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Sample records for don frente al

  1. Don Graves Remembered

    ERIC Educational Resources Information Center

    Romano, Tom

    2011-01-01

    Don Graves died Tuesday, September 28, 2010. In the early 1980s, Don blew open the door to teaching children to write. His qualitative research and subsequent 26 books transformed the teaching of writing in elementary schools. He showed how much could be learned by the simple, powerful strategy of sitting beside children and asking them about…

  2. AERIAL VIEW, LOOKING SOUTH WEST, BIRMINGPORT ROAD AND DON DRENNEN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AERIAL VIEW, LOOKING SOUTH WEST, BIRMINGPORT ROAD AND DON DRENNEN OVERPASS IN FOREGROUND, TCI-US STEEL ENSLEY WORKS OPEN HEARTH (RUINS) IN THE BACKGROUND. - Tennessee Coal & Iron Company, Ensley Works, West of residential & commercial districts, Birmingham, Jefferson County, AL

  3. AERIAL VIEW, LOOKING SOUTH WEST, BIRMINGHAM PORT ROAD DON DRENNAN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AERIAL VIEW, LOOKING SOUTH WEST, BIRMINGHAM PORT ROAD DON DRENNAN OVERPASS IN FOREGROUND, TCI-US STEEL ENSLEY WORKS IN THE BACKGROUND. - Tennessee Coal & Iron Company, Ensley Works, West of residential & commercial districts, Birmingham, Jefferson County, AL

  4. Tropical Storm Don

    NASA Image and Video Library

    GOES-13 data was compiled into an animation by the NASA GOES Project at NASA Goddard that shows the development of Tropical Storm Don in the southern Gulf of Mexico, west of Cuba. The animation run...

  5. Don Quixote. [Lesson Plan].

    ERIC Educational Resources Information Center

    Rooks, Kristen

    Based on Miguel de Cervantes' novel "Don Quixote," this lesson plan presents activities designed to help students understand that Quixote's misperceptions are understandable; writers often describe one object to sound as if it were something else; and metaphors help readers see with new eyes. The main activity of the lesson involves students…

  6. Don Eddy; "Jewelry."

    ERIC Educational Resources Information Center

    Schaefer, Claire

    1989-01-01

    Presents a lesson that introduces students in grades K-three to sources of design inspiration in contemporary urban settings. Using Don Eddy's painting of a jewelry store window display, asks students to describe and analyze the interplay of shape, pattern, and color. Suggests studio activities, including an activity in which students build a…

  7. Neurology and Don Quixote.

    PubMed

    Palma, Jose-Alberto; Palma, Fermin

    2012-01-01

    Don Quixote de la Mancha, which is considered one of the most important and influential works of Western modern prose, contains many references of interest for almost all of the medical specialties. In this regard, numerous references to neurology can be found in Cervantes' immortal work. In this study, we aimed to read Don Quixote from a neurologist's point of view, describing the neurological phenomena scattered throughout the novel, including tremors, sleep disturbances, neuropsychiatric symptoms, dementia, epilepsy, paralysis, stroke, syncope, traumatic head injury, and headache; we relate these symptoms with depictions of those conditions in the medical literature of the time. We also review Cervantes' sources of neurological information, including the works by renowned Spanish authors such as Juan Huarte de San Juan, Dionisio Daza Chacón and Juan Valverde de Amusco, and we hypothesize that Don Quixote's disorder was actually a neurological condition. Although Cervantes wrote it four centuries ago, Don Quixote contains plenty of references to neurology, and many of the ideas and concepts reflected in it are still of interest. Copyright © 2012 S. Karger AG, Basel.

  8. Studies on the Bioavailability of Deoxynivalenol (DON) and DON Sulfonate (DONS) 1, 2, and 3 in Pigs Fed with Sodium Sulfite-Treated DON-Contaminated Maize

    PubMed Central

    Paulick, Marleen; Winkler, Janine; Kersten, Susanne; Schatzmayr, Dian; Schwartz-Zimmermann, Heidi Elisabeth; Dänicke, Sven

    2015-01-01

    Deoxynivalenol (DON) exposure of pigs might cause serious problems when critical dietary toxin concentrations are exceeded. As DON contamination of agricultural crops cannot be completely prevented, detoxification measures are needed. Wet preservation with sodium sulfite resulted in a significant DON reduction of naturally-contaminated maize in previous experiments. The preserved material had a characteristic DON sulfonates (DONS) pattern. DONS is known to be less toxic than DON but its stability was shown to depend on pH, which gives rise to the question if a back-conversion to DON occurs in vivo. Therefore, the toxicokinetics and bioavailability of DON and DONS were studied in pigs. After the administration of a single oral or intravenous bolus of DON or DONS, serial blood samples were collected and subsequently analyzed. DONS was not detectable after oral administration of DONS mixtures. The results showed further that the bioavailability of DONS as DON in pigs fed maize preserved wet with sodium sulfite was significantly decreased compared to untreated control maize (DON), indicating that DONS obviously did not convert back to DON to a large extent in vivo. Moreover, the fact that DONS was not detectable in systemic blood requires further investigations regarding their ingestive and/or metabolic fate. PMID:26556376

  9. Studies on the bioavailability of deoxynivalenol (DON) and DON sulfonate (DONS) 1, 2, and 3 in pigs fed with sodium sulfite-treated DON-contaminated maize.

    PubMed

    Paulick, Marleen; Winkler, Janine; Kersten, Susanne; Schatzmayr, Dian; Schwartz-Zimmermann, Heidi Elisabeth; Dänicke, Sven

    2015-11-05

    Deoxynivalenol (DON) exposure of pigs might cause serious problems when critical dietary toxin concentrations are exceeded. As DON contamination of agricultural crops cannot be completely prevented, detoxification measures are needed. Wet preservation with sodium sulfite resulted in a significant DON reduction of naturally-contaminated maize in previous experiments. The preserved material had a characteristic DON sulfonates (DONS) pattern. DONS is known to be less toxic than DON but its stability was shown to depend on pH, which gives rise to the question if a back-conversion to DON occurs in vivo. Therefore, the toxicokinetics and bioavailability of DON and DONS were studied in pigs. After the administration of a single oral or intravenous bolus of DON or DONS, serial blood samples were collected and subsequently analyzed. DONS was not detectable after oral administration of DONS mixtures. The results showed further that the bioavailability of DONS as DON in pigs fed maize preserved wet with sodium sulfite was significantly decreased compared to untreated control maize (DON), indicating that DONS obviously did not convert back to DON to a large extent in vivo. Moreover, the fact that DONS was not detectable in systemic blood requires further investigations regarding their ingestive and/or metabolic fate.

  10. [Al

    PubMed

    Purath; Köppe; Schnöckel

    1999-10-04

    A "naked" aluminum atom links two aluminum tetrahedra in the [Al(7){N(SiMe(3))(2)}(6)](-) ion (see picture), which results from the reaction of a metastable AlCl solution with LiN(SiMe(3))(2) and crystallizes with [Li(OEt(2))(3)](+) as cation. This unique structure among molecular metal atom clusters represents a small but characteristic section of cubic close-packed aluminum.

  11. Don't panic

    NASA Astrophysics Data System (ADS)

    Harris, Margaret

    2009-06-01

    "Don't panic" is a simple piece of advice, one that usually applies equally well to job-hunting, avoiding pandemic flu or, like the hapless Arthur Dent in the Hitchhiker's Guide to the Galaxy stories, wandering the universe in search of a decent cup of tea. Yet some statistics emerging from the current job market are undeniably alarming. Postings on the recruitment website Milkround.com, which advertises jobs and internships for recent graduates, are down by about 20% compared with this time last year, while a survey earlier this year by High Fliers, a Londonbased research firm, found that top UK employers plan to recruit 17% fewer graduates this year than in 2008. In the same study, half of the 1017 final-year students surveyed believed they would have to take "any graduate job" they were offered, regardless of their interest in the company, and a whopping 91% thought competition for vacancies would be tougher than last year.

  12. The Don'ts and Don'ts of Teaching

    ERIC Educational Resources Information Center

    Rubinstein, Gary

    2012-01-01

    Gary Rubinstein doesn't buy the adage that rules--for students or for teachers--must be stated positively, without don'ts or nots. So he lists 10 rules for things teachers must not do in their first years. Tops on his list is "Don't try to teach too much in one day," which Rubinstein says is a common mis-step because teacher preparation programs,…

  13. The Don'ts and Don'ts of Teaching

    ERIC Educational Resources Information Center

    Rubinstein, Gary

    2012-01-01

    Gary Rubinstein doesn't buy the adage that rules--for students or for teachers--must be stated positively, without don'ts or nots. So he lists 10 rules for things teachers must not do in their first years. Tops on his list is "Don't try to teach too much in one day," which Rubinstein says is a common mis-step because teacher preparation programs,…

  14. "Don't take diabetes for granted."

    MedlinePlus

    ... please turn Javascript on. Feature: Diabetes Stories "Don't take diabetes for granted." Past Issues / Fall 2009 ... regularly, and take your medicines on time. Don't take diabetes for granted! Fall 2009 Issue: Volume ...

  15. DON Mentor-Protege Program

    DTIC Science & Technology

    2011-08-23

    DON Mentor-Protégé Program August 23, 2011 Oreta Stinson Deputy Director, Department of the Navy Office of Small Business Programs Report...2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE DON Mentor-Protege Program 5a. CONTRACT NUMBER 5b. GRANT...NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS

  16. Trouble Don't Last

    ERIC Educational Resources Information Center

    Pearsall, Shelley

    2004-01-01

    Even as a child, Pearsall questioned social injustice and prejudice. In her own community in Ohio and, as she grew, all over the world, she saw social inequities she could neither understand nor accept. Her novel "Trouble Don't Last," takes place during the era of the Underground Railroad. The chapter included here pulls us in…

  17. Counseling According to don Juan

    ERIC Educational Resources Information Center

    Pulvino, Charles J.; Lee, James L.

    1975-01-01

    This article specifies a number of precepts put forth by don Juan, a Yaqui Indian sorcerer. It also outlines the consequences of each precept for counselors. The intent is to facilitate the emergence of a new reality for counseling and other helping professions. (Author/BW)

  18. Trouble Don't Last

    ERIC Educational Resources Information Center

    Pearsall, Shelley

    2004-01-01

    Even as a child, Pearsall questioned social injustice and prejudice. In her own community in Ohio and, as she grew, all over the world, she saw social inequities she could neither understand nor accept. Her novel "Trouble Don't Last," takes place during the era of the Underground Railroad. The chapter included here pulls us in…

  19. Don Quixote and Fifth Graders

    ERIC Educational Resources Information Center

    Glass, Janet L.

    2006-01-01

    This article describes how the author makes the story of "Don Quixote de la Mancha" come alive to fifth graders in her Spanish class. She rewrote several scenes from the novel into short plays that were appropriate to the students' interests and to their novice-high proficiency level. The author chose a combination of scenes that offer…

  20. Don Sharp Home Improvements Information Sheet

    EPA Pesticide Factsheets

    Don Sharp Home Improvements (the Company) is located in Bartlett, Tennessee. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Memphis, Tennessee.

  1. Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows.

    PubMed

    Schwartz-Zimmermann, Heidi E; Hametner, Christian; Nagl, Veronika; Fiby, Iris; Macheiner, Lukas; Winkler, Janine; Dänicke, Sven; Clark, Erica; Pestka, James J; Berthiller, Franz

    2017-06-21

    The Fusarium mycotoxin deoxynivalenol (DON) is a frequent contaminant of cereal-based food and feed. Mammals metabolize DON by conjugation to glucuronic acid (GlcAc), the extent and regioselectivity of which is species-dependent. So far, only DON-3-glucuronide (DON-3-GlcAc) and DON-15-GlcAc have been unequivocally identified as mammalian DON glucuronides, and DON-7-GlcAc has been proposed as further DON metabolite. In the present work, qualitative HPLC-MS/MS analysis of urine samples of animals treated with DON (rats: 2 mg/kg bw, single bolus, gavage; mice: 1 mg/kg bw, single i.p. injection; pigs: 74 µg/kg bw, single bolus, gavage; cows: 5.2 mg DON/kg dry mass, oral for 13 weeks) revealed additional DON and deepoxy-DON (DOM) glucuronides. To elucidate their structures, DON and DOM were incubated with human (HLM) and rat liver microsomes (RLM). Besides the expected DON/DOM-3- and 15-GlcAc, minor amounts of four DON- and four DOM glucuronides were formed. Isolation and enzymatic hydrolysis of four of these compounds yielded iso-DON and iso-DOM, the identities of which were eventually confirmed by NMR. Incubation of iso-DON and iso-DOM with RLM and HLM yielded two main glucuronides for each parent compound, which were isolated and identified as iso-DON/DOM-3-GlcAc and iso-DON/DOM-8-GlcAc by NMR. Iso-DON-3-GlcAc, most likely misidentified as DON-7-GlcAc in the literature, proved to be a major DON metabolite in rats and a minor metabolite in pigs. In addition, iso-DON-8-GlcAc turned out to be one of the major DON metabolites in mice. DOM-3-GlcAc was the dominant DON metabolite in urine of cows and an important DON metabolite in rat urine. Iso-DOM-3-GlcAc was detected in urine of DON-treated rats and cows. Finally, DON-8,15-hemiketal-8-glucuronide, a previously described by-product of DON-3-GlcAc production by RLM, was identified in urine of DON-exposed mice and rats. The discovery of several novel DON-derived glucuronides in animal urine requires adaptation of

  2. Don Quixote Pond Sediments: Surface and Subsurface Chemistry and Mineralogy

    NASA Astrophysics Data System (ADS)

    Englert, P. A. J.; Bishop, J. L.; Patel, S.; Gibson, E. K.; Koeberl, C.

    2014-12-01

    Don Quixote Pond, like Don Juan Pond in the South Fork of Wright Valley, Antarctica, is a model for calcium and chlorine weathering and distribution on Mars. It is located in the western part of the North Fork about 100 m above Mean Seawater Level; its brine is seasonally frozen [1]. Field observations show zones of discoloration which grow lighter with distance from the pond edges. Four sediment cores, a set of radial surface samples, special surface samples, and samples of local rocks were obtained [2]. We report on chemical and mineral analyses of traverse samples and on two cores. Core DQ20 is a northeastern shoreline core. Its soluble salt concentration exceeds 200 micromoles/g in the top 5 cm, and then falls to less than 70 micromoles/g at the permafrost depth of 15 cm. These concentrations are low when compared to similarly positioned locations at Don Juan Pond and to cores from Prospect Mesa close to Lake Vanda, Wright Valley. Halite, soda niter, tachyhydrite and/bischovite are suggested from the ionic molar relationships Measured halite concentrations of surface samples, collected along a traverse of 35 m from the pond outwards, range from over 5% to trace amounts, decreasing with distance. Gypsum is also present in almost all of these samples ranging from 0.2% to 2.6%, but does not exhibit a trend. However, in core DQ35, located at a distance of 15 m along the traverse, gypsum decreases from 2.5% to 0.6% from the surface to the permafrost depth of 12 cm. While DQ35 and radial samples show high quartz and albite abundance, samples that contained visible encrustations and evaporites are low in these minerals and rich in highly diverse alteration products. Don Juan Basin ponds may have formed by a complex surface water mobilization of weathering products [3] and local groundwater action [4,5]. In contrast, Don Quixote pond mineralogy and chemistry may be consistent with a less complex shallow and deep groundwater system origin [1]. [1] Harris H

  3. [Don Quijote, a lucid mad].

    PubMed

    Alonso Fernández, Francisco

    2004-01-01

    The case of a 50-year-old hidalgo who believed to be transformed into a knight-errant named Don Quijote is a megalomaniac systematized delusion of transformation of the self, a delusion of metamorphosis in reference to the patient's own identity. The outward projection of this syndrome produces some delusional misidentifications of others, things and animals and include elements of a persecutory delusion which increase the grandiosity of the self. At the same time the hidalgo was maniac with a pathway of bipolar disorder. The phenomenon of donquijotismo is described as the defence of wasted causes and Sancho Panza as an illiterate Sócrates.

  4. Microbial biotransformation of DON: molecular basis for reduced toxicity

    PubMed Central

    Pierron, Alix; Mimoun, Sabria; Murate, Leticia S.; Loiseau, Nicolas; Lippi, Yannick; Bracarense, Ana-Paula F. L.; Schatzmayr, Gerd; He, Jian Wei; Zhou, Ting; Moll, Wulf-Dieter; Oswald, Isabelle P.

    2016-01-01

    Bacteria are able to de-epoxidize or epimerize deoxynivalenol (DON), a mycotoxin, to deepoxy-deoxynivalenol (deepoxy-DON or DOM-1) or 3-epi-deoxynivalenol (3-epi-DON), respectively. Using different approaches, the intestinal toxicity of 3 molecules was compared and the molecular basis for the reduced toxicity investigated. In human intestinal epithelial cells, deepoxy-DON and 3-epi-DON were not cytotoxic, did not change the oxygen consumption or impair the barrier function. In intestinal explants, exposure for 4 hours to 10 μM DON induced intestinal lesions not seen in explants treated with deepoxy-DON and 3-epi-DON. A pan-genomic transcriptomic analysis was performed on intestinal explants. 747 probes, representing 323 genes, were differentially expressed, between DON-treated and control explants. By contrast, no differentially expressed genes were observed between control, deepoxy-DON and 3-epi-DON treated explants. Both DON and its biotransformation products were able to fit into the pockets of the A-site of the ribosome peptidyl transferase center. DON forms three hydrogen bonds with the A site and activates MAPKinases (mitogen-activated protein kinases). By contrast deepoxy-DON and 3-epi-DON only form two hydrogen bonds and do not activate MAPKinases. Our data demonstrate that bacterial de-epoxidation or epimerization of DON altered their interaction with the ribosome, leading to an absence of MAPKinase activation and a reduced toxicity. PMID:27381510

  5. Microbial biotransformation of DON: molecular basis for reduced toxicity

    NASA Astrophysics Data System (ADS)

    Pierron, Alix; Mimoun, Sabria; Murate, Leticia S.; Loiseau, Nicolas; Lippi, Yannick; Bracarense, Ana-Paula F. L.; Schatzmayr, Gerd; He, Jian Wei; Zhou, Ting; Moll, Wulf-Dieter; Oswald, Isabelle P.

    2016-07-01

    Bacteria are able to de-epoxidize or epimerize deoxynivalenol (DON), a mycotoxin, to deepoxy-deoxynivalenol (deepoxy-DON or DOM-1) or 3-epi-deoxynivalenol (3-epi-DON), respectively. Using different approaches, the intestinal toxicity of 3 molecules was compared and the molecular basis for the reduced toxicity investigated. In human intestinal epithelial cells, deepoxy-DON and 3-epi-DON were not cytotoxic, did not change the oxygen consumption or impair the barrier function. In intestinal explants, exposure for 4 hours to 10 μM DON induced intestinal lesions not seen in explants treated with deepoxy-DON and 3-epi-DON. A pan-genomic transcriptomic analysis was performed on intestinal explants. 747 probes, representing 323 genes, were differentially expressed, between DON-treated and control explants. By contrast, no differentially expressed genes were observed between control, deepoxy-DON and 3-epi-DON treated explants. Both DON and its biotransformation products were able to fit into the pockets of the A-site of the ribosome peptidyl transferase center. DON forms three hydrogen bonds with the A site and activates MAPKinases (mitogen-activated protein kinases). By contrast deepoxy-DON and 3-epi-DON only form two hydrogen bonds and do not activate MAPKinases. Our data demonstrate that bacterial de-epoxidation or epimerization of DON altered their interaction with the ribosome, leading to an absence of MAPKinase activation and a reduced toxicity.

  6. Microbial biotransformation of DON: molecular basis for reduced toxicity.

    PubMed

    Pierron, Alix; Mimoun, Sabria; Murate, Leticia S; Loiseau, Nicolas; Lippi, Yannick; Bracarense, Ana-Paula F L; Schatzmayr, Gerd; He, Jian Wei; Zhou, Ting; Moll, Wulf-Dieter; Oswald, Isabelle P

    2016-07-06

    Bacteria are able to de-epoxidize or epimerize deoxynivalenol (DON), a mycotoxin, to deepoxy-deoxynivalenol (deepoxy-DON or DOM-1) or 3-epi-deoxynivalenol (3-epi-DON), respectively. Using different approaches, the intestinal toxicity of 3 molecules was compared and the molecular basis for the reduced toxicity investigated. In human intestinal epithelial cells, deepoxy-DON and 3-epi-DON were not cytotoxic, did not change the oxygen consumption or impair the barrier function. In intestinal explants, exposure for 4 hours to 10 μM DON induced intestinal lesions not seen in explants treated with deepoxy-DON and 3-epi-DON. A pan-genomic transcriptomic analysis was performed on intestinal explants. 747 probes, representing 323 genes, were differentially expressed, between DON-treated and control explants. By contrast, no differentially expressed genes were observed between control, deepoxy-DON and 3-epi-DON treated explants. Both DON and its biotransformation products were able to fit into the pockets of the A-site of the ribosome peptidyl transferase center. DON forms three hydrogen bonds with the A site and activates MAPKinases (mitogen-activated protein kinases). By contrast deepoxy-DON and 3-epi-DON only form two hydrogen bonds and do not activate MAPKinases. Our data demonstrate that bacterial de-epoxidation or epimerization of DON altered their interaction with the ribosome, leading to an absence of MAPKinase activation and a reduced toxicity.

  7. "Don't Lecture Me"

    NASA Astrophysics Data System (ADS)

    2011-11-01

    Often I will listen to public radio on long drives when I am alone. Recently I happened to catch a program called "Don't Lecture Me" and it really caught my attention for several reasons. First, the speakers were all notable leaders in Physics Education Research such as Joe Redish, David Hestenes, and Eric Mazur. (See this month's WebSights column.) These folks are among many who have devoted their energies to understanding how students learn physics and how teachers can design classroom instruction and interactions to best meet the needs of learners. Second, on this particular trip, I had just observed a teacher whose class was very teacher-centered as the teacher lectured most of the class period. As we discussed this later, she expressed concern that she had to cover the material and didn't feel that she could do it without lecturing.

  8. ``Don't Lecture Me''

    NASA Astrophysics Data System (ADS)

    Blanton, Patricia

    2011-11-01

    Often I will listen to public radio on long drives when I am alone. Recently I happened to catch a program called ``Don't Lecture Me'' and it really caught my attention for several reasons. First, the speakers were all notable leaders in Physics Education Research such as Joe Redish, David Hestenes, and Eric Mazur. (See this month's WebSights column.) These folks are among many who have devoted their energies to understanding how students learn physics and how teachers can design classroom instruction and interactions to best meet the needs of learners. Second, on this particular trip, I had just observed a teacher whose class was very teacher-centered as the teacher lectured most of the class period. As we discussed this later, she expressed concern that she had to cover the material and didn't feel that she could do it without lecturing.

  9. Don't Double Up on Acetaminophen

    MedlinePlus

    ... Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products For Consumers Home For Consumers Consumer Updates Don't Double ... products. January 24, 2013 back to top Related Consumer Updates Have a Baby or Young Child With ...

  10. Dry Mouth? Don't Delay Treatment

    MedlinePlus

    ... Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products For Consumers Home For Consumers Consumer Updates Dry Mouth? Don' ... or neck cancer. back to top Advice for Consumers If you have persistent dry mouth: Talk to ...

  11. [Spanish neuroscience in times of Don Quixote].

    PubMed

    Martín-Araguz, Antonio; Mikola, Yvett; Almendral-Doncel, Raquel; Campos-Bueno, Javier

    2016-02-16

    Introduccion. Miguel de Cervantes Saavedra publico su inmortal obra Don Quijote de la Mancha en plena epoca de crisis y decadencia en la España de la transicion entre los siglos XVI y XVII. Objetivo. En 2016 se conmemora el cuarto centenario del fallecimiento de nuestro insigne literato, por cuyo motivo analizamos en este articulo el estado de la neurociencia hispana, tanto en el texto quijotesco como en la obra de los autores coetaneos mas relevantes. Desarrollo. A pesar de las peyorativas circunstancias historicas, en la epoca de la transicion del Renacimiento al Barroco se produjo en la Corona de Castilla un florecimiento de la literatura (Siglo de Oro español) y de otras artes hispanas (pintura, escultura, arquitectura y musica), asi como una prodigiosa creatividad en el campo de la neurociencia, incluida en la filosofia natural. El medico Gomez Pereira, en su libro Antoniana Margarita, se adelanto en decadas a las bases del mecanicismo cerebral y del concepto de reflejo condicionado. El boticario Miguel Sabuco, en su texto Nueva filosofia, anticipo en siglos el concepto de neurotransmision. El medico Juan Huarte de San Juan fue el fundador de la neuropsicologia y la psicologia experimental; su texto Examen de ingenios ha sido uno de los textos cientificos mas influyentes y traducidos de todos los tiempos; sus conceptos quedan patentemente reflejados en el texto cervantino. Conclusion. Este analisis de la obra cervantina dentro del entorno cultural de la obra pretende ser un homenaje a la inmortal figura de nuestro 'Principe de los ingenios' en el cuarto centenario de su fallecimiento.

  12. An ergonomic evaluation of infant life jackets: Donning time & donning accuracy.

    PubMed

    MacDonald, C V; Brooks, C J; Kozey, J W; Habib, A

    2011-01-01

    Canada is considering the development of a new standard for infant/child life jackets. Eight currently available (approved and non-approved) infant/child life jackets were procured for evaluation. Fifty-six participants were chosen as a sample of convenience from the general public for testing. The life jackets were divided into two groups of four, which were donned on a soft infant manikin procured from the Red Cross. In 224 attempts at donning, only 43 (19%) attempts resulted in the life jacket being donned correctly in less than 1 min. Only one life jacket came close to a good design and passed the life jacket standard for donning time and accuracy. Failure rates were observed across all the participants irrespective of age, gender, experience with children and experience with recreational marine equipment. Accuracy and speed of donning the life jacket were hampered as the number of donning sub-tasks increased. It was concluded that it is possible to design a life jacket that can be donned correctly in under 1 min. The life jacket must be of simple, intuitive design and fall naturally into the anatomical shape of the child. A minimum number of ties, zips and clips should be used in the design, and if such connectors are used they should be color coded or of different shapes and sizes to avoid confusion. Copyright © 2010 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  13. The rise of repeal: policy entrepreneurship and Don't Ask, Don't Tell.

    PubMed

    Neff, Christopher L; Edgell, Luke R

    2013-01-01

    We report on policy entrepreneurship by Servicemembers Legal Defense Network (SLDN) and how its legislative strategies used mini-windows of opportunity to shift Capitol Hill perspectives of Don't Ask, Don't Tell (DADT) from political plutonium to an emerging issue requiring a second look. Four phases in the legislative history of DADT are identified: radioactive, contested, emerging, and viable. In all, this article argues that SLDN's entrepreneurship focused on contesting congressional sensibilities to wait or defer on repeal, maintained that every discharge was damaging and transitioned toward a post-repeal mind set. Finally, we illustrate the importance of these transitions by comparing SLDN's 2004 estimated vote count for the introduction of the Military Readiness Enhancement Act with the final 2010 voting results on the Don't Ask, Don't Tell Repeal Act.

  14. Don’t Ask, Don’t Tell: A Time to Go, But How

    DTIC Science & Technology

    2010-02-01

    Mullen expressed the view "that Congress, and not the military, is responsible for the ’Don’t ask, don’t tell’ law banning openly lesbian , gay , and...and discipline to try to integrate gays and lesbians in the current military structure. Skin color is a benign, non-behavioral characteristic. Sexual...Implications for Gender Dissonance for Wayfinding in Gay and Lesbian Neighborhoods,” Florida State University, 2006 45 Benjamin, Stephen, “Don’t Ask

  15. Don Quixote at 400: Still Conquering Hearts

    ERIC Educational Resources Information Center

    Stavans, Ilan

    2005-01-01

    The Knight of the Sorrowful Countenance is turning 400. By some accounts, the first part of Don Quixote, Miguel de Cervantes's masterpiece, was available in Valladolid by Christmas Eve 1604, although Madrid did not get copies until January 1605. Thus came to life the "ingenious gentleman" who, ill equipped with antiquated armor "stained with rust…

  16. The Don Henry Story. Teaching with Documents.

    ERIC Educational Resources Information Center

    National Archives and Records Administration, Washington, DC.

    Don Henry was a student at the University of Kansas (Lawrence, Kansas) who experienced a profound political change during his years on campus. Henry became a leader in radical campus organizations, volunteered to fight in the Spanish Civil War with the Lincoln Brigade, and died on the battlefield in Aragon (Spain) in September 1937. An article in…

  17. The Don Henry Story. Teaching with Documents.

    ERIC Educational Resources Information Center

    National Archives and Records Administration, Washington, DC.

    Don Henry was a student at the University of Kansas (Lawrence, Kansas) who experienced a profound political change during his years on campus. Henry became a leader in radical campus organizations, volunteered to fight in the Spanish Civil War with the Lincoln Brigade, and died on the battlefield in Aragon (Spain) in September 1937. An article in…

  18. Dewey or Don't We?

    ERIC Educational Resources Information Center

    Pendergrass, Devona J.

    2013-01-01

    "Dewey or don't we?" is the question that hundreds, if not thousands, of school librarians across the country are currently asking themselves. Do they throw out what is old but trusted for new organizational systems, or do they continue using the Dewey Decimal Classification (DDC) system and make changes and adjustments to the…

  19. Dewey or Don't We?

    ERIC Educational Resources Information Center

    Pendergrass, Devona J.

    2013-01-01

    "Dewey or don't we?" is the question that hundreds, if not thousands, of school librarians across the country are currently asking themselves. Do they throw out what is old but trusted for new organizational systems, or do they continue using the Dewey Decimal Classification (DDC) system and make changes and adjustments to the…

  20. Don Quixote at 400: Still Conquering Hearts

    ERIC Educational Resources Information Center

    Stavans, Ilan

    2005-01-01

    The Knight of the Sorrowful Countenance is turning 400. By some accounts, the first part of Don Quixote, Miguel de Cervantes's masterpiece, was available in Valladolid by Christmas Eve 1604, although Madrid did not get copies until January 1605. Thus came to life the "ingenious gentleman" who, ill equipped with antiquated armor "stained with rust…

  1. A Conversation with Don Knuth: Part I.

    ERIC Educational Resources Information Center

    Albers, Donald J.; Steen, Lynn Arthur

    1982-01-01

    This interview reviews Don Knuth's life and contributions and his views on a variety of mathematical and computer-related topics. He is viewed as the pre-eminent scholar of computer science in the world, and is probably best known for a series of books titled, "The Art of Computer Programing." (MP)

  2. Don Carl Smellie: Organizer, Motivator, Exemplar, Leader.

    ERIC Educational Resources Information Center

    Gibbons, Andrew S.

    2000-01-01

    Describes the career of Don Carl Smellie who has exerted leadership in the promotion of new technologies for instruction in education, industry, and government. Discusses his founding of the Department of Instructional Technology at Utah Sate University (USU) and its efforts in distance education, technological innovation, international service,…

  3. Quick don-doff electrode pastes

    NASA Technical Reports Server (NTRS)

    Mosier, B.

    1969-01-01

    Evaluation of electrode pastes for use in electrocardiographs and electroencephalographs found that the one having the desired don-doff properties had to be water soluble or a water dispersible base. Poly /methyl vinyl ether/maleic anhydride/ or starch gels of the gum drop variety are two such bases.

  4. Enzyme-Linked Immunosorbent-Assay for Deoxynivalenol (DON)

    PubMed Central

    Ji, Fang; Li, Hua; Xu, Jianhong; Shi, Jianrong

    2011-01-01

    Deoxynivalenol (DON), one of the trichothecene mycotoxins, is a worldwide contaminant of wheat and barley, especially when infected by Fusarium graminearum, the causative agent of an epidemic wheat disease called Fusarium Head Blight. Because of the high risk of DON ingestion and the possibility of frequent exposure, it is important to develop a rapid and highly sensitive method for easy identification and quantification of DON in grain samples. In this study, we have developed an indirect competitive enzyme-linked immunosorbent assay (ELISA) to detect DON in wheat. We conjugated 3-O-Hemisuccinyl-DON (3HS-DON) to Bovine serum albumin (BSA) and Ovalbumin (OVA), and obtained DON-specific mice antisera. The indirect competitive ELISA revealed that the optimal concentration of mice serum and the coated antigen was 1/1600 and 1/1500, respectively. The antiserum cross-reacted with the trichothecenes 3-acetyl-DON and T-2 toxin, reaching about 55.2% and 6.3%, respectively, as compared with DON. Results showed that the assay could be performed satisfactorily using an extraction buffer containing less than 15% methanol. Recovery from DON was 82–93% in grains. The linear detection range of DON in grains was between 0.01 and 100 μg/mL. PMID:22069751

  5. Urinary deoxynivalenol (DON) and zearalenone (ZEA) as biomarkers of DON and ZEA exposure of pigs.

    PubMed

    Thanner, S; Czeglédi, L; Schwartz-Zimmermann, H E; Berthiller, F; Gutzwiller, A

    2016-05-01

    Four diets contaminated with 1.1 to 5.0 mg/kg deoxynivalenol (DON) and 0.4 to 2.4 mg/kg zearalenone (ZEA) were fed to four groups of six growing Large White pigs. Urine samples were collected after 3 to 4 days and again after 6 to 7 days on the diets. On each sampling day, half of the animals were sampled in the morning, after an 8-h fast, and the other half were sampled in the afternoon, after 7 h of ad libitum access to feed. The urinary concentrations of DON, DON-glucuronide, DON-3-sulphate, de-epoxy-DON, as well as of ZEA, ZEA-14-glucuronide, α-zearalenol and α-zearalenol-14-glucuronide, analysed using LC-MS/MS, were used to calculate urinary DON and ZEA equivalent concentrations (DONe and ZEAe). The urinary concentration of DONe (P < 0.001), but not of ZEAe (P = 0.31), was lower in the fasted than that in the fed animals. The urinary DONe/creatinine and ZEAe/creatinine ratios were highly correlated with DON and ZEA intake per kg body weight the day preceding sampling (r = 0.76 and 0.77; P < 0.001). The correlations between DON intake during the 7 h preceding urine sampling in the afternoon and urinary DONe/creatinine ratio (r = 0.88) as well as between mean ZEA intake during 3 days preceding urine sampling and urinary ZEAe/creatinine ratio (r = 0.84) were even higher, reflecting the plasma elimination half-time of several hours for DON and of more than 3 days for ZEA. ZEAe analysed in enzymatically hydrolysed urine using an ELISA kit was highly correlated with the LC-MS/MS data (r = 0.94). The urinary DONe and ZEAe to creatinine ratios, analysed in pooled urine samples of several pigs fed the same diet, can be used to estimate their exposure to DON and ZEA.

  6. Isotopic analysis of bulk, LMW, and HMW DON d15N indicates recycled nitrogen release from marine DON

    NASA Astrophysics Data System (ADS)

    Knapp, A. N.; Sigman, D. M.; Lipschultz, F.; Kustka, A.; Capone, D. G.

    2010-12-01

    Nitrogen (N) concentration and stable isotope ratio (d15N) measurements were made on bulk and size fractionated surface ocean dissolved organic nitrogen (DON) samples collected in the oligotrophic North Atlantic and Pacific Oceans. The bulk DON concentration in the upper 100 m is similar between the North Atlantic and North Pacific, between 4.5 and 5.0 uM, but the average d15N of bulk DON is significantly different, 3.9 per mil vs. air in the North Atlantic and 4.7 per mil in the North Pacific. The d15N of both bulk and HMW DON from the western tropical North Atlantic are similar to previous measurements, ~4.0 to 4.5 per mil. We report the first measurements of LMW DON d15N, which is consistently lower than HMW DON d15N. Neither the concentration nor d15N of bulk or size-fractionated DON varied with in situ N2 fixation rate, although significant variation in bulk and LMW DON d15N was observed between January and July of the same year in the western tropical North Atlantic. We propose a conceptual model to explain 1) the elevated d15N of bulk DON relative to other surface ocean N pools and fluxes, 2) the elevation of HMW DON d15N relative to LMW DON d15N, and 3) the inter-basin difference in the d15N of bulk DON. In this model, DON is produced from suspended particulate organic nitrogen (PON) without isotope fractionation because the conversion from PON to DON largely does not involve N-bearing bonds. In contrast, deamination and amide hydrolysis, with N isotope effects of 3 to 10 per mil, are major mechanisms by which DON is converted to ammonia and/or to other simple N compounds (e.g., amino acids). Thus these N-specific DON loss reactions result in an elevated d15N of residual DON relative to the parent DON and therefore also to the PON source. Moreover, the ammonium and simple organic N compounds released by microbial DON degradation are efficiently reassimilated back into the PON pool, as an integral part of the regenerated N cycle that further lowers the d15N

  7. Stellar polarimetry with ESPaDOnS

    NASA Astrophysics Data System (ADS)

    Petit, P.; Donati, J.-F.; Espadons Project Team

    ESPaDOnS is a new-generation cross-dispersed échelle spectropolarimeter, the commissioning phase of which is scheduled at the Canada-France-Hawaii Telescope (CFHT) for autumn 2003. This instrument will provide full coverage of the optical domain (370nm to 1000nm) in all polarization states (circular and linear) at a resolving power of about 70 000, with a peak efficiency of 20% (telescope and detector included). It includes a bench-mounted spectrograph, fiber-fed from a Cassegrain-mounted module including all polarimetric and calibration facilities.ESPaDOnS should be the most powerful tool dedicated to stellar spectropolarimetry, therefore opening unprecedented perspectives for major issues of stellar physics, from studies of stellar interiors to investigations of stellar atmospheres, stellar surfaces, stellar magnetic fields, and to observations of circumstellar environments and extra-solar planets.

  8. Sleep and sleep disorders in Don Quixote.

    PubMed

    Iranzo, Alex; Santamaria, Joan; de Riquer, Martín

    2004-01-01

    In Don Quijote de la Mancha, Miguel de Cervantes presents Don Quixote as an amazing character of the 17th century who suffers from delusions and illusions, believing himself to be a medieval knight errant. Besides this neuropsychiatric condition, Cervantes included masterful descriptions of several sleep disorders such as insomnia, sleep deprivation, disruptive loud snoring and rapid eye movement sleep behaviour disorder. In addition, he described the occurrence of physiological, vivid dreams and habitual, post-prandial sleepiness--the siesta. Cervantes' concept of sleep as a passive state where all cerebral activities are almost absent is in conflict with his description of abnormal behaviours during sleep and vivid, fantastic dreams. His concept of sleep was shared by his contemporary, Shakespeare, and could have been influenced by the reading of the classical Spanish book of psychiatry Examen de Ingenios (1575).

  9. Polarized Light Experiment, Presa Don Martin, Mexico

    NASA Technical Reports Server (NTRS)

    1989-01-01

    This is a single scene from a pair (frames 021 and 024) to study the effects of polarized light in Earth Observations. One scene was exposed with vertically polarized light, the other, horizontally. The subject in this study, is a lake behind Presa (dam) Don Martin (27.5N, 100.5W) on thge edge of the Rio Grande Plain near it's boundry with the Sierra Madre Oriental in Coahuila, Mexico.

  10. Polarized Light Experiment, Presa Don Martin, Mexico

    NASA Image and Video Library

    1989-05-08

    This is a single scene from a pair (frames 021 & 024) to study the effects of polarized light in Earth Observations. One scene was exposed with vertically polarized light, the other, horizontally. The subject in this study, is a lake behind Presa (dam) Don Martin (27.5N, 100.5W) on thge edge of the Rio Grande Plain near it's boundry with the Sierra Madre Oriental in Coahuila, Mexico.

  11. Don Juan and the vision of Vision.

    PubMed

    Smith, C U

    1981-01-01

    Castaneda's well-known sequence of Don Juan books is used as a paradigmatic example of the relativist position. Central to Don Juan's teaching is the problem of perception: the main task, he constantly reiterates, is simply to 'see', to recognise that the commonsense world we customarily perceive is nothing more than a cultural construct. To combat this thoroughgoing relativism a case study is taken from the early history of visual science. In classical antiquity several fundamentally different 'views' (to use Don Juan's term) of how we see contended for approval. It was only at the beginning of the seventeenth century that the 'modern' interpretation was selected. This interpretation was selected, ultimately, because it 'worked'. Reference is made to both Wittgenstein and Marx to support this appeal to praxis. It is argued that through an intricate, complex, and ill-understood process of popularisation our self-image is ultimately grounded in the theories of natural science; and these, in turn, are ultimately grounded in our action in the world of things.

  12. Impact of multiple consecutive donnings on filtering facepiece respirator fit.

    PubMed

    Bergman, Michael S; Viscusi, Dennis J; Zhuang, Ziqing; Palmiero, Andrew J; Powell, Jeffrey B; Shaffer, Ronald E

    2012-05-01

    A concern with reuse of National Institute for Occupational Safety and Health-certified N95 filtering facepiece respirators (FFRs) is that multiple donnings could stress FFR components, impairing fit. This study investigated the impact of multiple donnings on the facepiece fit of 6 N95 FFR models using a group of 10 experienced test subjects per model. The TSI PORTACOUNT Plus and N95 Companion accessory were used for all tests. After qualifying by passing a standard Occupational Safety and Health Administration fit test, subjects performed up to 20 consecutive tests on an individual FFR sample using a modified protocol. Regression analyses were performed for the percentage of donnings resulting in fit factors (FFs) ≥100 for all 6 FFR models combined. Regression analyses showed statistical significance for donning groups 1-10, 1-15, and 1-20. The mean percentage of donnings with an FF ≥100 was 81%-93% for donning group 1-5, but dropped to 53%-75% for donning group 16-20. Our results show that multiple donnings had a model-dependent impact on fit for the 6 N95 models evaluated. The data suggest that 5 consecutive donnings can be performed before FFs consistently drop below 100. Published by Mosby, Inc.

  13. Don’t Ask, Don’t Tell - Policy Analysis and Interpretation

    DTIC Science & Technology

    1994-06-01

    biological or genetic factors, thereby disputing the idea that homosexuality is an aberrant behavior [Ref. 60]; the presence of " homophobia " in the...don’t like homosexuals. I guess we’re more tolerant than your southern baptists or southern christian religions. That was a good question I think. Q

  14. Reading "Las Meninas": An Ekphrastic Approach to Teaching "Don Quijote"

    ERIC Educational Resources Information Center

    Ortuno, Marian

    2012-01-01

    Reading and teaching "Don Quijote" present multiple challenges to twenty-first century students and instructors who are culturally and historically distanced from the seventeenth century. With "Las Meninas" serving as a visual lexicon for cuing correlative themes and events in "Don Quijote", the instructor, through an ekphrastic, interdisciplinary…

  15. Transgender people in the military: don't ask? Don't tell? Don't enlist!

    PubMed

    Yerke, Adam F; Mitchell, Valory

    2013-01-01

    The repeal of Don't Ask, Don't Tell offered legal equality to sexual minorities in the military. However, this big step forward had no impact on the policy of exclusion and rejection and the fear and secrecy that resulted for transgender people (whether lesbian, gay, bisexual, or heterosexual). In this article, we argue that transgender citizens should have equal opportunity to honorably serve their country, and to be treated with respect and sensitivity as they do so. Many transgender persons may be drawn to military service and its ethos of masculine values. However, they are currently not permitted entry, and, if they are to enter, must remain hidden or face dismissal, leaving them vulnerable to harassment. While they report both positive and negative experiences during their service, research documents discrimination in veterans' healthcare as well as mental health risks resulting from fear and harassment. In contrast to the United States, 11 countries include transgender people in their militaries. Drawing in part from their examples, we end with recommendations for change in the direction of respect and equality of opportunity.

  16. Bioavailability of dissolved organic nitrogen (DON) in wastewaters from animal feedlots and storage lagoons

    USDA-ARS?s Scientific Manuscript database

    Dissolved organic nitrogen (DON) transport from animal agriculture to surface waters can lead to eutrophication and dissolved oxygen depletion. Biodegradable DON (BDON) is a portion of DON that is mineralized by bacteria while bioavailable DON (ABDON) is utilized by bacteria and/or algae. This stu...

  17. The President's pleasant surprise: how LGBT advocates ended Don't Ask, Don't Tell.

    PubMed

    Frank, Nathaniel

    2013-01-01

    This study assesses the role of LGBT advocates in repealing the military's Don't Ask, Don't Tell policy in the U.S. Congress. It draws on the author's direct involvement with that effort as well as personal interviews and media evidence to consider the contributions of the Obama Administration, members of Congress, the media, and individuals and pressure groups in the repeal process. It argues that repeal succeeded not because of the effective implementation of a White House plan but because the pressure of LGBT advocates ultimately shattered several key obstacles including inadequate messaging and dysfunction and inertia among both politicians and interest groups in Washington. The article offers insight into the role of public pressure in forwarding social change.

  18. We don't need another hero.

    PubMed

    Badaracco, J L

    2001-09-01

    Everybody loves the stories of heroes like Martin Luther King, Jr., Mother Teresa, and Gandhi. But the heroic model of moral leadership usually doesn't work in the corporate world. Modesty and restraint are largely responsible for the achievements of the most effective moral leaders in business. The author, a specialist in business ethics, says the quiet leaders he has studied follow four basic rules in meeting ethical challenges and making decisions. The rules constitute an important resource for executives who want to encourage the development of such leaders among their middle managers. The first rule is "Put things off till tomorrow." The passage of time allows turbulent waters to calm and lets leaders' moral instincts emerge. "Pick your battles" means that quiet leaders don't waste political capital on fights they can't win; they save it for occasions when they really want to fight. "Bend the rules, don't break them" sounds easier than it is--bending the rules in order to resolve a complicated situation requires imagination, discipline, restraint, flexibility, and entrepreneurship. The fourth rule, "Find a compromise," reflects the author's finding that quiet leaders try not to see situations as polarized tests of ethical principles. These individuals work hard to craft compromises that are "good enough"--responsible and workable enough--to satisfy themselves, their companies, and their customers. The vast majority of difficult problems are solved through the consistent striving of people working far from the limelight. Their quiet approach to leadership doesn't inspire, thrill, or provide story lines for uplifting TV shows. But the unglamorous efforts of quiet leaders make a tremendous difference every day in the corporate world.

  19. News from the CFHT/ESPaDOnS spectropolarimeter

    NASA Astrophysics Data System (ADS)

    Moutou, C.; Malo, L.; Manset, N.; Selliez-Vandernotte, L.; Desrochers, M.-E.

    2015-12-01

    The ESPaDOnS spectropolarimeter has been in use on the Canada-France-Hawaii Telescope (CFHT) since 2004, for studying stars, galactic objects and planets. ESPaDOnS is used in queued service observing mode since 2008, which allows an optimization of the science outcome. In this article, we summarize the new functionalities and analyses made on ESPaDOnS operations and data for the present and future users. These modifications include: signal-to-noise ratio based observing, radial velocity nightly drifts, the OPERA pipeline under development, the measurement of H2O content in the Maunakea sky, and the use of ESPaDOnS with the neighbour telescope Gemini.

  20. Astronaut John Glenn dons space suit during preflight operations

    NASA Technical Reports Server (NTRS)

    1964-01-01

    Astronaut John Glenn dons space suit during preflight operations at Cape Canaveral, February 20, 1962, the day he flew his Mercury-Atlas 6 spacecraft, Friendship 7, into orbital flight around the Earth.

  1. Pilot Fullerton dons ejection escape suit (EES) on middeck

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Pilot Fullerton dons ejection escape suit (EES) (high altitude pressure garment) life preserver unit (LPU) on forward port side of middeck above potable water tank. Fullerton also adjusts lapbelt fitting and helmet holddown strap.

  2. Don't Let Summer Strain Your Back

    MedlinePlus

    ... Videos & Tools About MedlinePlus Search Search MedlinePlus GO GO About ... of this page: https://medlineplus.gov/news/fullstory_167003.html Don't Let Summer Strain Your Back All that yard work ...

  3. Don Gallo: The Godfather of YA Short Stories.

    ERIC Educational Resources Information Center

    Crowe, Chris

    1997-01-01

    Presents an interview with Don Gallo, editor of seven anthologies of short stories and one collection of plays, and author or editor of seven books about young adult fiction for teachers and scholars. (TB)

  4. When Disaster Strikes, Don't Forget Your Pets

    MedlinePlus

    ... https://medlineplus.gov/news/fullstory_167495.html When Disaster Strikes, Don't Forget Your Pets Prepare kit ... HealthDay News) -- People are urged to prepare for disasters by having an emergency plan, and animal experts ...

  5. Space Station Live: Astronaut Don Pettit on Earth Photography

    NASA Image and Video Library

    In observance of Earth Day, Space Station Live commentator Pat Ryan talks with NASA astronaut Don Pettit, who along with his fellow Expedition 30/31 crew members captured more than a half a million...

  6. Health Tip: Don't Use Sunscreen on Newborns

    MedlinePlus

    ... html Health Tip: Don't Use Sunscreen on Newborns Infants aged 6 months and younger should avoid the ... Health and Human Services. More Health News on Infant and Newborn Care Sun Exposure Recent Health News Related MedlinePlus ...

  7. Popular Heartburn Meds Don't Raise Alzheimer's Risk

    MedlinePlus

    ... 166931.html Popular Heartburn Meds Don't Raise Alzheimer's Risk: Study New research debunks other studies suggesting ... drugs may increase the risk of dementia and Alzheimer's disease in people aged 75 and older. PPIs ...

  8. Speak Up! But don't strain your voice

    MedlinePlus

    ... Past Issues Hearing Disorders Speak Up! But don't strain your voice Past Issues / Fall 2008 Table ... volume," she explains. Although her throat nodules didn't change, Jones reports not having had a sore ...

  9. Lingering Baby Weight? Don't Blame the Pregnancy

    MedlinePlus

    ... news/fullstory_163649.html Lingering Baby Weight? Don't Blame the Pregnancy Researchers find weight gain speeds ... she added. Yakusheva has a theory, which wasn't tested or proven in the study, about why. " ...

  10. Vitamin E, Selenium Don't Cut Colon Cancer Risk

    MedlinePlus

    ... page: https://medlineplus.gov/news/fullstory_162669.html Vitamin E, Selenium Don't Cut Colon Cancer Risk: ... 2016 WEDNESDAY, Dec. 21, 2016 (HealthDay News) -- Taking vitamin E and selenium does not appear to reduce ...

  11. Evaluation of effect of measures taken after a DON outbreak.

    PubMed

    Spanjer, M C; Scholten, J M; Rensen, P M

    2002-03-01

    In April 1999 an amount of 2600 μg/kg DON was found in a sample breakfast cereals in the Netherlands. This event was the start of a lot of activities, which dealt with the prevention, control, health and consumer aspects of DON in food for human consumption. The Food Inspection Services started a monitoring program to measure DON in cereal products, flour and raw cereals. The National Institute of Public Health and the Environment, another part of the Ministry of Health in the Netherlands, was asked to carry out a risk analysis on DON. This was the basis for the Minister of Health to set an action limit for consumer products. She also informed Brussels and asked for a European limit. The Main Board on Agriculture set out to implement measures to be taken at harvesting, milling and bread baking industry. The Scientific Committee on Food of the EC expressed an opinion on DON in December 1999. Worldwide attention leads to discussion of a DON limit by JECFA in February 2001.In the period may 1999 until march 2002 a number of more than 1700 samples were analysed on DON. These originated from the cereal harvest of the years 1998 until 2001. The results showed a sharp decrease of DON content in samples of harvest 1999 when compared to 1998. This lower level was maintained in the 2000 and 2001 harvests. Apparently the measures taken to control the DON level succeeded to maintain values below the action limits. Despite these activities a smaller outbreak of DON appeared in 2001 in pasta products at a lower extent. This indicated that control should be done systematically, not sporadically, and at a European level, which is made possible since EC has set a limit in July 2000. Analytical results of the measurements are presented, together with the chronological order of the associated activities of national, EU and worldwide bodies on human health control. Special attention is paid to DON in bread, related to the level in flour.

  12. The Science of "I Don't Know"

    ERIC Educational Resources Information Center

    Pringle, Tom

    2013-01-01

    When scientists do not know the answer to something, they do two things: admit "I don't know" and say "let's find out". This is the basis of "being scientific"; this is what teachers should also be doing in order to develop scientific literacy in their pupils. The heart of scientific enquiry is this two-part "I don't know, let's find out" attitude…

  13. The Science of "I Don't Know"

    ERIC Educational Resources Information Center

    Pringle, Tom

    2013-01-01

    When scientists do not know the answer to something, they do two things: admit "I don't know" and say "let's find out". This is the basis of "being scientific"; this is what teachers should also be doing in order to develop scientific literacy in their pupils. The heart of scientific enquiry is this two-part "I don't know, let's find out" attitude…

  14. The Metabolic Fate of Deoxynivalenol and Its Acetylated Derivatives in a Wheat Suspension Culture: Identification and Detection of DON-15-O-Glucoside, 15-Acetyl-DON-3-O-Glucoside and 15-Acetyl-DON-3-Sulfate.

    PubMed

    Schmeitzl, Clemens; Warth, Benedikt; Fruhmann, Philipp; Michlmayr, Herbert; Malachová, Alexandra; Berthiller, Franz; Schuhmacher, Rainer; Krska, Rudolf; Adam, Gerhard

    2015-08-12

    Deoxynivalenol (DON) is a protein synthesis inhibitor produced by the Fusarium species, which frequently contaminates grains used for human or animal consumption. We treated a wheat suspension culture with DON or one of its acetylated derivatives, 3-acetyl-DON (3-ADON), 15-acetyl-DON (15-ADON) and 3,15-diacetyl-DON (3,15-diADON), and monitored the metabolization over a course of 96 h. Supernatant and cell extract samples were analyzed using a tailored LC-MS/MS method for the quantification of DON metabolites. We report the formation of tentatively identified DON-15-O-β-D-glucoside (D15G) and of 15-acetyl-DON-3-sulfate (15-ADON3S) as novel deoxynivalenol metabolites in wheat. Furthermore, we found that the recently identified 15-acetyl-DON-3-O-β-D-glucoside (15-ADON3G) is the major metabolite produced after 15-ADON challenge. 3-ADON treatment led to a higher intracellular content of toxic metabolites after six hours compared to all other treatments. 3-ADON was exclusively metabolized into DON before phase II reactions occurred. In contrast, we found that 15-ADON was directly converted into 15-ADON3G and 15-ADON3S in addition to metabolization into deoxynivalenol-3-O-β-D-glucoside (D3G). This study highlights significant differences in the metabolization of DON and its acetylated derivatives.

  15. The plasma clearance of the Fusarium toxin deoxynivalenol (DON) is decreased in endotoxemic pigs.

    PubMed

    Dänicke, Sven; Brosig, Bianca; Kahlert, Stefan; Panther, Patricia; Reinhardt, Nicole; Diesing, Anne-Kathrin; Kluess, Jeannette; Kersten, Susanne; Valenta, Hana; Rothkötter, Hermann-Josef

    2012-12-01

    The plasma elimination kinetics of the Fusarium toxin deoxynivalenol (DON) was investigated in male castrated pigs (40.4±3.7 kg) when infused intravenously either alone (100 μg/kg/h, n=6) or together with lipopolysaccharides (LPS, 7.5 μg/kg/h, n=6). The maximum DON concentration after one hour of infusion was significantly higher by 61% in the DON+LPS Group compared to pigs infused with DON alone. The area under the plasma DON concentration vs. time curve of the DON+LPS Group was approximately twice as high as that of the DON Group after 24h while the initial (0.63 vs. 0.6 h) and terminal half-lifes (2.97 vs. 2.30 h) remained uninfluenced. The apparent volume of distribution and the plasma clearance were significantly lower for the DON+LPS Group compared to the DON Group (2.14 vs. 1.45 L/kg and 11.9 vs. 5.87 mL/kg/min). Glucuronidated DON seemed to persist longer in the DON+LPS Group. In conclusion, clearance of DON was decreased during an LPS induced acute phase reaction in pigs. Whether the higher plasma DON concentrations in endotoxemic pigs are due to a hemodynamically associated longer persistence of the DON glucuronide or because of an altered glucuronidation activity needs to be examined further.

  16. Suicidal Thoughts in the Novel Don Quixote

    PubMed Central

    Pridmore, Saxby; Pridmore, Celeste

    2016-01-01

    Background During the last century suicide has been medicalised. This restrictive view has been challenged, and the wisdom of experts from beyond medicine is being valued. Fictional literature is a source of information regarding the human experience. Objective: To extend our understanding of suicide and suicidal thinking by examining the early-17th Century Spanish novel, “Don Quixote”. Method Various translations were examined for accounts of suicide, suicidal thinking, and associated behaviour. Results There were no accounts of completed suicide. There was one statement indicating the belief that suicide could be triggered by mental disorder. There were five statements indicating that suicidal thinking could arise in situations of distress. Such distress arose from the actual/potential loss of a loved person, suffering by another person, and relentless sleep deprivation. There is one account of a person pretending to attempt suicide and achieving a self-inflicted wound, not with the intention to self-murder, but to impact the disposition of another person. Conclusion The observation that in early-17th Century Spain suicide was acknowledged as means of dealing with distress is consistent with findings from other periods, and the present day. This strengthens the position that suicide can occur in the absence of mental disorder. PMID:27547116

  17. Don't Be Such a Scientist

    NASA Astrophysics Data System (ADS)

    Olson, R.

    2006-12-01

    Academics are bad enough at communication. Science academics are worse. They think too much, they don't care about their image, they assume audiences cherish every word they say, and when the general public fails to embrace them, they blame it on the audience. This is the message of my recent documentary feature film, "Flock of Dodos: the evolution-intelligent design circus." I'm not alone with this message -- others are saying it as well. The world has changed. We live in a new media environment, and changed environments bring about new selective forces. Academic scientists are being challenged as never before, as documented in part in Chris Mooney's bestselling book, "The Republican War on Science." And they must now consider whether they need to adapt, or run the risk of going the way of the dodo. In this talk I will offer up my ten suggestions on how to more effectively reach a broader audience, and then wait for all the scientists to tell me I'm wrong.

  18. Measuring the continuum polarization with ESPaDOnS

    NASA Astrophysics Data System (ADS)

    Pereyra, A.; Rodrigues, C. V.; Martioli, E.

    2015-01-01

    Aims: Our goal is to test the feasibility of obtaining accurate measurements of the continuum polarization from high-resolution spectra using the spectropolarimetric mode of ESPaDOnS. Methods: We used the new pipeline OPERA to reduce recent and archived ESPaDOnS data. Several polarization standard stars and science objects were tested for the linear mode. In addition, the circular mode was tested using several objects from the archive with expected null polarization. Synthetic broad-band polarization was computed from the ESPaDOnS continuum polarization spectra and compared with published values (when available) to quantify the accuracy of the instrument. Results: The continuum linear polarization measured by ESPaDOnS is consistent with broad-band polarimetry measurements available in the literature. The accuracy in the degree of linear polarization is around 0.2-0.3% considering the full sample. The accuracy in polarization position angle using the most polarized objects is better than 5°. Consistent with this, the instrumental polarization computed for the circular continuum polarization is also between 0.2-0.3%. Our results suggest that measurements of the continuum polarization using ESPaDOnS are viable and can be used to study many astrophysical objects. Based on observations obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientique of France, and the University of Hawaii.

  19. 77 FR 21556 - Don Pedro Hydroelectric Project: Turlock Irrigation District; Modesto Irrigation District...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Don Pedro Hydroelectric Project: Turlock Irrigation District; Modesto..., 916-446-0100. c. FERC Contact: Stephen Bowler, Don Pedro Hydroelectric Project, Dispute Resolution...

  20. Parents Don't Always Head to Child's Doctor When Illness Strikes

    MedlinePlus

    ... medlineplus.gov/news/fullstory_164181.html Parents Don't Always Head to Child's Doctor When Illness Strikes ... 20, 2017 (HealthDay News) -- Many American parents don't count on getting a same-day appointment with ...

  1. Distributed Observer Network (DON), Version 3.0, User's Guide

    NASA Technical Reports Server (NTRS)

    Mazzone, Rebecca A.; Conroy, Michael P.

    2015-01-01

    The Distributed Observer Network (DON) is a data presentation tool developed by the National Aeronautics and Space Administration (NASA) to distribute and publish simulation results. Leveraging the display capabilities inherent in modern gaming technology, DON places users in a fully navigable 3-D environment containing graphical models and allows the users to observe how those models evolve and interact over time in a given scenario. Each scenario is driven with data that has been generated by authoritative NASA simulation tools and exported in accordance with a published data interface specification. This decoupling of the data from the source tool enables DON to faithfully display a simulator's results and ensure that every simulation stakeholder will view the exact same information every time.

  2. Cross-reactivity features of deoxynivalenol (DON)-targeted immunoaffinity columns aiming to achieve simultaneous analysis of DON and major conjugates in cereal samples

    PubMed Central

    Gonçalves, Carlos; Stroka, Joerg

    2016-01-01

    ABSTRACT Immunoaffinity columns (IACs) are a well-established tool in the determination of regulated mycotoxins in food and feed commodities. However, they also have the potential to become attractive pre-concentration and clean-up materials for the determination of masked (also called modified) mycotoxins, which have been recognised as important contributors to the toxicological hazard deriving from fungal spoilage of goods. However, the information available in the literature concerning the cross-reactivity of DON-IACs against the major conjugates (DON-3-G, 15-AcDON and 3-AcDON) is incomplete and often contradictory. We have carried out a detailed characterisation of the cross-reactivity of the four main IACs brands against DON and its conjugates as well as an assessment of the competition among the analytes. Only one IAC enabled the simultaneous analysis of all relevant DON forms while two missed 15-AcDON and the fourth one missed DON-3-G and 3-AcDON. In the case of the multivalent IAC, the analytes modified at the C-3 position compete for the antibody binding with preference for 3-AcDON (less spatially hindered) while DON-3-G has the more-hindered access to the active sites. Taking into consideration the levels of DON conjugates existing in real samples, the cross-reactivity of one DON-IAC allows a quantitative analysis of all of these analytes. Important but rather neglected aspects such as the continuous supply of IACs with identical characteristics, and of columns which are strictly blank, are also addressed in this paper. PMID:27243664

  3. Residues of deoxynivalenol (DON) and its metabolite de-epoxy-DON in eggs, plasma and bile of laying hens of different genetic backgrounds.

    PubMed

    Ebrahem, Mohammad; Kersten, Susanne; Valenta, Hana; Breves, Gerhard; Dänicke, Sven

    2014-01-01

    In the present study, the potential for carry-over of deoxynivalenol (DON) into eggs and DON residues in plasma and bile of laying hens of different genetic backgrounds after long-term feeding trial was investigated. A total of 80, 23-week-old laying hens were assigned to a feeding trial with two diets, a control diet and a Fusarium toxin-contaminated diet (FUS) (0.4 and 9.9 mg DON kg(-1), respectively). In the 60th week of hen's life, 10 eggs from each group were collected. In the 70th week of hen's life, all hens were slaughtered and samples of blood and bile were collected. The samples were analysed by liquid chromatography tandem mass spectrometry (LC-MS/MS) for DON and de-epoxy-DON. DON was only detected in samples of hens which fed the FUS diet while none of the samples analysed had detectable levels of de-epoxy-DON. In plasma and bile samples, DON levels ranged from 0.2 to 0.6 ng ml(-1) and from 1.8 to 4.1 ng ml(-1), respectively. DON levels in egg yolk and albumen ranged between 0.0-0.46 ng g(-1) and 0.0-0.35 ng g(-1), respectively, corresponding to carry-over rates of DON into eggs from 0.0 to 0.000016. Moreover, no differences in DON levels or carry-over rates were noticed between the two tested breeds. These results show that very low levels of DON were transferred into eggs and indicate that although eggs could contribute to human exposure to DON, the levels are very low and insignificant.

  4. Cross-reactivity features of deoxynivalenol (DON)-targeted immunoaffinity columns aiming to achieve simultaneous analysis of DON and major conjugates in cereal samples.

    PubMed

    Gonçalves, Carlos; Stroka, Joerg

    2016-06-01

    Immunoaffinity columns (IACs) are a well-established tool in the determination of regulated mycotoxins in food and feed commodities. However, they also have the potential to become attractive pre-concentration and clean-up materials for the determination of masked (also called modified) mycotoxins, which have been recognised as important contributors to the toxicological hazard deriving from fungal spoilage of goods. However, the information available in the literature concerning the cross-reactivity of DON-IACs against the major conjugates (DON-3-G, 15-AcDON and 3-AcDON) is incomplete and often contradictory. We have carried out a detailed characterisation of the cross-reactivity of the four main IACs brands against DON and its conjugates as well as an assessment of the competition among the analytes. Only one IAC enabled the simultaneous analysis of all relevant DON forms while two missed 15-AcDON and the fourth one missed DON-3-G and 3-AcDON. In the case of the multivalent IAC, the analytes modified at the C-3 position compete for the antibody binding with preference for 3-AcDON (less spatially hindered) while DON-3-G has the more-hindered access to the active sites. Taking into consideration the levels of DON conjugates existing in real samples, the cross-reactivity of one DON-IAC allows a quantitative analysis of all of these analytes. Important but rather neglected aspects such as the continuous supply of IACs with identical characteristics, and of columns which are strictly blank, are also addressed in this paper.

  5. Bioprospecting for TRI101 in Fusarium: Searching for a Better Enzyme to Detoxify Deoxynivalenol (DON)

    USDA-ARS?s Scientific Manuscript database

    The mycotoxin deoxynivalenol (DON) is a common contaminant of wheat and barley in the United States. New strategies to mitigate the threat of DON need to be developed and implemented. Previous research has shown the value of an enzyme (TRI101) to modify DON and reduce its toxicity. Recent work by...

  6. DON modification in naturally-contaminated wheat samples using microorganisms isolated from the environment

    USDA-ARS?s Scientific Manuscript database

    The fungus Fusarium graminearum produces the toxic compound deoxynivalenol (DON) that contaminates wheat, barley, and maize. New strategies are needed to mitigate DON in the United States. Microbes were isolated from different soil types, and cultured in a mineral salt media using 100 ppm DON as the...

  7. Diagnosing ALS

    MedlinePlus

    ... that a person diagnosed with ALS seek a second opinion from an ALS "expert" - someone who diagnoses and treats many ALS patients and has training in this medical specialty. The ALS Association maintains a list of recognized experts in the field of ALS. See ALS Association Certified Centers of ...

  8. Don Quixote's countenance before and after losing his teeth.

    PubMed

    del Valle, A; Romero, M

    2009-02-01

    The authors of this paper wish to draw attention to certain not-so-well-known aspects concerning the epithet "Knight of the Woeful Countenance", by which Cervantes' character Don Quixote is universally known. Cervantes used it to highlight the loss of his hero's molars and incisors; thus, the reduced vertical dimension of his face, along with his sagging cheeks and deepened facial furrows, was the reason for his permanently sorrowful countenance. Luis Martínez, a professional illustrator following instructions from the authors of this paper, has recreated the face of Don Quixote as Miguel de Cervantes may well have imagined it for his celebrated character.

  9. Don't drink the water

    NASA Astrophysics Data System (ADS)

    Reed, George W., Jr.

    1999-09-01

    If water exists in permanently shadowed terrain on the moon as suggested by a number of investigators (Watson et al., 1961; Arnold, 1979; Hodges, 1980; Nozette et al., 1996; Duke and Whittaker, 1997) and strongly supported by the Lunar Prospector neutron flux measurements (Feldman et al., 1998), the results of studies on another volatile, namely Hg, are quite relevant. Whereas water has not been positively found, a large number of studies has established the presence of Hg in lunar samples. Its presence and volatile behavior are important when considering water as probably the most important in situ lunar resource. Here we show that the amount of Hg in lunar cold traps may be comparable to the amounts of water.

  10. Lipopolysaccharides (LPS) modulate the metabolism of deoxynivalenol (DON) in the pig.

    PubMed

    Dänicke, Sven; Valenta, Hana; Ganter, Martin; Brosig, Bianca; Kersten, Susanne; Diesing, Anne-Kathrin; Kahlert, Stefan; Panther, Patricia; Kluess, Jeannette; Rothkötter, Hermann-Josef

    2014-08-01

    Pigs might be exposed to lipopolysaccharides (LPS) and deoxynivalenol (DON) at the same time, and both toxins are thought to interactively affect the intestinal barrier, the innate immune system, and the xenobiotics metabolism. Hence, we aimed at examining the single and combined effects of both toxins on nutrient digestibility and DON metabolism. For this purpose, barrows (26 ± 4 kg) were fed restrictedly either a control diet (CON) or a diet contaminated with 3.1 mg DON/kg (DON) for 37 days. At day 37 of the experiment, pigs were infused intravenously for 60 min either with 100 μg DON/kg body weight (BW) (CON-DON), 7.5 μg LPS/kg BW (CON-LPS, DON-LPS) or a combination of both substances (CON-DON + LPS), or physiological saline (CON-CON, DON-CON). Blood samples were collected frequently until 3.25 h before the pigs were sacrificed for bile, liver, and kidney collection. The apparent digestibility of N-free extractives was significantly increased by 1 % when the DON-contaminated diet was fed. The total DON content in blood was significantly higher in endotoxemic pigs (34.8 ng/mL; CON-DON + LPS) when compared to the pigs infused with DON alone (18.8 ng/mL; CON-DON) while bile concentrations were not influenced by LPS. DON residue levels in liver and kidney closely reflected the treatment effects as described for blood. In contrast to DON infusion, the LPS challenge resulted in a significantly lower total DON concentration (13.2 vs. 7.5 ng/mL in groups DON-CON and DON-LPS, respectively) when the pigs were exposed to DON through the diet. The conjugation degree for DON in blood and bile was not influenced by treatments. In conclusion, endotoxemic pigs are characterized by higher DON residue levels in blood, liver, and kidney, probably by a compromised elimination.

  11. Astronaut C. Gordon Fullerton in donning/doffing exercise experiences

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Astronaut C. Gordon Fullerton, STS-3 pilot, experiences free fall while taking part in a suit donning/doffing exercise aboard a KC-135 'zero-gravity' aircraft. Fullerton is wearing an extravehicular mobility unit (EMU) complete with gloves and helmet.

  12. Experiments in rooting bishop pine (Pinus muricata D. Don) cuttings

    Treesearch

    Constance I. Millar

    1987-01-01

    Presented here are results of rooting studies using hedges established from juvenile seedlings of "blue" and "green" foliaged bishop pine (Pinus muricata D. Don) from Mendocino and Sonoma Counties, California. Rootability, averaged over all clones and all setting dates, was 88%. The average time for 50% of the...

  13. SHUTTLE - ASTRONAUT-CANDIDATE (ASCAN) WILLIAMS, DONALD (DON)

    NASA Image and Video Library

    1979-04-03

    S79-30367/69: Exterior views of 747 Shuttle Aircraft. S79-30360/66: ASCAN Don Williams during H Reflex Studies and Hamilton-Standard Tool Belt and Suit Cooling System Tests. 1. AIRCRAFT - 747 2. SHUTTLE - TESTS. S79-30360 thru S79-30369

  14. The Lessons of Don Quixote as Viewed from the Classroom.

    ERIC Educational Resources Information Center

    Perrin, Paulette

    2001-01-01

    Comparing teachers to Don Quixote, the author describes how the profession is caught between modernism and postmodernism. She offers action research and collegiality as ways to break the bounds of the entrenched, hierarchical system of education and its associated cultural values. (SK)

  15. STS-47 Pilot Brown dons LES for JSC bailout training

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-47 Pilot Curtis L. Brown, Jr adjusts his watch during pre-training launch and entry suit (LES) donning in JSC's Mockup and Integration Laboratory (MAIL) Bldg 9A. Brown is preparing for bailout (launch emergency egress) exercises to be conducted in the Crew Compartment Trainer (CCT).

  16. IDEA: An Interdisciplinary Unit Comparing "Don Quixote" to "Hamlet."

    ERIC Educational Resources Information Center

    Harris, Mary J. G.

    2001-01-01

    Describes an idea for teaching language through content-based instruction in which a high school Spanish class studying a shortened abridged version of Cervantes'"Don Quixote" and an English class reading Shakespeare's "Hamlet," did a simple comparative analysis of the two texts. (Author/VWL)

  17. IDEA: An Interdisciplinary Unit Comparing "Don Quixote" to "Hamlet."

    ERIC Educational Resources Information Center

    Harris, Mary J. G.

    2001-01-01

    Describes an idea for teaching language through content-based instruction in which a high school Spanish class studying a shortened abridged version of Cervantes'"Don Quixote" and an English class reading Shakespeare's "Hamlet," did a simple comparative analysis of the two texts. (Author/VWL)

  18. The "Don't Know" Option in Progress Testing

    ERIC Educational Resources Information Center

    Ravesloot, C. J.; Van der Schaaf, M. F.; Muijtjens, A. M. M.; Haaring, C.; Kruitwagen, C. L. J. J.; Beek, F. J. A.; Bakker, J.; Van Schaik, J.P.J.; Ten Cate, Th. J.

    2015-01-01

    Formula scoring (FS) is the use of a don't know option (DKO) with subtraction of points for wrong answers. Its effect on construct validity and reliability of progress test scores, is subject of discussion. Choosing a DKO may not only be affected by knowledge level, but also by risk taking tendency, and may thus introduce construct-irrelevant…

  19. DON occurrence in cereal grains: A North American perspective

    USDA-ARS?s Scientific Manuscript database

    The occurrence of deoxynivalenol (DON) in agricultural commodities has been reported all over the world, with levels varying amongst grain type and years of production. However, a systematic review of the current situation regarding this mycotoxin, its occurrence, and its management in North America...

  20. The "Don't Know" Option in Progress Testing

    ERIC Educational Resources Information Center

    Ravesloot, C. J.; Van der Schaaf, M. F.; Muijtjens, A. M. M.; Haaring, C.; Kruitwagen, C. L. J. J.; Beek, F. J. A.; Bakker, J.; Van Schaik, J.P.J.; Ten Cate, Th. J.

    2015-01-01

    Formula scoring (FS) is the use of a don't know option (DKO) with subtraction of points for wrong answers. Its effect on construct validity and reliability of progress test scores, is subject of discussion. Choosing a DKO may not only be affected by knowledge level, but also by risk taking tendency, and may thus introduce construct-irrelevant…

  1. Responding when Students Don't Get It

    ERIC Educational Resources Information Center

    Fisher, Douglas; Frey, Nancy; Lapp, Diane

    2010-01-01

    When students make mistakes, have misconceptions, or are simply wrong, how their teachers respond either builds new skills and understanding or reinforces errors. An intentional approach to responding when students don't get it includes questions to check for understanding, prompts for cognitive and metacognitive work, cues to divert attention,…

  2. Astronaut C. Gordon Fullerton in suit donning/doffing exercise

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Astronaut C. Gordon Fullerton, STS-3 pilot, takes part in a suit donning/doffing exercise aboard a KC-135 'zero-gravity' aircraft. Mission Specialist William F. Fisher, far left, holds a mirror to assist Fullerton with hose and cable linkups to his suit. Fullerton is wearing an extravehicular mobility unit (EMU) minus gloves and helmet.

  3. Big Books Revisited: An Interview with Don Holdaway. PEN 86.

    ERIC Educational Resources Information Center

    Nicoll-Hatton, Vivienne

    This article presents an interview with Don Holdaway, early childhood educator and originator of "shared book experience." The article first provides a brief summary of themes embodied in Holdaway's first book, "The Foundations of Literacy." It then presents the interview with Holdaway, discussing literacy learning, big books,…

  4. 'Don' a Diploid Falcata Alfalfa for Western US Rangelands

    USDA-ARS?s Scientific Manuscript database

    'Don' (Reg. No. CV-______, PI _______) a diploid falcata alfalfa (Medicago sativa subsp falcata L.) developed by the Forage and Range Research Laboratory in Logan, Utah, in cooperation with the Utah Agricultural Experiment Station, Utah State University. Recent interest in falcata alfalfa has been ...

  5. Pilot Fullerton dons ejection escape suit (EES) on middeck

    NASA Image and Video Library

    1982-03-30

    STS003-23-165 (22-30 March 1982) --- Astronaut Gordon Fullerton, STS-3 pilot, dons ejection escape suit (EES) (high altitude pressure garment) life preserver unit (LPU) on forward port side of middeck above potable water tank. Fullerton also adjusts lapbelt fitting and helmet holddown strap. Photo credit: NASA

  6. The 'Don'ts' of Web Page Design.

    ERIC Educational Resources Information Center

    Balas, Janet L.

    1999-01-01

    Discusses online resources that focus on what not to do in Web page design. "Don'ts" include: making any of the top 10 mistakes identified by Nielsen, qualifying for a "muddie" award for bad Web sites, forgetting to listen to users, and forgetting accessibility. A sidebar lists the Web site addresses for the nine resources…

  7. Fallugia paradoxa (D. Don) Endl. ex Torr.: Apache-plume

    Treesearch

    Susan E. Meyer

    2008-01-01

    The genus Fallugia contains a single species - Apache-plume, F. paradoxa (D. Don) Endl. ex Torr. - found throughout the southwestern United States and northern Mexico. It occurs mostly on coarse soils on benches and especially along washes and canyons in both warm and cool desert shrub communities and up into the pinyon-juniper vegetation type. It is a sprawling, much-...

  8. Astronaut Grissom dons spacesuit for Mercury-Redstone 4 mission

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Donning a spacesuit for the Mercury-Redstone 4 mission, Astronaut Virgil I. (Gus) Grissom chats with spaceflight equipment specialist Joe W. Schmidt in the personal equipment room of Hanger S at Cape Canaveral, Florida. Shortly after this photograph was taken, the launch was postponed two days due to unfavorable weather conditions in the area.

  9. Astronaut Grissom dons spacesuit for Mercury-Redstone 4 mission

    NASA Technical Reports Server (NTRS)

    1961-01-01

    Donning a spacesuit for the Mercury-Redstone 4 mission, Astronaut Virgil I. (Gus) Grissom chats with spaceflight equipment specialist Joe W. Schmidt in the personal equipment room of Hanger S at Cape Canaveral, Florida. Shortly after this photograph was taken, the launch was postponed two days due to unfavorable weather conditions in the area.

  10. MTR BASEMENT. WORKERS (DON ALVORD AND CYRIL VAN ORDEN OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MTR BASEMENT. WORKERS (DON ALVORD AND CYRIL VAN ORDEN OF PHILLIPS PETROLEUM CO.) POSE FOR GAMMA IRRADIATION EXPERIMENT IN MTR CANAL. CANS OF FOOD WILL BE LOWERED TO CANAL BOTTOM, WHERE SPENT MTR FUEL ELEMENTS EMIT GAMMA RADIATION. INL NEGATIVE NO. 11746. Unknown Photographer, 8/20/1954 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  11. Don Quixote --- a possible parent body of a meteor shower

    NASA Astrophysics Data System (ADS)

    Rudawska, R.; Vaubaillon, J.

    2014-07-01

    This talk addresses the topic of meteoroid stream parent body in relation to meteor showers observed on the Earth. We carry out a further search to investigate the possibility of meteor shower observations caused by particles ejected from (3552) Don Quixote. The (3552) Don Quixote asteroid was discovered in 1983 as an Amor asteroid. The Tisserand parameter for the orbit has a value of 2.315 with respect to Jupiter, which indicates a comet-like orbit. The diameter of the object calculated from the absolute magnitude, is in the range of 12.3--24.5 km. It all makes Don Quixote a good candidate for a short-period comet among known near-Earth objects, which the recently observed cometary activity confirms [1]. We have investigated the orbital evolution of the meteoroid stream originated from Don Quixote. If the object was active in the past, it might be a parent body for a meteor shower observed on the Earth. The model for the generation and evolution of the meteoroid stream in the Solar System is taken from [2]. The asteroid's orbital elements and physical properties are taken from the JPL horizons website. The ejections of meteoroids from the asteroid surface took place when the asteroid was passing its perihelion between 5000 B.C. and 2013 A.D. Next, the orbits of ejected meteoroids were integrated to the year 2050. If a meteoroid is sufficiently close to the Earth, its orbital parameters are saved and compared with known showers.

  12. Effects of potential detoxifying agents on growth performance and deoxynivalenol (DON) urinary balance characteristics of nursery pigs fed DON-contaminated wheat.

    PubMed

    Frobose, H L; Stephenson, E W; Tokach, M D; DeRouchey, J M; Woodworth, J C; Dritz, S S; Goodband, R D

    2017-01-01

    Two experiments were conducted to evaluate potential detoxifying agents on growth of nursery pigs fed deoxynivalenol (DON)-contaminated diets. Naturally DON-contaminated wheat (6 mg/kg) was used to achieve desired DON levels. In a 21-d study, 238 pigs (13.4 ± 1.8 kg BW) were used in a completely randomized design with a 2 × 2 + 1 factorial arrangement. Diets were: 1) Positive control (PC; < 0.5 mg/kg DON), 2) PC + 1.0% Product V (Nutriquest LLC, Mason City, IA), 3) Negative control (NC; 4.0 mg/kg DON), 4) NC + 1.0% Product V, and 5) NC + 1.0% sodium metabisulfite (SMB; Samirian Chemicals, Campbell, CA). There were 6 or 7 replicate pens/treatment and 7 pigs/pen. Analyzed DON was decreased by 92% when pelleted with SMB, but otherwise matched formulated levels. Overall, a DON × Product V interaction was observed for ADG ( 0.05) with a tendency for an interaction for ADFI ( 0.10). As anticipated, DON reduced ( 0.001) ADG and ADFI, but the interaction was driven by even poorer growth when Product V was added to NC diets. Pigs fed NC diets had 10% poorer G:F ( 0.001) than PC-fed pigs. Reductions in ADG due to DON were most distinct (50%) during the initial period. Adding SMB to NC diets improved ( 0.01) ADG, ADFI, and G:F, and improved ( 0.02) ADG and G:F compared to the PC diet. A urinary balance study was conducted using diets 3 to 5 from Exp. 1 to evaluate Product V and SMB on DON urinary metabolism. A 10 d adaptation was followed by a 7 d collection using 24 barrows in a randomized complete block design. Pigs fed NC + SMB diet had greater urinary DON output ( 0.05) than pigs fed NC + Product V, with NC pigs intermediate. Daily DON excretion was lowest ( 0.05) in the NC + SMB pigs. However, degradation of DON-sulfonate back to the parent DON molecule was observed as pigs fed NC + SMB excreted more DON than they consumed (164% of daily DON intake), greater ( 0.001) than pigs fed the NC (59%) or NC + Product V (48%). Overall, Product V did not alleviate DON effects

  13. ALS Association

    MedlinePlus

    ... toward a world without ALS! Walk to Defeat ALS® Walk to Defeat ALS® draws people of all ... We need your help. I Will Advocate National ALS Registry The National ALS Registry is a congressionally ...

  14. The Comprehensive Review Working Group and Don't Ask, Don't Tell repeal at the Department of Defense.

    PubMed

    Lee, Jonathan L

    2013-01-01

    In February 2010, Secretary of Defense Robert Gates and Chairman of the Joint Chiefs of Staff Adm. Michael Mullen established the Comprehensive Review Working Group (CRWG) to conduct a comprehensive review of the issues associated with a repeal of Don't Ask, Don't Tell (DADT). Over the next 10 months, the CRWG undertook one of the most extensive studies of a personnel issue in the history of the U.S. military. This article describes the work and the findings of the CRWG (on which the author served) in the context of the activities within the Department of Defense (DoD) following President Obama's call for DADT repeal in his January 2010 State of the Union Address and leading up to the passage of the Don't Ask, Don't Tell Repeal Act in December 2010. It argues that the CRWG served a number of important functions in the DADT repeal process, particularly that it a) provided a rigorous, fact-based assessment of the impacts of repeal from which DoD senior leaders and Congress could base their views; b) developed a road map for a smooth and orderly implementation of repeal; and c) opened a conversation among military service members about what repeal would really mean to them. In doing so, the CRWG contributed to what has been a largely incident-free and successful transition to a post-DADT military.

  15. Subaquatic soils in the Volga, Don and Kuban Rivers deltas.

    NASA Astrophysics Data System (ADS)

    Tkachenko, Anna; Gerasimova, Maria; Lychagin, Mikhail

    2015-04-01

    River deltas occupy a special interface position in the environment and are characterized by contrasting hydrological and landscape-geochemical regimes. Small depth of water and weak currents contribute to suspended matter deposition. Significant spread of aquatic plants provides the enrichment of subaquatic soils in organic matter. All these factors contribute to the formation of different subaquatic soils. Possibility of including them in the classification systems is discussed by many authors (Demas and Rabenhorst, 2001; Stolt et al., 2011); there is also a special subaquatic qualifier for submerged soils in WRB; however, they are still absent in many national classification systems, as well as in the recent Russian one (2008). The purpose of this research is to reveal the properties of the subaquatic soils in the Volga, Don and Kuban Rivers deltaic areas and to propose pedogenetic approaches to categorize AQUAZEMS. Investigations of deltaic areas were performed in 2010-2012 in deltaic lagoons, fresh-water bays, small channels, oxbow lakes, and also in the part of deltaic near-shore zone. Morphological descriptions of distinguishable layers (colour, texture, thickness, boundaries, consistence, plant residues and shell debris) were made in columns obtained by augering as it is done by other researchers (Stolt et al., 2011), and supplemented with analytical data (pH, Eh, TDS, particle-size composition, and Corg). It is suggested to name the horizons in aquazems in the same way as in terrestrial soils in the recent Russian soil classification system, and apply symbols starting with the combination of caps - AQ. Most typical for aquazems is their aquagley AQG horizon that has features similar to terrestrial gleys - homogeneity in color and consistence, permeation by clay, predominance of dove grey colour. The AQG horizon gradually merges into parent material - stratified bottom sediments. The "topsoil" is usually enriched in organic matter and may be different in

  16. Polarized Light Experiment, Presa Don Martin, Coahuila, Mexico

    NASA Technical Reports Server (NTRS)

    1989-01-01

    This is a single scene from a pair (frames 021 and 024) to study the effects of polarized light in Earth Observations. One scene was exposed with vertically polarized light, the other, horizontally. The subject in this study, is a lake behind Presa (dam) Don Martin (27.5N, 100.5W) on the edge of the Rio Grande Plain near it's boundry with the Sierra Madre Orientral in Coahuila, Mexico.

  17. [Sanitary and bacteriological characteristics of water of the lower Don].

    PubMed

    2012-01-01

    The long-term data on the monitoring of bacterial quality of water in the Don River are reported in the article. The evaluation of the epidemiological significance of indicators of microbial pollution of surface water body has been performed Group of Enteric Bacteria and Klebsiella reflect the degree of potential risk of epidemic reservoir most adequately, and a presence of Salmonella and Shigella indicates a direct epidemic danger.

  18. [G. F. d'Acquapendente and Don Carlo Medici's gibbosity].

    PubMed

    Marinozzi, Silvia; Aruta, Alessandro

    2007-01-01

    Don Carlo dei Medici (1595-1666) is the son of Ferdinando I (1549-1609), Granduca of Tuscany, and becomes Cardinal of Catholic Roman Church in 1615. In 1604 Fabrizio d'Acquapendente is called in Florence to treat him, because of an aggravation of his health, and of his congenital neck's gibbosity. The recent paleopathological researches have diagnosed his congenital cervical gibbosity as effect of the Klippel-Feil's syndrome, and characteristic lesions of tubercolosis.

  19. Embezzlement--don't let it happen to you!

    PubMed

    Capko, Judy

    2005-01-01

    Poor financial record keeping and blind trust are invitations for embezzlement. Clever thieves lure you into a false sense of security and complacency. They gain your trust, test the waters, and then go in for the kill. Don't be the victim of an embezzlement scheme that has your practice financing someone else's vacation. Embezzlement is often the result of a casual attitude toward handling finances, general neglect, or perhaps too much trust.

  20. Polarized Light Experiment, Presa Don Martin, Coahuila, Mexico

    NASA Image and Video Library

    1989-05-08

    This is a single scene from a pair (frames 021 & 024) to study the effects of polarized light in Earth Observations. One scene was exposed with vertically polarized light, the other, horizontally. The subject in this study, is a lake behind Presa (dam) Don Martin (27.5N, 100.5W) on the edge of the Rio Grande Plain near it's boundry with the Sierra Madre Orientral in Coahuila, Mexico.

  1. Do's and don'ts of installing a RIS.

    PubMed

    Lehr, J L

    1988-11-01

    This report reviews several important issues relating to the acquisition of a radiology information system (RIS). It emphasizes the importance of defining specific goals for computerizing a department and for understanding that department's manual operations. It then outlines methods to request proposals from prospective vendors and to evaluate their responses. Suggestions for negotiating a favorable arrangement with a vendor follow. Finally, the summary lists five do's and three don'ts for selecting and installing a RIS.

  2. The influence of familiarity on life jacket donning performance: implications for participant selection.

    PubMed

    Macdonald, Conor Vaughan; Brooks, Christopher James; Kozey, John William; Habib, Anthony

    2011-01-01

    Laboratories and test houses keep a "pool" of test subjects that volunteer to be participants in life jacket approval testing, which is believed to be an incorrect procedure. Fifty-six participants donned 8 child/infant life jackets onto 4 infant manikins in random order with time and accuracy of donning recorded. Average donning time for all 8 life jackets decreased significantly after the first donning experience. The findings show that the effect of familiarity occurs immediately after the first test, regardless of life jacket type, thus "contaminating" the subject and making them unsuitable for further tests. These observations are important for life jacket standards where the life jacket must be donned by a naïve participant. Currently, a poorly designed life jacket may receive a pass as a result of the learning effect as shown by participants with previous donning experiences.

  3. [Removal of DON in micro-polluted raw water by coagulation and adsorption using activated carbon].

    PubMed

    Liu, Bing; Yu, Guo-Zhong; Gu, Li; Zhao, Cheng-Mei; Li, Qing-Fei; Zhai, Hui-Min

    2013-04-01

    Dissolved organic nitrogen as a precursor of new type nitrogenous disinfection by-products in drinking water attracted gradually the attention of scholars all over the world. In order to explore the mechanism of DON removal in micro-polluted raw water by coagulation and adsorption, water quality parameters, such as DON, DOC, NH4(+) -N, UV254, pH and dissolved oxygen, were determined in raw water and the molecular weight distribution of the DON and DOC was investigated. The variations in DON, DOC and UV254 in the coagulation and adsorption tests were investigated, and the changes of DON in raw water were characterized using three-dimensional fluorescence spectroscopy. The results showed that DON, DOC and UV254 were 1.28 mg x L(-1), 8.56 mg x L(-1), 0.16 cm(-1), and DOC/DON and SUVA were 6.69 mg x mg(-1), 1.87 m(-1) x (mg x L(-1))(-1) in raw water, respectively. The molecular weight distribution of the DON in raw water showed a bimodal distribution. The small molecular weight (< 6 000) fractions accounted for a high proportion of 68% and the large (> 20 000) fractions accounted for about 22%. The removal of DON, DOC and UV254 was about 20%, 26% and 70%, respectively, in the coagulation test and the dosage of coagulant was 10 mg x L(-1). The removal of DON, DOC and UV254 was about 60%, 35% and 100%, respectively, in the adsorption test and the dosage of activated carbon was 1.0 g. In the combination of coagulation and adsorption, the removal of DON and DOC reached approximately 82% and 64%, respectively. 3DEEM revealed that the variation of DON in the coagulation and adsorption tests depended intimately on tryptophan protein-like substances, aromatic protein-like substances and fulvic acid-like substances.

  4. The myth of the warrior: martial masculinity and the end of Don't Ask, Don't Tell.

    PubMed

    Allsep, L Michael

    2013-01-01

    The image of the male warrior still dominates military culture, to the exclusion of women and homosexuals. Complicating the picture is a technological revolution that promises to widen the current gap between the myth and reality of the modern warrior even further. Nonetheless, despite long arguing that homosexuals were a direct threat to military culture and effectiveness, the Pentagon has largely treated the end of Don't Ask, Don't Tell as a policy matter. The difficulties still experienced by women in the armed services 40 years after they were first incorporated in significant numbers indicates that this response will be insufficient to address the deeper cultural issues. Gender issues implicate deeply held beliefs and values that persist even in the face of years of official admonishment and denial. Unless the military begins to transparently bridge the gap between the myth and reality of the modern warrior, military service without discrimination based on sexual orientation will remain an unachieved goal.

  5. Lesbian, Gay, Bisexual, and Transgender (LGBT) Service Members: Life After Don't Ask, Don't Tell.

    PubMed

    Goldbach, Jeremy T; Castro, Carl Andrew

    2016-06-01

    Lesbian, gay, and bisexual service members can serve openly in the military with the repeal of the Don't Ask, Don't Tell policy. The fate of transgender service members remains uncertain as the policy preventing them from serving in the military remains under review. The health care needs of these populations remain for the most part unknown, with total acceptance and integration in the military yet to be achieved. In this paper, we review the literature on the health care needs of lesbian, gay, bisexual, and transgender (LGBT) service members, relying heavily on what is known about LGBT civilian and veteran populations. Significant research gaps about the health care needs of LGBT service members are identified, along with recommendations for closing those gaps. In addition, recommendations for improving LGBT acceptance and integration within the military are provided.

  6. ALS - resources

    MedlinePlus

    Resources - ALS ... The following organizations are good resources for information on amyotrophic lateral sclerosis : Muscular Dystrophy Association -- www.mda.org/disease/amyotrophic-lateral-sclerosis National Amyotrophic Lateral Sclerosis (ALS) ...

  7. Don Quixote Pond: A Small Scale Model of Weathering and Salt Accumulation

    NASA Technical Reports Server (NTRS)

    Englert, P.; Bishop, J. L.; Patel, S. N.; Gibson, E. K.; Koeberl, C.

    2015-01-01

    The formation of Don Quixote Pond in the North Fork of Wright Valley, Antarctica, is a model for unique terrestrial calcium, chlorine, and sulfate weathering, accumulation, and distribution processes. The formation of Don Quixote Pond by simple shallow and deep groundwater contrasts more complex models for Don Juan Pond in the South Fork of Wright Valley. Our study intends to understand the formation of Don Quixote Pond as unique terrestrial processes and as a model for Ca, C1, and S weathering and distribution on Mars.

  8. On pattern matching with k mismatches and few don't cares.

    PubMed

    Nicolae, Marius; Rajasekaran, Sanguthevar

    2017-02-01

    We consider the problem of pattern matching with k mismatches, where there can be don't care or wild card characters in the pattern. Specifically, given a pattern P of length m and a text T of length n, we want to find all occurrences of P in T that have no more than k mismatches. The pattern can have don't care characters, which match any character. Without don't cares, the best known algorithm for pattern matching with k mismatches has a runtime of [Formula: see text]. With don't cares in the pattern, the best deterministic algorithm has a runtime of O(nk polylog m). Therefore, there is an important gap between the versions with and without don't cares. In this paper we give an algorithm whose runtime increases with the number of don't cares. We define an island to be a maximal length substring of P that does not contain don't cares. Let q be the number of islands in P. We present an algorithm that runs in [Formula: see text] time. If the number of islands q is O(k) this runtime becomes [Formula: see text], which essentially matches the best known runtime for pattern matching with k mismatches without don't cares. If the number of islands q is O(k(2)), this algorithm is asymptotically faster than the previous best algorithm for pattern matching with k mismatches with don't cares in the pattern.

  9. Bioavailability of dissolved organic nitrogen (DON) in wastewaters from animal feedlots and storage lagoons.

    PubMed

    Sun, Jingyi; Khan, Eakalak; Simsek, Senay; Ohm, Jae-Bom; Simsek, Halis

    2017-11-01

    Dissolved organic nitrogen (DON) from animal wastes can contribute to pollution of surface waters. Bioavailable DON (ABDON) is a portion of DON utilized by algae with or without bacteria. This study determined DON and ABDON levels in animal wastewater collected from two different sources: an animal feedlot wastewater storage tank and a sheep wastewater storage lagoon. Inocula for the ABDON bioassays were comprised of individual species and several combinations involving two algae (Chlamydomonas reinhardtii and Chlorella vulgaris) and a mixed liquor suspended solids (MLSS) bacterial culture. The ratio of initial DON to initial total dissolved nitrogen was 18% in the feedlot wastewater samples and 70% in the lagoon wastewater samples. The results showed that between 1.6 and 4.5 mg-NL-1 DON (45-79% of initial DON) in the feedlot samples and between 3.4 and 7.5 mg-NL-1 DON (36%-79% of initial DON) in the lagoon samples were bioavailable with the inocula tested. These results suggest that when considering eutrophication potential of livestock wastewater, organic nitrogen should be included in addition to the obvious culprits, ammonia and nitrate. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Frequent biphasic cellular responses of permanent fish cell cultures to deoxynivalenol (DON)

    SciTech Connect

    Pietsch, Constanze; Bucheli, Thomas D.; Wettstein, Felix E.; Burkhardt-Holm, Patricia

    2011-10-01

    Contamination of animal feed with mycotoxins is a major problem for fish feed mainly due to usage of contaminated ingredients for production and inappropriate storage of feed. The use of cereals for fish food production further increases the risk of a potential contamination. Potential contaminants include the mycotoxin deoxynivalenol (DON) which is synthesized by globally distributed fungi of the genus Fusarium. The toxicity of DON is well recognized in mammals. In this study, we confirm cytotoxic effects of DON in established permanent fish cell lines. We demonstrate that DON is capable of influencing the metabolic activity and cell viability in fish cells as determined by different assays to indicate possible cellular targets of this toxin. Evaluation of cell viability by measurement of membrane integrity, mitochondrial activity and lysosomal function after 24 h of exposure of fish cell lines to DON at a concentration range of 0-3000 ng ml{sup -1} shows a biphasic effect on cells although differences in sensitivity occur. The cell lines derived from rainbow trout are particularly sensitive to DON. The focus of this study lies, furthermore, on the effects of DON at different concentrations on production of reactive oxygen species (ROS) in the different fish cell lines. The results show that DON mainly reduces ROS production in all cell lines that were used. Thus, our comparative investigations reveal that the fish cell lines show distinct species-related endpoint sensitivities that also depend on the type of tissue from which the cells were derived and the severity of exposure. - Highlights: > DON uptake by cells is not extensive. > All fish cell lines are sensitive to DON. > DON is most cytotoxic to rainbow trout cells. > Biphasic cellular responses were frequently observed. > Our results are similar to studies on mammalian cell lines.

  11. Ascaridia galli infection affects pullets differently when feed is contaminated with the Fusarium toxin deoxynivalenol (DON).

    PubMed

    Dänicke, S; Beineke, A; Rautenschlein, Silke; Valenta, Hana; Kersten, Susanne; Gauly, M

    2013-12-06

    The Fusarium mycotoxin deoxynivalenol (DON) is a common contaminant of cereal grains used as animal feed. DON is known for its cytotoxic and anti-proliferative properties and might adversely affect the health of poultry. The prevalence of the intestinal parasitizing roundworm Ascaridia galli is higher in outdoor housing systems and has been associated with maldigestion and malabsorption. It was hypothesized that ingested DON might not only affect the pullet itself but could also act on the nematode parasitizing in the ingesta. To examine these interactions between A. galli infection and DON contamination of feed 4 groups of 9 pullets in each were tested; non-infected groups were fed either an uncontaminated control (CON-) or a Fusarium toxin contaminated and mainly DON-containing diet (FUS-), and the corresponding A. galli inoculated groups were fed accordingly (CON+, FUS+). A. galli infection significantly reduced the jejunal villi height and increased the thickness of the tunica muscularis with the effect being more pronounced when the DON-containing diet was fed (Group FUS+). Only in this group significantly increased weights of jejunal and ileal tissues and of livers were noticed. Moreover, DON was detected in plasma of the pullets at higher frequencies when they were infected suggesting a facilitated absorption of DON. Group FUS+ was characterized by a significantly higher excretion of A. galli eggs and a concomitant lower proportion of pullets with detectable antibodies against a somatic antigen of A. galli while worm burden and worm characteristics were not affected by diet. Other effects of feeding the FUS diet to the infected pullets included an increased mass per length of male worms. In conclusion, infection of pullets with A. galli might increase the susceptibility towards DON as indicated by an increased DON absorption rate and a compromised antibody formation. The effects of DON on fecundity and worm morphology require further examination. Copyright

  12. Effect of deoxynivalenol (DON) mycotoxin on in vivo and in vitro porcine circovirus type 2 infections.

    PubMed

    Savard, Christian; Provost, Chantale; Alvarez, Fernando; Pinilla, Vicente; Music, Nedzad; Jacques, Mario; Gagnon, Carl A; Chorfi, Younes

    2015-04-17

    Deoxynivalenol (DON) is a mycotoxin produced by Fusarium spp and is a common contaminant of grains in North America. Among farm animals, swine are the most susceptible to DON because it markedly reduces feed intake and decreases weight gain. Porcine circovirus type 2 (PCV2) is the main causative agent of several syndromes in weaning piglets collectively known as porcine circovirus-associated disease (PCVAD). The objectives of this study were to investigate the impact of DON on PCV2 replication in NPTr permissive cell line, and to determine eventual potentiating effects of DON on PCV2 infection in pigs. Noninfected and infected cells with PCV2 were treated with increasing concentrations of DON (0, 70, 140, 280, 560, 1200 ng/mL) and cell survival and virus titer were evaluated 72 h postinfection. Thirty commercial piglets were randomly divided into 3 experimental groups of 10 animals based on DON content of served diets (0, 2.5 and 3.5 mg/kg DON). All groups were further divided into subgroups of 6 pigs and were inoculated with PCV2b virus. The remaining pigs (control) were sham-inoculated with PBS. In vitro results showed that low concentrations of DON could potentially increase PCV2 replication depending on virus genotype. In vivo results showed that even though viremia and lung viral load tend to be higher in animal ingesting DON contaminated diet at 2.5 mg/kg, DON had no significant effect on clinical manifestation of PCVAD in PCV2b infected animals. DON has neither in vitro nor in vivo clear potentiating effects in the development of porcine circovirus infection despite slight increases in viral replication. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Adrenalectomy for Cushing's syndrome: do's and don'ts.

    PubMed

    Dn, Paduraru; A, Nica; M, Carsote; A, Valea

    2016-01-01

    Aim. To present specific aspects of adrenalectomy for Cushing's syndrome (CS) by introducing well established aspects ("do's") and less known aspects ("don'ts"). Material and Method. This is a narrative review. Results. The "do's" for laparoscopic adrenalectomy (LA) are the following: it represents the "gold standard" for secretor and non-secretor adrenal tumors and the first line therapy for CS with an improvement of cardio-metabolic co-morbidities; the success rate depending on the adequate patients' selection and the surgeon's skills. The "don'ts" are large (>6-8 centimeters), locally invasive, malignant tumors requiring open adrenalectomy (OA). Robotic adrenalectomy is a new alternative for LA, with similar safety and conversion rate and lower pain drugs use. The "don'ts" are the following: lack of randomized controlled studies including oncologic outcome, different availability at surgical centers. Related to the sub-types of CS, the "do's" are the following: adrenal adenomas which are cured by LA, while adrenocortical carcinoma (ACC) requires adrenalectomy as first line therapy and adjuvant mitotane therapy; synchronous bilateral adrenalectomy (SBA) is useful for Cushing's disease (only cases refractory to pituitary targeted therapy), for ectopic Cushing's syndrome (cases with unknown or inoperable primary site), and for bilateral cortisol producing adenomas. The less established aspects are the following: criteria of skilled surgeon to approach ACC; the timing of surgery in subclinical CS; the need for adrenal vein catheterization (which is not available in many centers) to avoid unnecessary SBA. Conclusion. Adrenalectomy for CS is a dynamic domain; LA overstepped the former OA area. The future will improve the knowledge related to RA while the cutting edge is represented by a specific frame of intervention in SCS, children and pregnant women. Abbreviations: ACC = adrenocortical carcinoma, ACTH = Adrenocorticotropic Hormone, CD = Cushing's disease, CS

  14. An Interview with Don Meyer on Siblings of Individuals with Disabilities

    ERIC Educational Resources Information Center

    Laman, Effie; Shaughnessy, Michael F.

    2007-01-01

    In this article, the authors present an interview with Don Meyer, an advocate for the siblings of children with disabilities. Don Meyer has conducted "SibShops," a peer support and information for school-age siblings of children with disabilities, and written extensively on the difficult situation of children in this underserved demographic. Here,…

  15. Influence of filtration velocity on DON variation in BAF for micropolluted surface water treatment.

    PubMed

    Ma, Teng-Fei; Chen, You-Peng; Kang, Jia; Gao, Xu; Guo, Jin-Song; Fang, Fang; Zhang, Xiao-Tian

    2016-12-01

    Biological aerated filters (BAFs) are widely used for the treatment of micropolluted surface water. However, the biological process produces dissolved organic nitrogen (DON), which, as precursors of nitrogenous disinfection by-products, pose potential threats to drinking water safety. Therefore, to control DON in BAF effluent, it is necessary to study the influence of BAF operation parameters on DON production. In this study, the influence of filtration velocity in a BAF on DON production was investigated. Under different filtration velocity (0.5, 2, and 4 m/h) conditions, profiles of DON concentrations along the media layer were measured. The profile at a filtration velocity of 0.5 m/h showed a decreasing trend, and the ones under filtration velocities of 2 and 4 m/h fluctuated in a small range (from 0.1 to 0.4 mg/L). Moreover, the relatively high filtration velocities of 2 and 4 m/h resulted in a lower level of DON concentration. Additionally, 3D excitation-emission matrix fluorescence spectroscopy was used to characterize DON. It is found that the patterns of DON at a relatively high filtration velocity condition (4 m/h) were obviously different from the ones under low filtration velocity conditions (0.5 and 2 m/h).

  16. Can we restore the fire process? What awaits us if we don't?

    Treesearch

    R. Gordon Schmidt

    1996-01-01

    This paper's title - "Can we restore the fire process? What awaits us if we don't?" - represents an ecologist's view of the world. I submit that this view is unrealistic. The first clause uses the term "restore" which implies reestablishing the fire process of the past. The second phrase uses the absolute term "don't"...

  17. Don't force change--facilitate it.

    PubMed

    Wojciak, P J

    1997-08-01

    Many projects are planned well but seem to fail in the implementation stage. We've all been in that situation to one degree or another, so we know that planning, in and of itself, does not dictate success. What is the link between planning and success that is missed so often? While a project with no plan is doomed to failure, a well-planned project can fail just as easily if you can't execute the plan. The ability to keep your team motivated and the project moving forward is critical, and most project leaders don't recognize some fundamentals that are prerequisites for success.

  18. [Pica, a strange symptom unveiled even in "Don Quixote"].

    PubMed

    Larraín, Camilo

    2005-05-01

    Pica, the compulsive eating of non edible substances, is known by the medical profession for centuries. In the novel by Miguel de Cervantes "Adventures of the famous knight Don Quixote de la Mancha'', there is a history in which "women that by caprice eat soil, plaster coal and other disgusting substances'' are mentioned. This description configures the clinical diagnosis of pica. This fact has not attracted the attention of the critics of Cervantes' novel, up to now. This unequivocal reference of pica suggests that iron deficiency anemia, caused by chronic hemorrhages in adults, was frequent in 1605, when the book was first published.

  19. "Deficits Don't Matter": Abundance, Indebtedness and American Culture.

    PubMed

    Kroes, Rob

    If deficits, nor defaults, don't really matter anymore, what sign of our times is it? What has changed from the days that Franklin Delano Roosevelt risked the fragile economic recovery from the great depression by returning, in 1937, to the standard of his economic orthodoxy, a belief in fiscal rectitude and anaversion to debts and deficits? If that was a sign of a certain American character, what has happened to it? A massive shift in public culture must have occurred, affecting people's views on public probity and political rectitude. The following is an attempt to trace some of the main shifts on the way to our present quandary.

  20. Checking Your Vendors' References: Don't Cut Corners.

    PubMed

    Boden, Timothy W

    2015-01-01

    Physicians and practice managers sometimes demonstrate a little too much trust when making major purchases. The vendor assures you that its product is high-quality, reliable, and easy to implement. Due diligence on your part demands that you ask for appropriate references--satisfied customers who will tell you the truth about their experiences. But you need to go further: Don't simply rely on the vendor's list of satisfied buyers. Do your best to compare "apples to apples." Find practices that are similar to your own in size, setting, and specialty.

  1. Don't let safety happen by accident.

    PubMed

    Blaco, C E

    1992-02-01

    Get ready to update and improve your company's safety program. On pages 24-38, you'll find a comprehensive guide to safe industry practices to enhance your operation and help you stay in compliance with OSHA regulations such as the General Duty Clause and the Right-to-Know law. Achieving a safe, healthy, productive, and profitable business doesn't happen by accident. It takes upper-management commitment to improve equipment, procedures, and employee training. Managers have a personal and a legal responsibility for employees' safety on the job. Don't delay safety improvements!

  2. 77 FR 64973 - Don W. Gilbert Hydro Power, LLC; Notice of Application Accepted for Filing With the Commission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... Energy Regulatory Commission Don W. Gilbert Hydro Power, LLC; Notice of Application Accepted for Filing.... Date filed: May 30, 2012. d. Applicant: Don W. Gilbert Hydro Power, LLC. e. Name of Project: Gilbert...Ann G. Somonich, Don W. Gilbert Hydro Power, LLC, 1805 Grace Power Plant Road, Grace, Idaho...

  3. 78 FR 76103 - Donald V. Bernardo, a/k/a Don Bernarndo, 701 Fredericksburg Road, Mathews, NC 28105; Order...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... Bureau of Industry and Security Donald V. Bernardo, a/k/a Don Bernarndo, 701 Fredericksburg Road, Mathews... District of Florida, Donald V. Bernardo, a/k/a Don Bernardo (``Bernardo''), was convicted of Section 38 of..., Donald V. Bernardo, a/k/a Don Bernardo, with a last known address at: 701 Fredericksburg Road,...

  4. [Don-Juanism. Sexual formation of style as a culture-historical phenomenon and psychiatric problem].

    PubMed

    Holzbach, E

    1977-01-01

    This is a representation of the developing of "Don Juan" from a dramatic figure into a prototype of a particular human behaviour. First was described a general view of the literary dramatic essay on this theme, of the philosophical, psychoanalytic, anthropological, sexual-pathological aspects of the figure of Don Juan and of "Don Juanism". Then a case of Don Juanism was discussed. The special characteristic style of sexual behaviour was not seen isolatedly, but was regarded as an expression of a special structure of social behaviour. Finally an attempt was made to depict the different interpretations of the figure of Don Juan within our cultural reach in a common perspective. The interpretation and evaluation of this phenonmenon essentially refer to the anthropological conception of v. Gebsattel and Giese.

  5. Microbial Detoxification of Deoxynivalenol (DON), Assessed via a Lemna minor L. Bioassay, through Biotransformation to 3-epi-DON and 3-epi-DOM-1

    PubMed Central

    Vanhoutte, Ilse; De Mets, Laura; De Boevre, Marthe; Uka, Valdet; Di Mavungu, José Diana; De Saeger, Sarah; De Gelder, Leen; Audenaert, Kris

    2017-01-01

    Mycotoxins are toxic metabolites produced by fungi. To mitigate mycotoxins in food or feed, biotransformation is an emerging technology in which microorganisms degrade toxins into non-toxic metabolites. To monitor deoxynivalenol (DON) biotransformation, analytical tools such as ELISA and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) are typically used. However, these techniques do not give a decisive answer about the remaining toxicity of possible biotransformation products. Hence, a bioassay using Lemna minor L. was developed. A dose–response analysis revealed significant inhibition in the growth of L. minor exposed to DON concentrations of 0.25 mg/L and higher. Concentrations above 1 mg/L were lethal for the plant. This bioassay is far more sensitive than previously described systems. The bioassay was implemented to screen microbial enrichment cultures, originating from rumen fluid, soil, digestate and activated sludge, on their biotransformation and detoxification capability of DON. The enrichment cultures originating from soil and activated sludge were capable of detoxifying and degrading 5 and 50 mg/L DON. In addition, the metabolites 3-epi-DON and the epimer of de-epoxy-DON (3-epi-DOM-1) were found as biotransformation products of both consortia. Our work provides a new valuable tool to screen microbial cultures for their detoxification capacity. PMID:28208799

  6. The Fusarium toxin deoxynivalenol (DON) modulates the LPS induced acute phase reaction in pigs.

    PubMed

    Dänicke, Sven; Brosig, Bianca; Kersten, Susanne; Kluess, Jeannette; Kahlert, Stefan; Panther, Patricia; Diesing, Anne-Kathrin; Rothkötter, Hermann-Josef

    2013-07-04

    The systemic effects of the Fusarium toxin deoxynivalenol (DON) and of bacterial lipopolysaccharides (LPS) were studied in male castrated pigs (40.4 ± 3.7 kg) infused intravenously with either DON or LPS alone (100 μg DON/kg/h, 7.5 μg/LPS/kg/h), or together (100 μg DON plus 7.5 μg/LPS/kg/h). The Control group received a saline infusion (n=6/treatment, 24h observation period). An additional DON infusion did not exacerbate the clinical signs observed in LPS-infused pigs. For example, rectal temperature climaxed after 4h (40.4 ± 0.2°C) and 5h (40.1 ± 0.3°C), in the LPS and LPS+DON group, respectively. Saline and DON alone did not induce an acute phase reaction as indicated by unaltered plasma levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) while LPS caused a significant rise of both cytokines. TNF-alpha plasma peak concentrations were significantly higher in the LPS compared to the DON+LPS group (94.3 ± 17.2 ng/mL vs. 79.2 ± 15.7 ng/mL) while IL-6 climaxed earlier in the latter group (3h p.i. vs. 2h p.i.). From the tested clinical-chemical plasma characteristics the total bilirubin concentration and the ASAT activity were strongly elevated by the LPS infusion and additionally increased and decreased by DON, respectively. In conclusion, the LPS-induced effects were only marginally modified by DON.

  7. Hexokinase plays a critical role in deoxynivalenol (DON) production and fungal development in Fusarium graminearum.

    PubMed

    Zhang, Leigang; Li, Baicun; Zhang, Yu; Jia, Xiaojing; Zhou, Mingguo

    2016-01-01

    Fusarium graminearum, the causal agent of Fusarium head blight, is a common pathogen on small grain cereals worldwide and produces various trichothecenes [deoxynivalenol (DON) is predominant] during infection. A previous study has revealed that DON production is positively correlated with the occurrence of carbendazim (MBC) resistance. Here, we identified and characterized two putative genes encoding hexokinase in F. graminearum (FgHXK1 and FgHXK2), which is a rate-limiting enzyme in DON biosynthesis. The expression level of hexokinase genes and the production of pyruvate, which is the precursor of DON, were up-regulated in the MBC-resistant strain, indicating that hexokinase genes might be involved in increased DON production. Phylogenetic and comparative analyses indicated that FgHXK1 was the predominant hexokinase gene. Gene disruption showed that ΔFgHXK1 severely affected DON production, indicating that FgHXK1 played a role in the regulation of DON biosynthesis. Morphological characterization showed that ΔFgHXK1 led to inhibited vegetative growth and conidiation. Sensitivity tests to MBC and various stresses indicated that both ΔFgHXK1 and ΔFgHXK2 mutants showed no significant difference from parental strains. Pathogencity assays showed that ΔFgHXK1 mutants lost virulence on wheat head and corn stigma; however, they showed no change in sexual reproduction. The FgHXK1-overexpressing transformants were obtained subsequently. Their pyruvate and DON production was confirmed to be increased, indicating that FgHXK1 positively regulated DON biosynthesis. Although additional defects appeared in overexpression mutants, MBC sensitivity showed no change. All of the results indicated that the transcriptional level of FgHXK1 regulated DON biosynthesis, but showed no direct relationship with MBC resistance.

  8. Biomechanical simulation of high-heeled shoe donning and walking.

    PubMed

    Yu, Jia; Cheung, Jason Tak-Man; Wong, Duo Wai-Chi; Cong, Yan; Zhang, Ming

    2013-08-09

    Footwear serves to protect the foot in various activities, to enhance athletic performance in sports and in many cases to fulfill aesthetic and cultural needs of urban society. Most women like wearing high-heeled shoes (HHS) for the benefit of sensuous attractiveness, while foot problems are often associated. Computational modeling based on finite element (FE) analysis is a useful tool for deep understanding of foot and footwear biomechanics and incorporating footwear with foot in the model is the prerequisite. In this study, a three-dimensional FE model of coupled foot-ankle-shoe complex and preceding gait simulation were established. Interfacial contact simulation was employed to complete the donning process of foot and shoe upper contact. Three major stance phases namely heel strike, midstance and push off were simulated to investigate the biomechanical response of high-heeled shod walking. It was found that the contact pressure at all metatarsophalangeal (MTP) joints intensified and reached their maximum at push off phase during locomotion, meanwhile the first MTP had the largest magnitude. The first and fifth MTP joints had larger movements in transverse plane among all MTP joints, indicating that these two joints bended more significantly by toe box restraint during locomotion. The dorsal contact pressure at the first toe increased by four times from heel strike to push off. The established HHS donning and walking simulation in this study proved the versatility and promising potential of computational approach for realistic biomechanical evaluation and optimization of footwear design in a virtual environment.

  9. Hydrogen peroxide induced by the fungicide prothioconazole triggers deoxynivalenol (DON) production by Fusarium graminearum

    PubMed Central

    2010-01-01

    Background Fusarium head blight is a very important disease of small grain cereals with F. graminearum as one of the most important causal agents. It not only causes reduction in yield and quality but from a human and animal healthcare point of view, it produces mycotoxins such as deoxynivalenol (DON) which can accumulate to toxic levels. Little is known about external triggers influencing DON production. Results In the present work, a combined in vivo/in vitro approach was used to test the effect of sub lethal fungicide treatments on DON production. Using a dilution series of prothioconazole, azoxystrobin and prothioconazole + fluoxastrobin, we demonstrated that sub lethal doses of prothioconazole coincide with an increase in DON production 48 h after fungicide treatment. In an artificial infection trial using wheat plants, the in vitro results of increased DON levels upon sub lethal prothioconazole application were confirmed illustrating the significance of these results from a practical point of view. In addition, further in vitro experiments revealed a timely hyperinduction of H2O2 production as fast as 4 h after amending cultures with prothioconazole. When applying H2O2 directly to germinating conidia, a similar induction of DON-production by F. graminearum was observed. The effect of sub lethal prothioconazole concentrations on DON production completely disappeared when applying catalase together with the fungicide. Conclusions These cumulative results suggest that H2O2 induced by sub lethal doses of the triazole fungicide prothioconazole acts as a trigger of DON biosynthesis. In a broader framework, this work clearly shows that DON production by the plant pathogen F. graminearum is the result of the interaction of fungal genomics and external environmental triggers. PMID:20398299

  10. Mission Analysis for the Don Quijote Phase-A Study

    NASA Technical Reports Server (NTRS)

    Cano, Juan L.; Sanchez, Mariano; Cornara, Stefania; Carnelli, Ian

    2007-01-01

    The Don Quijote Phase-A study is a definition study funded by ESA and devoted to the analysis of the possibilities to deflect a Near Earth Object (NEO) in the range of 300-800 m diameter. DEIMOS Space S.L. and EADS Astrium have teamed up within this study to form one of the three consortia that have analyzed these aspects for ESA. Target asteroids for the mission are 1989 ML, 2002 AT4 and Apophis. This paper presents the mission analysis activities within the consortium providing: low-thrust interplanetary rendezvous Orbiter trajectories to the target asteroids, ballistic interplanetary trajectories for the Impactor, Orbiter arrival description at the asteroids, Orbiter stable orbits characterization at the asteroid, deflection determination by means of a Radio Science Experiment (RSE) as well as the mission timelines and overall mission scenarios.

  11. Don Clayton and Nuclear Gamma-Ray Astronomy

    NASA Technical Reports Server (NTRS)

    Fishman, Jerry

    2005-01-01

    For over four decades, Don Clayton has been a driving force in nuclear gamma-ray astronomy. During the 1960's, he published the first papers that gave us the scientific objectives for many balloon-borne and satellite-borne observations to come. He inspired others to work in this field as both theorists and observers. Later, he was a strong advocate for a major observatory; he helped get the Compton Gamma Ray Observatory off the ground. Over the years, he has advised and mentored many who are now among the leaders in our field. I will attempt to summarize his many contributions to theory and the interpretation of observations in this field.

  12. Preparación de los adultos mayores en los Estados Unidos para hacer frente a los desastres naturales: encuesta a escala nacional*

    PubMed Central

    Al-rousan, Tala M.; Rubenstein, Linda M.; Wallace, Robert B.

    2015-01-01

    Objetivos. Nos propusimos determinar el grado de preparación frente a los desastres naturales de los adultos mayores en los Estados Unidos y evaluar los factores que pueden afectar negativamente la salud y la seguridad durante este tipo de incidentes. Métodos. Obtuvimos una muestra de adultos de 50 años en adelante (n = 1 304) de la encuesta del 2010 del Estudio de la Salud y la Jubilación (HRS por su sigla en inglés). La encuesta recogió datos sobre las características demográficas generales, el estado de discapacidad o las limitaciones funcionales, y también sobre factores y comportamientos relacionados con la preparación frente a los desastres. Calculamos una puntuación global de preparación mediante indicadores individuales a fin de evaluar el grado de preparación general. Resultados. La media de la edad de los participantes (n = 1 304) fue de 70 años (desviación estándar [DE] = 9,3). Solo 34,3% informaron que habían participado en un programa formativo o que habían leído materiales sobre la preparación para los desastres. Casi 15% indicaron que usaban dispositivos médicos eléctricos que podían correr riesgo de no funcionar si se interrumpiera el suministro eléctrico. La puntuación de preparación indicó que la edad más avanzada, la discapacidad física y el menor nivel de escolaridad y de ingresos se asociaban independiente y significativamente a un grado de preparación general inferior. Conclusiones. A pesar de la mayor vulnerabilidad ante los desastres y del número cada vez mayor de adultos mayores en los Estados Unidos, muchos de los problemas sustanciales que encontramos son remediables y requieren atención en los sectores de la sociedad dedicados a la atención clínica, a la salud pública y al manejo de situaciones de emergencia.

  13. Diagnosing a male hysteric: Don Juan-type.

    PubMed

    Lubbe, Trevor

    2003-08-01

    The aim of this paper is to provide a clinical account of a male hysteric, Don Juan-type, taken from the early stages of treatment. The patient presented with a relationship problem but there soon emerged a form of compulsive sexuality or hypersexuality in his love relations that became a central feature of the clinical picture. This hypersexuality expressed itself in a compulsive need to stage, or to stage-manage, interpersonal scenaria of a sexual or sexualised nature. These scenaria, which were repeated in different variations and with different personnel, are seen by the author as a dramatisation of the primal scene with the patient taking up the position of the oedipal father. Explanations for the disappearance of male hysteria are given, including a new theory which claims that an imbalance in psychoanalytic theory itself led to the feminisation of hysteria. This critique allows certain forms of hypersexuality in men to be promoted as a form of hysteria, the most common example being Don Juanism-a form of compulsive sexuality that encompasses normative, conversion and character features. The paper also examines the male hysteric's developmental agenda. What the patient's compulsive sexual tableaux exposed was that he had never faced a separation that was not a triangular experience. This meant that his separations were experienced as two developmental agonies telescoped into one-separation (pre-oedipal) and exclusion (early oedipal). This combination, the author suggests, is so frightening in a particular group of men as to explain the choice of hysteria as opposed to some other choice of neurosis.

  14. The fate of Don Juan: the myth and the man.

    PubMed

    Brockman, D D

    1992-01-01

    The literary character of Don Juan has offered an opportunity to study certain characteristics in an adult man who began a behavior pattern in adolescence that resembled the legendary and mythical Don Juan. Power and dominating control issues were paramount defenses against a narcissistic depression in this man as seen in his relationships with women and in the transference relationship with me. The transference data have been put to use in providing a formulation for an explanation of the phenomena observed. Other clinical data concerning women and some homosexual men are presented in a more abbreviated fashion. This research effort is a retrospective construction of the dynamics that led to this man's neurosis. In my opinion, a self psychological interpretation offers the more felicitous fit than the classic oedipal interpretation. In fact, at first I tried interpretations based on classic oedipal theory--concerning issues of competition with me as father and fear of retaliation and castration--but this strategy resulted in little or no response. More important than symptomatic response, however, the data minimally and weakly supported those interpretations. To be sure, there were and still are competitive and phallic oedipal issues. Moreover, when the patient's mother died, he was drawn into a closer relationship with his father, a relationship accompanied by wishes and fantasies of taking his mother's place. These wishes were quite real, but, as the analysis preceeded, this negative oedipal configuration occupied a much less prominent place in the dynamics. Power and control issues dominated the clinical picture, masking a depression emanating from a deeper narcissistic focus. Interpretation of these narcissistic issues provided my patient with the relief he was seeking, while the main effect of the antidepressant medication was to help him sleep. By giving him something, a deeply seated wish was gratified and was in keeping with an idealized mother

  15. Scientific Communication for Positive Action: Do's and Don'ts

    NASA Astrophysics Data System (ADS)

    Sanquini, A.; Wood, M. M.

    2015-12-01

    Natural hazard presentations often highlight disasters that may ensue from natural processes when mitigation or preparedness actions are not taken. Examples include images of raging fires, collapsed buildings, and flooded urban areas. Research has shown that this makes presentations more interesting and more memorable. Such images are the stock and trade of disaster reporting by the media. Unfortunately, it may also trigger avoidance and denial in the audience, resulting in preparedness reduction; the opposite effect of what may have been intended by the speaker. Recent social research has provided insight into a better approach. The theory of communicating actionable risk posits that people will take action against hazards when they know what to do, think it would work, and know someone who did it. This approach was recently applied in an intervention designed to motivate earthquake-resistant construction in Kathmandu Valley, Nepal. Social theory further suggests that a tendency towards action is strengthened by hearing a consistent message over time, and by providing the audience with an appropriate opportunity to seek out relevant information. This presentation shows how, by taking this transdisciplinary step, scientists can make small changes in their hazard communication, thereby acting as positive influencers of change. A summary of "do's" and "don'ts" is given for reference. 1. Show examples of what to do. 2. Show effectiveness of actions. 3. Give sense of knowing someone who did it. 4. Deliver consistent message, repeatedly. 5. Give opportunity for more information. DON'T: 1. Make the disaster the star. 2. Contradict other communications.

  16. In Drosophila, don juan and don juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF II80 cannonball while translational repression is achieved by distinct elements.

    PubMed

    Hempel, Leonie U; Rathke, Christina; Raja, Sunil Jayaramaiah; Renkawitz-Pohl, Renate

    2006-04-01

    The genes don juan (dj) and don juan like (djl) encode basic proteins expressed in the male germline. Both proteins show a similar expression pattern being localized in the sperm heads during chromatin condensation and along the flagella. Prematurely expressed Don Juan-eGFP and Myc-Don Juan Like localize to the cytoplasm of spermatocytes and in mitochondrial derivatives from the nebenkern stage onward suggesting that both proteins associate with the mitochondria along the flagella in elongated spermatids. Premature expression of Myc-Don Juan Like does not impair spermatogenesis where-as Don Juan-eGFP when prematurely expressed causes male sterility as spermatids fail to individualize. In spite of the sequence identity of 72% on the nucleotide level and 42% on the protein level, the presumptive promoter regions and the untranslated regions of the mRNA are diverged. Our in vivo analysis revealed that don juan and don juan like are transcriptionally and translationally controlled by distinct short cis regulatory regions. Transcription of don juan and don juan like depends on the male germ line specific TAF(II)80, Cannonball (Can). Translational repression elements for both mRNAs are localized in the 5' UTR and are capable to form distinct secondary structures in close proximity to the translational initiation codon.

  17. Re: Don't dive cold when you don't have to.

    PubMed

    Pollock, Neal W

    2015-09-01

    The letter by Clarke et al unfortunately misrepresents the work at the US Navy Experimental Diving Unit (NEDU) to which it refers, and delivers a confused picture of the physiological impact of thermal status on decompression stress. A series of earlier reports outline the importance of thermal status. Being warm during a dive results in higher post-dive Doppler bubble scores. Hot water suits are associated with a higher rate of decompression sickness (DCS) than passively insulated drysuits. Post-dive cooling can prolong the risk window for developing symptoms of skin bends.The NEDU chamber study provided an elegant design to further assess the impact of thermal stress. Dives to 37 msw (120 fsw) were divided into descent/bottom and ascent/stop phases, prolonging the latter so that bottom times could be increased if results allowed without compromising the experimental structure. The water temperature was held at either 36 °C (97 °F; 'warm') or 27 °C (80 °F; 'cold'). The 'warm/cold' exposure, with a bottom time of 30 minutes, yielded a DCS rate of 22% (7/32 subject-exposures). The 'cold/warm' bottom time was increased to 70 minutes and still yielded a DCS rate of only 1.3% (2/158). Even if the effects are exaggerated by the prolonged ascent/stop phase, the dramatic results demand serious attention. Contrary to the claim made by Clarke et al in their letter, the high temperature employed in the NEDU study could almost certainly be maintained at the skin by a number of active heating garments available to the diving public. Hot water suits are not required for the effect; and the 'cold' study temperature (better described as 'cool') is clearly well within the range experienced by divers. The statement by Clarke et al that "the Navy uses their extensive mathematical expertise to select the one dive profile that, in their estimation, is the most likely to identify a difference in decompression risk..." is frankly baffling. Use of a single dive depth in no way

  18. Many Breast Cancer Survivors Don't Get Life-Extending Therapy

    MedlinePlus

    ... https://medlineplus.gov/news/fullstory_163387.html Many Breast Cancer Survivors Don't Get Life-Extending Therapy Study ... reduce the likelihood that women diagnosed with certain breast cancers will experience a recurrence of their disease. However, ...

  19. Most Cow's Milk Baby Formulas Don't Up Risk of Type 1 Diabetes

    MedlinePlus

    ... medlineplus.gov/news/fullstory_163146.html Most Cow's Milk Baby Formulas Don't Up Risk of Type ... THURSDAY, Jan. 19, 2017 (HealthDay News) -- Although breast milk is still considered the best nutrition for babies, ...

  20. Don't Forget Child Safety When Traveling for The Holidays

    MedlinePlus

    ... 7 parents of toddlers don't bring a car seat for travel rides, poll finds To use ... safety measures, making sure toddlers are always in car seats and that medications and cleaning supplies are ...

  1. STS-42 Pilot Oswald dons CCA prior to egress exercises in JSC's WETF pool

    NASA Technical Reports Server (NTRS)

    1991-01-01

    STS-42 Discovery, Orbiter Vehicle (OV) 103, Pilot Stephen S. Oswald, wearing a launch and entry suit (LES), dons his communications carrier assembly (CCA) prior to launch emergency egress (bailout) exercises in JSC's Weightless Environment Training Facility (WETF) Bldg 29.

  2. The Question of Family Homeostasis, with Homage to Don D. Jackson.

    ERIC Educational Resources Information Center

    Jackson, Don D.; Zuk, Gerald H., Ed.

    1981-01-01

    A reprinting of Don D. Jackson's classic 1957 article on family homeostasis, with an homage to the author. Considers certain theoretical aspects of family interactional patterns and how they relate to therapy. (Author/RC)

  3. Have a Baby or Young Child With a Cold? Most Don't Need Medicines

    MedlinePlus

    ... With a Cough or Cold Don't Need Medicines Share Tweet Linkedin Pin it More sharing options ... the correct dose. Giving the Right Dose of Medicine “It’s easy to make errors with liquid medications. ...

  4. The Question of Family Homeostasis, with Homage to Don D. Jackson.

    ERIC Educational Resources Information Center

    Jackson, Don D.; Zuk, Gerald H., Ed.

    1981-01-01

    A reprinting of Don D. Jackson's classic 1957 article on family homeostasis, with an homage to the author. Considers certain theoretical aspects of family interactional patterns and how they relate to therapy. (Author/RC)

  5. Tackling fever and inflammation of unknown origin: the do's and don'ts.

    PubMed

    Vanderschueren, S; Knockaert, D

    2014-12-01

    Fever and inflammation of unknown origin continue to challenge the clinician. The differential diagnosis is broad and potential diagnostic pitfalls abound. To guide the approach, the authors discuss the do's and don'ts.

  6. 2 of 3 Americans Don't Have 'Advance Directive' for End of Life

    MedlinePlus

    ... Videos & Tools About MedlinePlus Search Search MedlinePlus GO GO About ... 2 of 3 Americans Don't Have 'Advance Directive' for End of Life Document lets family members know your wishes To use the ...

  7. Pilot Fullerton dons EES anti-gravity suit lower torso on middeck

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Pilot Fullerton dons ejection escape suit (EES) anti-gravity (anti-g) suit lower torso on forward port side middeck above potable water tank. Anti-g suit is an olive drab inner garment that complements EES.

  8. Don Juan Basin, Wright Valley, Antarctica: Model for Surface Processes on Mars

    NASA Astrophysics Data System (ADS)

    Englert, P.; Bishop, J. L.; Gibson, E. K.; Patel, S.; Koeberl, C.

    2014-09-01

    Mineral, chemical, and soluble salt composition of drill core samples from Don Juan Basin, Wright Valley, Antarctica, indicate that the formation of the most saline terrestrial pond may include groundwater discharge and near surface flow processes.

  9. Got the HPV Vaccine Before You Knew You Were Pregnant? Don't Worry

    MedlinePlus

    ... gov/news/fullstory_164345.html Got the HPV Vaccine Before You Knew You Were Pregnant? Don't ... 29, 2017 (HealthDay News) -- The cancer-preventing HPV vaccine does not appear to have any ill effect ...

  10. Don't Sweat It: Gender Doesn't Dictate Perspiration Rate

    MedlinePlus

    ... gov/news/fullstory_163782.html Don't Sweat It: Gender Doesn't Dictate Perspiration Rate Instead, your ... in conditions where the body can successfully regulate its temperature," Notley said in a journal news release. ...

  11. A Reminder That Meds and Grapefruit Don't Always Mix

    MedlinePlus

    ... html A Reminder That Meds and Grapefruit Don't Always Mix Could be a dangerous combination, depending ... antihistamines, such as Allegra (fexofenadine). Grapefruit juice doesn't affect all drugs in the listed categories. And, ...

  12. Many People Don't Take Their High Blood Pressure Meds

    MedlinePlus

    ... 163928.html Many People Don't Take Their High Blood Pressure Meds: Study Failure to follow doctors' orders leads ... 20 percent of patients seeking care for stubborn high blood pressure take all the medicine they're supposed to, ...

  13. Don't Bank on Heart-Rate Accuracy from Your Activity Tracker

    MedlinePlus

    ... medlineplus.gov/news/fullstory_164546.html Don't Bank on Heart-Rate Accuracy From Your Activity Tracker ... or the U.S. Department of Health and Human Services. More Health News on: Exercise and Physical Fitness ...

  14. Heavy metal flows in aquatic systems of the Don and Kuban river deltas

    NASA Astrophysics Data System (ADS)

    Tkachenko, A. N.; Tkachenko, O. V.; Lychagin, M. Yu.; Kasimov, N. S.

    2017-05-01

    This paper presents the calculated heavy metal (Fe, Mn, Zn, Ni, Cu, Cr, Co, Cd, and Pb) flows in suspended and dissolved forms in the main navigable branches of the Don and Kuban river deltas during the low-water period of 2013-2014. This work is based on the data of field studies in which water and suspended matter samples were collected and the turbidity and water discharge in deltas were measured. A quantitative estimate of heavy metal inflows into the deltas of the Don and Kuban rivers is provided. Transformation of flows of suspended and dissolved metal forms from the delta top to the sea edge is discussed. The influence of localities (Rostov-on-Don, Temryuk) on the increase in heavy metal flows downstream is shown, and the heavy metal flows in the deltas of the Don and Kuban rivers are compared.

  15. Many Americans Don't Know How to Handle High Cholesterol

    MedlinePlus

    ... Americans Don't Know How to Handle High Cholesterol Survey found they know it raises heart risks, ... April 11, 2017 (HealthDay News) -- Americans with high cholesterol are well aware of its heart dangers, but ...

  16. Acceptance speech for the 2016 Don Bloch Award from the Collaborative Family Healthcare Association.

    PubMed

    Jacobs, Barry J

    2017-03-01

    Presents the acceptance speech from Dr. Barry Jacobs for the 2016 Don Bloch Award from the Collaborative Family Healthcare Association (CFHA). (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  17. Effects of feeding deoxynivalenol (DON, vomitoxin)-contaminated wheat to female White Leghorn chickens from day old through egg production.

    PubMed

    Kubena, L F; Harvey, R B; Corrier, D E; Huff, W E

    1987-10-01

    White Leghorn chickens one day of age were fed starter and grower diets containing either a control (noncontaminated) wheat diet or a naturally contaminated deoxynivalenol (DON) wheat diet (18 mg DON/kg) from 1 day of age to the onset of egg production. The hens were then placed on their respective layer diets of control wheat or DON-contaminated wheat (18 mg DON/kg) for six 28-day egg production periods. Feeding the DON-contaminated diet did not significantly influence body weights during the growing or the laying phases. Overall, hen-day egg production and egg weights were significantly higher for hens receiving the DON diet. Feeding DON contaminated wheat caused no significant changes in percent shell, albumen height, percent fertility, percent hatch of fertile eggs, percent hatch of eggs set, or weight of chicks at hatch. There were slight, although significant, changes in shell weight and shell thickness and in some serum chemistry values. There were no significant differences in the hematology parameters measured or in prothrombin times. None of the eggs collected from hens fed the control and the DON-contaminated wheat diet contained detectable quantities of DON. Microscopic examination of sections of the liver, kidney, and proventriculus of control and treated hens revealed no unusual histopathology. The results indicate that feeding DON at relatively high levels beginning at 1 day of age and continuing through six egg production periods had only slight effects on the parameters measured.

  18. Geochemical flows of heavy metals in the Don and Kuban Rivers deltas

    NASA Astrophysics Data System (ADS)

    Tkachenko, Oleg; Tkachenko, Anna; Lychagin, Mikhael

    2015-04-01

    Don and Kuban are the two biggest rivers of the Azov sea basin. Deltaic areas of Don and Kuban Rivers have been influenced by agricultural and industry for a long time. A significant amount of heavy metals and biogenic elements comes into the rivers downstream annually. However, in the deltaic areas these geochemical flows are transformed due to changing of the environment conditions, some pollutions are excluded from the flows and accumulated in the deltaic landscapes. In this way Don and Kuban Rivers deltas can be considered as the biogeochemical filters on the way of the heavy metals and biogenic elements flows in to the Azov Sea. The paper presents the results of the heavy metals flows investigation in the Don and Kuban Rivers deltas. This investigation is based on the field studies of the water flow and sediment load distributions and heavy metals (Fe, Mn, Zn, Cu, Cd, Ni, Cr, Co, Pb) content in the water and suspended matter of the deltas. Quantities arriving of heavy metals in the delta apex in the low water period are calculated; seasonal patterns of flows are considered. Is shown that greater number of heavy metals flow into the delta during the flood period, especially with respect to the dissolved forms of zinc and copper; it is also shown a significant increase of the heavy metals flows downstream of the large cities (Rostov-on-Don, Azov, Temryuk). All these facts indicate anthropogenic impact on the heavy metals inflow. In comparing the heavy metals flow in the Don and Kuban Rivers deltas investigated that Don River flows is an order of magnitude greater than the Kuban River flows. When it comes about the structure of the flows, shown that Don River characterized increased content of dissolved form of heavy metals; Kuban River originates in the Caucasus Mountains so the proportion of suspended forms is higher.

  19. Factors Controlling Dissolved Organic Carbon (DOC) and Nitrogen (DON) Dynamics in Watersheds

    NASA Astrophysics Data System (ADS)

    Inamdar, S.; Finger, N.; Mitchell, M.

    2008-12-01

    Our previous work in a glaciated, forested watershed in western New York revealed distinct differences in the responses of DOC and DON during storm events. We explored if these differences also occurred at an unglaciated, forested, 12 ha watershed in the Piedmont physiographic province of Maryland. Key questions that we addressed are: What are the sources and flowpaths for DOC and DON in the watershed? Do they differ for DOC and DON? Does DOM quality influence the concentrations and transport of DOC and DON? Watershed sources that are being sampled include: rainfall, throughfall, litter, soil water groundwater, hillslope seeps and hyporheic zone water. Watershed sources are sampled manually during non-storm periods (every two weeks) while automated samplers are used for storm events. Water samples are analyzed for all cations, anions, DOC, DON, Silica and O18. DOM quality is characterized using specific ultraviolet absorbance (SUVA), Fluorescence Index (FI), Excitation-Emission Matrices (EMMs), hydrophobic and hydrophilic fractions, and concentrations of phenols, carboxylic acids, flavanoids, and amino acids. Hydrologic monitoring includes discharge and groundwater elevations. Our initial results suggest that differences in DOC and DON are not as large as that observed for the western New York site. Endmember mixing analysis (EMMA) indicates that stream chemistry is regulated by seep runoff, litter, and riparian soil water with individual endmember contributions varying with size of the storm events and wetness conditions. Highest DOC and DON concentrations were recorded for throughfall and litter layer. SUVA values were highest and most variable for litter leachate followed by riparian water. Concentrations of DOC and DON in streamflow increased dramatically during events and peaked at or after the discharge peak. While SUVA values followed a similar trend, there were slight differences among events. Additional relationships between DOM concentrations and quality

  20. Rare Earth Element Concentrations from Wells at the Don A. Campbell Geothermal Plant, Nevada

    DOE Data Explorer

    Fowler, Andrew; Zierenberg, Robert

    2016-12-09

    * Requires permission of originators for use. Rare earth element concentrations in thermal springs from the wells at the Don A. Campbell geothermal plant, Nevada. Samples taken from geothermal wells 85-11, 65-11, 54-11, and 64-11. Includes pH and concentrations for Cerium, Dysprosium, Erbium, Europium, Gadolinium, Holmium, Lanthanum, Lutetium, Neodymium, Praseodymium, Samarium, Terbium, Thulium, Yttrium, and Ytterbium. Samples from Don A. Campbell, Nevada collected on October 14, 2016.

  1. Mixing regime as a key factor to determine DON formation in drinking water biological treatment.

    PubMed

    Lu, Changqing; Li, Shuai; Gong, Song; Yuan, Shoujun; Yu, Xin

    2015-11-01

    Dissolved organic nitrogen (DON) can act as precursor of nitrogenous disinfection by-products formed during chlorination disinfection. The performances of biological fluidized bed (continuous stirred tank reactor, CSTR) and bio-ceramic filters (plug flow reactor, PFR) were compared in this study to investigate the influence of mixing regime on DON formation in drinking water treatment. In the shared influent, DON ranged from 0.71mgL(-1) to 1.20mgL(-1). The two biological fluidized bed reactors, named BFB1 (mechanical stirring) and BFB2 (air agitation), contained 0.12 and 0.19mgL(-1) DON in their effluents, respectively. Meanwhile, the bio-ceramic reactors, labeled as BCF1 (no aeration) and BCF2 (with aeration), had 1.02 and 0.81mgL(-1) DON in their effluents, respectively. Comparative results showed that the CSTR mixing regime significantly reduced DON formation. This particular reduction was further investigated in this study. The viable/total microbial biomass was determined with propidium monoazide quantitative polymerase chain reaction (PMA-qPCR) and qPCR, respectively. The results of the investigation demonstrated that the microbes in BFB2 had higher viability than those in BCF2. The viable bacteria decreased more sharply than the total bacteria along the media depth in BCF2, and DON in BCF2 accumulated in the deeper media. These phenomena suggested that mixing regime determined DON formation by influencing the distribution of viable, total biomass, and ratio of viable biomass to total biomass. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Science 101: Why Don't Spiders Stick to Their Own Webs?

    ERIC Educational Resources Information Center

    Robertson, Bill

    2011-01-01

    This article explains why spiders don't stick to their webs. Spiders don't get stuck in their own webs (and they aren't immune to their own glue) because they use a combination of sticky and nonsticky threads (different glands for producing those), and the glue is in droplets that the spider can avoid but the prey can't. The spider's nervous…

  3. Science 101: Why Don't Spiders Stick to Their Own Webs?

    ERIC Educational Resources Information Center

    Robertson, Bill

    2011-01-01

    This article explains why spiders don't stick to their webs. Spiders don't get stuck in their own webs (and they aren't immune to their own glue) because they use a combination of sticky and nonsticky threads (different glands for producing those), and the glue is in droplets that the spider can avoid but the prey can't. The spider's nervous…

  4. Simultaneous colour and DON removal from sewage treatment plant effluent: alum coagulation of melanoidin.

    PubMed

    Dwyer, Jason; Griffiths, Peter; Lant, Paul

    2009-02-01

    The aim of this study was to detect and characterise melanoidin in sewage treatment plant (STP) effluent, and to study the ability of alum coagulation to remove the colour and dissolved organic nitrogen (DON) associated with melanoidin. The melanoidin is non-biodegradable due to the complex cyclic based structure and thus it directly contributes to effluent nitrogen concentrations from the sewage treatment plant (STP). Lowering of effluent total nitrogen limits and the link between colour and chlorinated disinfection by-products have therefore driven a need to understand the structure, properties and treatability of DON species found in STP effluent. The focus of this paper is the refractory coloured, organic nitrogen compound melanoidin. Wetalla STP effluent has relatively high colour (170mg-PtCoL(-1)) and DON (2.5mgL(-1)) for a biological nutrient removal STP, owing to an industrial supply of melanoidin containing molasses fermentation wastewater. Alum coagulation jar tests were performed on synthetic melanoidin solution, STP effluent containing melanoidin (Wetalla, Toowoomba, Australia) and STP effluent free of melanoidin (Merrimac, Gold Coast, Australia) to examine the treatability of melanoidin and its associated colour and DON content when present in STP effluent. The removal of melanoidin from STP effluent resulted in significant colour and DON reduction. An alum dose of 30mgL(-1) as aluminium was sufficient to reach maximum removal of colour (75%), DON (42%) and dissolved organic carbon (DOC) (30%) present in melanoidin containing STP effluent. Alum was shown to preferentially remove DON with a molecular weight >10kDa over small molecular weight DON. Fluorescence excitation-emission matrix examination of the humic compounds present in the STP effluent indicated that melanoidin type humic compounds were more readily removed by alum coagulation than other humic compounds.

  5. Flagellar mitochondrial association of the male-specific Don Juan protein in Drosophila spermatozoa.

    PubMed

    Santel, A; Blümer, N; Kämpfer, M; Renkawitz-Pohl, R

    1998-11-01

    The Drosophila don juan gene encodes a basic protein (Don Juan protein), which is solely expressed postmeiotically during spermiogenesis in elongated spermatids and in mature sperm. Transgenic expression of a GFP-tagged Don Juan protein (DJ-GFP) in the male germ line showed an association of the fusion protein with the sperm tail. Detailed examination of DJ-GFP localization revealed novel insights into its distinct temporal and spatial distribution along the sperm tail during the last phase of spermatid maturation. Co-localization of DJ-GFP with actin-labeled cysts demonstrated its emergence in elongated spermatids during individualization. Additionally, the endogenous Don Juan protein was detected with epitope-specific antibodies in finally elongated nuclei of spermatids. After completion of nuclear shaping Don Juan is no longer detectable in the sperm heads with the onset of individualization. Mislocalization of the DJ-GFP protein in flagella of a mutant with defective mitochondrial differentiation provides evidence of mitochondrial association of the fusion protein with flagellar mitochondrial arrays. Ectopically expressed DJ-GFP in premeiotic germ cells as well as salivary gland cells confirmed the capability of the fusion protein to associate with mitochondria. Therefore we suppose that Don Juan is a nuclear-encoded, germ-cell specifically expressed mitochondrial protein, which might be involved in the final steps of mitochondrial differentiation within the flagellum.

  6. In vivo effects of deoxynivalenol (DON) on innate immune responses of carp (Cyprinus carpio L.).

    PubMed

    Pietsch, Constanze; Michel, Christian; Kersten, Susanne; Valenta, Hana; Dänicke, Sven; Schulz, Carsten; Kloas, Werner; Burkhardt-Holm, Patricia

    2014-06-01

    Deoxynivalenol (DON) is one of the most important members of Fusarium toxins since it often can be found in relevant concentrations in animal feeds. The effects of this group of toxins on fish are mostly unknown. The present study shows results from a feeding trial with carp (Cyprinus carpio L.) using three different concentrations of DON (352μgkg(-1), 619μgkg(-1), and 953μgkg(-1) final feed, respectively) which are comparable to levels found in commercial fish feeds. Effects on growth and mass of fish were not observed during this 6weeks lasting experiment. Only marginal DON concentrations were found in muscle and plasma samples. Blood parameters were not influenced although smaller erythrocytes occurred in fish treated with 352μgkg(-1) DON. Analysis of antioxidative enzymes in erythrocytes showed increased superoxid dismutase and catalase activities in fish fed the low-dose feed. Immunosuppressive effects of DON were confirmed whereby cytotoxic effects on immune cells only partly explained the impairment of innate immune responses. Exact polarization of the immune system into pro-inflammatory or anti-inflammatory responses due to DON exposure should be clarified in further experiments, especially since the current results raise concern about impaired immune function in fish raised in aquaculture. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. AL Amyloidosis

    PubMed Central

    2012-01-01

    Definition of the disease AL amyloidosis results from extra-cellular deposition of fibril-forming monoclonal immunoglobulin (Ig) light chains (LC) (most commonly of lambda isotype) usually secreted by a small plasma cell clone. Most patients have evidence of isolated monoclonal gammopathy or smoldering myeloma, and the occurrence of AL amyloidosis in patients with symptomatic multiple myeloma or other B-cell lymphoproliferative disorders is unusual. The key event in the development of AL amyloidosis is the change in the secondary or tertiary structure of an abnormal monoclonal LC, which results in instable conformation. This conformational change is responsible for abnormal folding of the LC, rich in β leaves, which assemble into monomers that stack together to form amyloid fibrils. Epidemiology AL amyloidosis is the most common type of systemic amyloidois in developed countries with an estimated incidence of 9 cases/million inhabitant/year. The average age of diagnosed patients is 65 years and less than 10% of patients are under 50. Clinical description The clinical presentation is protean, because of the wide number of tissues or organs that may be affected. The most common presenting symptoms are asthenia and dyspnoea, which are poorly specific and may account for delayed diagnosis. Renal manifestations are the most frequent, affecting two thirds of patients at presentation. They are characterized by heavy proteinuria, with nephrotic syndrome and impaired renal function in half of the patients. Heart involvement, which is present at diagnosis in more than 50% of patients, leading to restrictive cardiopathy, is the most serious complication and engages prognosis. Diagnostic methods The diagnosis relies on pathological examination of an involved site showing Congo red-positive amyloid deposits, with typical apple-green birefringence under polarized light, that stain positive with an anti-LC antibody by immunohistochemistry and/or immunofluorescence. Due to the

  8. Measurements of dissolved organic nitrogen (DON) in water samples with nanofiltration pretreatment.

    PubMed

    Xu, Bin; Li, Da-Peng; Li, Wei; Xia, Sheng-Ji; Lin, Yi-Li; Hu, Chen-Yan; Zhang, Cao-Jie; Gao, Nai-Yun

    2010-10-01

    Dissolved organic nitrogen (DON) measurements for water samples with a high dissolved inorganic nitrogen (DIN, including nitrite, nitrate and ammonia) to total dissolved nitrogen (TDN) ratio using traditional methods are inaccurate due to the cumulative analytical errors of independently measured nitrogen species (TDN and DIN). In this study, we present a nanofiltration (NF) pretreatment to increase the accuracy and precision of DON measurements by selectively concentrating DON while passing through DIN species in water samples to reduce the DIN/TDN ratio. Three commercial NF membranes (NF90, NF270 and HL) were tested. The rejection efficiency of finished water from the Yangshupu drinking water treatment plant (YDWTP) is 12%, 31%, 8% of nitrate, 26%, 28%, 23% of ammonia, 77%, 78%, 82% of DOC (dissolved organic carbon), and 83%, 87% 88% of UV(254) for HL, NF90 and NF270, respectively. NF270 showed the best performance due to its high DIN permeability and DON retention (∼80%). NF270 can lower the DIN/TDN ratio from around 1 to less than 0.6 mg N/mg N, and satisfactory DOC recoveries as well as DON measurements in synthetic water samples were obtained using optimized operating parameters. Compared to the available dialysis pretreatment method, the NF pretreatment method shows a similar improved performance for DON measurement for aqueous samples and can save at least 20 h of operating time and a large volume of deionized water, which is beneficial for laboratories involved in DON analysis. DON concentration in the effluent of different treatment processes at the YDWTP and the SDWTP (Shijiuyang DWTP) in China were investigated with and without NF pretreatment; the results showed that DON with NF pretreatment and DOC both gradually decreased after each water treatment process at both treatment plants. The advanced water treatment line, including biological pretreatment, clarification, sand filtration, ozone-BAC processes at the SDWTP showed greater efficiency of DON

  9. Increasing trends of dissolved organic nitrogen (DON) in temperate forests under recovery from acidification in Flanders, Belgium.

    PubMed

    Verstraeten, Arne; Verschelde, Pieter; De Vos, Bruno; Neirynck, Johan; Cools, Nathalie; Roskams, Peter; Hens, Maarten; Louette, Gerald; Sleutel, Steven; De Neve, Stefaan

    2016-05-15

    We evaluated trends (2005-2013) and patterns of dissolved organic nitrogen (DON) and its ratio with dissolved organic carbon (DOC), DOC:DON in atmospheric deposition and soil solution of five Level II plots of the International Co-operative Programme on Assessment and Monitoring of Air Pollution Effects on Forests (ICP Forests) in Flanders, Northern Belgium. The primary aim was to confirm positive postulated trends in DON levels and DOC:DON under on-going recovery from acidification. The DON concentrations (0.95-1.41 mg L(-1)) and fluxes (5.6-8.3 kg ha(-1)y(-1)) in throughfall were about twice as high compared to precipitation in the open field (0.40-0.48 mg L(-1), 3.0-3.9 kg ha(-1)y(-1)). Annual soil profile leaching losses of DON varied between 1.2 and 3.7 kg ha(-1)y(-1). The highest soil DON concentrations and fluxes were observed beneath the O horizon (1.84-2.36 mg L(-1), 10.1-12.3 kg ha(-1)y(-1)). Soil solution concentrations and fluxes of DON showed significant increasing trends. Temporarily soil solution DOC:DON rose following an exceptionally long spring drought in 2007, suggesting an effect of drying and rewetting on DOM composition. Further research is needed to test the dependence of DON and DOC:DON on factors such as latitude, forest cover, length of the growing season, hydrology and topography. Nonetheless, even with considerable variation in soil type, level of base saturation, and soil texture in the five included ICP Forests Level II plots, all data revealed a proportionally larger positive response of DON flux than DOC to recovery from acidification.

  10. Authority as paradox: the transformations of Don Quijote.

    PubMed

    Priel, Beatriz

    2006-12-01

    The author's contention is that the analysand's temporary attribution of authority to the analyst is inherent in the analytic situation; this is seen as a transitional and paradoxical form of authority pertaining neither to internal nor external reality, but dwelling in the analytic third. The author proposes a conceptualization of psychoanalytic authority as a form of aesthetic authority according to Gadamer's definitions. While the scientific and hermeneutic codes for the understanding of authority in psychoanalysis assume that the main issue at stake is the delimitation of the objectivity or the subjectivity of the analyst's knowledge, this aesthetic perspective centres on the analysand's attribution of a claim of truth to analytic interpretations, and on the experience of recognition. The experience of recognition of a possible truth is particular and context-bound, as well as self-transformational. A reading of three episodes from Cervantes's The history of Don Quixote de la Mancha illuminates the transitional and paradoxical character of aesthetic authority within a transformational dialogue. These episodes are read as dramatizations of different positions vis-à-vis the paradoxical authority that characterizes transformational dialogues.

  11. Why change programs don't produce change.

    PubMed

    Beer, M; Eisenstat, R A; Spector, B

    1990-01-01

    Faced with changing markets and tougher competition, more and more companies realize that to compete effectively they must transform how they function. But while senior managers understand the necessity of change, they often misunderstand what it takes to bring it about. They assume that corporate renewal is the product of company-wide change programs and that in order to transform employee behavior, they must alter a company's formal structure and systems. Both these assumptions are wrong, say these authors. Using examples drawn from their four-year study of organizational change at six large corporations, they argue that change programs are, in fact, the greatest obstacle to successful revitalization and that formal structures and systems are the last thing a company should change, not the first. The most successful change efforts begin at the periphery of a corporation, in a single plant or division. Such efforts are led by general managers, not the CEO or corporate staff people. And these general managers concentrate not on changing formal structures and systems but on creating ad hoc organizational arrangements to solve concrete business problems. This focuses energy for change on the work itself, not on abstractions such as "participation" or "culture." Once general managers understand the importance of this grass-roots approach to change, they don't have to wait for senior management to start a process of corporate renewal. The authors describe a six-step change process they call the "critical path."

  12. Risk Acceptance Personality Paradigm: How We View What We Don't Know We Don't Know

    NASA Technical Reports Server (NTRS)

    Massie, Michael J.; Morris, A. Terry

    2011-01-01

    The purpose of integrated hazard analyses, probabilistic risk assessments, failure modes and effects analyses, fault trees and many other similar tools is to give managers of a program some idea of the risks associated with their program. All risk tools establish a set of undesired events and then try to evaluate the risk to the program by assessing the severity of the undesired event and the likelihood of that event occurring. Some tools provide qualitative results, some provide quantitative results and some do both. However, in the end the program manager and his/her team must decide which risks are acceptable and which are not. Even with a wide array of analysis tools available, risk acceptance is often a controversial and difficult decision making process. And yet, today's space exploration programs are moving toward more risk based design approaches. Thus, risk identification and good risk assessment is becoming even more vital to the engineering development process. This paper explores how known and unknown information influences risk-based decisions by looking at how the various parts of our personalities are affected by what they know and what they don't know. This paper then offers some criteria for consideration when making risk-based decisions.

  13. Tour by Saudi prince Salman Abdelazize Al-Saud prior to mission

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Tour by Saudi prince Salman Abdelazize Al-Saud, payload specialists for STS 51-G mission, prior to mission. Al-Saud and Abdulmohsen Hamad Al-Bassam, the backup payload specialist, man the controls on the flight deck of the crew compartment trainer in the Shuttle mockup and integration laboratory (29788); the Saudi payload specialists share the hatch of the crew compartment trainer (29789); Portrait view of Abdulmohsen Hamad Al-Bassam during a visit to the Shuttle mockup and integraion laboratory (29790); Don Sirroco, left, explains the middeck facilities in the Shuttle mockup and integration laboratory (29791); Portrait view of Sultan Salman Abdelazize Al-Saud in the Shuttle Mockup and Integration laboratory (29792); The Saudi payload specialists witness a space food demonstration in the life sciences laboratory at JSC. Al-Saud (left) and Al-Bassam (second left) listen as Rita M. Rapp, food specialist, discusses three preparations of re-hydratable food for space travelers. Lynn S. Coll

  14. Dissolved organic nitrogen (DON) profile during backwashing cycle of drinking water biofiltration.

    PubMed

    Liu, Bing; Gu, Li; Yu, Xin; Yu, Guozhong; Zhang, Huining; Xu, Jinli

    2012-01-01

    A comprehensive investigation was made in this study on the variation of dissolved organic nitrogen (DON) during a whole backwashing cycle of the biofiltration for drinking water treatment. In such a cycle, the normalized DON concentration (C(effluent)/C(influent)) was decreased from 0.98 to 0.90 in the first 1.5h, and then gradually increased to about 1.5 in the following 8h. Finally, it remained stable until the end of this 24-hour cycle. This clearly 3-stage profile of DON could be explained by three aspects as follows: (1) the impact of the backwashing on the biomass and the microbial activity; (2) the release of soluble microbial products (SMPs) during the biofiltration; (3) the competition between heterotrophic bacteria and nitrifying bacteria. All the facts supported that more DON was generated during later part of the backwashing cycle. The significance of the conclusion is that the shorter backwashing intervals between backwashing for the drinking water biofilter should further decrease the DON concentration in effluent of biofilter.

  15. Sensitive method for determination of DON in cocoa by means of HPLC-techniques.

    PubMed

    Raters, M; Matissek, R

    2007-12-01

    The mycotoxin deoxynivalenol (DON) is one of a group of mycotoxins known as type B trichothecenes and is particularly formed by the mould speciesFusarium graminearum andFusarium culmorum. The frequency of the occurrence of DON in certain raw materials and the concentrations found make it one of the world's most significant mycotoxin contaminants. Positive findings of the toxin especially have been established in cereal-based foods, as well as in oilseeds.The main objective of this study was to set up a current situation assessment of the possible occurrence of deoxynivalenol in cocoa and cocoa products. As there was no analytical method for determining DON in cocoa and cocoa products, a special method was developed. The applicability and consistency of the method was confirmed by performing recovery assays on various cocoa products. A special post-column derivatisation procedure was developed to increase selectivity and raise sensitivity by a factor of 80.The method was used to test 230 samples for possible DON content, ranging from cocoa beans to cocoa bean shells, nibs, cocoa liquor and cocoa powders through to finished cocoa-based products. The results suggest that DON may occasionally occur in cocoa beans in very low concentrations.

  16. Why teams don't work. Interview by Diane Coutu.

    PubMed

    Hackman, J Richard

    2009-05-01

    The belief that teams make us more creative and productive--and are the best way to get things done--is deeply entrenched. But Hackman, a professor of organizational psychology at Harvard and a leading expert on teams, is having none of it. Research, he says, consistently shows that teams underperform despite all their extra resources. In an interview with senior editor Diane Coutu, Hackman explains where teams go wrong. Shockingly, most of the time members don't agree on what the team is supposed to be doing or even on who is on the team. The belief that bigger is better also compounds problems; as a team grows, the effort needed to manage links between members increases almost exponentially. Leaders need to be ruthless about defining teams and keeping them small (fewer than 10 members), and some individuals (like team destroyers) should simply be forced off. The leader also must set a compelling direction for the team--but in so doing, may encounter intense resistance that puts him or her at great risk. Hackman explores other fallacies about teams--for instance, that teams whose members have been together a long time become stale. In fact, research reveals that new teams make 50% more mistakes than established teams. To avoid complacency, though, every team needs a deviant--someone who is willing to make waves and open up the group to more ideas. Unfortunately, such individuals often get thrown off the team, robbing it of its chance to be magical. Leaders can't make a team do well. However, by being disciplined about how a team is set up and managed, instituting the right support systems, and providing coaching in group processes, they can increase the likelihood that a team will be great.

  17. Effect of fermentation on naturally occurring deoxynivalenol (DON) in Argentinean bread processing technology.

    PubMed

    Samar, M M; Neira, M S; Resnik, S L; Pacin, A

    2001-11-01

    The stability of naturally occurring DON was evaluated during the fermentation stage of the bread-making process on a pilot scale. Two different products, French bread and Vienna bread, were prepared with naturally contaminated wheat flour (150 mg kg(-1)) under controlled experimental conditions. Dough was fermented at 30, 40 and 50 degrees C according to standard procedures employed in Argentinean low-technology bakeries. When the dough was fermented at 50 degrees C, the maximum reduction was 56% for the Vienna bread, with French bread being reduced by 41%. DON reduction during bread-making occurs not only in the baker due to thermal decomposition, but also during the fermentation step. The Argentinean traditional bread-making process might reduce DON levels during the fermentation stages if the dough is leavened at temperatures > 30 degrees C.

  18. Evaluation on levels and conversion profiles of DON, 3-ADON, and 15-ADON during bread making process.

    PubMed

    Wu, Li; Wang, Bujun

    2015-10-15

    The present study investigated the changes and conversion profiles of DON, its conjugations 3-ADON, and 15-ADON during bread making process, by spiking targeted mycotoxin standards to Fusarium mycotoxins-free wheat flour. No significant (p < 0.05) changes of DON levels were observed during dough preparation stages, including kneading, fermentation, and proofing. A reduction of DON level ranged from 4% to 14% was observed during baking process. The main thermal degradation products of DON, namely norDON A, B, C, and F were detected in the bread crust. Regarding ADONs, decreases of 20-40% for 3-ADON and 28-60% for 15-ADON were found during fermentation stage, and further losses of ADONs were observed after proofing process. Although ADONs levels gained an increase after baking. This study demonstrated that ADONs were converted to DON, while no ADONs were detectable in DON spiked samples during bread making process. The mechanism that ADONs could be converted into DON is unclear so far. Copyright © 2015. Published by Elsevier Ltd.

  19. 75 FR 8106 - Don Edwards San Francisco Bay National Wildlife Refuge, Alameda, Santa Clara, and San Mateo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... Fish and Wildlife Service Don Edwards San Francisco Bay National Wildlife Refuge, Alameda, Santa Clara... located in Alameda, Santa Clara, and San Mateo Counties of California. We provide this notice in..., we initiate our process for developing a CCP for Don Edwards San Francisco Bay NWR in Alameda,...

  20. Evaluation of genetic toxicity of 6-diazo-5-oxo-l-norleucine (DON).

    PubMed

    Kulkarni, Rohan M; Dakoulas, Emily W; Miller, Ken E; Terse, Pramod S

    2017-09-01

    DON (6-diazo-5-oxo-l-norleucine), a glutamine antagonist, was demonstrated to exhibit analgesic, antibacterial, antiviral and anticancer properties. The study was performed to characterize its in vitro and in vivo genetic toxicity potential. DON was tested in the bacterial reverse mutation assay (Ames test) using Salmonella typhimurium tester strains (TA98, TA100, TA1535 and TA1537) and Escherichia coli tester strain (WP2 uvrA) with and without S9 and also with reductive S9. In addition, DON was tested for the chromosome aberrations in Chinese hamster ovary (CHO) cells with or without S9 to evaluate the clastogenic potential. Furthermore, DON was also evaluated for its in vivo clastogenic activity by detecting micronuclei in polychromatic erythrocyte (PCE) cells in bone marrow collected from the male mice dosed intravenously with 500, 100, 10, 1 and 0.1 mg/kg at 24 and 48-h post-dose. The Ames mutagenicity assay showed no positive mutagenic responses. However, the in vitro chromosome aberration assay demonstrated dose dependent statistically positive increase in structural aberrations at 4 and 20-h exposure without S9 and also at 4-h exposure with S9. The in vivo micronucleus assay also revealed a statistically positive response for micronucleus formation at 500, 100 and 10 mg/kg at 24 and 48-h post-dose. Thus, DON appears to be negative in the Ames test but positive in the in vitro chromosome aberration assay and in the in vivo micronucleus assay. In conclusion, the results indicate DON is a genotoxic compound with a plausible epigenetic mechanism.

  1. Individual and combined effects of aflatoxin and deoxynivalenol (DON, vomitoxin) in broiler chickens.

    PubMed

    Huff, W E; Kubena, L F; Harvey, R B; Hagler, W M; Swanson, S P; Phillips, T D; Creger, C R

    1986-07-01

    The individual and combined effects of aflatoxin and deoxynivalenol (DON) were evaluated in young broiler chickens (Hubbard X Hubbard). The experimental design was a 2 X 2 factorial with treatments of 0 and 2.5 micrograms of aflatoxin/g of feed (ppm) and 0 and 16 micrograms of DON/g of feed. The broilers were maintained on these dietary treatments from hatching to 3 weeks of age in electrically heated batteries with feed and water available ad libitum. The aflatoxin treatment significantly (P less than .05) decreased body weight; weight gain; increased the relative weight of the spleen, liver, and kidney; induced hepatic hyperlipemia; decreased activity of lactic dehydrogenase; and decreased serum levels of protein, albumin, and phosphorus. The toxicity of DON was expressed through reduced growth rate, increased feed conversion; increased relative weight of the gizzard, anemia, decreased activity of lactic dehydrogenase, and decreased serum triglycerides. The interaction between aflatoxin and DON was characterized by reduced growth rates; increased feed conversion, increased relative weight of the proventriculus, gizzard, spleen, liver, and kidney, anemia, hepatic hyperlipemia, decreased activity of alkaline phosphatase, glutamic oxalacetic transaminase, and lactic dehydrogenase, and decreased serum levels of protein, albumin, uric acid, cholesterol, triglycerides, and calcium. These data demonstrate that both aflatoxin and DON can limit broiler performance and adversely effect broiler health. The effects of the combination of aflatoxin and DON on broiler performance and health was more severe than the individual effects of these mycotoxins; however, the interaction was not severe enough to represent toxic synergy and can best be characterized as additive toxicity.

  2. RICKETS AT THE MEDICI COURT OF FLORENCE: THE CASE OF DON FILIPPINO (1577-1582).

    PubMed

    Castagna, Maura; Giuffra, Valentina; Fattori, Silvia; Vitiello, Angelica; Caramella, Davide; Giustini, Davide; Fornaciari, Gino

    2014-01-01

    Among the children found in the crypt of the Grand Duke Giangastone in S. Lorenzo Basilica (Florence), the skeletal remains of a 5-year-old child still wearing his fine high social status clothing were recovered. This child of the Medici family was identified as Don Filippino (1577-1582), son of the Grand Duke Francesco I (1541-1587) and Giovanna from Austria (1547 - 1578). The prince showed several pathological deformities of the cranial and post-cranial skeleton, including enlargement of the cranium, thinning of the cranial vault bones (craniotabes), platybasia and marked bending of femora, tibiae and fibulae. Differential diagnosis suggests that Don Filippino was affected by rickets. The occurrence of this metabolic disease related to vitamin D deficiency in a Renaissance high social class individual can be explained by the practice of very prolonged breast-feeding, up until two years of age. Maternal milk contains insufficient vitamin D ratios and retarded weaning severely exposes children to a higher risk of developing rickets, especially if dietary habits are combined with inadequate exposure to sunlight. Historical sources describe Don Filippino as frail and sickly, with frequent illnesses and persistent slight fevers, and it can be supposed that the child was frequently confined indoors, especially in the cold season. Integration of osteoarchaeological evidence with historical documentation suggests that bone lesions observed in the skeletal remains of Don Filippino are compatible with a diagnosis of rickets, caused by the custom of prolonged breast-feeding associated with inadequate sunlight exposure to sunlight. Historical sources describe Don Filippino as frail and sickly, with frequent illnesses and persistent slight fevers, and it can be supposed that the child was frequently confined indoors, especially in the cold season. Integration of osteoarchaeological evidence with historical documentation suggests that bone lesions observed in the skeletal

  3. The discovery of cometary activity in near-Earth asteroid (3552) Don Quixote

    SciTech Connect

    Mommert, Michael; Harris, Alan W.; Hora, Joseph L.; Smith, Howard A.; Reach, William T.; Emery, Joshua P.; Thomas, Cristina A.; Mueller, Michael; Cruikshank, Dale P.; Trilling, David E.; Delbo, Marco

    2014-01-20

    The near-Earth object (NEO) population, which mainly consists of fragments from collisions between asteroids in the main asteroid belt, is thought to include contributions from short-period comets as well. One of the most promising NEO candidates for a cometary origin is near-Earth asteroid (3552) Don Quixote, which has never been reported to show activity. Here we present the discovery of cometary activity in Don Quixote based on thermal-infrared observations made with the Spitzer Space Telescope in its 3.6 and 4.5 μm bands. Our observations clearly show the presence of a coma and a tail in the 4.5 μm but not in the 3.6 μm band, which is consistent with molecular band emission from CO{sub 2}. Thermal modeling of the combined photometric data on Don Quixote reveals a diameter of 18.4{sub −0.4}{sup +0.3} km and an albedo of 0.03{sub −0.01}{sup +0.02}, which confirms Don Quixote to be the third-largest known NEO. We derive an upper limit on the dust production rate of 1.9 kg s{sup –1} and derive a CO{sub 2} gas production rate of (1.1 ± 0.1) × 10{sup 26} molecules s{sup –1}. Spitzer Infrared Spectrograph spectroscopic observations indicate the presence of fine-grained silicates, perhaps pyroxene rich, on the surface of Don Quixote. Our discovery suggests that CO{sub 2} can be present in near-Earth space over a long time. The presence of CO{sub 2} might also explain that Don Quixote's cometary nature remained hidden for nearly three decades.

  4. Organ Damage and Hepatic Lipid Accumulation in Carp (Cyprinus carpio L.) after Feed-Borne Exposure to the Mycotoxin, Deoxynivalenol (DON)

    PubMed Central

    Pietsch, Constanze; Schulz, Carsten; Rovira, Pere; Kloas, Werner; Burkhardt-Holm, Patricia

    2014-01-01

    Deoxynivalenol (DON) frequently contaminates animal feed, including fish feed used in aquaculture. This study intends to further investigate the effects of DON on carp (Cyprinus carpio L.) at concentrations representative for commercial fish feeds. Experimental feeding with 352, 619 or 953 μg DON kg−1 feed resulted in unaltered growth performance of fish during six weeks of experimentation, but increased lipid peroxidation was observed in liver, head kidney and spleen after feeding of fish with the highest DON concentration. These effects of DON were mostly reversible by two weeks of feeding the uncontaminated control diet. Histopathological scoring revealed increased liver damage in DON-treated fish, which persisted even after the recovery phase. At the highest DON concentration, significantly more fat, and consequently, increased energy content, was found in whole fish body homogenates. This suggests that DON affects nutrient metabolism in carp. Changes of lactate dehydrogenase (LDH) activity in kidneys and muscle and high lactate levels in serum indicate an effect of DON on anaerobic metabolism. Serum albumin was reduced by feeding the medium and a high dosage of DON, probably due to the ribotoxic action of DON. Thus, the present study provides evidence of the effects of DON on liver function and metabolism. PMID:24566729

  5. STS-26 crewmembers don LESs and CES equipment in JSC WETF Bldg 29

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, crewmembers don newly designed partial pressure suits or launch entry suits (LESs) and crew escape system (CES) equipment during training exercise in JSC Weightless Environment Training Facility (WETF) Bldg 29. For an upcoming rehearsal of the CES pole method of emergency escape from the Space Shuttle, Commander Frederick H. Hauck (standing) adjusts his parachute pack as Pilot Richard O. Covey, in the process of donning his LES, looks on. Technicians prepare for test activities around Hauck and Covey. WETF mockups appear in the background.

  6. Toward Complete Inclusion: Lesbian, Gay, Bisexual, and Transgender Military Service Members after Repeal of Don't Ask, Don't Tell.

    PubMed

    Aford, Brandon; Lee, Shawna J

    2016-07-01

    The 2010 repeal of Don't Ask, Don't Tell (DADT) is one example of how U.S. public policy has shifted toward greater inclusion of lesbian, gay, and bisexual (LGB) individuals. The repeal of DADT reversed the practice of discharging LGB service members on the basis of sexual identity. LGB service members may now serve their country without fear of direct repercussions stemming from sexual identity. Though it is a statutory step toward parity, DADT repeal does not address a number of cultural and institutional inequities that continue to hinder full inclusion of sexual minority service members. Notably, as discussed in this article, DADT largely ignores issues facing the transgender population. This study examines remaining inequities and their ramifications for lesbian, gay, bisexual, and transgender service members and their families. The article concludes with practice and policy recommendations for culturally competent social work practice with military service members across the sexual identity spectrum.

  7. Sherlock Holmes' or Don Quixote`s certainty? Interpretations of cropmarks on satellite imageries in archaeological investigation

    NASA Astrophysics Data System (ADS)

    Wilgocka, Aleksandra; RÄ czkowski, Włodzimierz; Kostyrko, Mikołaj; Ruciński, Dominik

    2016-08-01

    Years of experience in air-photo interpretations provide us to conclusion that we know what we are looking at, we know why we can see cropmarks, we even can estimate, when are the best opportunities to observe them. But even today cropmarks may be a subject of misinterpretation or wishful thinking. The same problems appear when working with aerial photographs, satellite imageries, ALS, geophysics, etc. In the paper we present several case studies based on data acquired for and within ArchEO - archaeological applications of Earth Observation techniques project to discuss complexity and consequences of archaeological interpretations. While testing usefulness of satellite imagery in Poland on various types of sites, cropmarks were the most frequent indicators of past landscapes as well as archaeological and natural features. Hence, new archaeological sites have been discovered mainly thanks to cropmarks. This situation has given us an opportunity to test not only satellite imageries as a source of data but also confront them with results of other non-invasive methods of data acquisition. When working with variety of data we have met several issues which raised problems of interpretation. Consequently, questions related to the cognitive value of remote sensing data appear and should be discussed. What do the data represent? To what extent the imageries, cropmarks or other visualizations represent the past? How should we deal with ambiguity of data? What can we learn from pitfalls in the interpretation of cropmarks, soilmarks etc. to share more Sherlock's methodology rather than run around Don Quixote's delusions?

  8. Stokes IQUV mapping of α2 CVn & other Ap stars using ESPaDOnS and NARVAL

    NASA Astrophysics Data System (ADS)

    Silvester, J.; Kochukhov, O.; Wade, G. A.

    2013-12-01

    New spectral line polarisation observations of 7 bright Ap stars have been obtained with the ESPaDOnS and Narval high resolution spectropolarimeters (Silvester et al. 2012). The aim of this data set is produce a series of surface magnetic field and surface chemistry maps for these Ap stars. We present new magnetic maps for the Ap star α2 CVn using these new data and the MDI inversion code INVERS10. α2 CVn is the first Ap star to be observed during two separate epochs using high resolution phase resolved spectropolarimetric IQUV observations and as such allows us an insight into how stable the surface magnetic structure is over a decade timescale. We show that the new maps give a magnetic field structure consistent with the previous maps obtained by Kochukhov and Wade (2010) from lower quality MuSiCoS spectra taken a decade ago and that the field topology cannot be described by a dipolar or quadrupolar field.

  9. If at First You Don't Succeed ...: A Closer Look at an Old Adage

    ERIC Educational Resources Information Center

    Baskwill, Jane

    2006-01-01

    "If at first you don't succeed, try, try again." This is a well-known adage with which many are familiar. Children learn it from an early age as they begin to walk, ride their bike, or tie their shoes. Adults repeatedly encourage children by saying, "You can do it! Give it a try! Just try harder!" However, when trying harder…

  10. STS-38 Mission Specialist (MS) Carl J. Meade during EMU donning in JSC's WETF

    NASA Technical Reports Server (NTRS)

    1990-01-01

    STS-38 Mission Specialist (MS) Carl J. Meade, wearing extravehicular mobility unit (EMU) upper torso, takes a breather from suit donning activities in JSC's Weightless Environment Training Facility (WETF) Bldg 29. Meade is preparing for an underwater extravehicular activity (EVA) simulation. During the training exercise, Meade will rehearse contingency EVA procedures for the STS-38 mission aboard Atlantis, Orbiter Vehicle (OV) 104.

  11. Rap Music in School Counseling Based on Don Elligan's Rap Therapy

    ERIC Educational Resources Information Center

    Gonzalez, Tiphanie; Hayes, B. Grant

    2009-01-01

    In 2000, Don Elligan introduced Rap Therapy as a psychotherapeutic intervention for working with at-risk youths, primarily African American males whose identities were highly influenced by rap music. Rap music can engage a population of youth who often enter counseling apprehensively (Elligan 2000, 2004; Tillie-Allen, 2005). This article reviews…

  12. Don Hammill: A Personal Perspective on the Field of Learning Disabilities, 3-Tier, and RTI

    ERIC Educational Resources Information Center

    Intervention in School and Clinic, 2010

    2010-01-01

    Don D. Hammill received all of his formal education in Texas schools, culminating in a doctorate in educational psychology-special education from the University of Texas at Austin in 1963. He had previously served as a teacher in the Corpus Christi (Texas) public schools and as a speech and language therapist in the Deer Park (Texas) public…

  13. Dr. S. Donald (Don) Stookey (1915-2014): Pioneering Researcher and Adventurer

    NASA Astrophysics Data System (ADS)

    Beall, George H.

    2016-07-01

    Don Stookey, the father of glass-ceramics, was a pioneer in inducing and understanding internal nucleation phenomena in glass. His early work on dense opal glasses and photosensitive precipitation of gold and silver in glass led to an amazing series of inventions: Fotalite, a photosensitive opal, chemically machined Fotoform and Fotoceram, and TiO2-nucleated Pyroceram products including missile nosecones and oven-proof cookware. He received a basic patent on glass-ceramics, which was contested and affirmed in court. Don was able to demonstrate a clear photochromic glass that showed reversible darkening for thousands of cycles. This material became a fixture in the ophthalmic industry. He went on to invent a full-color polychromatic glass, capable of yielding a permanent patterned and monolithic stained glass. In his life outside science, Don chaired an interfaith group that founded a home for the elderly in Corning. He was also a wilderness enthusiast, surviving a plane crash in the Arctic and two boat capsizings. Even in his later years, he continued fishing off the coast of Florida and on Lake Ontario and went solo on a trip to the Patagonian Andes. Don Stookey was a special person by any measure: an unassuming optimist, eminent scientist and inventor, adventurer, and a beloved family man. Introduction

  14. If at First You Don't Succeed ...: A Closer Look at an Old Adage

    ERIC Educational Resources Information Center

    Baskwill, Jane

    2006-01-01

    "If at first you don't succeed, try, try again." This is a well-known adage with which many are familiar. Children learn it from an early age as they begin to walk, ride their bike, or tie their shoes. Adults repeatedly encourage children by saying, "You can do it! Give it a try! Just try harder!" However, when trying harder…

  15. STS-53 MS Clifford, in EMU, dons gloves with technicians' assistance at JSC

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-53 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) Michael R.U. Clifford, wearing extravehicular mobility unit (EMU) and communications carrier assembly (CCA), dons gloves with assistance from two technicians. Clifford is preparing for an underwater contingency extravehicular activity (EVA) simulation in JSC's Weightless Environment Training Facility (WETF) Bldg 29 pool.

  16. STS-53 MS Voss,in EMU, dons gloves with technicians' assistance at JSC's WETF

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-53 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) James S. Voss, wearing extravehicular mobility unit (EMU) and communications carrier assembly (CCA), dons his gloves with assistance from two technicians. Voss is preparing for an underwater contingency extravehicular activity (EVA) simulation in JSC's Weightless Environment Training Facility (WETF) Bldg 29 pool.

  17. 2-Year-College Students Miss out on Aid--Because Many Don't Apply

    ERIC Educational Resources Information Center

    Supiano, Beckie

    2008-01-01

    Community colleges serve a large proportion of low-income students each year, but nearly 40 percent of their full-time students don't even fill out a Free Application for Federal Student Aid. Students offer a number of reasons for not making the effort, according to a report, "Apply to Succeed: Ensuring Community College Students Benefit From…

  18. Don Hammill: A Personal Perspective on the Field of Learning Disabilities, 3-Tier, and RTI

    ERIC Educational Resources Information Center

    Intervention in School and Clinic, 2010

    2010-01-01

    Don D. Hammill received all of his formal education in Texas schools, culminating in a doctorate in educational psychology-special education from the University of Texas at Austin in 1963. He had previously served as a teacher in the Corpus Christi (Texas) public schools and as a speech and language therapist in the Deer Park (Texas) public…

  19. Don't Sweat the Big Stuff: Academic Innovation in All Shapes and Sizes

    ERIC Educational Resources Information Center

    Halfond, Jay A.

    2011-01-01

    Faculty don't give themselves enough credit for innovation and creative thinking within higher education. The soap operas of entrenched faculty, factions divided over trivia, professors protecting their sub-disciplines, lengthy and convoluted approval processes, and ongoing acrimony and melodrama all overshadow progress made without fanfare. The…

  20. STS-34 Mission Specialist (MS) Chang-Diaz dons EMU during WETF exercises

    NASA Technical Reports Server (NTRS)

    1989-01-01

    STS-34 Atlantis, Orbiter Vehicle (OV) 104, Mission Specialist (MS) Franklin R. Chang-Diaz dons extravehicular mobility unit (EMU) in preparation for an extravehicular activity (EVA) contingency exercise in JSC's Weightless Environment Training Facility (WETF) Bldg 29 pool. This closeup shows Chang-Diaz straightening his EMU sleeve.

  1. Imitate Me; Don't Imitate Me: Mimeticism in David Bartholomae's "Inventing the University."

    ERIC Educational Resources Information Center

    Boyd, Richard

    1991-01-01

    Discusses the issue of the instructor's role in the classroom with respect to David Bartholomae's "Inventing the University." Suggests an approach informed by the literary and anthropological theories of Rene Girard. Deals with Girard's views on mimetic desire. Asserts the double-bind of this view--"imitate me; don't imitate…

  2. "Don't[strikethrough] Talk with Strangers" Engaging Student Artists in Dialogic Artmaking

    ERIC Educational Resources Information Center

    Collins, Kate

    2015-01-01

    Starting with a brief description of the culminating participatory arts and dialogue event, "Don't[strikethrough] Talk With Strangers," the author then backtracks to describe the rationale and process for a new community engaged arts course centred on dialogic artmaking. The course was designed for undergraduate and youth artists with…

  3. What Catholic Educators Can Learn from the Radical Christianity and Critical Pedagogy of Don Lorenzo Milani

    ERIC Educational Resources Information Center

    Grech, Michael; Mayo, Peter

    2014-01-01

    This paper explores some of the ideas expressed in or associated with the work of Don Lorenzo Milani and the School of Barbiana and discusses them in the light of the teachings of the gospels. It draws out the implications of these ideas for a critical education in the Christian spirit. The focus throughout is on Christian education for social…

  4. Characterization and application of the enzyme peroxidase to the degradation of the mycotoxin DON.

    PubMed

    Feltrin, Ana Carla P; Garcia, Sabrina De O; Caldas, Sergiane S; Primel, Ednei G; Badiale-Furlong, Eliana; Garda-Buffon, Jaqueline

    2017-09-22

    Deoxynivalenol (DON), one of the main mycotoxins found in food matrices, has high level of toxicity. This study aimed to characterize the peroxidase enzyme extracted from rice bran to be applied to the biodegradation of DON in order to evaluate the potential peroxidase (PO) from rice bran (RB) has to degrade DON in optimal conditions. Purification and recovery factors of PO extracted from RB and purified by three-phase partitioning were 5.7% and 50%, respectively. PO had the highest level of activity in the phosphate buffer 5 mM pH 5.5 in both crude and purified forms, whose reaction temperatures were 25°C and 10°C. At the end of production, purification and characterization steps, specific activities of the bran were 115.79 U mg(-1) and 4363 U g(-1). Reduction in the mycotoxin DON in optimal conditions determined for PO from RB was 20.3%, a promising result when the aim is to adequate mycotoxicological levels to foods.

  5. [Seasonal dynamics of the abundance of vibrios and related microorganisms in the Don River].

    PubMed

    Smolikova, L M; Somova, A G; Medinskiĭ, G M; Pashentseva, N F; Orekhova, I M

    1977-12-01

    The density of bacteria of the Vibrio, Aeromonas and Comamonas genera the Don river was subject to seasonal variations. The maximal vibrio concentration was recorded at the water temperature of 22 degrees C, and of Aeromonas and Comamonas--at lower temperature. Unlike Aeromonas, vibrios displayed a reverse dependence of the density on the extent of water contamination.

  6. What We Don't Understand, We Explain to Each Other

    ERIC Educational Resources Information Center

    Pines, David

    2015-01-01

    "What we don't understand, we explain to each other" was Robert Oppenheimer's 1948 description of theoretical physics as a profession. Because the phrase connects research, teaching, and learning, it seemed the right approach for the talk I gave to the AAPT [American Association of Physics Teachers] on receiving the 2013 J.D. Jackson…

  7. STS-47 MS and PLC Lee takes a break during LES donning prior to JSC training

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-47 Endeavour, Orbiter Vehicle (OV) 105, Mission Specialist (MS) and Payload Commander (PLC) Mark C. Lee, wearing launch and entry suit, takes a break after suit donning to listen to instructions. Lee is preparing for launch emergency egress (bailout) exercises in JSC's Mockup and Integration Laboratory (MAIL) Bldg 9A.

  8. Tiffany Diamonds and Classical Music as Influences on the Performance of "Don Juan in Hell".

    ERIC Educational Resources Information Center

    Johnson, Jim

    This paper analyzes Paul Gregory's 1951 production of "Don Juan in Hell," now considered to be a seminal work in the development of professional and educational readers theatre. The paper contends that the production, which presented a nondramatic work without the usual emphasis on design and spectacle, forced a reexamination of the role…

  9. "These People Are Weird and We Don't Like Them": Reacting to Regional Difference.

    ERIC Educational Resources Information Center

    Donehower, Kim

    An instructor teaching a 20th-century fiction course was surprised by her students' response to a series of stories she asked them to read about the South. Apparently representing the feelings of many in the class, one student said, "These people are weird. And we don't like them." Though they were used to encountering differences in…

  10. Rap Music in School Counseling Based on Don Elligan's Rap Therapy

    ERIC Educational Resources Information Center

    Gonzalez, Tiphanie; Hayes, B. Grant

    2009-01-01

    In 2000, Don Elligan introduced Rap Therapy as a psychotherapeutic intervention for working with at-risk youths, primarily African American males whose identities were highly influenced by rap music. Rap music can engage a population of youth who often enter counseling apprehensively (Elligan 2000, 2004; Tillie-Allen, 2005). This article reviews…

  11. Comparison of glove donning techniques for the likelihood of gown contamination. An infection control study.

    PubMed

    Newman, James B; Bullock, Mark; Goyal, Ravi

    2007-12-01

    The creation of an optimal environment, whenever major joints are opened or metal is implanted into bone, is important to reduce infection following orthopaedic surgery. Following normal hand washing protocols, it is possible that pathogenic bacteria can remain on the skin. These bacteria may inadvertently be transferred to the surgical gown during the glove donning procedure and therefore contamination of the surgical wound could follow. We aimed to determine whether there is a difference between three differing glove donning techniques, open, closed and scrub staff assisted, in terms of accidental gown contamination, as the optimum method is unknown. Three differing glove donning techniques were assessed using ultra-violet (UV) lotion, applied to the hands after the scrub, to demonstrate patches of contamination on the surgical gowns. Two studies were carried out. An initial pilot study with theatre personnel and the main study by a single surgeon rehearsed in the various techniques. The region and size of contamination patches were documented. In the pilot study 12 out of 13 individuals were seen to have patches of UV fluorescent gown contamination following an observed scrub. In the main study, both the open and closed technique had a 100% gown contamination rate. This was concentrated around the cuff region. There were no contamination patches in the scrub staff assisted technique. Glove donning, using the scrub staff assisted technique can minimise the possibility of gown contamination. This is important in surgical procedures where the results of infection can be devastating.

  12. "Boys Don't Cry," a Movie Review: Implications for Counseling Persons Who Are Transgendered

    ERIC Educational Resources Information Center

    Aguilar, Jinnelle Veronique

    2010-01-01

    People who fall under the umbrella of transgender belong to one of the most marginalized groups within society. Many who do not pass within the gender binary categories imposed by social norms experience discrimination and marginalization. In this article, the author discusses the film "Boys Don't Cry" and introduces the reader to the varieties of…

  13. Video-Astronaut Don Pettit Discusses the Value of Space Research

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Saturday Morning Science, the science of opportunity series of applied experiments and demonstrations, performed aboard the International Space Station (ISS) by Expedition 6 astronaut Dr. Don Pettit, revealed some remarkable findings. In this video clip, Dr. Pettit speculates on the value of space research and the opportunities it offers for understanding nature's mysteries.

  14. Using "Warriors Don't Cry" in a Capstone Project to Combat Bullying

    ERIC Educational Resources Information Center

    Korneliussen, Kristin

    2012-01-01

    "Two, four, six, eight, we ain't gonna integrate!" the author's eighth-grade students shouted with gusto. They were reading "Warriors Don't Cry," Melba Patillo Beals's memoir about her experiences as one of the nine African American students who integrated Little Rock Central High School in 1957. Each time those hateful words…

  15. "Don't Know" Responding to Answerable and Unanswerable Questions during Misleading and Hypnotic Interviews

    ERIC Educational Resources Information Center

    Scoboria, Alan; Mazzoni, Giuliana; Kirsch, Irving

    2008-01-01

    "Don't know" (DK) responses to interview questions are conceptually heterogeneous, and may represent uncertainty or clear statements about the contents of memory. A study examined the subjective intent of DK responses in relation to the objective status of information queried, in the context of memory distorting procedures. Participants…

  16. Inheritance of allozyme variants in bishop pine (Pinus muricata D.Don)

    Treesearch

    Constance I. Millar

    1985-01-01

    Isozyme phenotypes are described for 45 structural loci and I modifier locus in bishop pine (Pinus muricata D. Don,) and segregation data are presented for a subset of 31 polymorphic loci from 19 enzyme systems. All polymorphic loci had alleles that segregated within single-focus Mendelian expectations, although one pair of alleles at each of three...

  17. "Don't[strikethrough] Talk with Strangers" Engaging Student Artists in Dialogic Artmaking

    ERIC Educational Resources Information Center

    Collins, Kate

    2015-01-01

    Starting with a brief description of the culminating participatory arts and dialogue event, "Don't[strikethrough] Talk With Strangers," the author then backtracks to describe the rationale and process for a new community engaged arts course centred on dialogic artmaking. The course was designed for undergraduate and youth artists with…

  18. Teaching "Don Quixote" in the Digital Age: Page and Screen, Visual and Tactile

    ERIC Educational Resources Information Center

    Boyle, Margaret; Hall, Crystal

    2016-01-01

    This current study describes an object-based learning approach to teaching "Don Quixote" as part of the curriculum for Spanish majors at a small liberal arts college. In order to maximize students' engagement with the narrative and the material culture of the novel, students worked with rare books, collaborative translation using Google…

  19. Astronaut Henry W. Harsfield, Jr. in suit donning/doffing exercise

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Astronaut Henry W. Harsfield, Jr., STS-4 pilot, takes part in a suit donning/doffing exercise aboard a KC-135 'zero-gravity' aircraft. Mission Specialist William F. Fisher, far left, stands ready to assist in the exercise. Hartsfield is wearing an extravehicular mobility unit (EMU) minus gloves and helmet.

  20. A Middle School Dilemma: Dealing with "I Don't Care"

    ERIC Educational Resources Information Center

    Walsh, Foster

    2006-01-01

    This article addresses the difficulty of engaging middle school students who don't seem to care about learning. Several classroom vignettes illustrate practical, classroom-based dilemmas generated from a university classroom management course. Three positive engagement principles are proposed to address the challenge of the reluctant learner: get…

  1. What You Don't Know Could Help You | NIH Medlineplus the Magazine

    MedlinePlus

    ... of this page please turn Javascript on. What You Don't Know Could Help You. Past Issues / Spring 2012 Table of Contents CLINICAL TRIALS — AN OPTION WORTH CONSIDERING If you're diagnosed with a medical issue, tomorrow's treatment ...

  2. "Boys Don't Cry," a Movie Review: Implications for Counseling Persons Who Are Transgendered

    ERIC Educational Resources Information Center

    Aguilar, Jinnelle Veronique

    2010-01-01

    People who fall under the umbrella of transgender belong to one of the most marginalized groups within society. Many who do not pass within the gender binary categories imposed by social norms experience discrimination and marginalization. In this article, the author discusses the film "Boys Don't Cry" and introduces the reader to the varieties of…

  3. What You Don't Know about Cancer Can Kill You

    MedlinePlus

    ... larger percentage of Americans mistakenly believe that stress, fatty diets and other unproven factors are linked with cancer, according to the institute's 2017 Cancer Risk Awareness Survey. "It's troubling that people don't recognize alcohol and processed meats increase cancer risk," Bender said ...

  4. Don't Sweat the Big Stuff: Academic Innovation in All Shapes and Sizes

    ERIC Educational Resources Information Center

    Halfond, Jay A.

    2011-01-01

    Faculty don't give themselves enough credit for innovation and creative thinking within higher education. The soap operas of entrenched faculty, factions divided over trivia, professors protecting their sub-disciplines, lengthy and convoluted approval processes, and ongoing acrimony and melodrama all overshadow progress made without fanfare. The…

  5. Don't I Wish My Professor Was Hot like Me

    ERIC Educational Resources Information Center

    Klink, William

    2010-01-01

    In this article, the author presents his reflection about the song "Don't Cha" by the Pussy Cat Dolls (2006), which makes a strong statement in a postmodern way about women, and sometimes men, who see themselves in the world as central players in a dramatic narrative that highlights their own victimization as happy, powerful, and glorious. These…

  6. Many with Advanced Lung Cancer Don't Get Treatments That Might Help

    MedlinePlus

    ... gov/news/fullstory_163162.html Many With Advanced Lung Cancer Don't Get Treatments That Might Help ... HealthDay News) -- Many U.S. patients with late-stage lung cancer do not receive treatments that could prolong ...

  7. Don't Settle: Leslie Monsalve-Jones--New Mexico State Library

    ERIC Educational Resources Information Center

    Library Journal, 2005

    2005-01-01

    Leslie Monsalve-Jones is a library technician with the New Mexico State Library, responsible for claiming documents that state agencies don't submit. She also maintains the collection and can immediately track down any requested document. In short, she is the kind of worker whose price is above rubies but whose pay is slightly above pebbles. And…

  8. "They Don't Know Anything!": Latinx Immigrant Students Appropriating the Oppressor's Voice

    ERIC Educational Resources Information Center

    Monzó, Lilia D.

    2016-01-01

    This article discusses internalized oppression among Latinx communities through a revolutionary critical pedagogy. Data from a two-year ethnography of Latinx immigrant families show that students were developing deficit perspectives toward their parents, claiming that "they don't know anything," based on their positioning as powerless…

  9. Astronaut Henry W. Harsfield, Jr. in suit donning/doffing exercise

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Astronaut Henry W. Harsfield, Jr., STS-4 pilot, takes part in a suit donning/doffing exercise aboard a KC-135 'zero-gravity' aircraft. Mission Specialist William F. Fisher, far left, stands ready to assist in the exercise. Hartsfield is wearing an extravehicular mobility unit (EMU) minus gloves and helmet.

  10. STS-47 MS and PLC Lee takes a break during LES donning prior to JSC training

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-47 Endeavour, Orbiter Vehicle (OV) 105, Mission Specialist (MS) and Payload Commander (PLC) Mark C. Lee, wearing launch and entry suit, takes a break after suit donning to listen to instructions. Lee is preparing for launch emergency egress (bailout) exercises in JSC's Mockup and Integration Laboratory (MAIL) Bldg 9A.

  11. Multiple Choice Test Bias Uncovered by Use of an "I Don't Know" Alternative.

    ERIC Educational Resources Information Center

    Sherman, Susan W.

    The multiple-choice science exercises used by the National Assessment of Educational Progress include an "I Don't Know" (IDK) alternative to estimate more accurately knowledge of groups of respondents. Group percentages of IDK responses were examined and compared with correct responses to see if the IDK introduces bias. Variance common…

  12. Teaching "Don Quixote" in the Digital Age: Page and Screen, Visual and Tactile

    ERIC Educational Resources Information Center

    Boyle, Margaret; Hall, Crystal

    2016-01-01

    This current study describes an object-based learning approach to teaching "Don Quixote" as part of the curriculum for Spanish majors at a small liberal arts college. In order to maximize students' engagement with the narrative and the material culture of the novel, students worked with rare books, collaborative translation using Google…

  13. "Don't Know" Responding to Answerable and Unanswerable Questions during Misleading and Hypnotic Interviews

    ERIC Educational Resources Information Center

    Scoboria, Alan; Mazzoni, Giuliana; Kirsch, Irving

    2008-01-01

    "Don't know" (DK) responses to interview questions are conceptually heterogeneous, and may represent uncertainty or clear statements about the contents of memory. A study examined the subjective intent of DK responses in relation to the objective status of information queried, in the context of memory distorting procedures. Participants…

  14. What We Don't Understand, We Explain to Each Other

    ERIC Educational Resources Information Center

    Pines, David

    2015-01-01

    "What we don't understand, we explain to each other" was Robert Oppenheimer's 1948 description of theoretical physics as a profession. Because the phrase connects research, teaching, and learning, it seemed the right approach for the talk I gave to the AAPT [American Association of Physics Teachers] on receiving the 2013 J.D. Jackson…

  15. "They Don't Know Anything!": Latinx Immigrant Students Appropriating the Oppressor's Voice

    ERIC Educational Resources Information Center

    Monzó, Lilia D.

    2016-01-01

    This article discusses internalized oppression among Latinx communities through a revolutionary critical pedagogy. Data from a two-year ethnography of Latinx immigrant families show that students were developing deficit perspectives toward their parents, claiming that "they don't know anything," based on their positioning as powerless…

  16. Encouraging and Clarifying "Don't Know" Responses Enhances Interview Quality

    ERIC Educational Resources Information Center

    Scoboria, Alan; Fisico, Stephanie

    2013-01-01

    Investigative interviewers seek to obtain complete and accurate accounts of events from witnesses. Two studies examined the influence of instructions about the use of don't know (DK) responses and of clarifying the meanings of DK responses on the quality of responding to questioning. Participants watched a video, and after a delay (Study 1, 30…

  17. Tiffany Diamonds and Classical Music as Influences on the Performance of "Don Juan in Hell".

    ERIC Educational Resources Information Center

    Johnson, Jim

    This paper analyzes Paul Gregory's 1951 production of "Don Juan in Hell," now considered to be a seminal work in the development of professional and educational readers theatre. The paper contends that the production, which presented a nondramatic work without the usual emphasis on design and spectacle, forced a reexamination of the role…

  18. Don't Settle: Leslie Monsalve-Jones--New Mexico State Library

    ERIC Educational Resources Information Center

    Library Journal, 2005

    2005-01-01

    Leslie Monsalve-Jones is a library technician with the New Mexico State Library, responsible for claiming documents that state agencies don't submit. She also maintains the collection and can immediately track down any requested document. In short, she is the kind of worker whose price is above rubies but whose pay is slightly above pebbles. And…

  19. Using "Warriors Don't Cry" in a Capstone Project to Combat Bullying

    ERIC Educational Resources Information Center

    Korneliussen, Kristin

    2012-01-01

    "Two, four, six, eight, we ain't gonna integrate!" the author's eighth-grade students shouted with gusto. They were reading "Warriors Don't Cry," Melba Patillo Beals's memoir about her experiences as one of the nine African American students who integrated Little Rock Central High School in 1957. Each time those hateful words…

  20. Astronauts Don Lind observes growth of crystals in VCGS aboard orbiter

    NASA Image and Video Library

    1985-04-30

    51B-01-007 (30 April 1985) --- Astronaut Don L. Lind, 51-B Spacelab 3 mission specialist, observes the growth of mercuric iodide crystal in the vapor crystal growth system (VCGS) on the Spacelab 3 science module aboard the orbiter Challenger.

  1. Don't I Wish My Professor Was Hot like Me

    ERIC Educational Resources Information Center

    Klink, William

    2010-01-01

    In this article, the author presents his reflection about the song "Don't Cha" by the Pussy Cat Dolls (2006), which makes a strong statement in a postmodern way about women, and sometimes men, who see themselves in the world as central players in a dramatic narrative that highlights their own victimization as happy, powerful, and glorious. These…

  2. 33 CFR 208.82 - Hetch Hetchy, Cherry Valley, and Don Pedro Dams and Reservoirs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Hetch Hetchy, Cherry Valley, and..., Cherry Valley, and Don Pedro Dams and Reservoirs. The Turlock Irrigation District and Modesto Irrigation..., shall operate Hetch Hetchy Dam and Reservoir and Cherry Valley Dam and Reservoir in the interest of...

  3. 33 CFR 208.82 - Hetch Hetchy, Cherry Valley, and Don Pedro Dams and Reservoirs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Hetch Hetchy, Cherry Valley, and..., Cherry Valley, and Don Pedro Dams and Reservoirs. The Turlock Irrigation District and Modesto Irrigation..., shall operate Hetch Hetchy Dam and Reservoir and Cherry Valley Dam and Reservoir in the interest of...

  4. 33 CFR 208.82 - Hetch Hetchy, Cherry Valley, and Don Pedro Dams and Reservoirs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Hetch Hetchy, Cherry Valley, and..., Cherry Valley, and Don Pedro Dams and Reservoirs. The Turlock Irrigation District and Modesto Irrigation..., shall operate Hetch Hetchy Dam and Reservoir and Cherry Valley Dam and Reservoir in the interest of...

  5. 33 CFR 208.82 - Hetch Hetchy, Cherry Valley, and Don Pedro Dams and Reservoirs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Hetch Hetchy, Cherry Valley, and..., Cherry Valley, and Don Pedro Dams and Reservoirs. The Turlock Irrigation District and Modesto Irrigation..., shall operate Hetch Hetchy Dam and Reservoir and Cherry Valley Dam and Reservoir in the interest of...

  6. 33 CFR 208.82 - Hetch Hetchy, Cherry Valley, and Don Pedro Dams and Reservoirs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Hetch Hetchy, Cherry Valley, and..., Cherry Valley, and Don Pedro Dams and Reservoirs. The Turlock Irrigation District and Modesto Irrigation..., shall operate Hetch Hetchy Dam and Reservoir and Cherry Valley Dam and Reservoir in the interest of...

  7. The Don Bosco Way to Train Disadvantaged Youth. Discussion Paper No. 92.

    ERIC Educational Resources Information Center

    Mashek, R. W.

    Founded by Don Bosco in 1859 in Turin, Italy, the Salesian Society helps disadvantaged youth in over 100 countries, according to 1991 data. Salesians operate technical training institutes and run numerous informal shops and training courses within their schools, orphanages, street children shelters, and youth centers. The institutes are financed…

  8. STS-28 Columbia, OV-102, MS Brown dons LES in JSC Mockup and Integration Lab

    NASA Technical Reports Server (NTRS)

    1989-01-01

    STS-28 Columbia, Orbiter Vehicle (OV) 102, Mission Specialist (MS) Mark N. Brown, wearing communications carrier assembly (CCA) and launch and entry suit (LES), prepares to don launch and entry helmet (LEH). Brown suits up for shuttle emergency egress (bailout) procedures in JSC Mockup and Integration Laboratory Bldg 9A.

  9. Dissolved organic nitrogen (DON) during batch denitrification of low concentrations of nitrate using suspended and attached biomass.

    PubMed

    Brandão, D N; Spanjers, H; van Lier, J B

    2015-01-01

    The occurrence and removal of dissolved organic nitrogen (DON) is an issue of increasing importance for the reclamation of treated wastewater. Effluent DON may act as a precursor of disinfection by-products during wastewater disinfection and may contribute to eutrophication of receiving surface waters. The aim of this study was to understand the effect of the post-denitrification process on final effluent DON (organic nitrogen filtered by 0.45 μm pore size) concentration to further gain knowledge on how to optimize denitrifying filtration, in order to reach the required discharge standards. To evaluate DON variation, denitrification batch experiments were carried out with suspended and attached biomass under different shear conditions. For both conditions, with suspended and attached biomass, DON concentration did not increase or decrease during the denitrification process with addition of an external carbon source. Moreover, the increase of shear rate did not affect the DON concentration. Apparently, there is no direct link between DON evolution and the denitrification process itself.

  10. Decoupling of DOC and DON at the watershed scale - what can it tell us about DOM and watershed function? (Invited)

    NASA Astrophysics Data System (ADS)

    McDowell, W. H.; Daley, M. L.; Aitkenhead-Peterson, J. A.

    2009-12-01

    The past decade has seen an explosion of interest in DOM, with considerable interest in the biogeochemical behavior and ecological function of both DOC and DON. Controls on DOC flux from watersheds have been examined in numerous studies, but much less is know about watershed-scale control on DON flux. Although DOC and DON are only different fractions of the same DOM pool, they can at times behave differently, and in that sense they are “decoupled.” In the suburban Lamprey River watershed in New Hampshire, for example, DOC concentrations do not show relationships with stream discharge, but DON concentrations do show a statistically significant relationship. Other previously published studies have noted the same decoupling of DOC and DON during storms. In the tropical Luquillo Mountains of Puerto Rico, streamwater DOC/DON ranges from 12 to 25 among watersheds located within 10 kilometers of each other. Despite evident similarities in the vegetation, rainfall, and geology of these watersheds, large differences exist in the relative abundance of the carbon- and nitrogen-rich fraction of DOM generated in each watershed. Drivers for decoupling during storms could include differences in DOM sources during storms (e.g. more throughfall), or differential transport of DOC and DON due to differential sorption of each along high-flow and low-flow pathways. Potential drivers for spatial variability in stream DOC/DON ratio among watersheds include differences in soil C and N content or flow paths among watersheds. Evidence for the importance of these mechanisms, and a conceptual model for drivers of DOC/DON decoupling, will be presented.

  11. Impact of three biological decontamination methods on filtering facepiece respirator fit, odor, comfort, and donning ease.

    PubMed

    Viscusi, Dennis J; Bergman, Michael S; Novak, Debra A; Faulkner, Kimberly A; Palmiero, Andrew; Powell, Jeffrey; Shaffer, Ronald E

    2011-07-01

    The objective of this study was to determine if ultraviolet germicidal irradiation (UVGI), moist heat incubation (MHI), or microwave-generated steam (MGS) decontamination affects the fitting characteristics, odor, comfort, or donning ease of six N95 filtering facepiece respirator (FFR) models. For each model, 10 experienced test subjects qualified for the study by passing a standard OSHA quantitative fit test. Once qualified, each subject performed a series of fit tests to assess respirator fit and completed surveys to evaluate odor, comfort, and donning ease with FFRs that were not decontaminated (controls) and with FFRs of the same model that had been decontaminated. Respirator fit was quantitatively measured using a multidonning protocol with the TSI PORTACOUNT Plus and the N95 Companion accessory (designed to count only particles resulting from face to face-seal leakage). Participants' subjective appraisals of the respirator's odor, comfort, and donning ease were captured using a visual analog scale survey. Wilcoxon signed rank tests compared median values for fit, odor, comfort, and donning ease for each FFR and decontamination method against their respective controls for a given model. Two of the six FFRs demonstrated a statistically significant reduction (p < 0.05) in fit after MHI decontamination. However, for these two FFR models, post-decontamination mean fit factors were still ≥ 100. One of the other FFRs demonstrated a relatively small though statistically significant increase (p < 0.05) in median odor response after MHI decontamination. These data suggest that FFR users with characteristics similar to those in this study population would be unlikely to experience a clinically meaningful reduction in fit, increase in odor, increase in discomfort, or increased difficulty in donning with the six FFRs included in this study after UVGI, MHI, or MGS decontamination. Further research is needed before decontamination of N95 FFRs for purposes of reuse can be

  12. When drugs and surgery don't work.

    PubMed

    Cascino, Gregory D

    2008-12-01

    Epilepsy is a chronic disorder characterized by recurrent and unprovoked seizures (Dreifuss, 1987; Hauser & Hesdorffer, 1990). It is one of the most common neurologic disorders in the adult. The lifetime risk of developing epilepsy is 3.2% (Mattson, 1992). Approximately 90% of the incident cases in adults have symptomatic partial or localization-related epilepsy (Camfield & Camfield, 1996; Hauser & Hesdorffer, 1990; Hauser, 1992). The medial temporal lobe is the most epileptogenic region of the brain (Luby et al., 1995; Jeong et al., 1999; Wiebe et al., 2001). Pathologic lesions underlying the epileptogenic zone include mesial temporal sclerosis (MTS), tumor, vascular anomaly, malformations of cortical development (MCDs), and head trauma (Cascino et al., 1993; Radhakrishnan et al., 1998). The initial response to medication is of prognostic importance (Hauser, 1992). Patients with a remote symptomatic neurologic disease, foreign-tissue lesion, developmental delay, or abnormal neurologic examination are less likely to be rendered seizure-free. The goals of treatment are to render the individual seizure-free without producing antiepileptic drug (AED) toxicity, allowing the individual to become a participating and productive member of society (Engel & Ojemann, 1993). Despite the introduction of "newer" AEDs, nearly one-half of patients with partial epilepsy will not attain a seizure remission with pharmacotherapy (Kwan & Brodie, 2003). This discussion focuses on management of the adult patient with intractable partial seizure disorders that are medically refractory and may not be surgically remediable. It is estimated that 400,000 of the 2 million individuals with partial epilepsy in the United States have a medically refractory partial seizure disorder (Hauser & Hesdorffer, 1990; Hauser, 1992). An estimated 1,500 patients in the United States undergo epilepsy surgery each year. A UK study indicated that 30,000 patients develop epilepsy each year and approximately 6

  13. Abu al-Layth al-Libi

    DTIC Science & Technology

    2015-02-01

    jihadi doctrine, al-Libi enrolled himself in the recently erected and highly popular al-Faruq 2 “Al-Sahab Releases ‘Winds of Paradise , Part III...February 2008, http://news.bbc.co.uk/2/hi/south_asia/7220823.stm. 3 “Al-Sahab Releases ‘Winds of Paradise , Part III,’” Global Terrorism Research Project...5 “Al-Sahab Releases ‘Winds of Paradise , Part III,’” Global Terrorism Research Project. 6 Ibid. The date provided in the video is 1410

  14. What Is ALS?

    MedlinePlus

    ... Javits, actor David Niven, “Sesame Street” creator Jon Stone, boxing champion Ezzard Charles, NBA Hall of Fame ... Help for People with ALS and Caregivers Read stories from families living with ALS Forms of ALS ...

  15. 43 CFR 4300.55 - What if I don't agree with an adjustment of my permit area?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR RANGE MANAGEMENT (4000) GRAZING ADMINISTRATION; ALASKA; REINDEER; GENERAL Changes in the Size of the Permit Area § 4300.55 What if I don't agree...

  16. 43 CFR 4300.55 - What if I don't agree with an adjustment of my permit area?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR RANGE MANAGEMENT (4000) GRAZING ADMINISTRATION; ALASKA; REINDEER; GENERAL Changes in the Size of the Permit Area § 4300.55 What if I don't agree...

  17. University Mentality or Community College Paranoia: A Critique of Don Morgan's Reaction to David Riesman's Tentative Hypotheses.

    ERIC Educational Resources Information Center

    Vaughan, George B.

    1979-01-01

    Responds to Don Morgan's reaction (JC 502 050) to David Riesman's article, "Community Colleges: Some Tentative Hypotheses" (JC 502 056). Summarizes Riesman's major arguments and challenges Morgan's interpretations of them. (AYC)

  18. Honey buzzards don't always make a beeline.

    PubMed

    Chapman, Jason W

    2017-03-01

    (a) European honey buzzards breeding in Western Europe primarily use soaring flight to make annual long-range migrations via the Strait of Gibraltar to winter in West Africa; this adult male was photographed on migration near Gibraltar. Photo: Javier Elloriaga. (b) Autumn migration routes of 12 satellite tagged adult European honey buzzards (colour-coded lines); compared with the shortest possible straight-line routes (dashed lines), most routes involved substantial westerly detours in Africa. Adapted from Vansteelant et al. (2016). (c) In contrast, Montagu's harriers predominantly use flapping flight during their migrations; this adult male is carrying a satellite transmitter. Photo: Theo van Kooten. (d) Autumn migration routes of 34 satellite tagged adult Montagu's harriers; migratory tracks more closely approached straight-line routes, and typically involved longer sea crossings, than seen in European honey buzzards. Adapted from Trierweiler et al. (). In Focus: Vansteelant, W.M.G., Shamoun-Baranes, J., van Manen, W., van Diermen, J. & Bouten, W. (2017) Seasonal detours by soaring migrants shaped by wind regimes along the East Atlantic Flyway. Journal of Animal Ecology, 86, 179-191. Migratory birds often make substantial detours from the shortest possible route during their annual migrations, which may potentially increase the duration and energetic cost of their journeys. Vansteelant et al. () investigate repeated migrations of adult European honey buzzards between the Netherlands and sub-Saharan Africa, and find that they make large westerly detours in Africa on both the spring and autumn routes. These detours allow migrants to capitalise on more favourable winds further along the route, thus reducing energy expenditure. Lifelong tracking studies will allow researchers to identify how migration routes have evolved to exploit predictable atmospheric and oceanic circulation patterns. © 2017 The Author. Journal of Animal Ecology © 2017 British Ecological

  19. Colloidal Iron, Aluminum, and DOC/DON in Surface Waters of the Northwest Pacific: Results from the 2002 NSF/IOC Cruise

    NASA Astrophysics Data System (ADS)

    Sonke, J.; Landing, W. M.

    2002-12-01

    Over 70 surface seawater samples were collected on the 2002 NSF/IOC cruise between Japan and Hawaii using a towed "fish" peristaltic pump trace-metals clean sampling system. Samples for total dissolved Fe and AL were filtered using 0.2 um cartridge filters. Colloidal Fe and Al were isolated using a Millipore PrepScale 1 kDa regenerated cellulose tangential flow ultrafiltration device. Concentration factors were 8-10. Aluminum concentrations were measured using the lumogallion fluorometric technique; Fe concentrations were measured by Fe-57 isotope dilution with a Finnegan Element high-resolution magnetic sector ICPMS. Total dissolved Fe concentrations ranged from 0.2 to 0.6 nM and were weakly correlated with atmospheric Fe deposition (calculated from aerosol Fe concentrations). Colloidal Fe ranged from 10-60 percent of the total dissolved Fe and appeared to be related to atmospheric input and biological activity. We will discuss the relationships between the concentrations of particulate, dissolved and colloidal Fe, Al, and DOC/DON and the intertwined effects of atmospheric input, complexation by natural ligands, and physical dilution into the mixed layer.

  20. An Analysis of Opinion of the Impact of Don’t Ask Don’t Tell, Its Repeal, and the Proposed Plan to Implement the Repeal

    DTIC Science & Technology

    2011-06-05

    Ask Don’t Tell, Its Repeal, N/A and the Proposed Plan to lmple.ment the Repeal 5b. GRANT NUMBER N/A 5c. PROGRAM ELEMENT NUMBER N/A "’ 6. AUTHOR{ S ...5d. PROJECT NUMBER Major Darrel Choat, USMC N/A 5e. TASK NUMBER < N/A 5f. WORK UNIT NUMBER N/A 7. PERFORMING ORGANIZATION NAME{ S ) AND ADDRESS...9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM{ S ) N/A N/A 11. SPONSORING/MONITORING AGENCY REPORT NUMBER 1

  1. Mujeres que Consumen Sustancias y su Vulnerabilidad frente al VIH en Santiago de Chile (Women Who Consume Substances and Their Vulnerability to HIV in Santiago of Chile).

    PubMed

    Irarrázabal, Lisette P; Ferrer, Lilian; Villegas, Natalia; Sanhueza, Sebastián; Molina, Yerko; Cianelli, Rosina

    2016-06-01

    Women represent 15% of the people living with HIV in Chile. Risk behaviors for HIV are: multiple partners, unsafe sex, and exchange of sex for drugs/money. A correlational design was used. A sample of 203 women who were sexually active and consumed substances within the last 3-months were selected for this study. The average age of the participants was 32.4 years (SD = 9.2) and 68.1% were housewives. The substance most commonly used was alcohol (95.1%) and marijuana (49.8%); 23.7% of the women were drunk or drugged before having sex; 74.4% had multiple sexual partners and 95.6% had unprotected sex. There is a significant correlation (p < 0.05) between substance abuse and HIV risk behaviors. It is necessary to develop more research to understand in depth the relationship between substance use and HIV risk among Chilean women. It is important to consider the use of substances to develop and implement HIV prevention programs in the Chilean community. © The Author(s) 2016.

  2. 25 CFR 171.545 - What can happen if I don't pay my bill on time?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What can happen if I don't pay my bill on time? 171.545... if I don't pay my bill on time? (a) We will not provide you irrigation service until: (1) Your bill... 90th day after the due date, we will assess you a penalty, as required by 31 CFR 901.9(d). Penalties...

  3. 25 CFR 171.545 - What can happen if I don't pay my bill on time?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What can happen if I don't pay my bill on time? 171.545 Section 171.545 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION... if I don't pay my bill on time? (a) We will not provide you irrigation service until: (1) Your bill...

  4. 25 CFR 171.545 - What can happen if I don't pay my bill on time?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What can happen if I don't pay my bill on time? 171.545 Section 171.545 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION... if I don't pay my bill on time? (a) We will not provide you irrigation service until: (1) Your bill...

  5. 25 CFR 171.545 - What can happen if I don't pay my bill on time?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What can happen if I don't pay my bill on time? 171.545 Section 171.545 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION... if I don't pay my bill on time? (a) We will not provide you irrigation service until: (1) Your bill...

  6. 25 CFR 171.545 - What can happen if I don't pay my bill on time?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What can happen if I don't pay my bill on time? 171.545 Section 171.545 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION... if I don't pay my bill on time? (a) We will not provide you irrigation service until: (1) Your bill...

  7. Mindless processing of requests? Don't ask twice.

    PubMed

    Slugoski, B R

    1995-09-01

    This study examines the mindlessness hypothesis and its associated compliance-gaining paradigm from the perspective of politeness theory. The main prediction of politeness theory, which is not taken into account in the mindlessness literature, is that the perceived magnitude of an imposition is a function not only of the size of favour asked but also of the framing of the request itself. A confederate asked students studying in the library for either one or 10 sheets of paper using appropriate variations of Langer et al.'s three request types: no reason, placebic reason and real reason. Students then completed a questionnaire to determine: (a) how large the imposition on them had been; (b) their verbatim memories for the requests; and (c) self-reported compliance with the requests. In order to examine the effect of reflective thought on subjects' judgements and recall, this questionnaire was completed either immediately following compliance/non-compliance or three minutes later. The analyses established that the perceived imposition is influenced jointly by the actual imposition, the type of request and the time of judgement. Further, contrary to some previous research, the recall memory data provide support for a strong version of the mindlessness hypothesis, as well as new evidence for the reconstructive character of conversation memory. It is concluded that politeness theory describes a powerful heuristic that people use when processing requests.

  8. Deoxynivalenol (DON) Contamination of Feed and Grinding Fineness: Are There Interactive Implications on Stomach Integrity and Health of Piglets?

    PubMed Central

    Dänicke, Sven; Beineke, Andreas; Berk, Andreas; Kersten, Susanne

    2017-01-01

    The common feed contaminant deoxynivalenol (DON) was reported to influence the morphology of the pars nonglandularis (PN) of porcine stomach. Moreover, finely ground feed is known to trigger the development of ulcers and other pathologies of PN while coarsely ground feed protects from such lesions. The interactions between grinding fineness and DON contamination of feed were not examined so far. Therefore, both finely and coarsely ground feeds were tested either in the absence or presence of a DON contaminated wheat on growth performance and health of rearing piglets, including stomach integrity. DON contamination significantly reduced feed intake and serum albumin concentration with this effect being more pronounced after feeding the coarsely ground feed. Albeit at a higher level, albumin concentration was also reduced after feeding the finely ground and uncontaminated feed. Finely ground and DON-contaminated feed caused a significantly more pronounced lymphoplasmacytic infiltration both of PN and pars glandularis, partly paralleled by lymph follicle formation and detritus filled foveolae and tubes suggesting a local immune response probably triggered by epithelial lesions. It is concluded that DON contamination of feed exacerbates the adverse effects of finely ground feed on stomach mucosal integrity. PMID:28045426

  9. A novel recombinant cell fluorescence biosensor based on toxicity of pathway for rapid and simple evaluation of DON and ZEN

    PubMed Central

    Ji, Jian; Gu, Wenshu; Sun, Chao; Sun, Jiadi; Jiang, Hui; Zhang, Yinzhi; Sun, Xiulan

    2016-01-01

    During an exposure, humans and animals are most often exposed to a mixture rather than individual mycotoxins. In this study, a Human Embryonic Kidney 293 cell (HEK-293) fluorescence sensor was developed to detect and evaluate mycotoxins, deoxynivalenol (DON) and zearalenone (ZEN) compounds, produced by Fusarium culmorum that are common food contaminants. TRE-copGFP (green fluorescent protein) and ERE-TagRFP (red fluorescent protein) plasmids were constructed and cotransfected into HEK-293 cells through a highly efficient, lipid-mediated, DNA-transfection procedure. Results show that fluorescence intensity was proportional to DON and ZEN concentrations, ranging from 2 to 40 ng/mL and 10 to 100 ng/mL respectively, with a detection limit of 0.75 ng/mL and 3.2 ng/mL respectively. The EC50 of DON and ZEN are 30.13 ng/mL and 76.63 ng/mL respectively. Additionally, ZEN may have a synergistic effect on enhancing AP-1 activity of the toxicity pathway of DON. These data indicate the high sensitivity and effectiveness of our biosensor system in the evaluation of the combined toxicity of ZEN, DON and their derivatives. In addition, this approach is suitable for an early warning method for the detection of ZEN and DON family mycotoxins contamination without higher-priced, conventional analytical chemistry methods. PMID:27498557

  10. Deoxynivalenol (DON) Contamination of Feed and Grinding Fineness: Are There Interactive Implications on Stomach Integrity and Health of Piglets?

    PubMed

    Dänicke, Sven; Beineke, Andreas; Berk, Andreas; Kersten, Susanne

    2017-01-01

    The common feed contaminant deoxynivalenol (DON) was reported to influence the morphology of the pars nonglandularis (PN) of porcine stomach. Moreover, finely ground feed is known to trigger the development of ulcers and other pathologies of PN while coarsely ground feed protects from such lesions. The interactions between grinding fineness and DON contamination of feed were not examined so far. Therefore, both finely and coarsely ground feeds were tested either in the absence or presence of a DON contaminated wheat on growth performance and health of rearing piglets, including stomach integrity. DON contamination significantly reduced feed intake and serum albumin concentration with this effect being more pronounced after feeding the coarsely ground feed. Albeit at a higher level, albumin concentration was also reduced after feeding the finely ground and uncontaminated feed. Finely ground and DON-contaminated feed caused a significantly more pronounced lymphoplasmacytic infiltration both of PN and pars glandularis, partly paralleled by lymph follicle formation and detritus filled foveolae and tubes suggesting a local immune response probably triggered by epithelial lesions. It is concluded that DON contamination of feed exacerbates the adverse effects of finely ground feed on stomach mucosal integrity.

  11. Thermal stability improvements to the ESPaDOnS spectrograph with the addition of a thermal enclosure

    NASA Astrophysics Data System (ADS)

    Barrick, Gregory; Benedict, Tom; Moutou, Claire; Malo, Lison; White, John; Chene, André-Nicolas; Lundquist, Michael

    2016-08-01

    As part of GRACES (Gemini Remote Access to CFHT ESPaDOnS Spectrograph), a project to link the Gemini-North telescope to the ESPaDOnS (Echelle Polarimetric Device for the Observation of Stars) spectrograph at CFHT (Canada- France-Hawaii Telescope), the original thermal enclosure of the spectrograph needed to be modified. Although the modifications were slight, there was a significant possibility that the thermal stability of ESPaDOnS would be somewhat compromised. To eliminate this risk, a walk-in thermal enclosure was purchased and installed around the ESPaDOnS spectrograph as part of the GRACES project. The thermal impact of these modifications to the ESPaDOnS environment will be analyzed and the effect of the changes on the amplitude and behavior of the spectral drift for the ESPaDOnS and GRACES instruments will be examined. While the outer enclosure has reduced the extremes in thermal variation, this has not had a direct effect on the stability of the spectra.

  12. Phytic acid protects porcine intestinal epithelial cells from deoxynivalenol (DON) cytotoxicity.

    PubMed

    Pacheco, Graziela Drociunas; Silva, Caio Abércio da; Pinton, Philippe; Oswald, Isabelle P; Bracarense, Ana Paula Frederico Rodrigues Loureiro

    2012-05-01

    The purpose of this study was to evaluate the effects of phytic acid (IP(6)) as a possible inhibitor of cellular damage induced by toxic substances such as mycotoxins on a porcine intestinal epithelial cell line (IPEC-1). We first observed that a dose of 5 mM phytic acid decreases cell viability and transepithelial electrical resistance (TEER) of cell monolayer. We next investigate the effect of non-cytotoxic dose of phytic acid on the deoxinivalenol (DON) induced decreased TEER. We showed that treatment with 0.5 mM or 1.0 mM phytic acid restores the decrease in TEER caused by 25 μM DON. In conclusion this study demonstrates that phytic acid decreased the negative effects of deoxynivalenol on the membrane integrity of the IPEC-1 intestinal epithelial cell line.

  13. ["Is it an animal inside? "Melanie Klein's unpublished Don Juan Paper (1939)].

    PubMed

    Frank, Claudia

    2008-01-01

    Klein had been asked to contribute an article to the birthday number of the International Journal for Jones. The author outlines how she hurriedly wrote a text about Don Juan which, however, was rejected by the editor. Essential parts of it are presented in German translation. The manuscript is discussed in the context of Klein's published work as well as of the relevant contemporary literature. In Klein's view, Don Juan's genitality is determined by oral impulses and fears. By his manic acting out he attempts to ward off a depressive break-down. The paper ends with some reflections about why Klein--ontrary to her intention--failed to revise her manuscript for later publication.

  14. Abiotic nitrous oxide emission from the hypersaline Don Juan Pond in Antarctica

    NASA Astrophysics Data System (ADS)

    Samarkin, Vladimir A.; Madigan, Michael T.; Bowles, Marshall W.; Casciotti, Karen L.; Priscu, John C.; McKay, Christopher P.; Joye, Samantha B.

    2010-05-01

    Nitrous oxide is a potent atmospheric greenhouse gas that contributes to ozone destruction. Biological processes such as nitrification and denitrification are thought to drive nitrous oxide production in soils, which comprise the largest source of nitrous oxide to the atmosphere. Here we present measurements of the concentration and isotopic composition of nitrous oxide in soil pore spaces in samples taken near Don Juan Pond, a metabolically dormant hypersaline pond in Southern Victoria Land, Antarctica in 2006, 2007 and 2008, together with in situ fluxes of nitrous oxide from the soil to the atmosphere. We find fluxes of nitrous oxide that rival those measured in fertilized tropical soils. Laboratory experiments-in which nitrite-rich brine was reacted with a variety of minerals containing Fe(II)-reveal a new mechanism of abiotic water-rock reaction that could support nitrous oxide fluxes at Don Juan Pond. Our findings illustrate a dynamic and unexpected link between the geosphere and atmosphere.

  15. Correcting polarization crosstalk in the ESPaDOnS spectro-polarimeter

    NASA Astrophysics Data System (ADS)

    Barrick, Gregory; Benedict, Tom; Sabin, Dan

    2010-07-01

    ESPaDOnS is a high-resolution, cross-dispersed, fiber fed, echelle spectrograph in use at the Canada-France-Hawaii Telescope (CFHT). The light from the telescope passes through a polarimeter stage before being injected into the fibers that feed the spectrograph, so the instrument is capable of determining the polarization of the stellar spectra from 370 - 1000 nm in wavelength. One limit to the accuracy of the polarimetry is the inevitable polarization crosstalk added by all optics prior to polarization analysis. The main source of this crosstalk is stress birefringence in the glass of the optics; either residual from the annealing process or induced by the mounting of the optics. The process by which the crosstalk in ESPaDOnS has been reduced from 5% or more to less than 1% is discussed in this paper.

  16. Five things they don't teach you in medical school.

    PubMed

    Ball, Chad G; Grondin, Sean C; Dixon, Elijah; Lillemoe, Keith D; Bhandari, Mohit; Parry, Neil

    2016-09-01

    You graduate from medical school with dreams of beginning your residency, during which you will study and train within the specialty you love more than any other. While you may be book-smart at this point in your career, medical school does not teach you everything you need to know. During residency you will learn the didactic and technical requirements for your future staff job, but medical school won't explicitly address many of the crucial "dos and don'ts" of a successful 2- to 5-year postgraduate training voyage. Here we discuss a few of the important things about residency that you'll need to know that they don't teach you in medical school.

  17. Ozonation of whole wheat flour and wet milling effluent: Degradation of deoxynivalenol (DON) and rheological properties.

    PubMed

    Alexandre, Allana P S; Castanha, Nanci; Calori-Domingues, Maria A; Augusto, Pedro E D

    2017-07-03

    The objective of this study was to evaluate the reduction on the levels of the mycotoxin deoxynivalenol (DON) in whole wheat flour (WWF) with different moisture levels, on the wet milling effluent through ozone (O3) processing, as well as the impact of ozonation on the rheological properties of flour. The results have shown that the reduction of DON was improved with increasing moisture and exposure time of WWF and wet milling effluent to ozone. The maximum reduction was about 80%, proving that ozonation is an effective and promising technology in reducing mycotoxins in different products. However, the process altered the rheological profile of WWF. Therefore, further studies are needed to better understand the process.

  18. Astronaut Curtis L. Brown, Jr., pilot, gets helped with the final touches of suit donning during

    NASA Technical Reports Server (NTRS)

    1996-01-01

    STS-77 TRAINING VIEW --- Astronaut Curtis L. Brown, Jr., pilot, gets helped with the final touches of suit donning during emergency bailout training for crew members in the Johnson Space Centers (JSC) Weightless Environment Training Facility (WET-F). Astronaut John H. Casper (in background), mission commander, awaits the actual training to begin. Brown and Casper will join four other astronauts for nine days aboard the Space Shuttle Endeavour next month.

  19. Video- Astronauts Don Pettit and Ken Bowersox Paint Water Onboard the International Space Station

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Saturday Morning Science, the science of opportunity series of applied experiments and demonstrations, performed aboard the International Space Station (ISS) by Expedition 6 astronaut Dr. Don Pettit, revealed some remarkable findings. Science begets art in this video as Dr. Pettit and commander Ken Bowersox demonstrate two dimensional diffusion using food coloring in a film of water when they created an intriguing birdlike image. Dr. Pettit wonders aloud 'It makes us wonder what Matisse could do with a medium like this.'

  20. Heavy Metals and Biogenic Elements in Aquatic Systems of the Don River Delta

    NASA Astrophysics Data System (ADS)

    Tkachenko, Anna; Tkachenko, Oleg

    2014-05-01

    River deltas are located in the lower parts of the cascade landscape-geochemical systems of the river basins, so their geochemical conditions often characterize the anthropogenic impact on whole river system. The Don River runs through the one of the most agriculturally developed and densely populated area of Russia, and flows into the Azov Sea - the smallest and shallowest sea in the world. These factors determine the geochemical features of aquatic systems of the Don River mouth area and the specificity of the "river-sea" geochemical barrier zone. The paper presents results of the field studies of the geochemical structure of the Don River mouth area, which were conducted in frames of the RFBR project in 2012-2013. Major types of the deltaic water streams and bodies were studied in different hydrological seasons: spring floods, summer, autumn and winter low water periods. About 50 samples of water, suspended matter and 60 samples of bottom sediments have been collected and analyzed for heavy metals (Fe, Mn, Zn, Cu, Ni, Co, Pb, Cr, Cd etc.) and biogenic elements (nitrate, nitrite, ammonium, phosphates, silica, total nitrogen and phosphorus, dissolved oxygen and chlorophyll) content. To assess the toxicity degree and nutrient potential of water, bioassay test conducted by growing daphnia in water samples were held. The study shows that the Don River delta water is characterized by the relatively low values of dissolved heavy metal content. Significantly higher values of heavy metals were determined in the vicinity of settlements only. Metal accumulation in bottom sediments can be associated mainly with the rate of water flow. Higher values were found in sediments of small channels with weak flow velocity and prevailing processes of the suspended matter deposition. The data on the seasonal dynamics of nutrients and spatial variability of their forms have been obtained. The maximum concentration of nitrogen, phosphorus, silicon, and other biogenic elements are

  1. The Negative Behaviors of Coaches: "Don't Be This Guy!"

    ERIC Educational Resources Information Center

    Stewart, Craig

    2013-01-01

    Introduction: Kickoff is 11:00 am and all the players are on the pitch being warmed up by a parent--all the players except one, of course, and her father, the coach. Sure, it is only an under-8 recreational match, but don't all players deserve a responsible coach? When he finally wanders in from the parking lot, he is in his cutoffs and flip…

  2. STS-38 Mission Specialist (MS) Robert C. Springer dons EMU in JSC's WETF

    NASA Technical Reports Server (NTRS)

    1990-01-01

    STS-38 Mission Specialist (MS) Robert C. Springer dons extravehicular mobility unit (EMU) upper torso with technicians' assistance in JSC's Weightless Environment Training Facility (WETF) Bldg 29. Positioned on the WETF platform at pool side, Springer is preparing for an underwater extravehicular activity (EVA) simulation. During the training session, Springer will rehearse contingency EVA procedures for the STS-38 mission aboard Atlantis, Orbiter Vehicle (OV) 104.

  3. STS-38 Mission Specialist (MS) Robert C. Springer dons EMU in JSC's WETF

    NASA Technical Reports Server (NTRS)

    1990-01-01

    STS-38 Mission Specialist (MS) Robert C. Springer, wearing extravehicular mobility unit (EMU), fastens the strap on his communications carrier assembly (CCA) cap during suit donning in JSC's Weightless Environment Training Facility (WETF) Bldg 29. Positioned on the WETF platform at pool side, Springer is preparing for an underwater extravehicular activity (EVA) simulation. During the training exercise, Springer will rehearse contingency EVA procedures for the STS-38 mission aboard Atlantis, Orbiter Vehicle (OV) 104.

  4. Enterovirus A71 Meningoencephalitis Outbreak, Rostov-on-Don, Russia, 2013.

    PubMed

    Akhmadishina, Ludmila V; Govorukhina, Marina V; Kovalev, Evgeniy V; Nenadskaya, Svetlana A; Ivanova, Olga E; Lukashev, Alexander N

    2015-08-01

    Seventy-eight cases of enterovirus infection, including 25 neuroinfections, occurred in Rostov-on-Don, Russia, during May-June 2013. The outbreak was caused by an enterovirus A type 71 (EV-A71) subgenotype C4 lineage that spread to neighboring countries from China ≈3 years earlier. Enterovirus associated neuroinfection may emerge in areas with a preceding background circulation of EV-A71 with apparently asymptomatic infection.

  5. STS-39 MS Bluford dons EMU lower torso in preparation for dive in JSC's WETF

    NASA Technical Reports Server (NTRS)

    1990-01-01

    STS-39 Mission Specialist (MS) Guion S. Bluford, wearing liquid cooling and ventilation garment (LCVG), has just donned the extravehicular mobility unit (EMU) lower torso in preparation for an underwater simulation in JSC's Weightless Environment Training Facility (WETF) Bldg 29. When fully suited in his EMU, Bluford will be lowered into the water by a hoist device for the underwater rehearsal of contingency extravehicular activity (EVA) procedures.

  6. Reflections on Don Juan and on the utility of the unhappy love affair.

    PubMed

    Bergel, Ernest

    2011-12-01

    Based on an unusual clinical experience of a teenage boy in child psychotherapy, two conclusions are proposed: (1) that the extremely unhappy, early love affairs that occur in most men's lives serve a valuable function in helping them separate from their mothers sufficiently to be able to realistically relate to appropriate marriage partners, and (2) that some Don Juans start new relationships in order to break them off, rather than the reverse.

  7. Astronaut Curtis L. Brown, Jr., pilot, gets helped with the final touches of suit donning during

    NASA Technical Reports Server (NTRS)

    1996-01-01

    STS-77 TRAINING VIEW --- Astronaut Curtis L. Brown, Jr., pilot, gets helped with the final touches of suit donning during emergency bailout training for crew members in the Johnson Space Centers (JSC) Weightless Environment Training Facility (WET-F). Astronaut John H. Casper (in background), mission commander, awaits the actual training to begin. Brown and Casper will join four other astronauts for nine days aboard the Space Shuttle Endeavour next month.

  8. Video- Astronauts Don Pettit and Ken Bowersox Paint Water Onboard the International Space Station

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Saturday Morning Science, the science of opportunity series of applied experiments and demonstrations, performed aboard the International Space Station (ISS) by Expedition 6 astronaut Dr. Don Pettit, revealed some remarkable findings. Science begets art in this video as Dr. Pettit and commander Ken Bowersox demonstrate two dimensional diffusion using food coloring in a film of water when they created an intriguing birdlike image. Dr. Pettit wonders aloud 'It makes us wonder what Matisse could do with a medium like this.'

  9. Don E. Detmer and the American Medical Informatics Association: An Appreciation

    PubMed Central

    Shortliffe, Edward H.; Bates, David W.; Bloomrosen, Meryl; Greenwood, Karen; Safran, Charles; Steen, Elaine B.; Tang, Paul C.; Williamson, Jeffrey J.

    2009-01-01

    Don E. Detmer has served as President and Chief Executive Officer of the American Medical Informatics Association (AMIA) for the past five years, helping to set a course for the organization and demonstrating remarkable leadership as AMIA has evolved into a vibrant and influential professional association. On the occasion of Dr. Detmer's retirement, we fondly reflect on his professional life and his many contributions to biomedical informatics and, more generally, to health care in the U.S. and globally. PMID:19574463

  10. STS-39 MS Bluford dons EMU lower torso in preparation for dive in JSC's WETF

    NASA Technical Reports Server (NTRS)

    1990-01-01

    STS-39 Mission Specialist (MS) Guion S. Bluford, wearing liquid cooling and ventilation garment (LCVG), has just donned the extravehicular mobility unit (EMU) lower torso in preparation for an underwater simulation in JSC's Weightless Environment Training Facility (WETF) Bldg 29. When fully suited in his EMU, Bluford will be lowered into the water by a hoist device for the underwater rehearsal of contingency extravehicular activity (EVA) procedures.

  11. QuickTox™ Kit for QuickScan DON3 (Vomitoxin) Method Modification.

    PubMed

    Polakowski, Sergiusz; Davis, Alan H; Albert, Andre L; Gow, Brendan

    2015-01-01

    Lateral flow technology and a reader-based system are used for quantitative determination of deoxynivalenol (DON), also known as vomitoxin, residues in cereal grain commodities by the QuickTox Kit for QuickScan DON (Vomitoxin). The assay has been modified, and a study was conducted in support of a Performance Tested MethodSM (PTM) Modification. The modified assay employs identical biologic reagents as used previously (PTM No. 121202). Compared to the PTM certified product, the new assay uses modified device architecture. Multiple kits and catalog numbers were required in the original kit reflecting the necessity for matrix specific calibration curves affixed to assay strips. A single calibration curve and kit are utilized in the new product; extraction volumes used in sample preparation are varied to accommodate multiple sample types. Extracts are clarified by filtration or settling depending on the sample type. Filtration was used for matrixes examined in these studies. With the original product, the extract was mixed 1:1 with DB1 buffer followed by the addition of the strip which was developed for 10 min. The new product dilutes extracts five-fold offline in DB6 buffer; an aliquot of the dilution is moved to a reaction vial followed by strip development time for 3 min. The new assay performance was evaluated for linearity, robustness, selectivity (inclusivity), lot-to-lot consistency, and both internal and third party matrix studies. All DON positive samples yielded results within previously defined acceptable ranges with dose-dependent correlation values of R2 greater than 0.97 in linearity and internal and external matrix studies. Inclusivity data indicated detection of DON along with acetyl derivatives, glucoside-conjugate, and Nivalenol. Robustness studies showed within range results upon co-variation of multiple user interface parameters, and lot-to-lot consistency challenges demonstrated acceptable results across five manufactured lots.

  12. Bioethics of the refusal of blood by Jehovah's Witnesses: Part 3. A proposal for a don't-ask-don't-tell policy.

    PubMed Central

    Muramoto, O

    1999-01-01

    Of growing concern over Jehovah's Witnesses' (JWs) refusal of blood is the intrusion of the religious organisation into its members' personal decision making about medical care. The organisation currently may apply severe religious sanctions to JWs who opt for certain forms of blood-based treatment. While the doctrine may be maintained as the unchangeable "law of God", the autonomy of individual JW patients could still be protected by the organisation modifying its current policy so that it strictly adheres to the right of privacy regarding personal medical information. The author proposes that the controlling religious organisation adopt a "don't-ask-don't-tell" policy, which assures JWs that they would neither be asked nor compelled to reveal personal medical information, either to one another or to the church organisation. This would relieve patients of the fear of breach of medical confidentiality and ensure a truly autonomous decision on blood-based treatments without fear of organisational control or sanction. PMID:10635499

  13. Chemotaxonomic diagnostics: combining sucrose-water agar with TLC to discriminate Fusarium graminearum 3-acetyl-DON and 15-acetyl-DON chemotypes.

    PubMed

    Vujanovic, Vladimir; Ben Mansour, Manel

    2011-11-01

    Twelve randomly-selected isolates of Fusarium graminearum that produce 3-acetyl-deoxynivalenol (3-ADON) or 15-acetyl-deoxynivalenol (15-ADON) were screened by thin-layer chromatography (TLC) for their ability to produce ADON and zearalenone (ZEA) mycotoxins when grown on water agar containing different concentrations of sucrose. The results showed the ability of the F. graminearum 3-ADON chemotype population to produce DON and ZEA at a lower concentration range of sucrose (5-7%) compared with the 15-ADON chemotype (30-40%). The former distinction allows for sucrose-water agar to be employed as a rapid and simple differential medium, where two separate sucrose-gradient concentrations discriminate 3-ADON from 15-ADON populations. In the light of the shift in sugar concentrations occurring during the process of grain formation and maturation, the difference in mycotoxin production between the two populations is discussed with respect to predicting Fusarium head blight (FHB) epidemiology and accumulation of DON and ZEA.

  14. "The herbs that have the property of healing...,": the phytotherapy in Don Quixote.

    PubMed

    López-Muñoz, Francisco; Alamo, Cecilio; García-García, Pilar

    2006-07-19

    Don Quixote, the most outstanding novel of the Spanish literature, represents a documentary source widely used among those specialists who intend to deepen in the knowledge of the late Renaissance society. In this sense, Don Quixote has been also studied from a medical perspective, including a general therapeutical view (oils, ointments, balms, poultices, syrups and other pharmacy preparations). We have tackled Don Quixote from the phytotherapeutic and ethnopharmacological perspective, a barely explored field. In this work, we intend to study the medicinal plants used during the Cervantine time for the treatment de multiples diseases (sedatives like opium, laxatives and emetics like hellebore, tonics and irritants) and we analyze the specific herbal therapies (balms, purgatives and emetics, ointments and poultices), which Cervantes reveals to us in his novel. Among them, the rhubarb root (Rheum spp. or Rumex spp.) should be highlighted, as well as the seeds of gopher spurge (Euphorbia lathyris), chicory (Cichorium intybus) and rosemary (Rosmarinus officinalis), primary component of the famous Balsam of Fierabras. Also, we have examined the possible scientific influences, which might have inspired Cervantes in this field, mainly the work of Andrés Laguna (Dioscorides' Materia Medica).

  15. Relative Distributions of Dreissena bugensis and Dreissena polymorpha in the Lower Don River System, Russia

    NASA Astrophysics Data System (ADS)

    Zhulidov, A. V.; Pavlov, D. F.; Nalepa, T. F.; Scherbina, G. H.; Zhulidov, D. A.; Gurtovaya, T. Yu.

    2004-07-01

    A survey was conducted in the lower Don River system in Russia to confirm the presence of Dreissena bugensis, and to compare its distribution relative to that of Dreissena polymorpha. In 1999 and 2001-2002, dreissenid mussels were collected at 15 sites in the main river, in connecting reservoirs, and in a major tributary, the Manych River. Collections were made near stations where long-term monitoring data on total mineral (sum of principal ions) and calcium content were available. Both dreissenid species were found at all sites, with D. bugensis comprising 4-75% of all dreissenids at individual sites. D. bugensis was relatively more abundant than D. polymorpha in the Manych River where total mineral and calcium content was significantly higher than in the Don River, suggesting the two species may have different calcium requirements. Examination of archived samples indicated that D. bugensis was present in the Don River system as early as the 1980s, presenting the unresolved enigma of why D. bugensis has not displaced D. polymorpha as the dominant species as typically found over shorter time periods in other water bodies. (

  16. Change and persistence in land surface phenologies of the Don and Dnieper river basins

    NASA Astrophysics Data System (ADS)

    Kovalskyy, V.; Henebry, G. M.

    2009-10-01

    The formal collapse of the Soviet Union at the end of 1991 produced major socio-economic and institutional dislocations across the agricultural sector. The picture of broad scale patterns produced by these transformations continues to be discovered. We examine here the patterns of land surface phenology (LSP) within two key river basins—Don and Dnieper—using AVHRR (Advanced Very High Resolution Radiometer) data from 1982 to 2000 and MODIS (Moderate Resolution Imaging Spectroradiometer) data from 2001 to 2007. We report on the temporal persistence and change of LSPs as summarized by seasonal integration of NDVI (normalized difference vegetation index) time series using accumulated growing degree-days (GDDI NDVI). Three land cover super-classes—forest lands, agricultural lands, and shrub lands—constitute 96% of the land area within the basins. All three in both basins exhibit unidirectional increases in AVHRR GDDI NDVI between the Soviet and post-Soviet epochs. During the MODIS era (2001-2007), different socio-economic trajectories in Ukraine and Russia appear to have led to divergences in the LSPs of the agricultural lands in the two basins. Interannual variation in the shrub lands of the Don river basin has increased since 2000. This is due in part to the better signal-to-noise ratio of the MODIS sensor, but may also be due to a regional drought affecting the Don basin more than the Dnieper basin.

  17. Liu et al. suspect that Zhu et al. (2015) may have underestimated dissolved organic nitrogen (N) but overestimated total particulate N in wet deposition in China.

    PubMed

    Liu, Xuejun; Xu, Wen; Pan, Yuepeng; Du, Enzai

    2015-07-01

    In a recent publication in the journal Science of the Total Environment, Zhu et al. (2015) reported the composition, spatial patterns, and factors influencing atmospheric wet nitrogen (N) deposition based on one year's data from 41-monitoring sites in China. We suspect their results may largely underestimate dissolved organic N (DON) but overestimate total particulate N (TPN) in wet deposition due to the uncertainty resulting from the sampling, storage and analysis methods in their study. Our suspicions are based mainly on our experience from earlier measurements and the literature. We therefore suggest that enhanced data quality control on atmospheric N deposition measurements should be taken into account in future studies.

  18. Spatio-temporal variability of dissolved organic nitrogen (DON), carbon (DOC), and nutrients in the Nile River, Egypt.

    PubMed

    Badr, El-Sayed A

    2016-10-01

    Increases in human activity have resulted in enhanced anthropogenic inputs of nitrogen (N) and carbon (C) into the Nile River. The Damietta Branch of the Nile is subject to inputs from industrial, agricultural, and domestic wastewater. This study investigated the distribution and seasonality of dissolved organic nitrogen (DON), dissolved organic carbon (DOC), and nutrients in the Nile Damietta Branch. Water samples were collected from 24 sites between May 2009 and February 2010. Dissolved organic nitrogen concentrations averaged 251 ± 115 μg/l, with a range of 90.2-671 μg/l, and contributed 40.8 ± 17.7 % to the total dissolved nitrogen (TDN) pool. Relative to autumn and winter, DON was a larger fraction of the TDN pool during spring and summer indicating the influence of bacterioplankton on the nitrogen cycle. Concentrations of DOC ranged from 2.23 to 11.3 mg/l with an average of 5.15 ± 2.36 mg/l, reflecting a high organic matter load from anthropogenic sources within the study area, and were highest during autumn. Higher values of biochemical oxygen demand (BOD), chemical oxygen demand (COD), DON, nitrate, and phosphate occurred downstream of the Damietta Branch and were probably due to anthropogenic inputs to the Nile from the Damietta district. A bacterial incubation experiment indicated that 52.1-95.0 % of DON was utilized by bacteria within 21 days. The decrease in DON concentration was accompanied by an increase in nitrate concentration of 54.8-87.3 %, presumably through DON mineralization. Based on these results, we recommend that water quality assessments consider DON and DOC, as their omission may result in an underestimation of the total organic matter load and impact.

  19. /Cu-Al System

    NASA Astrophysics Data System (ADS)

    Kish, Orel; Froumin, Natalya; Aizenshtein, Michael; Frage, Nachum

    2014-05-01

    Wettability and interfacial interaction of the Ta2O5/Cu-Al system were studied. Pure Cu does not wet the Ta2O5 substrate, and improved spreading is achieved when relatively a high fraction of the active element (~40 at.% Al) was added. The Al2O3 and AlTaO4 phases were observed at the Ta2O5/Cu-Al interface. A thermodynamic evaluation allowed us to suggest that the lack of wetting bellow 40 at.% Al is due to the presence of a native oxide, which covers the drop. The conditions of the native oxide decomposition and the formation of the volatile Al2O suboxide strongly depend on the vacuum level during sessile drop experiments and the composition of the Cu-Al alloy. In our case, Al contents greater than 40% provides thermodynamic conditions for the formation of Al2O (as a result of Al reaction with Al2O3) and the drop spreading. It was suggested that the final contact angle in the Ta2O5/Cu-Al system (50°) is determined by Ta adsorption on the newly formed alumina interlayer.

  20. ALS (Amyotrophic Lateral Sclerosis)

    MedlinePlus

    ... risk factors for veterans include exposure to lead, pesticides, and other environmental toxins. ALS is recognized as ... from scientific studies suggests that both genetics and environment play a role in the development of ALS. ...

  1. Lou Gehrig's Disease (ALS)

    MedlinePlus

    ... 1930s. People in England and Australia call ALS motor neurone disease (MND). The French refer to it ... about ALS in 1869. Lou Gehrig's disease damages motor neurons in the brain and spinal cord. Motor ...

  2. Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights

    SciTech Connect

    Katika, Madhumohan R.; Hendriksen, Peter J.M.; Shao, Jia; Loveren, Henk van; Peijnenburg, Ad

    2012-10-01

    Deoxynivalenol (DON) or vomitoxin is a commonly encountered type-B trichothecene mycotoxin, produced by Fusarium species predominantly found in cereals and grains. DON is known to exert toxic effects on the gastrointestinal, reproductive and neuroendocrine systems, and particularly on the immune system. Depending on dose and exposure time, it can either stimulate or suppress immune function. The main objective of this study was to obtain a deeper insight into DON-induced effects on lymphoid cells. For this, we exposed the human T-lymphocyte cell line Jurkat and human peripheral blood mononuclear cells (PBMCs) to various concentrations of DON for various times and examined gene expression changes by DNA microarray analysis. Jurkat cells were exposed to 0.25 and 0.5 μM DON for 3, 6 and 24 h. Biological interpretation of the microarray data indicated that DON affects various processes in these cells: It upregulates genes involved in ribosome structure and function, RNA/protein synthesis and processing, endoplasmic reticulum (ER) stress, calcium-mediated signaling, mitochondrial function, oxidative stress, the NFAT and NF-κB/TNF-α pathways, T cell activation and apoptosis. The effects of DON on the expression of genes involved in ER stress, NFAT activation and apoptosis were confirmed by qRT-PCR. Other biochemical experiments confirmed that DON activates calcium-dependent proteins such as calcineurin and M-calpain that are known to be involved in T cell activation and apoptosis. Induction of T cell activation was also confirmed by demonstrating that DON activates NFATC1 and induces its translocation from the cytoplasm to the nucleus. For the gene expression profiling of PBMCs, cells were exposed to 2 and 4 μM DON for 6 and 24 h. Comparison of the Jurkat microarray data with those obtained with PBMCs showed that most of the processes affected by DON in the Jurkat cell line were also affected in the PBMCs. -- Highlights: ► The human T cell line Jurkat and human

  3. [Occurrence of Fusarium strains and their mycotoxins in corn silage. 7. Formation of deoxynivalenol (DON) in a silage corn plot artificially inoculated with Fusarium culmorum and the effect of silaging on the stability of the DON formed].

    PubMed

    Lepom, P; Knabe, O; Baath, H

    1990-10-01

    The formation of deoxynivalenol in a maize plot inoculated with Fusarium culmorum was studied over a growing season. Already three weeks after inoculation 4.9 mg/kg of DON were measured in the infected ears. The toxin concentration increased continuously up to harvest after eight weeks to a value of 261 mg/kg. Ensilage experiments in laboratory scale silos have shown that the DON content of naturally contaminated corn-cob-mix was not reduced during the ensilage process. It was concluded that infection of maize plants by toxin-producing Fusarium species followed by DON production in the field seems to be the most probable way of contamination of maize silage with this mycotoxin.

  4. Discovery of a Centrifugal Magnetosphere around the He-Strong Magnetic B1 Star ALS 3694

    NASA Astrophysics Data System (ADS)

    Shultz, M.; Wade, G.; Rivinius, T.; Sikora, J.; MiMeS Collaboration

    2016-11-01

    We report the results of 6 nights of Canada-France-Hawaii Telescope spectropolarimetric ESPaDOnS observations of the He-strong, magnetic B1 type star ALS 3694. The longitudinal magnetic field is approximately 2 kG in all 6 observations, showing essentially no variation between nights. The Hα line displays variable emission on all nights, peaking at high velocities (˜3 v sin i). Given the presence of a strong (Bd>6 kG) magnetic field, and the similarity of the emission profile to that of other magnetic B-type stars, we interpret the emission as a consequence of a centrifugal magnetosphere.

  5. Regional economic impacts of current and proposed management alternatives for Don Edwards National Wildlife Refuge

    USGS Publications Warehouse

    Richardson, Leslie; Huber, Chris; Koontz, Lynne

    2012-01-01

    The National Wildlife Refuge System Improvement Act of 1997 requires all units of the National Wildlife Refuge System to be managed under a Comprehensive Conservation Plan. The Comprehensive Conservation Plan must describe the desired future conditions of a Refuge and provide long-range guidance and management direction to achieve refuge purposes. The Don Edwards San Francisco Bay National Wildlife Refuge, located at the south end of California's San Francisco Bay and one of seven refuges in the San Francisco Bay National Wildlife Refuge Complex, is in the process of developing a range of management goals, objectives, and strategies for the Comprehensive Conservation Plan. The Comprehensive Conservation Plan must contain an analysis of expected effects associated with current and proposed Refuge management strategies. For Refuge Comprehensive Conservation Plan planning, a regional economic analysis provides a means of estimating how current management (No Action Alternative) and proposed management activities (alternatives) affect the local economy. This type of analysis provides two critical pieces of information: (1) it illustrates the Don Edwards San Francisco Bay National Wildlife Refuge's contribution to the local community, and (2) it can help in determining whether economic effects are or are not a real concern in choosing among management alternatives. This report first presents a description of the local community and economy near the Don Edwards San Francisco Bay National Wildlife Refuge. Next, the methods used to conduct a regional economic impact analysis are described. An analysis of the final Comprehensive Conservation Plan management strategies that could affect stakeholders, residents, and the local economy is then presented. The management activities of economic concern in this analysis are: * Spending in the local community by Refuge visitors; * Refuge personnel salary spending; and * Refuge purchases of goods and services within the local

  6. A Volume Celebrating the Life of Don Colless, Australian Dipterist 1922–2012.

    PubMed

    Yeates, David K; Cranston, Peter S

    2013-01-01

    Donald Henry Colless (24 August 1922–16 February 2012) was a taxonomist at the Australian National Insect Collection (ANIC) from 1960 until his retirement in 1987. He continued working in ANIC as an Honorary Fellow until his death in 2012. Don’s main scientific interests were in the taxonomy and biology of true flies, and in the theory of phylogenetic reconstruction and classification. Don was trained in entomology at the University of Sydney, and spent nearly two decades of his early career in Asia studying mosquitoes and disease transmission, first in the Army during the Second World War in New Guinea and Borneo (1942–45), then after the war in North Borneo (1947–1952) and as a lecturer in the Department of Parasitology at the University of Malaya (1952–1960) in Singapore. We list the 127 scientific papers and book chapters that Don published during his scientific career that spanned 64 years. Six of these papers were published in the prestigious international journal Nature, and he was Chief Curator of the ANIC from 1971–1977. Don had extremely broad taxonomic interests, publishing on the taxonomy of 18 families of Diptera that spanned the phylogenetic breadth of the order. He described as new to science the fly families Perissommatidae and Axiniidae, thirteen new genera and over 120 species and, with David McAlpine, authored the Diptera chapters in both editions of The Insects of Australia (Melbourne University Press, 1970 and 1991). He published a number of influential critiques of cladistic theory in the 1960's and 1970's, and advocated a phenetic approach to the discovery of taxonomic groups, and phylogenetic reconstruction.

  7. Early Activation of MAPK p44/42 Is Partially Involved in DON-Induced Disruption of the Intestinal Barrier Function and Tight Junction Network

    PubMed Central

    Springler, Alexandra; Hessenberger, Sabine; Schatzmayr, Gerd; Mayer, Elisabeth

    2016-01-01

    Deoxynivalenol (DON), produced by the plant pathogens Fusarium graminearum and Fusarium culmorum, is one of the most common mycotoxins, contaminating cereal and cereal-derived products. Although worldwide contamination of food and feed poses health threats to humans and animals, pigs are particularly susceptible to this mycotoxin. DON derivatives, such as deepoxy-deoxynivalenol (DOM-1), are produced by bacterial transformation of certain intestinal bacteria, which are naturally occurring or applied as feed additives. Intestinal epithelial cells are the initial barrier against these food- and feed-borne toxins. The present study confirms DON-induced activation of MAPK p44/42 and inhibition of p44/42 by MAPK-inhibitor U0126 monoethanolate. Influence of DON and DOM-1 on transepithelial electrical resistance (TEER), viability and expression of seven tight junction proteins (TJ), as well as the potential of U0126 to counteract DON-induced effects, was assessed. While DOM-1 showed no effect, DON significantly reduced TEER of differentiated IPEC-J2 and decreased expression of claudin-1 and -3, while leaving claudin-4; ZO-1, -2, and -3 and occludin unaffected. Inhibition of p44/42 counteracted DON-induced TEER decrease and restored claudin-3, but not claudin-1 expression. Therefore, effects of DON on TEER and claudin-3 are at least partially p44/42 mediated, while effects on viability and claudin-1 are likely mediated via alternative pathways. PMID:27618100

  8. Effect of deoxynivalenol (DON) on growing pigs and its modification by modified yeast cell wall or modified yeast cell wall and bentonite.

    PubMed

    Shehata, S; Richter, W; Schuster, M; Lindermayer, H

    2004-03-01

    The study examined effect of two adsorbents on the toxicity of Deoxynivalenol (DON) in growing pigs in a feeding trial. 24 male growing pigs (average initial body weight 11.5 kg) were assigned to one of six dietary treatments: control (uncontaminated diet); control + 0.5% adsorbent I; DON contaminated diet (1.73 mg/kg); DON contaminated diet + 0.5% adsorbent I; control + 0.5% adsorbent II and DON contaminated diet + 0.5% adsorbent II. Two digestibility trials were conducted on the second and fourth week of the feeding period with a sampling period of 7 days to determine the digestibility of the nutrients and the amounts of DON in faeces and urine. At the end of the experiments, the pigs were slaughtered, followed by blood haematology and biochemi analys. These data suggest that the addition of 0.5% modified yeast cell wall or a combination of modified yeast cell wall and bentonite to the naturally DON - contaminated diets reduce the effect of DON on the immune system of pigs but do not play an significant role in detoxification of DON in growing pigs.

  9. 5 CFR 839.702 - How do these rules apply to me if I don't have an election right under the FERCCA, but I did have...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false How do these rules apply to me if I don't have an election right under the FERCCA, but I did have a qualifying retirement coverage error? 839.702... don't have an election right under the FERCCA, but I did have a qualifying retirement coverage error...

  10. 5 CFR 839.702 - How do these rules apply to me if I don't have an election right under the FERCCA, but I did have...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false How do these rules apply to me if I don't have an election right under the FERCCA, but I did have a qualifying retirement coverage error? 839.702... don't have an election right under the FERCCA, but I did have a qualifying retirement coverage error...

  11. 5 CFR 839.702 - How do these rules apply to me if I don't have an election right under the FERCCA, but I did have...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false How do these rules apply to me if I don't have an election right under the FERCCA, but I did have a qualifying retirement coverage error? 839.702... don't have an election right under the FERCCA, but I did have a qualifying retirement coverage error...

  12. 5 CFR 839.702 - How do these rules apply to me if I don't have an election right under the FERCCA, but I did have...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false How do these rules apply to me if I don't have an election right under the FERCCA, but I did have a qualifying retirement coverage error? 839.702... don't have an election right under the FERCCA, but I did have a qualifying retirement coverage error...

  13. 5 CFR 839.702 - How do these rules apply to me if I don't have an election right under the FERCCA, but I did have...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false How do these rules apply to me if I don't have an election right under the FERCCA, but I did have a qualifying retirement coverage error? 839.702... don't have an election right under the FERCCA, but I did have a qualifying retirement coverage error...

  14. When Staff Don't Do What They're Supposed to Do: Identifying and Responding to Reasons behind Poor Performance

    ERIC Educational Resources Information Center

    Gersten, Mary

    2009-01-01

    Why don't employees always do what they're supposed to do? The reasons are often as ambiguous to them as they are to their supervisors. Different roles come with different perceptions. Understanding and finding solutions will help one create an approach to staff development that will target the reasons why staff don't always perform at their best.…

  15. Early Activation of MAPK p44/42 Is Partially Involved in DON-Induced Disruption of the Intestinal Barrier Function and Tight Junction Network.

    PubMed

    Springler, Alexandra; Hessenberger, Sabine; Schatzmayr, Gerd; Mayer, Elisabeth

    2016-09-08

    Deoxynivalenol (DON), produced by the plant pathogens Fusarium graminearum and Fusarium culmorum, is one of the most common mycotoxins, contaminating cereal and cereal-derived products. Although worldwide contamination of food and feed poses health threats to humans and animals, pigs are particularly susceptible to this mycotoxin. DON derivatives, such as deepoxy-deoxynivalenol (DOM-1), are produced by bacterial transformation of certain intestinal bacteria, which are naturally occurring or applied as feed additives. Intestinal epithelial cells are the initial barrier against these food- and feed-borne toxins. The present study confirms DON-induced activation of MAPK p44/42 and inhibition of p44/42 by MAPK-inhibitor U0126 monoethanolate. Influence of DON and DOM-1 on transepithelial electrical resistance (TEER), viability and expression of seven tight junction proteins (TJ), as well as the potential of U0126 to counteract DON-induced effects, was assessed. While DOM-1 showed no effect, DON significantly reduced TEER of differentiated IPEC-J2 and decreased expression of claudin-1 and -3, while leaving claudin-4; ZO-1, -2, and -3 and occludin unaffected. Inhibition of p44/42 counteracted DON-induced TEER decrease and restored claudin-3, but not claudin-1 expression. Therefore, effects of DON on TEER and claudin-3 are at least partially p44/42 mediated, while effects on viability and claudin-1 are likely mediated via alternative pathways.

  16. STS-38 Mission Specialist (MS) Carl J. Meade dons EMU in JSC's WETF Bldg 29

    NASA Technical Reports Server (NTRS)

    1990-01-01

    STS-38 Mission Specialist (MS) Carl J. Meade, wearing liquid cooling and ventilation garment (LCVG) and extravehicular mobility unit (EMU) lower torso, crouches under EMU upper torso. Technicians extend the EMU sleeves as Meade reaches into upper torso during suit donning in JSC's Weightless Environment Training Facility (WETF) Bldg 29. Positioned on the WETF platform at pool side, Meade is preparing for an underwater extravehicular activity (EVA) simulation. During the training exercise, Meade will rehearse contingency EVA procedures for the STS-38 mission aboard Atlantis, Orbiter Vehicle (OV) 104.

  17. STS-57 MS2 Sherlock dons EMU upper torso with technicians' help at JSC's WETF

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-57 Mission Specialist 2 (MS2) Nancy J. Sherlock, wearing the liquid cooling and ventilation garment (LCVG) and an extravehicular mobility unit (EMU) lower torso, squats under the EMU upper torso and prepares to raise her arms into the sleeves. Technicians stand on either side of Sherlock and are ready to assist her in donning the upper torso. When fully suited the platform Sherlock is on will be lowered into the 25 foot deep pool located in JSC's Weightless Environment Training Facility (WETF) Bldg 29. During the underwater simulation, Sherlock will practice extravehicular activity (EVA) procedures.

  18. Astronaut Dunbar adjusts CCA before donning EMU helmet in JSC's WETF Bldg 29

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Astronaut Bonnie J. Dunbar, wearing extravehicular mobility unit (EMU), adjusts the communications carrier assembly (CCA) ('Snoopy' cap) microphones before donning EMU helmet. Dunbar is preparing for an underwater simulation in JSC's Weightless Environment Training Facility (WETF) Bldg 29 pool. When fully suited, Dunbar will be lowered into the pool to rehearse planned and contingency extravehicular activities (EVAs). NOTE: Since this photograph was taken, Dunbar has been named as the payload commander (PLC) for STS-50 United States Microgravity Laboratory 1 (USML-1) mission aboard Columbia, Orbiter Vehicle (OV) 102.

  19. Pilot Fullerton dons anti-g and ejection escape suit (EES) on middeck

    NASA Image and Video Library

    1982-03-31

    S82-28922 (30 March 1982) --- Astronaut C. Gordon Fullerton, STS-3 pilot, floats upside down in the zero-gravity environment of the middeck area of the Earth-orbiting space shuttle Columbia as he dons a modified USAF high altitude pressure garment. The brownish ejection/escape suit is used by the astronauts at launch and entry. Most of the remainder of their mission time, they are attired in a blue constant-wear garment. Astronaut Jack R. Lousma, crew commander, took this picture with a 35mm camera. The crew spent eight full days in the reusable spacecraft, a shuttle record. Photo credit: NASA

  20. Astronaut Dunbar adjusts CCA before donning EMU helmet in JSC's WETF Bldg 29

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Astronaut Bonnie J. Dunbar, wearing extravehicular mobility unit (EMU), adjusts the communications carrier assembly (CCA) ('Snoopy' cap) microphones before donning EMU helmet. Dunbar is preparing for an underwater simulation in JSC's Weightless Environment Training Facility (WETF) Bldg 29 pool. When fully suited, Dunbar will be lowered into the pool to rehearse planned and contingency extravehicular activities (EVAs). NOTE: Since this photograph was taken, Dunbar has been named as the payload commander (PLC) for STS-50 United States Microgravity Laboratory 1 (USML-1) mission aboard Columbia, Orbiter Vehicle (OV) 102.

  1. STS-38 Mission Specialist (MS) Carl J. Meade dons EMU in JSC's WETF Bldg 29

    NASA Image and Video Library

    1990-02-14

    STS-38 Mission Specialist (MS) Carl J. Meade, wearing liquid cooling and ventilation garment (LCVG) and extravehicular mobility unit (EMU) lower torso, crouches under EMU upper torso. Technicians extend the EMU sleeves as Meade reaches into upper torso during suit donning in JSC's Weightless Environment Training Facility (WETF) Bldg 29. Positioned on the WETF platform at pool side, Meade is preparing for an underwater extravehicular activity (EVA) simulation. During the training exercise, Meade will rehearse contingency EVA procedures for the STS-38 mission aboard Atlantis, Orbiter Vehicle (OV) 104.

  2. Astronaut Jones donning EMU during space walk simulations for STS-59

    NASA Image and Video Library

    1993-08-16

    Astronaut Thomas D. Jones, mission specialist, dons a space suit prior to participating in contingency space walk simulations at the JSC Weightless Environment Training Facility (WETF). Jones is assisted by Frank Hernandez (left) and suit technician Charles Hudson of Hamilton Standard. Jones suit is weighted to that he can achieve a neutrally buoyant state once under water. Extravehicular tasks are not planned for the STS-59 mission, but a number of chores are rehearsed in case of failure of remote systems to perform those jobs.

  3. Pilot Fullerton dons EES anti-gravity suit lower torso on middeck

    NASA Image and Video Library

    1982-03-30

    STS003-23-161 (24 March 1982) --- Astronaut C. Gordon Fullerton, STS-3 pilot, dons an olive drab inner garment which complements the space shuttle Extravehicular Mobility Unit (EMU) spacesuit. Since there are no plans for an extravehicular activity (EVA) on the flight, Fullerton is just getting some practice time ?in the field? as he is aboard the Earth-orbiting Columbia. He is in the middeck area of the vehicle. The photograph was taken with a 35mm camera by astronaut Jack R. Lousma, STS-3 commander. Photo credit: NASA

  4. What We Don't Know about the Beginning of the Universe

    NASA Astrophysics Data System (ADS)

    Carroll, Sean

    2017-01-01

    The history of the universe from a few seconds after the Big Bang is fairly well-understood, but what happened before then is largely mysterious. Inflation is a popular paradigm, but raises a number of conceptual problems, both in its conception and its implementation. Before inflation, we don't know whether there was a true beginning or whether the universe has lasted eternally; which alternative is correct may come down to dimly-understood features of quantum gravity. I will discuss these issues, how they relate to later-universe cosmology, and the prospects for future progress.

  5. STS-32 MS Dunbar dons EMU upper torso prior to WETF exercises

    NASA Image and Video Library

    1989-08-14

    S89-41597 (Nov 1989) --- Astronaut Bonnie J. Dunbar, wearing an extravehicular mobility unit (EMU) spacesuit, prepares to don gloves and subsequently a helmet and to be lowered by a hoist device for a session of underwater training in the Johnson Space Center's weightless environment training facility (WET-F). Minutes later, Astronauts Dunbar and G. David Low, mission specialists, were neutrally buoyant in the nearby 25-ft. deep pool simulating a contingency extravehicular activity (EVA) for the scheduled December 1989 STS-32 mission. There are no scheduled EVAs for the crew, whose main missions are to retrieve the Long Duration Exposure Facility (LDEF) and to deploy a Syncom satellite.

  6. A Compression Kit of a Stocking and Three Superimposed Leggings Is Easy to Don and Dose Adjustable.

    PubMed

    Luder, C; Dziunycz, P; Omid, N; Radetzki, A-L; Lang, C; Hübner, M; Hafner, J

    2016-03-01

    Forty percent of patients with chronic venous insufficiency (CVI) do not wear their indicated and prescribed compression stockings. Difficulties in donning and a feeling of constraint are the most common reasons for non-adherence. The aim was to develop a compression stocking system that is easy to don and dose adjustable. A modular compression stocking kit composed of an understocking and three superimposable leggings (SLLLs) was developed. Substocking pressures (P) at the thinnest part above the ankle (cB level) were 17 mm (understocking) + 15 + 10 + 10 mmHg (3 superimposed leggings; Hatra method). Twenty healthy subjects and 20 patients over 65 years with CVI donned the SLLL compression kit. P was measured in vivo (Picopress method) at the transition of the Achilles tendon to the calf muscle (level cB1) during rest and ankle movements (DSI; dynamic stiffness index) and compared with a strong compression stocking of 40 mmHg (S40). Twenty (20/20) patients aged over 65 with CVI (C4-6) successfully donned the SLLL compression kit without aid, compared with 12 (12/20) who were able to don the S40 without aid (p = .02). In vivo resting P at level cB1 was 34.3 mmHg (SLLL) compared with 37.3 mmHg (S40) (p = .1). The DSI was 16.1 (SLLL) compared with 17.9 (p = .79; S40; CVI group). The physical properties of the SLLL compression stocking kit correspond to the characteristics of a strong stocking at rest and exercise (DSI). The donning success rate is excellent (100%). A further potential advantage is that the SLLL leg compression kit is dose adjustable, according to indication or patient tolerance. Wearing comfort over periods of several days and clinical effectiveness need to be investigated in future trials. Copyright © 2015 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

  7. Patterns of dissolved organic carbon (DOC) and nitrogen (DON) fluxes in deciduous and coniferous forests under historic high nitrogen deposition

    NASA Astrophysics Data System (ADS)

    Sleutel, S.; Vandenbruwane, J.; de Schrijver, A.; Wuyts, K.; Moeskops, B.; Verheyen, K.; de Neve, S.

    2009-07-01

    Numerous recent studies have indicated that dissolved organic carbon (DOC) and nitrogen (DON) play an important role in C and N cycling in natural ecosystems, and have shown that N deposition alters the concentrations and fluxes of dissolved organic substances and may increase leaching losses from forests. Our study was set up to accurately quantify concentrations and flux patterns of DOC, DON and dissolved inorganic nitrogen (DIN) in deciduous and coniferous forest in Flanders under historical high nitrogen deposition. We measured DOC, DON and DIN concentrations at two weekly intervals in a silver birch (SB) stand, a corsican pine (CP) stand and a pine stand with higher N deposition (CPN), and used the SWAP model (calibrated with PEST) for generating accurate water and matter fluxes. The input with precipitation was an important source of DON, but not for DOC. Release of DOC from the forest floor was minimally affected by forest type, but higher N deposition (CPN stand) caused an 82% increase of DOC release from the forest floor. Adsorption to mineral soil material rich in iron and/or aluminum oxyhydroxides was suggested to be the most important process removing DOC from the soil solution, responsible for substantial retention (67-84%) of DOC entering the mineral soil profile with forest floor leachate. Generally, DON was less reactive (i.e. less removal from the soil solution) than DOC, resulting in decreasing DOC/DON ratios with soil depth. We found increased DOC retention in the mineral soil as a result of higher N deposition (84 kg N ha-1 yr-1 additional DOC retention in CPN compared to CP). Overall DON leaching losses were 2.2, 3.3 and 5.0 kg N ha-1 yr-1 for SB, CP and CPN, respectively, contributing between 9-28% to total dissolved N (TDN) leaching. DON loss from SB and CP was not much higher than from unpolluted forests, and its relative contribution to TDN leaching was mainly determined by (large) differences in DIN leaching. The large TDN leaching losses

  8. Open source pipeline for ESPaDOnS reduction and analysis

    NASA Astrophysics Data System (ADS)

    Martioli, Eder; Teeple, Doug; Manset, Nadine; Devost, Daniel; Withington, Kanoa; Venne, Andre; Tannock, Megan

    2012-09-01

    OPERA is a Canada-France-Hawaii Telescope (CFHT) open source collaborative software project currently under development for an ESPaDOnS echelle spectro-polarimetric image reduction pipeline. OPERA is designed to be fully automated, performing calibrations and reduction, producing one-dimensional intensity and polarimetric spectra. The calibrations are performed on two-dimensional images. Spectra are extracted using an optimal extraction algorithm. While primarily designed for CFHT ESPaDOnS data, the pipeline is being written to be extensible to other echelle spectrographs. A primary design goal is to make use of fast, modern object-oriented technologies. Processing is controlled by a harness, which manages a set of processing modules, that make use of a collection of native OPERA software libraries and standard external software libraries. The harness and modules are completely parametrized by site configuration and instrument parameters. The software is open- ended, permitting users of OPERA to extend the pipeline capabilities. All these features have been designed to provide a portable infrastructure that facilitates collaborative development, code re-usability and extensibility. OPERA is free software with support for both GNU/Linux and MacOSX platforms. The pipeline is hosted on SourceForge under the name "opera-pipeline".

  9. Why Models Don%3CU%2B2019%3Et Forecast.

    SciTech Connect

    McNamara, Laura A.

    2010-08-01

    The title of this paper, Why Models Don't Forecast, has a deceptively simple answer: models don't forecast because people forecast. Yet this statement has significant implications for computational social modeling and simulation in national security decision making. Specifically, it points to the need for robust approaches to the problem of how people and organizations develop, deploy, and use computational modeling and simulation technologies. In the next twenty or so pages, I argue that the challenge of evaluating computational social modeling and simulation technologies extends far beyond verification and validation, and should include the relationship between a simulation technology and the people and organizations using it. This challenge of evaluation is not just one of usability and usefulness for technologies, but extends to the assessment of how new modeling and simulation technologies shape human and organizational judgment. The robust and systematic evaluation of organizational decision making processes, and the role of computational modeling and simulation technologies therein, is a critical problem for the organizations who promote, fund, develop, and seek to use computational social science tools, methods, and techniques in high-consequence decision making.

  10. Change and Persistence in Land Surface Phenologies in the Don and Dnieper River Basins

    NASA Astrophysics Data System (ADS)

    Kovalskyy, V.; Henebry, G. M.

    2006-12-01

    The formal collapse of the Soviet Union at the end of 1991 produced major socioeconomic and institutional dislocations across the agricultural sector. We examine the patterns of land surface phenology (LSP) within two key river basins in Ukraine and Russia from 1982-2000 using AVHRR datasets (PAL and GIMMS) and from 2001-2005 using MODIS products. Originating south of Moscow, the Don River flows for nearly 2000 km south through the Central Russian Upland and discharges into the Gulf of Taganrog at the northern end of the Sea of Azov. The Don River Basin covers more than 45,000,000 ha of which roughly 83% is used for agricultural purposes. The Dnieper stretches from Russia through Belarus and Ukraine before flowing into the northern Black Sea at Kherson. The Dnieper River Basin covers more than 53,000,000 ha of which roughly 87% is used for agricultural purposes. Five very large surface water reservoirs occur in these basins; they cover at total of 862,000 ha or 17% of the impounded surface area in the Former Soviet Union. We report the temporal persistence of LSPs modeled using NDVI, WDRVI, and EVI2 within MODIS/IGBP land cover classes and map where significant shifts in LSPs have occurred during the past two decades.

  11. Artificial radionuclides in sediments of the Don River Estuary and Azov Sea.

    PubMed

    Matishov, Genady G; Matishov, Dimitry G; Namjatov, Alexey A; Carroll, JoLynn; Dahle, Salve

    2002-01-01

    The Don River Estuary-Azov Sea system is an extension of the shallow continental shelf area of the Black Sea. A large data set of artificial radionuclides in bottom sediments of the Azov Sea has been compiled in order to examine the storage and migration of radionuclides within this highly restricted inland sea and to estimate the annual dose received by individuals in the local population who regularly consume fish. In recent years (1997-1999), the radionuclide content of surface sediments has been: 137Cs < or = 0.5-100 Bq/kg d.w. (mean = 33.8 +/- 25.9 Bq/kg d.w., n = 57), 90Sr = 0.2-5.7 Bq/kg d.w. (mean = 2.1 +/- 1.4 Bq/kg d.w., n = 34) and 239,240Pu = 0.31-0.51 Bq/kg d.w. (n = 2). In general, 137Cs activities increase with distance from the mouth of the Don River and correlate negatively with sediment grain size (r2 = 0.77, n = 21). The annual 137Cs-derived dose received by an individual through the trophic chain water-fish-humans (approximately 10(-6) Sv/yr) is well below regulatory recommended limits, indicating that current levels of radioactivity in the environment pose no threat to commercial fisheries operations for the bordering nations of Russia and Ukraine.

  12. Why we don't get sick: the within-host population dynamics of bacterial infections.

    PubMed

    Levin, B R; Antia, R

    2001-05-11

    To pathogenic microparasites (viruses, bacteria, protozoa, or fungi), we and other mammals (living organisms at large) are little more than soft, thin-walled flasks of culture media. Almost every time we eat, brush our teeth, scrape our skin, have sex, get bitten by insects, and inhale, we are confronted with populations of microbes that are capable of colonizing the mucosa lining our orifices and alimentary tract and proliferating in fluids and cells within us. Nevertheless, we rarely get sick, much less succumb to these infections. The massive numbers of bacteria and other micro- and not-so-micro organisms that abound and replicate in our alimentary tract and cover our skin and the mucosa lining our orifices normally maintain their communities in seemingly peaceful coexistence with the somatic cells that define us. Why don't these microbes invade and proliferate in the culture media within the soft, thin-walled flask that envelops us? Why don't they cause disease and lead to our rapid demise?

  13. [The virtue of that precious balsam...: approach to Don Quixote from the psychopharmacological perspective].

    PubMed

    Lopez-Munoz, F; Garcia-Garcia, P; Alamo, C

    2007-01-01

    The most outstanding novel of the Spanish literature, Don Quixote, represents the source to which the different specialists who intend to deepen their knowledge of the late Renaissance society usually address. This masterpiece of Miguel de Cervantes has been frequently approached from the psychopathological perspective to obtain a psychiatric diagnosis of its main character, Alonso Quijano. Also, other clinical approaches from the traumatological and general therapeutical view (oils, ointments, balms and other pharmacy preparations) have been frequent. We have tackled Don Quixote from the psychopharmacological perspective, a barely explored field. In this work, we intend to study the therapeutical cures used during the Cervantine time for the treatment of insane and mentally disturbed people (sedatives like opium, laxatives like hellebore, tonics, irritants and surgical techniques like bloodlettings and ) and we analyze the limited and unspecific therapies, mainly of herbal origin (balms, purgatives and emetics), which Cervantes reveals to us in his novel. Among them, rhubarb root (Rumex alpinus), seeds of spurge (Euphorbia lathyris), St. John's Wort (Hypericum perforatum), main ingredient of Aparicio's oil, and rosemary (Rosmarinus officinalis), primary component of the famous balsam of Fierabras, should be highlighted. We have also examined the possible scientific influences which might have inspired Cervantes in this field, mainly the works of Juan Huarte de San Juan The examination of men's wits and the one of Andres Laguna Dioscorides' materia medica.

  14. Finite element analysis of donning procedure of a prosthetic transfemoral socket.

    PubMed

    Lacroix, Damien; Patiño, Juan Fernando Ramírez

    2011-12-01

    Lower limb amputation is a severe psychological and physical event in a patient. A prosthetic solution can be provided but should respond to a patient-specific need to accommodate for the geometrical and biomechanical specificities. A new approach to calculate the stress-strain state at the interaction between the socket and the stump of five transfemoral amputees is presented. In this study the socket donning procedure is modeled using an explicit finite element method based on the patient-specific geometry obtained from CT and laser scan data. Over stumps the mean maximum pressure is 4 kPa (SD 1.7) and the mean maximum shear stresses are 1.4 kPa (SD 0.6) and 0.6 kPa (SD 0.3) in longitudinal and circumferential directions, respectively. Locations of the maximum values are according to pressure zones at the sockets. The stress-strain states obtained in this study can be considered more reliable than others, since there are normal and tangential stresses associated to the socket donning procedure.

  15. 'Don't play the butter notes': jazz in medical education.

    PubMed

    Bradner, Melissa; Harper, Darryl V; Ryan, Mark H; Vanderbilt, Allison A

    2016-01-01

    Jazz has influenced world music and culture globally - attesting to its universal truths of surviving, enduring, and triumphing over tragedy. This begs the question, what can we glean in medical education from this philosophy of jazz mentoring? Despite our training to understand disease and illness in branching logic diagrams, the human experience of illness is still best understood when told as a story. Stories like music have tempos, pauses, and silences. Often they are not linear but wrap around the past, future, and back to the present, frustrating the novice and the experienced clinician in documenting the history of present illness. The first mentoring lesson Hancock discusses is from a time he felt stuck with his playing - his sound was routine. Miles Davis told him in a low husky murmur, 'Don't play the butter notes'. In medical education, 'don't play the butter notes' suggests not undervaluing the metacognition and reflective aspects of medical training that need to be fostered during the early years of clinical teaching years.

  16. When Marcel Mauss's Essai sur le Don becomes The Gift: variations on the theme of solidarity.

    PubMed

    Bateman, Simone

    2016-12-01

    Since the early 1970s, Marcel Mauss's Essai sur le Don (1923), translated into English as The Gift in 1954, has been a standard reference in the social science and bioethical literature on the use of human body parts and substances for medical and research purposes. At that time, three social scientists-political scientist Richard Titmuss in the United Kingdom and sociologist Renée C. Fox working with historian Judith Swazey in the United States-had the idea of using this concept to highlight the fundamental structure of the biomedical practices they were studying, respectively, blood donation, and hemodialysis and organ transplantation. The fact that these first applications of Mauss's essay should emerge in English- rather than in French-speaking countries raises the question of what the translation of the essay, and notably of the word don as gift, may have to do with this fact. Reading Mauss in translation undoubtedly inspired a seminal approach to interpreting medical and research practices based on bodily giving. This article posits that something may have also been lost: a much broader concept of giving with unquestionable links to the Durkheimian concept of solidarity, which Mauss conceptualizes not only as an obligation but also as a liberty to give.

  17. Don Quixote, Machiavelli, and Robin Hood: public health practice, past and present.

    PubMed Central

    Mullan, F

    2000-01-01

    Since the mid-19th century, when the first formal health departments were established in the United States, commissioners, directors, and secretaries of public health have functioned as senior members of the staffs of public executives, mayors, governors, and presidents. They have provided important political, managerial, and scientific leadership to agencies of government that have played increasingly important roles in national life, from the sanitary revolution of the 19th century to the prevention of HIV/AIDS and the control of tobacco use today. Although public health officials come from a variety of backgrounds and oversee agencies of varied size and composition, there are philosophical themes that describe and define the commonality of their work. These themes are captured metaphorically by 3 celebrated figures: Don Quixote, Machiavelli, and Robin Hood. By turns, the public health official functions as a determined idealist (Don Quixote), a cunning political strategist (Machiavelli), and an agent who redistributes resources from the wealthier sectors of society to the less well off (Robin Hood.) All 3 personae are important, but, it is argued, Robin Hood is the most endangered. PMID:10800417

  18. Don Quixote, Machiavelli, and Robin Hood: public health practice, past and present.

    PubMed

    Mullan, F

    2000-05-01

    Since the mid-19th century, when the first formal health departments were established in the United States, commissioners, directors, and secretaries of public health have functioned as senior members of the staffs of public executives, mayors, governors, and presidents. They have provided important political, managerial, and scientific leadership to agencies of government that have played increasingly important roles in national life, from the sanitary revolution of the 19th century to the prevention of HIV/AIDS and the control of tobacco use today. Although public health officials come from a variety of backgrounds and oversee agencies of varied size and composition, there are philosophical themes that describe and define the commonality of their work. These themes are captured metaphorically by 3 celebrated figures: Don Quixote, Machiavelli, and Robin Hood. By turns, the public health official functions as a determined idealist (Don Quixote), a cunning political strategist (Machiavelli), and an agent who redistributes resources from the wealthier sectors of society to the less well off (Robin Hood.) All 3 personae are important, but, it is argued, Robin Hood is the most endangered.

  19. Genetic testing in ALS

    PubMed Central

    McLaughlin, Russell L.; Heverin, Mark; Thorpe, Owen; Abrahams, Sharon; Al-Chalabi, Ammar; Hardiman, Orla

    2017-01-01

    Objective: To determine the degree of consensus among clinicians on the clinical use of genetic testing in amyotrophic lateral sclerosis (ALS) and the factors that determine decision-making. Methods: ALS researchers worldwide were invited to participate in a detailed online survey to determine their attitudes and practices relating to genetic testing. Results: Responses from 167 clinicians from 21 different countries were analyzed. The majority of respondents (73.3%) do not consider that there is a consensus definition of familial ALS (FALS). Fifty-seven percent consider a family history of frontotemporal dementia and 48.5% the presence of a known ALS genetic mutation as sufficient for a diagnosis of FALS. Most respondents (90.2%) offer genetic testing to patients they define as having FALS and 49.4% to patients with sporadic ALS. Four main genes (SOD1, C9orf72, TARDBP, and FUS) are commonly tested. A total of 55.2% of respondents would seek genetic testing if they had personally received a diagnosis of ALS. Forty-two percent never offer presymptomatic testing to family members of patients with FALS. Responses varied between ALS specialists and nonspecialists and based on the number of new patients seen per year. Conclusions: There is a lack of consensus among clinicians as to the definition of FALS. Substantial variation exists in attitude and practices related to genetic testing of patients and presymptomatic testing of their relatives across geographic regions and between experienced specialists in ALS and nonspecialists. PMID:28159885

  20. Don't Call Them Dropouts: Understanding the Experiences of Young People Who Leave High School before Graduation

    ERIC Educational Resources Information Center

    Hynes, Michelle

    2014-01-01

    "Don't Call Them Dropouts" adds to the large and growing body of research about why some young people fail to complete high school on the traditional four-year timeline. While a high school diploma is only a starting line for adult success, it has become increasingly clear that it is crucial for taking the next steps in college and…

  1. The Emperor Has No Clothes: Teaching about Race and Racism to People Who Don't Want to Know

    ERIC Educational Resources Information Center

    Okun, Tema Jon

    2010-01-01

    "The Emperor Has No Clothes: Teaching About Race and Racism to People Who Don't Want to Know" is designed to offer both practical and theoretical grounding for leaders and teachers interested in effectively addressing racism as well as other oppressive constructs. The dissertation offers an overview of the role of western culture in maintaining…

  2. The Inquiry into the Education of Don Henry and His Subsequent Death in the Spanish Civil War.

    ERIC Educational Resources Information Center

    Schamel, Charles E.; Schamel, Wynell B.

    1998-01-01

    Summarizes the story of Don Henry, a student at the University of Kansas in the 1930s, focusing on how he became a communist after he left home and later went to fight in the the Spanish Civil War. Provides a teaching activity on the role of universities in influencing students and their beliefs. (CMK)

  3. 13 CFR 123.510 - What if you don't use your Military Reservist EIDL funds as authorized?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Military Reservist EIDL funds as authorized? 123.510 Section 123.510 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Military Reservist Economic Injury Disaster Loans § 123.510 What if you don't use your Military Reservist EIDL funds as authorized? If your small business does...

  4. The Emperor Has No Clothes: Teaching about Race and Racism to People Who Don't Want to Know

    ERIC Educational Resources Information Center

    Okun, Tema Jon

    2010-01-01

    "The Emperor Has No Clothes: Teaching About Race and Racism to People Who Don't Want to Know" is designed to offer both practical and theoretical grounding for leaders and teachers interested in effectively addressing racism as well as other oppressive constructs. The dissertation offers an overview of the role of western culture in maintaining…

  5. Cornell Produces a Video of Safety Dos and Don'ts for the YouTube Set

    ERIC Educational Resources Information Center

    Lipka, Sara

    2008-01-01

    Don't drink too much, download pirated files, light candles, or prop open doors. Warnings like those pervade the weighty work of admonition known as the student handbook. However, Allen J. Bova wonders, "Who ever reads that?" So Mr. Bova, director of risk management and insurance at Cornell University, tried to reach students with a…

  6. 77 FR 23673 - Notice of Stakeholder Meeting: Industry Roundtable-DON/USDA/DOE/DOT-FAA Advanced Drop-In Biofuels...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Department of the Navy Notice of Stakeholder Meeting: Industry Roundtable--DON/USDA/DOE/ DOT-FAA Advanced.... Federal government representatives will also be able to hear from stakeholders as to their abilities...

  7. Get Thee Away, Knight, Be Gone, Cavalier: English Translations of the Biscayan Squire Episode in "Don Quixote de la Mancha"

    ERIC Educational Resources Information Center

    Azevedo, Milton M.

    2009-01-01

    This article analyzes twelve English translations of the Biscayan squire's speech ("Don Quijote de la Mancha", Chapter Eight) published between 1612 and 2000. The solutions found fall into three categories, namely (a) using standard English and risking misrepresenting the style of the original and omitting relevant cultural connotations, (b) using…

  8. Get Thee Away, Knight, Be Gone, Cavalier: English Translations of the Biscayan Squire Episode in "Don Quixote de la Mancha"

    ERIC Educational Resources Information Center

    Azevedo, Milton M.

    2009-01-01

    This article analyzes twelve English translations of the Biscayan squire's speech ("Don Quijote de la Mancha", Chapter Eight) published between 1612 and 2000. The solutions found fall into three categories, namely (a) using standard English and risking misrepresenting the style of the original and omitting relevant cultural connotations, (b) using…

  9. Cornell Produces a Video of Safety Dos and Don'ts for the YouTube Set

    ERIC Educational Resources Information Center

    Lipka, Sara

    2008-01-01

    Don't drink too much, download pirated files, light candles, or prop open doors. Warnings like those pervade the weighty work of admonition known as the student handbook. However, Allen J. Bova wonders, "Who ever reads that?" So Mr. Bova, director of risk management and insurance at Cornell University, tried to reach students with a…

  10. "Don't Tell Me No; I Tell You No!": Facilitating Self-Control in Infants and Toddlers

    ERIC Educational Resources Information Center

    Tu, Tsunghui; Lash, Martha

    2007-01-01

    "Don't tell me no; I tell you no!" is a classic example of a frustrated mother reprimanding her toddler. Certainly, other parents and even teachers of young children experience and/or understand this sentiment as they pursue the slow process of teaching infants and toddlers self-control and self-regulation. This article illuminates how teachers…

  11. Beat the Odds...Why Some Schools With Latino Children Beat the Odds and Others Don't

    ERIC Educational Resources Information Center

    Waits, Mary Jo; Campbell, Heather E.; Gau, Rebecca; Jacobs, Ellen; Rex, Tom; Hess, Robert K.

    2006-01-01

    Using the methodology of Jim Collins from his book "Good to Great: Why Some Companies Make the Leap...and Other's Don't," the authors of this report, under the sponsorship of the Center for the Future of Arizona and the Morrison Institute, found 12 elementary and middle schools in Arizona--schools whose students are mostly Latino and…

  12. Treatment of Nonresponse Items on Scale Validation: What "Don't Know" Responses Indicate about College Readiness

    ERIC Educational Resources Information Center

    Lombardi, Allison; Seburn, Mary; Conley, David

    2011-01-01

    In this study, Don't Know/Not Applicable (DK/NA) responses on a measure of academic behaviors associated with college readiness for high school students were treated with: (a) casewise deletion, (b) scale inclusion at the lowest level, and (c) imputation using E/M algorithm. Significant differences in mean responses according to treatment…

  13. Ventilatory Control in ALS

    PubMed Central

    Nichols, Nicole L.; Van Dyke, J.; Nashold, L.; Satriotomo, I.; Suzuki, M.; Mitchell, G.S.

    2015-01-01

    Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease. ALS selectively causes degeneration in upper and lower (spinal) motor neurons, leading to muscle weakness, paralysis and death by ventilatory failure. Although ventilatory failure is generally the cause of death in ALS, little is known concerning the impact of this disorder on respiratory motor neurons, the consequences of respiratory motor neuron cell death, or the ability of the respiratory control system to “fight back” via mechanisms of compensatory respiratory plasticity. Here we review known effects of ALS on breathing, including possible effects on rhythm generation, respiratory motor neurons, and their target organs: the respiratory muscles. We consider evidence for spontaneous compensatory plasticity, preserving breathing well into disease progression despite dramatic loss of spinal respiratory motor neurons. Finally, we review current and potential therapeutic approaches directed toward preserving the capacity to breathe in ALS patients. PMID:23692930

  14. Spring summer cycling of DOC, DON and inorganic N in a highly seasonal system encompassing the Northeast Water Polynya, 1993

    NASA Astrophysics Data System (ADS)

    Skoog, Annelie; Lara, Ruben; Kattner, Gerhard

    2001-12-01

    Dissolved organic nitrogen (DON), dissolved organic carbon (DOC) and inorganic nutrient concentrations were determined in samples from an area encompassing the Northeast Water Polynya from June to August 1993. In June, still ice-covered polynya area surface waters (PySW) had significantly higher ( p<0.05) DOC concentrations (110 μM, n=68) than surface water outside the polynya area (96 μM, n=6). Melting ice and ice algae are suggested as DOC sources. DOC concentrations found in this study are consistent with other studies showing higher DOC concentrations in the Arctic than in other ocean areas. As the productive season progressed, DOC concentrations in Polynya surface water (PySW) decreased ( p<0.05) from 110 to 105 μM, while DON concentrations increased ( p<0.05) from 5.6 to 6.1 μM, causing a significant decrease ( p<0.05) in the C : N ratios of DOM from spring (C : N ratio 20) to summer (C : N ratio 17). We found a significant ( p<0.05) decrease in the DOM C : N ratio in all water masses within the polynya area as the productive season progressed. DON was the largest fraction of total dissolved nitrogen (TDN) in PySW and surface waters outside the polynya area. TDN was calculated as the sum of DON, nitrate, nitrite and ammonium concentrations. DON increased ( p<0.05) from 62% to 73% of TDN in PySW from spring to summer, a result of increasing DON concentrations and decreasing inorganic nitrogen concentrations over the productive season. The seasonal accumulation of DON and the corresponding decrease in nitrate concentrations in waters with primary production indicate that it is important to take the DON pool into account when estimating export production from nitrate concentration decreases in surface waters. PySW TDN concentrations decreased ( p<0.05) from 9.1 ( n=61) to 8.6 μM ( n=60) from spring (May 25 through June 19) to summer (July 1 through July 27). The seasonal decrease in surface water TDN concentrations corresponded to increases in TDN

  15. Vegetation and climate controls on potential CO2, DOC and DON production in northern latitude soils

    USGS Publications Warehouse

    Neff, J.C.; Hooper, D.U.

    2002-01-01

    Climatic change may influence decomposition dynamics in arctic and boreal ecosystems, affecting both atmospheric CO2 levels, and the flux of dissolved organic carbon (DOC) and dissolved organic nitrogen (DON) to aquatic systems. In this study, we investigated landscape-scale controls on potential production of these compounds using a one-year laboratory incubation at two temperatures (10?? and 30??C). We measured the release of CO2, DOC and DON from tundra soils collected from a variety of vegetation types and climatic regimes: tussock tundra at four sites along a latitudinal gradient from the interior to the north slope of Alaska, and soils from additional vegetation types at two of those sites (upland spruce at Fairbanks, and wet sedge and shrub tundra at Toolik Lake in northern Alaska). Vegetation type strongly influenced carbon fluxes. The highest CO2 and DOC release at the high incubation temperature occurred in the soils of shrub tundra communities. Tussock tundra soils exhibited the next highest DOC fluxes followed by spruce and wet sedge tundra soils, respectively. Of the fluxes, CO2 showed the greatest sensitivity to incubation temperatures and vegetation type, followed by DOC. DON fluxes were less variable. Total CO2 and total DOC release were positively correlated, with DOC fluxes approximately 10% of total CO2 fluxes. The ratio of CO2 production to DOC release varied significantly across vegetation types with Tussock soils producing an average of four times as much CO2 per unit DOC released compared to Spruce soils from the Fairbanks site. Sites in this study released 80-370 mg CO2-C g soil C-1 and 5-46 mg DOC g soil C-1 at high temperatures. The magnitude of these fluxes indicates that arctic carbon pools contain a large proportion of labile carbon that could be easily decomposed given optimal conditions. The size of this labile pool ranged between 9 and 41% of soil carbon on a g soil C basis, with most variation related to vegetation type rather than

  16. A new translational repression element and unusual transcriptional control regulate expression of don juan during Drosophila spermatogenesis.

    PubMed

    Blümer, Nicole; Schreiter, Kay; Hempel, Leonie; Santel, Ansgar; Hollmann, Martin; Schäfer, Mireille A; Renkawitz-Pohl, Renate

    2002-01-01

    The Drosophila don juan (dj) gene encodes a basic protein that is expressed solely in the male germline and shows structural similarities to the linker histone H1. Don Juan is located in two different subcellular structures: in the nucleus during the phase of chromatin condensation and later in the mitochondrial derivatives starting with spermatid individualization. The don juan gene is transcribed in primary spermatocytes under the control of 23 bp upstream in combination with downstream sequences. During meiotic stages and in early spermatid stages don juan mRNA is translationally repressed for several days. Analysis of male sterile mutants which fail to undergo meiosis shows that release of dj mRNA from translational repression is independent of meiosis. In gel retardation assays 60 nucleotides at the end of the dj leader form four major complexes with proteins that were extracted from testes but not with protein extracts from ovaries. Transformation studies prove that in vivo 35 bp within that region of the dj mRNA is essential to confer translational repression. UV cross-linking studies show that a 62 kDa protein specifically binds to the same region within the 5' untranslated region. The dj translational repression element, TRE, is distinct from the translational control element, TCE, described earlier for all members of the Mst(3)CGP gene family. Moreover, expression studies in several male sterile mutants reveal that don juan mRNA is translated in earlier developmental stages during sperm morphogenesis than the Mst(3)CGP mRNAs. This proves that translational activation of dormant mRNAs in spermatogenesis occurs at different time-points which are characteristic for each gene, an essential feature for coordinated sperm morphogenesis.

  17. Fate of Fusarium mycotoxins in the cereal product supply chain: the deoxynivalenol (DON) case within industrial bread-making technology.

    PubMed

    Bergamini, E; Catellani, D; Dall'asta, C; Galaverna, G; Dossena, A; Marchelli, R; Suman, M

    2010-05-01

    Fusarium mycotoxins are a relevant problem in the cereal supply chain at a worldwide level, with wheat, maize and barley being the main contaminated crops. Mould growth can happen in the pre-harvest phase and also during transport and storage due to ineffective drying conditions. Among Fusarium toxins, deoxynivalenol (DON) is considered the most important contaminant in wheat due to its widespread occurrence. In the last years the European Food Safety Authority (EFSA) and the European Commission have frequently expressed opinions on Fusarium toxins, setting limits, regulations and guidelines in order to reduce their levels in raw materials and food commodities. In particular, European legislation (Reg. 1881/2006) sets the maximum limit for DON in flour and bread as 750 and 500 microg kg(-1) respectively. Relatively few studies have taken into account the loss of trichothecenes during processing, focusing on how processing factors may influence their degradation. In particular, the description of DON behaviour during bread-making is very difficult, since complex physico-chemical modifications occur during the transformation of the raw ingredients into the final product. In the present study, we studied how DON concentration may be influenced by modifying bread-making parameters, with a special emphasis on the fermentation and baking stages, starting from a naturally contaminated flour at both pilot and industrial scales. Exploiting the power of a Design of Experiments (DoE) approach to consider the great complexity of the studied system, the obtained model shows satisfying goodness-of-fit and prediction, suggesting that the baking step (time/temperature ranges) is crucial for minimizing native DON level in bread.

  18. ALS2 mutations

    PubMed Central

    Schneider, Susanne A.; Carr, Lucinda; Deuschl, Guenther; Hopfner, Franziska; Stamelou, Maria; Wood, Nicholas W.; Bhatia, Kailash P.

    2014-01-01

    Objective: To determine the genetic etiology in 2 consanguineous families who presented a novel phenotype of autosomal recessive juvenile amyotrophic lateral sclerosis associated with generalized dystonia. Methods: A combination of homozygosity mapping and whole-exome sequencing in the first family and Sanger sequencing of candidate genes in the second family were used. Results: Both families were found to have homozygous loss-of-function mutations in the amyotrophic lateral sclerosis 2 (juvenile) (ALS2) gene. Conclusions: We report generalized dystonia and cerebellar signs in association with ALS2-related disease. We suggest that the ALS2 gene should be screened for mutations in patients who present with a similar phenotype. PMID:24562058

  19. STS-55 MS3 Harris dons EMU with technician's assistance in JSC's WETF Bldg 29

    NASA Technical Reports Server (NTRS)

    1991-01-01

    STS-55 Columbia, Orbiter Vehicle (OV) 102, Mission Specialist 3 (MS3) Bernard A. Harris, Jr, partially suited in his extravehicular mobility unit (EMU), and a technician take a break from suiting procedures to watch nearby activity (out of frame) in JSC's Weightless Environment Training Facility (WETF) Bldg 29. Harris has donned the EMU upper and lower torsos which are not yet connected at the waist ring. Once fully suited in the EMU, Harris will be lowered into the WETF's 25-foot pool for an underwater contingency extravehicular activity (EVA) simulation. There is no scheduled EVA for the 1993 flight but each spaceflight crew includes astronauts trained for a variety of contingency tasks that could require exiting the shirt-sleeve environment of a Shuttle's cabin.

  20. Extreme saline water advection into the Don River delta and ice advections into Kerch Strait

    NASA Astrophysics Data System (ADS)

    Matishov, G. G.

    2015-11-01

    Analysis of such extreme natural phenomena as inflow of saline transformed waters from the Black Sea into the Don River delta, ice drift, and some others, which have been observed in the Sea of Azov in the recent years, is performed. The process and consequences of the ice movement from the Sea of Azov into Kerch Strait under the effect of hurricane-force NE winds is characterized. Data on the salinity and water level changes during the intensive westerly winds are given. The relationship between salinity and water level during episodes of the surges and downsurges is found. Recommendations for organizing the monitoring measures, intended to increase the accuracy of forecasting emergency situations in the Gulf of Taganrog, Sea of Azov, are presented.

  1. Heavy metals in soils and plants of the don river estuary and the Taganrog Bay coast

    NASA Astrophysics Data System (ADS)

    Minkina, T. M.; Fedorov, Yu. A.; Nevidomskaya, D. G.; Pol'shina, T. N.; Mandzhieva, S. S.; Chaplygin, V. A.

    2017-09-01

    Natural and anthropogenic factors determining the distribution and accumulation features of Pb, Cu, Zn, Cr, Ni, Cd, Mn, and As in the soil-plant system of the Don River estuary and the northern and southern Russian coasts of Taganrog Bay estuary have been studied. High mobility of Cu, Zn, Pb, and Cd has been revealed in alluvial soils. This is confirmed by the significant bioavailability of Cu, Zn, and, to a lesser degree, Cd and the technophily of Pb, which are accumulated in tissues of macrophytic plants. Statistically significant positive correlations have been found between the mobile forms of Cu, Zn, Cd, and Mn in the soil and the accumulation of metals in plants. Impact zones with increased metal contents in aquatic ecosystems can be revealed by bioindication from the morphofunctional parameters of macrophytic plants (with Typha L. as an example).

  2. STS-54 MS3 Susan J. Helms dons EMU for underwater simulation in JSC's WETF

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-54 Endeavour, Orbiter Vehicle (OV) 105, Mission Specialist 3 (MS3) Susan J. Helms, wearing extravehicular mobility unit (EMU), prepares for an underwater simulation in JSC's Weightless Environment Training Facility (WETF) Bldg 29. Helmetless, Helms gets some assistance from a technician to complete the donning of her spacesuit. Though not assigned to the scheduled extravehicular activity (EVA), Helms is trained in the WETF. She will aid the assigned EVA crewmembers in their EVA preparations and will serve a backup role. Wearing this high fidelity training version of the EMU, Helms was later lowered into the WETF's 25-foot deep pool via the platform she is standing on. The pressurized suit is weighted so as to allow Helms to achieve neutral buoyancy and simulate the various chores of the spacewalk.

  3. "Don juan-fracture" as a hint to aortic isthmus rupture.

    PubMed

    Suksompong, Sirilak; von Bormann, Benno

    2014-01-01

    We report a case of thoracic aortic rupture after blunt trauma in a 23-year-old male patient. The initial investigation found no external injury or bleeding, only a slightly widened mediastinum and a broken left calcaneus. Abdominal lavage was negative, biochemistry was normal, and breathing and oxygenation were not compromised. When changing his position during diagnostics, the patient all of a sudden developed cardiac arrest and typical signs of hypovolemic shock. An immediate sternotomy was done without any further diagnostics on suspicion of aortic isthmus injury. A circular avulsion at the ligamentum arteriosum was found as assumed and repaired under cardiopulmonary bypass. The patient left the hospital for rehabilitation after 12 days in adequate health status. Biodynamics of blunt trauma after high-speed frontal impact and the relationship between calcaneus fracture, called "Don-Juan fracture," and aortic rupture at the site of ligamentum arteriosum are discussed.

  4. An isotopic and chemical study of Lake Vanda and Don Juan Pond, Antarctica

    NASA Astrophysics Data System (ADS)

    Friedman, I.; Rafter, A.; Smith, G. I.

    Temperature measurements made in Lake Vanda and in the lake subbottom sediments show that the high temperatures in the lake are not due to geothermal heat flow, but are probably trapped solar energy. On the basis of Sr-87/86 ratios the salts in Lake Vanda can be derived by a mixture of 58% weathered rock plus 42% from sea water or precipitation. Loss of efflorescences high in sodium, potassium and magnesium by high winds can yield the salt compositions present in both Lake Vanda and Don Juan Pond. From isotopic data on deuterium, O-18, C-13, Sr-87/86, S-34 as well as from chemical data on Lake Vanda waters, interstitial brines contained in the subsurface sediment and C-14 dates a lake history is proposed.

  5. Expedition 6 Crew Interviews: Don Pettit, Flight Engineer 2/ International Space Station (ISS) Science Officer (SO)

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Expedition 6 member Don Pettit (Flight Engineer 2/ International Space Station (ISS) Science Officer (SO)) is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut and his career path. Pettit, who had been training as a backup crewmember, discusses the importance of training backups for ISS missions. He gives details on the goals and significance of the ISS, regarding experiments in various scientific disciplines such as the life sciences and physical sciences. Pettit also comments on the value of conducting experiments under microgravity. He also gives an overview of the ISS program to date, including the ongoing construction, international aspects, and the routines of ISS crewmembers who inhabit the station for four months at a time. He gives a cursory description of crew transfer procedures that will take place when STS-113 docks with ISS to drop off Pettit and the rest of Expedition 6, and retrieve the Expedition 5 crew.

  6. STS-65 crewmembers don LES equipment for MAIL Bldg 9NE egress training

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Attired in partial pressure launch and entry suits (LESs), two mission specialists and a payload specialist for the STS-65 International Microgravity Laboratory 2 (IML-2) mission, prepare to rehearse emergency escape procedures and other flight tasks. Technicians help crewmembers (left to right) Mission Specialist (MS) Leroy Chiao, MS Donald A. Thomas, and Japanese Payload Specialist Chiaki Mukai don LES equipment. Mukai represents Japan's National Space Development Agency (NASDA). In addition to the emergency egress training, the seven crewmembers also simulated their duties for launch and entry phases of the scheduled 13-day flight aboard Columbia, Orbiter Vehicle (OV) 102. The training session was held in Johnson Space Center's (JSC's) Mockup and Integration Laboratory (MAIL) Bldg 9NE.

  7. A phantom extinction? New insights into extinction dynamics of the Don-hare Lepus tanaiticus.

    PubMed

    Prost, S; Knapp, M; Flemmig, J; Hufthammer, A K; Kosintsev, P; Stiller, M; Hofreiter, M

    2010-09-01

    The Pleistocene to Holocene transition was accompanied by a worldwide extinction event affecting numerous mammalian species. Several species such as the woolly mammoth and the giant deer survived this extinction wave, only to go extinct a few thousand years later during the Holocene. Another example for such a Holocene extinction is the Don-hare, Lepus tanaiticus, which inhabited the Russian plains during the late glacial. After being slowly replaced by the extant mountain hare (Lepus timidus), it eventually went extinct during the middle Holocene. Here, we report the phylogenetic relationship of L. tanaiticus and L. timidus based on a 339-basepair (bp) fragment of the mitochondrial D-loop. Phylogenetic tree- and network reconstructions do not support L. tanaiticus and L. timidus being different species. Rather, we suggest that the two taxa represent different morphotypes of a single species and the extinction of 'L. tanaiticus' represents the disappearance of a local morphotype rather than the extinction of a species.

  8. [Age dynamics of population gene pool of the Crimean pine (Pinus pallasiana D. Don) in Crimea].

    PubMed

    Korshikov, I I; Mudrik, E A; Krasnoshtan, O V; Velikorid'ko, T I; Kalafat, L A; Podgornyĭ, D Iu

    2011-01-01

    Polymorphism of young (14-16 years), middle-aged (70-80 years) and old (120-150 years) plants and their seed embryos has been studied using 20 and 10 allozyme loci correspondingly in the population of Pinus pallasiana D. Don from Mountain Crimea. It was revealed that the old-aged trees had significantly lower level of expected heterozygosity than the young plants. The level of observed heterozygosity of embryos of the uneven-aged plants was slightly different among the embryo samples and significantly lower than in the samples of maternal trees. Supernumerary homozygotation of the embryos is caused by low level of cross-pollination in three studied samples of plants (t(m) = 0,537-0,637).

  9. Don't wear blinders when choosing a hazardous waste carrier

    SciTech Connect

    Krukowski, J.

    1993-11-01

    When choosing a hazardous waste carrier, it may not hurt to be a little paranoid. Start by subjecting a potential hauler to a barrage of questions. And, say people experienced in the selection process, don't be shy about demanding the hauler support its answers with documentation. Then verify information with third-party sources such as state regulators or insurance companies. Never, ever, take anything for granted. Your company's future is as stake. Regulations have appeared in the last two decades to help avoid bad experiences. The Resource Conservation and Recovery Act (RCRA) created a manifest system to ensure hazardous waste gets to where it is supposed to be going, and the Hazardous Materials Transportation Act (HMTA), with amendments, set Department of Transportation (DOT) standards for carriers and shippers (usually the generators) of hazardous materials and wastes.

  10. Managing Pessimistic, Gloomy, and Cynical Employees: Twenty-Five Do's and Don'ts.

    PubMed

    Hills, Laura

    2015-01-01

    Every medical practice manager has to deal with a certain amount of employee pessimism at times. But one overly pessimistic employee can spread his or her negativity to the entire medical practice team if the manager doesn't intervene. This article suggests practical strategies managers can use to deal effectively with a pessimistic, defeatist, gloomy, or cynical employee. It describes two kinds of pessimism medical practice managers may encounter and offers 25 specific management do's and don'ts for managing a pessimist. This article also offers managers guidance for firing a pessimistic employee, including sample language they can use. It provides 10 self-care strategies for practice managers so they can keep themselves from succumbing to an employee's negativity. It also suggests eight ways that pessimism can hurt the medical practice team and describes five kinds of negative thinking managers may encounter. Finally, this article explores defensive pessimism theory and the surprising benefits for managers of some pessimistic thinking.

  11. Metasomatic processes within the fertile lithospheric Mantle beneath Don Camilo, Santa Cruz, Argentina

    NASA Astrophysics Data System (ADS)

    Ntaflos, Th.; Mundl, A.; Bjerg, E. A.; Tschegg, C.; Kosler, J.

    2009-04-01

    Mantle xenoliths in alkalibasalts from Don Camilo, an area located at the North margin of the Deseado Massif in Patagonia, comprise mainly spinel-bearing lherzolites and dunites as well as less common harburgites, wehrlites, clinopyroxenites and gabbros. Spinel-lherzolites and harzburgites have protogranular textures whereas dunites have equigranular to equigranular tabular textures. There are two kinds of dunites: mantle and cumulate dunites. The olivine mg# in the mantle dunites vary within a narrow range from 90.5 to 91.5 and the NiO content from, 0.39 to 0.42 wt. %, whereas in the cumulate dunites the mg# ranges from 87 to 90.5 and the NiO content from 0.22 to 0.40 wt. %. Both types of dunite contain fine grained interstitial diopside. Hydrous phases, besides one sample that contains amphibole, were so far not found. The spinel peridotites have Primitive Mantle normalized (PM) whole rock REE abundances depleted in LREE [(La/Yb)N=0.34-0.85)] and the dunites are LREE enriched [(La/Yb)N=3.49]. LA-ICP-MS analyses of cpx show that a number of the studied spinel peridotite xenoliths experienced cryptic metasomatism. Three groups of xenoliths have been recognized according to their PM normalized REE and other incompatible trace element patterns in cpx: group I has depleted LREE abundances and group II is highly enriched in LREE (20-30 x PM) and group III has moderate LREE enrichments. Cores of some clinopyroxenes in group II have depleted LREE similar to those in group I, apparently representing relictic cores not affected by metasomatism. In addition, the metasomatized clinopyroxenes are significantly enriched in Sr, Th and U. Evidently, the metasomatic agent was a H2O-rich fluid (high LREE, Sr, Th and U). Mantle and cumulate dunites have experienced modal metasomatism. In both types of dunite interstitial clinopyroxene appear to be of metasomatic origin. The clinopyroxene from cumulate dunites depleted LREE abundances and low HREE indicating that they have been

  12. Expedition 6 Crew Interviews: Don Pettit, Flight Engineer 2/ International Space Station (ISS) Science Officer (SO)

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Expedition 6 member Don Pettit (Flight Engineer 2/ International Space Station (ISS) Science Officer (SO)) is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut and his career path. Pettit, who had been training as a backup crewmember, discusses the importance of training backups for ISS missions. He gives details on the goals and significance of the ISS, regarding experiments in various scientific disciplines such as the life sciences and physical sciences. Pettit also comments on the value of conducting experiments under microgravity. He also gives an overview of the ISS program to date, including the ongoing construction, international aspects, and the routines of ISS crewmembers who inhabit the station for four months at a time. He gives a cursory description of crew transfer procedures that will take place when STS-113 docks with ISS to drop off Pettit and the rest of Expedition 6, and retrieve the Expedition 5 crew.

  13. Specific features of organic matter in urban soils of Rostov-on-Don

    NASA Astrophysics Data System (ADS)

    Gorbov, S. N.; Bezuglova, O. S.

    2014-08-01

    Data on the fractional and group composition of humus in urban soils of Rostov-on-Don are discussed. We have compared the humus profiles of chernozems under tree plantations and those buried under anthropogenic deposits (including sealed chernozems under asphalt). It is shown that the type of humus in these soils remains stable despite a decrease in its total content after the long-term burial under asphalt. Under the impact of the trees, the organic matter of the chernozems acquired some features typical of gray forest soils, i.e., the humate-fulvate type of humus in the humus horizon and the sharp drop in the humus content down the soil profile.

  14. Don Juan-Fracture” as a Hint to Aortic Isthmus Rupture

    PubMed Central

    Suksompong, Sirilak; von Bormann, Benno

    2014-01-01

    We report a case of thoracic aortic rupture after blunt trauma in a 23-year-old male patient. The initial investigation found no external injury or bleeding, only a slightly widened mediastinum and a broken left calcaneus. Abdominal lavage was negative, biochemistry was normal, and breathing and oxygenation were not compromised. When changing his position during diagnostics, the patient all of a sudden developed cardiac arrest and typical signs of hypovolemic shock. An immediate sternotomy was done without any further diagnostics on suspicion of aortic isthmus injury. A circular avulsion at the ligamentum arteriosum was found as assumed and repaired under cardiopulmonary bypass. The patient left the hospital for rehabilitation after 12 days in adequate health status. Biodynamics of blunt trauma after high-speed frontal impact and the relationship between calcaneus fracture, called “Don-Juan fracture,” and aortic rupture at the site of ligamentum arteriosum are discussed. PMID:25478249

  15. STS-86 crew member Wolf dons a gas mask during TCDT

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-86 Mission Specialist David A. Wolf dons a gas mask as part of training exercises during the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. Wolf is wearing the patch from his first and only mission to date, STS-58 in 1993. STS-86 will be the seventh docking of the Space Shuttle with the Russian Space Station Mir. During the docking, Wolf will transfer to the orbiting Russian station and become a member of the Mir 24 crew, replacing U.S. astronaut C. Michael Foale, who has been on the Mir since the last docking mission, STS-84, in May. Launch of Mission STS-86 aboard the Space Shuttle Atlantis is targeted for Sept. 25.

  16. What We Don't Understand, We Explain to Each Other

    NASA Astrophysics Data System (ADS)

    Pines, David

    2015-12-01

    "What we don't understand, we explain to each other" was Robert Oppenheimer's 1948 description of theoretical physics as a profession. Because the phrase connects research, teaching, and learning, it seemed the right approach for the talk I gave to the AAPT on receiving the 2013 J.D. Jackson Award for Excellence in Graduate Teaching, on which the present article is based. In what follows I describe how my experiences as a student, researcher, and teacher combined to shape the way I learn and teach physics, from my own courses to inventing and editing Frontiers in Physics, reshaping Reviews of Modern Physics, and experimenting with different approaches to communicating key concepts in physics.

  17. The Secret List of Dos and Don'ts for Filmmaking

    NASA Astrophysics Data System (ADS)

    Kramer, N.

    2012-12-01

    Science is a massive black box to billions of people who walk the streets. However, the process of filmmaking can be equally as mystifying. As with the development of many scientific experiments, the process starts on a napkin at a restaurant…but then what? The road to scientific publication is propelled by a canonical list of several dos and don't that fit most situations. An equally useful list exists for up-and-coming producers. The list streamlines efforts, optimizes your use of the tools at your fingertips and enhances impact. Many fundamentals can be learned from books, but during this talk we will project and discuss several examples of best practices, from honing a story, to identifying audience appeal, filming, editing and the secrets of inexpensively acquiring expert help. Whether your goal is a two-minute webisode or a 90 minute documentary, these time-tested practices, with a little awareness, can give life to your films.;

  18. On Planetary Evolution and the Evolution of Planetary Science During the Career of Don Anderson

    NASA Astrophysics Data System (ADS)

    Solomon, S. C.

    2003-12-01

    The planets of our solar system have long been viewed by Don Anderson as laboratories for testing general aspects of planetary evolution and as points of comparison to the Earth. I was fortunate to have been a student 39 years ago in a course at Caltech that Don taught with Bob Kovach on the interiors of the Earth and the planets. At that time, Mariner 4 had not yet flown by Mars, the lunar Ranger program was still in progress, and it was permissible to entertain the hypothesis that all of the terrestrial planets were identical in bulk composition. In the last four decades spacecraft have visited every planet from Mercury to Neptune; samples from the Moon, Mars, asteroids, and comets reside in our laboratories; and more than 100 planets have been discovered orbiting other stars. More importantly, traditionally distinct fields have merged to the point where planetary scientists must be conversant with the findings and modes of thinking from astronomy and biology as well as the geosciences. A few examples illustrate this confluence. Theoretical models for the structure of the atmospheres of gas-giant planets led to the first astronomical detection of an extrasolar planetary atmosphere for the transiting planet HD209458b. Although the atmospheric models were based on those for solar-system gas giants, the 3.5-day orbital period means that this planet is 100 times closer to its star than Jupiter is to the Sun, its effective temperature is 1100 K, and the detected signature of the planetary atmosphere was absorption by neutral sodium. Sodium in Mercury's exosphere, detected astronomically from Earth, figures into the question of how the terrestrial planets came to have distinct bulk compositions. Hypotheses to account for Mercury's high uncompressed density, and by inference its high ratio of metal to silicate, range from chemical gradients in the early solar nebula to preferential removal of silicates from a differentiated protoplanet by nebular heating or giant impact

  19. ESPaDOnS; an exhelle spectro-polarimetric device for the observation of stars

    NASA Astrophysics Data System (ADS)

    Manset, Nadine; Donati, Jean-Francois

    2003-02-01

    ESPaDOnS is an ongoing project for a cross-dispersed echelle spectrograph/spectropolarimeter, for general community use at the Canada-France-Hawaii Telescope. This instrument will provide: (1) a complete optical spectrum from 370 to 1,000 nm in a single exposure, with a variable resolution between 50,000 and 75,000, (2) all polarization components of the stellar light, and (3) 20% peak total throughput. The wide spectral coverage will maximize the multiplex gain associated wtih multi-line techniques. The high resolution will give sufficient spatial resolution for Doppler and Zeeman-Doppler imaging of rapid rotators, increasing the sensitivity of the observations to small-scale structures. It will also allow accurate brightness, abundance and magnetic field mapping of moderate rotators, and help study stellar pulsations, abundances, and extrasolar planets. The possibility of recording two interleaved spectra will be very useful in polarimetric mode, and very convenient for faint object spectroscopy in non-polarimetric mode, where the spectrum of the adjacent sky will be recorded along with that of the target. The spectrographic is bench-mounted and fed by low-OH H-treated Ceram-Optec optical fibers from a Cassegran module containing all calibration and polarimetric facilities, making it possible to have extremely good wavelength stability and minimal instrumental polarization. The achromatic polarimeter includes one quarter-wave and two half-wave Fresnel rhombs coupled to a removable Wollaston prism. ESPaDOnS will be a unqiue instrument worldwide in polarimetric mode, competitive wiht similar instruments on 8-m class telescopes in non-polarimetric mode. Astronomers will be able to address with unprecedented details a broad range of important issues in stellar physics, circumstellar environments, and extrasolar planets.

  20. Size, Albedo, and Taxonomy of the Don Quijote Space Mission Target

    NASA Astrophysics Data System (ADS)

    Harris, Alan; Mueller, Michael; Fitzsimmons, Alan

    2006-03-01

    Rendezvous and lander missions are a very effective but very expensive way of investigating Solar-System bodies. The planning, optimization and success of space missions depends crucially on prior remotely-sensed knowledge of target bodies. Near-Earth asteroids (NEAs), which are mainly fragments of main-belt asteroids, are seen as important goals for investigation by space missions, mainly due to the role their forebears played in planet formation and the evolution of the Solar System, but also for the pragmatic reason that these objects can collide with the Earth with potentially devastating consequences. The European Space Agency is currently planning the Don Quijote mission to a NEA, which includes a rendezvous (and perhaps a lander) spacecraft and an impactor vehicle. The aim is to study the physical properties of the target asteroid and the effects of the impact on its dynamical state, as a first step in considering realistic mitigation measures against an eventual hazardous NEA. Two potential targets have been selected for the mission, the preferred one being (10302) 1989 ML, which is energetically easier to reach and is possibly a scientifically interesting primitive asteroid. However, due to the ambiguity of available spectral data, it is currently not possible to confidently determine the taxonomic type and mineralogy of this object. Crucially, the albedo is uncertain by a factor of 10, which leads to large uncertainties in the size and mass and hence the planned near-surface operations of Don Quijote. Thermal-infrared observations are urgently required for accurate size and albedo determination. These observations, which can only be carried out by Spitzer and would require only a modest amount of observing time, would enable an accurate diameter to be derived for the first time and the resulting albedo would remove the taxonomic ambiguity. The proposed Spitzer observations are critical for effective mission planning and would greatly increase our

  1. Initial Symptoms of ALS

    MedlinePlus

    ... Combine your passion and commitment to finding a cure for ALS while achieving physical challenges through athletic events Register ... - 1275 K Street NW - Suite 250 - Washington, DC 20005 All content and works posted on this website are owned ...

  2. Genetic Testing for ALS

    MedlinePlus

    ... Some medical centers may require a neurological exam, psychological assessment and counseling before predictive testing. If a person in the family with ALS has a negative genetic test result (no identified genetic mutation), testing family members ...

  3. Lou Gehrig's Disease (ALS)

    MedlinePlus

    ... when it becomes necessary. For instance, a power wheelchair can enable a paralyzed person with ALS to ... done these things despite being confined to a wheelchair for many years, being able to move only ...

  4. Rub al Khali, Arabia

    NASA Image and Video Library

    2008-08-08

    NASA Terra spacecraft shows the Rub al Khali, one of the largest sand deserts in the world, encompassing most of the southern third of the Arabian Peninsula; it includes parts of Oman, United Arab Emirates, and Yemen.

  5. Ag-Al-Ca

    NASA Astrophysics Data System (ADS)

    Carow-Watamura, U.; Louzguine, D. V.; Takeuchi, A.

    This document is part of Part 1 http://dx.doi.org/10.1007/97.etType="URL"/> 'Systems from Ag-Al-Ca to Au-Pd-Si' of Subvolume B 'Physical Properties of Ternary Amorphous Alloys' of Volume 37 'Phase Diagrams and Physical Properties of Nonequilibrium Alloys' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains the Chapter 'Ag-Al-Ca' with the content:

  6. Frequently Asked Questions about ALS and the ALS Registry

    MedlinePlus

    ... long do people with familial ALS live? Do clusters of ALS possibly exist? (I have been told ... related?) What are the problems with studying possible clusters of ALS? What are motor neuron (nerve cell) ...

  7. Effects of deoxynivalenol (DON) and its microbial biotransformation product deepoxy-deoxynivalenol (DOM-1) on a trout, pig, mouse, and human cell line.

    PubMed

    Mayer, Elisabeth; Novak, Barbara; Springler, Alexandra; Schwartz-Zimmermann, Heidi E; Nagl, Veronika; Reisinger, Nicole; Hessenberger, Sabine; Schatzmayr, Gerd

    2017-07-24

    Deoxynivalenol (DON), a trichothecene produced by various Fusarium species, is one of the most prevalent food- and feed-associated mycotoxins. The effects of DON and deepoxy-deoxynivalenol (DOM-1) were assessed in five different cell lines from different tissues and species starting from the first line of defense, the trout gill (RTgill-W1) and pig intestinal cells (IPEC-1 and IPEC-J2) over immune cells, as second line of defense (mouse macrophages RAW 264.7) to human liver cells (HepG2). Viability was assessed with a WST-1 assay, except for RTgill-W1, where a neutral red (NR) and sulforhodamine B (SRB) assay was performed. Additionally, more sensitive parameters, such as interleukin-, nitric oxide (NO)-, and albumin-release were determined. Viability was affected by DON at concentrations starting at 10 μmol/L (RTgill-W1), 0.9 μmol/L (IPEC-1), 3.5 μmol/L (IPEC-J2), and 0.9 μmol/L (HepG2), whereas DOM-1 did not have such an effect. Additionally, NO was decreased (0.84 μmol/L DON), whereas interleukin (IL)-6 was increased (0.42 μmol/L DON) in lipopolysaccharide (LPS)-stimulated DON-, but not DOM-1-treated RAW cells. Tumor necrosis factor (TNF)-α release, however, was not affected. Interestingly, albumin secretion of HepG2 cells was decreased by both DON and DOM-1 but at a much higher concentration for DOM-1 (228 versus 0.9 μmol/L for DON). 98.9% of DOM-1 was retrieved by liquid chromatography tandem mass spectrometry at the end of the experiment, proving its stability. In this study, IL-6 was the most sensitive parameter, followed by NO and albumin release and viability for HepG2 and IPEC-1.

  8. Epidemiology of ALS.

    PubMed

    Nelson, L M

    Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder of unknown etiology. ALS onset is rare before age 40 and increases with age thereafter. Men are at higher risk than women (ratio 1.3:1). Other than age and gender, the only indisputable risk factor for ALS is genetic susceptibility, with familial cases occurring in about 10% of most case series. Genetic linkage studies have provided evidence that a mutant form of the gene that codes for Cu/Zn superoxide dismutase, an endogenous free radical scavenger, is important in 15-20% of familial cases. Epidemiologic studies have identified associations of sporadic ALS with work in occupations that involve toxicant exposure. Environmental toxicants may act against a background of increased genetic susceptibility; however, genetically acquired biochemical defects have not been identified in sporadic ALS patients. Other epidemiologic theories of disease etiology have emphasized the potential role of physical trauma, electrical shock, and vigorous physical exertion, but evidence regarding these factors is inconsistent.

  9. Statins: Do They Cause ALS?

    MedlinePlus

    Statins: Do they cause ALS? Do statins cause amyotrophic lateral sclerosis (ALS)? Answers from Francisco Lopez-Jimenez, M.D. ... D. References Sorensen HT, et al. Statins and amyotrophic lateral sclerosis: The level of evidence for an association. Journal ...

  10. Photoelectron spectroscopy of the aluminum hydride anions: AlH2-, AlH3-, Al2H6-, Al3H9-, and Al4H12-

    NASA Astrophysics Data System (ADS)

    Zhang, Xinxing; Wang, Haopeng; Collins, Evan; Lim, Alane; Ganteför, Gerd; Kiran, Boggavarapu; Schnöckel, Hansgeorg; Eichhorn, Bryan; Bowen, Kit

    2013-03-01

    We report measurements of the negative ion photoelectron spectra of the simple aluminum hydride anions: AlH2-, AlH3-, Al2H6-, Al3H9-, and Al4H12-. From these spectra, we measured the vertical detachment energies of the anions, and we estimated the electron affinities of their neutral counterparts. Our results for AlH2-, AlH3-, and Al2H6- were also compared with previous predictions by theory.

  11. Photoelectron spectroscopy of the aluminum hydride anions: AlH2(-), AlH3(-), Al2H6(-), Al3H9(-), and Al4H12(-).

    PubMed

    Zhang, Xinxing; Wang, Haopeng; Collins, Evan; Lim, Alane; Ganteför, Gerd; Kiran, Boggavarapu; Schnöckel, Hansgeorg; Eichhorn, Bryan; Bowen, Kit

    2013-03-28

    We report measurements of the negative ion photoelectron spectra of the simple aluminum hydride anions: AlH2(-), AlH3(-), Al2H6(-), Al3H9(-), and Al4H12(-). From these spectra, we measured the vertical detachment energies of the anions, and we estimated the electron affinities of their neutral counterparts. Our results for AlH2(-), AlH3(-), and Al2H6(-) were also compared with previous predictions by theory.

  12. ALS superbend magnet system

    SciTech Connect

    Zbasnik, J.; Wang, S.T.; Chen, J.Y.; DeVries, G.J.; DeMarco, R.; Fahmie, M.; Geyer, A.; Green, M.A.; Harkins, J.; Henderson, T.; Hinkson, J.; Hoyer, E.H.; Krupnick, J.; Marks, S.; Ottens, F.; Paterson, J.A.; Pipersky, P.; Portmann, G.; Robin, D.A.; Schlueter, R.D.; Steier, C.; Taylor, C.E.; Wahrer, R.

    2000-09-15

    The Lawrence Berkeley National Laboratory is preparing to upgrade the Advanced Light Source (ALS) with three superconducting dipoles (Superbends). In this paper we present the final magnet system design which incorporates R&D test results and addresses the ALS operational concerns of alignment, availability, and economy. The design incorporates conduction-cooled Nb-Ti windings and HTS current leads, epoxy-glass suspension straps, and a Gifford-McMahon cryocooler to supply steady state refrigeration. We also present the current status of fabrication and testing.

  13. What is the Word at Logos College? Homosocial ritual or homosexual denial in Don Delillo's End Zone?

    PubMed

    Hardin, M

    2000-01-01

    "What Is the Word at Logos College? Homosocial Ritual or Homosexual Denial in Don Delillo's End Zone?" investigates the homoerotic desire that, despite being culturally repressed, periodically surfaces in foothall. Given the highly closeted nature of American foothall, it is necessary to look at the puns, allusions, and interactions between the players to see how Don DeLillo has created a text that subtly exposes the homoerotics of male sport. In order to strengthen the connection between homoeroticism and football, I will show how football's invention and organization in America coincides with the construction of the homosexual subject. Football and other arenas for male-male play become enforced at the same time as desire begins to express itself; thus, football is the logical place in America to look for unresolved (and resolved) male homosexuality, and DeLillo does this skillfully.

  14. Malaria and primary education in Mali: a longitudinal study in the village of Donéguébougou.

    PubMed

    Thuilliez, Josselin; Sissoko, Mahamadou S; Toure, Ousmane B; Kamate, Paul; Berthélemy, Jean-Claude; Doumbo, Ogobara K

    2010-07-01

    This article assesses the role of malaria and certain social determinants on primary education, especially on educational achievement in Donéguébougou, a small village in a malaria-endemic area near Bamako, Mali. Field data was collected by the authors between November 2007 and June 2008 on 227 schoolchildren living in Donéguébougou. Various malaria indicators and econometric models were used to explain the variation in cognitive abilities, teachers' evaluation scores, school progression and absences. Malaria is the primary cause of school absences. Fixed-effects estimates showed that asymptomatic malaria and the presence of falciparum malaria parasites had a direct correlation with educational achievement and cognitive performance. The evidence suggests that the correlation is causal.

  15. Mitigation-relevant science with Don Quijote - a European-led mission to a near-Earth asteroid

    NASA Astrophysics Data System (ADS)

    Harris, A. W.; Galvez, A.; Benz, W.; Fitzsimmons, A.; Green, S. F.; Michel, P.; Valsecchi, G.; Paetzold, M.; Haeusler, B.; Carnelli, I.

    The Don Quijote concept includes a rendezvous spacecraft and an impactor vehicle The main aim of the mission is to carry out an experiment to demonstrate the modification of a near-Earth asteroid s orbit in a controlled way as a first step in establishing mitigation measures against an eventual hazardous object In particular the spacecraft would study the physical properties of the target asteroid and the effects of a kinetic impact on its dynamical state It is also expected that some spacecraft resources will be available for more general solar-system science investigations The Don Quijote mission is currently at the phase-A stage during which a number of European consortia of industrial and scientific partners will study its technical feasibility and potential scientific return The basic mission concept current scientific issues and the possibilities for international participation in the mission will be discussed

  16. "Malaria and Primary education in Mali: a longitudinal study in the village of Donéguébougou."

    PubMed Central

    Sissoko, Mahamadou S; Toure, Ousmane B; Kamate, Paul; Berthelemy, Jean-Claude; Doumbo, Ogobara K

    2010-01-01

    This article assesses the role of malaria and certain social determinants on primary education, especially on educational achievement in Donéguébougou, a small village in a malaria-endemic area near Bamako, Mali. Field data was collected by the authors between November 2007 and June 2008 on 227 schoolchildren living in Donéguébougou. Various malaria indicators and econometric models were used to explain the variation in cognitive abilities, teachers' evaluation scores, school progression and absences. Malaria is the primary cause of school absences. Fixed effects estimates showed that asymptomatic malaria and the presence of falciparum malaria parasites had a direct correlation with educational achievement and cognitive performance. The evidence suggests that the correlation is causal. PMID:20413198

  17. [The routes of helminth egg appearance on the territory of recreational areas and sites of the lower Don River].

    PubMed

    Khromenkova, E P

    1993-01-01

    Sanitary and parasitologic problems of recreation use of water bodies and coast lines are still to be studied. The author has examined the routes of invasion at recreation areas by the lower Don river. The river bed depositions and water as well as coastline soil were found contaminated with helminthic eggs. These eggs were brought by sewage water, feces, and surface flow. Effective ecologically justified measures should be developed to prevent it.

  18. Preclinical Models for Skeletal Research: How Commonly Used Species Mimic (or Don't) Aspects of Human Bone.

    PubMed

    Allen, Matthew R

    2017-01-01

    Preclinical studies play an indispensable role in exploring the biological regulation of the musculoskeletal system. They are required in all drug development pipelines where both small and large animal models are needed to understand efficacy and side effects. This brief review highlights 4 aspects of human bone, longitudinal bone growth, intracortical remodeling, collagen/mineral interface, and age-related changes, and discusses how various animal models recapitulate (or don't) these aspects of human skeletal physiology.

  19. A substantial fraction of phytoplankton-derived DON is resistant to degradation by a metabolically versatile, widely distributed marine bacterium

    PubMed Central

    Kimmance, Susan; McCormack, Paul

    2017-01-01

    The capacity of bacteria for degrading dissolved organic nitrogen (DON) and remineralising ammonium is of importance for marine ecosystems, as nitrogen availability frequently limits productivity. Here, we assess the capacity of a widely distributed and metabolically versatile marine bacterium to degrade phytoplankton-derived dissolved organic carbon (DOC) and nitrogen. To achieve this, we lysed exponentially growing diatoms and used the derived dissolved organic matter (DOM) to support an axenic culture of Alteromonas sp.. Bacterial biomass (as particulate carbon and nitrogen) was monitored for 70 days while growth dynamics (cell count), DOM (DOC, DON) and dissolved nutrient concentrations were monitored for up to 208 days. Bacterial biomass increased rapidly within the first 7 days prior to a period of growth/death cycles potentially linked to rapid nutrient recycling. We found that ≈75% of the initial DOC and ≈35% of the initial DON were consumed by bacteria within 40 and 4 days respectively, leaving a significant fraction of DOM resilient to degradation by this bacterial species. The different rates and extents to which DOC and DON were accessed resulted in changes in DOM stoichiometry and the iterative relationship between DOM quality and bacterial growth over time influenced bacterial cell C:N molar ratio. C:N values increased to 10 during the growth phase before decreasing to values of ≈5, indicating a change from relative N-limitation/C-sufficiency to relative C-limitation/N-sufficiency. Consequently, despite its reported metabolic versatility, we demonstrate that Alteromonas sp. was unable to access all phytoplankton derived DOM and that a bacterial community is likely to be required. By making the relatively simple assumption that an experimentally derived fraction of DOM remains resilient to bacterial degradation, these experimental results were corroborated by numerical simulations using a previously published model describing the interaction

  20. Antioxidative and antiaging activities and component analysis of Lespedeza cuneata G. Don extracts fermented with Lactobacillus pentosus.

    PubMed

    Seong, Joon Seob; Xuan, Song Hua; Park, So Hyun; Lee, Keon Soo; Park, Young Min; Park, Soo Nam

    2017-09-15

    Lespedeza cuneata G. Don is a traditional herb that has been shown to associate with multiple biological activities. In this study, we investigated the antioxidative/antiaging activities and performed an active component analysis of the non-fermented and fermented (using Lactobacillus pentosus) extracts of Lespedeza cuneata G. Don. The antioxidative activities of the fermented extract were higher than those of non-fermented extracts. The elastase inhibitory activity, inhibitory effects on UV-induced MMP-1 expression, and ability to promote type I procollagen synthesis were investigated in Hs68 human fibroblasts cells. These tests also revealed that the fermented extract had increased antiaging activities compared with the non-fermented extract. A component analysis of the ethyl acetate fractions of non-fermented and fermented extracts was performed using TLC, HPLC, and LC/ESI-MS/MS to observe changes in the components before and after fermentation. Six components that were different before and after fermentation were investigated. It was thought that kaempferol and quercetin were converted from kaempferol glucosides and quercetin glucosides, respectively, via bioconversion with the fermentation strain. These results indicate that the fermented extract of L. cuneata G. Don has potential for use as a natural cosmetic material with antioxidant and antiaging effects.

  1. Transformation of DON in reclaimed water under solar light irradiation leads to decreased haloacetamide formation potential during chloramination.

    PubMed

    Du, Ye; Zhang, Xue; Li, Chao; Wu, Qian-Yuan; Huang, Huang; Hu, Hong-Ying

    2017-10-15

    Reclaimed water is usually stored in rivers or lakes before subsequent use. In storage ecosystems, the natural process of solar light irradiation plays a key role in water quality, altering disinfection byproduct formation potential in later use. This study investigated changes in haloacetamide formation potential (HAcAm FP) during subsequent chloramination when reclaimed water was exposed to solar light irradiation. Significant decreases in HAcAm FP were observed for the solar light irradiated reclaimed water, with reductions of 27%-69% for different haloacetamides. Moreover, transformation of dissolved organic nitrogen (DON) to inorganic nitrogen occurred during irradiation. The application of (15)N- labeled monochloramine indicated that the nitrogen source of the decreased HAcAms mainly originated from DON, rather than chloramine. Chloramination of the model compound l-asparagine after irradiation demonstrated that the decreased HAcAms could be attributed to the decrease in DON. After solar light irradiation, the brominated HAcAm FP in the presence of bromide was also reduced, while the bromine incorporation factor remained steady. Overall, this study revealed the contribution of natural processes in controlling HAcAm FP during subsequent chloramination, suggesting solar light irradiation is important to water purification during reclaimed water storage. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Systemic and local effects of the Fusarium toxin deoxynivalenol (DON) are not alleviated by dietary supplementation of humic substances (HS).

    PubMed

    Dänicke, Sven; Brosig, Bianca; Klunker, Leslie Raja; Kahlert, Stefan; Kluess, Jeannette; Döll, Susanne; Valenta, Hana; Rothkötter, Hermann-Josef

    2012-03-01

    The aim of this study was to examine the effects of a control diet (CON) or a Fusarium toxin contaminated diet (FUS) with and without HS (CON-HS and FUS-HS, respectively) on pigs during a 10-week growth trial starting at 35.1±3.2 kg live weight (n=12/group). Moreover, 2 additional choice feeding groups were included to test the ability of the pigs to differentiate between the CON and FUS diet. Feeding the FUS diets (∼3 mg DON/kg) did not depress feed intake irrespective of HS addition. However, the pigs of the choice feeding groups recognised the FUS diets and acquired an ability to avoid these diets. DON residues were detected exclusively in the blood of pigs exposed to the FUS diets (7-21 ng/mL) but their levels were not affected by HS, suggesting their inefficiency in preventing DON absorption. While zonula occludens-1 protein expression and villus height in jejunum and ileum were not compromised by FUS feeding, the jejunal crypts were significantly deepened at 31% compared to the CON group. These changes had no consequences for nutrient digestibility or LPS levels in systemic blood (0.02-0.08 EU/mL). As portal LPS levels were not measured, FUS effects on intestinal LPS translocation cannot be excluded.

  3. Al Shanker Remembers.

    ERIC Educational Resources Information Center

    American Educator, 2000

    2000-01-01

    In a 1996 interview shortly before his death, Al Shanker, longtime president of the American Federation of Teachers, discussed such topics as: his own educational experiences; how he learned about political fighting in the Boy Scouts; the appeal of socialism; multinational corporations and the nation state; teaching tough students; and John Dewey…

  4. Fosetyl-al

    Integrated Risk Information System (IRIS)

    Integrated Risk Information System ( IRIS ) Chemical Assessment Summary U.S . Environmental Protection Agency National Center for Environmental Assessment This IRIS Summary has been removed from the IRIS database and is available for historical reference purposes . ( July 2016 ) Fosetyl - al ; CASRN

  5. Lait humain provenant d’une banque de dons ou acheté en ligne?

    PubMed Central

    St-Onge, Maude; Chaudhry, Shahnaz; Koren, Gideon

    2015-01-01

    Résumé Question Une de mes patientes m’a demandé si elle pourrait se procurer du lait humain par Internet pour allaiter son nourrisson s’il le fallait. L’usage de lait humain provenant d’une banque de dons est-il plus sécuritaire que son achat en ligne? Réponse L’Organisation mondiale de la Santé et l’American Academy of Pediatrics recommandent d’utiliser des dons de lait humain comme choix à privilégier lorsque le lait maternel n’est pas disponible. Cependant, la Société canadienne de pédiatrie n’approuve pas le partage de lait humain non traité. Le lait humain entreposé dans les banques de lait diffère de celui qu’on peut se procurer par Internet en raison du processus rigoureux de sélection des donneuses, des fréquentes inspections de la qualité, des procédés de transport règlementés et du processus de pasteurisation conforme aux directives établies par l’Agence canadienne d’inspection des aliments. La plupart des échantillons achetés en ligne contiennent des bactéries à gram négatif ou comptent au total plus de 104 unités formant colonies de bactéries aérobiques par millilitre; ils renferment aussi en moyenne au décompte total plus de bactéries aérobiques, de bactéries à gram négatif, de coliformes et de Staphylococcus spp que les échantillons des banques de lait. La croissance de la plupart des espèces de bactéries est associée au nombre de jours en transit, ce qui porte à croire que les conditions de collecte, d’entreposage et de transport sont médiocres pour le lait acheté en ligne.

  6. Proton irradiation studies on Al and Al5083 alloy

    NASA Astrophysics Data System (ADS)

    Bhattacharyya, P.; Gayathri, N.; Bhattacharya, M.; Gupta, A. Dutta; Sarkar, Apu; Dhar, S.; Mitra, M. K.; Mukherjee, P.

    2017-10-01

    The change in the microstructural parameters and microhardness values in 6.5 MeV proton irradiated pure Al and Al5083 alloy samples have been evaluated using different model based techniques of X-ray diffraction Line Profile Analysis (XRD) and microindendation techniques. The detailed line profile analysis of the XRD data showed that the domain size increases and saturates with irradiation dose both in the case of Al and Al5083 alloy. The corresponding microstrain values did not show any change with irradiation dose in the case of the pure Al but showed an increase at higher irradiation doses in the case of Al5083 alloy. The microindendation results showed that unirradiated Al5083 alloy has higher hardness value compared to that of unirradiated pure Al. The hardness increased marginally with irradiation dose in the case of Al5083, whereas for pure Al, there was no significant change with dose.

  7. Obstacles au don bénévole de sang dans la population de Kisangani en République Démocratique du Congo

    PubMed Central

    Agasa, Salomon Batina; Likwela, Joris Losimba

    2014-01-01

    Introduction Plusieurs facteurs font obstacles au don de sang dans les pays en développement. La présente étude avait pour objectifs d'analyser les connaissances, attitudes et pratiques de la population de Kisangani relatives au don de sang et d'identifier les obstacles au don de sang afin de guider la planification des activités de promotion du don de sang. Méthodes L’ enquête a été réalisée du 4 février au 27 août 2008 sur un échantillon de 1067 sujets par entretien. Résultats Sur 1067 sujets interviewés, 1002 (93.9%) sujets ont accepté de répondre. La plupart de nos enquêtés (81.5%, n=1002) avait connaissance de la pratique du don bénévole de sang à Kisangani. Quoique la majorité des sujets approuvent la pratique du don de sang, 57.9% (n=416) parmi eux n'ont jamais fait un don de sang. La raison principale avancé par ceux qui n'ont jamais fait un don de sang était qu'ils n'avaient pas été sollicités tandis que 35% (n=144), quoique sollicités, avaient refusés de faire un don de sang pour diverses raisons. Conclusion Cette enquête met en lumière le fait qu'il y a maintenant dans la population de Kisangani une attitude favorable au don de sang. Mais plusieurs obstacles empêchent encore le passage à l'acte. Des activités de promotion qui s'appuient sur la communication interpersonnelle devraient être mises sur pieds afin de passer des messages personnalisés aux donneurs potentiels de sang. PMID:25328602

  8. Effects of deoxynivalenol (DON), zearalenone (ZEN), and related metabolites on equine peripheral blood mononuclear cells (PBMC) in vitro and background occurrence of these toxins in horses.

    PubMed

    Schumann, Barbara; Winkler, Janine; Mickenautsch, Nicola; Warnken, Tobias; Dänicke, Sven

    2016-08-01

    Both deoxynivalenol (DON), zearalenone (ZEN), and their metabolites are known to modulate immune cells in various species whereby viability and proliferation are influenced. Such effects were rarely examined in horses. Therefore, one aim of the present study was to titrate the inhibitory concentrations of DON, 3-acetyl-DON (3AcDON), de-epoxy-DON (DOM-1), ZEN, and α- and β-zearalenol (ZEL) at which viability and proliferation of equine PBMC were reduced by 50 % (IC50) and 10 % (IC10) in vitro. For evaluation of practical relevance of the in vitro findings, a further aim was to screen horses for the background occurrence of DON, ZEN, and their metabolites in systemic circulation and to relate toxin residues both to the inhibitory toxin concentrations and to hematological and clinical-chemical characteristics.The IC50 (μM) for DON, 3AcDON, β-ZEL, α-ZEL, and ZEN were determined at 3.09, 25.90, 75.44, 97.44, and 98.15 in unstimulated cells, respectively, while in proliferating cells, the corresponding IC50 values were 0.73, 6.89, 45.16, 75.96, and 82.51. Neither viability nor proliferation was influenced by DOM-1 up to a concentration of 100 μM.The in vivo screening (N = 49) revealed the occurrence of ZEN (N = 24), α-ZEL (N = 3), β-ZEL (N = 37), DON, and DOM-1 (N = 2). The detected concentrations were much lower than the corresponding IC50 while the IC10 of DON and β-ZEL for proliferating PBMC corresponded to approximately 26 and 35 ng/mL which might be relevant when contaminated diets are fed.Clinical-chemical and hematological traits were not related to mycotoxin residue levels excepting blood urea nitrogen which was positively correlated to the sum of β-ZEL, α-ZEL, and ZEN concentration. Whether this reflects simply the feeding history of the horses or renal failures giving rise to a prolonged half-life of the toxins needs to be clarified further.

  9. Al Sumelat Water Network. Village of Al Sumelat, Iraq

    DTIC Science & Technology

    2006-03-15

    OFFICE OF THE SPECIAL INSPECTOR GENERAL FOR IRAQ RECONSTRUCTION AL SUMELAT WATER NETWORK VILLAGE OF AL SUMELAT, IRAQ...Sumelat Water Network Village of Al Sumelat, Iraq 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e...Al Sumelat Water Network Village of Al Sumelat, Iraq Synopsis Introduction. This report was previously provided on a limited distribution basis

  10. Mass sensing AlN sensors for waste water monitoring

    NASA Astrophysics Data System (ADS)

    Porrazzo, R.; Potter, G.; Lydecker, L.; Foraida, Z.; Gattu, S.; Tokranova, N.; Castracane, J.

    2014-08-01

    Monitoring the presence of nanomaterials in waste water from semiconductor facilities is a critical task for public health organizations. Advanced semiconductor technology allows the fabrication of sensitive piezoelectric-based mass sensors with a detection limit of less than 1.35 ng/cm2 of nanomaterials such as nanoparticles of alumina, amorphous silica, ceria, etc. The interactions between acoustic waves generated by the piezoelectric sensor and nanomaterial mass attached to its surface define the sensing response as a shift in the resonant frequency. In this article the development and characterization of a prototype AlN film bulk acoustic resonator (FBAR) are presented. DC reactive magnetron sputtering was used to create tilted c-axis oriented AlN films to generate shear waves which don't propagate in liquids thus minimizing the acoustic losses. The high acoustic velocity of AlN over quartz allows an increase in resonance frequency in comparison with a quartz crystal microbalance (QCM) and results in a higher frequency shift per mass change, and thus greater sensitivity. The membrane and electrodes were fabricated using state of the art semiconductor technology. The device surface functionalization was performed to demonstrate selectivity towards a specific nanomaterial. As a result, the devices were covered with a "docking" layer that allows the nanomaterials to be selectively attached to the surface. This was achieved using covalent modification of the surface, specifically targeting ZnO nanoparticles. Our functionalization approach was tested using two different types of nanoparticles, and binding specificity was confirmed with various analytical techniques.

  11. Vocal learning, prosody, and basal ganglia: don't underestimate their complexity.

    PubMed

    Ravignani, Andrea; Martins, Mauricio; Fitch, W Tecumseh

    2014-12-01

    Ackermann et al.'s arguments in the target article need sharpening and rethinking at both mechanistic and evolutionary levels. First, the authors' evolutionary arguments are inconsistent with recent evidence concerning nonhuman animal rhythmic abilities. Second, prosodic intonation conveys much more complex linguistic information than mere emotional expression. Finally, human adults' basal ganglia have a considerably wider role in speech modulation than Ackermann et al. surmise.

  12. Synthesis of silver nanoparticles using leaves of Catharanthus roseus Linn. G. Don and their antiplasmodial activities

    PubMed Central

    Ponarulselvam, S; Panneerselvam, C; Murugan, K; Aarthi, N; Kalimuthu, K; Thangamani, S

    2012-01-01

    Objective To develop a novel approach for the green synthesis of silver nanoparticles using aqueous leaves extracts of Catharanthus roseus (C. roseus) Linn. G. Don which has been proven active against malaria parasite Plasmodium falciparum (P. falciparum). Methods Characterizations were determined by using ultraviolet-visible (UV-Vis) spectrophotometry, scanning electron microscopy (SEM), energy dispersive X-ray and X-ray diffraction. Results SEM showed the formation of silver nanoparticles with an average size of 35–55 nm. X-ray diffraction analysis showed that the particles were crystalline in nature with face centred cubic structure of the bulk silver with the broad peaks at 32.4, 46.4 and 28.0. Conclusions It can be concluded that the leaves of C. roseus can be good source for synthesis of silver nanoparticle which shows antiplasmodial activity against P. falciparum. The important outcome of the study will be the development of value added products from medicinal plants C. roseus for biomedical and nanotechnology based industries. PMID:23569974

  13. Don/Doff support stand for use with rear entry space suits

    NASA Technical Reports Server (NTRS)

    Kosmo, Joseph J. (Inventor); Tri, Terry O. (Inventor); Spenny, William E. (Inventor); West, Philip R. (Inventor)

    1989-01-01

    A don/doff support stand for use with rear entry space suits is disclosed. The support stand is designed for use in one-g environments; however, certain features of the stand can be used on future space-craft, lunar or planetary bases. The present invention has a retainer which receives a protruding lug fixed on the torso section of the space suit. When the lug is locked in the retainer, the space suit is held in a generally upright position. In a one-g environment a portable ladder is positioned adjacent to the rear entry of the space suit supported by the stand. The astronaut climbs up the ladder and grasps a hand bar assembly positioned above the rear entry. The astronaut then slips his legs through the open rear entry and down into the abdominal portion of the suit. The astronaut then lowers himself fully into the suit. The portable ladder is then removed and the astronaut can close the rear entry door. The lug is then disengaged from the retainer and the astronaut is free to engage in training exercises in the suit. When suit use is over, the astronaut returns to the stand and inserts the lug into the retainer. A technician repositions the ladder. The astronaut opens the rear entry door, grasps the hand bar assembly and does a chin-up to extricate himself from the suit. The astronaut climbs down the movable ladder while the suit is supported by the stand.

  14. Don/doff support stand for use with rear entry space suits

    NASA Technical Reports Server (NTRS)

    Kosmo, Joseph J. (Inventor); Tri, Terry O. (Inventor); Spenny, William E. (Inventor); West, Philip R. (Inventor)

    1988-01-01

    A don/doff support stand for use with rear entry space suits is disclosed. The support stand is designed for use in one-g environments; however, certain features of the stand can be used on future spacecraft, lunar, or planetary bases. The present invention has a retainer which receives a protrucing lug fixed on the torso section of the space suit. When the lug is locked in the retainer, the space suit is held in a generally upright position. In a one-g environment a portable ladder is positioned adjacent to the rear entry of the space suit supported by the stand. The astronaut climbs up the ladder and grasps a hand bar assembly positioned above the rear entry. The astronaut then slips his legs through the open rear entry and down into the abdominal portion of the suite. The astronaut then lowers himself fully into the suit. The portable ladder is then removed and the astronaut can close the rear entry door. The lug is then disengaged from the retainer and the astronaut is free to engage in training exercises in the suit. When suit use is over, the astronaut returns to the stand and inserts the lug into the retainer. A technician repositions the ladder. The astronaut opens the rear entry door, grasps the hand bar assembly and does a chin-up to extricate himself from the suit. The astronaut climbs down the movable ladder while the suit is supported by the stand.

  15. What consumers don't know about genetically modified food, and how that affects beliefs.

    PubMed

    McFadden, Brandon R; Lusk, Jayson L

    2016-09-01

    In the debates surrounding biotechnology and genetically modified (GM) food, data from consumer polls are often presented as evidence for precaution and labeling. But how much do consumers actually know about the issue? New data collected from a nationwide U.S. survey reveal low levels of knowledge and numerous misperceptions about GM food. Nearly equal numbers of consumers prefer mandatory labeling of foods containing DNA as do those preferring mandatory labeling of GM foods. When given the option, the majority of consumers prefer that decisions about GM food be taken out of their hands and be made by experts. After answering a list of questions testing objective knowledge of GM food, subjective, self-reported knowledge declines somewhat, and beliefs about GM food safety increase slightly. Results suggest that consumers think they know more than they actually do about GM food, and queries about GM facts cause respondents to reassess how much they know. The findings question the usefulness of results from opinion polls as a motivation for creating public policy surrounding GM food.-McFadden, B. R., Lusk, J. L. What consumers don't know about genetically modified food, and how that affects beliefs.

  16. Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae).

    PubMed

    Tiong, Soon Huat; Looi, Chung Yeng; Arya, Aditya; Wong, Won Fen; Hazni, Hazrina; Mustafa, Mohd Rais; Awang, Khalijah

    2015-04-01

    Vindogentianine, a new indole alkaloid together with six known alkaloids, vindoline, vindolidine, vindolicine, vindolinine, perivine and serpentine were isolated from leaf extract (DA) of Catharanthus roseus (L.) G. Don. Their structures were elucidated by spectroscopic methods; NMR, MS, UV and IR. Vindogentianine is a dimer containing a vindoline moiety coupled to a gentianine moiety. After 24h incubation, vindogentianine exhibited no cytotoxic effect in C2C12 mouse myoblast and β-TC6 mouse pancreatic cells (IC50>50μg/mL). Real-time cell proliferation monitoring also indicated vindogentianine had little or no effect on C2C12 mouse myoblast cell growth at the highest dose tested (200μg/mL), without inducing cell death. Vindogentianine exhibited potential hypoglycemic activity in β-TC6 and C2C12 cells by inducing higher glucose uptake and significant in vitro PTP-1B inhibition. However, in vitro α-amylase and α-glucosidase inhibition assay showed low inhibition under treatment of vindogentianine. This suggests that hypoglycemic activity of vindogentianine may be due to the enhancement of glucose uptake and PTP-1B inhibition, implying its therapeutic potential against type 2 diabetes.

  17. Nuclear power plant transient diagnostics using artificial neural networks that allow ``don`t-know`` classifications

    SciTech Connect

    Bartal, Y.; Lin, J.; Uhrig, R.E.

    1995-06-01

    A nuclear power plant`s (NPP`s) status is usually monitored by a human operator. Any classifier system used to enhance the operator`s capability to diagnose a safety-critical system like an NPP should classify a novel transient as ``don`t-know`` if it is not contained within its accumulated knowledge base. In particular, the classifier needs some kind of proximity measure between the new data and its training set. Artificial neural networks have been proposed as NPP classifiers, the most popular ones being the multilayered perceptron (MLP) type. However, MLPs do not have a proximity measure, while learning vector quantization, probabilistic neural networks (PNNs), and some others do. This proximity measure may also serve as an explanation to the classifier`s decision in the way that case-based-reasoning expert systems do. The capability of a PNN network as a classifier is demonstrated using simulator data for the three-loop 436-MW(electric) Westinghouse San Onofre unit 1 pressurized water reactor. A transient`s classification history is used in an ``evidence accumulation`` technique to enhance a classifier`s accuracy as well as its consistency.

  18. Promising anticancer activities of Justicia simplex D. Don. in cellular and animal models.

    PubMed

    Joseph, Litty; Aranjani, Jesil Mathew; Pai, K Sreedhara Ranganath; Srinivasan, K K

    2017-03-06

    Justicia simplex D. Don. belonging to the family of Acanthaceae has been traditionally used for treatment of rheumatism, inflammation and bronchitis. The plant is traditionally considered as an anticancer medicine and is used by healers of Karnataka to treat various types of cancers. The present study aims at the elucidation of anticancer activity of various extracts of J. simplex, isolation of its active constituents and assessment of the role in growth inhibition and angiogenesis both in vitro and in vivo. Extracts of J. simplex was evaluated for the in vitro cytotoxic effect by Brine Shrimp Lethality assay, Trypan Blue dye exclusion assay and antiproliferative assay. In vivo cytotoxicity of the extracts were determined by liquid tumor model in Swiss albino mice. Tumor prognosis, metastasis and angiogenesis were assessed by VEGF expression of the solid tumor. Phytochemical analysis afforded the isolation of a compound, the chemical structure of which was established using IR, NMR and TOF-MS spectral method. The compound was also evaluated for the growth inhibitory and angiogenic effects. The petroleum ether extract revealed potent anticancer activity in in vitro and in vivo studies. The anti-angiogenic effect is due to the down regulation of VEGF expression. The growth inhibitory assay revealed that the isolated compound namely triacontanoic ester of 5''-hydroxyjustisolin is responsible for the anticancer activity. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  19. Mutagenicity and antimutagenicity of Salacia crassifolia (mart. Ex. Schult.) G. Don. evaluated by Ames test.

    PubMed

    Carneiro, C C; Véras, J Holanda; Góes, B R Lima; Pérez, C N; Chen-Chen, L

    2017-09-21

    Salacia crassifolia (Mart. Ex. Schult.) G. Don. is a bush which belongs to Celastraceae family and occurs specially in Brazilian Cerrado. Its leaves, stem, seeds and fruits are popularly used for several medicinal purposes, such as antitumoral, antirheumatic, anti-inflammatory and antimicrobial. In this study, the mutagenic and antimutagenic activities of S. crassifolia stem bark fractions (hexane, ethyl acetate and hydroalcoholic) were evaluated by the Ames mutagenicity assay in Salmonella typhimurium TA98 and TA100 strains. By the obtained results, all S. crassifolia fractions did not significantly increase the number of prototrophic revertants for histidine (His+) in both S. typhimurium strains tested (p > 0.05), suggesting absence of mutagenicity. Regarding antimutagenicity, the fractions ethyl acetate and hydroalcoholic significantly decreased the number of His+ revertants colonies induced by positive control for strain TA98 (p < 0.05), demonstrating protection against mutagenicity induced by 4-nitroquinolile1-oxide, whereas the hexane fraction did not show antimutagenic effect in this strain. In the TA100 strain, all fractions of S. crassifolia protected DNA against the harmful action of sodium azide, and the hexane fraction exhibited the greatest protection in this work. Thus, it's possible conclude that the fractions of S. crassifolia tested in this study could be used in chemoprevention.

  20. Cadmium accumulation characteristics of the winter farmland weeds Cardamine hirsuta Linn. and Gnaphalium affine D. Don.

    PubMed

    Lin, Lijin; Shi, Jun; Liu, Qihua; Liao, Ming'an; Mei, Luoyin

    2014-07-01

    In a preliminary study, we found that the cadmium (Cd) concentrations in shoots of the winter farmland weeds Cardamine hirsuta Linn. and Gnaphalium affine D. Don exceeded the critical value of a Cd-hyperaccumulator (100 mg kg(-1)), indicating that these two farmland weeds might be Cd-hyperaccumulators. In this study, we grew these species in soil containing various concentrations of Cd to further evaluate their Cd accumulation characteristics. The biomasses of C. hirsuta and G. affine decreased with increasing Cd concentrations in the soil, while the root/shoot ratio and the Cd concentrations in shoot tissues increased. The Cd concentrations in shoots of C. hirsuta and G. affine reached 121.96 and 143.91 mg kg(-1), respectively, at the soil Cd concentration of 50 mg kg(-1). Both of these concentrations exceeded the critical value of a Cd-hyperaccumulator (100 mg kg(-1)). The shoot bioconcentration factors of C. hirsuta and G. affine were greater than 1. The translocation factor of C. hirsuta was less than 1 and that of G. affine was greater than 1. These findings indicated that C. hirsuta is a Cd-accumulator and G. affine is Cd-hyperaccumulator. Both plants are distributed widely in the field, and they could be used to remediate Cd-contaminated farmland soil in winter.

  1. Clones identification of Sequoia sempervirens (D. Don) Endl. in Chile by using PCR-RAPDs technique*

    PubMed Central

    Toral Ibañez, Manuel; Caru, Margarita; Herrera, Miguel A.; Gonzalez, Luis; Martin, Luis M.; Miranda, Jorge; Navarro-Cerrillo, Rafael M.

    2009-01-01

    A protocol of polymerase chain reaction-random amplified polymorphic DNAs (PCR-RAPDs) was established to analyse the gene diversity and genotype identification for clones of Sequoia sempervirens (D. Don) Endl. in Chile. Ten (out of 34) clones from introduction trial located in Voipir-Villarrica, Chile, were studied. The PCR-RAPDs technique and a modified hexadecyltrimethylammonium bromide (CTAB) protocol were used for genomic DNA extraction. The PCR tests were carried out employing 10-mer random primers. The amplification products were detected by electrophoresis in agarose gels. Forty nine polymorphic bands were obtained with the selected primers (BG04, BF07, BF12, BF13, and BF14) and were ordered according to their molecular size. The genetic similarity between samples was calculated by the Jaccard index and a dendrogram was constructed using a cluster analysis of unweighted pair group method using arithmetic averages (UPGMA). Of the primers tested, 5 (out of 60) RAPD primers were selected for their reproducibility and high polymorphism. A total of 49 polymorphic RAPD bands were detected out of 252 bands. The genetic similarity analysis demonstrates an extensive genetic variability between the tested clones and the dendrogram depicts the genetic relationships among the clones, suggesting a geographic relationship. The results indicate that the RAPD markers permitted the identification of the assayed clones, although they are derived from the same geographic origin. PMID:19235269

  2. Clones identification of Sequoia sempervirens (D. Don) Endl. in Chile by using PCR-RAPDs technique.

    PubMed

    Toral Ibañez, Manuel; Caru, Margarita; Herrera, Miguel A; Gonzalez, Luis; Martin, Luis M; Miranda, Jorge; Navarro-Cerrillo, Rafael M

    2009-02-01

    A protocol of polymerase chain reaction-random amplified polymorphic DNAs (PCR-RAPDs) was established to analyse the gene diversity and genotype identification for clones of Sequoia sempervirens (D. Don) Endl. in Chile. Ten (out of 34) clones from introduction trial located in Voipir-Villarrica, Chile, were studied. The PCR-RAPDs technique and a modified hexadecyltrimethylammonium bromide (CTAB) protocol were used for genomic DNA extraction. The PCR tests were carried out employing 10-mer random primers. The amplification products were detected by electrophoresis in agarose gels. Forty nine polymorphic bands were obtained with the selected primers (BG04, BF07, BF12, BF13, and BF14) and were ordered according to their molecular size. The genetic similarity between samples was calculated by the Jaccard index and a dendrogram was constructed using a cluster analysis of unweighted pair group method using arithmetic averages (UPGMA). Of the primers tested, 5 (out of 60) RAPD primers were selected for their reproducibility and high polymorphism. A total of 49 polymorphic RAPD bands were detected out of 252 bands. The genetic similarity analysis demonstrates an extensive genetic variability between the tested clones and the dendrogram depicts the genetic relationships among the clones, suggesting a geographic relationship. The results indicate that the RAPD markers permitted the identification of the assayed clones, although they are derived from the same geographic origin.

  3. Shoot regeneration and somatic embryogenesis from needles of redwood (Sequoia sempervirens (D.Don.) Endl.).

    PubMed

    Liu, Cuiqiong; Xia, Xinli; Yin, Weilun; Huang, Lichun; Zhou, Jianghong

    2006-07-01

    A rapid and effective system of somatic embryogenesis and organogenesis from the in vitro needles of redwood (Sequoia sempervirens (D.Don.) Endl.) had been established. The influences of plant growth regulators (PGRs) and days of seedlings in vitro on adventitious bud regeneration and somatic embryogenesis were studied. The process of somatic embryo formation was also observed. The results showed that embryogenic callus was induced and proliferated on Schenk and Hildebrandt (SH) medium with BA (0.5 mg/l), KT (0.5 mg/l) and IBA (1.0 mg/l). SH medium containing BA (0.5 mg/l), KT (0.2 mg/l) and IBA (0.2 mg/l) effectively promoted adventitious bud regeneration. The highest frequency (66.3%) of direct somatic embryogenesis was obtained in the combination of BA (0.5 mg/l) and IBA (0.5 mg/l). The optimal days of seedling in vitro for adventitious bud and somatic embryogenesis were 30 days and 30-40 days, respectively. The developments of somatic embryos were similar to that of zygotic embryogenesis. The result of histocytological studies indicated that proteins were gradually accumulated in the process of somatic embryo formation and there were two peaks of starch grains accumulation that one was in the embryogenic callus and the other was in the globular embryos. These results indicated that starch and protein were closely related with the energy supply and the molecular base of somatic embryogenesis, respectively.

  4. Dos and don'ts for using climate information for water resource planning and management

    NASA Astrophysics Data System (ADS)

    Vano, J. A.; Clark, M. P.; Nijssen, B.; Wood, A.; Gutmann, E. D.; Arnold, J.

    2016-12-01

    Increasingly water managers and planners are being required to incorporate climate change information into their planning processes. This is generally seen as a step in the right direction. However, the continuously evolving and expanding realm of climate information can be confusing to use and easy to apply in ways the information producers never intended, and often in ways those producers might say are not viable. Additionally, advice on how various products should be used is not usually straightforward - it may require an extended dialogue between scientists and end users, which is not always feasible with current resources. While rarely is there a one-size fits all approach, there are usually preferable paths forward. To help the water resource planning and management community navigate the ever-changing climate science landscape, we present a set of guidelines for better practices when using climate information. These are divided into two categories: (1) process-based recommendations for developing an effective approach for using climate change scenarios, and (2) product-based cautions for using climate change information. This collection of dos and don'ts provides context on why certain strategies are preferable, including real-world examples. This work is intended to provide a foundation that can be built on through dialogue within and between the climate science and application communities to increase the usefulness of climate information.

  5. An extraterrestrial habitat on Earth: the algal mat of Don Juan [correction of Jaun] Pond.

    PubMed

    Siegel, B Z; Siegel, S M; Chen, J; LaRock, P

    1983-01-01

    On the edge of Don Juan Pond in the Wright Valley of Antarctica lies a mat of mineral and detritus cemented by organic matter. In spite of a CaCl2 concentration of about 33% (w/v), the mat contains Oscillatoria and other cyanobacteria, unicellular forms, colonial forms rich in carotenoids, and diatoms. Bacteria are rare; fungal filaments are not. Oscillatoria showed motility but only at temperatures <10 degrees C. Acetone extracts of the mat and nearby muds yielded visible spectra similar to those of laboratory grown O. sancta, with 50- to 70-fold molar ratio of chlorophyll a to b. Although rare, tardigrades were also found. The algal mat had enzymatic activities characteristic of peroxidase, catalase, dehydrogenase, and amylase. Cellulose, chitin, protein, lipid and ATP were present. Previously, algae in the Wright Valley have been described in melt water, not in the brine itself. Wright Valley has been used as a near sterile Martian model. It obviously contains an array of hardy terrestrial organisms.

  6. E-mail netiquette for the medical practice employee: 50 do's and don'ts.

    PubMed

    Hills, Laura

    2011-01-01

    E-mail has at one and the same time become a primary communication tool for many medical practice employees and a source of untold frustration, misunderstandings, and stress. This article provides a total of 50 rules (25 do's and 25 don'ts) for e-mail netiquette to help medical practice employees use e-mail more effectively. It offers suggestions about the optimal format of e-mails, tips for writing concise e-mail texts, and guidance about the most pressing e-mail privacy and confidentiality concerns. Medical practice employees can use the practical tips presented in this article to help them save time and use their medical practices' e-mail system more productively and effectively. This article also offers suggestions for creating and using a medical practice e-mail disclaimer statement. It describes the six legal threats a disclaimer statement can prevent and the typical content for such disclaimers. Finally, this article includes guidance about creating and implementing a medical practice e-mail policy and provides an outline of typical e-mail policy content.

  7. Triterpenoids with acetylcholinesterase inhibition from Chuquiraga erinacea D. Don. subsp. erinacea (Asteraceae).

    PubMed

    Gurovic, María Soledad; Castro, María Julia; Richmond, Victoria; Faraoni, María Belén; Maier, Marta S; Murray, Ana Paula

    2010-04-01

    A bioactivity-guided approach was taken to identify the acetylcholinesterase (AChE) inhibitory agents in the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves using a bioautographic method. This permitted the isolation of the pentacyclic triterpenes calenduladiol (1), faradiol (2), heliantriol B2 (3), lupeol (4), and a mixture of alpha-and beta-amyrin ( 5A and 5B) as active constituents. Pseudotaraxasterol (6) and taraxasterol (7) were also isolated from this extract and showed no activity at the same analytical conditions. Compound 1 showed the highest AChE inhibitory activity with 31.2 % of inhibition at 0.5 mM. Looking forward to improve the water solubility of the active compounds, the sodium sulfate ester of 1 was prepared by reaction with the (CH3)3N.SO3 complex. The semisynthetic derivative disodium calenduladiol disulfate (8) elicited higher AChE inhibition than 1 with 94.1 % of inhibition at 0.5 mM (IC (50) = 0.190 +/- 0.003 mM). Compounds 1, 2, 3, 5, 6, and 7 are reported here for the first time in C. erinacea. This is the first report of AChE inhibition from calenduladiol (1) as well as from a sulfate derived from a natural product.

  8. 'Hey everybody, don't get pregnant': Zika, WHO and an ethical framework for advising.

    PubMed

    Byron, Katie; Howard, Dana

    2016-12-05

    WHO recently issued new guidance on the prevention of sexual transmission of Zika virus. The updated guidance states that '[c]ountry health programmes should ensure that… [i]n order to prevent adverse pregnancy and fetal outcomes, men and women of reproductive age, living in areas where local transmission of Zika virus is known to occur, be correctly informed and oriented to consider delaying pregnancy'. While the media has reported this advice as WHO telling couples in Zika-affected regions to avoid pregnancy, WHO states that they are not doing that. In an interview with the New York Times, a spokesperson from WHO stated, 'it's important to understand that this is not WHO saying, "Hey everybody, don't get pregnant." It's that they should be advised about this, so they themselves can make the final decision'. In this statement, the WHO's spokesperson distinguishes between actively directing individuals to delay pregnancy and advising them, which is portrayed as a merely informative act that facilitates but does not direct an individual's final decision. This paper proposes that advising should not be understood as a purely informational and non-directive act. The choices that agencies make in what advice to offer and to whom to offer the advice are ethical choices with practical implications. We will thus lay out a framework for considering the ethical issues that arise in the context of advising and demonstrate how it can be used to evaluate the WHO guidance.

  9. DOC and DON Dynamics along the Bagmati Drainage Network in Kathmandu Valley

    NASA Astrophysics Data System (ADS)

    Bhatt, M. P.; McDowell, W. H.

    2005-05-01

    We studied organic matter dynamics and inorganic chemistry of the Bagmati River in Kathmandu valley, Nepal, to understand the influence of human and geochemical processes on chemical loads along the drainage system. Population density appears to be the most fundamental control on the chemistry of surface waters within the Bagmati drainage system. DOC concentration increases 10-fold with distance downstream (from 2.38 to 23.95 mg/L) and shows a strong relationship with human population density. The composition of river water (nutrients, Cl) suggests that sewage effluent to the river has a major effect on water quality. Concentrations were highest during summer, and lowest during the winter monsoon season. In contrast to DOC, DON concentration shows surprisingly little variation, and tends to decrease in concentration with distance downstream. Ammonium contributes almost all nitrogen in the total dissolved nitrogen fraction and the concentration of nitrate is negligible, probably due to rapid denitrification within the stream channel under relatively low-oxygen conditions. Decreases in sulfate along the stream channel may also be due to the reduction of sulfate to sulfide due to the heavy organic matter loading. Water quality is unacceptable for any use and the whole ecosystem is severely affected within the urban areas. Based on a comparison of downstream and upstream water quality, it appears that human activities along the Bagmati, principally inputs of human sewage, are largely responsible for the changes in surface water chemistry within Kathmandu valley.

  10. An extraterrestrial habitat on earth: The algal mat of Don Jaun Pond

    NASA Astrophysics Data System (ADS)

    Siegel, B. Z.; Siegel, S. M.; Chen, J.; Larock, P.

    On the edge of Don Juan Pond in the Wright Valley of Antarctica lies a mat of mineral and detritus cemented by organic matter. In spite of a CaCl2 concentration of about 33% (w/v), the mat contains Oscillatoria and other cyanobacteria, unicellular forms, colonial forms rich in carotenoids, and diatoms. Bacteria are rare; fungal filaments are not. Oscillatoria showed motility, but only at temperatures <10°C. Acetone extracts of the mat and nearby muds yielded visible spectra similar to those of laboratory grown O. sancta, with 50- to 70-fold molar ratio of chlorophyll a to b. Although rare, tardigrades were also found. The algal mat had enzymatic activities characteristic of peroxidase, catalase, dehydrogenase, and amylase. Cellulose, chitin, protein, lipid and ATP were present. Previously, algae in the Wright Valley have been described in melt water, not in the brine itself. Wright Valley has been used as a near sterile Martian model. It obviously contains an array of hardy terrestrial organisms.

  11. Proteomic profiling of proteins associated with the rejuvenation of Sequoia sempervirens (D. Don) Endl

    PubMed Central

    2010-01-01

    Background Restoration of rooting competence is important for rejuvenation in Sequoia sempervirens (D. Don) Endl and is achieved by repeatedly grafting Sequoia shoots after 16 and 30 years of cultivation in vitro. Results Mass spectrometry-based proteomic analysis revealed three proteins that differentially accumulated in different rejuvenation stages, including oxygen-evolving enhancer protein 2 (OEE2), glycine-rich RNA-binding protein (RNP), and a thaumatin-like protein. OEE2 was found to be phosphorylated and a phosphopeptide (YEDNFDGNSNVSVMVpTPpTDK) was identified. Specifically, the protein levels of OEE2 increased as a result of grafting and displayed a higher abundance in plants during the juvenile and rejuvenated stages. Additionally, SsOEE2 displayed the highest expression levels in Sequoia shoots during the juvenile stage and less expression during the adult stage. The expression levels also steadily increased during grafting. Conclusion Our results indicate a positive correlation between the gene and protein expression patterns of SsOEE2 and the rejuvenation process, suggesting that this gene is involved in the rejuvenation of Sequoia sempervirens. PMID:21143964

  12. Monoamine oxidase B and free radical scavenging activities of natural flavonoids in Melastoma candidum D. Don.

    PubMed

    Lee, M H; Lin, R D; Shen, L Y; Yang, L L; Yen, K Y; Hou, W C

    2001-11-01

    Monoamine oxidase type B (MAO-B) activity and free radicals are elevated in certain neurological diseases. Four natural flavonoids, quercitrin, isoquercitrin, rutin, and quercetin, were isolated for the first time from the leaves of Melastoma candidum D. Don. They exhibited an inhibitory effect on MAO-B. These potent flavonoids were purified using bioassay-guided fractionation and were separated by Diaion, Sephadex LH-20, and MCI CHP20P columns. The IC(50) values of the four potent flavonoids, quercitrin, isoquercitrin, rutin, and quercetin on monoamine oxidase were 19.06, 11.64, 3.89, and 10.89 microM and enzyme kinetics analysis revealed apparent inhibition constants (K(i)) of 21.01, 2.72, 1.83, and 7.95 microM, respectively, on the substrate, benzylamine. The four potent compounds also exhibited hydroxyl radical scavenging activity as determined using a spin trapping electron spin resonance method. This suggests that the four flavonoids from M. candidum possess both MAO-B inhibitory and free radical scavenging activities. These important properties may be used for preventing some neurodegenerative diseases in the future.

  13. Longitudinal variability of size-fractionated N2 fixation and DON release rates along 24.5°N in the subtropical North Atlantic

    NASA Astrophysics Data System (ADS)

    Benavides, Mar; Bronk, Deborah A.; Agawin, Nona S. R.; PéRez-HernáNdez, M. Dolores; HernáNdez-Guerra, Alonso; AríStegui, Javier

    2013-07-01

    Dinitrogen (N2) fixation and dissolved organic nitrogen (DON) release rates were measured on fractionated samples (>10 µm and <10 µm) along 24.5∘N in the subtropical North Atlantic. Net N2 fixation rates (N2 assimilation into biomass) ranged from 0.01 to 0.4 nmol N L-1 h-1, and DON release rates ranged from 0.001 to 0.09 nmol N L-1 h-1. DON release represented ˜14% and ˜23% of >10 µm and <10 µm gross N2 fixation (assimilation into biomass plus DON release), respectively. This implies that by overlooking DON release, N2 fixation rates are underestimated. Net N2 fixation rates were higher in the east and decreased significantly toward the west (rs = -0.487, p = 0.002, and rs = -0.496, p = 0.001, for the >10 µm and <10 µm fractions, respectively). The sum of both fractions correlated with aerosol optical depth at 550 nm (AOD 550 nm) (rs = 0.382, p = 0.017) and phosphate (PO43-) concentrations (rs = 0.453, p = 0.018), suggesting an enhancement of diazotrophy as a response to aerosol inputs and phosphorus availability. In contrast, DON release was constant among size fractions and did not correlate with any of these variables. We also compared N2 fixation rates obtained using the 15N2 dissolved and bubble methods. The first gave average rates 50% (49% ± 39) higher than the latter, which supports the finding that previously published N2 fixation rates are likely underestimated. We suggest that by combining N2 fixation and DON release measurements using dissolved 15N2, global N2 fixation rates could increase enough to balance oceanic fixed nitrogen budget disequilibria.

  14. ALS insertion devices

    NASA Astrophysics Data System (ADS)

    Hoyer, E.; Chin, J.; Halbach, K.; Hassenzahl, W. V.; Humphries, D.; Kincaid, B.; Lancaster, H.; Plate, D.

    1991-08-01

    The Advanced Light Source (ALS), the first US third generation synchrotron radiation source, is currently under construction at the Lawrence Berkeley Laboratory. The low-emittance, 1.5 GeV electron storage ring and the insertion devices are specifically designed to produce high brightness beams in the UV to soft X-Ray range. The planned initial complement of insertion devices includes four 4.6 m long undulators, with period lengths of 3.9 cm, 5.0 cm (2) and 8.0 cm, and a 2.9 m long wiggler of 16 cm period length. Undulator design is well advanced and fabrication has begun on the 5.0 cm and 8.0 cm period length undulators. This paper discusses ALS insertion device requirements; general design philosophy; and design of the magnetic structure, support structure/drive systems, control system and vacuum system.

  15. [Introduction and transformation of the psychiatric term "anancasm". From Gyula (Julius) Donáth via Kurt Schneider to ICD-10].

    PubMed

    Steinberg, H

    2014-09-01

    The conceptual history of "anancasm" in psychiatry remains almost unexplored and this article will help to remove this deficit. It was the Budapest-based neuropsychiatrist Gyula Donáth (1849-1944) who first proposed this Greek-rooted term in 1897 as an international term for compulsive symptoms and as an independent mental illness similar to present-day obsessive compulsive disorders (ICD-10). By suggesting this term Donáth wanted to extend the concept of compulsion as proposed by his teacher Carl Westphal to other compulsive phenomena, psychomotor impulses and restrictions including echolalia, coprolalia, echokinesis, echopraxia, contemporary maladie des tics (present day Tourette's syndrome) and even intermittent dipsomania (craving for alcohol), paraphilias, sexual fetishes and homosexuality. In 1923 Kurt Schneider used this term for a subgroup of psychopathic personalities, the so-called insecure anancastic psychopaths. His concept was much different to that suggested by Donáth, with the only thing in common being the compulsory component. Schneider's anancasts suffered from feelings of insecurity and insufficiency and were forced to try to overcompensate by being excessively careful, meticulous and hyper-correct. Based on Schneider's concept anancasm has survived as a name for a subdivision of compulsive personality disorders in ICD-10; however, these rather complex personality defects were not what Donáth had in mind when he first suggested the term anancasm. The paper discusses further discrepancies between Donáth, Schneider and ICD-10.

  16. "Careworkers don't have a voice:" epistemological violence in residential care for older people.

    PubMed

    Banerjee, Albert; Armstrong, Pat; Daly, Tamara; Armstrong, Hugh; Braedley, Susan

    2015-04-01

    Drawing on feminist epistemologies, this paper attends to the way the reductionist assumptions have shaped the organization of nursing home carework in manners that are insufficient to the needs of relational care. This paper is informed by a study involving nine focus groups and a survey of Canadian residential care workers (141 RNs, 139 LPNs and 415 frontline careworkers). Four major themes were identified. Reductionist assumptions contributed to routinized, task-based approaches to care, resulting in what careworkers termed "assembly line care." Insufficient time and emphasis on the relational dimensions of care made it difficult to "treat residents as human beings." Accountability, enacted as counting and documenting, led to an "avalanche of paperwork" that took time away from care. Finally, hierarchies of knowledge contributed to systemic exclusions and the perception that "careworkers' don't have a voice." Careworkers reported distress as a result of the tensions between the organization of work and the needs of relational care. We theorize these findings as examples of "epistemological violence," a concept coined by Vandana Shiva (1988) to name the harm that results from the hegemony of reductionist assumptions. While not acting alone, we argue that reductionism has played an important role in shaping the context of care both at a policy and organizational level, and it continues to shape the solutions to problems in nursing home care in ways that pose challenges for careworkers. We conclude by suggesting that improving the quality of both work and care will require respecting the specificities of care and its unique epistemological and ontological nature.

  17. Rheum australe D. Don: a review of its botany, ethnobotany, phytochemistry and pharmacology.

    PubMed

    Rokaya, Maan Bahadur; Münzbergová, Zuzana; Timsina, Binu; Bhattarai, Krishna Ram

    2012-06-14

    Rheum australe D. Don (Polygonaceae) has been commonly used in traditional medicine for a wide range of ailments related to the circulatory, digestive, endocrine, respiratory and skeletal systems as well as to infectious diseases. To provide the up-to-date information that is available on the botany, traditional uses, phytochemistry, pharmacology and toxicology of Rheum australe. Additionally, to highlight the possible uses of this species to treat different diseases and to provide a basis for future research. The present review covers the literature available from 1980 to 2011. The information was collected from scientific journals, books, theses and reports via a library and electronic search (Google Scholar, Web of Science and ScienceDirect). Ethnomedical uses of Rheum australe have been recorded from China, India, Nepal and Pakistan for 57 different types of ailments. The phytochemical studies have shown the presence of many secondary metabolites belonging to anthraquinones, stilbenes, anthrones, oxantrone ethers and esters, chromones, flavonoids, carbohydrate, lignans, phenols and sterols. Crude extracts and isolated compounds from Rheum australe show a wide spectrum of pharmacological activities, such as antidiabetic, anti-inflammatory, antifungal, antimicrobial, antioxidant, anticancer, hepatoprotective and immune-enhancing activities, as well as a usefulness for improving renal function. Rheum australe has been widely used source of medicine for years without any adverse effects. Many studies have provided evidence for various traditional uses. However, there is a need for additional studies of the isolated compounds to validate the traditional uses in human models. The present review on the botany, traditional uses, phytochemistry and toxicity has provided preliminary information for further studies and commercial exploitations of the plant. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  18. Selection of Reliable Reference Genes for Gene Expression Studies on Rhododendron molle G. Don

    PubMed Central

    Xiao, Zheng; Sun, Xiaobo; Liu, Xiaoqing; Li, Chang; He, Lisi; Chen, Shangping; Su, Jiale

    2016-01-01

    The quantitative real-time polymerase chain reaction (qRT-PCR) approach has become a widely used method to analyze expression patterns of target genes. The selection of an optimal reference gene is a prerequisite for the accurate normalization of gene expression in qRT-PCR. The present study constitutes the first systematic evaluation of potential reference genes in Rhododendron molle G. Don. Eleven candidate reference genes in different tissues and flowers at different developmental stages of R. molle were assessed using the following three software packages: GeNorm, NormFinder, and BestKeeper. The results showed that EF1-α (elongation factor 1-alpha), 18S (18s ribosomal RNA), and RPL3 (ribosomal protein L3) were the most stable reference genes in developing rhododendron flowers and, thus, in all of the tested samples, while tublin (TUB) was the least stable. ACT5 (actin), RPL3, 18S, and EF1-α were found to be the top four choices for different tissues, whereas TUB was not found to favor qRT-PCR normalization in these tissues. Three stable reference genes are recommended for the normalization of qRT-PCR data in R. molle. Furthermore, the expression profiles of RmPSY (phytoene synthase) and RmPDS (phytoene dehydrogenase) were assessed using EF1-α, 18S, ACT5, RPL3, and their combination as internals. Similar trends were found, but these trends varied when the least stable reference gene TUB was used. The results further prove that it is necessary to validate the stability of reference genes prior to their use for normalization under different experimental conditions. This study provides useful information for reliable qRT-PCR data normalization in gene studies of R. molle. PMID:27803707

  19. You don't leave your baby--mother's experiences after a stillbirth.

    PubMed

    Lindgren, H; Malm, M C; Rådestad, I

    When a baby has died during pregnancy, the first encounter between mother and child occurs when the baby is already dead. Despair, emptiness, and grief characterize the encounter, which is also a gradual farewell to the child and the planned future for the family. This study describes mothers' experiences of the farewell of their stillborn baby at discharge from hospital. Twenty-three mothers from different parts of Sweden, who suffered stillbirth, were interviewed. Semi-structured questions were used and the replies were analyzed using content analysis. The mothers describe the separation from the child when leaving hospital as unnatural and that the separation ruins the motherhood they felt during pregnancy. Five categories were identified: unnatural to leave the baby; going home empty-handed; access to the child; security and insecurity in the separation; to let go. The overarching theme that we recognized from these responses we have formulated as: You don't leave your baby. Leaving the baby at the hospital goes against the biological instinct to care for and protect the offspring. Routines for a dignified goodbye including designating a deputy guardian into whose arms the mother can place the baby can help to facilitate the separation. The possibility of leaving the baby in the arms of someone known to the parents should be an option for parents who choose to take farewell of the child at the hospital. The place and time for the farewell should be decided on by the parents, taking the baby home for a personal farewell could be an alternative.

  20. Wound healing properties and kill kinetics of Clerodendron splendens G. Don, a Ghanaian wound healing plant

    PubMed Central

    Gbedema, Stephen Y.; Emelia, Kisseih; Francis, Adu; Kofi, Annan; Eric, Woode

    2010-01-01

    As part of our general objective of investigating indigenous plants used in wound healing in Ghana, we hereby report our findings from some in vitro and in vivo studies related to wound healing activities of Clerodendron splendens G. Don (Verbanaceae). Methanolic extract of the aerial parts of the plant was tested for antimicrobial activity against Gram positive bacteria (Bacillus subtilis, Staphylococcus aureus, Streptococcus faecalis, Micrococcus flavus, as well as resistant strains of Staph. aureus SA1199B, RN4220 and XU212), Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Proteous mirabilis, Klebsiella pneumoniae) and Candida albicans using the micro-well dilution method. Survivor–time studies of the microorganisms, radical scavenging activity using 2,2’-diphenylpicrylhydrazyl (DPPH) and various in vivo wound healing activity studies were also conducted on the extract. The extract exhibited biostatic action against all the test microorganisms with a Minimum Inhibition Concentration (MIC) ranging between 64 and 512 μg/ml and a free radical scavenging property with an IC50 value of 103.2 μg/ml. The results of the in vivo wound healing tests showed that upon application of C. splendens ointment, there was a reduction in the epithelization period from 26.7 days (control) to 13.6 days along with a marked decrease in the scar area from 54.2 mm2 (control) to 25.2 mm2. Significant increase in the tensile strength and hydroxyproline content were also observed as compared to the control and was comparable to nitrofurazone. The above results appear to justify the traditional use of C. splendens in wound healing and treatment of skin infections in Ghana. PMID:21808542

  1. Survey of genome sequences in a wild sweet potato, Ipomoea trifida (H. B. K.) G. Don

    PubMed Central

    Hirakawa, Hideki; Okada, Yoshihiro; Tabuchi, Hiroaki; Shirasawa, Kenta; Watanabe, Akiko; Tsuruoka, Hisano; Minami, Chiharu; Nakayama, Shinobu; Sasamoto, Shigemi; Kohara, Mitsuyo; Kishida, Yoshie; Fujishiro, Tsunakazu; Kato, Midori; Nanri, Keiko; Komaki, Akiko; Yoshinaga, Masaru; Takahata, Yasuhiro; Tanaka, Masaru; Tabata, Satoshi; Isobe, Sachiko N.

    2015-01-01

    Ipomoea trifida (H. B. K.) G. Don. is the most likely diploid ancestor of the hexaploid sweet potato, I. batatas (L.) Lam. To assist in analysis of the sweet potato genome, de novo whole-genome sequencing was performed with two lines of I. trifida, namely the selfed line Mx23Hm and the highly heterozygous line 0431-1, using the Illumina HiSeq platform. We classified the sequences thus obtained as either ‘core candidates’ (common to the two lines) or ‘line specific’. The total lengths of the assembled sequences of Mx23Hm (ITR_r1.0) was 513 Mb, while that of 0431-1 (ITRk_r1.0) was 712 Mb. Of the assembled sequences, 240 Mb (Mx23Hm) and 353 Mb (0431-1) were classified into core candidate sequences. A total of 62,407 (62.4 Mb) and 109,449 (87.2 Mb) putative genes were identified, respectively, in the genomes of Mx23Hm and 0431-1, of which 11,823 were derived from core sequences of Mx23Hm, while 28,831 were from the core candidate sequence of 0431-1. There were a total of 1,464,173 single-nucleotide polymorphisms and 16,682 copy number variations (CNVs) in the two assembled genomic sequences (under the condition of log2 ratio of >1 and CNV size >1,000 bases). The results presented here are expected to contribute to the progress of genomic and genetic studies of I. trifida, as well as studies of the sweet potato and the genus Ipomoea in general. PMID:25805887

  2. Lessons Learned from Sleep Education in Schools: A Review of Dos and Don'ts

    PubMed Central

    Blunden, Sarah; Rigney, Gabrielle

    2015-01-01

    Study Objectives: Sleep duration and quality are associated with negative neuropsychological and psychosocial outcomes in children and adolescents. However, community awareness of this is low and sleep education programs in schools are attempting to address this issue. Several studies now exist assessing the efficacy of these sleep education programs for improving sleep knowledge, sleep hygiene and sleep patterns. This paper presents these sleep education programs, most particularly, it presents the strengths and weaknesses of the current available studies in the hope that this can identify areas where future sleep education programs can improve. Methods: A systematic search of all school-based sleep education studies in adolescents was undertaken. Studies were scrutinized for author, teacher and participant comment regarding strengths and limitations of each study, which were then extracted and summarized. Results: Two specific types of sleep education programs emerged from the review, those that sought to change sleep behavior and those that sought simply to disseminate information. Issues that dictated the strength or weakness of a particular study including who delivers the program, the theoretical basis, the tools utilized to measure sleep patterns, the content, and their capacity to engage students were assessed. Sleep education was considered important by teachers, students and parents alike. Conclusions: Future sleep education programs need to take into account lessons learned from previous sleep education efforts in order to maximize the potential for sleep education programs to improve the sleep health of our young people. Commentary: A commentary on this article appears in this issue on page 595. Citation: Blunden S, Rigney G. Lessons learned from sleep education in schools: a review of dos and don'ts. J Clin Sleep Med 2015;11(6):671–680. PMID:25766709

  3. Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways.

    PubMed

    Lin, Jiumao; Chen, Youqin; Cai, Qiaoyan; Wei, Lihui; Zhan, Youzhi; Shen, Aling; Sferra, Thomas J; Peng, Jun

    2014-05-01

    The pathogenic mechanisms underlying cancer development are complex and heterogeneous, involving multiple cellular signaling transduction pathways that usually function redundantly. In addition, crosstalk between these pathways generates a complicated and robust signaling network that is regulated by compensatory mechanisms. Given the complexity of cancer pathogenesis and progression, many of the currently used antitumor agents, which typically target a single intracellular pathway, might not always be effective on complex tumor systems. Moreover, long-term use of these agents often generates drug resistance and toxicity against normal cells. Therefore, the development of novel anticancer chemotherapies is urgently needed.Scutellaria barbataD Don (SB) is a medicinal herb that has long been used in China to treat various types of cancer. We previously reported that the ethanol extract of SB (EESB) is able to induce colon cancer cell apoptosis, inhibit cell proliferation and tumor angiogenesis via modulation of several pathways, including Hedgehog, Akt, and p53. To further elucidate the precise mechanisms of SB's antitumor activity, using a colorectal cancer (CRC) mouse xenograft model in the present study, we evaluated the therapeutic efficacy and molecular mechanisms of EESB against tumor growth. We found that EESB reduced tumor volume and tumor weight but had no effect on body weight gain in CRC mice, demonstrating that EESB could inhibit colon cancer growth in vivo without apparent adverse effect. In addition, EESB treatment could significantly suppress the activation of several CRC-related pathways, including STAT3, Erk, and p38 signalings in tumor tissues, and alter the expression of multiple critical target genes such as Bcl-2, Bax, Cyclin D1, CDK4, and p21. These molecular effects lead to the induction of cancer cell apoptosis and inhibition of cell proliferation. Our findings demonstrate that SB possesses a broad range of antitumor activities because of its

  4. Supercritical Extraction of Scopoletin from Helichrysum italicum (Roth) G. Don Flowers.

    PubMed

    Jokić, Stela; Rajić, Marina; Bilić, Blanka; Molnar, Maja

    2016-09-01

    The increasing popularity of immortelle (Helichrysum italicum (Roth) G. Don) and its products, particularly in the cosmetic industry, is evident nowadays. This plant is a source of coumarins, especially scopoletin, which are highly soluble in supercritical CO2 . The objective of this study was to perform the supercritical CO2 extraction process of Helichrysum italicum flowers at different values of pressure and temperature and to optimise the extraction process using response surface methodology in terms of obtaining the highest extraction yield and yield of extracted scopoletin. Extraction was performed in a supercritical extraction system under different extraction conditions of pressure and temperature determined by central composite rotatable design. The mass of flowers in the extractor of 40 g, extraction time of 90 min and CO2 mass flow rate of 1.94 kg/h were kept constant during experiments. Antioxidant activity was determined using the DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging assay method. Scopoletin concentration was determined by HPLC. Changes in extraction conditions affect the extracting results remarkably. The greatest extraction yield (6.31%) and the highest yield of scopoletin (1.933 mg/100 g) were obtained under extraction conditions of 20 MPa and 40°C. Extracts have also proven to possess antioxidant activity (44.0-58.1% DPPH scavenging activity) influenced by both temperature and pressure applied within the investigated parameters. The extraction conditions, especially pressure, exhibited significant influence on the extraction yield as well as the yield of extracted scopoletin and antioxidant activity of extracts. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  5. Al Jazirah, Sudan

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Al Jazirah (also Gezira) is one of the 26 states of Sudan. The state lies between the Blue Nile and the White Nile in the east-central region of the country. It is a well populated area suitable for agriculture. The area was at the southern end of Nubia and little is known about its ancient history and only limited archaeological work has been conducted in this area. The region has benefited from the Gezira Scheme, a program to foster cotton farming begun in 1925. At that time the Sennar Dam and numerous irrigation canals were built. Al Jazirah became the Sudan's major agricultural region with more than 2.5 million acres (10,000 km) under cultivation. The initial development project was semi-private, but the government nationalized it in 1950. Cotton production increased in the 1970s but by the 1990s increased wheat production has supplanted a third of the land formerly seeded with cotton.

    The image was acquired December 25, 2006, covers an area of 56 x 36.4 km, and is located near 14.5 degrees north latitude, 33.1 degrees east longitude.

    The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

  6. Al Jazirah, Sudan

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Al Jazirah (also Gezira) is one of the 26 states of Sudan. The state lies between the Blue Nile and the White Nile in the east-central region of the country. It is a well populated area suitable for agriculture. The area was at the southern end of Nubia and little is known about its ancient history and only limited archaeological work has been conducted in this area. The region has benefited from the Gezira Scheme, a program to foster cotton farming begun in 1925. At that time the Sennar Dam and numerous irrigation canals were built. Al Jazirah became the Sudan's major agricultural region with more than 2.5 million acres (10,000 km) under cultivation. The initial development project was semi-private, but the government nationalized it in 1950. Cotton production increased in the 1970s but by the 1990s increased wheat production has supplanted a third of the land formerly seeded with cotton.

    The image was acquired December 25, 2006, covers an area of 56 x 36.4 km, and is located near 14.5 degrees north latitude, 33.1 degrees east longitude.

    The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

  7. AL Amyloidosis and Agent Orange

    MedlinePlus

    ... for survivors' benefits . Research on AL amyloidosis and herbicides The Health and Medicine Division (formally known as ... to the compounds of interest found in the herbicide Agent Orange and AL amyloidosis." VA made a ...

  8. Al Qaeda as a System

    DTIC Science & Technology

    2006-03-15

    either as welcome guests or parasites . As welcome guests, Al Qaeda members take sanctuary in sponsor states. Sponsor states provide Al Qaeda with...sponsorship, Al Qaeda takes sanctuary as parasites either overtly or covertly. They take overt sanctuary in countries that publicly claim a policy...39 Yehudit Barsky, “Al Qa’ida, Iran, and Hezbollah: A Continuing Symbiosis ,” The American Jewish Committee Series on Terrorism , February 2004, 2-3

  9. Al(+)-ligand binding energies

    NASA Technical Reports Server (NTRS)

    Sodupe, M.; Bauschlicher, Charles W., Jr.

    1991-01-01

    Ab initio calculations are used to optimize the structure and determine the binding energies of Al(+) to a series of ligands. For Al(+)-CN, the bonding was found to have a large covalent component. For the remaining ligands, the bonding is shown to be electrostatic in origin. The results obtained for Al(+) are compared with those previously reported for Mg(+).

  10. [Interrelations of forest and steppe elements in the fauna of herpetobionts of the middle and lower Don river steppe zone].

    PubMed

    Cherednikov, S Iu; Utianskaia, S V

    2000-01-01

    Herpetobionts of the forest and steppe biocoenoses were studied in the region of their contact under the conditions of the Middle and Lower Don flow limiting for the forest existence. The species composition of coleopterans of the ravine forests comprises 96 species. The dominant complex of herpetobionts of the steppe and ravine forest biocoenoses includes 13 and 9 species, respectively. Forest species predominate in both forest and steppe habitats of the northern regions, while the meadow species, predominate in the southern regions. The forest species Carabus excellens was found in the steppe zone (oak forest of the Derkul' skii region) for the first time.

  11. Linkage mapping and identification of QTL affecting deoxynivalenol (DON) content (Fusarium resistance) in oats (Avena sativa L.).

    PubMed

    He, Xinyao; Skinnes, Helge; Oliver, Rebekah E; Jackson, Eric W; Bjørnstad, Asmund

    2013-10-01

    Mycotoxins caused by Fusarium spp. is a major concern on food and feed safety in oats, although Fusarium head blight (FHB) is often less apparent than in other small grain cereals. Breeding resistant cultivars is an economic and environment-friendly way to reduce toxin content, either by the identification of resistance QTL or phenotypic evaluation. Both are little explored in oats. A recombinant-inbred line population, Hurdal × Z595-7 (HZ595, with 184 lines), was used for QTL mapping and was phenotyped for 3 years. Spawn inoculation was applied and deoxynivalenol (DON) content, FHB severity, days to heading and maturity (DH and DM), and plant height (PH) were measured. The population was genotyped with DArTs, AFLPs, SSRs and selected SNPs, and a linkage map of 1,132 cM was constructed, covering all 21 oat chromosomes. A QTL for DON on chromosome 17A/7C, tentatively designated as Qdon.umb-17A/7C, was detected in all experiments using composite interval mapping, with phenotypic effects of 12.2–26.6 %. In addition, QTL for DON were also found on chromosomes 5C, 9D, 13A, 14D and unknown_3, while a QTL for FHB was found on 11A. Several of the DON/FHB QTL coincided with those for DH, DM and/or PH. A half-sib population of HZ595, Hurdal × Z615-4 (HZ615, with 91 lines), was phenotyped in 2011 for validation of QTL found in HZ595, and Qdon.umb-17A/7C was again localized with a phenotypic effect of 12.4 %. Three SNPs closely linked to Qdon.umb-17A/7C were identified in both populations, and one each for QTL on 5C, 11A and 13A were identified in HZ595. These SNPs, together with those yet to be identified, could be useful in marker-assisted selection to pyramiding resistance QTL.

  12. Doppelthydrophile Blockcopolymere als Mineralisationstemplate

    NASA Astrophysics Data System (ADS)

    Kasparova, Pavla

    2002-07-01

    Die vorliegende Arbeit beschäftigt sich mit der Synthese und den Eigenschaften von doppelthydrophilen Blockcopolymeren und ihrer Anwendung in einem biomimetischen Mineralisationsprozeß von Calciumcarbonat und Bariumsulfat. Doppelthydrophile Blockcopolymere bestehen aus einem hydrophilen Block, der nicht mit Mineralien wechselwirkt und einem zweiten Polyelektrolyt-Block, der stark mit Mineraloberflächen wechselwirkt. Diese Blockcopolymere wurden durch ringöffnende Polymerisation von N-carboxyanhydriden (NCA's) und a-methoxy-ω-amino[poly(ethylene glycol)] PEG-NH2 als Initiator hergestellt. Die hergestellten Blockcopolymere wurden als effektive Wachstumsmodifikatoren für die Kristallisation von Calciumcarbonat und Bariumsulfat Mineralien eingesetzt. Die so erhaltenen Mineralpartikel (Kugeln, Hantel, eiförmige Partikel) wurden durch Lichtmikroskopie in Lösung, SEM und TEM charakterisiert. Röntgenweitwinkelstreuung (WAXS) wurde verwendet, um die Modifikation von Calciumcarbonat zu ermitteln und die Größe der Calciumcarbonat- und Bariumsulfat-Nanopartikel zu ermitteln. This work describes the synthesis and characterization of double hydrophilic block copolymers and their use in a biomimetic mineralization process of Calcium Carbonate and Barium Sulfate. Double hydrophilic block copolymers consist of a hydrophilic block that does not interact with minerals and another hydrophilic polyelectrolyte block that strongly interacts with mineral surfaces. These polymers were synthesised via ring opening polymerisation of N-carboxyanhydride (NCA), and the first hydrophilic block a-methoxy-ω-amino[poly(ethylene glycol)] PEG-NH2 was used as an initiator. The prepared block copolymers were used as effective crystal growth modifiers to control the crystallization of Calcium Carbonate and Barium Sulfate minerals. The resulting mineral particles (spheres, dumbbells, egg-like particles) were characterised by light microscopy in solution, by SEM, and by TEM. X-Ray scattering

  13. Submicron Nb-Al/Al oxide-Nb tunnel junctions sandwiched between Al films

    NASA Astrophysics Data System (ADS)

    Maier, D.; Rothermel, H.; Gundlach, K. H.; Zimmermann, R.

    1996-02-01

    A process has been developed to embed Nb-Al/Al oxide-Nb junctions in planar structures of Al films. The submicron junctions are defined by photoresist lines. Motivation for this effort is a possible application of Nb junctions confined between normal conducting Al films as mixers above 700 GHz where Nb films loose their superconductive properties and tuning circuits made out of Nb therefore exhibit losses. First mixer results at 816 GHz are presented.

  14. Goldwater-Nichols: Military-run versus Civilian-run Acquisition: Will the Twain Ever Meet in the DoN?

    DTIC Science & Technology

    2010-04-30

    Military-run versus Civilian-run Acquisition: Will the Twain Ever Meet in the DoN? 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...Goldwater-Nichols: Military-run versus Civilian-run Acquisition: Will the Twain Ever Meet in the DoN? Irv Blickstein—Mr. Blickstein is a Senior Engineer...developed parallel processes that are marked by division, discord and a lack of cooperation. The military side, building requirements, and the

  15. Growth and Optical Properties of Al rich AlN/AlGaN Quantum Wells

    NASA Astrophysics Data System (ADS)

    Tahtamouni, T. M. Al; Nepal, N.; Nakarmi, M. L.; Lin, J. Y.; Jiang, H. X.

    2006-03-01

    Al rich AlGaN alloys are promising materials for the applications in the optoelectronic devices such as deep ultraviolet (UV) emitters and detectors in the spectral range down to 200 nm. AlGaN based UV emitters (λ<340nm) has applications in bio-chemical agent detection and medical research/ health care. To realize deep UV emission (λ< 280 nm) Al rich AlGaN based quantum wells (QWs) are required. We report here the growth of AlN/AlxGa1-xNQWs (x>0.65) on AlN/sapphire templates by metalorganic chemical vapor deposition (MOCVD). Deep UV photoluminescence (PL) was employed to study the optical properties of the QWs. Well width (Al composition) dependence was studied by varying the QW thickness (Al composition) with fixed x ˜ 0.65 (well width at 3 nm). Optical properties of these QWs such as the effects of alloy fluctuation, temperature, strain and piezoelectric field, carrier and exciton localizations on the quantum efficiency have been studied. Carrier and exciton dynamics were probed. Implications of our findings on the applications of Al rich AlN/AlGaN QWs for UV emitters and detectors will also be discussed.

  16. Studies of 27Al NMR in SrAl4

    NASA Astrophysics Data System (ADS)

    Niki, Haruo; Higa, Nonoka; Kuroshima, Hiroko; Toji, Tatsuki; Morishima, Mach; Minei, Motofumi; Yogi, Mamoru; Nakamura, Ai; Hedo, Masato; Nakama, Takao; Ōnuki, Yoshichika; Harima, Hisatomo

    A charge density wave (CDW) transition at TCDW = 243 K and a structural phase (SP) transition at approximately 100 K occur in SrAl4 with the BaAl4-type body center tetragonal structure, which is the divalent and non-4f electron reference compound of EuAl4. To understand the behaviors of the CDW and SP transitions, the 27Al NMR measurements using a single crystal and a powder sample of SrAl4 have been carried out. The line width below TCDW is modulated by an electrical quadruple interaction between 27Al nucleus and CDW charge modulation. The incommensurate CDW state below TCDW changes into a different structure below TSP. The temperature dependences of Knight shifts of 27Al(I) and 27Al(II) show the different behaviors. The temperature variation of 27Al(I) Knight shift shows anomalies at the CDW and SP transition temperatures, revealing the shift to negative side below TCDW, which is attributable to the core polarization of the d-electrons. However, 27Al(II) Knight shift keeps almost constant except for the small shift due to the SP transition. The 1/T1T of 27Al(I) indicates the obvious changes due to the CDW and SP transitions, while that of 27Al(II) takes a constant value. The density of state at the Fermi level at Al(I) site below 60 K would be about 0.9 times less than that above TCDW.

  17. Why Don't We Already Have an Integrated Framework for the Publication and Preservation of All Data Products?

    NASA Astrophysics Data System (ADS)

    Accomazzi, A.; Derriere, S.; Biemesderfer, C.; Gray, N.

    2012-09-01

    Astronomy has long had a working network of archives supporting the curation of publications and data. The discipline has already created many of the features which perplex other areas of science: (1) data repositories: (supra)national institutes, dedicated to large projects; a culture of user-contributed data; practical experience of long-term data preservation; (2) dataset identifiers: the community has already piloted experiments, knows what can undermine these efforts, and is participating in the development of next-generation standards; (3) citation of datasets in papers: the community has an innovative and expanding infrastructure for the curation of data and bibliographic resources, and through them a community of authors and editors familiar with such electronic publication efforts; as well, it has experimented with next-generation web standards (e.g. the Semantic Web); (4) publisher buy-in: publishers in this area have been willing to innovate within the constraints of their commercial imperatives. What can possibly be missing? Why don't we have an integrated framework for the publication and preservation of all data products already? Are there technical barriers? We don't believe so. Are there cultural or commercial forces inhibiting this? We aren't aware of any. This Birds of a Feather session (BoF) attempted to identify existing barriers to the creation of such a framework, and attempted to identify the parties or groups which can contribute to the creation of a VO-powered data-publishing framework.

  18. Le don après un décès d'origine cardiocirculatoire au Canada

    PubMed Central

    Shemie, Sam D.; Baker, Andrew J.; Knoll, Greg; Wall, William; Rocker, Graeme; Howes, Daniel; Davidson, Janet; Pagliarello, Joe; Chambers-Evans, Jane; Cockfield, Sandra; Farrell, Catherine; Glannon, Walter; Gourlay, William; Grant, David; Langevin, Stéphan; Wheelock, Brian; Young, Kimberly; Dossetor, John

    2006-01-01

    Résumé Ces recommandations sont le fruit d'un processus multidisciplinaire national ayant duré un an et visant à déterminer si et comment l'on pourrait procéder au don d'organes après un décès d'origine cardiocirculatoire («don après le décès cardiocirculatoire», ou DDC) au Canada. Le forum national organisé en février 2005 a permis aux participants de discuter et d'élaborer des recommandations sur les principes, interventions et pratiques se rapportant au DDC. Les aspects éthiques et juridiques ont été abordés dans les discussions. À la fin du Forum, la majorité des participants ont été favorables à l'implantation de programmes de DDC au Canada. Les participants du Forum ont également convenu qu'il fallait formuler et prôner des valeurs fondamentales pour orienter l'élaboration de programmes et de protocoles basés sur le cadre médical, éthique et juridique établi lors de cette réunion. Même si la possibilité d'un don d'organes et de tissus doit faire partie intégrante des soins de fin de vie, il faut insister sur le fait que le devoir de diligence envers les patients mourants et leurs familles doit demeurer la priorité des équipes soignantes. La complexité et les répercussions profondes du décès sont reconnues et doivent être respectées, de même que les différences personnelles, ethnoculturelles et religieuses face à la mort et au don d'organes. Les décisions d'arrêter le traitement de maintien des fonctions vitales, la prise en charge des derniers moments de la vie et le diagnostic de décès selon des critères cardiocirculatoires doivent être distincts et indépendants des processus de don et transplantation. Ce rapport contient des recommandations destinées aux gestionnaires de program, aux autorités sanitaires régionales et aux instances appelés à élaborer les protocoles de DDC. Les programmes doivent être conçus en fonction des éléments suivants : direction et planification locales, éducation et

  19. UMTRA water sampling technical (peer) review: Responses to observations, comments, and recommendations submitted by Don Messinger (Roy F. Weston, Inc.)

    SciTech Connect

    1993-08-01

    An independent technical review (peer review) was conducted during the period of September 15--17, 1992. The review was conducted by C. Warren Ankerberg (Geraghty and Miller, Inc., Tampa, Florida) and Don Messinger (Roy F. Weston, Inc., West Chester, Pennsylvania). The review was held at Jacobs Engineering in Albuquerque, New Mexico, and at the Shiprock, New Mexico, site. The peer review included a review of written documentation [water sampling standard operating procedures (SOP)], an inspection of technical reports and other deliverables, a review of staff qualifications and training, and a field visit to evaluate the compliance of field procedures with SOPS. Upon completion of the peer review, each reviewer independently prepared a report of findings from the review. The reports listed findings and recommended actions. This document responds to the observations, comments, and recommendations submitted by Don Messinger following his review. The format of this document is to present the findings and recommendations verbatim from Mr. Messinger`s report, followed by responses from the UMTRA Project staff. Included in the responses from the UMTRA Project staff are recommended changes in SOPs and strategies for implementing the charges.

  20. Morton et al. Reply

    NASA Technical Reports Server (NTRS)

    Morton, Douglas C.; Nagol, Jyoteshwar; Carabajal, Claudia C.; Rosette, Jacqueline; Palace, Michael; Cook, Bruce D.; Vermote, Eric F.; Harding, David J.; North, Peter R. J.

    2016-01-01

    Multiple mechanisms could lead to up-regulation of dry-season photosynthesis in Amazon forests, including canopy phenology and illumination geometry. We specifically tested two mechanisms for phenology-driven changes in Amazon forests during dry-season months, and the combined evidence from passive optical and lidar satellite data was incompatible with large net changes in canopy leaf area or leaf reflectance suggested by previous studies. We therefore hypothesized that seasonal changes in the fraction of sunlit and shaded canopies, one aspect of bidirectional reflectance effects in Moderate Resolution Imaging Spectroradiometer (MODIS) data, could alter light availability for dry-season photosynthesis and the photosynthetic capacity of Amazon forests without large net changes in canopy composition. Subsequent work supports the hypothesis that seasonal changes in illumination geometry and diffuse light regulate light saturation in Amazon forests. These studies clarify the physical mechanisms that govern light availability in Amazon forests from seasonal variability in direct and diffuse illumination. Previously, in the debate over light limitation of Amazon forest productivity, seasonal changes in the distribution of light within complex Amazon forest canopies were confounded with dry-season increases in total incoming photosynthetically active radiation. In the accompanying Comment, Saleska et al. do not fully account for this confounding effect of forest structure on photosynthetic capacity.

  1. Morton et al. Reply

    NASA Technical Reports Server (NTRS)

    Morton, Douglas C.; Nagol, Jyoteshwar; Carabajal, Claudia C.; Rosette, Jacqueline; Palace, Michael; Cook, Bruce D.; Vermote, Eric F.; Harding, David J.; North, Peter R. J.

    2016-01-01

    Multiple mechanisms could lead to up-regulation of dry-season photosynthesis in Amazon forests, including canopy phenology and illumination geometry. We specifically tested two mechanisms for phenology-driven changes in Amazon forests during dry-season months, and the combined evidence from passive optical and lidar satellite data was incompatible with large net changes in canopy leaf area or leaf reflectance suggested by previous studies. We therefore hypothesized that seasonal changes in the fraction of sunlit and shaded canopies, one aspect of bidirectional reflectance effects in Moderate Resolution Imaging Spectroradiometer (MODIS) data, could alter light availability for dry-season photosynthesis and the photosynthetic capacity of Amazon forests without large net changes in canopy composition. Subsequent work supports the hypothesis that seasonal changes in illumination geometry and diffuse light regulate light saturation in Amazon forests. These studies clarify the physical mechanisms that govern light availability in Amazon forests from seasonal variability in direct and diffuse illumination. Previously, in the debate over light limitation of Amazon forest productivity, seasonal changes in the distribution of light within complex Amazon forest canopies were confounded with dry-season increases in total incoming photosynthetically active radiation. In the accompanying Comment, Saleska et al. do not fully account for this confounding effect of forest structure on photosynthetic capacity.

  2. Rub' al Khali, Arabia

    NASA Technical Reports Server (NTRS)

    2008-01-01

    The Rub' al Khali is one of the largest sand deserts in the world, encompassing most of the southern third of the Arabian Peninsula. It includes parts of Oman, United Arab Emirates, and Yemen. The desert covers 650,000 square kilometers, more than the area of France. Largely unexplored until recently, the desert is 1000 km long and 500 km wide. The first documented journeys made by Westerners were those of Bertram Thomas in 1931 and St. John Philby in 1932. With daytime temperatures reaching 55 degrees Celsius, and dunes taller than 330 meters, the desert may be one of the most forbidding places on Earth.

    The image was acquired December 2, 2005, covers an area of 54.8 x 61.9 km, and is located near 20.7 degrees north latitude, 53.6 degrees east longitude.

    The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

  3. Weird genotypes? Don't discard them, transmissible cancer could be an explanation.

    PubMed

    Riquet, Florentine; Simon, Alexis; Bierne, Nicolas

    2017-02-01

    Genetic chimerism is rarely considered in the analysis of population genetics data, because assumed to be an exceptionally rare, mostly benign, developmental accident. An unappreciated source of chimerism is transmissible cancer, when malignant cells have become independent parasites and can infect other individuals. Parasitic cancers were thought to be rare exceptions, only reported in dogs (Murgia et al., Cell, 2006, 126, 477; Rebbeck et al., Evolution, 2009, 63, 2340), Tasmanian devils (Pearse and Swift, Nature, 2006, 439, 549; Pye et al., Proceedings of the National Academy of Sciences, 2016, 113, 374), and soft-shell clams (Metzger et al., Cell, 2015, 161, 255). However, the recent simultaneous report of four new contagious leukemias in marine mollusks (Metzger et al., Nature, 2016, 534, 705) might change the rules. By doubling up the number of naturally occurring transmissible cancers, this discovery suggests they may essentially be missed because not sufficiently searched for, especially outside mammals. We encourage population geneticists to keep in mind infectious cancer when interpreting weird genotypes in their molecular data. It would then contribute in the investigation of how widespread contagious cancer could really be in the wild. We provide an example with our own data in Mytilus mussels, a commercially important shellfish. We identified genetic chimerism in a few mussels that suggests the possible occurrence at low prevalence in European M. edulis populations of a M. trossulus contagious cancer related to the one described by Metzger et al. (Nature, 2016, 534, 705) in populations of British Columbia.

  4. The Evolution of Al Qaeda

    DTIC Science & Technology

    2007-06-15

    www.carleton.ca/cciss/res_docs/itac/gendron_e.pdf; Internet. 26Muhammad Abd al-salam Faraj, Al-Farīdah al-Ghā’ibah, trans. Johannes J.G. Jansen and... Theo Van Gogh.91 Hoffman also supports the idea proposed by other experts like Benjamin Orbach and Keith Blanchard of the Congressional Research...religious intolerance over cartoons in Danish newspapers, the assassination of Theo Van Goeh, and increasing discontent among disassociated Muslim

  5. Alexandria (Al Iskandariya), Egypt

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This image of Alexandria was taken by astronauts on board the International Space Station in December 2000 using an Electronic Still Camera. A wider-angle view (STS088-739-90) taken from the Space Shuttle in December 1998 is available for context. Alexandria (Al Iskandariya) occupies a T-shaped peninsula and strip of land separating the Mediterranean from Lake Mariout. Originally the town was built upon a mole (stone breakwater) called Heptastadium, which joined the island of Pharos (see referenced website, below) to the mainland. Since then sedimentary deposits have widened the mole. Since 1905, when the 370,000 Alexandrians lived in an area of about 4 sq km between the two harbors, the city (population 4 million; see referenced website, below) has grown beyond its medieval walls and now occupies an area of about 300 sq km. The Mahmudiya Canal, connecting Alexandria with the Nile, runs to the south of the city and, by a series of locks, enters the harbor of the principal port of Egypt (note ships). The reddish and ochre polygons west of Lake Mariout are salt-evaporation, chemical-storage, and water-treatment ponds within the coastal lagoon. Reference Youssef Halim and Fatma Abou Shouk, 2000, Human impacts on Alexandria's marine environment: UNESCO, Coastal Regions and Small Islands Unit (CSI), Coastal Management Sourcebooks 2 (accessed December 20, 2000) Additional photographs taken by astronauts can be viewed at NASA-JSC's Gateway to Astronaut Photography of Earth. Image ISS001-ESC-5025 provided by the Earth Sciences and Image Analysis Laboratory, Johnson Space Center.

  6. Is there a paraneoplastic ALS?

    PubMed

    Corcia, Philippe; Gordon, Paul H; Camdessanche, Jean-Philippe

    2015-06-01

    Our objective was to examine the strength of evidence in support of the paraneoplastic syndrome (PNS) as one cause of ALS and, if the association appears more likely than chance, determine which features of ALS imply concurrent malignancy. We reviewed the literature on concurrent ALS and neoplasia assessing the strength of evidence for the association. Most accounts of ALS and neoplasm are case reports or small uncontrolled series. In order of strength of evidence, three clinical situations that support a paraneoplastic aetiology for ALS are: 1) laboratory evidence of well-characterized onconeuronal antibodies, most often anti-Hu, anti-Yo or anti-Ri; 2) co-occurrence of ALS and a neoplasm known to cause PNS, usually lymphoma or cancer of the breast; and 3) combined ALS and a neoplasm not classically associated with PNS, without detectable onconeuronal antibodies. Clinical features that warrant evaluation of neoplasm include upper motor neuron disease in elderly females, rapid progression, non-motor signs, and young onset. In conclusion, most examples of ALS and neoplasm do not constitute a classically established PNS. Rare instances of elevated onconeuronal antibody titres or typical neoplasm, implies that, albeit rare, the PNS is one of a multitude of causes of ALS.

  7. Understanding ALS: new therapeutic approaches.

    PubMed

    Musarò, Antonio

    2013-09-01

    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with motor neuron degeneration, muscle atrophy and paralysis. Although numerous pathological mechanisms have been elucidated, ALS remains an invariably fatal disease in the absence of any effective therapy. The heterogeneity of the disease and the failure to develop satisfactory therapeutic protocols reinforce the view that ALS is a multi-factorial and multi-systemic disease. Thus, a better understanding of the pathogenic mechanisms and study of the potential pathological relationship between the various cellular processes is required to ensure efficacious therapy. The pathogenic mechanisms associated with ALS are reviewed, and the strengths and limitations of some new therapeutic approaches are discussed.

  8. "This Is My Body Which Will Be Given up for You": Federico Garcia Lorca's "Amor de Don Perlimplin" and the "Auto Sacramental" Tradition

    ERIC Educational Resources Information Center

    Badenes, Jose Ignacio

    2009-01-01

    "Amor de Don Perlimplin con Belisa en su jardin" is one of Federico Garcia Lorca's shortest plays as well as one of his deepest. Its theme is love, particularly the interaction between spiritual longing and carnal desire, body and soul, humanity and divinity. These are aspects found in Roman Catholic Eucharistic theology which the…

  9. "How People Read and Write and They Don't Even Notice": Everyday Lives and Literacies on a Midlands Council Estate

    ERIC Educational Resources Information Center

    Jones, Susan

    2014-01-01

    This article presents data from a British Academy-funded study of the everyday literacy practices of three families living on a predominantly white working-class council housing estate on the edge of a Midlands city. The study explored, as one participant succinctly put it, "how people read and write and they don't even notice". This…

  10. Distribution of polycyclic aromatic hydrocarbons in surface sediments of lower reaches of the Don River (Russia) and their ecotoxicologic assessment by bacterial lux-biosensors.

    PubMed

    Sazykin, I S; Sazykina, M A; Khammami, M I; Kostina, N V; Khmelevtsova, L E; Trubnik, R G

    2015-05-01

    The lower Don River in the south of the European part of Russia was studied to determine the concentration, spatial distribution, and sources of 19 polycyclic aromatic hydrocarbons (PAHs) in surface sediments. Total PAH concentrations ranged from 14.2 to 529 ng/g-dw. Sedimentary PAH concentrations were higher in the delta of the Don River and in the estuaries of rivers Sal and Aksai compared to the main channel of the Don. Analysis of the PAHs sources showed that PAHs came mostly from pyrogenic sources as a result of incomplete combustion of coal. Bioluminescent bacterial sensors were used for ecotoxicological assessment of surface sediments. The surface sediments of all the investigated stations of lower reaches of the Don River were toxic and genotoxic. The maximum concentration of PAHs and the high genotoxicity effect caused by the presence of genotoxicants were found in the surface sediments of the same stations. Significant correlations between the concentrations of individual PAHs in sediments and the genotoxic effect were found. Correlation between genotoxicity of surface sediments and concentration of phenanthrene and benz(k)fluoranthene was the most significant both with and without application of metabolic activation.

  11. "How People Read and Write and They Don't Even Notice": Everyday Lives and Literacies on a Midlands Council Estate

    ERIC Educational Resources Information Center

    Jones, Susan

    2014-01-01

    This article presents data from a British Academy-funded study of the everyday literacy practices of three families living on a predominantly white working-class council housing estate on the edge of a Midlands city. The study explored, as one participant succinctly put it, "how people read and write and they don't even notice". This…

  12. An assistive device designed to convey independent donning of a shuttle lock trans-tibial prosthesis for a multiple limb amputee.

    PubMed

    Tamir, E; Heim, M; Oppenheim, U; Siev-Ner, I

    2003-04-01

    This contribution describes a simple device designed to convey independent donning of a shuttle lock trans-tibial prosthesis for a multiple limb amputee. The device is made of a post with a shuttle lock mechanism at one end and a plate covered by rubber at the other end. This device enables correct positioning of the silicone liner and independent attachment to the prosthesis.

  13. Analysis of the small interfering RNA profiles of randomly inserted pTRM-TRI6 Fusarium graminearum mutants and their DON related phenotypes

    USDA-ARS?s Scientific Manuscript database

    Deoxynivalenol (DON) production by Fusarium graminearum requires activation of the trichothecene pathway in which TRI5 catalyzes the first step of trichothecene synthesis and TRI6 is a transcription factor activates the pathway. RNA interference (RNAi) has emerged as a useful fungal genetics tool f...

  14. "This Is My Body Which Will Be Given up for You": Federico Garcia Lorca's "Amor de Don Perlimplin" and the "Auto Sacramental" Tradition

    ERIC Educational Resources Information Center

    Badenes, Jose Ignacio

    2009-01-01

    "Amor de Don Perlimplin con Belisa en su jardin" is one of Federico Garcia Lorca's shortest plays as well as one of his deepest. Its theme is love, particularly the interaction between spiritual longing and carnal desire, body and soul, humanity and divinity. These are aspects found in Roman Catholic Eucharistic theology which the…

  15. Helping Teams Succeed: An Essay Review of "Groups That Work (and Those That Don't): Creating Conditions for Effective Teamwork."

    ERIC Educational Resources Information Center

    Kain, Daniel L.

    1993-01-01

    Teams are incompatible with the scientific management philosophy underlying traditional curricular and organizational theory. This article examines J. R. Hackman's book "Groups That Work (and Those That Don't): Creating Conditions for Effective Teamwork" (1990), as it illuminates the experience of teaching on a middle school…

  16. Impurity Enhancement of Al_2O_3/Al Adhesion

    NASA Astrophysics Data System (ADS)

    Wang, Xiao-Gang; Smith, John R.; Zhang, Wenqing; Evans, Anthony

    2003-03-01

    Our first-principles computations indicate that the clean Al_2O_3/Al interface is relatively weak - weaker than bulk Al. Fracture experiments reveal that the interface is relatively strong with observed failure in bulk Al, however. This paradox is resolved via doping effects of the common impurity C. We have found that only 1/3 of a monolayer of carbon segregated to the interface can increase the work of separation by a factor of 3. The resulting strong interface is consistent with fracture experiments. It arises due to void formation in the interface, which provides low-strain sites for the carbon to segregate to. The degree of void formation is consistent with the relatively high heat of oxide formation of Al.

  17. Interfacial characterization of Al-Al thermocompression bonds

    SciTech Connect

    Malik, N.; Carvalho, P. A.; Poppe, E.; Finstad, T. G.

    2016-05-28

    Interfaces formed by Al-Al thermocompression bonding were studied by the transmission electron microscopy. Si wafer pairs having patterned bonding frames were bonded using Al films deposited on Si or SiO{sub 2} as intermediate bonding media. A bond force of 36 or 60 kN at bonding temperatures ranging from 400–550 °C was applied for a duration of 60 min. Differences in the bonded interfaces of 200 μm wide sealing frames were investigated. It was observed that the interface had voids for bonding with 36 kN at 400 °C for Al deposited both on Si and on SiO{sub 2}. However, the dicing yield was 33% for Al on Si and 98% for Al on SiO{sub 2}, attesting for the higher quality of the latter bonds. Both a bond force of 60 kN applied at 400 °C and a bond force of 36 kN applied at 550 °C resulted in completely bonded frames with dicing yields of, respectively, 100% and 96%. A high density of long dislocations in the Al grains was observed for the 60 kN case, while the higher temperature resulted in grain boundary rotation away from the original Al-Al interface towards more stable configurations. Possible bonding mechanisms and reasons for the large difference in bonding quality of the Al films deposited on Si or SiO{sub 2} are discussed.

  18. Climate and Conflict: A Comment on Hsiang et al.s Reply to Buhaug et al

    DTIC Science & Technology

    2014-01-01

    a wide range of climatic events, from heat waves via excess rainfall to global ENSO cycles; and a wide range of spatial scales, from municipalities...again analytical consistency; The Hsiang et al. (2011) study considers a global ENSO effect whereas the studies in the valid sample investigate a local...some of the studies described in Hsiang et al. (2013). Specifically, Buhaug et al. exclude the effects of ENSO and PDSI when estimating the aggregate

  19. Thermal Modeling of Al-Al and Al-Steel Friction Stir Spot Welding

    NASA Astrophysics Data System (ADS)

    Jedrasiak, P.; Shercliff, H. R.; Reilly, A.; McShane, G. J.; Chen, Y. C.; Wang, L.; Robson, J.; Prangnell, P.

    2016-09-01

    This paper presents a finite element thermal model for similar and dissimilar alloy friction stir spot welding (FSSW). The model is calibrated and validated using instrumented lap joints in Al-Al and Al-Fe automotive sheet alloys. The model successfully predicts the thermal histories for a range of process conditions. The resulting temperature histories are used to predict the growth of intermetallic phases at the interface in Al-Fe welds. Temperature predictions were used to study the evolution of hardness of a precipitation-hardened aluminum alloy during post-weld aging after FSSW.

  20. Scientific Basis for Use of Pyrus pashia Buch.-Ham. ex D. Don. Fruit in Gastrointestinal, Respiratory and Cardiovascular Ailments

    PubMed Central

    Janbaz, Khalid Hussain; Zaeem Ahsan, Muhammad; Saqib, Fatima; Imran, Imran; Zia-Ul-Haq, Muhammad; Abid Rashid, Muhammad; Jaafar, Hawa Z. E.; Moga, Marius

    2015-01-01

    Background Pyrus pashia Buch.-Ham. ex D. Don. has been used conventionally by many communities in the Himalayan region for the management of gastrointestinal, respiratory, and vascular complications. Set against this background, this study was carried out to justify the scientific basis to validate folkloric uses of fruits of Pyrus pashia Buch.-Ham. ex D. Don. (Pp.Cr) in traditional systems of medicine. Methods The crude ethanol extract of fruits of Pyrus pashia Buch.-Ham. ex D. Don. (Pp.Cr) was tested in vitro on isolated rabbit jejunum, tracheal, and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with a PowerLab data acquisition system. Results The Pp.Cr on application (0.01–5.0 mg/ml) to isolated rabbit jejunum preparation exhibited relaxation through decrease in magnitude and frequency of spontaneous contractions. The Pp.Cr also exerted a relaxant (0.01–5.0 mg/ml) effect on K+(80 mM) induced contractions in isolated rabbit jejunum preparations and caused shifting of the Ca2+ curves (1.0–3.0 mg/ml) toward right in a manner similar to that of verapamil (3μM), possibly suggesting presence of Ca2+ channel blocking activity. Subsequently, Pp.Cr in a concentration-dependent fashion (0.01–10.0 mg/ml) caused relaxation of CCh (1μM) and K+ (80 mM) induced contractions in isolated rabbit tracheal preparations in a manner comparable to that of dicyclomine, suggesting that the observed relaxant effect is likely to be mediated through antimuscarinic and/or Ca2+ channel blocking activities. Moreover, when evaluated against isolated rabbit aortic preparations, the Pp.Cr in concentrations up to 10 mg/ml exhibited a contractile response that was found to be abolished subsequent to pretreatment of isolated tissue preparation with cyproheptadine (1μM), phentolamine (1μM), and losartan (1μM), suggesting that Pp.Cr may have some α-adrenergic, muscarinic, serotonergic, and angiotensin II activities. Conclusions The aqueous