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Sample records for dominik zak jrg

  1. A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response.

    PubMed

    Jandhyala, Dakshina M; Wong, John; Mantis, Nicholas J; Magun, Bruce E; Leong, John M; Thorpe, Cheleste M

    2016-01-01

    Ricin activates the proinflammatory ribotoxic stress response through the mitogen activated protein 3 kinase (MAP3K) ZAK, resulting in activation of mitogen activated protein kinases (MAPKs) p38 and JNK1/2. We had a novel zak-/- mouse generated to study the role of ZAK signaling in vivo during ricin intoxication. To characterize this murine strain, we intoxicated zak-/- and zak+/+ bone marrow-derived murine macrophages with ricin, measured p38 and JNK1/2 activation by Western blot, and measured zak, c-jun, and cxcl-1 expression by qRT-PCR. To determine whether zak-/- mice differed from wild-type mice in their in vivo response to ricin, we performed oral ricin intoxication experiments with zak+/+ and zak-/- mice, using blinded histopathology scoring of duodenal tissue sections to determine differences in tissue damage. Unlike macrophages derived from zak+/+ mice, those derived from the novel zak-/- strain fail to activate p38 and JNK1/2 and have decreased c-jun and cxcl-1 expression following ricin intoxication. Furthermore, compared with zak+/+ mice, zak-/- mice have decreased duodenal damage following in vivo ricin challenge. zak-/- mice demonstrate a distinct ribotoxic stress-associated phenotype in response to ricin and therefore provide a new animal model for in vivo studies of ZAK signaling. PMID:27598200

  2. A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

    PubMed Central

    Jandhyala, Dakshina M.; Wong, John; Mantis, Nicholas J.; Magun, Bruce E.; Leong, John M.; Thorpe, Cheleste M.

    2016-01-01

    Ricin activates the proinflammatory ribotoxic stress response through the mitogen activated protein 3 kinase (MAP3K) ZAK, resulting in activation of mitogen activated protein kinases (MAPKs) p38 and JNK1/2. We had a novel zak−/− mouse generated to study the role of ZAK signaling in vivo during ricin intoxication. To characterize this murine strain, we intoxicated zak−/− and zak+/+ bone marrow–derived murine macrophages with ricin, measured p38 and JNK1/2 activation by Western blot, and measured zak, c-jun, and cxcl-1 expression by qRT-PCR. To determine whether zak−/− mice differed from wild-type mice in their in vivo response to ricin, we performed oral ricin intoxication experiments with zak+/+ and zak−/− mice, using blinded histopathology scoring of duodenal tissue sections to determine differences in tissue damage. Unlike macrophages derived from zak+/+ mice, those derived from the novel zak−/− strain fail to activate p38 and JNK1/2 and have decreased c-jun and cxcl-1 expression following ricin intoxication. Furthermore, compared with zak+/+ mice, zak−/− mice have decreased duodenal damage following in vivo ricin challenge. zak−/− mice demonstrate a distinct ribotoxic stress–associated phenotype in response to ricin and therefore provide a new animal model for in vivo studies of ZAK signaling. PMID:27598200

  3. Increased ABA sensitivity results in higher seed dormancy in soft white spring wheat cultivar 'Zak'.

    PubMed

    Schramm, Elizabeth C; Nelson, Sven K; Kidwell, Kimberlee K; Steber, Camille M

    2013-03-01

    As a strategy to increase the seed dormancy of soft white wheat, mutants with increased sensitivity to the plant hormone abscisic acid (ABA) were identified in mutagenized grain of soft white spring wheat "Zak". Lack of seed dormancy is correlated with increased susceptibility to preharvest sprouting in wheat, especially those cultivars with white kernels. ABA induces seed dormancy during embryo maturation and inhibits the germination of mature grain. Three mutant lines called Zak ERA8, Zak ERA19A, and Zak ERA19B (Zak ENHANCED RESPONSE to ABA) were recovered based on failure to germinate on 5 μM ABA. All three mutants resulted in increased ABA sensitivity over a wide range of concentrations such that a phenotype can be detected at very low ABA concentrations. Wheat loses sensitivity to ABA inhibition of germination with extended periods of dry after-ripening. All three mutants recovered required more time to after-ripen sufficiently to germinate in the absence of ABA and to lose sensitivity to 5 μM ABA. However, an increase in ABA sensitivity could be detected after as long as 3 years of after-ripening using high ABA concentrations. The Zak ERA8 line showed the strongest phenotype and segregated as a single semi-dominant mutation. This mutation resulted in no obvious decrease in yield and is a good candidate gene for breeding preharvest sprouting tolerance. PMID:23212773

  4. Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK.

    PubMed

    Vin, Harina; Ching, Grace; Ojeda, Sandra S; Adelmann, Charles H; Chitsazzadeh, Vida; Dwyer, David W; Ma, Haiching; Ehrenreiter, Karin; Baccarini, Manuela; Ruggieri, Rosamaria; Curry, Jonathan L; Ciurea, Ana M; Duvic, Madeleine; Busaidy, Naifa L; Tannir, Nizar M; Tsai, Kenneth Y

    2014-01-01

    Sorafenib is U.S. Food and Drug Adminstration-approved for the treatment of renal cell carcinoma and hepatocellular carcinoma and has been combined with numerous other targeted therapies and chemotherapies in the treatment of many cancers. Unfortunately, as with other RAF inhibitors, patients treated with sorafenib have a 5% to 10% rate of developing cutaneous squamous cell carcinoma (cSCC)/keratoacanthomas. Paradoxical activation of extracellular signal-regulated kinase (ERK) in BRAF wild-type cells has been implicated in RAF inhibitor-induced cSCC. Here, we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun-NH(2)-kinase (JNK) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK). Our results implicate suppression of JNK signaling, independent of the ERK pathway, as an additional mechanism of adverse effects of sorafenib. This has broad implications for combination therapies using sorafenib with other modalities that induce apoptosis. PMID:24170769

  5. Registration of Zak ERA8 soft white spring wheat germplasm with enhanced response to ABA and increased seed dormancy

    Technology Transfer Automated Retrieval System (TEKTRAN)

    ZakERA8 is a unique mutant line selected from mutagenized soft white spring 'Zak' that has increased seed dormancy as a result of enhanced responsiveness to the plant hormone abscisic acid (ABA) during germination. This germplasm was developed by USDA-ARS, Pullman, WA in collaboration with Washingt...

  6. Registration of Zak ERA8 Soft White Spring Wheat Germplasm with Enhanced Response to ABA and Increased Seed Dormancy

    PubMed Central

    Martinez, Shantel A.; Schramm, Elizabeth C.; Harris, Tracy J.; Kidwell, Kimberlee K.; Garland-Campbell, Kimberly; Steber, Camille M.

    2014-01-01

    Zak ERA8 (ENHANCED RESPONSE to ABA8) (Reg. No. GP-966, PI 669443) is a unique line derived from soft white spring wheat (Triticum aestivum L.) cultivar Zak that has increased seed dormancy but after-ripens within 10 to 16 wk. The goal in developing this germplasm was to use increased seed dormancy to improve tolerance to preharvest sprouting, a problem that can cause severe economic losses. This germplasm was developed by USDA–ARS, Pullman, WA, in collaboration with Washington State University. Zak ERA8was tested under experimental number 60.1.27.10. The ERA8mutation was generated by chemical mutagenesis followed by selection for the inability to germinate on abscisic acid (ABA) concentrations too low to inhibit wild-type Zak seed germination. The semidominant Zak ERA8 line has been backcrossed twice to wild-type Zak. Following the first backcross, Zak ERA8 showed similar morphological and grain quality traits to the original Zak cultivar. PMID:25580180

  7. ZAK induces cardiomyocyte hypertrophy and brain natriuretic peptide expression via p38/JNK signaling and GATA4/c-Jun transcriptional factor activation.

    PubMed

    Hsieh, You-Liang; Tsai, Ying-Lan; Shibu, Marthandam Asokan; Su, Chia-Chi; Chung, Li-Chin; Pai, Peiying; Kuo, Chia-Hua; Yeh, Yu-Lan; Viswanadha, Vijaya Padma; Huang, Chih-Yang

    2015-07-01

    Cardiomyocyte hypertrophy is an adaptive response of heart to various stress conditions. During the period of stress accumulation, transition from physiological hypertrophy to pathological hypertrophy results in the promotion of heart failure. Our previous studies found that ZAK, a sterile alpha motif and leucine zipper containing kinase, was highly expressed in infarcted human hearts and demonstrated that overexpression of ZAK induced cardiac hypertrophy. This study evaluates, cellular events associated with the expression of two doxycycline (Dox) inducible Tet-on ZAK expression systems, a Tet-on ZAK WT (wild-type), and a Tet-on ZAK DN (mutant, Dominant-negative form) in H9c2 myoblast cells; Tet-on ZAK WT was found to increase cell size and hypertrophic marker BNP in a dose-dependent manner. To ascertain the mechanism of ZAK-mediated hypertrophy, expression analysis with various inhibitors of the related upstream and downstream proteins was performed. Tet-on ZAK WT expression triggered the p38 and JNK pathway and also activated the expression and nuclear translocation of p-GATA4 and p-c-Jun transcription factors, without the involvement of p-ERK or NFATc3. However, Tet-on ZAK DN showed no effect on the p38 and JNK signaling cascade. The results showed that the inhibitors of JNK1/2 and p38 significantly suppressed ZAK-induced BNP expression. The results show the role of ZAK and/or the ZAK downstream events such as JNK and p38 phosphorylation, c-Jun, and GATA-4 nuclear translocation in cardiac hypertrophy. ZAK and/or the ZAK downstream p38, and JNK pathway could therefore be potential targets to ameliorate cardiac hypertrophy symptoms in ZAK-overexpressed patients. PMID:25869677

  8. Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer

    PubMed Central

    Liu, Jinfeng; McCleland, Mark; Stawiski, Eric W.; Gnad, Florian; Mayba, Oleg; Haverty, Peter M.; Durinck, Steffen; Chen, Ying-Jiun; Klijn, Christiaan; Jhunjhunwala, Suchit; Lawrence, Michael; Liu, Hanbin; Wan, Yinan; Chopra, Vivek; Yaylaoglu, Murat B.; Yuan, Wenlin; Ha, Connie; Gilbert, Houston N.; Reeder, Jens; Pau, Gregoire; Stinson, Jeremy; Stern, Howard M.; Manning, Gerard; Wu, Thomas D.; Neve, Richard M.; de Sauvage, Frederic J.; Modrusan, Zora; Seshagiri, Somasekar; Firestein, Ron; Zhang, Zemin

    2014-01-01

    Gastric cancer is the second leading cause of worldwide cancer mortality, yet the underlying genomic alterations remain poorly understood. Here we perform exome and transcriptome sequencing and SNP array assays to characterize 51 primary gastric tumours and 32 cell lines. Meta-analysis of exome data and previously published data sets reveals 24 significantly mutated genes in microsatellite stable (MSS) tumours and 16 in microsatellite instable (MSI) tumours. Over half the patients in our collection could potentially benefit from targeted therapies. We identify 55 splice site mutations accompanied by aberrant splicing products, in addition to mutation-independent differential isoform usage in tumours. ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers. Overexpression of this particular isoform activates multiple cancer-related transcription factor reporters, while depletion of ZAK in gastric cell lines inhibits proliferation. These results reveal the spectrum of genomic and transcriptomic alterations in gastric cancer, and identify isoform-specific oncogenic properties of ZAK. PMID:24807215

  9. Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice

    PubMed Central

    Spielmann, Malte; Kakar, Naseebullah; Tayebi, Naeimeh; Leettola, Catherine; Nürnberg, Gudrun; Sowada, Nadine; Lupiáñez, Darío G.; Harabula, Izabela; Flöttmann, Ricarda; Horn, Denise; Chan, Wing Lee; Wittler, Lars; Yilmaz, Rüstem; Altmüller, Janine; Thiele, Holger; van Bokhoven, Hans; Schwartz, Charles E.; Nürnberg, Peter; Bowie, James U.; Ahmad, Jamil; Kubisch, Christian; Mundlos, Stefan; Borck, Guntram

    2016-01-01

    The CRISPR/Cas technology enables targeted genome editing and the rapid generation of transgenic animal models for the study of human genetic disorders. Here we describe an autosomal recessive human disease in two unrelated families characterized by a split-foot defect, nail abnormalities of the hands, and hearing loss, due to mutations disrupting the SAM domain of the protein kinase ZAK. ZAK is a member of the MAPKKK family with no known role in limb development. We show that Zak is expressed in the developing limbs and that a CRISPR/Cas-mediated knockout of the two Zak isoforms is embryonically lethal in mice. In contrast, a deletion of the SAM domain induces a complex hindlimb defect associated with down-regulation of Trp63, a known split-hand/split-foot malformation disease gene. Our results identify ZAK as a key player in mammalian limb patterning and demonstrate the rapid utility of CRISPR/Cas genome editing to assign causality to human mutations in the mouse in <10 wk. PMID:26755636

  10. Discovery of Buseckite, (Fe,Zn,Mn)S, a New Mineral in Zakłodzie, an Ungrouped Enstatite-Rich Achondrite

    NASA Astrophysics Data System (ADS)

    Ma, C.; Beckett, J. R.; Rossman, G. R.

    2012-03-01

    We report here new mineral buseckite (Fe,Zn,Mn)S with a wurtzite-type hexagonal structure, and consider the origin of this phase and implications through its formation and survival for the evolution of the Zakłodzie meteorite.

  11. The Armadillo Repeat Gene ZAK IXIK Promotes Arabidopsis Early Embryo and Endosperm Development through a Distinctive Gametophytic Maternal Effect[C][W][OA

    PubMed Central

    Ngo, Quy A.; Baroux, Celia; Guthörl, Daniela; Mozerov, Peter; Collinge, Margaret A.; Sundaresan, Venkatesan; Grossniklaus, Ueli

    2012-01-01

    The proper balance of parental genomic contributions to the fertilized embryo and endosperm is essential for their normal growth and development. The characterization of many gametophytic maternal effect (GME) mutants affecting seed development indicates that there are certain classes of genes with a predominant maternal contribution. We present a detailed analysis of the GME mutant zak ixik (zix), which displays delayed and arrested growth at the earliest stages of embryo and endosperm development. ZIX encodes an Armadillo repeat (Arm) protein highly conserved across eukaryotes. Expression studies revealed that ZIX manifests a GME through preferential maternal expression in the early embryo and endosperm. This parent-of-origin–dependent expression is regulated by neither the histone and DNA methylation nor the DNA demethylation pathways known to regulate some other GME mutants. The ZIX protein is localized in the cytoplasm and nucleus of cells in reproductive tissues and actively dividing root zones. The maternal ZIX allele is required for the maternal expression of MINISEED3. Collectively, our results reveal a reproductive function of plant Arm proteins in promoting early seed growth, which is achieved through a distinct GME of ZIX that involves mechanisms for maternal allele-specific expression that are independent of the well-established pathways. PMID:23064319

  12. Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine kinase and potential ZAK inhibitor imatinib

    PubMed Central

    Stone, Samuel M.; Thorpe, Cheleste M.; Ahluwalia, Amrita; Rogers, Arlin B.; Obata, Fumiko; Vozenilek, Aimee; Kolling, Glynis L.; Kane, Anne V.; Magun, Bruce E.; Jandhyala, Dakshina M.

    2012-01-01

    Shiga toxin producing Escherichia coli (STEC) are a major cause of food-borne illness worldwide. However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagic colitis (HC) is lacking. One of the obstacles to understanding the role of Shiga toxins to STEC-mediated intestinal pathology is a deficit in small animal models that perfectly mimic human disease. Infant rabbits have been previously used to study STEC and/or Shiga toxin-mediated intestinal inflammation and diarrhea. We demonstrate using infant rabbits that Shiga toxin-mediated intestinal damage requires A-subunit activity, and like the human colon, that of the infant rabbit expresses the Shiga toxin receptor Gb3. We also demonstrate that Shiga toxin treatment of the infant rabbit results in apoptosis and activation of p38 within colonic tissues. Finally we demonstrate that the infant rabbit model may be used to test candidate therapeutics against Shiga toxin-mediated intestinal damage. While the p38 inhibitor SB203580 and the ZAK inhibitor DHP-2 were ineffective at preventing Shiga toxin-mediated damage to the colon, pretreatment of infant rabbits with the drug imatinib resulted in a decrease of Shiga toxin-mediated heterophil infiltration of the colon. Therefore, we propose that this model may be useful in elucidating mechanisms by which Shiga toxins could contribute to intestinal damage in the human. PMID:23162799

  13. [Sanitation of the health service centre in Warsaw (Samodzielny Zespół Publicznych Zakładów Lecznictwa Otwartego Warszawa-Mokotów). Financial and economic analysis].

    PubMed

    Buczak-Stec, Elzbieta

    2010-01-01

    The aim of the financial and economic analysis, conducted in March 2010, was to identify all significant factors that had a positive influence on the restructuring process in the health service centre (Samodzielny Zespół Publicznych Zakładów Lecznictwa Otwartego Warszawa--Mokotów) in Warsaw. Within the framework of the analysis, financial data form time period 1999-2009 were analyzed. Also the managing director and financial director were interviewed. Taking into consideration research results it can be stated that not a single factor but a collection of the purposeful efforts influenced the improvement of the health service centre condition. Apart from received public help, the most significant factors include: rational restructuring process, managing of personnel development, professionally managed financial department, cooperation between departments, good internal communication and use of modern management techniques. PMID:21473078

  14. Simulation-Assisted Evaluation of Grinding Circuit Flowsheet Design Alternatives: Aghdarreh Gold Ore Processing Plant / Ocena Alternatywnych Schematów Technologicznych Procesu Rozdrabniania W Zakładach Przeróbki Rud Złota W Aghdarreh, Z Wykorzystaniem Metod Symulacji

    NASA Astrophysics Data System (ADS)

    Farzanegan, A.; Ghalaei, A. Ebtedaei

    2015-03-01

    modification. Surowy urobek z kopalni rud złota Aghdarreh musi najpierw zostać poddany rozdrobnieniu, aby zapewnić efektywniejsze uwalnianie cząsteczek złota. W chwili obecnej obiegi rozdrabniania obejmują kruszenie jednostopniowe z wykorzystaniem kruszarek szczękowych oraz kruszenie jednostopniowe z użyciem kruszarek półautomatycznych w obiegu zamkniętym z hydrocyklonem. Odzysk złota odbywa się przy zastosowaniu procesu ługowania, z zastosowaniem metody cyjankowej w szeregu mieszalników. W pracy tej przeprowadzono optymalizację procesu rozdrabniania rud w zakładach przeróbczych Aghdarreh prowadzonego w celu zmniejszenia rozmiarów uzyskiwanych cząsteczek złota (Ps0) z 70 μm do ok. 40 μm poprzez zapewnienie ciągłości procesu, z wykorzystaniem metod modelowania i symulacji. Na podstawie dwóch zestawów próbek z ciągu technologicznego rozdrabniania, rozkłady wielkości cząstek zostały statystycznie zrównoważone z wykorzystaniem oprogramowania NorBal. Pierwszy i drugi zbiór danych otrzymanych na podstawie dwóch zestawów próbek wykorzystany został do kalibracji i walidacji modeli, przed przystąpieniem do właściwych badań symulacyjnych z użyciem oprogramowania MODSIM. Symulacje komputerowe przeprowadzono w celu oceny wydajności dwóch proponowanych ciągów technologicznych. Pierwszy ciąg obejmuje istniejące kruszarki półautomatyczne i nowo proponowaną kruszarkę kulową pracującą w obiegu zamkniętym z hydrocyklonem. Drugi rozważany ciąg stanowi istniejąca kruszarka półautomatyczna, następnie proponowana kruszarka kulowa pracująca w obiegu zamkniętym z istniejącym hydrocyklonem. We wszystkich symulacjach bazowano na modelach SAGT, CYCL i MILL do symulacji pracy kruszarek półautomatycznych, pakietu hydrocyklonu oraz pojedynczych kruszarek. Modele SAGT i MILL oparte są na modelu zrównoważonej populacji w procesie rozdrabniania. Model CYCL opiera się na empirycznym modelu klasyfikacji Plitta

  15. To Make a Male: What Does It Take?

    ERIC Educational Resources Information Center

    Elfer, Jane; Lee, Anthony

    2009-01-01

    This article presents a case study of a year of psychotherapeutic work by a female and male therapist with a 14-year-old boy born with ambiguous genitalia. His mother was also present in the sessions at the request of Zak. We describe the early trauma surrounding Zak's birth and the subsequent desertion of a violent father. We present the…

  16. Biographical sketch: Franz König, MD 1832-1910.

    PubMed

    Brand, Richard A

    2013-04-01

    This biographical sketch on Franz König corresponds to the historic text, The Classic: Ueber freie Körper in den Gelenken [On loose bodies in the joint] (1887), available at DOI 10.1007/s11999-013-2824-y (Translated by Drs. Richard A. Brand and Christian-Dominik Peterlein).

  17. Biography Today: Sports Series. Profiles of People of Interest to Young Readers. Volume 3, 1999.

    ERIC Educational Resources Information Center

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This third volume is part of a series of biographies that profile individuals of interest to young people over the age of 9 years. The entries in this volume include Joe Dumars, basketball; Jim Harbaugh, football; Dominik Hasek, hockey; Michelle Kwan, figure skating; Rebecca Lobo, basketball; Greg Maddux, baseball; Fatuma Roba, marathon running;…

  18. Comparison of growth, acetate production, and acetate inhibition of Escherichia coli strains in batch and fed-batch fermentations.

    PubMed Central

    Luli, G W; Strohl, W R

    1990-01-01

    The growth characteristics and acetate production of several Escherichia coli strains were compared by using shake flasks, batch fermentations, and glucose-feedback-controlled fed-batch fermentations to assess the potential of each strain to grow at high cell densities. Of the E. coli strains tested, including JM105, B, W3110, W3100, HB101, DH1, CSH50, MC1060, JRG1046, and JRG1061, strains JM105 and B were found to have the greatest relative biomass accumulation, strain MC1060 accumulated the highest concentrations of acetic acid, and strain B had the highest growth rates under the conditions tested. In glucose-feedback-controlled fed-batch fermentations, strains B and JM105 produced only 2 g of acetate.liter-1 while accumulating up to 30 g of biomass.liter-1. Under identical conditions, strains HB101 and MC1060 accumulated less than 10 g of biomass.liter-1 and strain MC1060 produced 8 g of acetate.liter-1. The addition of various concentrations of sodium acetate to the growth medium resulted in a logarithmic decrease, with respect to acetate concentration, in the growth rates of E. coli JM105, JM105(pOS4201), and JRG1061. These data indicated that the growth of the E. coli strains was likely to be inhibited by the acetate they produced when grown on media containing glucose. A model for the inhibition of growth of E. coli by acetate was derived from these experiments to explain the inhibition of acetate on E. coli strains at neutral pH. PMID:2187400

  19. Comparison of growth, acetate production, and acetate inhibition of Escherichia coli strains in batch and fed-batch fermentations.

    PubMed

    Luli, G W; Strohl, W R

    1990-04-01

    The growth characteristics and acetate production of several Escherichia coli strains were compared by using shake flasks, batch fermentations, and glucose-feedback-controlled fed-batch fermentations to assess the potential of each strain to grow at high cell densities. Of the E. coli strains tested, including JM105, B, W3110, W3100, HB101, DH1, CSH50, MC1060, JRG1046, and JRG1061, strains JM105 and B were found to have the greatest relative biomass accumulation, strain MC1060 accumulated the highest concentrations of acetic acid, and strain B had the highest growth rates under the conditions tested. In glucose-feedback-controlled fed-batch fermentations, strains B and JM105 produced only 2 g of acetate.liter-1 while accumulating up to 30 g of biomass.liter-1. Under identical conditions, strains HB101 and MC1060 accumulated less than 10 g of biomass.liter-1 and strain MC1060 produced 8 g of acetate.liter-1. The addition of various concentrations of sodium acetate to the growth medium resulted in a logarithmic decrease, with respect to acetate concentration, in the growth rates of E. coli JM105, JM105(pOS4201), and JRG1061. These data indicated that the growth of the E. coli strains was likely to be inhibited by the acetate they produced when grown on media containing glucose. A model for the inhibition of growth of E. coli by acetate was derived from these experiments to explain the inhibition of acetate on E. coli strains at neutral pH. PMID:2187400

  20. Increased ABA sensitivity results in higher seed dormancy in soft white spring wheat cultivar ‘Zak’

    PubMed Central

    Schramm, Elizabeth C.; Nelson, Sven K.; Kidwell, Kimberlee K.

    2014-01-01

    As a strategy to increase the seed dormancy of soft white wheat, mutants with increased sensitivity to the plant hormone abscisic acid (ABA) were identified in mutagenized grain of soft white spring wheat “Zak”. Lack of seed dormancy is correlated with increased susceptibility to preharvest sprouting in wheat, especially those cultivars with white kernels. ABA induces seed dormancy during embryo maturation and inhibits the germination of mature grain. Three mutant lines called Zak ERA8, Zak ERA19A, and Zak ERA19B (Zak ENHANCED RESPONSE to ABA) were recovered based on failure to germinate on 5 µM ABA. All three mutants resulted in increased ABA sensitivity over a wide range of concentrations such that a phenotype can be detected at very low ABA concentrations. Wheat loses sensitivity to ABA inhibition of germination with extended periods of dry after-ripening. All three mutants recovered required more time to after-ripen sufficiently to germinate in the absence of ABA and to lose sensitivity to 5 µM ABA. However, an increase in ABA sensitivity could be detected after as long as 3 years of after-ripening using high ABA concentrations. The Zak ERA8 line showed the strongest phenotype and segregated as a single semi-dominant mutation. This mutation resulted in no obvious decrease in yield and is a good candidate gene for breeding preharvest sprouting tolerance. PMID:23212773

  1. Adaptation algorithms for 2-D feedforward neural networks.

    PubMed

    Kaczorek, T

    1995-01-01

    The generalized weight adaptation algorithms presented by J.G. Kuschewski et al. (1993) and by S.H. Zak and H.J. Sira-Ramirez (1990) are extended for 2-D madaline and 2-D two-layer feedforward neural nets (FNNs).

  2. Response to Rollock

    ERIC Educational Resources Information Center

    Woods, Ruth

    2008-01-01

    This article presents the author's response to Nicola Rollock's critique on the author's paper in which the author has argued that ethnographic data should be more widely used in psychology (Woods 2005, 2007b). Rollock argues that the paper neglects Zak's level of educational achievement, and fails to critically interrogate his teachers' actions…

  3. Response to Woods--When Rewards and Sanctions Fail: A Case Study of a Primary School Rule-Breaker

    ERIC Educational Resources Information Center

    Rollock, Nicola

    2008-01-01

    Explored through a focus on the behaviour and related experiences of a 9 year old Muslim Somalian boy called Zak, Woods offered a fascinating in-depth case study account of the rewards and sanctions systems in place at a culturally and religiously diverse London primary school. Over a period of 18 months, Woods employed a range of methodological…

  4. Discovery and follow-up of 51 Eri b, a directly-imaged Jupiter-like exoplanet and status of the GPIES campaign.

    NASA Astrophysics Data System (ADS)

    Marchis, Franck; Nielsen, Eric L.; Blunt, Sarah; Rameau, Julien; Barman, Travis; De Rosa, Robert J.; Konopacky, Quinn; Marley, Mark S.; Marois, Christian; Pueyo, Laurent; Rajan, Abhijith; Wang, Jason J.; Macintosh, Bruce; Graham, James R.

    2015-11-01

    Directly detecting thermal emission from young extrasolar planets allows measurement of their atmospheric composition, gravity and luminosity, which is influenced by their formation mechanism. The Gemini Planet Imager Exoplanet Survey (GPIES) is targeting 600 young, nearby stars using the GPI instrument. The star 51 Eridani (51 Eri) was chosen as an early target for the survey due to its youth and proximity. We discovered a planet orbiting the ~20 Myr-old beta Pic moving group member star 51 Eridani at a projected separation of 13 astronomical units (Macintosh et al. Science, 2015). Near-infrared observations show a spectrum with strong methane and water vapor absorption. Modeling of the spectra and photometry yields a luminosity of L/L⦿=1.6-4.0 × 10-6 and an effective temperature of 600-750 K. For this age and luminosity, “hot-start” formation models indicate a mass twice that of Jupiter. This planet also has a sufficiently low luminosity to be the first directly imaged exoplanet to be consistent with the 'cold-start' core accretion process that may have formed Jupiter.Follow-up observations scheduled in Fall 2015 will allow us to constrain the orbit of this exoplanet and derive more information on its atmosphere. These new data, and additional interesting targets, will be presented and discussed.Supported by grants from the National Science Foundation AST-1411868 (BM, KF, JP, AR), AST-0909188 and 1313718 (JRG, PK, RDR, JW), AST-1313718 (MPF and GD) and AST-1405505. Supported by grants from NASA NNX14AJ80G (BM, FM, EN, MP), NNH15AZ591 (DS, MM), NNX15AD95G (JRG, PK), NNX11AD21G (JRG, PK) and NNH11ZDA001N (SM, RP). JR, RD and DL acknowledge support from the Fonds de recherche du Quebec. Portions of this work were performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  5. Cosmic Radiation Fields: Sources in the early Universe

    NASA Astrophysics Data System (ADS)

    Raue, Martin; Kneiske, Tanja; Horns, Dieter; Elsaesser, Dominik; Hauschildt, Peter

    The workshop "Cosmic Radiation Fields - Sources in the Early Universe" (CRF 2010) focuses on the connection between the extragalactic infrared background and sources in the early universe, in particular stars powered by dark matter burning (Dark Stars; DS). The workshop covers the following topics: the cosmic infrared background, formation of early stars, dark stars, effect of dark matter in the early universe, dark matter halos, primordial star formation rate, and reionization. Further information can be found on the conference webpage: http://www.desy.de/crf2010/. Organizing committee: Tanja Kneiske, Martin Raue, Dominik Elsaesser, Alexander Gewering-Peine, Peter Hausschildt, Dieter Horns, and Andreas Maurer.

  6. Lagrangian Modeling of the Atmosphere

    NASA Astrophysics Data System (ADS)

    Schultz, Colin

    2013-08-01

    Like watching a balloon borne by the breeze, a Lagrangian model tracks a parcel of air as it flows through the atmosphere. Whether running forward or backward in time, Lagrangian models offer a powerful tool for tracking and understanding the fates, or origins, of atmospheric flows. In the AGU monograph Lagrangian Modeling of the Atmosphere, editors John Lin, Dominik Brunner, Christoph Gerbig, Andreas Stohl, Ashok Luhar, and Peter Webley explore the nuances of the modeling technique. In this interview Eos talks to Lin about the growing importance of Lagrangian modeling as the world settles on climate change mitigation strategies, the societal value of operational modeling, and how recent advances are making it possible to run these complex calculations at home.

  7. Offshore Wind Farms in the North Sea: Is there an effect on the zooplankton community?

    NASA Astrophysics Data System (ADS)

    Auch, Dominik; Dudeck, Tim; Callies, Ulrich; Riethmüller, Rolf; Hufnagl, Marc; Eckhardt, André; Ove Möller, Klas; Haas, Bianca; Spreitzenbarth, Stefan; van Beusekom, Justus; Walter, Bettina; Temming, Axel; Möllmann, Christian; Floeter, Jens

    2016-04-01

    The climate conference in Paris 2015 has resulted in ambitious goals to mitigate the extent of global climate warming within this century. In Germany, the expansion of renewable energy sources is without any alternative to match the own aims of greenhouse gas reductions. Therefore, in the German EEZ of the North Sea around 10 offshore wind farms (OWFs) are already working and more are currently planned or already under construction. At this already substantial level of offshore wind energy production little is known about the effects of OWFs on the pelagic ecosystem. Earlier investigations have shown an increase of benthic organisms settling on hard substrates provided by the power plant foundations. However, the effects of offshore power plants on lower trophic level organisms within the water column are poorly understood. Thus, we investigated the abundance and distribution of zooplankton within and around OWFs. The analysis was based on optical data derived from a Video Plankton Recorder (VPR). The VPR was mounted on a TRIAXUS system including a suite of different sensors, hence allowing to combine zooplankton information with ambient hydrographic parameters. The combination of the VPR and the TRIAXUS system enabled us to analyse continuous zooplankton and hydrographic data with a high spatial resolution. In this study, we present results of transects through the OWFs Global Tech I, BARD Offshore 1, and Alpha Ventus. The analysis exhibits distinct pattern in the spatial distribution both of physical state variables and of plankton organisms within the vicinity of OWFs, especially of meroplankton, the larval phase of benthic organisms. Keywords: Offshore Wind Farms, Zooplankton, TRIAXUS, Video Plankton Recorder, Meroplankton Corresponding author: Dominik Auch, Institute for Hydrobiology and Fisheries Science, University of Hamburg, Olbersweg 24, 22767 Hamburg, Germany; auch.dominik@web.de

  8. Topological surface plasmons in superlattices with changing sign of the average permittivity.

    PubMed

    Deng, Hanying; Chen, Xianfeng; Panoiu, Nicolae C; Ye, Fangwei

    2016-09-15

    We address the topological properties of one-dimensional plasmonic superlattices composed of alternating metallic and dielectric layers. We reveal that the Zak phase of such plasmonic lattices is determined by the sign of the spatial average of their permittivity, ε¯, and as such the topology and their associated interfacial (edge) states are extremely robust against structural disorder. Our study shows that the topologically protected interfacial modes occurring at the interface between two plasmonic lattices with opposite signs of ε¯ can be viewed as the generalization of the conventional surface plasmon polaritons existing at metallic-dielectric interfaces. PMID:27628377

  9. BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling

    PubMed Central

    Vin, Harina; Ojeda, Sandra S; Ching, Grace; Leung, Marco L; Chitsazzadeh, Vida; Dwyer, David W; Adelmann, Charles H; Restrepo, Monica; Richards, Kristen N; Stewart, Larissa R; Du, Lili; Ferguson, Scarlett B; Chakravarti, Deepavali; Ehrenreiter, Karin; Baccarini, Manuela; Ruggieri, Rosamaria; Curry, Jonathan L; Kim, Kevin B; Ciurea, Ana M; Duvic, Madeleine; Prieto, Victor G; Ullrich, Stephen E; Dalby, Kevin N; Flores, Elsa R; Tsai, Kenneth Y

    2013-01-01

    Vemurafenib and dabrafenib selectively inhibit the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) kinase, resulting in high response rates and increased survival in melanoma. Approximately 22% of individuals treated with vemurafenib develop cutaneous squamous cell carcinoma (cSCC) during therapy. The prevailing explanation for this is drug-induced paradoxical ERK activation, resulting in hyperproliferation. Here we show an unexpected and novel effect of vemurafenib/PLX4720 in suppressing apoptosis through the inhibition of multiple off-target kinases upstream of c-Jun N-terminal kinase (JNK), principally ZAK. JNK signaling is suppressed in multiple contexts, including in cSCC of vemurafenib-treated patients, as well as in mice. Expression of a mutant ZAK that cannot be inhibited reverses the suppression of JNK activation and apoptosis. Our results implicate suppression of JNK-dependent apoptosis as a significant, independent mechanism that cooperates with paradoxical ERK activation to induce cSCC, suggesting broad implications for understanding toxicities associated with BRAF inhibitors and for their use in combination therapies. DOI: http://dx.doi.org/10.7554/eLife.00969.001 PMID:24192036

  10. Geometric ``charge'' pumping with a Bose-Einstein condensate

    NASA Astrophysics Data System (ADS)

    Spielman, Ian

    We realized a quantum ''charge'' pump for a Bose-Einstein condensate (BEC) in a novel bipartite magnetic lattice, whose bands are characterized by non-trivial topological invariants: the Zak phases. For each band, the Zak phase is determined by that band's integrated Berry curvature, a geometric quantity defined at each crystal momentum. We probed this Berry curvature in a charge pump experiment, by periodically and adiabatically driving the system. Unlike topological charge pumps in filled bands that yield quantized pumping, our BEC occupied just a single crystal momentum state allowing us to access its band's local geometry. Like topological charge pumps, for each pump cycle we observed an overall displacement (here, not quantized) and a temporal modulation of the atomic wavepacket's position in each unit cell, i.e., the polarization. Our magnetic lattice enabled us to observe this modulation by measuring the BEC's magnetization. While our periodic drive shifted the lattice potential by one unit cell per cycle, the displacement of the BEC, solely determined by the underlying Berry curvature, was always less than the lattice's displacement.

  11. Direct Measurement of Topological Phases in Discrete-Time Quantum Walks - Experiment

    NASA Astrophysics Data System (ADS)

    Flurin, Emmanuel; Ramasesh, Vinay V.; Hacohen Gourgy, Shay; Yao, Norman Y.; Siddiqi, Irfan

    We perform quantum walks in a cavity QED architecture. Here a transmon qubit plays the role of the quantum coin, while a set of coherent states in an electromagnetic cavity forms the walker's lattice. The strong dispersive coupling between the transmon and cavity naturally implements coin-dependent translations of the walker state. The walk is performed by applying qubit rotations at equally spaced intervals; interestingly, such systems simulate dynamics under effective lattice Hamiltonians which feature strong spin-orbit coupling, leading to non-trivial band topology. By adding an additional step-dependent coin operator, we perform the first direct measurement of a quantum walk Zak phase, delineating between topologically trivial and non-trivial walks. The geometric phase is detected by implementing the quantum walk with the initial state of the walker in a superposition of a coherent state and the vacuum state, which does not partake in the walk. The Zak phase acquired by the walker thus leaves an imprint in the interference fringes of the resulting Schrodinger cat state. We observe these fringes by directly measuring the cavity Wigner function. This research is supported by the ARO.

  12. Distribution of 7Be, 210Pb and 137Cs in watersheds of different scales in the Seine River basin: inventories and residence times.

    PubMed

    Le Cloarec, Marie-Françoise; Bonté, Philippe; Lefèvre, Irène; Mouchel, Jean-Marie; Colbert, Steven

    2007-04-01

    The activity of environmental radionuclides ((7)Be, (210)Pb and (137)Cs) was monitored in nested catchments, inside the Seine River basin. Suspended matter data was collected at 8 different watersheds, ranging from order 1 to order 7, and ranging in size over 4 orders of magnitude. Suspended matter was analyzed for (210)Pb, (137)Cs and (7)Be, and used to calculate the flux of sediments out of each watershed. Monthly atmospheric flux data of (210)Pb and (7)Be was analyzed to assess the input flux of each into the watersheds, taking into account the rainfall during sampling periods. Taking advantage of the different half-lives of (7)Be (53 days) and (210)Pb (22 years), a two-box model was built for each of the catchments following a methodology previously developed by Dominik et al. [Dominik J, Burrus D, Vernet JP. Transport of the environmental radionuclides in alpine watershed. Earth Planet Sci Letters 1987; 84: 165-180.]. The model divides the watershed into a soil box and a rapid reservoir and provides insight into the removal rate of suspended matter from the surrounding watershed. The model enables the assessment of the surface area and the residence time of slow and rapid reservoirs to describe the fate of contaminants of atmospheric origin inside the river basin. The model was improved by considering the dissolved fraction in the total flux and adding the (137)Cs inventory as an additional constraint. The effects of these changes are discussed. Residence times in the soil box, characterized by low transport velocity, range between 4800 years at Melarchez (order 1) to about 30000 years at Andresy and Poses (order 7). They remain constant in each watershed over a large range of variation of atmospheric fluxes of (7)Be and (210)Pb during the whole study, but are sensitive to SM variations. The residence time in the rapid box, which includes the surface of the river and immediate surroundings, is less than one year, while its surface area is in the range 0.6% to

  13. Interferometric approach to measuring band topology in 2D optical lattices.

    PubMed

    Abanin, Dmitry A; Kitagawa, Takuya; Bloch, Immanuel; Demler, Eugene

    2013-04-19

    Recently, optical lattices with nonzero Berry's phases of Bloch bands have been realized. New approaches for measuring Berry's phases and topological properties of bands with experimental tools appropriate for ultracold atoms need to be developed. In this Letter, we propose an interferometric method for measuring Berry's phases of two-dimensional Bloch bands. The key idea is to use a combination of Ramsey interference and Bloch oscillations to measure Zak phases, i.e., Berry's phases for closed trajectories corresponding to reciprocal lattice vectors. We demonstrate that this technique can be used to measure the Berry curvature of Bloch bands, the π Berry's phase of Dirac points, and the first Chern number of topological bands. We discuss several experimentally feasible realizations of this technique, which make it robust against low-frequency magnetic noise.

  14. Topological Optical Waveguiding in Silicon and the Transition between Topological and Trivial Defect States.

    PubMed

    Blanco-Redondo, Andrea; Andonegui, Imanol; Collins, Matthew J; Harari, Gal; Lumer, Yaakov; Rechtsman, Mikael C; Eggleton, Benjamin J; Segev, Mordechai

    2016-04-22

    One-dimensional models with topological band structures represent a simple and versatile platform to demonstrate novel topological concepts. Here we experimentally study topologically protected states in silicon at the interface between two dimer chains with different Zak phases. Furthermore, we propose and demonstrate that, in a system where topological and trivial defect modes coexist, we can probe them independently. Tuning the configuration of the interface, we observe the transition between a single topological defect and a compound trivial defect state. These results provide a new paradigm for topologically protected waveguiding in a complementary metal-oxide-semiconductor compatible platform and highlight the novel concept of isolating topological and trivial defect modes in the same system that can have important implications in topological physics.

  15. Statistical mechanics approach to the electric polarization and dielectric constant of band insulators

    NASA Astrophysics Data System (ADS)

    Combes, Frédéric; Trescher, Maximilian; Piéchon, Frédéric; Fuchs, Jean-Noël

    2016-10-01

    We develop a theory for the analytic computation of the free energy of band insulators in the presence of a uniform and constant electric field. The two key ingredients are a perturbation-like expression of the Wannier-Stark energy spectrum of electrons and a modified statistical mechanics approach involving a local chemical potential in order to deal with the unbounded spectrum and impose the physically relevant electronic filling. At first order in the field, we recover the result of King-Smith, Vanderbilt, and Resta for the electric polarization in terms of a Zak phase—albeit at finite temperature—and, at second order, deduce a general formula for the electric susceptibility, or equivalently for the dielectric constant. Advantages of our method are the validity of the formalism both at zero and finite temperature and the easy computation of higher order derivatives of the free energy. We verify our findings on two different one-dimensional tight-binding models.

  16. Fuzzy model-based observers for fault detection in CSTR.

    PubMed

    Ballesteros-Moncada, Hazael; Herrera-López, Enrique J; Anzurez-Marín, Juan

    2015-11-01

    Under the vast variety of fuzzy model-based observers reported in the literature, what would be the properone to be used for fault detection in a class of chemical reactor? In this study four fuzzy model-based observers for sensor fault detection of a Continuous Stirred Tank Reactor were designed and compared. The designs include (i) a Luenberger fuzzy observer, (ii) a Luenberger fuzzy observer with sliding modes, (iii) a Walcott-Zak fuzzy observer, and (iv) an Utkin fuzzy observer. A negative, an oscillating fault signal, and a bounded random noise signal with a maximum value of ±0.4 were used to evaluate and compare the performance of the fuzzy observers. The Utkin fuzzy observer showed the best performance under the tested conditions.

  17. Topological interface states in multiscale spoof-insulator-spoof waveguides.

    PubMed

    Meng, Yan; Xiang, Hong; Zhang, Ruo-Yang; Wu, Xiaoxiao; Han, Dezhuan; Chan, C T; Wen, Weijia

    2016-08-15

    The spoof-insulator-spoof (SIS) structure can serve as a waveguide for spoof surface plasmon polaritons (spoof SPPs). If a periodic geometry modulation in the wavelength scale is introduced to the SIS waveguide, this multiscale SIS (MSIS) waveguide possesses band gaps for spoof SPPs analogous to the band gaps in a photonic crystal. Inspired by the topological interface states found in photonic crystals, we construct an interface by connecting two MSIS waveguides with different topological properties (inverted Zak phases of bulk bands). The topological interface states in the MSIS waveguides are observed experimentally. The measured decay lengths of the interface states agree excellently with the numerical results. These localized interface states may find potential applications in miniaturized microwave devices. PMID:27519066

  18. Unparticle example in 2D.

    PubMed

    Georgi, Howard; Kats, Yevgeny

    2008-09-26

    We discuss what can be learned about unparticle physics by studying simple quantum field theories in one space and one time dimension. We argue that the exactly soluble 2D theory of a massless fermion coupled to a massive vector boson, the Sommerfield model, is an interesting analog of a Banks-Zaks model, approaching a free theory at high energies and a scale-invariant theory with nontrivial anomalous dimensions at low energies. We construct a toy standard model coupling to the fermions in the Sommerfield model and study how the transition from unparticle behavior at low energies to free particle behavior at high energies manifests itself in interactions with the toy standard model particles.

  19. Fuzzy model-based observers for fault detection in CSTR.

    PubMed

    Ballesteros-Moncada, Hazael; Herrera-López, Enrique J; Anzurez-Marín, Juan

    2015-11-01

    Under the vast variety of fuzzy model-based observers reported in the literature, what would be the properone to be used for fault detection in a class of chemical reactor? In this study four fuzzy model-based observers for sensor fault detection of a Continuous Stirred Tank Reactor were designed and compared. The designs include (i) a Luenberger fuzzy observer, (ii) a Luenberger fuzzy observer with sliding modes, (iii) a Walcott-Zak fuzzy observer, and (iv) an Utkin fuzzy observer. A negative, an oscillating fault signal, and a bounded random noise signal with a maximum value of ±0.4 were used to evaluate and compare the performance of the fuzzy observers. The Utkin fuzzy observer showed the best performance under the tested conditions. PMID:26521723

  20. THE PHYSICS OF PROTOPLANETESIMAL DUST AGGLOMERATES. VI. EROSION OF LARGE AGGREGATES AS A SOURCE OF MICROMETER-SIZED PARTICLES

    SciTech Connect

    Schraepler, Rainer; Blum, Juergen

    2011-06-20

    Observed protoplanetary disks consist of a large amount of micrometer-sized particles. Dullemond and Dominik pointed out for the first time the difficulty in explaining the strong mid-infrared excess of classical T Tauri stars without any dust-retention mechanisms. Because high relative velocities in between micrometer-sized and macroscopic particles exist in protoplanetary disks, we present experimental results on the erosion of macroscopic agglomerates consisting of micrometer-sized spherical particles via the impact of micrometer-sized particles. We find that after an initial phase, in which an impacting particle erodes up to 10 particles of an agglomerate, the impacting particles compress the agglomerate's surface, which partly passivates the agglomerates against erosion. Due to this effect, the erosion halts for impact velocities up to {approx}30 m s{sup -1} within our error bars. For higher velocities, the erosion is reduced by an order of magnitude. This outcome is explained and confirmed by a numerical model. In a next step, we build an analytical disk model and implement the experimentally found erosive effect. The model shows that erosion is a strong source of micrometer-sized particles in a protoplanetary disk. Finally, we use the stationary solution of this model to explain the amount of micrometer-sized particles in the observational infrared data of Furlan et al.

  1. Planet Formation

    NASA Astrophysics Data System (ADS)

    Klahr, Hubert; Brandner, Wolfgang

    2011-02-01

    1. Historical notes on planet formation Bodenheimer; 2. The formation and evolution of planetary systems Bouwman et al.; 3. Destruction of protoplanetary disks by photoevaporation Richling, Hollenbach and Yorke; 4. Turbulence in protoplanetary accretion disks Klahr, Rozyczka, Dziourkevitch, Wunsch and Johansen; 5. The origin of solids in the early solar system Trieloff and Palme; 6. Experiments on planetesimal formation Wurm and Blum; 7. Dust coagulation in protoplanetary disks Henning, Dullemond, Wolf and Dominik; 8. The accretion of giant planet cores Thommes and Duncan; 9. Planetary transits: direct vision of extrasolar planets Lecavelier des Etangs and Vidal-Madjar; 10. The core accretion - gas capture model Hubickyj; 11. Properties of exoplanets Marcy, Fischer, Butler and Vogt; 12. Giant planet formation: theories meet observations Boss; 13. From hot Jupiters to hot Neptures … and below Lovis, Mayor and Udry; 14. Disk-planet interaction and migration Masset and Kley; 15. The Brown Dwarf - planet relation Bate; 16. From astronomy to astrobiology Brandner; 17. Overview and prospective Lin.

  2. Herbig stars' near-infrared excess: An origin in the protostellar disk's magnetically supported atmosphere

    SciTech Connect

    Turner, N. J.; Benisty, M.; Dullemond, C. P.; Hirose, S.

    2014-01-01

    Young stars with masses 2-8 times solar, the Herbig Ae and Be stars, often show a near-infrared excess too large to explain with a hydrostatically supported circumstellar disk of gas and dust. At the same time, the accretion flow carrying the circumstellar gas to the star is thought to be driven by magnetorotational turbulence, which, according to numerical MHD modeling, yields an extended low-density atmosphere supported by the magnetic fields. We demonstrate that the base of the atmosphere can be optically thick to the starlight and that the parts lying near 1 AU are tall enough to double the fraction of the stellar luminosity reprocessed into the near-infrared. We generate synthetic spectral energy distributions (SEDs) using Monte Carlo radiative transfer calculations with opacities for submicron silicate and carbonaceous grains. The synthetic SEDs closely follow the median Herbig SED constructed recently by Mulders and Dominik and, in particular, match the large near-infrared flux, provided the grains have a mass fraction close to interstellar near the disk's inner rim.

  3. The Formation Of The First Solids In The Solar System: An Investigation Of CAI Diversity

    NASA Astrophysics Data System (ADS)

    Taillifet, Esther; Baillié, K.; Charnoz, S.; Aléon, J.

    2012-10-01

    Chondritic meteorites are primitive bodies and therefore an important source of information on the first moments of planets formation. Chondrites contain several materials especially calcium and aluminum rich inclusions (CAIs), known to be the oldest objects of the solar system (4.567 Gyr - Amelin et al., 2002; Connelly et al., 2008) and thus the first solids to be formed. CAIs appear in various textures, sizes and compositions in chondrites. Though, all of them should have formed at high temperature (1300-1800 K) in the same region of the solar nebula by condensation from the gas (e.g. Grossman, 1972; Yoneda & Grossman, 1995; Petaev & Wood, 1998; Ebel & Grossman 2000). To answer this problem we study the CAI formation within the solar nebula using numerical simulations. For this work we developed a self consistent thermodynamical model of the solar nebula (see associated talk from Baillié et. al ) based on previous works (Calvet et. al, 1991; Hueso & Guillot, 2005; Dullemond, Dominik and Natta, 2001). Using this model, we simulate the young system with Lagrangian Implicit Disk Transport code (LIDT - Charnoz et. al, 2010). We will focus on the very first instants of the CAIs within the few years following their condensation. We will report our first results in terms of thermal history and investigate if turbulence-driven transport may explain the CAI diversity.

  4. Characteristics of dune-paleosol-sequences in Fuerteventura. - What should be questioned?

    NASA Astrophysics Data System (ADS)

    Faust, Dominik; Willkommen, Tobias; Yanes, Yurena; Richter, David; Zöller, Ludwig

    2013-04-01

    Characteristics of dune-paleosol-sequences in Fuerteventura. - What should be questioned? Dominik Faust, TU Dresden, Germany Tobias Willkommen, TU Dresden, Germany Yurena Yanes, CSIC Granada/Cincinatti, Spain/USA David Richter, TU Dresden, Germany Ludwig Zöller, Uni Bayreuth, Germany The northern part of Fuerteventura is characterized by large dune fields. We investigated dune-paleosol-sequences in four pits to establish a robust stratigraphy and to propose a standard section. An interaction of processes like dune formation, soil formation and redeposition of soils and sand are most important to understand the principles of landscape development in the study area. To our mind a process cycle seem to be important: First climbing-dunes are formed by sand of shelf origin. Then soil formation could have taken place. Soil and/or sand were then eroded and deposited at toe slope position. This material in turn is the source of new sand supply and dune formation. The described cycle may be repeated several times and this ping-pong-process holds on. The results are sections composed of dune layers, paleosols and colluvial material interbedded. Fundamental questions still remain unanswered: Is climate change responsable for changes in process combination (e.g. from dune formation to soil formation)? Or are these features due to divergence phenomenon, where different effects/results (dune and soils) may be linked to similar causes (here: climate)? Assuming that different features (soils and dunes) were formed under one climate, increasing soil forming intensity could be mainly a function of decreasing sand supply. This in turn could be caused by reduced sand production (s. ZECH et al. accepted). However geochemical data and mollusc assemblages point to changing environments in space and even climate modifications in time.

  5. Purification and properties of lysozyme produced by Staphylococcus aureus.

    PubMed

    Hawiger, J

    1968-02-01

    A method based on cold ethyl alcohol fractionation at different pH levels and ionic strengths and on gel filtration on a Sephadex G-200 column was used to concentrate and purify lysozyme from the culture supernatant fluid of Staphylococcus aureus strain 524. The final, nondialyzable product exhibited a 163-fold rise in specific activity over that of the starting material. Staphylococcal lysozyme is a glycosidase which splits N-acetylamino sugars from the susceptible substrate. Staphylococcal lysozyme was shown to be similar to egg white lysozyme in its optimal temperature for reaction, optimal pH, activation by NaCl and Ca(++) ions, inhibition by sodium citrate and ethylenediaminetetraacetate, and inactivation by Cu(++) ions and sodium dodecyl sulfate. It differs from the egg white lysozyme in its temperature susceptibility range (staphylococcal lysozyme is inactivated at 56 C). It acts on whole cells and cell walls of Micrococcus lysodeikticus, murein from S. aureus 524, and cell walls of S. epidermidis Zak. The last substrate was not susceptible to the action of egg white lysozyme in the test system used. The mechanism of action of staphylococcal lysozyme seems to be analogous to that of egg white lysozyme; however, the biological specificity of the two enzymes may be different.

  6. Unparticle self-interactions

    NASA Astrophysics Data System (ADS)

    Georgi, Howard; Kats, Yevgeny

    2010-02-01

    We develop techniques for studying the effects of self-interactions in the conformal sector of an unparticle model. Their physics is encoded in the higher n-point functions of the conformal theory. We study inclusive processes and argue that the inclusive production of unparticle stuff in standard model processes due to the unparticle self-interactions can be decomposed using the conformal partial wave expansion and its generalizations into a sum over contributions from the production of various kinds of unparticle stuff, corresponding to different primary conformal operators. Such processes typically involve the production of unparticle stuff associated with operators other than those to which the standard model couples directly. Thus just as interactions between particles allow scattering processes to produce new particles in the final state, so unparticle self-interactions cause the production of various kinds of unparticle stuff. We discuss both inclusive and exclusive methods for computing these processes. The resulting picture, we believe, is a step towards understanding what unparticle stuff “looks like” because it is quite analogous to way we describe the production and scattering of ordinary particles in quantum field theory, with the primary conformal operators playing the role of particles and the coefficients in the conformal partial wave expansion (and its generalization to include more fields) playing the role of amplitudes. We exemplify our methods in the 2D toy model that we discussed previously in which the Banks-Zaks theory is exactly solvable.

  7. Topological water wave states in a one-dimensional structure

    NASA Astrophysics Data System (ADS)

    Yang, Zhaoju; Gao, Fei; Zhang, Baile

    2016-07-01

    Topological concepts have been introduced into electronic, photonic, and phononic systems, but have not been studied in surface-water-wave systems. Here we study a one-dimensional periodic resonant surface-water-wave system and demonstrate its topological transition. By selecting three different water depths, we can construct different types of water waves - shallow, intermediate and deep water waves. The periodic surface-water-wave system consists of an array of cylindrical water tanks connected with narrow water channels. As the width of connecting channel varies, the band diagram undergoes a topological transition which can be further characterized by Zak phase. This topological transition holds true for shallow, intermediate and deep water waves. However, the interface state at the boundary separating two topologically distinct arrays of water tanks can exhibit different bands for shallow, intermediate and deep water waves. Our work studies for the first time topological properties of water wave systems, and paves the way to potential management of water waves.

  8. Between chaos and petrification: a summary of the Fifth IPA Conference of Training Analysts.

    PubMed

    Wallerstein, R S

    1993-02-01

    The Fifth IPA Conference of Training Analysts was devoted to the problems in the integration of different theoretical and clinical perspectives in the formation of psychoanalysts, the dialectical tensions between rigidity and stultification on the one hand, and a chaotic 'anything goes' on the other. Seven presentations, from the three major geographical regions and representing a range of theoretical perspectives, though drawing upon common and shared clinical and training experiences, were widely divergent in both their descriptions and their prescriptions. The presentations by Janice de Saussure of Geneva, by Charles Kligerman of Chicago, by Marcio de Freitas Giovanetti of São Paulo, Raquel Zak de Goldstein of Buenos Aires, André Green of Paris, José Infante of Chile and André Lussier of Montreal, are arrayed along a spectrum from the most conservative to the most sweepingly radical critique of our organisations and our practices; what is shared by these seven quite disparate presentations from so many ideologically and geographically diverse quarters is a widespread dissatisfaction with so many aspects of, and so many consequences of, the operation or our extant tripartite training structure bequeathed to us by Eitingon and his colleagues almost 75 years ago and hardly changed at all ever since. PMID:8454399

  9. Between chaos and petrification: a summary of the Fifth IPA Conference of Training Analysts.

    PubMed

    Wallerstein, R S

    1993-02-01

    The Fifth IPA Conference of Training Analysts was devoted to the problems in the integration of different theoretical and clinical perspectives in the formation of psychoanalysts, the dialectical tensions between rigidity and stultification on the one hand, and a chaotic 'anything goes' on the other. Seven presentations, from the three major geographical regions and representing a range of theoretical perspectives, though drawing upon common and shared clinical and training experiences, were widely divergent in both their descriptions and their prescriptions. The presentations by Janice de Saussure of Geneva, by Charles Kligerman of Chicago, by Marcio de Freitas Giovanetti of São Paulo, Raquel Zak de Goldstein of Buenos Aires, André Green of Paris, José Infante of Chile and André Lussier of Montreal, are arrayed along a spectrum from the most conservative to the most sweepingly radical critique of our organisations and our practices; what is shared by these seven quite disparate presentations from so many ideologically and geographically diverse quarters is a widespread dissatisfaction with so many aspects of, and so many consequences of, the operation or our extant tripartite training structure bequeathed to us by Eitingon and his colleagues almost 75 years ago and hardly changed at all ever since.

  10. Nature of Pressure-induced Insulating States in Simple Metals

    NASA Astrophysics Data System (ADS)

    Naumov, Ivan; Hemley, Russell

    As experimentally established, all the alkali metals and heavy alkaline earth metals (Ca, Sr and Ba) become progressively less conductive on compression, at least up to some critical limit over a broad pressure range. Of these metals, Li and Na clearly undergo pressure-induced metal-insulator transitions, which may also be called reverse Mott transitions. Here, using group theory arguments and first-principles calculations, we show that such transitions can be understood in terms of band representations introduced by Zak. The valence bands in the insulating states are described by simple and composite band representations constructed from localized Wannier functions centered on points unoccupied by atoms. The character of the Wannier functions is closely related to the degree of s-p(-d) hybridization and reflects multi-center chemical bonding in these insulating states. The conditions under which an insulating state is allowed for structures having an integer number of atoms per primitive unit cell as well as re-entrant (i.e., metal-insulator-metal) transition sequences are detailed, resulting in predictions of semimetallic phases with flat surface states. The general principles developed are tested and applied to the alkali and alkaline earth metals, including elements where high-pressure insulating phases have been identified or reported (e.g., Li, Na, and Ca). This research was supported by EFree, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences under Award DESC0001057.

  11. Bioequivalence study of 500 mg cefuroxime axetil film-coated tablets in healthy volunteers.

    PubMed

    Kaza, Michał; Leś, Andrzej; Serafin-Byczak, Krystyna; Ksycińska, Hanna; Rudzki, Piotr J; Gutkowskpi, Piotr; Drewniak, Tomasz; Gutkowska, Anna; Tarasiuk, Andrzej; Piatkowska-Chabuda, Ewa; Skowrońska-Smolak, Małgorzata; Wilkowska, Ewa

    2012-01-01

    The aim of the study was to investigate the bioavailability of a generic product of 500 mg cefuroxime axetil film-coated tablets (test) as compared to that of a branded product (reference) at the same strength to determine bioequivalence and to apply for regulatory approval. The secondary objective of the study was to evaluate tolerability of both products. A double blinded, randomized, crossover, two-period, single-dose, comparative study was conducted in Caucasian healthy volunteers in fasting conditions. A single oral dose administration of the test or reference product was followed by 7-day wash-out period. The cefuroxime concentration was determined using a validated HPLC-UV method. The results of the single-dose study in healthy volunteers indicated that the film-coated tablets of Tarsime 500 mg manufactured by Tarchomińskie Zakłady Farmaceutyczne Polfa S.A. (test product) are bioequivalent to those of Zinnat manufactured by GlaxoSmithKline Export Ltd. (reference product). Both products were well tolerated.

  12. Purification and Properties of Lysozyme Produced by Staphylococcus aureus

    PubMed Central

    Hawiger, J.

    1968-01-01

    A method based on cold ethyl alcohol fractionation at different pH levels and ionic strengths and on gel filtration on a Sephadex G-200 column was used to concentrate and purify lysozyme from the culture supernatant fluid of Staphylococcus aureus strain 524. The final, nondialyzable product exhibited a 163-fold rise in specific activity over that of the starting material. Staphylococcal lysozyme is a glycosidase which splits N-acetylamino sugars from the susceptible substrate. Staphylococcal lysozyme was shown to be similar to egg white lysozyme in its optimal temperature for reaction, optimal pH, activation by NaCl and Ca++ ions, inhibition by sodium citrate and ethylenediaminetetraacetate, and inactivation by Cu++ ions and sodium dodecyl sulfate. It differs from the egg white lysozyme in its temperature susceptibility range (staphylococcal lysozyme is inactivated at 56 C). It acts on whole cells and cell walls of Micrococcus lysodeikticus, murein from S. aureus 524, and cell walls of S. epidermidis Zak. The last substrate was not susceptible to the action of egg white lysozyme in the test system used. The mechanism of action of staphylococcal lysozyme seems to be analogous to that of egg white lysozyme; however, the biological specificity of the two enzymes may be different. PMID:4966544

  13. Consistent Perturbative Fixed Point Calculations in QCD and Supersymmetric QCD.

    PubMed

    Ryttov, Thomas A

    2016-08-12

    We suggest how to consistently calculate the anomalous dimension γ_{*} of the ψ[over ¯]ψ operator in finite order perturbation theory at an infrared fixed point for asymptotically free theories. If the n+1 loop beta function and n loop anomalous dimension are known, then γ_{*} can be calculated exactly and fully scheme independently in a Banks-Zaks expansion through O(Δ_{f}^{n}), where Δ_{f}=N[over ¯]_{f}-N_{f}, N_{f} is the number of flavors, and N[over ¯]_{f} is the number of flavors above which asymptotic freedom is lost. For a supersymmetric theory, the calculation preserves supersymmetry order by order in Δ_{f}. We then compute γ_{*} through O(Δ_{f}^{2}) for supersymmetric QCD in the dimensional reduction scheme and find that it matches the exact known result. We find that γ_{*} is astonishingly well described in perturbation theory already at the few loops level throughout the entire conformal window. We finally compute γ_{*} through O(Δ_{f}^{3}) for QCD and a variety of other nonsupersymmetric fermionic gauge theories. Small values of γ_{*} are observed for a large range of flavors. PMID:27563948

  14. Topological water wave states in a one-dimensional structure.

    PubMed

    Yang, Zhaoju; Gao, Fei; Zhang, Baile

    2016-01-01

    Topological concepts have been introduced into electronic, photonic, and phononic systems, but have not been studied in surface-water-wave systems. Here we study a one-dimensional periodic resonant surface-water-wave system and demonstrate its topological transition. By selecting three different water depths, we can construct different types of water waves - shallow, intermediate and deep water waves. The periodic surface-water-wave system consists of an array of cylindrical water tanks connected with narrow water channels. As the width of connecting channel varies, the band diagram undergoes a topological transition which can be further characterized by Zak phase. This topological transition holds true for shallow, intermediate and deep water waves. However, the interface state at the boundary separating two topologically distinct arrays of water tanks can exhibit different bands for shallow, intermediate and deep water waves. Our work studies for the first time topological properties of water wave systems, and paves the way to potential management of water waves. PMID:27373982

  15. Exploring arbitrarily high orders of optimized perturbation theory in QCD with nf → 161/2

    NASA Astrophysics Data System (ADS)

    Stevenson, P. M.

    2016-09-01

    Perturbative QCD with nf flavours of massless quarks becomes simple in the hypothetical limit nf → 161/2, where the leading β-function coefficient vanishes. The Banks-Zaks (BZ) expansion in a0 ≡8/321 (161/2 -nf) is straightforward to obtain from perturbative results in MS ‾ or any renormalization scheme (RS) whose nf dependence is 'regular'. However, 'irregular' RS's are perfectly permissible and should ultimately lead to the same BZ results. We show here that the 'optimal' RS determined by the Principle of Minimal Sensitivity does yield the same BZ-expansion results when all orders of perturbation theory are taken into account. The BZ limit provides an arena for exploring optimized perturbation theory at arbitrarily high orders. These explorations are facilitated by a 'master equation' expressing the optimization conditions in the fixed-point limit. We find an intriguing strong/weak coupling duality a →a*2 / a about the fixed point a*.

  16. Topological water wave states in a one-dimensional structure

    PubMed Central

    Yang, Zhaoju; Gao, Fei; Zhang, Baile

    2016-01-01

    Topological concepts have been introduced into electronic, photonic, and phononic systems, but have not been studied in surface-water-wave systems. Here we study a one-dimensional periodic resonant surface-water-wave system and demonstrate its topological transition. By selecting three different water depths, we can construct different types of water waves - shallow, intermediate and deep water waves. The periodic surface-water-wave system consists of an array of cylindrical water tanks connected with narrow water channels. As the width of connecting channel varies, the band diagram undergoes a topological transition which can be further characterized by Zak phase. This topological transition holds true for shallow, intermediate and deep water waves. However, the interface state at the boundary separating two topologically distinct arrays of water tanks can exhibit different bands for shallow, intermediate and deep water waves. Our work studies for the first time topological properties of water wave systems, and paves the way to potential management of water waves. PMID:27373982

  17. [A comparative analysis of occupational risk in industry employees based on concentrations of some elements in teeth and body fluids].

    PubMed

    Poczatek, Michał; Machoy, Zygmunt; Gutowska, Izabela; Chlubek, Dariusz

    2004-01-01

    Work safety and hygiene is a set of basic measures to protect workers from the negative effects of manufacturing processes. So far, numerous procedures for assessment of occupational health risk have been described. We measured the concentrations of some elements in teeth and body fluids of employees working in three different industries with an established production profile: Zakłady Naprawcze Taboru Kolejowego (repairs of rail vehicles), Philips Lighting Poland (production of lighting systems) and Metalplast (build ing furbishing factory). Different technologies were in place at each of these plants. Basing on laboratory analyses, the risk of exposure to chemical substances was evaluated. The study material included 100 extracted teeth, as well as body fluid samples (saliva, urine and blood) collected during routine health checks. Whenever possible, concentrations of the following elements were measured: calcium, magnesium, fluorine, phosphorus in the form of phosphates, potassium, sodium, iron, zinc, copper, cadmium, and lead. Metal elements were measured spectrophotometrically (ASA), fluorine with an ion-selective electrode, and phosphates with a colorimetric method. We found that concentrations of the elements in teeth and body fluids differed depending on the industry. For teeth, statistically significant differences applied to magnesium, phosphates, zinc, sodium, and potassium. In body fluids, statistically significant differences were found for calcium (blood and urine), magnesium (blood, urine and saliva), zinc (blood, urine and saliva), iron, lead and copper (urine). In conclusion, our findings may be helpful for monitoring safety at work in industrial plants. PMID:16871749

  18. Continuum regularization of quantum field theory

    SciTech Connect

    Bern, Z.

    1986-04-01

    Possible nonperturbative continuum regularization schemes for quantum field theory are discussed which are based upon the Langevin equation of Parisi and Wu. Breit, Gupta and Zaks made the first proposal for new gauge invariant nonperturbative regularization. The scheme is based on smearing in the ''fifth-time'' of the Langevin equation. An analysis of their stochastic regularization scheme for the case of scalar electrodynamics with the standard covariant gauge fixing is given. Their scheme is shown to preserve the masslessness of the photon and the tensor structure of the photon vacuum polarization at the one-loop level. Although stochastic regularization is viable in one-loop electrodynamics, two difficulties arise which, in general, ruins the scheme. One problem is that the superficial quadratic divergences force a bottomless action for the noise. Another difficulty is that stochastic regularization by fifth-time smearing is incompatible with Zwanziger's gauge fixing, which is the only known nonperturbaive covariant gauge fixing for nonabelian gauge theories. Finally, a successful covariant derivative scheme is discussed which avoids the difficulties encountered with the earlier stochastic regularization by fifth-time smearing. For QCD the regularized formulation is manifestly Lorentz invariant, gauge invariant, ghost free and finite to all orders. A vanishing gluon mass is explicitly verified at one loop. The method is designed to respect relevant symmetries, and is expected to provide suitable regularization for any theory of interest. Hopefully, the scheme will lend itself to nonperturbative analysis. 44 refs., 16 figs.

  19. Disentangling running coupling and conformal effects in QCD

    SciTech Connect

    Brodsky, S. J.; Gardi, E.; Grunberg, G.; Rathsman, J.

    2001-05-01

    We investigate the relation between a postulated skeleton expansion and the conformal limit of QCD. We begin by developing some consequences of an Abelian-like skeleton expansion, which allows one to disentangle running-coupling effects from the remaining skeleton coefficients. The latter are by construction renormalon free, and hence hopefully better behaved. We consider a simple ansatz for the expansion, where an observable is written as a sum of integrals over the running coupling. We show that in this framework one can set a unique Brodsky-Lepage-Mackenzie (BLM) scale-setting procedure as an approximation to the running-coupling integrals, where the BLM coefficients coincide with the skeleton ones. Alternatively, the running-coupling integrals can be approximated using the effective charge method. We discuss the limitations in disentangling running coupling effects in the absence of a diagrammatic construction of the skeleton expansion. Independently of the assumed skeleton structure we show that BLM coefficients coincide with conformal coefficients defined in the small {beta}{sub 0} (Banks-Zaks) limit where a perturbative infrared fixed point is present. This interpretation of the BLM coefficients should explain their previously observed simplicity and smallness. Numerical examples are critically discussed.

  20. Long-range doublon transfer in a dimer chain induced by topology and ac fields

    PubMed Central

    Bello, M.; Creffield, C. E.; Platero, G.

    2016-01-01

    The controlled transfer of particles from one site of a spatial lattice to another is essential for many tasks in quantum information processing and quantum communication. In this work we study how to induce long-range transfer between the two ends of a dimer chain, by coupling states that are localized just on the chain’s end-points. This has the appealing feature that the transfer occurs only between the end-points – the particle does not pass through the intermediate sites–making the transfer less susceptible to decoherence. We first show how a repulsively bound-pair of fermions, known as a doublon, can be transferred from one end of the chain to the other via topological edge states. We then show how non-topological surface states of the familiar Shockley or Tamm type can be used to produce a similar form of transfer under the action of a periodic driving potential. Finally we show that combining these effects can produce transfer by means of more exotic topological effects, in which the driving field can be used to switch the topological character of the edge states, as measured by the Zak phase. Our results demonstrate how to induce long range transfer of strongly correlated particles by tuning both topology and driving. PMID:26932406

  1. Purification and properties of lysozyme produced by Staphylococcus aureus.

    PubMed

    Hawiger, J

    1968-02-01

    A method based on cold ethyl alcohol fractionation at different pH levels and ionic strengths and on gel filtration on a Sephadex G-200 column was used to concentrate and purify lysozyme from the culture supernatant fluid of Staphylococcus aureus strain 524. The final, nondialyzable product exhibited a 163-fold rise in specific activity over that of the starting material. Staphylococcal lysozyme is a glycosidase which splits N-acetylamino sugars from the susceptible substrate. Staphylococcal lysozyme was shown to be similar to egg white lysozyme in its optimal temperature for reaction, optimal pH, activation by NaCl and Ca(++) ions, inhibition by sodium citrate and ethylenediaminetetraacetate, and inactivation by Cu(++) ions and sodium dodecyl sulfate. It differs from the egg white lysozyme in its temperature susceptibility range (staphylococcal lysozyme is inactivated at 56 C). It acts on whole cells and cell walls of Micrococcus lysodeikticus, murein from S. aureus 524, and cell walls of S. epidermidis Zak. The last substrate was not susceptible to the action of egg white lysozyme in the test system used. The mechanism of action of staphylococcal lysozyme seems to be analogous to that of egg white lysozyme; however, the biological specificity of the two enzymes may be different. PMID:4966544

  2. Consistent Perturbative Fixed Point Calculations in QCD and Supersymmetric QCD

    NASA Astrophysics Data System (ADS)

    Ryttov, Thomas A.

    2016-08-01

    We suggest how to consistently calculate the anomalous dimension γ* of the ψ ¯ ψ operator in finite order perturbation theory at an infrared fixed point for asymptotically free theories. If the n +1 loop beta function and n loop anomalous dimension are known, then γ* can be calculated exactly and fully scheme independently in a Banks-Zaks expansion through O (Δfn) , where Δf=N¯ f-Nf , Nf is the number of flavors, and N¯f is the number of flavors above which asymptotic freedom is lost. For a supersymmetric theory, the calculation preserves supersymmetry order by order in Δf. We then compute γ* through O (Δf2) for supersymmetric QCD in the dimensional reduction scheme and find that it matches the exact known result. We find that γ* is astonishingly well described in perturbation theory already at the few loops level throughout the entire conformal window. We finally compute γ* through O (Δf3) for QCD and a variety of other nonsupersymmetric fermionic gauge theories. Small values of γ* are observed for a large range of flavors.

  3. Long-range doublon transfer in a dimer chain induced by topology and ac fields.

    PubMed

    Bello, M; Creffield, C E; Platero, G

    2016-03-02

    The controlled transfer of particles from one site of a spatial lattice to another is essential for many tasks in quantum information processing and quantum communication. In this work we study how to induce long-range transfer between the two ends of a dimer chain, by coupling states that are localized just on the chain's end-points. This has the appealing feature that the transfer occurs only between the end-points - the particle does not pass through the intermediate sites-making the transfer less susceptible to decoherence. We first show how a repulsively bound-pair of fermions, known as a doublon, can be transferred from one end of the chain to the other via topological edge states. We then show how non-topological surface states of the familiar Shockley or Tamm type can be used to produce a similar form of transfer under the action of a periodic driving potential. Finally we show that combining these effects can produce transfer by means of more exotic topological effects, in which the driving field can be used to switch the topological character of the edge states, as measured by the Zak phase. Our results demonstrate how to induce long range transfer of strongly correlated particles by tuning both topology and driving.

  4. Continuum regularization of quantum field theory

    SciTech Connect

    Bern, Z.

    1986-01-01

    Breit, Gupta, and Zaks made the first proposal for new gauge invariant nonperturbative regularization. The scheme is based on smearing in the fifth-time of the Langevin equation. An analysis of their stochastic regularization scheme for the case of scalar electrodynamics with the standard covariant gauge fixing is given. Their scheme is shown to preserve the masslessness of the photon and the tensor structure of the photon vacuum polarization at the one-loop level. Although stochastic regularization is viable in one-loop electrodynamics, difficulties arise which, in general, ruins the scheme. A successful covariant derivative scheme is discussed which avoids the difficulties encountered with the earlier stochastic regularization by fifth-time smearing. For QCD the regularized formulation is manifestly Lorentz invariant, gauge invariant, ghost free and finite to all orders. A vanishing gluon mass is explicitly verified at one loop. The method is designed to respect relevant symmetries, and is expected to provide suitable regularization for any theory of interest.

  5. Geomorphological indicators of coseismic and extreme-rainfall slope instabilities in alpine settings (New Zealand, China, Taiwan)

    NASA Astrophysics Data System (ADS)

    Raab, Theresa; Leith, Kerry; Krautblatter, Michael

    2016-04-01

    Wenchuan and progressive slope failure in Taiwan in the years following the events. Interestingly, we find that coseismically induced landslides follow normal trends with respect to slope gradient, whereas slope failures during typhoon Morakot preferentially occurred on steeper slopes than during weak typhoons. In the regions of the 2003 and 2007 earthquakes in Fiordland, as well as in the region of the Wenchuan earthquake, landslide orientation does not suggest enhanced susceptibility due to topographic amplification of oblique incoming seismic waves, and may instead reflect the dependence of weathering and soil production on slope aspect. Slope aspect preference is highly variable in Taiwan, and dependent on wind directions during typhoons. While we cannot account for correlations between sensitivity and landslide occurrence during heavy rainfall events, we identify a noticeable increase in landslide occurrence with increasing sensitivity during seismic shaking. Additionally, landslide rates were found to remain elevated for 1 year, 2 years and 5 years, after typhoon Morakot, the 2003 Fiordland earthquake and the 2008 Wenchuan earthquake, respectively. However, further research needs to be carried out on this newly developed technique of identifying and analyzing slope failures using a global treeloss catalogue. Hansen, M.C., Potapov, P.V., Moore, R., Hancher, M., Turubanova, S.A., Tyukavina, A., Thau, D., Stehman, S. V., Goetz, S.J., Loveland, T.R., Kommareddy, A., Egorov, A., Chini, L., Justice, C.O. & Townshend, J.R.G. (2013): High-Resolution Global Maps of 21st-Century Forest Cover Change. - Science, 342: 850-853.

  6. Midplane Ices in the Embedded Phase

    NASA Astrophysics Data System (ADS)

    Drozdovskaya, Maria; Walsh, Catherine; van Dishoeck, Ewine

    2015-08-01

    Icy grains in the midplanes of the youngest protoplanetary disks are the building blocks of protoplanets and protocometary bodies. Our Solar System shows significant chemical diversity. The chemical content is thought to be either inherited from the initial prestellar cloud, out of which our Solar System formed, or formed in-situ during the subsequent evolution of the protoplanetary disk. In this poster, the chemical analysis of midplanes in the context of globally evolving and collapsing star-forming systems will be presented. Previous studies compared various solid species relative to water ice in comets and towards young protostars [e.g., 1, 2, 3]. It remains unclear whether the overlap in abundances is just a coincidence or whether the origins of cometary ices are that of a prestellar cloud. For this work, an axisymmentric 2D semi-analytic collapse model [4], wavelength-dependent radiative transfer calculations with RADMC3D [5] and a comprehensive gas-grain chemical network [6] are used to pin down ice abundances in a midplane. The methanol content of protoplanetary disks will be presented [7], but also that of other main ice components, such as water, carbon monoxide and carbon dioxide [8]. Our models can be used to probe the validity of theories on the origin of chemical complexity and also to access the degree of processing upon inheritance into the forming disk.[1] Öberg K. I., Boogert A. C. A., Pontoppidan K. M., van den Broek S., van Dishoeck E. F., Bottinelli S., Blake G. A., Evans, II N. J., 2011, ApJ, 740, 109[2] Mumma M. J., Charnley S. B., 2011, ARA&A, 49, 471[3] Bockelée-Morvan D. et al., 2000, A&A, 353, 1101[4] Visser R., van Dishoeck E. F., Doty S. D., Dullemond C. P., 2009, A&A, 495, 881[5] Dullemond C. P., Dominik C., 2004, A&A, 417, 159[6] Walsh C., Millar T. J., Nomura H., Herbst E., Widicus Weaver S., Aikawa Y., Laas J. C., Vasyunin A. I., 2014, A&A, 563, A33[7] Drozdovskaya M. N., Walsh C., Visser R., Harsono D., van Dishoeck E. F., 2014

  7. PEGASUS - An Austrian Nanosatellite for QB50

    NASA Astrophysics Data System (ADS)

    Scharlemann, Carsten; Seifert, Bernhard; Kohl, Dominik; Birschitzky, David; Gury, Lionel; Kerschbaum, Franz; Obertscheider, Christof; Ottensamer, Roland; Reissner, Alexander; Riel, Thomas; Sypniewski, Richard; Taraba, Michael; Trausmuth, Robert; Turetschek, Thomas

    2015-04-01

    PEGASUS - An Austrian Nanosatellite for QB50 C. Scharlemann* David Birschitzky* Lionel Gury*, Franz Kerschbaum~, Dominik Kohl#, Christof Obertscheider*, Roland Ottensamer~, Alexander Reissner+, Thomas Riel#, B. Seifert+, Richard Sypniewski*, Michael Taraba?, Robert Trausmuth*, Thomas Turetschek?, …. (*)University of Applied Sciences Wiener Neustadt, Austria (+)FOTEC GmbH, Wiener Neustadt, Austria (+) Spaceteam, TU Wien, Austria (~) University Wien, Wien, Austria The QB50 project is an international project with the goal to send up to 50 Nanosatellites, a.k.a. CubeSat, into the Thermosphere. The scientific goal of this mission is to monitor over a period of up to nine months the prevailing conditions in this rather unknown part of Earth's atmosphere. Each of the 50 nanosatellites will be equipped with one of three possible scientific instruments: (i) a set of Langmuir probes, (ii) atomic oxygen measurement device, (iii) ion/neutral mass spectrometer. All satellites will be launched together and released in a string-of-pearls type fashion. It is predicted that the satellites will drift apart rather rapidly following the release. Therefore, the QB50 missions offers the possibility of a measurement grid in the thermosphere of unprecedented scope and accuracy. One of the satellites, named PEGASUS, is designed and build by a team of Austrian researches and students. PEGASUS will be equipped with the aforementioned Langmuir probes and will provide information about essential properties of the plasma in the thermosphere such as the electrontemperature and -density. In order to ensure the capability to collect and downlink the data over several months, PEGASUS requires about the same types of subsystems as one would find on large-scale satellites. This includes an attitude control system, an on-board computer, telecommunication devices, an electrical power systems allowing to harvest the solar power and either distribute or store it for later use, a thermal control system

  8. A Complex Organic Slushy Bathing Low-Mass Protostars

    NASA Astrophysics Data System (ADS)

    Drozdovskaya, Maria; Walsh, Catherine; Visser, Ruud; Harsono, Daniel; van Dishoeck, Ewine

    2015-08-01

    Complex organic molecules are ubiquitous companions of young forming stars. They were first observed in hot cores surrounding high-mass protostars [e.g., 1], but have since also been detected in the environs of several low-mass counterparts [e.g., 2]. Recent studies have shown that colder envelopes and positions with impinging outflows may also glow with emission from complex organic species [e.g., 3, 4]. For this meeting, I would like to present physicochemical modeling results on the synthesis of complex organics in an envelope-cavity system that is subject to non-thermal processing. This includes wavelength-dependent radiative transfer calculations with RADMC [5] and a comprehensive gas-grain chemical network [6]. The results show that the morphology of such a system delineates three distinct regions: the cavity wall layer with time-dependent and species-variant enhancements; a torus rich in complex organic ices, but not reflected in gas-phase abundances; and the remaining outer envelope abundant in simpler solid and gaseous molecules. Within the adopted paradigm, complex organic molecules are demonstrated to have unique lifetimes and be grouped into early and late species [7]. Key chemical processes for forming and destroying complex organic molecules will be discussed. In addition, the results of adding newly experimentally verified routes [8] into the existing chemical networks will be shown.[1] Blake G. A., Sutton E. C., Masson C. R., Phillips T. G., 1987, ApJ, 315, 621[2] Jørgensen J. K., Favre C., Bisschop S. E., Bourke T. L., van Dishoeck E. F., Schmalzl M., 2012, ApJ, 757, L4[3] Arce H. G., Santiago-García J., Jørgensen J. K., Tafalla M., Bachiller R., 2008, ApJ, 681, L21[4] Öberg K. I., Bottinelli S., Jørgensen J. K., van Dishoeck E. F., 2010, ApJ, 716, 825[5] Dullemond C. P., Dominik C., 2004, A&A, 417, 159[6] Walsh C., Millar T. J., Nomura H., Herbst E., Widicus Weaver S., Aikawa Y., Laas J. C., Vasyunin A. I., 2014, A&A, 563, A33[7] Drozdovskaya

  9. Residence time of suspended particles in the Garonne River (SW France): indications derived from Th-234, Be-7 and Pb-210

    NASA Astrophysics Data System (ADS)

    Schmidt, Sabine; Saari, Hanna-Kaïsa

    2013-04-01

    -temporal variations. Temporal changes in Th-234/Pb-210 and 7Be/210Pb activity ratios (ARs) are complex, depending on river discharge and suspended matter load. To derive sediment ages from the present dataset, two distinct models have been used: 1/ based on radionuclide budget (Dominik et al, 1987, Earth Planet. Sci. Lett. 84 165-180), and 2/ using Be-7/Pb-210 ARs (Matisoff et al, 2005, Earth Surf. Process. Landforms 30 1191-1201). These age estimates will be detailed in order to discuss particulate transport processes in the Garonne river during contrasted hydrological periods (flood and low waters).

  10. The Cost-Optimal Distribution of Wind and Solar Generation Facilities in a Simplified Highly Renewable European Power System

    NASA Astrophysics Data System (ADS)

    Kies, Alexander; von Bremen, Lüder; Schyska, Bruno; Chattopadhyay, Kabitri; Lorenz, Elke; Heinemann, Detlev

    2016-04-01

    . "Investigation of balancing effects in long term renewable energy feed-in with respect to the transmission grid." Advances in Science and Research 12.1 (2015): 91-95, doi:10.5194/asr-12-91-2015 [2] Heide, Dominik, et al. "Reduced storage and balancing needs in a fully renewable European power system with excess wind and solar power generation." Renewable Energy 36.9 (2011): 2515-2523 [3] Rodriguez, R.A.: Weather-driven power transmission in a highly renewable European electricity network, PhD Thesis, Aarhus University, November 2014 [4] Pfluger, B. et al.: Tangible ways towards climate protection in the European Union (EU long-term scenarios 2050), Fraunhofer ISI, Karlsruhe, September 2011

  11. a New Generation Mining Head with Disc Tool of Complex Trajectory / GŁOWICA URABIAJĄCA Nowej Generacji Z NARZĘDZIAMI Dyskowymi O ZŁOŻONEJ Trajektorii

    NASA Astrophysics Data System (ADS)

    Gospodarczyk, Piotr; Kotwica, Krzysztof; Stopka, Grzegorz

    2013-12-01

    łowych warunkach pracy, ulegają przyspieszonemu zużyciu. Wpływa to na prędkość i koszty drążenia tych wyrobisk. W artykule przedstawiono opracowane w Katedrze MGPiT AGH Kraków nowe i innowacyjne rozwiązanie głowicy urabiającej, z narzędziami dyskowymi niesymetrycznymi o złożonej trajektorii, jako alternatywę dla standardowych organów frezujących. Opisano zalety zastosowanej metody urabiania z wykorzystaniem tzw. tylnego podcinaniaoraz zasadę budowy i pracy zaproponowanego rozwiązania przedmiotowej głowicy. Dla opracowania konstrukcji prototypowego egzemplarza tej głowicy koniecznym było określenie, na podstawie badań laboratoryjnych, założeń i wytycznych. Przedstawiono konstrukcję opracowanego specjalnego stanowiska laboratoryjnego do badania narzędzi dyskowych o złożonej trajektorii, założoną metodykę badawczą, przebieg badań oraz uzyskane wyniki. Analiza tych wyników umożliwiła określenie wyżej wymienionych założeń i wytycznych dla konstrukcji głowicy prototypowej. Na ich podstawie opracowano, we współpracy z Zakładami REMAG S.A. w Katowicach, projekt techniczny nowego rozwiązania głowicy, dostosowanej do zabudowy na ramieniu średniego kombajnu chodnikowego KR 150. Wykonany egzemplarz głowicy został poddany próbom na stanowisku badawczym na poligonie Zakładów REMAG i uzyskał pozytywne wyniki badań wstępnych.

  12. PREFACE: XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP) (Group30)

    NASA Astrophysics Data System (ADS)

    Brackx, Fred; De Schepper, Hennie; Van der Jeugt, Joris

    2015-04-01

    participants at the Group30 colloquium from 46 different countries. This high number of participants makes the 30th edition of ICGTMP one of the most successful meetings of the series. We were particularly happy with the attendance of 32 students and many young postdocs: this is promising for the future of the research field and of the colloquium series. The attraction of young scientists was promoted by a reduced participation fee, the availability of cheap accommodation in the University Student Guest House, grants from a US-NSF project and grants from the Organising Committee supporting participants from countries with limited financial resources. The colloquium brought together international top researchers, with a variety of different backgrounds but with "group theoretical or algebraic methods" as common ground. The selection of plenary speakers and topics was made by the Organizing Committee, following the suggestions of the International Advisory Committee (consisting of prominent scientists in their domain), and ensuring the diversity of the subjects treated. There were 11 plenary talks, given as well by distinguished world experts as by young rising stars: Matthias Christandl, Alberto De Sole, Rui Loja Fernandes, François Gay-Balmaz, Gitta Kutyniok, Amiram Leviatan, Karl-Hermann Neeb, Christoph Schweigert, Yuji Tachikawa, Luc Vinet and Joshua Zak. Next to the plenary talks, there were 170 talks in six parallel sessions and 10 poster presentations. All scientific activities took place in the Joseph Plateau Building of the Faculty of Engineering and Architecture of Ghent University, a historical building conveniently located in the city centre of Ghent. In this building we could make use of the main lecture hall (400 seats) for the plenary lectures, six lecture rooms for parallel sessions, two offices for organizational activities and registrations, two PC-rooms and a large foyer for coffee breaks, book exhibitions and the poster session. As part of the colloquium, a

  13. Constructing a Weyl semimetal by stacking one-dimensional topological phases

    NASA Astrophysics Data System (ADS)

    Ganeshan, Sriram; Das Sarma, S.

    2015-03-01

    Topological semimetals in three-dimensions (e.g., a Weyl semimetal) can be built by stacking two-dimensional topological phases. The interesting aspect of such a construction is that even though the topological building blocks in the low dimension may be gapped, the higher dimensional semimetallic phase emerges as a gapless critical point of a topological phase transition between two distinct insulating phases. In this work, we extend this idea by constructing three-dimensional topological semimetallic phases akin to Weyl systems by stacking one-dimensional Aubry-Andre-Harper (AAH) lattice tight-binding models with nontrivial topology. The generalized AAH model is a family of one-dimensional tight-binding models with cosine modulations in both hopping and on-site energy terms. In this paper, we present a two-parameter generalization of the AAH model that can access topological phases in three dimensions within a unified framework. We show that the π -flux state of this two-parameter AAH model manifests three-dimensional topological semimetallic phases where the topological features are embedded in one dimension. The topological nature of the band touching points of the semimetallic phase in 3D is explicitly established both analytically and numerically from the 1D perspective. This dimensional reduction provides a simple protocol to experimentally construct the three-dimensional Brillouin zone of the topological semimetallic phases using "legos" of simple 1D double well optical lattices. We also propose Zak phase imaging of optical lattices as a tool to capture the topological nature of the band touching points. Our work provides a theoretical connection between the commensurate AAH model in 1D and Weyl semimetals in 3D, and points toward practical methods for the laboratory realization of such three-dimensional topological systems in atomic optical lattices.

  14. Room Temperature Line Lists for CO_2 Isotopologues with AB Initio Computed Intensities

    NASA Astrophysics Data System (ADS)

    Zak, Emil; Tennyson, Jonathan; Polyansky, Oleg; Lodi, Lorenzo; Zobov, Nikolay Fedorovich; Tashkun, Sergey; Perevalov, Valery

    2016-06-01

    We report 13 room temperature line lists for all major CO_2 isotopologues, covering 0-8000 wn. These line lists are a response to the need for line intensities of high, preferably sub-percent, accuracy by remote sensing experiments. Our scheme encompasses nuclear motion calculations supported by critical reliability analysis of the generated line intensities. Rotation-vibration wavefunctions and energy levels are computed using DVR3D and a high quality semi-empirical potential energy surface (PES) [1], followed by computation of intensities using a fully ab initio dipole moment surface (DMS). Cross comparison of line lists calculated using pairs of high-quality PES's and DMS's is used to assess imperfections in the PES, which lead to unreliable transition intensities between levels involved in resonance interactions. Four line lists are computed for each isotopologue to quantify sensitivity to minor distortions of the PES/DMS. This provides an estimate of the contribution to the overall line intensity error introduced by the underlying PES. Reliable lines are benchmarked against recent state-of-the-art measurements [2] and HITRAN-2012 supporting the claim that the majority of line intensities for strong bands are predicted with sub-percent accuracy [3]. Accurate line positions are generated using an effective Hamiltonian [4]. We recommend use of these line lists for future remote sensing studies and inclusions in databases. X. Huang, D. W. Schwenke, S. A. Tashkun, T. J. Lee, J. Chem. Phys. 136, 124311, 2012. O. L. Polyansky, K. Bielska, M. Ghysels, L. Lodi, N. F. Zobov, J. T. Hodges, J. Tennyson, PRL, 114, 243001, 2015. E. Zak, J. Tennyson, O. L. Polyansky, L. Lodi, S. A. Tashkun, V. I. Perevalov, JQSRT, in press and to be submitted. S. A. Tashkun, V. I. Perevalov, R. R. Gamache, J. Lamouroux, JQSRT, 152, 45-73, 2015.

  15. S Parameter in the Holographic Walking/Conformal Technicolor

    NASA Astrophysics Data System (ADS)

    Haba, K.; Matsuzaki, S.; Yamawaki, K.

    2008-10-01

    We explicitly calculate the S parameter in entire parameter space of the holographic walking/conformal technicolor (W/C TC), based on the deformation of the holographic QCD by varying the anomalous dimension from γ_m ≃ 0 through γ_m ≃ 1 continuously. The S parameter is given as a positive monotonic function of ξ which is fairly insensitive to γ_m and continuously vanishes as S ˜ ξ^2 to 0 when ξ to 0, where ξ is the vacuum expectation value of the bulk scalar field at the infrared boundary of the 5th dimension z = z_m and is related to the mass of (techni-) ρ meson (M_ρ) and the decay constant (f_π) as ξ ˜ f_π z_m ˜ f_π/M_ρ for ξ ≪ 1. However, although ξ is related to the techni-fermion condensate < bar{T}T >, we find no particular suppression of ξ and hence of S due to large γ_m, based on the correct identification of the renormalization-point dependence of < bar{T}T > in contrast to the literature. Then we argue possible behaviors of f_π/M_ρ as < bar{T}T > to 0 near the conformal window characterized by the Banks-Zaks infrared fixed point in more explicit dynamics with γ_m ≃ 1. It is a curious coincidence that the result from ladder Schwinger-Dyson and Bethe-Salpeter equations well fits in the parameter space obtained in this paper. When f_π/M_ρ to 0 is realized, the holography suggests a novel possibility that f_π vanishes much faster than the dynamical mass m does.

  16. Best Practice Guide for the Treatment of Nightmare Disorder in Adults

    PubMed Central

    Aurora, R. Nisha; Zak, Rochelle S.; Auerbach, Sanford H.; Casey, Kenneth R.; Chowdhuri, Susmita; Karippot, Anoop; Maganti, Rama K.; Ramar, Kannan; Kristo, David A.; Bista, Sabin R.; Lamm, Carin I.; Morgenthaler, Timothy I.

    2010-01-01

    Summary of Recommendations: Prazosin is recommended for treatment of Posttraumatic Stress Disorder (PTSD)-associated nightmares. Level A Image Rehearsal Therapy (IRT) is recommended for treatment of nightmare disorder. Level A Systematic Desensitization and Progressive Deep Muscle Relaxation training are suggested for treatment of idiopathic nightmares. Level B Venlafaxine is not suggested for treatment of PTSD-associated nightmares. Level B Clonidine may be considered for treatment of PTSD-associated nightmares. Level C The following medications may be considered for treatment of PTSD-associated nightmares, but the data are low grade and sparse: trazodone, atypical antipsychotic medications, topiramate, low dose cortisol, fluvoxamine, triazolam and nitrazepam, phenelzine, gabapentin, cyproheptadine, and tricyclic antidepressants. Nefazodone is not recommended as first line therapy for nightmare disorder because of the increased risk of hepatotoxicity. Level C The following behavioral therapies may be considered for treatment of PTSD-associated nightmares based on low-grade evidence: Exposure, Relaxation, and Rescripting Therapy (ERRT); Sleep Dynamic Therapy; Hypnosis; Eye-Movement Desensitization and Reprocessing (EMDR); and the Testimony Method. Level C The following behavioral therapies may be considered for treatment of nightmare disorder based on low-grade evidence: Lucid Dreaming Therapy and Self-Exposure Therapy. Level C No recommendation is made regarding clonazepam and individual psychotherapy because of sparse data. Citation: Aurora RN; Zak RS; Auerbach SH; Casey KR; Chowduri S; Krippot A; Maganti RK; Ramar K; Kristo DA; Bista SR; Lamm CI; Morgenthaler TI. Best practice guide for the treatment of nightmare disorder in adults. J Clin Sleep Med 2010;6(4):389-401. PMID:20726290

  17. Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes.

    PubMed

    Filippov, Valery; Schmidt, Erin L; Filippova, Maria; Duerksen-Hughes, Penelope J

    2008-08-15

    Alternative splicing is an important source of protein diversity, and is an established but not yet fully understood mechanism for gene regulation in higher eukaryotes. Its regulation is governed by a variety of mechanisms, including variation in the expression levels of splicing factors engaged in spliceosome formation. SRp55 is one of the most ubiquitous splicing factors and one that can be up-regulated by DNA damage in the absence of p53, and we had previously found that depletion of its activity increased resistance to DNA damage in p53-dependant manner. To assess its influence on the splicing patterns of genes involved in apoptosis, we performed splice-specific microarray analysis of cells treated with siRNA specific for this gene. This analysis, backed by RT-PCR verification, identified three genes, KSR1, ZAK and mda7/IL24, which are sensitive to SRp55 depletion. We also analyzed the splice patterns of apoptosis-related genes in p53-deficient U2OS cells following treatment with the genotoxic drug mitomycin C. This analysis revealed that DNA damage resulted in changes in splicing activity that modified the splicing pattern of Fas, a key pro-apoptotic, p53-inducible death receptor. Interestingly, this modification led to an enrichment of the anti-apoptotic soluble Fas isoform, and this secreted isoform was detected in the media surrounding cells subjected to DNA damage. These findings show that modulation of splicing activity in p53-deficient cells during the early response to sub-lethal DNA damage results in a change in the splicing of target genes, thus modifying the cellular response to genotoxic agents.

  18. Impact of river regulation on potential sediment mobilization and transport in an Alpine catchment

    NASA Astrophysics Data System (ADS)

    Costa, Anna; Molnar, Peter; Lane, Stuart N.; Bakker, Maarten

    2015-04-01

    The upper Rhône basin (upstream of Lake Geneva) has been heavily affected by human activities during the last century. The most evident impacts are related to river regulation, specifically flow impoundement, flow abstraction and channelization. In the last century and mainly since 1960, several large dams have been built along the main tributaries of the Rhône River, resulting in the water storage of a volume equal to 20% of the total annual river flow. The dams are part of hydropower systems which abstract water from streams and transfer it through complex networks (intakes, tunnels and pumping stations) to the reservoirs. Hydropower production leads to regulated flow in the Rhône: mostly an increase of winter flows, a reduction of summer flows, and a decrease of flood peaks. The sediment supply into Lake Geneva has decreased following dam construction (Loizeau & Dominik, 2000) due to the storage of sediment in upstream reservoirs, in rivers with reduced sediment transport capacity due to flow abstraction, and due to the development of sediment mining. Our hypothesis is that streamflow regulation itself has dramatically impacted the sediment transport dynamics of the system. We investigate the impacts of flow regulation on the sediment transport regime, by analysing the effects on potential sediment transport capacity (bedload). By the use of different bedload transport formulae (Meyer-Peter Müller, Wilcock and Crowe), the potential sediment transport capacity is computed at different cross sections within the basin. Potential sediment mobility occurs when the applied bed shear stress exceeds a critical value, τ>τc. The applied bed shear stress is computed as τ=ρghS, with water depth (h) measured from rating curves. We obtain an estimate of the energy slope (S) from the analysis of the river cross section, assuming uniform flow. The critical value of bed shear stress τc is computed using empirical formulae as a function of the grain diameter (ds). To

  19. Spitzer spectroscopy of newly discovered clusters of star formation in Serpens

    NASA Astrophysics Data System (ADS)

    Merín, B.; Pontoppidan, K. M.; Geers, V. C.; Dullemond, C. P.; Harvey, P.; van Dishoeck, E. F.; Augereau, J. C.; Kessler, J.; Boogert, A. C. A.; C2d Team

    We have discovered a uniquely rich star-forming region covering 0.5 sq. degrees near the Serpens Core from IRAC/MIPS maps obtained with the Spitzer Space Telescope within the Cores to Disks (c2d) Legacy program. The region contains three clusters apparently at different evolutionary stages, suggesting that sequential star formation has taken place. A number of the sources in this sample has been observed with the IRS spectrometer and will be presented and analysed here in relation to the general evolutionary picture for the region. In particular, the spectra contain signatures of silicates allowing the detailed comparison of grain composition, crystallinity, size distribution as well as physical structure of the disks between illustrative objects in the region at different evolutionary stages. 1. Introduction Mounting evidence points to the period between 1 and 10 Myrs as the most probable time-scale for the evolution of the circumstellar disks around young stars and the possible formation of planets. For example, the inner hot dust as traced by near-infrared photometry has been found to disperse within 3-6 Myrs (Haish et al. 2001). The dust has also been observed to crystallize due to thermal annealing in the innermost parts followed by strong radial mixing (van Boekel et al. 2004). Mid-infrared spectra coupled with disk models indicate that disks evolve from a flared geometry to a flat self-shadowed geometry (Meeus et al. 2001), as grains grow and settle to the mid-plane (Dullemond & Dominik 2004). Most of these previous studies are based on spectra of a handful of objects spread across the sky. A better statistical picture of disk evolution can be obtained by comparing disk populations in different co-eval clusters. 2. New star forming clusters in Serpens As part of the Cores to Disks (c2d) Legacy mapping campaign of molecular clouds (Evans et al. 2003), we discovered a region of ~0.5 square degrees in the Serpens molecular cloud (d ~ 250 pc) that is very rich

  20. PREFACE: Nano- and microfluidics Nano- and microfluidics

    NASA Astrophysics Data System (ADS)

    Jacobs, Karin

    2011-05-01

    compressible fluids Kerstin Falk and Klaus Mecke Wetting, roughness and flow boundary conditions Olga I Vinogradova and Aleksey V Belyaev Molecular transport and flow past hard and soft surfaces: computer simulation of model systems F Léonforte, J Servantie, C Pastorino, and M Müller Simulations of slip flow on nanobubble-laden surfaces J Hyväluoma, C Kunert and J Harting Electrophoretic transport of biomolecules across liquid-liquid interfaces Thomas Hahn, Götz Münchow and Steffen Hardt Wetting morphologies and their transitions in grooved substrates Ralf Seemann, Martin Brinkmann, Stephan Herminghaus, Krishnacharya Khare, Bruce M Law, Sean McBride, Konstantina Kostourou, Evgeny Gurevich, Stefan Bommer, Carsten Herrmann and Dominik Michler Imbibition in mesoporous silica: rheological concepts and experiments on water and a liquid crystal Simon Gruener, and Patrick Huber Theory and simulations of water flow through carbon nanotubes: prospects and pitfalls Douwe Jan Bonthuis, Klaus F Rinne, Kerstin Falk, C Nadir Kaplan, Dominik Horinek, A Nihat Berker, Lydéric Bocquet, and Roland R Netz Structure and flow of droplets on solid surfaces P Müller-Buschbaum, D Magerl, R Hengstler, J-F Moulin, V Körstgens, A Diethert, J Perlich, S V Roth, M Burghammer, C Riekel, M Gross, F Varnik, P Uhlmann, M Stamm, J M Feldkamp and C G Schroer Stability and dynamics of droplets on patterned substrates: insights from experiments and lattice Boltzmann simulations F Varnik, M Gross, N Moradi, G Zikos, P Uhlmann, P Müller-Buschbaum, D Magerl, D Raabe, I Steinbach and M Stamm Micro-capsules in shear flow R Finken, S Kessler and U Seifert Micro-rheology on (polymer-grafted) colloids using optical tweezers C Gutsche, M M Elmahdy, K Kegler, I Semenov, T Stangner, O Otto, O Ueberschär, U F Keyser, M Krueger, M Rauscher, R Weeber, J Harting, Y W Kim, V Lobaskin, R R Netz, and F Kremer Dynamics of colloids in confined geometries L Almenar and M Rauscher Dynamics of red blood cells and vesicles in

  1. Analytical singlet α{/s 4} QCD contributions into the e + e --annihilation Adler function and the generalized Crewther relations

    NASA Astrophysics Data System (ADS)

    Kataev, A. L.

    2012-02-01

    The generalized Crewther relations in the channels of the non-singlet and vector quark currents are considered. These relations follow from the double application of the operator product expansion approach to the same axial vector-vector-vector triangle amplitude in two regions, adjoining to the angle sides ( x, y) (or p 2, q 2). We assume that the generalized Crewther relations in these two kinematic regimes result in the existence of the same perturbation expression for two products of the coefficient functions of annihilation and deepinelastic scattering processes in the non-singlet and vector channels. This feature explains the conformal symmetry motivated cancellations between the singlet α{/s 3} corrections to the Gross-Llewellyn Smith sum rule S GLS of ν N deep inelastic scattering and the singlet α{/s 3} correction to the e + e --annihilation Adler function D {/A V } in the product of the corresponding perturbative series. Taking into account the Baikov-Chetyrkin-Kuhn fourth order result for S GLS and the perturbative effects of the violation of the conformal symmetry in the generalized Crewther relation, we obtain the analytical contribution to the singlet α{/s 4} correction to the D {/A V } function. Its a-posteriori comparison with the recent result of direct diagram-by-diagram evaluation of the singlet fourth order corrections to D {/A V } function demonstrates the coincidence of the predicted and obtained ζ{3/2}-contributions to the singlet term. They can be obtained in the conformal invariant limit from the original Crewther relation. Therefore, on the contrary to previous belief, the appearance of ζ3-terms in the perturbative series in quantum field theory gauge models does not contradict to the property of the conformal symmetry and can be considered as regular feature. The Banks-Zaks motivated relation between our predicted and the obtained directly fourth order corrections is mentioned. It confirms the expectation, previously made by Baikov

  2. Use of Cad Systems in Testing the Collision of Underground Transportation Means / Zastosowanie systemów Cad w badaniach kolizyjności środków transportu podziemnego

    NASA Astrophysics Data System (ADS)

    Dudek, Marek

    2013-06-01

    A concept of use of CAD systems in testing collision of underground transportation means is presented. Reasons for undertaking this problem are given with end users identified. The concept of the system for collision analyses of transported loads is described. Examples of collision analysis during transportation of powered roof support are given. Presented system is designed to aid planning, organizational and training activities undertaken in management of transportation safety in mines. It will be also possible to use software resources, developed within the system as the didactic material as regards safe transportation process, which include hazards to the employees working in the area of transportation operations. Developed prototype of a system for testing the collision of underground transportation means was positively assessed by employees of the Coal Company, JSC - industrial partner of KOMAG. This prototype is continuously improved and adapted for commercial implementation in the selected coal mines. W pracy przedstawiono koncepcję zastosowania systemów CAD w badaniach kolizyjności środków transportu podziemnego. Określono przyczyny podjęcia tematu oraz zidentyfikowano końcowych użytkowników. Zaprezentowano koncepcję systemu do analiz kolizyjności transportowanych ładunków. Pokazano przykłady analizy kolizyjności podczas transportu sekcji obudowy zmechanizowanej. Przedstawiony system przeznaczony jest do wspomagania działań planistycznych, organizacyjnych i szkoleniowych podejmowanych w zarządzaniu bezpieczeństwem transportu w zakładach górniczych. Opracowane w ramach systemu zasoby programowe będzie można również wykorzystać jako materiał dydaktyczny z zakresu bezpieczeństwa pracy w transporcie, uwzględniający zagrożenia dla pracowników pracujących w bezpośredniej strefie prac transportowych. Opracowany prototyp systemu do badania kolizyjności środków transportu podziemnego został pozytywnie oceniony przez pracownik

  3. Underground Lead-Zinc Mine Production Planning Using Fuzzy Stochastic Inventory Policy / Planowanie Wydobycia Cynku I Ołowiu W Kopalniach Podziemnych Z Wykorzystaniem Podejścia Stochastycznego Z Elementami Logiki Rozmytej Do Określania Niezbędnego Poziomu Zapasów

    NASA Astrophysics Data System (ADS)

    Gligoric, Zoran; Beljic, Cedomir; Gluscevic, Branko; Cvijovic, Cedomir

    2015-03-01

    Methodology for long-term underground lead-zinc mine planning based on fuzzy inventory theory is presented in this paper. We developed a fuzzy stochastic model of inventory control problem for planning lead-zinc ore production under uncertainty. The final purpose of this article is to find the optimal quantity of mined ore that should be stockpiled, in order to enable "feeding" of mineral processing plant in cases when the production in underground mine is interrupted, by using Possibilistic mean value of fuzzy number for defuzzing the fuzzy total annual inventory costs, and by using Extension of the Lagrangean method for solving inequality constrain problem. The different types of costs involved in mined ore inventory problems affect the efficiency of production scheduling. Dynamic nature of lead and zinc metal price is described by Ornstein-Uhlenbeck stochastic mean reverting process. The model is illustrated with a numerical example. W pracy przedstawiono metodologię długoterminowego wydobycia cynku i ołowiu w kopalniach podziemnych z wykorzystaniem podejścia stochastycznego z elementami logiki rozmytej do określania wymaganego poziomu zapasów. Opracowaliśmy model stochastyczny z wykorzystaniem elementów logiki rozmytej do kontroli zapasów w planowaniu wydobycia cynku i ołowiu w warunkach niepewności. Celem końcowym pracy jest określenie optymalnej ilości wydobywanej rudy, którą należy zachować jako zapas tak aby zapewnić odpowiednie jej dostawy do zakładu przeróbczego nawet w przypadku przerwania wydobycia w kopalni podziemnej, opierając się na posybilistycznej wartości średniej liczby rozmytej i wyostrzeniu całkowitych rocznych kosztów zapasów. Wykorzystano także rozszerzenie metody Lagrange'a do rozwiązywania problemu więzów w nierówności. Różnorakie koszty związane ze składowaniem zapasów wydobywanej rudy mają wpływ na wydajność planowanej produkcji. Dynamiczne zmiany cen cynku i o

  4. Effect of destablized reactions using lithium amide (LiNH2) and doping using titanium based catalyst on the desorption characteristics of lithuim aluminium hydride (LiAlH4)

    NASA Astrophysics Data System (ADS)

    Paravasthu, Siddharth

    In the past few decades there has been a tremendous increase in hydrogen storage research. Numerous materials and material systems have been studied as potential candidates for hydrogen storage, but unfortunately none of those materials demonstrate enough hydrogen releasing capacity under suitable temperature range to be used for hydrogen storage. Research promises to unlock the potential of these materials and ultimately lead to the commercialization of this technology. LiAlH4 is one of those materials that have been exclusively studied as a candidate for hydrogen storage due to its high theoretical hydrogen storage capacity, and its ability to release hydrogen in more than one step at different temperature ranges. Jun Lu and Zhigang Zak Fang studied the effects of titanium based catalyst (TiCl3.1/3AlCl3) and destabilization reactions using LiNH2 on LiAlH4, but did not demonstrate the effects of ball milling on the system. In the present work we have investigated the effects of ball milling, and the effects of destabilization reaction using LiNH2 on the hydrogen release characteristics of LiAlH4 doped with TiCl3. The current market scenario for fuel cell technology and the possibility and consequences of introducing the current system in the market has been briefly discussed. X-ray powder diffraction, thermo-gravimetric analysis and scanning electron microscopy were employed for the characterization of the samples. Both the compounds LiNH2, and TiCl3 worked in effecting the dehydrogenation kinetics of LiAlH4. The duration of ball milling required to affect the dehydrogenation kinetics of LiAlH 4 using TiCl3 was optimized. A hydrogen release of 7.3 wt% was observed from the final system i.e. (LiAlH4 LiNH2 doped with 2% TiCl3) at temperatures below 400°C.

  5. Technidilaton at the conformal edge

    SciTech Connect

    Hashimoto, Michio; Yamawaki, Koichi

    2011-01-01

    Technidilaton (TD) was proposed long ago in the technicolor near criticality/conformality. To reveal the critical behavior of TD, we explicitly compute the nonperturbative contributions to the scale anomaly <{theta}{sub {mu}}{sup {mu}>} and to the technigluon condensate <{alpha}G{sub {mu}{nu}}{sup 2}>, which are generated by the dynamical mass m of the technifermions. Our computation is based on the (improved) ladder Schwinger-Dyson equation, with the gauge coupling {alpha} replaced by the two-loop running coupling {alpha}({mu}) having the Caswell-Banks-Zaks infrared fixed point {alpha}{sub *}: {alpha}({mu}){approx_equal}{alpha}={alpha}{sub *} for the infrared region m<{mu}<{Lambda}{sub TC}, where {Lambda}{sub TC} is the intrinsic scale (analogue of {Lambda}{sub QCD} of QCD) relevant to the perturbative scale anomaly. We find that -<{theta}{sub {mu}}{sup {mu}}>/m{sup 4}{yields}const{ne}0 and <{alpha}G{sub {mu}}{nu}{sup 2}>/m{sup 4}{yields}({alpha}/{alpha}{sub cr}-1){sup -3/2}{yields}{infinity} in the criticality limit m/{Lambda}{sub TC}{approx}exp(-{pi}/({alpha}/{alpha}{sub cr}-1){sup 1/2}){yields}0 ({alpha}={alpha}{sub *}=>{alpha}{sub cr}, or N{sub f} approaches N{sub f}{sup cr}) ('conformal edge'). Our result precisely reproduces the formal identity <{theta}{sub {mu}}{sup {mu}>}=({beta}({alpha})/4{alpha}{sup 2})<{alpha}G{sub {mu}{nu}}{sup 2}>, where {beta}({alpha})={Lambda}{sub TC}({partial_derivative}{alpha}/{partial_derivative}{Lambda}{sub TC})=-(2{alpha}{sub cr}/{pi}){center_dot}({alpha}/{alpha}{sub cr}-1){sup 3/2} is the nonperturbative beta function corresponding to the above essential singularity scaling of m/{Lambda}{sub TC}. Accordingly, the partially conserved dilatation current implies (M{sub TD}/m){sup 2}(F{sub TD}/m){sup 2}=-4<{theta}{sub {mu}}{sup {mu}}>/m{sup 4}{yields}const{ne}0 at criticality limit, where M{sub TD} is the mass of TD and F{sub TD} the decay constant of TD. We thus conclude that at criticality limit the TD could become a ''true

  6. Results of the Promethee Method Application in Selecting the Technological System at the Majdan III Open Pit Mine / Wyniki Zastosowania Metody Promethee do Wyboru Systemu Technologicznego W Kopalni Odkrywkowej Majdan III

    NASA Astrophysics Data System (ADS)

    Vujić, Slobodan; Hudej, Marjan; Miljanović, Igor

    2013-12-01

    This paper discusses the application of the PROMETHEE model and the results achieved in practice, following the example of the multi-criteria selection of the technological system at the Majdan III clay mineral raw material open pit mine of the Potisje Company, Republic of Serbia. After the introduction comments, reasons are explained for selecting the new technological system, conditions and limitations for the seven alternative solutions considered are described, mathematical foundation for the PROMETHEE method and a multi-criteria model of the problem in question are presented. The solution with the following structure was ranked first and accepted by the Company management as the best: Bucket chain excavator - Conveyor belts - Spreader (ECS), alongside a decision is made on the acquisition of machinery and system construction. The system was put into operation in 2000. The experience and the data accumulated in the previous twelve years confirm that the decision made on the application of the ECS technology was just, and the conclusion lists the benefits achieved. W artykule omówiono zastosowanie modelu Promethee i przedyskutowano uzyskane w ten sposób wyniki na przykładzie wielokryterialnego wyboru systemu technologicznego do zastosowania w kopalni odkrywkowej minerałów ilastych Majdan III, należącej do przedsiębiorstwa górniczego Potisje (Republika Serbii). Po uwagach wprowadzających przedstawiono powody wyboru nowego ciągu technologicznego, omówiono warunki oraz ograniczenia dla siedmiu alternatywnych rozwiązań, podstawy matematyczne metody Promethee oraz wielokryterialny model zagadnienia. Rozwiązanie uznane za najlepsze i zaaprobowane przez zarząd przedsiębiorstwa zakłada zastosowanie następującego ciągu technologicznego: koparka łancuchowa jednonaczyniowa - przenośniki taśmowe - rozkładarka(system ECS). Podjęto także decyzje odnośnie zakupu sprzętu i instalacji systemu, który uruchomiony został w 2000 roku. Doświadczenia i

  7. Regional model studies of the atmospheric dispersion of fine volcanic ash after the eruption of Eyjafjallajoekull

    NASA Astrophysics Data System (ADS)

    Langmann, B.; Hort, M. K.

    2010-12-01

    During the eruption of Eyjafjallajoekull on Iceland in April/May 2010 air traffic over Europe was repeatedly interrupted because of volcanic ash in the atmosphere. This completely unusual situation in Europe leads to the demand of improved crisis management, e.g. European wide regulations of volcanic ash thresholds and improved forecasts of theses thresholds. However, the quality of the forecast of fine volcanic ash concentrations in the atmosphere depends to a great extent on a realistic description of the erupted mass flux of fine ash particles, which is rather uncertain. Numerous aerosol measurements (ground based and satellite remote sensing, and in situ measurements) all over Europe have tracked the volcanic ash clouds during the eruption of Eyjafjallajoekull offering the possibility for an interdisciplinary effort between volcanologists and aerosol researchers to analyse the release and dispersion of fine volcanic ash in order to better understand the needs for realistic volcanic ash forecasts. This contribution describes the uncertainties related to the amount of fine volcanic ash released from Eyjafjallajoekull and its influence on the dispersion of volcanic ash over Europe by numerical modeling. We use the three-dimensional Eulerian atmosphere-chemistry/aerosol model REMOTE (Langmann et al., 2008) to simulate the distribution of volcanic ash as well as its deposition after the eruptions of Eyjafjallajoekull during April and May 2010. The model has been used before to simulate the fate of the volcanic ash after the volcanic eruptions of Kasatochi in 2008 (Langmann et al., 2010) and Mt. Pinatubo in 1991. Comparing our model results with available measurements for the Eyjafjallajoekull eruption we find a quite good agreement with available ash concentrations data measured over Europe as well as with the results from other models. Langmann, B., K. Zakšek and M. Hort, Atmospheric distribution and removal of volcanic ash after the eruption of Kasatochi volcano

  8. Technidilaton at the conformal edge

    NASA Astrophysics Data System (ADS)

    Hashimoto, Michio; Yamawaki, Koichi

    2011-01-01

    Technidilaton (TD) was proposed long ago in the technicolor near criticality/conformality. To reveal the critical behavior of TD, we explicitly compute the nonperturbative contributions to the scale anomaly ⟨θμμ⟩ and to the technigluon condensate ⟨αGμν2⟩, which are generated by the dynamical mass m of the technifermions. Our computation is based on the (improved) ladder Schwinger-Dyson equation, with the gauge coupling α replaced by the two-loop running coupling α(μ) having the Caswell-Banks-Zaks infrared fixed point α*: α(μ)≃α=α* for the infrared region m<μ<ΛTC, where ΛTC is the intrinsic scale (analogue of ΛQCD of QCD) relevant to the perturbative scale anomaly. We find that -⟨θμμ⟩/m4→const≠0 and ⟨αGμν2⟩/m4→(α/αcr-1)-3/2→∞ in the criticality limit m/ΛTC˜exp⁡(-π/(α/αcr-1)1/2)→0 (α=α*↘αcr, or Nf↗Nfcr) (“conformal edge”). Our result precisely reproduces the formal identity ⟨θμμ⟩=(β(α)/4α2)⟨αGμν2⟩, where β(α)=ΛTC(∂α)/(∂ΛTC)=-(2αcr/π)·(α/αcr-1)3/2 is the nonperturbative beta function corresponding to the above essential singularity scaling of m/ΛTC. Accordingly, the partially conserved dilatation current implies (MTD/m)2(FTD/m)2=-4⟨θμμ⟩/m4→const≠0 at criticality limit, where MTD is the mass of TD and FTD the decay constant of TD. We thus conclude that at criticality limit the TD could become a “true (massless) Nambu-Goldstone boson” MTD/m→0, only when m/FTD→0, namely, getting decoupled, as was the case of “holographic technidilaton” of Haba-Matsuzaki-Yamawaki. The decoupled TD can be a candidate of dark matter.

  9. Walking on the ladder: 125 GeV technidilaton, or Conformal Higgs

    NASA Astrophysics Data System (ADS)

    Matsuzaki, Shinya; Yamawaki, Koichi

    2015-12-01

    The walking technicolor based on the ladder Schwinger-Dyson gap equation is studied, with the scale-invariant coupling being an idealization of the Caswell-Banks-Zaks infrared fixed point in the "anti-Veneziano limit", such that N C → ∞ with N C · α( μ 2) = fixed and N F / N C = fixed (≫1), of the SU( N C ) gauge theory with massless N F flavors near criticality. We show that the 125 GeV Higgs can be naturally identified with the technidilaton (TD) predicted in the walking technicolor, a pseudo Nambu-Goldstone (NG) boson of the spontaneous symmetry breaking of the approximate scale symmetry. Ladder calculations yield the TD mass M ϕ from the trace anomaly as {M}_{φ}^2{F}_{φ}^2=-4<{θ}_{μ}^{μ}> =-β (α ({μ}^2))/α ({μ^2)}< {G}_{λ ν}^2({μ}^2)> ˜eq {N}_C{N}_F16/π^4{m}_F^4 , independently of the renormalization point μ, where m F is the dynamical mass of the technifermion, and {F}_{φ }=O(√{N_F{N}_C}{m}_F) the TD decay constant. It reads {M}_{φ}^2˜eq {(\\upsilon_{EW}/2\\cdot 5{\\upsilon}_{EW}/F_{φ })}^2\\cdot [8/N_F4/N_C],({\\upsilon}_{EW}=246GeV) , which implies F ϕ ≃ 5 v EW for M ϕ ≃ 125 GeV ≃ 1/2 v EW in the one-family model ( N C = 4 , N F = 8), in good agreement with the current LHC Higgs data. The result reflects a generic scaling M ϕ 2 / υ EW 2 ˜ M ϕ 2 / F ϕ 2 ˜ m F 2 / F ϕ 2 ˜ 1/( N F N C ) → 0 as a vanishing trace anomaly, namely the TD has a mass vanishing in the anti-Veneziano limit, similarly to η' meson as a pseudo-NG boson of the ordinary QCD with vanishing U(1) A anomaly in the Veneziano limit ( N F / N C ≪ 1).

  10. The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses

    PubMed Central

    Aurora, R. Nisha; Chowdhuri, Susmita; Ramar, Kannan; Bista, Sabin R.; Casey, Kenneth R.; Lamm, Carin I.; Kristo, David A.; Mallea, Jorge M.; Rowley, James A.; Zak, Rochelle S.; Tracy, Sharon L.

    2012-01-01

    CSAS. (OPTION)The use of zolpidem and triazolam may be considered for the treatment of primary CSAS only if the patient does not have underlying risk factors for respiratory depression. (OPTION)The following possible treatment options for CSAS related to end-stage renal disease may be considered: CPAP, supplemental oxygen, bicarbonate buffer use during dialysis, and nocturnal dialysis. (OPTION) Citation: Aurora RN; Chowdhuri S; Ramar K; Bista SR; Casey KR; Lamm CI; Kristo DA; Mallea JM; Rowley JA; Zak RS; Tracy SL. The treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses. SLEEP 2012;35(1):17-40. PMID:22215916

  11. Correction of location of boundaries in cadastre modernization process

    NASA Astrophysics Data System (ADS)

    Hanus, Paweł

    2013-06-01

    Modernization of lands and buildings register, which is run in Poland now, assumes capturing boundaries location data by various methods. They are: direct measurement preceded by determining of boundaries in the presence of parties, photogrammetric method, cartographic method, using existing maps being in analogue form. These methods not always assure accuracy. In the paper, an idea of correcting of location of boundary points which do not fulfil accuracy requirements has been presented. These corrections have been computed by assumption of invariability of parcel area revealed in register, so far. Such way of operation from one side would avoid many misunderstandings and difficulties by applying data collected in cadastre and from the other side will not disturb used procedures, which aim is to determine boundary of parcels with demanded accuracy. Modernizacja ewidencji gruntów i budynków, która obecnie jest przeprowadzana w Polsce, zakłada pozyskiwanie współrzędnych punktów granicznych różnymi metodami. Są to: metoda pomiaru bezposredniego, poprzedzona ustaleniem granic w terenie w obecności stron, metoda fotogrametryczna, metoda kartometryczna, wykorzystująca istniejące mapy analogowe. Metody te nie zawsze zapewniają dokładność właściwą dla szczegółów I grupy dokładnościowej. Zgodnie z obowiązującymi przepisami, gdy dokładność określenia położenia punktu załamania granicy nie spełnia standardów technicznych, w ewidencji gruntów i budynków zachowuje się dotychczasową powierzchnię działki. Utrzymana, zatem zostaje rozbieżność pomiędzy powierzchniami geodezyjną a ewidencyjną działki. W artykule przedstawiono koncepcje wprowadzenia poprawek do współrzędnych punktów granicznych, które nie spełniają wymogów dokładnościowych. Poprawki te obliczone zostały przy założeniu warunku niezmienności pola powierzchni działki ewidencyjnej dotychczas ujawnionego w rejestrze gruntów. Taki sposób post

  12. Extending the Standard Model with Confining and Conformal Dynamics

    NASA Astrophysics Data System (ADS)

    McRaven, John Emory

    would leave very little of its energy in the calorimeter, so while detecting the presence of a heavy stable state would be easy, measuring the strength of the detecting it would require accurate measurements of missing energy, or the ability to identify it in the muon tracker. We then study the phenomenology of a 4D model of electroweak symmetry breaking through the condensation of magnetic monopoles. A new generation of fermions with magnetic charges in addition to electric charges is introduced. The dyons condense and break the electroweak symmetry. The magnetic coupling is inversely proportional to the electric coupling, causing it to be strong. The processes involving magnetic couplings thus provide interesting phenomenology to study. We primarily study the processes involving di-photon production and compare it to early LHC results. Finally, we calculate triangle anomalies for fermions with non-canonical scaling dimensions. The most well known example of such fermions (aka unfermions) occurs in Seiberg duality where the matching of anomalies (including mesinos with scaling dimensions between 3/2 and 5/2) is a crucial test of duality. By weakly gauging the non-local action for an unfermion, we calculate the one-loop three-current amplitude. Despite the fact that there are more graphs with more complicated propagators and vertices, we find that the calculation can be completed in a way that nearly parallels the usual case. We show that the anomaly factor for fermionic unparticles is independent of the scaling dimension and identical to that for ordinary fermions. This can be viewed as a confirmation that unparticle actions correctly capture the physics of conformal fixed point theories like Banks-Zaks or SUSY QCD.

  13. Practice Parameters for the Use of Autotitrating Continuous Positive Airway Pressure Devices for Titrating Pressures and Treating Adult Patients with Obstructive Sleep Apnea Syndrome: An Update for 2007

    PubMed Central

    Morgenthaler, Timothy I.; Aurora, R. Nisha; Brown, Terry; Zak, Rochelle; Alessi, Cathy; Boehlecke, Brian; Chesson, Andrew L.; Friedman, Leah; Kapur, Vishesh; Maganti, Rama; Owens, Judith; Pancer, Jeffrey; Swick, Todd J.

    2008-01-01

    significant comorbidities (CHF, COPD, central sleep apnea syndromes, or hypoventilation syndromes); (6) certain APAP devices may be used in an unattended way to determine a fixed CPAP treatment pressure for patients with moderate to severe OSA without significant comorbidities (CHF, COPD, central sleep apnea syndromes, or hypoventilation syndromes); (7) patients being treated with fixed CPAP on the basis of APAP titration or being treated with APAP must have close clinical follow-up to determine treatment effectiveness and safety; and (8) a reevaluation and, if necessary, a standard attended CPAP titration should be performed if symptoms do not resolve or the APAP treatment otherwise appears to lack efficacy. Citation: Morgenthaler TI; Aurora RN; Brown T; Zak R; Alessi C; Boehlecke B; Chesson AL; Friedman L; Kapur V; Maganti R; Owens J; Pancer J; Swick TJ; Standards of Practice Committee of the AASM. Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: An update for 2007. SLEEP 2008;31(1):141-147. PMID:18220088

  14. Isotope characterisation of historical alabaster quarries in Western Europe.

    NASA Astrophysics Data System (ADS)

    Kloppmann, Wolfram; Leroux, Lise; Bromblet, Philippe; Cooper, Anthony H.; Nestler, Angela; Guerrot, Catherine; Montech, Anne-Thérèse; Worley, Noel

    2015-04-01

    ranging from the 14th to 16th century from the Louvre Museum, Cleveland Museum of Fine Arts, the Petit Palais Museum in Avignon and several regional collections and monuments. Burke W. H., Denison R. E., Hetherington E. A., Koepnick R. B., Nelson H. F., and Otto J. B. (1982) Variation of seawater 87Sr/86Sr throughout Phanerozoic time. Geology 10, 516-519. Claypool G. E., Holser W. T., Kaplan I. R., Sakai H., and Zak I. (1980) The age curves of sulfur and oxygen isotopes in marine sulfate and their mutual interpretation. Chem. Geol. 28, 199-260. Denison R. E., Kirkland D. W., and Evans R. (1998) Using strontium isotopes to determine the age and origin of gypsum and anhydrite beds. J. Geol. 106, 1-17. Kloppmann W., Leroux L., Bromblet P., Guerrot C., Proust E., Cooper A. H., Worley N., Smeds S. A., and Bengtsson H. (2014) Tracing Medieval and Renaissance Alabaster Works of Art Back to Quarries: A Multi-Isotope (Sr, S, O) Approach. Archaeometry 56, 203-219.

  15. PREFACE: XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP) (Group30)

    NASA Astrophysics Data System (ADS)

    Brackx, Fred; De Schepper, Hennie; Van der Jeugt, Joris

    2015-04-01

    participants at the Group30 colloquium from 46 different countries. This high number of participants makes the 30th edition of ICGTMP one of the most successful meetings of the series. We were particularly happy with the attendance of 32 students and many young postdocs: this is promising for the future of the research field and of the colloquium series. The attraction of young scientists was promoted by a reduced participation fee, the availability of cheap accommodation in the University Student Guest House, grants from a US-NSF project and grants from the Organising Committee supporting participants from countries with limited financial resources. The colloquium brought together international top researchers, with a variety of different backgrounds but with "group theoretical or algebraic methods" as common ground. The selection of plenary speakers and topics was made by the Organizing Committee, following the suggestions of the International Advisory Committee (consisting of prominent scientists in their domain), and ensuring the diversity of the subjects treated. There were 11 plenary talks, given as well by distinguished world experts as by young rising stars: Matthias Christandl, Alberto De Sole, Rui Loja Fernandes, François Gay-Balmaz, Gitta Kutyniok, Amiram Leviatan, Karl-Hermann Neeb, Christoph Schweigert, Yuji Tachikawa, Luc Vinet and Joshua Zak. Next to the plenary talks, there were 170 talks in six parallel sessions and 10 poster presentations. All scientific activities took place in the Joseph Plateau Building of the Faculty of Engineering and Architecture of Ghent University, a historical building conveniently located in the city centre of Ghent. In this building we could make use of the main lecture hall (400 seats) for the plenary lectures, six lecture rooms for parallel sessions, two offices for organizational activities and registrations, two PC-rooms and a large foyer for coffee breaks, book exhibitions and the poster session. As part of the colloquium, a

  16. Safe Vibrations of Spilling Basin Explosions at "Gotvand Olya Dam" Using Artificial Neural Network

    NASA Astrophysics Data System (ADS)

    Bakhshandeh Amnieh, Hassan; Bahadori, Moein

    2014-12-01

    ów zarejestrowane przy użyciu sejsmografu 3 VIBROLOC. Maksymalna i minimalna odległość pomiędzy środkiem rozkruszanego bloku a stacją rejestrującą ustawiona została na poziomie 244 i 11 m. W celu określenia bezpiecznego poziomu drgań oraz dopuszczalnej wagi ładunku, zastosowano podejście wykorzystujące sieci neuronowe, z wykorzystaniem metody propagacji wstecznej i trzech warstw ukrytych. Błąd średniokwadratowy i współczynnik korelacji sieci wyniosły 1.95 i 0.95, co pozostaje w zgodności z danym uzyskiwanymi z obserwacji empirycznych, wskazując na poprawność i dokładność prognoz. Zakładając wysoki poziom dokładności sieci oraz wysoką dokładność w prognozowaniu poziomu drgań wywołanych przez prace strzałowe, przyjęto że najbliższa odległość od środka rozkruszanego bloku wyniesie 11 m. Uwzględniając standardowe dopuszczalne w przypadku ciężkich budowli betonowych poziomy drgań w wysokości 120 m/s, oszacowano że maksymalna dopuszczalna masa ładunku wyniesie 47.00 Kg, w przeliczeniu na jeden okres zwłoki. Wyniki badań wykorzystane być mogą w planowaniu kolejnych bezpiecznych prac strzałowych.

  17. [Evaluation of using statistical methods in selected national medical journals].

    PubMed

    Sych, Z

    1996-01-01

    The paper covers the performed evaluation of frequency with which the statistical methods were applied in analyzed works having been published in six selected, national medical journals in the years 1988-1992. For analysis the following journals were chosen, namely: Klinika Oczna, Medycyna Pracy, Pediatria Polska, Polski Tygodnik Lekarski, Roczniki Państwowego Zakładu Higieny, Zdrowie Publiczne. Appropriate number of works up to the average in the remaining medical journals was randomly selected from respective volumes of Pol. Tyg. Lek. The studies did not include works wherein the statistical analysis was not implemented, which referred both to national and international publications. That exemption was also extended to review papers, casuistic ones, reviews of books, handbooks, monographies, reports from scientific congresses, as well as papers on historical topics. The number of works was defined in each volume. Next, analysis was performed to establish the mode of finding out a suitable sample in respective studies, differentiating two categories: random and target selections. Attention was also paid to the presence of control sample in the individual works. In the analysis attention was also focussed on the existence of sample characteristics, setting up three categories: complete, partial and lacking. In evaluating the analyzed works an effort was made to present the results of studies in tables and figures (Tab. 1, 3). Analysis was accomplished with regard to the rate of employing statistical methods in analyzed works in relevant volumes of six selected, national medical journals for the years 1988-1992, simultaneously determining the number of works, in which no statistical methods were used. Concurrently the frequency of applying the individual statistical methods was analyzed in the scrutinized works. Prominence was given to fundamental statistical methods in the field of descriptive statistics (measures of position, measures of dispersion) as well as

  18. Practice Parameters for the Clinical Evaluation and Treatment of Circadian Rhythm Sleep Disorders

    PubMed Central

    Morgenthaler, Timothy I.; Lee-Chiong, Teofilo; Alessi, Cathy; Friedman, Leah; Aurora, R. Nisha; Boehlecke, Brian; Brown, Terry; Chesson, Andrew L.; Kapur, Vishesh; Maganti, Rama; Owens, Judith; Pancer, Jeffrey; Swick, Todd J.; Zak, Rochelle

    2007-01-01

    the diagnosis of FRD in sighted and unsighted patients but there is insufficient evidence to recommend their routine use in the diagnosis of SWD, JLD, ASPD, DSPD, or ISWR (Option). Additionally, actigraphy is useful as an outcome measure in evaluating the response to treatment for CRSDs (Guideline). A range of therapeutic interventions were considered including planned sleep schedules, timed light exposure, timed melatonin doses, hypnotics, stimulants, and alerting agents. Planned or prescribed sleep schedules are indicated in SWD (Standard) and in JLD, DSPD, ASPD, ISWR (excluding elderly-demented/nursing home residents), and FRD (Option). Specifically dosed and timed light exposure is indicated for each of the circadian disorders with variable success (Option). Timed melatonin administration is indicated for JLD (Standard); SWD, DSPD, and FRD in unsighted persons (Guideline); and for ASPD, FRD in sighted individuals, and for ISWR in children with moderate to severe psychomotor retardation (Option). Hypnotic medications may be indicated to promote or improve daytime sleep among night shift workers (Guideline) and to treat jet lag-induced insomnia (Option). Stimulants may be indicated to improve alertness in JLD and SWD (Option) but may have risks that must be weighed prior to use. Modafinil may be indicated to improve alertness during the night shift for patients with SWD (Guideline). Citation: Morgenthaler TI; Lee-Chiong T; Alessi C; Friedman L; Aurora N; Boehlecke B; Brown T; Chesson AL; Kapur V; Maganti R; Owens J; Pancer J; Swick TJ; Zak R; Standards of Practice Committee of the AASM. Practice Parameters for the Clinical Evaluation and Treatment of Circadian Rhythm Sleep Disorders. SLEEP 2007;30(11):1445-1459. PMID:18041479

  19. Exupéry - a mobile fast response system for managing a volcanic crisis

    NASA Astrophysics Data System (ADS)

    Hort, M. K.

    2009-12-01

    analyze the incoming data (e.g. earthquake classification, rapid moment tensor inversion, deformation modeling, an automatic alert level system) which are currently under development. Exupery Working Group: Barsch R (2); Bernsdorf S (3); Beyreuther M (2); Cong X (4); Dahm T (1); Eineder M (4); Erbertseder T (4); Gerstenecker C (5); Hammer C (6); Hansteen T (7); Krieger L (1); Läufer G (5); Maerker C (4); Montalvo Garcia A (1); Ohrnberger M (6); Rix M (4); Rödelsperger S (5); Seidenberger K (4); Shirzaei M (8); Stammler K (9); Stittgen H (9); Valks P (4); Walter T (8); Wallenstein N (10); Wassermann J (2); Zakšek K (1) (1)Institute of Geophysics, Hamburg, Germany; (2) Department of Earth and Environmental Sciences, Geophysical Observatory, Munich, Germany; (3)Centauron - geosoftware & consulting, Weimar, Germany; (4)DLR Oberpfaffenhofen, Germany; (5)Institute of Physical Geodesy, Darmstadt, Germany; (6)Institute of Geosciences, Potsdam, Germany; (7) IFM-GEOMAR, Leibniz Institute of Marine Sciences, Germany; (8)Department physics of the earth, GFZ, Potsdam, Germany; (9)BGR, Geocentre Hannover, Germany; (10)CVARG, Universidade Dos Acores; Portugal

  20. Soil Aeration deficiencies in urban sites

    NASA Astrophysics Data System (ADS)

    Weltecke, Katharina; Gaertig, Thorsten

    2010-05-01

    root density and tree vigour on urban soils. For that purpose gas diffusivity, soil CO2 concentrations and fine root density were measured on typical urban sites in the German cities of Göttingen, Mannheim, and Kassel. The known characteristics of soil aeration on forest sites could be affirmed for urban soils. A negative correlation was found between gas diffusion coefficients and CO2 concentration as well as between fine root extension and CO2 concentration. Changes in crown structure of beech indicating a loss of vigour were found at sites with disturbed aeration. Diffusivity patterns and CO2 concentrations of different specific urban soil sealing types were found. On more natural sites (mulch, grass) increased gas diffusion and low CO2 concentration were present. In contrast, on more compacted or sealed areas (asphalt, paving stone, macadamised road surface) the exchange between soil air and atmosphere was nearly disconnected and soil CO2 concentrations partly exceeded the known critical value of 0.6 % up to tenfold. Literature Burton, A. J.; Pregitzer, K. S.; Zogg, G. P. und Zak D. R. (1997): Effect of measurement CO2 concentrations on sugar maple root respiration. In: Canadian journal of Forest Research, H. 17, S. 421-427. Gaertig, T. (2001): Bodengashaushalt, Feinwurzeln und Vitalität von Eichen. In: Freiburger Bodenkundliche Abhandlungen, H. 40, S. 157. Qi, J.; Marshall, J. D.; Mattson, K. G. (1994): High soil carbon dioxide concentrations inhibit root respiration of Douglas fir. In: New Phytol., Jg. 128, H. 3, S. 435-442. Schack-Kirchner, H.; Gaertig, T.; Wilpert, K. v.; Hildebrand, E. E. (2001): A modified McIntyre and Phillip approach to measure top-soil gas diffusivity in-situ. In: J. Plant Nutr. Soil Sci., Jg. 164, S. 253-258.

  1. Cosmic Lens Reveals Distant Galactic Violence

    NASA Astrophysics Data System (ADS)

    2008-10-01

    By cleverly unraveling the workings of a natural cosmic lens, astronomers have gained a rare glimpse of the violent assembly of a young galaxy in the early Universe. Their new picture suggests that the galaxy has collided with another, feeding a supermassive black hole and triggering a tremendous burst of star formation. Gravitational Lens Diagram Imaging a Distant Galaxy Using a Gravitational Lens CREDIT: Bill Saxton, NRAO/AUI/NSF Click on image for details and more graphics. The astronomers used the National Science Foundation's Very Large Array (VLA) radio telescope to look at a galaxy more than 12 billion light-years from Earth, seen as it was when the Universe was only about 15 percent of its current age. Between this galaxy and Earth lies another distant galaxy, so perfectly aligned along the line of sight that its gravity bends the light and radio waves from the farther object into a circle, or "Einstein Ring." This gravitational lens made it possible for the scientists to learn details of the young, distant galaxy that would have been unobtainable otherwise. "Nature provided us with a magnifying glass to peer into the workings of a nascent galaxy, providing an exciting look at the violent, messy process of building galaxies in the early history of the Universe," said Dominik Riechers, who led this project at the Max Planck Institute for Astronomy in Germany and now is a Hubble Fellow at the California Institute of Technology (Caltech). The new picture of the distant galaxy, dubbed PSS J2322+1944, shows a massive reservoir of gas, 16,000 light-years in diameter, that contains the raw material for building new stars. A supermassive black hole is voraciously eating material, and new stars are being born at the rate of nearly 700 Suns per year. By comparison, our Milky Way Galaxy produces the equivalent of about 3-4 Suns per year. The black hole appears to be near the edge, rather than at the center, of the giant gas reservoir, indicating, the astronomers say

  2. High velocity collisions - probing the edge of planetesimal growth

    NASA Astrophysics Data System (ADS)

    Teiser, J.; Wurm, G.

    2008-09-01

    field damage around the direct impact site. This near field damage can range from a thin circular trench around the sticking projectile material to a crater which also includes the impact site as material loss. Figure 1 gives an example for a collision with near field damage leading to mass loss. The balance between these two processes determines the mass balance of a collision. (3) When the impact energies are too high a large area of the target surface can be eroded away. This far field damage depends on the target size and thus is not important for realistic conditions. Due to the size dependance of the balance between near and far field damage small projectiles can lead to a net growth even with high velocities. Conclusions Based on experimental results we present a growth model which can be a solution to the question how planetesimal growth is possible once dust aggregates are compact and velocities tend to be destructive. Projectiles of a few mm in size hit a larger aggregate with a size of ~30 cm and leave a crater in the target surface which leads to a slight mass loss. In this colision the projectiles fragment into smaller pieces whereas the target mass hardly changes. In processes of this kind a large amount of sub-mm particles is formed which can lead to a mass gain in a following collisions. Although fragmentation plays a significant role in the high velocity range planetesimal growth via mutual collisions is possible. References [1] Blum, J. and Wurm, G. (2008) ARAA, in press. [2] Dominik, C. and Tielens, A. G. G. M. (1997) ApJ,480, 647-673. [3] Weidenschilling, S. J. and Cuzzi, J. N. (1993) in Levy, E. H. and Lunine, J. I., Protostars and Planets III, 1031-1060. [4] Blum, J. and Münch, (1993) Icarus, 106, 98-116. [5] Wurm, G. et al. (2005) Icarus, 178, 253-263.

  3. PAHs in circumstellar disks around T Tauri stars

    NASA Astrophysics Data System (ADS)

    Geers, Vincent C.; Augereau, Jean-Charles; Pontoppidan, Klaus M.; Dullemond, Cornelis P.; Visser, Ruud; van Dishoeck, Ewine F.; C2d Irs Team

    3D axi-symmetric radiative transfer models of circumstellar disks (Dullemond & Dominik 2004), to study the relation between disk structure and PAH feature strength. In this poster we present our first Spitzer spectra of PAH features in T Tauri stars and first results from the PAHs in disks modeling.

  4. Coming Home at Paranal

    NASA Astrophysics Data System (ADS)

    2002-02-01

    , won by Auer and Weber Freie Architekten from Munich (Germany), and with Dominik Schenkirz as principal designer. The interior furnishing and decoration was awarded to the Chilean architect Paula Gutierrez . The construction began in late 1998. Information about this work and several photos illustrating the progress have been published as PR Photos 31a-d/99 , PR Photo 43h/99 and PR Photos 04b-d/01 . Taking advantage of an existing depression in the ground, the architects created a unique subterranean construction with a single facade opening towards the Pacific Ocean , far below at a distance of about 12 km. It has the same colour as the desert and blends perfectly into the surroundings. The Paranal Residencia is elegant, with robust and inexpensive materials. Natural daylight is brought into the building through a 35-m wide glass-covered dome, a rectangular courtyard roof and various skylight hatches. The great originality of this design has made it possible to create an interior with a feeling of open space, despite the underground location. Some building characteristics are indicated below Facilities at the Residencia To the visitor who arrives at the Paranal Residencia from the harsh natural environment, the welcoming feeling under the dome is unexpected and instantly pleasant. This is a true "oasis" within coloured concrete walls and the air is agreeably warm and moist. There is a strong sense of calm and serenity and, above all, a feeling of coming home . At night, the lighting below the roofing closure fabric is spectacular and the impression on the mind is overwhelming. The various facilities are integrated over four floors below ground level. They include small, but nice and simple bedrooms, offices, meeting points, a restaurant, a library, a reception area, a cinema and other recreational areas. The natural focal point is located next to the reception at the entrance. The dining room articulates the building at the -2 level and view points through the facade

  5. It's Far, It's Small, It's Cool: It's an Icy Exoplanet!

    NASA Astrophysics Data System (ADS)

    2006-01-01

    gravitational microlensing" by J.-P. Beaulieu, D. P. Bennett, P. Fouqué, A. Williams, M. Dominik, U. G. Jørgensen, D. Kubas et al.). High resolution images and their captions are available on this page. This press release is also accompanied by Broadcast quality material.

  6. The Application of Modern Techniques and Measurement Devices for Identification of Copper Ore Types and Their Properties / Wykorzystanie nowoczesnych technik i urządzeń pomiarowych do identyfikacji typów rud miedzi i ich właściwości

    NASA Astrophysics Data System (ADS)

    Krawczykowska, Aldona; Trybalski, Kazimierz; Krawczykowski, Damian

    2013-06-01

    The paper concerns the application of modern methods and research techniques for investigations of copper ore properties. It presents the procedure and tools which, when put together, can constitute a source of information on properties of different products of processing and, simultaneously, can be used in the process control and optimization. The copper ore of one of the branches of the KHGM Polska Miedz plc was investigated. The ore samples represented each of the three lithological types occurring in the Polish deposits, i.e. carbonate, shale and sandstone ores. The paper presents the results of microscopic analyses, image analysis of scanning photographs and application procedures of the obtained information for the identification of ore types (application of neuron networks to the recognition of lithological compositions). The present publication will present sample results of modelling of classification identifying two types of ores, i.e. carbonate-shale and sandstone. Summing up the predictions of ore type fractions in respective mixtures for the considered problem of classification it can be stated that the prediction results are good and confirm the lithological predominance of certain ore types in the investigated mixtures. The experimental part comprised the determination of mineralogical and lithological composition of ores (optical microscope) and also elemental composition in the microareas of analysed samples (scanning microscope). Next, the image analysis was performed and subsequently the models classifying the ore types were made. W rudzie miedzi przerabianej w zakładach wzbogacania O/ZWR KGHM Polska Miedź S.A. można wyróżnić trzy typy litologiczne: rudę węglanową, łupkową i piaskowcową. Typy te różnią się właściwościami między innymi takimi jak: rodzaj i zawartość minerałów miedzi, rodzaj minerałów nieużytecznych, zawartość miedzi, twardość i podatność na rozdrabnianie, ale także wielkością i kształtem ziaren

  7. Methodology of Calculation the Terminal Settling Velocity Distribution of Spherical Particles for High Values of the Reynold's Number

    NASA Astrophysics Data System (ADS)

    Surowiak, Agnieszka; Brożek, Marian

    2014-03-01

    e jest funkcją dwóch cech prostych, którymi są: wielkość ziarna i gęstość ziarna. Przynależność do określonego podzbioru ziaren jest określona przez wartość dwóch cech, a rozkład tych cech w próbce jest funkcją rozkładów gęstości i wielkości ziarna. Znajomość rozkładu prędkości opadania ziaren w osadzarce jest istotnym parametrem jak znajomość rozkładu wielkości ziarna w procesie przesiewania czy znajomość rozkładu gęstości w procesie wzbogacania w cieczach ciężkich. W artykule przedstawiono metodykę wyliczania rozkładu prędkości opadania ziaren sferycznych w warunkach ruchu turbulentnego wyrażonego przy pomocy równania Newtona. Zarówno gęstość jak i wielkość ziarna są zmiennymi losowymi o określonych rozkładach. W związku z tym prędkość opadania ziarna jako funkcja cech prostych tj. gęstości i wielkości ziarna będzie również zmienną losową o rozkładzie, który jest funkcją rozkładów argumentów prostych. Wykorzystując twierdzenia rachunku prawdopodobieństwa odnoszące się do rozkładów funkcji zmiennych losowych przedstawiono ogólny wzór na funkcję gęstości rozkładu prędkości opadania w warunkach ruchu turbulentnego. Empiryczne rozkłady wielkości i gęstości ziaren aproksymowano rozkładem Weibulla. Rozkład prędkości opadania wyliczono numerycznie i przedstawiono w postaci graficznej. W artykule przedstawiono symulację wyliczania rozkładu prędkości opadania w oparciu o rzeczywiste rozkłady gęstości i średnicy projekcyjnej ziaren zakładając, że ziarna mają kształt sferyczny.

  8. New gravity control in Poland - needs, the concept and the design

    NASA Astrophysics Data System (ADS)

    Krynski, Jan; Olszak, Tomasz; Barlik, Marcin; Dykowski, Przemyslaw

    2013-06-01

    transformation to a new system (as 2nd order network) as well as a definition of gravity system as "zero-tide" system. Seasonal variability of gravity has been discussed indicating that the effects of environmental changes when establishing modern gravity control with absolute gravity survey cannot be totally neglected. Założona w Polsce w ostatniej dekadzie XX wieku zgodnie z obowiązującymi standardami międzynarodowymi Podstawowa Osnowa Grawimetryczna Kraju (POGK), składająca się z około 350 punktów, została oparta na 12 absolutnych punktach grawimetrycznych, na których przyspieszenie siły ciężkości wyznaczono przy użyciu czterech różnych typów grawimetrów absolutnych. Względne pomiary grawimetryczne na punktach tej osnowy, z jednoczesnym dowiązaniem jej do przyspieszenia siły ciężkości na 12 absolutnych punktach grawimetrycznych, wykonały różne grupy pomiarowe przy wykorzystaniu grawimetrów LaCoste&Romberg (LCR). Konstrukcja powstałej sieci grawimetrycznej, w szczególności ograniczona liczba nierównomiernie rozłożonych punktów absolutnych na terenie kraju, na których w dodatku przyspieszenie siły ciężkości wyznaczono różnymi instrumentami w różnych epokach, spowodowały wystąpienie błędów systematycznych w wartościach g na punktach POGK. W niniejszej pracy, przy wykorzystaniu pomiarów grawimetrycznych wykonanych w latach 2007-2008 dokonano oceny tych błędów oraz przeprowadzono dyskusję ich możliwych źródeł. Rozwój technologii absolutnych pomiarów grawimetrycznych, w szczególności instrumentów przeznaczonych do precyzyjnych absolutnych pomiarów grawimetrycznych w warunkach polowych, stwarza możliwość założenia nowego typu osnowy grawimetrycznej, składającej się ze stacji, na których przyspieszenie siły ciężkości jest pomierzone grawimetrami absolutnymi. Nowa osnowa grawimetryczna Polski, która będzie zakładana w latach 2012-2014, będzie się składała z 28 punktów fundamentalnych (mierzonych

  9. Trading forests for yields in the Peruvian Amazon

    NASA Astrophysics Data System (ADS)

    Gibbs, Holly

    2012-03-01

    inhabited and often have contested land tenure. We must carefully consider our consumption of these commodities in the face of growing land scarcity (Lambin and Meyfroidt 2011). If high-yield plantations displace low-yield plantations they too may follow the path of industrial agriculture and resume destruction of the forests that conservation efforts aim to protect. Without clear incentives to spare land, we could be trading forest for higher yields. References Angelsen A and Kaimowitz D 2001 Agricultural Technologies and Tropical Deforestation (New York: CABI Publishing) (www.cifor.org/publications/pdf files/books/bangelsen0101e0.pdf) Butler R and Laurance W 2010 Is oil palm the next emerging threat to the Amazon? Trop. Conserv. Sci. 2 1-10 Gibbs H K, Johnston M, Foley J A, Holloway T, Monfreda C, Ramankutty N and Zaks D 2008 Carbon payback times for crop-based biofuel expansion in the tropics: the effects of changing yield and technology Environ. Res. Lett. 3 034001 Gibbs H K, Ruesch A S, Achard F, Clayton M K, Holmgren P, Ramankutty N and Foley J A 2010 Tropical forests were the primary sources of new agricultural land in the 1980s and 1990s Proc. Natl Acad. Sci. 107 16732-7 Gutiérrez-Vélez V H, DeFries R, Pinedo-Vásquez M, Uriarte M, Padoch C, Baethgen W, Fernandes K and Lim Y 2011 High-yield oil palm expansion spares land at the expense of forests in the Peruvian Amazon Environ. Res. Lett. 6 044029 Koh L and Wilcove D 2008 Is oil palm agriculture really destroying tropical biodiversity? Conserv. Lett. 1 60-4 Lambin E and Meyfroidt P 2011 Inaugural article: global land use change, economic globalization, and the looming land scarcity Proc. Natl Acad. Sci. 108 93465-72 Morton D C et al 2006 Cropland expansion changes deforestation dynamics in the southern Brazilian Amazon Proc. Natl Acad. Sci. USA 103 14637-41

  10. Determining Acceptable Explosive Charge Mass Under Different Geological Conditions / Problematyka Wyznaczania Dopuszczalnych Ładunków Mw W Zróżnicowanych Warunkach Geologicznych

    NASA Astrophysics Data System (ADS)

    Pyra, Józef; Sołtys, Anna; Winzer, Jan; Dworzak, Michał; Biessikirski, Andrzej

    2015-09-01

    This article presents a procedure for determining the safety of explosive charges for their surrounding environment, using a limestone mine as a case study. Varied geological structures, as well as other constructions in the surrounding area of a mine, sometimes necessitate the use of two or more ground vibration propagation equations, and thus a variety of explosive charges, depending on the area of rock blasting. This is a crucial issue for the contractor, as it is important to blast the rock as few times as possible, while using the maximum amount of explosive charge for each blast. Wykonywanie robót strzałowych w górnictwie polega na odpalaniu mas materiału wybuchowego (MW) celem uzyskania dużej ilości odpowiednio rozdrobnionego urobku. W momencie zwiększonego popytu na surowce skalne zakłady górnicze zmuszone są do zwielokrotnienia wykonywania prac strzałowych aby zapewnić regularne dostawy produktu. Konsekwencją takich działań jest ponoszenie dodatkowych kosztów operacyjnych. Celem ich minimalizacji oraz uzyskania jak największej efektywności prowadzonych robót strzałowych jest wydłużanie serii, a więc stosowanie coraz to większych mas ładunków materiałów wybuchowych. Efektem takiego postępowanie jest możliwość wystąpienia w otoczeniu oddziaływania o potencjalnie szkodliwym charakterze m. in. drgania parasejsmiczne. Aby wyeliminować powyższy problem oraz zapewnić niezbędny komfort mieszkańcom, Prawo geologiczne i górnicze, Prawo ochrony środowiska i rozporządzenia wykonawcze nakładają na podmiot wykonujący roboty strzałowe obowiązek ochrony otoczenia, poprzez prowadzenie działalności profilaktycznej w zakresie kontroli, monitorowania oraz wyznaczania dopuszczalnych mas ładunków MW. W momencie gdy nie ma możliwości ograniczenia niepożądanych wpływów dynamicznych po przez zmianę parametrów siatki strzałowej czy modyfikację struktury czasowo-częstotliwościowej drgań, jedyną możliwością staje si

  11. Modelling of Underground Coal Gasification Process Using CFD Methods / Modelowanie Procesu Podziemnego Zgazowania Węgla Kamiennego Z Zastosowaniem Metod CFD

    NASA Astrophysics Data System (ADS)

    Wachowicz, Jan; Łączny, Jacek Marian; Iwaszenko, Sebastian; Janoszek, Tomasz; Cempa-Balewicz, Magdalena

    2015-09-01

    ł transportu energii cieplnej. Warstwę węgla oraz warstwy geologiczne otaczające georeaktor traktuje się jako ciało jednorodne. Badania modelowe zakładały prowadzenie procesu zgazowania calizny węglowej przy udziale, osobno tlenu i powietrza, jako czynnika zgazowującego, w warunkach ustalonych pracy georeaktora w przedziale czasu 100 godzin i 305 godzin. Uzyskane wyniki rozwiązania numerycznego zestawiono z wynikami badań eksperymentalnych w warunkach in-situ.

  12. Determination of Critical Conditions of Spontaneous Combustion of Coal in Longwall Gob Areas / Wyznaczanie Warunków Krytycznych Samozapalania Węgla W Zrobach Ścian

    NASA Astrophysics Data System (ADS)

    Cygankiewicz, Janusz

    2015-09-01

    pożaru niektórych warunków panujących w danym miejscu kopalni, takich jak: - skłonność węgla do samozapalania - zawartość tlenu w powietrzu dopływającym do zagrzewającego się węgla. W pracy przedstawiono numeryczną metodę wyznaczania warunków krytycznych samozapalania węgla w zrobach ścian, czyli takich po spełnieniu których może dojść do samozapalenia. Przyjęto, że znajdujący się w zrobach rozkruszony węgiel ma kształt płaskiej warstwy, sąsiadującej od stropu i spągu ze skałami. Rozważania ograniczono do węgli charakteryzujących się niską zawartością wilgoci. Przyjęto prosty model kinetyki utleniania na powierzchni węgla wyrażony równaniem Arrheniusa. Model ten zakłada niezależność szybkości utleniania od ilości tlenu pochłoniętego przez węgiel. Szybkość reakcji zależy jedynie od temperatury , przy czym występujące w równaniu parametry zmieniają się po osiągnięciu przez węgiel temperatury krytycznej. W artykule przedstawiono matematyczny model samozagrzewania warstwy węgla w zrobach opisujący bilans ciepła w węglu oraz bilans tlenu i bilans ciepła w przepływających gazach. Tworzące model układy równań różniczkowych cząstkowych rozwiązywane są metodami numerycznymi. Opracowany program komputerowy umożliwia wykonywanie stosownych obliczeń. W pracy, na przykładzie węgla z pokładu 405 , przedstawiono sposób wyznaczania warunków krytycznych warstwy rozkruszonego węgla: grubości warstwy, zawartości tlenu w przepływających przez warstwę gazach oraz przewodności cieplnej otaczających skał.

  13. Waterproof Anti-Explosive Powders for Coal Mines

    NASA Astrophysics Data System (ADS)

    Buczek, Bronisław; Vogt, Elżbieta

    2014-03-01

    properties not only as a water resistant material but also from the cohesion point of view. On the base of TG, DTG or DTA and EGA curves for all investigated materials was stated that the character of the thermal decomposition of modified samples is the same as this one for raw powder, what is profitable for application of hydrophobized powders as an anti-explosive agent. W górnictwie węgla kamiennego używany jest hydrofobowy pył wapienny jako substancja stosowana w systemie zabezpieczeń przeciwwybuchowych (Cybulski, 2004). Niestety, dotychczasowy sposób wy- twarzania takiego produktu polegający na współmieleniu kamienia wapiennego z kwasem stearynowym staje się praktycznie niemożliwy do stosowania w nowoczesnych zakładach np. kamieniołomy. Sytuacja taka jest wynikiem wprowadzania zmian technologicznych, głównie związanych z wymianą starych konstrukcji młynów na nowe urządzenia. Tym samym istnieje potrzeba poszukiwania nowych metod hydrofobizacji powierzchni pyłów wapiennych. W pracy omówiono dwie nowe metody hydrofobizacji pyłu wapiennego: za pomocą par kwasu stearynowego oraz roztworu silikonowego - Sarsil® H-15. Podczas badań używano surowego pyłu wapiennego pochodzącego z Kopalni Kamienia Wapiennego w Czatkowicach. Materiał ten jest dobrym materiałem do badań gdyż istnieje możliwość porównywania właściwości materiałów hydrofobowych otrzymanych w pracy z właściwościami handlowego pyłu przeciwwybuchowego (Polska Norma, 1994), używanego w polskich kopalniach. Pierwszy sposób hydrofobizacji pyłu wapiennego, polegający na swobodnym opadaniu pyłu wapiennego w oparach kwasu stearynowego przepływających w przeciwprądzie, przeprowadzono w aparacie własnej konstrukcji (Vogt, 2008, 2011). Aparat gwarantuje dobry kontakt modyfikatora z ziarnami pyłu. Pył opadając, nie napotyka żadnych przeszkód ulegał rozproszeniu, a wprowadzony w stanie parowym kwas stearynowy może swobodnie osiadać na jego powierzchni zewn

  14. Unique Project of Single-Cutting Head Longwall Shearer Used for Thin Coal Seams Exploitation / Projekt Jednoorganowego Kombajnu ŚCIANOWEGO O Specjalnej Konstrukcji Przeznaczonego do Eksploatacji POKŁADÓW Cienkich

    NASA Astrophysics Data System (ADS)

    Bołoz, Łukasz

    2013-12-01

    żowe zamiast płatów), aby powstający podczas frezowania urobek mógł spadać na spąg (Krauze, 2012b). Przykładowe rozwiązanie organu przestrzennego przedstawia fig. 3. Funkcję ładowania, realizowaną normalnie przez płaty, przejmują ładowarki. Rozdzielenie procesu ładowania od procesu frezowania jest jedną z najważniejszych zalet prezentowanego rozwiązania. Podczas pracy w ścianie parametry kinematyczne kombajnu mogą być zwiększane bez ryzyka wystąpienia problemów z ładowaniem na przenośnik, co obok możliwości ruchowych kombajnisty było głównym czynnikiem hamującym wzrost wydobycia. Załadunek urobku na przenośnik odbywa się za pomocą ładowarki, która po zmianie kierunku urabiania składa się, natomiast druga ustawiana jest w pozycji roboczej (Krauze, 2010). Kombajn porusza się tradycyjnie po rynnie przenośnika, jednak przy zastosowaniu cięgnowego systemu posuwu, który zrealizowany jest za pomocą napędów znajdujących się w chodnikach. Rozwiązanie takie umożliwia znaczne zmniejszenie gabarytów kombajnu dzięki usunięciu ciągników z kadłuba. Należy zaznaczyć, że w prezentowanym rozwiązaniu zakłada się zastosowanie pełnej automatyzacja pracy kombajnu i pozostałych maszyn ścianowych, co pozwala na urabianie calizny bez obecności załogi bezpośrednio w wyrobisku. Ma to duże znaczenie dla możliwości zwiększenia prędkości posuwu, szczególnie przy zakresie wysokości 1.0 m÷1.6 m. Przy wykorzystaniu znanych, z rozwiązań strugowych, systemów automatyki, sterowania i diagnostyki wprowadzenie automatyzacji procesu nie będzie stanowiło znaczącego problemu. W proponowanym rozwiązaniu kombajn ma możliwość wyjechania do chodnika na tyle, aby możliwe było zrealizowanie przekładki jak w przypadku strugów. Uzyskuje się wtedy krótki czas przekładki, który w skrajnym przypadku może zmieścić się w tzw. czasie organizacyjnym ściany. Ponadto urabianie odbywa się pełnym zabiorem na całej długości

  15. Geotechnical Aspects of Revitalisation of Post-Mining Areas - An Example of the Adaptation of Katowice Hard Coal Mine for the New Silesian Museum / Geotechniczne aspekty rewitalizacji terenów pogórniczych - przykład adaptacji KWK "KATOWICE" na nowe muzeum śląskie

    NASA Astrophysics Data System (ADS)

    Cała, Marek; Ostręga, Anna

    2013-06-01

    The article presents the history of the Katowice Hard Coal Mine and the concept of revitalisation taking into consideration the historical development of the mine which today is closed. The concept accepted for realisation assumes adaptation of the post-mining area with its historical infrastructure for cultural functions, and namely for the construction of the New Silesian Museum. Basing the concept on the idea of minimum interference into the existing spatial layout of the former mine has had the result that the museum areas and garages have been designed under the surface of the area adjacent to the historic facilities of the mine. In relation therewith, it was necessary to carry out the works aimed at reinforcing foundations of the historic buildings and protecting the geotechnical pit slopes. The article presents the technological solutions applied to protect the historic buildings, the lift tower, and the excavations for new facilities of the Silesian Museum. Attention was drawn to the instability of the subsoil and of the rock mass due to previous mining operations conducted in the area, the need to adapt the protection technology to the existing conditions as well as the need of constant monitoring of geotechnical works underway.> It is emphasised that the presented investment is part of an ongoing process aimed at preserving the industrial part of the material cultural heritage of Upper Silesia, for centuries connected with hard coal mining and as such it stands a chance to become a showcase not only for Katowice but for the entire region of Silesia. W artykule przedstawiono historię Kopalni Węgla Kamiennego "Katowice" oraz koncepcję rewitalizacji uwzględniającą historyczną zabudowę nieczynnej już dziś kopalni. Przyjęta do realizacji koncepcja zakłada przystosowanie pogórniczego terenu wraz z zabytkową infrastrukturą dla funkcji kulturowych, a mianowicie budowy Nowego Muzeum Śląskiego. Siedziba Nowego Muzeum Śląskiego lokalizowana jest w

  16. VLT Spectra "Resolve" a Stellar Disk at 25,000 Light-Years Distance

    NASA Astrophysics Data System (ADS)

    2001-04-01

    " ) that appeared in the April 1, 2001 issue of the "Astrophysical Journal" (available on the web at ApJL 550, L173 or astro-ph0011380). Notes [1] Note the recent ESO Press Release 06/01 about the VLT Interferometer. Observations of binary stars that undergo eclipses from time to time also allow indirect studies of the surfaces of the two components; such objects, however, influence each other and cannot be characterized as "normal" stars. [2] The team (the PLANET collaboration) consists of Michael Albrow , Kailash C. Sahu (Space Telescope Science Institute, Baltimore, MD, USA) Jin H. An (Dept. of Astronomy, Ohio State University, Columbus, OH, USA), Jean-Philippe Beaulieu (Institut d'Astrophysique de Paris, France), John A. R. Caldwell , John W. Menzies , Pierre Vermaak (South African Astronomical Observatory, Cape Town, South Africa), Martin Dominik , Penny D. Sackett (Kapteyn Astronomical Institute, Groningen, The Netherlands) , John Greenhill , Kym Hill , Stephen Kane , Robert Watson (University of Tasmania, Hobart, Tasmania, Australia), Ralph Martin , Andrew Williams (Perth Observatory, Australia), Karen Pollard (Physics Dept., Gettysburg College, PA, USA) and Peter H. Hauschildt (Dept. of Physics and Astronomy & Center for Simulational Physics, University of Georgia, Athens, GA, USA). [3] The distance to the Sun is 149.6 million kilometres; 25,000 light-years = 240,000,000,000,000,000 kilometres. 1 billion = 1000 million. [4] The diameter of the cool giant star is approx. 15 million km (about ten times that of the Sun). At the indicated distance, 25,000 light-years, this corresponds to a very small angle, about 10 micro-arcsec. This is equal to the angle subtended by a human hair (diameter 50 microns = 0.05 mm) at a distance of 1000 km. Technical information about the photos PR Photo 16b/01 shows a 0.25-sec acquisition exposure of EROS-BLG-2000-5 , obtained with VLT ANTU + FORS1 in order to set up the spectrograph slit for the subsequent spectral exposures. The