to create a reliable model calibration. When allocating resources for monitoring snowpack conditions, water system managers often must choose between monitoring point locations at high temporal resolution (i.e. real time weather and snow monitoring stations) and large spatial surveys (i.e. remote sensing). NASA's Airborne Snow Observatory (ASO) provides a unique opportunity to test the relative value of spatially dense, temporally sparse measurements vs. temporally dense, spatially sparse measurements for hydrologic model calibration. The ASO is a demonstration mission using coupled LiDAR and imaging spectrometer mounted to an aircraft flying at 6100 m to collect high spatial density measurements of snow water content and albedo over the 1189 km2 Tuolumne River Basin. Snow depth and albedo were collected weekly throughout the snowmelt runoff period at 5 m2 resolution during the 2013-2014 snowmelt. We developed an implementation of the USGS Precipitation Runoff Modeling System (PRMS) for the Tuolumne River above Hetch Hetchy Reservoir, the primary water source for San Francisco. The modeled snow accumulation and ablation was calibrated in 2 models using either 2 years of weekly measurements of distributed snow water equivalent from the ASO, or 2 years of 15 minute snow

  4. Models of Verbal Working Memory Capacity: What Does It Take to Make Them Work?

    PubMed Central

    Cowan, Nelson; Rouder, Jeffrey N.; Blume, Christopher L.; Saults, J. Scott

    2013-01-01

    Theories of working memory (WM) capacity limits will be more useful when we know what aspects of performance are governed by the limits and what aspects are governed by other memory mechanisms. Whereas considerable progress has been made on models of WM capacity limits for visual arrays of separate objects, less progress has been made in understanding verbal materials, especially when words are mentally combined to form multi-word units or chunks. Toward a more comprehensive theory of capacity limits, we examine models of forced-choice recognition of words within printed lists, using materials designed to produce multi-word chunks in memory (e.g., leather brief case). Several simple models were tested against data from a variety of list lengths and potential chunk sizes, with test conditions that only imperfectly elicited the inter-word associations. According to the most successful model, participants retained about 3 chunks on average in a capacity-limited region of WM, with some chunks being only subsets of the presented associative information (e.g., leather brief case retained with leather as one chunk and brief case as another). The addition to the model of an activated long-term memory (LTM) component unlimited in capacity was needed. A fixed capacity limit appears critical to account for immediate verbal recognition and other forms of WM. We advance a model-based approach that allows capacity to be assessed despite other important processing contributions. Starting with a psychological-process model of WM capacity developed to understand visual arrays, we arrive at a more unified and complete model. PMID:22486726

  5. Does the diffusion dark matter-dark energy interaction model solve cosmological puzzles?

    NASA Astrophysics Data System (ADS)

    Szydłowski, Marek; Stachowski, Aleksander

    2016-08-01

    We study dynamics of cosmological models with diffusion effects modeling dark matter and dark energy interactions. We show the simple model with diffusion between the cosmological constant sector and dark matter, where the canonical scaling law of dark matter (ρd m ,0a-3(t )) is modified by an additive ɛ (t )=γ t a-3(t ) to the form ρd m=ρd m ,0a-3(t )+ɛ (t ). We reduced this model to the autonomous dynamical system and investigate it using dynamical system methods. This system possesses a two-dimensional invariant submanifold on which the dark matter-dark energy (DM-DE) interaction can be analyzed on the phase plane. The state variables are density parameter for matter (dark and visible) and parameter δ characterizing the rate of growth of energy transfer between the dark sectors. A corresponding dynamical system belongs to a general class of jungle type of cosmologies represented by coupled cosmological models in a Lotka-Volterra framework. We demonstrate that the de Sitter solution is a global attractor for all trajectories in the phase space and there are two repellers: the Einstein-de Sitter universe and the de Sitter universe state dominating by the diffusion effects. We distinguish in the phase space trajectories, which become in good agreement with the data. They should intersect a rectangle with sides of Ωm ,0∈[0.2724 ,0.3624 ] , δ ∈[0.0000 ,0.0364 ] at the 95% CL. Our model could solve some of the puzzles of the Λ CDM model, such as the coincidence and fine-tuning problems. In the context of the coincidence problem, our model can explain the present ratio of ρm to ρd e, which is equal 0.457 6-0.0831+0.1109 at a 2 σ confidence level.

  6. Models of verbal working memory capacity: what does it take to make them work?

    PubMed

    Cowan, Nelson; Rouder, Jeffrey N; Blume, Christopher L; Saults, J Scott

    2012-07-01

    Theories of working memory (WM) capacity limits will be more useful when we know what aspects of performance are governed by the limits and what aspects are governed by other memory mechanisms. Whereas considerable progress has been made on models of WM capacity limits for visual arrays of separate objects, less progress has been made in understanding verbal materials, especially when words are mentally combined to form multiword units or chunks. Toward a more comprehensive theory of capacity limits, we examined models of forced-choice recognition of words within printed lists, using materials designed to produce multiword chunks in memory (e.g., leather brief case). Several simple models were tested against data from a variety of list lengths and potential chunk sizes, with test conditions that only imperfectly elicited the interword associations. According to the most successful model, participants retained about 3 chunks on average in a capacity-limited region of WM, with some chunks being only subsets of the presented associative information (e.g., leather brief case retained with leather as one chunk and brief case as another). The addition to the model of an activated long-term memory component unlimited in capacity was needed. A fixed-capacity limit appears critical to account for immediate verbal recognition and other forms of WM. We advance a model-based approach that allows capacity to be assessed despite other important processing contributions. Starting with a psychological-process model of WM capacity developed to understand visual arrays, we arrive at a more unified and complete model.

  7. Genome sequencing conference II

    SciTech Connect

    Not Available

    1990-01-01

    Genome Sequencing Conference 2 was held September 30 to October 30, 1990. 26 speaker abstracts and 33 poster presentations were included in the program report. New and improved methods for DNA sequencing and genetic mapping were presented. Many of the papers were concerned with accuracy and speed of acquisition of data with computers and automation playing an increasing role. Individual papers have been processed separately for inclusion on the database.

  8. Moldova. Historic regional conference.

    PubMed

    Moshin, V

    1995-05-01

    The Directorate of Maternal and Child Health and the Family Planning Association of Moldova organized a regional conference, which was held October 18-19, 1994, in Kishinev, Moldova, with the support of the United Nations Population Fund (UNFPA), the World Health Organization (WHO), and the International Planned Parenthood Federation (IPPF). The conference,"Problems of Family Planning in Eastern Europe," was attended by approximately 400 Moldovan delegates of governmental and nongovernmental organizations (NGOs), and by 25 delegates from Romania, Russia, Belarus, the Ukraine, and Georgia. The President of Moldova and the Ministry of Public Health of Moldova gave their approval. The main objectives of the conference were to inform the public about the recommendations of the ICPD, to analyze the status of women's reproductive health and family planning in Eastern Europe, and to find ways of implementing the ICPD Plan of Action. Major problems identified during the conference were: 1) the social and economic problems facing most families; 2) the high rate of morbidity and mortality; 3) the decrease in birth rate; 4) the increase in abortions; 5) the rising incidence of venereal disease; and 6) the absence of an effective family planning system. It was agreed that cooperation between governments and NGOs is essential in designing population programs for each country. The following goals were set: 1) to provide populations with sufficient contraceptives; 2) to actively promote family planning concepts through the mass media; 3) to train specialists and to open family planning offices and centers; 4) to introduce sex education in the curricula of Pedagogical Institutes; and 5) to create national and regional statistical and sociological databases on population issues.

  9. An experimental climate modeling laboratory. DOE CHAMMP Program, year 2 final report

    SciTech Connect

    1996-02-01

    The major focus of this two year duration CHAMMP science team project is the development and in-model testing of new numerical methods and dynamical algorithms which are particularly well suited to massively parallel computers. The project includes efforts relevant to both global ocean circulation models and atmospheric GCMs. During the course of the authors investigations they focused on two basic areas. The first of these was the implementation and testing of a global non-linear dynamics code using the Local Spectral (LS) formalism. The LS method is of considerable interest for atmospheric GCMs since it has a computational complexity of N{sup 2} as opposed to the N{sup 3} log N complexity of Spectral Transform (ST) implementations while maintaining many of the same properties of the ST models which have become the dominant method employed for global climate model studies. A second element of the investigation has been the evaluation of alternate dynamical systems for use in global ocean circulation models. Some of the investigations have focused on the use of split-explicit hydrostatic models while others have made use of non-hydrostatic dynamics with vertically implicit integrations of equation systems using artificial compressibility.

  10. A Cercla-Based Decision Model to Support Remedy Selection for an Uncertain Volume of Contaminants at a DOE Facility

    SciTech Connect

    Christine E. Kerschus

    1999-03-31

    The Paducah Gaseous Diffusion Plant (PGDP) operated by the Department of Energy is challenged with selecting the appropriate remediation technology to cleanup contaminants at Waste Area Group (WAG) 6. This research utilizes value-focused thinking and multiattribute preference theory concepts to produce a decision analysis model designed to aid the decision makers in their selection process. The model is based on CERCLA's five primary balancing criteria, tailored specifically to WAG 6 and the contaminants of concern, utilizes expert opinion and the best available engineering, cost, and performance data, and accounts for uncertainty in contaminant volume. The model ranks 23 remediation technologies (trains) in their ability to achieve the CERCLA criteria at various contaminant volumes. A sensitivity analysis is performed to examine the effects of changes in expert opinion and uncertainty in volume. Further analysis reveals how volume uncertainty is expected to affect technology cost, time and ability to meet the CERCLA criteria. The model provides the decision makers with a CERCLA-based decision analysis methodology that is objective, traceable, and robust to support the WAG 6 Feasibility Study. In addition, the model can be adjusted to address other DOE contaminated sites.

  11. How does observation uncertainty influence which stream water samples are most informative for model calibration?

    NASA Astrophysics Data System (ADS)

    Wang, Ling; van Meerveld, Ilja; Seibert, Jan

    2016-04-01

    Streamflow isotope samples taken during rainfall-runoff events are very useful for multi-criteria model calibration because they can help decrease parameter uncertainty and improve internal model consistency. However, the number of samples that can be collected and analysed is often restricted by practical and financial constraints. It is, therefore, important to choose an appropriate sampling strategy and to obtain samples that have the highest information content for model calibration. We used the Birkenes hydrochemical model and synthetic rainfall, streamflow and isotope data to explore which samples are most informative for model calibration. Starting with error-free observations, we investigated how many samples are needed to obtain a certain model fit. Based on different parameter sets, representing different catchments, and different rainfall events, we also determined which sampling times provide the most informative data for model calibration. Our results show that simulation performance for models calibrated with the isotopic data from two intelligently selected samples was comparable to simulations based on isotopic data for all 100 time steps. The models calibrated with the intelligently selected samples also performed better than the model calibrations with two benchmark sampling strategies (random selection and selection based on hydrologic information). Surprisingly, samples on the rising limb and at the peak were less informative than expected and, generally, samples taken at the end of the event were most informative. The timing of the most informative samples depends on the proportion of different flow components (baseflow, slow response flow, fast response flow and overflow). For events dominated by baseflow and slow response flow, samples taken at the end of the event after the fast response flow has ended were most informative; when the fast response flow was dominant, samples taken near the peak were most informative. However when overflow

  12. Does Imaging Technology Cause Cancer? Debunking the Linear No-Threshold Model of Radiation Carcinogenesis.

    PubMed

    Siegel, Jeffry A; Welsh, James S

    2016-04-01

    In the past several years, there has been a great deal of attention from the popular media focusing on the alleged carcinogenicity of low-dose radiation exposures received by patients undergoing medical imaging studies such as X-rays, computed tomography scans, and nuclear medicine scintigraphy. The media has based its reporting on the plethora of articles published in the scientific literature that claim that there is "no safe dose" of ionizing radiation, while essentially ignoring all the literature demonstrating the opposite point of view. But this reported "scientific" literature in turn bases its estimates of cancer induction on the linear no-threshold hypothesis of radiation carcinogenesis. The use of the linear no-threshold model has yielded hundreds of articles, all of which predict a definite carcinogenic effect of any dose of radiation, regardless of how small. Therefore, hospitals and professional societies have begun campaigns and policies aiming to reduce the use of certain medical imaging studies based on perceived risk:benefit ratio assumptions. However, as they are essentially all based on the linear no-threshold model of radiation carcinogenesis, the risk:benefit ratio models used to calculate the hazards of radiological imaging studies may be grossly inaccurate if the linear no-threshold hypothesis is wrong. Here, we review the myriad inadequacies of the linear no-threshold model and cast doubt on the various studies based on this overly simplistic model.

  13. Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models.

    PubMed

    Singh, Mallika; Couto, Suzana S; Forrest, William F; Lima, Anthony; Cheng, Jason H; Molina, Rafael; Long, Jason E; Hamilton, Patricia; McNutt, Angela; Kasman, Ian; Nannini, Michelle A; Reslan, Hani Bou; Cao, Tim C; Ho, Calvin C K; Barck, Kai H; Carano, Richard A D; Foreman, Oded; Eastham-Anderson, Jeffrey; Jubb, Adrian M; Ferrara, Napoleone; Johnson, Leisa

    2012-08-01

    Resistance to anti-angiogenic therapy can occur via several potential mechanisms. Unexpectedly, recent studies showed that short-term inhibition of either VEGF or VEGFR enhanced tumour invasiveness and metastatic spread in preclinical models. In an effort to evaluate the translational relevance of these findings, we examined the consequences of long-term anti-VEGF monoclonal antibody therapy in several well-validated genetically engineered mouse tumour models of either neuroendocrine or epithelial origin. Anti-VEGF therapy decreased tumour burden and increased overall survival, either as a single agent or in combination with chemotherapy, in all four models examined. Importantly, neither short- nor long-term exposure to anti-VEGF therapy altered the incidence of metastasis in any of these autochthonous models, consistent with retrospective analyses of clinical trials. In contrast, we observed that sunitinib treatment recapitulated previously reported effects on tumour invasiveness and metastasis in a pancreatic neuroendocrine tumour (PNET) model. Consistent with these results, sunitinib treatment resulted in an up-regulation of the hypoxia marker GLUT1 in PNETs, whereas anti-VEGF did not. These results indicate that anti-VEGF mediates anti-tumour effects and therapeutic benefits without a paradoxical increase in metastasis. Moreover, these data underscore the concept that drugs targeting VEGF ligands and receptors may affect tumour metastasis in a context-dependent manner and are mechanistically distinct from one another.

  14. Does Don Fisher's high-pressure manifold model account for phloem transport and resource partitioning?

    PubMed Central

    Patrick, John W.

    2013-01-01

    The pressure flow model of phloem transport envisaged by Münch (1930) has gained wide acceptance. Recently, however, the model has been questioned on structural and physiological grounds. For instance, sub-structures of sieve elements may reduce their hydraulic conductances to levels that impede flow rates of phloem sap and observed magnitudes of pressure gradients to drive flow along sieve tubes could be inadequate in tall trees. A variant of the Münch pressure flow model, the high-pressure manifold model of phloem transport introduced by Donald Fisher may serve to reconcile at least some of these questions. To this end, key predicted features of the high-pressure manifold model of phloem transport are evaluated against current knowledge of the physiology of phloem transport. These features include: (1) An absence of significant gradients in axial hydrostatic pressure in sieve elements from collection to release phloem accompanied by transport properties of sieve elements that underpin this outcome; (2) Symplasmic pathways of phloem unloading into sink organs impose a major constraint over bulk flow rates of resources translocated through the source-path-sink system; (3) Hydraulic conductances of plasmodesmata, linking sieve elements with surrounding phloem parenchyma cells, are sufficient to support and also regulate bulk flow rates exiting from sieve elements of release phloem. The review identifies strong circumstantial evidence that resource transport through the source-path-sink system is consistent with the high-pressure manifold model of phloem transport. The analysis then moves to exploring mechanisms that may link demand for resources, by cells of meristematic and expansion/storage sinks, with plasmodesmal conductances of release phloem. The review concludes with a brief discussion of how these mechanisms may offer novel opportunities to enhance crop biomass yields. PMID:23802003

  15. 2012 MICROBIAL STRESS RESPONSE GORDON RESEARCH CONFERENCE, JULY 20-25, 2012

    SciTech Connect

    Timothy Donohue

    2012-07-25

    The Gordon Research Conference on MICROBIAL STRESS RESPONSE was held at Mount Holyoke College, South Hadley, Massachusetts, July 15-20, 2012. The Conference was well-attended with 180 participants. The 2012 Microbial Stress Responses Gordon Research Conference will provide a forum for the open reporting of recent discoveries on the diverse mechanisms employed by microbes to respond to stress. Approaches range from analysis at the molecular level (how are signals perceived and transmitted to change gene expression or function) to cellular and microbial community responses. Gordon Research Conferences does not permit publication of meeting proceedings.

  16. Twenty-First Annual Conference on Manual Control

    NASA Technical Reports Server (NTRS)

    Miller, R. A. (Compiler); Jagacinski, R. J. (Compiler)

    1986-01-01

    The proceedings of the entitled conference are presented. Twenty-nine manuscripts and eight abstracts pertaining to workload, attention and errors, controller evaluation, movement skills, coordination and decision making, display evaluation and human operator modeling and manual control.

  17. Proceedings of the 9th Annual Conference on Manual Control

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Papers are reported which were presented at the conference in the areas of displays, ride qualities and handling, driving and psychomotor skills, control, system identification and signal detection, electrophysiological and systems analysis, and modelling.

  18. Conference on Geospatial Approaches to Cancer Control and Population Sciences

    Cancer.gov

    The purpose of this conference is to bring together a community of researchers across the cancer control continuum using geospatial tools, models and approaches to address cancer prevention and control.

  19. Albumin infusion in humans does not model exercise induced hypervolaemia after 24 hours

    NASA Technical Reports Server (NTRS)

    Haskell, A.; Gillen, C. M.; Mack, G. W.; Nadel, E. R.

    1998-01-01

    We rapidly infused 234 +/- 3 mL of 5% human serum albumin in eight men while measuring haematocrit, haemoglobin concentration, plasma volume (PV), albumin concentration, total protein concentration, osmolality, sodium concentration, renin activity, aldosterone concentration, and atrial natriuretic peptide concentration to test the hypotheses that plasma volume expansion and plasma albumin content expansion will not persist for 24 h. Plasma volume and albumin content were expanded for the first 6 h after infusion (44.3 +/- 1.9-47.2 +/- 2.0 mL kg-1 and 1.9 +/- 0.1-2.1 +/- 0.1 g kg-1 at pre-infusion and 1 h, respectively, P < 0.05), but by 24 h plasma volume and albumin content decreased significantly from 1 h post-infusion and were not different from pre-infusion (44.8 +/- 1.9 mL kg-1 and 1.9 +/- 0.1 g kg-1, respectively). Plasma aldosterone concentration showed a significant effect of time over the 24 h after infusion (P < 0.05), and showed a trend to decrease at 2 h after infusion (167.6 +/- 32.5(-1) 06.2 +/- 13.4 pg mL-1, P = 0.07). These data demonstrate that a 6.8% expansion of plasma volume and 10.5% expansion of plasma albumin content by infusion does not remain in the vascular space for 24 h and suggest a redistribution occurs between the intravascular space and interstitial fluid space.

  20. Cyclooxygenase-2 inhibition does not impair block bone grafts healing in rabbit model.

    PubMed

    Moreschi, Eduardo; Biguetti, Claudia Cristina; Comparim, Eliston; De Andrade Holgado, Leandro; Ribeiro-Junior, Paulo Domingos; Nary-Filho, Hugo; Matsumoto, Mariza Akemi

    2013-12-01

    Success of alveolar reconstructions using onlay autogenous block bone grafts depends on their adequate integration to the recipient bed influenced by a number of local molecules. Considering the fundamental role of cyclooxygenase (COX-2) in bone repair, the aim of this study was to analyze the effect of its inhibition in the integration of endochondral (EC) iliac crest, and intramembranous (IM) calvaria bone grafts. Thirty-two rabbits were divided into 4 groups: Calvaria Control (CC) and Iliac Control--treated with oral 0.9 % saline solution, and Calvarial-NSAID (C-NSAID) and Iliac-NSAID (I-NSAID) groups--treated with oral 6 mg/Kg non-steroidal anti-inflammatory drug etoricoxib. After 7, 14, 30 and 60 days the animals were euthanized and the specimens removed for histological, histomorphometric and immunohistochemistry analysis. At day 60, a tight integration of IM blocks could be seen with the presence of remodeling bone, whereas integration of EC grafts was mainly observed at the edges of the grafts. A significant higher percentage of bone matrix in the interface region of the CC grafts in comparison to C-NSAID only at day 14, whereas no differences were detected comparing the EC grafts. No differences were observed in Runx-2 and vascular endothelial growth factor (VEGF) immunolabeling when comparing CC and C-NSAID groups, while a significant weaker Runx-2 and VEGF labeling was detected in I-NSAID group at day 60. Although some influence was detected in osteogenesis, it is concluded that drug induced inhibition of COX-2 does not impair onlay bone grafts' healing of both embryologic origins in rabbits. PMID:23783533

  1. What Does It Mean to Be Pragmatic? Pragmatic Methods, Measures, and Models to Facilitate Research Translation

    ERIC Educational Resources Information Center

    Glasgow, Russell E.

    2013-01-01

    Background: One of the reasons for the slow and uncertain translation of research into practice is likely due to the emphasis in science on explanatory models and efficacy designs rather than more pragmatic approaches. Methods: Following a brief definition of what constitutes a pragmatic approach, I provide examples of pragmatic methods, measures,…

  2. Models of Verbal Working Memory Capacity: What Does It Take to Make Them Work?

    ERIC Educational Resources Information Center

    Cowan, Nelson; Rouder, Jeffrey N.; Blume, Christopher L.; Saults, J. Scott

    2012-01-01

    Theories of working memory (WM) capacity limits will be more useful when we know what aspects of performance are governed by the limits and what aspects are governed by other memory mechanisms. Whereas considerable progress has been made on models of WM capacity limits for visual arrays of separate objects, less progress has been made in…

  3. A Latent Growth Model Suggests that Empathy of Medical Students Does Not Decline over Time

    ERIC Educational Resources Information Center

    Costa, Patrício; Magalhães, Eunice; Costa, Manuel João

    2013-01-01

    Empathy is a relevant attribute in the context of patient care. However, a decline in empathy throughout medical education has been reported in North-American medical schools, particularly, in the transition to clinical training. The present study aims to longitudinally model empathy during medical school at three time points: at the entrance,…

  4. Two Models of Raters in a Structured Oral Examination: Does It Make a Difference?

    ERIC Educational Resources Information Center

    Touchie, Claire; Humphrey-Murto, Susan; Ainslie, Martha; Myers, Kathryn; Wood, Timothy J.

    2010-01-01

    Oral examinations have become more standardized over recent years. Traditionally a small number of raters were used for this type of examination. Past studies suggested that more raters should improve reliability. We compared the results of a multi-station structured oral examination using two different rater models, those based in a station,…

  5. Where Does Creativity Fit into a Productivist Industrial Model of Knowledge Production?

    ERIC Educational Resources Information Center

    Ghassib, Hisham B.

    2010-01-01

    The basic premise of this paper is the fact that science has become a major industry: the knowledge industry. The paper throws some light on the reasons for the transformation of science from a limited, constrained and marginal craft into a major industry. It, then, presents a productivist industrial model of knowledge production, which shows its…

  6. Collocational Processing in Light of the Phraseological Continuum Model: Does Semantic Transparency Matter?

    ERIC Educational Resources Information Center

    Gyllstad, Henrik; Wolter, Brent

    2016-01-01

    The present study investigates whether two types of word combinations (free combinations and collocations) differ in terms of processing by testing Howarth's Continuum Model based on word combination typologies from a phraseological tradition. A visual semantic judgment task was administered to advanced Swedish learners of English (n = 27) and…

  7. Access to a Responsiveness to Intervention Model: Does Beginning Intervention in Kindergarten Matter?

    ERIC Educational Resources Information Center

    O'Connor, Rollanda E.; Bocian, Kathleen M.; Sanchez, Victoria; Beach, Kristen D.

    2014-01-01

    In this study, we tested the outcomes of access to a response to intervention (RtI) model in kindergarten or in first grade on end-of-Grade-2 reading achievement and placement in special education. Across five schools, 214 students who began having access to Tier 2 intervention in kindergarten or first grade were compared in Grades 1 and 2 with…

  8. A Field-Based Deaf Education Teacher Training Model: Does It Make a Difference?

    ERIC Educational Resources Information Center

    Hadadian, Azar; Koch, Kourtland; Merbler, John

    2012-01-01

    This article provides professional perspective of a teacher-training model which relies heavily on an intensive, culturally immersive field experience for the teacher of the Deaf and hard of hearing. Survey results were based upon 21 past participants concerning their perceptions during their one-year internship experience at Indiana School for…

  9. A Simple Way of Modeling the Expansion of the Universe: What Does Light Tell Us?

    ERIC Educational Resources Information Center

    Coban, Gul Unal; Sengoren, Serap Kaya

    2011-01-01

    The purpose of this activity is to model the expansion of the universe by investigating the behavior of water waves. It is designed for students in the upper grades of physics and physical science who are learning about the wave nature of light and are ready to discover such important questions about science. The article explains first the Doppler…

  10. Encouraging Girls into Science and Technology with Feminine Role Model: Does This Work?

    ERIC Educational Resources Information Center

    Bamberger, Yael M.

    2014-01-01

    This study examines the effect of a program that aimed to encourage girls to choose a science, technology, engineering, and mathematics (STEM) career in Israel. The program involved school visits to a high-tech company and meeting with role model female scientists. Sixty ninth-grade female students from a Jewish modern-orthodox single-sex…

  11. Does a Socio-Ecological School Model Promote Resilience in Primary Schools?

    ERIC Educational Resources Information Center

    Lee, Patricia C.; Stewart, Donald E.

    2013-01-01

    Background: This research investigates the extent to which the holistic, multistrategy "health-promoting school" (HPS) model using a resilience intervention can lead to improved resilience among students. Methods: A quasi-experimental design using a study cohort selected from 20 primary schools in Queensland, Australia was employed. Ten…

  12. A Four- and Five-Factor Structural Model for Wechsler Tests: Does It Really Matter Clinically?

    ERIC Educational Resources Information Center

    Schwartz, David M.

    2013-01-01

    The purpose of this commentary is to focus on the clinical utility of the four- and five-factor structural models for the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) and Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). It provides a discussion of important considerations when evaluating the clinical utility of the…

  13. Does Mutual Interference Affect the Feeding Rate of Aphidophagous Coccinellids? A Modeling Perspective.

    PubMed

    Papanikolaou, Nikos E; Demiris, Nikos; Milonas, Panagiotis G; Preston, Simon; Kypraios, Theodore

    2016-01-01

    Mutual interference involves direct interactions between individuals of the same species that may alter their foraging success. Larvae of aphidophagous coccinellids typically stay within a patch during their lifetime, displaying remarkable aggregation to their prey. Thus, as larvae are exposed to each other, frequent encounters may affect their foraging success. A study was initiated in order to determine the effect of mutual interference in the coccinellids' feeding rate. One to four 4th larval instars of the fourteen-spotted ladybird beetle Propylea quatuordecimpunctata were exposed for 6 hours into plastic containers with different densities of the black bean aphid, Aphis fabae, on potted Vicia faba plants. The data were used to fit a purely prey-dependent Holling type II model and its alternatives which account for interference competition and have thus far been underutilized, i.e. the Beddington-DeAngelis, the Crowley-Martin and a modified Hassell-Varley model. The Crowley-Martin mechanistic model appeared to be slightly better among the competing models. The results showed that although the feeding rate became approximately independent of predator density at high prey density, some predator dependence in the coccinellid's functional response was observed at the low prey-high predator density combination. It appears that at low prey densities, digestion breaks are negligible so that the predators do waste time interfering with each other, whereas at high prey densities time loss during digestion breaks may fully accommodate the cost of interference, so that the time cost may be negligible. PMID:26756980

  14. Does Mutual Interference Affect the Feeding Rate of Aphidophagous Coccinellids? A Modeling Perspective.

    PubMed

    Papanikolaou, Nikos E; Demiris, Nikos; Milonas, Panagiotis G; Preston, Simon; Kypraios, Theodore

    2016-01-01

    Mutual interference involves direct interactions between individuals of the same species that may alter their foraging success. Larvae of aphidophagous coccinellids typically stay within a patch during their lifetime, displaying remarkable aggregation to their prey. Thus, as larvae are exposed to each other, frequent encounters may affect their foraging success. A study was initiated in order to determine the effect of mutual interference in the coccinellids' feeding rate. One to four 4th larval instars of the fourteen-spotted ladybird beetle Propylea quatuordecimpunctata were exposed for 6 hours into plastic containers with different densities of the black bean aphid, Aphis fabae, on potted Vicia faba plants. The data were used to fit a purely prey-dependent Holling type II model and its alternatives which account for interference competition and have thus far been underutilized, i.e. the Beddington-DeAngelis, the Crowley-Martin and a modified Hassell-Varley model. The Crowley-Martin mechanistic model appeared to be slightly better among the competing models. The results showed that although the feeding rate became approximately independent of predator density at high prey density, some predator dependence in the coccinellid's functional response was observed at the low prey-high predator density combination. It appears that at low prey densities, digestion breaks are negligible so that the predators do waste time interfering with each other, whereas at high prey densities time loss during digestion breaks may fully accommodate the cost of interference, so that the time cost may be negligible.

  15. How does temporal variability in model parameters affect the risk conclusions from MCnest?

    EPA Science Inventory

    USEPA recently began using the MCnest model for avian risk for adverse reproductive effects due to pesticide exposure. A more advanced version is currently under development and beta testing for use with threatened and endangered birds. For both versions, a species database has...

  16. What Does Data Tell Us about Decomposition Model of Soil Organic Matter?

    NASA Astrophysics Data System (ADS)

    Luo, Y.; Xu, X.; Todd-Brown, K. E.; Liang, J.

    2014-12-01

    Traditionally, soil carbon decomposition has been modeled by first-order, donor pool-dominated carbon transfers (i.e., linear model) as modified primarily by temperature and soil moisture. How the decomposition of soil organic matter (SOM) is regulated by various other biotic and abiotic processes, such as microbial community and activities, OM-mineral interactions, priming by input C, and SOM chemistry, has not been rigorously evaluated. As a consequence, those processes have not been well represented in Earth system models. In this presentation, we use three studies to illustrate how the data assimilation approach is used to examine influences of microbial functional genomics, soil properties, and priming on SOM decomposition. First, we optimally fitted a traditional three-pool (active, slow, and passive) C-cycling model with hundreds of data sets from soil incubation studies. Our results showed that decomposition rates of the active and the slow C pools significantly decrease with clay content, field water holding capacity, and C:N ratio. Multifactor regression and path analyses showed that clay content was the most important variable in regulating decomposition of SOC. Second, we used information from functional genomics study to constrain a soil C dynamic model. With an assumption that a specific community of microbes is associated with each substrate pool (i.e., quality), we linked the relative change in these microbes to the relative change in the substrate pool. Quantification of functional genes, combined with traditional CO2 flux and SOC measurements, substantially improves the transfer coefficient estimation in traditional decomposition models. Third, we estimated priming effects in a two-pool decomposition model from isotope data in soil incubation experiments. Our results showed that around half of the newly added labile carbon was stabilized into recalcitrant carbon in all the forest, grassland and cropland soils. As a result, despite that more old

  17. How much does weather-driven vegetation dynamics matter in land surface modelling?

    NASA Astrophysics Data System (ADS)

    Ingwersen, Joachim; Streck, Thilo

    2016-04-01

    Land surface models (LSM) are an essential part of weather and climate models as they provide the lower boundary condition for the atmospheric models. In state-of-the-art LSMs the seasonal vegetation dynamics is "frozen". The seasonal variation of vegetation state variables, such as leaf area index or green vegetation fraction, are prescribed in lookup tables. Hence, a year-by-year variation in the development of vegetation due to changing weather conditions cannot be considered. For climate simulations, this is obviously a severe drawback. The objective of the present study was to quantify the potential error in the simulation of land surface exchange processes resulting from "frozen" vegetation dynamics. For this purpose we simulated energy and water fluxes from a winter wheat stand and a maize stand in Southwest Germany. In a first set of simulations, six years (2010 to 2015) were simulated considering weather-driven vegetation dynamics. For this purpose, we coupled the generic crop growth model GECROS with the NOAH-MP model (NOAHMP-GECROS). In a second set of simulations all vegetation-related state variables of the 2010 simulation were written to an external file and were used to overwrite the vegetation-related state variables of the simulations of the years 2011-2015. The difference between both sets was taken as a measure for the potential error introduced to the LSM due to the assumption of a "frozen" vegetation dynamics. We will present first results and discuss the impact of "frozen" vegetation dynamics on climate change simulations.

  18. UCSD Geothermal Chemical Modeling Project: DOE Advanced Brine Chemistry Program. [University of California at San Diego (UCSD)

    SciTech Connect

    Moeller, N.; Weare, J.H.

    1992-04-01

    DOE funding to the UCSD Chemical Modeling Group supports research to provide computer models which will reliably characterize the equilibrium chemistry of geothermal brines (solution, solid and gas phases) under variable thermodynamic conditions. With this technology, it will be possible to rapidly and inexpensively predict the chemical behavior of geothermal brines during various resource recovery stages; exploration, production, plant energy extraction and rejection as well as in ancillary programs such as mineral recovery. Our modeling technology is based on recent progress in the physical chemistry of concentrated aqueous solutions. The behavior of these fluids has not been predicted from first principle theories. However, because of the importance of concentrated brines to many industrial and natural processes, there have been numerous efforts to develop accurate phenomenological expressions for predicting the chemical behavior of these brines. One of the most successful of these efforts is that of Pitzer and coworkers. Incorporating the semiempirical equations of Pitzer, we have shown at UCSD that we can create highly accurate models of brine-solid-gas chemistry.

  19. DOE/DHS INDUSTRIAL CONTROL SYSTEM CYBER SECURITY PROGRAMS: A MODEL FOR USE IN NUCLEAR FACILITY SAFEGUARDS AND SECURITY

    SciTech Connect

    Robert S. Anderson; Mark Schanfein; Trond Bjornard; Paul Moskowitz

    2011-07-01

    Many critical infrastructure sectors have been investigating cyber security issues for several years especially with the help of two primary government programs. The U.S. Department of Energy (DOE) National SCADA Test Bed and the U.S. Department of Homeland Security (DHS) Control Systems Security Program have both implemented activities aimed at securing the industrial control systems that operate the North American electric grid along with several other critical infrastructure sectors (ICS). These programs have spent the last seven years working with industry including asset owners, educational institutions, standards and regulating bodies, and control system vendors. The programs common mission is to provide outreach, identification of cyber vulnerabilities to ICS and mitigation strategies to enhance security postures. The success of these programs indicates that a similar approach can be successfully translated into other sectors including nuclear operations, safeguards, and security. The industry regulating bodies have included cyber security requirements and in some cases, have incorporated sets of standards with penalties for non-compliance such as the North American Electric Reliability Corporation Critical Infrastructure Protection standards. These DOE and DHS programs that address security improvements by both suppliers and end users provide an excellent model for nuclear facility personnel concerned with safeguards and security cyber vulnerabilities and countermeasures. It is not a stretch to imagine complete surreptitious collapse of protection against the removal of nuclear material or even initiation of a criticality event as witnessed at Three Mile Island or Chernobyl in a nuclear ICS inadequately protected against the cyber threat.

  20. The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis.

    PubMed

    Silva, Everton F; Medeiros, Marco A; McBride, Alan J A; Matsunaga, Jim; Esteves, Gabriela S; Ramos, João G R; Santos, Cleiton S; Croda, Júlio; Homma, Akira; Dellagostin, Odir A; Haake, David A; Reis, Mitermayer G; Ko, Albert I

    2007-08-14

    Subunit vaccines are a potential intervention strategy against leptospirosis, which is a major public health problem in developing countries and a veterinary disease in livestock and companion animals worldwide. Leptospiral immunoglobulin-like (Lig) proteins are a family of surface-exposed determinants that have Ig-like repeat domains found in virulence factors such as intimin and invasin. We expressed fragments of the repeat domain regions of LigA and LigB from Leptospira interrogans serovar Copenhageni. Immunization of Golden Syrian hamsters with Lig fragments in Freund's adjuvant induced robust antibody responses against recombinant protein and native protein, as detected by ELISA and immunoblot, respectively. A single fragment, LigANI, which corresponds to the six carboxy-terminal Ig-like repeat domains of the LigA molecule, conferred immunoprotection against mortality (67-100%, P<0.05) in hamsters which received a lethal inoculum of L. interrogans serovar Copenhageni. However, immunization with this fragment did not confer sterilizing immunity. These findings indicate that the carboxy-terminal portion of LigA is an immunoprotective domain and may serve as a vaccine candidate for human and veterinary leptospirosis. PMID:17629368

  1. To what extent does the salinity flux influence phytoplankton blooms? - Baltic Sea modeling study

    NASA Astrophysics Data System (ADS)

    Cieszyńska, Agata; Stramska, Małgorzata

    2016-04-01

    This work is focused on numerical modeling of biological-physical interactions and their influence on phytoplankton production and vertical distribution of biomass and its variability in the surface waters of the Baltic Sea. The area of interest is an inland sea with water salinity much smaller than observed in the global ocean (about one fifth of the open ocean value). Vertical distribution of the salinity has a significant influence on water column density stratification, and therefore influences intensity of mixing and the depth of mixed layer. This, in turn, defines environmental conditions for phytoplankton growth. Vertical distribution of water salinity in the basin is controlled by processes such as evaporation/precipitation, freezing/melting of sea ice and runoff of freshwater from land. There are a lot of different phytoplankton species in the area of the Baltic Sea. Every single one has its own characteristics and is sensitive to distinct complex environmental conditions. Biological-physical interactions controlling these microorganisms' life cycles are multiplicitous and because of their complexity difficult to quantify. The best and probably only way to study presented issue is the usage of numerical modeling tool. The results presented here are based on 1D numerical simulations carried out with Princeton Ocean Model (POM, http://www.ccpo.odu.edu/POMWEB/) merged with the Ecological Regional Ecosystem Model (ERGOM, http://ergom.net/) developed for the Baltic Sea research by German scientists from the Leibniz Institute for Baltic Sea Research in Warnemünde. In model simulations surface salinity flux was determined from the difference between the precipitation and evaporation rate at the air-sea interface. Data for parameterization of atmospheric forcing were defined based on data sets from National Centers of Environmental Prediction (NCEP). We carried out systematic calculations using different values of surface fluxes encompassing the range of

  2. Expression of cytokeratin confers multiple drug resistance.

    PubMed Central

    Bauman, P A; Dalton, W S; Anderson, J M; Cress, A E

    1994-01-01

    The cytokeratin network is an extensive filamentous structure in the cytoplasm whose biological function(s) is unknown. Based upon previous data showing the modification of cytokeratin by mitoxantrone, we investigated the ability of cytokeratin networks to influence the survival response of cells to chemotherapeutic agents. We have compared the survival of mouse L fibroblasts lacking cytokeratins with that of L cells transfected with cytokeratins 8 and 18 in the presence of chemotherapeutic drugs. The expression of cytokeratins 8 and 18 conferred a multiple drug resistance phenotype on cells exposed to mitoxantrone, doxorubicin, methotrexate, melphalan, Colcemid, and vincristine. The degree of drug resistance was 5-454 times that of parental cells, depending upon the agent used. Drug resistance could not be attributed to altered growth characteristics, altered drug accumulation, or an altered drug efflux in the transfected cells. Cytokeratin does not confer resistance to ionizing radiation, which damages DNA independently of intracellular transport mechanisms. These data suggest a role for cytokeratin networks in conferring a drug resistance phenotype. Images PMID:7515497

  3. Ultraviolet A does not induce melanomas in a Xiphophorus hybrid fish model

    PubMed Central

    Mitchell, David L.; Fernandez, André A.; Nairn, Rodney S.; Garcia, Rachel; Paniker, Lakshmi; Trono, David; Thames, Howard D.; Gimenez-Conti, Irma

    2010-01-01

    We examined the wavelength dependence of ultraviolet (UV) ra-diation (UVR)-induced melanoma in a Xiphophorus backcross hybrid model previously reported to be susceptible to melanoma induction by ultraviolet A (UVA) and visible light. Whereas ultraviolet B (UVB) irradiation of neonates yielded high frequencies of melanomas in pigmented fish, UVA irradiation resulted in melanoma frequencies that were not significantly different from unirradiated fish. Spontaneous and UV-induced melanoma frequencies correlated with the degree of pigmentation as expected from previous studies, and the histopathology phenotypes of the melanomas were not found in significantly different proportions in UV-treated and -untreated tumor-bearing fish. Our results support the conclusion that a brief early-life exposure to UVB radiation causes melanoma formation in this animal model. These data are consistent with an essential role for direct DNA damage, including cyclobutane dimers and (6-4) photoproducts, in the etiology of melanoma. PMID:20439744

  4. Ultraviolet A does not induce melanomas in a Xiphophorus hybrid fish model.

    PubMed

    Mitchell, David L; Fernandez, André A; Nairn, Rodney S; Garcia, Rachel; Paniker, Lakshmi; Trono, David; Thames, Howard D; Gimenez-Conti, Irma

    2010-05-18

    We examined the wavelength dependence of ultraviolet (UV) ra-diation (UVR)-induced melanoma in a Xiphophorus backcross hybrid model previously reported to be susceptible to melanoma induction by ultraviolet A (UVA) and visible light. Whereas ultraviolet B (UVB) irradiation of neonates yielded high frequencies of melanomas in pigmented fish, UVA irradiation resulted in melanoma frequencies that were not significantly different from unirradiated fish. Spontaneous and UV-induced melanoma frequencies correlated with the degree of pigmentation as expected from previous studies, and the histopathology phenotypes of the melanomas were not found in significantly different proportions in UV-treated and -untreated tumor-bearing fish. Our results support the conclusion that a brief early-life exposure to UVB radiation causes melanoma formation in this animal model. These data are consistent with an essential role for direct DNA damage, including cyclobutane dimers and (6-4) photoproducts, in the etiology of melanoma.

  5. Why does a ball fall?: A new visualization for Einstein's model of gravity

    NASA Astrophysics Data System (ADS)

    Gould, Roy R.

    2016-05-01

    Many physics teachers seek a simple illustration of Einstein's model of gravity, suitable for the introductory physics classroom. In this article, we show that an ordinary wall map of the world can be used to contrast Newton's and Einstein's explanations for why a ball falls when released. Trajectories on the map are analogous to the trajectories of the ball through spacetime, because the geometry of the map is remarkably similar to the geometry of spacetime near Earth's surface. To aid in the pedagogy, we focus on the concept of scale rather than curvature. We show that, contrary to popular visualizations of Einstein's model, it is primarily the warping of time, not space, that causes a ball to fall, and we address the question of why we do not see the distortion of spacetime around us. Finally, we recover Newton's results for the falling ball from our geometrical treatment.

  6. Why does placing the question before an arithmetic word problem improve performance? A situation model account.

    PubMed

    Thevenot, Catherine; Devidal, Michel; Barrouillet, Pierre; Fayol, Michel

    2007-01-01

    The aim of this paper is to investigate the controversial issue of the nature of the representation constructed by individuals to solve arithmetic word problems. More precisely, we consider the relevance of two different theories: the situation or mental model theory (Johnson-Laird, 1983; Reusser, 1989) and the schema theory (Kintsch & Greeno, 1985; Riley, Greeno, & Heller, 1983). Fourth-graders who differed in their mathematical skills were presented with problems that varied in difficulty and with the question either before or after the text. We obtained the classic effect of the position of the question, with better performance when the question was presented prior to the text. In addition, this effect was more marked in the case of children who had poorer mathematical skills and in the case of more difficult problems. We argue that this pattern of results is compatible only with the situation or mental model theory, and not with the schema theory. PMID:17162507

  7. How does treatment satisfaction work?: Modeling determinants of treatment satisfaction and preference.

    PubMed

    Peyrot, Mark; Rubin, Richard R

    2009-08-01

    OBJECTIVE This study tested a model hypothesizing that treatment affects objective clinical outcomes, which in turn affect perceived consequences, which in turn affect satisfaction and preference judgments. RESEARCH DESIGN AND METHODS The model was tested in a double-blind, randomized clinical trial in which 266 patients with type 1 diabetes added active or placebo pramlintide to their insulin regimens. Objective clinical outcomes included changes in glucose and weight control, insulin requirements, incidence of hypoglycemia, and study drug tolerance. At the end of the trial, patients completed the validated PRAM-TSQ questionnaire measuring treatment satisfaction and preference and perceived medication benefits and side effects. RESULTS Statistical modeling demonstrated that active pramlintide was significantly associated with greater treatment satisfaction, preference, and perceived benefits (all except hypoglycemia prevention), as well as objective clinical outcomes (weight loss, lower postprandial glucose [PPG], lower medication tolerance, more hypoglycemia). Perceptions of treatment consequences were sensitive and specific to their cognate objective clinical outcomes (no halo effects). Clinical outcomes (especially PPG) accounted for almost half of the effect of the study medication on treatment satisfaction and preference. Treatment satisfaction and preference were strongly related to the perceived benefits/side effects of the study medication, and these perceptions (especially glucose control) mediated most of the association of clinical outcomes with satisfaction and preference. CONCLUSIONS This model received substantial empirical support. Improvements in objective clinical outcomes accounted for a large part of the association of pramlintide treatment with higher treatment satisfaction and preference. Perceived treatment consequences mediated the effect of objective clinical benefits on satisfaction with and preference for the study medication.

  8. Does Mutual Interference Affect the Feeding Rate of Aphidophagous Coccinellids? A Modeling Perspective

    PubMed Central

    Papanikolaou, Nikos E.; Demiris, Nikos; Milonas, Panagiotis G.; Preston, Simon; Kypraios, Theodore

    2016-01-01

    Mutual interference involves direct interactions between individuals of the same species that may alter their foraging success. Larvae of aphidophagous coccinellids typically stay within a patch during their lifetime, displaying remarkable aggregation to their prey. Thus, as larvae are exposed to each other, frequent encounters may affect their foraging success. A study was initiated in order to determine the effect of mutual interference in the coccinellids’ feeding rate. One to four 4th larval instars of the fourteen-spotted ladybird beetle Propylea quatuordecimpunctata were exposed for 6 hours into plastic containers with different densities of the black bean aphid, Aphis fabae, on potted Vicia faba plants. The data were used to fit a purely prey-dependent Holling type II model and its alternatives which account for interference competition and have thus far been underutilized, i.e. the Beddington-DeAngelis, the Crowley-Martin and a modified Hassell-Varley model. The Crowley-Martin mechanistic model appeared to be slightly better among the competing models. The results showed that although the feeding rate became approximately independent of predator density at high prey density, some predator dependence in the coccinellid’s functional response was observed at the low prey—high predator density combination. It appears that at low prey densities, digestion breaks are negligible so that the predators do waste time interfering with each other, whereas at high prey densities time loss during digestion breaks may fully accommodate the cost of interference, so that the time cost may be negligible. PMID:26756980

  9. Modeling terrestrial carbon and water dynamics across climatic gradients: does plant trait diversity matter?

    PubMed

    Pappas, Christoforos; Fatichi, Simone; Burlando, Paolo

    2016-01-01

    Plant trait diversity in many vegetation models is crudely represented using a discrete classification of a handful of 'plant types' (named plant functional types; PFTs). The parameterization of PFTs reflects mean properties of observed plant traits over broad categories ignoring most of the inter- and intraspecific plant trait variability. Taking advantage of a multivariate leaf-trait distribution (leaf economics spectrum), as well as documented plant drought strategies, we generate an ensemble of hypothetical species with coordinated attributes, rather than using few PFTs. The behavior of these proxy species is tested using a mechanistic ecohydrological model that translates plant traits into plant performance. Simulations are carried out for a range of climates representative of different elevations and wetness conditions in the European Alps. Using this framework we investigate the sensitivity of ecosystem response to plant trait diversity and compare it with the sensitivity to climate variability. Plant trait diversity leads to highly divergent vegetation carbon dynamics (fluxes and pools) and to a lesser extent water fluxes (transpiration). Abiotic variables, such as soil water content and evaporation, are only marginally affected. These results highlight the need for revising the representation of plant attributes in vegetation models. Probabilistic approaches, based on observed multivariate whole-plant trait distributions, provide a viable alternative.

  10. How does pollination mutualism affect the evolution of prior self-fertilization? A model.

    PubMed

    Lepers, Clotilde; Dufay, Mathilde; Billiard, Sylvain

    2014-12-01

    The mode of pollination is often neglected regarding the evolution of selfing. Yet the distribution of mating systems seems to depend on the mode of pollination, and pollinators are likely to interfere with selfing evolution, since they can cause strong selective pressures on floral traits. Most selfing species reduce their investment in reproduction, and display smaller flowers, with less nectar and scents (referred to as selfing syndrome). We model the evolution of prior selfing when it affects both the demography of plants and pollinators and the investment of plants in pollination. Including the selfing syndrome in the model allows to predict several outcomes: plants can evolve either toward complete outcrossing, complete selfing, or to a stable mixed-mating system, even when inbreeding depression is high. We predict that the evolution to high prior selfing could lead to evolutionary suicides, highlighting the importance of merging demography and evolution in models. The consequence of the selfing syndrome on plant-pollinator interactions could be a widespread mechanism driving the evolution of selfing in animal-pollinated taxa.

  11. Does really Born Oppenheimer approximation break down in charge transfer processes? An exactly solvable model

    NASA Astrophysics Data System (ADS)

    Kuznetsov, Alexander M.; Medvedev, Igor G.

    2006-05-01

    Effects of deviation from the Born-Oppenheimer approximation (BOA) on the non-adiabatic transition probability for the transfer of a quantum particle in condensed media are studied within an exactly solvable model. The particle and the medium are modeled by a set of harmonic oscillators. The dynamic interaction of the particle with a single local mode is treated explicitly without the use of BOA. Two particular situations (symmetric and non-symmetric systems) are considered. It is shown that the difference between the exact solution and the true BOA is negligibly small at realistic parameters of the model. However, the exact results differ considerably from those of the crude Condon approximation (CCA) which is usually considered in the literature as a reference point for BOA (Marcus-Hush-Dogonadze formula). It is shown that the exact rate constant can be smaller (symmetric system) or larger (non-symmetric one) than that obtained in CCA. The non-Condon effects are also studied.

  12. Modeling terrestrial carbon and water dynamics across climatic gradients: does plant trait diversity matter?

    PubMed

    Pappas, Christoforos; Fatichi, Simone; Burlando, Paolo

    2016-01-01

    Plant trait diversity in many vegetation models is crudely represented using a discrete classification of a handful of 'plant types' (named plant functional types; PFTs). The parameterization of PFTs reflects mean properties of observed plant traits over broad categories ignoring most of the inter- and intraspecific plant trait variability. Taking advantage of a multivariate leaf-trait distribution (leaf economics spectrum), as well as documented plant drought strategies, we generate an ensemble of hypothetical species with coordinated attributes, rather than using few PFTs. The behavior of these proxy species is tested using a mechanistic ecohydrological model that translates plant traits into plant performance. Simulations are carried out for a range of climates representative of different elevations and wetness conditions in the European Alps. Using this framework we investigate the sensitivity of ecosystem response to plant trait diversity and compare it with the sensitivity to climate variability. Plant trait diversity leads to highly divergent vegetation carbon dynamics (fluxes and pools) and to a lesser extent water fluxes (transpiration). Abiotic variables, such as soil water content and evaporation, are only marginally affected. These results highlight the need for revising the representation of plant attributes in vegetation models. Probabilistic approaches, based on observed multivariate whole-plant trait distributions, provide a viable alternative. PMID:26389742

  13. Advanced Pellet-Cladding Interaction Modeling using the US DOE CASL Fuel Performance Code: Peregrine

    SciTech Connect

    Montgomery, Robert O.; Capps, Nathan A.; Sunderland, Dion J.; Liu, Wenfeng; Hales, Jason; Stanek, Chris; Wirth, Brian D.

    2014-06-15

    The US DOE’s Consortium for Advanced Simulation of LWRs (CASL) program has undertaken an effort to enhance and develop modeling and simulation tools for a virtual reactor application, including high fidelity neutronics, fluid flow/thermal hydraulics, and fuel and material behavior. The fuel performance analysis efforts aim to provide 3-dimensional capabilities for single and multiple rods to assess safety margins and the impact of plant operation and fuel rod design on the fuel thermo-mechanical-chemical behavior, including Pellet-Cladding Interaction (PCI) failures and CRUD-Induced Localized Corrosion (CILC) failures in PWRs. [1-3] The CASL fuel performance code, Peregrine, is an engineering scale code that is built upon the MOOSE/ELK/FOX computational FEM framework, which is also common to the fuel modeling framework, BISON [4,5]. Peregrine uses both 2-D and 3-D geometric fuel rod representations and contains a materials properties and fuel behavior model library for the UO2 and Zircaloy system common to PWR fuel derived from both open literature sources and the FALCON code [6]. The primary purpose of Peregrine is to accurately calculate the thermal, mechanical, and chemical processes active throughout a single fuel rod during operation in a reactor, for both steady state and off-normal conditions.

  14. Advanced Pellet Cladding Interaction Modeling Using the US DOE CASL Fuel Performance Code: Peregrine

    SciTech Connect

    Jason Hales; Various

    2014-06-01

    The US DOE’s Consortium for Advanced Simulation of LWRs (CASL) program has undertaken an effort to enhance and develop modeling and simulation tools for a virtual reactor application, including high fidelity neutronics, fluid flow/thermal hydraulics, and fuel and material behavior. The fuel performance analysis efforts aim to provide 3-dimensional capabilities for single and multiple rods to assess safety margins and the impact of plant operation and fuel rod design on the fuel thermomechanical- chemical behavior, including Pellet-Cladding Interaction (PCI) failures and CRUD-Induced Localized Corrosion (CILC) failures in PWRs. [1-3] The CASL fuel performance code, Peregrine, is an engineering scale code that is built upon the MOOSE/ELK/FOX computational FEM framework, which is also common to the fuel modeling framework, BISON [4,5]. Peregrine uses both 2-D and 3-D geometric fuel rod representations and contains a materials properties and fuel behavior model library for the UO2 and Zircaloy system common to PWR fuel derived from both open literature sources and the FALCON code [6]. The primary purpose of Peregrine is to accurately calculate the thermal, mechanical, and chemical processes active throughout a single fuel rod during operation in a reactor, for both steady state and off-normal conditions.

  15. A latent growth model suggests that empathy of medical students does not decline over time.

    PubMed

    Costa, Patrício; Magalhães, Eunice; Costa, Manuel João

    2013-08-01

    Empathy is a relevant attribute in the context of patient care. However, a decline in empathy throughout medical education has been reported in North-American medical schools, particularly, in the transition to clinical training. The present study aims to longitudinally model empathy during medical school at three time points: at the entrance, final of pre-clinical phase and at the beginning of clinical training. Data collected with the adaptation to Portuguese of the Jefferson Scale of Physician Empathy (student version) were analysed with latent growth modelling, conditioned by gender, openness and agreeableness. Empathy scores at all times were higher for females than for males, but only significantly at the end of the preclinical phase. The model showed a satisfactory fit level and the primary finding was that undergraduate medical student's empathy did not decline over time. Empathy scores were significantly and positively related with Openness to Experience and Agreeableness at admission, but the empathy rate of change across time was not significant. The stability of empathy revealed by a longitudinal methodology applied for the first time to empathy studying, contradicts previous results of decline and contributes to the understanding of the empathy development of medical students.

  16. Does Litter Size Variation Affect Models of Terrestrial Carnivore Extinction Risk and Management?

    PubMed Central

    Devenish-Nelson, Eleanor S.; Stephens, Philip A.; Harris, Stephen; Soulsbury, Carl; Richards, Shane A.

    2013-01-01

    Background Individual variation in both survival and reproduction has the potential to influence extinction risk. Especially for rare or threatened species, reliable population models should adequately incorporate demographic uncertainty. Here, we focus on an important form of demographic stochasticity: variation in litter sizes. We use terrestrial carnivores as an example taxon, as they are frequently threatened or of economic importance. Since data on intraspecific litter size variation are often sparse, it is unclear what probability distribution should be used to describe the pattern of litter size variation for multiparous carnivores. Methodology/Principal Findings We used litter size data on 32 terrestrial carnivore species to test the fit of 12 probability distributions. The influence of these distributions on quasi-extinction probabilities and the probability of successful disease control was then examined for three canid species – the island fox Urocyon littoralis, the red fox Vulpes vulpes, and the African wild dog Lycaon pictus. Best fitting probability distributions differed among the carnivores examined. However, the discretised normal distribution provided the best fit for the majority of species, because variation among litter-sizes was often small. Importantly, however, the outcomes of demographic models were generally robust to the distribution used. Conclusion/Significance These results provide reassurance for those using demographic modelling for the management of less studied carnivores in which litter size variation is estimated using data from species with similar reproductive attributes. PMID:23469140

  17. Calix 2007:9th International Conference on Calixarene Chemistry

    SciTech Connect

    Jeffery Davis

    2011-09-09

    The DOE funds helped support an International Conference, Calix 2007, whose focus was on Supramolecular Chemistry. The conference was held at the University of Maryland from August 6-9, 2007 (Figure 1). The conference website is at www.chem.umd.edu/Conferences/Calix2007. This biannual conference had previously been held in the Czech Republic (2005), Canada (2003), Netherlands (2001), Australia (1999), Italy (1997), USA (Fort Worth, 1995) Japan (1993) and Germany (1991). Calixarenes are cup-shaped compounds that are a major part of Supramolecular Chemistry, for which Cram, Lehn and Pederson were awarded a Nobel Prize 20 years ago. Calixarene chemistry has expanded greatly in the last 2 decades, as these compounds are used in synthetic and mechanistic chemistry, separations science, materials science, nanoscience and biological chemistry. The organizing committee was quite happy that Calix 2007 encompassed the broad scope and interdisciplinary nature of the field. Our goal was to bring together leading scientists interested in calixarenes, molecular recognition, nanoscience and supramolecular chemistry. We believe that new research directions and collaborations resulted from an exchange of ideas between conferees. This grant from the DOE was crucial toward achieving that goal, as the funds helped cover some of the registration and accommodations costs for the speakers.

  18. Does Diversity Matter In Modeling? Testing A New Version Of The FORMIX3 Growth Model For Madagascar Rainforests

    NASA Astrophysics Data System (ADS)

    Armstrong, A. H.; Fischer, R.; Shugart, H. H.; Huth, A.

    2012-12-01

    Ecological forecasting has become an essential tool used by ecologists to understand the dynamics of growth and disturbance response in threatened ecosystems such as the rainforests of Madagascar. In the species rich tropics, forest conservation is often eclipsed by anthropogenic factors, resulting in a heightened need for accurate assessment of biomass before these ecosystems disappear. The objective of this study was to test a new Madagascar rainforest specific version of the FORMIX3 growth model (Huth and Ditzer, 2000; Huth et al 1998) to assess how accurately biomass can be simulated in high biodiversity forests using a method of functional type aggregation in an individual-based model framework. Rainforest survey data collected over three growing seasons, including 265 tree species, was aggregated into 12 plant functional types based on size and light requirements. Findings indicated that the forest study site compared best when the simulated forest reached mature successional status. Multiple level comparisons between model simulation data and survey plot data found that though some features, such as the dominance of canopy emergent species and relative absence of small woody treelets are captured by the model, other forest attributes were not well reflected. Overall, the ability to accurately simulate the Madagascar rainforest was slightly diminished by the aggregation of tree species into size and light requirement functional type groupings.

  19. Does mechanistic modeling of filter strip pesticide mass balance and degradation processes affect environmental exposure assessments?

    PubMed

    Muñoz-Carpena, Rafael; Ritter, Amy; Fox, Garey A; Perez-Ovilla, Oscar

    2015-11-01

    Vegetative filter strips (VFS) are a widely adopted practice for limiting pesticide transport from adjacent fields to receiving waterbodies. The efficacy of VFS depends on site-specific input factors. To elucidate the complex and non-linear relationships among these factors requires a process-based modeling framework. Previous research proposed linking existing higher-tier environmental exposure models with a well-tested VFS model (VFSMOD). However, the framework assumed pesticide mass stored in the VFS was not available for transport in subsequent storm events. A new pesticide mass balance component was developed to estimate surface pesticide residue trapped in the VFS and its degradation between consecutive runoff events. The influence and necessity of the updated framework on acute and chronic estimated environmental concentrations (EECs) and percent reductions in EECs were investigated across three, 30-year U.S. EPA scenarios: Illinois corn, California tomato, and Oregon wheat. The updated framework with degradation predicted higher EECs than the existing framework without degradation for scenarios with greater sediment transport, longer VFS lengths, and highly sorbing and persistent pesticides. Global sensitivity analysis (GSA) assessed the relative importance of mass balance and degradation processes in the context of other input factors like VFS length (VL), organic-carbon sorption coefficient (Koc), and soil and water half-lives. Considering VFS pesticide residue and degradation was not important if single, large runoff events controlled transport, as is typical for higher percentiles considered in exposure assessments. Degradation processes become more important when considering percent reductions in acute or chronic EECs, especially under scenarios with lower pesticide losses.

  20. Modelling the effect of agricultural management practices on soil organic carbon stocks: does soil erosion matter?

    NASA Astrophysics Data System (ADS)

    Nadeu, Elisabet; Van Wesemael, Bas; Van Oost, Kristof

    2014-05-01

    Over the last decades, an increasing number of studies have been conducted to assess the effect of soil management practices on soil organic carbon (SOC) stocks. At regional scales, biogeochemical models such as CENTURY or Roth-C have been commonly applied. These models simulate SOC dynamics at the profile level (point basis) over long temporal scales but do not consider the continuous lateral transfer of sediment that takes place along geomorphic toposequences. As a consequence, the impact of soil redistribution on carbon fluxes is very seldom taken into account when evaluating changes in SOC stocks due to agricultural management practices on the short and long-term. To address this gap, we assessed the role of soil erosion by water and tillage on SOC stocks under different agricultural management practices in the Walloon region of Belgium. The SPEROS-C model was run for a 100-year period combining three typical crop rotations (using winter wheat, winter barley, sugar beet and maize) with three tillage scenarios (conventional tillage, reduced tillage and reduced tillage in combination with additional crop residues). The results showed that including soil erosion by water in the simulations led to a general decrease in SOC stocks relative to a baseline scenario (where no erosion took place). The SOC lost from these arable soils was mainly exported to adjacent sites and to the river system by lateral fluxes, with magnitudes differing between crop rotations and in all cases lower under conservation tillage practices than under conventional tillage. Although tillage erosion plays an important role in carbon redistribution within fields, lateral fluxes induced by water erosion led to a higher spatial and in-depth heterogeneity of SOC stocks with potential effects on the soil water holding capacity and crop yields. This indicates that studies assessing the effect of agricultural management practices on SOC stocks and other soil properties over the landscape should

  1. Does mechanistic modeling of filter strip pesticide mass balance and degradation processes affect environmental exposure assessments?

    PubMed

    Muñoz-Carpena, Rafael; Ritter, Amy; Fox, Garey A; Perez-Ovilla, Oscar

    2015-11-01

    Vegetative filter strips (VFS) are a widely adopted practice for limiting pesticide transport from adjacent fields to receiving waterbodies. The efficacy of VFS depends on site-specific input factors. To elucidate the complex and non-linear relationships among these factors requires a process-based modeling framework. Previous research proposed linking existing higher-tier environmental exposure models with a well-tested VFS model (VFSMOD). However, the framework assumed pesticide mass stored in the VFS was not available for transport in subsequent storm events. A new pesticide mass balance component was developed to estimate surface pesticide residue trapped in the VFS and its degradation between consecutive runoff events. The influence and necessity of the updated framework on acute and chronic estimated environmental concentrations (EECs) and percent reductions in EECs were investigated across three, 30-year U.S. EPA scenarios: Illinois corn, California tomato, and Oregon wheat. The updated framework with degradation predicted higher EECs than the existing framework without degradation for scenarios with greater sediment transport, longer VFS lengths, and highly sorbing and persistent pesticides. Global sensitivity analysis (GSA) assessed the relative importance of mass balance and degradation processes in the context of other input factors like VFS length (VL), organic-carbon sorption coefficient (Koc), and soil and water half-lives. Considering VFS pesticide residue and degradation was not important if single, large runoff events controlled transport, as is typical for higher percentiles considered in exposure assessments. Degradation processes become more important when considering percent reductions in acute or chronic EECs, especially under scenarios with lower pesticide losses. PMID:26218348

  2. Rural Energy Conference Project

    SciTech Connect

    Dennis Witmer; Shannon Watson

    2008-12-31

    Alaska remains, even at the beginning of the 21st century, a place with many widely scattered, small, remote communities, well beyond the end of both the road system and the power grid. These communities have the highest energy costs of any place in the United States, despite the best efforts of the utilities that service them. This is due to the widespread dependence on diesel electric generators, which require small capital investments, but recent increases in crude oil prices have resulted in dramatic increases in the cost of power. In the enabling legislation for the Arctic Energy Office in 2001, specific inclusion was made for the study of ways of reducing the cost of electrical power in these remote communities. As part of this mandate, the University of Alaska has, in conjunction with the US Department of Energy, the Denali Commission and the Alaska Energy Authority, organized a series of rural energy conferences, held approximately every 18 months. The goal of these meeting was to bring together rural utility operators, rural community leaders, government agency representatives, equipment suppliers, and researchers from universities and national laboratories to discuss the current state of the art in rural power generation, to discuss current projects, including successes as well as near successes. Many of the conference presenters were from industry and not accustomed to writing technical papers, so the typical method of organizing a conference by requesting abstracts and publishing proceedings was not considered viable. Instead, the organizing committee solicited presentations from appropriate individuals, and requested that (if they were comfortable with computers) prepare Power point presentations that were collected and posted on the web. This has become a repository of many presentations, and may be the best single source of information about current projects in the state of Alaska.

  3. How well does end-member modelling analysis of grain size data work?

    NASA Astrophysics Data System (ADS)

    Schulte, Philipp; Dietze, Michael; Dietze, Elisabeth

    2014-05-01

    End-member modelling analysis (EMMA) is a powerful and flexible statistic approach to identify and quantify generic sediment transport processes from multimodal grain-size distributions. EMMA has been introduced over 15 years ago and is now available in different approaches as encapsulated FORTRAN code (Weltje, 1997), Matlab-script (Dietze et al., 2012) and the R-package EMMAgeo (Dietze and Dietze, 2013). EMMA was mainly used to reconstruct past sedimentation processes in a variety of sedimentary environments (marine, aeolian, lacustrine). Typically, it is rather difficult to assess how meaningful and well the model performs in a certain environment, since neither the actual process end-members (generic grain-size distributions sorted by a certain sediment transport) nor their individual contributions to each sample are known a priori. To allow a comprehensive performance test, we sampled a set of four known process end-members: alluvial sand (main mode: 0.70±0.55 φ), dune sand (main mode: 1.35±0.60 φ), loess (main mode: 4.71±0.65 φ) and overbank deposit (main mode: 5.81±1.62 φ). High resolution grain-size information is based on laser-diffraction analysis (116 classes). The four process end-members were artificially mixed with random, but known proportions to yield 100 samples. This mixed data set was measured again with the laser particle size analyser and served as input for EMMA within the R-package EMMAgeo. This contribution discusses the ability of EMMA to identify and characterise the four distinct process end-members and quantify their contributions to each sample. Different ways to estimate uncertainties are presented. Further evaluations focus on the influence of numbers of included samples, numbers of grain-size classes, vertical mixing of samples (simulating turbation) and self-similarity of process end-members. Dietze E, et al. 2012. An end-member algorithm for deciphering modern detrital processes from lake sediments of Lake Donggi Cona, NE

  4. What does it mean to manage sky survey data? A model to facilitate stakeholder conversations

    NASA Astrophysics Data System (ADS)

    Sands, Ashley E.; Darch, Peter T.

    2016-06-01

    Astronomy sky surveys, while of great scientific value independently, can be deployed even more effectively when multiple sources of data are combined. Integrating discrete datasets is a non-trivial exercise despite investments in standard data formats and tools. Creating and maintaining data and associated infrastructures requires investments in technology and expertise. Combining data from multiple sources necessitates a common understanding of data, structures, and goals amongst relevant stakeholders.We present a model of Astronomy Stakeholder Perspectives on Data. The model is based on 80 semi-structured interviews with astronomers, computational astronomers, computer scientists, and others involved in the building or use of the Sloan Digital Sky Survey (SDSS) and Large Synoptic Survey Telescope (LSST). Interviewees were selected to ensure a range of roles, institutional affiliations, career stages, and level of astronomy education. Interviewee explanations of data were analyzed to understand how perspectives on astronomy data varied by stakeholder.Interviewees described sky survey data either intrinsically or extrinsically. “Intrinsic” descriptions of data refer to data as an object in and of itself. Respondents with intrinsic perspectives view data management in one of three ways: (1) “Medium” - securing the zeros and ones from bit rot; (2) “Scale” - assuring that changes in state are documented; or (3) “Content” - ensuring the scientific validity of the images, spectra, and catalogs.“Extrinsic” definitions, in contrast, define data in relation to other forms of information. Respondents with extrinsic perspectives view data management in one of three ways: (1) “Source” - supporting the integrity of the instruments and documentation; (2) “Relationship” - retaining relationships between data and their analytical byproducts; or (3) “Use” - ensuring that data remain scientifically usable.This model shows how data management can

  5. Understanding Building Infrastructure and Building Operation through DOE Asset Score Model: Lessons Learned from a Pilot Project

    SciTech Connect

    Wang, Na; Goel, Supriya; Gorrissen, Willy J.; Makhmalbaf, Atefe

    2013-06-24

    The U.S. Department of Energy (DOE) is developing a national voluntary energy asset score system to help building owners to evaluate the as-built physical characteristics (including building envelope, the mechanical and electrical systems) and overall building energy efficiency, independent of occupancy and operational choices. The energy asset score breaks down building energy use information by simulating building performance under typical operating and occupancy conditions for a given use type. A web-based modeling tool, the energy asset score tool facilitates the implementation of the asset score system. The tool consists of a simplified user interface built on a centralized simulation engine (EnergyPlus). It is intended to reduce both the implementation cost for the users and increase modeling standardization compared with an approach that requires users to build their own energy models. A pilot project with forty-two buildings (consisting mostly offices and schools) was conducted in 2012. This paper reports the findings. Participants were asked to collect a minimum set of building data and enter it into the asset score tool. Participants also provided their utility bills, existing ENERGY STAR scores, and previous energy audit/modeling results if available. The results from the asset score tool were compared with the building energy use data provided by the pilot participants. Three comparisons were performed. First, the actual building energy use, either from the utility bills or via ENERGY STAR Portfolio Manager, was compared with the modeled energy use. It was intended to examine how well the energy asset score represents a building’s system efficiencies, and how well it is correlated to a building’s actual energy consumption. Second, calibrated building energy models (where they exist) were used to examine any discrepancies between the asset score model and the pilot participant buildings’ [known] energy use pattern. This comparison examined the end

  6. Aerospace Environmental Technology Conference

    NASA Technical Reports Server (NTRS)

    Whitaker, A. F. (Editor)

    1995-01-01

    The mandated elimination of CFC's, Halons, TCA, and other ozone depleting chemicals and specific hazardous materials has required changes and new developments in aerospace materials and processes. The aerospace industry has been involved for several years in providing product substitutions, redesigning entire production processes, and developing new materials that minimize or eliminate damage to the environment. These activities emphasize replacement cleaning solvents and their application verifications, compliant coatings including corrosion protection systems, and removal techniques, chemical propulsion effects on the environment, and the initiation of modifications to relevant processing and manufacturing specifications and standards. The Executive Summary of this Conference is published as NASA CP-3297.

  7. Does the Village model help to foster age-friendly communities?

    PubMed

    Scharlach, Andrew E; Davitt, Joan K; Lehning, Amanda J; Greenfield, Emily A; Graham, Carrie L

    2014-01-01

    This article explores the potential role of the Village model, a social initiative that emphasizes member involvement and service access, in helping communities to become more age-friendly. A survey of 86.3% of operational Villages examined activities designed to help members access a variety of supports and services consistent with the World Health Organization's (WHO) Global Network of Age-Friendly Cities and Communities program model, as well as other potential contributions to community age friendliness. Analysis revealed that 85.5% of Villages provided assistance with at least six of the eight WHO domains, but only 10.1% implemented features of all eight; more than one-third were engaged in direct or indirect efforts to improve community physical or social infrastructures or improve community attitudes toward older persons. These findings suggest that Villages and other social organizations may have untapped potential for enhancing their members' ability to age in place consistent with the goals of age-friendly initiatives while also promoting constructive changes in the overall community. PMID:24224776

  8. Arabidopsis thaliana as a model species for xylem hydraulics: does size matter?

    PubMed

    Tixier, Aude; Cochard, Hervé; Badel, Eric; Dusotoit-Coucaud, Anaïs; Jansen, Steven; Herbette, Stéphane

    2013-05-01

    While Arabidopsis thaliana has been proposed as a model species for wood development, the potential of this tiny herb for studying xylem hydraulics remains unexplored and anticipated by scepticism. Inflorescence stems of A. thaliana were used to measure hydraulic conductivity and cavitation resistance, whereas light and electron microscopy allowed observations of vessels. In wild-type plants, measured and theoretical conductivity showed a significant correlation (R (2) = 0.80, P < 0.01). Moreover, scaling of vessel dimensions and intervessel pit structure of A. thaliana were consistent with structure-function relationships of woody plants. The reliability and resolution of the hydraulic methods applied to measure vulnerability to cavitation were addressed by comparing plants grown under different photoperiods or different mutant lines. Sigmoid vulnerability curves of A. thaliana indicated a pressure corresponding to 50% loss of hydraulic conductance (P 50) between -3 and -2.5MPa for short-day and long-day plants, respectively. Polygalacturonase mutants showed a higher P 50 value (-2.25MPa), suggesting a role for pectins in vulnerability to cavitation. The application of A. thaliana as a model species for xylem hydraulics provides exciting possibilities for (1) exploring the molecular basis of xylem anatomical features and (2) understanding genetic mechanisms behind xylem functional traits such as cavitation resistance. Compared to perennial woody species, however, the lesser amount of xylem in A. thaliana has its limitations.

  9. DOE/ORNL heat pump design model, overview and application to R-22 alternatives

    SciTech Connect

    Rice, C.K.

    1997-12-01

    This computer program is a public-domain system design tool for application to air-to-air heat pumps. The main aspects of the program are reviewed with emphasis on the newest features of the current fifth-generation version (Mark V) and an upcoming more fully HFC-capable release (Mark VI). Current model predictions are compared to test data for a leading HFC alternative to HCFC-22 in heat pumps. Examples are shown of some user interfaces that have been recently developed for the program. To demonstrate the design capabilities of the model for R-22 alternatives, a refrigerant-side optimization was conducted to find the best balance of heat transfer versus pressure drop for HCFC R-22, HFCs R-134a and R-410A, and the natural refrigerant propane. COP was maximized while refrigerant charge and tube size were minimized. Independent design parameters were fraction of total area in the outdoor coil, tube diameter and number of circuits for each heat exchanger, and condenser subcooling. Heat exchanger design tradeoffs are discussed for a heat pump relative to air conditioners and heating-only units. A design optimized for heating-only operation is presented.

  10. Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

    PubMed Central

    Weuster, Matthias; Mommsen, Philipp; Pfeifer, Roman; Mohr, Juliane; Ruchholtz, Steffen; Flohé, Sascha; Fröhlich, Matthias; Keibl, Claudia; Seekamp, Andreas; van Griensven, Martijn; Witte, Ingo

    2015-01-01

    Background. The deterioration of hemodynamics instantly endangers the patients' life after polytrauma. As accidental hypothermia frequently occurs in polytrauma, therapeutic hypothermia still displays an ambivalent role as the impact on the cardiopulmonary function is not yet fully understood. Methods. We have previously established a porcine polytrauma model including blunt chest trauma, penetrating abdominal trauma, and hemorrhagic shock. Therapeutic hypothermia (34°C) was induced for 3 hours. We documented cardiovascular parameters and basic respiratory parameters. Pigs were euthanized after 15.5 hours. Results. Our polytrauma porcine model displayed sufficient trauma impact. Resuscitation showed adequate restoration of hemodynamics. Induced hypothermia had neither harmful nor major positive effects on the animals' hemodynamics. Though heart rate significantly decreased and mixed venous oxygen saturation significantly increased during therapeutic hypothermia. Mean arterial blood pressure, central venous pressure, pulmonary arterial pressure, and wedge pressure showed no significant differences comparing normothermic trauma and hypothermic trauma pigs during hypothermia. Conclusions. Induced hypothermia after polytrauma is feasible. No major harmful effects on hemodynamics were observed. Therapeutic hypothermia revealed hints for tissue protective impact. But the chosen length for therapeutic hypothermia was too short. Nevertheless, therapeutic hypothermia might be a useful tool for intensive care after polytrauma. Future studies should extend therapeutic hypothermia. PMID:26170533

  11. Does the Village model help to foster age-friendly communities?

    PubMed

    Scharlach, Andrew E; Davitt, Joan K; Lehning, Amanda J; Greenfield, Emily A; Graham, Carrie L

    2014-01-01

    This article explores the potential role of the Village model, a social initiative that emphasizes member involvement and service access, in helping communities to become more age-friendly. A survey of 86.3% of operational Villages examined activities designed to help members access a variety of supports and services consistent with the World Health Organization's (WHO) Global Network of Age-Friendly Cities and Communities program model, as well as other potential contributions to community age friendliness. Analysis revealed that 85.5% of Villages provided assistance with at least six of the eight WHO domains, but only 10.1% implemented features of all eight; more than one-third were engaged in direct or indirect efforts to improve community physical or social infrastructures or improve community attitudes toward older persons. These findings suggest that Villages and other social organizations may have untapped potential for enhancing their members' ability to age in place consistent with the goals of age-friendly initiatives while also promoting constructive changes in the overall community.

  12. The Cancho i Ferrer - Solé model does not explain Zipf's Law

    NASA Astrophysics Data System (ADS)

    Dickman, Ronald; Moloney, Nicholas

    2013-03-01

    We examine the cost-minimization problem posed by Ferrer i Cancho and Solé in their information-theory based communication model, proposed in efforts to explain Zipf's Law (that is a power-law frequency-rank relation for words in written texts). Using a simple inequality, we obtain the exact minimum-cost solution as a function of the parameter λ, as obtained previously via other methods. (λ defines the relative weights of speaker's and listener's costs.) We show that at the phase transition, the minimum-cost solutions do not correspond to a power law except for a vanishingly small subset, even if we impose the additional condition of equal costs to speaker and listener. Finally we consider the model at finite temperature using mean-field theory and entropic Monte Carlo simulation, and find a line of discontinuous phase transitions in the λ- T plane. The simulations yield no evidence of a power-law frequency-rank distribution. Supported by CNPq, Brazil

  13. Modelling the mobility of living organisms in heterogeneous landscapes: does memory improve foraging success?

    PubMed

    Boyer, Denis; Walsh, Peter D

    2010-12-28

    Thanks to recent technological advances, it is now possible to track with an unprecedented precision and for long periods of time the movement patterns of many living organisms in their habitat. The increasing amount of data available on single trajectories offers the possibility of understanding how animals move and of testing basic movement models. Random walks have long represented the main description for micro-organisms and have also been useful to understand the foraging behaviour of large animals. Nevertheless, most vertebrates, in particular humans and other primates, rely on sophisticated cognitive tools such as spatial maps, episodic memory and travel cost discounting. These properties call for other modelling approaches of mobility patterns. We propose a foraging framework where a learning mobile agent uses a combination of memory-based and random steps. We investigate how advantageous it is to use memory for exploiting resources in heterogeneous and changing environments. An adequate balance of determinism and random exploration is found to maximize the foraging efficiency and to generate trajectories with an intricate spatio-temporal order, where travel routes emerge without multi-step planning. Based on this approach, we propose some tools for analysing the non-random nature of mobility patterns in general.

  14. SVC 2003 Technical Conference Summary

    SciTech Connect

    Martin, Peter M.

    2003-07-01

    The 46th Annual Technical Conference of the Society of Vacuum Coaters was held in San Francisco May 2-8. All the world events apparently did not affect the attendance or the spirit of the attendees. The Conference was a huge success and very well attended. Many feel that it was the best Techcon yet. This year's Conference really raised the bar for the 47th Annual Technical Conference in Dallas next year. Congratulations go out to the program committee, board of directors, education committee, scholarship committee and Management Plus for a job well done. Excellent accommodations were provided by the San Francisco Marriott.

  15. Control Center Technology Conference Proceedings

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Conference papers and presentations are compiled and cover evolving architectures and technologies applicable to flight control centers. Advances by NASA Centers and the aerospace industry are presented.

  16. Does littoral sand bypass the head of Mugu Submarine Canyon? - a modeling study

    USGS Publications Warehouse

    Xu, Jingping; Elias, Edwin; Kinsman, Nicole; Wang, Ping; Rosati, Julie D.; Roberts, Tiffany M.

    2011-01-01

    A newly developed sand-tracer code for the process-based model Delft3D (Deltares, The Netherlands) was used to simulate the littoral transport near the head of the Mugu Submarine Canyon in California, USA. For westerly swells, which account for more than 90% of the wave conditions in the region, the sand tracers in the downcoast littoral drift were unable to bypass the canyon head. A flow convergence near the upcoast rim of the canyon intercepts the tracers and moves them either offshore onto the shelf just west of the canyon rim (low wave height conditions) or into the canyon head (storm wave conditions). This finding supports the notion that Mugu Canyon is the true terminus of the Santa Barbara Littoral Cell.

  17. Why does service with a smile make employees happy? a social interaction model.

    PubMed

    Kim, Eugene; Yoon, David J

    2012-09-01

    Drawing on the social interaction model, we examine the mediating role that the customer's display of positive emotions plays on the relationship between the employee's display of positive emotions and the employee's positive mood. We also examine the moderating role that the customer's personality traits-agreeableness, extraversion, and emotional stability-play on the relationship between the employee's display of positive emotions and the customer's display of positive emotions. The results show that the customer's display of positive emotions mediates the relationship between the employee's display of positive emotions and the employee's positive mood. In addition, the customer's personality traits moderate the relationship between the employee's display of positive emotions and the customer's display of positive emotions. The customer's display of positive emotions depends less on the employee's display of positive emotions when the customer has high levels of agreeableness and emotional stability than when the customer has low levels of agreeableness and emotional stability. PMID:22800188

  18. Does heat acclimation improve exercise capacity at altitude? A cross-tolerance model.

    PubMed

    White, A C; Salgado, R M; Schneider, S; Loeppky, J A; Astorino, T A; Mermier, C M

    2014-11-01

    New approaches to inducing altitude acclimation in a relatively short timeframe are needed, as it is not practical for many soldiers and athletes to gain access to specialized training facilities. Acclimation to one environmental stressor could enhance adaptation to various other stressors in animals and humans. This phenomenon has been described as cross-tolerance and involves the activation of common protective pathways. The purpose of this review is to discuss possible mechanisms involved in the cross-tolerance between heat and hypoxia. Future data could potentially support the use of a cross-tolerance model as a means for military personnel to prepare for deployment to high-altitude environments, as well as for athletes competing at high altitude.

  19. Does the Biosocial Model Explain the Emergence of Status Differences in Conversations among Unacquainted Men?

    PubMed

    Mazur, Allan; Welker, Keith M; Peng, Bin

    2015-01-01

    Fifteen triads of unacquainted men conversed for ten minutes while stress was measured in real time by pulse rate and thumb blood volume (TBV). Salivary measures of testosterone (T), cortisol (C), and the stress-related enzyme alpha-amylase (AA) were measured at the beginning and end of the session. Fully or partially transitive status hierarchies formed in 14 triads. (Highest ranked man was scored 1, lowest 3, with ties allowed.) Ten of the triads participated in Study 1, where nothing was at stake in the casual conversation. Five additional triads were run in Study 2, intended to introduce competition by offering a $20 reward to the man afterward chosen as having led the conversation. Most results from the two studies are similar, suggesting that the $20 reward had little effect. Combining studies, pulse and TBV show that conversation is more stressful than watching a video beforehand. Within the conversation, speaking turns are more stressful than listening turns, especially among the lowest ranked men, less so among those higher in rank. This supports a stress-based mechanism for status allocation among humans. Apparently, human speech is a form of status signaling, homologous with nonlinguistic status signals used by other primates, as posited by the "biosocial model." The biosocial model also posits that a physiological substrate (T, C, and AA) is related to dominance or status. Predicted effects are not replicated here, except for an inverse relationship between the stress enzyme AA and status. The mostly null results, obtained from conversations where there was little or nothing at stake, suggest that T and C (and their interaction) are not relevant to emergent status in the absence of serious competition. PMID:26588849

  20. High Fidelity Virtual Environments: Does Shader Quality or Higher Polygon Count Models Increase Presence and Learning

    NASA Astrophysics Data System (ADS)

    Horton, Scott

    This research study investigated the effects of high fidelity graphics on both learning and presence, or the "sense of being there," inside a Virtual Learning Environment (VLE). Four versions of a VLE on the subject of the element mercury were created, each with a different combination of high and low fidelity polygon models and high and low fidelity shaders. A total of 76 college age (18+ years of age) participants were randomly assigned to one of the four conditions. The participants interacted with the VLE and then completed several posttest measures on learning, presence, and attitudes towards the VLE experience. Demographic information was also collected, including age, computer gameplay experience, number of virtual environments interacted with, gender and time spent in this virtual environment. The data was analyzed as a 2 x 2 between subjects ANOVA. The main effects of shader fidelity and polygon fidelity were both non-significant for both learning and all presence subscales inside the VLE. In addition, there was no significant interaction between shader fidelity and model fidelity. However, there were two significant results on the supplementary variables. First, gender was found to have a significant main effect on all the presence subscales. Females reported higher average levels of presence than their male counterparts. Second, gameplay hours, or the number of hours a participant played computer games per week, also had a significant main effect on participant score on the learning measure. The participants who reported playing 15+ hours of computer games per week, the highest amount of time in the variable, had the highest score as a group on the mercury learning measure while those participants that played 1-5 hours per week had the lowest scores.

  1. Modeling Systematic Change in Stopover Duration Does Not Improve Bias in Trends Estimated from Migration Counts

    PubMed Central

    Crewe, Tara L.; Taylor, Philip D.; Lepage, Denis

    2015-01-01

    The use of counts of unmarked migrating animals to monitor long term population trends assumes independence of daily counts and a constant rate of detection. However, migratory stopovers often last days or weeks, violating the assumption of count independence. Further, a systematic change in stopover duration will result in a change in the probability of detecting individuals once, but also in the probability of detecting individuals on more than one sampling occasion. We tested how variation in stopover duration influenced accuracy and precision of population trends by simulating migration count data with known constant rate of population change and by allowing daily probability of survival (an index of stopover duration) to remain constant, or to vary randomly, cyclically, or increase linearly over time by various levels. Using simulated datasets with a systematic increase in stopover duration, we also tested whether any resulting bias in population trend could be reduced by modeling the underlying source of variation in detection, or by subsampling data to every three or five days to reduce the incidence of recounting. Mean bias in population trend did not differ significantly from zero when stopover duration remained constant or varied randomly over time, but bias and the detection of false trends increased significantly with a systematic increase in stopover duration. Importantly, an increase in stopover duration over time resulted in a compounding effect on counts due to the increased probability of detection and of recounting on subsequent sampling occasions. Under this scenario, bias in population trend could not be modeled using a covariate for stopover duration alone. Rather, to improve inference drawn about long term population change using counts of unmarked migrants, analyses must include a covariate for stopover duration, as well as incorporate sampling modifications (e.g., subsampling) to reduce the probability that individuals will be detected on

  2. Does the Biosocial Model Explain the Emergence of Status Differences in Conversations among Unacquainted Men?

    PubMed Central

    Mazur, Allan; Welker, Keith M.; Peng, Bin

    2015-01-01

    Fifteen triads of unacquainted men conversed for ten minutes while stress was measured in real time by pulse rate and thumb blood volume (TBV). Salivary measures of testosterone (T), cortisol (C), and the stress-related enzyme alpha-amylase (AA) were measured at the beginning and end of the session. Fully or partially transitive status hierarchies formed in 14 triads. (Highest ranked man was scored 1, lowest 3, with ties allowed.) Ten of the triads participated in Study 1, where nothing was at stake in the casual conversation. Five additional triads were run in Study 2, intended to introduce competition by offering a $20 reward to the man afterward chosen as having led the conversation. Most results from the two studies are similar, suggesting that the $20 reward had little effect. Combining studies, pulse and TBV show that conversation is more stressful than watching a video beforehand. Within the conversation, speaking turns are more stressful than listening turns, especially among the lowest ranked men, less so among those higher in rank. This supports a stress-based mechanism for status allocation among humans. Apparently, human speech is a form of status signaling, homologous with nonlinguistic status signals used by other primates, as posited by the “biosocial model.” The biosocial model also posits that a physiological substrate (T, C, and AA) is related to dominance or status. Predicted effects are not replicated here, except for an inverse relationship between the stress enzyme AA and status. The mostly null results, obtained from conversations where there was little or nothing at stake, suggest that T and C (and their interaction) are not relevant to emergent status in the absence of serious competition. PMID:26588849

  3. PREFACE: 13th International Conference on Electrostatics

    NASA Astrophysics Data System (ADS)

    Taylor, D. Martin

    2011-06-01

    Ramos on 'Electrohydrodynamic pumping in microsystems'. Of the papers submitted for publication 69 passed through the thorough review process and I take this opportunity to warmly thank the reviewers for their constructive criticism and rapid turnaround which has allowed the Proceedings to be delivered to the publisher on time. It is a pleasure also to thank members of the International Advisory Panel, and the Organizing and Programme Committees for their guidance and suggestions and especially Claire Garland and her team at the Institute of Physics for their support, all of which ensured a successful and enjoyable conference. Special thanks are due to Jeremy Smallwood for organising the pre-conference workshop, to Tom Jones, Martin Glor and Dave Swenson for their highly informative and educational contributions at the workshop, to CST for organising the simulation workshop, and to CST and JCI Chilworth for their much appreciated sponsorship of the conference. I am sure you will enjoy reading this record of Electrostatics 2011, covering as it does the wide range of subjects upon which static electricity impinges. Especially important is the development of electrostatic-based methods for reducing atmospheric pollution. In this context it is interesting to see how Masuda's work on the surface-discharge-based Boxer charger, first reported over 30 years ago, has now developed into dielectric barrier discharge (DBD) systems for the removal of noxious molecules from industrial and vehicle exhaust gases. Thanks to our hard working conference chairman, Paul Holdstock, the conference retained its now well-established reputation for providing a friendly, sociable atmosphere for discussing the newest developments in this important scientific area. Finally, my sincere thanks go to all the presenters and to all those who attended and contributed to another successful conference. Professor D. Martin TaylorProceedings EditorBangor, May 2011

  4. 48 CFR 6101.11 - Conferences; conference memorandum [Rule 11].

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... agreements disposing of matters in dispute; or (6) Ways to expedite disposition of the case or to facilitate settlement of the dispute, including, if the parties and the Board agree, the use of alternative dispute... APPEALS, GENERAL SERVICES ADMINISTRATION CONTRACT DISPUTE CASES 6101.11 Conferences; conference...

  5. 48 CFR 6101.11 - Conferences; conference memorandum [Rule 11].

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... agreements disposing of matters in dispute; or (6) Ways to expedite disposition of the case or to facilitate settlement of the dispute, including, if the parties and the Board agree, the use of alternative dispute... APPEALS, GENERAL SERVICES ADMINISTRATION CONTRACT DISPUTE CASES 6101.11 Conferences; conference...

  6. (Tribology conferences and forums)

    SciTech Connect

    Yust, C.S.

    1990-11-30

    The principal meeting attended during this trip was the Japan International Tribology Conference Nagoya 1990. The conference encompassed a wide range of topics, including the tribology of ceramics, the tribology in high-performance automobiles, and many aspects of lubrication technology. Associated forums were also held on the tribology of advanced ceramics, on solid lubrication, and on automotive lubricants. Presentations made during the latter forum discussed anticipated trends in engine development and anticipated improvements in lubricants required for the next generation of engines. In addition to meetings, site visits were made to five industrial organizations to discuss ceramic tribology. Nippon Steel Corporation and Toshiba Corporation are both very active in the ceramic area, Nippon Steel from their interest in research on new materials and Toshiba from both an interest in new materials and in support of their work in electronic devices. Two engine manufacturers were also visited, Toyota Motor Corporation, and Nissan Motor Co., Ltd. These companies were somewhat reserved in their discussion of progress in the utilization of ceramics in automobile engines.

  7. History of NAMES Conferences

    NASA Astrophysics Data System (ADS)

    Filippov, Lev

    2013-03-01

    -Russian International Centre was demonstrated. By the high standards of the reports presented, as well as by its overall organization, the second Seminar met the standards of an international conference. Reviews of state-of-the-art developments in materials science were given by leading scientists from Moscow and from the Lorraine region. The three days of the seminar were structured into four main themes: Functional Materials Coatings, Films and Surface Engineering Nanomaterials and Nanotechnologies The Environment and three Round Table discussions: Defining practical means of carrying out Franco-Russian collaborations in technology transfer and innovation Materials science ARCUS: Lorraine-Russian collaboration in materials science and the environment 32 oral and 25 poster presentations within four sections were given by a total of 110 participants. NAMES 2007, the 3rd Franco-Russian Seminar on New Achievements in Materials and Environmental Sciences, took place in Metz, France on 7-9 November 2007. The conference highlights fundamentals and development of the five main themes connected to the Lorraine-Russia ARCUS project with possible extension to other topics. The five main subjects included in the ARCUS project are: Bulk-surface-interface material sciences Nanomaterials and nanotechnologies Environment and natural resources Plasma physics—ITER project Vibrational dynamics The first, second and third NAMES conferences were financially supported by the following organizations: Ambassade de France à Moscou Communauté Urbaine du Grand Nancy Région Lorraine Conseil Général de Meurthe et Moselle Institut National Polytechnique de Lorraine Université de Metz Université Henry Poincaré CNRS ANVAR Federal Agency on Science and Innovations of the Ministry of Education and Science of the Russian Federation Moscow Committee on Science and Technologies Moscow Institute of Steel and Alloys (Technological University) The 4th conference is supported by the Ministry of Foreign Affairs of

  8. 76 FR 57746 - Conference on the International Conference on Harmonisation Q10 Pharmaceutical Quality System: A...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... Q10 Pharmaceutical Quality System: A Practical Approach to Effective Life- Cycle Implementation of...) Conference: A Practical Approach to Effective Life- Cycle Implementation of Systems and Processes for... product life cycle according to the ICH Q10 model. These companies are reaping the benefits that come...

  9. 44th Annual Anomalous Absorption Conference

    SciTech Connect

    Beg, Farhat

    2014-03-03

    beyond ICF-related laser-plasma interactions to encompass closely related technical areas including laser particle acceleration, high-intensity laser effects, short­ pulse laser interactions, PIC and Vlasov/rad-hydro modeling, inertial and magnetic fusion plasmas, advanced plasma diagnostics, alternate ignition schemes, EOS/transport/opacity, and this year, x­ ray free-electron lasers and their applications. The conference continues to be a showcase for the presentation and discussion of the latest developments in these areas. II. Meeting Report The conference was extremely successful with more than one hundred participants. There were ninety-nine (99) abstracts submitted. There were forty-four (44) presentations including eleven (11) invited talks. The following topics were covered: a) Radiation Hydrodynamics b) Implosion Plasma Kinetic Effects c) Alternate Ignition Schemes d) Astrophysical Phenomena e) Opacity/Transport/EOS f) High Power Lasers and Facilities g) High-Intensity Laser-Matter Interactions h) Hydrodynamics and Hydro-instabilities i) Hot Dense Plasma Atomic Processes j) High Energy Density Physics k) Laser Particle Acceleration Physics l) Advanced Plasma Diagnostics m) Advanced light sources and applications Despite significant advertising, there were two students who applied for the travel grants: Charlie Jarrott and Joohwan Kim. The total funds expended were $3,216.14.

  10. Structure Model Index Does Not Measure Rods and Plates in Trabecular Bone

    PubMed Central

    Salmon, Phil L.; Ohlsson, Claes; Shefelbine, Sandra J.; Doube, Michael

    2015-01-01

    Structure model index (SMI) is widely used to measure rods and plates in trabecular bone. It exploits the change in surface curvature that occurs as a structure varies from spherical (SMI = 4), to cylindrical (SMI = 3) to planar (SMI = 0). The most important assumption underlying SMI is that the entire bone surface is convex and that the curvature differential is positive at all points on the surface. The intricate connections within the trabecular continuum suggest that a high proportion of the surface could be concave, violating the assumption of convexity and producing regions of negative differential. We implemented SMI in the BoneJ plugin and included the ability to measure the amounts of surface that increased or decreased in area after surface mesh dilation, and the ability to visualize concave and convex regions. We measured SMI and its positive (SMI+) and negative (SMI−) components, bone volume fraction (BV/TV), the fraction of the surface that is concave (CF), and mean ellipsoid factor (EF) in trabecular bone using 38 X-ray microtomography (XMT) images from a rat ovariectomy model of sex steroid rescue of bone loss, and 169 XMT images from a broad selection of 87 species’ femora (mammals, birds, and a crocodile). We simulated bone resorption by eroding an image of elephant trabeculae and recording SMI and BV/TV at each erosion step. Up to 70%, and rarely <20%, of the trabecular surface is concave (CF 0.155–0.700). SMI is unavoidably influenced by aberrations induced by SMI−, which is strongly correlated with BV/TV and CF. The plate-to-rod transition in bone loss is an erroneous observation resulting from the close and artifactual relationship between SMI and BV/TV. SMI cannot discern between the distinctive trabecular geometries typical of mammalian and avian bone, whereas EF clearly detects birds’ more plate-like trabeculae. EF is free from confounding relationships with BV/TV and CF. SMI results reported in the literature should be

  11. Heterostegina depressa growth model: what does cell volume tell us about biogeography and ecology?

    NASA Astrophysics Data System (ADS)

    Eder, Wolfgang; Kinoshita, Shunichi; Woeger, Julia; Hohenegger, Johann; Briguglio, Antonino; Ferrandez-Canadell, Carles

    2015-04-01

    The foraminiferal subfamily Heterostegininae has been the centre of interest of many interdisciplinary studies in the last decades. Some of them reviewing only taxonomic criteria used to identify the different lineages by application of classical two dimensional biometry, while others focussing on more biological interests. This study tries to integrate new means of three-dimensional quantification on biometry used in micropalaeontology. By applying Micro-computed tomography (µCT) each chamber's volume of the foraminiferal test can be extracted and used to quantify and model the cell growth of larger benthic Foraminifera. This work concentrated on the single but abundant extant representative of the Heterostegina lineage (sensu d'Orbigny), H. depressa, studying the growth in specimens from two natural populations, Okinawa (Japan) and Maui (Hawaii), and from laboratory cultures (offspring of the Hawaiian population). Data obtained from measurements of the volume of the 25 initial chambers were fitted to a theoretical growth model using an exponential function. Two parameters of this function, a (= initial size) and b (= growth rate) were observed to reflect distinct information related to the either provenance or the ecology of the populations. The parameter a represents the proloculus size, which is frequently used in its two dimensional form (equatorial diameter) as a biometrical significant parameter. When comparing the proloculus volume in specimens of the three samples, a distinctive trend becomes visible: All specimens from a single locality group together, while laboratory cultured individuals are more similar to their relatives from Hawaii (with which they share the gene pool) than those from Okinawa. Proloculus volume is thus more influenced by internal (genetic) factors than to external (ecological) ones. Parameter b shows a different trend, related to the intensity of growth. The naturally grown specimens from different geographic localities show higher

  12. Lexical plasticity in early bilinguals does not alter phoneme categories: I. Neurodynamical modeling.

    PubMed

    Larsson, J P; Constán, Fátima Vera; Sebastián-Gallés, Núria; Deco, Gustavo

    2008-01-01

    Abstract Sebastián-Gallés et al. [The influence of initial exposure on lexical representation: Comparing early and simultaneous bilinguals. Journal of Memory and Language, 52, 240-255, 2005] contrasted highly proficient early Spanish-Catalan and Catalan-Spanish bilinguals, using Catalan materials in a lexical decision task (LDT). They constructed two types of experimental pseudowords, substituting Catalan phoneme /e/ for Catalan /epsilon/, or vice versa. Catalan-dominant bilinguals showed a performance asymmetry across experimental conditions, making more mistakes for /epsilon/-->/e/ changes, than for /e/-->/epsilon/ ones. This was considered evidence of a developed acceptance of mispronounced Catalan /epsilon/-words, caused by exposure to a bilingual environment where mispronunciations by Spanish-dominant bilinguals using their /e/-category abound. Although this indicated modified or added lexical representations, an open issue is whether such lexical information also modifies phoneme categories. We address this using a biophysically realistic neurodynamic model, describing neural activity at the synaptic and spiking levels. We construct a network of pools of neurons, representing phonemic and lexical processing. Carefully analyzing the dependency of network dynamics on connection strengths, by first exploring parameter space under steady-state assumptions (mean-field scans), then running spiking simulations, we investigate the neural substrate role in a representative LDT. We also simulate a phoneme discrimination task to address whether lexical changes affect the phonemic level. We find that the same network configuration which displays asymmetry in the LDT shows equal performance discriminating the two modeled phonemes. Thus, we predicted that the Catalan-dominant bilinguals do not alter their phoneme categories, although showing signs of having stored a new word variation in the lexicon. To explore this prediction, a syllable discrimination task involving

  13. Structure Model Index Does Not Measure Rods and Plates in Trabecular Bone.

    PubMed

    Salmon, Phil L; Ohlsson, Claes; Shefelbine, Sandra J; Doube, Michael

    2015-01-01

    Structure model index (SMI) is widely used to measure rods and plates in trabecular bone. It exploits the change in surface curvature that occurs as a structure varies from spherical (SMI = 4), to cylindrical (SMI = 3) to planar (SMI = 0). The most important assumption underlying SMI is that the entire bone surface is convex and that the curvature differential is positive at all points on the surface. The intricate connections within the trabecular continuum suggest that a high proportion of the surface could be concave, violating the assumption of convexity and producing regions of negative differential. We implemented SMI in the BoneJ plugin and included the ability to measure the amounts of surface that increased or decreased in area after surface mesh dilation, and the ability to visualize concave and convex regions. We measured SMI and its positive (SMI(+)) and negative (SMI(-)) components, bone volume fraction (BV/TV), the fraction of the surface that is concave (CF), and mean ellipsoid factor (EF) in trabecular bone using 38 X-ray microtomography (XMT) images from a rat ovariectomy model of sex steroid rescue of bone loss, and 169 XMT images from a broad selection of 87 species' femora (mammals, birds, and a crocodile). We simulated bone resorption by eroding an image of elephant trabecule and recording SMI and BV/TV at each erosion step. Up to 70%, and rarely <20%, of the trabecular surface is concave (CF 0.155-0.700). SMI is unavoidably influenced by aberrations induced by SMI(-), which is strongly correlated with BV/TV and CF. The plate-to-rod transition in bone loss is an erroneous observation resulting from the close and artifactual relationship between SMI and BV/TV. SMI cannot discern between the distinctive trabecular geometries typical of mammalian and avian bone, whereas EF clearly detects birds' more plate-like trabecule. EF is free from confounding relationships with BV/TV and CF. SMI results reported in the literature should be

  14. Structure Model Index Does Not Measure Rods and Plates in Trabecular Bone.

    PubMed

    Salmon, Phil L; Ohlsson, Claes; Shefelbine, Sandra J; Doube, Michael

    2015-01-01

    Structure model index (SMI) is widely used to measure rods and plates in trabecular bone. It exploits the change in surface curvature that occurs as a structure varies from spherical (SMI = 4), to cylindrical (SMI = 3) to planar (SMI = 0). The most important assumption underlying SMI is that the entire bone surface is convex and that the curvature differential is positive at all points on the surface. The intricate connections within the trabecular continuum suggest that a high proportion of the surface could be concave, violating the assumption of convexity and producing regions of negative differential. We implemented SMI in the BoneJ plugin and included the ability to measure the amounts of surface that increased or decreased in area after surface mesh dilation, and the ability to visualize concave and convex regions. We measured SMI and its positive (SMI(+)) and negative (SMI(-)) components, bone volume fraction (BV/TV), the fraction of the surface that is concave (CF), and mean ellipsoid factor (EF) in trabecular bone using 38 X-ray microtomography (XMT) images from a rat ovariectomy model of sex steroid rescue of bone loss, and 169 XMT images from a broad selection of 87 species' femora (mammals, birds, and a crocodile). We simulated bone resorption by eroding an image of elephant trabecule and recording SMI and BV/TV at each erosion step. Up to 70%, and rarely <20%, of the trabecular surface is concave (CF 0.155-0.700). SMI is unavoidably influenced by aberrations induced by SMI(-), which is strongly correlated with BV/TV and CF. The plate-to-rod transition in bone loss is an erroneous observation resulting from the close and artifactual relationship between SMI and BV/TV. SMI cannot discern between the distinctive trabecular geometries typical of mammalian and avian bone, whereas EF clearly detects birds' more plate-like trabecule. EF is free from confounding relationships with BV/TV and CF. SMI results reported in the literature should be

  15. Does amniotic fluid volume affect fetofetal transfusion in monochorionic twin pregnancies? Modelling two possible mechanisms

    NASA Astrophysics Data System (ADS)

    Umur, Asli; van Gemert, Martin J. C.; Ross, Michael G.

    2002-06-01

    Clinical evidence suggests that increased amniotic fluid volume due to polyhydramnios increases placental vascular resistance. We have sought to model the possible effects of an increased amniotic fluid volume on the net fetofetal transfusion in monochorionic twin pregnancies. We wanted to compare these effects with the results of previous simulations, which aimed to explain why the twin-twin transfusion syndrome (TTTS) placentas more often include bidirectional arteriovenous (AV) rather than AV plus arterioarterial (AA) anastomoses. We extended our mathematical model of TTTS by simulating two different mechanisms that increase the placental vascular resistance as a consequence of polyhydramnios. First, there is an increase in the placental capillary resistance and hence in deep AV and opposite AV (denoted as VA) resistances due to polyhydramnios. Second, there is an increase in the resistance of chorionic veins due to polyhydramnios, assuming that these veins act as Starling resistors. We then simulated the effects of polyhydramnios on different placental anastomotic patterns. The results were as follows. In the first mechanism (polyhydramnios affects AV-VA resistances), an increased amniotic fluid volume hardly affected bidirectional AV, but slightly decreased fetofetal transfusion in AV plus AA anastomoses. However, for these effects to change the natural development of the pregnancy, polyhydramnios needed to persist for approximately 4 weeks, and by comparing the effects of polyhydramnios with the effects of amnioreduction, amnioreduction was more beneficial for normalizing the donor amniotic fluid volume. Therefore, these beneficial effects due to polyhydramnios have no practical clinical significance. In the second mechanism (Starling resistor for chorionic veins), polyhydramnios slightly increased fetofetal transfusion and hence slightly increased TTTS severity in bidirectional AV and AV plus VV, but did not affect AV plus AA anastomoses. In conclusion, we

  16. Vaccination with intestinal tract antigens does not induce protective immunity in a permissive model of filariasis.

    PubMed

    Morris, C Paul; Torrero, Marina N; Larson, David; Evans, Holly; Shi, Yinghui; Cox, Rachel T; Mitre, Edward

    2013-09-01

    Antigens obtained from the intestinal tract of filarial nematodes have been proposed as potential safe and effective vaccine candidates. Because they may be 'hidden' from the immune response during natural infection, yet accessible by antibodies induced by vaccination, intestinal antigens may have a low potential for eliciting allergic responses when vaccinating previously infected individuals. Despite prior promising data, vaccination with intestinal antigens has yet to be tested in a permissive model of filariasis. In this study we investigated the efficacy of vaccination with filarial intestinal antigens in the permissive Litomosoides sigmodontis BALB/c model of filariasis, and we evaluated the extent to which these antigens are recognized by the immune system during and after infection. Infected BALB/c mice developed lower IgG antibody responses to soluble intestinal antigens (GutAg) than to soluble antigens of whole worms (LsAg). Similarly, GutAg induced less proliferation and less production of IL-4 and IFNγ from splenocytes of infected mice than LsAg. In contrast to these differences, active infection resulted in equivalent levels of circulating GutAg-specific IgE and LsAg-specific IgE levels. Consistent with this, basophil activation, as assessed by flow cytometric staining of intracellular basophil IL-4 expression, was equivalent in response to GutAg and LsAg. Vaccination with GutAg adsorbed to CpG/alum induced GutAg specific IgG1 and IgG2A production, with GutAg specific IgG titers greater than 5-fold higher than those measured in previously infected animals. Despite this response to GutAg vaccination, vaccinated mice harbored similar parasite burdens 8 weeks post infection when compared to non-vaccinated controls. These studies demonstrate that soluble antigens obtained from the intestinal tracts of L. sigmodontis have some qualities of 'hidden' antigens, but they still sensitize mice to allergic reactions and fail to protect against future infection

  17. History of NAMES Conferences

    NASA Astrophysics Data System (ADS)

    Filippov, Lev

    2013-03-01

    -Russian International Centre was demonstrated. By the high standards of the reports presented, as well as by its overall organization, the second Seminar met the standards of an international conference. Reviews of state-of-the-art developments in materials science were given by leading scientists from Moscow and from the Lorraine region. The three days of the seminar were structured into four main themes: Functional Materials Coatings, Films and Surface Engineering Nanomaterials and Nanotechnologies The Environment and three Round Table discussions: Defining practical means of carrying out Franco-Russian collaborations in technology transfer and innovation Materials science ARCUS: Lorraine-Russian collaboration in materials science and the environment 32 oral and 25 poster presentations within four sections were given by a total of 110 participants. NAMES 2007, the 3rd Franco-Russian Seminar on New Achievements in Materials and Environmental Sciences, took place in Metz, France on 7-9 November 2007. The conference highlights fundamentals and development of the five main themes connected to the Lorraine-Russia ARCUS project with possible extension to other topics. The five main subjects included in the ARCUS project are: Bulk-surface-interface material sciences Nanomaterials and nanotechnologies Environment and natural resources Plasma physics—ITER project Vibrational dynamics The first, second and third NAMES conferences were financially supported by the following organizations: Ambassade de France à Moscou Communauté Urbaine du Grand Nancy Région Lorraine Conseil Général de Meurthe et Moselle Institut National Polytechnique de Lorraine Université de Metz Université Henry Poincaré CNRS ANVAR Federal Agency on Science and Innovations of the Ministry of Education and Science of the Russian Federation Moscow Committee on Science and Technologies Moscow Institute of Steel and Alloys (Technological University) The 4th conference is supported by the Ministry of Foreign Affairs of

  18. Calendar of Conferences

    NASA Astrophysics Data System (ADS)

    1996-08-01

    8 - 18 August 1996 International Summer School on Plasma Physics and Technology La Jolla, CA, USA Contact: Mr V Stefan, Institute for Advanced Physics Studies, PO Box 2964, La Jolla, CA 92038, USA. Tel +1-619-456-5737. 26 - 30 August 1996 Joint Varenna - Lausanne International Workshop on Theory of Fusion Plasmas Villa Monastero, Varenna, Italy Contact: Centro di Cultura Villa Monastero, 1 Piazza Venini, 22050 Varenna (Lecco), Italy. Tel +39-341-831261, Fax +39-341-831281. Application and abstract deadline: 15 June 1996. 2 - 5 September 1996 EU - US Workshop on Transport in Fusion Plasmas Villa Monastero, Varenna, Italy Further information: G Gorini, ISPP, 16 Via Celoria, I-20133 Milano, Italy. Tel +39-2-2392637, Fax +39-2-2392205, E-mail ggorini@mi.infn.it. Administrative contact: Centro di Cultura Villa Monastero, 1 Piazza Venini, 22050 Varenna (Lecco), Italy. Tel +39-341-831261, Fax +39-341-831281. Application and abstract deadline: 15 June 1996. 9 - 13 September 1996 International Conference on Plasma Physics Nagoya, Japan Contact: Conference Secretariat, c/o Prof. Hiromu Momota, National Institute for Fusion Science, Nagoya 464-01, Japan. Tel +81-52-789-4260, Fax +81-52-789-1037, E-mail icpp96@nifs.ac.jp. Abstract deadline: 31 March 1996. 16 - 20 September 1996 19th Symposium on Fusion Technology Lisbon, Portugal Contact: Professor Carlos Varandas, Centro de Fusão Nuclear, 1096 Lisboa Codex, Portugal. Fax +351-1-8417819, E-mail cvarandas@cfn.ist.utl.pt. General information will be available via WWW with URL http://www.cfn.ist.utl.pt. 25 - 29 September 1996 Summer University of Plasma Physics Garching, Germany Contact: Ms Ch Stahlberg, Max-Planck-Institut für PlasmaPhysik, Boltzmannstr 2, D-85748 Garching, Germany. Tel +49-89-3299-2232, Fax +49-89-3299-1001. 11 - 15 November 1996 38th Annual Meeting of the Division of Plasma Physics, APS Denver, CO, USA Contact: Dr Richard Hazeltine, University of Texas

  19. Abatacept Treatment Does Not Preserve Renal Function in the Streptozocin-Induced Model of Diabetic Nephropathy

    PubMed Central

    Helding Kvist, Peter; Douglas Galsgaard, Elisabeth; Coppieters, Ken

    2016-01-01

    Diabetic nephropathy (DN) is one of the most severe complications of diabetes and remains the largest cause of end-stage renal disease in the Western world. Treatment options are limited and novel therapies that effectively slow disease progression are warranted. Previous work suggested that treatment with CTLA4-Ig (abatacept), a molecule that binds and blocks B7-1 and is licensed for the treatment of rheumatoid arthritis, could ameliorate DN. This study was designed to assess whether B7-1 signalling constitutes a promising therapeutic pathway for DN. Mice injected with streptozotocin (STZ) were treated with abatacept and glycemia and renal function were assessed. No differences were found in diabetes progression, albumin excretion rates or albumin/creatine ratios, while mesangial expansion was unaltered at endpoint. Except for increased renal CCL5, treatment did not affect a panel of gene expression endpoints reflecting early fibrotic changes, inflammation and kidney injury. Finally, abatacept treatment effectively reduced the accumulation of activated CD4+ T cells in the kidney, suggesting that renal T cell inflammation is not a driving factor in the pathology of the STZ model. In conjunction with the recent data discounting the expression of B7-1 on podocytes, our present data do not support a role for abatacept in DN treatment. PMID:27055155

  20. Lysophosphatidic acid does not cause blood/lymphatic vessel plasticity in the rat mesentery culture model.

    PubMed

    Sweat, Richard S; Azimi, Mohammad S; Suarez-Martinez, Ariana D; Katakam, Prasad; Murfee, Walter L

    2016-07-01

    Understanding the mechanisms behind endothelial cell identity is crucial for the goal of manipulating microvascular networks. Lysophosphatidic acid (LPA) and serum stimulation have been suggested to induce a lymphatic identity in blood endothelial cells in vitro. The objective of this study was to determine if LPA or serum induces blood-to-lymphatic vessel phenotypic transition in microvascular networks. The rat mesentery culture model was used to observe the effect of stimulation on blood and lymphatic microvascular networks ex vivo. Vascularized mesenteric tissues were harvested from adult Wistar rats and cultured with LPA or 10% serum for up to 5 days. Tissues were then immunolabeled with PECAM to identify blood vessels and LYVE-1 or Prox1 to identify lymphatic vessels. We show that while LPA caused capillary sprouting and increased vascular length density in adult microvascular networks, LPA did not cause a blood-to-lymphatic phenotypic transition. The results suggest that LPA is not sufficient to cause blood endothelial cells to adopt a lymphatic identity in adult microvascular networks. Similarly, serum stimulation caused robust angiogenesis and increased lymphatic/blood vessel connections, yet did not induce a blood-to-lymphatic phenotypic transition. Our study highlights an understudied area of lymphatic research and warrants future investigation into the mechanisms responsible for the maintenance of blood and lymphatic vessel identity. PMID:27401461

  1. Abatacept Treatment Does Not Preserve Renal Function in the Streptozocin-Induced Model of Diabetic Nephropathy.

    PubMed

    Norlin, Jenny; Nielsen Fink, Lisbeth; Helding Kvist, Peter; Douglas Galsgaard, Elisabeth; Coppieters, Ken

    2016-01-01

    Diabetic nephropathy (DN) is one of the most severe complications of diabetes and remains the largest cause of end-stage renal disease in the Western world. Treatment options are limited and novel therapies that effectively slow disease progression are warranted. Previous work suggested that treatment with CTLA4-Ig (abatacept), a molecule that binds and blocks B7-1 and is licensed for the treatment of rheumatoid arthritis, could ameliorate DN. This study was designed to assess whether B7-1 signalling constitutes a promising therapeutic pathway for DN. Mice injected with streptozotocin (STZ) were treated with abatacept and glycemia and renal function were assessed. No differences were found in diabetes progression, albumin excretion rates or albumin/creatine ratios, while mesangial expansion was unaltered at endpoint. Except for increased renal CCL5, treatment did not affect a panel of gene expression endpoints reflecting early fibrotic changes, inflammation and kidney injury. Finally, abatacept treatment effectively reduced the accumulation of activated CD4+ T cells in the kidney, suggesting that renal T cell inflammation is not a driving factor in the pathology of the STZ model. In conjunction with the recent data discounting the expression of B7-1 on podocytes, our present data do not support a role for abatacept in DN treatment. PMID:27055155

  2. Access to a responsiveness to intervention model: does beginning intervention in kindergarten matter?

    PubMed

    O'Connor, Rollanda E; Bocian, Kathleen M; Sanchez, Victoria; Beach, Kristen D

    2014-01-01

    In this study, we tested the outcomes of access to a response to intervention (RtI) model in kindergarten or in first grade on end-of-Grade-2 reading achievement and placement in special education. Across five schools, 214 students who began having access to Tier 2 intervention in kindergarten or first grade were compared in Grades 1 and 2 with 208 cohort peers who were average readers and 102 historical control condition second grade poor readers who did not receive Tier 2 intervention. Results demonstrated significant effects on reading achievement for access to RtI in kindergarten at the end of first grade (effects averaged 0.48), but not in second grade, except for students who were English language learners (ELLs), who showed an advantage through the end of second grade. Students with access to RtI overall had significantly higher outcomes at the end of Grade 2 than students in the historical control, with no differences resulting from ELL status. No significant difference in the proportion of students placed in special education was noted; however, a greater proportion of the students found eligible as with learning disabilities had poor reading scores if they were placed after participating in RtI. PMID:23019070

  3. Abatacept Treatment Does Not Preserve Renal Function in the Streptozocin-Induced Model of Diabetic Nephropathy.

    PubMed

    Norlin, Jenny; Nielsen Fink, Lisbeth; Helding Kvist, Peter; Douglas Galsgaard, Elisabeth; Coppieters, Ken

    2016-01-01

    Diabetic nephropathy (DN) is one of the most severe complications of diabetes and remains the largest cause of end-stage renal disease in the Western world. Treatment options are limited and novel therapies that effectively slow disease progression are warranted. Previous work suggested that treatment with CTLA4-Ig (abatacept), a molecule that binds and blocks B7-1 and is licensed for the treatment of rheumatoid arthritis, could ameliorate DN. This study was designed to assess whether B7-1 signalling constitutes a promising therapeutic pathway for DN. Mice injected with streptozotocin (STZ) were treated with abatacept and glycemia and renal function were assessed. No differences were found in diabetes progression, albumin excretion rates or albumin/creatine ratios, while mesangial expansion was unaltered at endpoint. Except for increased renal CCL5, treatment did not affect a panel of gene expression endpoints reflecting early fibrotic changes, inflammation and kidney injury. Finally, abatacept treatment effectively reduced the accumulation of activated CD4+ T cells in the kidney, suggesting that renal T cell inflammation is not a driving factor in the pathology of the STZ model. In conjunction with the recent data discounting the expression of B7-1 on podocytes, our present data do not support a role for abatacept in DN treatment.

  4. Encouraging Girls into Science and Technology with Feminine Role Model: Does This Work?

    NASA Astrophysics Data System (ADS)

    Bamberger, Yael M.

    2014-08-01

    This study examines the effect of a program that aimed to encourage girls to choose a science, technology, engineering, and mathematics (STEM) career in Israel. The program involved school visits to a high-tech company and meeting with role model female scientists. Sixty ninth-grade female students from a Jewish modern-orthodox single-sex secondary school in the same city as the company participated in the study. The control group contained 30 girls from the same classes who did not participate in the program. Data were collected through pre-post questionnaires, observations, and focus group interviews. It was analyzed for three main themes: perceptions of scientists and engineers, capability of dealing with STEM, and future career choice. Findings indicated respect toward the women scientists as being smart and creative, but significant negative change on the perceptions of women scientists/engineers, the capability of dealing with STEM, and the STEM career choices. Possible causes for these results are discussed, as well as implications for education.

  5. [Nicotine and animal models: what does the environmental enrichment paradigm tell us?].

    PubMed

    Mesa-Gresa, Patricia; Pérez-Martínez, Asunción; Redolat-Iborra, Rosa

    2012-01-01

    The Environmental Enrichment (EE) paradigm is a housing condition which aims is to provide physical, cognitive and sensorial stimulation to rodents. Animals are housed in larger cages containing inanimate objects such as tunnels, toys and running wheels. The main aim of the current work is to tackle the arguments which suggest that EE may diminish vulnerability to developing addiction to nicotine and other drugs of abuse and to review recent experimental studies performed in relation to this subject. We discuss the major changes induced by EE at physical, neurobiological and behavioral levels and review the results of recent studies which indicate that EE promotes both neurochemical (potentiation of the increase in dopamine release induced by nicotine in the brain cortex) and behavioral changes (increased ability to discriminate the presence of reward and decreased impulsivity), thus supporting the hypothesis put forward. In light of these results, EE can be proposed as a model for the study of vulnerability to addiction to different drugs of abuse, including cocaine and nicotine, though further studies are needed in order to establish the neurobiological implications of the effects of exposure to enriched environments and their possible relationship with changes in brain reward systems. PMID:22648311

  6. Lysophosphatidic acid does not cause blood/lymphatic vessel plasticity in the rat mesentery culture model.

    PubMed

    Sweat, Richard S; Azimi, Mohammad S; Suarez-Martinez, Ariana D; Katakam, Prasad; Murfee, Walter L

    2016-07-01

    Understanding the mechanisms behind endothelial cell identity is crucial for the goal of manipulating microvascular networks. Lysophosphatidic acid (LPA) and serum stimulation have been suggested to induce a lymphatic identity in blood endothelial cells in vitro. The objective of this study was to determine if LPA or serum induces blood-to-lymphatic vessel phenotypic transition in microvascular networks. The rat mesentery culture model was used to observe the effect of stimulation on blood and lymphatic microvascular networks ex vivo. Vascularized mesenteric tissues were harvested from adult Wistar rats and cultured with LPA or 10% serum for up to 5 days. Tissues were then immunolabeled with PECAM to identify blood vessels and LYVE-1 or Prox1 to identify lymphatic vessels. We show that while LPA caused capillary sprouting and increased vascular length density in adult microvascular networks, LPA did not cause a blood-to-lymphatic phenotypic transition. The results suggest that LPA is not sufficient to cause blood endothelial cells to adopt a lymphatic identity in adult microvascular networks. Similarly, serum stimulation caused robust angiogenesis and increased lymphatic/blood vessel connections, yet did not induce a blood-to-lymphatic phenotypic transition. Our study highlights an understudied area of lymphatic research and warrants future investigation into the mechanisms responsible for the maintenance of blood and lymphatic vessel identity.

  7. Minitrack on data and knowledge base issues in genomics at the 27th Hawaii International Conference on system sciences

    SciTech Connect

    1995-05-01

    This report is a summary of the proceedings from the Minitrack on Data and Knowledge Base Issues in Genomics at the 27th Hawaii International Conference on System Science, January 4 - 7, 1994. The minitrack was organized by Dong-Guk Shin (University of Connecticut) and Francois Rechenmann (INRIA, France). Support was jointly provided by the NSF, NIH and DOE. The minitrack included, after rigorous review, ten full papers and four extended abstracts in the following five different research subareas of genome informatics: data modeling and management, sequence analysis, graphical user interface, interoperation in a heterogenous computing environment, and system integration in a knowledge-based approach.

  8. Proceedings of the NASA Conference on Space Telerobotics, volume 5

    NASA Technical Reports Server (NTRS)

    Rodriguez, Guillermo (Editor); Seraji, Homayoun (Editor)

    1989-01-01

    Papers presented at the NASA Conference on Space Telerobotics are compiled. The theme of the conference was man-machine collaboration in space. The conference provided a forum for researchers and engineers to exchange ideas on the research and development required for the application of telerobotics technology to the space systems planned for the 1990's and beyond. Volume 5 contains papers related to the following subject areas: robot arm modeling and control, special topics in telerobotics, telerobotic space operations, manipulator control, flight experiment concepts, manipulator coordination, issues in artificial intelligence systems, and research activities at the Johnson Space Center.

  9. Does Low-intensity pulsed ultrasound treatment repair articular cartilage injury? A rabbit model study

    PubMed Central

    2014-01-01

    Background Low-intensity pulsed ultrasound (LIPUS) regiment has been used to treat fractures with non-union and to promote bone union in general. The effect of LIPUS on articular cartilage metabolism has been characterized. Yet, the effect of LIPUS to repair articular cartilage injury remains unclear in vivo. Methods We designed a study to investigate the effect of LIPUS on articular cartilage repairing in a rabbit severe cartilage injury model. Eighteen rabbits were divided into three groups: Sham-operated group, operated group without-LIPUS-treatment, operated group with-LIPUS-treatment (a daily 20-minute treatment for 3 months). Full-thickness cartilage defects were surgically created on the right side distal femoral condyle without intending to penetrate into the subchondral bone, which mimicked severe chondral injury. MR images for experimental joints, morphology grading scale, and histopathological Mankin score were evaluated. Results The preliminary results showed that the operated groups with-LIPUS-treatment and without-LIPUS-treatment had significantly higher Mankin score and morphological grading scale compared with the sham-operated group. However, there was no significant difference between the with-LIPUS-treatment and without-LIPUS-treatment groups. Cartilage defects filled with proliferative tissue were observed in the with-LIPUS-treatment group grossly and under MR images, however which presented less up-take under Alcian blue stain. Furthermore, no new deposition of type II collagen or proliferation of chondrocyte was observed over the cartilage defect after LIPUS treatment. Conclusion LIPUS has no significant therapeutic potential in treating severe articular cartilage injury in our animal study. PMID:24507771

  10. Does glutamine reduce bacterial translocation? A study in two animal models with impaired gut barrier.

    PubMed

    Foitzik, T; Kruschewski, M; Kroesen, A J; Hotz, H G; Eibl, G; Buhr, H J

    1999-08-01

    Failure of intestinal barrier function and subsequent translocation of bacteria from the gut are believed to play a decisive role in the development of systemic septic complications, for example, following major trauma or major abdominal surgery. This study evaluated: (a) the effect of glutamine on colonic microcirculation and electrophysiological parameters reflecting gut barrier function, (b) the translocation of live bacteria to extraintestinal organs, and (c) disease outcome in two animal models with impaired gut barrier function. Severe acute pancreatitis or colitis was induced in rats randomized for therapy with or without glutamine (0.5 g/kg daily). After 48 h one animal group was prepared for intravital microscopy of colonic capillary blood flow and electrophysiological measurement of gut permeability; another was killed after 96 h for histological and microbiological examination. In animals with pancreatitis, glutamine (Gln) supplementation significantly improved gut permeability, i.e., Gln increased colonic transmucosal resistance from 67+/-7 to 92+/-3 Omega/cm(2) and decreased mannitol flux through the epithelium by 53%. Capillary blood flow in the colonic mucosa was improved by 25%. The prevalence of pancreatic infections was reduced from 86% in animals on standard parenteral nutrition to 33% in animals given the Gln-enriched diet (P<0.05); mortality decreased by 32%. In colitis, Gln had no significant effect on these parameters except for improving colonic capillary blood flow in colon segments not adjacent to the major injury site. Glutamine supplementation improves colonic capillary blood flow, stabilizes gut permeability, and reduces secondary pancreatic infections and mortality in severe rodent pancreatitis, but it is not helpful in colitis. This confirms previous reports that glutamine stabilizes gut barrier function only in certain diseases. Our experimental data strongly suggest that acute pancreatitis (rather than colitis) is one of the

  11. How does the Redi parameter for mesoscale mixing impact global climate in an Earth System Model?

    NASA Astrophysics Data System (ADS)

    Pradal, Marie-Aude; Gnanadesikan, Anand

    2014-09-01

    A coupled climate model is used to examine the impact of an increase in the mixing due to mesoscale eddies on the global climate system. A sixfold increase in the Redi mixing coefficient ARedi, which is within the admissible range of variation, has the overall effect of warming the global-mean surface air and sea surface temperatures by more than 1°C. Locally, sea surface temperatures increase by up to 7°C in the North Pacific and by up to 4°C in the Southern Ocean, with corresponding impacts on the ice concentration and ice extent in polar regions. However, it is not clear that the changes in heat transport from tropics to poles associated with changing this coefficient are primarily responsible for these changes. We found that the changes in the transport of heat are often much smaller than changes in long-wave trapping and short-wave absorption. Additionally, changes in the advective and diffusive transport of heat toward the poles often oppose each other. However, we note that the poleward transport of salt increases near the surface as ARedi increases. We suggest a causal chain in which enhanced eddy stirring leads to increased high-latitude surface salinity reducing salt stratification and water column stability and enhancing convection, triggering two feedback loops. In one, deeper convection prevents sea ice formation, which decreases albedo, which increases SW absorption, further increasing SST and decreasing sea ice formation. In the other, increased SST and reduced sea ice allow for more water vapor in the atmosphere, trapping long-wave radiation. Destratifying the polar regions is thus a potential way in which changes in ocean circulation might warm the planet.

  12. Does Model Development Ahead of Data Collection Have Merit? A Case for Advancing Non-Local Fluvial Transport Theories

    NASA Astrophysics Data System (ADS)

    Voller, V. R.; Falcini, F.; Foufoula-Georgiou, E.; Ganti, V.; Paola, C.; Hill, K. M.; Swenson, J. B.; Longjas, A.

    2013-12-01

    not always associated with the same sediment flux. The key innovation then is to model the sediment flux at a point in terms of an upstream weighted sum of fluvial slopes or other geomorphological attributes of the system. In the hill-slope context, the downstream flow of information in this non-local formalism is well supported by fundamental observations of the distribution of downstream particle transport distances. However, when the same model is applied in the context of depositional systems it appears to be inconsistent with profiles of depositional surfaces. In particular, the model predicts fluvial profiles with curvature signs opposite to those observed in nature. When a simple mathematical manipulation is made, where the flux at a point is expressed as a downstream weighting of fluvial slopes, however, predictions with the correct form are recovered. At this time, no specific mechanism or clear corroborating data have been identified that would explain this downstream control. Does this mean we should ignore this result or would it be better to use it as a motivation to seek out hypotheses tests that would confirm or invalidate the current suggested models of downstream non-local transport? A series of innovative experiments that address the collection of experimental evidence for downstream control in fluvial transport are described.

  13. Final technical report: Partial support for US participants in the 5th International Marine Biotechnology Conference, Townsville, Australia, Sept 29 - Oct 5, 2000

    SciTech Connect

    Zohar, Yonathan; Hill, R.; Robb, F.

    2001-04-09

    Funding was provided for US participants in the 5th International Marine Biotechnology Conference held in Townsville, Australia from September 29 to October 5, 2000. DOE funds were used for travel awards for six US participants in this conference. DOE funds were successfully used to advance participation of US scientists in the important emerging field of marine biotechnology.

  14. FOREWORD: International Conference on Planetary Boundary Layer and Climate Change

    NASA Astrophysics Data System (ADS)

    Djolov, G.; Esau, I.

    2010-05-01

    One of the greatest achievements of climate science has been the establisment of the concept of climate change on a multitude of time scales. The Earth's complex climate system does not allow a straightforward interpretation of dependences between the external parameter perturbation, internal stochastic system dynamics and the long-term system response. The latter is usually referred to as climate change in a narrow sense (IPCC, 2007). The focused international conference "Planetary Boundary Layers and Climate Change" has addressed only time scales and dynamical aspects of climate change with possible links to the turbulent processes in the Planetary Boundary Layer (PBL). Although limited, the conference topic is by no means singular. One should clearly understand that the PBL is the layer where 99% of biosphere and human activity are concentrated. The PBL is the layer where the energy fluxes, which are followed by changes in cryosphere and other known feedbacks, are maximized. At the same time, the PBL processes are of a naturally small scale. What is the averaged long-term effect of the small-scale processes on the long-term climate dynamics? Can this effect be recognized in existing long-term paleo-climate data records? Can it be modeled? What is the current status of our theoretical understanding of this effect? What is the sensitivity of the climate model projections to the representation of small-scale processes? Are there significant indirect effects, e.g. through transport of chemical components, of the PBL processes on climate? These and other linked questions have been addressed during the conference. The Earth's climate has changed many times during the planet's history, with events ranging from ice ages to long periods of warmth. Historically, natural factors such as the amount of energy released from the Sun, volcanic eruptions and changes in the Earth's orbit have affected the Earth's climate. Beginning late in the 18th century, human activities

  15. The Writing Conference as Performance.

    ERIC Educational Resources Information Center

    Newkirk, Thomas

    1995-01-01

    Provides an overview of the conversational roles taken on by students and teachers during college-level writing conferences. Uses the performative theory of Erving Goffman to analyze these role patterns. Illuminates the specific performative demands presented by writing conferences on both students and teachers. (HB)

  16. SLA at 100: Conference Preview

    ERIC Educational Resources Information Center

    Blumenstein, Lynn

    2009-01-01

    When School Library Association (SLA) convenes its annual conference in Washington, DC, June 14-17, 2009, the association will be celebrating its 100th birthday. This occasion allows for grand gestures--the SLA Salutes! Awards and Leadership Reception will be held in the Library of Congress's Great Hall. The conference also draws upon Washington…

  17. Conference Connections: Rewiring the Circuit

    ERIC Educational Resources Information Center

    Siemens, George; Tittenberger, Peter; Anderson, Terry

    2008-01-01

    Increased openness, two-way dialogue, and blurred distinctions between experts and amateurs have combined with numerous technology tools for dialogue, personal expression, networking, and community formation to "remake" conferences, influencing not only how attendees participate in but also how organizers host conferences today. (Contains 31…

  18. Sixth National Conference on Citizenship.

    ERIC Educational Resources Information Center

    Department of Justice, Washington, DC.

    The document presents proceedings from the sixth in a series of annual national citizenship conferences. Held in Washington, D.C. in 1951, the conference served as a forum where educational, political, business, religious, labor, civic, and communications leaders could explore functions and duties of American citizenship. The theme of the…

  19. XVth World Conference of the International Union for Health Promotion and Education, Makuhari, Japan, 20-25 August 1995. Conference report.

    PubMed

    Westaway, M S

    1995-09-01

    This article briefly highlights information provided by speakers at the World Conference of the International Union for Health Promotion and Education. The conference took place during August 1995, in Makuhari, Japan. One paper focused on health education in Japan, which would not be suitable for health promotion efforts in South Africa. Another paper focused on intersectoral efforts for health, policy, and networking. This paper addressed an issue important for all countries; the need for better communication among people working in health fields and improved outreach. A paper focusing on strengthening community action was presented. South Africa, as well as Japan, must work to involve communities in health service management. The author found that the paper on policy, practice, and research for health promotion and education was relevant to South Africa. Policymakers and practitioners tend to rely on precedence, intuition, personal experience, and political experience. Academic research funding does not support research that is relevant to policymakers and practitioners. The papers on healthy cities research were stimulating and had practical input. The proposed model involved a 3-phase and 14-step process of choosing a topic for an intervention, analyzing the intervention's political environment, and planning the political aspects of intervention. Another model of intersectoral action was spiral shaped and centered problem definition, direction setting, and structuring between networking and interorganizational relations. Four papers from Botswana focused on reproductive health. Other papers focused on teenage pregnancy. PMID:12178482

  20. 10 CFR 2.329 - Prehearing conference.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... place for a conference or conferences before trial. A prehearing conference in a proceeding involving a... proceeding; (10) The setting of a hearing schedule, including any appropriate limitations on the scope...

  1. 10 CFR 2.329 - Prehearing conference.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... place for a conference or conferences before trial. A prehearing conference in a proceeding involving a... proceeding; (10) The setting of a hearing schedule, including any appropriate limitations on the scope...

  2. 77 FR 38306 - GFIRST Conference Stakeholder Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... SECURITY GFIRST Conference Stakeholder Evaluation AGENCY: National Protection and Programs Directorate, DHS... concerning new Information Collection Request--GFIRST Conference Stakeholder Evaluation. DHS previously... Conference Stakeholder Evaluation Forms. There is no reference to the I-9 Form on the GFIRST...

  3. 38 CFR 39.33 - Conferences.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... STATES FOR ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement Projects Grant Requirements and Procedures § 39.33 Conferences. (a) Predesign conference. A predesign conference is required for all Establishment,...

  4. 38 CFR 39.33 - Conferences.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement Projects Grant Requirements and Procedures § 39.33 Conferences. (a) Predesign conference. A predesign conference is required for all Establishment, Expansion, and...

  5. 38 CFR 39.33 - Conferences.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement Projects Grant Requirements and Procedures § 39.33 Conferences. (a) Predesign conference. A predesign conference is required for all Establishment, Expansion, and...

  6. 38 CFR 39.33 - Conferences.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement Projects Grant Requirements and Procedures § 39.33 Conferences. (a) Predesign conference. A predesign conference is required for all Establishment, Expansion, and...

  7. Megagauss X: a conference milestone /

    SciTech Connect

    Fowler, C. M.

    2004-01-01

    The first Megagauss Conference now known as MG I, was held in 1965. Thirty-nine years later, we are now attending MG X. As topical conferences go, this is a fairly long time. For comparison, the first IEEE International Pulsed Power Conference was held in 1976. It seems appropriate in the opening address of this 'Milestone' conference to note some highlights of the earlier MG conferences. Some relatively new research lines in progress will also be noted, as well as the speaker's 'wish list' of projects he would like to see pursued. Mention will be made of the growing number of explosive flux compression facilities around the world, as well as some facilities that no longer exist, but that made significant contributions in their time.

  8. Galileo Space Probe News Conference

    NASA Astrophysics Data System (ADS)

    1996-01-01

    This NASA Kennedy Space Center (KSC) video release presents Part 2 of a press conference regarding the successful entry of the Galileo Space Probe into Jupiter's atmosphere. The press conference panel is comprised of twelve principal investigators and project scientists that oversee the Galileo mission. The press conference question and answer period is continued from Part 1. Atmospheric thermal structure, water abundances, wind profiles, and electricity are among the topics discussed. The question and answer period is followed by a 3 minute presentation in which all of the visuals that are shown during the press conference are reviewed. Parts 1 and 3 of the press conference can be found in document numbers NONP-NASA-VT-2000001073, and NONP-NASA-VT-2000001075.

  9. Aerospace Environmental Technology Conference

    SciTech Connect

    Whitaker, A.F.

    1995-03-01

    The mandated elimination of CFC`s, Halons, TCA, and other ozone depleting chemicals and specific hazardous materials has required changes and new developments in aerospace materials and processes. The aerospace industry has been involved for several years in providing product substitutions, redesigning entire production processes, and developing new materials that minimize or eliminate damage to the environment. These activities emphasize replacement cleaning solvents and their application verifications, compliant coatings including corrosion protection systems, and removal techniques, chemical propulsion effects on the environment, and the initiation of modifications to relevant processing and manufacturing specifications and standards. The Executive Summary of this Conference is published as NASA CP-3297. Separate abstracts have been prepared for some articles from this report.

  10. Proceedings of the second international conference on ground water ecology

    SciTech Connect

    Stanford, J.A.; Valett, H.M.

    1994-12-31

    This conference was held March 27--30, 1994 in Atlanta, Georgia. The purpose of this conference was to provide a forum for state-of-the-art information on groundwater ecosystems. Attention is focused on the following topics: Biogeochemistry; ecology of metazoans; ground water management; microbial ecology; modeling; pollution, restoration and bioremediation; problems in karst systems; and surface and ground water interaction zones. Individual papers are processed separately for inclusion in the appropriate data bases.

  11. 4th International Plant Biomechanics Conference Proceedings (Abstracts)

    SciTech Connect

    Frank W. Telewski; Lothar H. Koehler; Frank W. Ewers

    2003-07-20

    The 4th International Plant Biomechanics Conference facilitated an interdisciplinary exchange between scientists, engineers, and educators addressing the major questions encountered in the field of Plant Biomechanics. Subjects covered by the conference include: Evolution; Ecology; Mechanoreception; Cell Walls; Genetic Modification; Applied Biomechanics of Whole Plants, Plant Products, Fibers & Composites; Fluid Dynamics; Wood & Trees; Fracture Mechanics; Xylem Pressure & Water Transport; Modeling; and Introducing Plant Biomechanics in Secondary School Education.

  12. Tenth Biennial Coherent Laser Radar Technology and Applications Conference

    NASA Technical Reports Server (NTRS)

    Kavaya, Michael J. (Compiler)

    1999-01-01

    The tenth conference on coherent laser radar technology and applications is the latest in a series beginning in 1980 which provides a forum for exchange of information on recent events current status, and future directions of coherent laser radar (or lidar or lader) technology and applications. This conference emphasizes the latest advancement in the coherent laser radar field, including theory, modeling, components, systems, instrumentation, measurements, calibration, data processing techniques, operational uses, and comparisons with other remote sensing technologies.

  13. Personalized cancer care conference.

    PubMed

    Zänker, Kurt S; Mihich, Enrico; Huber, Hans-Peter; Borresen-Dale, Anne-Lise

    2013-01-01

    The Oslo University Hospital (Norway), the K.G. Jebsen Centre for Breast Cancer Research (Norway), The Radiumhospital Foundation (Norway) and the Fritz-Bender-Foundation (Germany) designed under the conference chairmen (E. Mihich, K.S. Zänker, A.L. Borresen-Dale) and advisory committee (A. Borg, Z. Szallasi, O. Kallioniemi, H.P. Huber) a program at the cutting edge of "PERSONALIZED CANCER CARE: Risk prediction, early diagnosis, progression and therapy resistance." The conference was held in Oslo from September 7 to 9, 2012 and the science-based presentations concerned six scientific areas: (1) Genetic profiling of patients, prediction of risk, late side effects; (2) Molecular profiling of tumors and metastases; (3) Tumor-host microenvironment interaction and metabolism; (4) Targeted therapy; (5) Translation and (6) Informed consent, ethical challenges and communication. Two satellite workshops on (i) Ion Ampliseq-a novel tool for large scale mutation detection; and (ii) Multiplex RNA ISH and tissue homogenate assays for cancer biomarker validation were additionally organized. The report concludes that individual risk prediction in carcinogenesis and/or metastatogenesis based on polygenic profiling may be useful for intervention strategies for health care and therapy planning in the future. To detect distinct and overlapping DNA sequence alterations in tumor samples and adjacent normal tissues, including point mutations, small insertions or deletions, copy number changes and chromosomal rearrangements will eventually make it possible to design personalized management plans for individualized patients. However, large individualized datasets need a new approach in bio-information technology to reduce this enormous data dimensionally to simply working hypotheses about health and disease for each individual. PMID:25562519

  14. Personalized Cancer Care Conference

    PubMed Central

    Zänker, Kurt S.; Mihich, Enrico; Huber, Hans-Peter; Borresen-Dale, Anne-Lise

    2013-01-01

    The Oslo University Hospital (Norway), the K.G. Jebsen Centre for Breast Cancer Research (Norway), The Radiumhospital Foundation (Norway) and the Fritz-Bender-Foundation (Germany) designed under the conference chairmen (E. Mihich, K.S. Zänker, A.L. Borresen-Dale) and advisory committee (A. Borg, Z. Szallasi, O. Kallioniemi, H.P. Huber) a program at the cutting edge of “PERSONALIZED CANCER CARE: Risk prediction, early diagnosis, progression and therapy resistance.” The conference was held in Oslo from September 7 to 9, 2012 and the science-based presentations concerned six scientific areas: (1) Genetic profiling of patients, prediction of risk, late side effects; (2) Molecular profiling of tumors and metastases; (3) Tumor-host microenvironment interaction and metabolism; (4) Targeted therapy; (5) Translation and (6) Informed consent, ethical challenges and communication. Two satellite workshops on (i) Ion Ampliseq—a novel tool for large scale mutation detection; and (ii) Multiplex RNA ISH and tissue homogenate assays for cancer biomarker validation were additionally organized. The report concludes that individual risk prediction in carcinogenesis and/or metastatogenesis based on polygenic profiling may be useful for intervention strategies for health care and therapy planning in the future. To detect distinct and overlapping DNA sequence alterations in tumor samples and adjacent normal tissues, including point mutations, small insertions or deletions, copy number changes and chromosomal rearrangements will eventually make it possible to design personalized management plans for individualized patients. However, large individualized datasets need a new approach in bio-information technology to reduce this enormous data dimensionally to simply working hypotheses about health and disease for each individual. PMID:25562519

  15. The European Physical Society Conference on High Energy Physics

    NASA Astrophysics Data System (ADS)

    The 2013 Europhysics conference on High Energy Physics is a biennial conference organized by the High Energy and Particle Physics Division of the European Physical Society since 1971. The conference in this series usually attracts 600-700 participants and is one of the worlds largest conferences in this field. The latest conferences in this series were held in Grenoble, Krakow, Manchester, Lisabon and Aachen. The conference has parallel, plenary and poster sessions as well as an industrial exhibition. The conference is jointly organised by the Royal Institute of Technology, Stockholm University, Chalmers University of Technology, Lund University, Uppsala University, Nordita and the Oskar Klein Centre. Topics covered are: Standard Model and Beyond Electroweak Symmetry Breaking Neutrino Physics Flavour Physics CP Violation and Tests of Fundamental Symmetries QCD and Hadronic Physics Heavy Ions Astroparticle Physics High Energy Astrophysics Cosmology Non-perturbative Field Theory String Theory Detectors and Data Handling Accelerator R&D Future Facilities. Special ECFA session 20 July: Particle Physics after the European strategy update

  16. 76 FR 52667 - International Conference on Harmonisation; Guidance on E2F Development Safety Update Report...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... Japanese Ministry of Health, Labour, and Welfare; the Japanese Pharmaceutical Manufacturers Association.... In the Federal Register of August 5, 2008 (73 FR 45462), FDA published a notice announcing the... current thinking on this topic. It does not create or confer any rights for or on any person and does...

  17. 29 CFR 6.53 - Prehearing conference.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FEDERALLY ASSISTED CONSTRUCTION CONTRACTS AND FEDERAL SERVICE CONTRACTS Substantial Variance and Arm's Length Proceedings § 6.53 Prehearing conference. (a) At the prehearing conference the Administrative...

  18. International Conference on the Cell and Molecular Biology of Chlamydomonas

    SciTech Connect

    Dr. Stephen Miller

    2010-06-10

    The 2010 Conference on the Cell and Molecular Biology of Chlamydomonas was held June 6-10 near Boston, MA, and attracted a record 273 participants, 146 from US labs, 10 from Canada, and the remainder from 18 other countries. The single-celled algal protist Chlamydomonas is a key research organism for many investigators, including those who study photosynthesis, cell motility, adaptation to environmental stresses, the evolution of multicellularity, and the production of biofuels. Chlamydomonas researchers gather every two years at a research conference to exchange methods, develop collaborative efforts, disseminate recent findings, and plan large-scale studies to improve the usefulness of this unique research organism. This conference provides the only opportunity for Chlamydomonas scientists who work on different research problems to meet face to face, and greatly speeds progress in their respective fields. An important function of these Chlamydomonas conferences is to promote and showcase the work of younger scientists, and to attract new investigators into the Chlamydomonas community. DOE award SC0004085 was used to offset the travel and registration costs for 18 young investigators, 9 of whom were women, including one African American. Most of these scientists would not have been able to attend the conference without DOE support. A total of 208 research presentations were made at the meeting, 80 talks (63 presented by students, postdocs, and pre-tenured faculty) and 128 posters. Cell motility and biofuels/metabolism were the best-represented research areas, with a total of 77 presentations. This fact underscores the growing importance of Chlamydomonas as a research and production tool in the rapidly expanding world of biofuels research. A total of 28 talks and posters were presented on the topics of photosynthesis and stress responses, which were among the next best-represented research areas. As at several recent Chlamydomonas meetings, important advances were

  19. Computational Biology Support: RECOMB Conference Series (Conference Support)

    SciTech Connect

    Michael Waterman

    2006-06-15

    This funding was support for student and postdoctoral attendance at the Annual Recomb Conference from 2001 to 2005. The RECOMB Conference series was founded in 1997 to provide a scientific forum for theoretical advances in computational biology and their applications in molecular biology and medicine. The conference series aims at attracting research contributions in all areas of computational molecular biology. Typical, but not exclusive, the topics of interest are: Genomics, Molecular sequence analysis, Recognition of genes and regulatory elements, Molecular evolution, Protein structure, Structural genomics, Gene Expression, Gene Networks, Drug Design, Combinatorial libraries, Computational proteomics, and Structural and functional genomics. The origins of the conference came from the mathematical and computational side of the field, and there remains to be a certain focus on computational advances. However, the effective use of computational techniques to biological innovation is also an important aspect of the conference. The conference had a growing number of attendees, topping 300 in recent years and often exceeding 500. The conference program includes between 30 and 40 contributed papers, that are selected by a international program committee with around 30 experts during a rigorous review process rivaling the editorial procedure for top-rate scientific journals. In previous years papers selection has been made from up to 130--200 submissions from well over a dozen countries. 10-page extended abstracts of the contributed papers are collected in a volume published by ACM Press and Springer, and are available at the conference. Full versions of a selection of the papers are published annually in a special issue of the Journal of Computational Biology devoted to the RECOMB Conference. A further point in the program is a lively poster session. From 120-300 posters have been presented each year at RECOMB 2000. One of the highlights of each RECOMB conference is a

  20. Dose Modeling Evaluations and Technical Support Document For the Authorized Limits Request for the DOE-Owned Property Outside the Limited Area, Paducah Gaseous Diffusion Plant Paducah, Kentucky

    SciTech Connect

    Boerner, A. J.; Maldonado, D. G.; Hansen, Tom

    2012-09-01

    Environmental assessments and remediation activities are being conducted by the U.S. Department of Energy (DOE) at the Paducah Gaseous Diffusion Plant (PGDP), Paducah, Kentucky. The Oak Ridge Institute for Science and Education (ORISE), a DOE prime contractor, was contracted by the DOE Portsmouth/Paducah Project Office (DOE-PPPO) to conduct radiation dose modeling analyses and derive single radionuclide soil guidelines (soil guidelines) in support of the derivation of Authorized Limits (ALs) for 'DOE-Owned Property Outside the Limited Area' ('Property') at the PGDP. The ORISE evaluation specifically included the area identified by DOE restricted area postings (public use access restrictions) and areas licensed by DOE to the West Kentucky Wildlife Management Area (WKWMA). The licensed areas are available without restriction to the general public for a variety of (primarily) recreational uses. Relevant receptors impacting current and reasonably anticipated future use activities were evaluated. In support of soil guideline derivation, a Conceptual Site Model (CSM) was developed. The CSM listed radiation and contamination sources, release mechanisms, transport media, representative exposure pathways from residual radioactivity, and a total of three receptors (under present and future use scenarios). Plausible receptors included a Resident Farmer, Recreational User, and Wildlife Worker. single radionuclide soil guidelines (outputs specified by the software modeling code) were generated for three receptors and thirteen targeted radionuclides. These soil guidelines were based on satisfying the project dose constraints. For comparison, soil guidelines applicable to the basic radiation public dose limit of 100 mrem/yr were generated. Single radionuclide soil guidelines from the most limiting (restrictive) receptor based on a target dose constraint of 25 mrem/yr were then rounded and identified as the derived soil guidelines. An additional evaluation using the derived soil