Live imaging of rat embryos with Doppler swept-source optical coherence tomography

NASA Astrophysics Data System (ADS)

Larina, Irina V.; Furushima, Kenryo; Dickinson, Mary E.; Behringer, Richard R.; Larin, Kirill V.

2009-09-01

The rat has long been considered an excellent system to study mammalian embryonic cardiovascular physiology, but has lacked the extensive genetic tools available in the mouse to be able to create single gene mutations. However, the recent establishment of rat embryonic stem cell lines facilitates the generation of new models in the rat embryo to link changes in physiology with altered gene function to define the underlying mechanisms behind congenital cardiovascular birth defects. Along with the ability to create new rat genotypes there is a strong need for tools to analyze phenotypes with high spatial and temporal resolution. Doppler OCT has been previously used for 3-D structural analysis and blood flow imaging in other model species. We use Doppler swept-source OCT for live imaging of early postimplantation rat embryos. Structural imaging is used for 3-D reconstruction of embryo morphology and dynamic imaging of the beating heart and vessels, while Doppler-mode imaging is used to visualize blood flow. We demonstrate that Doppler swept-source OCT can provide essential information about the dynamics of early rat embryos and serve as a basis for a wide range of studies on functional evaluation of rat embryo physiology.

Live imaging of rat embryos with Doppler swept-source optical coherence tomography

PubMed Central

Larina, Irina V.; Furushima, Kenryo; Dickinson, Mary E.; Behringer, Richard R.; Larin, Kirill V.

2009-01-01

The rat has long been considered an excellent system to study mammalian embryonic cardiovascular physiology, but has lacked the extensive genetic tools available in the mouse to be able to create single gene mutations. However, the recent establishment of rat embryonic stem cell lines facilitates the generation of new models in the rat embryo to link changes in physiology with altered gene function to define the underlying mechanisms behind congenital cardiovascular birth defects. Along with the ability to create new rat genotypes there is a strong need for tools to analyze phenotypes with high spatial and temporal resolution. Doppler OCT has been previously used for 3-D structural analysis and blood flow imaging in other model species. We use Doppler swept-source OCT for live imaging of early postimplantation rat embryos. Structural imaging is used for 3-D reconstruction of embryo morphology and dynamic imaging of the beating heart and vessels, while Doppler-mode imaging is used to visualize blood flow. We demonstrate that Doppler swept-source OCT can provide essential information about the dynamics of early rat embryos and serve as a basis for a wide range of studies on functional evaluation of rat embryo physiology. PMID:19895102

Imaging of the human choroid with a 1.7 MHz A-scan rate FDML swept source OCT system

NASA Astrophysics Data System (ADS)

Gorczynska, I.; Migacz, J. V.; Jonnal, R.; Zawadzki, R. J.; Poddar, R.; Werner, J. S.

2017-02-01

We demonstrate OCT angiography (OCTA) and Doppler OCT imaging of the choroid in the eyes of two healthy volunteers and in a geographic atrophy case. We show that visualization of specific choroidal layers requires selection of appropriate OCTA methods. We investigate how imaging speed, B-scan averaging and scanning density influence visualization of various choroidal vessels. We introduce spatial power spectrum analysis of OCT en face angiographic projections as a method of quantitative analysis of choroicapillaris morphology. We explore the possibility of Doppler OCT imaging to provide information about directionality of blood flow in choroidal vessels. To achieve these goals, we have developed OCT systems utilizing an FDML laser operating at 1.7 MHz sweep rate, at 1060 nm center wavelength, and with 7.5 μm axial imaging resolution. A correlation mapping OCA method was implemented for visualization of the vessels. Joint Spectral and Time domain OCT (STdOCT) technique was used for Doppler OCT imaging.

Doppler synthetic aperture radar interferometry: a novel SAR interferometry for height mapping using ultra-narrowband waveforms

NASA Astrophysics Data System (ADS)

Yazıcı, Birsen; Son, Il-Young; Cagri Yanik, H.

2018-05-01

This paper introduces a new and novel radar interferometry based on Doppler synthetic aperture radar (Doppler-SAR) paradigm. Conventional SAR interferometry relies on wideband transmitted waveforms to obtain high range resolution. Topography of a surface is directly related to the range difference between two antennas configured at different positions. Doppler-SAR is a novel imaging modality that uses ultra-narrowband continuous waves (UNCW). It takes advantage of high resolution Doppler information provided by UNCWs to form high resolution SAR images. We introduce the theory of Doppler-SAR interferometry. We derive an interferometric phase model and develop the equations of height mapping. Unlike conventional SAR interferometry, we show that the topography of a scene is related to the difference in Doppler frequency between two antennas configured at different velocities. While the conventional SAR interferometry uses range, Doppler and Doppler due to interferometric phase in height mapping; Doppler-SAR interferometry uses Doppler, Doppler-rate and Doppler-rate due to interferometric phase in height mapping. We demonstrate our theory in numerical simulations. Doppler-SAR interferometry offers the advantages of long-range, robust, environmentally friendly operations; low-power, low-cost, lightweight systems suitable for low-payload platforms, such as micro-satellites; and passive applications using sources of opportunity transmitting UNCW.

Ultrahigh field magnetic resonance and colour Doppler real-time fusion imaging of the orbit--a hybrid tool for assessment of choroidal melanoma.

PubMed

Walter, Uwe; Niendorf, Thoralf; Graessl, Andreas; Rieger, Jan; Krüger, Paul-Christian; Langner, Sönke; Guthoff, Rudolf F; Stachs, Oliver

2014-05-01

A combination of magnetic resonance images with real-time high-resolution ultrasound known as fusion imaging may improve ophthalmologic examination. This study was undertaken to evaluate the feasibility of orbital high-field magnetic resonance and real-time colour Doppler ultrasound image fusion and navigation. This case study, performed between April and June 2013, included one healthy man (age, 47 years) and two patients (one woman, 57 years; one man, 67 years) with choroidal melanomas. All cases underwent 7.0-T magnetic resonance imaging using a custom-made ocular imaging surface coil. The Digital Imaging and Communications in Medicine volume data set was then loaded into the ultrasound system for manual registration of the live ultrasound image and fusion imaging examination. Data registration, matching and then volume navigation were feasible in all cases. Fusion imaging provided real-time imaging capabilities and high tissue contrast of choroidal tumour and optic nerve. It also allowed adding a real-time colour Doppler signal on magnetic resonance images for assessment of vasculature of tumour and retrobulbar structures. The combination of orbital high-field magnetic resonance and colour Doppler ultrasound image fusion and navigation is feasible. Multimodal fusion imaging promises to foster assessment and monitoring of choroidal melanoma and optic nerve disorders. • Orbital magnetic resonance and colour Doppler ultrasound real-time fusion imaging is feasible • Fusion imaging combines the spatial and temporal resolution advantages of each modality • Magnetic resonance and ultrasound fusion imaging improves assessment of choroidal melanoma vascularisation.

Oxygen consumption estimation with combined color doppler ultrasound and photoacoustic microscopy: a phantom study

NASA Astrophysics Data System (ADS)

Jiang, Yan; Harrison, Tyler; Forbrich, Alex; Zemp, Roger J.

2011-03-01

The metabolic rate of oxygen consumption (MRO2) quantifies tissue metabolism, which is important for diagnosis of many diseases. For a single vessel model, the MRO2 can be estimated in terms of the mean flow velocity, vessel crosssectional area, total concentration of hemoglobin (CHB), and the difference between the oxygen saturation (sO2) of blood flowing into and out of the tissue region. In this work, we would like to show the feasibility to estimate MRO2 with our combined photoacoustic and high-frequency ultrasound imaging system. This system uses a swept-scan 25-MHz ultrasound transducer with confocal dark-field laser illumination optics. A pulse-sequencer enables ultrasonic and laser pulses to be interlaced so that photoacoustic and Doppler ultrasound images are co-registered. Since the mean flow velocity can be measured by color Doppler ultrasound, the vessel cross-sectional area can be measured by power Doppler or photoacoustic imaging, and multi-wavelength photoacoustic methods can be used to estimate sO2 and CHB, all of these parameters necessary for MRO2 estimation can be provided by our system. Experiments have been performed on flow phantoms to generate co-registered color Doppler and photoacoustic images. To verify the sO2 estimation, two ink samples (red and blue) were mixed in various concentration ratios to mimic different levels of sO2, and the result shows a good match between the calculated concentration ratios and actual values.

3D ultrafast ultrasound imaging in vivo.

PubMed

Provost, Jean; Papadacci, Clement; Arango, Juan Esteban; Imbault, Marion; Fink, Mathias; Gennisson, Jean-Luc; Tanter, Mickael; Pernot, Mathieu

2014-10-07

Very high frame rate ultrasound imaging has recently allowed for the extension of the applications of echography to new fields of study such as the functional imaging of the brain, cardiac electrophysiology, and the quantitative imaging of the intrinsic mechanical properties of tumors, to name a few, non-invasively and in real time. In this study, we present the first implementation of Ultrafast Ultrasound Imaging in 3D based on the use of either diverging or plane waves emanating from a sparse virtual array located behind the probe. It achieves high contrast and resolution while maintaining imaging rates of thousands of volumes per second. A customized portable ultrasound system was developed to sample 1024 independent channels and to drive a 32  ×  32 matrix-array probe. Its ability to track in 3D transient phenomena occurring in the millisecond range within a single ultrafast acquisition was demonstrated for 3D Shear-Wave Imaging, 3D Ultrafast Doppler Imaging, and, finally, 3D Ultrafast combined Tissue and Flow Doppler Imaging. The propagation of shear waves was tracked in a phantom and used to characterize its stiffness. 3D Ultrafast Doppler was used to obtain 3D maps of Pulsed Doppler, Color Doppler, and Power Doppler quantities in a single acquisition and revealed, at thousands of volumes per second, the complex 3D flow patterns occurring in the ventricles of the human heart during an entire cardiac cycle, as well as the 3D in vivo interaction of blood flow and wall motion during the pulse wave in the carotid at the bifurcation. This study demonstrates the potential of 3D Ultrafast Ultrasound Imaging for the 3D mapping of stiffness, tissue motion, and flow in humans in vivo and promises new clinical applications of ultrasound with reduced intra--and inter-observer variability.

A multimodal imaging platform with integrated simultaneous photoacoustic microscopy, optical coherence tomography, optical Doppler tomography and fluorescence microscopy

NASA Astrophysics Data System (ADS)

Dadkhah, Arash; Zhou, Jun; Yeasmin, Nusrat; Jiao, Shuliang

2018-02-01

Various optical imaging modalities with different optical contrast mechanisms have been developed over the past years. Although most of these imaging techniques are being used in many biomedical applications and researches, integration of these techniques will allow researchers to reach the full potential of these technologies. Nevertheless, combining different imaging techniques is always challenging due to the difference in optical and hardware requirements for different imaging systems. Here, we developed a multimodal optical imaging system with the capability of providing comprehensive structural, functional and molecular information of living tissue in micrometer scale. This imaging system integrates photoacoustic microscopy (PAM), optical coherence tomography (OCT), optical Doppler tomography (ODT) and fluorescence microscopy in one platform. Optical-resolution PAM (OR-PAM) provides absorption-based imaging of biological tissues. Spectral domain OCT is able to provide structural information based on the scattering property of biological sample with no need for exogenous contrast agents. In addition, ODT is a functional extension of OCT with the capability of measurement and visualization of blood flow based on the Doppler effect. Fluorescence microscopy allows to reveal molecular information of biological tissue using autofluoresce or exogenous fluorophores. In-vivo as well as ex-vivo imaging studies demonstrated the capability of our multimodal imaging system to provide comprehensive microscopic information on biological tissues. Integrating all the aforementioned imaging modalities for simultaneous multimodal imaging has promising potential for preclinical research and clinical practice in the near future.

Proceedings of Workshop on Laser Diagnostics in Fluid Mechanics and Combustion

NASA Astrophysics Data System (ADS)

1993-10-01

Proceedings of the Workshop on Laser Diagnostics in Fluid Mechanics and Combustion are presented. Topics included are: Accuracy of Laser Doppler Anemometry; Applications of Raman-Rayleigh-LIF Diagnostics in Combustion Research; Phase Doppler Anemometer Technique Concepts and Applications; CARS; Particle Image Velocimetry; Practical Consideration in the Use and Design of Laser Velocimetry Systems in Turbomachinery Applications; Phase Doppler Measurements of Gas-Particle Flow Through a Tube Bank; Degenerate Four Wave Mixing for Shock Tunnel Studies of Supersonic Combustion; Laser Induced Photodissociation and Fluorescence (LIPF) of Sodium Species Present in Coal Combustion; 3D Holographic Measurements Inside a Spark Ignition Engine; Laser Doppler Velocimeter Measurements in Compressible Flow; Bursting in a Tornado Vortex; Quantitative Imaging of OH and Temperature Using a Single Laser Source and Single Intensified Camera; and Laser Doppler Measurements Inside an Artificial Heart Valve.

Two-dimensional multi-frequency imaging of a tumor inclusion in a homogeneous breast phantom using the harmonic motion Doppler imaging method.

PubMed

Tafreshi, Azadeh Kamali; Top, Can Barış; Gençer, Nevzat Güneri

2017-06-21

Harmonic motion microwave Doppler imaging (HMMDI) is a novel imaging modality for imaging the coupled electrical and mechanical properties of body tissues. In this paper, we used two experimental systems with different receiver configurations to obtain HMMDI images from tissue-mimicking phantoms at multiple vibration frequencies between 15 Hz and 35 Hz. In the first system, we used a spectrum analyzer to obtain the Doppler data in the frequency domain, while in the second one, we used a homodyne receiver that was designed to acquire time-domain data. The developed phantoms mimicked the elastic and dielectric properties of breast fat tissue, and included a [Formula: see text] mm cylindrical inclusion representing the tumor. A focused ultrasound probe was mechanically scanned in two lateral dimensions to obtain two-dimensional HMMDI images of the phantoms. The inclusions were resolved inside the fat phantom using both experimental setups. The image resolution increased with increasing vibration frequency. The designed receiver showed higher sensitivity than the spectrum analyzer measurements. The results also showed that time-domain data acquisition should be used to fully exploit the potential of the HMMDI method.

Two-dimensional multi-frequency imaging of a tumor inclusion in a homogeneous breast phantom using the harmonic motion Doppler imaging method

NASA Astrophysics Data System (ADS)

Kamali Tafreshi, Azadeh; Barış Top, Can; Güneri Gençer, Nevzat

2017-06-01

Harmonic motion microwave Doppler imaging (HMMDI) is a novel imaging modality for imaging the coupled electrical and mechanical properties of body tissues. In this paper, we used two experimental systems with different receiver configurations to obtain HMMDI images from tissue-mimicking phantoms at multiple vibration frequencies between 15 Hz and 35 Hz. In the first system, we used a spectrum analyzer to obtain the Doppler data in the frequency domain, while in the second one, we used a homodyne receiver that was designed to acquire time-domain data. The developed phantoms mimicked the elastic and dielectric properties of breast fat tissue, and included a 14~\\text{mm}× 9 mm cylindrical inclusion representing the tumor. A focused ultrasound probe was mechanically scanned in two lateral dimensions to obtain two-dimensional HMMDI images of the phantoms. The inclusions were resolved inside the fat phantom using both experimental setups. The image resolution increased with increasing vibration frequency. The designed receiver showed higher sensitivity than the spectrum analyzer measurements. The results also showed that time-domain data acquisition should be used to fully exploit the potential of the HMMDI method.

Translation compensation and micro-Doppler extraction for precession ballistic targets with a wideband terahertz radar

NASA Astrophysics Data System (ADS)

Yang, Qi; Deng, Bin; Wang, Hongqiang; Zhang, Ye; Qin, Yuliang

2018-01-01

Imaging, classification, and recognition techniques of ballistic targets in midcourse have always been the focus of research in the radar field for military applications. However, the high velocity translation of ballistic targets will subject range profile and Doppler to translation, slope, and fold, which are especially severe in the terahertz region. Therefore, a two-step translation compensation method based on envelope alignment is presented. The rough compensation is based on the traditional envelope alignment algorithm in inverse synthetic aperture radar imaging, and the fine compensation is supported by distance fitting. Then, a wideband imaging radar system with a carrier frequency of 0.32 THz is introduced, and an experiment on a precession missile model is carried out. After translation compensation with the method proposed in this paper, the range profile and the micro-Doppler distributions unaffected by translation are obtained, providing an important foundation for the high-resolution imaging and micro-Doppler extraction of the terahertz radar.

Spatially Resolved MR-Compatible Doppler Ultrasound: Proof of Concept for Triggering of Diagnostic Quality Cardiovascular MRI for Function and Flow Quantification at 3T.

PubMed

Crowe, Lindsey Alexandra; Manasseh, Gibran; Chmielewski, Aneta; Hachulla, Anne-Lise; Speicher, Daniel; Greiser, Andreas; Muller, Hajo; de Perrot, Thomas; Vallee, Jean-Paul; Salomir, Rares

2018-02-01

We demonstrate the use of a magnetic-resonance (MR)-compatible ultrasound (US) imaging probe using spatially resolved Doppler for diagnostic quality cardiovascular MR imaging (MRI) as an initial step toward hybrid US/MR fetal imaging. A newly developed technology for a dedicated MR-compatible phased array ultrasound-imaging probe acquired pulsed color Doppler carotid images, which were converted in near-real time to a trigger signal for cardiac cine and flow quantification MRI. Ultrasound and MR data acquired simultaneously were interference free. Conventional electrocardiogram (ECG) and the proposed spatially resolved Doppler triggering were compared in 10 healthy volunteers. A synthetic "false-triggered" image was retrospectively processed using metric optimized gating (MOG). Images were scored by expert readers, and sharpness, cardiac function and aortic flow were quantified. Four-dimensional (4-D) flow (two volunteers) showed feasibility of Doppler triggering over a long acquisition time. Imaging modalities were compatible. US probe positioning was stable and comfortable. Image quality scores and quantified sharpness were statistically equal for Doppler- and ECG-triggering (p ). ECG-, Doppler-triggered, and MOG ejection fractions were equivalent (p ), with false-triggered values significantly lower (p < 0.0005). Aortic flow showed no difference between ECG- and Doppler-triggered and MOG (p > 0.05). 4-D flow quantification gave consistent results between ECG and Doppler triggering. We report interference-free pulsed color Doppler ultrasound during MR data acquisition. Cardiovascular MRI of diagnostic quality was successfully obtained with pulsed color Doppler triggering. The hardware platform could further enable advanced free-breathing cardiac imaging. Doppler ultrasound triggering is applicable where ECG is compromised due to pathology or interference at higher magnetic fields, and where direct ECG is impossible, i.e., fetal imaging.

A Computer-Aided Diagnosis System for Measuring Carotid Artery Intima-Media Thickness (IMT) Using Quaternion Vectors.

PubMed

Kutbay, Uğurhan; Hardalaç, Fırat; Akbulut, Mehmet; Akaslan, Ünsal; Serhatlıoğlu, Selami

2016-06-01

This study aims investigating adjustable distant fuzzy c-means segmentation on carotid Doppler images, as well as quaternion-based convolution filters and saliency mapping procedures. We developed imaging software that will simplify the measurement of carotid artery intima-media thickness (IMT) on saliency mapping images. Additionally, specialists evaluated the present images and compared them with saliency mapping images. In the present research, we conducted imaging studies of 25 carotid Doppler images obtained by the Department of Cardiology at Fırat University. After implementing fuzzy c-means segmentation and quaternion-based convolution on all Doppler images, we obtained a model that can be analyzed easily by the doctors using a bottom-up saliency model. These methods were applied to 25 carotid Doppler images and then interpreted by specialists. In the present study, we used color-filtering methods to obtain carotid color images. Saliency mapping was performed on the obtained images, and the carotid artery IMT was detected and interpreted on the obtained images from both methods and the raw images are shown in Results. Also these results were investigated by using Mean Square Error (MSE) for the raw IMT images and the method which gives the best performance is the Quaternion Based Saliency Mapping (QBSM). 0,0014 and 0,000191 mm(2) MSEs were obtained for artery lumen diameters and plaque diameters in carotid arteries respectively. We found that computer-based image processing methods used on carotid Doppler could aid doctors' in their decision-making process. We developed software that could ease the process of measuring carotid IMT for cardiologists and help them to evaluate their findings.

Colour flow and motion imaging.

PubMed

Evans, D H

2010-01-01

Colour flow imaging (CFI) is an ultrasound imaging technique whereby colour-coded maps of tissue velocity are superimposed on grey-scale pulse-echo images of tissue anatomy. The most widespread use of the method is to image the movement of blood through arteries and veins, but it may also be used to image the motion of solid tissue. The production of velocity information is technically more demanding than the production of the anatomical information, partly because the target of interest is often blood, which backscatters significantly less power than solid tissues, and partly because several transmit-receive cycles are necessary for each velocity estimate. This review first describes the various components of basic CFI systems necessary to generate the velocity information and to combine it with anatomical information. It then describes a number of variations on the basic autocorrelation technique, including cross-correlation-based techniques, power Doppler, Doppler tissue imaging, and three-dimensional (3D) Doppler imaging. Finally, a number of limitations of current techniques and some potential solutions are reviewed.

Computerized Doppler Tomography and Spectrum Analysis of Carotid Artery Flow

PubMed Central

Morton, Paul; Goldman, Dave; Nichols, W. Kirt

1981-01-01

Contrast angiography remains the definitive study in the evaluation of atherosclerotic occlusive vascular disease. However, a safer technique for serial screening of symptomatic patients and for routine follow up is necessary. Computerized pulsed Doppler ultrasonic arteriography is a noninvasive technique developed by Miles6 for imaging lateral, antero-posterior and transverse sections of the carotid artery. We [ill] this system with new software and hardware to analyze the three-dimensional blood flow data. The system now provides information about the location of the occlusive process in the artery and a semi-quantitative evaluation of the degree of obstruction. In addition, we interfaced a digital signal analyzer to the system which permits spectrum analysis of the pulsed Doppler signal. This addition has allowed us to identify lesions which are not yet hemodynamically significant. ImagesFig. 2bFig. 2c

Doppler Imaging and Chemical Abundance Analysis of EK Dra: Capabilities of Small Telescopes

NASA Astrophysics Data System (ADS)

Kilicoglu, Tolgahan; Senavci, H. V.; Bahar, E.; Isik, E.; Montes, D.; Hussain, G. A. J.

2018-04-01

We investigate the chromospheric and spot activity behaviour of the young Solar-like star EK Dra via Doppler imaging and spectral synthesis methods, using mid-resolution time series spectra of the system. We also present the atmospheric parameters and detailed elemental photospheric abundances of the star. The chemical abundance pattern of EK Dra do not suggest any remarkable peculiarities except few elements. The Titanium Oxide (TiO) bandheads at 7000 - 7100 A region also give clues about the spot temperature that may be cooler than 4000 K. In addition, we also discuss the capabilities of small telescopes (40 cm in our case) and medium resolution spectrographs in terms of Doppler imaging and chemical abundance analysis.

High-frequency dual mode pulsed wave Doppler imaging for monitoring the functional regeneration of adult zebrafish hearts

PubMed Central

Kang, Bong Jin; Park, Jinhyoung; Kim, Jieun; Kim, Hyung Ham; Lee, Changyang; Hwang, Jae Youn; Lien, Ching-Ling; Shung, K. Kirk

2015-01-01

Adult zebrafish is a well-known small animal model for studying heart regeneration. Although the regeneration of scars made by resecting the ventricular apex has been visualized with histological methods, there is no adequate imaging tool for tracking the functional recovery of the damaged heart. For this reason, high-frequency Doppler echocardiography using dual mode pulsed wave Doppler, which provides both tissue Doppler (TD) and Doppler flow in a same cardiac cycle, is developed with a 30 MHz high-frequency array ultrasound imaging system. Phantom studies show that the Doppler flow mode of the dual mode is capable of measuring the flow velocity from 0.1 to 15 cm s−1 with high accuracy (p-value = 0.974 > 0.05). In the in vivo study of zebrafish, both TD and Doppler flow signals were simultaneously obtained from the zebrafish heart for the first time, and the synchronized valve motions with the blood flow signals were identified. In the longitudinal study on the zebrafish heart regeneration, the parameters for diagnosing the diastolic dysfunction, for example, E/Em < 10, E/A < 0.14 for wild-type zebrafish, were measured, and the type of diastolic dysfunction caused by the amputation was found to be similar to the restrictive filling. The diastolic function was fully recovered within four weeks post-amputation. PMID:25505135

Imaging shear wave propagation for elastic measurement using OCT Doppler variance method

NASA Astrophysics Data System (ADS)

Zhu, Jiang; Miao, Yusi; Qu, Yueqiao; Ma, Teng; Li, Rui; Du, Yongzhao; Huang, Shenghai; Shung, K. Kirk; Zhou, Qifa; Chen, Zhongping

2016-03-01

In this study, we have developed an acoustic radiation force orthogonal excitation optical coherence elastography (ARFOE-OCE) method for the visualization of the shear wave and the calculation of the shear modulus based on the OCT Doppler variance method. The vibration perpendicular to the OCT detection direction is induced by the remote acoustic radiation force (ARF) and the shear wave propagating along the OCT beam is visualized by the OCT M-scan. The homogeneous agar phantom and two-layer agar phantom are measured using the ARFOE-OCE system. The results show that the ARFOE-OCE system has the ability to measure the shear modulus beyond the OCT imaging depth. The OCT Doppler variance method, instead of the OCT Doppler phase method, is used for vibration detection without the need of high phase stability and phase wrapping correction. An M-scan instead of the B-scan for the visualization of the shear wave also simplifies the data processing.

Mobile phone based laser speckle contrast imager for assessment of skin blood flow

NASA Astrophysics Data System (ADS)

Jakovels, Dainis; Saknite, Inga; Krievina, Gita; Zaharans, Janis; Spigulis, Janis

2014-10-01

Assessment of skin blood flow is of interest for evaluation of skin viability as well as for reflection of the overall condition of the circulatory system. Laser Doppler perfusion imaging (LDPI) and laser speckle contrast imaging (LASCI) are optical techniques used for assessment of skin perfusion. However, these systems are still too expensive and bulky to be widely available. Implementation of such techniques as connection kits for mobile phones have a potential for primary diagnostics. In this work we demonstrate simple and low cost LASCI connection kit for mobile phone and its comparison to laser Doppler perfusion imager. Post-occlusive hyperemia and local thermal hyperemia tests are used to compare both techniques and to demonstrate the potential of LASCI device.

Observations of barium ion jets in the magnetosphere using Doppler imaging systems and very sensitive imaging systems using imaging photon detectors

NASA Technical Reports Server (NTRS)

Rees, D.; Conboy, J.; Heinz, W.; Heppner, J. P.

1985-01-01

Observations of four shaped charge releases from rockets launched from Alaska are described. Results demonstrate that imaging and Doppler imaging instruments, based on exploiting the imaging photon detector, provide additional insight into the motion and development of low intensity targets such as the fast ion jets produced by shaped charge releases. It is possible to trace the motion of fast ion jets to very great distances, of the order of 50,000 km, outward along the Earth's magnetic field, when the conditions are suitable for the outward (upward) motion and/or acceleration of such ion jets. It is shown that ion jets, which fade below the lower sensitivity threshold of previous instruments, do not always disappear. There is no evidence of an abrupt field-aligned shear-type acceleration.

A method to validate quantitative high-frequency power doppler ultrasound with fluorescence in vivo video microscopy.

PubMed

Pinter, Stephen Z; Kim, Dae-Ro; Hague, M Nicole; Chambers, Ann F; MacDonald, Ian C; Lacefield, James C

2014-08-01

Flow quantification with high-frequency (>20 MHz) power Doppler ultrasound can be performed objectively using the wall-filter selection curve (WFSC) method to select the cutoff velocity that yields a best-estimate color pixel density (CPD). An in vivo video microscopy system (IVVM) is combined with high-frequency power Doppler ultrasound to provide a method for validation of CPD measurements based on WFSCs in mouse testicular vessels. The ultrasound and IVVM systems are instrumented so that the mouse remains on the same imaging platform when switching between the two modalities. In vivo video microscopy provides gold-standard measurements of vascular diameter to validate power Doppler CPD estimates. Measurements in four image planes from three mice exhibit wide variation in the optimal cutoff velocity and indicate that a predetermined cutoff velocity setting can introduce significant errors in studies intended to quantify vascularity. Consistent with previously published flow-phantom data, in vivo WFSCs exhibited three characteristic regions and detectable plateaus. Selection of a cutoff velocity at the right end of the plateau yielded a CPD close to the gold-standard vascular volume fraction estimated using IVVM. An investigator can implement the WFSC method to help adapt cutoff velocity to current blood flow conditions and thereby improve the accuracy of power Doppler for quantitative microvascular imaging. Copyright © 2014 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

An Adaptive Moving Target Imaging Method for Bistatic Forward-Looking SAR Using Keystone Transform and Optimization NLCS.

PubMed

Li, Zhongyu; Wu, Junjie; Huang, Yulin; Yang, Haiguang; Yang, Jianyu

2017-01-23

Bistatic forward-looking SAR (BFSAR) is a kind of bistatic synthetic aperture radar (SAR) system that can image forward-looking terrain in the flight direction of an aircraft. Until now, BFSAR imaging theories and methods for a stationary scene have been researched thoroughly. However, for moving-target imaging with BFSAR, the non-cooperative movement of the moving target induces some new issues: (I) large and unknown range cell migration (RCM) (including range walk and high-order RCM); (II) the spatial-variances of the Doppler parameters (including the Doppler centroid and high-order Doppler) are not only unknown, but also nonlinear for different point-scatterers. In this paper, we put forward an adaptive moving-target imaging method for BFSAR. First, the large and unknown range walk is corrected by applying keystone transform over the whole received echo, and then, the relationships among the unknown high-order RCM, the nonlinear spatial-variances of the Doppler parameters, and the speed of the mover, are established. After that, using an optimization nonlinear chirp scaling (NLCS) technique, not only can the unknown high-order RCM be accurately corrected, but also the nonlinear spatial-variances of the Doppler parameters can be balanced. At last, a high-order polynomial filter is applied to compress the whole azimuth data of the moving target. Numerical simulations verify the effectiveness of the proposed method.

Noise Equalization for Ultrafast Plane Wave Microvessel Imaging.

PubMed

Song, Pengfei; Manduca, Armando; Trzasko, Joshua D; Chen, Shigao

2017-11-01

Ultrafast plane wave microvessel imaging significantly improves ultrasound Doppler sensitivity by increasing the number of Doppler ensembles that can be collected within a short period of time. The rich spatiotemporal plane wave data also enable more robust clutter filtering based on singular value decomposition. However, due to the lack of transmit focusing, plane wave microvessel imaging is very susceptible to noise. This paper was designed to: 1) study the relationship between ultrasound system noise (primarily time gain compensation induced) and microvessel blood flow signal and 2) propose an adaptive and computationally cost-effective noise equalization method that is independent of hardware or software imaging settings to improve microvessel image quality.

Development and Application of Multifunctional Optical Coherence Tomography

NASA Astrophysics Data System (ADS)

Zhi, Zhongwei

Microcirculation refers to the functions of capillaries and the neighboring lymphatic vessels. It plays a vital role in the pathophysiology of disorders in many clinical areas including cardiology, dermatology, neurology and ophthalmology, and so forth. It is crucial to develop imaging technologies that can provide both qualitative and quantitative information as to how microcirculation responds to certain injury and/or disease, and its treatment. Optical coherence tomography (OCT) is a non-invasive optical imaging technique for high-resolution cross-sectional imaging of specimens, with many applications in clinical medicine. Current state-of-the-art OCT systems operate in the Fourier domain, using either a broadband light source with a spectrometer, known as spectral domain OCT (SDOCT), or a rapidly tunable laser, known as swept source OCT (SSOCT). The current Fourier domain OCT systems have dramatically improvement in sensitivity, resolution and speed compared to time domain OCT. In addition to the improvement in the OCT system hardware, different methods for functional measurements of tissue beds have been developed and demonstrated. This includes but not limited to, i) Phase-resolved Doppler OCT for quantifying the blood flow, ii) OCT angiography for visualization of microvasculature, iii) Polarization sensitive OCT for measuring the intrinsic optical property/ birefringence of tissue, iv) spectroscopic OCT for measuring blood oxygenation, etc. Functional OCT can provide important clinical information that is not available in the typical intensity based structural OCT images. Among these functional OCT modalities, Doppler OCT and OCT angiography attract great interests as they show high capability for in vivo study of microvascular pathology. By analyzing the Doppler effect of a flowing particle on light frequency, Doppler OCT allows the quantification of the blood flow speed and blood flow rate. The most popular approach for Doppler OCT is achieved through analysis of the phase term in complex OCT signal which termed as Phase-resolved Doppler OCT. However, as limited by the phase noise and motion, Phase-resolved Doppler OCT can only be applied for relative large blood vessels, such as arterioles and venules. On the other hand, in order to visualize the microcirculation network, a number of strategies to enable better contrast of microvasculature components, which we termed OCT angiography, have been introduced during recent years. As a variation of Fourier domain OCT, optical microangiography (OMAG) is one of earliest proposed OCT angiography technique which is capable of generating 3D images of dynamic blood perfusion distribution within microcirculatory tissue beds. The OMAG algorithm works by separating the static and moving elements by high pass filtering on complex valued interferometric data after Fourier transform. Based on the conventional OMAG algorithm, we further developed ultra-high sensitive OMAG (UHS-OMAG) by switching the high-pass filtering from fast scan direction (adjacent A-lines within one B-frame) to slow scan direction (adjacent B-frames), which has a dramatically improved performance for capillary network imaging and analysis. Apart from the microvascular study with current available functional OCT for, visualization of the lymphatic system (lymph nodes and lymphatic vessels) plays a significant role in assessing patients with various malignancies and lymphedema. However, there is a lack of label-free and noninvasive method for lymphangiography. Hence, a cutting edge research to investigate the capability of OCT as a tool for non-invasive and label-free lymphangiography would be highly desired. The objective of my thesis is to develop a multiple-functional SDOCT system to image the microcirculation and quantify the several important parameters of microcirculation within microcirculatory tissue beds, and further apply it for pre-clinical research applications. The multifunctional OCT system provides modalities including structural OCT, OCT angiography, Doppler OCT and Optical lymphangiography, for multi-parametric study of tissue microstructure, blood vessel morphology, blood flow and lymphatic vessel all together. The thesis mainly focus on two parts: first, development of multi-functional OCT/optical microangiography (OMAG) system and methods for volumetric imaging of microvasculature and quantitative measurement of blood flow, and its application for pathological research in ophthalmology on rodent eye models; second, development of ultra-high resolution OCT system and algorithm for simultaneous label free imaging of blood and lymphatic vessel, and its application in wound healing study on mouse ear flap model. Objectives of my research are achieved through the following specific aims: Aim 1: Improve the sensitivity of OMAG for microvasculature imaging; perform volumetric and quantitative imaging of vasculature with combined OMAG and Phase-resolved Doppler OCT for in vivo study of vascular physiology. Aim 2: Develop high speed high resolution OCT system and method for rodent eye imaging. Apply the combined OMAG and Phase-resolved Doppler OCT approach to investigate the impact of elevated intraocular pressure on retinal, choroidal and optic nerve head blood flow in rat eye model, which aids to the better understanding of the mechanism and development of glaucoma. Aim 3: Apply the developed OCT system and ultra-high sensitive OMAG algorithm for noninvasive imaging of retinal morphology and microvasculature in obese mice, which may play an important role in early diagnosis of Diabetic retinopathy. Aim 4: Developing an ultra-high resolution SDOCT system using broadband Supercontinuum light source to achieve ultra-high resolution microvasculature imaging of biological tissue. Aim 5: Develop methods for simultaneous label free optical imaging of blood and lymphatic vessel and demonstrate its capability by monitoring the blood and lymph response to wound healing on mouse ear pinna model.

Efficient geometric rectification techniques for spectral analysis algorithm

NASA Technical Reports Server (NTRS)

Chang, C. Y.; Pang, S. S.; Curlander, J. C.

1992-01-01

The spectral analysis algorithm is a viable technique for processing synthetic aperture radar (SAR) data in near real time throughput rates by trading the image resolution. One major challenge of the spectral analysis algorithm is that the output image, often referred to as the range-Doppler image, is represented in the iso-range and iso-Doppler lines, a curved grid format. This phenomenon is known to be the fanshape effect. Therefore, resampling is required to convert the range-Doppler image into a rectangular grid format before the individual images can be overlaid together to form seamless multi-look strip imagery. An efficient algorithm for geometric rectification of the range-Doppler image is presented. The proposed algorithm, realized in two one-dimensional resampling steps, takes into consideration the fanshape phenomenon of the range-Doppler image as well as the high squint angle and updates of the cross-track and along-track Doppler parameters. No ground reference points are required.

High-Frequency Ultrasound for the Study of Early Mouse Embryonic Cardiovascular System.

PubMed

Greco, Adelaide; Coda, Anna Rita Daniela; Albanese, Sandra; Ragucci, Monica; Liuzzi, Raffaele; Auletta, Luigi; Gargiulo, Sara; Lamagna, Francesco; Salvatore, Marco; Mancini, Marcello

2015-12-01

An accurate diagnosis of congenital heart defects during fetal development is critical for interventional planning. Mice can be used to generate animal models with heart defects, and high-frequency ultrasound (HFUS) imaging enables in utero imaging of live mouse embryos. A wide range of physiological measurements is possible using Doppler-HFUS imaging; limitations of any single measurement warrant a multiparameter approach to characterize cardiovascular function. Doppler-HFUS was used to explore the embryonic (heart, aorta) and extraembryonic (umbilical blood flow) circulatory systems to create a database in normal mouse embryos between 9.5 and 16.5 days of gestation. Multivariate analyses were performed to explore correlations between gestational age and embryo echocardiographic parameters. Heart rate and peak velocity in the aorta were positively correlated with gestational time, whereas cardiac cycle length, isovolumetric relaxation time, myocardial performance index, and arterial deceleration time of the umbilical cord were negatively correlated with it. Doppler-HFUS facilitated detailed characterization of the embryonic mouse circulation and represents a useful tool for investigation of the early mouse embryonic cardiovascular system. © The Author(s) 2015.

ICIASF '85 - International Congress on Instrumentation in Aerospace Simulation Facilities, 11th, Stanford University, CA, August 26-28, 1985, Record

NASA Technical Reports Server (NTRS)

1985-01-01

Developments related to laser Doppler velocimetry are discussed, taking into account a three-component dual beam laser-Doppler-anemometer to be operated in large wind tunnels, a new optical system for three-dimensional laser-Doppler-anemometry using an argon-ion and a dye laser, and a two-component laser Doppler velocimeter by switching fringe orientation. Other topics studied are concerned with facilities, instrumentation, control, hot wire/thin film measurements, optical diagnostic techniques, signal and data processing, facilities and adaptive wall test sections, data acquisition and processing, ballistic instrument systems, dynamic testing and material deformation measurements, optical flow measurements, test techniques, force measurement systems, and holography. Attention is given to nonlinear calibration of integral wind tunnel balances, a microcomputer system for real time digitized image compression, and two phase flow diagnostics in propulsion systems.

Particle Size Measurements From the First Fundamentals of Ice Crystal Icing Physics Test in the NASA Propulsion Systems Laboratory

NASA Technical Reports Server (NTRS)

King, Michael C.; Bachalo, William; Kurek, Andrzej

2017-01-01

This paper presents particle measurements by the Artium Technologies, Inc. Phase Doppler Interferometer and High Speed Imaging instruments from the first Fundamental Ice Crystal Icing Physics test conducted in the NASA Propulsion Systems Laboratory. The work focuses on humidity sweeps at a larger and a smaller median volumetric diameter. The particle size distribution, number density, and water content measured by the Phase Doppler Interferometer and High Speed Imaging instruments from the sweeps are presented and compared. The current capability for these two instruments to measure and discriminate ICI conditions is examined.

Particle Size Measurements from the first Fundamentals of Ice Crystal Icing Physics Test in the NASA Propulsion Systems Laboratory

NASA Technical Reports Server (NTRS)

King, Michael C.; Bachalo, William; Kurek, Andrzej

2017-01-01

This presentation shows particle measurements by the Artium Technologies, Inc. Phase Doppler Interferometer and High Speed Imaging instruments from the first Fundamental Ice Crystal Icing Physics test conducted in the NASA Propulsion Systems Laboratory. The work focuses on humidity sweeps at a larger and a smaller median volumetric diameter. The particle size distribution, number density, and water content measured by the Phase Doppler Interferometer and High Speed Imaging instruments from the sweeps are presented and compared. The current capability for these two instruments to measure and discriminate ICI conditions is examined.

4-D OCT in Developmental Cardiology

NASA Astrophysics Data System (ADS)

Jenkins, Michael W.; Rollins, Andrew M.

Although strong evidence exists to suggest that altered cardiac function can lead to CHDs, few studies have investigated the influential role of cardiac function and biophysical forces on the development of the cardiovascular system due to a lack of proper in vivo imaging tools. 4-D imaging is needed to decipher the complex spatial and temporal patterns of biomechanical forces acting upon the heart. Numerous solutions over the past several years have demonstrated 4-D OCT imaging of the developing cardiovascular system. This chapter will focus on these solutions and explain their context in the evolution of 4-D OCT imaging. The first sections describe the relevant techniques (prospective gating, direct 4-D imaging, retrospective gating), while later sections focus on 4-D Doppler imaging and measurements of force implementing 4-D OCT Doppler. Finally, the techniques are summarized, and some possible future directions are discussed.

Letters: Noise Equalization for Ultrafast Plane Wave Microvessel Imaging

PubMed Central

Song, Pengfei; Manduca, Armando; Trzasko, Joshua D.

2017-01-01

Ultrafast plane wave microvessel imaging significantly improves ultrasound Doppler sensitivity by increasing the number of Doppler ensembles that can be collected within a short period of time. The rich spatiotemporal plane wave data also enables more robust clutter filtering based on singular value decomposition (SVD). However, due to the lack of transmit focusing, plane wave microvessel imaging is very susceptible to noise. This study was designed to: 1) study the relationship between ultrasound system noise (primarily time gain compensation-induced) and microvessel blood flow signal; 2) propose an adaptive and computationally cost-effective noise equalization method that is independent of hardware or software imaging settings to improve microvessel image quality. PMID:28880169

Spread-Spectrum Beamforming and Clutter Filtering for Plane-Wave Color Doppler Imaging.

PubMed

Mansour, Omar; Poepping, Tamie L; Lacefield, James C

2016-07-21

Plane-wave imaging is desirable for its ability to achieve high frame rates, allowing the capture of fast dynamic events and continuous Doppler data. In most implementations of plane-wave imaging, multiple low-resolution images from different plane wave tilt angles are compounded to form a single high-resolution image, thereby reducing the frame rate. Compounding improves the lateral beam profile in the high-resolution image, but it also acts as a low-pass filter in slow time that causes attenuation and aliasing of signals with high Doppler shifts. This paper introduces a spread-spectrum color Doppler imaging method that produces high-resolution images without the use of compounding, thereby eliminating the tradeoff between beam quality, maximum unaliased Doppler frequency, and frame rate. The method uses a long, random sequence of transmit angles rather than a linear sweep of plane wave directions. The random angle sequence randomizes the phase of off-focus (clutter) signals, thereby spreading the clutter power in the Doppler spectrum, while keeping the spectrum of the in-focus signal intact. The ensemble of randomly tilted low-resolution frames also acts as the Doppler ensemble, so it can be much longer than a conventional linear sweep, thereby improving beam formation while also making the slow-time Doppler sampling frequency equal to the pulse repetition frequency. Experiments performed using a carotid artery phantom with constant flow demonstrate that the spread-spectrum method more accurately measures the parabolic flow profile of the vessel and outperforms conventional plane-wave Doppler in both contrast resolution and estimation of high flow velocities. The spread-spectrum method is expected to be valuable for Doppler applications that require measurement of high velocities at high frame rates.

Real-time and interactive virtual Doppler ultrasound

NASA Astrophysics Data System (ADS)

Hirji, Samira; Downey, Donal B.; Holdsworth, David W.; Steinman, David A.

2005-04-01

This paper describes our "virtual" Doppler ultrasound (DUS) system, in which colour DUS (CDUS) images and DUS spectrograms are generated on-the-fly and displayed in real-time in response to position and orientation cues provided by a magnetically tracked handheld probe. As the presence of complex flow often confounds the interpretation of Doppler ultrasound data, this system will serve to be a fundamental tool for training sonographers and gaining insight into the relationship between ambiguous DUS images and complex blood flow dynamics. Recently, we demonstrated that DUS spectra could be realistically simulated in real-time, by coupling a semi-empirical model of the DUS physics to a 3-D computational fluid dynamics (CFD) model of a clinically relevant flow field. Our system is an evolution of this approach where a motion-tracking device is used to continuously update the origin and orientation of a slice passing through a CFD model of a stenosed carotid bifurcation. After calibrating our CFD model onto a physical representation of a human neck, virtual CDUS images from an instantaneous slice are then displayed at a rate of approximately 15 Hz by simulating, on-the-fly, an array of DUS spectra and colour coding the resulting spectral mean velocity using a traditional Doppler colour scale. Mimicking a clinical examination, the operator can freeze the CDUS image on-screen, and a spectrogram corresponding to the selected sample volume location is rendered at a higher frame rate of at least 30 Hz. All this is achieved using an inexpensive desktop workstation and commodity graphics card.

High-sensitivity detection and monitoring of microcirculation using cutaneous and catheter probes for Doppler optical coherence tomography

NASA Astrophysics Data System (ADS)

Yang, Victor X.; Gordon, M. L.; Qi, B.; Yue, E. Seng; Tang, S.; Bisland, Stuart K.; Pekar, J.; Lo, S.; Marcon, Norman E.; Wilson, B.; Vitkin, Alex

2003-07-01

Background: Currently clinical Doppler ultrasound cannot detect microvascular blood flow and it is difficult to provide depth discrimination using laser Doppler flowmetry. Doppler optical coherence tomography (DOCT) is a novel technique for noninvasive subsurface imaging of microcirculation and tissue structure. Aims: To design handheld and catheter-based DOCT probes for clinical cutaneous and endoscopic imaging. To develop signal processing techniques for real-time detection and quantification of microvascular blood flow. Methods: A DOCT system, with interchangeable cutaneous and catheter probes, was developed. The axial spatial resolution was 10 μm, and the velocity resolution was 20 μm/s, using a 1300 nm broadband infrared light. The system achieved real-time imaging with frame rates up to 32 Hz at 512 x 256 pixels per frame. We used the system to detect microcirculation in human skin and rat esophagus, and to monitor microvascular responses to photodynamic therapy (PDT) in a rat tumor model. Results: We present experimental results from in vivo DOCT imaging of microcirculation in human skin arterio-venous malformations (AVM), normal rat esophagus, and a rat gliosarcoma PDT model. In the PDT model, we followed microvascular responses to PDT and observed differences in the microcirculation during and after therapy, which can have important implications for PDT dosimetry and treatment optimization. Conclusions: To our knowledge, this is the first demonstration of endoscopic catheter-based DOCT detection of microcirculation in vivo. In addition, AVM can be detected using handheld cutaneous DOCT probes under clinical settings. DOCT may serve as a real-time monitoring tool for PDT dosimetry, especially for vascular targeting photosensitizers.

Internet (WWW) based system of ultrasonic image processing tools for remote image analysis.

PubMed

Zeng, Hong; Fei, Ding-Yu; Fu, Cai-Ting; Kraft, Kenneth A

2003-07-01

Ultrasonic Doppler color imaging can provide anatomic information and simultaneously render flow information within blood vessels for diagnostic purpose. Many researchers are currently developing ultrasound image processing algorithms in order to provide physicians with accurate clinical parameters from the images. Because researchers use a variety of computer languages and work on different computer platforms to implement their algorithms, it is difficult for other researchers and physicians to access those programs. A system has been developed using World Wide Web (WWW) technologies and HTTP communication protocols to publish our ultrasonic Angle Independent Doppler Color Image (AIDCI) processing algorithm and several general measurement tools on the Internet, where authorized researchers and physicians can easily access the program using web browsers to carry out remote analysis of their local ultrasonic images or images provided from the database. In order to overcome potential incompatibility between programs and users' computer platforms, ActiveX technology was used in this project. The technique developed may also be used for other research fields.

Vibration amplitude sonoelastography lesion imaging using low-frequency audible vibration

NASA Astrophysics Data System (ADS)

Taylor, Lawrence; Parker, Kevin

2003-04-01

Sonoelastography or vibration amplitude imaging is an ultrasound imaging technique in which low-amplitude, low-frequency shear waves, less than 0.1-mm displacement and 1-kHz frequency, are propagated deep into tissue, while real time Doppler techniques are used to image the resulting vibration pattern. Finite-element studies and experiments on tissue-mimicking phantoms verify that a discrete hard inhomogeneity present within a larger region of soft tissue will cause a decrease in the vibration field at its location. This forms the basis for tumor detection using sonoelastography. Real time relative imaging of the vibration field is possible because a vibrating particle will phase modulate an ultrasound signal. The particle's amplitude is directly proportional to the spectral spread of the reflected Doppler echo. Real time estimation of the variance of the Doppler power spectrum at each pixel allows the vibration field to be imaged. Results are shown for phantom lesions, thermal lesions, and 3-D in vitro and 2-D in vivo prostate cancer. MRI and whole mount histology is used to validate the system accuracy.

Closed loop tracked Doppler optical coherence tomography based heart monitor for the Drosophila melanogaster larvae.

PubMed

Zurauskas, Mantas; Bradu, Adrian; Ferguson, Daniel R; Hammer, Daniel X; Podoleanu, Adrian

2016-03-01

This paper presents a novel instrument for biosciences, useful for studies of moving embryos. A dual sequential imaging/measurement channel is assembled via a closed-loop tracking architecture. The dual channel system can operate in two regimes: (i) single-point Doppler signal monitoring or (ii) fast 3-D swept source OCT imaging. The system is demonstrated for characterizing cardiac dynamics in Drosophila melanogaster larva. Closed loop tracking enables long term in vivo monitoring of the larvae heart without anesthetic or physical restraint. Such an instrument can be used to measure subtle variations in the cardiac behavior otherwise obscured by the larvae movements. A fruit fly larva (top) was continuously tracked for continuous remote monitoring. A heartbeat trace of freely moving larva (bottom) was obtained by a low coherence interferometry based doppler sensing technique. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Improved cardiac motion detection from ultrasound images using TDIOF: a combined B-mode/ tissue Doppler approach

NASA Astrophysics Data System (ADS)

Tavakoli, Vahid; Stoddard, Marcus F.; Amini, Amir A.

2013-03-01

Quantitative motion analysis of echocardiographic images helps clinicians with the diagnosis and therapy of patients suffering from cardiac disease. Quantitative analysis is usually based on TDI (Tissue Doppler Imaging) or speckle tracking. These methods are based on two independent techniques - the Doppler Effect and image registration, respectively. In order to increase the accuracy of the speckle tracking technique and cope with the angle dependency of TDI, herein, a combined approach dubbed TDIOF (Tissue Doppler Imaging Optical Flow) is proposed. TDIOF is formulated based on the combination of B-mode and Doppler energy terms in an optical flow framework and minimized using algebraic equations. In this paper, we report on validations with simulated, physical cardiac phantom, and in-vivo patient data. It is shown that the additional Doppler term is able to increase the accuracy of speckle tracking, the basis for several commercially available echocardiography analysis techniques.

Application of the multiple PRF technique to resolve Doppler centroid estimation ambiguity for spaceborne SAR

NASA Technical Reports Server (NTRS)

Chang, C. Y.; Curlander, J. C.

1992-01-01

Estimation of the Doppler centroid ambiguity is a necessary element of the signal processing for SAR systems with large antenna pointing errors. Without proper resolution of the Doppler centroid estimation (DCE) ambiguity, the image quality will be degraded in the system impulse response function and the geometric fidelity. Two techniques for resolution of DCE ambiguity for the spaceborne SAR are presented; they include a brief review of the range cross-correlation technique and presentation of a new technique using multiple pulse repetition frequencies (PRFs). For SAR systems, where other performance factors control selection of the PRF's, an algorithm is devised to resolve the ambiguity that uses PRF's of arbitrary numerical values. The performance of this multiple PRF technique is analyzed based on a statistical error model. An example is presented that demonstrates for the Shuttle Imaging Radar-C (SIR-C) C-band SAR, the probability of correct ambiguity resolution is higher than 95 percent for antenna attitude errors as large as 3 deg.

Automated assessment of blood flow in developing embryonic hearts by extending dynamic range of Doppler OCT using a MHz FDML swept laser source (Conference Presentation)

NASA Astrophysics Data System (ADS)

Elahi, Sahar; Thrane, Lars; Rollins, Andrew M.; Jenkins, Michael W.

2017-02-01

Altered hemodynamics in developing embryonic hearts lead to congenital heart diseases, motivating close monitoring of blood flow over several stages of development. Doppler OCT can assess blood flow in tubular hearts, but the maximum velocity increases drastically during the period of cardiac cushion (valve precursors) formation. Therefore, the limited dynamic range of Doppler OCT velocity measurement makes it difficult to conduct longitudinal studies without phase wrapping at high velocities or loss of sensitivity to slow velocities. We have built a high-speed OCT system using an FDML laser (Optores GmbH, Germany) at a sweep rate of 1.68 MHz (axial resolution - 12 μm, sensitivity - 105 dB, phase stability - 17 mrad). The speed of this OCT system allows us to acquire high-density B-scans to obtain an extended velocity dynamic range without sacrificing the frame rate. The extended dynamic range within a frame is achieved by varying the A-scan interval at which the phase difference is found, enabling detection of velocities ranging from tens of microns per second to hundreds of mm per second. The extra lines in a frame can also be utilized to improve the structural and Doppler images via complex averaging. In structural images where presence of blood causes additional scattering, complex averaging helps retrieve features located deeper in the tissue. Moreover, high-density frames can be registered to 4D volumes to determine the orthogonal direction of flow and calculate shear stress. In conclusion, our high-speed OCT system will enable automated Doppler imaging of embryonic hearts in cohort studies.

Comparison of the severity of lower extremity arterial disease in smokers and patients with diabetes using a novel duplex Doppler scoring system.

PubMed

Hiremath, Rudresh; Gowda, Goutham; Ibrahim, Jebin; Reddy, Harish T; Chodiboina, Haritha; Shah, Rushit

2017-07-01

The aim of this study was to validate the diagnostic feasibility of a novel scoring system of peripheral arterial disease (PAD) in smokers and patients with diabetes depending on duplex Doppler sonographic features. Patients presenting with the symptomatology of PAD were divided into three groups: diabetes only, smoking only, and smokers with diabetes. The patients were clinically examined, a clinical severity score was obtained, and the subjects were categorized into the three extrapolated categories of mild, moderate, and severe. All 106 subjects also underwent a thorough duplex Doppler examination, and various aspects of PAD were assessed and tabulated. These components were used to create a novel duplex Doppler scoring system. Depending on the scores obtained, each individual was categorized as having mild, moderate, or severe illness. The Cohen kappa value was used to assess interobserver agreement between the two scoring systems. Interobserver agreement between the traditional Rutherford clinical scoring system and the newly invented duplex Doppler scoring system showed a kappa value of 0.83, indicating significant agreement between the two scoring systems (P<0.001). Duplex Doppler imaging is an effective screening investigation for lower extremity arterial disease, as it not only helps in its diagnosis, but also in the staging and grading of the disease, providing information that can be utilized for future management and treatment planning.

The first Doppler images of the eclipsing binary SZ Piscium

NASA Astrophysics Data System (ADS)

Xiang, Yue; Gu, Shenghong; Cameron, A. Collier; Barnes, J. R.; Zhang, Liyun

2016-02-01

We present the first Doppler images of the active eclipsing binary system SZ Psc, based on the high-resolution spectral data sets obtained in 2004 November and 2006 September-December. The least-squares deconvolution technique was applied to derive high signal-to-noise profiles from the observed spectra of SZ Psc. Absorption features contributed by a third component of the system were detected in the LSD profiles at all observed phases. We estimated the mass and period of the third component to be about 0.9 M⊙ and 1283 ± 10 d, respectively. After removing the contribution of the third body from the least-squares deconvolved profiles, we derived the surface maps of SZ Psc. The resulting Doppler images indicate significant star-spot activities on the surface of the K subgiant component. The distributions of star-spots are more complex than that revealed by previous photometric studies. The cooler K component exhibited pronounced high-latitude spots as well as numerous low- and intermediate-latitude spot groups during the entire observing seasons, but did not show any large, stable polar cap, different from many other active RS CVn-type binaries.

Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review

PubMed Central

Sharif, S.A.; Taydas, E.; Mazhar, A.; Rahimian, R.; Kelly, K.M.; Choi, B.; Durkin, A.J.

2012-01-01

Port wine stain (PWS) birthmarks are one class of benign congenital vascular malformation. Laser therapy is the most successful treatment modality of PWS. Unfortunately, this approach has limited efficacy, with only 10% of patients experiencing complete blanching of the PWS. To address this problem, several research groups have developed technologies and methods designed to study treatment outcome and improve treatment efficacy. This paper reviews seven optical imaging techniques currently in use or under development to assess treatment efficacy, focusing on: Reflectance spectrophotometers/tristimulus colorimeters, Laser Doppler flowmetry (LDF) and Laser Doppler imaging (LDI), Cross-polarized diffuse reflectance color imaging system (CDR), Reflectance Confocal Microscopy (RCM), Optical Coherence Tomography (OCT), Spatial Frequency Domain Imaging (SFDI), and Laser Speckle Imaging (LSI). PMID:22804872

Complex regression Doppler optical coherence tomography

NASA Astrophysics Data System (ADS)

Elahi, Sahar; Gu, Shi; Thrane, Lars; Rollins, Andrew M.; Jenkins, Michael W.

2018-04-01

We introduce a new method to measure Doppler shifts more accurately and extend the dynamic range of Doppler optical coherence tomography (OCT). The two-point estimate of the conventional Doppler method is replaced with a regression that is applied to high-density B-scans in polar coordinates. We built a high-speed OCT system using a 1.68-MHz Fourier domain mode locked laser to acquire high-density B-scans (16,000 A-lines) at high enough frame rates (˜100 fps) to accurately capture the dynamics of the beating embryonic heart. Flow phantom experiments confirm that the complex regression lowers the minimum detectable velocity from 12.25 mm / s to 374 μm / s, whereas the maximum velocity of 400 mm / s is measured without phase wrapping. Complex regression Doppler OCT also demonstrates higher accuracy and precision compared with the conventional method, particularly when signal-to-noise ratio is low. The extended dynamic range allows monitoring of blood flow over several stages of development in embryos without adjusting the imaging parameters. In addition, applying complex averaging recovers hidden features in structural images.

Vector Doppler: spatial sampling analysis and presentation techniques for real-time systems

NASA Astrophysics Data System (ADS)

Capineri, Lorenzo; Scabia, Marco; Masotti, Leonardo F.

2001-05-01

The aim of the vector Doppler (VD) technique is the quantitative reconstruction of a velocity field independently of the ultrasonic probe axis to flow angle. In particular vector Doppler is interesting for studying vascular pathologies related to complex blood flow conditions. Clinical applications require a real-time operating mode and the capability to perform Doppler measurements over a defined volume. The combination of these two characteristics produces a real-time vector velocity map. In previous works the authors investigated the theory of pulsed wave (PW) vector Doppler and developed an experimental system capable of producing off-line 3D vector velocity maps. Afterwards, for producing dynamic velocity vector maps, we realized a new 2D vector Doppler system based on a modified commercial echograph. The measurement and presentation of a vector velocity field requires a correct spatial sampling that must satisfy the Shannon criterion. In this work we tackled this problem, establishing a relationship between sampling steps and scanning system characteristics. Another problem posed by the vector Doppler technique is the data representation in real-time that should be easy to interpret for the physician. With this in mine we attempted a multimedia solution that uses both interpolated images and sound to represent the information of the measured vector velocity map. These presentation techniques were experimented for real-time scanning on flow phantoms and preliminary measurements in vivo on a human carotid artery.

B-Flow Imaging in Lower Limb Peripheral Arterial Disease and Bypass Graft Ultrasonography.

PubMed

D'Abate, Fabrizio; Ramachandran, Veni; Young, Mark A; Farrah, John; Ahmed, Mudasar H; Jones, Keith; Hinchliffe, Robert J

2016-09-01

Doppler ultrasonography plays a key role in the diagnosis of peripheral arterial disease, but is often limited by pitfalls that may be overcome by B-flow imaging. Thus far, there is little information on B-flow imaging for the assessment of peripheral arterial disease and bypass grafts in lower limbs. This article describes the authors' early experience with B-flow in the lower extremities. Sixty patients were included among a large cohort of patients routinely referred to the vascular laboratory for peripheral arterial disease and bypass graft assessments. Two experienced vascular sonographers performed all scans, comparing color Doppler ultrasonography with B-flow imaging. All scans were performed using a combination of the 9 L linear and C2-9 curvilinear transducers with the LOGIQ E9 system (GE Healthcare, Waukesha, WI, USA). Our experience indicates that this relatively unexplored technology has the potential to significantly improve peripheral blood flow evaluation. Nevertheless, B-flow imaging is not exempt from limitations and should be considered complementary to color Doppler ultrasonography. Copyright © 2016 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

Power Doppler evaluation of joint effusions: investigation in a rabbit model.

PubMed

Strouse, P J; DiPietro, M A; Teo, E L; Doi, K; Chrisp, C E

1999-08-01

To study the power Doppler findings of septic arthritis and noninfectious synovitis in an animal model. The right knees of 10 rabbits were inoculated with an aqueous suspension of Staphylococcus aureus. The right knees of 5 rabbits were injected with talc suspension. The right knees of 5 rabbits were injected with saline. All 20 left knees were injected with saline. Serial power Doppler images were obtained using constant-imaging parameters. Images were reviewed by blinded observers who assessed for increased power Doppler signal. All 10 knees inoculated with S. aureus developed septic arthritis. Each infected rabbit knee demonstrated increased signal on power Doppler on at least one examination, ranging from 1-6 days after inoculation. Only 23 of 45 examinations of infected knees were unequivocally positive by power Doppler on examinations performed 1 to 6 days after inoculation. No knee with talc synovitis demonstrated increased power Doppler signal. No control knee demonstrated increased power Doppler signal. Increased power Doppler signal may be seen with septic arthritis; however, its intensity and timing may vary from subject to subject. A normal power Doppler examination does not exclude septic arthritis.

Doppler Imaging of Exoplanets and Brown Dwarfs

NASA Astrophysics Data System (ADS)

Crossfield, I.; Biller, B.; Schlieder, J.; Deacon, N.; Bonnefoy, M.; Homeier, D.; Allard, F.; Buenzli, E.; Henning, T.; Brandner, W.; Goldman, Bertr; Kopytova, T.

2014-03-01

Doppler Imaging produces 2D global maps. When applied to cool planets or more massive brown dwarfs, it can map atmospheric features and track global weather patterns. The first substellar map, of the 2pc-distant brown dwarf Luhman 16B (Crossfeld et al. 2014), revealed patchy regions of thin & thick clouds. Here, I investigate the feasibility of future Doppler Imaging of additional objects. Searching the literature, I find that all 3 of P, v sin i, and variability are published for 22 brown dwarfs. At least one datum exists for 333 targets. The sample is very incomplete below ~L5; we need more surveys to find the best targets for Doppler Imaging! I estimate limiting magnitudes for Doppler Imaging with various hi-resolution near-infrared spectrographs. Only a handful of objects - at the M/L and L/T transitions - can be mapped with current tools. Large telescopes such as TMT and GMT will allow Doppler Imaging of many dozens of brown dwarfs and the brightest exoplanets. More targets beyond type L5 likely remain to be found. Future observations will let us probe the global atmospheric dynamics of many diverse objects.

Right Ventricular Tissue Doppler in Space Flight

NASA Technical Reports Server (NTRS)

Garcia, Kathleen M.; Hamilton, Douglas R.; Sargsyan, Ashot E.; Ebert, Douglas; Martin, David S.; Barratt, Michael R.; Martin, David S.; Bogomolov, Valery V.; Dulchavsky, Scott A.; Duncan, J. Michael

2010-01-01

The presentation slides review normal physiology of the right ventricle in space, general physiology of the right ventricle; difficulties in imaging the heart in space, imaging methods, tissue Doppler spectrum, right ventricle tissue Doppler, and Rt Tei Index.

Three-dimensional vascular imaging of proliferative diabetic retinopathy by Doppler optical coherence tomography.

PubMed

Miura, Masahiro; Hong, Young-Joo; Yasuno, Yoshiaki; Muramatsu, Daisuke; Iwasaki, Takuya; Goto, Hiroshi

2015-03-01

To evaluate the 3-dimensional architecture of neovascularization in proliferative diabetic retinopathy using Doppler optical coherence tomography (OCT). Prospective, nonrandomized clinical trial. Seventeen eyes of 14 patients with proliferative diabetic retinopathy were prospectively studied. Prototype Doppler OCT was used to evaluate the 3-dimensional vascular architecture at vitreoretinal adhesions. Proliferative membranes were detected in all eyes with proliferative diabetic retinopathy by standard OCT images. Doppler OCT images detected blood flow by neovascularization of the disc in 12 eyes and neovascularization elsewhere in 11 eyes. Doppler OCT images showed the 3-dimensional extent of new vessels at various stages of neovascularization, and the extent of new vessels could be clearly confirmed at vitreoretinal adhesions. Doppler OCT is useful for the detection and evaluation of the 3-dimensional vascular structure of neovascularization, and can assist in the noninvasive assessment of proliferative diabetic retinopathy. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Comparison of transrectal photoacoustic, Doppler, and magnetic resonance imaging for prostate cancer detection

NASA Astrophysics Data System (ADS)

Ishihara, Miya; Horiguchi, Akio; Shinmoto, Hiroshi; Tsuda, Hitoshi; Irisawa, Kaku; Wada, Takatsugu; Asano, Tomohiko

2016-03-01

Transrectal ultrasonography (TRUS) is the most popular imaging modality for diagnosing and treating prostate cancer. TRUS-guided prostate biopsy is mandatory for the histological diagnosis of patients with elevated serum prostatespecific antigen (PSA), but its diagnostic accuracy is not satisfactory due to TRUS's low resolution. As a result, a considerable number of patients are required to undergo an unnecessary repeated biopsy. Photoacoustic imaging (PAI) can be used to provide microvascular network imaging using hemoglobin as an intrinsic, optical absorption molecule. We developed an original TRUS-type PAI probe consisting of a micro-convex array transducer with an optical illumination system to provide superimposed PAI and ultrasound images. TRUS-type PAI has the advantage of having much higher resolution and greater contrast than does Doppler TRUS. The purpose of this study was to demonstrate the clinical feasibility of the transrectal PAI system. We performed a clinical trial to compare the image of the cancerous area obtained by transrectal PAI with that obtained by TRUS Doppler during prostate biopsy. The obtained prostate biopsy cores were stained with anti-CD34 antibodies to provide a microvascular distribution map. We also confirmed its consistency with PAI and pre-biopsy MRI findings. Our study demonstrated that transrectal identification of tumor angiogenesis under superimposed photoacoustic and ultrasound images was easier than that under TRUS alone. We recognized a consistent relationship between PAI and MRI findings in most cases. However, there were no correspondences in some cases.

Comparison of laser Doppler and laser speckle contrast imaging using a concurrent processing system

NASA Astrophysics Data System (ADS)

Sun, Shen; Hayes-Gill, Barrie R.; He, Diwei; Zhu, Yiqun; Huynh, Nam T.; Morgan, Stephen P.

2016-08-01

Full field laser Doppler imaging (LDI) and single exposure laser speckle contrast imaging (LSCI) are directly compared using a novel instrument which can concurrently image blood flow using both LDI and LSCI signal processing. Incorporating a commercial CMOS camera chip and a field programmable gate array (FPGA) the flow images of LDI and the contrast maps of LSCI are simultaneously processed by utilizing the same detected optical signals. The comparison was carried out by imaging a rotating diffuser. LDI has a linear response to the velocity. In contrast, LSCI is exposure time dependent and does not provide a linear response in the presence of static speckle. It is also demonstrated that the relationship between LDI and LSCI can be related through a power law which depends on the exposure time of LSCI.

High-frequency ultrasound Doppler system for biomedical applications with a 30-MHz linear array.

PubMed

Xu, Xiaochen; Sun, Lei; Cannata, Jonathan M; Yen, Jesse T; Shung, K Kirk

2008-04-01

In this paper, we report the development of the first high-frequency (HF) pulsed-wave Doppler system using a 30-MHz linear array transducer to assess the cardiovascular functions in small animals. This array-based pulsed-wave Doppler system included a 16-channel HF analog beamformer, a HF pulsed-wave Doppler module, timing circuits, HF bipolar pulsers and analog front ends. The beamformed echoes acquired by the 16-channel analog beamformer were fed directly to the HF pulsed-wave Doppler module. Then the in-phase and quadrature-phase (IQ) audio Doppler signals were digitized by either a sound card or a Gage digitizer and stored in a personal computer. The Doppler spectrogram was displayed on a personal computer in real time. The two-way beamwidths were determined to be 160 microm to 320 microm when the array was electronically focused at different focal points at depths from 5 to 10 mm. A micro-flow phantom, consisting of a polyimide tube with an inner diameter of 127 microm and the wire phantom were used to evaluate and calibrate the system. The results show that the system is capable of detecting motion velocity of the wire phantom as low as 0.1 mm/s, and detecting blood-mimicking flow velocity in the 127-microm tube lower than 7 mm/s. The system was subsequently used to measure the blood flow in vivo in two mouse abdominal superficial vessels, with diameters of approximately 200 microm, and a mouse aorta close to the heart. These results demonstrated that this system may become an indispensable part of the current HF array-based imaging systems for small animal studies.

Power M-mode Doppler (PMD) for observing cerebral blood flow and tracking emboli.

PubMed

Moehring, Mark A; Spencer, Merrill P

2002-01-01

Difficulties in location of transcranial ultrasound (US) windows and blood flow in cerebral vessels, and unambiguous detection of microemboli, have limited expansion of transcranial Doppler US. We developed a new transcranial Doppler modality, power M-mode Doppler (PMD), for addressing these issues. A 2-MHz digital Doppler (Spencer Technologies TCD100M) having 33 sample gates placed with 2-mm spacing was configured to display Doppler signal power, colored red and blue for directionality, in an M-mode format. The spectrogram from a user-selected depth was displayed simultaneously. This system was then explored on healthy subjects and patients presenting with varying cerebrovascular pathology. PMD facilitated window location and alignment of the US beam to view blood flow from multiple vessels simultaneously, without sound or spectral clues. Microemboli appeared as characteristic sloping high-power tracks in the PMD image. Power M-mode Doppler is a new paradigm facilitating vessel location, diagnosis, monitoring and microembolus detection.

A new fringeline-tracking approach for color Doppler ultrasound imaging phase unwrapping

NASA Astrophysics Data System (ADS)

Saad, Ashraf A.; Shapiro, Linda G.

2008-03-01

Color Doppler ultrasound imaging is a powerful non-invasive diagnostic tool for many clinical applications that involve examining the anatomy and hemodynamics of human blood vessels. These clinical applications include cardio-vascular diseases, obstetrics, and abdominal diseases. Since its commercial introduction in the early eighties, color Doppler ultrasound imaging has been used mainly as a qualitative tool with very little attempts to quantify its images. Many imaging artifacts hinder the quantification of the color Doppler images, the most important of which is the aliasing artifact that distorts the blood flow velocities measured by the color Doppler technique. In this work we will address the color Doppler aliasing problem and present a recovery methodology for the true flow velocities from the aliased ones. The problem is formulated as a 2D phase-unwrapping problem, which is a well-defined problem with solid theoretical foundations for other imaging domains, including synthetic aperture radar and magnetic resonance imaging. This paper documents the need for a phase unwrapping algorithm for use in color Doppler ultrasound image analysis. It describes a new phase-unwrapping algorithm that relies on the recently developed cutline detection approaches. The algorithm is novel in its use of heuristic information provided by the ultrasound imaging modality to guide the phase unwrapping process. Experiments have been performed on both in-vitro flow-phantom data and in-vivo human blood flow data. Both data types were acquired under a controlled acquisition protocol developed to minimize the distortion of the color Doppler data and hence to simplify the phase-unwrapping task. In addition to the qualitative assessment of the results, a quantitative assessment approach was developed to measure the success of the results. The results of our new algorithm have been compared on ultrasound data to those from other well-known algorithms, and it outperforms all of them.

Automated assessment of noninvasive filling pressure using color Doppler M-mode echocardiography

NASA Technical Reports Server (NTRS)

Greenberg, N. L.; Firstenberg, M. S.; Cardon, L. A.; Zuckerman, J.; Levine, B. D.; Garcia, M. J.; Thomas, J. D.

2001-01-01

Assessment of left ventricular filling pressure usually requires invasive hemodynamic monitoring to follow the progression of disease or the response to therapy. Previous investigations have shown accurate estimation of wedge pressure using noninvasive Doppler information obtained from the ratio of the wave propagation slope from color M-mode (CMM) images and the peak early diastolic filling velocity from transmitral Doppler images. This study reports an automated algorithm that derives an estimate of wedge pressure based on the spatiotemporal velocity distribution available from digital CMM Doppler images of LV filling.

Observations of winds with an incoherent lidar detector

NASA Technical Reports Server (NTRS)

Abreu, Vincent J.; Barnes, John E.; Hays, Paul B.

1992-01-01

A Fabry-Perot interferometer and image-plane detector system to be used as a receiver for a Doppler lidar have been developed. This system incorporates the latest technology in multichannel detectors, and it is an important step toward the development of operational wind profiler systems for the atmosphere. The instrumentation includes a stable high-resolution optically contacted plane etalon and a multiring anode detector to scan the image plane of the Fabry-Perot interferometer spatially. The high wavelength resolution provided by the interferometer permits the aerosol and molecular components of the backscattered signal to be distinguished, and the Doppler shift of either component can then be used to determine the wind altitude profile. The receiver performance has been tested by measuring the wind profile in the boundary layer. The Fabry-Perot interferometer and image-plane detector characteristics are described and sample measurements are presented. The potential of the system as a wind profiler in the troposphere, the stratosphere, and the mesosphere is also considered.

Blood flow velocity measurement by endovascular Doppler optical coherence tomography

NASA Astrophysics Data System (ADS)

Sun, Cuiru; Nolte, Felix; Vuong, Barry; Cheng, Kyle H. Y.; Lee, Kenneth K. C.; Standish, Beau A.; Courtney, Brian; Marotta, Tom R.; Yang, Victor X. D.

2013-03-01

Blood flow velocity and volumetric flow measurements are important parameters for assessment of the severity of stenosis and the outcome of interventional therapy. However, feasibility of intravascular flow measurement using a rotational catheter based phase resolved Doppler optical coherence tomography (DOCT) is difficult. Motion artefacts induced by the rotating optical imaging catheter, and the radially dependent noise background of measured Doppler signals are the main challenges encountered. In this study, a custom-made data acquisition system and developed algorithms to remove non-uniform rotational distortion (NURD) induced phase shift artefact by tracking the phase shift observed on catheter sheath. The flow velocity is calculated from Doppler shift obtained by Kasai autocorrelation after motion artefact removal. Blood flow velocity profiles in porcine carotid arteries in vivo were obtained at 100 frames/s with 500 A-lines/frame and DOCT images were taken at 20 frames/s with 2500 A-lines/frame. Time-varying velocity profiles were obtained at an artery branch. Furthermore, the identification of a vein adjacent to the catheterized vessel based on the color Doppler signal was also observed. The absolute measurement of intravascular flow using a rotating fiber catheter can provide insights to different stages of interventional treatment of stenosis in carotid artery.

Spotlight-Mode Synthetic Aperture Radar Processing for High-Resolution Lunar Mapping

NASA Technical Reports Server (NTRS)

Harcke, Leif; Weintraub, Lawrence; Yun, Sang-Ho; Dickinson, Richard; Gurrola, Eric; Hensley, Scott; Marechal, Nicholas

2010-01-01

During the 2008-2009 year, the Goldstone Solar System Radar was upgraded to support radar mapping of the lunar poles at 4 m resolution. The finer resolution of the new system and the accompanying migration through resolution cells called for spotlight, rather than delay-Doppler, imaging techniques. A new pre-processing system supports fast-time Doppler removal and motion compensation to a point. Two spotlight imaging techniques which compensate for phase errors due to i) out of focus-plane motion of the radar and ii) local topography, have been implemented and tested. One is based on the polar format algorithm followed by a unique autofocus technique, the other is a full bistatic time-domain backprojection technique. The processing system yields imagery of the specified resolution. Products enabled by this new system include topographic mapping through radar interferometry, and change detection techniques (amplitude and coherent change) for geolocation of the NASA LCROSS mission impact site.

Staggered Multiple-PRF Ultrafast Color Doppler.

PubMed

Posada, Daniel; Poree, Jonathan; Pellissier, Arnaud; Chayer, Boris; Tournoux, Francois; Cloutier, Guy; Garcia, Damien

2016-06-01

Color Doppler imaging is an established pulsed ultrasound technique to visualize blood flow non-invasively. High-frame-rate (ultrafast) color Doppler, by emissions of plane or circular wavefronts, allows severalfold increase in frame rates. Conventional and ultrafast color Doppler are both limited by the range-velocity dilemma, which may result in velocity folding (aliasing) for large depths and/or large velocities. We investigated multiple pulse-repetition-frequency (PRF) emissions arranged in a series of staggered intervals to remove aliasing in ultrafast color Doppler. Staggered PRF is an emission process where time delays between successive pulse transmissions change in an alternating way. We tested staggered dual- and triple-PRF ultrafast color Doppler, 1) in vitro in a spinning disc and a free jet flow, and 2) in vivo in a human left ventricle. The in vitro results showed that the Nyquist velocity could be extended to up to 6 times the conventional limit. We found coefficients of determination r(2) ≥ 0.98 between the de-aliased and ground-truth velocities. Consistent de-aliased Doppler images were also obtained in the human left heart. Our results demonstrate that staggered multiple-PRF ultrafast color Doppler is efficient for high-velocity high-frame-rate blood flow imaging. This is particularly relevant for new developments in ultrasound imaging relying on accurate velocity measurements.

Temporal variability of vena contracta and jet areas with color Doppler in aortic regurgitation: a chronic animal model study.

PubMed

Ishii, M; Jones, M; Shiota, T; Yamada, I; Sinclair, B; Heinrich, R S; Yoganathan, A P; Sahn, D J

1998-11-01

The purpose of our study was to determine the temporal variability of regurgitant color Doppler jet areas and the width of the color Doppler imaged vena contracta for evaluating the severity of aortic regurgitation. Twenty-nine hemodynamically different states were obtained pharmacologically in 8 sheep 20 weeks after surgery to produce aortic regurgitation. Aortic regurgitation was quantified by peak and mean regurgitant flow rates, regurgitant stroke volumes, and regurgitant fractions determined using pulmonary and aortic electromagnetic flow probes and meters balanced against each other. The regurgitant jet areas and the widths of color Doppler imaged vena contracta were measured at 4 different times during diastole to determine the temporal variability of this parameter. When measured at 4 different temporal points in diastole, a significant change was observed in the size of the color Doppler imaged regurgitant jet (percent of difference: from 31.1% to 904%; 233% +/- 245%). Simple linear regression analysis between each color jet area at 4 different periods in diastole and flow meter-based severity of the aortic regurgitation showed only weak correlation (0.23 < r < 0.49). In contrast, for most conditions only a slight change was observed in the width of the color Doppler imaged vena contracta during the diastolic regurgitant period (percent of difference, vena contracta: from 2.4% to 12.9%, 5.8% +/- 3.2%). In addition, for each period the width of the color Doppler imaged vena contracta at the 4 different time periods in diastole correlated quite strongly with volumetric measures of the severity of aortic regurgitation (0.81 < r < 0.90) and with the instantaneous flow rate for the corresponding period (0.85 < r < 0.87). Color Doppler imaged vena contracta may provide a simple, practical, and accurate method for quantifying aortic regurgitation, even when using a single frame color Doppler flow mapping image.

Volumetric vessel reconstruction method for absolute blood flow velocity measurement in Doppler OCT images

NASA Astrophysics Data System (ADS)

Qi, Li; Zhu, Jiang; Hancock, Aneeka M.; Dai, Cuixia; Zhang, Xuping; Frostig, Ron D.; Chen, Zhongping

2017-02-01

Doppler optical coherence tomography (DOCT) is considered one of the most promising functional imaging modalities for neuro biology research and has demonstrated the ability to quantify cerebral blood flow velocity at a high accuracy. However, the measurement of total absolute blood flow velocity (BFV) of major cerebral arteries is still a difficult problem since it not only relates to the properties of the laser and the scattering particles, but also relates to the geometry of both directions of the laser beam and the flow. In this paper, focusing on the analysis of cerebral hemodynamics, we presents a method to quantify the total absolute blood flow velocity in middle cerebral artery (MCA) based on volumetric vessel reconstruction from pure DOCT images. A modified region growing segmentation method is first used to localize the MCA on successive DOCT B-scan images. Vessel skeletonization, followed by an averaging gradient angle calculation method, is then carried out to obtain Doppler angles along the entire MCA. Once the Doppler angles are determined, the absolute blood flow velocity of each position on the MCA is easily found. Given a seed point position on the MCA, our approach could achieve automatic quantification of the fully distributed absolute BFV. Based on experiments conducted using a swept-source optical coherence tomography system, our approach could achieve automatic quantification of the fully distributed absolute BFV across different vessel branches in the rodent brain.

Feasibility study: real-time 3-D ultrasound imaging of the brain.

PubMed

Smith, Stephen W; Chu, Kengyeh; Idriss, Salim F; Ivancevich, Nikolas M; Light, Edward D; Wolf, Patrick D

2004-10-01

We tested the feasibility of real-time, 3-D ultrasound (US) imaging in the brain. The 3-D scanner uses a matrix phased-array transducer of 512 transmit channels and 256 receive channels operating at 2.5 MHz with a 15-mm diameter footprint. The real-time system scans a 65 degrees pyramid, producing up to 30 volumetric scans per second, and features up to five image planes as well as 3-D rendering, 3-D pulsed-wave and color Doppler. In a human subject, the real-time 3-D scans produced simultaneous transcranial horizontal (axial), coronal and sagittal image planes and real-time volume-rendered images of the gross anatomy of the brain. In a transcranial sheep model, we obtained real-time 3-D color flow Doppler scans and perfusion images using bolus injection of contrast agents into the internal carotid artery.

Echocardiography.

PubMed Central

Chambers, J. B.; Monaghan, M. J.; Jackson, G.

1988-01-01

Imaging echocardiography is an important extension of the clinical examination and will answer most questions in an emergency-for example, whether an enlarged cardiac shadow on the chest radiograph represents ventricular dilatation or an effusion. Doppler ultrasonography is essential for hospitals with an interest in cardiology because it provides direct haemodynamic data that are complementary to imaging. It requires more skill than imaging and may also be time consuming. Colour flow Doppler mapping is speedy and simple to use and aids the interpretation of continuous wave Doppler. It is therefore a natural companion to conventional Doppler, but there would have to be a high clinical load to justify its purchase. Images FIG 3 FIG 4 FIG 4 FIG 5 FIG 6 PMID:3143434

[Color Doppler ultrasonography--a new imaging procedure in maxillofacial surgery].

PubMed

Reinert, S; Lentrodt, J

1991-01-01

Colour Doppler ultrasonography shows blood flow in real time and colour by combining the features of real time B mode ultrasound and Doppler. At each point in the image the returning signal is interrogated for both amplitude and frequency information. The resulting image shows all non-moving structures in shades of gray and moving structures in shades of red or blue depending on direction and velocity. The technique of colour Doppler ultrasonography and our experiences in 63 examinations are described. The clinical application of this new simple non-invasive method in maxillo-facial surgery is discussed.

Focused ultrasound: concept for automated transcutaneous control of hemorrhage in austere settings.

PubMed

Kucewicz, John C; Bailey, Michael R; Kaczkowski, Peter J; Carter, Stephen J

2009-04-01

High intensity focused ultrasound (HIFU) is being developed for a range of clinical applications. Of particular interest to NASA and the military is the use of HIFU for traumatic injuries because HIFU has the unique ability to transcutaneously stop bleeding. Automation of this technology would make possible its use in remote, austere settings by personnel not specialized in medical ultrasound. Here a system to automatically detect and target bleeding is tested and reported. The system uses Doppler ultrasound images from a clinical ultrasound scanner for bleeding detection and hardware for HIFU therapy. The system was tested using a moving string to simulate blood flow and targeting was visualized by Schlieren imaging to show the focusing of the HIFU acoustic waves. When instructed by the operator, a Doppler ultrasound image is acquired and processed to detect and localize the moving string, and the focus of the HIFU array is electronically adjusted to target the string. Precise and accurate targeting was verified in the Schlieren images. An automated system to detect and target simulated bleeding has been built and tested. The system could be combined with existing algorithms to detect, target, and treat clinical bleeding.

In vivo endoscopic Doppler optical coherence tomography imaging of mouse colon

NASA Astrophysics Data System (ADS)

Welge, Weston A.; Barton, Jennifer K.

2016-03-01

Colorectal cancer remains the second deadliest cancer in the United States, despite the high sensitivity and specificity of colonoscopy and sigmoidoscopy. While these standard imaging procedures can accurately detect medium and large polyps, some studies have shown miss rates up to 25% for polyps less than 5 mm in diameter. An imaging modality capable of detecting small lesions could potentially improve patient outcomes. Optical coherence tomography (OCT) has been shown to be a powerful imaging modality for adenoma detection in a mouse model of colorectal cancer. While previous work has focused on analyzing the structural OCT images based on thickening of the mucosa and changes in light attenuation in depth, imaging the microvasculature of the colon may enable earlier detection of polyps. The structure and function of vessels grown to support tumor growth are markedly different from healthy vessels. Doppler OCT is capable of imaging microvessels in vivo. We developed a method of processing raw fringe data from a commercial swept-source OCT system using a lab-built miniature endoscope to extract microvessels. This method can be used to measure vessel count and density and to measure flow velocities. This may improve early detection and aid in the development of new chemopreventive and chemotherapeutic drugs. We present, to the best of our knowledge, the first endoscopic Doppler OCT images of in vivo mouse colon.

Detection of intracardiac shunt flow in atrial septal defect using a real-time two-dimensional color-coded Doppler flow imaging system and comparison with contrast two-dimensional echocardiography.

PubMed

Suzuki, Y; Kambara, H; Kadota, K; Tamaki, S; Yamazato, A; Nohara, R; Osakada, G; Kawai, C

1985-08-01

To evaluate the noninvasive detection of shunt flow using a newly developed real-time 2-dimensional color-coded Doppler flow imaging system (D-2DE), 20 patients were examined, including 10 with secundum atrial septal defect (ASD) and 10 control subjects. These results were compared with contrast 2-dimensional echocardiography (C-2DE). Doppler 2DE displayed the blood flow toward the transducer as red and the blood flow away from the transducer as blue in 8 shades, each shade adding green according to the degree of variance in Doppler frequency. In the patients with ASD, D-2DE clearly visualized left-to-right shunt flow in 7 of 10 patients. In 5 of these 7 patients, C-2DE showed a negative contrast effect in the same area of the right atrium. Thus, D-2DE increased the sensitivity over C-2DE for detecting left-to-right shunt flow (from 50% to 70%). However, the specificity was slightly less in D-2DE (90%) than C-2DE (100%). Doppler 2DE could not visualize right-to-left shunt flow in all patients with ASD, though C-2DE showed a positive contrast effect in the left-sided heart in 9 of 10 patients with ASD. Thus, D-2DE is clinically useful for detecting left-to-right shunt flow in patients with ASD.

An investigation into the blood-flow characteristics of telangiectatic skin lesions in systemic sclerosis using dual-wavelength laser Doppler imaging.

PubMed

Murray, A K; Moore, T L; Griffiths, C E M; Herrick, A L

2009-07-01

Superficial telangiectases associated with systemic sclerosis may be more responsive to treatment than those deeper in the dermis. We investigated whether dual-wavelength laser Doppler imaging (LDI) is sufficiently sensitive to ascertain the distribution of blood flow within telangiectases and whether blood flow relates to telangiectatic diameter. The perfusion and diameter of 20 telangiectases were measured in superficial and deeper layers of the skin using dual-wavelength LDI. Of 20 telangiectases, 18 had higher blood flow in the red (representing deeper blood flow), rather than the green (representing superficial blood flow) wavelength images. Clinically apparent diameters correlated with those of the superficial (r = 0.61, P = 0.01), but not with the deeper blood flow images. Hence, the apparent size of telangiectases at the skin surface does not predict blood flow through the microvessel(s) at deeper levels, and thus clinically apparent size is unlikely to predict treatment response. Dual-wavelength LDI may help predict treatment response.

Doppler imaging with dual-detection full-range frequency domain optical coherence tomography

PubMed Central

Meemon, Panomsak; Lee, Kye-Sung; Rolland, Jannick P.

2010-01-01

Most of full-range techniques for Frequency Domain Optical Coherence Tomography (FD-OCT) reported to date utilize the phase relation between consecutive axial lines to reconstruct a complex interference signal and hence may exhibit degradation in either mirror image suppression performance or detectable velocity dynamic range or both when monitoring a moving sample such as flow activity. We have previously reported a technique of mirror image removal by simultaneous detection of the quadrature components of a complex spectral interference called a Dual-Detection Frequency Domain OCT (DD-FD-OCT) [Opt. Lett. 35, 1058-1060 (2010)]. The technique enables full range imaging without any loss of acquisition speed and is intrinsically less sensitive to phase errors generated by involuntary movements of the subject. In this paper, we demonstrate the application of the DD-FD-OCT to a phase-resolved Doppler imaging without degradation in either mirror image suppression performance or detectable velocity dynamic range that were observed in other full-range Doppler methods. In order to accommodate for Doppler imaging, we have developed a fiber-based DD-FD-OCT that more efficiently utilizes the source power compared with the previous free-space DD-FD-OCT. In addition, the velocity sensitivity of the phase-resolved DD-FD-OCT was investigated, and the relation between the measured Doppler phase shift and set flow velocity of a flow phantom was verified. Finally, we demonstrate the Doppler imaging using the DD-FD-OCT in a biological sample. PMID:21258488

A Modified Subpulse SAR Processing Procedure Based on the Range-Doppler Algorithm for Synthetic Wideband Waveforms

PubMed Central

Lim, Byoung-Gyun; Woo, Jea-Choon; Lee, Hee-Young; Kim, Young-Soo

2008-01-01

Synthetic wideband waveforms (SWW) combine a stepped frequency CW waveform and a chirp signal waveform to achieve high range resolution without requiring a large bandwidth or the consequent very high sampling rate. If an efficient algorithm like the range-Doppler algorithm (RDA) is used to acquire the SAR images for synthetic wideband signals, errors occur due to approximations, so the images may not show the best possible result. This paper proposes a modified subpulse SAR processing algorithm for synthetic wideband signals which is based on RDA. An experiment with an automobile-based SAR system showed that the proposed algorithm is quite accurate with a considerable improvement in resolution and quality of the obtained SAR image. PMID:27873984

Comparison of NOAA/NMC stratospheric wind analyses with UARS high resolution Doppler Imager wind measurements

NASA Technical Reports Server (NTRS)

Miller, A. J.; Hays, P. B.; Abreu, V.; Long, C.; Kann, D.

1994-01-01

The NOAA National Weather Service currently derives global stratospheric wind analyses via several procedures. The first is the operational data assimilation system that extends from the surface up to about 50 mb and is in process of being tested to about 10 mb. In addition, a balanced wind is determined from the available Climate Analysis Center stratospheric height analyses that encompass the 70-0.4 mb region. The High Resolution Doppler Imager (HRDI) recently launched as a member of the Upper Atmosphere Research Satellite (UARS) is the first satellite instrument designed to measure winds in this stratospheric region and, thus, provide a basic evaluation of the NMC derived products. The HRDI accomplishes this by utilizing a triple-etalon Fabry-Perot interferometer that allows one to measure the Doppler shift of O2 absorption and emission features of the atmosphere, from which the wind field can be determined.

A micro-Doppler sonar for acoustic surveillance in sensor networks

NASA Astrophysics Data System (ADS)

Zhang, Zhaonian

Wireless sensor networks have been employed in a wide variety of applications, despite the limited energy and communication resources at each sensor node. Low power custom VLSI chips implementing passive acoustic sensing algorithms have been successfully integrated into an acoustic surveillance unit and demonstrated for detection and location of sound sources. In this dissertation, I explore active and passive acoustic sensing techniques, signal processing and classification algorithms for detection and classification in a multinodal sensor network environment. I will present the design and characterization of a continuous-wave micro-Doppler sonar to image objects with articulated moving components. As an example application for this system, we use it to image gaits of humans and four-legged animals. I will present the micro-Doppler gait signatures of a walking person, a dog and a horse. I will discuss the resolution and range of this micro-Doppler sonar and use experimental results to support the theoretical analyses. In order to reduce the data rate and make the system amenable to wireless sensor networks, I will present a second micro-Doppler sonar that uses bandpass sampling for data acquisition. Speech recognition algorithms are explored for biometric identifications from one's gait, and I will present and compare the classification performance of the two systems. The acoustic micro-Doppler sonar design and biometric identification results are the first in the field as the previous work used either video camera or microwave technology. I will also review bearing estimation algorithms and present results of applying these algorithms for bearing estimation and tracking of moving vehicles. Another major source of the power consumption at each sensor node is the wireless interface. To address the need of low power communications in a wireless sensor network, I will also discuss the design and implementation of ultra wideband transmitters in a three dimensional silicon on insulator process. Lastly, a prototype of neuromorphic interconnects using ultra wideband radio will be presented.

Doppler imaging using spectrally-encoded endoscopy

PubMed Central

Yelin, Dvir; Bouma, B. E.; Rosowsky, J. J.; Tearney, G. J.

2009-01-01

The capability to image tissue motion such as blood flow through an endoscope could have many applications in medicine. Spectrally encoded endoscopy (SEE) is a recently introduced technique that utilizes a single optical fiber and miniature diffractive optics to obtain endoscopic images through small diameter probes. Using spectral-domain interferometry, SEE is furthermore capable of three-dimensional volume imaging at video rates. Here we show that by measuring relative spectral phases, this technology can additionally measure Doppler shifts. Doppler SEE is demonstrated in flowing Intralipid phantoms and vibrating middle ear ossicles. PMID:18795020

Doppler color imaging. Principles and instrumentation.

PubMed

Kremkau, F W

1992-01-01

DCI acquires Doppler-shifted echoes from a cross-section of tissue scanned by an ultrasound beam. These echoes are then presented in color and superimposed on the gray-scale anatomic image of non-Doppler-shifted echoes received during the scan. The flow echoes are assigned colors according to the color map chosen. Usually red, yellow, or white indicates positive Doppler shifts (approaching flow) and blue, cyan, or white indicates negative shifts (receding flow). Green is added to indicate variance (disturbed or turbulent flow). Several pulses (the number is called the ensemble length) are needed to generate a color scan line. Linear, convex, phased, and annular arrays are used to acquire the gray-scale and color-flow information. Doppler color-flow instruments are pulsed-Doppler instruments and are subject to the same limitations, such as Doppler angle dependence and aliasing, as other Doppler instruments. Color controls include gain, TGC, map selection, variance on/off, persistence, ensemble length, color/gray priority. Nyquist limit (PRF), baseline shift, wall filter, and color window angle, location, and size. Doppler color-flow instruments generally have output intensities intermediate between those of gray-scale imaging and pulsed-Doppler duplex instruments. Although there is no known risk with the use of color-flow instruments, prudent practice dictates that they be used for medical indications and with the minimum exposure time and instrument output required to obtain the needed diagnostic information.

Choroidal imaging by one-micrometer dual-beam Doppler optical coherence angiography with adjustable velocity range

NASA Astrophysics Data System (ADS)

Jaillon, Franck; Makita, Shuichi; Yasuno, Yoshiaki

2012-03-01

Ability of a new version of one-micrometer dual-beam optical coherence angiography (OCA) based on Doppler optical coherence tomography (OCT), is demonstrated for choroidal vasculature imaging. A particular feature of this system is the adjustable time delay between two probe beams. This allows changing the measurable velocity range of moving constituents such as blood without alteration of the scanning protocol. Since choroidal vasculature is made of vessels having blood flows with different velocities, this technique provides a way of discriminating vessels according to the velocity range of their inner flow. An example of choroid imaging of a normal emmetropic eye is here given. It is shown that combining images acquired with different velocity ranges provides an enhanced vasculature representation. This method may be then useful for pathological choroid characterization.

Hybrid space-airborne bistatic SAR geometric resolutions

NASA Astrophysics Data System (ADS)

Moccia, Antonio; Renga, Alfredo

2009-09-01

Performance analysis of Bistatic Synthetic Aperture Radar (SAR) characterized by arbitrary geometric configurations is usually complex and time-consuming since system impulse response has to be evaluated by bistatic SAR processing. This approach does not allow derivation of general equations regulating the behaviour of image resolutions with varying the observation geometry. It is well known that for an arbitrary configuration of bistatic SAR there are not perpendicular range and azimuth directions, but the capability to produce an image is not prevented as it depends only on the possibility to generate image pixels from time delay and Doppler measurements. However, even if separately range and Doppler resolutions are good, bistatic SAR geometries can exist in which imaging capabilities are very poor when range and Doppler directions become locally parallel. The present paper aims to derive analytical tools for calculating the geometric resolutions of arbitrary configuration of bistatic SAR. The method has been applied to a hybrid bistatic Synthetic Aperture Radar formed by a spaceborne illuminator and a receiving-only airborne forward-looking Synthetic Aperture Radar (F-SAR). It can take advantage of the spaceborne illuminator to dodge the limitations of monostatic FSAR. Basic modeling and best illumination conditions have been detailed in the paper.

Modern Diagnostic Techniques for the Assessment of Ocular Blood Flow in Myopia: Current State of Knowledge.

PubMed

Grudzińska, Ewa; Modrzejewska, Monika

2018-01-01

Myopia is the most common refractive error and the subject of interest of various studies assessing ocular blood flow. Increasing refractive error and axial elongation of the eye result in the stretching and thinning of the scleral, choroid, and retinal tissues and the decrease in retinal vessel diameter, disturbing ocular blood flow. Local and systemic factors known to change ocular blood flow include glaucoma, medications and fluctuations in intraocular pressure, and metabolic parameters. Techniques and tools assessing ocular blood flow include, among others, laser Doppler flowmetry (LDF), retinal function imager (RFI), laser speckle contrast imaging (LSCI), magnetic resonance imaging (MRI), optical coherence tomography angiography (OCTA), pulsatile ocular blood flowmeter (POBF), fundus pulsation amplitude (FPA), colour Doppler imaging (CDI), and Doppler optical coherence tomography (DOCT). Many researchers consistently reported lower blood flow parameters in myopic eyes regardless of the used diagnostic method. It is unclear whether this is a primary change that causes secondary thinning of ocular tissues or quite the opposite; that is, the mechanical stretching of the eye wall reduces its thickness and causes a secondary lower demand of tissues for oxygen. This paper presents a review of studies assessing ocular blood flow in myopes.

Four-dimensional ultrasonography of the fetal heart using color Doppler spatiotemporal image correlation.

PubMed

Gonçalves, Luís F; Romero, Roberto; Espinoza, Jimmy; Lee, Wesley; Treadwell, Marjorie; Chintala, Kavitha; Brandl, Helmut; Chaiworapongsa, Tinnakorn

2004-04-01

To describe clinical and research applications of 4-dimensional imaging of the fetal heart using color Doppler spatiotemporal image correlation. Forty-four volume data sets were acquired by color Doppler spatiotemporal image correlation. Seven subjects were examined: 4 fetuses without abnormalities, 1 fetus with ventriculomegaly and a hypoplastic cerebellum but normal cardiac anatomy, and 2 fetuses with cardiac anomalies detected by fetal echocardiography (1 case of a ventricular septal defect associated with trisomy 21 and 1 case of a double-inlet right ventricle with a 46,XX karyotype). The median gestational age at the time of examination was 21 3/7 weeks (range, 19 5/7-34 0/7 weeks). Volume data sets were reviewed offline by multiplanar display and volume-rendering methods. Representative images and online video clips illustrating the diagnostic potential of this technology are presented. Color Doppler spatiotemporal image correlation allowed multiplanar visualization of ventricular septal defects, multiplanar display and volume rendering of tricuspid regurgitation, volume rendering of the outflow tracts by color and power Doppler ultrasonography (both in a normal case and in a case of a double-inlet right ventricle with a double-outlet right ventricle), and visualization of venous streams at the level of the foramen ovale. Color Doppler spatiotemporal image correlation has the potential to simplify visualization of the outflow tracts and improve the evaluation of the location and extent of ventricular septal defects. Other applications include 3-dimensional evaluation of regurgitation jets and venous streams at the level of the foramen ovale.

Noninvasive diagnosis of right-sided extracardiac conduit obstruction by combined magnetic resonance imaging and continuous-wave Doppler echocardiography.

PubMed

Canter, C E; Gutierrez, F R; Molina, P; Hartmann, A F; Spray, T L

1991-04-01

Right-sided extracardiac conduits are frequently complicated by obstruction over time. We compared the utility of two-dimensional and Doppler echocardiography and magnetic resonance imaging in the diagnosis of postoperative right-sided obstruction with cardiac catheterization and angiography in 10 patients with xenograft or homograft conduits. Correlation (r = 0.95) between continuous-wave Doppler estimates and catheter pullback pressure gradients across the conduits was excellent. Echocardiography could only visualize five of 10 conduits in their entirety. Magnetic resonance imaging visualized all conduits and showed statistically significant (kappa = 0.58) agreement with angiography in the localization and estimation of severity of a variety of right-sided obstructions in these patients. However, flow voids created by the metallic ring around xenograft valves led to a false negative diagnosis of valvular stenosis in four patients when magnetic resonance imaging was used alone. Doppler studies correctly indicated obstruction in these patients. The combination of magnetic resonance imaging studies and continuous-wave Doppler echocardiography can be useful to noninvasively evaluate right-sided obstruction in postoperative patients with right-sided extracardiac conduits.

Using local correlation tracking to recover solar spectral information from a slitless spectrograph

NASA Astrophysics Data System (ADS)

Courrier, Hans T.; Kankelborg, Charles C.

2018-01-01

The Multi-Order Solar EUV Spectrograph (MOSES) is a sounding rocket instrument that utilizes a concave spherical diffraction grating to form simultaneous images in the diffraction orders m=0, +1, and -1. MOSES is designed to capture high-resolution cotemporal spectral and spatial information of solar features over a large two-dimensional field of view. Our goal is to estimate the Doppler shift as a function of position for every MOSES exposure. Since the instrument is designed to operate without an entrance slit, this requires disentangling overlapping spectral and spatial information in the m=±1 images. Dispersion in these images leads to a field-dependent displacement that is proportional to Doppler shift. We identify these Doppler shift-induced displacements for the single bright emission line in the instrument passband by comparing images from each spectral order. We demonstrate the use of local correlation tracking as a means to quantify these differences between a pair of cotemporal image orders. The resulting vector displacement field is interpreted as a measurement of the Doppler shift. Since three image orders are available, we generate three Doppler maps from each exposure. These may be compared to produce an error estimate.

Comparative study evaluating the role of color Doppler sonography and computed tomography in predicting chest wall invasion by lung tumors.

PubMed

Sripathi, Smiti; Mahajan, Abhishek

2013-09-01

To analyze qualitative and quantitative parameters of lung tumors by color Doppler sonography, determine the role of color Doppler sonography in predicting chest wall invasion by lung tumors using spectral waveform analysis, and compare color Doppler sonography and computed tomography (CT) for predicting chest wall invasion by lung tumors. Between March and September 2007, 55 patients with pleuropulmonary lesions on chest radiography were assessed by grayscale and color Doppler sonography for chest wall invasion. Four patients were excluded from the study because of poor acoustic windows. Quantitative and qualitative sonographic examinations of the lesions were performed using grayscale and color Doppler imaging. The correlation between the color Doppler and CT findings was determined, and the final outcomes were correlated with the histopathologic findings. Of a total of 51 lesions, 32 were malignant. Vascularity was present on color Doppler sonography in 28 lesions, and chest wall invasion was documented in 22 cases. Computed tomography was performed in 24 of 28 evaluable malignant lesions, and the findings were correlated with the color Doppler findings for chest wall invasion. Of the 24 patients who underwent CT, 19 showed chest wall invasion. The correlation between the color Doppler and CT findings revealed that color Doppler sonography had sensitivity of 95.6% and specificity of 100% for assessing chest wall invasion, whereas CT had sensitivity of 85.7% and specificity of 66.7%. Combined qualitative and quantitative color Doppler sonography can predict chest wall invasion by lung tumors with better sensitivity and specificity than CT. Although surgery is the reference standard, color Doppler sonography is a readily available, affordable, and noninvasive in vivo diagnostic imaging modality that is complementary to CT and magnetic resonance imaging for lung cancer staging.

Swept-source based, single-shot, multi-detectable velocity range Doppler optical coherence tomography

PubMed Central

Meemon, Panomsak; Rolland, Jannick P.

2010-01-01

Phase-Resolved Doppler Optical Coherence Tomography (PR-DOCT) allows visualization and characterization of the location, direction, velocity, and profile of flow activity embedded in a static sample structure. The detectable Velocity Dynamic Range (VDR) of each particular PR-DOCT system is governed by a detectable Doppler phase shift, a flow angle, and an acquisition time interval used to determine the Doppler phase shift. In general, the lower boundary of the detectable Doppler phase shift is limited by the phase stability of the system, while the upper boundary is limited by the π phase ambiguity. For a given range of detectable Doppler phase shift, shortening the acquisition duration will increase not only the maximum detectable velocity but unfortunately also the minimum detectable velocity, which may lead to the invisibility of a slow flow. In this paper, we present an alternative acquisition scheme for PR-DOCT that extends the lower limit of the velocity dynamic range, while maintaining the maximum detectable velocity, hence increasing the overall VDR of PR-DOCT system. The essence of the approach is to implement a technique of multi-scale measurement to simultaneously acquire multiple VDRs in a single measurement. We demonstrate an example of implementation of the technique in a dual VDR DOCT, where two Doppler maps having different detectable VDRs were simultaneously detected, processed, and displayed in real time. One was a fixed VDR DOCT capable of measuring axial velocity of up to 10.9 mm/s without phase unwrapping. The other was a variable VDR DOCT capable of adjusting its detectable VDR to reveal slow flow information down to 11.3 μm/s. The technique is shown to effectively extend the overall detectable VDR of the PR-DOCT system. Examples of real time Doppler imaging of an African frog tadpole are demonstrated using the dual-VDR DOCT system. PMID:21258521

Imaging nanoparticle flow using magneto-motive optical Doppler tomography.

PubMed

Kim, Jeehyun; Oh, Junghwan; Milner, Thomas E; Nelson, J Stuart

2007-01-24

We introduce a novel approach for imaging solutions of superparamagnetic iron oxide (SPIO) nanoparticles using magneto-motive optical Doppler tomography (MM-ODT). MM-ODT combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect nanoparticles flowing through a microfluidic channel. A solenoid with a cone-shaped ferrite core extensively increased the magnetic field strength (B(max) = 1 T, [Formula: see text]) at the tip of the core and also focused the magnetic field in microfluidic channels containing nanoparticle solutions. Nanoparticle contrast was demonstrated in a microfluidic channel filled with an SPIO solution by imaging the Doppler frequency shift which was observed independently of the nanoparticle flow rate and direction. Results suggest that MM-ODT may be applied to image Doppler shift of SPIO nanoparticles in microfluidic flows with high contrast.

Comparing Goldstone Solar System Radar Earth-based Observations of Mars with Orbital Datasets

NASA Technical Reports Server (NTRS)

Haldemann, A. F. C.; Larsen, K. W.; Jurgens, R. F.; Slade, M. A.

2005-01-01

The Goldstone Solar System Radar (GSSR) has collected a self-consistent set of delay-Doppler near-nadir radar echo data from Mars since 1988. Prior to the Mars Global Surveyor (MGS) Mars Orbiter Laser Altimeter (MOLA) global topography for Mars, these radar data provided local elevation information, along with radar scattering information with global coverage. Two kinds of GSSR Mars delay-Doppler data exist: low 5 km x 150 km resolution and, more recently, high (5 to 10 km) spatial resolution. Radar data, and non-imaging delay-Doppler data in particular, requires significant data processing to extract elevation, reflectivity and roughness of the reflecting surface. Interpretation of these parameters, while limited by the complexities of electromagnetic scattering, provide information directly relevant to geophysical and geomorphic analyses of Mars. In this presentation we want to demonstrate how to compare GSSR delay-Doppler data to other Mars datasets, including some idiosyncracies of the radar data. Additional information is included in the original extended abstract.

Laser Doppler velocimeter system simulation for sensing aircraft wake vortices

NASA Technical Reports Server (NTRS)

Thomson, J. A. L.; Meng, J. C. S.

1974-01-01

A hydrodynamic model of aircraft vortex wakes in an irregular wind shear field near the ground is developed and used as a basis for modeling the characteristics of a laser Doppler detection and vortex location system. The trailing vortex sheet and the wind shear are represented by discrete free vortices distributed over a two-dimensional grid. The time dependent hydrodynamic equations are solved by direct numerical integration in the Boussinesq approximation. The ground boundary is simulated by images, and fast Fourier Transform techniques are used to evaluate the vorticity stream function. The atmospheric turbulence was simulated by constructing specific realizations at time equal to zero, assuming that Kolmogoroff's law applies, and that the dissipation rate is constant throughout the flow field. The response of a simulated laser Doppler velocimeter is analyzed by simulating the signal return from the flow field as sensed by a simulation of the optical/electronic system.

Evaluation of a Delay-Doppler Imaging Algorithm Based on the Wigner-Ville Distribution

DTIC Science & Technology

1989-10-18

exchanging the frequency and time variables. 2.3 PROPERTIES OF THE WIGNER - VILLE DISTRIBUTION A partial list of the properties of the WVD is provided...ESD-TH-89-163 N Technical Report (N R55 00 Lfl Evaluation of a Delay-Doppler Imaging Algorithm Based on the Wigner - Ville Distribution K.I. Schultz 18...DOPPLER IMAGING ALGORITHM BASED ON THE WIGNER - VILLE DISTRIBUTION K.I. SCHULTZ Group 52 TECHNICAL REPORT 855 18 OCTOBER 1989 Approved for public release

Color mapping of one specific velocity of a biological fluid flows with complex geometry using optical coherence tomography

NASA Astrophysics Data System (ADS)

Potlov, A. Yu.; Frolov, S. V.; Proskurin, S. G.

2018-04-01

The method of Doppler color mapping of one specific (previously chosen) velocity in a turbulent flow inside biological tissues using optical coherence tomography is described. The key features of the presented method are: the raw data are separated into three parts, corresponding to the unmoving biological tissue, the positively and negatively directed biological fluid flows; the further independent signal processing procedure yields the structure image and two images of the chosen velocity, which are then normalised, encoded and joined. The described method can be used to obtain in real time the anatomical maps of the chosen velocities in normal and pathological states. The described method can be applied not only in optical coherence tomography, but also in endoscopic and Doppler ultrasonic medical imaging systems.

Transthoracic Ultrafast Doppler Imaging of Human Left Ventricular Hemodynamic Function

PubMed Central

Osmanski, Bruno-Félix; Maresca, David; Messas, Emmanuel; Tanter, Mickael; Pernot, Mathieu

2016-01-01

Heart diseases can affect intraventricular blood flow patterns. Real-time imaging of blood flow patterns is challenging because it requires both a high frame rate and a large field of view. To date, standard Doppler techniques can only perform blood flow estimation with high temporal resolution within small regions of interest. In this work, we used ultrafast imaging to map in 2D human left ventricular blood flow patterns during the whole cardiac cycle. Cylindrical waves were transmitted at 4800 Hz with a transthoracic phased array probe to achieve ultrafast Doppler imaging of the left ventricle. The high spatio-temporal sampling of ultrafast imaging permits to rely on a much more effective wall filtering and to increase sensitivity when mapping blood flow patterns during the pre-ejection, ejection, early diastole, diastasis and late diastole phases of the heart cycle. The superior sensitivity and temporal resolution of ultrafast Doppler imaging makes it a promising tool for the noninvasive study of intraventricular hemodynamic function. PMID:25073134

Use of speckle for determining the response characteristics of Doppler imaging radars

NASA Technical Reports Server (NTRS)

Tilley, D. G.

1986-01-01

An optical model is developed for imaging optical radars such as the SAR on Seasat and the Shuttle Imaging Radar (SIR-B) by analyzing the Doppler shift of individual speckles in the image. The signal received at the spacecraft is treated in terms of a Fresnel-Kirchhoff integration over all backscattered radiation within a Huygen aperture at the earth. Account is taken of the movement of the spacecraft along the orbital path between emission and reception. The individual points are described by integration of the point source amplitude with a Green's function scattering kernel. Doppler data at each point furnishes the coordinates for visual representations. A Rayleigh-Poisson model of the surface scattering characteristics is used with Monte Carlo methods to generate simulations of Doppler radar speckle that compare well with Seasat SAR data SIR-B data.

Parameter Estimation and Image Reconstruction of Rotating Targets with Vibrating Interference in the Terahertz Band

NASA Astrophysics Data System (ADS)

Yang, Qi; Deng, Bin; Wang, Hongqiang; Qin, Yuliang

2017-07-01

Rotation is one of the typical micro-motions of radar targets. In many cases, rotation of the targets is always accompanied with vibrating interference, and it will significantly affect the parameter estimation and imaging, especially in the terahertz band. In this paper, we propose a parameter estimation method and an image reconstruction method based on the inverse Radon transform, the time-frequency analysis, and its inverse. The method can separate and estimate the rotating Doppler and the vibrating Doppler simultaneously and can obtain high-quality reconstructed images after vibration compensation. In addition, a 322-GHz radar system and a 25-GHz commercial radar are introduced and experiments on rotating corner reflectors are carried out in this paper. The results of the simulation and experiments verify the validity of the methods, which lay a foundation for the practical processing of the terahertz radar.

Micro-Doppler analysis of multiple frequency continuous wave radar signatures

NASA Astrophysics Data System (ADS)

Anderson, Michael G.; Rogers, Robert L.

2007-04-01

Micro-Doppler refers to Doppler scattering returns produced by non rigid-body motion. Micro-Doppler gives rise to many detailed radar image features in addition to those associated with bulk target motion. Targets of different classes (for example, humans, animals, and vehicles) produce micro-Doppler images that are often distinguishable even by nonexpert observers. Micro-Doppler features have great potential for use in automatic target classification algorithms. Although the potential benefit of using micro-Doppler in classification algorithms is high, relatively little experimental (non-synthetic) micro-Doppler data exists. Much of the existing experimental data comes from highly cooperative targets (human or vehicle targets directly approaching the radar). This research involved field data collection and analysis of micro-Doppler radar signatures from non-cooperative targets. The data was collected using a low cost Xband multiple frequency continuous wave (MFCW) radar with three transmit frequencies. The collected MFCW radar signatures contain data from humans, vehicles, and animals. The presented data includes micro-Doppler signatures previously unavailable in the literature such as crawling humans and various animal species. The animal micro-Doppler signatures include deer, dog, and goat datasets. This research focuses on the analysis of micro-Doppler from noncooperative targets approaching the radar at various angles, maneuvers, and postures.

Echocardiographic assessment of left ventricular diastolic function.

PubMed

Pirat, Bahar; Zoghbi, William A

2007-09-01

Assessment of diastolic function and left ventricular filling pressures in the setting of both normal and reduced systolic function is of major importance particularly in patients with dyspnea. Since multiple echocardiography parameters are used to assess diastolic function each with some limitations, a comprehensive approach should be applied. Transmitral Doppler flow should be evaluated in combination with newer, less load dependent Doppler techniques. Tissue Doppler imaging provides accurate, well validated data regarding diastolic properties and filling pressures of the left ventricle. Tissue Doppler imaging should be the part of a routine echocardiography study due to its ease of use and high reproducibility. Pulmonary vein Doppler and flow propagation velocity should be incorporated into the evaluation when needed.

Ambiguities in spaceborne synthetic aperture radar systems

NASA Technical Reports Server (NTRS)

Li, F. K.; Johnson, W. T. K.

1983-01-01

An examination of aspects of spaceborne SAR time delay and Doppler ambiguities has led to the formulation of an accurate method for the evaluation of the ratio of ambiguity intensities to that of the signal, which has been applied to the nominal SAR system on Seasat. After discussing the variation of this ratio as a function of orbital latitude and attitude control error, it is shown that the detailed range migration-azimuth phase history of an ambiguity is different from that of a signal, so that the images of ambiguities are dispersed. Seasat SAR dispersed images are presented, and their dispersions are eliminated through an adjustment of the processing parameters. A method is also presented which uses a set of multiple pulse repetition sequences to determine the Doppler centroid frequency absolute values for SARs with high carrier frequencies and poor attitude measurements.

Instantaneous Doppler Global Velocimetry Measurements of a Rotor Wake: Lessons Learned

NASA Technical Reports Server (NTRS)

Meyers, James; Fleming, Gary A.; Gorton, Susan Althoff; Berry, John D.

1998-01-01

A combined Doppler Global Velocimetry (DGV) and Projection Moir Interferometry (PMI) investigation of a helicopter rotor wake flow field and rotor blade deformation is presented. The three-component DGV system uses a single-frequency, frequency-doubled Nd:YAG laser to obtain instantaneous velocity measurements in the flow. The PMI system uses a pulsed laser-diode bar to obtain blade bending and twist measurements at the same instant that DGV measured the flow. The application of pulse lasers to DGV and PMI in large-scale wind tunnel applications represents a major step forward in the development of these technologies. As such, a great deal was learned about the difficulties of using these instruments to obtain instantaneous measurements in large facilities. Laser speckle and other image noise in the DGV data images were found to be traceable to the Nd:YAG laser. Although image processing techniques were used to virtually eliminate laser speckle noise, the source of low-frequency image noise is still under investigation. The PMI results agreed well with theoretical predictions of blade bending and twist.

Doppler Ultrasound: What Is It Used for?

MedlinePlus

... During a Doppler ultrasound, a technician trained in ultrasound imaging (sonographer) presses a small hand-held device (transducer), ... neurologic-disorders/neurologic-tests-and-procedures/other-neurologic-imaging-studies. Accessed Oct. 18, 2016. ... . Mayo Clinic Footer Legal ...

Autonomous Sensors for Large Scale Data Collection

NASA Astrophysics Data System (ADS)

Noto, J.; Kerr, R.; Riccobono, J.; Kapali, S.; Migliozzi, M. A.; Goenka, C.

2017-12-01

Presented here is a novel implementation of a "Doppler imager" which remotely measures winds and temperatures of the neutral background atmosphere at ionospheric altitudes of 87-300Km and possibly above. Incorporating both recent optical manufacturing developments, modern network awareness and the application of machine learning techniques for intelligent self-monitoring and data classification. This system achieves cost savings in manufacturing, deployment and lifetime operating costs. Deployed in both ground and space-based modalities, this cost-disruptive technology will allow computer models of, ionospheric variability and other space weather models to operate with higher precision. Other sensors can be folded into the data collection and analysis architecture easily creating autonomous virtual observatories. A prototype version of this sensor has recently been deployed in Trivandrum India for the Indian Government. This Doppler imager is capable of operation, even within the restricted CubeSat environment. The CubeSat bus offers a very challenging environment, even for small instruments. The lack of SWaP and the challenging thermal environment demand development of a new generation of instruments; the Doppler imager presented is well suited to this environment. Concurrent with this CubeSat development is the development and construction of ground based arrays of inexpensive sensors using the proposed technology. This instrument could be flown inexpensively on one or more CubeSats to provide valuable data to space weather forecasters and ionospheric scientists. Arrays of magnetometers have been deployed for the last 20 years [Alabi, 2005]. Other examples of ground based arrays include an array of white-light all sky imagers (THEMIS) deployed across Canada [Donovan et al., 2006], oceans sensors on buoys [McPhaden et al., 2010], and arrays of seismic sensors [Schweitzer et al., 2002]. A comparable array of Doppler imagers can be constructed and deployed on the ground, to compliment the CubeSat data.

Bioengineering assessment of acupuncture, part 8: innovative moxibustion.

PubMed

Litscher, Gerhard

2010-01-01

The actual Chinese character for acupuncture, translated literally, means "acupuncture-moxibustion." This shows the enormous importance of moxibustion in Asia for thousands of years. In this review article, the history of the burning of mugwort (moxatherapy) is briefly described. In addition, new technical methods such as new infrared-moxa or laser-moxa devices, electrobian stone moxibustion, and the investigations of a new needle-moxa system using high-tech methods such as thermography, laser Doppler flowmetry, and laser Doppler imaging are presented.

The application of color Doppler flow imaging in the diagnosis and therapeutic effect evaluation of erectile dysfunction

PubMed Central

Xuan, Xu-Jun; Bai, Gang; Zhang, Cai-Xia; Xu, Chao; Lu, Fu-Ding; Peng, Yang; Ma, Gang; Han, Cong-Hui; Chen, Jun

2016-01-01

We aim to investigate the correlations between hemodynamic parameters, penile rigidity grading, and the therapeutic effects of phosphodiesterase type 5 inhibitors using color Doppler flow imaging after intracavernosal injection in patients with erectile dysfunction. This study involved 164 patients. After intracavernosal injection with a mixture of papaverine (60 mg), prostaglandin E1 (10 μg), and lidocaine (2%, 0.5–1 ml), the penile vessels were assessed using color Doppler flow imaging. Penile rigidity was classified based on the Erection Hardness Score system as Grades 4, 3, 2 or 1 (corresponding to Schramek Grades V to II). Then, the patients were given oral sildenafil (50–100 mg) and scored according to the International Index of Erectile Function (IIEF-5) questionnaire. The number of patients with penile rigidities of Schramek Grades II to V was 14, 18, 21, and 111, respectively. The IIEF-5 score was positively correlated with the refilling index of the penile cavernosal artery (r = 0.79, P < 0.05), the peak systolic velocity (r = 0.45, P < 0.05), and penile rigidity (r = 0.75, P < 0.05), and was negatively correlated with the end diastolic velocity (r = −0.74, P < 0.05). For patients with erectile dysfunction, both the IIEF-5 score after sildenafil administration, which is correlated with penile rigidity, and the hemodynamic parameters detected using color Doppler flow imaging may predict the effects of phosphodiesterase type 5 inhibitor treatment and could provide a reasonable model for the targeted-treatment of erectile dysfunction. PMID:25994651

Comprasion of ovarian stromal blood flow measured by color Doppler ultrasonography in polycystic ovary syndrome patients and healthy women with ultrasonographic evidence of polycystic.

PubMed

Ozdemir, Ozhan; Sari, Mustafa Erkan; Kalkan, Dilek; Koc, Esra Meltem; Ozdemir, Seyda; Atalay, Cemal Resat

2015-04-01

To compare ovarian stromal artery blood flows measured by Doppler ultrasonography of polycystic ovary syndrome (PCOS) patients and healthy women with polycystic ovarian image in ultrasonography. Forty-two patients diagnosed with PCOS according to the criteria of 2003 Rotterdam Concencus Conferance on PCOS and 38 healthy volunteers with polycystic ovarian image in ultrasonography were included in the study. Ovarian volumes and ovarian stromal artery blood flows were measured by 3-dimensional (3-D) ultrasonography and Doppler ultrasonography in all patients. In patients with PCOS, ovarian stromal artery pulsatility index (PI) and resistivity index (RI) were found significantly different from healthy women with polycystic ovarian image in ultrasonography (p < 0.05). 3-D ovarian volumes were found significantly higher in patients with PCOS (p < 0.05), and a negative correlation was also obtained between ovarian volumes and ovarian stromal artery resistivity indices. Ovarian stromal artery Doppler examination could have an importance to explain the pathophysiology of PCOS, but there are few publications in the literature about PCOS and the details of ovarian stromal artery Doppler parameters in patients with polycystic ovarian image only. We conclude that Doppler ultrasonography findings of PCOS patients might be helpful in understanding the clinical follow-up and etiology of the disease.

MEMS-Based Handheld Fourier Domain Doppler Optical Coherence Tomography for Intraoperative Microvascular Anastomosis Imaging

PubMed Central

Huang, Yong; Furtmüller, Georg J.; Tong, Dedi; Zhu, Shan; Lee, W. P. Andrew; Brandacher, Gerald; Kang, Jin U.

2014-01-01

Purpose To demonstrate the feasibility of a miniature handheld optical coherence tomography (OCT) imager for real time intraoperative vascular patency evaluation in the setting of super-microsurgical vessel anastomosis. Methods A novel handheld imager Fourier domain Doppler optical coherence tomography based on a 1.3-µm central wavelength swept source for extravascular imaging was developed. The imager was minimized through the adoption of a 2.4-mm diameter microelectromechanical systems (MEMS) scanning mirror, additionally a 12.7-mm diameter lens system was designed and combined with the MEMS mirror to achieve a small form factor that optimize functionality as a handheld extravascular OCT imager. To evaluate in-vivo applicability, super-microsurgical vessel anastomosis was performed in a mouse femoral vessel cut and repair model employing conventional interrupted suture technique as well as a novel non-suture cuff technique. Vascular anastomosis patency after clinically successful repair was evaluated using the novel handheld OCT imager. Results With an adjustable lateral image field of view up to 1.5 mm by 1.5 mm, high-resolution simultaneous structural and flow imaging of the blood vessels were successfully acquired for BALB/C mouse after orthotopic hind limb transplantation using a non-suture cuff technique and BALB/C mouse after femoral artery anastomosis using a suture technique. We experimentally quantify the axial and lateral resolution of the OCT to be 12.6 µm in air and 17.5 µm respectively. The OCT has a sensitivity of 84 dB and sensitivity roll-off of 5.7 dB/mm over an imaging range of 5 mm. Imaging with a frame rate of 36 Hz for an image size of 1000(lateral)×512(axial) pixels using a 50,000 A-lines per second swept source was achieved. Quantitative vessel lumen patency, lumen narrowing and thrombosis analysis were performed based on acquired structure and Doppler images. Conclusions A miniature handheld OCT imager that can be used for intraoperative evaluation of microvascular anastomosis was successfully demonstrated. PMID:25474742

Specialization of the auditory system for the processing of bio-sonar information in the frequency domain: Mustached bats.

PubMed

Suga, Nobuo

2018-04-01

For echolocation, mustached bats emit velocity-sensitive orientation sounds (pulses) containing a constant-frequency component consisting of four harmonics (CF 1-4 ). They show unique behavior called Doppler-shift compensation for Doppler-shifted echoes and hunting behavior for frequency and amplitude modulated echoes from fluttering insects. Their peripheral auditory system is highly specialized for fine frequency analysis of CF 2 (∼61.0 kHz) and detecting echo CF 2 from fluttering insects. In their central auditory system, lateral inhibition occurring at multiple levels sharpens V-shaped frequency-tuning curves at the periphery and creates sharp spindle-shaped tuning curves and amplitude tuning. The large CF 2 -tuned area of the auditory cortex systematically represents the frequency and amplitude of CF 2 in a frequency-versus-amplitude map. "CF/CF" neurons are tuned to a specific combination of pulse CF 1 and Doppler-shifted echo CF 2 or 3 . They are tuned to specific velocities. CF/CF neurons cluster in the CC ("C" stands for CF) and DIF (dorsal intrafossa) areas of the auditory cortex. The CC area has the velocity map for Doppler imaging. The DIF area is particularly for Dopper imaging of other bats approaching in cruising flight. To optimize the processing of behaviorally relevant sounds, cortico-cortical interactions and corticofugal feedback modulate the frequency tuning of cortical and sub-cortical auditory neurons and cochlear hair cells through a neural net consisting of positive feedback associated with lateral inhibition. Copyright © 2018 Elsevier B.V. All rights reserved.

The Place of Nailfold Capillaroscopy Among Instrumental Methods for Assessment of Some Peripheral Ischaemic Syndromes in Rheumatology.

PubMed

Lambova, Sevdalina N

2016-01-01

Micro- and macrovascular pathology is a frequent finding in a number of common rheumatic diseases. Secondary Raynaud's phenomenon (RP) is among the most common symptoms in systemic sclerosis and several other systemic autoimmune diseases including a broad differential diagnosis. It should be also differential from other peripheral vascular syndromes such as embolism, thrombosis, etc., some of which lead to clinical manifestation of the blue toe syndrome. The current review discusses the instrumental methods for vascular assessments. Nailfold capillaroscopy is the only method among the imaging techniques that can be used for morphological assessment of the nutritive capillaries in the nailfold area. Laser-Doppler flowmetry and laser-Doppler imaging are methods for functional assessment of microcirculation, while thermography and plethysmography reflect both blood flow in peripheral arteries and microcirculation. Doppler ultrasound and angiography visualize peripheral arteries. The choice of the appropriate instrumental method is guided by the clinical presentation. The main role of capillaroscopy is to provide differential diagnosis between primary and secondary RP. In rheumatology, capillaroscopic changes in systemic sclerosis have been recently defined as diagnostic. The appearance of abnormal capillaroscopic pattern inherits high positive predictive value for the development of a connective tissue disease that is higher than the predictive value of antinuclear antibodies. In cases of abrupt onset of peripheral ischaemia, clinical signs of critical ischaemia, unilateral or lower limb involvement, Doppler ultrasound and angiography are indicated. The most common causes for such clinical picture that may be referred to rheumatologic consultation are the antiphospholipid syndrome, mimickers of vasculitides such as atherosclerosis with cholesterol emboli, and neoplasms.

Fast and robust standard-deviation-based method for bulk motion compensation in phase-based functional OCT.

PubMed

Wei, Xiang; Camino, Acner; Pi, Shaohua; Cepurna, William; Huang, David; Morrison, John C; Jia, Yali

2018-05-01

Phase-based optical coherence tomography (OCT), such as OCT angiography (OCTA) and Doppler OCT, is sensitive to the confounding phase shift introduced by subject bulk motion. Traditional bulk motion compensation methods are limited by their accuracy and computing cost-effectiveness. In this Letter, to the best of our knowledge, we present a novel bulk motion compensation method for phase-based functional OCT. Bulk motion associated phase shift can be directly derived by solving its equation using a standard deviation of phase-based OCTA and Doppler OCT flow signals. This method was evaluated on rodent retinal images acquired by a prototype visible light OCT and human retinal images acquired by a commercial system. The image quality and computational speed were significantly improved, compared to two conventional phase compensation methods.

Doppler tomography and photometry of the cataclysmic variable 1RXS J064434.5+334451

NASA Astrophysics Data System (ADS)

Hernández Santisteban, J. V.; Echevarría, J.; Michel, R.; Costero, R.

2017-01-01

We have obtained simultaneous photometric and spectroscopic observations of the cataclysmic variable 1RXS J064434.5+334451. We have calibrated the spectra for slit losses using simultaneous photometry, allowing us to construct reliable Doppler images from Hα and He II 4686-Å emission lines. We have improved the ephemeris of the object based on new photometric eclipse timings, obtaining HJD = 245 3403.759 533 + 0.269 374 46E. Some eclipses present a clear internal structure, which we attribute to a central He II emission region surrounding the white dwarf, a finding supported by Doppler tomography. This indicates that the system has a large inclination angle I = 78 ± 2°. We have also analysed the radial velocity curve from the emission lines to measure its semi-amplitude, K1, from Hα and He II 4686 and derive the masses of the components M1 = 0.82 ± 0.06 M⊙, M2 = 0.78 ± 0.04 M⊙ and their separation a = 2.01 ± 0.06 R⊙. The Doppler tomography and other observed features in this nova-like system strongly suggest that this is a SW Sex type system.

Single-element ultrasound transducer for combined vessel localization and ablation.

PubMed

Chen, Wen-Shiang; Shen, Che-Chou; Wang, Jen-Chieh; Ko, Chung-Ting; Liu, Hao-Li; Ho, Ming-Chih; Chen, Chiung-Nien; Yeh, Chih-Kuang

2011-04-01

This report describes a system that utilizes a single high-intensity focused ultrasound (HIFU) transducer for both the localization and ablation of arteries with internal diameters of 0.5 and 1.3 mm. In vitro and in vivo tests were performed to demonstrate both the imaging and ablation functionalities of this system. For imaging mode, pulsed acoustic waves (3 cycles for in vitro and 10 cycles for in vivo tests, 2 MPa peak pressure) were emitted from the 2-MHz HIFU transducer, and the backscattered ultrasonic signal was collected by the same transducer to calculate Doppler shifts in the target region. The maximum signal amplitude of the Doppler shift was used to determine the location of the target vessel. The operation mode was then switched to the therapeutic mode and vessel occlusion was successfully produced by high-intensity continuous HIFU waves (12 MPa) for 60 s. The system was then switched back to imaging mode for residual flow to determine the need for a second ablation treatment. The new system might be used to target and occlude unwanted vessels such as vasculature around tumors, and to help with tumor destruction. © 2011 IEEE

Application of vector analysis on study of illuminated area and Doppler characteristics of airborne pulse radar

NASA Astrophysics Data System (ADS)

Wang, Haijiang; Yang, Ling

2014-12-01

In this paper, the application of vector analysis tool in the illuminated area and the Doppler frequency distribution research for the airborne pulse radar is studied. An important feature of vector analysis is that it can closely combine the geometric ideas with algebraic calculations. Through coordinate transform, the relationship between the frame of radar antenna and the ground, under aircraft motion attitude, is derived. Under the time-space analysis, the overlap area between the footprint of radar beam and the pulse-illuminated zone is obtained. Furthermore, the Doppler frequency expression is successfully deduced. In addition, the Doppler frequency distribution is plotted finally. Using the time-space analysis results, some important parameters of a specified airborne radar system are obtained. Simultaneously, the results are applied to correct the phase error brought by attitude change in airborne synthetic aperture radar (SAR) imaging.

Tissue Doppler imaging and echo-Doppler findings associated with a mitral valve stenosis with an immobile posterior valve leaflet in a bull terrier.

PubMed

Tidholm, A; Nicolle, A P; Carlos, C; Gouni, V; Caruso, J L; Pouchelon, J L; Chetboul, V

2004-04-01

A mitral valve stenosis was diagnosed in a 2-year-old female Bull Terrier by use of two-dimensional (2-D) and M-mode echocardiography, colour-flow imaging and spectral Doppler examinations. Tissue Doppler Imaging was also performed to assess the segmental radial myocardial motion. The mitral valve stenosis was characterized by a decreased mitral orifice area/left ventricle area ratio (0.14), an increased early diastolic flow velocity (E wave = 1.9 m/s), a prolonged pressure half-time (106 ms) and a decreased E-F slope (4.5 cm/s) on pulsed-wave Doppler examination. This mitral stenosis was associated with an immobile posterior leaflet, as seen on 2-D and M-mode echocardiography. Immobility of the posterior mitral leaflet is considered to be a rare finding in humans and, to our knowledge, has not been precisely documented in dogs with mitral valve stenosis.

Complex phase error and motion estimation in synthetic aperture radar imaging

NASA Astrophysics Data System (ADS)

Soumekh, M.; Yang, H.

1991-06-01

Attention is given to a SAR wave equation-based system model that accurately represents the interaction of the impinging radar signal with the target to be imaged. The model is used to estimate the complex phase error across the synthesized aperture from the measured corrupted SAR data by combining the two wave equation models governing the collected SAR data at two temporal frequencies of the radar signal. The SAR system model shows that the motion of an object in a static scene results in coupled Doppler shifts in both the temporal frequency domain and the spatial frequency domain of the synthetic aperture. The velocity of the moving object is estimated through these two Doppler shifts. It is shown that once the dynamic target's velocity is known, its reconstruction can be formulated via a squint-mode SAR geometry with parameters that depend upon the dynamic target's velocity.

In vivo endoscopic Doppler optical coherence tomography imaging of the colon

PubMed Central

Welge, Weston A.; Barton, Jennifer K.

2017-01-01

Background and Objective Colorectal cancer remains the second deadliest cancer in the United States. Several screening methods exist, however detection of small polyps remains a challenge. Optical coherence tomography has been demonstrated to be capable of detecting lesions as small as 1 mm in the mouse colon, but detection is based on measuring a doubling of the mucosa thickness. The colon microvasculature may be an attractive biomarker of early tumor development because tumor vessels are characterized by irregular structure and dysfunction. Our goal was to develop an endoscopic method of detecting and segmenting colon vessels using Doppler optical coherence tomography to enable future studies for improving early detection and development of novel chemopreventive agents. Method We conducted in vivo colon imaging in an azoxymethane (AOM)-treated mouse model of colorectal cancer using a miniature endoscope and a swept-source OCT system at 1040 nm with a 16 kHz sweep rate. We applied the Kasai autocorrelation algorithm to laterally oversampled OCT B-scans to resolve vascular flow in the mucosa and submucosa. Vessels were segmented by applying a series of image processing steps: (1) intensity thresholding, (2) two-dimensional matched filtering, and (3) histogram segmentation. Results We observed differences in the vessels sizes and spatial distribution in a mature adenoma compared to surrounding undiseased tissue and compared the results with histology. We also imaged flow in four young mice (2 AOM-treated and 2 control) showing no significant differences, which is expected so early after carcinogen exposure. We also present flow images of adenoma in a living mouse and a euthanized mouse to demonstrate that no flow is detected after euthanasia. Conclusion We present, to the best of our knowledge, the first Doppler OCT images of in vivo mouse colon collected with a fiber-based endoscope. We also describe a fast and robust image processing method for segmenting vessels in the colon. These results suggest that Doppler OCT is a promising imaging modality for vascular imaging in the colon that requires no exogenous contrast agents. PMID:27546786

Cardiovascular Imaging and Image Processing: Theory and Practice - 1975

NASA Technical Reports Server (NTRS)

Harrison, Donald C. (Editor); Sandler, Harold (Editor); Miller, Harry A. (Editor); Hood, Manley J. (Editor); Purser, Paul E. (Editor); Schmidt, Gene (Editor)

1975-01-01

Ultrasonography was examined in regard to the developmental highlights and present applicatons of cardiac ultrasound. Doppler ultrasonic techniques and the technology of miniature acoustic element arrays were reported. X-ray angiography was discussed with special considerations on quantitative three dimensional dynamic imaging of structure and function of the cardiopulmonary and circulatory systems in all regions of the body. Nuclear cardiography and scintigraphy, three--dimensional imaging of the myocardium with isotopes, and the commercialization of the echocardioscope were studied.

High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes.

PubMed

Walk, Elyse L; McLaughlin, Sarah L; Weed, Scott A

2015-07-25

High-frequency ultrasound (HFUS) is widely employed as a non-invasive method for imaging internal anatomic structures in experimental small animal systems. HFUS has the ability to detect structures as small as 30 µm, a property that has been utilized for visualizing superficial lymph nodes in rodents in brightness (B)-mode. Combining power Doppler with B-mode imaging allows for measuring circulatory blood flow within lymph nodes and other organs. While HFUS has been utilized for lymph node imaging in a number of mouse  model systems, a detailed protocol describing HFUS imaging and characterization of the cervical lymph nodes in mice has not been reported. Here, we show that HFUS can be adapted to detect and characterize cervical lymph nodes in mice. Combined B-mode and power Doppler imaging can be used to detect increases in blood flow in immunologically-enlarged cervical nodes. We also describe the use of B-mode imaging to conduct fine needle biopsies of cervical lymph nodes to retrieve lymph tissue for histological  analysis. Finally, software-aided steps are described to calculate changes in lymph node volume and to visualize changes in lymph node morphology following image reconstruction. The ability to visually monitor changes in cervical lymph node biology over time provides a simple and powerful technique for the non-invasive monitoring of cervical lymph node alterations in preclinical mouse models of oral cavity disease.

Real-Time Color-Doppler Guidance of HIFU for the Selective Avoidance or Occlusion of Blood Vessels

NASA Astrophysics Data System (ADS)

Rabkin, Brian A.; Zderic, Vesna; Vaezy, Shahram

2005-03-01

High-intensity focused ultrasound (HIFU) has been shown to effectively occlude blood vessels deep within tissue. The objective of the current study was to synchronize HIFU and color-Doppler ultrasound (US) for the real-time visualization of flow within blood vessels during HIFU treatment. The excitation of the HIFU was synchronized with the color-Doppler imager by collecting the excitation pulses of one of the elements of either a curved array intracavitary (C 9-5) or an intraoperative (CL 10-5) imaging probe. The collected excitation pulse was converted into a TTL-high pulse, which was delayed and gated to time the excitation duration and location of the HIFU pulse with respect to each imaging frame. The single pulse was used to drive a 3.2 MHz concave HIFU transducer (focal length of 3.5 cm, f-number 1) while the US imager was not collecting RF signals from the treatment region of the US image. The feasibility of the system was demonstrated in vivo by the selective ablation of tissue adjacent to, or the occlusion of, large vessels (including the femoral artery) both transcutaneously and interoperatively in the rabbit and pig. For the occlusion of vessels, the HIFU focus was placed immediately distal (with respect to the transducer) to the vessel at a depth of 2-2.5 cm. HIFU was applied at in situ intensities of 1000-2000 W/cm2, at a duty cycle of 50-75%, and a HIFU pulse repetition frequency (set by the US image frame rate) of 6-18 Hz. During each HIFU exposure, the HIFU pulse resulted in color interference bands running vertically within the color-Doppler window. Through the synchronization of the US imager with the HIFU excitation, the location and duration of the interference bands were set outside the treatment region within each image frame. This provided the operator with a clear view of the HIFU treatment site during therapy. Gross assessment showed necrosis of the tissue surrounding the HIFU treated vessel and occlusion of vessels up to 4 mm in diameter after a 30 s HIFU exposure. We have developed a method of synchronizing pulsed HIFU with color-Doppler US imaging for the real-time visualization of flow within blood vessels during HIFU therapy. This provides a means of guiding HIFU therapy for the detection and occlusion of deep vessels, or the selective ablation of tissue surrounding the vessels without vascular occlusion.

Scleroderma in children: an update.

PubMed

Zulian, Francesco; Cuffaro, Giorgio; Sperotto, Francesca

2013-09-01

Scleroderma, in its localized and systemic presentation, represents the third most frequent rheumatic condition in childhood after juvenile idiopathic arthritis and systemic lupus erythematosus. Early diagnosis, appropriate assessment and effective treatment are crucial to improve the long-term outcome. Recent studies, concerning histopathology and clinical associations with other conditions, open new horizons on the etiopathogenesis of scleroderma. New developments have been also reached in the field of outcome measures. In juvenile localized scleroderma (JLS), new techniques such as Doppler and laser Doppler imaging have shown their usefulness for the daily monitoring of the patients. In juvenile systemic sclerosis (JSSc), a new severity score has been developed and needs to be validated in future trials. Finally, a randomized, double-blind controlled trial, a multicenter consensus statement and long-term follow-up studies have confirmed the important role of methotrexate (MTX) for the treatment of JLS. Studies over recent years highlighted the role of imaging as outcome measures for JLS and introduced a severity score for JSSc. New studies on MTX confirmed its important role for the treatment of JLS.

Imaging and characterizing shear wave and shear modulus under orthogonal acoustic radiation force excitation using OCT Doppler variance method.

PubMed

Zhu, Jiang; Qu, Yueqiao; Ma, Teng; Li, Rui; Du, Yongzhao; Huang, Shenghai; Shung, K Kirk; Zhou, Qifa; Chen, Zhongping

2015-05-01

We report on a novel acoustic radiation force orthogonal excitation optical coherence elastography (ARFOE-OCE) technique for imaging shear wave and quantifying shear modulus under orthogonal acoustic radiation force (ARF) excitation using the optical coherence tomography (OCT) Doppler variance method. The ARF perpendicular to the OCT beam is produced by a remote ultrasonic transducer. A shear wave induced by ARF excitation propagates parallel to the OCT beam. The OCT Doppler variance method, which is sensitive to the transverse vibration, is used to measure the ARF-induced vibration. For analysis of the shear modulus, the Doppler variance method is utilized to visualize shear wave propagation instead of Doppler OCT method, and the propagation velocity of the shear wave is measured at different depths of one location with the M scan. In order to quantify shear modulus beyond the OCT imaging depth, we move ARF to a deeper layer at a known step and measure the time delay of the shear wave propagating to the same OCT imaging depth. We also quantitatively map the shear modulus of a cross-section in a tissue-equivalent phantom after employing the B scan.

Automatic extraction of disease-specific features from Doppler images

NASA Astrophysics Data System (ADS)

Negahdar, Mohammadreza; Moradi, Mehdi; Parajuli, Nripesh; Syeda-Mahmood, Tanveer

2017-03-01

Flow Doppler imaging is widely used by clinicians to detect diseases of the valves. In particular, continuous wave (CW) Doppler mode scan is routinely done during echocardiography and shows Doppler signal traces over multiple heart cycles. Traditionally, echocardiographers have manually traced such velocity envelopes to extract measurements such as decay time and pressure gradient which are then matched to normal and abnormal values based on clinical guidelines. In this paper, we present a fully automatic approach to deriving these measurements for aortic stenosis retrospectively from echocardiography videos. Comparison of our method with measurements made by echocardiographers shows large agreement as well as identification of new cases missed by echocardiographers.

Tissue Doppler Imaging in the evaluation of abdominal aortic pulsatility: a useful tool for the neonatologist.

PubMed

Valerio, Enrico; Grison, Alessandra; Capretta, Anna; Golin, Rosanna; Ferrarese, Paola; Bellettato, Massimo

2017-03-01

Sonographic cardiac evaluation of newborns with suspected aortic coarctation (AoC) should tend to demonstrate a good phasic and pulsatile flow and the absence of pressure gradient along a normally conformed aortic arch from the modified left parasternal and suprasternal echocardiographic views; these findings, however, may not necessarily rule out a more distal coarctation in the descending aorta. For this reason, the sonographic exam of newborns with suspected AoC should always include a Doppler evaluation of abdominal aortic blood flow from the subcostal view. Occasionally, however, a clearly pulsatile Doppler flow trace in abdominal aorta may be difficult to obtain due to the bad insonation angle existing between the probe and the vessel. In such suboptimal ultrasonic alignment situation, the use of Tissue Doppler Imaging instead of classic Doppler flow imaging may reveal a preserved aortic pulsatility by sampling the aortic wall motion induced by normal flow. We propose to take advantage of the TDI pattern as a surrogate of a normal pulsatile Doppler flow trace in abdominal aorta when the latter is difficult to obtain due to malalignment with the insonated vessel.

Measurement of retinal blood flow in the rat by combining Doppler Fourier-domain optical coherence tomography with fundus imaging

NASA Astrophysics Data System (ADS)

Werkmeister, René M.; Vietauer, Martin; Knopf, Corinna; Fürnsinn, Clemens; Leitgeb, Rainer A.; Reitsamer, Herbert; Gröschl, Martin; Garhöfer, Gerhard; Vilser, Walthard; Schmetterer, Leopold

2014-10-01

A wide variety of ocular diseases are associated with abnormalities in ocular circulation. As such, there is considerable interest in techniques for quantifying retinal blood flow, among which Doppler optical coherence tomography (OCT) may be the most promising. We present an approach to measure retinal blood flow in the rat using a new optical system that combines the measurement of blood flow velocities via Doppler Fourier-domain optical coherence tomography and the measurement of vessel diameters using a fundus camera-based technique. Relying on fundus images for extraction of retinal vessel diameters instead of OCT images improves the reliability of the technique. The system was operated with an 841-nm superluminescent diode and a charge-coupled device camera that could be operated at a line rate of 20 kHz. We show that the system is capable of quantifying the response of 100% oxygen breathing on the retinal blood flow. In six rats, we observed a decrease in retinal vessel diameters of 13.2% and a decrease in retinal blood velocity of 42.6%, leading to a decrease in retinal blood flow of 56.7%. Furthermore, in four rats, the response of retinal blood flow during stimulation with diffuse flicker light was assessed. Retinal vessel diameter and blood velocity increased by 3.4% and 28.1%, respectively, leading to a relative increase in blood flow of 36.2%;. The presented technique shows much promise to quantify early changes in retinal blood flow during provocation with various stimuli in rodent models of ocular diseases in rats.

Application of a new laser Doppler imaging system in planning and monitoring of surgical flaps

NASA Astrophysics Data System (ADS)

Schlosser, Stefan; Wirth, Raphael; Plock, Jan A.; Serov, Alexandre; Banic, Andrej; Erni, Dominique

2010-05-01

There is a demand for technologies able to assess the perfusion of surgical flaps quantitatively and reliably to avoid ischemic complications. The aim of this study is to test a new high-speed high-definition laser Doppler imaging (LDI) system (FluxEXPLORER, Microvascular Imaging, Lausanne, Switzerland) in terms of preoperative mapping of the vascular supply (perforator vessels) and postoperative flow monitoring. The FluxEXPLORER performs perfusion mapping of an area 9×9 cm with a resolution of 256×256 pixels within 6 s in high-definition imaging mode. The sensitivity and predictability to localize perforators is expressed by the coincidence of preoperatively assessed LDI high flow spots with intraoperatively verified perforators in nine patients. 18 free flaps are monitored before, during, and after total ischemia. 63% of all verified perforators correspond to a high flow spot, and 38% of all high flow spots correspond to a verified perforator (positive predictive value). All perfused flaps reveal a value of above 221 perfusion units (PUs), and all values obtained in the ischemic flaps are beneath 187 PU. In summary, we conclude that the present LDI system can serve as a reliable, fast, and easy-to-handle tool to detect ischemia in free flaps, whereas perforator vessels cannot be detected appropriately.

Dense concentric circle scanning protocol for measuring pulsatile retinal blood flow in rats with Doppler optical coherence tomography

NASA Astrophysics Data System (ADS)

Tan, Bingyao; Hosseinaee, Zohreh; Bizheva, Kostadinka

2017-11-01

The variability in the spatial orientation of retinal blood vessels near the optic nerve head (ONH) results in imprecision of the measured Doppler angle and therefore the pulsatile blood flow (BF), when those parameters are evaluated using Doppler OCT imaging protocols based on dual-concentric circular scans. Here, we utilized a dense concentric circle scanning protocol and evaluated its precision for measuring pulsatile retinal BF in rats for different numbers of the circular scans. An spectral domain optical coherence tomography (SD-OCT) system operating in the 1060-nm spectral range with image acquisition rate of 47,000 A-scans/s was used to acquire concentric circular scans centered at the rat's ONH, with diameters ranging from 0.8 to 1.0 mm. A custom, automatic blood vessel segmentation algorithm was used to track the spatial orientation of the retinal blood vessels in three dimensions, evaluate the spatially dependent Doppler angle and calculate more accurately the axial BF for each major retinal blood vessel. Metrics such as retinal BF, pulsatility index, and resistance index were evaluated for each and all of the major retinal blood vessels. The performance of the proposed dense concentric circle scanning protocols was compared with that of the dual-circle scanning protocol. Results showed a 3.8±2.2 deg difference in the Doppler angle calculation between the two approaches, which resulted in ˜7% difference in the calculated retinal BF.

Laser Doppler imaging of cutaneous blood flow through transparent face masks: a necessary preamble to computer-controlled rapid prototyping fabrication with submillimeter precision.

PubMed

Allely, Rebekah R; Van-Buendia, Lan B; Jeng, James C; White, Patricia; Wu, Jingshu; Niszczak, Jonathan; Jordan, Marion H

2008-01-01

A paradigm shift in management of postburn facial scarring is lurking "just beneath the waves" with the widespread availability of two recent technologies: precise three-dimensional scanning/digitizing of complex surfaces and computer-controlled rapid prototyping three-dimensional "printers". Laser Doppler imaging may be the sensible method to track the scar hyperemia that should form the basis of assessing progress and directing incremental changes in the digitized topographical face mask "prescription". The purpose of this study was to establish feasibility of detecting perfusion through transparent face masks using the Laser Doppler Imaging scanner. Laser Doppler images of perfusion were obtained at multiple facial regions on five uninjured staff members. Images were obtained without a mask, followed by images with a loose fitting mask with and without a silicone liner, and then with a tight fitting mask with and without a silicone liner. Right and left oblique images, in addition to the frontal images, were used to overcome unobtainable measurements at the extremes of face mask curvature. General linear model, mixed model, and t tests were used for data analysis. Three hundred seventy-five measurements were used for analysis, with a mean perfusion unit of 299 and pixel validity of 97%. The effect of face mask pressure with and without the silicone liner was readily quantified with significant changes in mean cutaneous blood flow (P < .5). High valid pixel rate laser Doppler imager flow data can be obtained through transparent face masks. Perfusion decreases with the application of pressure and with silicone. Every participant measured differently in perfusion units; however, consistent perfusion patterns in the face were observed.

LASER APPLICATIONS AND OTHER TOPICS IN QUANTUM ELECTRONICS: Laser Doppler visualisation of the velocity field by excluding the influence of multiparticle scattering

NASA Astrophysics Data System (ADS)

Dubnishchev, Yu N.; Chugui, Yu V.; Kompenhans, J.

2009-10-01

The method of laser Doppler visualisation and measurement of the velocity field in gas and liquid flows by suppressing the influence of multiparticle scattering is discussed. The cross section of the flow under study is illuminated by a laser beam transformed by an anamorphic optical system into a laser sheet. The effect of multiparticle scattering is eliminated by obtaining differential combinations of frequency-demodulated images of the laser sheet in different regions of the angular spectrum of scattered light.

Imaging doppler lidar for wind turbine wake profiling

DOEpatents

Bossert, David J.

2015-11-19

An imaging Doppler lidar (IDL) enables the measurement of the velocity distribution of a large volume, in parallel, and at high spatial resolution in the wake of a wind turbine. Because the IDL is non-scanning, it can be orders of magnitude faster than conventional coherent lidar approaches. Scattering can be obtained from naturally occurring aerosol particles. Furthermore, the wind velocity can be measured directly from Doppler shifts of the laser light, so the measurement can be accomplished at large standoff and at wide fields-of-view.

NO PLIF Imaging in the CUBRC 48-inch Shock Tunnel

DTIC Science & Technology

2012-01-01

Exp Fluids (2012) 53:1637-1646 OOI 10.1007/s00348-012-1381-6 RESEARCH ARTICLE NO PLIF imaging in the CUBRC 48-inch shock tunnel N. Jiang· J...Center’s (CUBRC) 48-inch Mach 9 hypervelocity shock tunnel using a pulse burst laser-based high frame rate imaging system. Sequences of up to ten images...2002) have been performed in the Australia National University’s T2 free- piston shock tunnel . More recently, two-component Doppler- shift-based

Semi-automation of Doppler Spectrum Image Analysis for Grading Aortic Valve Stenosis Severity.

PubMed

Niakšu, O; Balčiunaitė, G; Kizlaitis, R J; Treigys, P

2016-01-01

Doppler echocardiography analysis has become a golden standard in the modern diagnosis of heart diseases. In this paper, we propose a set of techniques for semi-automated parameter extraction for aortic valve stenosis severity grading. The main objectives of the study is to create echocardiography image processing techniques, which minimize manual image processing work of clinicians and leads to reduced human error rates. Aortic valve and left ventricle output tract spectrogram images have been processed and analyzed. A novel method was developed to trace systoles and to extract diagnostic relevant features. The results of the introduced method have been compared to the findings of the participating cardiologists. The experimental results showed the accuracy of the proposed method is comparable to the manual measurement performed by medical professionals. Linear regression analysis of the calculated parameters and the measurements manually obtained by the cardiologists resulted in the strongly correlated values: peak systolic velocity's and mean pressure gradient's R2 both equal to 0.99, their means' differences equal to 0.02 m/s and 4.09 mmHg, respectively, and aortic valve area's R2 of 0.89 with the two methods means' difference of 0.19 mm. The introduced Doppler echocardiography images processing method can be used as a computer-aided assistance in the aortic valve stenosis diagnostics. In our future work, we intend to improve precision of left ventricular outflow tract spectrogram measurements and apply data mining methods to propose a clinical decision support system for diagnosing aortic valve stenosis.

The Surface of V410 Tauri

NASA Astrophysics Data System (ADS)

Rice, J. B.; Strassmeier, K. G.; Kopf, M.

2011-02-01

We present Doppler images of the weak-lined T Tauri star V410 Tau obtained with two different Doppler-imaging codes. The images are consistent and show a cool extended spot, symmetric about the pole, at a temperature approximately 750 K below the average photospheric value. Smaller cool spots are found fairly uniformly distributed at latitudes below the polar cap with temperatures about 450 K below the average photospheric temperature. Resolution on the stellar surface is limited to about 7° of arc, so structure within these spots is not visible. Also at lower latitudes are hotter features with temperatures up to 1000 K above the photosphere. A trial Doppler image using a TiO molecular feature reproduced the cool polar cap at a temperature about 100 K below the value from the atomic line images. The equatorial features, however, were not properly reproduced since Doppler imaging relies on information in the wings of lines for reconstructing equatorial features, and for V410 Tau these molecular band lines overlap. In 1993, V410 Tau had a large photometric amplitude resulting from the concentration of cool spots on the hemisphere of the star visible at phase 0°, a phenomenon known as preferred longitude. In contrast, the small photometric amplitude observed currently is due to a strong symmetric polar spot and the uniform distribution in longitude of equatorial cool and warm spots. This redistribution of surface features may be the beginning of a slow "flip-flop" for V410 Tau where spot locations alternate between preferred longitudes. Flare events linked to two of the hotter spots in the Doppler image were observed.

A New Active Cavitation Mapping Technique for Pulsed HIFU Applications – Bubble Doppler

PubMed Central

Li, Tong; Khokhlova, Tatiana; Sapozhnikov, Oleg; Hwang, Joo Ha; Sapozhnikov, Oleg; O’Donnell, Matthew

2015-01-01

In this work, a new active cavitation mapping technique for pulsed high-intensity focused ultrasound (pHIFU) applications termed bubble Doppler is proposed and its feasibility tested in tissue-mimicking gel phantoms. pHIFU therapy uses short pulses, delivered at low pulse repetition frequency, to cause transient bubble activity that has been shown to enhance drug and gene delivery to tissues. The current gold standard for detecting and monitoring cavitation activity during pHIFU treatments is passive cavitation detection (PCD), which provides minimal information on the spatial distribution of the bubbles. B-mode imaging can detect hyperecho formation, but has very limited sensitivity, especially to small, transient microbubbles. The bubble Doppler method proposed here is based on a fusion of the adaptations of three Doppler techniques that had been previously developed for imaging of ultrasound contrast agents – color Doppler, pulse inversion Doppler, and decorrelation Doppler. Doppler ensemble pulses were interleaved with therapeutic pHIFU pulses using three different pulse sequences and standard Doppler processing was applied to the received echoes. The information yielded by each of the techniques on the distribution and characteristics of pHIFU-induced cavitation bubbles was evaluated separately, and found to be complementary. The unified approach - bubble Doppler – was then proposed to both spatially map the presence of transient bubbles and to estimate their sizes and the degree of nonlinearity. PMID:25265178

Technical Note: A new phantom design for routine testing of Doppler ultrasound.

PubMed

Grice, J V; Pickens, D R; Price, R R

2016-07-01

The objective of this project is to demonstrate the principle and operation for a simple, inexpensive, and highly portable Doppler ultrasound quality assurance (QA) phantom intended for routine QA testing. A prototype phantom has been designed, fabricated, and evaluated. The phantom described here is powered by gravity alone, requires no external equipment for operation, and produces a stable fluid velocity useful for quality assurance. Many commercially available Doppler ultrasound testing systems can suffer from issues such as a lengthy setup, prohibitive cost, nonportable size, or difficulty in use. This new phantom design aims to address some of these problems and create a phantom appropriate for assessing Doppler ultrasound stability. The phantom was fabricated using a 3D printer. The basic design of the phantom is to provide gravity-powered flow of a Doppler fluid between two reservoirs. The printed components were connected with latex tubing and then seated in a tissue mimicking gel. Spectral Doppler waveforms were sampled to evaluate variations in the data, and the phantom was evaluated using high frame rate video to find an alternate measure of mean fluid velocity flowing in the phantom. The current system design maintains stable flow from one reservoir to the other for approximately 7 s. Color Doppler imaging of the phantom was found to be qualitatively consistent with laminar flow. Using pulsed spectral Doppler, the average fluid velocity from a sample volume approximately centered in the synthetic vessel was measured to be 56 cm/s with a standard deviation of 3.2 cm/s across 118 measurements. An independent measure of the average fluid velocity was measured to be 51.9 cm/s with a standard deviation of 0.7 cm/s over 4 measurements. The developed phantom provides stable fluid flow useful for frequent clinical Doppler ultrasound testing and attempts to address several obstacles facing Doppler phantom testing. Such an ultrasound phantom can make routine testing more approachable for institutions that wish to initiate a Doppler QA program or complement a previously existing QA program.

Seeing Which Way the Wind Blows: New Doppler Radar Takes Flight on This Summer's HS3 Mission

NASA Image and Video Library

2017-12-08

Most aircraft carrying Doppler radar look like they’ve grown a tail, developed a dorsal fin, or sprouted a giant pancake on their backs. But when the unmanned Global Hawk carries a radar system this summer, its cargo will be hard to see. The autonomous and compact High-altitude Imaging Wind and Rain Profiler, or HIWRAP, a dual-frequency conical-scanning Doppler radar, will hang under the aircraft’s belly as it flies above hurricanes to measure wind and rain and to test a new method for retrieving wind data. HIWRAP is one of the instruments that will fly in this summer's mission to explore Atlantic Ocean hurricanes. NASA's Hurricane and Severe Storm Sentinel, or HS3, airborne mission will investigate tropical cyclones using a number of instruments and two Global Hawks. The HS3 mission will operate between Aug. 20 and Sept. 23. Read more: 1.usa.gov/18TYPt7 NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Clinical, echocardiographic, and Doppler imaging characteristics of mitral valve stenosis in two dogs.

PubMed

Fox, P R; Miller, M W; Liu, S K

1992-11-15

Mitral stenosis was diagnosed noninvasively by echocardiography and Doppler imaging in 2 Bull Terriers. Two-dimensional echocardiography revealed severe atrial and moderate left ventricular dilatation; severely reduced mitral valve opening excursion; doming of the cranial mitral valve leaflet into the left ventricle during diastole; thickened, nodular cranial mitral valve leaflets; and reduced mitral valve orifice. M-mode echocardiographic findings additionally indicated greatly diminished mitral valve E to F slope and abnormal caudal mitral valve leaflet motion. Color flow Doppler imaging revealed bright bursts of color with aliasing originating from the stenotic mitral valve orifice, extending into the left atrium during systole, and into the left atrium during diastole. Spectral Doppler recordings revealed transvalvular mitral valve gradients and prolonged pressure half-times. Necropsy performed on 1 dog revealed extremely thickened, nodular, and stiff mitral valves with short, thickened, and fused chordae tendineae. The diagnosis of mitral valve stenosis was easily facilitated with diagnostic ultrasonography.

Multi-Component, Multi-Point Interferometric Rayleigh/Mie Doppler Velocimeter

NASA Technical Reports Server (NTRS)

Danehy, Paul M.; Lee, Joseph W.; Bivolaru, Daniel

2012-01-01

An interferometric Rayleigh scattering system was developed to enable the measurement of multiple, orthogonal velocity components at several points within very-high-speed or high-temperature flows. The velocity of a gaseous flow can be optically measured by sending laser light into the gas flow, and then measuring the scattered light signal that is returned from matter within the flow. Scattering can arise from either gas molecules within the flow itself, known as Rayleigh scattering, or from particles within the flow, known as Mie scattering. Measuring Mie scattering is the basis of all commercial laser Doppler and particle imaging velocimetry systems, but particle seeding is problematic when measuring high-speed and high-temperature flows. The velocimeter is designed to measure the Doppler shift from only Rayleigh scattering, and does not require, but can also measure, particles within the flow. The system combines a direct-view, large-optic interferometric setup that calculates the Doppler shift from fringe patterns collected with a digital camera, and a subsystem to capture and re-circulate scattered light to maximize signal density. By measuring two orthogonal components of the velocity at multiple positions in the flow volume, the accuracy and usefulness of the flow measurement increase significantly over single or nonorthogonal component approaches.

Temporal enhancement of two-dimensional color doppler echocardiography

NASA Astrophysics Data System (ADS)

Terentjev, Alexey B.; Settlemier, Scott H.; Perrin, Douglas P.; del Nido, Pedro J.; Shturts, Igor V.; Vasilyev, Nikolay V.

2016-03-01

Two-dimensional color Doppler echocardiography is widely used for assessing blood flow inside the heart and blood vessels. Currently, frame acquisition time for this method varies from tens to hundreds of milliseconds, depending on Doppler sector parameters. This leads to low frame rates of resulting video sequences equal to tens of Hz, which is insufficient for some diagnostic purposes, especially in pediatrics. In this paper, we present a new approach for reconstruction of 2D color Doppler cardiac images, which results in the frame rate being increased to hundreds of Hz. This approach relies on a modified method of frame reordering originally applied to real-time 3D echocardiography. There are no previous publications describing application of this method to 2D Color Doppler data. The approach has been tested on several in-vivo cardiac 2D color Doppler datasets with approximate duration of 30 sec and native frame rate of 15 Hz. The resulting image sequences had equivalent frame rates to 500Hz.

High Resolution Full-Aperture ISAR Processing through Modified Doppler History Based Motion Compensation

PubMed Central

Song, Jung-Hwan; Lee, Kee-Woong; Lee, Woo-Kyung; Jung, Chul-Ho

2017-01-01

A high resolution inverse synthetic aperture radar (ISAR) technique is presented using modified Doppler history based motion compensation. To this purpose, a novel wideband ISAR system is developed that accommodates parametric processing over extended aperture length. The proposed method is derived from an ISAR-to-SAR approach that makes use of high resolution spotlight SAR and sub-aperture recombination. It is dedicated to wide aperture ISAR imaging and exhibits robust performance against unstable targets having non-linear motions. We demonstrate that the Doppler histories of the full aperture ISAR echoes from disturbed targets are efficiently retrieved with good fitting models. Experiments have been conducted on real aircraft targets and the feasibility of the full aperture ISAR processing is verified through the acquisition of high resolution ISAR imagery. PMID:28555036

Doppler Tomography and Photometry of the Cataclysmic Variable 1RXS J064434.5+334451

NASA Astrophysics Data System (ADS)

Echevarria, Juan

2015-08-01

We have obtained simultaneous photometric and spectroscopic observations of the cataclysmic variable 1RXS J064434.5+334451. We have calibrated the spectra for slit losses using the simultaneous photometry. This has been used to construct reliable Doppler images from Hα, Hβ and He II 4686 Å emission lines. We have also analyzed the radial velocity curve of the emission lines to derive its semi-amplitude, and used a co-phasing method to determine the semi-amplitude of the secondary. We have improved the ephemeris of the object based on new photometric eclipse timings to obtain HJD = 2453403.759533 + 0.26937446E. Some eclipses present a clear internal structure which we attribute to a central blob of He II emission surrounding the white dwarf, a finding supported by the Doppler Tomography. This indicates that the system has a large inclination angle i = 78o ± 2. We discuss which radial velocity semi-amplitudes indicator yields a better result for the mass ratio of the system. We derive the masses of the components: M1 = 0.76 ± 0.04 M⊙, M2 = 0.57 ± 0.04 M⊙ and their separation a = 1.92 ± 0.04R⊙ . The Doppler tomography and other observed features in this nova-like system strongly suggests that this is an SW Sex type system.

Methodological approach for the assessment of ultrasound reproducibility of cardiac structure and function: a proposal of the study group of Echocardiography of the Italian Society of Cardiology (Ultra Cardia SIC) Part I

PubMed Central

2011-01-01

When applying echo-Doppler imaging for either clinical or research purposes it is very important to select the most adequate modality/technology and choose the most reliable and reproducible measurements. Quality control is a mainstay to reduce variability among institutions and operators and must be obtained by using appropriate procedures for data acquisition, storage and interpretation of echo-Doppler data. This goal can be achieved by employing an echo core laboratory (ECL), with the responsibility for standardizing image acquisition processes (performed at the peripheral echo-labs) and analysis (by monitoring and optimizing the internal intra- and inter-reader variability of measurements). Accordingly, the Working Group of Echocardiography of the Italian Society of Cardiology decided to design standardized procedures for imaging acquisition in peripheral laboratories and reading procedures and to propose a methodological approach to assess the reproducibility of echo-Doppler parameters of cardiac structure and function by using both standard and advanced technologies. A number of cardiologists experienced in cardiac ultrasound was involved to set up an ECL available for future studies involving complex imaging or including echo-Doppler measures as primary or secondary efficacy or safety end-points. The present manuscript describes the methodology of the procedures (imaging acquisition and measurement reading) and provides the documentation of the work done so far to test the reproducibility of the different echo-Doppler modalities (standard and advanced). These procedures can be suggested for utilization also in non referall echocardiographic laboratories as an "inside" quality check, with the aim at optimizing clinical consistency of echo-Doppler data. PMID:21943283

Sonoelastography in the musculoskeletal system: Current role and future directions.

PubMed

Winn, Naomi; Lalam, Radhesh; Cassar-Pullicino, Victor

2016-11-28

Ultrasound is an essential modality within musculoskeletal imaging, with the recent addition of elastography. The elastic properties of tissues are different from the acoustic impedance used to create B mode imaging and the flow properties used within Doppler imaging, hence elastography provides a different form of tissue assessment. The current role of ultrasound elastography in the musculoskeletal system will be reviewed, in particular with reference to muscles, tendons, ligaments, joints and soft tissue tumours. The different ultrasound elastography methods currently available will be described, in particular strain elastography and shear wave elastography. Future directions of ultrasound elastography in the musculoskeletal system will also be discussed.

Hardware Development and Error Characterization for the AFIT RAIL SAR System

DTIC Science & Technology

This research is focused on updating the Air Force Institute of Technology (AFIT) Radar Instrumentation Lab (RAIL)Synthetic Aperture Radar ( SAR ...collections from a receiver in motion. Secondly, orthogonal frequency-division multiplexing (OFDM) signals are used to form ( SAR ) images in multiple...experimental and simulation configurations. This research analyses, characterizes and attempts compensation of relevant SAR image error sources, such as Doppler

Adaptive ISAR Imaging of Maneuvering Targets Based on a Modified Fourier Transform.

PubMed

Wang, Binbin; Xu, Shiyou; Wu, Wenzhen; Hu, Pengjiang; Chen, Zengping

2018-04-27

Focusing on the inverse synthetic aperture radar (ISAR) imaging of maneuvering targets, this paper presents a new imaging method which works well when the target's maneuvering is not too severe. After translational motion compensation, we describe the equivalent rotation of maneuvering targets by two variables-the relative chirp rate of the linear frequency modulated (LFM) signal and the Doppler focus shift. The first variable indicates the target's motion status, and the second one represents the possible residual error of the translational motion compensation. With them, a modified Fourier transform matrix is constructed and then used for cross-range compression. Consequently, the imaging of maneuvering is converted into a two-dimensional parameter optimization problem in which a stable and clear ISAR image is guaranteed. A gradient descent optimization scheme is employed to obtain the accurate relative chirp rate and Doppler focus shift. Moreover, we designed an efficient and robust initialization process for the gradient descent method, thus, the well-focused ISAR images of maneuvering targets can be achieved adaptively. Human intervention is not needed, and it is quite convenient for practical ISAR imaging systems. Compared to precedent imaging methods, the new method achieves better imaging quality under reasonable computational cost. Simulation results are provided to validate the effectiveness and advantages of the proposed method.

The high-resolution Doppler imager on the Upper Atmosphere Research Satellite

NASA Technical Reports Server (NTRS)

Hays, Paul B.; Abreu, Vincent J.; Dobbs, Michael E.; Gell, David A.; Grassl, Heinz J.; Skinner, Wilbert R.

1993-01-01

The high-resolution Doppler imager (HRDI) on the Upper Atmosphere Research Satellite is a triple-etalon Fabry-Perot interferometer designed to measure winds in the stratosphere, mesosphere, and lower thermosphere. Winds are determined by measuring the Doppler shifts of rotational lines of the O2 atmospheric band, which are observed in emission in the mesosphere and lower thermosphere and in absorption in the stratosphere. The interferometer has high resolution (0.05/cm), good offhand rejection, aud excellent stability. This paper provides details of the design and capabilities of the HRDI instrument.

Extended dynamic range of Doppler OCT by application of a new method to high density B-scans using a MHz FDML swept laser source (Conference Presentation)

NASA Astrophysics Data System (ADS)

Elahi, Sahar; Thrane, Lars; Rollins, Andrew M.; Jenkins, Michael W.

2017-02-01

The limited dynamic range of optical coherence tomography (OCT) Doppler velocity measurements makes it difficult to conduct experiments on samples requiring a large dynamic range without phase wrapping at high velocities or loss of sensitivity at slow velocities. Hemodynamics and wall motion undergo significant increases in velocity as the embryonic heart develops. Experimental studies indicate that altered hemodynamics in early-stage embryonic hearts can lead to congenital heart diseases (CHDs), motivating close monitoring of blood flow over several stages of development. We have built a high-speed OCT system using an FDML laser (Optores GmbH, Germany) at a sweep rate of 1.68 MHz (axial resolution - 12 μm, sensitivity - 105 dB, phase stability - 17 mrad). The speed of this OCT system allows us to acquire high-density B-scans to obtain an extended velocity dynamic range without sacrificing the frame rate (100 Hz). The extended dynamic range within a frame is achieved by varying the A-scan interval at which the phase difference is found, enabling detection of velocities ranging from tens of microns per second to hundreds of millimeters per second. The extra lines in a frame can also be utilized to improve the structural and Doppler images via complex averaging. In structural images where the presence of blood causes additional scattering, complex averaging helps retrieve features located deeper in the tissue. Moreover, high-density frames can be registered to 4D volumes to determine the orthogonal direction of flow for calculating shear stress as well as estimating the cardiac output. In conclusion, high density B-scans acquired by our high-speed OCT system enable image enhancement and direct measurement of biological parameters in cohort studies.

High quality optical microangiography of ocular microcirculation and measurement of total retinal blood flow in mouse eye

NASA Astrophysics Data System (ADS)

Zhi, Zhongwei; Yin, Xin; Dziennis, Suzan; Alpers, Charles E.; Wang, Ruikang K.

2013-03-01

Visualization and measurement of retinal blood flow (RBF) is important to the diagnosis and management of different eye diseases, including diabetic retinopathy. Optical microangiography (OMAG) is developed for generating 3D dynamic microcirculation image and later refined into ultra-high sensitive OMAG (UHS-OMAG) for true capillary vessels imaging. Here, we present the application of OMAG imaging technique for visualization of depth-resolved vascular network within retina and choroid as well as measurement of total retinal blood flow in mice. A fast speed spectral domain OCT imaging system at 820nm with a line scan rate of 140 kHz was developed to image mouse posterior eye. By applying UHS-OMAG scanning protocol and processing algorithm, we achieved true capillary level imaging of retina and choroid vasculature in mouse eye. The vascular pattern within different retinal layers and choroid was presented. An en face Doppler OCT approach [1] without knowing Doppler angle was adopted for the measurement of total retinal blood flow. The axial blood flow velocity is measured in an en face plane by raster scanning and the flow is calculated by integrating over the vessel area of the central retinal artery.

Screening for stroke in sickle cell anemia: comparison of transcranial Doppler imaging and nonimaging US techniques.

PubMed

Neish, Ariane S; Blews, David E; Simms, Catherine A; Merritt, Robert K; Spinks, Alice J

2002-03-01

To determine whether criteria for screening patients with sickle cell anemia for stroke established with a nonimaging transcranial Doppler ultrasonographic (US) technique are applicable to studies performed with a transcranial Doppler US imaging technique. One hundred sixty-eight examinations in 66 children were performed for sickle cell stroke screening. Children were examined with nonimaging and imaging transcranial Doppler US techniques on the same day, for a total of 84 paired examinations. The time-averaged maximum mean velocity (V(mean)) and resistive index (RI) were calculated in the middle cerebral arteries, bifurcations of the distal internal carotid arteries, distal internal carotid arteries, anterior cerebral arteries, posterior cerebral arteries, and basilar arteries. The maximum systolic velocity (V(max)) was evaluated in the distal internal carotid arteries and middle cerebral arteries. V(mean), V(max), and RI measurements were subjected to repeated-measures multivariate analysis of covariance, and the Pearson product moment correlation was used for middle cerebral artery velocity, age, and hemoglobin. V(mean) measurements obtained with nonimaging and imaging techniques varied substantially for the bifurcation of the distal internal carotid artery, the posterior cerebral artery, and the basilar artery. Substantial differences were found in RIs for every vessel. Examination time was shorter with the nonimaging technique. V(mean) measurements in the middle cerebral artery, distal internal carotid artery, and anterior cerebral artery did not vary substantially between nonimaging and imaging transcranial Doppler US. RI data did not yield comparable measurements.

Real-time microstructural and functional imaging and image processing in optical coherence tomography

NASA Astrophysics Data System (ADS)

Westphal, Volker

Optical Coherence Tomography (OCT) is a noninvasive optical imaging technique that allows high-resolution cross-sectional imaging of tissue microstructure, achieving a spatial resolution of about 10 mum. OCT is similar to B-mode ultrasound (US) except that it uses infrared light instead of ultrasound. In contrast to US, no coupling gel is needed, simplifying the image acquisition. Furthermore, the fiber optic implementation of OCT is compatible with endoscopes. In recent years, the transition from slow imaging, bench-top systems to real-time clinical systems has been under way. This has lead to a variety of applications, namely in ophthalmology, gastroenterology, dermatology and cardiology. First, this dissertation will demonstrate that OCT is capable of imaging and differentiating clinically relevant tissue structures in the gastrointestinal tract. A careful in vitro correlation study between endoscopic OCT images and corresponding histological slides was performed. Besides structural imaging, OCT systems were further developed for functional imaging, as for example to visualize blood flow. Previously, imaging flow in small vessels in real-time was not possible. For this research, a new processing scheme similar to real-time Doppler in US was introduced. It was implemented in dedicated hardware to allow real-time acquisition and overlayed display of blood flow in vivo. A sensitivity of 0.5mm/s was achieved. Optical coherence microscopy (OCM) is a variation of OCT, improving the resolution even further to a few micrometers. Advances made in the OCT scan engine for the Doppler setup enabled real-time imaging in vivo with OCM. In order to generate geometrical correct images for all the previous applications in real-time, extensive image processing algorithms were developed. Algorithms for correction of distortions due to non-telecentric scanning, nonlinear scan mirror movements, and refraction were developed and demonstrated. This has led to interesting new applications, as for example in imaging of the anterior segment of the eye.

Holographic motion picture camera with Doppler shift compensation

NASA Technical Reports Server (NTRS)

Kurtz, R. L. (Inventor)

1976-01-01

A holographic motion picture camera is reported for producing three dimensional images by employing an elliptical optical system. There is provided in one of the beam paths (the object or reference beam path) a motion compensator which enables the camera to photograph faster moving objects.

Listening to speech recruits specific tongue motor synergies as revealed by transcranial magnetic stimulation and tissue-Doppler ultrasound imaging

PubMed Central

D'Ausilio, A.; Maffongelli, L.; Bartoli, E.; Campanella, M.; Ferrari, E.; Berry, J.; Fadiga, L.

2014-01-01

The activation of listener's motor system during speech processing was first demonstrated by the enhancement of electromyographic tongue potentials as evoked by single-pulse transcranial magnetic stimulation (TMS) over tongue motor cortex. This technique is, however, technically challenging and enables only a rather coarse measurement of this motor mirroring. Here, we applied TMS to listeners’ tongue motor area in association with ultrasound tissue Doppler imaging to describe fine-grained tongue kinematic synergies evoked by passive listening to speech. Subjects listened to syllables requiring different patterns of dorso-ventral and antero-posterior movements (/ki/, /ko/, /ti/, /to/). Results show that passive listening to speech sounds evokes a pattern of motor synergies mirroring those occurring during speech production. Moreover, mirror motor synergies were more evident in those subjects showing good performances in discriminating speech in noise demonstrating a role of the speech-related mirror system in feed-forward processing the speaker's ongoing motor plan. PMID:24778384

Chromospherically active stars. III - HD 26337 = EI Eri: An RS CVn candidate for the Doppler-imaging technique

NASA Technical Reports Server (NTRS)

Fekel, Francis C.; Quigley, Robert; Gillies, Kim; Africano, John L.

1987-01-01

Spectroscopic observations of the chromospherically active G5 IV single-lined binary HD 26337 = EI Eri are presented. An orbital period of 1.94722 days is found for the star. It has moderately strong Ca II H and K emission and strong ultraviolet emission features, while H-alpha is a weak absorption feature that is variable in strength. The inclination of the system is 46 + or - 12 deg, and the unseen secondary is probably a late K or early M dwarf. The v sin i of the primary is 50 + or - 3 km/s, resulting in a minimum radius of 1.9 + or - 0.1 solar radius. The star is within the required limits for Doppler imaging. The primary is close to filling its Roche lobe, resulting in a strong constraint that the mass ratio is 2.6 or greater, with a primary mass of at least 1.4 solar mass. The distance to the system is estimated at 75 pc.

Applications of Doppler ultrasound in clinical vascular disease

NASA Technical Reports Server (NTRS)

Barnes, R. W.; Hokanson, D. E.; Sumner, D. S.; Strandness, D. E., Jr.

1975-01-01

Doppler ultrasound has become the most useful and versatile noninvasive technique for objective evaluation of clinical vascular disease. Commercially available continuous-wave instruments provide qualitative and quantitative assessment of venous and arterial disease. Pulsed Doppler ultrasound was developed to provide longitudinal and transverse cross-sectional images of the arterial lumen with a resolution approaching that of conventional X-ray techniques. Application of Doppler ultrasound in venous, peripheral arterial, and cerebrovascular diseases is reviewed.

Anthropomorphic cardiac ultrasound phantom.

PubMed

Smith, S W; Rinaldi, J E

1989-10-01

A new phantom is described which simulates the human cardiac anatomy for applications in ultrasound imaging, ultrasound Doppler, and color-flow Doppler imaging. The phantom consists of a polymer left ventricle which includes a prosthetic mitral and aortic valve and is connected to a mock circulatory loop. Aerated tap water serves as a blood simulating fluid and ultrasound contrast medium within the circulatory loop. The left ventricle is housed in a Lexan ultrasound visualization chamber which includes ultrasound viewing ports and acoustic absorbers. A piston pump connected to the visualization chamber by a single port pumps degassed water within the chamber which in turn pumps the left ventricle. Real-time ultrasound images and Doppler studies measure flow patterns through the valves and within the left ventricle.

Color doppler in clinical cardiology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duncan, W.J.

1987-01-01

A presentation of color doppler, which enables physicians to pinpoint problems and develop effective treatment. State-of-the-art illustrations and layout, with color images and explanatory text are included.

Preliminary measurements of the edge magnetic field pitch from 2-D Doppler backscattering in MAST and NSTX-U (invited)

NASA Astrophysics Data System (ADS)

Vann, R. G. L.; Brunner, K. J.; Ellis, R.; Taylor, G.; Thomas, D. A.

2016-11-01

The Synthetic Aperture Microwave Imaging (SAMI) system is a novel diagnostic consisting of an array of 8 independently phased antennas. At any one time, SAMI operates at one of the 16 frequencies in the range 10-34.5 GHz. The imaging beam is steered in software post-shot to create a picture of the entire emission surface. In SAMI's active probing mode of operation, the plasma edge is illuminated with a monochromatic source and SAMI reconstructs an image of the Doppler back-scattered (DBS) signal. By assuming that density fluctuations are extended along magnetic field lines, and knowing that the strongest back-scattered signals are directed perpendicular to the density fluctuations, SAMI's 2-D DBS imaging capability can be used to measure the pitch of the edge magnetic field. In this paper, we present preliminary pitch angle measurements obtained by SAMI on the Mega Amp Spherical Tokamak (MAST) at Culham Centre for Fusion Energy and on the National Spherical Torus Experiment Upgrade at Princeton Plasma Physics Laboratory. The results demonstrate encouraging agreement between SAMI and other independent measurements.

Color and Vector Flow Imaging in Parallel Ultrasound With Sub-Nyquist Sampling.

PubMed

Madiena, Craig; Faurie, Julia; Poree, Jonathan; Garcia, Damien; Garcia, Damien; Madiena, Craig; Faurie, Julia; Poree, Jonathan

2018-05-01

RF acquisition with a high-performance multichannel ultrasound system generates massive data sets in short periods of time, especially in "ultrafast" ultrasound when digital receive beamforming is required. Sampling at a rate four times the carrier frequency is the standard procedure since this rule complies with the Nyquist-Shannon sampling theorem and simplifies quadrature sampling. Bandpass sampling (or undersampling) outputs a bandpass signal at a rate lower than the maximal frequency without harmful aliasing. Advantages over Nyquist sampling are reduced storage volumes and data workflow, and simplified digital signal processing tasks. We used RF undersampling in color flow imaging (CFI) and vector flow imaging (VFI) to decrease data volume significantly (factor of 3 to 13 in our configurations). CFI and VFI with Nyquist and sub-Nyquist samplings were compared in vitro and in vivo. The estimate errors due to undersampling were small or marginal, which illustrates that Doppler and vector Doppler images can be correctly computed with a drastically reduced amount of RF samples. Undersampling can be a method of choice in CFI and VFI to avoid information overload and reduce data transfer and storage.

Preliminary measurements of the edge magnetic field pitch from 2-D Doppler backscattering in MAST and NSTX-U (invited).

PubMed

Vann, R G L; Brunner, K J; Ellis, R; Taylor, G; Thomas, D A

2016-11-01

The Synthetic Aperture Microwave Imaging (SAMI) system is a novel diagnostic consisting of an array of 8 independently phased antennas. At any one time, SAMI operates at one of the 16 frequencies in the range 10-34.5 GHz. The imaging beam is steered in software post-shot to create a picture of the entire emission surface. In SAMI's active probing mode of operation, the plasma edge is illuminated with a monochromatic source and SAMI reconstructs an image of the Doppler back-scattered (DBS) signal. By assuming that density fluctuations are extended along magnetic field lines, and knowing that the strongest back-scattered signals are directed perpendicular to the density fluctuations, SAMI's 2-D DBS imaging capability can be used to measure the pitch of the edge magnetic field. In this paper, we present preliminary pitch angle measurements obtained by SAMI on the Mega Amp Spherical Tokamak (MAST) at Culham Centre for Fusion Energy and on the National Spherical Torus Experiment Upgrade at Princeton Plasma Physics Laboratory. The results demonstrate encouraging agreement between SAMI and other independent measurements.

Shear wave speed and dispersion measurements using crawling wave chirps.

PubMed

Hah, Zaegyoo; Partin, Alexander; Parker, Kevin J

2014-10-01

This article demonstrates the measurement of shear wave speed and shear speed dispersion of biomaterials using a chirp signal that launches waves over a range of frequencies. A biomaterial is vibrated by two vibration sources that generate shear waves inside the medium, which is scanned by an ultrasound imaging system. Doppler processing of the acquired signal produces an image of the square of vibration amplitude that shows repetitive constructive and destructive interference patterns called "crawling waves." With a chirp vibration signal, successive Doppler frames are generated from different source frequencies. Collected frames generate a distinctive pattern which is used to calculate the shear speed and shear speed dispersion. A special reciprocal chirp is designed such that the equi-phase lines of a motion slice image are straight lines. Detailed analysis is provided to generate a closed-form solution for calculating the shear wave speed and the dispersion. Also several phantoms and an ex vivo human liver sample are scanned and the estimation results are presented. © The Author(s) 2014.

Airborne Microwave Imaging of River Velocities

NASA Technical Reports Server (NTRS)

Plant, William J.

2002-01-01

The objective of this project was to determine whether airborne microwave remote sensing systems can measure river surface currents with sufficient accuracy to make them prospective instruments with which to monitor river flow from space. The approach was to fly a coherent airborne microwave Doppler radar, developed by APL/UW, on a light airplane along several rivers in western Washington state over an extended period of time. The fundamental quantity obtained by this system to measure river currents is the mean offset of the Doppler spectrum. Since this scatter can be obtained from interferometric synthetic aperture radars (INSARs), which can be flown in space, this project provided a cost effective means for determining the suitability of spaceborne INSAR for measuring river flow.

Low-frequency high-definition power Doppler in visualizing and defining fetal pulmonary venous connections.

PubMed

Liu, Lin; He, Yihua; Li, Zhian; Gu, Xiaoyan; Zhang, Ye; Zhang, Lianzhong

2014-07-01

The use of low-frequency high-definition power Doppler in assessing and defining pulmonary venous connections was investigated. Study A included 260 fetuses at gestational ages ranging from 18 to 36 weeks. Pulmonary veins were assessed by performing two-dimensional B-mode imaging, color Doppler flow imaging (CDFI), and low-frequency high-definition power Doppler. A score of 1 was assigned if one pulmonary vein was visualized, 2 if two pulmonary veins were visualized, 3 if three pulmonary veins were visualized, and 4 if four pulmonary veins were visualized. The detection rate between Exam-1 and Exam-2 (intra-observer variability) and between Exam-1 and Exam-3 (inter-observer variability) was compared. In study B, five cases with abnormal pulmonary venous connection were diagnosed and compared to their anatomical examination. In study A, there was a significant difference between CDFI and low-frequency high-definition power Doppler for the four pulmonary veins observed (P < 0.05). The detection rate of each pulmonary vein when employing low-frequency high-definition power Doppler was higher than that when employing two-dimensional B-mode imaging or CDFI. There was no significant difference between the intra- and inter-observer variabilities using low-frequency high-definition power Doppler display of pulmonary veins (P > 0.05). The coefficient correlation between Exam-1 and Exam-2 was 0.844, and the coefficient correlation between Exam-1 and Exam-3 was 0.821. In study B, one case of total anomalous pulmonary venous return and four cases of partial anomalous pulmonary venous return were diagnosed by low-frequency high-definition power Doppler and confirmed by autopsy. The assessment of pulmonary venous connections by low-frequency high-definition power Doppler is advantageous. Pulmonary venous anatomy can and should be monitored during fetal heart examination.

Development of a system for acquiring, reconstructing, and visualizing three-dimensional ultrasonic angiograms

NASA Astrophysics Data System (ADS)

Edwards, Warren S.; Ritchie, Cameron J.; Kim, Yongmin; Mack, Laurence A.

1995-04-01

We have developed a three-dimensional (3D) imaging system using power Doppler (PD) ultrasound (US). This system can be used for visualizing and analyzing the vascular anatomy of parenchymal organs. To create the 3D PD images, we acquired a series of two-dimensional PD images from a commercial US scanner and recorded the position and orientation of each image using a 3D magnetic position sensor. Three-dimensional volumes were reconstructed using specially designed software and then volume rendered for display. We assessed the feasibility and geometric accuracy of our system with various flow phantoms. The system was then tested on a volunteer by scanning a transplanted kidney. The reconstructed volumes of the flow phantom contained less than 1 mm of geometric distortion and the 3D images of the transplanted kidney depicted the segmental, arcuate, and interlobar vessels.

The development of a combined b-mode, ARFI, and spectral Doppler ultrasound imaging system for investigating cardiovascular stiffness and hemodynamics

NASA Astrophysics Data System (ADS)

Doherty, Joshua R.; Dumont, Douglas M.; Trahey, Gregg E.

2011-03-01

The progression of atherosclerotic disease, caused by the formation of plaques within arteries, is a complex process believed to be a function of the localized mechanical properties and hemodynamic loading associated with the arterial wall. It is hypothesized that measurements of vascular stiffness and wall-shear rate (WSR) may provide important information regarding vascular remodeling, endothelial function, and the growth of soft-lipid filled plaques that could help a clinician better diagnose a patient's risk of clinical events such as stroke. To that end, the approach taken in this work was to combine conventional B-mode, Acoustic Radiation Force Impulse (ARFI), Shear Wave Elasticity Imaging (SWEI), and spectral Doppler techniques into a single imaging system capable of simultaneously measuring the tissue displacements and WSR throughout the cardiac cycle and over several heartbeats. Implemented on a conventional scanner, the carotid arteries of human subjects were scanned to demonstrate the initial in vivo feasibility of the method. Two non-invasive ultrasound based imaging methods, SAD-SWEI and SAD-Gated Imaging, were developed that measure ARF-induced on-axis tissue displacements, off-axis transverse wave velocities, and WSR throughout the cardiac cycle. Human carotid artery scans were performed in vivo on 5 healthy subjects. Statistical differences were observed in both on-axis proximal wall displacements and transverse wave velocities during diastole compared to systole.

Crystal and source characterization for the Crystal Backlighter Imager capability at the National Ignition Facility

NASA Astrophysics Data System (ADS)

Krauland, C. M.; Hall, G. N.; Buscho, J. G.; Hibbard, R.; McCarville, T. J.; Lowe-Webb, R.; Ayers, S. L.; Kalantar, D.; Kohut, T.; Kemp, G. E.; Bradley, D. K.; Bell, P.; Landen, O. L.; Brewster, T. N.; Piston, K.

2017-10-01

The Crystal Backlighter Imager (CBI) is a very narrow bandwidth ( 10 eV) x-ray radiography system that uses Bragg reflection from a spherically-curved crystal at near normal incidence. This diagnostic has the capability to image late in an ICF implosion because it only requires the brightness of the backlighter to be larger than the capsule self-emission in that narrow bandwidth. While the limited bandwidth is advantageous for this reason, it also requires that the effective energy of the backlighter atomic line is known to 1 eV accuracy for proper crystal alignment. Any Doppler shift in the line energy must be understood for the imaging system to work. The work presented details characterization experiments done at the Jupiter Laser Facility with a Si (8 6 2) crystal that will be used with a Selenium backlighter in the NIF CBI diagnostic. We used the spherically-bent crystals to image a small ( 200 µm) He α source generated by the Janus laser on a Se foil. Scanning Bragg angles over multiple shots allowed us to map out the spectral line intensity distribution for optimal alignment in NIF. A subsequent Doppler shift measurement using CBI on NIF will also be presented with complementary HYDRA modeling for both experiments. Prepared by LLNL under Contract DE-AC52-07NA27344 and by General Atomics under Contract DE-NA0001808.

Radar signal analysis of ballistic missile with micro-motion based on time-frequency distribution

NASA Astrophysics Data System (ADS)

Wang, Jianming; Liu, Lihua; Yu, Hua

2015-12-01

The micro-motion of ballistic missile targets induces micro-Doppler modulation on the radar return signal, which is a unique feature for the warhead discrimination during flight. In order to extract the micro-Doppler feature of ballistic missile targets, time-frequency analysis is employed to process the micro-Doppler modulated time-varying radar signal. The images of time-frequency distribution (TFD) reveal the micro-Doppler modulation characteristic very well. However, there are many existing time-frequency analysis methods to generate the time-frequency distribution images, including the short-time Fourier transform (STFT), Wigner distribution (WD) and Cohen class distribution, etc. Under the background of ballistic missile defence, the paper aims at working out an effective time-frequency analysis method for ballistic missile warhead discrimination from the decoys.

Lidar Systems for Precision Navigation and Safe Landing on Planetary Bodies

NASA Technical Reports Server (NTRS)

Amzajerdian, Farzin; Pierrottet, Diego F.; Petway, Larry B.; Hines, Glenn D.; Roback, Vincent E.

2011-01-01

The ability of lidar technology to provide three-dimensional elevation maps of the terrain, high precision distance to the ground, and approach velocity can enable safe landing of robotic and manned vehicles with a high degree of precision. Currently, NASA is developing novel lidar sensors aimed at needs of future planetary landing missions. These lidar sensors are a 3-Dimensional Imaging Flash Lidar, a Doppler Lidar, and a Laser Altimeter. The Flash Lidar is capable of generating elevation maps of the terrain that indicate hazardous features such as rocks, craters, and steep slopes. The elevation maps collected during the approach phase of a landing vehicle, at about 1 km above the ground, can be used to determine the most suitable safe landing site. The Doppler Lidar provides highly accurate ground relative velocity and distance data allowing for precision navigation to the landing site. Our Doppler lidar utilizes three laser beams pointed to different directions to measure line of sight velocities and ranges to the ground from altitudes of over 2 km. Throughout the landing trajectory starting at altitudes of about 20 km, the Laser Altimeter can provide very accurate ground relative altitude measurements that are used to improve the vehicle position knowledge obtained from the vehicle navigation system. At altitudes from approximately 15 km to 10 km, either the Laser Altimeter or the Flash Lidar can be used to generate contour maps of the terrain, identifying known surface features such as craters, to perform Terrain relative Navigation thus further reducing the vehicle s relative position error. This paper describes the operational capabilities of each lidar sensor and provides a status of their development. Keywords: Laser Remote Sensing, Laser Radar, Doppler Lidar, Flash Lidar, 3-D Imaging, Laser Altimeter, Precession Landing, Hazard Detection

Clinical diagnosis by transcutaneous Doppler ultrasound

PubMed Central

Wyse, R. K. H.

1982-01-01

Transcutaneous Doppler ultrasound represents a convenient, reliable technique for the non-invasive diagnosis and assessment of a rapidly increasing number of diverse circulatory disorders. ImagesFig. 2Fig. 3 PMID:7050948

Pulmonary Capillary Hemorrhage Induced by Different Imaging Modes of Diagnostic Ultrasound.

PubMed

Miller, Douglas L; Dong, Zhihong; Dou, Chunyan; Raghavendran, Krishnan

2018-05-01

The induction of pulmonary capillary hemorrhage (PCH) is a well-established non-thermal biological effect of pulsed ultrasound in animal models. Typically, research has been done using laboratory pulsed ultrasound systems with a fixed beam and, recently, by B-mode diagnostic ultrasound. In this study, a GE Vivid 7 Dimension ultrasound machine with 10 L linear array probe was used at 6.6 MHz to explore the relative PCH efficacy of B-mode imaging, M-mode (fixed beam), color angio mode Doppler imaging and pulsed Doppler mode (fixed beam). Anesthetized rats were scanned in a warmed water bath, and thresholds were determined by scanning at different power steps, 2 dB apart, in different groups of six rats. Exposures were performed for 5 min, except for a 15-s M-mode group. Peak rarefactional pressure amplitude thresholds were 1.5 MPa for B-mode and 1.1 MPa for angio Doppler mode. For the non-scanned modes, thresholds were 1.1 MPa for M-mode and 0.6 MPa for pulsed Doppler mode with its relatively high duty cycle (7.7 × 10 -3 vs. 0.27 × 10 -3 for M-mode). Reducing the duration of M-mode to 15 s (from 300 s) did not significantly reduce PCH (area, volume or depth) for some power settings, but the threshold was increased to 1.4 MPa. Pulmonary sonographers should be aware of this unique adverse bio-effect of diagnostic ultrasound and should consider reduced on-screen mechanical index settings for potentially vulnerable patients. Copyright © 2018 World Federation for Ultrasound in Medicine and Biology. Published by Elsevier Inc. All rights reserved.

Detection of cavernous transformation of the portal vein by contrast-enhanced ultrasound.

PubMed

Hwang, Misun; Thimm, Matthew A; Guerrerio, Anthony L

2018-06-01

Cavernous transformation of the portal vein can be missed on color Doppler exam or arterial phase cross-sectional imaging due to their slow flow and delayed enhancement. Contrast-enhanced ultrasound (CEUS) offers many advantages over other imaging techniques and can be used to successfully detect cavernous transformations of the portal vein. A 10-month-old female was followed for repeat episodes of hematemesis. Computed tomography angiography (CTA) and magnetic resonance arteriogram (MRA) and portal venography were performed. Color Doppler exam of the portal vein was performed followed by administration of Lumason, a microbubble US contrast agent. Magnetic resonance arteriogram, CTA, and color Doppler exam at the time of initial presentation was unremarkable without obvious vascular malformation within the limits of motion degraded exam. At 8-month follow-up, esophagogastroduodenoscopy revealed a vascular malformation in the distal esophagus which was sclerosed. At 6 month after sclerosis of the lesion, portal venography revealed occlusion of the portal vein with extensive collateralization. Color Doppler revealed subtle hyperarterialization and periportal collaterals. CEUS following color Doppler exam demonstrated extensive enhancement of periportal collaterals. Repeat color Doppler after contrast administration demonstrated extensive Doppler signal in the collateral vessels, suggestive of cavernous transformation. We describe a case of cavernous transformation of the portal vein missed on initial color Doppler, CTA and MRA, but detected with contrast-enhanced ultrasound technique.

Real time 3D structural and Doppler OCT imaging on graphics processing units

NASA Astrophysics Data System (ADS)

Sylwestrzak, Marcin; Szlag, Daniel; Szkulmowski, Maciej; Gorczyńska, Iwona; Bukowska, Danuta; Wojtkowski, Maciej; Targowski, Piotr

2013-03-01

In this report the application of graphics processing unit (GPU) programming for real-time 3D Fourier domain Optical Coherence Tomography (FdOCT) imaging with implementation of Doppler algorithms for visualization of the flows in capillary vessels is presented. Generally, the time of the data processing of the FdOCT data on the main processor of the computer (CPU) constitute a main limitation for real-time imaging. Employing additional algorithms, such as Doppler OCT analysis, makes this processing even more time consuming. Lately developed GPUs, which offers a very high computational power, give a solution to this problem. Taking advantages of them for massively parallel data processing, allow for real-time imaging in FdOCT. The presented software for structural and Doppler OCT allow for the whole processing with visualization of 2D data consisting of 2000 A-scans generated from 2048 pixels spectra with frame rate about 120 fps. The 3D imaging in the same mode of the volume data build of 220 × 100 A-scans is performed at a rate of about 8 frames per second. In this paper a software architecture, organization of the threads and optimization applied is shown. For illustration the screen shots recorded during real time imaging of the phantom (homogeneous water solution of Intralipid in glass capillary) and the human eye in-vivo is presented.

Evaluation of contrast-enhanced power Doppler imaging for measuring blood flow

NASA Astrophysics Data System (ADS)

Ansaloni, Sara; Arger, Peter H.; Cary, Ted W.; Sehgal, Chandra M.

2005-04-01

Power Doppler ultrasound enhanced by microbubble contrast agent has been used to image tissue vascularity and blood flow for the assessment of antivascular therapies. We have proposed a multigating technique that measures bubble concentration as a function of ultrasound exposure for deriving tumor blood flow and vascularity.1 Techniques using ultrasound contrast agent are known to be sensitive to the choice of imaging parameters like mechanical index and tissue attenuation. In this paper, the roles of mechanical index (MI) and tissue attenuation were evaluated experimentally in a rubber tubing flow phantom connected to a mixing chamber and a variable speed pump. The contrast was injected in the mixing chamber and the flow rate was measured using power Doppler imaging. The measurements were repeated at different MIs (0.1 to 1.3), and at different levels of attenuation, obtained with solutions of glycerol-water (10-20%). True flow was measured by collecting liquid flowing out of the phantom over a fixed duration. At low MI (<0.5), the grayscale and Doppler signal were weak, making these images unsuitable for analysis. At higher MI (> 0.8), there was a well-defined enhancement by contrast agent resulting in reproducible flow measurements at variable MIs. A balance between the number of bubbles destroyed and the echo they generate must be achieved for optimal imaging. The increased attenuation of ultrasound by the overlying medium did not influence the flow measurements.

Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system.

PubMed

Reif, Roberto; Qin, Jia; Shi, Lei; Dziennis, Suzan; Zhi, Zhongwei; Nuttall, Alfred L; Wang, Ruikang K

2012-01-01

A synchronized dual-wavelength laser speckle contrast imaging (DWLSCI) system and a Doppler optical microangiography (DOMAG) system was developed to determine several ischemic parameters in the cochlea due to a systemic hypoxic challenge. DWLSCI can obtain two-dimensional data, and was used to determine the relative changes in cochlear blood flow, and change in the concentrations of oxyhemoglobin (HbO), deoxyhemoglobin (Hb) and total hemoglobin (HbT) in mice. DOMAG can obtain three-dimensional data, and was used to determine the changes in cochlear blood flow with single vessel resolution. It was demonstrated that during a hypoxic challenge there was an increase in the concentrations of Hb, a decrease in the concentrations of HbO and cochlear blood flow, and a slight decrease in the concentration of HbT. Also, the rate of change in the concentrations of Hb and HbO was quantified during and after the hypoxic challenge. The ability to simultaneously measure these ischemic parameters with high spatio-temporal resolution will allow the detailed quantitative analysis of several hearing disorders, and will be useful for diagnosing and developing treatments.

New Approaches For Asteroid Spin State and Shape Modeling From Delay-Doppler Radar Images

NASA Astrophysics Data System (ADS)

Raissi, Chedy; Lamee, Mehdi; Mosiane, Olorato; Vassallo, Corinne; Busch, Michael W.; Greenberg, Adam; Benner, Lance A. M.; Naidu, Shantanu P.; Duong, Nicholas

2016-10-01

Delay-Doppler radar imaging is a powerful technique to characterize the trajectories, shapes, and spin states of near-Earth asteroids; and has yielded detailed models of dozens of objects. Reconstructing objects' shapes and spins from delay-Doppler data is a computationally intensive inversion problem. Since the 1990s, delay-Doppler data has been analyzed using the SHAPE software. SHAPE performs sequential single-parameter fitting, and requires considerable computer runtime and human intervention (Hudson 1993, Magri et al. 2007). Recently, multiple-parameter fitting algorithms have been shown to more efficiently invert delay-Doppler datasets (Greenberg & Margot 2015) - decreasing runtime while improving accuracy. However, extensive human oversight of the shape modeling process is still required. We have explored two new techniques to better automate delay-Doppler shape modeling: Bayesian optimization and a machine-learning neural network.One of the most time-intensive steps of the shape modeling process is to perform a grid search to constrain the target's spin state. We have implemented a Bayesian optimization routine that uses SHAPE to autonomously search the space of spin-state parameters. To test the efficacy of this technique, we compared it to results with human-guided SHAPE for asteroids 1992 UY4, 2000 RS11, and 2008 EV5. Bayesian optimization yielded similar spin state constraints within a factor of 3 less computer runtime.The shape modeling process could be further accelerated using a deep neural network to replace iterative fitting. We have implemented a neural network with a variational autoencoder (VAE), using a subset of known asteroid shapes and a large set of synthetic radar images as inputs to train the network. Conditioning the VAE in this manner allows the user to give the network a set of radar images and get a 3D shape model as an output. Additional development will be required to train a network to reliably render shapes from delay-Doppler images.This work was supported by NASA Ames, NVIDIA, Autodesk and the SETI Institute as part of the NASA Frontier Development Lab program.

Synthetic Aperture Microwave Imaging (SAMI) of the plasma edge on NSTX-U

NASA Astrophysics Data System (ADS)

Vann, Roddy; Taylor, Gary; Brunner, Jakob; Ellis, Bob; Thomas, David

2016-10-01

The Synthetic Aperture Microwave Imaging (SAMI) system is a unique phased-array microwave camera with a +/-40° field of view in both directions. It can image cut-off surfaces corresponding to frequencies in the range 10-34.5GHz; these surfaces are typically in the plasma edge. SAMI operates in two modes: either imaging thermal emission from the plasma (often modified by its interaction with the plasma edge e.g. via BXO mode conversion) or ``active probing'' i.e. injecting a broad beam at the plasma surface and imaging the reflected/back-scattered signal. SAMI was successfully pioneered on the Mega-Amp Spherical Tokamak (MAST) at Culham Centre for Fusion Energy. SAMI has now been installed and commissioned on the National Spherical Torus Experiment Upgrade (NSTX-U) at Princeton Plasma Physics Laboratory. The firmware has been upgraded to include real-time digital filtering, which enables continuous acquisition of the Doppler back-scattered active probing data. In this poster we shall present SAMI's analysis of the plasma edge on NSTX-U including measurements of the edge pitch angle on NSTX-U using SAMI's unique 2-D Doppler-backscattering capability.

Analysing Simple Motions Using the Doppler Effect--"Seeing" Sound

ERIC Educational Resources Information Center

Stonawski, Tamás; Gálik, Tamás

2017-01-01

The Doppler effect has seen widespread use in the past hundred years. It is used for medical imaging, for measuring speed, temperature, direction, etc, and it makes the spatial relations of motion easy to map. The Doppler effect also allows GPS receivers to measure the speed of a vehicle significantly more accurately than dashboard speedometers.…

Photonic Doppler velocimetry lens array probe incorporating stereo imaging

DOEpatents

Malone, Robert M.; Kaufman, Morris I.

2015-09-01

A probe including a multiple lens array is disclosed to measure velocity distribution of a moving surface along many lines of sight. Laser light, directed to the moving surface is reflected back from the surface and is Doppler shifted, collected into the array, and then directed to detection equipment through optic fibers. The received light is mixed with reference laser light and using photonic Doppler velocimetry, a continuous time record of the surface movement is obtained. An array of single-mode optical fibers provides an optic signal to the multiple lens array. Numerous fibers in a fiber array project numerous rays to establish many measurement points at numerous different locations. One or more lens groups may be replaced with imaging lenses so a stereo image of the moving surface can be recorded. Imaging a portion of the surface during initial travel can determine whether the surface is breaking up.

Development of the NASA High-Altitude Imaging Wind and Rain Airborne Profiler

NASA Technical Reports Server (NTRS)

Li, Lihua; Heymsfield, Gerald; Carswell, James; Schaubert, Dan; McLinden, Matthew; Vega, Manuel; Perrine, Martin

2011-01-01

The scope of this paper is the development and recent field deployments of the High-Altitude Imaging Wind and Rain Airborne Profiler (HIWRAP), which was funded under the NASA Instrument Incubator Program (IIP) [1]. HIWRAP is a dual-frequency (Ka- and Ku-band), dual-beam (300 and 400 incidence angles), conical scanning, Doppler radar system designed for operation on the NASA high-altitude (65,000 ft) Global Hawk Unmanned Aerial System (UAS). It utilizes solid state transmitters along with a novel pulse compression scheme that results in a system with compact size, light weight, less power consumption, and low cost compared to radars currently in use for precipitation and Doppler wind measurements. By combining measurements at Ku- and Ka-band, HIWRAP is able to image winds through measuring volume backscattering from clouds and precipitation. In addition, HIWRAP is also capable of measuring surface winds in an approach similar to SeaWinds on QuikScat. To this end, HIWRAP hardware and software development has been completed. It was installed on the NASA WB57 for instrument test flights in March, 2010 and then deployed on the NASA Global Hawk for supporting the Genesis and Rapid Intensification Processes (GRIP) field campaign in August-September, 2010. This paper describes the scientific motivations of the development of HIWRAP as well as system hardware, aircraft integration and flight missions. Preliminary data from GRIP science flights is also presented.

Localization of needle tip with color doppler during pericardiocentesis: In vitro validation and initial clinical application

NASA Technical Reports Server (NTRS)

Armstrong, G.; Cardon, L.; Vilkomerson, D.; Lipson, D.; Wong, J.; Rodriguez, L. L.; Thomas, J. D.; Griffin, B. P.

2001-01-01

This study evaluates a new device that uses color Doppler ultrasonography to enable real-time image guidance of the aspirating needle, which has not been possible until now. The ColorMark device (EchoCath Inc, Princeton, NJ) induces high-frequency, low-amplitude vibrations in the needle to enable localization with color Doppler. We studied this technique in 25 consecutive patients undergoing pericardiocentesis, and in vitro, in a urethane phantom with which the accuracy of color Doppler localization of the needle tip was compared with that obtained by direct measurement. Tip localization was excellent in vitro; errors axial to the ultrasound beam (velocity Doppler -0.13 +/- 0.90 mm, power Doppler -0.05 +/- 1.7 mm) were less than lateral errors (velocity -0.36 +/- 1.8 mm, power -0.02 +/- 2.8 mm). In 18 of 25 patients, the needle was identified and guided into the pericardial space with the ColorMark technique, and it allowed successful, uncomplicated drainage of fluid. Initial failures were the result of incorrect settings on the echocardiographic machine and inappropriate combinations of the needle puncture site and imaging window. This study demonstrates a novel color Doppler technique that is highly accurate at localizing a needle tip. The technique is feasible for guiding pericardiocentesis. Further clinical validation of this technique is required.

Neovascularity in patellar tendinopathy and the response to eccentric training: a case report using Power Doppler ultrasound.

PubMed

McCreesh, Karen M; Riley, Sara J; Crotty, James M

2013-12-01

This report describes the case of an amateur soccer player with chronic patellar tendinopathy who underwent ultrasound imaging before and after engaging in an 8-week programme of eccentric exercise. On initial assessment, greyscale ultrasound imaging demonstrated tendon thickening and reduced echogenicity, while Power Doppler imaging demonstrated a large amount of neovascularity. After 8 weeks of an eccentric loading programme, the patient reported significantly improved symptoms and functional scores, while follow-up imaging demonstrated improvement in the echo appearance of the tendon and complete resolution of the neovascularity. The association between neovascularity and symptoms in tendinopathy research is conflicting, with a paucity of research in the area of patellar tendinopathy. While further research is needed to clarify the significance of greyscale and Power Doppler ultrasound changes in relation to symptoms in patellar tendinopathy, ultrasound imaging was shown to be a useful adjunct to diagnosis and outcome assessment in this case. Copyright © 2012 Elsevier Ltd. All rights reserved.

Apparatus and method using a holographic optical element for converting a spectral distribution to image points

NASA Technical Reports Server (NTRS)

McGill, Matthew J. (Inventor); Scott, Vibart S. (Inventor); Marzouk, Marzouk (Inventor)

2001-01-01

A holographic optical element transforms a spectral distribution of light to image points. The element comprises areas, each of which acts as a separate lens to image the light incident in its area to an image point. Each area contains the recorded hologram of a point source object. The image points can be made to lie in a line in the same focal plane so as to align with a linear array detector. A version of the element has been developed that has concentric equal areas to match the circular fringe pattern of a Fabry-Perot interferometer. The element has high transmission efficiency, and when coupled with high quantum efficiency solid state detectors, provides an efficient photon-collecting detection system. The element may be used as part of the detection system in a direct detection Doppler lidar system or multiple field of view lidar system.

Dual Channel S-Band Frequency Modulated Continuous Wave Through-Wall Radar Imaging

PubMed Central

Oh, Daegun; Kim, Sunwoo; Chong, Jong-Wha

2018-01-01

This article deals with the development of a dual channel S-Band frequency-modulated continuous wave (FMCW) system for a through-the-wall imaging (TWRI) system. Most existing TWRI systems using FMCW were developed for synthetic aperture radar (SAR) which has many drawbacks such as the need for several antenna elements and movement of the system. Our implemented TWRI system comprises a transmitting antenna and two receiving antennas, resulting in a significant reduction of the number of antenna elements. Moreover, a proposed algorithm for range-angle-Doppler 3D estimation based on a 3D shift invariant structure is utilized in our implemented dual channel S-band FMCW TWRI system. Indoor and outdoor experiments were conducted to image the scene beyond a wall for water targets and person targets, respectively. The experimental results demonstrate that high-quality imaging can be achieved under both experimental scenarios. PMID:29361777

High-speed optical coherence tomography using fiberoptic acousto-optic phase modulation

NASA Astrophysics Data System (ADS)

Xie, Tuqiang; Wang, Zhenguo; Pan, Yingtian

2003-12-01

We report a new rapid-scanning optical delay device suitable for high-speed optical coherence tomography (OCT) in which an acousto-optic modulator (AOM) is used to independently modulate the Doppler frequency shift of the reference light beam for optical heterodyne detection. Experimental results show that the fluctuation of the measured Doppler frequency shift is less than +/-0.2% over 95% duty cycle of OCT imaging, thus allowing for enhanced signal-to-noise ratio of optical heterodyne detection. The increased Doppler frequency shift by AOM also permits complete envelop demodulation without the compromise of reducing axial resolution; if used with a resonant rapid-scanning optical delay, it will permit high-performance real-time OCT imaging. Potentially, this new rapid-scanning optical delay device will improve the performance of high-speed Doppler OCT techniques.

Combined use of Doppler OCT and en face OCT functions for discrimination of an aneurysm in the lamina cribrosa from a disc hemorrhage.

PubMed

Holló, Gábor

2015-12-01

In addition to retinal nerve fiber layer thickness measurements, the recently introduced AngioVue optical coherence tomography (OCT) offers corresponding layer-by-layer Doppler OCT and en face OCT functions, for simultaneous evaluation of perfusion and structure of the optic nerve head. We investigated the clinical usefulness of combined use of Doppler and en face Fourier-domain OCT functions of the AngioVue Fourier-domain OCT for discrimination of a disc hemorrhage and a disc hemorrhage-like atypical vessel structure located deep in the lamina cribrosa. We present our findings with AngioVue OCT on a disc hemorrhage and a spatially related retinal nerve fiber layer bundle defect in a glaucomatous eye (case 1). Both alterations were detected on en face OCT images without any Doppler OCT signal. We also report on an aneurysm suggestive for a disc hemorrhage on clinical examination and disc photography in a treated ocular hypertensive eye (case 2). The aneurysm was within the lamina cribrosa tissue at the border of the cup and the neuroretinal rim. This vascular structure produced strong Doppler signals but no structurally detectable signs on the en face OCT images. Combined evaluation of corresponding Doppler OCT and en face OCT images enables ophthalmologists to easily separate true disc hemorrhages from disc hemorrhage-like deep vascular structures. This is of clinical significance in preventing unnecessary intensification of pressure-lowering treatment in glaucoma.

Absolute wavelength calibration of a Doppler spectrometer with a custom Fabry-Perot optical system

NASA Astrophysics Data System (ADS)

Baltzer, M. M.; Craig, D.; Den Hartog, D. J.; Nishizawa, T.; Nornberg, M. D.

2016-11-01

An Ion Doppler Spectrometer (IDS) is used for fast measurements of C VI line emission (343.4 nm) in the Madison Symmetric Torus. Absolutely calibrated flow measurements are difficult because the IDS records data within 0.25 nm of the line. Commercial calibration lamps do not produce lines in this narrow range. A light source using an ultraviolet LED and etalon was designed to provide a fiducial marker 0.08 nm wide. The light is coupled into the IDS at f/4, and a holographic diffuser increases homogeneity of the final image. Random and systematic errors in data analysis were assessed. The calibration is accurate to 0.003 nm, allowing for flow measurements accurate to 3 km/s. This calibration is superior to the previous method which used a time-averaged measurement along a chord believed to have zero net Doppler shift.

Absolute wavelength calibration of a Doppler spectrometer with a custom Fabry-Perot optical system.

PubMed

Baltzer, M M; Craig, D; Den Hartog, D J; Nishizawa, T; Nornberg, M D

2016-11-01

An Ion Doppler Spectrometer (IDS) is used for fast measurements of C VI line emission (343.4 nm) in the Madison Symmetric Torus. Absolutely calibrated flow measurements are difficult because the IDS records data within 0.25 nm of the line. Commercial calibration lamps do not produce lines in this narrow range. A light source using an ultraviolet LED and etalon was designed to provide a fiducial marker 0.08 nm wide. The light is coupled into the IDS at f/4, and a holographic diffuser increases homogeneity of the final image. Random and systematic errors in data analysis were assessed. The calibration is accurate to 0.003 nm, allowing for flow measurements accurate to 3 km/s. This calibration is superior to the previous method which used a time-averaged measurement along a chord believed to have zero net Doppler shift.

The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments

NASA Astrophysics Data System (ADS)

de Jong, Daan L. K.; Meel-van den Abeelen, Aisha S. S.; Lagro, Joep; Claassen, Jurgen A. H. R.; Slump, Cornelis H.

2014-03-01

The measurement of the blood flow in the middle cerebral artery (MCA) using transcranial Doppler ultrasound (US) imaging is clinically relevant for the study of cerebral autoregulation. Especially in the aging population, impairement of the autoregulation may coincide or relate to loss of perfusion and consequently loss of brain function. The cerebral autoregulation can be assessed by relating the blood pressure to the blood flow in the brain. Doppler US is a widely used, non-invasive method to measure the blood flow in the MCA. However, Doppler flow imaging is known to produce results that are dependent of the operator. The angle of the probe insonation with respect to the centerline of the blood vessel is a well known factor for output variability. In patients also the skull must be traversed and the MCA must be detected, influencing the US signal intensity. In this contribution we report two studies. We describe first an in-vitro setup to study the Doppler flow in a situation where the ground truth is known. Secondly, we report on a study with healthy volunteers where the effects of small probe displacements on the flow velocity signals are investigated. For the latter purpose, a special probe holder was designed to control the experiment.

Intrahepatic portosystemic venous shunt: diagnosis by color Doppler imaging.

PubMed

Kudo, M; Tomita, S; Tochio, H; Minowa, K; Todo, A

1993-05-01

Intrahepatic portosystemic venous shunt is a rare clinical entity; only 33 such cases have been reported. It may be congenital, or secondary to portal hypertension. Five patients with this disorder are presented, each of whom was diagnosed by color Doppler imaging, including waveform spectral analysis. One patient with clinical evidence of cirrhosis and portal hypertension had episodes of hepatic encephalopathy and elevated blood levels of ammonia. This patient had a large tubular shunt between the posterior branch of the portal vein and the inferior vena cava. Shunts of this type are considered to be collateral pathways which develop in the hepatic parenchyma as a result of portal hypertension. The other four patients had no evidence of liver disease, and all four evidenced an aneurysmal portohepatic venous shunt within the liver parenchyma. Shunts of this type are considered congenital. The diagnosis of intrahepatic portosystemic venous shunts was established by color Doppler imaging, which demonstrated a direct communication of color flow signals between the portal vein and hepatic vein, in addition to the characterization of the Doppler spectrum at each sampling point from a continuous waveform signal (portal vein) to a turbulent signal (aneurysmal cavity), and finally, to a biphasic waveform signal (hepatic vein). As demonstrated by the five patients, color Doppler imaging is useful in the diagnosis of an intrahepatic portosystemic hepatic venous shunt, and the measurement of shunt ratio may be useful in the follow-up and determining the therapeutic option.

Linear prediction data extrapolation superresolution radar imaging

NASA Astrophysics Data System (ADS)

Zhu, Zhaoda; Ye, Zhenru; Wu, Xiaoqing

1993-05-01

Range resolution and cross-range resolution of range-doppler imaging radars are related to the effective bandwidth of transmitted signal and the angle through which the object rotates relatively to the radar line of sight (RLOS) during the coherent processing time, respectively. In this paper, linear prediction data extrapolation discrete Fourier transform (LPDEDFT) superresolution imaging method is investigated for the purpose of surpassing the limitation imposed by the conventional FFT range-doppler processing and improving the resolution capability of range-doppler imaging radar. The LPDEDFT superresolution imaging method, which is conceptually simple, consists of extrapolating observed data beyond the observation windows by means of linear prediction, and then performing the conventional IDFT of the extrapolated data. The live data of a metalized scale model B-52 aircraft mounted on a rotating platform in a microwave anechoic chamber and a flying Boeing-727 aircraft were processed. It is concluded that, compared to the conventional Fourier method, either higher resolution for the same effective bandwidth of transmitted signals and total rotation angle of the object or equal-quality images from smaller bandwidth and total angle may be obtained by LPDEDFT.

Three-dimensional power Doppler sonography in screening for carotid artery disease.

PubMed

Keberle, M; Jenett, M; Beissert, M; Jahns, R; Haerten, R; Hahn, D

2000-01-01

Color Doppler sonography has gained considerable recognition as a noninvasive method to detect carotid artery disease and to assess the degree of carotid artery stenosis. However, results are highly operator-dependent and cannot be presented as survey images. The purpose of this study was to evaluate real-time 3-dimensional (3D) power Doppler sonography as a method for screening for atherosclerosis in the carotid arteries. We prospectively screened 75 patients for carotid artery disease using both conventional color Doppler sonography and 3D power Doppler sonography, and the results from the 2 modalities were compared. A total of 150 common carotid arteries, 150 internal carotid arteries, and 150 external carotid arteries were examined utilizing a 7.5-MHz linear-array transducer combined with tissue harmonic imaging. Color Doppler sonography detected 297 normal or atherosclerotic arteries without stenosis, 57 arteries with mild (1-49%) stenosis, 41 with moderate (50-69%) stenosis, 32 with severe (70-99%) stenosis, and 9 with occlusions. The degree of stenosis determined by color Doppler sonography correlated with that determined by 3D power Doppler sonography (r = 0.982-0.998). Moreover, there was a good correlation between the measurements for both the length of the lesion and its distance from the bulb as determined by the 3D volume surveys and by color Doppler sonography (r = 0.986). The interobserver variability rate was 3.7% +/- 0.5%. Generally, the acquisition and reconstruction of the 3D data took less than 5 minutes. 3D power Doppler sonography is easy to perform and is an accurate method in screening for atherosclerotic lesions of the carotid arteries. Moreover, it provides excellent 3D volume surveys that may be helpful in the planning of surgical treatment. Copyright 2000 John Wiley & Sons, Inc.

Ocular perfusion pressure and color Doppler imaging of the external ophthalmic artery of rabbits treated with sildenafil citrate.

PubMed

Costa, Ana Paula Araujo; Lima, Aline Maria Vasconcelos; da Silva, Luiz Henrique; de Oliveira Alves Carvalho, Rosângela; do Amaral, Andréia Vitor Couto; Borges, Naida Cristina

2016-07-22

It has been proposed that sildenafil citrate can increase ocular blood flow, and that this property can be used to treat ocular disorders that involve reflex vasoconstriction. This study therefore proposes to ascertain the vasodilator effect of the drug on retrobulbar circulation in healthy rabbits. For this matter rabbits treated with sildenafil citrate or saline solution had their intraocular pressure (IOP), mean arterial pressure (MAP), ocular perfusion pressure (OPP) and color Doppler imaging of the external ophthalmic artery measured prior to treatment and on days one (moment M1), seven (when M2), fourteen (moment M3), twenty-one (moment M4), and thirty (moment M5) of treatment. The MAP and OPP values of treated group were lower than those of control group at all times, and the mean values differed statistically at moments M1 (S = 71.52 mmHg, C = 84.76 mmHg, p = 0.0356) and M5 (S = 71.38 mmHg, C = 85.52 mmHg, p = 0.0252). The IOP and color Doppler values of the external ophthalmic artery did not differ between tested groups. The dose of 10 mg of sildenafil citrate administered to healthy rabbits causes systemic vasodilation and consequently lower values of MAP and OPP. However, it does not induce changes in IOP and retrobulbar hemodynamics identifiable by color Doppler assessment of the external ophthalmic artery.

A unique case of "double-orifice aortic valve"-comprehensive assessment by 2-, 3-dimensional, and color Doppler echocardiography.

PubMed

Stirrup, James E; Cowburn, Peter J; Pousios, Dimitrios; Ohri, Sunil K; Shah, Benoy N

2016-09-01

Transesophageal echocardiography (TEE) is a powerful imaging tool for the comprehensive assessment of valvular structure and function. TEE may be of added benefit when anatomy is difficult to delineate accurately by transthoracic echocardiography. In this article, we present 2-, 3-dimensional, and color Doppler TEE images from a male patient with aortic stenosis. A highly unusual and complex pattern of valvular calcification created a functionally "double-orifice" valve. Such an abnormality may have implications for the accuracy of continuous-wave Doppler echocardiography, which assumes a single orifice valve in native aortic valves. © 2016, Wiley Periodicals, Inc.

A study on the measurement of radar cross section of flighting model based on the range-Doppler imaging

NASA Astrophysics Data System (ADS)

Hashimoto, Osamu; Mizokami, Osamu

The method for measuring radar cross section (RCS) based on Range-Doppler Imaging is discussed. In this method, the measured targets are rotated and the Doppler frequencies caused by each scattering element along the targets are analyzed by FFT. Using this method, each scattered power peak along the flying model is measured. It is found that each part of the RCS of a flying model can be measured and its RCS of a main wing (about 46 dB/sq cm) is greater than of its body (about 20-30 dB/sq cm).

Power Doppler ultrasonography and synovitis: correlating ultrasound imaging with histopathological findings and evaluating the performance of ultrasound equipments.

PubMed

Koski, J M; Saarakkala, S; Helle, M; Hakulinen, U; Heikkinen, J O; Hermunen, H

2006-12-01

To examine the validity of power Doppler ultrasound imaging to identify synovitis, using histopathology as gold standard, and to assess the performance of ultrasound equipments. 44 synovial sites in small and large joints, bursae and tendon sheaths were depicted with ultrasound. A synovial biopsy was performed on the site depicted and a synovial sample was taken for histopathological evaluation. The performance of three ultrasound devices was tested using flow phantoms. A positive Doppler signal was detected in 29 of 35 (83%) of the patients with active histological inflammation. In eight additional samples, histological examination showed other pathological synovial findings and a Doppler signal was detected in five of them. No significant correlation was found between the amount of Doppler signal and histological synovitis score (r = 0.239, p = NS). The amount of subsynovial infiltration of polymorphonuclear leucocytes and surface fibrin correlated significantly with the amount of power Doppler signal: r = 0.397 (p<0.01) and 0.328 (p<0.05), respectively. The ultrasound devices differed in showing the smallest detectable flow. A negative Doppler signal does not exclude the possibility of synovitis. A positive Doppler signal in the synovium is an indicator of an active synovial inflammation in patients. A Doppler signal does not correlate with the extent of the inflammation and it can also be seen in other synovial reactions. It is important that the quality measurements of ultrasound devices are reported, because the results should be evaluated against the quality of the device used.

V405 ANDROMEDA REVISITED

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ribeiro, T.; Baptista, R.; Kafka, S.

We present a multi-epoch time-resolved high-resolution optical spectroscopy study of the short-period (P{sub orb} = 11.2 hr) eclipsing M0V+M5V RS CVn binary V405 Andromeda. By means of indirect imaging techniques, namely Doppler imaging, we study the surface activity features of the M0V component of the system. A modified version of a Doppler imaging code, which takes into account the tidal distortion of the surface of the star, is applied to the multi-epoch data set in order to provide indirect images of the stellar surface. The multi-epoch surface brightness distributions show a low intensity 'belt' of spots at latitudes {+-}40{sup 0}more » and a noticeable absence of high latitude features or polar spots on the primary star of V405 Andromeda. They also reveal slow evolution of the spot distribution over {approx}4 yr. An entropy landscape procedure is used in order to find the set of binary parameters that lead to the smoothest surface brightness distributions. As a result, we find M{sub 1} = 0.51 {+-} 0.03 M{sub sun}, M{sub 2} = 0.21 {+-} 0.01 M{sub sun}, R{sub 1} = 0.71 {+-} 0.01 R{sub sun}, and an inclination i = 65{sup 0} {+-} 1{sup 0}. The resulting systemic velocity is distinct for different epochs, raising the possibility of the existence of a third body in the system.« less

Software for a GPS-Reflection Remote-Sensing System

NASA Technical Reports Server (NTRS)

Lowe, Stephen

2003-01-01

A special-purpose software Global Positioning System (GPS) receiver designed for remote sensing with reflected GPS signals is described in Delay/Doppler-Mapping GPS-Reflection Remote-Sensing System (NPO-30385), which appears elsewhere in this issue of NASA Tech Briefs. The input accepted by this program comprises raw (open-loop) digitized GPS signals sampled at a rate of about 20 MHz. The program processes the data samples to perform the following functions: detection of signals; tracking of phases and delays; mapping of delay, Doppler, and delay/Doppler waveforms; dual-frequency processing; coherent integrations as short as 125 s; decoding of navigation messages; and precise time tagging of observable quantities. The software can perform these functions on all detectable satellite signals without dead time. Open-loop data collected over water, land, or ice and processed by this software can be further processed to extract geophysical information. Possible examples include mean sea height, wind speed and direction, and significant wave height (for observations over the ocean); bistatic-radar terrain images and measures of soil moisture and biomass (for observations over land); and estimates of ice age, thickness, and surface density (for observations over ice).

Detecting Subclinical Biventricular Impairment in Scleroderma Patients by Use of Pulsed-Wave Tissue Doppler Imaging

PubMed Central

Can, Ilknur; Onat, Ahmet Mesut; Aytemir, Kudret; Akdogan, Ali; Ureten, Kemal; Kiraz, Sedat; Ertenli, Ihsan; Tokgozoglu, Lale; Oto, Ali

2009-01-01

Systemic scleroderma is a disease that is characterized by excessive fibroblastic activity and collagen deposition in various organs, including the heart. We sought to evaluate the limits of biventricular function as derived noninvasively from pulsed-wave tissue Doppler imaging (TDI) of tricuspid and mitral annular motion in patients who had scleroderma. We enrolled 24 patients with scleroderma (study group; mean age, 49 ± 11 yr; 20 women) and 24 healthy participants (control group; mean age, 51 ± 9 yr; 19 women). Persons with cardiovascular risk factors were excluded. We obtained images by conventional echocardiography and by pulsed-wave TDI, measuring the respective peak systolic velocities (S, Sm) and peak early (E, Em) and late (A, Am) diastolic velocities. Mean Sm, mean Em, and mean Am were averages of the 4 measured sites (anterior, inferior, lateral, and septal). We calculated noninvasive estimates of left ventricular (LV) filling pressure by dividing E velocities (from the mitral inflow) by Em velocities (E/Em ratios). Biventricular regional Sm, regional LV myocardial Em, and ratios of myocardial Em/atrial component velocity (Em/Am) for the LV, and mean Sm, mean Em, and mean Em/mean Am ratios for the LV were significantly lower in the study group. The E/Em ratio was higher in the study group (7.3 ± 2.6 vs 5.2 ± 1.0, P = 0.01). Global LV systolic and diastolic function did not differ between the groups. Tissue Doppler imaging complements conventional echocardiography in detecting subclinical biventricular impairment in patients with scleroderma who have normal global measurements. PMID:19436783

Hyperemia in plantar fasciitis determined by power Doppler ultrasound.

PubMed

McMillan, Andrew M; Landorf, Karl B; Gregg, Julie M; De Luca, Jason; Cotchett, Matthew P; Menz, Hylton B

2013-12-01

Cross-sectional observational study. To investigate the presence of soft tissue hyperemia in plantar fasciitis with power Doppler ultrasound. Localized hyperemia is an established feature of tendinopathy, suggesting that neurovascular in-growth may contribute to tendon-associated pain in some patients. The presence of abnormal soft tissue vascularity can be assessed with Doppler ultrasound, and a positive finding can assist with targeted treatment plans. However, very little is known regarding the presence of hyperemia in plantar fasciitis and the ability of routine Doppler ultrasound to identify vascular in-growth in the plantar fascia near its proximal insertion. This observational study included 30 participants with plantar fasciitis unrelated to systemic disease and 30 age- and sex-matched controls. Ultrasound examination was performed with a 13- to 5-MHz linear transducer, and power Doppler images were assessed by 2 blinded investigators. Hyperemia of the plantar fascia was present in 8 of 30 participants with plantar fasciitis and in 2 of 30 controls. The between-group difference for hyperemia, using a 4-point scale, was statistically significant, with participants with plantar fasciitis showing increased Doppler ultrasound signal compared to controls (Mann-Whitney U, P = .03). However, the majority of participants with plantar fasciitis with evidence of hyperemia demonstrated very mild color changes, and only 3 were found to have moderate or marked hyperemia. Mild hyperemia can occur with plantar fasciitis, but most individuals will not exhibit greater soft tissue vascularity when assessed with routine Doppler ultrasound. Clinicians treating plantar fasciitis should not consider a positive Doppler signal as essential for diagnosis of the condition but, rather, as a feature that may help to refine the treatment plan for an individual patient.

Measurement of ciliary beat frequency using Doppler optical coherence tomography.

PubMed

Lemieux, Bryan T; Chen, Jason J; Jing, Joseph; Chen, Zhongping; Wong, Brian J F

2015-11-01

Measuring ciliary beat frequency (CBF) is a technical challenge and difficult to perform in vivo. Doppler optical coherence tomography (D-OCT) is a mesoscopic noncontact imaging modality that provides high-resolution tomographic images and detects micromotion simultaneously in living tissues. In this work we used D-OCT to measure CBF in ex vivo tissue as the first step toward translating this technology to clinical use. Fresh ex vivo samples of rabbit tracheal mucosa were imaged using both D-OCT and phase-contrast microscopy (n = 5). The D-OCT system was designed and built to specification in our lab (1310-nm swept source vertical-cavity surface-emitting laser [VCSEL], 6-μm axial resolution). The samples were placed in culture and incubated at 37°C. A fast Fourier transform was performed on the D-OCT signal recorded on the surface of the samples to gauge CBF. High-speed digital video of the epithelium recorded via phase-contrast microscopy was analyzed to confirm the CBF measurements. The D-OCT system detected Doppler signal at the epithelial layer of ex vivo rabbit tracheal samples suggestive of ciliary motion. CBF was measured at 9.36 ± 1.22 Hz using D-OCT and 9.08 ± 0.48 Hz using phase-contrast microscopy. No significant differences were found between the 2 methods (p > 0.05). D-OCT allows for the quantitative measurement of CBF without the need to resolve individual cilia. Furthermore, D-OCT technology can be incorporated into endoscopic platforms that allow clinicians to readily measure CBF in the office and provide a direct measurement of mucosal health. © 2015 ARS-AAOA, LLC.

Oscillations in the wake of a flare blast wave

NASA Astrophysics Data System (ADS)

Tothova, D.; Innes, D. E.; Stenborg, G.

2011-04-01

Context. Oscillations of coronal loops in the Sun have been reported in both imaging and spectral observations at the onset of flares. Images reveal transverse oscillations, whereas spectra detect line-of-sight velocity or Doppler-shift oscillations. The Doppler-shift oscillations are commonly interpreted as longitudinal modes. Aims: Our aim is to investigate the relationship between loop dynamics and flows seen in TRACE 195 Å images and Doppler shifts observed by SUMER in Si iii 1113.2 Å and FeXIX 1118.1 Å at the time of a C.8-class limb flare and an associated CME. Methods: We carefully co-aligned the sequence of TRACE 195 Å images to structures seen in the SUMER Si iii, CaX, and FeXIX emission lines. Additionally, Hα observations of a lifting prominence associated with the flare and the coronal mass ejection (CME) are available in three bands around 6563.3 Å. They give constraints on the timing and geometry. Results: Large-scale Doppler-shift oscillations in FeXIX and transverse oscillations in intensity images were observed over a large region of the corona after the passage of a wide bright extreme-ultraviolet (EUV) disturbance, which suggests ionization, heating, and acceleration of hot plasma in the wake of a blast wave. The online movie associated to Fig. 2 is available at http://www.aanda.org and at http://www.mps.mpg.de/data/outgoing/tothova/movie.gif

A low cost Doppler system for vascular dialysis access surveillance.

PubMed

Molina, P S C; Moraes, R; Baggio, J F R; Tognon, E A

2004-01-01

The National Kidney Foundation guidelines for vascular access recommend access surveillance to avoid morbidity among patients undergoing hemodialysis. Methods to detect access failure based on CW Doppler system are being proposed to implement surveillance programs at lower cost. This work describes a low cost Doppler system implemented in a PC notebook designed to carry out this task. A Doppler board samples the blood flow velocity and delivers demodulated quadrature Doppler signals. These signals are sampled by a notebook sound card. Software for Windows OS (running at the notebook) applies CFFT to consecutive 11.6 ms intervals of Doppler signals. The sonogram is presented on the screen in real time. The software also calculates the maximum and the intensity weighted mean frequency envelopes. Since similar systems employ DSP boards to process the Doppler signals, cost reduction was achieved. The Doppler board electronic circuits and routines to process the Doppler signals are presented.

Ballistic Imaging of Liquid Breakup Processes in Dense Sprays

DTIC Science & Technology

2009-06-24

spray breakup in its entirety. Gas-phase flowfield dynamics can be captured via particle image velocimetry (PIV) and/or laser Doppler velocimetry... Coherent Legend Ti:Sapphire regenerative amplifier, seeded with a Spectra-Physics Tsunami Ti:Sapphire mode-locked laser generating 40 fs, 2.5 mJ pulses...scattering turbid media. Laser Phys. Lett., 3(9):464–7, 2006. [44] B. Kaldvee, A. Ehn, J. Bood, and M. Aldén. Development of a picosecond- LIDAR system

Structural Acoustic UXO Detection and Identification in Marine Environments

DTIC Science & Technology

2016-05-01

BOSS Buried Object Scanning Sonar DVL Doppler Velocity Log EW East/West IMU Inertial Measurement Unit NRL Naval Research Laboratory NSWC-PCD... Inertial Measurement Unit (IMU) to time-delay and coherently sum matched-filtered phase histories from subsurface focal points over a large number of... Measurement Unit (IMU) systems. In our imaging algorithm, the 2D depth image of a target, i.e. one mapped over x and z or y and z, presents the

4D microvascular imaging based on ultrafast Doppler tomography.

PubMed

Demené, Charlie; Tiran, Elodie; Sieu, Lim-Anna; Bergel, Antoine; Gennisson, Jean Luc; Pernot, Mathieu; Deffieux, Thomas; Cohen, Ivan; Tanter, Mickael

2016-02-15

4D ultrasound microvascular imaging was demonstrated by applying ultrafast Doppler tomography (UFD-T) to the imaging of brain hemodynamics in rodents. In vivo real-time imaging of the rat brain was performed using ultrasonic plane wave transmissions at very high frame rates (18,000 frames per second). Such ultrafast frame rates allow for highly sensitive and wide-field-of-view 2D Doppler imaging of blood vessels far beyond conventional ultrasonography. Voxel anisotropy (100 μm × 100 μm × 500 μm) was corrected for by using a tomographic approach, which consisted of ultrafast acquisitions repeated for different imaging plane orientations over multiple cardiac cycles. UFT-D allows for 4D dynamic microvascular imaging of deep-seated vasculature (up to 20 mm) with a very high 4D resolution (respectively 100 μm × 100 μm × 100 μm and 10 ms) and high sensitivity to flow in small vessels (>1 mm/s) for a whole-brain imaging technique without requiring any contrast agent. 4D ultrasound microvascular imaging in vivo could become a valuable tool for the study of brain hemodynamics, such as cerebral flow autoregulation or vascular remodeling after ischemic stroke recovery, and, more generally, tumor vasculature response to therapeutic treatment. Copyright © 2015 Elsevier Inc. All rights reserved.

The Surface Brightness Contribution of II Peg: A Comparison of TiO Band Analysis and Doppler Imaging

NASA Astrophysics Data System (ADS)

Senavci, H. V.; O'Neal, D.; Hussain, G. A. J.; Barnes, J. R.

2015-01-01

We investigate the surface brightness contribution of the very well known active SB1 binary II Pegasi , to determine the star spot filling factor and the spot temperature parameters. In this context, we analyze 54 spectra of the system taken over 6 nights in September - October of 1996, using the 2.1m Otto Struve Telescope equipped with SES at the McDonald Observatory. We measure the spot temperatures and spot filling factors by fitting TiO molecular bands in this spectroscopic dataset, with model atmosphere approximation using ATLAS9 and with proxy stars obtained with the same instrument. The same dataset is then used to also produce surface spot maps using the Doppler imaging technique. We compare the spot filling factors obtained with the two independent techniques in order to better characterise the spot properties of the system and to better assess the limitations inherent to both techniques. The results obtained from both techniques show that the variation of spot filling factor as a function of phase agree well with each other, while the amount of TiO and DI spot

Brown dwarf science at Project 1640: the case of HD 19467 B

NASA Astrophysics Data System (ADS)

Aguilar, Jonathan; Crepp, Justin R.; Rice, Emily L.; Pueyo, Laurent; Veicht, Aaron; Nilsson, Ricky; Oppenheimer, Rebecca; Hinkley, Sasha; Brenner, Douglas; Vasisht, Gautam; Cady, Eric; Beichman, Charles A.; Hillenbrand, Lynne; Lockhart, Thomas; Matthews, Christopher T.; Roberts, Lewis C.; Sivaramakrishnan, Anand; Soummer, Remi; Zhai, Chengxing; Giorla, Paige

2015-01-01

Project 1640 is an extreme-AO, coronagraphic, hyperspectral direct-imaging instrument designed to characterize substellar companions in the giant planet to brown dwarf mass regime. It also plays an important role in the TRENDS survey, which targets solar-type stars with Doppler accelerations known to be caused by brown dwarf-sized companions. A recent highlight from TRENDS is HD 19467 B -- this is currently the only directly-imaged benchmark T dwarf known to induce a measurable Doppler acceleration around its host. J- and H-band spectra taken by the Project 1640 integral field spectrograph were fitted against SpeX/IRTF T dwarf standards and synthetic spectra from BT-Settl atmospheric models. Spectral typing classified HD 19467 B as a T5.5±1 brown dwarf with an effective temperature of Teff = 978+20-43 K. The new spectrum helps resolve a previous disagreement about the system age, helping constrain the range of allowed masses for the companion. We expect that new data from the ongoing TRENDS survey will help improve our understanding of brown dwarf atmospheres in high mass ratio systems.

A comparative study of colour and perfusion between two different post surgical scars. Do the laser Doppler imager and the colorimeter measure the same features of a scar?

PubMed

Mermans, J F; Peeters, W J; Dikmans, R; Serroyen, J; van der Hulst, R R J W; Van den Kerckhove, E

2013-05-01

The purpose of this study was to investigate the influence of different located post surgical scars on both perfusion and redness. The pattern of change and correlation between perfusion and redness of post surgical scars is also examined. In this study, we measured redness and perfusion of the abdominal and breast scar of 24 women undergoing breast reconstruction with Deep Inferior Epigastric Perforator Free Flap surgery with the Minolta Chromameter CR-400/410 and the Moor Instruments laser Doppler imager 12IR, respectively, at different intervals post-operatively. The laser Doppler imager gives significantly higher values for the abdominal compared with the breast scar. There was no consistent correlation found between perfusion and redness at the different test moments for both locations. The scores of both parameters were significantly associated after 9 months follow-up for both locations. Scars closed with higher mechanical force show higher perfusion and prolonged activity; and more redness is associated with more perfusion for both post surgical scars. Nevertheless, there was no consistent correlation found between these parameters making the laser Doppler imager and the Colorimeter still non-replaceable instruments. © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.

Ultrafast Ultrasound Imaging of Ocular Anatomy and Blood Flow

PubMed Central

Urs, Raksha; Ketterling, Jeffrey A.; Silverman, Ronald H.

2016-01-01

Purpose Ophthalmic ultrasound imaging is currently performed with mechanically scanned single-element probes. These probes have limited capabilities overall and lack the ability to image blood flow. Linear-array systems are able to detect blood flow, but these systems exceed ophthalmic acoustic intensity safety guidelines. Our aim was to implement and evaluate a new linear-array–based technology, compound coherent plane-wave ultrasound, which offers ultrafast imaging and depiction of blood flow at safe acoustic intensity levels. Methods We compared acoustic intensity generated by a 128-element, 18-MHz linear array operated in conventionally focused and plane-wave modes and characterized signal-to-noise ratio (SNR) and lateral resolution. We developed plane-wave B-mode, real-time color-flow, and high-resolution depiction of slow flow in postprocessed data collected continuously at a rate of 20,000 frames/s. We acquired in vivo images of the posterior pole of the eye by compounding plane-wave images acquired over ±10° and produced images depicting orbital and choroidal blood flow. Results With the array operated conventionally, Doppler modes exceeded Food and Drug Administration safety guidelines, but plane-wave modalities were well within guidelines. Plane-wave data allowed generation of high-quality compound B-mode images, with SNR increasing with the number of compounded frames. Real-time color-flow Doppler readily visualized orbital blood flow. Postprocessing of continuously acquired data blocks of 1.6-second duration allowed high-resolution depiction of orbital and choroidal flow over the cardiac cycle. Conclusions Newly developed high-frequency linear arrays in combination with plane-wave techniques present opportunities for the evaluation of ocular anatomy and blood flow, as well as visualization and analysis of other transient phenomena such as vessel wall motion over the cardiac cycle and saccade-induced vitreous motion. PMID:27428169

Preliminary measurements of the edge magnetic field pitch from 2-D Doppler backscattering in MAST and NSTX-U (invited)

DOE PAGES

Vann, R. G. L.; Brunner, K. J.; Ellis, R.; ...

2016-09-13

The Synthetic Aperture Microwave Imaging (SAMI) system is a novel diagnostic consisting of an array of 8 independently phased antennas. At any one time, SAMI operates at one of the 16 frequencies in the range 10-34.5 GHz. The imaging beam is steered in software post-shot to create a picture of the entire emission surface. In SAMI’s active probing mode of operation, the plasma edge is illuminated with a monochromatic source and SAMI reconstructs an image of the Doppler back-scattered (DBS) signal. By assuming that density fluctuations are extended along magnetic field lines, and knowing that the strongest back-scattered signals aremore » directed perpendicular to the density fluctuations, SAMI’s 2-D DBS imaging capability can be used to measure the pitch of the edge magnetic field. In this paper, we present preliminary pitch angle measurements obtained by SAMI on the Mega Amp Spherical Tokamak (MAST) at Culham Centre for Fusion Energy and on the National Spherical Torus Experiment Upgrade at Princeton Plasma Physics Laboratory. Lastly, the results demonstrate encouraging agreement between SAMI and other independent measurements.« less

In vivo lateral blood flow velocity measurement using speckle size estimation.

PubMed

Xu, Tiantian; Hozan, Mohsen; Bashford, Gregory R

2014-05-01

In previous studies, we proposed blood measurement using speckle size estimation, which estimates the lateral component of blood flow within a single image frame based on the observation that the speckle pattern corresponding to blood reflectors (typically red blood cells) stretches (i.e., is "smeared") if blood flow is in the same direction as the electronically controlled transducer line selection in a 2-D image. In this observational study, the clinical viability of ultrasound blood flow velocity measurement using speckle size estimation was investigated and compared with that of conventional spectral Doppler of carotid artery blood flow data collected from human patients in vivo. Ten patients (six male, four female) were recruited. Right carotid artery blood flow data were collected in an interleaved fashion (alternating Doppler and B-mode A-lines) with an Antares Ultrasound Imaging System and transferred to a PC via the Axius Ultrasound Research Interface. The scanning velocity was 77 cm/s, and a 4-s interval of flow data were collected from each subject to cover three to five complete cardiac cycles. Conventional spectral Doppler data were collected simultaneously to compare with estimates made by speckle size estimation. The results indicate that the peak systolic velocities measured with the two methods are comparable (within ±10%) if the scan velocity is greater than or equal to the flow velocity. When scan velocity is slower than peak systolic velocity, the speckle stretch method asymptotes to the scan velocity. Thus, the speckle stretch method is able to accurately measure pure lateral flow, which conventional Doppler cannot do. In addition, an initial comparison of the speckle size estimation and color Doppler methods with respect to computational complexity and data acquisition time indicated potential time savings in blood flow velocity estimation using speckle size estimation. Further studies are needed for calculation of the speckle stretch method across a field of view and combination with an appropriate axial flow estimator. Copyright © 2014 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

A New Era in Diagnostic Ultrasound, Superb Microvascular Imaging: Preliminary Results in Pediatric Hepato-Gastrointestinal Disorders.

PubMed

Ohno, Yasuharu; Fujimoto, Tamotsu; Shibata, Yukari

2017-02-01

Introduction  Superb microvascular imaging is a new ultrasound image processing technique that uses advanced clutter suppression to extract flow signals from vessels and which helps us visualize very small vascular structures that were not previously visible without the use of a contrast agent. We herein analyzed the usefulness of superb microvascular imaging in the diagnosis of hepato-gastrointestinal disorders in pediatric patients. Materials and Methods  Fifty-six pediatric patients who underwent a total of 81 superb microvascular imaging examinations with an Aplio 300 ultrasound system (Toshiba Medical Systems, Tokyo, Japan) were enrolled in this study. The subjects underwent conventional ultrasound examinations, including Doppler imaging followed by superb microvascular imaging. The superb microvascular imaging findings and standard imaging were compared. All of the examinations were performed without sedation. Results  The average age of the patients (male, n  = 38; female, n  = 18) was 4 years. The clinical diagnoses included hepatobiliary disorders ( n  = 29), acute appendicitis ( n  = 10), and other intestinal disorders ( n  = 17). The target organs for superb microvascular imaging were the liver, appendix, rectum, intestine, gallbladder, and lymph node. In most of the patients, superb microvascular imaging achieved the excellent visualization of microvascular structures, revealing abnormal vasculature in 21 out of 46 (45.7%) examinations of the liver, 9/9 (100%) examinations of the appendix, 0/11 (0%) examinations of the rectum, 9/11 (81.8%) examinations of the intestine, 0/1 (0%) examinations of the gallbladder, and 3/3 (100%) examinations of the lymph nodes. Superb microvascular imaging was superior to Doppler imaging for depicting the microvascular structures. Conclusions  Superb microvascular imaging is especially useful for depicting the microvascular flow and can aid in the diagnosis and treatment planning for pediatric patients with hepato-gastrointestinal disorders. Georg Thieme Verlag KG Stuttgart · New York.

Intracardiac Vortex Dynamics by High-Frame-Rate Doppler Vortography-In Vivo Comparison With Vector Flow Mapping and 4-D Flow MRI.

PubMed

Faurie, Julia; Baudet, Mathilde; Assi, Kondo Claude; Auger, Dominique; Gilbert, Guillaume; Tournoux, Francois; Garcia, Damien

2017-02-01

Recent studies have suggested that intracardiac vortex flow imaging could be of clinical interest to early diagnose the diastolic heart function. Doppler vortography has been introduced as a simple color Doppler method to detect and quantify intraventricular vortices. This method is able to locate a vortex core based on the recognition of an antisymmetric pattern in the Doppler velocity field. Because the heart is a fast-moving organ, high frame rates are needed to decipher the whole blood vortex dynamics during diastole. In this paper, we adapted the vortography method to high-frame-rate echocardiography using circular waves. Time-resolved Doppler vortography was first validated in vitro in an ideal forced vortex. We observed a strong correlation between the core vorticity determined by high-frame-rate vortography and the ground-truth vorticity. Vortography was also tested in vivo in ten healthy volunteers using high-frame-rate duplex ultrasonography. The main vortex that forms during left ventricular filling was tracked during two-three successive cardiac cycles, and its core vorticity was determined at a sampling rate up to 80 duplex images per heartbeat. Three echocardiographic apical views were evaluated. Vortography-derived vorticities were compared with those returned by the 2-D vector flow mapping approach. Comparison with 4-D flow magnetic resonance imaging was also performed in four of the ten volunteers. Strong intermethod agreements were observed when determining the peak vorticity during early filling. It is concluded that high-frame-rate Doppler vortography can accurately investigate the diastolic vortex dynamics.

Microwave imaging of spinning object using orbital angular momentum

NASA Astrophysics Data System (ADS)

Liu, Kang; Li, Xiang; Gao, Yue; Wang, Hongqiang; Cheng, Yongqiang

2017-09-01

The linear Doppler shift used for the detection of a spinning object becomes significantly weakened when the line of sight (LOS) is perpendicular to the object, which will result in the failure of detection. In this paper, a new detection and imaging technique for spinning objects is developed. The rotational Doppler phenomenon is observed by using the microwave carrying orbital angular momentum (OAM). To converge the radiation energy on the area where objects might exist, the generation method of OAM beams is proposed based on the frequency diversity principle, and the imaging model is derived accordingly. The detection method of the rotational Doppler shift and the imaging approach of the azimuthal profiles are proposed, which are verified by proof-of-concept experiments. Simulation and experimental results demonstrate that OAM beams can still be used to obtain the azimuthal profiles of spinning objects even when the LOS is perpendicular to the object. This work remedies the insufficiency in existing microwave sensing technology and offers a new solution to the object identification problem.

Directional ocean wave measurements in a coastal setting using a focused array imaging radar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frasier, S.J.; Liu, Y.; Moller, D.

1995-03-01

A unique focused array imaging Doppler radar was used to measure directional spectra of ocean surface waves in a nearshore experiment performed on the North Carolina Outer Banks. Radar images of the ocean surface`s Doppler velocity were used to generate two dimensional spectra of the radial component of the ocean surface velocity field. These are compared to simultaneous in-situ measurements made by a nearby array of submerged pressure sensors. Analysis of the resulting two-dimensional spectra include comparisons of dominant wave lengths, wave directions, and wave energy accounting for relative differences in water depth at the measurement locations. Limited estimates ofmore » the two-dimensional surface displacement spectrum are derived from the radar data. The radar measurements are analogous to those of interferometric synthetic aperture radars (INSAR), and the equivalent INSAR parameters are shown. The agreement between the remote and in-situ measurements suggests that an imaging Doppler radar is effective for these wave measurements at near grazing incidence angles.« less

Automated assessment of joint synovitis activity from medical ultrasound and power doppler examinations using image processing and machine learning methods.

PubMed

Cupek, Rafal; Ziębiński, Adam

2016-01-01

Rheumatoid arthritis is the most common rheumatic disease with arthritis, and causes substantial functional disability in approximately 50% patients after 10 years. Accurate measurement of the disease activity is crucial to provide an adequate treatment and care to the patients. The aim of this study is focused on a computer aided diagnostic system that supports an assessment of synovitis severity. This paper focus on a computer aided diagnostic system that was developed within joint Polish-Norwegian research project related to the automated assessment of the severity of synovitis. Semiquantitative ultrasound with power Doppler is a reliable and widely used method of assessing synovitis. Synovitis is estimated by ultrasound examiner using the scoring system graded from 0 to 3. Activity score is estimated on the basis of the examiner's experience or standardized ultrasound atlases. The method needs trained medical personnel and the result can be affected by a human error. The porotype of a computer-aided diagnostic system and algorithms essential for an analysis of ultrasonic images of finger joints are main scientific output of the MEDUSA project. Medusa Evaluation System prototype uses bone, skin, joint and synovitis area detectors for mutual structural model based evaluation of synovitis. Finally, several algorithms that support the semi-automatic or automatic detection of the bone region were prepared as well as a system that uses the statistical data processing approach in order to automatically localize the regions of interest. Semiquantitative ultrasound with power Doppler is a reliable and widely used method of assessing synovitis. Activity score is estimated on the basis of the examiner's experience and the result can be affected by a human error. In this paper we presented the MEDUSA project which is focused on a computer aided diagnostic system that supports an assessment of synovitis severity.

In vivo photoacoustic tomography of total blood flow and Doppler angle

NASA Astrophysics Data System (ADS)

Yao, Junjie; Maslov, Konstantin I.; Wang, Lihong V.

2012-02-01

As two hallmarks of cancer, angiogenesis and hypermetabolism are closely related to increased blood flow. Volumetric blood flow measurement is important to understanding the tumor microenvironment and developing new means to treat cancer. Current photoacoustic blood flow estimation methods focus on either the axial or transverse component of the flow vector. Here, we propose a method to compute the total flow speed and Doppler angle by combining the axial and transverse flow measurements. Both the components are measured in M-mode. Collating the A-lines side by side yields a 2D matrix. The columns are Hilbert transformed to compare the phases for the computation of the axial flow. The rows are Fourier transformed to quantify the bandwidth for the computation of the transverse flow. From the axial and transverse flow components, the total flow speed and Doppler angle can be derived. The method has been verified by flowing bovine blood in a plastic tube at various speeds from 0 to 7.5 mm/s and at Doppler angles from 30 to 330°. The measurement error for total flow speed was experimentally determined to be less than 0.3 mm/s; for the Doppler angle, it was less than 15°. In addition, the method was tested in vivo on a mouse ear. The advantage of this method is simplicity: No system modification or additional data acquisition is required to use our existing system. We believe that the proposed method has the potential to be used for cancer angiogenesis and hypermetabolism imaging.

Intraventricular vector flow mapping—a Doppler-based regularized problem with automatic model selection

NASA Astrophysics Data System (ADS)

Assi, Kondo Claude; Gay, Etienne; Chnafa, Christophe; Mendez, Simon; Nicoud, Franck; Abascal, Juan F. P. J.; Lantelme, Pierre; Tournoux, François; Garcia, Damien

2017-09-01

We propose a regularized least-squares method for reconstructing 2D velocity vector fields within the left ventricular cavity from single-view color Doppler echocardiographic images. Vector flow mapping is formulated as a quadratic optimization problem based on an {{\\ell }2} -norm minimization of a cost function composed of a Doppler data-fidelity term and a regularizer. The latter contains three physically interpretable expressions related to 2D mass conservation, Dirichlet boundary conditions, and smoothness. A finite difference discretization of the continuous problem was adopted in a polar coordinate system, leading to a sparse symmetric positive-definite system. The three regularization parameters were determined automatically by analyzing the L-hypersurface, a generalization of the L-curve. The performance of the proposed method was numerically evaluated using (1) a synthetic flow composed of a mixture of divergence-free and curl-free flow fields and (2) simulated flow data from a patient-specific CFD (computational fluid dynamics) model of a human left heart. The numerical evaluations showed that the vector flow fields reconstructed from the Doppler components were in good agreement with the original velocities, with a relative error less than 20%. It was also demonstrated that a perturbation of the domain contour has little effect on the rebuilt velocity fields. The capability of our intraventricular vector flow mapping (iVFM) algorithm was finally illustrated on in vivo echocardiographic color Doppler data acquired in patients. The vortex that forms during the rapid filling was clearly deciphered. This improved iVFM algorithm is expected to have a significant clinical impact in the assessment of diastolic function.

Diagnostic Accuracy of B-mode USG and Doppler Scan for Ovarian Lesions

PubMed Central

Agarwal, Vinish Kumar

2016-01-01

Introduction Ultrasonography (USG) is considered as the primary imaging modality for confirmation of ovarian mass and to differentiate them in to benign or malignant. Aim The present study was conducted with the aim to evaluate accuracy of B- mode USG and Doppler scan (Colour Doppler + Spectral Doppler) for ovarian lesions. Materials and Methods The patients included in the study were from those referred with either palpable adnexal mass or incidentally detected adnexal masses. Total 250 women were evaluated by USG, Doppler scan. Only fifty patients who had true ovarian mass intraoperatively and on histopathology were included in study, rest masses were excluded. Study parameters were morphological indexing on B- Mode USG, flow study, vessel arrangement, and vessel morphology and vessel location in Colour Doppler and resistive index and pulsatility index in spectral Doppler. Results Total 50 women were included in present study. Out of these 46% were pre-menopausal while 54% were menopaused women, 66.7% of post-menopausal women had malignant ovarian masses compared to 8.7% of premenopausal. Sensitivity, specificity, positive predictive value and negative predictive value of B-Mode USG for ovarian masses were 94.44%, 48.15%, 54.84% and 92.86% respectively, with p-value = 0.007, while sensitivity, specificity, positive predictive value and negative predictive value of Doppler scan were 85%, 90%, 85% and 90% respectively, with p-value = 0.0001. Conclusion USG and its different techniques are accepted as the primary imaging modality for early stage diagnosis of an ovarian malignancy. Statistical analysis suggests that Doppler Scan (Colour + Spectral) was more accurate (88%) than B-Mode USG (67%), but author is in view that both of these modalities should be used in conjunction to screen the ovarian lesions. PMID:27790544

Automatic retinal blood flow calculation using spectral domain optical coherence tomography

NASA Astrophysics Data System (ADS)

Wehbe, Hassan; Ruggeri, Marco; Jiao, Shuliang; Gregori, Giovanni; Puliafito, Carmen A.

2008-02-01

Optical Doppler tomography (ODT) is a branch of optical coherence tomography (OCT) that can measure the speed of a blood flow by measuring the Doppler shift impinged on the probing sample light by the moving blood cells. However, the measured speed of blood flow is a function of the Doppler angle, which needs to be determined in order to calculate the absolute velocity of the blood flow inside a vessel. We developed a technique that can extract the Doppler angle from the 3D data measured with spectral-domain OCT, which needs to extract the lateral and depth coordinates of a vessel in each measured ODT and OCT image. The lateral coordinates and the diameter of a blood vessel were first extracted in each OCT structural image by using the technique of blood vessel shadowgram, a technique first developed by us for enhancing the retinal blood vessel contrast in the en face view of the 3D OCT. The depth coordinate of a vessel was then determined by using a circular averaging filter moving in the depth direction along the axis passing through the vessel center in the ODT image. The Doppler angle was then calculated from the extracted coordinates of the blood vessel. The technique was applied in blood flow measurements in retinal blood vessels, which has potential impact on the study and diagnosis of blinding diseases like glaucoma and diabetic retinopathy.

Standardised imaging technique for guided M-mode and Doppler echocardiography in the horse.

PubMed

Long, K J; Bonagura, J D; Darke, P G

1992-05-01

Eighteen echocardiographic images useful for diagnostic imaging, M-mode echocardiography, and Doppler echocardiography of the equine heart were standardised by relating the position of the axial beam to various intracardiac landmarks. The transducer orientation required for each image was recorded in 14 adult horses by describing the degree of sector rotation and the orientation of the axial beam relative to the thorax. Repeatable images could be obtained within narrow limits of angulation and rotation for 14 of the 18 standardised images evaluated. Twenty-seven National Hunt horses were subsequently examined using this standardised technique. Selected cardiac dimensions were measured from two-dimensional and guided M-mode studies. Satisfactory results were achieved in 26 of the 27 horses. There was no linear correlation between any of the measured cardiac values and bodyweight. There was no significant difference between measurements taken from the left and the right hemithorax. Six horses were imaged on three consecutive days to assess the repeatability of the measurements. No significant difference was found between measurements obtained on different days. This study demonstrates a method for standardised echocardiographic evaluation of the equine heart that is repeatable, valuable for teaching techniques of equine echocardiography, applicable for diagnostic imaging and quantification of cardiac size, and useful for the evaluation of blood-flow patterns by Doppler ultrasound.

Development of a Duplex Ultrasound Simulator and Preliminary Validation of Velocity Measurements in Carotid Artery Models.

PubMed

Zierler, R Eugene; Leotta, Daniel F; Sansom, Kurt; Aliseda, Alberto; Anderson, Mark D; Sheehan, Florence H

2016-07-01

Duplex ultrasound scanning with B-mode imaging and both color Doppler and Doppler spectral waveforms is relied upon for diagnosis of vascular pathology and selection of patients for further evaluation and treatment. In most duplex ultrasound applications, classification of disease severity is based primarily on alterations in blood flow velocities, particularly the peak systolic velocity (PSV) obtained from Doppler spectral waveforms. We developed a duplex ultrasound simulator for training and assessment of scanning skills. Duplex ultrasound cases were prepared from 2-dimensional (2D) images of normal and stenotic carotid arteries by reconstructing the common carotid, internal carotid, and external carotid arteries in 3 dimensions and computationally simulating blood flow velocity fields within the lumen. The simulator displays a 2D B-mode image corresponding to transducer position on a mannequin, overlaid by color coding of velocity data. A spectral waveform is generated according to examiner-defined settings (depth and size of the Doppler sample volume, beam steering, Doppler beam angle, and pulse repetition frequency or scale). The accuracy of the simulator was assessed by comparing the PSV measured from the spectral waveforms with the true PSV which was derived from the computational flow model based on the size and location of the sample volume within the artery. Three expert examiners made a total of 36 carotid artery PSV measurements based on the simulated cases. The PSV measured by the examiners deviated from true PSV by 8% ± 5% (N = 36). The deviation in PSV did not differ significantly between artery segments, normal and stenotic arteries, or examiners. To our knowledge, this is the first simulation of duplex ultrasound that can create and display real-time color Doppler images and Doppler spectral waveforms. The results demonstrate that an examiner can measure PSV from the spectral waveforms using the settings on the simulator with a mean absolute error in the velocity measurement of less than 10%. With the addition of cases with a range of pathologies, this duplex ultrasound simulator will be a useful tool for training health-care providers in vascular ultrasound applications and for assessing their skills in an objective and quantitative manner. © The Author(s) 2016.

Doppler and range determination for deep space vehicles using active optical transponders.

PubMed

Kinman, P W; Gagliardi, R M

1988-11-01

This paper describes and analyzes two types of laser system employing active transponders that could accurately determine Doppler and range to deep space vehicles from earth-orbiting satellites. The first is a noncoherent optical system in which the Doppler effect on an intensity-modulating subcarrier is measured. The second is a coherent optical system in which the Doppler effect of the optical carrier itself is measured. Doppler and range measurement errors are mathematically modeled and, for three example systems, numerically evaluated.

Doppler and range determination for deep space vehicles using active optical transponders

NASA Technical Reports Server (NTRS)

Kinman, Peter W.; Gagliardi, Robert M.

1988-01-01

This paper describes and analyzes two types of laser system employing active transponders that could accurately determine Doppler and range to deep space vehicles from earth-orbiting satellites. The first is a noncoherent optical system in which the Doppler effect on an intensity-modulating subcarrier is measured. The second is a coherent optical system in which the Doppler effect of the optical carrier itself is measured. Doppler and range measurement errors are mathematically modeled and, for three example systems, numerically evaluated.

Doppler echocardiographic evaluation of midventricular obstruction in cats with hypertrophic cardiomyopathy.

PubMed

MacLea, H B; Boon, J A; Bright, J M

2013-01-01

Hypertrophic cardiomyopathy (HCM) is heterogeneous in both people and cats, with variability in the distribution of hypertrophy, hemodynamic characteristics, and Doppler echocardiographic findings. To document the Doppler echocardiographic characteristics of midventricular obstruction in some cats with HCM. Eight cats with hypertrophic cardiomyopathy. Retrospective case series. The medical records of cats presenting to the cardiology service at Colorado State University between February 2009 and January 2012 were reviewed. All cats had a physical examination; Doppler systolic blood pressure measurement; and transthoracic two-dimensional (2D), M-mode, and Doppler echocardiography were performed. A more thorough evaluation of the echocardiographic images and measurements was performed. Cats included in this study had echocardiograms of adequate quality to confirm the diagnosis of midventricular obstruction by documentation of left midventricular concentric hypertrophy; a midventricular turbulent Doppler color flow pattern; and high velocity, late-peaking flow at the area of turbulence. Cats with evidence of systemic hypertension defined as a systolic Doppler blood pressure of greater than 170 mmHg were excluded. All 8 cats had left ventricular hypertrophy at the level of the papillary muscles; left, midventricular hypertrophy; and in 4/8 cats there was apical hypertrophy or basilar hypertrophy of the interventricular septum. Color flow Doppler revealed turbulent flow in 8/8 cats and spectral Doppler (continuous and pulsed wave) revealed increased flow velocities and late-peaking flow profiles at the level of the left midventricle. Two of 8 cats had a bifid midventricular flow profile in which there was a midsystolic decline in left ventricular velocities with elevated velocities extending into early diastole. The peak left ventricular outflow velocity in all 8 cats was normal. A variant of HCM characterized by hypertrophy at the level of the papillary muscles with midventricular obstruction is present in some cats. Recognition of this variant of feline HCM allows identification of HCM in cats with murmurs where the more classic features of HCM are not present. Copyright © 2013 by the American College of Veterinary Internal Medicine.

A new method for blood velocity measurements using ultrasound FMCW signals.

PubMed

Kunita, Masanori; Sudo, Masamitsu; Inoue, Shinya; Akahane, Mutsuhiro

2010-05-01

The low peak power of frequency-modulated continuous wave (FMCW) radar makes it attractive for various applications, including vehicle collision warning systems and airborne radio altimeters. This paper describes a new ultrasound Doppler measurement system that measures blood flow velocity based on principles similar to those of FMCW radar. We propose a sinusoidal wave for FM modulation and introduce a new demodulation technique for obtaining Doppler information with high SNR and range resolution. Doppler signals are demodulated with a reference FMCW signal to adjust delay times so that they are equal to propagation times between the transmitter and the receiver. Analytical results suggest that Doppler signals can be obtained from a selected position, as with a sample volume in pulse wave Doppler systems, and that the resulting SNR is nearly identical to that obtained with continuous wave (CW) Doppler systems. Additionally, clutter power is less than that of CW Doppler systems. The analytical results were verified by experiments involving electronic circuits and Doppler ultrasound phantoms.

Structural Acoustic UXO Detection and Identification in Marine Environments - Interim Report for SERDP MR-2103 Follow-On

DTIC Science & Technology

2015-07-30

into the image processing algorithm the AUV position data available from the Doppler Velocity Log (DVL) and Inertial Measurement Unit ( IMU ) systems...uncertainty due to unknown sensor z coordinates. We considered both AUV altitude and roll but not pitch which we assumed to have a small effect on the...buried target. Taken together, the images suggest that the block is buried horizontally but rolled along its long axis ~80° such that the exposed large

4D in vivo ultrafast ultrasound imaging using a row-column addressed matrix and coherently-compounded orthogonal plane waves

NASA Astrophysics Data System (ADS)

Flesch, M.; Pernot, M.; Provost, J.; Ferin, G.; Nguyen-Dinh, A.; Tanter, M.; Deffieux, T.

2017-06-01

4D ultrafast ultrasound imaging was recently shown using a 2D matrix (i.e. fully populated) connected to a 1024-channel ultrafast ultrasound scanner. In this study, we investigate the row-column addressing (RCA) matrix approach, which allows a reduction of independent channels from N  ×  N to N  +  N, with a dedicated beamforming strategy for ultrafast ultrasound imaging based on the coherent compounding of orthogonal plane wave (OPW). OPW is based on coherent compounding of plane wave transmissions in one direction with receive beamforming along the orthogonal direction and its orthogonal companion sequence. Such coherent recombination of complementary orthogonal sequences leads to the virtual transmit focusing in both directions which results into a final isotropic point spread function (PSF). In this study, a 32  ×  32 2D matrix array probe (1024 channels), centered at 5 MHz was considered. An RCA array, of same footprint with 32  +  32 elements (64 channels), was emulated by summing the elements either along a line or a column in software prior to beamforming. This approach allowed for the direct comparison of the 32  +  32 RCA scheme to the optimal fully sampled 32  ×  32 2D matrix configuration, which served as the gold standard. This approach was first studied through PSF simulations and then validated experimentally on a phantom consisting of anechoic cysts and echogenic wires. The contrast-to-noise ratio and the lateral resolution of the RCA approach were found to be approximately equal to half (in decibel) and twice the values, respectively, obtained when using the 2D matrix approach. Results in a Doppler phantom and the human humeral artery in vivo confirmed that ultrafast Doppler imaging can be achieved with reduced performances when compared against the equivalent 2D matrix. Volumetric anatomic Doppler rendering and voxel-based pulsed Doppler quantification are presented as well. OPW compound imaging using emulated RCA matrix can achieve a power Doppler with sufficient contrast to recover the vein shape and provides an accurate Doppler spectrum.

4D in vivo ultrafast ultrasound imaging using a row-column addressed matrix and coherently-compounded orthogonal plane waves.

PubMed

Flesch, M; Pernot, M; Provost, J; Ferin, G; Nguyen-Dinh, A; Tanter, M; Deffieux, T

2017-06-07

4D ultrafast ultrasound imaging was recently shown using a 2D matrix (i.e. fully populated) connected to a 1024-channel ultrafast ultrasound scanner. In this study, we investigate the row-column addressing (RCA) matrix approach, which allows a reduction of independent channels from N  ×  N to N  +  N, with a dedicated beamforming strategy for ultrafast ultrasound imaging based on the coherent compounding of orthogonal plane wave (OPW). OPW is based on coherent compounding of plane wave transmissions in one direction with receive beamforming along the orthogonal direction and its orthogonal companion sequence. Such coherent recombination of complementary orthogonal sequences leads to the virtual transmit focusing in both directions which results into a final isotropic point spread function (PSF). In this study, a 32  ×  32 2D matrix array probe (1024 channels), centered at 5 MHz was considered. An RCA array, of same footprint with 32  +  32 elements (64 channels), was emulated by summing the elements either along a line or a column in software prior to beamforming. This approach allowed for the direct comparison of the 32  +  32 RCA scheme to the optimal fully sampled 32  ×  32 2D matrix configuration, which served as the gold standard. This approach was first studied through PSF simulations and then validated experimentally on a phantom consisting of anechoic cysts and echogenic wires. The contrast-to-noise ratio and the lateral resolution of the RCA approach were found to be approximately equal to half (in decibel) and twice the values, respectively, obtained when using the 2D matrix approach. Results in a Doppler phantom and the human humeral artery in vivo confirmed that ultrafast Doppler imaging can be achieved with reduced performances when compared against the equivalent 2D matrix. Volumetric anatomic Doppler rendering and voxel-based pulsed Doppler quantification are presented as well. OPW compound imaging using emulated RCA matrix can achieve a power Doppler with sufficient contrast to recover the vein shape and provides an accurate Doppler spectrum.

Comparison of phase-contrast MR imaging and endovascular sonography for intracranial blood flow velocity measurements.

PubMed

Schneiders, J J; Ferns, S P; van Ooij, P; Siebes, M; Nederveen, A J; van den Berg, R; van Lieshout, J; Jansen, G; vanBavel, E; Majoie, C B

2012-10-01

Local hemodynamic information may help to stratify rupture risk of cerebral aneurysms. Patient-specific modeling of cerebral hemodynamics requires accurate data on BFV in perianeurysmal arteries as boundary conditions for CFD. The aim was to compare the BFV measured with PC-MR imaging with that obtained by using intra-arterial Doppler sonography and to determine interpatient variation in intracranial BFV. In 10 patients with unruptured intracranial aneurysms, BFV was measured in the cavernous ICA with PC-MR imaging in conscious patients before treatment, and measured by using an intra-arterial Doppler sonography wire when the patient was anesthetized with either propofol (6 patients) or sevoflurane (4 patients). Both techniques identified a pulsatile blood flow pattern in cerebral arteries. PSV differed >50 cm/s between patients. A mean velocity of 41.3 cm/s (95% CI, 39.3-43.3) was measured with PC-MR imaging. With intra-arterial Doppler sonography, a mean velocity of 29.3 cm/s (95% CI, 25.8-32.8) was measured with the patient under propofol-based intravenous anesthesia. In patients under sevoflurane-based inhaled anesthesia, a mean velocity of 44.9 cm/s (95% CI, 40.6-49.3) was measured. We showed large differences in BFV between patients, emphasizing the importance of using patient-specific hemodynamic boundary conditions in CFD. PC-MR imaging measurements of BFV in conscious patients were comparable with those obtained with the intra-arterial Doppler sonography when the patient was anesthetized with a sevoflurane-based inhaled anesthetic.

Association Between Echocardiography Laboratory Accreditation and the Quality of Imaging and Reporting for Valvular Heart Disease.

PubMed

Thaden, Jeremy J; Tsang, Michael Y; Ayoub, Chadi; Padang, Ratnasari; Nkomo, Vuyisile T; Tucker, Stephen F; Cassidy, Cynthia S; Bremer, Merri; Kane, Garvan C; Pellikka, Patricia A

2017-08-01

It is presumed that echocardiographic laboratory accreditation leads to improved quality, but there are few data. We sought to compare the quality of echocardiographic examinations performed at accredited versus nonaccredited laboratories for the evaluation of valvular heart disease. We enrolled 335 consecutive valvular heart disease subjects who underwent echocardiography at our institution and an external accredited or nonaccredited institution within 6 months. Completeness and quality of echocardiographic reports and images were assessed by investigators blinded to the external laboratory accreditation status and echocardiographic results. Compared with nonaccredited laboratories, accredited sites more frequently reported patient sex (94% versus 78%; P <0.001), height and weight (96% versus 63%; P <0.001), blood pressure (86% versus 39%; P <0.001), left ventricular size (96% versus 83%; P <0.001), right ventricular size (94% versus 80%; P =0.001), and right ventricular function (87% versus 73%; P =0.006). Accredited laboratories had higher rates of complete and diagnostic color (58% versus 35%; P =0.002) and spectral Doppler imaging (45% versus 21%; P <0.0001). Concordance between external and internal grading of external studies was improved when diagnostic quantification was performed (85% versus 69%; P =0.003), and in patients with mitral regurgitation, reproducibility was improved with higher quality color Doppler imaging. Accredited echocardiographic laboratories had more complete reporting and better image quality, while echocardiographic quantification and color Doppler image quality were associated with improved concordance in grading valvular heart disease. Future quality improvement initiatives should highlight the importance of high-quality color Doppler imaging and echocardiographic quantification to improve the accuracy, reproducibility, and quality of echocardiographic studies for valvular heart disease. © 2017 American Heart Association, Inc.

Surface Charge Measurement of SonoVue, Definity and Optison: A Comparison of Laser Doppler Electrophoresis and Micro-Electrophoresis.

PubMed

Ja'afar, Fairuzeta; Leow, Chee Hau; Garbin, Valeria; Sennoga, Charles A; Tang, Meng-Xing; Seddon, John M

2015-11-01

Microbubble (MB) contrast-enhanced ultrasonography is a promising tool for targeted molecular imaging. It is important to determine the MB surface charge accurately as it affects the MB interactions with cell membranes. In this article, we report the surface charge measurement of SonoVue, Definity and Optison. We compare the performance of the widely used laser Doppler electrophoresis with an in-house micro-electrophoresis system. By optically tracking MB electrophoretic velocity in a microchannel, we determined the zeta potentials of MB samples. Using micro-electrophoresis, we obtained zeta potential values for SonoVue, Definity and Optison of -28.3, -4.2 and -9.5 mV, with relative standard deviations of 5%, 48% and 8%, respectively. In comparison, laser Doppler electrophoresis gave -8.7, +0.7 and +15.8 mV with relative standard deviations of 330%, 29,000% and 130%, respectively. We found that the reliability of laser Doppler electrophoresis is compromised by MB buoyancy. Micro-electrophoresis determined zeta potential values with a 10-fold improvement in relative standard deviation. Copyright © 2015 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

Doppler optical coherence microscopy and tomography applied to inner ear mechanics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Page, Scott; Freeman, Dennis M.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts

While it is clear that cochlear traveling waves underlie the extraordinary sensitivity, frequency selectivity, and dynamic range of mammalian hearing, the underlying micromechanical mechanisms remain unresolved. Recent advances in low coherence measurement techniques show promise over traditional laser Doppler vibrometry and video microscopy, which are limited by low reflectivities of cochlear structures and restricted optical access. Doppler optical coherence tomography (DOCT) and Doppler optical coherence microscopy (DOCM) both utilize a broadband source to limit constructive interference of scattered light to a small axial depth called a coherence gate. The coherence gate can be swept axially to image and measure sub-nanometermore » motions of cochlear structures throughout the cochlear partition. The coherence gate of DOCT is generally narrower than the confocal gate of the focusing optics, enabling increased axial resolution (typically 15 μm) within optical sections of the cochlear partition. DOCM, frequently implemented in the time domain, centers the coherence gate on the focal plane, achieving enhanced lateral and axial resolution when the confocal gate is narrower than the coherence gate. We compare these two complementary systems and demonstrate their utility in studying cellular and micromechanical mechanisms involved in mammalian hearing.« less

Proceedings of the XXII A.I.VE.LA. National Meeting

NASA Astrophysics Data System (ADS)

Primo Tomasini, Enrico

2015-11-01

A.I.VE.LA. - the Italian Association of Laser Velocimetry and non-invasive diagnostics - is a non-profit cultural association whose objective is to promote and support research in the field of non-contact or minimally invasive measurement techniques, particularly electromagnetic-based techniques and optical techniques. Through its Annual Meeting, AIVELA aims to create an active and stimulating forum where current research results and technical advances can be exchanged and the development of new systems for laboratory use, field testing and industrial application can be promoted. The techniques covered include Laser Doppler Anemometry - LDA, Phase Doppler Anemometry - PDA, Image Velocimetry - PIV, Flow visualization techniques, Spectroscopic measurement techniques (LIF, Raman, etc.), Laser Doppler Vibrometry - LDV, Speckle Pattern Interferometry - ESPI, Holographic techniques, Shearography, Digital Image Correlation - DIC, Moiré techniques, Structured light techniques, Infrared imaging, Photoelasticity, Image based measurement techniques, Ultrasonic sensing, Acoustic and Aeroacoustic measurements, etc. The first Annual Meeting was held back in October 1992 and since then there has been a large consensus among the research and scientific communities that the papers presented at the event are of a high scientific interest. The XXII AIVELA Annual Meeting was held at the Faculty of Engineering of University of Rome Tor Vergata on 15-16 December 2014 and was organised in collaboration with the International Master Courses in "Protection Against CBRNe Events". This volume contains a selection of the papers presented at the event. The detailed Programme of the Meeting can be found at: http://www.aivela.org/XXII_Convegno/index.html Trusting our Association and its initiatives will meet your interest, I wish to thank you in advance for your kind attention and hope to meet you soon at one of our events.

Color Doppler imaging of the retrobulbar vessels in diabetic retinopathy.

PubMed

Pauk-Domańska, Magdalena; Walasik-Szemplińska, Dorota

2014-03-01

Diabetes is a metabolic disease characterized by elevated blood glucose level due to impaired insulin secretion and activity. Chronic hyperglycemia leads to functional disorders of numerous organs and to their damage. Vascular lesions belong to the most common late complications of diabetes. Microangiopathic lesions can be found in the eyeball, kidneys and nervous system. Macroangiopathy is associated with coronary and peripheral vessels. Diabetic retinopathy is the most common microangiopathic complication characterized by closure of slight retinal blood vessels and their permeability. Despite intensive research, the pathomechanism that leads to the development and progression of diabetic retinopathy is not fully understood. The examinations used in assessing diabetic retinopathy usually involve imaging of the vessels in the eyeball and the retina. Therefore, the examinations include: fluorescein angiography, optical coherence tomography of the retina, B-mode ultrasound imaging, perimetry and digital retinal photography. There are many papers that discuss the correlations between retrobulbar circulation alterations and progression of diabetic retinopathy based on Doppler sonography. Color Doppler imaging is a non-invasive method enabling measurements of blood flow velocities in small vessels of the eyeball. The most frequently assessed vessels include: the ophthalmic artery, which is the first branch of the internal carotid artery, as well as the central retinal vein and artery, and the posterior ciliary arteries. The analysis of hemodynamic alterations in the retrobulbar vessels may deliver important information concerning circulation in diabetes and help to answer the question whether there is a relation between the progression of diabetic retinopathy and the changes observed in blood flow in the vessels of the eyeball. This paper presents the overview of literature regarding studies on blood flow in the vessels of the eyeball in patients with diabetic retinopathy.

High PRF ultrafast sliding compound doppler imaging: fully qualitative and quantitative analysis of blood flow

NASA Astrophysics Data System (ADS)

Kang, Jinbum; Jang, Won Seuk; Yoo, Yangmo

2018-02-01

Ultrafast compound Doppler imaging based on plane-wave excitation (UCDI) can be used to evaluate cardiovascular diseases using high frame rates. In particular, it provides a fully quantifiable flow analysis over a large region of interest with high spatio-temporal resolution. However, the pulse-repetition frequency (PRF) in the UCDI method is limited for high-velocity flow imaging since it has a tradeoff between the number of plane-wave angles (N) and acquisition time. In this paper, we present high PRF ultrafast sliding compound Doppler imaging method (HUSDI) to improve quantitative flow analysis. With the HUSDI method, full scanline images (i.e. each tilted plane wave data) in a Doppler frame buffer are consecutively summed using a sliding window to create high-quality ensemble data so that there is no reduction in frame rate and flow sensitivity. In addition, by updating a new compounding set with a certain time difference (i.e. sliding window step size or L), the HUSDI method allows various Doppler PRFs with the same acquisition data to enable a fully qualitative, retrospective flow assessment. To evaluate the performance of the proposed HUSDI method, simulation, in vitro and in vivo studies were conducted under diverse flow circumstances. In the simulation and in vitro studies, the HUSDI method showed improved hemodynamic representations without reducing either temporal resolution or sensitivity compared to the UCDI method. For the quantitative analysis, the root mean squared velocity error (RMSVE) was measured using 9 angles (-12° to 12°) with L of 1-9, and the results were found to be comparable to those of the UCDI method (L  =  N  =  9), i.e.  ⩽0.24 cm s-1, for all L values. For the in vivo study, the flow data acquired from a full cardiac cycle of the femoral vessels of a healthy volunteer were analyzed using a PW spectrogram, and arterial and venous flows were successfully assessed with high Doppler PRF (e.g. 5 kHz at L  =  4). These results indicate that the proposed HUSDI method can improve flow visualization and quantification with a higher frame rate, PRF and flow sensitivity in cardiovascular imaging.

High PRF ultrafast sliding compound doppler imaging: fully qualitative and quantitative analysis of blood flow.

PubMed

Kang, Jinbum; Jang, Won Seuk; Yoo, Yangmo

2018-02-09

Ultrafast compound Doppler imaging based on plane-wave excitation (UCDI) can be used to evaluate cardiovascular diseases using high frame rates. In particular, it provides a fully quantifiable flow analysis over a large region of interest with high spatio-temporal resolution. However, the pulse-repetition frequency (PRF) in the UCDI method is limited for high-velocity flow imaging since it has a tradeoff between the number of plane-wave angles (N) and acquisition time. In this paper, we present high PRF ultrafast sliding compound Doppler imaging method (HUSDI) to improve quantitative flow analysis. With the HUSDI method, full scanline images (i.e. each tilted plane wave data) in a Doppler frame buffer are consecutively summed using a sliding window to create high-quality ensemble data so that there is no reduction in frame rate and flow sensitivity. In addition, by updating a new compounding set with a certain time difference (i.e. sliding window step size or L), the HUSDI method allows various Doppler PRFs with the same acquisition data to enable a fully qualitative, retrospective flow assessment. To evaluate the performance of the proposed HUSDI method, simulation, in vitro and in vivo studies were conducted under diverse flow circumstances. In the simulation and in vitro studies, the HUSDI method showed improved hemodynamic representations without reducing either temporal resolution or sensitivity compared to the UCDI method. For the quantitative analysis, the root mean squared velocity error (RMSVE) was measured using 9 angles (-12° to 12°) with L of 1-9, and the results were found to be comparable to those of the UCDI method (L  =  N  =  9), i.e.  ⩽0.24 cm s -1 , for all L values. For the in vivo study, the flow data acquired from a full cardiac cycle of the femoral vessels of a healthy volunteer were analyzed using a PW spectrogram, and arterial and venous flows were successfully assessed with high Doppler PRF (e.g. 5 kHz at L  =  4). These results indicate that the proposed HUSDI method can improve flow visualization and quantification with a higher frame rate, PRF and flow sensitivity in cardiovascular imaging.

Synergic effects of renin and aldosterone on right ventricular function in hypertension: a tissue Doppler study.

PubMed

Gregori, Mario; Giammarioli, Benedetta; Tocci, Giuliano; Befani, Alberto; Ciavarella, Giuseppino Massimo; Ferrucci, Andrea; Paneni, Francesco

2015-12-01

Right ventricular dysfunction (RVD) is associated with poor cardiovascular outcome. The renin-angiotensin-aldosterone system is involved in alterations of the left ventricular geometry and function. Detrimental effects of the renin-angiotensin-aldosterone system on the right ventricular function are being postulated, but data supporting this assumption are still lacking. The aim of the study was to assess the impact of hyperreninemia, hyperaldosteronism or their combination on right ventricular function in hypertensive individuals. Plasma renin activity (PRA) and plasma aldosterone concentrations (PACs) were measured in 116 hypertensive patients, divided as follows: normal PRA and PAC (n = 38); high PRA and normal PAC (hypereninemia) (n = 26); normal PRA and high PAC (hyperaldosternism) (n = 27); high PRA and PAC (HRA) (n = 25). Echocardiographic evaluation of the left and right ventricles (RV), including tissue Doppler imaging, was performed. RVD was identified by tissue Doppler Imaging-derived Myocardial Performance Index, calculated with a multisegmental approach. Indices of the right ventricular structure and function, as well as the prevalence of RVD, were higher in hyperreninemia and hyperaldosternism groups as compared with the normal group, and a further increase was observed in the HRA patients. Regression models showed a similar risk of RVD in the hyperreninemia and hyperaldosternism patients, regardless of systemic and pulmonary pressure, as well as left ventricular dysfunction. Notably, patients with both hyperreninemia and hyperaldosternism exhibited the strongest association with RVD as compared with patients with only hyperreninemia or hyperaldosternism. Isolated hyperreninemia or hyperaldosternism determines a similar impairment of the right ventricular function, whereas their combination is further detrimental. Renin and aldosterone may represent early biomarkers of right ventricular dysfunction in hypertension.

Servomechanism for Doppler shift compensation in optical correlator for synthetic aperture radar

NASA Technical Reports Server (NTRS)

Constaninides, N. J.; Bicknell, T. J. (Inventor)

1980-01-01

A method and apparatus for correcting Doppler shifts in synthetic aperture radar data is described. An optical correlator for synthetic aperture radar data has a means for directing a laser beam at a signal film having radar return pulse intensity information recorded on it. A resultant laser beam passes through a range telescope, an azimuth telescope, and a Fourier transform filter located between the range and azimuth telescopes, and forms an image for recording on an image film. A compensation means for Doppler shift in the radar return pulse intensity information includes a beam splitter for reflecting the modulated laser beam, after having passed through the Fourier transform filter, to a detection screen having two photodiodes mounted on it.

Three-dimensional high-definition flow in the diagnosis of placental lakes.

PubMed

Inubashiri, Eisuke; Deguchi, Keizou; Abe, Kiyotaka; Saitou, Atushi; Watanabe, Yukio; Akutagawa, Noriyuki; Kuroki, Katumaru; Sugawara, Masaki; Maeda, Nobuhiko

2014-10-01

Placental lakes are sonolucent areas often found in the normal placenta. Most of them are asymptomatic. They are sometimes related to placenta accreta or intrauterine fetal growth restriction, among other conditions. Although Doppler sonography is useful for evaluating noxious placental lakes, it is not easy to adapt Doppler studies to conventional two-dimensional color Doppler sonography because of the low-velocity blood flow and high vascularity in the placenta. Here, we demonstrate how three-dimensional high-definition imaging of flow provides a novel visual depiction of placental lakes, which helps substantially with the differential diagnosis. As far as we know, there have been no previous reports of observation of placental lakes using three-dimensional high-definition imaging of flow.

Clinical use of ultrasonography associated with color Doppler in the diagnosis and follow-up of acute pyelonephritis.

PubMed

Dell'Atti, Lucio; Borea, Pier Andrea; Ughi, Gianni; Russo, Gian Rosario

2010-12-01

The purpose of this study is to evaluate the current role of the Ultrasound associated with the color-Doppler in the diagnosis of acute pyelonephritis (APN) and to compare ultrasound images with CT images in order to reduce the amount radiation absorbe without significant loss of diagnostic efficacy, since this disease in most cases affects young adults. We studied 38 patients (aged 17-65 years) who presented from September 2007 to March 2010 to the emergency department with suspected diagnosis of APN. All patients underwent first to an ultrasound study, then to abdominal CT. Renal, perirenal and extrarenal tomographic findings usually associated with acute pyelonephritis were analyzed, in an attempt to identify what are the differences with respect to the images obtained with an ultrasound study. All patients then performed ultrasonography and/or abdominal CT evaluation one month later, 25 patients repeated both examinations, while the other 13 repeated only ultrasound. In 38 subjects with suspected APN, CT assessed the presence in 79% and in 21% the absence of the disease. Ultrasonography in 68% of cases diagnosed APN, by an increase in kidney size related to the presence of hypoechoic areas associated to edema, blurred margins and reduction of the color-Doppler vascularity. Ultrasound associated with the use of color-Doppler revealed a sensibility of 76% and specificity of 75%. Color and power-Doppler have better diagnostic accuracy than basic gray scale ultrasound, in the diagnosis of focal pyelonephritis. Therefore the combined use of ultrasound and color-Doppler can obtain useful information about the diagnosis and follow-up of the disease, with an improvement in terms of cost, without significantly altering the diagnostic efficacy and reducing the amount of radiation absorbed.

[Role of cardiac magnetic resonance in cardiac involvement of Fabry disease].

PubMed

Serra, Viviana M; Barba, Miguel Angel; Torrá, Roser; Pérez De Isla, Leopoldo; López, Mónica; Calli, Andrea; Feltes, Gisela; Torras, Joan; Valverde, Victor; Zamorano, José L

2010-09-04

Fabry disease is a hereditary disorder. Clinical manifestations are multisystemic. The majority of the patients remain undiagnosed until late in life, when alterations could be irreversible. Early detection of cardiac symptoms is of major interest in Fabry's disease (FD) in order to gain access to enzyme replacement therapy. Echo-Doppler tissular imaging (TDI) has been used as a cardiologic early marker in FD. This study is intended to determine whether the cardiac magnetic resonance is as useful tool as TDI for the early detection of cardiac affectation in FD. Echocardiography, tissue Doppler and Cardio magnetic resonance was performed in 20 patients with confirmed Fabry Disease. Left ventricular hypertrophy was defined as septum and left ventricular posterior wall thickness ≥12 mm. An abnormal TDI velocity was defined as (Sa), (Ea) and/or (Aa) velocities <8 cm/s at either the septal or lateral corner. Late phase gadolinium-enhanced images sequences were obtained using magnetic resonance. Twenty patients included in the study were divided into three groups: 1. Those without left ventricular hypertrophy nor tissue Doppler impairment 2. Those without left ventricular hypertrophy and tissue Doppler impairment 3. Those with left ventricular hypertrophy and Tissue Doppler impairment. Late gadolinium enhancement was found in only one patient, who has already altered DTI and LVH. Tissue Doppler imaging (TDI) is the only diagnostic tool able to provide early detection of cardiac affectation in patients with FD. Magnetic resonance provides information of the disease severity in patients with LVH, but can not be used as an early marker of cardiac disease in patients with FD. However MRI could be of great value for diagnostic stratification. Copyright © 2009 Elsevier España, S.L. All rights reserved.

Applying Zeeman Doppler imaging to solar spectra

NASA Astrophysics Data System (ADS)

Hussain, G. A. J.; Saar, S. H.; Collier Cameron, A.

2004-03-01

A new generation of spectro-polarimeters with high throughput (e.g. CFHT/ESPADONS and LBT/PEPSI) is becoming available. This opportunity can be exploited using Zeeman Doppler imaging (ZDI), a technique that inverts time-series of Stokes V spectra to map stellar surface magnetic fields (Semel 1989). ZDI is assisted by ``Least squares deconvolution'' (LSD), which sums up the signal from 1000's of photospheric lines to produce a mean deconvolved profile with higher S:N (Donati & Collier Cameron 1997).

Planet Formation Instrument for the Thirty Meter Telescope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Macintosh, B; Troy, M; Graham, J

2006-02-22

In the closing years of the 20th Century humankind began its exploration of the planetary systems in the solar neighborhood. Precision radial velocity measurements have now yielded the discovery of over 160 planets. Direct imaging of these planets, as opposed to detection of the effects of orbital motion on their parent star, is now feasible, and the first young planet in a wide orbit may have been detected using adaptive optics systems. Gemini and the VLT are building the first generation of high contrast adaptive optics systems, which deliver planet-imaging performance within few Airy rings of the host star. Thesemore » systems will make the first surveys of the outer regions of solar systems by detecting the self-luminous radiation of young planets. These instruments will establish whether Jovian planets form predominantly through 'top-down' (global gravitational instability) or 'bottom-up' (core accretion) processes. The 8-m 'extreme' AO systems cannot see close enough to the host stars to image Doppler planets, and they cannot reach the relatively distant, young clusters and associations where planets are forming. The Planet Formation Instrument will use the nearly four-fold improved angular resolution of TMT to peer into the inner solar systems of Doppler-planet bearing stars to yield a unified sample of planets with known Keplerian orbital elements and atmospheric properties. In star formation regions, where T Tauri stars (young solar type stars) are found in abundance, PFI can see into the snow line, where the icy cores of planets like Jupiter must have formed. Thus, TMT will be the first facility to witness the formation of new planets.« less

WE-B-210-01: Introduction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holland, M.

In the last fifteen years, the introduction of plane or diverging wave transmissions rather than line by line scanning focused beams has broken the conventional barriers of ultrasound imaging. By using such large field of view transmissions, the frame rate reaches the theoretical limit of physics dictated by the ultrasound speed and an ultrasonic map can be provided typically in tens of micro-seconds (several thousands of frames per second). Interestingly, this leap in frame rate is not only a technological breakthrough but it permits the advent of completely new ultrasound imaging modes, including shear wave elastography, electromechanical wave imaging, ultrafastmore » doppler, ultrafast contrast imaging, and even functional ultrasound imaging of brain activity (fUltrasound) introducing Ultrasound as an emerging full-fledged neuroimaging modality. At ultrafast frame rates, it becomes possible to track in real time the transient vibrations – known as shear waves – propagating through organs. Such “human body seismology” provides quantitative maps of local tissue stiffness whose added value for diagnosis has been recently demonstrated in many fields of radiology (breast, prostate and liver cancer, cardiovascular imaging, …). Today, Supersonic Imagine company is commercializing the first clinical ultrafast ultrasound scanner, Aixplorer with real time Shear Wave Elastography. This is the first example of an ultrafast Ultrasound approach surpassing the research phase and now widely spread in the clinical medical ultrasound community with an installed base of more than 1000 Aixplorer systems in 54 countries worldwide. For blood flow imaging, ultrafast Doppler permits high-precision characterization of complex vascular and cardiac flows. It also gives ultrasound the ability to detect very subtle blood flow in very small vessels. In the brain, such ultrasensitive Doppler paves the way for fUltrasound (functional ultrasound imaging) of brain activity with unprecedented spatial and temporal resolution compared to fMRI. Combined with contrast agents, our group demonstrated that Ultrafast Ultrasound Localization could provide a first in vivo and non invasive imaging modality at microscopic scales deep into organs. Many of these ultrafast modes should lead to major improvements in ultrasound screening, diagnosis, and therapeutic monitoring. Learning Objectives: Achieve familiarity with recent advances in ultrafast ultrasound imaging technology. Develop an understanding of potential applications of ultrafast ultrasound imaging for diagnosis and therapeutic monitoring. Dr. Tanter is a co-founder of Supersonic Imagine,a French company positioned in the field of medical ultrasound imaging and therapy.« less

WE-B-210-00: Carson/Zagzebski Distinguished Lectureship

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

In the last fifteen years, the introduction of plane or diverging wave transmissions rather than line by line scanning focused beams has broken the conventional barriers of ultrasound imaging. By using such large field of view transmissions, the frame rate reaches the theoretical limit of physics dictated by the ultrasound speed and an ultrasonic map can be provided typically in tens of micro-seconds (several thousands of frames per second). Interestingly, this leap in frame rate is not only a technological breakthrough but it permits the advent of completely new ultrasound imaging modes, including shear wave elastography, electromechanical wave imaging, ultrafastmore » doppler, ultrafast contrast imaging, and even functional ultrasound imaging of brain activity (fUltrasound) introducing Ultrasound as an emerging full-fledged neuroimaging modality. At ultrafast frame rates, it becomes possible to track in real time the transient vibrations – known as shear waves – propagating through organs. Such “human body seismology” provides quantitative maps of local tissue stiffness whose added value for diagnosis has been recently demonstrated in many fields of radiology (breast, prostate and liver cancer, cardiovascular imaging, …). Today, Supersonic Imagine company is commercializing the first clinical ultrafast ultrasound scanner, Aixplorer with real time Shear Wave Elastography. This is the first example of an ultrafast Ultrasound approach surpassing the research phase and now widely spread in the clinical medical ultrasound community with an installed base of more than 1000 Aixplorer systems in 54 countries worldwide. For blood flow imaging, ultrafast Doppler permits high-precision characterization of complex vascular and cardiac flows. It also gives ultrasound the ability to detect very subtle blood flow in very small vessels. In the brain, such ultrasensitive Doppler paves the way for fUltrasound (functional ultrasound imaging) of brain activity with unprecedented spatial and temporal resolution compared to fMRI. Combined with contrast agents, our group demonstrated that Ultrafast Ultrasound Localization could provide a first in vivo and non invasive imaging modality at microscopic scales deep into organs. Many of these ultrafast modes should lead to major improvements in ultrasound screening, diagnosis, and therapeutic monitoring. Learning Objectives: Achieve familiarity with recent advances in ultrafast ultrasound imaging technology. Develop an understanding of potential applications of ultrafast ultrasound imaging for diagnosis and therapeutic monitoring. Dr. Tanter is a co-founder of Supersonic Imagine,a French company positioned in the field of medical ultrasound imaging and therapy.« less

WE-B-210-03: Closing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holland, M.

In the last fifteen years, the introduction of plane or diverging wave transmissions rather than line by line scanning focused beams has broken the conventional barriers of ultrasound imaging. By using such large field of view transmissions, the frame rate reaches the theoretical limit of physics dictated by the ultrasound speed and an ultrasonic map can be provided typically in tens of micro-seconds (several thousands of frames per second). Interestingly, this leap in frame rate is not only a technological breakthrough but it permits the advent of completely new ultrasound imaging modes, including shear wave elastography, electromechanical wave imaging, ultrafastmore » doppler, ultrafast contrast imaging, and even functional ultrasound imaging of brain activity (fUltrasound) introducing Ultrasound as an emerging full-fledged neuroimaging modality. At ultrafast frame rates, it becomes possible to track in real time the transient vibrations – known as shear waves – propagating through organs. Such “human body seismology” provides quantitative maps of local tissue stiffness whose added value for diagnosis has been recently demonstrated in many fields of radiology (breast, prostate and liver cancer, cardiovascular imaging, …). Today, Supersonic Imagine company is commercializing the first clinical ultrafast ultrasound scanner, Aixplorer with real time Shear Wave Elastography. This is the first example of an ultrafast Ultrasound approach surpassing the research phase and now widely spread in the clinical medical ultrasound community with an installed base of more than 1000 Aixplorer systems in 54 countries worldwide. For blood flow imaging, ultrafast Doppler permits high-precision characterization of complex vascular and cardiac flows. It also gives ultrasound the ability to detect very subtle blood flow in very small vessels. In the brain, such ultrasensitive Doppler paves the way for fUltrasound (functional ultrasound imaging) of brain activity with unprecedented spatial and temporal resolution compared to fMRI. Combined with contrast agents, our group demonstrated that Ultrafast Ultrasound Localization could provide a first in vivo and non invasive imaging modality at microscopic scales deep into organs. Many of these ultrafast modes should lead to major improvements in ultrasound screening, diagnosis, and therapeutic monitoring. Learning Objectives: Achieve familiarity with recent advances in ultrafast ultrasound imaging technology. Develop an understanding of potential applications of ultrafast ultrasound imaging for diagnosis and therapeutic monitoring. Dr. Tanter is a co-founder of Supersonic Imagine,a French company positioned in the field of medical ultrasound imaging and therapy.« less

Quantitative Doppler Analysis Using Conventional Color Flow Imaging Acquisitions.

PubMed

Karabiyik, Yucel; Ekroll, Ingvild Kinn; Eik-Nes, Sturla H; Lovstakken, Lasse

2018-05-01

Interleaved acquisitions used in conventional triplex mode result in a tradeoff between the frame rate and the quality of velocity estimates. On the other hand, workflow becomes inefficient when the user has to switch between different modes, and measurement variability is increased. This paper investigates the use of power spectral Capon estimator in quantitative Doppler analysis using data acquired with conventional color flow imaging (CFI) schemes. To preserve the number of samples used for velocity estimation, only spatial averaging was utilized, and clutter rejection was performed after spectral estimation. The resulting velocity spectra were evaluated in terms of spectral width using a recently proposed spectral envelope estimator. The spectral envelopes were also used for Doppler index calculations using in vivo and string phantom acquisitions. In vivo results demonstrated that the Capon estimator can provide spectral estimates with sufficient quality for quantitative analysis using packet-based CFI acquisitions. The calculated Doppler indices were similar to the values calculated using spectrograms estimated on a commercial ultrasound scanner.

Eyeballing oscillators for pulsed Doppler radar

NASA Astrophysics Data System (ADS)

Goldman, S.

1985-03-01

The visibility of small targets to a Doppler radar system in the presence of large targets is limited by phase noise. Such limitations occur when an airborne radar searches the ground for a mobile vehicle. Under these conditions, the performance of the Doppler radar depends greatly on the specifications of its phased-locked oscillator. Goldman (1984) has discussed the steps required to evaluate the noise resulting from a pulsed Doppler radar system. In the present investigation, these techniques are applied in reverse to determine system specifications for oscillator noise. A 95-GHz pulsed Doppler radar system is used as an example of specifying system phase noise.

Absolute calibration of Doppler coherence imaging velocity images

NASA Astrophysics Data System (ADS)

Samuell, C. M.; Allen, S. L.; Meyer, W. H.; Howard, J.

2017-08-01

A new technique has been developed for absolutely calibrating a Doppler Coherence Imaging Spectroscopy interferometer for measuring plasma ion and neutral velocities. An optical model of the interferometer is used to generate zero-velocity reference images for the plasma spectral line of interest from a calibration source some spectral distance away. Validation of this technique using a tunable diode laser demonstrated an accuracy better than 0.2 km/s over an extrapolation range of 3.5 nm; a two order of magnitude improvement over linear approaches. While a well-characterized and very stable interferometer is required, this technique opens up the possibility of calibrated velocity measurements in difficult viewing geometries and for complex spectral line-shapes.

Demonstration of new data types for use in interplanetary navigation

NASA Technical Reports Server (NTRS)

Ondrasik, V. J.; Chao, C. C.; Winn, F. B.; Yip, K. B.; Acton, C. H.; Reinbold, S. J.

1974-01-01

Mariner 10 was the first mission which contained many elements of the advanced navigation system which will be used in the late 1970's and 1980's. Preliminary navigation demonstrated were conducted using S/X charged particle calibrations, simultaneous Doppler data, nearly simultaneous range data, and bright object/star imaging data. The results of these demonstrations are very encouraging and a navigation system based upon these data types should be an order of magnitude better than the current system.

Applications of Doppler optical coherence tomography

NASA Astrophysics Data System (ADS)

Xu, Zhiqiang

A major development in biomedical imaging in the last decade has been optical coherence tomography (OCT). This technique enables microscale resolution, depth resolved imaging of the detailed morphology of transparent and nontransparent biological tissue in a noncontact and quasi-noninvasive way. In the first part of this dissertation, we will describe the development and the performance of our home-made OCT systems working with different wavelength regions based on free-space and optical fiber Michelson interferometers. The second part will focus on Doppler OCT (DOCT), an important extension of OCT, which enables the simultaneous evaluation of the structural information and of the fluid flow distribution at a localized position beneath the sample surface. Much effort has been spent during the past few years in our laboratory aimed at providing more accurate velocity measurements with an extended dynamic range. We also applied our technique in different research areas such as microfluidics and hemodynamics. Investigations on the optical properties of the biological tissues (such as absorption and scattering) corresponding to different center wavelengths, have been performed in our laboratory. We used a 10 femtosecond Ti:sapphire laser centered at about 810 nm associated with a free-space Michelson interferometer. The infrared sources were centered at about 1310 and 1560 nm with all-fiber interferometers. Comparative studies using three different sources for several in vitro biological tissues based on a graphical method illustrated how the optical properties affect the quality of the OCT images in terms of the penetration depth and backscattering intensity. We have shown the advantage of working with 810-nm emission wavelength for good backscattering amplitude and contrast, while sources emitting at 1570 nm give good penetration depth. The 1330-nm sources provide a good compromise between the two. Therefore, the choice of the source will ultimately determine the longitudinal resolution and the imaging depth for OCT imaging. Doppler OCT is becoming an increasingly popular field of investigation within optical coherence tomography with potentially important applications in cardiovascular and microfluidic research. We have spent some of the effort on searching for accurate and efficient methods for processing the experimental data. We applied the pseudo Wigner time-frequency distribution method to the data processing of Doppler OCT and compared its performance to that of the short-time Fourier transform method, the Hilbert-based phase-resolved method and the autocorrelation method. We concluded that the pseudo Wigner-distribution signal processing method is overall more precise than other often-used methods in Doppler OCT for the analysis of cross-sectional velocity distributions, especially in the high velocity regime. We also discovered the advantage of using the time-domain instead of the frequency domain for Doppler OCT for some applications where precise Doppler-speed metrology is essential. Based on the fact that the obtained local OCT interference signal is almost a single periodic waveform, we have developed a novel, simple and less time-consuming processing method based on the zero-crossing points in an OCT signal for the measurement of the Doppler frequency in a laminar flow. This method was compared to other processing approaches currently used in Doppler OCT. The results show that in the case of laminar flow, the zero-crossing method gives the more precise results, especially in the higher velocity regime with a substantial economy in processing time and an increase in dynamic range which can reach 70 dB. This feature becomes a major advantage in metrology if one wants to measure velocities over several orders of magnitude. We have applied this technique to some real flow models and the preliminary results on flow velocity distributions obtained in the case of a microfluidic circuit and in that of a phantom of a blood vessel stenosis and bifurcation will be described in this thesis. We also proposed the method to successfully obtain the 2D velocity vector map in the phantom models by overlapping the Doppler OCT scalar velocity distributions of different incident angles. This quantitative knowledge of blood velocity profiles in the vessels can provide very important information in studying some cardiovascular diseases such as atherosclerosis. (Abstract shortened by UMI.)

Analysing simple motions using the Doppler effect—‘seeing’ sound

NASA Astrophysics Data System (ADS)

Stonawski, Tamás; Gálik, Tamás

2017-01-01

The Doppler effect has seen widespread use in the past hundred years. It is used for medical imaging, for measuring speed, temperature, direction, etc, and it makes the spatial relations of motion easy to map. The Doppler effect also allows GPS receivers to measure the speed of a vehicle significantly more accurately than dashboard speedometers. Its diverse applications have prompted us to revisit the simple motions from kinematics with the help of everyday objects in our experiments.

A new Doppler-echo method to quantify regurgitant volume.

PubMed

Wang, S S; Rubenstein, J J; Goldman, M; Sidd, J J

1992-01-01

An in vitro technique using color flow imaging and continuous wave Doppler was developed to measure the initial regurgitant flow jet diameter and velocity integral to yield the parameters for a volume calculation. Jets were produced by volume-controlled injection through tubes of various diameters (1.3, 1.9, 2.8, and 3.5 mm) to deliver volumes from 1 to 7 ml over 100 to 300 msec at pressures from 40 to 200 mm Hg. One hundred forty-five samples were obtained. Flow jet diameter consistently overestimated tube diameter by 2 mm when injected volume was 1.5 to 7 ml and by 1.5 mm when injected volume was less than 1.5 ml. This offset was stable with various transducers (2.5, 3.5, 5.0 MHz) at normal gain setting (just under noise). Therefore, corrected flow jet diameter (FJD) = FJD - 2 mm, and Doppler volume = corrected flow jet area x velocity integral. A range of injectates from 1.1 to 7 ml generated Doppler volume of 1.0 to 8.2 ml. The relation between Doppler volume (DV) and injected volume (IV) was DV = 1.079 IV - 0.22, r2 = 0.945, p less than 0.01. This relation was not altered by tube diameter. Thus a method combining color flow imaging and continuous wave Doppler provides a reliable and accurate measure of in vitro flow volume.

Evaluation of joint effusion in rabbits by color Doppler, power Doppler, and contrast-enhanced power Doppler ultrasonography.

PubMed

Lim, Gye-Yeon; Im, Soo Ah; Jung, Won Sang; Lee, Jae Mun; Lee, Ah Won

2005-09-01

The aim of this prospective study was to evaluate the diagnostic value of power Doppler ultrasonography (PDUS) and contrast-enhanced PDUS (CEPDUS) in the depiction and characterization of experimentally induced arthritis in the rabbit. Thirty rabbits were divided into three groups consisting of one control group (saline injection group) and two experimental groups: a suppurative arthritis group and a chemically induced synovitis group. The same amount (1 ml) of each agent was directly injected into the right hip joint. Serial color Doppler ultrasound (CDUS), PDUS, and CEPDUS images were obtained before and after injection. We observed that all of the infected knees in the suppurative arthritis group with Staphylococcus aureus demonstrated an increased signal on PDUS after inoculation. A minimal power Doppler signal was presented in the chemically induced synovitis group with talc injection, but none of the control knees demonstrated any increased signals. CEPDUS was the most sensitive imaging modality for evaluating the increase of blood flows in suppurative arthritis and was subsequently followed by PDUS and CDUS. The increased signals obtained with PDUS represent increased local blood flows; therefore, this technique can be used for evaluating the degree of inflammation. Furthermore, using the contrast agent enhances the sensitivity of PDUS, and it can even be useful for differentiating borderline cases. Copyright 2005 Wiley Periodicals, Inc

Power Doppler ultrasound of rheumatoid synovitis: quantification of vascular signal and analysis of interobserver variability.

PubMed

Kamishima, Tamotsu; Tanimura, Kazuhide; Henmi, Mihoko; Narita, Akihiro; Sakamoto, Fumihiko; Terae, Satoshi; Shirato, Hiroki

2009-05-01

The objective of this study was to assess interobserver uncertainties in power Doppler (PD) examination of the fingers of patients with rheumatoid arthritis (RA), by separating the source of the discrepancy into (1) acquisition of the images and (2) criteria for assessment of the images. Twenty patients who had been diagnosed with RA were enrolled in this study. Ultrasound examinations were performed by one inexperienced and two experienced sonographers. Interobserver variation was measured using a conventional semiquantitative image grading scale. Interobserver variation of the quantitative PD (QPD) index (the summation of the colored pixels in a region of interest) was also assessed. The agreement was higher between the two experienced sonographers (kappa value of 0.8) than between experienced and inexperienced sonographers (kappa value, 0.6-0.7) in the semiquantitative image grading scale. Results suggest that the difference in the assessment on the image grading scale was due more to the difference in the acquisition of the images than to variations in the grading criteria between sonographers. An excellent relationship was noted between the image grading scale and the QPD index for Doppler signal with a Spearman's coefficient of rank correlation of 0.83 (P < 0.0001). Interobserver discrepancies in the image grading and QPD index methods were due more to the difference in the acquisition of the image than to the grading criteria used. The QPD index seems to be as reliable as the image grading scale with reasonable interobserver agreement between experienced sonographers.

Real-time Transmission and Distribution of NOAA Tail Doppler Radar Data and Other Data Products

NASA Astrophysics Data System (ADS)

Carswell, J.; Chang, P.; Robinson, D.; Gamache, J.; Hill, J.

2011-12-01

The NOAA WP-3D and G-IV aircraft have conducted and continue to conduct numerous research and operational measurement missions. However, typically only a fraction of the data collected aboard each flight is transmitted to the ground in near real-time utilizing low bandwidth satellite data links. The advancements in aircraft satellite phones have increased available bandwidth and reliability to a point where these systems can be utilized for near real-time data flow in support of decision making. A robust and flexible data delivery system has been developed by Remote Sensing Solutions with support from NOAA's National Environmental Satellite, Data and Information Service (NESDIS), Aircraft Operations Center (AOC) and Hurricane Forecast Improvement Project (HFIP). X-band Doppler/reflectivity measurements of tropical storms and cyclones collected from the NOAA WP-3D aircraft have been the most recent focus. Doppler measurements from volume backscatter precipitation profiles can provide critical observations of the horizontal winds as the precipitation advects with these winds. The data delivery system captures these profiles and send the radial Doppler profile observations to National Weather Service in near real-time over satellite communication data link. The design of this transmission system included features to enhance the reliability and robustness of the data flow from the P-3 aircraft to the end user. Routine real-time transmission, using this system, of the full resolution Tail Doppler Radar profile data to the ground and distribution to the NOAA's Hurricane Research Division for analysis and processing in support of initializing the operational HWRF model is planned. The end objective is to provide these Doppler profiles in a routine fashion to NWS and others in the forecasting community for operational utilization in support of hurricane forecasting and warning. Other data sources that are being collected and transmitted to the ground with this system for distribution in near real-time, include but are not limited to, the NOAA Lower Fuselage Radar reflectivity profiles, SFMR retrievals, flight level data, AXBT profiles and Imaging Wind and Rain Airborne Profiler data. The transmission and distribution of these data has a latency of only several seconds from initial acquisition on the aircraft to end users accessing the data through the Internet enabling end users to have a virtual seat on the aircraft and quick dissemination critical observations to the hurricane research, forecasting and modeling communities. In this presentation, the system capabilities and architecture will be described. Examples of the data products and data visualization tools (client applications) will be shown.

Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography.

PubMed

Mor-Avi, Victor; Lang, Roberto M; Badano, Luigi P; Belohlavek, Marek; Cardim, Nuno Miguel; Derumeaux, Genevieve; Galderisi, Maurizio; Marwick, Thomas; Nagueh, Sherif F; Sengupta, Partho P; Sicari, Rosa; Smiseth, Otto A; Smulevitz, Beverly; Takeuchi, Masaaki; Thomas, James D; Vannan, Mani; Voigt, Jens-Uwe; Zamorano, Jose Luis

2011-03-01

Echocardiographic imaging is ideally suited for the evaluation of cardiac mechanics because of its intrinsically dynamic nature. Because for decades, echocardiography has been the only imaging modality that allows dynamic imaging of the heart, it is only natural that new, increasingly automated techniques for sophisticated analysis of cardiac mechanics have been driven by researchers and manufacturers of ultrasound imaging equipment. Several such techniques have emerged over the past decades to address the issue of reader's experience and inter-measurement variability in interpretation. Some were widely embraced by echocardiographers around the world and became part of the clinical routine, whereas others remained limited to research and exploration of new clinical applications. Two such techniques have dominated the research arena of echocardiography: (1) Doppler-based tissue velocity measurements, frequently referred to as tissue Doppler or myocardial Doppler, and (2) speckle tracking on the basis of displacement measurements. Both types of measurements lend themselves to the derivation of multiple parameters of myocardial function. The goal of this document is to focus on the currently available techniques that allow quantitative assessment of myocardial function via image-based analysis of local myocardial dynamics, including Doppler tissue imaging and speckle-tracking echocardiography, as well as integrated back- scatter analysis. This document describes the current and potential clinical applications of these techniques and their strengths and weaknesses, briefly surveys a selection of the relevant published literature while highlighting normal and abnormal findings in the context of different cardiovascular pathologies, and summarizes the unresolved issues, future research priorities, and recommended indications for clinical use.

Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography.

PubMed

Mor-Avi, Victor; Lang, Roberto M; Badano, Luigi P; Belohlavek, Marek; Cardim, Nuno Miguel; Derumeaux, Geneviève; Galderisi, Maurizio; Marwick, Thomas; Nagueh, Sherif F; Sengupta, Partho P; Sicari, Rosa; Smiseth, Otto A; Smulevitz, Beverly; Takeuchi, Masaaki; Thomas, James D; Vannan, Mani; Voigt, Jens-Uwe; Zamorano, José Luis

2011-03-01

Echocardiographic imaging is ideally suited for the evaluation of cardiac mechanics because of its intrinsically dynamic nature. Because for decades, echocardiography has been the only imaging modality that allows dynamic imaging of the heart, it is only natural that new, increasingly automated techniques for sophisticated analysis of cardiac mechanics have been driven by researchers and manufacturers of ultrasound imaging equipment.Several such technique shave emerged over the past decades to address the issue of reader's experience and inter measurement variability in interpretation.Some were widely embraced by echocardiographers around the world and became part of the clinical routine,whereas others remained limited to research and exploration of new clinical applications.Two such techniques have dominated the research arena of echocardiography: (1) Doppler based tissue velocity measurements,frequently referred to as tissue Doppler or myocardial Doppler, and (2) speckle tracking on the basis of displacement measurements.Both types of measurements lend themselves to the derivation of multiple parameters of myocardial function. The goal of this document is to focus on the currently available techniques that allow quantitative assessment of myocardial function via image-based analysis of local myocardial dynamics, including Doppler tissue imaging and speckle-tracking echocardiography, as well as integrated backscatter analysis. This document describes the current and potential clinical applications of these techniques and their strengths and weaknesses,briefly surveys a selection of the relevant published literature while highlighting normal and abnormal findings in the context of different cardiovascular pathologies, and summarizes the unresolved issues, future research priorities, and recommended indications for clinical use.

Vascularization of liver tumors - preliminary results with Coded Harmonic Angio (CHA), phase inversion imaging, 3D power Doppler and contrast medium-enhanced B-flow with second generation contrast agent (Optison).

PubMed

Jung, E M; Kubale, R; Jungius, K-P; Jung, W; Lenhart, M; Clevert, D-A

2006-01-01

To investigate the dynamic value of contrast medium-enhanced ultrasonography with Optison for appraisal of the vascularization of hepatic tumors using harmonic imaging, 3D-/power Doppler and B-flow. 60 patients with a mean age of 56 years (range 35-76 years) with 93 liver tumors, including histopathologically proven hepatocellular carcinoma (HCC) [15 cases with 20 lesions], liver metastases of colorectal tumors [17 cases with 33 lesions], metastases of breast cancer [10 cases with 21 lesions] and hemangiomas [10 cases with 19 lesions] were prospectively investigated by means of multislice CT as well as native and contrast medium-enhanced ultrasound using a multifrequency transducer (2.5-4 MHz, Logig 9, GE). B scan was performed with additional color and power Doppler, followed by a bolus injection of 0.5 ml Optison. Tumor vascularization was evaluated with coded harmonic angio (CHA), pulse inversion imaging with power Doppler, 3D power Doppler and in the late phase (>5 min) with B-flow. In 15 cases with HCC, i.a. DSA was performed in addition. The results were also correlated with MRT and histological findings. Compared to spiral-CT/MRT, only 72/93 (77%) of the lesions could be detected in the B scan, 75/93 (81%) with CHA and 93/93 (100%) in the pulse inversion mode. Tumor vascularization was detectable in 43/93 (46%) of lesions with native power Doppler, in 75/93 (81%) of lesions after administering contrast medium in the CHA mode, in 81/93 (87%) of lesions in the pulse inversion mode with power Doppler and in 77/93 (83%) of lesions with contrast-enhanced B-flow. Early arterial and capillary perfusion was best detected with CHA, particularly in 20/20 (100%) of the HCC lesions, allowing a 3D reconstruction. 3D power Doppler was especially useful in investigating the tumor margins. Up to 20 min after contrast medium injection, B-flow was capable of detecting increased metastatic tumor vascularization in 42/54 (78%) of cases and intratumoral perfusion in 17/20 (85%) of HCC cases. All 19 hemangiomas were correctly classified by phase inversion imaging. Contrast medium-enhanced ultrasound investigation of liver tumors with Optison allowed reliable detection of tumor foci and, in most cases, appraisal of tumor vascularization. The time available for evaluation of tumor margin vascularization was substantially longer in B-flow.

Finnish Meteorological Institute Doppler Lidar

DOE Data Explorer

Ewan OConnor

2015-03-27

This doppler lidar system provides co-polar and cross polar attenuated backscatter coefficients,signal strength, and doppler velocities in the cloud and in the boundary level, including uncertainties for all parameters. Using the doppler beam swinging DBS technique, and Vertical Azimuthal Display (VAD) this system also provides vertical profiles of horizontal winds.

Synovial Inflammation Drives Structural Damage in Hand Osteoarthritis: a Narrative Literature Review.

PubMed

Mancarella, Luana; Addimanda, Olga; Cavallari, Carlotta; Meliconi, Riccardo

2017-01-01

Ultrasound is one of the most promising candidates for the detection of inflammation and structural damage in hand osteoarthritis. To evaluate new advances of US as a diagnostic and prognostic tool in hand osteoarthritis assessment. We conducted a Medline on PubMed search for articles about "ultrasonography" and "hand OA" published between January 2012 and 15th April 2016, limiting our search to articles on human adults in English, excluding those involving systemic inflammatory diseases, visualization of joints other than hands, ultrasound guided injections and surgical procedures. Reviews, case reports, letters, position statements and ex vivo studies were excluded. Concordance between ultrasound and conventional radiography and magnetic resonance imaging was evaluated. Total 46 records were identified, and 16 articles were selected: four showed only ultrasound structural damage (osteophytes, cartilage pathology), six only ultrasound inflammatory variables (synovial thickness, effusion and power Doppler signal), six should considered both ultrasound structural and inflammatory features as well as erosions and two were epidemiological studies. Ultrasound synovitis and power Doppler signal were more frequent in erosive hand osteoarthritis. Followup studies found that ultrasound inflammatory features at baseline are independently associated with radiographic progression; power Doppler signal was the strongest predictor of structural damage. Ultrasound is a reliable tool for cartilage and osteophyte assessment (when performed with static images) and shows a good concordance with magnetic resonance imaging for osteophytes, erosions and synovitis. Ultrasound detected inflammation may predict radiographic progression and may be used in prospective clinical trials of hand osteoarthritis and in everyday clinical practice. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Effect of non-linearity in predicting doppler waveforms through a novel model

PubMed Central

Gayasen, Aman; Dua, Sunil Kumar; Sengupta, Amit; Nagchoudhuri, D

2003-01-01

Background In pregnancy, the uteroplacental vascular system develops de novo locally in utero and a systemic haemodynamic & bio-rheological alteration accompany it. Any abnormality in the non-linear vascular system is believed to trigger the onset of serious morbid conditions like pre-eclampsia and/or intrauterine growth restriction (IUGR). Exact Aetiopathogenesis is unknown. Advancement in the field of non-invasive doppler image analysis and simulation incorporating non-linearities may unfold the complexities associated with the inaccessible uteroplacental vessels. Earlier modeling approaches approximate it as a linear system. Method We proposed a novel electrical model for the uteroplacental system that uses MOSFETs as non-linear elements in place of traditional linear transmission line (TL) model. The model to simulate doppler FVW's was designed by including the inputs from our non-linear mathematical model. While using the MOSFETs as voltage-controlled switches, a fair degree of controlled-non-linearity has been introduced in the model. Comparative analysis was done between the simulated data and the actual doppler FVW's waveforms. Results & Discussion Normal pregnancy has been successfully modeled and the doppler output waveforms are simulated for different gestation time using the model. It is observed that the dicrotic notch disappears and the S/D ratio decreases as the pregnancy matures. Both these results are established clinical facts. Effects of blood density, viscosity and the arterial wall elasticity on the blood flow velocity profile were also studied. Spectral analysis on the output of the model (blood flow velocity) indicated that the Total Harmonic Distortion (THD) falls during the mid-gestation. Conclusion Total harmonic distortion (THD) is found to be informative in determining the Feto-maternal health. Effects of the blood density, the viscosity and the elasticity changes on the blood FVW are simulated. Future works are expected to concentrate mainly on improving the load with respect to varying non-linear parameters in the model. Heart rate variability, which accounts for the vascular tone, should also be included. We also expect the model to initiate extensive clinical or experimental studies in the near future. PMID:14561227

Scanning laser Doppler imaging may predict disease progression of localized scleroderma in children and young adults.

PubMed

Shaw, L J; Shipley, J; Newell, E L; Harris, N; Clinch, J G; Lovell, C R

2013-07-01

Localized scleroderma is a rare but potentially disfiguring and disabling condition. Systemic treatment should be started early in those with active disease in key functional and cosmetic sites, but disease activity is difficult to determine clinically. Superficial blood flow has been shown to correlate with disease activity in localized scleroderma. To examine whether superficial blood flow measured by laser Doppler imaging (LDI) has the potential to predict disease progression and therefore select patients for early systemic treatment. A group of 20 individuals had clinical assessment and scanning LDI blood-flow measurements of 32 affected body sites. After a mean follow-up of 8.7 months their clinical outcome was compared with the results of the initial LDI assessment. Eleven out of 15 patients with an assessment of active LDI had progressed clinically, and 16 out of the 17 scans with inactive LDI assessment had not progressed, giving a positive predictive value of 73% and a negative predictive value of 94%. We believe that LDI can be a useful tool in predicting disease progression in localized scleroderma, and it may help clinicians to decide which patients to treat early. © 2013 The Authors BJD © 2013 British Association of Dermatologists.

Design and Ground Calibration of the Helioseismic and Magnetic Imager (HMI) Instrument on the Solar Dynamics Observatory (SDO)

NASA Technical Reports Server (NTRS)

Schou, J.; Scherrer, P. H.; Bush, R. I.; Wachter, R.; Couvidat, S.; Rabello-Soares, M. C.; Bogart, R. S.; Hoeksema, J. T.; Liu, Y.; Duvall, T. L., Jr.;

Real time display Fourier-domain OCT using multi-thread parallel computing with data vectorization

NASA Astrophysics Data System (ADS)

Eom, Tae Joong; Kim, Hoon Seop; Kim, Chul Min; Lee, Yeung Lak; Choi, Eun-Seo

2011-03-01

We demonstrate a real-time display of processed OCT images using multi-thread parallel computing with a quad-core CPU of a personal computer. The data of each A-line are treated as one vector to maximize the data translation rate between the cores of the CPU and RAM stored image data. A display rate of 29.9 frames/sec for processed OCT data (4096 FFT-size x 500 A-scans) is achieved in our system using a wavelength swept source with 52-kHz swept frequency. The data processing times of the OCT image and a Doppler OCT image with a 4-time average are 23.8 msec and 91.4 msec.

Logic design and implementation of FPGA for a high frame rate ultrasound imaging system

NASA Astrophysics Data System (ADS)

Liu, Anjun; Wang, Jing; Lu, Jian-Yu

2002-05-01

Recently, a method has been developed for high frame rate medical imaging [Jian-yu Lu, ``2D and 3D high frame rate imaging with limited diffraction beams,'' IEEE Trans. Ultrason. Ferroelectr. Freq. Control 44(4), 839-856 (1997)]. To realize this method, a complicated system [multiple-channel simultaneous data acquisition, large memory in each channel for storing up to 16 seconds of data at 40 MHz and 12-bit resolution, time-variable-gain (TGC) control, Doppler imaging, harmonic imaging, as well as coded transmissions] is designed. Due to the complexity of the system, field programmable gate array (FPGA) (Xilinx Spartn II) is used. In this presentation, the design and implementation of the FPGA for the system will be reported. This includes the synchronous dynamic random access memory (SDRAM) controller and other system controllers, time sharing for auto-refresh of SDRAMs to reduce peak power, transmission and imaging modality selections, ECG data acquisition and synchronization, 160 MHz delay locked loop (DLL) for accurate timing, and data transfer via either a parallel port or a PCI bus for post image processing. [Work supported in part by Grant 5RO1 HL60301 from NIH.

Comparative analysis of renal flow using contrast power Doppler and gray-scale ultrasound

NASA Astrophysics Data System (ADS)

Sehgal, Chandra M.; Arger, Peter H.; Bovee, Kenneth C.; Pugh, Charles; Kirchhofer, Justin I.

1997-05-01

Our previous studies have shown that renal perfusion can be visualized by imaging the transit of a contrast agent through the parenchyma of the organ using gray scale (GS) and power Doppler (PD) ultrasound.However, the relative merits and the sensitivities of the two imaging methods are not known. This study compares the effectiveness of the two modes in visualizing kidney perfusion at the clinical dose of contrast agents. GS and PD images of the dog kidneys were recorded using a clinical ultrasound scanner at 4-7 MHz. A fixed longitudinal plane of the kidney was imaged by mounting the transducer on the animal with a specially designed holder. A dose of 0.1 m1/kg of Echogen was injected intravenously and GS and PD images were recorded simultaneously on two separate time-encoded video tapes during the passage of the contrast agent through the kidneys. The enhancement of GS and PD images was assessed qualitatively by three radiologists. The quantitative assessment was made by measuring the regional and global enhancements of digitized B-scan and PS images. Regional measurements were made by comparing brightness of the post contrast images with that of a pre-contrast reference image pixel by pixel. Student t-test was used to determine the statistical significance of the change. The regions representing statistically significant differences were encoded on the image in color with brightness proportional to the magnitude of change. The regions with no significant change were represented in GS. This generated a series of new images, referred to as StatMap, with color representing regions of perfusion. Changes in power Doppler images were visually detectable with high confidence in all five dogs by al three radiologists. There was no perceptible changes in B-scans. Computer analysis of PD images yielded characteristic indicator dilution curves in all five dogs with an initial rise time of 2-5 sec and a peak at 7-20 sec. The enhancement in PD lasted for 97-400 seconds. The peak to pre-injection Doppler power ratio was 2.41 +/- 0.85. There were not detectable changes in gray scale images except in one dog which exhibited a small change. The StatMap images of PD exhibited perfusion over the entire kidney, whereas the GS images showed perfusion to be sparsely distributed.

Multibeam single frequency synthetic aperture radar processor for imaging separate range swaths

NASA Technical Reports Server (NTRS)

Jain, A. (Inventor)

1982-01-01

A single-frequency multibeam synthetic aperture radar for large swath imaging is disclosed. Each beam illuminates a separate ""footprint'' (i.e., range and azimuth interval). The distinct azimuth intervals for the separate beams produce a distinct Doppler frequency spectrum for each beam. After range correlation of raw data, an optical processor develops image data for the different beams by spatially separating the beams to place each beam of different Doppler frequency spectrum in a different location in the frequency plane as well as the imaging plane of the optical processor. Selection of a beam for imaging may be made in the frequency plane by adjusting the position of an aperture, or in the image plane by adjusting the position of a slit. The raw data may also be processed in digital form in an analogous manner.

SAR imaging - Seeing the unseen

NASA Technical Reports Server (NTRS)

Kobrick, M.

1982-01-01

The functional abilities and operations of synthetic aperture radar (SAR) are described. SAR employs long wavelength radio waves in bursts, imaging a target by 'listening' to the small frequency changes that result from the Doppler shift due to the relative motion of the imaging craft and the motions of the target. The time delay of the signal return allows a determination of the location of the target, leading to the build up of a two-dimensional image. The uses of both Doppler shifts and time delay enable detailed imagery which is independent of distance. The synthetic aperture part of the name of SAR derives from the beaming of multiple pulses, which result in a picture that is effectively the same as using a large antenna. Mechanisms contributing to the fineness of SAR images are outlined.

A System-on-Chip Solution for Point-of-Care Ultrasound Imaging Systems: Architecture and ASIC Implementation.

PubMed

Kang, Jeeun; Yoon, Changhan; Lee, Jaejin; Kye, Sang-Bum; Lee, Yongbae; Chang, Jin Ho; Kim, Gi-Duck; Yoo, Yangmo; Song, Tai-kyong

2016-04-01

In this paper, we present a novel system-on-chip (SOC) solution for a portable ultrasound imaging system (PUS) for point-of-care applications. The PUS-SOC includes all of the signal processing modules (i.e., the transmit and dynamic receive beamformer modules, mid- and back-end processors, and color Doppler processors) as well as an efficient architecture for hardware-based imaging methods (e.g., dynamic delay calculation, multi-beamforming, and coded excitation and compression). The PUS-SOC was fabricated using a UMC 130-nm NAND process and has 16.8 GFLOPS of computing power with a total equivalent gate count of 12.1 million, which is comparable to a Pentium-4 CPU. The size and power consumption of the PUS-SOC are 27×27 mm(2) and 1.2 W, respectively. Based on the PUS-SOC, a prototype hand-held US imaging system was implemented. Phantom experiments demonstrated that the PUS-SOC can provide appropriate image quality for point-of-care applications with a compact PDA size ( 200×120×45 mm(3)) and 3 hours of battery life.

Left ventricular to left atrial communication secondary to a paraaortic abscess: color flow Doppler documentation.

PubMed

Fisher, E A; Estioko, M R; Stern, E H; Goldman, M E

1987-07-01

Aortic root abscess occurs frequently in aortic prosthetic valve infective endocarditis. The present echocardiographic report documents a ruptured abscess that led to a direct communication between the left ventricular outflow tract and the left atrium confirmed by real-time (color flow) Doppler imaging.

Measuring hemodynamics in the developing heart tube with four-dimensional gated Doppler optical coherence tomography

NASA Astrophysics Data System (ADS)

Jenkins, Michael W.; Peterson, Lindsy; Gu, Shi; Gargesha, Madhusudhana; Wilson, David L.; Watanabe, Michiko; Rollins, Andrew M.

2010-11-01

Hemodynamics is thought to play a major role in heart development, yet tools to quantitatively assess hemodynamics in the embryo are sorely lacking. The especially challenging analysis of hemodynamics in the early embryo requires new technology. Small changes in blood flow could indicate when anomalies are initiated even before structural changes can be detected. Furthermore, small changes in the early embryo that affect blood flow could lead to profound abnormalities at later stages. We present a demonstration of 4-D Doppler optical coherence tomography (OCT) imaging of structure and flow, and present several new hemodynamic measurements on embryonic avian hearts at early stages prior to the formation of the four chambers. Using 4-D data, pulsed Doppler measurements could accurately be attained in the inflow and outflow of the heart tube. Also, by employing an en-face slice from the 4-D Doppler image set, measurements of stroke volume and cardiac output are obtained without the need to determine absolute velocity. Finally, an image plane orthogonal to the blood flow is used to determine shear stress by calculating the velocity gradient normal to the endocardium. Hemodynamic measurements will be crucial to identifying genetic and environmental factors that lead to congenital heart defects.

SDOCT Doppler velocimetry for investigating the morphological influences on blood flow in the developing chick embryo heart

NASA Astrophysics Data System (ADS)

Davis, Anjul M.; Rothenberg, Florence G.; Law, Tzuo H.; Taber, Larry A.; Izatt, Joseph A.

2007-02-01

The onset of congenital heart disease (CHD) is believed to occur at very early stages of development. Investigations in the initiation and development of CHD has been hampered by the inability to image early stage heart structure and function, in vivo. Imaging small animals using optical coherence tomography (OCT) has filled a niche between the limited penetration depth of confocal microscopy and insufficient resolution from ultrasound. Previous demonstrations of chick heart imaging using OCT have entailed excision of, or arresting the heart to prevent motion artifacts. In this summary, we introduce SDOCT Doppler velocimetry as an enhancement of Doppler OCT for in vivo measurement of localized temporal blood flow dynamics. With this technique, dynamic velocity waveforms were measured in the outflow tract of the heart tube. These flow dynamics correlate to a finite element model of pulsatile flow and may lead to a further understanding of morphological influences on early heart development.

Quantitative imaging of red blood cell velocity invivo using optical coherence Doppler tomography

NASA Astrophysics Data System (ADS)

Ren, Hugang; Du, Congwu; Park, Kicheon; Volkow, Nora D.; Pan, Yingtian

2012-06-01

We present particle counting ultrahigh-resolution optical Doppler tomography (pc-μODT) that enables accurate imaging of red blood cell velocities (νRBC) of cerebrovascular networks by detecting the Doppler phase transients induced by the passage of a RBC through a capillary. We apply pc-μODT to image the response of capillary νRBC to mild hypercapnia in mouse cortex. The results show that νRBC in normocapnia (νN = 0.72 ± 0.15 mm/s) increased 36.1% ± 5.3% (νH = 0.98 ± 0.29 mm/s) in response to hypercapnia. Due to uncorrected angle effect and low hematocrit (e.g., ˜10%), νRBC directly measured by μODT were markedly underestimated (νN ≈ 0.27 ± 0.03 mm/s, νH ≈ 0.37± 0.05 mm/s). Nevertheless, the measured νRBC increase (35.3%) matched that (36.1% ± 5.3%) by pc-μODT.

Western Pacific Tropical Cyclone Adaptive Observing of Inner Core Life-cycle Structure and Intensity Change

DTIC Science & Technology

2009-09-30

airborne radar images; develop an analysis scheme for the monsoon and storm- scale circulation features that would: a. Define large-scale context...Doppler radar observations of TC mesoscale observations. The TCS-08 field program provided unique aircraft reconnaissance (recon) data that will be...system for WC-130J, as well as developed new system for recording airborne radar video for the first time. 3. Created an archive of all WC-130J

Speckle tracking analysis: a new tool for left atrial function analysis in systemic hypertension: an overview.

PubMed

Cameli, Matteo; Ciccone, Marco M; Maiello, Maria; Modesti, Pietro A; Muiesan, Maria L; Scicchitano, Pietro; Novo, Salvatore; Palmiero, Pasquale; Saba, Pier S; Pedrinelli, Roberto

2016-05-01

Speckle tracking echocardiography (STE) is an imaging technique applied to the analysis of left atrial function. STE provides a non-Doppler, angle-independent and objective quantification of left atrial myocardial deformation. Data regarding feasibility, accuracy and clinical applications of left atrial strain are rapidly gathering. This review describes the fundamental concepts of left atrial STE, illustrates its pathophysiological background and discusses its emerging role in systemic arterial hypertension.

Enhanced spectral domain optical coherence tomography for pathological and functional studies

NASA Astrophysics Data System (ADS)

Yuan, Zhijia

Optical coherence tomography (OCT) is a novel technique that enables noninvasive or minimally invasive, cross-sectional imaging of biological tissue at sub-10mum spatial resolution and up to 2-3mm imaging depth. Numerous technological advances have emerged in recent years that have shown great potential to develop OCT into a powerful imaging and diagnostic tools. In particular, the implementation of Fourier-domain OCT (FDOCT) is a major step forward that leads to greatly improved imaging rate and image fidelity of OCT. This dissertation summarizes the work that focuses on enhancing the performances and functionalities of spectral radar based FDOCT (SDOCT) for pathological and functional applications. More specifically, chapters 1-4 emphasize on the development of SDOCT and its utility in pathological studies, including cancer diagnosis. The principle of SDOCT is first briefly outlined, followed by the design of our bench-top SDOCT systems with emphasis on spectral linear interpolation, calibration and system dispersion compensation. For ultrahigh-resolution SDOCT, time-lapse image registration and frame averaging is introduced to effectively reduce speckle noise and uncover subcellular details, showing great promise for enhancing the diagnosis of carcinoma in situ. To overcome the image depth limitation of OCT, a dual-modal imaging method combing SDOCT with high-frequency ultrasound is proposed and examined in animal cancer models to enhance the sensitivity and staging capabilities for bladder cancer diagnosis. Chapters 5-7 summarize the work on developing Doppler SDOCT for functional studies. Digital-frequency-ramping OCT (DFR-OCT) is developed in the study, which has demonstrated the ability to significantly improve the signal-to-noise ratio and thus sensitivity for retrieving subsurface blood flow imaging. New DFR algorithms and imaging processing methods are discussed to further enhance cortical CBF imaging. Applications of DFR-OCT for brain functional studies are presented and laser speckle imaging is combined to enable quantitative cerebral blood flow (CBF) imaging at high spatiotemporal resolutions. An angiography-enhanced Doppler optical coherence tomography (aDFR-OCT) was also demonstrated to enable quantitative imaging of capillary changes for brain functional studies. Lastly, future work on technological development and potential biomedical applications is briefly outlined.

Left ventricular longitudinal myocardial function in overt hypothyroidism: a tissue Doppler echocardiographic study.

PubMed

Tiryakioglu, Selma Kenar; Tiryakioglu, Osman; Ari, Hasan; Basel, Mehmet Cem; Ozkan, Hakan; Bozat, Tahsin

2010-05-01

The aim of this study was to assess left ventricular (LV) myocardial regional function in overt hypothyroidism by use of tissue Doppler imaging and to compare the results to the hormonal profile and standard Doppler echocardiographic examination. Hypothyroidic (Group 1, n = 25) and euthyroidic patients (Group 2, n = 25) underwent transthorasic echocardiography, strain and strain rate imaging. Standard echocardiography showed that patients with overt hypothyroidism had significantly longer isovolumic contraction time (IVCT) (P < 0.05), deceleration time (DT) (P = 0.014) and isovolumic relaxation time (IVRT) (P = 0.022). Tissue Doppler imaging showed that the mean peak systolic strain (SI) (16.47 + or - 1.45 vs. 20.63 + or - 1.51, P < 0.001), the mean peak systolic strain rate (SSR) (1.05 + or - 0.13 vs. 1.47 + or - 0.11, P < 0.001), the mean peak early diastolic strain rate (ESr) (1.72 + or - 0.38 vs. 2.03 + or - 0.25, P < 0.05) and the mean peak late diastolic strain rate (ASr) (1.22 + or - 0.31 vs. 1.46 + or - 0.32, P < 0.05) were significantly lower in Group 1 compared to Group 2. For all patients, the systolic strain and systolic strain rate parameters negatively correlated with thyroid stimulating hormone levels and positively correlated with the levels of free triiodothyronine (fT(3)) and free tetraiodothyronine (fT(4)). These results indicate that overt hypothyroidism is associated with early impairment in LV longitudinal myocardial function, and that tissue Doppler echocardiography is useful for the grading of disease and detection of early impairment. (ECHOCARDIOGRAPHY 2010;27:505-511).

Advantages and limits of hemorrhoidal dearterialization in the treatment of symptomatic hemorrhoids

PubMed Central

Giamundo, Paolo

2016-01-01

In the last two decades, hemorrhoidal dearterialization has become universally accepted as a treatment option for symptomatic hemorrhoids. The rationale for this procedure is based on the assumption that arterial blood overflow is mainly responsible for dilatation of the hemorrhoidal plexus due to the absence of capillary interposition between the arterial and venous systems within the anal canal. Dearterialization, with either suture ligation (Doppler-guided hemorrhoid artery ligation/transanal hemorrhoidal dearterialization) or laser (hemorrhoidal laser procedure), may be successfully performed alone or with mucopexy. Although the added value of Doppler-guidance in association with dearterialization has recently been challenged, this imaging method still plays an important role in localizing hemorrhoidal arteries and, therefore, minimizing the effect of anatomic variation among patients. However, it is important to employ the correct Doppler transducer. Some Doppler transducers may not easily detect superficial arteries due to inadequate frequency settings. All techniques of dearterialization have the advantage of preserving the anatomy and physiology of the anal canal, when compared to other surgical treatments for hemorrhoids. This advantage cannot be underestimated as impaired anal function, including fecal incontinence and other defecation disorders, may occur following surgical treatment for hemorrhoids. Furthermore, this potentially devastating problem can occur in patients of all ages, including younger patients. PMID:26843909

Advantages and limits of hemorrhoidal dearterialization in the treatment of symptomatic hemorrhoids.

PubMed

Giamundo, Paolo

2016-01-27

In the last two decades, hemorrhoidal dearterialization has become universally accepted as a treatment option for symptomatic hemorrhoids. The rationale for this procedure is based on the assumption that arterial blood overflow is mainly responsible for dilatation of the hemorrhoidal plexus due to the absence of capillary interposition between the arterial and venous systems within the anal canal. Dearterialization, with either suture ligation (Doppler-guided hemorrhoid artery ligation/transanal hemorrhoidal dearterialization) or laser (hemorrhoidal laser procedure), may be successfully performed alone or with mucopexy. Although the added value of Doppler-guidance in association with dearterialization has recently been challenged, this imaging method still plays an important role in localizing hemorrhoidal arteries and, therefore, minimizing the effect of anatomic variation among patients. However, it is important to employ the correct Doppler transducer. Some Doppler transducers may not easily detect superficial arteries due to inadequate frequency settings. All techniques of dearterialization have the advantage of preserving the anatomy and physiology of the anal canal, when compared to other surgical treatments for hemorrhoids. This advantage cannot be underestimated as impaired anal function, including fecal incontinence and other defecation disorders, may occur following surgical treatment for hemorrhoids. Furthermore, this potentially devastating problem can occur in patients of all ages, including younger patients.

Transcranial power M-mode Doppler ultrasound for diagnosis of patent foramen ovale

NASA Astrophysics Data System (ADS)

Moehring, Mark; Spencer, Merrill

2005-04-01

Patent foramen ovale (PFO) is a right-to-left shunt (RLS) which communicates blood from the right to left atrium of the heart. PFO has been associated with stroke and, more recently, with migraine headache. Diagnosis of RLS can be accomplished effectively with transcranial power M-mode Doppler ultrasound (PMD). PMD is a modality which can be performed without the sedation required by the more invasive diagnostic technique using transesophageal echocardiography. PMD for this application consists of 2 MHz pulse Doppler ultrasound with placement of sample gates at 2 mm intervals along the single-transducer beam axis, and 8 kHz pulse repetition rate (PMD100M, Spencer Technologies). Doppler power versus depth is constructed every 4ms, using 33 sample gates. Bubble microemboli injected in the venous system and moving across a PFO present as high intensity tracks on a PMD image, as emboli transit from the heart to the brain and through the observed cerebral vasculature. Use of PMD in this context has been reported in the clinical literature [M. P. Spencer, M. A. Moehring, J. Jesurum et al, J. Neuroimaging 14, 342-349 (2004)]. This talk surveys the basic technical features of PMD for sensing PFO-related showers of bubble microemboli, and how these features provide clues to the severity of PFO.

Grey-scale and colour Doppler ultrasound versus magnetic resonance imaging for the prenatal diagnosis of placenta accreta.

PubMed

Rezk, Mohamed Abd-Allah; Shawky, Mohamed

2016-01-01

To assess the effectiveness of grey-scale and colour Doppler ultrasound (US) versus magnetic resonance imaging (MRI) for the prenatal diagnosis of placenta accreta. A prospective observational study including a total of 74 patients with placenta previa and previous uterine scar (n = 74). Grey-scale and colour Doppler US was done followed by MRI by different observers to diagnose adherent placenta. Test validity of US and MRI were calculated. Maternal morbidity and mortality were also assessed. A total of 53 patients confirmed to have placenta accreta at operation. The overall sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of US was 94.34, 91.67, 96.15 and 88% compared to 96.08, 87.50, 94.23 and 91.3% for MRI, respectively. The most relevant US sign was turbulent blood flow by colour Doppler, while dark intra-placental band was the most sensitive MRI sign. Venous thromboembolism (1.3%), bladder injury (29.7%), ureteric injury (18.9%), postoperative fever (10.8%), admission to ICU (50%) and re-operation (31.1%). Placenta accreta can be successfully diagnosed by grey-scale and colour Doppler US. MRI would be more likely suggested for either posteriorly or laterally situated placenta previa in order to exclude placental invasion.

Radar Imaging of Asteroids

NASA Astrophysics Data System (ADS)

Ostro, S. J.

1996-09-01

Measurements of the distribution of echo power in time delay (range) and Doppler frequency (line-of-sight velocity) can synthesize images of near-Earth and main-belt asteroids (NEAs and MBAs) that traverse the detectability windows of groundbased radar telescopes. Under ideal circumstances, current radar waveforms can achieve decameter surface resolution. The number of useful pixels obtainable in an imaging data set is of the same order as the signal-to-noise ratio, SNR, of an optimally filtered, weighted sum of all the data. (SNR increases as the square root of the integration time.) The upgraded Arecibo telescope which is about to become operational, should be able to achieve single-date SNRs {\\underline>} (20,100) for an average of (35,5) MBAs per year and single-date SNRs {\\underline>} (20,100,1000) for an average of (10,6,2) of the currently catalogued NEAs per year; optical surveying of the NEA population could increase the frequency of opportunities by an order of magnitude. The strongest imaging opportunities predicted for Arecibo between now and the end of 1997 include (the peak SNR/date is in parentheses): 9 Metis (110), 27 Euterpe (170), 80 Sappho (100), 139 Juewa (140), 144 Vibilia (140), 253 Mathilde (100), 2102 Tantalus (570), 3671 Dionysus (170), 3908 1980PA (4400), 4179 Toutatis (16000), 4197 1982TA (1200), 1991VK (700), and 1994PC1 (7400). A delay-Doppler image projects the echo power distribution onto the target's apparent equatorial plane. One cannot know a priori whether one or two (or more) points on the asteroid contributed power to a given pixel, so accurate interpretation of delay-Doppler images requires modeling (Hudson, 1993, Remote Sensing Rev. 8, 195-203). Inversion of an imaging sequence with enough orientational coverage can remove "north/south" ambiguities and can provide estimates of the target's three-dimensional shape, spin state, radar scattering properties, and delay-Doppler trajectory (e.g., Ostro et al. 1995, Science 270, 80-83; Hudson and Ostro 1995, Science 270, 84-86).

Power and color Doppler ultrasound settings for inflammatory flow: impact on scoring of disease activity in patients with rheumatoid arthritis.

PubMed

Torp-Pedersen, Søren; Christensen, Robin; Szkudlarek, Marcin; Ellegaard, Karen; D'Agostino, Maria Antonietta; Iagnocco, Annamaria; Naredo, Esperanza; Balint, Peter; Wakefield, Richard J; Torp-Pedersen, Arendse; Terslev, Lene

2015-02-01

To determine how settings for power and color Doppler ultrasound sensitivity vary on different high- and intermediate-range ultrasound machines and to evaluate the impact of these changes on Doppler scoring of inflamed joints. Six different types of ultrasound machines were used. On each machine, the factory setting for superficial musculoskeletal scanning was used unchanged for both color and power Doppler modalities. The settings were then adjusted for increased Doppler sensitivity, and these settings were designated study settings. Eleven patients with rheumatoid arthritis (RA) with wrist involvement were scanned on the 6 machines, each with 4 settings, generating 264 Doppler images for scoring and color quantification. Doppler sensitivity was measured with a quantitative assessment of Doppler activity: color fraction. Higher color fraction indicated higher sensitivity. Power Doppler was more sensitive on half of the machines, whereas color Doppler was more sensitive on the other half, using both factory settings and study settings. There was an average increase in Doppler sensitivity, despite modality, of 78% when study settings were applied. Over the 6 machines, 2 Doppler modalities, and 2 settings, the grades for each of 7 of the patients varied between 0 and 3, while the grades for each of the other 4 patients varied between 0 and 2. The effect of using different machines, Doppler modalities, and settings has a considerable influence on the quantification of inflammation by ultrasound in RA patients, and this must be taken into account in multicenter studies. Copyright © 2015 by the American College of Rheumatology.

Language Lateralization in Children Using Functional Transcranial Doppler Sonography

ERIC Educational Resources Information Center

Haag, Anja; Moeller, Nicola; Knake, Susanne; Hermsen, Anke; Oertel, Wolfgang H.; Rosenow, Felix; Hamer, Hajo M.

2010-01-01

Aim: Language lateralization with functional transcranial Doppler sonography (fTCD) and lexical word generation has been shown to have high concordance with the Wada test and functional magnetic resonance imaging in adults. We evaluated a nonlexical paradigm to determine language dominance in children. Method: In 23 right-handed children (12…

Propofol Induction's Effect on Cardiac Function

ClinicalTrials.gov

2015-03-31

This Study Was Focused to Evaluate Feasibility of Doppler Tissue Monitoring During the Induction Anesthesia,; and Evaluate Routine Propofol Induction's Effect on Myocardial Tissue Motion, Using Non-invasive Doppler Tissue and 2D Speckle Tracking Imaging.; This is the First Study, to Our Knowledge, Which Has Evaluated the Possible Impact of Propofol Induction on LV Function.

WE-B-210-02: The Advent of Ultrafast Imaging in Biomedical Ultrasound

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tanter, M.

In the last fifteen years, the introduction of plane or diverging wave transmissions rather than line by line scanning focused beams has broken the conventional barriers of ultrasound imaging. By using such large field of view transmissions, the frame rate reaches the theoretical limit of physics dictated by the ultrasound speed and an ultrasonic map can be provided typically in tens of micro-seconds (several thousands of frames per second). Interestingly, this leap in frame rate is not only a technological breakthrough but it permits the advent of completely new ultrasound imaging modes, including shear wave elastography, electromechanical wave imaging, ultrafastmore » doppler, ultrafast contrast imaging, and even functional ultrasound imaging of brain activity (fUltrasound) introducing Ultrasound as an emerging full-fledged neuroimaging modality. At ultrafast frame rates, it becomes possible to track in real time the transient vibrations – known as shear waves – propagating through organs. Such “human body seismology” provides quantitative maps of local tissue stiffness whose added value for diagnosis has been recently demonstrated in many fields of radiology (breast, prostate and liver cancer, cardiovascular imaging, …). Today, Supersonic Imagine company is commercializing the first clinical ultrafast ultrasound scanner, Aixplorer with real time Shear Wave Elastography. This is the first example of an ultrafast Ultrasound approach surpassing the research phase and now widely spread in the clinical medical ultrasound community with an installed base of more than 1000 Aixplorer systems in 54 countries worldwide. For blood flow imaging, ultrafast Doppler permits high-precision characterization of complex vascular and cardiac flows. It also gives ultrasound the ability to detect very subtle blood flow in very small vessels. In the brain, such ultrasensitive Doppler paves the way for fUltrasound (functional ultrasound imaging) of brain activity with unprecedented spatial and temporal resolution compared to fMRI. Combined with contrast agents, our group demonstrated that Ultrafast Ultrasound Localization could provide a first in vivo and non invasive imaging modality at microscopic scales deep into organs. Many of these ultrafast modes should lead to major improvements in ultrasound screening, diagnosis, and therapeutic monitoring. Learning Objectives: Achieve familiarity with recent advances in ultrafast ultrasound imaging technology. Develop an understanding of potential applications of ultrafast ultrasound imaging for diagnosis and therapeutic monitoring. Dr. Tanter is a co-founder of Supersonic Imagine,a French company positioned in the field of medical ultrasound imaging and therapy.« less

Analysis of Supergranule Sizes and Velocities Using Solar Dynamics Observatory (SDO)/Helioseismic Magnetic Imager (HMI) and Solar and Heliospheric Observatory (SOHO)/Michelson Doppler Imager (MDI) Dopplergrams

NASA Technical Reports Server (NTRS)

Williams, Peter E.; Pesnell, W. Dean; Beck, John G.; Lee, Shannon

2013-01-01

Co-temporal Doppler images from Solar and Heliospheric Observatory (SOHO)/ Michelson Doppler Imager (MDI) and Solar Dynamics Observatory (SDO)/Helioseismic Magnetic Imager (HMI) have been analyzed to extract quantitative information about global properties of the spatial and temporal characteristics of solar supergranulation. Preliminary comparisons show that supergranules appear to be smaller and have stronger horizontal velocity flows within HMI data than was measured with MDI. There appears to be no difference in their evolutionary timescales. Supergranule sizes and velocities were analyzed over a ten-day time period at a 15-minute cadence. While the averages of the time-series retain the aforementioned differences, fluctuations of these parameters first observed in MDI data were seen in both MDI and HMI time-series, exhibiting a strong cross-correlation. This verifies that these fluctuations are not instrumental, but are solar in origin. The observed discrepancies between the averaged values from the two sets of data are a consequence of instrument resolution. The lower spatial resolution of MDI results in larger observed structures with lower velocities than is seen in HMI. While these results offer a further constraint on the physical nature of supergranules, they also provide a level of calibration between the two instruments.

Predictors of transient left ventricular dysfunction following transcatheter patent ductus arteriosus closure in pediatric age.

PubMed

Agha, Hala Mounir; Hamza, Hala S; Kotby, Alyaa; Ganzoury, Mona E L; Soliman, Nanies

2017-10-01

To evaluate the left ventricular function before and after transcatheter percutaneous patent ductus arteriosus (PDA) closure, and to identify the predictors of myocardial dysfunction post-PDA closure if present. Transcatheter PDA closure; conventional, Doppler, and tissue Doppler imaging; and speckle tracking echocardiography. To determine the feasibility and reliability of tissue Doppler and myocardial deformation imaging for evaluating myocardial function in children undergoing transcatheter PDA closure. Forty-two children diagnosed with hemodynamically significant PDA underwent percutaneous PDA closure. Conventional, Doppler, and tissue Doppler imaging, and speckle-derived strain rate echocardiography were performed at preclosure and at 48 hours, 1 month, and 6 months postclosure. Tissue Doppler velocities of the lateral and septal mitral valve annuli were obtained. Global and regional longitudinal peak systolic strain values were determined using two-dimensional speckle tracking echocardiography. The median age of the patients was 2 years and body weight was 15 kg, with the mean PDA diameter of 3.11 ± 0.99 mm. M-mode measurements (left ventricular end diastolic diameter, left atrium diameter to aortic annulus ratio, ejection fraction, and shortening fraction) reduced significantly early after PDA closure ( p  < 0.001). After 1 month, left ventricular end diastolic diameter and left atrium diameter to aortic annulus ratio continued to decrease, while ejection fraction and fractional shortening improved significantly. All tissue Doppler velocities showed a significant decrease at 48 hours with significant prolongation of global myocardial function ( p  < 0.001) and then were normalized within 1 month postclosure. Similarly, global longitudinal strain significantly decreased at 48 hours postclosure ( p  < 0.001), which also recovered at 1 month follow-up. Preclosure global longitudinal strain showed a good correlation with the postclosure prolongation of the myocardial performance index. Transcatheter PDA closure causes a significant decrease in left ventricular performance early after PDA closure, which recovers completely within 1 month. Preclosure global longitudinal strain can be a predictor of postclosure myocardial dysfunction.

Remote sensing of mesospheric winds with the High-Resolution Doppler Imager

NASA Technical Reports Server (NTRS)

Hays, Paul B.; Abreu, V. J.; Burrage, M. D.; Gell, D. A.; Grassi, H. J.; Marshall, A. R.; Morton, Y. T.; Ortland, D. A.; Skinner, W. R.; Wu, D. L.

1992-01-01

Observations of the winds in the upper atmosphere obtained with the High-Resolution Doppler Imager (HRDI) on the Upper Atmosphere Research Satellite (UARS) are discussed. This instrument is a very stable high-resolution triple-etalon Fabry-Perot interferometer, which is used to observe the slight Doppler shifts of absorption and emission lines in the O2 Atmospheric bands induced by atmospheric motions. Preliminary observations indicate that the winds in the mesosphere and lower thermosphere are a mixture of migrating and non-migrating tides, and planetary-scale waves. The mean meridional winds are dominated by the 1,1 diurnal tide which is easily extracted from the daily zonal means of the satellite observations. The daily mean zonal winds are a mixture of the diurnal tide and a zonal flow which is consistent with theoretical expectations.

Imaging Active Giants and Comparisons to Doppler Imaging

NASA Astrophysics Data System (ADS)

Roettenbacher, Rachael

2018-04-01

In the outer layers of cool, giant stars, stellar magnetism stifles convection creating localized starspots, analogous to sunspots. Because they frequently cover much larger regions of the stellar surface than sunspots, starspots of giant stars have been imaged using a variety of techniques to understand, for example, stellar magnetism, differential rotation, and spot evolution. Active giants have been imaged using photometric, spectroscopic, and, only recently, interferometric observations. Interferometry has provided a way to unambiguously see stellar surfaces without the degeneracies experienced by other methods. The only facility presently capable of obtaining the sub-milliarcsecond resolution necessary to not only resolve some giant stars, but also features on their surfaces is the Center for High-Angular Resolution Astronomy (CHARA) Array. Here, an overview will be given of the results of imaging active giants and details on the recent comparisons of simultaneous interferometric and Doppler images.

Is Doppler tissue velocity during early left ventricular filling preload independent?

NASA Technical Reports Server (NTRS)

Yalcin, F.; Kaftan, A.; Muderrisoglu, H.; Korkmaz, M. E.; Flachskampf, F.; Garcia, M.; Thomas, J. D.

2002-01-01

BACKGROUND: Transmitral Doppler flow indices are used to evaluate diastolic function. Recently, velocities measured by Doppler tissue imaging have been used as an index of left ventricular relaxation. OBJECTIVE: To determine whether Doppler tissue velocities are influenced by alterations in preload. METHODS: Left ventricular preload was altered in 17 patients (all men, mean (SD) age, 49 (8) years) during echocardiographic measurements of left ventricular end diastolic volume, maximum left atrial area, peak early Doppler filling velocity, and left ventricular myocardial velocities during early filling. Preload altering manoeuvres included Trendelenberg (stage 1), reverse Trendelenberg (stage 2), and amyl nitrate (stage 3). Systolic blood pressure was measured at each stage. RESULTS: In comparison with baseline, left ventricular end diastolic volume (p = 0.001), left atrial area (p = 0.003), peak early mitral Doppler filling velocity (p = 0.01), and systolic blood pressures (p = 0.001) were all changed by preload altering manoeuvres. Only left ventricular myocardial velocity during early filling remained unchanged by these manoeuvres. CONCLUSIONS: In contrast to standard transmitral Doppler filling indices, Doppler tissue early diastolic velocities are not significantly affected by physiological manoeuvres that alter preload. Thus Doppler tissue velocities during early left ventricular diastole may provide a better index of diastolic function in cardiac patients by providing a preload independent assessment of left ventricular filling.

Surface roughness measuring system. [synthetic aperture radar measurements of ocean wave height and terrain peaks

NASA Technical Reports Server (NTRS)

Jain, A. (Inventor)

1978-01-01

Significant height information of ocean waves, or peaks of rough terrain is obtained by compressing the radar signal over different widths of the available chirp or Doppler bandwidths, and cross-correlating one of these images with each of the others. Upon plotting a fixed (e.g., zero) component of the cross-correlation values as the spacing is increased over some empirically determined range, the system is calibrated. To measure height with the system, a spacing value is selected and a cross-correlation value is determined between two intensity images at a selected frequency spacing. The measured height is the slope of the cross-correlation value used. Both electronic and optical radar signal data compressors and cross-correlations are disclosed for implementation of the system.

Ultrasonography with color Doppler and power Doppler in the diagnosis of periapical lesions

PubMed Central

Goel, Sumit; Nagendrareddy, Suma Gundareddy; Raju, Manthena Srinivasa; Krishnojirao, Dayashankara Rao Jingade; Rastogi, Rajul; Mohan, Ravi Prakash Sasankoti; Gupta, Swati

2011-01-01

Aim: To evaluate the efficacy of ultrasonography (USG) with color Doppler and power Doppler applications over conventional radiography in the diagnosis of periapical lesions. Materials and Methods: Thirty patients having inflammatory periapical lesions of the maxillary or mandibular anterior teeth and requiring endodontic surgery were selected for inclusion in this study. All patients consented to participate in the study. We used conventional periapical radiographs as well as USG with color Doppler and power Doppler for the diagnosis of these lesions. Their diagnostic performances were compared against histopathologic examination. All data were compared and statistically analyzed. Results: USG examination with color Doppler and power Doppler identified 29 (19 cysts and 10 granulomas) of 30 periapical lesions accurately, with a sensitivity of 100% for cysts and 90.91% for granulomas and a specificity of 90.91% for cysts and 100% for granulomas. In comparison, conventional intraoral radiography identified only 21 lesions (sensitivity of 78.9% for cysts and 45.4% for granulomas and specificity of 45.4% for cysts and 78.9% for granulomas). There was definite correlation between the echotexture of the lesions and the histopathological features except in one case. Conclusions: USG imaging with color Doppler and power Doppler is superior to conventional intraoral radiographic methods for diagnosing the nature of periapical lesions in the anterior jaws. This study reveals the potential of USG examination in the study of other jaw lesions. PMID:22223940

Analysis of Hepatic Blood Flow Using Chaotic Models

PubMed Central

Cohen, M. E.; Moazamipour, H.; Hudson, D. L.; Anderson, M. F.

1990-01-01

The study of chaos in physical systems is an important new theoretical development in modeling which has emerged in the last fifteen years. It is particularly useful in explaining phenomena which arise in nonlinear dynamic systems, for which previous mathematical models produced results with intractable solutions. Analysis of blood flow is such an application. In the work described here, chaotic models are used to analyze hepatic artery and portal vein blood flow obtained from a pulsed Doppler ultrasonic flowmeter implanted in dogs. ImagesFigure 3

Laser Doppler technology applied to atmospheric environmental operating problems

NASA Technical Reports Server (NTRS)

Weaver, E. A.; Bilbro, J. W.; Dunkin, J. A.; Jeffreys, H. B.

1976-01-01

Carbon dioxide laser Doppler ground wind data were very favorably compared with data from standard anemometers. As a result of these measurements, two breadboard systems were developed for taking research data: a continuous wave velocimeter and a pulsed Doppler system. The scanning continuous wave laser Doppler velocimeter developed for detecting, tracking and measuring aircraft wake vortices was successfully tested at an airport where it located vortices to an accuracy of 3 meters at a range of 150 meters. The airborne pulsed laser Doppler system was developed to detect and measure clear air turbulence (CAT). This system was tested aboard an aircraft, but jet stream CAT was not encountered. However, low altitude turbulence in cumulus clouds near a mountain range was detected by the system and encountered by the aircraft at the predicted time.

Wind field measurement in the nonprecipitous regions surrounding storms by an airborne pulsed Doppler lidar system, appendix A

NASA Technical Reports Server (NTRS)

Bilbro, J. W.; Vaughan, W. W.

1980-01-01

Coherent Doppler lidar appears to hold great promise in contributing to the basic store of knowledge concerning flow field characteristics in the nonprecipitous regions surrounding severe storms. The Doppler lidar, through its ability to measure clear air returns, augments the conventional Doppler radar system, which is most useful in the precipitous regions of the storm. A brief description of the Doppler lidar severe storm measurement system is provided along with the technique to be used in performing the flow field measurements. The application of the lidar is addressed, and the planned measurement program is outlined.

Multi-point laser coherent detection system and its application on vibration measurement

NASA Astrophysics Data System (ADS)

Fu, Y.; Yang, C.; Xu, Y. J.; Liu, H.; Yan, K.; Guo, M.

2015-05-01

Laser Doppler vibrometry (LDV) is a well-known interferometric technique to measure the motions, vibrations and mode shapes of machine components and structures. The drawback of commercial LDV is that it can only offer a pointwise measurement. In order to build up a vibrometric image, a scanning device is normally adopted to scan the laser point in two spatial axes. These scanning laser Doppler vibrometers (SLDV) assume that the measurement conditions remain invariant while multiple and identical, sequential measurements are performed. This assumption makes SLDVs impractical to do measurement on transient events. In this paper, we introduce a new multiple-point laser coherent detection system based on spatial-encoding technology and fiber configuration. A simultaneous vibration measurement on multiple points is realized using a single photodetector. A prototype16-point laser coherent detection system is built and it is applied to measure the vibration of various objects, such as body of a car or a motorcycle when engine is on and under shock tests. The results show the prospect of multi-point laser coherent detection system in the area of nondestructive test and precise dynamic measurement.

Coherent Doppler lidar signal covariance including wind shear and wind turbulence

NASA Technical Reports Server (NTRS)

Frehlich, R. G.

1993-01-01

The performance of coherent Doppler lidar is determined by the statistics of the coherent Doppler signal. The derivation and calculation of the covariance of the Doppler lidar signal is presented for random atmospheric wind fields with wind shear. The random component is described by a Kolmogorov turbulence spectrum. The signal parameters are clarified for a general coherent Doppler lidar system. There are two distinct physical regimes: one where the transmitted pulse determines the signal statistics and the other where the wind field dominates the signal statistics. The Doppler shift of the signal is identified in terms of the wind field and system parameters.

[The role of ultrasonography in the investigation of male infertility].

PubMed

Fejes, Zsuzsanna; Pásztor, Norbert; Karczagi, Lilla; Brzózka, Ádám; Király, István; Morvay, Zita; Palkó, András

2018-05-01

Unintended childlessness affects approximately 9-15% of couples in the reproductive age. It is known that a remarkable proportion of infertility is caused by the disorders of the male reproductive functions. Diagnostic imaging methods and especially ultrasonography play a crucial role in the infertility work-up, the ultrasound examination has become the method of choice for imaging in diseases affecting the testis. With the development of high resolution transducers and technology using colour Doppler, pulsed Doppler, share wave elastography and strain elastography, it is now possible to make accurate diagnoses. However, the place of the new imaging methods in the algorithm of infertility check-up should be clearly defined. Orv Hetil. 2018; 159(21): 815-822.

Endoscopic high-resolution auto fluorescence imaging and optical coherence tomography of airways in vivo (Conference Presentation)

NASA Astrophysics Data System (ADS)

Pahlevaninezhad, Hamid; Lee, Anthony; Hohert, Geoffrey; Schwartz, Carley; Shaipanich, Tawimas; Ritchie, Alexander J.; Zhang, Wei; MacAulay, Calum E.; Lam, Stephen; Lane, Pierre M.

2016-03-01

In this work, we present multimodal imaging of peripheral airways in vivo using an endoscopic imaging system capable of co-registered optical coherence tomography and autofluorescence imaging (OCT-AFI). This system employs a 0.9 mm diameter double-clad fiber optic-based catheter for endoscopic imaging of small peripheral airways. Optical coherence tomography (OCT) can visualize detailed airway morphology in the lung periphery and autofluorescence imaging (AFI) can visualize fluorescent tissue components such as collagen and elastin, improving the detection of airway lesions. Results from in vivo imaging of 40 patients indicate that OCT and AFI offer complementary information that may increase the ability to identify pulmonary nodules in the lung periphery and improve the safety of biopsy collection by identifying large blood vessels. AFI can rapidly visualize in vivo vascular networks using fast scanning parameters resulting in vascular-sensitive imaging with less breathing/cardiac motion artifacts compared to Doppler OCT imaging. By providing complementary information about structure and function of tissue, OCT-AFI may improve site selection during biopsy collection in the lung periphery.

New spectroscopic and photometric observations of CV J0644+3344

NASA Astrophysics Data System (ADS)

Hernández Santisteban, J. V.

We report photometric and simultaneous spectroscopic observations of the cataclysmic variable J0644+3344 and present calibrated Doppler tomography results of the object. We have calibrated the spectra for slit losses using simultaneous photometry. This has been used to construct reliable Doppler images in the Halpha , Hbeta and He II 4686 Å@ emission lines. We have also performed a radial velocity analysis using these emission lines to derive the primary semi-amplitude and used a cophasing method to determine the secondary K_2 best value. We have improved the ephemeris of the object based on the published and our new photometric eclipse timings to obtain HJD=254474.7927+0.26937446E. We derived a K_1=123.2±6.6 {km s}-1 and K_2=205.4±6.7. Assuming a i>76, the orbital parameters are M_1=0.91±0.04 M⊙, M_2=0.83±0.04 M⊙ and a=2.10±0.03 R⊙. Based on the Doppler tomography we conclude that J0644+3344 is a nova-like SW Sex type system.

Non-invasive assessment of fibrosis using color Doppler ultrasound in patients with hepatitis C virus in the Amazon rainforest, Brazil.

PubMed

Leão, Jorge; Brock, Marianna; Castilho, Márcia; Scariot, André; Scariot, Ana; Braga, Wornei

2012-02-01

The purpose of this study was to correlate morphologic and hemodynamic Doppler ultrasound findings as indicators of the degree of inflammation and fibrosis and to diagnose chronic vital hepatitis complications and progression. A prospective, descriptive study of a case series was conducted that analyzed Doppler ultrasound images of the liver and portal system and used the portal vein congestion index, hepatic and splenic artery impedance indices, and the liver vascular index. Of 50 patients positive for antibodies against hepatitis C virus, morphologic changes highlighted increased hepatic parenchyma echogenicity in 24%, and increased gall blander echogenicity and wall thickness in 4%. The most common hemodynamic changes observed were reduced flow velocity in the portal vein trunk in 26%, congestion index changes in 12%, liver vascular index changes in 16%, and splenic and hepatic artery impedance index changes in 14%. These indices were shown to be associated with alanine aminotransferase levels, which suggested that they are important liver damage indicators in the early phase of infection with hepatitis C virus.

Non-Invasive Assessment of Fibrosis Using Color Doppler Ultrasound in Patients with Hepatitis C Virus in the Amazon Rainforest, Brazil

PubMed Central

Leão, Jorge; Brock, Marianna; Castilho, Márcia; Scariot, André; Scariot, Ana; Braga, Wornei

2012-01-01

The purpose of this study was to correlate morphologic and hemodynamic Doppler ultrasound findings as indicators of the degree of inflammation and fibrosis and to diagnose chronic vital hepatitis complications and progression. A prospective, descriptive study of a case series was conducted that analyzed Doppler ultrasound images of the liver and portal system and used the portal vein congestion index, hepatic and splenic artery impedance indices, and the liver vascular index. Of 50 patients positive for antibodies against hepatitis C virus, morphologic changes highlighted increased hepatic parenchyma echogenicity in 24%, and increased gall blander echogenicity and wall thickness in 4%. The most common hemodynamic changes observed were reduced flow velocity in the portal vein trunk in 26%, congestion index changes in 12%, liver vascular index changes in 16%, and splenic and hepatic artery impedance index changes in 14%. These indices were shown to be associated with alanine aminotransferase levels, which suggested that they are important liver damage indicators in the early phase of infection with hepatitis C virus. PMID:22302863

Deep skin structural and microcirculation imaging with extended-focus OCT

NASA Astrophysics Data System (ADS)

Blatter, Cedric; Grajciar, Branislav; Huber, Robert; Leitgeb, Rainer A.

2012-02-01

We present an extended focus OCT system for dermatologic applications that maintains high lateral resolution over a large depth range by using Bessel beam illumination. More, Bessel beams exhibit a self-reconstruction property that is particularly useful to avoid shadowing from surface structures such as hairs. High lateral resolution and high-speed measurement, thanks to a rapidly tuning swept source, allows not only for imaging of small skin structures in depth but also for comprehensive visualization of the small capillary network within the human skin in-vivo. We use this information for studying temporal vaso-responses to hypothermia. In contrast to other perfusion imaging methods such as laser Doppler imaging (LDI), OCT gives specific access to vascular responses in different vascular beds in depth.

Remote defect imaging for plate-like structures based on the scanning laser source technique

NASA Astrophysics Data System (ADS)

Hayashi, Takahiro; Maeda, Atsuya; Nakao, Shogo

2018-04-01

In defect imaging with a scanning laser source technique, the use of a fixed receiver realizes stable measurements of flexural waves generated by laser at multiple rastering points. This study discussed the defect imaging by remote measurements using a laser Doppler vibrometer as a receiver. Narrow-band burst waves were generated by modulating laser pulse trains of a fiber laser to enhance signal to noise ratio in frequency domain. Averaging three images obtained at three different frequencies suppressed spurious distributions due to resonance. The experimental system equipped with these newly-devised means enabled us to visualize defects and adhesive objects in plate-like structures such as a plate with complex geometries and a branch pipe.

Computer-generated imagery for 4-D meteorological data

NASA Technical Reports Server (NTRS)

Hibbard, William L.

1986-01-01

The University of Wisconsin-Madison Space Science and Engineering Center is developing animated stereo display terminals for use with McIDAS (Man-computer Interactive Data Access System). This paper describes image-generation techniques which have been developed to take maximum advantage of these terminals, integrating large quantities of four-dimensional meteorological data from balloon and satellite soundings, satellite images, Doppler and volumetric radar, and conventional surface observations. The images have been designed to use perspective, shading, hidden-surface removal, and transparency to augment the animation and stereo-display geometry. They create an illusion of a moving three-dimensional model of the atmosphere. This paper describes the design of these images and a number of rules of thumb for generating four-dimensional meteorological displays.

Dual-frequency ultrasound imaging and therapeutic bilaminar array using frequency selective isolation layer.

PubMed

Azuma, Takashi; Ogihara, Makoto; Kubota, Jun; Sasaki, Akira; Umemura, Shin-ichiro; Furuhata, Hiroshi

2010-05-01

A new ultrasound array transducer with two different optimal frequencies designed for diagnosis and therapy integration in Doppler imaging-based transcranial sonothrombolysis is described. Previous studies have shown that respective frequencies around 0.5 and 2 MHz are suitable for sonothrombolysis and Doppler imaging. Because of the small acoustic window available for transcranial ultrasound exposure, it is highly desirable that both therapeutic and diagnostic ultrasounds pass through the same aperture with high efficiency. To achieve such a dual-frequency array transducer, we propose a bilaminar array, having an array for imaging and another for therapy, with a frequency selective isolation layer between the two arrays. The function of this layer is to isolate the imaging array from the therapy array at 2 MHz without disturbing the 0.5-MHz ultrasound transmission. In this study, we first used a 1-D model including two lead zirconate titanate (PZT) layers separated by an isolation layer for intuitive understanding of the phenomena. After that, we optimized the acoustic impedance and thickness of the isolation layer by analyzing pulse propagation in a 2-D model by conducting a numerical simulation with commercially available software. The optimal acoustic impedance and thickness are 3 to 4 MRayI and lambda/10, respectively. On the basis of the optimization, a prototype array transducer was fabricated, and the spatial resolutions of the Doppler images it obtained were found to be practically the same as those obtained through conventional imaging array transducers.

Non-contact photoacoustic tomography with a laser Doppler vibrometer

NASA Astrophysics Data System (ADS)

Xu, Guan; Wang, Cheng; Feng, Ting; Oliver, David E.; Wang, Xueding

2014-03-01

Most concurrent photoacoustic tomography systems are based on traditional ultrasound measurement regime, which requires the contact or acoustic coupling material between the biological tissue and the ultrasound transducer. This study investigates the feasibility of non-contact measurement of photacoustic signals generated inside biomedical tissues by observing the vibrations at the surface of the tissues with a commercial laser Doppler vibrometer. The vibrometer with 0- 2MHz measurement bandwidth and 5 MHz sampling frequency was integrated to a conventional rotational PAT data acquisition system. The data acquisition of the vibrometer was synchronized to the laser illumination from an Nd:YAG laser with output at 532nm. The laser energy was tuned to 17.5mJ per square centimeter. The PA signals were acquired at 120 angular locations uniformly distributed around the scanned objects. The frequency response of the measurement system was first calibrated. 2-inch-diamater cylindrical phantoms containing small rubber plates and biological tissues were afterwards imaged. The phantoms were made from 5% intralipid solution in 10% porcine gelatin to simulate the light scattering in biological tissue and to backscatter the measurement laser from the vibrometer. Time-domain backprojection method was used for the image reconstruction. Experiments with real-tissue phantoms show that with laser illumination of 17.5 mJ/cm2 at 532 nm, the non-contact photoacoustic (PA) imaging system with 15dB detection bandwidth of 2.5 MHz can resolve spherical optical inclusions with dimension of 500μm and multi-layered structure with optical contrast in strongly scattering medium. The experiment results prompt the potential implementation of the non-contact PAT to achieve "photoacoustic camera".

SU-G-IeP3-10: Molecular Imaging with Clinical X-Ray Sources and Compton Cameras

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vernekohl, D; Ahmad, M; Chinn, G

2016-06-15

Purpose: The application of Compton cameras (CC) is a novel approach translating XFCT to a practical modality realized with clinical CT systems without the restriction of pencil beams. The dual modality design offers additional information without extra patient dose. The purpose of this work is to investigate the feasibility and efficacy of using CCs for volumetric x-ray fluorescence (XF) imaging by Monte Carlo (MC) simulations and statistical image reconstruction. Methods: The feasibility of a CC for imaging x-ray fluorescence emitted from targeted lesions is examined by MC simulations. 3 mm diameter water spheres with various gold concentrations and detector distancesmore » are placed inside the lung of an adult human phantom (MIRD) and are irradiated with both fan and cone-beam geometries. A sandwich design CC composed of Silicon and CdTe is used to image the gold nanoparticle distribution. The detection system comprises four 16×26 cm{sup 2} detector panels placed on the chest of a MIRD phantom. Constraints of energy-, spatial-resolution, clinical geometries and Doppler broadening are taken into account. Image reconstruction is performed with a list-mode MLEM algorithm with cone-projector on a GPU. Results: The comparison of reconstruction of cone- and fan-beam excitation shows that the spatial resolution is improved by 23% for fan-beams with significantly decreased processing time. Cone-beam excitation increases scatter content disturbing quantification of lesions near the body surface. Spatial resolution and detectability limit in the center of the lung is 8.7 mm and 20 fM for 50 nm diameter gold nanoparticles at 20 mGy. Conclusion: The implementation of XFCT with a CC is a feasible method for molecular imaging with high atomic number probes. Given constrains of detector resolutions, Doppler broadening, and limited exposure dose, spatial resolutions comparable with PET and molecular sensitivities in the fM range are realizable with current detector technology.« less

Analysis of the Sensitivity and Specificity of Noninvasive Imaging Tests for the Diagnosis of Renal Artery Stenosis

PubMed Central

Borelli, Flavio Antonio de Oliveira; Pinto, Ibraim M. F.; Amodeo, Celso; Smanio, Paola E. P.; Kambara, Antonio M.; Petisco, Ana Claudia G.; Moreira, Samuel M.; Paiva, Ricardo Calil; Lopes, Hugo Belotti; Sousa, Amanda G. M. R.

2013-01-01

Background Aging and atherosclerosis are related to renovascular hypertension in elderly individuals. Regardless of comorbidities, renal artery stenosis is itself an important cause of cardiovascular morbidity and mortality. Objective To define the sensitivity, specificity, positive predictive value, and negative predictive value of noninvasive imaging tests used in the diagnosis of renal artery stenosis. Methods In a group of 61 patients recruited, 122 arteries were analized, thus permitting the definition of sensitivity, specificity, and the relative contribution of each imaging study performed (Doppler, scintigraphy and computed tomographic angiography in comparison to renal arteriography). Results The mean age was 65.43 years (standard deviation: 8.7). Of the variables related to the study population that were compared to arteriography, two correlated with renal artery stenosis, renal dysfunction and triglycerides. The median glomerular filtration rate was 52.8 mL/min/m2. Doppler showed sensitivity of 82.90%, specificity of 70%, a positive predictive value of 85% and negative predictive value of 66.70%. For tomography, sensitivity was 66.70%, specificity 80%, positive predictive value 87.50% and negative predictive value 55.20%. With these findings, we could identify the imaging tests that best detected stenosis. Conclusion Tomography and Doppler showed good quality and efficacy in the diagnosis of renal artery stenosis, with Doppler having the advantage of not requiring the use of contrast medium for the assessment of a disease that is common in diabetics and is associated with renal dysfunction and severe left ventricular dysfunction. PMID:24061685

Update on imaging techniques in oculoplastics

PubMed Central

Cetinkaya, Altug

2012-01-01

Imaging is a beneficial aid to the oculoplastic surgeon especially in orbital and lacrimal disorders when the pathology is not visible from outside. It is a powerful tool that may be benefited in not only diagnosis but also management and follow-up. The most common imaging modalities required are CT and MRI, with CT being more frequently ordered by oculoplastic surgeons. Improvements in technology enabled the acquisition times to shorten incredibly. Radiologists can now obtain images with superb resolution, and isolate the site and tissue of interest from other structures with special techniques. Better contrast agents and 3D imaging capabilities make complicated cases easier to identify. Color Doppler imaging is becoming more popular both for research and clinical purposes. Magnetic resonance angiography (MRA) added so much to the vascular system imaging recently. Although angiography is still the gold standard, new software and techniques rendered MRA as valuable as angiography in most circumstances. Stereotactic navigation, although in use for a long time, recently became the focus of interest for the oculoplastic surgeon especially in orbital decompressions. Improvements in radiology and nuclear medicine techniques of lacrimal drainage system imaging provided more detailed analysis of the system. PMID:23961020

Trans-skull ultrasonic Doppler system aided by fuzzy logic

NASA Astrophysics Data System (ADS)

Hata, Yutaka; Nakamura, Masato; Yagi, Naomi; Ishikawa, Tomomoto

2012-06-01

This paper describes a trans-skull ultrasonic Doppler system for measuring the blood flow direction in brain under skull. In this system, we use an ultrasonic array probe with the center frequency of 1.0 MHz. The system determines the fuzzy degree of blood flow by Doppler Effect, thereby it locates blood vessel. This Doppler Effect is examined by the center of gravity shift of the frequency magnitudes. In in-vitro experiment, a cow bone was employed as the skull, and three silicon tubes were done as blood vessels, and bubble in water as blood. We received the ultrasonic waves through a protein, the skull and silicon tubes in order. In the system, fuzzy degrees are determined with respect to the Doppler shift, amplitude of the waves and attenuation of the tissues. The fuzzy degrees of bone and blood direction are calculated by them. The experimental results showed that the system successfully visualized the skull and flow direction, compared with the location and flow direction of the phantom. Thus, it detected the flow direction by Doppler Effect under skull, and automatically extracted the region of skull and blood vessel.

Improved Atmospheric Boundary Layer Observations of Tropical Cyclones with the Imaging Wind and Rain Airborne Profiler

NASA Technical Reports Server (NTRS)

Fernandez, D. Esteban; Chang, P.; Carswel, J.; Contreras, R.; Chu, T.; Asuzu, P.; Black, P.; Marks, F.

2006-01-01

The Imaging Wind and Rain Arborne Profilers (IWRAP) is a dual-frequency, conically-scanning Doppler radar that measures high-resolution, dual-polarized, multi-beam C- and Ku-band reflectivity and Doppler velocity profiles of the atmospheric boundary layer (ABL) within the inner core of hurricanes.From the datasets acquired during the 2002 through 20O5 hurricane seasons as part of the ONR Coupled Boundary Layer Air-Sea Transfer (CBLAST) program and the NOAA/NESDIS Ocean Winds and Rain experiments, very high resolution radar observations of hurricanes have been acquired and made available to the CBLAST community. Of particular interest am the ABL wind fields and 3-D structures found within the inner core of hurricanes. As a result of these analysis, a limitation in the ability to retrieve the ABL wind field at very low altitudes was identified. This paper shows how this limitation has been removed and presents initial results demonstrating its new capabilities to derive the ABL wind field within the inner are of hurricanes to much lower altitudes than the ones the original system was capable of.

Speckle tracking evaluation of right ventricular functions in children with sickle cell disease.

PubMed

Tolba, Osama Abd Rab Elrasol; El-Shanshory, Mohamed Ramadan; El-Gamasy, Mohamed Abd Elaziz; El-Shehaby, Walid Ahmed

2017-01-01

Cardiac dysfunction is a risk factor for death in patients with sickle cell disease (SCD). Aim of the work is to evaluate the right ventricular systolic and diastolic functions by tissue Doppler and speckling tracking imaging in children with SCD. Thirty children with SCD and thirty controls were subjected to clinical, laboratory evaluations, and echocardiographic study using GE Vivid 7 (GE Medical System, Horten, Norway with a 3.5-MHz multifrequency transducer) including; Two-dimensional and tissue Doppler echocardiographic study (lateral tricuspid valve annulus peak E' velocity, lateral tricuspid valve annulus peak A' velocity, E'/A' ratio, isovolumetric relaxation time, lateral tricuspid valve annulus S' and septal S' waves and peak longitudinal systolic strain [PLSS] and time to PLSS) were done in six right ventricular segments. There was a significant decrease in right ventricular systolic and diastolic function in patients group when compared to controls. Children with SCD have impaired right ventricular systolic and diastolic functions when compared to healthy children with early evaluation of the systolic dysfunction by speckle tracking imaging technique.

Noninvasive assessment of normal carotid bifurcation hemodynamics with color-flow ultrasound imaging.

PubMed

Zierler, R E; Phillips, D J; Beach, K W; Primozich, J F; Strandness, D E

1987-08-01

The combination of a B-mode imaging system and a single range-gate pulsed Doppler flow velocity detector (duplex scanner) has become the standard noninvasive method for assessing the extracranial carotid artery. However, a significant limitation of this approach is the small area of vessel lumen that can be evaluated at any one time. This report describes a new duplex instrument that displays blood flow as colors superimposed on a real-time B-mode image. Returning echoes from a linear array of transducers are continuously processed for amplitude and phase. Changes in phase are produced by tissue motion and are used to calculate Doppler shift frequency. This results in a color assignment: red and blue indicate direction of flow with respect to the ultrasound beam, and lighter shades represent higher velocities. The carotid bifurcations of 10 normal subjects were studied. Changes in flow velocities across the arterial lumen were clearly visualized as varying shades of red or blue during the cardiac cycle. A region of flow separation was observed in all proximal internal carotids as a blue area located along the outer wall of the bulb. Thus, it is possible to detect the localized flow patterns that characterize normal carotid arteries. Other advantages of color-flow imaging include the ability to rapidly identify the carotid bifurcation branches and any associated anatomic variations.

Doppler-corrected differential detection system

NASA Technical Reports Server (NTRS)

Simon, Marvin K. (Inventor); Divsalar, Dariush (Inventor)

1991-01-01

Doppler in a communication system operating with a multiple differential phase-shift-keyed format (MDPSK) creates an adverse phase shift in an incoming signal. An open loop frequency estimation is derived from a Doppler-contaminated incoming signal. Based upon the recognition that, whereas the change in phase of the received signal over a full symbol contains both the differentially encoded data and the Doppler induced phase shift, the same change in phase over half a symbol (within a given symbol interval) contains only the Doppler induced phase shift, and the Doppler effect can be estimated and removed from the incoming signal. Doppler correction occurs prior to the receiver's final output of decoded data. A multiphase system can operate with two samplings per symbol interval at no penalty in signal-to-noise ratio provided that an ideal low pass pre-detection filter is employed, and two samples, at 1/4 and 3/4 of the symbol interval T sub s, are taken and summed together prior to incoming signal data detection.

Department of the Navy Supporting Data for Fiscal Year 1983 Budget Estimates Descriptive Summaries Submitted to Congress February 1982. Research, Development, Test & Evaluation, Navy. Book 1 of 3. Technology Base, Advanced Technology Development, Strategic Programs.

DTIC Science & Technology

1982-02-01

optimization methods have been developed for problems in production and distribution modeling including design and evaluation of storage alternatives under...and winds using high frequency , X-band doppler, pulse -limited, and Delta-K radars. Development of millimeter-wave radiometric imaging systems and...generic system design concept for a system capable of defending the Fleet from the high angle threat 1.4 The first model of the drive system for a

Noncoherent Doppler tracking: first flight results

NASA Astrophysics Data System (ADS)

DeBoy, Christopher C.; Robert Jensen, J.; Asher, Mark S.

2005-01-01

Noncoherent Doppler tracking has been devised as a means to achieve highly accurate, two-way Doppler measurements with a simple, transceiver-based communications system. This technique has been flown as an experiment on the Thermosphere, Ionosphere, Mesosphere, Energetics and Dynamics (TIMED) spacecraft, (launched 7 December 2001), as the operational technique for Doppler tracking on CONTOUR, and is baselined on several future deep space missions at JHU/APL. This paper reports on initial results from a series of successful tests of this technique between the TIMED spacecraft and NASA ground stations in the Deep Space Network. It also examines the advantages that noncoherent Doppler tracking and a transceiver-based system may offer to small satellite systems, including reduced cost, mass, and power.

Functional Spectral Domain Optical Coherence Tomography imaging

NASA Astrophysics Data System (ADS)

Bower, Bradley A.

Spectral Domain Optical Coherence Tomography (SDOCT) is a high-speed, high resolution imaging modality capable of structural and functional characterization of tissue microstructure. SDOCT fills a niche between histology and ultrasound imaging, providing non-contact, non-invasive backscattering amplitude and phase from a sample. Due to the translucent nature of the tissue, ophthalmic imaging is an ideal space for SDOCT imaging. Structural imaging of the retina has provided new insights into ophthalmic disease. The phase component of SDOCT images remains largely underexplored, though. While Doppler SDOCT has been explored in a research setting, it has yet to gain traction in the clinic. Other, functional exploitations of the phase are possible and necessary to expand the utility of SDOCT. Spectral Domain Phase Microscopy (SDPM) is an extension of SDOCT that is capable of resolving sub-wavelength displacements within a focal volume. Application of sub-wavelength displacement measurement imaging could provide a new method for non-invasive optophysiological measurement. This body of work encompasses both hardware and software design and development for implementation of SDOCT. Structural imaging was proven in both the lab and the clinic. Coarse phase changes associated with Doppler flow frequency shifts were recorded and a study was conducted to validate Doppler measurement. Fine phase changes were explored through SDPM applications. Preliminary optophysiology data was acquired to study the potential of sub-wavelength measurements in the retina. To remove the complexity associated with in-vivo human retinal imaging, a first principles approach using isolated nerve samples was applied using standard SDPM and a depthencoded technique for measuring conduction velocity. Results from amplitude as well as both coarse and fine phase processing are presented. In-vivo optophysiology using SDPM is a promising avenue for exploration, and projects furthering or extending this body of work are discussed.

Verification of Wind Measurement to 450-Meter Altitude with Mobile Laser Doppler System

DOT National Transportation Integrated Search

1977-12-01

The Lockheed mobile atmospheric unit is a laser Doppler velocimeter system designed for the remote sensing of winds. The capability of the laser Doppler velocimeter accurately to measure winds to 150-meter altitude has been previously demonstrated. T...

[A Comparison Study on Early Damage Detection of Left Ventricular Function Based on Doppler Imaging Method for Children with Tumor].

PubMed

Liu, Ying; Zhang, Haowei; Zhang, Hang

2015-12-01

The early damage detection and evaluation are of great significance in treatment and prognosis to the left ventricular function for children with tumor. In this paper, it is reported that the early damage of the left ventricular function was observed by pulsed wave Doppler (PWD) and tissue Doppler imaging (TDI) in our laboratory. Eighty children half a year to fourteen years old were included in this study. The cardiac function indices in chemotherapy group and control group were measured and compared. The results showed that there was significant difference in mitral and tricuspid annulus flow spectrum between the two groups. Compared with PWD,TDI is more prompt, objective and accurate in detecting early damage of left ventricular function in children with tumor. And TDI is a good method for early identification of ventricular function damage in children with tumor.

Two- and three-dimensional transvaginal ultrasound with power Doppler angiography and gel infusion sonography for diagnosis of endometrial malignancy.

PubMed

Dueholm, M; Christensen, J W; Rydbjerg, S; Hansen, E S; Ørtoft, G

2015-06-01

To evaluate the diagnostic efficiency of two-dimensional (2D) and three-dimensional (3D) transvaginal ultrasonography, power Doppler angiography (PDA) and gel infusion sonography (GIS) at offline analysis for recognition of malignant endometrium compared with real-time evaluation during scanning, and to determine optimal image parameters at 3D analysis. One hundred and sixty-nine consecutive women with postmenopausal bleeding and endometrial thickness ≥ 5 mm underwent systematic evaluation of endometrial pattern on 2D imaging, and 2D videoclips and 3D volumes were later analyzed offline. Histopathological findings at hysteroscopy or hysterectomy were used as the reference standard. The efficiency of the different techniques for diagnosis of malignancy was calculated and compared. 3D image parameters, endometrial volume and 3D vascular indices were assessed. Optimal 3D image parameters were transformed by logistic regression into a risk of endometrial cancer (REC) score, including scores for body mass index, endometrial thickness and endometrial morphology at gray-scale and PDA and GIS. Offline 2D and 3D analysis were equivalent, but had lower diagnostic performance compared with real-time evaluation during scanning. Their diagnostic performance was not markedly improved by the addition of PDA or GIS, but their efficiency was comparable with that of real-time 2D-GIS in offline examinations of good image quality. On logistic regression, the 3D parameters from the REC-score system had the highest diagnostic efficiency. The area under the curve of the REC-score system at 3D-GIS (0.89) was not improved by inclusion of vascular indices or endometrial volume calculations. Real-time evaluation during scanning is most efficient, but offline 2D and 3D analysis is useful for prediction of endometrial cancer when good image quality can be obtained. The diagnostic efficiency at 3D analysis may be improved by use of REC-scoring systems, without the need for calculation of vascular indices or endometrial volume. The optimal imaging modality appears to be real-time 2D-GIS. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.

Optic probe for multiple angle image capture and optional stereo imaging

DOEpatents

Malone, Robert M.; Kaufman, Morris I.

2016-11-29

A probe including a multiple lens array is disclosed to measure velocity distribution of a moving surface along many lines of sight. Laser light, directed to the moving surface is reflected back from the surface and is Doppler shifted, collected into the array, and then directed to detection equipment through optic fibers. The received light is mixed with reference laser light and using photonic Doppler velocimetry, a continuous time record of the surface movement is obtained. An array of single-mode optical fibers provides an optic signal to the multiple lens array. Numerous fibers in a fiber array project numerous rays to establish many measurement points at numerous different locations. One or more lens groups may be replaced with imaging lenses so a stereo image of the moving surface can be recorded. Imaging a portion of the surface during initial travel can determine whether the surface is breaking up.

Body mapping of human cutaneous microcirculatory perfusion using a real-time laser Doppler imager.

PubMed

Harbi, Pascal; Thacher, Tyler

2013-03-01

There are many pathologies and/or surgical situations where understanding how cutaneous capillary blood flow is behaving would be of clinical benefit. Laser Doppler imaging (LDI) has long been considered an ideal candidate for this yet was never widely adopted. The technology was deemed too slow, needing minutes to record one image. Here, we present the use of a new, real-time LDI, which is sensitive enough to resolve pulsatile blood flow in the microcirculation and can record images and videos instantaneously. We show that when comparing the ratios of absolute perfusion images from different regions of the body, remarkably reproducible data can be obtained when looking at a control population of male volunteers. In the future, we plan to add more control and diseased groups, effectively giving the clinician a non-invasive, safe and easy-to-use diagnostic for assessing the extent of microcirculatory disorders and high-risk surgical situations.

Combined DEM Extration Method from StereoSAR and InSAR

NASA Astrophysics Data System (ADS)

Zhao, Z.; Zhang, J. X.; Duan, M. Y.; Huang, G. M.; Yang, S. C.

2015-06-01

A pair of SAR images acquired from different positions can be used to generate digital elevation model (DEM). Two techniques exploiting this characteristic have been introduced: stereo SAR and interferometric SAR. They permit to recover the third dimension (topography) and, at the same time, to identify the absolute position (geolocation) of pixels included in the imaged area, thus allowing the generation of DEMs. In this paper, StereoSAR and InSAR combined adjustment model are constructed, and unify DEM extraction from InSAR and StereoSAR into the same coordinate system, and then improve three dimensional positioning accuracy of the target. We assume that there are four images 1, 2, 3 and 4. One pair of SAR images 1,2 meet the required conditions for InSAR technology, while the other pair of SAR images 3,4 can form stereo image pairs. The phase model is based on InSAR rigorous imaging geometric model. The master image 1 and the slave image 2 will be used in InSAR processing, but the slave image 2 is only used in the course of establishment, and the pixels of the slave image 2 are relevant to the corresponding pixels of the master image 1 through image coregistration coefficient, and it calculates the corresponding phase. It doesn't require the slave image in the construction of the phase model. In Range-Doppler (RD) model, the range equation and Doppler equation are a function of target geolocation, while in the phase equation, the phase is also a function of target geolocation. We exploit combined adjustment model to deviation of target geolocation, thus the problem of target solution is changed to solve three unkonwns through seven equations. The model was tested for DEM extraction under spaceborne InSAR and StereoSAR data and compared with InSAR and StereoSAR methods respectively. The results showed that the model delivered a better performance on experimental imagery and can be used for DEM extraction applications.

Development of a Hybrid Magnetic Resonance and Ultrasound Imaging System

PubMed Central

Sherwood, Victoria; Rivens, Ian; Collins, David J.; Leach, Martin O.; ter Haar, Gail R.

2014-01-01

A system which allows magnetic resonance (MR) and ultrasound (US) image data to be acquired simultaneously has been developed. B-mode and Doppler US were performed inside the bore of a clinical 1.5 T MRI scanner using a clinical 1–4 MHz US transducer with an 8-metre cable. Susceptibility artefacts and RF noise were introduced into MR images by the US imaging system. RF noise was minimised by using aluminium foil to shield the transducer. A study of MR and B-mode US image signal-to-noise ratio (SNR) as a function of transducer-phantom separation was performed using a gel phantom. This revealed that a 4 cm separation between the phantom surface and the transducer was sufficient to minimise the effect of the susceptibility artefact in MR images. MR-US imaging was demonstrated in vivo with the aid of a 2 mm VeroWhite 3D-printed spherical target placed over the thigh muscle of a rat. The target allowed single-point registration of MR and US images in the axial plane to be performed. The system was subsequently demonstrated as a tool for the targeting and visualisation of high intensity focused ultrasound exposure in the rat thigh muscle. PMID:25177702

Analysis of placenta vascularization in patients with uterine altered artery Doppler flow velocity exams.

PubMed

Gilio, Daniel Bruno; Miranda Corrêa, Rosana Rosa; Souza de Oliveira Guimarães, Camila; Peres, Luiz Cesar; Marques Salge, Ana Karina; Cavellani, Camila Lourencini; de Paula Antunes Teixeira, Vicente; Costa da Cunha Castro, Eumenia

2009-08-01

One of the frequent questions in obstetric practice is to determine placental vascular changes that may account for abnormal Doppler flow velocity alterations in maternal uterine vessels from women and fetuses without pregnancy pathology. A retrospective morphometric study was realized using 27 placentas from patients submitted for Doppler flow velocity exam during pregnancy. The placentas were morphologically examined using hematoxylin-eosin staining. Measurements of villi were made with the use of a video camera coupled to a common light microscope and a computer with automatic image analyzing software. Of the 27 placentas, 13 (48%) were of patients showing unaltered Doppler and 14 (52%) showing altered Doppler. The number of stem villi vessels was significantly larger in the placentas of patients with Doppler exam alterations (P = 0.003). This group also presented greater stem villi vessel thickness, although without significant difference. The number of intermediary and terminal villi vessels was greater in the placentas of patients with altered Doppler exams (P < 0.001), and a greater terminal villi area was observed in these cases (P < 0.001). The morphological proof that uterine artery Doppler flow velocity exam alterations are associated with placental vascular alterations demonstrates the importance of this exam during prenatal care, even in the absence of maternal-fetal alterations.

Echocardiographic Evaluation of Left Atrial Mechanics: Function, History, Novel Techniques, Advantages, and Pitfalls.

PubMed

Leischik, Roman; Littwitz, Henning; Dworrak, Birgit; Garg, Pankaj; Zhu, Meihua; Sahn, David J; Horlitz, Marc

2015-01-01

Left atrial (LA) functional analysis has an established role in assessing left ventricular diastolic function. The current standard echocardiographic parameters used to study left ventricular diastolic function include pulsed-wave Doppler mitral inflow analysis, tissue Doppler imaging measurements, and LA dimension estimation. However, the above-mentioned parameters do not directly quantify LA performance. Deformation studies using strain and strain-rate imaging to assess LA function were validated in previous research, but this technique is not currently used in routine clinical practice. This review discusses the history, importance, and pitfalls of strain technology for the analysis of LA mechanics.

Doppler flow imaging of cytoplasmic streaming using spectral domain phase microscopy

NASA Astrophysics Data System (ADS)

Choma, Michael A.; Ellerbee, Audrey K.; Yazdanfar, Siavash; Izatt, Joseph A.

2006-03-01

Spectral domain phase microscopy (SDPM) is a function extension of spectral domain optical coherence tomography. SDPM achieves exquisite levels of phase stability by employing common-path interferometry. We discuss the theory and limitations of Doppler flow imaging using SDPM, demonstrate monitoring the thermal contraction of a glass sample with nanometer per second velocity sensitivity, and apply this technique to measurement of cytoplasmic streaming in an Amoeba proteus pseudopod. We observe reversal of cytoplasmic flow induced by extracellular CaCl2, and report results that suggest parabolic flow of cytoplasm in the A. proteus pseudopod.

The Novel Nonlinear Adaptive Doppler Shift Estimation Technique and the Coherent Doppler Lidar System Validation Lidar

NASA Technical Reports Server (NTRS)

Beyon, Jeffrey Y.; Koch, Grady J.

2006-01-01

The signal processing aspect of a 2-m wavelength coherent Doppler lidar system under development at NASA Langley Research Center in Virginia is investigated in this paper. The lidar system is named VALIDAR (validation lidar) and its signal processing program estimates and displays various wind parameters in real-time as data acquisition occurs. The goal is to improve the quality of the current estimates such as power, Doppler shift, wind speed, and wind direction, especially in low signal-to-noise-ratio (SNR) regime. A novel Nonlinear Adaptive Doppler Shift Estimation Technique (NADSET) is developed on such behalf and its performance is analyzed using the wind data acquired over a long period of time by VALIDAR. The quality of Doppler shift and power estimations by conventional Fourier-transform-based spectrum estimation methods deteriorates rapidly as SNR decreases. NADSET compensates such deterioration in the quality of wind parameter estimates by adaptively utilizing the statistics of Doppler shift estimate in a strong SNR range and identifying sporadic range bins where good Doppler shift estimates are found. The authenticity of NADSET is established by comparing the trend of wind parameters with and without NADSET applied to the long-period lidar return data.

New echocardiographic windows for quantitative determination of aortic regurgitation volume using color Doppler flow convergence and vena contracta

NASA Technical Reports Server (NTRS)

Shiota, T.; Jones, M.; Agler, D. A.; McDonald, R. W.; Marcella, C. P.; Qin, J. X.; Zetts, A. D.; Greenberg, N. L.; Cardon, L. A.; Sun, J. P.;

New echocardiographic windows for quantitative determination of aortic regurgitation volume using color Doppler flow convergence and vena contracta.

PubMed

Shiota, T; Jones, M; Agler, D A; McDonald, R W; Marcella, C P; Qin, J X; Zetts, A D; Greenberg, N L; Cardon, L A; Sun, J P; Sahn, D J; Thomas, J D

1999-04-01

Color Doppler images of aortic regurgitation (AR) flow acceleration, flow convergence (FC), and the vena contracta (VC) have been reported to be useful for evaluating severity of AR. However, clinical application of these methods has been limited because of the difficulty in clearly imaging the FC and VC. This study aimed to explore new windows for imaging the FC and VC to evaluate AR volumes in patients and to validate this in animals with chronic AR. Forty patients with AR and 17 hemodynamic states in 4 sheep with strictly quantified AR volumes were evaluated. A Toshiba SSH 380A with a 3.75-MHz transducer was used to image the FC and VC. After routine echo Doppler imaging, patients were repositioned in the right lateral decubitus position, and the FC and VC were imaged from high right parasternal windows. In only 15 of the 40 patients was it possible to image clearly and measure accurately the FC and VC from conventional (left decubitus) apical or parasternal views. In contrast, 31 of 40 patients had clearly imaged FC regions and VCs using the new windows. In patients, AR volumes derived from the FC and VC methods combined with continuous velocity agreed well with each other (r = 0.97, mean difference = -7.9 ml +/- 9.9 ml/beat). In chronic animal model studies, AR volumes derived from both the VC and the FC agreed well with the electromagnetically derived AR volumes (r = 0.92, mean difference = -1.3 +/- 4.0 ml/beat). By imaging from high right parasternal windows in the right decubitus position, complementary use of the FC and VC methods can provide clinically valuable information about AR volumes.

Depth-encoded dual beam phase-resolved Doppler OCT for Doppler-angle-independent flow velocity measurement

NASA Astrophysics Data System (ADS)

Qian, Jie; Cheng, Wei; Cao, Zhaoyuan; Chen, Xinjian; Mo, Jianhua

2017-02-01

Phase-resolved Doppler optical coherence tomography (PR-D-OCT) is a functional OCT imaging technique that can provide high-speed and high-resolution depth-resolved measurement on flow in biological materials. However, a common problem with conventional PR-D-OCT is that this technique often measures the flow motion projected onto the OCT beam path. In other words, it needs the projection angle to extract the absolute velocity from PR-D-OCT measurement. In this paper, we proposed a novel dual-beam PR-D-OCT method to measure absolute flow velocity without separate measurement on the projection angle. Two parallel light beams are created in sample arm and focused into the sample at two different incident angles. The images produced by these two beams are encoded to different depths in single B-scan. Then the Doppler signals picked up by the two beams together with the incident angle difference can be used to calculate the absolute velocity. We validated our approach in vitro on an artificial flow phantom with our home-built 1060 nm swept source OCT. Experimental results demonstrated that our method can provide an accurate measurement of absolute flow velocity with independency on the projection angle.

Imaging thermal expansion and retinal tissue changes during photocoagulation by high speed OCT

PubMed Central

Müller, Heike H.; Ptaszynski, Lars; Schlott, Kerstin; Debbeler, Christina; Bever, Marco; Koinzer, Stefan; Birngruber, Reginald; Brinkmann, Ralf; Hüttmann, Gereon

2012-01-01

Visualizing retinal photocoagulation by real-time OCT measurements may considerably improve the understanding of thermally induced tissue changes and might enable a better reproducibility of the ocular laser treatment. High speed Doppler OCT with 860 frames per second imaged tissue changes in the fundus of enucleated porcine eyes during laser irradiation. Tissue motion, measured by Doppler OCT with nanometer resolution, was correlated with the temperature increase, which was measured non-invasively by optoacoustics. In enucleated eyes, the increase of the OCT signal near the retinal pigment epithelium (RPE) corresponded well to the macroscopically visible whitening of the tissue. At low irradiance, Doppler OCT revealed additionally a reversible thermal expansion of the retina. At higher irradiance additional movement due to irreversible tissue changes was observed. Measurements of the tissue expansion were also possible in vivo in a rabbit with submicrometer resolution when global tissue motion was compensated. Doppler OCT may be used for spatially resolved measurements of retinal temperature increases and thermally induced tissue changes. It can play an important role in understanding the mechanisms of photocoagulation and, eventually, lead to new strategies for retinal laser treatments. PMID:22567594

Test Bed Doppler Wind Lidar and Intercomparison Facility At NASA Langley Research Center

NASA Technical Reports Server (NTRS)

Kavaya, Michael J.; Koch, Grady J.; Petros, Mulugeta; Barnes, Bruce W.; Beyon, Jeffrey; Amzajerdian, Farzin; Yu, Ji-Rong; Singh, Upendra N.

2004-01-01

State of the art 2-micron lasers and other lidar components under development by NASA are being demonstrated and validated in a mobile test bed Doppler wind lidar. A lidar intercomparison facility has been developed to ensure parallel alignment of up to 4 Doppler lidar systems while measuring wind. Investigations of the new components; their operation in a complete system; systematic and random errors; the hybrid (joint coherent and direct detection) approach to global wind measurement; and atmospheric wind behavior are planned. Future uses of the VALIDAR (VALIDation LIDAR) mobile lidar may include comparison with the data from an airborne Doppler wind lidar in preparation for validation by the airborne system of an earth orbiting Doppler wind lidar sensor.

Wandering spleen in children: a report of 3 cases and a brief literature review underlining the importance of diagnostic imaging.

PubMed

Lombardi, Roberta; Menchini, Laura; Corneli, Teresa; Magistrelli, Andrea; Accinni, Antonella; Monti, Lidia; Tomà, Paolo

2014-03-01

Wandering spleen is a rare condition in children that is often caused by loss or weakening of the splenic ligaments. Its clinical presentation is variable; 64% of children with wandering spleen have splenic torsion as a complication. To provide up-to-date information on the diagnosis, clinical management and diagnostic imaging approaches for wandering spleen in infants and children and to underline the importance of color Doppler US and CT in providing important information for patient management. We report a series of three children with wandering spleen treated at our children's hospital over the last 6 years. All three underwent clinical evaluation, color Doppler US and CT and were surgically treated. We also reviewed 40 articles that included 55 patients younger than 18 years reported in the Medline database from 2002 to 2012. We correlated pathological data with imaging findings. Color Doppler US, the first imaging modality in investigating abdominal symptoms in children with suspected wandering spleen, yielded a diagnostic sensitivity of 54.9%, whereas CT achieved about 71.7%. Radiologic evaluation has a major role in confirming the diagnosis of a suspected wandering spleen and avoiding potentially life-threatening complications requiring immediate surgery.

Myocardial left ventricular dysfunction in patients with systemic lupus erythematosus: new insights from tissue Doppler and strain imaging.

PubMed

Buss, Sebastian J; Wolf, David; Korosoglou, Grigorios; Max, Regina; Weiss, Celine S; Fischer, Christian; Schellberg, Dieter; Zugck, Christian; Kuecherer, Helmut F; Lorenz, Hanns-Martin; Katus, Hugo A; Hardt, Stefan E; Hansen, Alexander

2010-01-01

Systemic lupus erythematosus (SLE) is associated with high cardiovascular morbidity and mortality. Cardiovascular involvement is frequently underestimated by routine imaging techniques. Our aim was to determine if new echocardiographic imaging modalities like tissue Doppler (TDI), strain rate (SRR), and strain (SRI) imaging detect abnormalities in left ventricular (LV) function in asymptomatic patients with SLE. Sixty-seven young patients with SLE (mean age 42 +/- 10 yrs) without typical symptoms or signs of heart failure or angina, and a matched healthy control group (n = 40), underwent standard transthoracic echocardiography, TDI, SRR, and SRI imaging of the LV as well as assessment of disease characteristics. Despite findings within the normal range on routine standard 2-dimensional echocardiography, SLE was associated with significantly impaired systolic and diastolic myocardial velocities of the LV measured by TDI [mean global TDI: systolic (s): 2.9 +/- 0.9 vs 3.9 +/- 0.7 cm/s, p < 0.05; early (e): 4.3 +/- 1.5 vs 6.3 +/- 1.3 cm/s, p < 0.05; late (a): 2.9 +/- 0.8 vs 3.4 +/- 0.8 cm/s, p < 0.05; values +/- SD); SRR (s: -0.8 +/- 0.1 vs -1.1 +/- 0.1 s(-1); e: 1.1 +/- 0.2 vs 1.6 +/- 0.3 s(-1); a: 0.7 +/- 0.1 vs 1.0 +/- 0.2 s(-1); all p < 0.05); and SR (-15.11 +/- 2.2% vs -19.7 +/- 1.9%; p < 0.05) compared to the control group. Further, elevated disease activity, measured with the ECLAM and the SLEDAI score, resulted in significantly lower values for LV longitudinal function measured by SRR and SR, but not by TDI. SLE is associated with a significant impairment of systolic and diastolic LV longitudinal function in patients without cardiac symptoms. New imaging modalities provide earlier insight into cardiovascular involvement in SLE and seem to be superior to standard echocardiography to detect subclinical myocardial disease.

Optical Coherence Tomography for Brain Imaging

NASA Astrophysics Data System (ADS)

Liu, Gangjun; Chen, Zhongping

Recently, there has been growing interest in using OCT for brain imaging. A feasibility study of OCT for guiding deep brain probes has found that OCT can differentiate the white matter and gray matter because the white matter tends to have a higher peak reflectivity and steeper attenuation rate compared to gray matter. In vivo 3D visualization of the layered organization of a rat olfactory bulb with OCT has been demonstrated. OCT has been used for single myelin fiber imaging in living rodents without labeling. The refractive index in the rat somatosensory cortex has also been measured with OCT. In addition, functional extension of OCT, such as Doppler-OCT (D-OCT), polarization sensitive-OCT (PS-OCT), and phase-resolved-OCT (PR-OCT), can image and quantify physiological parameters in addition to the morphological structure image. Based on the scattering changes during neural activity, OCT has been used to measure the functional activation in neuronal tissues. PS-OCT, which combines polarization sensitive detection with OCT to determine tissue birefringence, has been used for the localization of nerve fiber bundles and the mapping of micrometer-scale fiber pathways in the brain. D-OCT, also named optical Doppler tomography (ODT), combines the Doppler principle with OCT to obtain high resolution tomographic images of moving constituents in highly scattering biological tissues. D-OCT has been successfully used to image cortical blood flow and map the blood vessel network for brain research. In this chapter, the principle and technology of OCT and D-OCT are reviewed and examples of potential applications are described.

Radar images of the Moon at 6-meter wavelength

NASA Astrophysics Data System (ADS)

Vierinen, Juha; Tveito, Torbjørn; Gustavsson, Björn; Kesaraju, Saiveena; Milla, Marco

2017-11-01

We present new range-Doppler images of the Moon using 6-mwavelength. The radar images were obtained using the Jicamarca Radio Observatory 49.92 MHz radar. The observations were performed using circular polarization on transmit and two orthogonal linear polarizations on receive, allowing scattering images to be obtained with the polarization matched to the transmitted wave (polarized), and at a polarization orthogonal to the transmitted wave (depolarized). Due to the long wavelength that penetrates efficiently into the subsurface of the Moon, the radar images are especially useful for studies of subsurface composition. Two antenna interferometry on receive was used to remove the Doppler north-south ambiguity. The images have approximately 10 km resolution in range 20 km resolution in Doppler, allowing many large scale features, including maria, terrae, and impact craters to be identified. Strong depolarized return is observed from relatively new larger impact craters with large breccia and shallow regolith. Terrae regions with less lossy surface material also appear brighter in both depolarized and polarized images. A large region in the area near the Mare Orientale impact basin has overall higher than mean radar backscatter in both polarized and depolaried returns, indicating higher than average presence of relatively newly formed large breccia in this region. Mare regions are characterized by lower polarized and depolarized return, indicating that there is higher loss of the radio wave in the subsurface, reducing the echo. We also report unexpected low polarized and depolarized backscatter from an old impact basin in the Schiller-Schickard region, as well as from the region poleward from Mare Imbrium.

Pathological proof of cellular death in radiofrequency ablation therapy and correlation with flash echo imaging--an experiment study.

PubMed

Fujiki, Kei

2004-01-01

The aims of this study were to clarify the geographic distribution of complete cell death in the radiofrequency ablated area in a porcine liver experiment, and to evaluate the efficacy of ultrasonography using contrast media in detecting the area of Radiofrequency-induced cell death. Radiofrequency ablation was performed at 3 sites in each liver in seven swine with a RF2000TM radiofrequency generator using an expandable type needle electrode. The ablation area was investigated histologically by Hematoxylin-Eosin staining and NADH staining. The area of radiofrequency-induced cell death was correlated to the ultrasonographic findings using contrast media, by means of contrast harmonic imaging, flash echo imaging-subtraction and flash echo imaging-power Doppler. The ablation area showed three distinct regions. Although the HE staining did not indicate necrosis, the NADH staining showed a complete loss of cellular activity in the inner and middle layers of the ablation area. However, in the outer layer cells displaying cellular integrity were intermingled with the necrotic cells, indicating that some of the cells in this layer had a chance to survive. Further, in some cases the outer layer of the ablated area had irregular margins. The flash-echo power-doppler images were accurately correlated in size and shape to the pathologically proved region of complete cell death in the radiofrequency-induced lesions. In the marginal part of the radiofrequency ablation area, cell death was incomplete. Flash echo imaging-power doppler was a useful and sensitive real time imaging technique for accurate evaluation of the region of complete cell death.

In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography

NASA Astrophysics Data System (ADS)

Coughlan, Carolyn A.; Chou, Li-Dek; Jing, Joseph C.; Chen, Jason J.; Rangarajan, Swathi; Chang, Theodore H.; Sharma, Giriraj K.; Cho, Kyoungrai; Lee, Donghoon; Goddard, Julie A.; Chen, Zhongping; Wong, Brian J. F.

2016-03-01

Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fiber-optic or rigid endoscopy and using stroboscopic or high-speed video to infer information about submucosal processes. Previous efforts using optical coherence tomography (OCT) have been limited by small working distances and imaging ranges. Here we report the first full field, high-speed, and long-range OCT images of awake patients’ vocal folds as well as cross-sectional video and Doppler analysis of their vocal fold motions during phonation. These vertical-cavity surface-emitting laser source (VCSEL) OCT images offer depth resolved, high-resolution, high-speed, and panoramic images of both the true and false vocal folds. This technology has the potential to revolutionize in-office imaging of the larynx.

Design and implementation of a smartphone-based portable ultrasound pulsed-wave Doppler device for blood flow measurement.

PubMed

Huang, Chih-Chung; Lee, Po-Yang; Chen, Pay-Yu; Liu, Ting-Yu

2012-01-01

Blood flow measurement using Doppler ultrasound has become a useful tool for diagnosing cardiovascular diseases and as a physiological monitor. Recently, pocket-sized ultrasound scanners have been introduced for portable diagnosis. The present paper reports the implementation of a portable ultrasound pulsed-wave (PW) Doppler flowmeter using a smartphone. A 10-MHz ultrasonic surface transducer was designed for the dynamic monitoring of blood flow velocity. The directional baseband Doppler shift signals were obtained using a portable analog circuit system. After hardware processing, the Doppler signals were fed directly to a smartphone for Doppler spectrogram analysis and display in real time. To the best of our knowledge, this is the first report of the use of this system for medical ultrasound Doppler signal processing. A Couette flow phantom, consisting of two parallel disks with a 2-mm gap, was used to evaluate and calibrate the device. Doppler spectrograms of porcine blood flow were measured using this stand-alone portable device under the pulsatile condition. Subsequently, in vivo portable system verification was performed by measuring the arterial blood flow of a rat and comparing the results with the measurement from a commercial ultrasound duplex scanner. All of the results demonstrated the potential for using a smartphone as a novel embedded system for portable medical ultrasound applications. © 2012 IEEE

Multiparametric optical coherence tomography imaging of the inner retinal hemodynamic response to visual stimulation

NASA Astrophysics Data System (ADS)

Radhakrishnan, Harsha; Srinivasan, Vivek J.

2013-08-01

The hemodynamic response to neuronal activation is a well-studied phenomenon in the brain, due to the prevalence of functional magnetic resonance imaging. The retina represents an optically accessible platform for studying lamina-specific neurovascular coupling in the central nervous system; however, due to methodological limitations, this has been challenging to date. We demonstrate techniques for the imaging of visual stimulus-evoked hyperemia in the rat inner retina using Doppler optical coherence tomography (OCT) and OCT angiography. Volumetric imaging with three-dimensional motion correction, en face flow calculation, and normalization of dynamic signal to static signal are techniques that reduce spurious changes caused by motion. We anticipate that OCT imaging of retinal functional hyperemia may yield viable biomarkers in diseases, such as diabetic retinopathy, where the neurovascular unit may be impaired.

Dynamic tissue phantoms and their use in assessment of a noninvasive optical plethysmography imaging device

NASA Astrophysics Data System (ADS)

Thatcher, Jeffrey E.; Plant, Kevin D.; King, Darlene R.; Block, Kenneth L.; Fan, Wensheng; DiMaio, J. Michael

2014-05-01

Non-contact photoplethysmography (PPG) has been studied as a method to provide low-cost and non-invasive medical imaging for a variety of near-surface pathologies and two dimensional blood oxygenation measurements. Dynamic tissue phantoms were developed to evaluate this technology in a laboratory setting. The purpose of these phantoms was to generate a tissue model with tunable parameters including: blood vessel volume change; pulse wave frequency; and optical scattering and absorption parameters. A non-contact PPG imaging system was evaluated on this model and compared against laser Doppler imaging (LDI) and a traditional pulse oximeter. Results indicate non-contact PPG accurately identifies pulse frequency and appears to identify signals from optically dense phantoms with significantly higher detection thresholds than LDI.

L wave in echo Doppler.

PubMed

Kumar, Vipin; Jose, John; Jose, V Jacob

2014-01-01

62-year-old female presented with progressive dyspnea NYHA class III for six months. Echocardiography showed normal left ventricular (LV) systolic function, mild biatrial enlargement, an L wave in pulse wave Doppler at mitral inflow and in M mode echocardiography across mitral valve. Tissue Doppler imaging at medial mitral annulus showed an L' wave in mid diastole in addition to E' and A' wave. An L wave in pulse wave Doppler and M mode echocardiography represents continued pulmonary vein mid diastolic flow through the left atrium in to LV across mitral valve after early rapid filling. Presence of an L' wave in these patients associated with higher E/E' is indicative of advance diastolic dysfunction with elevated filling pressures. Copyright © 2014 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

Ultrasonography for diagnosis, monitoring and treatment of tenosynovitis in patients with rheumatoid arthritis.

PubMed

Danielsen, Mads Ammitzbøll

2018-03-01

Rheumatod arthritis is a chronic systemic autoimmune disease, characterized by inflammation in joints and tendon sheaths, which frequently leads to permanent and serious disability due to joint destruction, but also tendon and ligament ruptures. Clinical management of rheumatoid arthritis has traditionally been supported by biochemical and radiographic findings. However, imaging modalities like ultrasound and magnetic resonance imaging (MRI) have improved the possibility for better management of rheumatoid arthritis patients, due to higher sensitivity and specificity for detecting ongoing inflammation, this thesis is focusing on tenosynovitis as recent studies have shown that inflammation in tendon sheaths, i.e. tenosynovitis, is a very common manifestation of rheumatoid arthritis and may often be mistaken for synovitis. Furthermore, presence of ultrasonographic tenosynovitis may predict clinical flare and erosive progression. 
The main aim of this PhD thesis was to further develop and validate ultrasound as a tool for diagnosis, monitoring and treatment of tenosynovitis. This was investigated in four studies: 
Study I: 3D Doppler Ultrasound findings in healthy wrist and finger tendon sheaths - Can feeding vessels lead to misinterpretation in Doppler-detected tenosynovitis? 
Study II: Image fusion of Ultrasound and MRI and B-flow evaluation of tenosynovitis - A pilot study on new imaging techniques in rheumatoid arthritis patients. 
Study III: Validity and sensitivity to change of the semi-quantitative Outcome Measures in Rheumatology Clinical Trials (OMERACT) ultrasound scoring system for tenosynovitis in patients with rheumatoid arthritis and for the quantitative scoring system, pixel index. 
Study IV: Intramuscular versus ultrasound guided intratenosynovial glucocorticoid injection for tenosynovitis in patients with rheumatoid arthritis - A randomised, double-blind, controlled study with ultrasound and clinical follow up at 4 and 12 weeks. 
From the studies presented in the PhD thesis the following was concluded:
 Doppler findings in or in close proximity to the tendon sheaths were common in wrists and fingers in healthy participants. These feeding vessels may be a source of misinterpretation, i.e .wrong diagnosis of a low degree of tenosynovitis, not only due to their presence but also because they may be interpreted as being inside the tendon sheath due to blooming and reverberations artefacts.
 Ultrasound and MRI had high agreement using image fusion for assessment of tenosynovitis when MRI partial volume artefacts were taken into account. In contrast, the agreement between B-flow and ultrasound was poor, since the quality of the b-flow images and the flow sensitivity were low.
 The OMERACT ultrasound scoring system for tenosynovitis had an excellent intra- and interreader agreement between trained investigators and a high ability to detect change over time, similarly, the quantitative tenosynovitis assessment by pixel index had a very good intrareader agreement and moderate to good interreader agreement, but only a moderate ability to detect change over time. The ultrasound scores had a high responsiveness, indicating that the OMERACT ultrasound scoring system was useful for diagnosing and monitoring tenosynovitis in rheumatoid arthritis patients in clinical trials and practice. For treatment of tenosynovitis in rheumatoid arthritis patients, remission (ultrasound tenosynovitis grey scale score ≤1 and Doppler score = 0) was achieved significantly more frequently in the ultrasound guided intratenosynovial glucocorticoid injection group than in the intramuscular glucocorticoid injection group, both at 4 and 12 week follow-ups. Furthermore, tenosynovitis responded significantly better clinically and by ultrasound assessment when treated with ultrasound guided intratenosynovial glucocorticoid injection com-pared to intramuscular glucocorticoid injection, both at 4 and 12 week follow-ups. Articles published in the Danish Medical Journal are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Data Acquisition and Processing System for Airborne Wind Profiling with a Pulsed, 2-Micron, Coherent-Detection, Doppler Lidar System

NASA Technical Reports Server (NTRS)

Beyon, J. Y.; Koch, G. J.; Kavaya, M. J.

2010-01-01

A data acquisition and signal processing system is being developed for a 2-micron airborne wind profiling coherent Doppler lidar system. This lidar, called the Doppler Aerosol Wind Lidar (DAWN), is based on a Ho:Tm:LuLiF laser transmitter and 15-cm diameter telescope. It is being packaged for flights onboard the NASA DC-8, with the first flights in the summer of 2010 in support of the NASA Genesis and Rapid Intensification Processes (GRIP) campaign for the study of hurricanes. The data acquisition and processing system is housed in a compact PCI chassis and consists of four components such as a digitizer, a digital signal processing (DSP) module, a video controller, and a serial port controller. The data acquisition and processing software (DAPS) is also being developed to control the system including real-time data analysis and display. The system detects an external 10 Hz trigger pulse and initiates the data acquisition and processing process, and displays selected wind profile parameters such as Doppler shift, power distribution, wind directions and velocities. Doppler shift created by aircraft motion is measured by an inertial navigation/GPS sensor and fed to the signal processing system for real-time removal of aircraft effects from wind measurements. A general overview of the system and the DAPS as well as the coherent Doppler lidar system is presented in this paper.

Super-resolution Doppler beam sharpening method using fast iterative adaptive approach-based spectral estimation

NASA Astrophysics Data System (ADS)

Mao, Deqing; Zhang, Yin; Zhang, Yongchao; Huang, Yulin; Yang, Jianyu

2018-01-01

Doppler beam sharpening (DBS) is a critical technology for airborne radar ground mapping in forward-squint region. In conventional DBS technology, the narrow-band Doppler filter groups formed by fast Fourier transform (FFT) method suffer from low spectral resolution and high side lobe levels. The iterative adaptive approach (IAA), based on the weighted least squares (WLS), is applied to the DBS imaging applications, forming narrower Doppler filter groups than the FFT with lower side lobe levels. Regrettably, the IAA is iterative, and requires matrix multiplication and inverse operation when forming the covariance matrix, its inverse and traversing the WLS estimate for each sampling point, resulting in a notably high computational complexity for cubic time. We propose a fast IAA (FIAA)-based super-resolution DBS imaging method, taking advantage of the rich matrix structures of the classical narrow-band filtering. First, we formulate the covariance matrix via the FFT instead of the conventional matrix multiplication operation, based on the typical Fourier structure of the steering matrix. Then, by exploiting the Gohberg-Semencul representation, the inverse of the Toeplitz covariance matrix is computed by the celebrated Levinson-Durbin (LD) and Toeplitz-vector algorithm. Finally, the FFT and fast Toeplitz-vector algorithm are further used to traverse the WLS estimates based on the data-dependent trigonometric polynomials. The method uses the Hermitian feature of the echo autocorrelation matrix R to achieve its fast solution and uses the Toeplitz structure of R to realize its fast inversion. The proposed method enjoys a lower computational complexity without performance loss compared with the conventional IAA-based super-resolution DBS imaging method. The results based on simulations and measured data verify the imaging performance and the operational efficiency.

Development of a Large Field-of-View PIV System for Rotorcraft Testing in the 14- x 22-Foot Subsonic Tunnel

NASA Technical Reports Server (NTRS)

Jenkins, Luther N.; Yao, Chung-Sheng; Bartram, Scott M.; Harris, Jerome; Allan, Brian; Wong, Oliver; Mace, W. Derry

2009-01-01

A Large Field-of-View Particle Image Velocimetry (LFPIV) system has been developed for rotor wake diagnostics in the 14-by 22-Foot Subsonic Tunnel. The system has been used to measure three components of velocity in a plane as large as 1.524 meters by 0.914 meters in both forward flight and hover tests. Overall, the system performance has exceeded design expectations in terms of accuracy and efficiency. Measurements synchronized with the rotor position during forward flight and hover tests have shown that the system is able to capture the complex interaction of the body and rotor wakes as well as basic details of the blade tip vortex at several wake ages. Measurements obtained with traditional techniques such as multi-hole pressure probes, Laser Doppler Velocimetry (LDV), and 2D Particle Image Velocimetry (PIV) show good agreement with LFPIV measurements.

Dual-Doppler Feasibility Study

NASA Technical Reports Server (NTRS)

Huddleston, Lisa L.

2012-01-01

When two or more Doppler weather radar systems are monitoring the same region, the Doppler velocities can be combined to form a three-dimensional (3-D) wind vector field thus providing for a more intuitive analysis of the wind field. A real-time display of the 3-D winds can assist forecasters in predicting the onset of convection and severe weather. The data can also be used to initialize local numerical weather prediction models. Two operational Doppler Radar systems are in the vicinity of Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS); these systems are operated by the 45th Space Wing (45 SW) and the National Weather Service Melbourne, Fla. (NWS MLB). Dual-Doppler applications were considered by the 45 SW in choosing the site for the new radar. Accordingly, the 45th Weather Squadron (45 WS), NWS MLB and the National Aeronautics and Space Administration tasked the Applied Meteorology Unit (AMU) to investigate the feasibility of establishing dual-Doppler capability using the two existing systems. This study investigated technical, hardware, and software requirements necessary to enable the establishment of a dual-Doppler capability. Review of the available literature pertaining to the dual-Doppler technique and consultation with experts revealed that the physical locations and resulting beam crossing angles of the 45 SW and NWS MLB radars make them ideally suited for a dual-Doppler capability. The dual-Doppler equations were derived to facilitate complete understanding of dual-Doppler synthesis; to determine the technical information requirements; and to determine the components of wind velocity from the equation of continuity and radial velocity data collected by the two Doppler radars. Analysis confirmed the suitability of the existing systems to provide the desired capability. In addition, it is possible that both 45 SW radar data and Terminal Doppler Weather Radar data from Orlando International Airport could be used to alleviate any radar geometry issues at the NWS MLB radar, such as the "cone of silence" or beam blockage. In the event of a radar outage at one of the sites, the multi-radar algorithms would provide continuing coverage of the area through use of the data from the remaining operational radar sites. There are several options to collect, edit, synthesize and display dual-Doppler data sets. These options include commercial packages available for purchase and a variety of freeware packages available from the National Center for Atmospheric Research (NCAR) for processing raw radar data. However, evaluation of the freeware packages revealed that they do not have sufficient documentation and configuration control to be certified for 45 SW use. Additionally, a TI data line must be installed/leased from the NWS MLB office and CCAFS to enable the receipt of NWS MLB raw radar data to use in the dual-Doppler synthesis. Integration of the TI data line into the Eastern Range infrastructure that will meet the security requirements necessary for 45 SW use is time-consuming and costly. Overall evaluation indicates that establishment of the dual-Doppler capability using the existing operational radar systems is desirable and feasible with no technical concerns. Installation of such a system represents a significant enhancement to forecasting capabilities at the 45 WS and at NWS MLB. However, data security and cost considerations must be evaluated in light of current budgetary constraints. In any case, gaining the dual-Doppler capability will provide opportunities for better visualization of the wind field and better forecasting of the onset of convection and severe weather events to support space launch operations at KSC and CCAFS.

Evaluation of a high framerate multi-exposure laser speckle contrast imaging setup

NASA Astrophysics Data System (ADS)

Hultman, Martin; Fredriksson, Ingemar; Strömberg, Tomas; Larsson, Marcus

2018-02-01

We present a first evaluation of a new multi-exposure laser speckle contrast imaging (MELSCI) system for assessing spatial variations in the microcirculatory perfusion. The MELSCI system is based on a 1000 frames per second 1-megapixel camera connected to a field programmable gate arrays (FPGA) capable of producing MELSCI data in realtime. The imaging system is evaluated against a single point laser Doppler flowmetry (LDF) system during occlusionrelease provocations of the arm in five subjects. Perfusion is calculated from MELSCI data using current state-of-the-art inverse models. The analysis displayed a good agreement between measured and modeled data, with an average error below 6%. This strongly indicates that the applied model is capable of accurately describing the MELSCI data and that the acquired data is of high quality. Comparing readings from the occlusion-release provocation showed that the MELSCI perfusion was significantly correlated (R=0.83) to the single point LDF perfusion, clearly outperforming perfusion estimations based on a single exposure time. We conclude that the MELSCI system provides blood flow images of enhanced quality, taking us one step closer to a system that accurately can monitor dynamic changes in skin perfusion over a large area in real-time.

High-Resolution Radar Imagery of Mars

NASA Astrophysics Data System (ADS)

Harmon, John K.; Nolan, M. C.

2009-09-01

We present high-resolution radar images of Mars obtained during the 2005 and 2007 oppositions. The images were constructed from long-code delay-Doppler observations made with the Arecibo S-band (13-cm) radar. The average image resolution of 3 km represented a better than order-of-magnitude improvement over pre-upgrade Arecibo imagery of the planet. Images of depolarized reflectivity (an indicator primarily of wavelength-scale surface roughness) show the same bright volcanic flow features seen in earlier imagery, but with much finer detail. A new image of the Elysium region shows fine detail in the radar-bright channels of Athabasca Vallis, Marte Vallis, and Grjota Vallis. The new images of Tharsis and Olympus Mons also show a complex array of radar-bright and radar-dark features. Southern Amazonis exhibits some of the most complex and puzzling radar-bright structure on the planet. Another curiosity is the Chryse/Xanthe/Channels region, where we find some radar-bright features in or adjacent to fluvial chaos structures. Chryse/Xanthe is also the only region of Mars showing radar-bright craters (which are rare on Mars but common on the Moon and Mercury). We also obtained the first delay-Doppler image showing the enhanced backscatter from the residual south polar ice cap. In addition to the depolarized imagery, we were able to make the first delay-Doppler images of the circular polarization ratio (an important diagnostic for surface roughness texture). We find that vast areas of the radar-bright volcanic regions have polarization ratios close to unity. Such high ratios are rare for terrestrial lava flows and only seen for extremely blocky surfaces giving high levels of multiple scattering.

High-definition flow Doppler ultrasonographic technique to assess hepatic vasculature compared with color or power Doppler ultrasonography: preliminary experience.

PubMed

Kim, Se Hyung; Lee, Jeong Min; Kim, Young Jun; Lee, Jae Young; Han, Joon Koo; Choi, Byung Ihn

2008-10-01

The purpose of this study was to introduce a new high-definition flow (HDF) Doppler technique and to compare its performance with those of color Doppler ultrasonography (CDU) and power Doppler ultrasonography (PDU) for assessment of hepatic vasculature in native and transplanted livers. High-definition flow was invented as a high-resolution bidirectional PDU technique. We obtained CDU, PDU, and HDF images of the hepatic artery (HA), portal vein (PV), and hepatic vein from 60 patients. They were divided into 2 groups: a liver transplantation group (group 1, n = 10) and a native liver group (group 2, n = 50). Two radiologists independently reviewed the cine images and graded them using a 4-point scale in terms of the clarity of the vessel margin and degree of depiction of the HA, flow filling, and flash artifacts. The degree of differentiation between the HA and PV was also evaluated. Flow directionality was recorded, and interobserver agreement was finally analyzed. Moderate to almost perfect agreement was achieved between radiologists for all parameters of each ultrasonographic technique. High-definition flow was significantly superior to both CDU and PDU with respect to all analyzed items except the degree of flash artifacts (P < .05). With regard to flash artifacts, CDU was significantly better than either PDU or HDF. High-definition flow provided directional information, as did CDU. The HDF technique provides better resolution for depicting hepatic vessels as well as their margins with less blooming compared with conventional Doppler ultrasonography in both native and transplanted liver. It also provides solid directional flow information. One point of concern, however, is the frequency of flash artifacts compared with that on CDU.

Acute testicular torsion in children: the role of sonography in the diagnostic workup.

PubMed

Gunther, P; Schenk, J P; Wunsch, R; Holland-Cunz, S; Kessler, U; Troger, J; Waag, K L

2006-11-01

Acute testicular torsion in children is an emergency and has to be diagnosed urgently. Doppler sonography is increasingly used in imaging the acute scrotum. Nevertheless, in uncertain cases, surgical exploration is required. In this study, we attempted to define the role of Doppler sonography in the diagnostic workup of the acutely painful scrotum. All patients admitted between 1999 and 2005 with acute scrotal pain were included. After clinical assessment, patients were imaged by Doppler sonography with a ''high-end'' instrument. In cases of absent arterial perfusion of the testis in Doppler sonography, surgical exploration was carried out. Patients with unaffected perfusion were followed clinically by ultrasound for up to 2 years. Sixty-one infants and children aged 1 day to 17 years (median: 7.9 years) were included. In 14 cases, sonography demonstrated absent central perfusion, with abnormal parenchymal echogenicity in six. Absence of venous blood flow together with reduction of central arterial perfusion was found in one infant. In these 15 patients, surgical exploration confirmed testicular torsion. Among the other 46 patients, we found four cases with increased testicular perfusion and 27 with increased perfusion of the epididymis. In one infant, a testicular tumour was found sonographically, and orchiectomy confirmed diagnosis of a teratoma. Follow-up examinations of the conservatively treated patients showed good clinical outcome with physiologic central perfusion as well as normal echogenic pattern of both testes. No case of testicular torsion was missed. By means of Doppler sonography, an unequivocal statement regarding testicular perfusion was possible in all cases. The initial Doppler diagnosis was confirmed by operative evaluation and follow-up ultrasound. Testicular torsion can therefore be excluded by correctly performed ultrasound with modern equipment.

MicroV Technology to Improve Transcranial Color Coded Doppler Examinations.

PubMed

Malferrari, Giovanni; Pulito, Giuseppe; Pizzini, Attilia Maria; Carraro, Nicola; Meneghetti, Giorgio; Sanzaro, Enzo; Prati, Patrizio; Siniscalchi, Antonio; Monaco, Daniela

2018-05-04

The purpose of this review is to provide an update on technology related to Transcranial Color Coded Doppler Examinations. Microvascularization (MicroV) is an emerging Power Doppler technology which can allow visualization of low and weak blood flows even at high depths, thus providing a suitable technique for transcranial ultrasound analysis. With MicroV, reconstruction of the vessel shape can be improved, without any overestimation. Furthermore, by analyzing the Doppler signal, MicroV allows a global image of the Circle of Willis. Transcranial Doppler was originally developed for the velocimetric analysis of intracranial vessels, in particular to detect stenoses and the assessment of collateral circulation. Doppler velocimetric analysis was then compared to other neuroimaging techniques, thus providing a cut-off threshold. Transcranial Color Coded Doppler sonography allowed the characterization of vessel morphology. In both Color Doppler and Power Doppler, the signal overestimated the shape of the intracranial vessels, mostly in the presence of thin vessels and high depths of study. In further neurosonology technology development efforts, attempts have been made to address morphology issues and overcome technical limitations. The use of contrast agents has helped in this regard by introducing harmonics and subtraction software, which allowed better morphological studies of vessels, due to their increased signal-to-noise ratio. Having no limitations in the learning curve, in time and contrast agent techniques, and due to its high signal-to-noise ratio, MicroV has shown great potential to obtain the best morphological definition. Copyright © 2018 by the American Society of Neuroimaging.

Previously reported sonographic appearances of regional melanoma metastases are not likely due to necrosis.

PubMed

Catalano, Orlando; Voit, Christiane; Sandomenico, Fabio; Mandato, Ylenia; Petrillo, Mario; Franco, Renato; Botti, Gerardo; Caracò, Corrado; Mozzillo, Nicola; D'Errico, Adolfo Gallipoli

2011-08-01

Sonography has proven to be a reliable tool in early detection of lymph node and in-transit cutaneous-subcutaneous metastases. Those metastases normally appear as hypoechoic or even anechoic lesions on sonography. It has been assumed that this appearance is due to necrosis of the lesions, but so far, that assumption has never been proven. The purpose of this retrospective study was to evaluate whether the hypoechoic appearance of melanoma metastasis is really due to tumor necrosis. From a radiographic database, we retrieved 212 melanoma cases imaged with sonography over a 2-year period for disease staging or follow-up. We selected 37 positive cases with 84 nodal and extranodal (satellite and in-transit) metastatic lesions and reviewed the sonograms and pathologic slides (slides available for 40 of 84 lesions). We retrospectively assessed the vascularization pattern (color Doppler images available for 78 of 84 lesions), categorizing it as poor, intermediate, or consistent. We also looked for necrosis on the histopathologic material, categorizing it into scores of 0, 1, 2, and 3 for absence of necrosis, less than 20% necrosis, 20% to 40% necrosis, and greater than 40% necrosis, respectively. Despite their gray scale appearance, most melanoma lesions were vascularized on color Doppler imaging and showed limited necrosis at histopathologic analysis. Consistent vascularization on Doppler imaging, excluding substantial necrosis, was found in 44 of 78 lesions (56.4%). Poor vascularization on Doppler imaging, suggesting necrosis, was present in only 14% of the lesions. Substantial necrosis (scores of 2 and 3) was found pathologically in only 10% of the lesions. Necrosis seems to be an uncommon event in melanoma metastasis and is probably not the basis for its low-level echo pattern on sonography. The hypoechoic appearance is very typical of melanoma metastasis and is likely due to massive melanomatous infiltration (with the poor echo reflectivity of melanin). However, confirmation in larger pathologically proven series is required.

A quantitative damage imaging technique based on enhanced CCRTM for composite plates using 2D scan

NASA Astrophysics Data System (ADS)

He, Jiaze; Yuan, Fuh-Gwo

2016-10-01

A two-dimensional (2D) non-contact areal scan system was developed to image and quantify impact damage in a composite plate using an enhanced zero-lag cross-correlation reverse-time migration (E-CCRTM) technique. The system comprises a single piezoelectric wafer mounted on the composite plate and a laser Doppler vibrometer (LDV) for scanning a region in the vicinity of the PZT to capture the scattered wavefield. The proposed damage imaging technique takes into account the amplitude, phase, geometric spreading, and all of the frequency content of the Lamb waves propagating in the plate; thus, a reflectivity coefficients of the delamination is calculated and potentially related to damage severity. Comparisons are made in terms of damage imaging quality between 2D areal scans and 1D line scans as well as between the proposed and existing imaging conditions. The experimental results show that the 2D E-CCRTM performs robustly when imaging and quantifying impact damage in large-scale composites using a single PZT actuator with a nearby areal scan using LDV.

An enhanced CCRTM (E-CCRTM) damage imaging technique using a 2D areal scan for composite plates

NASA Astrophysics Data System (ADS)

He, Jiaze; Yuan, Fuh-Gwo

2016-04-01

A two-dimensional (2-D) non-contact areal scan system was developed to image and quantify impact damage in a composite plate using an enhanced zero-lag cross-correlation reverse-time migration (E-CCRTM) technique. The system comprises a single piezoelectric actuator mounted on the composite plate and a laser Doppler vibrometer (LDV) for scanning a region to capture the scattered wavefield in the vicinity of the PZT. The proposed damage imaging technique takes into account the amplitude, phase, geometric spreading, and all of the frequency content of the Lamb waves propagating in the plate; thus, the reflectivity coefficients of the delamination can be calculated and potentially related to damage severity. Comparisons are made in terms of damage imaging quality between 2-D areal scans and linear scans as well as between the proposed and existing imaging conditions. The experimental results show that the 2-D E-CCRTM performs robustly when imaging and quantifying impact damage in large-scale composites using a single PZT actuator with a nearby areal scan using LDV.

MHD oscillations observed in the solar photosphere with the Michelson Doppler Imager

NASA Astrophysics Data System (ADS)

Norton, A.; Ulrich, R. K.; Bogart, R. S.; Bush, R. I.; Hoeksema, J. T.

Magnetohydrodynamic oscillations are observed in the solar photosphere with the Michelson Doppler Imager (MDI). Images of solar surface velocity and magnetic field strength with 4'' spatial resolution and a 60 second temporal resolution are analyzed. A two dimensional gaussian aperture with a FWHM of 10'' is applied to the data in regions of sunspot, plage and quiet sun and the resulting averaged signal is returned each minute. Significant power is observed in the magnetic field oscillations with periods of five minutes. The effect of misregistration between MDI's left circularly polarized (LCP) and right circularly polarized (RCP) images has been investigated and is found not to be the cause of the observed magnetic oscillations. It is assumed that the large amplitude acoustic waves with 5 minute periods are the driving mechanism behind the magnetic oscillations. The nature of the magnetohydrodynamic oscillations are characterized by their phase relations with simultaneously observed solar surface velocity oscillations.

Hard real-time beam scheduler enables adaptive images in multi-probe systems

NASA Astrophysics Data System (ADS)

Tobias, Richard J.

2014-03-01

Real-time embedded-system concepts were adapted to allow an imaging system to responsively control the firing of multiple probes. Large-volume, operator-independent (LVOI) imaging would increase the diagnostic utility of ultrasound. An obstacle to this innovation is the inability of current systems to drive multiple transducers dynamically. Commercial systems schedule scanning with static lists of beams to be fired and processed; here we allow an imager to adapt to changing beam schedule demands, as an intelligent response to incoming image data. An example of scheduling changes is demonstrated with a flexible duplex mode two-transducer application mimicking LVOI imaging. Embedded-system concepts allow an imager to responsively control the firing of multiple probes. Operating systems use powerful dynamic scheduling algorithms, such as fixed priority preemptive scheduling. Even real-time operating systems lack the timing constraints required for ultrasound. Particularly for Doppler modes, events must be scheduled with sub-nanosecond precision, and acquired data is useless without this requirement. A successful scheduler needs unique characteristics. To get close to what would be needed in LVOI imaging, we show two transducers scanning different parts of a subjects leg. When one transducer notices flow in a region where their scans overlap, the system reschedules the other transducer to start flow mode and alter its beams to get a view of the observed vessel and produce a flow measurement. The second transducer does this in a focused region only. This demonstrates key attributes of a successful LVOI system, such as robustness against obstructions and adaptive self-correction.

HIWRAP Radar Development for High-Altitude Operation on the NASA Global Hawk and ER-2

NASA Technical Reports Server (NTRS)

Li, Lihua; Heymsfield, Gerlad; Careswell, James; Schaubert, Dan; Creticos, Justin

2011-01-01

The NASA High-Altitude Imaging Wind and Rain Airborne Profiler (HIWRAP) is a solid-state transmitter-based, dual-frequency (Ka- and Ku-band), dual-beam (30 degree and 40 degree incidence angle), conical scan Doppler radar system, designed for operation on the NASA high-altitude (20 km) aircrafts, such as the Global Hawk Unmanned Aerial System (UAS). Supported by the NASA Instrument Incubator Program (IIP), HIWRAP was developed to provide high spatial and temporal resolution 3D wind and reflectivity data for the research of tropical cyclone and severe storms. With the simultaneous measurements at both Ku- and Ka-band two different incidence angles, HIWRAP is capable of imaging Doppler winds and volume backscattering from clouds and precipitation associated with tropical storms. In addition, HIWRAP is able to obtain ocean surface backscatter measurements for surface wind retrieval using an approach similar to QuikScat. There are three key technology advances for HIWRAP. Firstly, a compact dual-frequency, dual-beam conical scan antenna system was designed to fit the tight size and weight constraints of the aircraft platform. Secondly, The use of solid state transmitters along with a novel transmit waveform and pulse compression scheme has resulted in a system with improved performance to size, weight, and power ratios compared to typical tube based Doppler radars currently in use for clouds and precipitation measurements. Tube based radars require high voltage power supply and pressurization of the transmitter and radar front end that complicates system design and implementation. Solid state technology also significantly improves system reliability. Finally, HIWRAP technology advances also include the development of a high-speed digital receiver and processor to handle the complex receiving pulse sequences and high data rates resulting from multi receiver channels and conical scanning. This paper describes HIWRAP technology development for dual-frequency operation at high-altitudes using low peak power transmitters and pulse compression. The hardware will be described along with the methods and concepts for the system design. Finally, we will present recent preliminary results from flights on the NASA Global Hawk in support of the NASA Genesis and Rapid Intensification Processes (GRIP) field campaign, and on the NASA ER-2 as fixed nadir pointing mode for the NASA Global Precipitation Measurement (GPM) ground validation (GV) mission - Midlatitude Continental Convective Cloud Experiment (MC3E)

Ship dynamics for maritime ISAR imaging.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doerry, Armin Walter

2008-02-01

Demand is increasing for imaging ships at sea. Conventional SAR fails because the ships are usually in motion, both with a forward velocity, and other linear and angular motions that accompany sea travel. Because the target itself is moving, this becomes an Inverse- SAR, or ISAR problem. Developing useful ISAR techniques and algorithms is considerably aided by first understanding the nature and characteristics of ship motion. Consequently, a brief study of some principles of naval architecture sheds useful light on this problem. We attempt to do so here. Ship motions are analyzed for their impact on range-Doppler imaging using Inversemore » Synthetic Aperture Radar (ISAR). A framework for analysis is developed, and limitations of simple ISAR systems are discussed.« less

[Identification of cervical lymph node micrometastasis of tongue cancer by color Doppler and MRI].

PubMed

Fan, Sufeng; Zhang, Quan; Li, Qiuli; Wang, Lina; Zheng, Lie; Liu, Longzhong

2014-01-01

To assess the values of color Doppler and magnetic resonance imaging (MRI) in the identification of cervical lymph node micrometastasis of tongue cancer. Totally 96 cases of tongue cancer with impalpable neck lymph node was examined with color Doppler and MRI within one week before surgery. Chi-square test was used to assess if the presence of regional lymph node micrometastasis, histopathological analysis as a golden standard lymph node micrometastasis. For the diagnosis of cervical lymph node micrometastasis, color Doppler was significantly better than MRI in sensitivity (72.5% vs 50.0%, P = 0.039) and the accuracy (78.1% vs 64.6%, P = 0.038), but no significant difference in the specificity (82.1% vs 75.0%, P = 0.357), the positive predictive value (74.4% vs 58.8%, P = 0.159) and the negative predictive value (80.7% vs 67.7%, P = 0.108). Color Doppler is better than MRI in the sensitivity and accuracy for the diagnosis of cervical lymph node micrometastasis of tongue cancer.

Development of Rayleigh Doppler lidar for measuring middle atmosphere winds

NASA Astrophysics Data System (ADS)

Raghunath, K.; Patra, A. K.; Narayana Rao, D.

Interpretation of most of the middle and upper atmospheric dynamical and chemical data relies on the climatological description of the wind field Rayleigh Doppler lidar is one instrument which monitors wind profiles continuously though continuity is limited to clear meteorological conditions in the middle atmosphere A Doppler wind lidar operating in incoherent mode gives excellent wind and temperature information at these altitudes with necessary spectral sensitivity It observes atmospheric winds by measuring the spectral shift of the scattered light due to the motions of atmospheric molecules with background winds and temperature by spectral broadening The presentation is about the design and development of Incoherent Doppler lidar to obtain wind information in the height regions of 30-65 km The paper analyses and describes various types of techniques that can be adopted viz Edge technique and Fringe Imaging technique The paper brings out the scientific objectives configuration simulations error sources and technical challenges involved in the development of Rayleigh Doppler lidar The presentation also gives a novel technique for calibrating the lidar

Vessel packaging effect in laser speckle contrast imaging and laser Doppler imaging.

PubMed

Fredriksson, Ingemar; Larsson, Marcus

2017-10-01

Laser speckle-based techniques are frequently used to assess microcirculatory blood flow. Perfusion estimates are calculated either by analyzing the speckle fluctuations over time as in laser Doppler flowmetry (LDF), or by analyzing the speckle contrast as in laser speckle contrast imaging (LSCI). The perfusion estimates depend on the amount of blood and its speed distribution. However, the perfusion estimates are commonly given in arbitrary units as they are nonlinear and depend on the magnitude and the spatial distribution of the optical properties in the tissue under investigation. We describe how the spatial confinement of blood to vessels, called the vessel packaging effect, can be modeled in LDF and LSCI, which affect the Doppler power spectra and speckle contrast, and the underlying bio-optical mechanisms for these effects. As an example, the perfusion estimate is reduced by 25% for LDF and often more than 50% for LSCI when blood is located in vessels with an average diameter of 40  μm, instead of being homogeneously distributed within the tissue. This significant effect can be compensated for only with knowledge of the average diameter of the vessels in the tissue. (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

Evaluation of hemodynamics changes during interventional stent placement using Doppler optical coherence tomography

NASA Astrophysics Data System (ADS)

Vuong, Barry; Genis, Helen; Wong, Ronnie; Ramjist, Joel; Jivraj, Jamil; Farooq, Hamza; Sun, Cuiru; Yang, Victor X. D.

2015-03-01

Carotid atherosclerosis is a critical medical concern that can lead to ischemic stroke. Local hemodynamic patterns have also been associated with the development of atherosclerosis, particularly in regions with disturbed flow patterns such as bifurcations. Traditionally, this disease was treated using carotid endarterectomy, however recently there is an increasing trend of carotid artery stenting due to its minimally invasive nature. It is well known that this interventional technique creates changes in vasculature geometry and hemodynamic patterns due to the interaction of stent struts with arterial lumen, and is associated with complications such as distal emboli and restenosis. Currently, there is no standard imaging technique to evaluate regional hemodynamic patterns found in stented vessels. Doppler optical coherence tomography (DOCT) provides an opportunity to identify in vivo hemodynamic changes in vasculature using high-resolution imaging. In this study, blood flow profiles were examined at the bifurcation junction in the internal carotid artery (ICA) in a porcine model following stent deployment. Doppler imaging was further conducted using pulsatile flow in a phantom model, and then compared to computational fluid dynamics (CFD) simulation of a virtual bifurcation to assist with the interpretation of emphin vivo results.

Verification of large-scale rapid transport in the lower thermosphere: Tracking the exhaust plume of STS-107 from launch to the Antarctic

NASA Astrophysics Data System (ADS)

Niciejewski, R.; Skinner, W.; Cooper, M.; Marshall, A.; Meier, R. R.; Stevens, M. H.; Ortland, D.; Wu, Q.

2011-05-01

New analysis of the Doppler shift of O2 airglow spectra recorded by the TIMED Doppler Interferometer (TIDI) and the High Resolution Doppler Imager (HRDI) have provided conclusive evidence that the shuttle main engine exhaust plume generated in the lower thermosphere by the launch of STS-107 and imaged by the Global Ultraviolet Imager (GUVI) instrument on TIMED was transported to the Antarctic in ˜80 h, supporting a key inference from the initial study by Stevens et al. (2005). These new results were aided by improved knowledge of the effects of instrumental and satellite artifacts imposed on the Doppler spectra. STS-107 launched on 16 January 2003, and the neutral wind near its launch trajectory and nearby volume was sampled within minutes by TIDI. These initial observations suggested that the northernmost end of the shuttle's exhaust plume would move northeast and that the southern end would move southeast, motions that were identified in imagery acquired during the next orbit of TIMED. The direction and magnitude of plume motion inferred from GUVI images obtained 12, 26, and 50 h after launch were again confirmed by TIDI and HRDI. The appearance of the plume over the Antarctic ˜80 h after launch, inferred from earlier work by the appearance of iron ablated from the shuttle's main engines, was consistent with neutral winds measured by the satellite Doppler instruments over the Antarctic. The transport of the plume from the coast of Florida to the Antarctic was aided by the favorable phase and strong amplitude of a 2 day planetary wave of wave number three in the southern hemisphere on 18 January 2003. The existence of the 2 day wave was deduced from zonally averaged and combined TIDI and HRDI neutral wind observations. We conclude that the existence of strong and sustained winds in the MLT, significantly greater than expected from empirical and theoretical models, is indisputable and provides compelling evidence supporting the global-scale nature of thermospheric winds with magnitude greater than 100 m/s observed by Larsen (2002) from 40 years of sounding rocket chemical release experiments.

A 29-year-old Harken disk mitral valve: long-term follow-up by echocardiographic and cineradiographic imaging.

PubMed

Hsi, David H; Ryan, Gerald F; Taft, Janice; Arnone, Thomas J

2003-01-01

An 81-year-old woman was evaluated for prosthetic mitral valve function. She had received a Harken disk mitral valve 29 years earlier due to severe mitral valve disease. This particular valve prosthesis is known for premature disk edge wear and erosion. The patients 2-dimensional Doppler echocardiogram showed the distinctive appearance of a disk mitral valve prosthesis. Color Doppler in diastole showed a unique crown appearance, with initial flow acceleration around the disk followed by convergence to laminar flow in the left ventricle. Cineradiographic imaging revealed normal valve function and minimal disk erosion. We believe this to be the longest reported follow-up of a surviving patient with a rare Harken disk valve. We present images with unique echocardiographic and cineangiographic features.

Structural and functional optical coherence tomography imaging of the colon

NASA Astrophysics Data System (ADS)

Welge, Weston Anthony

Colorectal cancer (CRC) remains the second deadliest cancer in the United States, despite steady reduction in mortality rate over the last three decades. Colonoscopy is the gold-standard screening modality with high sensitivity and specificity to mature polyps. However, the miss rate for small (< 5 mm) lesions is estimated to be as high as 26%. Because the five-year survival rate for CRC detected at the local stage is 90%, there is a clear need for a screening procedure that is sensitive to these small lesions. Optical coherence tomography (OCT) has become a major biomedical imaging modality since its invention in 1991. As the optical analog to ultrasound, OCT provides information in both lateral and depth dimensions with resolution < 10 ?m and an imaging depth of about 1.5 mm in scattering tissue. In this dissertation, I describe my efforts to develop new uses of OCT for improved early detection of adenoma in the azoxymethane mouse model of CRC. In recent years, commercial OCT systems have reached imaging speeds sufficiently high for in vivo volumeric imaging while laterally sampling the tissue at the Nyquist limit. First, I describe the design of a miniature endoscope and the integration of this probe with a commercial OCT system. Then I describe the development of two OCT imaging methods, one structural and one functional, that could be used for future work in diagnostic or therapeutic studies. The structural method produces en face images of the colon surface showing the colonic crypts, the first such demonstration of crypt visualization in the mouse. Changes in the crypt pattern are correlated with adenoma and are one of the earliest morphological changes. The functional method uses a Doppler OCT algorithm and image processing to detect the colon microvasculature. This technique can be used for vessel counting and blood flow measurements. Angiogenesis occurs at the beginning of tumorigenesis, and the tumor-originated arterioles are incapable of regular vasodilation. This Doppler OCT technique could potentially detect tumors at the earliest stages by measuring the change in local blood flow velocity in response to vasodilatory stimuli.

Doppler Acoustic Vortex Sensing System

DOT National Transportation Integrated Search

1978-10-01

This is the final report on the Doppler Acoustic Vortex Sensing System, (DAVSS) program carried out by Avco Corporation's Systems Division for the U.S. Department of Transportation, Transportation Systems Center. The objective of the program was the ...

Synchronized epiaortic two-dimensional and color Doppler echocardiographic guidance enables routine ascending aortic cannulation in type A acute aortic dissection.

PubMed

Inoue, Yoshito; Takahashi, Ryuichi; Ueda, Toshihiko; Yozu, Ryohei

2011-02-01

Preference for arterial inflow during surgery for type A acute aortic dissection remains controversial. Antegrade central perfusion prevents malperfusion and retrograde embolism, and the ascending aorta provides arterial access for rapid establishment of systemic perfusion, especially if there is hemodynamic instability. It has not been used routinely, however, because of the disruption caused to the aorta. We evaluated the safety and efficacy of routine cannulation of the dissected aorta for the repair of type A dissection. Surgical results were analyzed for 83 consecutive patients with type A acute aortic dissection between 2002 and 2009. They were treated surgically by prosthetic graft replacement under hypothermic circulatory arrest. The ascending aorta was routinely cannulated using the Seldinger technique with epiaortic echocardiographic guidance; antegrade systemic perfusion was evaluated by color Doppler ultrasound. Systemic antegrade perfusion via the dissected ascending aorta was performed safely in all cases. There was no malperfusion or thromboembolism as a result of ascending aortic cannulation. Epiaortic 2-dimensional and color Doppler imaging provided real-time monitoring adequate for the placement and for proper systemic perfusion. There were 5 in-hospital deaths (5/83=6.0%) and 8 strokes (preoperative 6/83=7.2%, postoperative 2/83=2.4%). A total of 78 patients (78/83=94%) were discharged and have been followed up without major adverse cardiac events for a mean duration of 31.8 months. Ascending aortic cannulation is a simple and safe technique that provides a rapid and reliable route of antegrade central systemic perfusion in type A aortic dissection. Copyright © 2011 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

Three dimensional laser Doppler velocimeter turbulence measurements in a pipe flow

NASA Technical Reports Server (NTRS)

Fuller, C. E., III; Cliff, W. C.; Huffaker, R. M.

1973-01-01

The mean and turbulent u, v, and w components of a gaseous fully developed turbulent pipe flow were measured with a laser Doppler velocimeter system. Measurements of important system parameters are presented and discussed in relation to the measurement accuracy. Simultaneous comparisons of the laser Doppler and hot wire anemometer measurements in the turbulent flow provided evidence that the two systems were responding to the same flow phenomena.

High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging

NASA Astrophysics Data System (ADS)

Chen, Wei; You, Jiang; Gu, Xiaochun; Du, Congwu; Pan, Yingtian

2016-12-01

Noninvasive microvascular imaging using optical coherence Doppler tomography (ODT) has shown great promise in brain studies; however, high-speed microcirculatory imaging in deep brain remains an open quest. A high-speed 1.3 μm swept-source ODT (SS-ODT) system is reported which was based on a 200 kHz vertical-cavity-surface-emitting laser. Phase errors induced by sweep-trigger desynchronization were effectively reduced by spectral phase encoding and instantaneous correlation among the A-scans. Phantom studies have revealed a significant reduction in phase noise, thus an enhancement of minimally detectable flow down to 268.2 μm/s. Further in vivo validation was performed, in which 3D cerebral-blood-flow (CBF) networks in mouse brain over a large field-of-view (FOV: 8.5 × 5 × 3.2 mm3) was scanned through thinned skull. Results showed that fast flows up to 3 cm/s in pial vessels and minute flows down to 0.3 mm/s in arterioles or venules were readily detectable at depths down to 3.2 mm. Moreover, the dynamic changes of the CBF networks elicited by acute cocaine such as heterogeneous responses in various vessel compartments and at different cortical layers as well as transient ischemic events were tracked, suggesting the potential of SS-ODT for brain functional imaging that requires high flow sensitivity and dynamic range, fast frame rate and a large FOV to cover different brain regions.

Stokes-Doppler coherence imaging for ITER boundary tomography.

PubMed

Howard, J; Kocan, M; Lisgo, S; Reichle, R

2016-11-01

An optical coherence imaging system is presently being designed for impurity transport studies and other applications on ITER. The wide variation in magnetic field strength and pitch angle (assumed known) across the field of view generates additional Zeeman-polarization-weighting information that can improve the reliability of tomographic reconstructions. Because background reflected light will be somewhat depolarized analysis of only the polarized fraction may be enough to provide a level of background suppression. We present the principles behind these ideas and some simulations that demonstrate how the approach might work on ITER. The views and opinions expressed herein do not necessarily reflect those of the ITER Organization.

Amalthea's density is less than that of water.

PubMed

Anderson, John D; Johnson, Torrence V; Schubert, Gerald; Asmar, Sami; Jacobson, Robert A; Johnston, Douglas; Lau, Eunice L; Lewis, George; Moore, William B; Taylor, Anthony; Thomas, Peter C; Weinwurm, Gudrun

2005-05-27

Radio Doppler data from the Galileo spacecraft's encounter with Amalthea, one of Jupiter's small inner moons, on 5 November 2002 yield a mass of (2.08 +/- 0.15) x 10(18) kilograms. Images of Amalthea from two Voyager spacecraft in 1979 and Galileo imaging between November 1996 and June 1997 yield a volume of (2.43 +/- 0.22) x 10(6) cubic kilometers. The satellite thus has a density of 857 +/- 99 kilograms per cubic meter. We suggest that Amalthea is porous and composed of water ice, as well as rocky material, and thus formed in a cold region of the solar system, possibly not at its present location near Jupiter.

Amalthea's density is less than that of water

NASA Technical Reports Server (NTRS)

Anderson, John D.; Johnson, Torrence V.; Schubert, Gerald; Asmar, Sami; Jacobson, Robert A.; Johnston, Douglas; Lau, Eunice L.; Lewis, George; Moore, William B.; Taylor, Anthony;

Polarimetric Radar images of the Moon at 6-meter Wavelength

NASA Astrophysics Data System (ADS)

Vierinen, J.

2017-12-01

We present new range-Doppler images of the Moon using 6-meterwavelength. The radar images were obtained using the Jicamarca RadioObservatory 49.92 MHz radar. The observations were performed usingcircular polarization on transmit and two orthogonal linearpolarizations on receive, allowing scattering images to be obtainedwith the polarization matched to the transmitted wave (polarized), andat a polarization orthogonal to the transmitted wave (depolarized).Due to the long wavelength that penetrates efficiently into thesubsurface of the Moon, the radar images are especially useful forstudies of subsurface composition. Two antenna interferometry onreceive was used to remove the Doppler north-south ambiguity. Theimages have approximately 10 km resolution in range 20 km resolutionin Doppler, allowing many large scale features, including maria,terrae, and impact craters to be identified. Strong depolarized returnis observed from relatively new larger impact craters with largebreccia and shallow regolith. Terrae regions with less lossy surfacematerial also appear brighter in both depolarized and polarizedimages. A large region in the area near the Mare Orientale impactbasin has overall higher than mean radar backscatter in both polarizedand depolaried returns, indicating higher than average presence ofrelatively newly formed large breccia in this region. Mare regions arecharacterized by lower polarized and depolarized return, indicatingthat there is higher loss of the radio wave in the subsurface,reducing the echo. We also report unexpected low polarized anddepolarized backscatter from an old impact basin in theSchiller-Schickard region, as well as from the region poleward fromMare Imbrium.

Quantitative power Doppler ultrasound measures of peripheral joint synovitis in poor prognosis early rheumatoid arthritis predict radiographic progression.

PubMed

Sreerangaiah, Dee; Grayer, Michael; Fisher, Benjamin A; Ho, Meilien; Abraham, Sonya; Taylor, Peter C

2016-01-01

To assess the value of quantitative vascular imaging by power Doppler US (PDUS) as a tool that can be used to stratify patient risk of joint damage in early seropositive RA while still biologic naive but on synthetic DMARD treatment. Eighty-five patients with seropositive RA of <3 years duration had clinical, laboratory and imaging assessments at 0 and 12 months. Imaging assessments consisted of radiographs of the hands and feet, two-dimensional (2D) high-frequency and PDUS imaging of 10 MCP joints that were scored for erosions and vascularity and three-dimensional (3D) PDUS of MCP joints and wrists that were scored for vascularity. Severe deterioration on radiographs and ultrasonography was seen in 45 and 28% of patients, respectively. The 3D power Doppler volume and 2D vascularity scores were the most useful US predictors of deterioration. These variables were modelled in two equations that estimate structural damage over 12 months. The equations had a sensitivity of 63.2% and specificity of 80.9% for predicting radiographic structural damage and a sensitivity of 54.2% and specificity of 96.7% for predicting structural damage on ultrasonography. In seropositive early RA, quantitative vascular imaging by PDUS has clinical utility in predicting which patients will derive benefit from early use of biologic therapy. © The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Evaluation of portal venous velocity with Doppler ultrasound in patients with nonalcoholic fatty liver disease.

PubMed

Ulusan, Serife; Yakar, Tolga; Koc, Zafer

2011-01-01

We examined the relationship between portal venous velocity and hepatic-abdominal fat in patients with nonalcoholic fatty liver disease (NAFLD), using spectral Doppler ultrasonography (US) and magnetic resonance imaging (MRI). In this prospective study, 35 patients with NAFLD and 29 normal healthy adults (control group) underwent portal Doppler US. The severity of hepatic steatosis in patients with NAFLD was assessed by MRI through chemical shift imaging, using a modification of the Dixon method. Abdominal (intra-abdominal and subcutaneous) fat was measured by MRI. The difference in portal venous velocity between the patients with NAFLD and the control group was significant (p < 0.0001). There was no correlation between the degree of abdominal or hepatic fat and portal venous velocity (p > 0.05). There were strong correlations between the hepatic fat fraction and subcutaneous adiposity (p < 0.0001), intraperitoneal fat accumulation (p = 0.017), and retroperitoneal fat accumulation (p < 0.0001). Our findings suggest that patients with NAFLD have lower portal venous velocities than normal healthy subjects.

Fully distributed absolute blood flow velocity measurement for middle cerebral arteries using Doppler optical coherence tomography

PubMed Central

Qi, Li; Zhu, Jiang; Hancock, Aneeka M.; Dai, Cuixia; Zhang, Xuping; Frostig, Ron D.; Chen, Zhongping

2016-01-01

Doppler optical coherence tomography (DOCT) is considered one of the most promising functional imaging modalities for neuro biology research and has demonstrated the ability to quantify cerebral blood flow velocity at a high accuracy. However, the measurement of total absolute blood flow velocity (BFV) of major cerebral arteries is still a difficult problem since it is related to vessel geometry. In this paper, we present a volumetric vessel reconstruction approach that is capable of measuring the absolute BFV distributed along the entire middle cerebral artery (MCA) within a large field-of-view. The Doppler angle at each point of the MCA, representing the vessel geometry, is derived analytically by localizing the artery from pure DOCT images through vessel segmentation and skeletonization. Our approach could achieve automatic quantification of the fully distributed absolute BFV across different vessel branches. Experiments on rodents using swept-source optical coherence tomography showed that our approach was able to reveal the consequences of permanent MCA occlusion with absolute BFV measurement. PMID:26977365

Fully distributed absolute blood flow velocity measurement for middle cerebral arteries using Doppler optical coherence tomography.

PubMed

Qi, Li; Zhu, Jiang; Hancock, Aneeka M; Dai, Cuixia; Zhang, Xuping; Frostig, Ron D; Chen, Zhongping

2016-02-01

Doppler optical coherence tomography (DOCT) is considered one of the most promising functional imaging modalities for neuro biology research and has demonstrated the ability to quantify cerebral blood flow velocity at a high accuracy. However, the measurement of total absolute blood flow velocity (BFV) of major cerebral arteries is still a difficult problem since it is related to vessel geometry. In this paper, we present a volumetric vessel reconstruction approach that is capable of measuring the absolute BFV distributed along the entire middle cerebral artery (MCA) within a large field-of-view. The Doppler angle at each point of the MCA, representing the vessel geometry, is derived analytically by localizing the artery from pure DOCT images through vessel segmentation and skeletonization. Our approach could achieve automatic quantification of the fully distributed absolute BFV across different vessel branches. Experiments on rodents using swept-source optical coherence tomography showed that our approach was able to reveal the consequences of permanent MCA occlusion with absolute BFV measurement.

Non-contact and noise tolerant heart rate monitoring using microwave doppler sensor and range imagery.

PubMed

Matsunag, Daichi; Izumi, Shintaro; Okuno, Keisuke; Kawaguchi, Hiroshi; Yoshimoto, Masahiko

2015-01-01

This paper describes a non-contact and noise-tolerant heart beat monitoring system. The proposed system comprises a microwave Doppler sensor and range imagery using Microsoft Kinect™. The possible application of the proposed system is a driver health monitoring. We introduce the sensor fusion approach to minimize the heart beat detection error. The proposed algorithm can subtract a body motion artifact from Doppler sensor output using time-frequency analysis. The body motion artifact is a crucially important problem for biosignal monitoring using microwave Doppler sensor. The body motion speed is obtainable from range imagery, which has 5-mm resolution at 30-cm distance. Measurement results show that the success rate of the heart beat detection is improved about 75% on average when the Doppler wave is degraded by the body motion artifact.

A model for gravity-wave spectra observed by Doppler sounding systems

NASA Technical Reports Server (NTRS)

Vanzandt, T. E.

1986-01-01

A model for Mesosphere - Stratosphere - Troposphere (MST) radar spectra is developed following the formalism presented by Pinkel (1981). Expressions for the one-dimensional spectra of radial velocity versus frequency and versus radial wave number are presented. Their dependence on the parameters of the gravity-wave spectrum and on the experimental parameters, radar zenith angle and averaging time are described and the conditions for critical tests of the gravity-wave hypothesis are discussed. The model spectra is compared with spectra observed in the Arctic summer mesosphere by the Poker Flat radar. This model applies to any monostatic Doppler sounding system, including MST radar, Doppler lidar and Doppler sonar in the atmosphere, and Doppler sonar in the ocean.

[Venous Doppler color echography: importance and inconveniences].

PubMed

Laroche, J P; Dauzat, M; Muller, G; Janbon, C

1993-01-01

Color Doppler is a technique which performs a real-time opacification of the vascular system with blue indicating reverse flow and red indicating forward flow (directional color coding). In venous pathology, the use of color Doppler improves significantly the anatomical evaluation of the inferior vena cava, the iliac vein, the deep femoral vein, and the sural system. Color Doppler facilitates the study of deep venous thrombosis (providing useful information to differentiate ancient from most recent thrombus) and also the study of post-thrombotic conditions (assessment of reverse flow, repermeation phenomena). Finally, color Doppler produces a better insight for the study of varicose veins, especially with regard to mapping, identification of communicante veins, and study of the external saphenous vein.

A novel approach for quantification and analysis of the color Doppler twinkling artifact with application in noninvasive surface roughness characterization: an in vitro phantom study.

PubMed

Jamzad, Amoon; Setarehdan, Seyed Kamaledin

2014-04-01

The twinkling artifact is an undesired phenomenon within color Doppler sonograms that usually appears at the site of internal calcifications. Since the appearance of the twinkling artifact is correlated with the roughness of the calculi, noninvasive roughness estimation of the internal stones may be considered as a potential twinkling artifact application. This article proposes a novel quantitative approach for measurement and analysis of twinkling artifact data for roughness estimation. A phantom was developed with 7 quantified levels of roughness. The Doppler system was initially calibrated by the proposed procedure to facilitate the analysis. A total of 1050 twinkling artifact images were acquired from the phantom, and 32 novel numerical measures were introduced and computed for each image. The measures were then ranked on the basis of roughness quantification ability using different methods. The performance of the proposed twinkling artifact-based surface roughness quantification method was finally investigated for different combinations of features and classifiers. Eleven features were shown to be the most efficient numerical twinkling artifact measures in roughness characterization. The linear classifier outperformed other methods for twinkling artifact classification. The pixel count measures produced better results among the other categories. The sequential selection method showed higher accuracy than other individual rankings. The best roughness recognition average accuracy of 98.33% was obtained by the first 5 principle components and the linear classifier. The proposed twinkling artifact analysis method could recognize the phantom surface roughness with average accuracy of 98.33%. This method may also be applicable for noninvasive calculi characterization in treatment management.

Effect of scanline orientation on ventricular flow propagation: assessment using high frame-rate color Doppler echocardiography

NASA Technical Reports Server (NTRS)

Greenberg, N. L.; Castro, P. L.; Drinko, J.; Garcia, M. J.; Thomas, J. D.

2000-01-01

Color M-mode echocardiography has recently been utilized to describe diastolic flow propagation velocity (Vp) in the left ventricle. While increasing temporal resolution from 15 to 200 Hz, this M-mode technique requires the user to select a single scanline, potentially limiting quantification of Vp due to the complex three-dimensional inflow pattern. We previously performed computational fluid dynamics simulations to demonstrate the insignificance of the scanline orientation, however geometric complexity was limited. The purpose of this study was to utilize high frame-rate 2D color Doppler images to investigate the importance of scanline selection in patients for the quantification of Vp. 2D color Doppler images were digitally acquired at 50 frames/s in 6 subjects from the apical 4-chamber window (System 5, GE/Vingmed, Milwaukee, WI). Vp was determined for a set of scanlines positioned through 5 locations across the mitral annulus (from the anterior to posterior mitral annulus). An analysis of variance was performed to examine the differences in Vp as a function of scanline position. Vp was not effected by scanline position in sampled locations from the center of the mitral valve towards the posterior annulus. Although not statistically significant, there was a trend to slower propagation velocities on the anterior side of the valve (60.8 +/- 16.7 vs. 54.4 +/- 13.6 cm/s). This study clinically validates our previous numerical experiment showing that Vp is insensitive to small perturbations of the scanline through the mitral valve. However, further investigation is necessary to examine the impact of ventricular geometry in pathologies including dilated cardiomyopathy.

Loss of echogenicity and onset of cavitation from echogenic liposomes: pulse repetition frequency independence

PubMed Central

Radhakrishnan, Kirthi; Haworth, Kevin J; Peng, Tao; McPherson, David D.; Holland, Christy K.

2014-01-01

Echogenic liposomes (ELIP) are being developed for the early detection and treatment of atherosclerotic lesions. An 80% loss of echogenicity of ELIP (Radhakrishnan et al. 2013) has been shown to be concomitant with the onset of stable and inertial cavitation. The ultrasound pressure amplitude at which this occurs is weakly dependent on pulse duration. Smith et al. (2007) have reported that the rapid fragmentation threshold of ELIP (based on changes in echogenicity) is dependent on the insonation pulse repetition frequency (PRF). The current study evaluates the relationship between loss of echogenicity and cavitation emissions from ELIP insonified by duplex Doppler pulses at four PRFs (1.25 kHz, 2.5 kHz, 5 kHz, and 8.33 kHz). Loss of echogenicity was evaluated on B-mode images of ELIP. Cavitation emissions from ELIP were recorded passively on a focused single-element transducer and a linear array. Emissions recorded by the linear array were beamformed and the spatial widths of stable and inertial cavitation emissions were compared to the calibrated azimuthal beamwidth of the Doppler pulse exceeding the stable and inertial cavitation thresholds. The inertial cavitation thresholds had a very weak dependence on PRF and stable cavitation thresholds were independent of PRF. The spatial widths of the cavitation emissions recorded by the passive cavitation imaging system agreed with the calibrated Doppler beamwidths. The results also show that 64%–79% loss of echogenicity can be used to classify the presence or absence of cavitation emissions with greater than 80% accuracy. PMID:25438849

Loss of echogenicity and onset of cavitation from echogenic liposomes: pulse repetition frequency independence.

PubMed

Radhakrishnan, Kirthi; Haworth, Kevin J; Peng, Tao; McPherson, David D; Holland, Christy K

2015-01-01

Echogenic liposomes (ELIP) are being developed for the early detection and treatment of atherosclerotic lesions. An 80% loss of echogenicity of ELIP has been found to be concomitant with the onset of stable and inertial cavitation. The ultrasound pressure amplitude at which this occurs is weakly dependent on pulse duration. It has been reported that the rapid fragmentation threshold of ELIP (based on changes in echogenicity) is dependent on the insonation pulse repetition frequency (PRF). The study described here evaluates the relationship between loss of echogenicity and cavitation emissions from ELIP insonified by duplex Doppler pulses at four PRFs (1.25, 2.5, 5 and 8.33 kHz). Loss of echogenicity was evaluated on B-mode images of ELIP. Cavitation emissions from ELIP were recorded passively on a focused single-element transducer and a linear array. Emissions recorded by the linear array were beamformed, and the spatial widths of stable and inertial cavitation emissions were compared with the calibrated azimuthal beamwidth of the Doppler pulse exceeding the stable and inertial cavitation thresholds. The inertial cavitation thresholds had a very weak dependence on PRF, and stable cavitation thresholds were independent of PRF. The spatial widths of the cavitation emissions recorded by the passive cavitation imaging system agreed with the calibrated Doppler beamwidths. The results also indicate that 64%-79% loss of echogenicity can be used to classify the presence or absence of cavitation emissions with greater than 80% accuracy. Copyright © 2015 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

Apparatus for the analysis of surfaces in gas environments using Positron Spectroscopy

NASA Astrophysics Data System (ADS)

Satyal, Suman; Lim, Lawrence; Joglekar, Vibek; Kalaskar, Sushant; Shastry, Karthik; Weiss, Alex

2010-10-01

Positron spectroscopy performed with low energy beams can provide highly surface specific information due to the trapping of positrons in an image potential surface state at the time of annihilation. Here we describe a spectrometer that will employ differential pumping to enable us to transport the positrons most of the way from the source to the sample under high vacuum and then to traverse a thin gas layer surrounding the sample. The positrons will be implanted into the sample at energies less than ˜10 keV ensuring that a large fraction will diffuse back to the surface before annihilation. The Elemental content of the surface interacting with the gas environment will then be determined from the Doppler broadened gamma spectra. This system will include a time of flight positron annihilation induced Auger spectrometer (TOF-PAES) which correlates with the Doppler measurements at lower pressures.

Diagnostic ultrasound imaging for lateral epicondylalgia: a case-control study.

PubMed

Heales, Luke James; Broadhurst, Nathan; Mellor, Rebecca; Hodges, Paul William; Vicenzino, Bill

2014-11-01

Lateral epicondylalgia (LE) is clinically diagnosed as pain over the lateral elbow that is provoked by gripping. Usually, LE responds well to conservative intervention; however, those who fail such treatment require further evaluation, including musculoskeletal ultrasound. Previous studies of musculoskeletal ultrasound have methodological flaws, such as lack of assessor blinding and failure to control for participant age, sex, and arm dominance. The purpose of this study was to assess the diagnostic use of blinded ultrasound imaging in people with clinically diagnosed LE compared with that in a control group matched for age, sex, and arm dominance. Participants (30 with LE and 30 controls) underwent clinical examination as the criterion standard test. Unilateral LE was defined as pain over the lateral epicondyle, which was provoked by palpation, resisted wrist and finger extension, and gripping. Controls without symptoms were matched for age, sex, and arm dominance. Ultrasound investigations were performed by two sonographers using a standardized protocol. Grayscale images were assessed for signs of tendon pathology and rated on a four-point ordinal scale. Power Doppler was used to assess neovascularity and rated on a five-point ordinal scale. The combination of grayscale and power Doppler imaging revealed an overall sensitivity of 90% and specificity of 47%. The positive and negative likelihood ratios for combined grayscale and power Doppler imaging were 1.69 and 0.21, respectively. Although ultrasound imaging helps confirm the absence of LE, when findings are negative for tendinopathic changes, the high prevalence of tendinopathic changes in pain-free controls challenges the specificity of the measure. The validity of ultrasound imaging to confirm tendon pathology in clinically diagnosed LE requires further study with strong methodology.

Coherence imaging for ion temperature and flow measurements in a low-temperature helicon plasma source

NASA Astrophysics Data System (ADS)

Lester, R.; Zhai, Y.; Corr, C.; Howard, J.

2016-02-01

This paper describes a coherence imaging system designed for spectroscopic Doppler measurements of ion light in a low-temperature (T e   <  10 eV) helicon-produced argon plasma. Observation of the very small Doppler broadening of the Ar II 488 nm emission line requires very high spectral resolution, or equivalently, very large interferometric optical path delay (comparable with the coherence length of the emission line). For these polarization interferometers, this can only be achieved using large thicknesses (100 mm) of birefringent crystal. This poses special design challenges including the application of field-widening techniques and the development of passive thermal stabilization of the optical phase offset. We discuss the measurement principles and the optical design of these systems and present measurements of the line-integrated emissivity, and ion flow and ion temperatures along with tomographic reconstructions of the local values, for a cylindrical low temperature helicon discharge in a linear magnetized device with downstream magnetic mirror. Key results reveal a hollow edge-peaked temperature profile (central temperature  ∼0.1 eV) and sheared rigid-body rotational flows and axial flows which are comparable with the ion thermal speed. The emission line brightness, ion temperature and azimuthal ion flows are all found to increase with increased mirror magnetic field strength.

Skin perfusion evaluation between laser speckle contrast imaging and laser Doppler flowmetry

NASA Astrophysics Data System (ADS)

Humeau-Heurtier, Anne; Mahe, Guillaume; Durand, Sylvain; Abraham, Pierre

2013-03-01

In the biomedical field, laser Doppler flowmetry (LDF) and laser speckle contrast imaging (LSCI) are two optical techniques aiming at monitoring - non-invasively - the microvascular blood perfusion. LDF has been used for nearly 40 years whereas LSCI is a recent technique that overcomes some drawbacks of LDF. Both LDF and LSCI give perfusion assessments in arbitrary units. However, the possible relationship existing between perfusions given by LDF and by LSCI over large blood flow values has not been completely studied yet. We therefore herein evaluate the relationship between the LDF and LSCI perfusion values across a broad range of skin blood flows. For this purpose, LDF and LSCI data were acquired simultaneously on the forearm of 12 healthy subjects, at rest, during different durations of vascular occlusion and during reactive hyperemia. For the range of skin blood flows studied, the power function fits the data better than the linear function: powers for individual subjects go from 1.2 to 1.7 and the power is close to 1.3 when all the subjects are studied together. We thus suggest distinguishing perfusion values given by the two optical systems.

Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography

NASA Astrophysics Data System (ADS)

Huang, Yong; Tong, Dedi; Zhu, Shan; Wu, Lehao; Ibrahim, Zuhaib; Lee, WP Andrew; Brandacher, Gerald; Kang, Jin U.

2014-03-01

Vascular and microvascular anastomosis are critical components of reconstructive microsurgery, vascular surgery and transplant surgery. Imaging modality that provides immediate, real-time in-depth view and 3D structure and flow information of the surgical site can be a great valuable tool for the surgeon to evaluate surgical outcome following both conventional and innovative anastomosis techniques, thus potentially increase the surgical success rate. Microvascular anastomosis for vessels with outer diameter smaller than 1.0 mm is extremely challenging and effective evaluation of the outcome is very difficult if not impossible using computed tomography (CT) angiograms, magnetic resonance (MR) angiograms and ultrasound Doppler. Optical coherence tomography (OCT) is a non-invasive high-resolution (micron level), high-speed, 3D imaging modality that has been adopted widely in biomedical and clinical applications. Phaseresolved Doppler OCT that explores the phase information of OCT signals has been shown to be capable of characterizing dynamic blood flow clinically. In this work, we explore the capability of Fourier domain Doppler OCT as an evaluation tool to detect commonly encountered post-operative complications that will cause surgical failure and to confirm positive result with surgeon's observation. Both suture and cuff based techniques were evaluated on the femoral artery and vein in the rodent model.

2D Doppler backscattering using synthetic aperture microwave imaging of MAST edge plasmas

NASA Astrophysics Data System (ADS)

Thomas, D. A.; Brunner, K. J.; Freethy, S. J.; Huang, B. K.; Shevchenko, V. F.; Vann, R. G. L.

2016-02-01

Doppler backscattering (DBS) is already established as a powerful diagnostic; its extension to 2D enables imaging of turbulence characteristics from an extended region of the cut-off surface. The Synthetic Aperture Microwave Imaging (SAMI) diagnostic has conducted proof-of-principle 2D DBS experiments of MAST edge plasma. SAMI actively probes the plasma edge using a wide (±40° vertical and horizontal) and tuneable (10-34.5 GHz) beam. The Doppler backscattered signal is digitised in vector form using an array of eight Vivaldi PCB antennas. This allows the receiving array to be focused in any direction within the field of view simultaneously to an angular range of 6-24° FWHM at 10-34.5 GHz. This capability is unique to SAMI and is a novel way of conducting DBS experiments. In this paper the feasibility of conducting 2D DBS experiments is explored. Initial observations of phenomena previously measured by conventional DBS experiments are presented; such as momentum injection from neutral beams and an abrupt change in power and turbulence velocity coinciding with the onset of H-mode. In addition, being able to carry out 2D DBS imaging allows a measurement of magnetic pitch angle to be made; preliminary results are presented. Capabilities gained through steering a beam using a phased array and the limitations of this technique are discussed.

Explosive Chromospheric Evaporation Driven by Nonthermal Electrons around One Footpoint of a Solar Flare Loop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, D.; Ning, Z. J.; Huang, Y.

We explore the temporal relationship between microwave/hard X-ray (HXR) emission and Doppler velocity during the impulsive phase of a solar flare on 2014 October 27 (SOL2014-10-27) that displays a pulse on the light curves in the microwave (34 GHz) and HXR (25–50 keV) bands before the flare maximum. Imaging observation shows that this pulse mainly comes from one footpoint of a solar flare loop. The slit of the Interface Region Imaging Spectrograph ( IRIS ) stays at this footpoint during this solar flare. The Doppler velocities of Fe xxi 1354.09 Å and Si iv 1402.77 Å are extracted from themore » Gaussian fitting method. We find that the hot line of Fe xxi 1354.09 Å (log T ∼ 7.05) in the corona exhibits blueshift, while the cool line of Si iv 1402.77 Å (log T ∼ 4.8) in the transition region exhibits redshift, indicating explosive chromospheric evaporation. Evaporative upflows along the flare loop are also observed in the AIA 131 Å image. To our knowledge, this is the first report of chromospheric evaporation evidence from both spectral and imaging observations in the same flare. Both microwave and HXR pulses are well correlated with the Doppler velocities, suggesting that the chromospheric evaporation is driven by nonthermal electrons around this footpoint of a solar flare loop.« less

111-Indium platelet imaging, Doppler spectral analysis and angiography compared in patients with transient cerebral ischaemia.

PubMed

Goldman, M; Leung, J O; Aukland, A; Hawker, R J; Drolc, Z; McCollum, C N

1983-01-01

We have evaluated carotid gamma imaging using 111Indium-labelled platelets in the diagnosis of carotid artery disease and measured the accumulation of labelled platelets on endarterectomy specimens. Autologous 111In labelled platelets were injected in 25 patients with TIA. Gamma images were then taken daily and independently interpreted by two observers. Carotid endarterectomy was performed in 11 patients allowing measurement of the radioactivity on the operative specimen. These results were compared to the findings on angiography and Doppler spectral analysis. All endarterectomy specimens accumulated platelets with the most active equivalent to platelets from 1.8 ml blood. Atheromatous ulcers were more active than stenoses with mean (+/- SEM) activities of 1.12 +/- 0.37 and 0.38 +/- 0.10 respectively. These radioactivity levels were at the threshold of gamma camera resolution in a theoretical model. Both observers agreed that 22 of the 50 carotid bifurcations showed platelet accumulation on gamma imaging. Of the 12 atheromatous ulcers demonstrated by angiography 11 were visualized, but only five of ten stenoses greater than 80% were detected. As Doppler identified all stenoses only one angiographically diseased carotid was not detected by combining ultrasound with platelet scanning. Atherosclerotic arteries accumulate 111In platelets and the more thrombogenic ulcerated plaques are identified more frequently than stenoses. Long-term follow-up is required to establish the clinical relevance of platelet deposition.

Laser Doppler Velocimetry Workshop

NASA Technical Reports Server (NTRS)

Owen, R. B.

1979-01-01

The potential of laser Doppler velocimetry as a technique for use in mapping flows in the several fluid systems under development for doing research on low-gravity processes, is investigated. Laser Doppler velocimetry techniques, equipment, and applications are summarized.

Evaluation of transcatheter arterial embolization therapy on hepatocellular carcinomas using contrast-enhanced harmonic power Doppler sonography: comparison with CT, power Doppler sonography, and dynamic MRI.

PubMed

Shima, Toshihide; Mizuno, Masayuki; Otsuji, Hideaki; Mizuno, Chiemi; Obata, Hirozumi; Park, Hyohun; Nakajo, Shinobu; Okanoue, Takeshi

2005-09-01

The aim of this study was to assess and compare the sensitivity of power Doppler sonography, contrast-enhanced sonography, plain computed tomography (CT), and dynamic magnetic resonance imaging (MRI) for detecting hepatocellular carcinoma (HCC) nodules incompletely treated with transcatheter arterial embolization (TAE). A total of 63 unresectable HCC nodules were examined in this study. The HCCs were treated with TAE. All patients underwent plain CT, power Doppler sonography, contrast-enhanced harmonic power Doppler sonography, and dynamic MRI 1 week after TAE. The sensitivity of each modality to incompletely treated HCC nodules was compared. Detection of the residual viable HCC on angiography or tumor biopsy was regarded as the gold standard for the diagnosis of incomplete treatment. Twenty-four nodules (38%) were diagnosed as incompletely treated. The sensitivities of plain CT, power Doppler sonography, contrast-enhanced harmonic power Doppler sonography, and dynamic MRI to these incompletely treated nodules were 42% (10/24), 46% (11/24), 88% (21/24), and 79% (19/24), respectively. Eighty percent (19 nodules) of the 24 incompletely treated nodules were located within a depth of less than 8 cm. The sensitivities of plain CT, power Doppler sonography, contrast-enhanced harmonic power Doppler sonography, and dynamic MRI to these superficial incompletely treated nodules were 37% (7/19), 53% (10/19), 100% (19/19), and 74% (14/19), respectively. In contrast, the sensitivities of each modality to deeply located nodules were 60% (3/5), 20% (1/5), 40% (2/5), and 100% (5/5), respectively. Plain CT and power Doppler sonography had a low sensitivity to HCC nodules incompletely treated with TAE. Except for those that were deeply located, contrast-enhanced harmonic sonography showed the highest sensitivity in detecting incompletely treated HCC nodules.

Spectroscopic Doppler analysis for visible-light optical coherence tomography

NASA Astrophysics Data System (ADS)

Shu, Xiao; Liu, Wenzhong; Duan, Lian; Zhang, Hao F.

2017-12-01

Retinal oxygen metabolic rate can be effectively measured by visible-light optical coherence tomography (vis-OCT), which simultaneously quantifies oxygen saturation and blood flow rate in retinal vessels through spectroscopic analysis and Doppler measurement, respectively. Doppler OCT relates phase variation between sequential A-lines to the axial flow velocity of the scattering medium. The detectable phase shift is between -π and π due to its periodicity, which limits the maximum measurable unambiguous velocity without phase unwrapping. Using shorter wavelengths, vis-OCT is more vulnerable to phase ambiguity since flow induced phase variation is linearly related to the center wavenumber of the probing light. We eliminated the need for phase unwrapping using spectroscopic Doppler analysis. We split the whole vis-OCT spectrum into a series of narrow subbands and reconstructed vis-OCT images to extract corresponding Doppler phase shifts in all the subbands. Then, we quantified flow velocity by analyzing subband-dependent phase shift using linear regression. In the phantom experiment, we showed that spectroscopic Doppler analysis extended the measurable absolute phase shift range without conducting phase unwrapping. We also tested this method to quantify retinal blood flow in rodents in vivo.

Prostate: techniques, results, and potential applications of color Doppler US scanning.

PubMed

Rifkin, M D; Sudakoff, G S; Alexander, A A

1993-02-01

Color Doppler ultrasound (US) scanning and conventional endorectal gray-scale US of the prostate were performed in 619 patients. Pathologic correlation was available in all cases after US-guided transrectal biopsy. There were 132 cancers in 121 men, 13 foci of atypia in 10 men, 33 foci of inflammation in 31 men, and 469 benign lesions in 457 men. Two hundred seventy patients with abnormal areas of flow identified at color Doppler scanning also underwent spectral waveform analysis of the area of potential concern. No statistical difference in the mean resistive indexes was identified in any patient (P = .25; Scheffe F test, analysis of variance). All malignant lesions had abnormalities demonstrated at gray-scale US and/or focal or diffuse abnormal flow demonstrated at color Doppler scanning. Of the 132 cancers, 123 (93%) had corresponding gray-scale abnormalities and 114 (86%) demonstrated abnormal flow at color Doppler imaging. Nine of the 132 cancers (7%) had no obviously identifiable abnormality at gray-scale scanning but had distinctly abnormal flow at color Doppler scanning. Abnormal findings at color scanning without abnormal findings at gray-scale scanning occurred in eight of the 33 cases of inflammatory foci (24%) and in 24 of the 469 (5%) benign lesions.

Assessing the potential for measuring Europa's tidal Love number h2 using radar sounder and topographic imager data

NASA Astrophysics Data System (ADS)

Steinbrügge, G.; Schroeder, D. M.; Haynes, M. S.; Hussmann, H.; Grima, C.; Blankenship, D. D.

2018-01-01

The tidal Love number h2 is a key geophysical measurement for the characterization of Europa's interior, especially of its outer ice shell if a subsurface ocean is present. We performed numerical simulations to assess the potential for estimating h2 using altimetric measurements with a combination of radar sounding and stereo imaging data. The measurement principle exploits both delay and Doppler information in the radar surface return in combination with topography from a digital terrain model (DTM). The resulting radar range measurements at cross-over locations can be used in combination with radio science Doppler data for an improved trajectory solution and for estimating the h2 Love number. Our simulation results suggest that the absolute accuracy of h2 from the joint analysis of REASON (Radar for Europa Assessment and Sounding: Ocean to Near-surface) surface return and EIS (Europa Imaging System) DTM data will be in the range of 0.04-0.17 assuming full radio link coverage. The error is controlled by the SNR budget and DTM quality, both dependent on the surface properties of Europa. We estimate that this would unambiguously confirm (or reject) the global ocean hypothesis and, in combination with a nominal radio-science based measurement of the tidal Love number k2, constrain the thickness of Europa's outer ice shell to up to ±15 km.

Doppler-guided retrograde catheterization system

NASA Astrophysics Data System (ADS)

Frazin, Leon J.; Vonesh, Michael J.; Chandran, Krishnan B.; Khasho, Fouad; Lanza, George M.; Talano, James V.; McPherson, David D.

1991-05-01

The purpose of this study was to investigate a Doppler guided catheterization system as an adjunctive or alternative methodology to overcome the disadvantages of left heart catheterization and angiography. These disadvantages include the biological effects of radiation and the toxic and volume effects of iodine contrast. Doppler retrograde guidance uses a 20 MHz circular pulsed Doppler crystal incorporated into the tip of a triple lumen multipurpose catheter and is advanced retrogradely using the directional flow information provided by the Doppler waveform. The velocity detection limits are either 1 m/second or 4 m/second depending upon the instrumentation. In a physiologic flow model of the human aortic arch, multiple data points revealed a positive wave form when flow was traveling toward the catheter tip indicating proper alignment for retrograde advancement. There was a negative wave form when flow was traveling away from the catheter tip if the catheter was in a branch or bent upon itself indicating improper catheter tip position for retrograde advancement. In a series of six dogs, the catheter was able to be accurately advanced from the femoral artery to the left ventricular chamber under Doppler signal guidance without the use of x-ray. The potential applications of a Doppler guided retrograde catheterization system include decreasing time requirements and allowing safer catheter guidance in patients with atherosclerotic vascular disease and suspected aortic dissection. The Doppler system may allow left ventricular pressure monitoring in the intensive care unit without the need for x-ray and it may allow left sided contrast echocardiography. With pulse velocity detection limits of 4 m/second, this system may allow catheter direction and passage into the aortic root and left ventricle in patients with aortic stenosis. A modification of the Doppler catheter may include transponder technology which would allow precise catheter tip localization once the catheter tip is placed in the aortic root. Such technology may conceivably assist in allowing selective coronary catheterization. These studies have demonstrated that Doppler guided retrograde catheterization provides an accurate method to catheterization the aortic root and left ventricular chamber without x-ray. In humans, it may prove useful in a variety of settings including the development of invasive ultrasonic diagnostic and therapeutic technology.

Solar Dynamics Observatory Lessons Learned

NASA Technical Reports Server (NTRS)

Rivera, Rachel; Uhl, Andrew; Secunda, Mark

2010-01-01

Mission is to study how solar activity is created and how space weather results from that activity. Atmospheric Imaging Assembly (AIA): High Resolution Images of 10 wavelengths every 10 seconds. Extreme Ultraviolet Variability Experiment (EVE): Measure Sun's brightness in EUV. Helioseismic and Magnetic Imager (HMI): Measures Doppler shift to study waves of the Sun. Launched February 11, 2010.

Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging

PubMed Central

Greco, A.; Mancini, M.; Gargiulo, S.; Gramanzini, M.; Claudio, P. P.; Brunetti, A.; Salvatore, M.

2012-01-01

Ultrasound biomicroscopy (UBM) is a noninvasive multimodality technique that allows high-resolution imaging in mice. It is affordable, widely available, and portable. When it is coupled to Doppler ultrasound with color and power Doppler, it can be used to quantify blood flow and to image microcirculation as well as the response of tumor blood supply to cancer therapy. Target contrast ultrasound combines ultrasound with novel molecular targeted contrast agent to assess biological processes at molecular level. UBM is useful to investigate the growth and differentiation of tumors as well as to detect early molecular expression of cancer-related biomarkers in vivo and to monitor the effects of cancer therapies. It can be also used to visualize the embryological development of mice in uterus or to examine their cardiovascular development. The availability of real-time imaging of mice anatomy allows performing aspiration procedures under ultrasound guidance as well as the microinjection of cells, viruses, or other agents into precise locations. This paper will describe some basic principles of high-resolution imaging equipment, and the most important applications in molecular and preclinical imaging in small animal research. PMID:22163379

Musculoskeletal ultrasound and other imaging modalities in rheumatoid arthritis.

PubMed

Ohrndorf, Sarah; Werner, Stephanie G; Finzel, Stephanie; Backhaus, Marina

2013-05-01

This review refers to the use of musculoskeletal ultrasound in patients with rheumatoid arthritis (RA) both in clinical practice and research. Furthermore, other novel sensitive imaging modalities (high resolution peripheral quantitative computed tomography and fluorescence optical imaging) are introduced in this article. Recently published ultrasound studies presented power Doppler activity by ultrasound highly predictive for later radiographic erosions in patients with RA. Another study presented synovitis detected by ultrasound being predictive of subsequent structural radiographic destruction irrespective of the ultrasound modality (grayscale ultrasound/power Doppler ultrasound). Further studies are currently under way which prove ultrasound findings as imaging biomarkers in the destructive process of RA. Other introduced novel imaging modalities are in the validation process to prove their impact and significance in inflammatory joint diseases. The introduced imaging modalities show different sensitivities and specificities as well as strength and weakness belonging to the assessment of inflammation, differentiation of the involved structures and radiological progression. The review tries to give an answer regarding how to best integrate them into daily clinical practice with the aim to improve the diagnostic algorithms, the daily patient care and, furthermore, the disease's outcome.

Quantification of instantaneous flow rate and dynamically changing effective orifice area using a geometry independent three-dimensional digital color Doppler method: An in vitro study mimicking mitral regurgitation.

PubMed

Li, Xiaokui; Wanitkun, Suthep; Li, Xiang-Ning; Hashimoto, Ikuo; Mori, Yoshiki; Rusk, Rosemary A; Hicks, Shannon E; Sahn, David J

2002-10-01

Our study was intended to test the accuracy of a 3-dimensional (3D) digital color Doppler flow convergence (FC) method for assessing the effective orifice area (EOA) in a new dynamic orifice model mimicking a variety of mitral regurgitation. FC surface area methods for detecting EOA have been reported to be useful for quantifying the severity of valvular regurgitation. With our new 3D digital direct FC method, all raw velocity data are available and variable Nyquist limits can be selected for computation of direct FC surface area for computing instantaneous flow rate and temporal change of EOA. A 7.0-MHz multiplane transesophageal probe from an ultrasound system (ATL HDI 5000) was linked and controlled by a computer workstation to provide 3D images. Three differently shaped latex orifices (zigzag, arc, and straight slit, each with cutting-edge length of 1 cm) were used to mimic the dynamic orifice of mitral regurgitation. 3D FC surface computation was performed on parallel slices through the 3D data set at aliasing velocities (14-48 cm/s) selected to maximize the regularity and minimize lateral dropout of the visualized 3D FC at 5 points per cardiac cycle. Using continuous wave velocity for each, 3D-calculated EOA was compared with EOA determined by using continuous wave Doppler and the flow rate from a reference ultrasonic flow meter. Simultaneous digital video images were also recorded to define the actual orifice size for 9 stroke volumes (15-55 mL/beat with maximum flow rates 45-182 mL/s). Over the 9 pulsatile flow states and 3 orifices, 3D FC EOAs (0.05-0.63 cm(2)) from different phases of the cardiac cycle in each pump setting correlated well with reference EOA (r = 0.89-0.92, SEE = 0.027-0.055cm(2)) and they also correlated well with digital video images of the actual orifice peak (r = 0.97-0.98, SEE = 0.016-0.019 cm(2)), although they were consistently smaller, as expected by the contraction coefficient. The digital 3D FC method can accurately predict flow rate, and, thus, EOA (in conjunction with continuous wave Doppler), because it allows direct FC surface measurement despite temporal variability of FC shape.

Coherent Doppler lidar for automated space vehicle rendezvous, stationkeeping and capture

NASA Technical Reports Server (NTRS)

Bilbro, James A.

1991-01-01

The inherent spatial resolution of laser radar makes ladar or lidar an attractive candidate for Automated Rendezvous and Capture application. Previous applications were based on incoherent lidar techniques, requiring retro-reflectors on the target vehicle. Technology improvements (reduced size, no cryogenic cooling requirement) have greatly enhanced the construction of coherent lidar systems. Coherent lidar permits the acquisition of non-cooperative targets at ranges that are limited by the detection capability rather than by the signal-to-noise ratio (SNR) requirements. The sensor can provide translational state information (range, velocity, and angle) by direct measurement and, when used with any array detector, also can provide attitude information by Doppler imaging techniques. Identification of the target is accomplished by scanning with a high pulse repetition frequency (dependent on the SNR). The system performance is independent of range and should not be constrained by sun angle. An initial effort to characterize a multi-element detection system has resulted in a system that is expected to work to a minimum range of 1 meter. The system size, weight and power requirements are dependent on the operating range; 10 km range requires a diameter of 3 centimeters with overall size at 3 x 3 x 15 to 30 cm, while 100 km range requires a 30 cm diameter.

Classification of micro-Doppler signatures of human aquatic activity through simulation and measurement using transferred learning

NASA Astrophysics Data System (ADS)

Kim, Youngwook; Park, Jinhee; Moon, Taesup

2017-05-01

Remote detection of human aquatic activity can be applied not only to ocean surveillance but also to rescue operations. When a human is illuminated by electromagnetic waves, a Doppler signal is generated from his or her moving parts. Indeed, bodily movements are what make humans' micro-Doppler signatures unique, offering a chance to classify human motions. Certain studies have analyzed and attempted to recognize human aquatic activity, but the topic has yet to be extensively studied. In the present research, we simulate the micro-Doppler signatures of a swimming person in an attempt to investigate those signatures' characteristics. We model human arms as point scatterers while assuming a simple arm motion. By means of such a simulation, we can obtain spectrograms from a swimming person, then extend our measurement to multiple participants. Measurements are taken from five aquatic activities featuring five participants, comprising freestyle, backstroke, and breaststroke, pulling a boat, and rowing. As suggested by the simulation study, the spectrograms for the five activities show different micro-Doppler signatures; hence, we propose to classify them using a deep convolutional neural network (DCNN). In particular, we suggest the use of a transfer-learned DCNN, which is based on a DCNN pretrained by a large-scale RGB image dataset that is, ImageNet. The classification accuracy is calculated using fivefold cross-validation on our dataset. We find that a DCNN trained through transfer learning achieves the highest accuracy while also providing a significant performance boost over the conventional classification method.

Comparison of tissue Doppler echocardiography parameters in patients with end-stage renal disease and renal transplant recipients.

PubMed

Pirat, B; Bozbas, H; Demirtas, S; Simsek, V; Sayin, B; Colak, T; Sade, E; Ulucam, M; Muderrisoglu, H; Haberal, M

2008-01-01

Tissue Doppler echocardiography has been introduced as a useful tool to assess systolic myocardial function. In this study we sought to compare patients with end-stage renal disease (ESRD), with renal transplantations and control subjects with regard to tissue Doppler parameters. Thirty recipients with functional grafts of overall mean age 36 +/- 7 years included 24 men. An equal number of patients with ESRD of overall mean age 35 +/- 7 years included 20 men. A third cohort was comprised of 20 age- and gender matched control subjects. Tissue Doppler imaging from the septal and lateral mitral annulus of the left ventricle and free wall of the right ventricle was performed from a 4-chamber view. Mean systolic and diastolic blood pressures were similar among the groups during imaging. Peak systolic velocity (S wave) at the septal annulus was similar in control subjects and recipients. S waves were significantly lower among ESRD patients compared with recipients (10.3 +/- 2.1 vs 12.0 +/- 2.5 cm/s, P = .04, respectively). Isovolumic contraction velocity of the septum and the right ventricular wall were significantly lower in ESRD patients than recipients or controls: 10.2 +/- 2.6 vs 12.5 +/- 2.8 vs 11.4 +/- 1.8 cm/s for septal wall (P = .008) and 13.9 +/- 3.6 vs 17.9 +/- 5.1 vs 16.8 +/- 5.8, for right ventricle (P = .01). Systolic indices of tissue Doppler echocardiography in recipients demonstrated similar values as control subjects and increased values compared with ESRD patients. These results suggested improvement in systolic myocardial function following renal transplantation.

Distinguishing Buried Objects in Extremely Shallow Underground by Frequency Response Using Scanning Laser Doppler Vibrometer

NASA Astrophysics Data System (ADS)

Abe, Touma; Sugimoto, Tsuneyoshi

2010-07-01

A sound wave vibration using a scanning laser Doppler vibrometer are used as a method of exploring and imaging an extremely shallow underground. Flat speakers are used as a vibration source. We propose a method of distinguishing a buried object using a response range of a frequencies corresponding to a vibration velocities. Buried objects (plastic containers, a hollow steel can, an unglazed pot, and a stone) are distinguished using a response range of frequencies. Standardization and brightness imaging are used as methods of discrimination. As a result, it was found that the buried objects show different response ranges of frequencies. From the experimental results, we confirmed the effectiveness of our proposed method.

SHEAR WAVE DISPERSION MEASURES LIVER STEATOSIS

PubMed Central

Barry, Christopher T.; Mills, Bradley; Hah, Zaegyoo; Mooney, Robert A.; Ryan, Charlotte K.; Rubens, Deborah J.; Parker, Kevin J.

2012-01-01

Crawling waves, which are interfering shear wave patterns, can be generated in liver tissue over a range of frequencies. Some important biomechanical properties of the liver can be determined by imaging the crawling waves using Doppler techniques and analyzing the patterns. We report that the dispersion of shear wave velocity and attenuation, that is, the frequency dependence of these parameters, are strongly correlated with the degree of steatosis in a mouse liver model, ex vivo. The results demonstrate the possibility of assessing liver steatosis using noninvasive imaging methods that are compatible with color Doppler scanners and, furthermore, suggest that liver steatosis can be separated from fibrosis by assessing the dispersion or frequency dependence of shear wave propagations. PMID:22178165

Tissue Doppler and strain imaging: anything left in the echo-lab?

PubMed Central

Citro, Rodolfo; Bossone, Eduardo; Kuersten, Bettina; Gregorio, Giovanni; Salustri, Alessandro

2008-01-01

Medline research indicates that an increasing number of manuscripts have been published in the last decade claiming, the feasibility and the potential clinical role of tissue Doppler and strain/strain rate imaging. However, despite this amount of scientific evidence, these technologies are still confined to dedicated, high-tech, research-oriented echocardiography laboratories. In this review we have critically evaluated these techniques, analysing their physical principles, the technical problems related to their current clinical application, and the future perspectives. Finally, this review explores the reasons why these technologies are still defined "new technologies" and the impact of their implementation on the current clinical activity of an echocardiography laboratory. PMID:18973677

IIP Update: A Packaged Coherent Doppler Wind Lidar Transceiver. Doppler Aerosol WiNd Lidar (DAWN)

NASA Technical Reports Server (NTRS)

Kavaya, Michael J.; Koch, Grady J.; Yu, Jirong; Trieu, Bo C.; Amzajerdian, Farzin; Singh, Upendra N.; Petros, Mulugeta

2006-01-01

The state-of-the-art 2-micron coherent Doppler wind lidar breadboard at NASA/LaRC will be engineered and compactly packaged consistent with future aircraft flights. The packaged transceiver will be integrated into a coherent Doppler wind lidar system test bed at LaRC. Atmospheric wind measurements will be made to validate the packaged technology. This will greatly advance the coherent part of the hybrid Doppler wind lidar solution to the need for global tropospheric wind measurements.

Doppler-shift compensation in the Taiwanese leaf-nosed bat (Hipposideros terasensis) recorded with a telemetry microphone system during flight

NASA Astrophysics Data System (ADS)

Hiryu, Shizuko; Katsura, Koji; Lin, Liang-Kong; Riquimaroux, Hiroshi; Watanabe, Yoshiaki

2005-12-01

Biosonar behavior was examined in Taiwanese leaf-nosed bats (Hipposideros terasensis; CF-FM bats) during flight. Echolocation sounds were recorded using a telemetry microphone mounted on the bat's head. Flight speed and three-dimensional trajectory of the bat were reconstructed from images taken with a dual high-speed video camera system. Bats were observed to change the intensity and emission rate of pulses depending on the distance from the landing site. Frequencies of the dominant second harmonic constant frequency component (CF2) of calls estimated from the bats' flight speed agreed strongly with observed values. Taiwanese leaf-nosed bats changed CF2 frequencies depending on flight speed, which caused the CF2 frequencies of the Doppler-shifted echoes to remain constant. Pulse frequencies were also estimated using echoes returning directly ahead of the bat and from its sides for two different flight conditions: landing and U-turn. Bats in flight may periodically alter their attended angles from the front to the side when emitting echolocation pulses.

Doppler centroid estimation ambiguity for synthetic aperture radars

NASA Technical Reports Server (NTRS)

Chang, C. Y.; Curlander, J. C.

1989-01-01

A technique for estimation of the Doppler centroid of an SAR in the presence of large uncertainty in antenna boresight pointing is described. Also investigated is the image degradation resulting from data processing that uses an ambiguous centroid. Two approaches for resolving ambiguities in Doppler centroid estimation (DCE) are presented: the range cross-correlation technique and the multiple-PRF (pulse repetition frequency) technique. Because other design factors control the PRF selection for SAR, a generalized algorithm is derived for PRFs not containing a common divisor. An example using the SIR-C parameters illustrates that this algorithm is capable of resolving the C-band DCE ambiguities for antenna pointing uncertainties of about 2-3 deg.

Corrected tetralogy of Fallot: comparison of tissue doppler imaging and velocity-encoded MR for assessment of performance and temporal activation of right ventricle.

PubMed

van der Hulst, Annelies E; Roest, Arno A W; Delgado, Victoria; Kroft, Lucia J M; Holman, Eduard R; Blom, Nico A; Bax, Jeroen J; de Roos, Albert; Westenberg, Jos J M

2011-07-01

To compare velocity-encoded (VE) magnetic resonance (MR) imaging with tissue Doppler imaging to assess right ventricular (RV) peak systolic velocities and timing of velocities in patients with corrected tetralogy of Fallot and healthy subjects. Local institutional review board approval was obtained; patients or their parents gave informed consent. Thirty-three patients (20 male, 13 female; median age, 12 years; interquartile range [IQR], 11-15 years; age range, 8-18 years) and 19 control subjects (12 male, seven female; median age, 14 years; IQR, 12-16 years; age range, 8-18 years) underwent VE MR imaging and tissue Doppler imaging. Peak systolic velocity and time to peak systolic velocity (percentage of cardiac cycle) were assessed at the RV free wall (RVFW) and RV outflow tract (RVOT). Data were analyzed by using linear regression, paired and unpaired tests, and Bland-Altman plots. Good correlation and agreement between the two techniques were observed. For peak systolic velocity at RVFW, r = 0.95 (mean difference, -0.4 cm/sec, P < .01), and at RVOT, r = 0.95 (mean difference, -0.4 cm/sec, P = .02). For timing at RVFW, r = 0.94 (mean difference, -0.2%, P = .44), and at RVOT, r = 0.89 (mean difference, -0.5%, P = .01). Peak systolic velocity was reduced in patients with corrected tetralogy of Fallot (at RVFW, median was 8.2 cm/sec [IQR, 6.4-9.7 cm/sec] vs 12.4 cm/sec [IQR, 10.8-13.8 cm/sec], P < .01; at RVOT, 4.7 cm/sec [IQR, 4.1-7.2 cm/sec] vs 10.2 cm/sec [IQR, 8.7-11.2 cm/sec], P < .01). The time delay between RVFW and RVOT was observed, which was significantly shorter in patients with corrected tetralogy of Fallot (median, 5.9% [IQR, 4.9%-7.4%] vs 8.4% [IQR, 6.6%-12.4%], P < .01). VE MR imaging and tissue Doppler imaging enable assessment of RV systolic performance and timing of velocities at the RVFW and RVOT in patients with corrected tetralogy of Fallot. Both techniques can be used interchangeably to clinically assess velocities and timing of velocities of the RV.

Remote Sensing Wind and Wind Shear System.

DTIC Science & Technology

Contents: Remote sensing of wind shear and the theory and development of acoustic doppler; Wind studies; A comparison of methods for the remote detection of winds in the airport environment; Acoustic doppler system development; System calibration; Airport operational tests.

Application of the Doppler lidar system to agricultural burning and air-sea interactions

NASA Technical Reports Server (NTRS)

Fitzjarrald, D.

1980-01-01

The Doppler lidar system is potentially a very powerful measurement system. Three areas concerning the system are discussed: (1) error analysis of the system to verify the results; (2) application of the system to agricultural burning in California central valley; and (3) oceanographic possibilities of the system.

Quantitative characterization of color Doppler images: reproducibility, accuracy, and limitations.

PubMed

Delorme, S; Weisser, G; Zuna, I; Fein, M; Lorenz, A; van Kaick, G

1995-01-01

A computer-based quantitative analysis for color Doppler images of complex vascular formations is presented. The red-green-blue-signal from an Acuson XP10 is frame-grabbed and digitized. By matching each image pixel with the color bar, color pixels are identified and assigned to the corresponding flow velocity (color value). Data analysis consists of delineation of a region of interest and calculation of the relative number of color pixels in this region (color pixel density) as well as the mean color value. The mean color value was compared to flow velocities in a flow phantom. The thyroid and carotid artery in a volunteer were repeatedly examined by a single examiner to assess intra-observer variability. The thyroids in five healthy controls were examined by three experienced physicians to assess the extent of inter-observer variability and observer bias. The correlation between the mean color value and flow velocity ranged from 0.94 to 0.96 for a range of velocities determined by pulse repetition frequency. The average deviation of the mean color value from the flow velocity was 22% to 41%, depending on the selected pulse repetition frequency (range of deviations, -46% to +66%). Flow velocity was underestimated with inadequately low pulse repetition frequency, or inadequately high reject threshold. An overestimation occurred with inadequately high pulse repetition frequency. The highest intra-observer variability was 22% (relative standard deviation) for the color pixel density, and 9.1% for the mean color value. The inter-observer variation was approximately 30% for the color pixel density, and 20% for the mean color value. In conclusion, computer assisted image analysis permits an objective description of color Doppler images. However, the user must be aware that image acquisition under in vivo conditions as well as physical and instrumental factors may considerably influence the results.

Transcranial functional ultrasound imaging of the brain using microbubble-enhanced ultrasensitive Doppler

PubMed Central

Errico, Claudia; Osmanski, Bruno-Félix; Pezet, Sophie; Couture, Olivier; Lenkei, Zsolt; Tanter, Mickael

2016-01-01

Functional ultrasound (fUS) is a novel neuroimaging technique, based on high-sensitivity ultrafast Doppler imaging of cerebral blood volume, capable of measuring brain activation and connectivity in rodents with high spatiotemporal resolution (100 μm, 1 ms). However, the skull attenuates acoustic waves, so fUS in rats currently requires craniotomy or a thinned-skull window. Here we propose a non-invasive approach by enhancing the fUS signal with a contrast agent, inert gas microbubbles. Plane-wave illumination of the brain at high frame rate (500 Hz compounded sequence with three tilted plane waves, PRF = 1500Hz with a 128 element 15 MHz linear transducer), yields highly-resolved neurovascular maps. We compared fUS imaging performance through the intact skull bone (transcranial fUS) versus a thinned-skull window in the same animal. First, we show that the vascular network of the adult rat brain can be imaged transcranially only after a bolus intravenous injection of microbubbles, which leads to a 9 dB gain in the contrast-to-tissue ratio. Next, we demonstrate that functional increase in the blood volume of the primary sensory cortex after targeted electrical-evoked stimulations of the sciatic nerve is observable transcranially in presence of contrast agents, with high reproducibility (Pearson's coefficient ρ = 0.7 ± 0.1, p = 0.85). Our work demonstrates that the combination of ultrafast Doppler imaging and injection of contrast agent allows non-invasive functional brain imaging through the intact skull bone in rats. These results should ease non-invasive longitudinal studies in rodents and open a promising perspective for the adoption of highly resolved fUS approaches for the adult human brain. PMID:26416649

[Validation of a new hand-carried ultrasound device equipped with directional color power Doppler and continuous wave Doppler].

PubMed

Kawai, Junichi; Tanabe, Kazuaki; Matsuzaki, Masashi; Yamaguchi, Kazuto; Yagi, Toshikazu; Fujii, Yoko; Konda, Toshiko; Ui, Kazuyo; Sumida, Toshiaki; Okada, Midori; Tani, Tomoko; Morioka, Shigefumi

2003-10-01

This study evaluated the accuracy of the directional color power Doppler (DCPD) and continuous wave Doppler (CWD) methods incorporated in the new hand-carried SonoSite 180PLUS ultrasound device. The hand-held ultrasound system with 2.5 MHz transducer and SONOS 5500 was used as a standard ultrasound system with a 2 to 4 MHz wideband transducer. The experimental study used a Doppler wire phantom to evaluate the influence of target wire speed and angle of transducer on DCPD imaging. The clinical study included 48 consecutive patients. DCPD assessment of valvular regurgitation measured the distances of DCPD signals of mitral, aortic and tricuspid valve regurgitation using the apical four-chamber view for comparison with standard echocardiography. CWD assessment measured the peak velocities of the aortic flow and tricuspid valve regurgitant flow for comparison with standard echocardiography. In the experimental study, DCPD signals were not influenced by target wire speed changes and transducer incident angles. In the clinical study, agreements for mitral, aortic and tricuspid regurgitation between the two methods were 89.6%, 81.8% and 78.7%, respectively. The distances of DCPD valve regurgitant signals by the hand-carried ultrasound device showed good correlation (mitral regurgitation: y = 0.84x + 0.55; r = 0.93, aortic regurgitation: y = 0.95x + 0.27; r = 0.94, tricuspid regurgitation: y = 0.86x + 0.61; r = 0.90) with those by standard echocardiography. Evaluation of CWD velocity measurements showed good agreement for the lower flow velocities (< 2.0 m/sec). However, underestimation occurred for the high flow velocities (> 2.0 m/sec) compared with those by standard echocardiography (aortic flow: y = 0.80x + 0.11; r = 0.95, tricuspid regurgitation: y = 1.00x - 0.23; r = 0.90). The new hand-carried ultrasound device (SonoSite 180PLUS equipped with DCPD and CWD) is clinically useful for evaluating valvular regurgitations and flow velocities. Further studies are needed to determine the mechanism of the underestimation of high flow velocities by CWD.

Angiosonography in suspicious breast lesions with non-diagnostic FNAC: comparison with power Doppler US.

PubMed

Caumo, F; Carbognin, G; Casarin, A; Pinali, L; Vasori, S; D'Onofrio, M; Pozzi Mucelli, R

2006-02-01

The purpose of this study was to evaluate the accuracy of angiosonography in comparison with colour Doppler ultrasound (US) in the discrimination of suspicious breast lesions with nondiagnostic fine-needle aspiration cytology (FNAC). Pre-operative Power Doppler US and angiosonography were prospectively performed in 20 suspicious breast lesions with non-diagnostic FNAC. A second-generation US contrast agent was utilised with a high-frequency transducer and a contrast-specific algorithm (low acoustic pressure CnTI). The enhancement characteristics of all lesions were analysed using qualitative and quantitative parameters obtained from time-intensity curves with the different imaging modalities. The final diagnosis was confirmed at pathology in all cases. Microvessel density (MVD) was assessed in the surgical specimen using CD34. The correct assessment of biological behaviour was achieved in all cases by angiosonography (sensitivity of 100%; specificity of 91%) and colour Doppler US (45% sensitivity; 78% specificity). MVD correlated with the biological behaviour. Angiosonography is more accurate than colour Doppler US in the correct assessment of biological behaviour of suspicious breast lesions.

Real-time three-dimensional color Doppler echocardiography for characterizing the spatial velocity distribution and quantifying the peak flow rate in the left ventricular outflow tract

NASA Technical Reports Server (NTRS)

Tsujino, H.; Jones, M.; Shiota, T.; Qin, J. X.; Greenberg, N. L.; Cardon, L. A.; Morehead, A. J.; Zetts, A. D.; Travaglini, A.; Bauer, F.;

Using Flow Characteristics in Three-Dimensional Power Doppler Ultrasound Imaging to Predict Complete Responses in Patients Undergoing Neoadjuvant Chemotherapy.

PubMed

Shia, Wei-Chung; Huang, Yu-Len; Wu, Hwa-Koon; Chen, Dar-Ren

2017-05-01

Strategies are needed for the identification of a poor response to treatment and determination of appropriate chemotherapy strategies for patients in the early stages of neoadjuvant chemotherapy for breast cancer. We hypothesize that power Doppler ultrasound imaging can provide useful information on predicting response to neoadjuvant chemotherapy. The solid directional flow of vessels in breast tumors was used as a marker of pathologic complete responses (pCR) in patients undergoing neoadjuvant chemotherapy. Thirty-one breast cancer patients who received neoadjuvant chemotherapy and had tumors of 2 to 5 cm were recruited. Three-dimensional power Doppler ultrasound with high-definition flow imaging technology was used to acquire the indices of tumor blood flow/volume, and the chemotherapy response prediction was established, followed by support vector machine classification. The accuracy of pCR prediction before the first chemotherapy treatment was 83.87% (area under the ROC curve [AUC] = 0.6957). After the second chemotherapy treatment, the accuracy of was 87.9% (AUC = 0.756). Trend analysis showed that good and poor responders exhibited different trends in vascular flow during chemotherapy. This preliminary study demonstrates the feasibility of using the vascular flow in breast tumors to predict chemotherapeutic efficacy. © 2017 by the American Institute of Ultrasound in Medicine.

Transesophageal Doppler measurement of renal arterial blood flow velocities and indices in children.

PubMed

Zabala, Luis; Ullah, Sana; Pierce, Carol D'Ann; Gautam, Nischal K; Schmitz, Michael L; Sachdeva, Ritu; Craychee, Judith A; Harrison, Dale; Killebrew, Pamela; Bornemeier, Renee A; Prodhan, Parthak

2012-06-01

Doppler-derived renal blood flow indices have been used to assess renal pathologies. However, transesophageal ultrasonography (TEE) has not been previously used to assess these renal variables in pediatric patients. In this study, we (a) assessed whether TEE allows adequate visualization of the renal parenchyma and renal artery, and (b) evaluated the concordance of TEE Doppler-derived renal blood flow measurements/indices compared with a standard transabdominal renal ultrasound (TAU) in children. This prospective cohort study enrolled 28 healthy children between the ages of 1 and 17 years without known renal dysfunction who were undergoing atrial septal defect device closure in the cardiac catheterization laboratory. TEE was used to obtain Doppler renal artery blood velocities (peak systolic velocity, end-diastolic velocity, mean diastolic velocity, resistive index, and pulsatility index), and these values were compared with measurements obtained by TAU. Concordance correlation coefficient (CCC) was used to determine clinically significant agreement between the 2 methods. The Bland-Altman plots were used to determine whether these 2 methods agree sufficiently to be used interchangeably. Statistical significance was accepted at P ≤ 0.05. Obtaining 2-dimensional images of kidney parenchyma and Doppler-derived measurements using TEE in children is feasible. There was statistically significant agreement between the 2 methods for all measurements. The CCC between the 2 imaging techniques was 0.91 for the pulsatility index and 0.66 for the resistive index. These coefficients were sensitive to outliers. When the highest and lowest data points were removed from the analysis, the CCC between the 2 imaging techniques was 0.62 for the pulsatility index and 0.50 for the resistive index. The 95% confidence interval (CI) for pulsatility index was 0.35 to 0.98 and for resistive index was 0.21 to 0.89. The Bland-Altman plots indicate good agreement between the 2 methods; for the pulsatility index, the limits of agreement were -0.80 to 0.53. The correlation of the size of the measurement and the mean difference in methods (-0.14; 95% CI = -0.28, 0.01) was not statistically significant (r = 0.31, P = 0.17). For the resistive index, the limits of agreement were -0.22 to 0.12. The correlation of the size of the measurement and the mean difference in methods (-0.05; 95% CI = -0.09, -0.01) was not statistically significant (r = 0.10, P = 0.65). This study confirms the feasibility of obtaining 2-dimensional images of kidney parenchyma and Doppler-derived measurements using TEE in children. Angle-independent TEE Doppler-derived indices show significant concordance with those derived by TAU. Further studies are required to assess whether this correlation holds true in the presence of renal pathology. This technique has the potential to help modulate intraoperative interventions based on their impact on renal variables and may prove helpful in the perioperative period for children at risk of acute kidney injury.

The role of modern diagnostic imaging in diagnosing and differentiating kidney diseases in children.

PubMed

Maliborski, Artur; Zegadło, Arkadiusz; Placzyńska, Małgorzata; Sopińska, Małgorzata; Lichosik, Marianna; Jobs, Katarzyna

2018-01-01

Urinary tract diseases are in the group of the most commonly diagnosed medical conditions in pediatric patients. Many diseases with different etiologies are accompanied by pain, fever, hematuria, or urinary tract dysfunction. Those most common ones in children are urinary tract infections and congenital malformation. They can also represent tumors or changes caused by systemic diseases. Clinical tests and even more often additional imaging studies are required to make a proper diagnosis of urinary tract diseases. Just a few decades ago urography, cystography or voiding cystourethrography were the main methods in diagnostic imaging of the urinary tract. Today's imaging methods supported by digital radiographic and fluoroscopy systems, high sensitivity detectors with quantum detection, advanced algorithms eliminating motion artifacts, modern medical imaging monitors with a resolution of three or even eight megapixels significantly differ from conventional radiographic methods. The methods that are currently usually performed are: computed tomography, magnetic resonance imaging, isotopic methods and ultrasonography using elastography and new solutions in Doppler imaging. Modern techniques are currently focused on reducing radiation exposure with better imaging capabilities. The development of these techniques became an essential diagnostic aid in nephrological and urological practice. The aim of this paper is to present the latest solutions that are currently used in the diagnostic imaging of urinary tract diseases.

Modeling the Performance of Direct-Detection Doppler Lidar Systems in Real Atmospheres

NASA Technical Reports Server (NTRS)

McGill, Matthew J.; Hart, William D.; McKay, Jack A.; Spinhirne, James D.

1999-01-01

Previous modeling of the performance of spaceborne direct-detection Doppler lidar systems has assumed extremely idealized atmospheric models. Here we develop a technique for modeling the performance of these systems in a more realistic atmosphere, based on actual airborne lidar observations. The resulting atmospheric model contains cloud and aerosol variability that is absent in other simulations of spaceborne Doppler lidar instruments. To produce a realistic simulation of daytime performance, we include solar radiance values that are based on actual measurements and are allowed to vary as the viewing scene changes. Simulations are performed for two types of direct-detection Doppler lidar systems: the double-edge and the multi-channel techniques. Both systems were optimized to measure winds from Rayleigh backscatter at 355 nm. Simulations show that the measurement uncertainty during daytime is degraded by only about 10-20% compared to nighttime performance, provided a proper solar filter is included in the instrument design.

Modeling the performance of direct-detection Doppler lidar systems including cloud and solar background variability.

PubMed

McGill, M J; Hart, W D; McKay, J A; Spinhirne, J D

1999-10-20

Previous modeling of the performance of spaceborne direct-detection Doppler lidar systems assumed extremely idealized atmospheric models. Here we develop a technique for modeling the performance of these systems in a more realistic atmosphere, based on actual airborne lidar observations. The resulting atmospheric model contains cloud and aerosol variability that is absent in other simulations of spaceborne Doppler lidar instruments. To produce a realistic simulation of daytime performance, we include solar radiance values that are based on actual measurements and are allowed to vary as the viewing scene changes. Simulations are performed for two types of direct-detection Doppler lidar system: the double-edge and the multichannel techniques. Both systems were optimized to measure winds from Rayleigh backscatter at 355 nm. Simulations show that the measurement uncertainty during daytime is degraded by only approximately 10-20% compared with nighttime performance, provided that a proper solar filter is included in the instrument design.

Compact, High Energy 2-micron Coherent Doppler Wind Lidar Development for NASA's Future 3-D Winds Measurement from Space

NASA Technical Reports Server (NTRS)

Singh, Upendra N.; Koch, Grady; Yu, Jirong; Petros, Mulugeta; Beyon, Jeffrey; Kavaya, Michael J.; Trieu, Bo; Chen, Songsheng; Bai, Yingxin; Petzar, paul;

A Planar-Fluorescence Imaging Technique for Studying Droplet-Turbulence Interactions in Vaporizing Sprays

NASA Technical Reports Server (NTRS)

Santavicca, Dom A.; Coy, E.

1990-01-01

Droplet turbulence interactions directly affect the vaporization and dispersion of droplets in liquid sprays and therefore play a major role in fuel oxidizer mixing in liquid fueled combustion systems. Proper characterization of droplet turbulence interactions in vaporizing sprays require measurement of droplet size velocity and size temperature correlations. A planar, fluorescence imaging technique is described which is being developed for simultaneously measuring the size, velocity, and temperature of individual droplets in vaporizing sprays. Preliminary droplet size velocity correlation measurements made with this technique are presented. These measurements are also compared to and show very good agreement with measurements made in the same spray using a phase Doppler particle analyzer.

Relationship between loss of echogenicity and cavitation emissions from echogenic liposomes insonified by spectral Doppler ultrasound

NASA Astrophysics Data System (ADS)

Radhakrishnan, Kirthi

Cardiovascular disease is the leading cause of death and disability in the United States and worldwide. Echogenic liposomes (ELIP) are theragonistic ultrasound contrast agents (UCAs) being developed for the early detection and treatment of cardiovascular disease. Stability of the echogenicity of ELIP in physiologic conditions is crucial to their successful translation to clinical use. The stability of ELIP echogenicity was determined in vitro under physiologic conditions of total dissolved gas concentration, temperature, and hydrodynamic pressure in porcine plasma and whole blood. Ultrasound contrast agents (UCAs) have the potential to nucleate cavitation and promote both beneficial and deleterious bioeffects in vivo. Previous studies have elucidated the pressure amplitude threshold for rapid loss of echogenicity due to UCA fragmentation as a function of pulse duration and pulse repetition frequency (PRF). Previous studies have also demonstrated that UCA fragmentation was concomitant with inertial cavitation. The purpose of this study was to evaluate the relationship between stable and inertial cavitation thresholds and loss of echogenicity of ELIP as a function of pulse duration and pulse repetition frequency. Determining the relationship between cavitation thresholds and loss of echogenicity of ELIP would enable monitoring of cavitation based upon the on-screen echogenicity in clinical applications. ELIP were insonified by a clinical ultrasound scanner in duplex spectral Doppler mode at four pulse durations and four PRFs in a static fluid and in a flow system. Cavitation emissions from the UCAs insonified by Doppler pulses were recorded using a single-element passive cavitation detection (PCD) system and a passive cavitation imaging (PCI) system. Stable and inertial cavitation thresholds were ascertained. Loss of echogenicity from ELIP was assessed within regions of interest on B-mode images. Stable cavitation thresholds were found to be lower than inertial cavitation thresholds. Stable and inertial cavitation thresholds of ELIP were found to have a weak dependence on pulse duration. However, the stable cavitation threshold of ELIP had no dependence on PRF. The inertial cavitation threshold of ELIP had a weak dependence on PRF. Cavitation thresholds ascertained using a PCI agreed with the thresholds ascertained using a single-element PCD. The azimuthal beamwidth of the cavitation emissions detected by the PCI system agreed with the calibrated beamwidth of the insonation Doppler pressure exceeding the cavitation threshold. The power of cavitation emissions was an exponential function of the loss of echogenicity over the investigated range of acoustic pressures. ELIP lost more than 80% echogenicity before the onset of stable or inertial cavitation. Once this level of echogenicity loss occurred, both stable and inertial cavitation emissions were detected in the physiologic flow phantom. These results indicate that 80% loss of echogenicity may be used as a qualitative metric to gauge the onset of stable and inertial cavitation from ELIP.

The use of breast ultrasound color Doppler vascular pattern morphology improves diagnostic sensitivity with minimal change in specificity.

PubMed

Svensson, W E; Pandian, A J; Hashimoto, H

2010-10-01

The aim of this study was to evaluate the use of vascular morphology, around and within the B-mode region of abnormality, for improving the diagnostic accuracy of two of the most common solid breast pathologies. The B-mode and Doppler images of 117 breast cancers and 366 fibroadenomas and lesions with a fibroadenoma-like appearance were reviewed retrospectively and the morphology of the vascular pattern was evaluated. The ratio of external to internal color Doppler, the external vascular pattern and the connecting vessels to internal vessels were assessed and differentiated into benign and malignant vascular patterns. These patterns were correlated with the histological diagnosis. Vascularity was demonstrated in 95 % of cancers and in 46 % of benign lesions with a trend to increasing vascularity in cancers. This provided poor specificity for excluding cancer in fibroadenomas. Variations in vascular pattern were recorded. The observed benign vascular patterns were avascularity, vascularity in the periphery and peripheral marginal vessels connecting with internal vascularity. The observed malignant vascular patterns were radially aligned external vessels with internal vessels being more numerous than external vessels which connected to radial vessels. (Fisher exact test p < 0.0001). Analysis of the vascular morphology improved the sensitivity for identifying cancers from 97 % (B-mode) to 99 % (B-mode and color Doppler) with a minimal reduction in specificity (93.7 to 92.6 %) or accuracy (94.6 to 94.2 %). The presence of vascularity within a lesion, by itself, is no longer a good predictor of malignancy because of the increase in Doppler sensitivity associated with improvements in ultrasound technology. The color Doppler ultrasound vascular pattern morphology improves the accuracy and sensitivity of B-mode image diagnosis, breast cancers and fibroadenomas with a minimal loss of specificity. Any breast lesion with radial rather than marginal connecting vessels should be regarded with suspicion. © Georg Thieme Verlag KG Stuttgart · New York.

Spatiotemporal image correlation-derived volumetric Doppler impedance indices from spherical samples of the placenta: intraobserver reliability and correlation with conventional umbilical artery Doppler indices.

PubMed

Welsh, A W; Hou, M; Meriki, N; Martins, W P

2012-10-01

Volumetric impedance indices derived from spatiotemporal image correlation (STIC) power Doppler ultrasound (PDU) might overcome the influence of machine settings and attenuation. We examined the feasibility of obtaining these indices from spherical samples of anterior placentas in healthy pregnancies, and assessed intraobserver reliability and correlation with conventional umbilical artery (UA) impedance indices. Uncomplicated singleton pregnancies with anterior placenta were included in the study. A single observer evaluated UA pulsatility index (PI), resistance index (RI) and systolic/diastolic ratio (S/D) and acquired three STIC-PDU datasets from the placenta just above the placental cord insertion. Another observer analyzed the STIC-PDU datasets using Virtual Organ Computer-aided AnaLysis (VOCAL) spherical samples from every frame to determine the vascularization index (VI) and vascularization flow index (VFI); maximum, minimum and average values were used to determine the three volumetric impedance indices (vPI, vRI, vS/D). Intraobserver reliability was examined by intraclass correlation coefficients (ICC) and association between volumetric indices from placenta, and UA Doppler indices were assessed by Pearson's correlation coefficient. A total of 25 pregnant women were evaluated but five were excluded because of artifacts observed during analysis. The reliability of measurement of volumetric indices of both VI and VFI from three STIC-PDU datasets was similar, with all ICCs ≥ 0.78. Pearson's r values showed a weak and non-significant correlation between UA pulsed-wave Doppler indices and their respective volumetric indices from spherical samples of placenta (all r ≥ 0.23). VOCAL indices from specific phases of the cardiac cycle showed good repeatability (ICC ≥ 0.92). Volumetric impedance indices determined from spherical samples of placenta are sufficiently reliable but do not correlate with UA Doppler indices in healthy pregnancies. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.

Power Doppler Ultrasonography and Shear Wave Elastography as Complementary Imaging Methods for Suspected Local Breast Cancer Recurrence.

PubMed

Jales, Rodrigo Menezes; Dória, Maira Teixeira; Serra, Kátia Piton; Miranda, Mila Meneguelli; Menossi, Carlos Alberto; Schumacher, Klaus; Sarian, Luis Otávio

2018-06-01

To prospectively investigate the diagnostic accuracy and clinical consequences of power Doppler morphologic criteria and shear wave elastography (SWE) as complementary imaging methods for evaluation of suspected local breast cancer recurrence in the ipsilateral breast or chest wall. Thirty-two breast masses with a suspicion of local breast cancer recurrence on B-mode ultrasonography underwent complementary power Doppler and SWE evaluations. Power Doppler morphologic criteria were classified as avascular, hypovascular, or hypervascular. Shear wave elastography was classified according to a 5-point scale (SWE score) and SWE maximum elasticity. Diagnostic accuracy was assessed by the sensitivity, specificity, and area under the curve. A decision curve analysis assessed clinical consequences of each method. The reference standard for diagnosis was defined as core needle or excisional biopsy. Histopathologic examinations revealed 9 (28.2%) benign and 23 (71.8%) malignant cases. Power Doppler ultrasonography (US) had sensitivity of 34.8% (95% confidence interval [CI], 6.6%-62.9%) and specificity of 45.4% (95% CI, 19.3%-71.5%). The SWE score (≥3) had sensitivity of 87.0% (95% CI, 66.4%-97.2%) and specificity of 44.4% (95% CI, 13.7%-78.8%). The SWE maximum elasticity (velocity > 6.5cm/s) had sensitivity of 87% (95% CI, 66.4%-97.2%) and specificity of 77.8% (95% CI, 40.0% to 97.2%). The areas under the curves for the SWE score and SWE maximum elasticity were 0.71 (95% CI, 0.53-0.87) and 0.82 (95% CI, 0.64-0.93), respectively (P = .32). Power Doppler US is unsuitable for discrimination between local breast cancer recurrence and fibrosis. Although the SWE score and SWE maximum elasticity can make this discrimination, the use of these methods to determine biopsy may lead to poorer clinical outcomes than the current practice of performing biopsies of all suspicious masses. © 2017 by the American Institute of Ultrasound in Medicine.

Changes in cochlear blood flow in mice due to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry.

PubMed

Reif, Roberto; Zhi, Zhongwei; Dziennis, Suzan; Nuttall, Alfred L; Wang, Ruikang K

2013-10-01

In this work we determined the contributions of loud sound exposure (LSE) on cochlear blood flow (CoBF) in an in vivo anesthetized mouse model. A broadband noise system (20 kHz bandwidth) with an intensity of 119 dB SPL, was used for a period of one hour to produce a loud sound stimulus. Two techniques were used to study the changes in blood flow, a Doppler optical microangiography (DOMAG) system; which can measure the blood flow within individual cochlear vessels, and a laser Doppler flowmetry (LDF) system; which averages the blood flow within a volume (a hemisphere of ~1.5 mm radius) of tissue. Both systems determined that the blood flow within the cochlea is reduced due to the LSE stimulation.

Contrast-enhanced magnetic resonance angiography for preoperative imaging of deep inferior epigastric artery perforator flaps: advantages and disadvantages compared with computed tomography angiography: a United Kingdom perspective.

PubMed

Schaverien, Mark V; Ludman, Catherine N; Neil-Dwyer, Jason; McCulley, Stephen J

2011-12-01

The anatomy of the anterior abdominal wall is highly variable and leads to uncertainty when harvesting a deep inferior epigastric artery perforator flap. Presurgical imaging has been shown to reduce the operating time, as well as reduce the rates of flap and donor site complications. The importance of imaging of the venous system has also been recognized for reducing the risk of venous congestion. The modalities currently available for presurgical imaging include handheld Doppler ultrasound, duplex ultrasound, computed tomographic angiography (CTA), and contrast-enhanced magnetic resonance angiography (CE-MRA). Of these, the most promising are CTA and CE-MRA, and advantages and disadvantages exist for both modalities. In this article, we review the use of CE-MRA for preoperative flap imaging and report our experience with its use in deep inferior epigastric artery perforator flap harvest, as well as compare it with CTA. We also explore the future directions for presurgical flap imaging.

Imaging the cool stars in the interacting binaries AE Aqr, BV Cen and V426 Oph

NASA Astrophysics Data System (ADS)

Watson, C. A.; Steeghs, D.; Dhillon, V. S.; Shahbaz, T.

2007-10-01

It is well known that magnetic activity in late-type stars increases with increasing rotation rate. Using inversion techniques akin to medical imaging, the rotationally broadened profiles from such stars can be used to reconstruct `Doppler images' of the distribution of cool, dark starspots on their stellar surfaces. Interacting binaries, however, contain some of the most rapidly rotating late-type stars known and thus provide important tests of stellar dynamo models. Furthermore, magnetic activity is thought to play a key role in their evolution, behaviour and accretion dynamics. Despite this, we know comparatively little about the magnetic activity and its influence on such binaries. In this review we summarise the concepts behind indirect imaging of these systems, and present movies of the starspot distributions on the cool stars in some interacting binaries. We conclude with a look at the future opportunities that such studies may provide.

The EDOP radar system on the high-altitude NASA ER-2 aircraft

USGS Publications Warehouse

Heymsfield, G.M.; Bidwell, S.W.; Caylor, I.J.; Ameen, S.; Nicholson, S.; Boncyk, W.; Miller, L.; Vandemark, D.; Racette, P.E.; Dod, L.R.

1996-01-01

The NASA ER-2 high-altitude (20 km) aircraft that emulates a satellite view of precipitation systems carries a variety of passive and active (lidar) remote sensing instruments. A new Doppler weather radar system at X band (9.6 GHz) called the ER-2 Doppler radar (EDOP) has been developed and flown on the ER-2 aircraft. EDOP is a fully coherent Doppler weather radar with fixed nadir and forward pointing (33?? off nadir) beams that map out Doppler winds and reflectivities in the vertical plane along the aircraft motion vector. Doppler winds from the two beams can be used to derive vertical and along-track air motions. In addition, the forward beam provides linear depolarization measurements that are useful in discriminating microphysical characteristics of the precipitation. This paper deals with a general description of the EDOP instrument including the measurement concept, the system configuration and hardware, and recently obtained data examples from the instrument. The combined remote sensing package on the ER-2, along with EDOP, provides a unique platform for simulating spaceborne remote sensing of precipitation.

Role of ultrasonography with color-Doppler in the emergency diagnosis of acute penile fracture: a case report.

PubMed

Buyukkaya, Ramazan; Buyukkaya, Ayla; Ozturk, Beyhan; Kayıkçı, Ali; Yazgan, Ömer

2014-03-01

Penile fracture is the rupture of tunica albuginea, typically resulting from blunt trauma, intercourse, or penile manipulation. Diagnosis is made clinically. Ultrasound is not used frequently in diagnosis of penile fracture but it provides a fast, non-invasive alternative to more often used MRI and cavernography. We aimed to present diagnostic ultrasound and color Doppler images of a patient with acute penile fracture in conjunction with literature.

US imaging and color Doppler in patients undergoing inhibitory therapy with calcitriol for secondary hyperparathyroidism.

PubMed

Pretolesi, F; Silvestri, E; Di Maio, G; Martinoli, C; Onetto, F; Sala, P; Derchi, L E

1997-01-01

The aim of this study was to evaluate the changes in volume, structure, and flow pattern of parathyroid glands in uremic patients with secondary hyperparathyroidism treated with long-term intravenous calcitriol (CTL) therapy. Ultrasonography was used to follow-up volume changes occurring in 18 enlarged glands in 11 patients during an 18-month period; in 6 of these cases, 11 glands were followed-up also with color-Doppler to monitor variations in flow pattern. Vascularization was classified using three grades: grade 0 = no color signal; grade I = vessels covering less than 50 % of glandular cross-sectional area; grade II = vascular signals covering more than 50 % of glandular cross-sectional area. No significant changes in volume were demonstrated during the 18 months of follow-up. On the contrary, significant decrease in flow was observed with almost complete disappearance of color-Doppler signals. This finding related well with the observed decrease in parathormone blood levels. Lack of volume changes during medical therapy demonstrates the inability of US alone to monitor the effect of this treatment on the parathyroid glands. Conversely, the observed intraglandular flow reduction indicates the possibility to use color Doppler to monitor the effects of CLT in uremic hemodialyzed patients with secondary hyperparathyroidism. This imaging procedure can be proposed for follow-up of the response of the parathyroid glands to therapy.

The effect of ambient lighting on Laser Doppler Imaging of a standardized cutaneous injury model.

PubMed

Pham, Alan Chuong Q; Hei, Erik La; Harvey, John G; Holland, Andrew Ja

2017-01-01

The aim of this study was to investigate the potential confounding effects of four different types of ambient lighting on the results of Laser Doppler Imaging (LDI) of a standardized cutaneous injury model. After applying a mechanical stimulus to the anterior forearm of a healthy volunteer and inducing a wheal and arteriolar flare (the Triple response), we used a Laser Doppler Line Scanner (LDLS) to image the forearm under four different types of ambient lighting: light-emitting-diode (LED), compact fluorescent lighting (CFL), halogen, daylight, and darkness as a control. A spectrometer was used to measure the intensity of light energy at 785 nm, the wavelength used by the scanner for measurement under each type of ambient lighting. Neither the LED nor CFL bulbs emitted detectable light energy at a wavelength of 785 nm. The color-based representation of arbitrary perfusion unit (APU) values of the Triple response measured by the scanner was similar between darkness, LED, and CFL light. Daylight emitted 2 mW at 785 nm, with a slight variation tending more towards lower APU values compared to darkness. Halogen lighting emitted 6 mW of light energy at 785 nm rendering the color-based representation impossible to interpret. Halogen lighting and daylight have the potential to confound results of LDI of cutaneous injuries whereas LED and CFL lighting did not. Any potential sources of daylight should be reduced and halogen lighting completely covered or turned off prior to wound imaging.

111-Indium platelet imaging, Doppler spectral analysis and angiography compared in patients with transient cerebral ischaemia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldman, M.; Leung, J.O.; Aukland, A.

An evaluation was made of carotid gamma imaging using /sup 111/Indium-labelled platelets in the diagnosis of carotid artery disease and measured the accumulation of labelled platelets was measured on endarterectomy specimens. Autologous /sup 111/In labelled platelets were injected in 25 patients with TIA. Gamma images were then taken daily and independently interpreted by two observers. Carotid endarterectomy was performed in 11 patients allowing measurement of the radioactivity on the operative specimen. These results were compared to the findings on angiography and Doppler spectral analysis. All endarterectomy specimens accumulated platelets with the most active equivalent to platelets from 1.8 ml blood.more » Atheromatous ulcers were more active than stenoses with mean (+/- SEM) activities of 1.12 +/- 0.37 and 0.38 +/- 0.10 respectively. These radioactivity levels were at the threshold of gamma camera resolution in a theoretical model. Both observers agreed that 22 of the 50 carotid bifurcations showed platelet accumulation on gamma imaging. Of the 12 atheromatous ulcers demonstrated by angiography 11 were visualized, but only five of ten stenoses greater than 80% were detected. As Doppler identified all stenoses only one angiographically diseased carotid was not detected by combining ultrasound with platelet scanning. Atherosclerotic arteries accumulate /sup 111/In platelets and the more thrombogenic ulcerated plaques are identified more frequently than stenoses. Long-term follow-up is required to establish the clinical relevance of platelet deposition.« less

Corkscrew Collateral Vessels in Buerger Disease: Vasa Vasorum or Vasa Nervorum.

PubMed

Baş, Ahmet; Dikici, Atilla S; Gülşen, Fatih; Samancı, Cesur; Mihmanlı, İsmail; Beşirli, Kazım; Numan, Furuzan; Kantarci, Fatih

2016-05-01

To investigate the origin of "corkscrew" collateral vessels around the occluded popliteal artery in patients with Buerger disease by Doppler ultrasound (US) and magnetic resonance (MR) imaging in tandem with digital subtraction angiography (DSA). Between January 2013 and June 2015, 42 patients diagnosed with Buerger disease were identified retrospectively. Patients in whom occlusion of the popliteal artery was found on DSA of the lower extremity were subjected to Doppler US and MR imaging prospectively. Fifteen of 42 patients were identified as having the required characteristics, of whom 10 participated in the present study. Ten patients with occlusion of the popliteal artery were selected for inclusion, and 12 lower limbs of these patients were investigated. The study cohort comprised one woman and nine men with a mean age of 41 years ± 10 (standard deviation; range, 39-58 y). Corkscrew collateral vessels identified on DSA examinations were also identified on secondary imaging (Doppler US and MR imaging) in all patients except one in whom the popliteal artery was reconstituted after short-segment occlusion. The origin of the corkscrew collateral vessels was identified as the vasa nervorum of the tibial nerve in nine patients. Data from the present study suggest that corkscrew collateral vessels at the knee level in patients with Buerger disease originate from the vasa nervorum of the tibial nerve rather than the vasa vasorum of the popliteal artery if the latter is occluded. Copyright © 2016 SIR. Published by Elsevier Inc. All rights reserved.

Left ventricular diastolic dysfunction without left ventricular hypertrophy in obese children and adolescents: a Tissue Doppler Imaging and Cardiac Troponin I Study.

PubMed

El Saiedi, Sonia A; Mira, Marwa F; Sharaf, Sahar A; Al Musaddar, Maysoun M; El Kaffas, Rania M H; AbdelMassih, Antoine F; Barsoum, Ihab H Y

2018-01-01

Obesity increases the risk for various cardiovascular problems. Increase in body mass index is often an independent risk factor for the development of elevated blood pressure and clustering of various cardiovascular risk factors. To determine early markers of left ventricular affection in obese patients before the appearance of left ventricular hypertrophy. In this cross-sectional study, we evaluated 42 obese patients and 30 healthy controls. Their ages ranged from 6 to 19 years. Studied children were subjected to anthropometric, lipid profile, and serum Troponin I level measurements. Echocardiographic evaluation performed to assess the left ventricle included left ventricular dimension measurement using motion-mode echocardiography, based on which patients with left ventricular hypertrophy (10 patients) were eliminated, as well as conventional and tissue Doppler imaging. Tissue Doppler findings in the study groups showed that the ratio of transmitral early diastolic filling velocity to septal peak early diastolic myocardial velocity (E/e') was significantly higher in cases compared with controls [6.9±1.4 versus 9.0±1.6, p (Pearson's coefficient)=0.001, respectively]. The level of cardiac troponin I was significantly higher in cases compared with controls [0.14±0.39 ng/ml versus 0.01±0.01 ng/ml, p (Pearson's coefficient)=0.047, respectively] and there was a significant correlation between troponin I and transmitral early diastolic filling velocity to septal peak early diastolic myocardial velocity ratio (E/e') [R (correlation coefficient)=0.6]. Tissue Doppler Imaging and Troponin I evaluation proved useful tools to detect early affection of the left ventricle in obese patients even in the absence of left ventricular hypertrophy.

Quantitation of stress echocardiography by tissue Doppler and strain rate imaging: a dream come true?

PubMed

Galderisi, Maurizio; Mele, Donato; Marino, Paolo Nicola

2005-01-01

Tissue Doppler (TD) is an ultrasound tool providing a quantitative agreement of left ventricular regional myocardial function in different modalities. Spectral pulsed wave (PW) TD, performed online during the examination, measures instantaneous myocardial velocities. By means of color TD, velocity images are digitally stored for subsequent off-line analysis and mean myocardial velocities are measured. An implementation of color TD includes strain rate imaging (SRI), based on post-processing conversion of regional velocities in local myocardial deformation rate (strain rate) and percent deformation (strain). These three modalities have been applied to stress echocardiography for quantitative evaluation of regional left ventricular function and detection of ischemia and viability. They present advantages and limitations. PWTD does not permit the simultaneous assessment of multiple walls and therefore is not compatible with clinical stress echocardiography while it could be used in a laboratory setting. Color TD provides a spatial map of velocity throughout the myocardium but its results are strongly affected by the frame rate. Both color TD and PWTD are also influenced by overall cardiac motion and tethering from adjacent segments and require reference velocity values for interpretation of regional left ventricular function. High frame rate (i.e. > 150 ms) post-processing-derived SRI can potentially overcome these limitations, since measurements of myocardial deformation have not any significant apex-to-base gradient. Preliminary studies have shown encouraging results about the ability of SRI to detect ischemia and viability, in terms of both strain rate changes and/or evidence of post-systolic thickening. SRI is, however, Doppler-dependent and time-consuming. Further technical refinements are needed to improve its application and introduce new ultrasound modalities to overcome the limitations of the Doppler-derived deformation analysis.

Bone surface enhancement in ultrasound images using a new Doppler-based acquisition/processing method.

PubMed

Yang, Xu; Tang, Songyuan; Tasciotti, Ennio; Righetti, Raffaella

2018-01-17

Ultrasound (US) imaging has long been considered as a potential aid in orthopedic surgeries. US technologies are safe, portable and do not use radiations. This would make them a desirable tool for real-time assessment of fractures and to monitor fracture healing. However, image quality of US imaging methods in bone applications is limited by speckle, attenuation, shadow, multiple reflections and other imaging artifacts. While bone surfaces typically appear in US images as somewhat 'brighter' than soft tissue, they are often not easily distinguishable from the surrounding tissue. Therefore, US imaging methods aimed at segmenting bone surfaces need enhancement in image contrast prior to segmentation to improve the quality of the detected bone surface. In this paper, we present a novel acquisition/processing technique for bone surface enhancement in US images. Inspired by elastography and Doppler imaging methods, this technique takes advantage of the difference between the mechanical and acoustic properties of bones and those of soft tissues to make the bone surface more easily distinguishable in US images. The objective of this technique is to facilitate US-based bone segmentation methods and improve the accuracy of their outcomes. The newly proposed technique is tested both in in vitro and in vivo experiments. The results of these preliminary experiments suggest that the use of the proposed technique has the potential to significantly enhance the detectability of bone surfaces in noisy ultrasound images.

Bone surface enhancement in ultrasound images using a new Doppler-based acquisition/processing method

NASA Astrophysics Data System (ADS)

Yang, Xu; Tang, Songyuan; Tasciotti, Ennio; Righetti, Raffaella

2018-01-01

Ultrasound (US) imaging has long been considered as a potential aid in orthopedic surgeries. US technologies are safe, portable and do not use radiations. This would make them a desirable tool for real-time assessment of fractures and to monitor fracture healing. However, image quality of US imaging methods in bone applications is limited by speckle, attenuation, shadow, multiple reflections and other imaging artifacts. While bone surfaces typically appear in US images as somewhat ‘brighter’ than soft tissue, they are often not easily distinguishable from the surrounding tissue. Therefore, US imaging methods aimed at segmenting bone surfaces need enhancement in image contrast prior to segmentation to improve the quality of the detected bone surface. In this paper, we present a novel acquisition/processing technique for bone surface enhancement in US images. Inspired by elastography and Doppler imaging methods, this technique takes advantage of the difference between the mechanical and acoustic properties of bones and those of soft tissues to make the bone surface more easily distinguishable in US images. The objective of this technique is to facilitate US-based bone segmentation methods and improve the accuracy of their outcomes. The newly proposed technique is tested both in in vitro and in vivo experiments. The results of these preliminary experiments suggest that the use of the proposed technique has the potential to significantly enhance the detectability of bone surfaces in noisy ultrasound images.

Microvascular anastomosis guidance and evaluation using real-time three-dimensional Fourier-domain Doppler optical coherence tomography

PubMed Central

Ibrahim, Zuhaib; Tong, Dedi; Zhu, Shan; Mao, Qi; Pang, John; Andrew Lee, Wei Ping; Brandacher, Gerald; Kang, Jin U.

2013-01-01

Abstract. Vascular and microvascular anastomoses are critical components of reconstructive microsurgery, vascular surgery, and transplant surgery. Intraoperative surgical guidance using a surgical imaging modality that provides an in-depth view and three-dimensional (3-D) imaging can potentially improve outcome following both conventional and innovative anastomosis techniques. Objective postoperative imaging of the anastomosed vessel can potentially improve the salvage rate when combined with other clinical assessment tools, such as capillary refill, temperature, blanching, and skin turgor. Compared to other contemporary postoperative monitoring modalities—computed tomography angiograms, magnetic resonance (MR) angiograms, and ultrasound Doppler—optical coherence tomography (OCT) is a noninvasive high-resolution (micron-level), high-speed, 3-D imaging modality that has been adopted widely in biomedical and clinical applications. For the first time, to the best of our knowledge, the feasibility of real-time 3-D phase-resolved Doppler OCT (PRDOCT) as an assisted intra- and postoperative imaging modality for microvascular anastomosis of rodent femoral vessels is demonstrated, which will provide new insights and a potential breakthrough to microvascular and supermicrovascular surgery. PMID:23856833

Motion Tolerant Unfocused Imaging of Physiological Waveforms for Blood Pressure Waveform Estimation Using Ultrasound.

PubMed

Seo, Joohyun; Pietrangelo, Sabino J; Sodini, Charles G; Lee, Hae-Seung

2018-05-01

This paper details unfocused imaging using single-element ultrasound transducers for motion tolerant arterial blood pressure (ABP) waveform estimation. The ABP waveform is estimated based on pulse wave velocity and arterial pulsation through Doppler and M-mode ultrasound. This paper discusses approaches to mitigate the effect of increased clutter due to unfocused imaging on blood flow and diameter waveform estimation. An intensity reduction model (IRM) estimator is described to track the change of diameter, which outperforms a complex cross-correlation model (C3M) estimator in low contrast environments. An adaptive clutter filtering approach is also presented, which reduces the increased Doppler angle estimation error due to unfocused imaging. Experimental results in a flow phantom demonstrate that flow velocity and diameter waveforms can be reliably measured with wide lateral offsets of the transducer position. The distension waveform estimated from human carotid M-mode imaging using the IRM estimator shows physiological baseline fluctuations and 0.6-mm pulsatile diameter change on average, which is within the expected physiological range. These results show the feasibility of this low cost and portable ABP waveform estimation device.

Radar velocity determination using direction of arrival measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doerry, Armin W.; Bickel, Douglas L.; Naething, Richard M.

The various technologies presented herein relate to utilizing direction of arrival (DOA) data to determine various flight parameters for an aircraft A plurality of radar images (e.g., SAR images) can be analyzed to identify a plurality of pixels in the radar images relating to one or more ground targets. In an embodiment, the plurality of pixels can be selected based upon the pixels exceeding a SNR threshold. The DOA data in conjunction with a measurable Doppler frequency for each pixel can be obtained. Multi-aperture technology enables derivation of an independent measure of DOA to each pixel based on interferometric analysis.more » This independent measure of DOA enables decoupling of the aircraft velocity from the DOA in a range-Doppler map, thereby enabling determination of a radar velocity. The determined aircraft velocity can be utilized to update an onboard INS, and to keep it aligned, without the need for additional velocity-measuring instrumentation.« less

Feasibility of transabdominal Doppler sonography for studying uterine blood flow characteristics in cycling gilts.

PubMed

Herlta, Catherine; Starka, Rosa; Sigmarsson, Haukur L; Kauffold, Johannes

2018-06-01

To test for the feasibility of transabdominal Doppler sonography (color, power, pulse wave) to define uterine perfusion characteristics throughout the estrous cycle in gilts. A total of 15 gilts were synchronized for estrus and scanned in their following spontaneous cycle while being restrained in a purpose-designed mobile crate. To define uterine perfusion characteristics, vessels in between and within uterine cross-sections were imaged and recorded as video sequences to be analyzed by PixelFlux® software for perfused area (Amix), blood flow velocity (vmix) and intensity (Imix) as well as resistance (RIvmix) and pulsatility index (PIvmix). Color Doppler sonography proved to be the only feasible technique, as it was less affected by animal movements than power and pulse wave sonography. As determined by color Doppler sonography, all five parameters determined showed specific patterns through the estrous cycle, i. e. Amix, vmix, Imix were high in proestrus, decreased in estrus and remained low in midestrus and most parts of diestrus; RIvmix and PIvmix with inversely paralleled patterns. This study has demonstrated that transabdominal color Doppler but not power and pulse wave Doppler sonography is feasible to be performed in crate-restrained gilts for studying uterine perfusion characteristics during the estrous cycle, and that changes of uterine perfusion over the course of the estrous cycle can be clearly followed by color Doppler sonography. Results encourage the use of color Doppler sonography for studying i. e. uterine capacity or uterus related infertility such as for cases of clinically unapparent endometritis. Schattauer GmbH.

OCT methods for capillary velocimetry

PubMed Central

Srinivasan, Vivek J.; Radhakrishnan, Harsha; Lo, Eng H.; Mandeville, Emiri T.; Jiang, James Y.; Barry, Scott; Cable, Alex E.

2012-01-01

To date, two main categories of OCT techniques have been described for imaging hemodynamics: Doppler OCT and OCT angiography. Doppler OCT can measure axial velocity profiles and flow in arteries and veins, while OCT angiography can determine vascular morphology, tone, and presence or absence of red blood cell (RBC) perfusion. However, neither method can quantify RBC velocity in capillaries, where RBC flow is typically transverse to the probe beam and single-file. Here, we describe new methods that potentially address these limitations. Firstly, we describe a complex-valued OCT signal in terms of a static scattering component, dynamic scattering component, and noise. Secondly, we propose that the time scale of random fluctuations in the dynamic scattering component are related to red blood cell velocity. Analysis was performed along the slow axis of repeated B-scans to parallelize measurements. We correlate our purported velocity measurements against two-photon microscopy measurements of RBC velocity, and investigate changes during hypercapnia. Finally, we image the ischemic stroke penumbra during distal middle cerebral artery occlusion (dMCAO), where OCT velocimetry methods provide additional insight that is not afforded by either Doppler OCT or OCT angiography. PMID:22435106

Laser Doppler diagnostics for orthodontia

NASA Astrophysics Data System (ADS)

Ryzhkova, Anastasia V.; Lebedeva, Nina G.; Sedykh, Alexey V.; Ulyanov, Sergey S.; Lepilin, Alexander V.; Kharish, Natalia A.

2004-06-01

The results of statistical analysis of Doppler spectra of intensity fluctuations of light, scattered from mucous membrane of oral cavity of healthy volunteers and patients, abused by the orthodontic diseases, are presented. Analysis of Doppler spectra, obtained from tooth pulp of patients, is carried out. New approach to monitoring of blood microcirculation in orthodontics is suggested. Influence of own noise of Doppler measuring system on formation of the output signal is studied.

Medical application of artificial immune recognition system (AIRS): diagnosis of atherosclerosis from carotid artery Doppler signals.

PubMed

Latifoğlu, Fatma; Kodaz, Halife; Kara, Sadik; Güneş, Salih

2007-08-01

This study was conducted to distinguish between atherosclerosis and healthy subjects. Hence, we have employed the maximum envelope of the carotid artery Doppler sonograms derived from Fast Fourier Transformation-Welch method and Artificial Immune Recognition System (AIRS). The fuzzy appearance of the carotid artery Doppler signals makes physicians suspicious about the existence of diseases and sometimes causes false diagnosis. Our technique gets around this problem using AIRS to decide and assist the physician to make the final judgment in confidence. AIRS has reached 99.29% classification accuracy using 10-fold cross validation. Results show that the proposed method classified Doppler signals successfully.

A comparison of a coaxial focused laser Doppler system in atmospheric measurements

NASA Technical Reports Server (NTRS)

Karaki, S.

1973-01-01

Measurements of atmospheric velocities and turbulence with the laser Doppler system were obtained, and the results compared with cup anemometer and hot-wire measurements in the same wind field. The laser Doppler velocimeter (LDV) is described along with the test procedures. It was found that mean values determined from the LDV data are within 5% of other anemometer data for long time periods, and the LDV measures higher velocities.

PACS and teleradiology for on-call support of abdominal imaging

NASA Astrophysics Data System (ADS)

Horii, Steven C.; Garra, Brian S.; Mun, Seong K.; Zeman, Robert K.; Levine, Betty A.; Fielding, Robert

1991-07-01

One aspect of the Georgetown image management and communications system (IMACS or PACS) is a built-in capability to support teleradiology. Unlike many dedicated teleradiology systems, the support of this capability as a part of PACS means that any acquired images are remotely accessible, not just those specifically input for transmission. Over the past one and one-half years, two radiologists (SCH, BSG) in the abdominal imaging division of the department of radiology have been accumulating experience with teleradiology for on-call support of emergency abdominal imaging, chiefly in ultrasound. As of the time of this writing, use of the system during on-call (one of these attending radiologists primarily responsible) or back-up call (the attending responsible for the Fellow on primary call) has resulted in a marked reduction in the number of times one of them has to drive to the hospital at night or over the weekend. Approximately 80% of the time, use of the teleradiology system obviates having to go in to review a case. The remainder of the time, the radiologist has to perform a procedure (e.g., abscess drainage) or a scan (e.g., complex Doppler study) himself. This paper reviews the system used for teleradiology, how it is electronically and operationally integrated with the PACS, the clinical benefits and disadvantages of this use, and radiologist and referring physician acceptance.

Doppler-shifted fluorescence imaging of velocity fields in supersonic reacting flows

NASA Technical Reports Server (NTRS)

Allen, M. G.; Davis, S. J.; Kessler, W. J.; Sonnenfroh, D. M.

1992-01-01

The application of Doppler-shifted fluorescence imaging of velocity fields in supersonic reacting flows is analyzed. Focussing on fluorescence of the OH molecule in typical H2-air Scramjet flows, the effects of uncharacterized variations in temperature, pressure, and collisional partner composition across the measurement plane are examined. Detailed measurements of the (1,0) band OH lineshape variations in H2-air combustions are used, along with single-pulse and time-averaged measurements of an excimer-pumped dye laser, to predict the performance of a model velocimeter with typical Scramjet flow properties. The analysis demonstrates the need for modification and control of the laser bandshape in order to permit accurate velocity measurements in the presence of multivariant flow properties.

Ultrasonically Encoded Photoacoustic Flowgraphy in Biological Tissue

NASA Astrophysics Data System (ADS)

Wang, Lidai; Xia, Jun; Yao, Junjie; Maslov, Konstantin I.; Wang, Lihong V.

2013-11-01

Blood flow speed is an important functional parameter. Doppler ultrasound flowmetry lacks sufficient sensitivity to slow blood flow (several to tens of millimeters per second) in deep tissue. To address this challenge, we developed ultrasonically encoded photoacoustic flowgraphy combining ultrasonic thermal tagging with photoacoustic imaging. Focused ultrasound generates a confined heat source in acoustically absorptive fluid. Thermal waves propagate with the flow and are directly visualized in pseudo color using photoacoustic computed tomography. The Doppler shift is employed to calculate the flow speed. This method requires only acoustic and optical absorption, and thus is applicable to continuous fluid. A blood flow speed as low as 0.24mm·s-1 was successfully measured. Deep blood flow imaging was experimentally demonstrated under 5-mm-thick chicken breast tissue.

Mobile Laser Doppler System Checkout and Calibration : Volume 1. Text

DOT National Transportation Integrated Search

1977-06-01

A program has been carried out to make modifications to the Lockheed-Huntsville Mobiel Laser Doppler Velocimeter(LDV)system; to calibrate and operate the system at the John F. Kennedy (JFK) Airport; to obtain a data base of wind, wind shear, and wake...

Mobile Laser Doppler System Checkout and Calibration : Volume 2. Appendixes.

DOT National Transportation Integrated Search

1977-06-01

A program has been carried out to make modifications to the Lockheed-Huntsville Mobiel Laser Doppler Velocimeter(LDV)system; to calibrate and operate the system at the John F. Kennedy (JFK) Airport; to obtain a data base of wind, wind shear, and wake...

Does ketogenic diet have any negative effect on cardiac systolic and diastolic functions in children with intractable epilepsy?: One-year follow-up results.

PubMed

Ozdemir, Rahmi; Kucuk, Mehmet; Guzel, Orkide; Karadeniz, Cem; Yilmaz, Unsal; Mese, Timur

2016-10-01

The ketogenic diet (KD) has been referred to as an "effective therapy with side effects" for children with intractable epilepsy. Among the most recognized adverse effects, there are cardiac conduction abnormalities, vascular and myocardial dysfunction. However, very limited and controversial data are available regarding the effects of the KD on cardiac functions. We sought to analyze the mid-term effect of ketogenic diet on cardiac functions in patients with intractable epilepsy who received a ketogenic diet for at least 12months using conventional and relatively new imaging techniques. This prospective study included 61 patients with intractable epilepsy who received ketogenic diet for at least 12months. Clinical examinations, serum carnitine and selenium levels as well as electrocardiographic and echocardiographic examinations were scheduled prior to the procedure and at 1, 3, 6 and 12months. We utilized two-dimensional, M-mode, colored Doppler, spectral Doppler and pulsed wave tissue Doppler imaging techniques to investigate ventricular systolic and diastolic functions of this subgroup of patients. In our study, there was no significant difference after 1year of KD therapy compared to baseline values-except a significantly decreased A wave velocity-in terms of pulse wave Doppler echocardiographic measurements of the diastolic function. The tissue Doppler measurements obtained from the lateral wall of tricuspide and mitral annuli were not different at baseline and at month 12 of the treatment, as well. The ketogenic diet appears to have no disturbing effect on ventricular functions in epileptic children in the midterm. Copyright © 2016 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

Evaluation of dynamic infrared thermography as an alternative to CT angiography for perforator mapping in breast reconstruction: a clinical study.

PubMed

Weum, Sven; Mercer, James B; de Weerd, Louis

2016-07-15

The current gold standard for preoperative perforator mapping in breast reconstruction with a DIEP flap is CT angiography (CTA). Dynamic infrared thermography (DIRT) is an imaging method that does not require ionizing radiation or contrast injection. We evaluated if DIRT could be an alternative to CTA in perforator mapping. Twenty-five patients scheduled for secondary breast reconstruction with a DIEP flap were included. Preoperatively, the lower abdomen was examined with hand-held Doppler, DIRT and CTA. Arterial Doppler sound locations were marked on the skin. DIRT examination involved rewarming of the abdominal skin after a mild cold challenge. The locations of hot spots on DIRT were compared with the arterial Doppler sound locations. The rate and pattern of rewarming of the hot spots were analyzed. Multiplanar CT reconstructions were used to see if hot spots were related to perforators on CTA. All flaps were based on the perforator selected with DIRT and the surgical outcome was analyzed. First appearing hot spots were always associated with arterial Doppler sounds and clearly visible perforators on CTA. The hot spots on DIRT images were always slightly laterally located in relation to the exit points of the associated perforators through the rectus abdominis fascia on CTA. Some periumbilical perforators were not associated with hot spots and showed communication with the superficial inferior epigastric vein on CTA. The selected perforators adequately perfused all flaps. This study confirms that perforators selected with DIRT have arterial Doppler sound, are clearly visible on CTA and provide adequate perfusion for DIEP breast reconstruction. Retrospectively registered at ClinicalTrials.gov with identifier NCT02806518 .

Design and Development of a Scanning Airborne Direct Detection Doppler Lidar System

NASA Technical Reports Server (NTRS)

Gentry, Bruce; McGill, Matthew; Schwemmer, Geary; Hardesty, Michael; Brewer, Alan; Wilkerson, Thomas; Atlas, Robert; Sirota, Marcos; Lindemann, Scott

2006-01-01

In the fall of 2005 we began developing an airborne scanning direct detection molecular Doppler lidar. The instrument is being built as part of the Tropospheric Wind Lidar Technology Experiment (TWiLiTE), a three year project selected by the NASA Earth Sun Technology Office under the Instrument Incubator Program. The TWiLiTE project is a collaboration involving scientists and engineers from NASA Goddard Space Flight Center, NOAA ESRL, Utah State University Space Dynamics Lab, Michigan Aerospace Corporation and Sigma Space Corporation. The TWiLiTE instrument will leverage significant research and development investments made by NASA Goddard and it's partners in the past several years in key lidar technologies and sub-systems (lasers, telescopes, scanning systems, detectors and receivers) required to enable spaceborne global wind lidar measurement. These sub-systems will be integrated into a complete molecular direct detection Doppler wind lidar system designed for autonomous operation on a high altitude aircraft, such as the NASA WB57. The WB57 flies at an altitude of 18 km and from this vantage point the nadir viewing Doppler lidar will be able to profile winds through the full troposphere. The TWiLiTE integrated airborne Doppler lidar instrument will be the first demonstration of a airborne scanning direct detection Doppler lidar and will serve as a critical milestone on the path to a future spaceborne tropospheric wind system. In addition to being a technology testbed for space based tropospheric wind lidar, when completed the TWiLiTE high altitude airborne lidar will be used for studying mesoscale dynamics and storm research (e.g. winter storms, hurricanes) and could be used for calibration and validation of satellite based wind systems such as ESA's Aeolus Atmospheric Dynamics Mission. The TWiLiTE Doppler lidar will have the capability to profile winds in clear air from the aircraft altitude of 18 km to the surface with 250 m vertical resolution and < 2mls velocity accuracy.

Visualization of chorioretinal vasculature in mice in vivo using a combined OCT/SLO imaging system

NASA Astrophysics Data System (ADS)

Goswami, Mayank; Zhang, Pengfei; Pugh, Edward N.; Zawadzki, Robert J.

2016-03-01

Chorioretinal blood vessel morphology in mice is of great interest to researchers studying eye disease mechanisms in animal models. Two leading retinal imaging modalities -- Optical Coherence Tomography (OCT) and Scanning Laser Ophthalmoscopy (SLO) -- have offered much insight into vascular morphology and blood flow. OCT "flow-contrast" methods have provided detailed mapping of vascular morphology with micrometer depth resolution, while OCT Doppler methods have enabled the measurement of local flow velocities. SLO remains indispensable in studying blood leakage, microaneurysms, and the clearance time of contrast agents of different sizes. In this manuscript we present results obtained with a custom OCT/SLO system applied to visualize the chorioretinal vascular morphology of pigmented C57Bl/6J and albino nude (Nu/Nu) mice. Blood perfusion maps of choroidal vessels and choricapillaris created by OCT and SLO are presented, along with detailed evaluation of different OCT imaging parameters, including the use of the scattering contrast agent Intralipid. Future applications are discussed.

Simulation of a Doppler lidar system for autonomous navigation and hazard avoidance during planetary landing

NASA Astrophysics Data System (ADS)

Budge, Scott E.; Chester, David B.

2016-05-01

The latest mission proposals for exploration of solar system bodies require accurate position and velocity data during the descent phase in order to ensure safe, soft landing at the pre-designated sites. During landing maneuvers, the accuracy of the on-board inertial measurement unit (IMU) may not be reliable due to drift over extended travel times to destinations. NASA has proposed an advanced Doppler lidar system with multiple beams that can be used to accurately determine attitude and position of the landing vehicle during descent, and to detect hazards that might exist in the landing area. In order to assess the effectiveness of such a Doppler lidar landing system, it is valuable to simulate the system with different beam numbers and configurations. In addition, the effectiveness of the system to detect and map potential landing hazards must be understood. This paper reports the simulated system performance for a proposed multi-beam Doppler lidar using the LadarSIM system simulation software. Details of the simulation methods are given, as well as lidar performance parameters such as range and velocity accuracy, detection and false alarm rates, and examples of the Doppler lidars ability to detect and characterize simulated hazards in the landing site. The simulation includes modulated pulse generation and coherent detection methods, beam footprint simulation, beam scanning, and interaction with terrain.

An Acoustic OFDM System with Symbol-by-Symbol Doppler Compensation for Underwater Communication

PubMed Central

MinhHai, Tran; Rie, Saotome; Suzuki, Taisaku; Wada, Tomohisa

2016-01-01

We propose an acoustic OFDM system for underwater communication, specifically for vertical link communications such as between a robot in the sea bottom and a mother ship in the surface. The main contributions are (1) estimation of time varying Doppler shift using continual pilots in conjunction with monitoring the drift of Power Delay Profile and (2) symbol-by-symbol Doppler compensation in frequency domain by an ICI matrix representing nonuniform Doppler. In addition, we compare our proposal against a resampling method. Simulation and experimental results confirm that our system outperforms the resampling method when the velocity changes roughly over OFDM symbols. Overall, experimental results taken in Shizuoka, Japan, show our system using 16QAM, and 64QAM achieved a data throughput of 7.5 Kbit/sec with a transmitter moving at maximum 2 m/s, in a complicated trajectory, over 30 m vertically. PMID:27057558

Imaging photoplethysmography for clinical assessment of cutaneous microcirculation at two different depths

NASA Astrophysics Data System (ADS)

Marcinkevics, Zbignevs; Rubins, Uldis; Zaharans, Janis; Miscuks, Aleksejs; Urtane, Evelina; Ozolina-Moll, Liga

2016-03-01

The feasibility of bispectral imaging photoplethysmography (iPPG) system for clinical assessment of cutaneous microcirculation at two different depths is proposed. The iPPG system has been developed and evaluated for in vivo conditions during various tests: (1) topical application of vasodilatory liniment on the skin, (2) skin local heating, (3) arterial occlusion, and (4) regional anesthesia. The device has been validated by the measurements of a laser Doppler imager (LDI) as a reference. The hardware comprises four bispectral light sources (530 and 810 nm) for uniform illumination of skin, video camera, and the control unit for triggering of the system. The PPG signals were calculated and the changes of perfusion index (PI) were obtained during the tests. The results showed convincing correlations for PI obtained by iPPG and LDI at (1) topical liniment (r=0.98) and (2) heating (r=0.98) tests. The topical liniment and local heating tests revealed good selectivity of the system for superficial microcirculation monitoring. It is confirmed that the iPPG system could be used for assessment of cutaneous perfusion at two different depths, morphologically and functionally different vascular networks, and thus utilized in clinics as a cost-effective alternative to the LDI.

Imaging photoplethysmography for clinical assessment of cutaneous microcirculation at two different depths.

PubMed

Marcinkevics, Zbignevs; Rubins, Uldis; Zaharans, Janis; Miscuks, Aleksejs; Urtane, Evelina; Ozolina-Moll, Liga

2016-03-01

The feasibility of bispectral imaging photoplethysmography (iPPG) system for clinical assessment of cutaneous microcirculation at two different depths is proposed. The iPPG system has been developed and evaluated for in vivo conditions during various tests: (1) topical application of vasodilatory liniment on the skin, (2) skin local heating, (3) arterial occlusion, and (4) regional anesthesia. The device has been validated by the measurements of a laser Doppler imager (LDI) as a reference. The hardware comprises four bispectral light sources (530 and 810 nm) for uniform illumination of skin, video camera, and the control unit for triggering of the system. The PPG signals were calculated and the changes of perfusion index (PI) were obtained during the tests. The results showed convincing correlations for PI obtained by iPPG530 nm and LDI at (1) topical liniment (r = 0.98) and (2) heating (r = 0.98) tests. The topical liniment and local heating tests revealed good selectivity of the system for superficial microcirculation monitoring. It is confirmed that the iPPG system could be used for assessment of cutaneous perfusion at two different depths, morphologically and functionally different vascular networks, and thus utilized in clinics as a cost-effective alternative to the LDI.

Doppler-Only Synthetic Aperture Radar

DTIC Science & Technology

2006-12-01

5 B. TARGET RECOGNITION TECHNIQUES .................................................6 1. Cooperative Targets...6 3. Techniques ............................................................................................6 C. TARGET RECOGNITION...3. Implementation of High Range Resolution Techniques .................12 F. TWO-DIMENSIONAL IMAGING

ImSyn: photonic image synthesis applied to synthetic aperture radar, microscopy, and ultrasound imaging

NASA Astrophysics Data System (ADS)

Turpin, Terry M.; Lafuse, James L.

1993-02-01

ImSynTM is an image synthesis technology, developed and patented by Essex Corporation. ImSynTM can provide compact, low cost, and low power solutions to some of the most difficult image synthesis problems existing today. The inherent simplicity of ImSynTM enables the manufacture of low cost and reliable photonic systems for imaging applications ranging from airborne reconnaissance to doctor's office ultrasound. The initial application of ImSynTM technology has been to SAR processing; however, it has a wide range of applications such as: image correlation, image compression, acoustic imaging, x-ray tomographic (CAT, PET, SPECT), magnetic resonance imaging (MRI), microscopy, range- doppler mapping (extended TDOA/FDOA). This paper describes ImSynTM in terms of synthetic aperture microscopy and then shows how the technology can be extended to ultrasound and synthetic aperture radar. The synthetic aperture microscope (SAM) enables high resolution three dimensional microscopy with greater dynamic range than real aperture microscopes. SAM produces complex image data, enabling the use of coherent image processing techniques. Most importantly SAM produces the image data in a form that is easily manipulated by a digital image processing workstation.

An audit of a hospital-based Doppler ultrasound quality control protocol using a commercial string Doppler phantom.

PubMed

Cournane, S; Fagan, A J; Browne, J E

2014-05-01

Results from a four-year audit of a Doppler quality assurance (QA) program using a commercially available Doppler string phantom are presented. The suitability of the phantom was firstly determined and modifications were made to improve the reliability and quality of the measurements. QA of Doppler ultrasound equipment is very important as data obtained from these systems is used in patient management. It was found that if the braided-silk filament of the Doppler phantom was exchanged with an O-ring rubber filament and the velocity range below 50 cm/s was avoided for Doppler quality control (QC) measurements, then the maximum velocity accuracy (MVA) error and intrinsic spectral broadening (ISB) results obtained using this device had a repeatability of 18 ± 3.3% and 19 ± 3.5%, respectively. A consistent overestimation of the MVA of between 12% and 56% was found for each of the tested ultrasound systems. Of more concern was the variation of the overestimation within each respective transducer category: MVA errors of the linear, curvilinear and phased array probes were in the range 12.3-20.8%, 32.3-53.8% and 27-40.7%, respectively. There is a dearth of QA data for Doppler ultrasound; it would be beneficial if a multicentre longitudinal study was carried out using the same Doppler ultrasound test object to evaluate sensitivity to deterioration in performance measurements. Copyright © 2013 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

NEXRAD

Science.gov Websites

images are available on the Internet from the NWS Homepage and local NWS Forecast Offices. NEXRAD Doppler Radar images may also be found on local cable channels and the Internet webpages of local media including TV stations, radio stations and newspapers as well as others. Use one of Internet search engines

Neurilemmoma of the glans penis: ultrasonography and magnetic resonance imaging findings.

PubMed

Jung, Dae Chul; Hwang, Sung Il; Jung, Sung Il; Kim, Sun Ho; Kim, Seung Hyup

2006-01-01

Neurilemmoma of the glans penis is rare, and no imaging findings have been reported. A case of neurilemmoma of the glans penis is presented. Ultrasonography (US) and magnetic resonance imaging revealed a well-defined small mass in the glans penis. The mass appeared hypoechoic on gray-scale US and hypervascular on color Doppler US. Magnetic resonance imaging revealed high signal intensity of the mass on a T2-weighted image and strong enhancement on a contrast-enhanced T1-weighted image.

Software For Clear-Air Doppler-Radar Display

NASA Technical Reports Server (NTRS)

Johnston, Bruce W.

1990-01-01

System of software developed to present plan-position-indicator scans of clear-air Doppler radar station on color graphical cathode-ray-tube display. Designed to incorporate latest accepted standards for equipment, computer programs, and meteorological data bases. Includes use of Ada programming language, of "Graphical-Kernel-System-like" graphics interface, and of Common Doppler Radar Exchange Format. Features include portability and maintainability. Use of Ada software packages produced number of software modules reused on other related projects.

Portable fiber optic coupled Doppler interferometer system for detonation and shock wave diagnostics

NASA Technical Reports Server (NTRS)

Fleming, Kevin J.

1993-01-01

Testing and analysis of shock wave characteristics such as detonators and ground shock propagation frequently require a method of measuring velocity and displacement of the surface of interest. One method of measurement is Doppler interferometry. The VISAR (Velocity Interferometer System for Any Reflector) uses Doppler interferometry and has gained wide acceptance as the preferred tool for shock measurement. An important asset of VISAR is that it measures velocity and displacement nonintrusively.

Architectures of planetary systems and implications for their formation.

PubMed

Ford, Eric B

2014-09-02

Doppler planet searches revealed that many giant planets orbit close to their host star or in highly eccentric orbits. These and subsequent observations inspired new theories of planet formation that invoke gravitation interactions in multiple planet systems to explain the excitation of orbital eccentricities and even short-period giant planets. Recently, NASA's Kepler mission has identified over 300 systems with multiple transiting planet candidates, including many potentially rocky planets. Most of these systems include multiple planets with closely spaced orbits and sizes between that of Earth and Neptune. These systems represent yet another new and unexpected class of planetary systems and provide an opportunity to test the theories developed to explain the properties of giant exoplanets. Presently, we have limited knowledge about such planetary systems, mostly about their sizes and orbital periods. With the advent of long-term, nearly continuous monitoring by Kepler, the method of transit timing variations (TTVs) has blossomed as a new technique for characterizing the gravitational effects of mutual planetary perturbations for hundreds of planets. TTVs can provide precise, but complex, constraints on planetary masses, densities, and orbits, even for planetary systems with faint host stars. In the coming years, astronomers will translate TTV observations into increasingly powerful constraints on the formation and orbital evolution of planetary systems with low-mass planets. Between TTVs, improved Doppler surveys, high-contrast imaging campaigns, and microlensing surveys, astronomers can look forward to a much better understanding of planet formation in the coming decade.

Architectures of planetary systems and implications for their formation

PubMed Central

Ford, Eric B.

2014-01-01

Doppler planet searches revealed that many giant planets orbit close to their host star or in highly eccentric orbits. These and subsequent observations inspired new theories of planet formation that invoke gravitation interactions in multiple planet systems to explain the excitation of orbital eccentricities and even short-period giant planets. Recently, NASA’s Kepler mission has identified over 300 systems with multiple transiting planet candidates, including many potentially rocky planets. Most of these systems include multiple planets with closely spaced orbits and sizes between that of Earth and Neptune. These systems represent yet another new and unexpected class of planetary systems and provide an opportunity to test the theories developed to explain the properties of giant exoplanets. Presently, we have limited knowledge about such planetary systems, mostly about their sizes and orbital periods. With the advent of long-term, nearly continuous monitoring by Kepler, the method of transit timing variations (TTVs) has blossomed as a new technique for characterizing the gravitational effects of mutual planetary perturbations for hundreds of planets. TTVs can provide precise, but complex, constraints on planetary masses, densities, and orbits, even for planetary systems with faint host stars. In the coming years, astronomers will translate TTV observations into increasingly powerful constraints on the formation and orbital evolution of planetary systems with low-mass planets. Between TTVs, improved Doppler surveys, high-contrast imaging campaigns, and microlensing surveys, astronomers can look forward to a much better understanding of planet formation in the coming decade. PMID:24778212

Patterns of left ventricular diastolic function in Olympic athletes.

PubMed

Caselli, Stefano; Di Paolo, Fernando M; Pisicchio, Cataldo; Pandian, Natesa G; Pelliccia, Antonio

2015-02-01

Whether morphologic left ventricular (LV) changes in elite athletes are associated with altered diastolic properties is undefined. The aim of this study was to investigate LV diastolic properties in a large population of Olympic athletes compared to untrained controls. A total of 1,145 Olympic athletes (61% men), and 154 controls, free of cardiovascular disease, underwent two-dimensional echocardiography, Doppler echocardiography, and Doppler tissue imaging. Athletes had similar E velocities (87 ± 15 vs 89 ± 16 cm/sec, P = .134) but significantly decreased A velocities (47 ± 10 vs 56 ± 12 cm/sec, P < .001) compared with controls, with increased E/A ratios (1.93 ± 0.50 vs 1.63 ± 0.35, P < .001) and values ranging up to 4.8. Isovolumic relaxation (83 ± 13 vs 71 ± 16 msec, P < .001) and deceleration times (203 ± 40 vs 181 ± 36 msec, P < .001) were longer in athletes compared with controls. Doppler tissue imaging e' (13.8 ± 2.2 vs 16.2 ± 3.7 cm/sec, P < .001) and a' (7.2 ± 1.8 vs 8.5 ± 2.1 cm/sec, P < .001) were lower in athletes than in controls, but their ratio was not different between groups; E/e' ratios (6.37 ± 1.2 vs 5.72 ± 1.33, P < .001) were mildly higher in athletes. Subgroup analysis for type of sport showed that endurance athletes had the lowest A and a' velocities and the largest E/A ratios. Gender analysis revealed that men had significantly lower E and A velocities, as well as e', e'/a' ratios, and E/e' ratios (P < .01), compared with women. This study provides normal values for Doppler echocardiographic and Doppler tissue imaging parameters describing diastolic function in elite athletes, which may be implemented as reference values in the clinical assessment of athlete's heart and prove useful in understanding the physiologic limits of cardiac adaptations in athletes. Copyright © 2015 American Society of Echocardiography. All rights reserved.

Coronary CT Angiography Incorporating Doppler-Guided Prospective ECG Gating in Patients with High Heart Rate: Comparison with Results of Traditional Prospective ECG Gating

PubMed Central

Li, Min; Yu, Bing-bing; Wu, Jian-hua; Xu, Lin; Sun, Gang

2013-01-01

Purpose As Doppler ultrasound has been proven to be an effective tool to predict and compress the optimal pulsing windows, we evaluated the effective dose and diagnostic accuracy of coronary CT angiography (CTA) incorporating Doppler-guided prospective electrocardiograph (ECG) gating, which presets pulsing windows according to Doppler analysis, in patients with a heart rate >65 bpm. Materials and Methods 119 patients with a heart rate >65 bpm who were scheduled for invasive coronary angiography were prospectively studied, and patients were randomly divided into traditional prospective (n = 61) and Doppler-guided prospective (n = 58) ECG gating groups. The exposure window of traditional prospective ECG gating was set at 30%–80% of the cardiac cycle. For the Doppler group, the length of diastasis was analyzed by Doppler. For lengths greater than 90 ms, the pulsing window was preset during diastole (during 60%–80%); otherwise, the optimal pulsing intervals were moved from diastole to systole (during 30%–50%). Results The mean heart rates of the traditional ECG and the Doppler-guided group during CT scanning were 75.0±7.7 bpm (range, 66–96 bpm) and 76.5±5.4 bpm (range: 66–105 bpm), respectively. The results indicated that whereas the image quality showed no significant difference between the traditional and Doppler groups (P = 0.42), the radiation dose of the Doppler group was significantly lower than that of the traditional group (5.2±3.4mSv vs. 9.3±4.5mSv, P<0.001). The sensitivities of CTA applying traditional and Doppler-guided prospective ECG gating to diagnose stenosis on a segment level were 95.5% and 94.3%, respectively; specificities 98.0% and 97.1%, respectively; positive predictive values 90.7% and 88.2%, respectively; negative predictive values 99.0% and 98.7%, respectively. There was no statistical difference in concordance between the traditional and Doppler groups (P = 0.22). Conclusion Doppler-guided prospective ECG gating represents an improved method in patients with a high heart rate to reduce effective radiation doses, while maintaining high diagnostic accuracy. PMID:23696793

Medical Ultrasound Imaging.

ERIC Educational Resources Information Center

Hughes, Stephen

2001-01-01

Explains the basic principles of ultrasound using everyday physics. Topics include the generation of ultrasound, basic interactions with material, and the measurement of blood flow using the Doppler effect. (Author/MM)

Verification of Wind Measurement with Mobile Laser Doppler System

DOT National Transportation Integrated Search

1977-09-01

The Lockheed Mobile Atmospheric Unit is a laser Doppler velocimeter system designed for the remote measurement of the three components of atmospheric wind. The unit was tested at the National Oceanic and Atmospheric Administration Table Mountain Test...

77 FR 37470 - Technical Standard Order (TSO)-C65a, Airborne Doppler Radar Ground Speed and/or Drift Angle...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-21

... inputs to semiautomatic self-contained dead reckoning navigation systems which were not continuously... Doppler sensor equipment that provides inputs to dead reckoning navigation systems obsolete. On August 18...

OBSERVATIONAL EVIDENCE OF ELECTRON-DRIVEN EVAPORATION IN TWO SOLAR FLARES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, D.; Ning, Z. J.; Zhang, Q. M., E-mail: lidong@pmo.ac.cn

2015-11-01

We have explored the relationship between hard X-ray (HXR) emissions and Doppler velocities caused by the chromospheric evaporation in two X1.6 class solar flares on 2014 September 10 and October 22, respectively. Both events display double ribbons and the Interface Region Imaging Spectrograph slit is fixed on one of their ribbons from the flare onset. The explosive evaporations are detected in these two flares. The coronal line of Fe xxi 1354.09 Å shows blueshifts, but the chromospheric line of C i 1354.29 Å shows redshifts during the impulsive phase. The chromospheric evaporation tends to appear at the front of themore » flare ribbon. Both Fe xxi and C i display their Doppler velocities with an “increase-peak-decrease” pattern that is well related to the “rising-maximum-decay” phase of HXR emissions. Such anti-correlation between HXR emissions and Fe xxi Doppler shifts and correlation with C i Doppler shifts indicate the electron-driven evaporation in these two flares.« less

Millimeter-wave micro-Doppler measurements of small UAVs

NASA Astrophysics Data System (ADS)

Rahman, Samiur; Robertson, Duncan A.

2017-05-01

This paper discusses the micro-Doppler signatures of small UAVs obtained from a millimeter-wave radar system. At first, simulation results are shown to demonstrate the theoretical concept. It is illustrated that whilst the propeller rotation rate of the small UAVs is quite high, millimeter-wave radar systems are capable of capturing the full micro-Doppler spread. Measurements of small UAVs have been performed with both CW and FMCW radars operating at 94 GHz. The CW radar was used for obtaining micro-Doppler signatures of individual propellers. The field test data of a flying small UAV was collected with the FMCW radar and was processed to extract micro-Doppler signatures. The high fidelity results clearly reveal features such as blade flashes and propeller rotation modulation lines which can be used to classify targets. This work confirms that millimeter-wave radar is suitable for the detection and classification of small UAVs at usefully long ranges.

Multimodal integration of micro-Doppler sonar and auditory signals for behavior classification with convolutional networks.

PubMed

Dura-Bernal, Salvador; Garreau, Guillaume; Georgiou, Julius; Andreou, Andreas G; Denham, Susan L; Wennekers, Thomas

2013-10-01

The ability to recognize the behavior of individuals is of great interest in the general field of safety (e.g. building security, crowd control, transport analysis, independent living for the elderly). Here we report a new real-time acoustic system for human action and behavior recognition that integrates passive audio and active micro-Doppler sonar signatures over multiple time scales. The system architecture is based on a six-layer convolutional neural network, trained and evaluated using a dataset of 10 subjects performing seven different behaviors. Probabilistic combination of system output through time for each modality separately yields 94% (passive audio) and 91% (micro-Doppler sonar) correct behavior classification; probabilistic multimodal integration increases classification performance to 98%. This study supports the efficacy of micro-Doppler sonar systems in characterizing human actions, which can then be efficiently classified using ConvNets. It also demonstrates that the integration of multiple sources of acoustic information can significantly improve the system's performance.