Science.gov

Sample records for dos activimetros utilizados

  1. DOS.

    ERIC Educational Resources Information Center

    Traven, Bill

    1988-01-01

    Discusses using the DOS PATH command (for MS-DOS) to enable the microcomputer user to move from directory to directory on a hard drive. Lists the commands to be programed, gives examples, and explains the use of each. (MVL)

  2. DOS basics

    SciTech Connect

    O`Connor, P.

    1994-09-01

    DOS is an acronym for Disk Operating System. It is actually a set of programs that allows you to control your personal computer. DOS offers the capabilities to create and manage files; organize and maintain information placed on disks; use application programs such as WordPerfect, Lotus 123, Excel, Windows, etc. In addition, DOS provides the basic utilities needed to copy files from one area to another, delete files and list files. The latest version of DOS also offers more advanced features that include hard disk compression and memory management. Basic DOS commands are discussed.

  3. A DOS Primer for Librarians.

    ERIC Educational Resources Information Center

    Beecher, Henry

    1989-01-01

    Presents a basic orientation to the functions and capabilities of disk operating systems (DOS), aimed at the nontechnically oriented user of IBM personal computers and compatible microcomputers. Areas discussed include booting up, the use of floppy and hard disks, file storage and manipulation, and directories. Further readings are provided. (CLB)

  4. A DOS Primer for Librarians: Part II.

    ERIC Educational Resources Information Center

    Beecher, Henry

    1990-01-01

    Provides an introduction to DOS commands and strategies for the effective organization and use of hard disks. Functions discussed include the creation of directories and subdirectories, enhanced copying, the assignment of disk drives, and backing up the hard disk. (CLB)

  5. DOS Batch Files As Control Programs

    NASA Technical Reports Server (NTRS)

    Van Dyk, David A.

    1991-01-01

    Computer-programming technique circumvents maximum of 640K imposed on random-access memory (RAM) by DOS (Disk Operating System) software. Involves breaking application program into smaller programs. Each resulting subprogram, when compiled and linked, must be small enough to fit within 640K of RAM. Retrieved from storage on disk as needed. In terms of DOS software, each subprogram ".EXE" file executed in "stand-alone" manner.

  6. 27 CFR 9.175 - Dos Rios.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.175 Dos Rios. (a... is located in northern Mendocino County, California, at the confluence of the Eel River and the Middle Fork of the Eel River. The area's boundaries are defined as follows— (1) Beginning in...

  7. "DOS for Managers." Management Training Series.

    ERIC Educational Resources Information Center

    Marion County Schools, Fairmont, WV.

    A plan is provided for a lesson on disk operating systems (DOS) for managers. Twenty-five lesson objectives are listed, followed by suggestions for learning activities and special resources. In the presentation section, key points and content are provided for 25 instructional topics that correspond to the 25 lesson objectives. The topics are as…

  8. DOS: the discrete-ordinates system. [LMFBR

    SciTech Connect

    Rhoades, W. A.; Emmett, M. B.

    1982-09-01

    The Discrete Ordinates System determines the flux of neutrons or photons due either to fixed sources specified by the user or to sources generated by particle interaction with the problem materials. It also determines numerous secondary results which depend upon flux. Criticality searches can be performed. Numerous input, output, and file manipulation facilities are provided. The DOS driver program reads the problem specification from an input file and calls various program modules into execution as specified by the input file.

  9. DIGLIB. PC-DOS Graphics Subroutine Library

    SciTech Connect

    Brand, H.R.

    1989-02-01

    DIGLIB is a collection of general graphics subroutines. It was designed to be small, reasonably fast, device-independent, and compatible with DEC-supplied operating systems for VAXes, PDP-11s, and LSI-11s, and the DOS operating system for IBM PCs and IBM-compatible machines. DIGLIB/VMS runs on the VAX and MicroVAX series of computers under VMS. The software is readily usable by casual programmers for two-dimensional plotting.

  10. From DOS to UNIX: An independent's experience

    SciTech Connect

    Hepguler, G.; Meehan, D.N.

    1993-06-01

    Union Pacific Resources Co. (UPRC) is a large independent operator with about 100 petroleum engineers. UPRC has a reasonably sophisticated PC network with many hundreds of PC's connected by several local area network (LAN) servers. Essentially all engineers have a 386-based PC on their desks with access to a host of software packages, peripheral devices, and mainframe computers, Many engineers have acquired 486-based PC's. UPRC's solution has involved migrating from a DOS-based platform on individual users' desks to UNIX workstations. Dozens of UNIX workstations are networked; some are on the desk', while others are located in central locations. Reservoir simulation, geostatistical modeling, image processing, and log analysis are now done exclusively on the UNIX workstations. Numerous DOS-based programs, however, have not yet been migrated into the UNIX environment. This paper describes the topography of both PC DOS and UNIX workstations networks in UPRC and examines the flow of information in each network configuration to identify differences. The successes and failures of various techniques for providing access to both platforms are presented.

  11. Fast interrupt platform for extended DOS

    NASA Technical Reports Server (NTRS)

    Duryea, T. W.

    1995-01-01

    Extended DOS offers the unique combination of a simple operating system which allows direct access to the interrupt tables, 32 bit protected mode access to 4096 MByte address space, and the use of industry standard C compilers. The drawback is that fast interrupt handling requires both 32 bit and 16 bit versions of each real-time process interrupt handler to avoid mode switches on the interrupts. A set of tools has been developed which automates the process of transforming the output of a standard 32 bit C compiler to 16 bit interrupt code which directly handles the real mode interrupts. The entire process compiles one set of source code via a make file, which boosts productivity by making the management of the compile-link cycle very simple. The software components are in the form of classes written mostly in C. A foreground process written as a conventional application which can use the standard C libraries can communicate with the background real-time classes via a message passing mechanism. The platform thus enables the integration of high performance real-time processing into a conventional application framework.

  12. Teaching Bibliometric Analysis and MS/DOS Commands.

    ERIC Educational Resources Information Center

    Dou, Henri; And Others

    1988-01-01

    Outlines the steps involved in bibliometric studies, and demonstrates the ability to execute simple studies on microcomputers by downloading files using only the capability of MS/DOS. Detailed illustrations of the MS/DOS commands used are provided. (eight references) (CLB)

  13. The Heme-Based Oxygen-Sensor Phosphodiesterase Ec DOS (DosP): Structure-Function Relationships

    PubMed Central

    Shimizu, Toru

    2013-01-01

    Escherichia coli Direct Oxygen Sensor (Ec DOS, also known as Ec DosP) is a heme-based O2-sensing phosphodiesterase from Escherichia coli that catalyzes the conversion of cyclic-di-GMP to linear di-GMP. Cyclic-di-GMP is an important second messenger in bacteria, highlighting the importance of understanding structure-function relationships of Ec DOS. Ec DOS is composed of an N-terminal heme-bound O2-sensing PAS domain and a C-terminal phosphodiesterase catalytic domain. Notably, its activity is markedly enhanced by O2 binding to the heme Fe(II) complex in the PAS sensor domain. X-ray crystal structures and spectroscopic and catalytic characterization of the wild-type and mutant proteins have provided important structural and functional clues to understanding the molecular mechanism of intramolecular catalytic regulation by O2 binding. This review summarizes the intriguing findings that have obtained for Ec DOS. PMID:25586128

  14. Izabel dos Santos and the training of the health workers.

    PubMed

    Paiva, Carlos Henrique Assunção

    2015-06-01

    This article discusses the career of Izabel dos Santos (1927-2010) as a means of examining the connections between health schools and agendas in contemporary Brazil. The article highlights dos Santos's training and her work in the Serviço Especial de Saúde Pública (SESP- Special Public Health Service), the Pan American Health Organization (PAHO) and in the formulation and implementation of national training programs for human resources within the area of health from the late 1970s onwards. The article highlights dos Santos's central role in the formulation and implementation of training policies for health workers, especially nursing technicians and assistants, and demonstrates how she occupies an important place in the history of Brazilian public health.

  15. Dos dosis de vacuna contra los VPH pueden proteger

    Cancer.gov

    Dos dosis de Cervarix, la vacuna contra virus del papiloma humano (VPH), fueron tan efectivas como la pauta normal actual de tres dosis después de cuatro años de seguimiento. El estudio de vacuna en Costa Rica, patrocinado por el NCI, fue diseñado para ev

  16. Special Section--Library Workstations: Mac and DOS.

    ERIC Educational Resources Information Center

    Valauskas, Ed; Flower, Eric

    1993-01-01

    Two articles discuss the library hardware marketplace. The first examines the Apple Macintosh in libraries from 1984 to the present, including linking libraries, computers, and endusers over large geographic distances. The second article discusses upgrading components of systems in the IBM compatible, MS-DOS, and Windows environments as costs…

  17. MS DOS Tool Software Including Public Domain, Grades K-6.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Computer Information Services.

    This curriculum guide is designed to assist teachers and supervisors in introducing lower elementary students to the MS DOS computer and the word processing program PC Write. Accompanying this guide are two program disks: PC Write, which is a public domain word processing program and Disk Care, which reinforces rules for caring for disks. The…

  18. Deceiving entropy-based DoS detection

    NASA Astrophysics Data System (ADS)

    Özçelik, Ä.°lker; Brooks, Richard R.

    2014-06-01

    Denial of Service (DoS) attacks disable network services for legitimate users. A McAfee report shows that eight out of ten Critical Infrastructure Providers (CIPs) surveyed had a significant Distributed DoS (DDoS) attack in 2010.1 Researchers proposed many approaches for detecting these attacks in the past decade. Anomaly based DoS detection is the most common. In this approach, the detector uses statistical features; such as the entropy of incoming packet header fields like source IP addresses or protocol type. It calculates the observed statistical feature and triggers an alarm if an extreme deviation occurs. However, intrusion detection systems (IDS) using entropy based detection can be fooled by spoofing. An attacker can sniff the network to collect header field data of network packets coming from distributed nodes on the Internet and fuses them to calculate the entropy of normal background traffic. Then s/he can spoof attack packets to keep the entropy value in the expected range during the attack. In this study, we present a proof of concept entropy spoofing attack that deceives entropy based detection approaches. Our preliminary results show that spoofing attacks cause significant detection performance degradation.

  19. Structures of Mycobacterium tuberculosis DosR and DosR-DNA Complex Involved in Gene Activation during Adaptation to Hypoxic Latency

    SciTech Connect

    Wisedchaisri, Goragot; Wu, Meiting; Rice, Adrian E; Roberts, David M; Sherman, David R; Hol, Wim G.J.

    2010-07-20

    On encountering low oxygen conditions, DosR activates the transcription of 47 genes, promoting long-term survival of Mycobacterium tuberculosis in a non-replicating state. Here, we report the crystal structures of the DosR C-terminal domain and its complex with a consensus DNA sequence of the hypoxia-induced gene promoter. The DosR C-terminal domain contains four {alpha}-helices and forms tetramers consisting of two dimers with non-intersecting dyads. In the DNA-bound structure, each DosR C-terminal domain in a dimer places its DNA-binding helix deep into the major groove, causing two bends in the DNA. DosR makes numerous protein-DNA base contacts using only three amino acid residues per subunit: Lys179, Lys182, and Asn183. The DosR tetramer is unique among response regulators with known structures.

  20. A natural product based DOS library of hybrid systems.

    PubMed

    Prabhu, Ganesh; Agarwal, Shalini; Sharma, Vijeta; Madurkar, Sanjay M; Munshi, Parthapratim; Singh, Shailja; Sen, Subhabrata

    2015-05-01

    Here we described a natural product inspired modular DOS strategy for the synthesis of a library of hybrid systems that are structurally and stereochemically disparate. The main scaffold is a pyrroloisoquinoline motif, that is synthesized from tandem Pictet-Spengler lactamization. The structural diversity is generated via "privileged scaffolds" that are attached at the appropriate site of the motif. Screening of the library compounds for their antiplasmodial activity against chloroquine sensitive 3D7 cells indicated few compounds with moderate activity (20-50 μM). A systematic comparison of structural intricacy between the library members and a natural product dataset obtained from ZINC(®) revealed comparable complexity. PMID:25794788

  1. Sedimentation survey of Lago Dos Bocas, Puerto Rico, June 1985

    USGS Publications Warehouse

    Quinones, Ferdinand; Melendez, Frank; Bonnet, Carlos

    1989-01-01

    A survey of the sedimentation of Dos Bocas reservoir, in central Puerto Rico, was conducted during July 1985. The survey showed that the capacity of the reservoir has declined from 30,420 acre-ft in 1942 to about 19,620 acre-ft. Sediment is accumulating in the reservoir at an average rate of about 251 acre-ft/yr, or about 0.83%/yr of the original capacity. The expected usable life of the reservoir on the basis of the long-term sedimentation rate is about 78 years. However, the sedimentation rate appears to have increased significantly since 1979. During the last six years, the average sedimentation rate has exceeded 600 acre-ft/yr. If this rate is maintained, the expected usable life of the reservoir would be about 32 years. (Author 's abstract)

  2. Document image archive transfer from DOS to UNIX

    NASA Technical Reports Server (NTRS)

    Hauser, Susan E.; Gill, Michael J.; Thoma, George R.

    1994-01-01

    An R&D division of the National Library of Medicine has developed a prototype system for automated document image delivery as an adjunct to the labor-intensive manual interlibrary loan service of the library. The document image archive is implemented by a PC controlled bank of optical disk drives which use 12 inch WORM platters containing bitmapped images of over 200,000 pages of medical journals. Following three years of routine operation which resulted in serving patrons with articles both by mail and fax, an effort is underway to relocate the storage environment from the DOS-based system to a UNIX-based jukebox whose magneto-optical erasable 5 1/4 inch platters hold the images. This paper describes the deficiencies of the current storage system, the design issues of modifying several modules in the system, the alternatives proposed and the tradeoffs involved.

  3. The Mycobacterium DosR regulon structure and diversity revealed by comparative genomic analysis.

    PubMed

    Chen, Tian; He, Liming; Deng, Wanyan; Xie, Jianping

    2013-01-01

    Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), which claims approximately two million people annually, remains a global health concern. The non-replicating or dormancy like state of this pathogen which is impervious to anti-tuberculosis drugs is widely recognized as the culprit for this scenario. The dormancy survival regulator (DosR) regulon, composed of 48 co-regulated genes, is held as essential for Mtb persistence. The DosR regulon is regulated by a two-component regulatory system consisting of two sensor kinases-DosS (Rv3132c) and DosT (Rv2027c), and a response regulator DosR (Rv3133c). The underlying regulatory mechanism of DosR regulon expression is very complex. Many factors are involved, particularly the oxygen tension. The DosR regulon enables the pathogen to persist during lengthy hypoxia. Comparative genomic analysis demonstrated that the DosR regulon is widely distributed among the mycobacterial genomes, ranging from the pathogenic strains to the environmental strains. In-depth studies on the DosR response should provide insights into its role in TB latency in vivo and shape new measures to combat this exceeding recalcitrant pathogen.

  4. Novas determinações dos parâmetros atmosféricos das estrelas anãs brancas DA

    NASA Astrophysics Data System (ADS)

    Giovannini, O.; Costa, A. F. M.; Kepler, S. O.

    2003-08-01

    Nós temos selecionado uma amostra de estrelas anãs brancas DA (atmosfera de hidrogênio) a partir dos índices de Strömgren cujos valores estão próximos a região de instabilidade das estrelas anãs brancas DA variáveis, as chamadas estrelas DAV ou ZZ Ceti. O objetivo é determinar os parâmetros fundamentais (temperatura efetiva, Teff, aceleração da gravidade, log g, e massa) destas estrelas para verificar quais os parâmetros estelares estão envolvidos com o mecanismo de pulsação das estrelas DAV. Nós obtemos, até agora, mais de 120 espectros óticos de estrelas DA. Entre as estrelas selecionadas há 20 estrelas variáveis (DAV). Assim, podemos verificar se existem ou não estrelas não variáveis dentro da faixa de instabilidade das estrelas ZZ Ceti. Neste trabalho nós apresentamos a determinação dos parâmetros atmosféricos (temperatura efetiva, Teff, e aceleração da gravidade, log g) das estrelas anãs brancas DA usando os novos modelos de atmosfera ML2/a = 0.6. Estes modelos têm sido utilizados recentemente por fornecerem uma excelente consistência interna na determinação das temperaturas nas regiões do ultra-violeta e ótico. Os parâmetros atmosféricos são determinados espectroscopicamente através da comparação do fluxo de energia das linhas de Balmer (Hb à H9) entre os espectros observados e sintéticos (gerados pelos modelos de atmosfera). As temperaturas obtidas com os novos modelos são, em geral, menores (~ 1000 K menos) que as temperaturas determinadas anteriormente, com modelos ML1. Os valores de log g não mudaram significativamente (menos de 10%). A faixa de instabilidade das DAVs está entre 11000 e 13000 K, consistente com dados de outros autores.

  5. 33 CFR 106.250 - Declaration of Security (DoS).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., ensure the Facility Security Officer (FSO) and Master, Vessel Security Officer (VSO), or their designated... FSO and Master, VSO, or their designated representatives, must sign the written DoS. (c) Neither...

  6. The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence

    PubMed Central

    Mehra, Smriti; Foreman, Taylor W.; Didier, Peter J.; Ahsan, Muhammad H.; Hudock, Teresa A.; Kissee, Ryan; Golden, Nadia A.; Gautam, Uma S.; Johnson, Ann-Marie; Alvarez, Xavier; Russell-Lodrigue, Kasi E.; Doyle, Lara A.; Roy, Chad J.; Niu, Tianhua; Blanchard, James L.; Khader, Shabaana A.; Lackner, Andrew A.; Sherman, David R.

    2015-01-01

    Rationale: Hypoxia promotes dormancy by causing physiologic changes to actively replicating Mycobacterium tuberculosis. DosR controls the response of M. tuberculosis to hypoxia. Objectives: To understand DosR's contribution in the persistence of M. tuberculosis, we compared the phenotype of various DosR regulon mutants and a complemented strain to M. tuberculosis in macaques, which faithfully model M. tuberculosis infection. Methods: We measured clinical and microbiologic correlates of infection with M. tuberculosis relative to mutant/complemented strains in the DosR regulon, studied lung pathology and hypoxia, and compared immune responses in lung using transcriptomics and flow cytometry. Measurements and Main Results: Despite being able to replicate initially, mutants in DosR regulon failed to persist or cause disease. On the contrary, M. tuberculosis and a complemented strain were able to establish infection and tuberculosis. The attenuation of pathogenesis in animals infected with the mutants coincided with the appearance of a Th1 response and organization of hypoxic lesions wherein M. tuberculosis expressed dosR. The lungs of animals infected with the mutants (but not the complemented strain) exhibited early transcriptional signatures of T-cell recruitment, activation, and proliferation associated with an increase of T cells expressing homing and proliferation markers. Conclusions: Delayed adaptive responses, a hallmark of M. tuberculosis infection, not only lead to persistence but also interfere with the development of effective antituberculosis vaccines. The DosR regulon therefore modulates both the magnitude and the timing of adaptive immune responses in response to hypoxia in vivo, resulting in persistent infection. Hence, DosR regulates key aspects of the M. tuberculosis life cycle and limits lung pathology. PMID:25730547

  7. Non-invasive tissue temperature measurements based on quantitative diffuse optical spectroscopy (DOS) of water

    PubMed Central

    Chung, SH; Cerussi, AE; Merritt, SI; Ruth, J; Tromberg, BJ

    2012-01-01

    We describe the development of a non-invasive method for quantitative tissue temperature measurements using Broadband diffuse optical spectroscopy (DOS). Our approach is based on well-characterized opposing shifts in near-infrared (NIR) water absorption spectra that appear with temperature and macromolecular binding state. Unlike conventional reflectance methods, DOS is used to generate scattering-corrected tissue water absorption spectra. This allows us to separate the macromolecular bound water contribution from the thermally induced spectral shift using the temperature isosbestic point at 996 nm. The method was validated in intralipid tissue phantoms by correlating DOS with thermistor measurements (R = 0.96) with a difference of 1.1 ± 0.91 °C over a range of 28–48 °C. Once validated, thermal and hemodynamic (i.e. oxy- and deoxy-hemoglobin concentration) changes were measured simultaneously and continuously in human subjects (forearm) during mild cold stress. DOS-measured arm temperatures were consistent with previously reported invasive deep tissue temperature studies. These results suggest that DOS can be used for non-invasive, co-registered measurements of absolute temperature and hemoglobin parameters in thick tissues, a potentially important approach for optimizing thermal diagnostics and therapeutics. PMID:20551502

  8. Documenting 35 Years of Land Cover Change: Lago Cachet Dos Drainage, Chile

    NASA Astrophysics Data System (ADS)

    Friesen, B.; Nimick, D.; McGrath, D.; Cole, C.

    2014-12-01

    The U.S. Geological Survey (USGS) Special Applications Science Center is monitoring temporal changes at the Colonia Glacier and Lago Cachet Dos, Northern Patagonia Icefield of southern Chile. This location is one of the newest international sites in the USGS Global Fiducial Program (GFP)—a program which provides systematic monitoring of dynamic and environmentally critical areas with high-resolution imagery (http://gfp.usgs.gov/). In 2008, Lago Cachet Dos began experiencing glacial lake outburst floods (GLOFs) during which the entire pool of water (about 200 million m3) rapidly drains from the lake and flows south-southeast through the Colonia Glacier. These catastrophic events cause massive erosion of lake-bed and valley-fill deposits, and consequent upstream expansion of Lago Cachet Dos towards Lago Cachet Uno. Panchromatic and multispectral images for 1979, 2007, and 2014 highlight the dramatic changes that have occurred at this site over a 35-year period. The lake was smallest in 1979, when the Colonia Glacier was at its maximum thickness and extent during the study period. Between 1979 and 2007, the glacier shrank causing an increase in the surface area of the lake. The size of the lake increased substantially, from 2.98 km2 in 1979 to 4.41 km2 in 2014, primarily due to erosion of valley-fill deposits at its northern edge by the 15 GLOFs that occurred between April 2008 and February 2014. Ongoing studies of the Colonia Glacier and Lago Cachet Dos are focused on providing real-time monitoring of Lago Cachet Dos lake levels, understanding the history of advances and retreats of the Colonia Glacier, and determining the physical mechanisms and hazards associated with the GLOFs that come from Lago Cachet Dos.

  9. Documenting 35 years of land cover change: Lago Cachet Dos drainage, Chile

    USGS Publications Warehouse

    Friesen, Beverly A.; Nimick, David A.; Mcgrath, Daniel; Cole, Christopher J.; Wilson, Earl M.; Noble, Suzanne M.; Fahey, Mark J.; Leidich, Jonathan; O'Kuinghttons Villena, Jorge I.

    2015-01-01

    The U.S. Geological Survey (USGS) Special Applications Science Center is monitoring temporal changes at the Colonia Glacier and Lago Cachet Dos, Northern Patagonia Icefield of southern Chile. This location is one of the newest international sites in the USGS Global Fiducial Program (GFP)—a program which provides systematic monitoring of dynamic and environmentally critical areas with high-resolution imagery (http://gfp.usgs.gov/). In 2008, Lago Cachet Dos began experiencing glacial lake outburst floods (GLOFs) during which the entire pool of water (about 200 million cubic meters) rapidly drains from the lake and flows south-southeast through the Colonia Glacier. These catastrophic events cause massive erosion of valley-fill deposits and consequent upstream expansion of Lago Cachet Dos towards Lago Cachet Uno.  Panchromatic and multispectral images for 1979, 2007, and 2014 highlight the dramatic changes that have occurred at this site over a 35-year period. The lake was smallest in 1979, when the Colonia Glacier was at its maximum extent during the study period. Between 1979 and 2007, the glacier shrank causing an increase in the surface area of the lake. The size of the lake increased substantially, from 2.98 square kilometers (km2) in 1979 to 4.41 km2 in 2014, primarily due to erosion of valley-fill deposits upstream of its northern edge by the 15 GLOFs that occurred between April 2008 and February 2014. Ongoing studies of the Colonia Glacier and Lago Cachet Dos are focused on providing real-time monitoring of Lago Cachet Dos lake levels, understanding the history of advances and retreats of the Colonia Glacier, and determining the physical mechanisms and hazards associated with the GLOFs that come from Lago Cachet Dos.

  10. Reagent based DOS: a "Click, Click, Cyclize" strategy to probe chemical space.

    PubMed

    Rolfe, Alan; Lushington, Gerald H; Hanson, Paul R

    2010-05-01

    The synthesis of small organic molecules as probes for discovering new therapeutic agents has been an important aspect of chemical-biology. Herein we report a reagent-based, diversity-oriented synthetic (DOS) strategy to probe chemical and biological space via a "Click, Click, Cyclize" protocol. In this DOS approach, three sulfonamide linchpins underwent cyclization protocols with a variety of reagents to yield a collection of structurally diverse S-heterocycles. In silico analysis is utilized to evaluate the diversity of the compound collection against chemical space (PC analysis), shape space (PMI) and polar surface area (PSA) calculations.

  11. Entre Dos Mundos/Between Two Worlds: Youth Violence Prevention for Acculturating Latino Families

    ERIC Educational Resources Information Center

    Smokowski, Paul R.; Bacallao, Martica

    2009-01-01

    Objective: This study evaluated the efficacy of Entre Dos Mundos/Between Two Worlds (EDM) prevention for Latino adolescents. Method: In an experimental trial to compare implementation formats, 41 Latino families were randomly assigned to EDM action-oriented skills training groups, and 47 families were randomly assigned to unstructured EDM support…

  12. 33 CFR 106.250 - Declaration of Security (DoS).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Declaration of Security (DoS). 106.250 Section 106.250 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARINE SECURITY: OUTER CONTINENTAL SHELF (OCS) FACILITIES Outer Continental Shelf...

  13. 33 CFR 106.250 - Declaration of Security (DoS).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Declaration of Security (DoS). 106.250 Section 106.250 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARINE SECURITY: OUTER CONTINENTAL SHELF (OCS) FACILITIES Outer Continental Shelf...

  14. 33 CFR 106.250 - Declaration of Security (DoS).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Declaration of Security (DoS). 106.250 Section 106.250 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARINE SECURITY: OUTER CONTINENTAL SHELF (OCS) FACILITIES Outer Continental Shelf...

  15. 33 CFR 106.250 - Declaration of Security (DoS).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Declaration of Security (DoS). 106.250 Section 106.250 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARINE SECURITY: OUTER CONTINENTAL SHELF (OCS) FACILITIES Outer Continental Shelf...

  16. Low-Budget, Cost-Effective OCR: Optical Character Recognition for MS-DOS Micros.

    ERIC Educational Resources Information Center

    Perez, Ernest

    1990-01-01

    Discusses optical character recognition (OCR) for use with MS-DOS microcomputers. Cost effectiveness is considered, three types of software approaches to character recognition are explained, hardware and operation requirements are described, possible library applications are discussed, future OCR developments are suggested, and a list of OCR…

  17. Function, regulation and pathological roles of the Gab/DOS docking proteins

    PubMed Central

    2009-01-01

    Since their discovery a little more than a decade ago, the docking proteins of the Gab/DOS family have emerged as important signalling elements in metazoans. Gab/DOS proteins integrate and amplify signals from a wide variety of sources including growth factor, cytokine and antigen receptors as well as cell adhesion molecules. They also contribute to signal diversification by channelling the information from activated receptors into signalling pathways with distinct biological functions. Recent approaches in protein biochemistry and systems biology have revealed that Gab proteins are subject to complex regulation by feed-forward and feedback phosphorylation events as well as protein-protein interactions. Thus, Gab/DOS docking proteins are at the centre of entire signalling subsystems and fulfil an important if not essential role in many physiological processes. Furthermore, aberrant signalling by Gab proteins has been increasingly linked to human diseases from various forms of neoplasia to Alzheimer's disease. In this review, we provide a detailed overview of the structure, effector functions, regulation and evolution of the Gab/DOS family. We also summarize recent findings implicating Gab proteins, in particular the Gab2 isoform, in leukaemia, solid tumours and other human diseases. PMID:19737390

  18. MIIS to MS-DOS: Microcomputer Options for Online Catalog Support.

    ERIC Educational Resources Information Center

    Grotophorst, Clyde W.

    1986-01-01

    Describes use of personal computer at George Mason University to provide support to the online catalog. Merging of bibliographic information in MS-DOS format into database management system and experimentation with full-text retrieval packages (ZyIndex and SIRE) are discussed. Addresses and price information for hardware and software packages…

  19. Pygmy Rice Rat as Potential Host of Castelo dos Sonhos Hantavirus

    PubMed Central

    Travassos da Rosa, Elizabeth S.; Medeiros, Daniele B. A.; Nunes, Márcio R.T.; Simith, Darlene B.; Pereira, Armando de Souza; Elkhoury, Mauro R.; Lavocat, Marília; Marques, Aparecido A.R.; Via, Alba Valéria; D’Andrea, Paulo; Bonvicino, Cibele R.; Lemos, Elba Regina S.

    2011-01-01

    To study the dynamics of wild rodent populations and identify potential hosts for hantavirus, we conducted an eco-epidemiologic study in Campo Novo do Parecis, Mato Grosso State, Brazil. We detected and genetically characterized Castelo dos Sonhos virus found in a species of pygmy rice rat (Oligoryzomys utiaritensis). PMID:21801642

  20. Stretching the Software Dollar: MS-DOS Shareware and Public Domain Software.

    ERIC Educational Resources Information Center

    Grosch, Audrey N.

    1989-01-01

    Discusses shareware and public domain software for MS-DOS systems that are available through bulletin board systems (BBS). Problems with computer viruses are discussed; shareware available for communications, database and file management, spreadsheets, word processing, and menuing software is described; and source information for software is…

  1. MS DOS Tool Software Including Public Domain, Grades 6-12.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY.

    This curriculum guide is designed to assist teachers and supervisors in introducing middle and high school students to the MS DOS computer and its functional application software in word processing, database management, and spreadsheet analysis. The guide begins by introducing students to computers: when and how they are used, hardware and…

  2. Sedimentation survey of Lago Dos Bocas, Utuado, Puerto Rico, January 2010

    USGS Publications Warehouse

    Soler-López, Luis R.

    2014-01-01

    Lago Dos Bocas reservoir was completed in 1942 to provide water for hydroelectric power generation along the northern coast of Puerto Rico. The reservoir had an original storage capacity of 37.50 million cubic meters (Mm3). The dam is located about 9 kilometers (km) northeast of the town of Utuado, immediately downstream of the original confluence of the Río Grande de Arecibo and the Río Caonillas (fig. 1). The Puerto Rico Electric Power Authority (PREPA) owns and operates the Lago Dos Bocas reservoir, and since 1996, the reservoir has become an essential part of the Puerto Rico Aqueduct and Sewer Authority (PRASA) North Coast Superaqueduct Project. The Superaqueduct is supplied by controlled releases for hydroelectric power generation that replenish the public-supply raw-water intake pool located about 10 km downstream from the Lago Dos Bocas Dam (fig. 1). As of 2005, the Superaqueduct supplies about 4.03 cubic meters per second (m3/s) (348,192 cubic meters per day [m3/d]) of potable water to communities along the northern coast, from Arecibo to the San Juan metropolitan area. Because of the importance of the reservoir to the North Coast Superaqueduct, the U.S. Geological Survey (USGS), in cooperation with PRASA, conducted a sedimentation survey of Lago Dos Bocas in January 2009. The results of this survey were used to estimate the useful life and the firm yield of the reservoir, and evaluate the need to dredge the reservoir.

  3. Sedimentation History of Lago Dos Bocas, Puerto Rico, 1942-2005

    USGS Publications Warehouse

    Soler-López, Luis R.

    2007-01-01

    The Lago Dos Bocas Dam, located in the municipality of Utuado in north central Puerto Rico, was constructed in 1942 for hydroelectric power generation. The reservoir had an original storage capacity of 37.50 million cubic meters and a drainage area of 440 square kilometers. In 1948, the construction of the Lago Caonillas Dam on the Rio Caonillas branch of Lago Dos Bocas reduced the natural sediment-contributing drainage area to 310 square kilometers; therefore, the Lago Caonillas Dam is considered an effective sediment trap. Sedimentation in Lago Dos Bocas reservoir has reduced the storage capacity from 37.50 million cubic meters in 1942 to 17.26 million cubic meters in 2005, which represents a storage loss of about 54 percent. The long-term annual water-storage capacity loss rate remained nearly constant at about 320,000 cubic meters per year to about 1997. The inter-survey sedimentation rate between 1997 and 1999, however, is higher than the long-term rate at about 1.09 million cubic meters per year. Between 1999 and 2005 the rate is lower than the long-term rate at about 0.13 million cubic meters per year. The Lago Dos Bocas effective sediment-contributing drainage area had an average sediment yield of about 1,400 cubic meters per square kilometer per year between 1942 and 1997. This rate increased substantially by 1999 to about 4,600 cubic meters per square kilometer per year, probably resulting from the historical magnitude floods caused by Hurricane Georges in 1998. Recent data indicate that the Lago Dos Bocas drainage area sediment yield decreased substantially to about 570 cubic meters per square kilometer per year, which is much lower than the 1942-1997 area normalized sedimentation rate of 1,235 cubic meters per square kilometer per year. The impact of Hurricane Georges on the basin sediment yield could have been the cause of this change, since the magnitude of the floods could have nearly depleted the Lago Dos Bocas drainage area of easily erodible and

  4. First report of White spot syndrome virus in farmed and wild penaeid shrimp from lagoa dos patos estuary, southern brazil

    PubMed Central

    Cavalli, Lissandra Souto; Romano, Luis Alberto; Marins, Luis Fernando; Abreu, Paulo César

    2011-01-01

    In this study, we detected White spot syndrome virus (WSSV) in wild Farfantepenaeus paulensis collected in the Lagoa dos Patos estuary and cultivated Litopenaeus vannamei. This is the first report of WSSV in F. paulensis from Lagoa dos Patos and farmed L. vannamei shrimps in Rio Grande do Sul. PMID:24031739

  5. First report of White spot syndrome virus in farmed and wild penaeid shrimp from lagoa dos patos estuary, southern brazil.

    PubMed

    Cavalli, Lissandra Souto; Romano, Luis Alberto; Marins, Luis Fernando; Abreu, Paulo César

    2011-07-01

    In this study, we detected White spot syndrome virus (WSSV) in wild Farfantepenaeus paulensis collected in the Lagoa dos Patos estuary and cultivated Litopenaeus vannamei. This is the first report of WSSV in F. paulensis from Lagoa dos Patos and farmed L. vannamei shrimps in Rio Grande do Sul.

  6. Observational Assessment of Preschool Disruptive Behavior, Part II: Validity of the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS)

    ERIC Educational Resources Information Center

    Wakschlag, Lauren S.; Briggs-Gowan, Margaret J.; Hill, Carri; Danis, Barbara; Leventhal, Bennett L.; Keenan, Kate; Egger, Helen L.; Cicchetti, Domenic; Burns, James; Carter, Alice S.

    2008-01-01

    A study is conducted to determine whether the multidomain, multicontext Disruptive Behavior Diagnostic Observation Schedule (DB-DOS) is a valid observational method for assessing disruptive behavior of preschool children. It is concluded that the DB-DOS is a valid method for a direct observational assessment of clinically significant disruptive…

  7. ACONF DOS

    2009-03-25

    ACONF is a system which has been developed by Sandia National Laboratories. ACONF is a system for optimizing the interaction between generator, photovoltaic system, batteries, and load in independent non-grid-tied electrical systems. It is primarily used in rural locations where running utility lines proves costly if it is possible at all. It is controlled by an Ampro PC-104 Coremodule 400 controller system. The code for this system is written in the BASIC programming language. Themore » routine contained in this document was written originally by Phil Symons. ACONF is intended to increase the efficiency of freestanding electrical systems to increase battery life and more efficiently use generator fuel.« less

  8. Identificabilidade e estabilidade dos parâmetros no método Grade of Membership (GoM): considerações metodológicas e práticas

    PubMed Central

    Guedes, Gilvan Ramalho; Caetano, André Junqueira; Machado, Carla Jorge; Brondízio, Eduardo Sonewend

    2011-01-01

    O método Grade of Membership (GoM) tem sido cada vez mais utilizado por demógrafos brasileiros e tem a vantagem de possuir um parâmetro que mensura a heterogeneidade individual, com base nas correlações não-observáveis entre as categorias de resposta das variáveis de interesse, gerando um medida do grau de pertencimento de cada indivíduo a perfis extremos. Alguns autores, contudo, chamam atenção para questões importantes na calibragem dos modelos finais que utilizam o programa GoM versão 3.4, como o problema de identificabilidade – soluções múltiplas para parâmetros estimados. Neste artigo, é sugerido um procedimento capaz de identificar um modelo final com solução única que descreva os tipos puros mais fidedignos à base de dados, em uma tentativa de otimização. Para ilustrar esse processo, utilizou-se uma base de dados correspondente a um levantamento econômico e sociodemográfico de uma população de pequenos agricultores residentes ao longo da Rodovia Transamazônica, no Estado do Pará. Também identificou-se a existência de instabilidade nos parâmetros estimados pelo programa GoM 3.4, sendo proposto um método de estabilização de seus valores. Com esses procedimentos combinados, os usuários do programa GoM 3.4 poderão descrever sua base de dados de forma mais adequada e responder às críticas sobre questões de identificabilidade e estabilidade dos modelos resultantes. Essas soluções empíricas são relevantes por afetarem cálculos de prevalência e de incidência de eventos de interesse, além de trazerem consequências importantes sobre o ponto e o momento corretos para intervenções de políticas públicas ou de planejamento prospectivo em análises de projeção. PMID:21709732

  9. Using satellite images to monitor glacial-lake outburst floods: Lago Cachet Dos drainage, Chile

    USGS Publications Warehouse

    Friesen, Beverly A.; Cole, Christopher J.; Nimick, David A.; Wilson, Earl M.; Fahey, Mark J.; McGrath, Daniel J.; Leidich, Jonathan

    2015-01-01

    During 2008–2013, 14 GLOFs were released from Lago Cachet Dos and created environmental and safety concerns for downstream residents and to infrastructure. If GLOFs and the consequent headward erosion continue, the moraine that creates Lago Cachet Uno could be destabilized and breached, and the two lakes could merge. If the two lakes become connected, the volume of future GLOFs likely would be greater and thus cause longer and (or) more extensive flooding downstream. Additional GLOFs from Lago Cachet Dos are expected in the future, and continued environmental monitoring could provide an early warning system as well as scientific information that could increase our understanding of GLOFs and their consequences. GLOFs occur in glaciated areas around the world and remote sensing technologies can allow researchers to better understand—and potentially predict—future GLOF events.

  10. Protecting Web Services against DoS Attacks: A Case-Based Reasoning Approach

    NASA Astrophysics Data System (ADS)

    Pinzón, Cristian; de Paz, Juan F.; Zato, Carolina; Pérez, Javier

    The real-time detection is a key factor to detect and block DoS attacks within Web services. DoS attacks can be generated for different techniques that take advantage of points vulnerable within Web services. This paper describes a novel proposal based on a real time agent to classify user requests and detect and block malicious SOAP messages. The classification mechanism is based on a Case-Base Reasoning (CBR) model, where the different CBR phases are time bounded. Within the reuse phase of the CBR cycle is incorporated a mixture of experts to choose the most suitable technique of classification depending on the feature of the attack and the available time to solve the classification. A prototype of the architecture was developed and the results obtained are presented in this study.

  11. Perspectivas Futuras para o Observatório do Pico dos Dias

    NASA Astrophysics Data System (ADS)

    Bruch, Albert

    2004-02-01

    Com o Observatório Gemini plenamente operacional e o telescópio SOAR iniciando suas operações em breve, a astronomia observacional brasileira encontra-se no auge de uma transformação profunda que terá um impacto grave no Observatório do Pico dos Dias - OPD. Refletimos aqui sobre a natureza desse impacto e estratégias para manter a competitividade do OPD. Não queremos apresentar receitas prontas, mas idéias que poderão servir como base de discussão sobre o uso inteligente dos telescópios do OPD como parte do conjunto de instrumentos disponíveis à comunidade astronômica brasileira.

  12. An alternate hypothesis for the origin of Angra dos Reis - Porphyry, not cumulate

    NASA Technical Reports Server (NTRS)

    Treiman, A. H.

    1989-01-01

    The Angra dos Reis achondrite is a unique meteorite of potentially great importance for understanding the origins of the solar system and of the terrestrial planets. It is proposed that the meteorite, which consists of megacrysts of Al-Ti augite (fassaite) in skeletal or cellular shapes, olivine, and possibly whitlockite in a fine-grained groundmass of the same materials plus spinel, is a porphyritic igneous rock modified by metamorphism. In this interpretation, the megacrysts represent cellular-textured phenocrysts, and the fine-grain groundmass represents crystallized or devitrified magma. Phase equilibria suggest that Angra dos Reis-like compositions could grow phenocrysts of fassaite pyroxene, olivine, and whitlockite. These same compositions could crystallize, without crystal sorting or accumulation, to an almost monomineralic fassaite pyroxenite.

  13. Adaptive Suspicious Prevention for Defending DoS Attacks in SDN-Based Convergent Networks

    PubMed Central

    Dao, Nhu-Ngoc; Kim, Joongheon; Park, Minho; Cho, Sungrae

    2016-01-01

    The convergent communication network will play an important role as a single platform to unify heterogeneous networks and integrate emerging technologies and existing legacy networks. Although there have been proposed many feasible solutions, they could not become convergent frameworks since they mainly focused on converting functions between various protocols and interfaces in edge networks, and handling functions for multiple services in core networks, e.g., the Multi-protocol Label Switching (MPLS) technique. Software-defined networking (SDN), on the other hand, is expected to be the ideal future for the convergent network since it can provide a controllable, dynamic, and cost-effective network. However, SDN has an original structural vulnerability behind a lot of advantages, which is the centralized control plane. As the brains of the network, a controller manages the whole network, which is attractive to attackers. In this context, we proposes a novel solution called adaptive suspicious prevention (ASP) mechanism to protect the controller from the Denial of Service (DoS) attacks that could incapacitate an SDN. The ASP is integrated with OpenFlow protocol to detect and prevent DoS attacks effectively. Our comprehensive experimental results show that the ASP enhances the resilience of an SDN network against DoS attacks by up to 38%. PMID:27494411

  14. FlexyDos3D: a deformable anthropomorphic 3D radiation dosimeter: radiation properties

    NASA Astrophysics Data System (ADS)

    De Deene, Y.; Skyt, P. S.; Hil, R.; Booth, J. T.

    2015-02-01

    Three dimensional radiation dosimetry has received growing interest with the implementation of highly conformal radiotherapy treatments. The radiotherapy community faces new challenges with the commissioning of image guided and image gated radiotherapy treatments (IGRT) and deformable image registration software. A new three dimensional anthropomorphically shaped flexible dosimeter, further called ‘FlexyDos3D’, has been constructed and a new fast optical scanning method has been implemented that enables scanning of irregular shaped dosimeters. The FlexyDos3D phantom can be actuated and deformed during the actual treatment. FlexyDos3D offers the additional advantage that it is easy to fabricate, is non-toxic and can be molded in an arbitrary shape with high geometrical precision. The dosimeter formulation has been optimized in terms of dose sensitivity. The influence of the casting material and oxygen concentration has also been investigated. The radiophysical properties of this new dosimeter are discussed including stability, spatial integrity, temperature dependence of the dosimeter during radiation, readout and storage, dose rate dependence and tissue equivalence. The first authors Y De Deene and P S Skyt made an equivalent contribution to the experimental work presented in this paper.

  15. Adaptive Suspicious Prevention for Defending DoS Attacks in SDN-Based Convergent Networks.

    PubMed

    Dao, Nhu-Ngoc; Kim, Joongheon; Park, Minho; Cho, Sungrae

    2016-01-01

    The convergent communication network will play an important role as a single platform to unify heterogeneous networks and integrate emerging technologies and existing legacy networks. Although there have been proposed many feasible solutions, they could not become convergent frameworks since they mainly focused on converting functions between various protocols and interfaces in edge networks, and handling functions for multiple services in core networks, e.g., the Multi-protocol Label Switching (MPLS) technique. Software-defined networking (SDN), on the other hand, is expected to be the ideal future for the convergent network since it can provide a controllable, dynamic, and cost-effective network. However, SDN has an original structural vulnerability behind a lot of advantages, which is the centralized control plane. As the brains of the network, a controller manages the whole network, which is attractive to attackers. In this context, we proposes a novel solution called adaptive suspicious prevention (ASP) mechanism to protect the controller from the Denial of Service (DoS) attacks that could incapacitate an SDN. The ASP is integrated with OpenFlow protocol to detect and prevent DoS attacks effectively. Our comprehensive experimental results show that the ASP enhances the resilience of an SDN network against DoS attacks by up to 38%. PMID:27494411

  16. Adaptive Suspicious Prevention for Defending DoS Attacks in SDN-Based Convergent Networks.

    PubMed

    Dao, Nhu-Ngoc; Kim, Joongheon; Park, Minho; Cho, Sungrae

    2016-01-01

    The convergent communication network will play an important role as a single platform to unify heterogeneous networks and integrate emerging technologies and existing legacy networks. Although there have been proposed many feasible solutions, they could not become convergent frameworks since they mainly focused on converting functions between various protocols and interfaces in edge networks, and handling functions for multiple services in core networks, e.g., the Multi-protocol Label Switching (MPLS) technique. Software-defined networking (SDN), on the other hand, is expected to be the ideal future for the convergent network since it can provide a controllable, dynamic, and cost-effective network. However, SDN has an original structural vulnerability behind a lot of advantages, which is the centralized control plane. As the brains of the network, a controller manages the whole network, which is attractive to attackers. In this context, we proposes a novel solution called adaptive suspicious prevention (ASP) mechanism to protect the controller from the Denial of Service (DoS) attacks that could incapacitate an SDN. The ASP is integrated with OpenFlow protocol to detect and prevent DoS attacks effectively. Our comprehensive experimental results show that the ASP enhances the resilience of an SDN network against DoS attacks by up to 38%.

  17. Using 4DOS Batch Files To Create an Infrastructure That Makes It Easy for Students To Create and Maintain HTML Web Pages.

    ERIC Educational Resources Information Center

    Snyder, Robin M.

    This paper describes the use of simple 4DOS batch files to automate the creation and maintenance of an infrastructure to assist students in creating and maintaining HTML World Wide Web pages. Background is provided on Web pages, DOS, 4DOS, and batch files. The assumptions made in creating the infrastructure are summarized, and program statements…

  18. T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia.

    PubMed

    Riaño, Felipe; Arroyo, Leonar; París, Sara; Rojas, Mauricio; Friggen, Annemieke H; van Meijgaarden, Krista E; Franken, Kees L M C; Ottenhoff, Tom H M; García, Luis F; Barrera, Luis F

    2012-03-01

    Mycobacterium tuberculosis DosR regulon-encoded proteins elicit strong immune T-cell responses in individuals with latent tuberculosis (LTBI). Also, resuscitation (Rpf) proteins can induce such responses. However, variations in the immunogenicity of the DosR and Rpf proteins have been observed in European and African populations, and no data are published from other geographic areas. In Colombian LTBI and patients with recently diagnosed PTB, we therefore studied the immune response to DosR, Rpf, stress, and nominal antigens from Mtb, in 7-day stimulated cultures. Three DosR (Rv1737c, Rv2029c, Rv2628c) and 2 Rpf (Rv0867 and Rv2389c) antigens were recognized most prominently on the basis of the net IFNγ production (DosR) or the percentage of responding individuals (Rpf). Results show that the selected DosR antigens induced a higher proportion of CD4-T cells producing IFNγ from LTBI, compared to pulmonary TB patients (PTB), while there were no differences in the proportion of CD8-T cells. An increased frequency of CD4, but not CD8 T-cells with a CD45RO(+)CD27(+) phenotype was observed in LTBI in response to Rv2029c, Rv0867c, and Rv2389c, compared to PTB. The levels of cytokines and chemokines in the supernatants of stimulated cells, showed that the DosR and Rpf antigens induced higher levels of IFNγ in cultures from LTBI compared to PTB, although the induced pattern of cytokines and chemokines was also antigen dependent. In summary, our results are consistent with the significant immunogenicity of Mtb DosR and Rpf antigens in LTBI individuals, and confirm and extend previously reported data from other TB affected human populations.

  19. DoS detection in IEEE 802.11 with the presence of hidden nodes.

    PubMed

    Soryal, Joseph; Liu, Xijie; Saadawi, Tarek

    2014-07-01

    The paper presents a novel technique to detect Denial of Service (DoS) attacks applied by misbehaving nodes in wireless networks with the presence of hidden nodes employing the widely used IEEE 802.11 Distributed Coordination Function (DCF) protocols described in the IEEE standard [1]. Attacker nodes alter the IEEE 802.11 DCF firmware to illicitly capture the channel via elevating the probability of the average number of packets transmitted successfully using up the bandwidth share of the innocent nodes that follow the protocol standards. We obtained the theoretical network throughput by solving two-dimensional Markov Chain model as described by Bianchi [2], and Liu and Saadawi [3] to determine the channel capacity. We validated the results obtained via the theoretical computations with the results obtained by OPNET simulator [4] to define the baseline for the average attainable throughput in the channel under standard conditions where all nodes follow the standards. The main goal of the DoS attacker is to prevent the innocent nodes from accessing the channel and by capturing the channel's bandwidth. In addition, the attacker strives to appear as an innocent node that follows the standards. The protocol resides in every node to enable each node to police other nodes in its immediate wireless coverage area. All innocent nodes are able to detect and identify the DoS attacker in its wireless coverage area. We applied the protocol to two Physical Layer technologies: Direct Sequence Spread Spectrum (DSSS) and Frequency Hopping Spread Spectrum (FHSS) and the results are presented to validate the algorithm.

  20. DoS detection in IEEE 802.11 with the presence of hidden nodes.

    PubMed

    Soryal, Joseph; Liu, Xijie; Saadawi, Tarek

    2014-07-01

    The paper presents a novel technique to detect Denial of Service (DoS) attacks applied by misbehaving nodes in wireless networks with the presence of hidden nodes employing the widely used IEEE 802.11 Distributed Coordination Function (DCF) protocols described in the IEEE standard [1]. Attacker nodes alter the IEEE 802.11 DCF firmware to illicitly capture the channel via elevating the probability of the average number of packets transmitted successfully using up the bandwidth share of the innocent nodes that follow the protocol standards. We obtained the theoretical network throughput by solving two-dimensional Markov Chain model as described by Bianchi [2], and Liu and Saadawi [3] to determine the channel capacity. We validated the results obtained via the theoretical computations with the results obtained by OPNET simulator [4] to define the baseline for the average attainable throughput in the channel under standard conditions where all nodes follow the standards. The main goal of the DoS attacker is to prevent the innocent nodes from accessing the channel and by capturing the channel's bandwidth. In addition, the attacker strives to appear as an innocent node that follows the standards. The protocol resides in every node to enable each node to police other nodes in its immediate wireless coverage area. All innocent nodes are able to detect and identify the DoS attacker in its wireless coverage area. We applied the protocol to two Physical Layer technologies: Direct Sequence Spread Spectrum (DSSS) and Frequency Hopping Spread Spectrum (FHSS) and the results are presented to validate the algorithm. PMID:25685510

  1. DoS detection in IEEE 802.11 with the presence of hidden nodes

    PubMed Central

    Soryal, Joseph; Liu, Xijie; Saadawi, Tarek

    2013-01-01

    The paper presents a novel technique to detect Denial of Service (DoS) attacks applied by misbehaving nodes in wireless networks with the presence of hidden nodes employing the widely used IEEE 802.11 Distributed Coordination Function (DCF) protocols described in the IEEE standard [1]. Attacker nodes alter the IEEE 802.11 DCF firmware to illicitly capture the channel via elevating the probability of the average number of packets transmitted successfully using up the bandwidth share of the innocent nodes that follow the protocol standards. We obtained the theoretical network throughput by solving two-dimensional Markov Chain model as described by Bianchi [2], and Liu and Saadawi [3] to determine the channel capacity. We validated the results obtained via the theoretical computations with the results obtained by OPNET simulator [4] to define the baseline for the average attainable throughput in the channel under standard conditions where all nodes follow the standards. The main goal of the DoS attacker is to prevent the innocent nodes from accessing the channel and by capturing the channel’s bandwidth. In addition, the attacker strives to appear as an innocent node that follows the standards. The protocol resides in every node to enable each node to police other nodes in its immediate wireless coverage area. All innocent nodes are able to detect and identify the DoS attacker in its wireless coverage area. We applied the protocol to two Physical Layer technologies: Direct Sequence Spread Spectrum (DSSS) and Frequency Hopping Spread Spectrum (FHSS) and the results are presented to validate the algorithm. PMID:25685510

  2. Volcanic and structural controls of mineralization in the Dos Cabezas Mountains of southeastern Arizona

    SciTech Connect

    Drewes, H.; Klein, D.P.; Birmingham, S.D.

    1988-01-01

    A combination of geophysical, geochemical, and geological features suggests that a central part of the Dos Cabezas Mountains probably has considerable potential for blind deposits, chiefly base metals. The area exposes the root zone of a Paleocene( ) volcanic complex and its underlying granitic stocks, which were emplaced next to a major northwest-trending, much reactivated fault zone. The new data, combined with the knowledge of past mining activity in the area, lead them to propose several exploration targets that may lead to ore bodies in breccia pipes along the base of the volcanic pile and along a possible concealed fault or caldera margin.

  3. Use of Remote Sensing and Local Knowledge for Geoconservation of Regiao dos Lagos, Brazil

    NASA Astrophysics Data System (ADS)

    Avelar, S.; Vasconcelos, G.; Mansur, K. L.; Anjos, S. C.

    2013-12-01

    A series of lagoons can be found along the coastline of Rio de Janeiro, in the so-called Regiao dos Lagos. The lagoons differ in size, physicochemical, sedimentological and biological characteristics. Rare examples of litifying microbialites that produce stromatolites, the oldest fossils on Earth, can be found living in this lagoon system. The occurrence of stromatolites in the region is of great scientific interest because it enables the study of possible analogues of the earliest life on Earth. However, this region has been suffering from intense human activities and degradations. Geoconservation planning requires an assessment of the characteristics of the region and its potential threats. The primary goal of this study is to assess physical environmental changes and anthropogenic impacts over the last four decades in Regiao dos Lagos. Using a broad integrative assessment combining remote sensing, GIS, field studies and local knowledge of communities, land-cover and land-use classes were identified, as well as the main human activities impacting the environment. The seasonal and weekend tourism and urban sprawl in this coastal area of Rio de Janeiro triggers the occupation of new areas and the removal of natural vegetation, especially on lagoon margins. This disorderly occupation by an ever increasing population, with both legal and illegal constructions and the subsequent overload of the local infrastructure, e.g. increase of electrical energy consumption, volume of vehicles, pollution in air, water and soil and problems with water supply and wastewater treatment, are hastening the gradual degradation of the lake ecosystem. The main driving forces to environmental changes over the last four decades in Regiao dos Lagos were the change of dense vegetation, saline and bare soil classes into built-up areas, adding to the poor waste treatment and inadequate sewage disposal. This analysis provides a basis for a better control of anthropogenic impacts and

  4. Age and isotopic relationships among the angrites Lewis Cliff 86010 and Angra dos Reis

    SciTech Connect

    Lugmair, G.W. ); Galer, S.J.G. Max-Planck-Inst. fuer Chemie, Mainz )

    1992-04-01

    Results of a wide-ranging isotopic investigation of the unique Antarctican angrite LEW-86010 (LEW) are presented, together with a reassessment of the type angrite Angra dos Reis (ADOR). The principal objectives of this study are to obtain precise radiometric ages, initial Sr isotopic compositions, and to search for the erstwhile presence of the short-lived nuclei {sup 146}Sm and {sup 26}Al via their daughter products. The isotopic compositions of Sm, U, Ca, and Ti were also measured. This allows a detailed appraisal to be made of the relations between, and the genealogy of, these two angrites.

  5. Studies of Brazilian meteorites. III - Origin and history of the Angra dos Reis achondrite

    NASA Technical Reports Server (NTRS)

    Prinz, M.; Keil, K.; Hlava, P. F.; Berkley, J. L.; Gomes, C. B.; Curvello, W. S.

    1977-01-01

    The mineral composition of the Angra dos Reis meteorite, which fell in 1869, is described. This achondrite contains phases reported in a meteorite for the first time. Petrofabric analysis shows that fassaite has a preferred orientation and lineation, which is interpreted as being due to cumulus processes, possibly the effect of post-depositional magmatic current flow or laminar flow of a crystalline mush. The mineral chemistry indicates crystallization from a highly silica-undersaturated melt at low pressure. Several aspects of the mineral composition are discussed with reference to the implications of crystallization conditions.

  6. Electron spin resonance dating of megafauna from Lagoa dos Porcos, Piauí, Brazil.

    PubMed

    Kinoshita, Angela; Mayer, Elver; Ribau Mendes, Vinícius; Figueiredo, Ana Maria G; Baffa, Oswaldo

    2014-06-01

    Excavations performed at Lagoa dos Porcos site revealed a vast amount of extinct mammal fossil remains, becoming one of the richest palaeontological occurrences in the Serra da Capivara National Park region, a UNESCO World Heritage. Although anatomic and taxonomic aspects of extinct Quaternary mammals are relatively well known, chronologic information for deposits is rare. In this context, electron spin resonance (ESR) dating of megafauna samples provides important information for establishing a chronological background. This work presents the ESR dating of two teeth, one of Gomphotheriidae and other of Toxodontinae. Dose-response curves of each sample were constructed using spectra acquired with a JEOL FA-200 X-Band spectrometer resulting in equivalent dose (De) of 220 ± 40 Gy and 39 ± 2 Gy for Toxodontinae and Gomphotheriidae tooth, respectively. The conversion of De in age was made using ROSY ESR dating software resulting in 26 ± 4 and 22 ± 3 ka. These results place Lagoa dos Porcos fossil assemblage within the Late Pleistocene. These dates overlap with a period of abrupt increase in rainfall in northeast Brazil, and it is possible that this environmental change is related to the formation of this deposit.

  7. RighTime: A real time clock correcting program for MS-DOS-based computer systems

    NASA Technical Reports Server (NTRS)

    Becker, G. Thomas

    1993-01-01

    A computer program is described which effectively eliminates the misgivings of the DOS system clock in PC/AT-class computers. RighTime is a small, sophisticated memory-resident program that automatically corrects both the DOS system clock and the hardware 'CMOS' real time clock (RTC) in real time. RighTime learns what corrections are required without operator interaction beyond the occasional accurate time set. Both warm (power on) and cool (power off) errors are corrected, usually yielding better than one part per million accuracy in the typical desktop computer with no additional hardware, and RighTime increases the system clock resolution from approximately 0.0549 second to 0.01 second. Program tools are also available which allow visualization of RighTime's actions, verification of its performance, display of its history log, and which provide data for graphing of the system clock behavior. The program has found application in a wide variety of industries, including astronomy, satellite tracking, communications, broadcasting, transportation, public utilities, manufacturing, medicine, and the military.

  8. Quality control and assurance for validation of DOS/I measurements

    NASA Astrophysics Data System (ADS)

    Cerussi, Albert; Durkin, Amanda; Kwong, Richard; Quang, Timothy; Hill, Brian; Tromberg, Bruce J.; MacKinnon, Nick; Mantulin, William W.

    2010-02-01

    Ongoing multi-center clinical trials are crucial for Biophotonics to gain acceptance in medical imaging. In these trials, quality control (QC) and assurance (QA) are key to success and provide "data insurance". Quality control and assurance deal with standardization, validation, and compliance of procedures, materials and instrumentation. Specifically, QC/QA involves systematic assessment of testing materials, instrumentation performance, standard operating procedures, data logging, analysis, and reporting. QC and QA are important for FDA accreditation and acceptance by the clinical community. Our Biophotonics research in the Network for Translational Research in Optical Imaging (NTROI) program for breast cancer characterization focuses on QA/QC issues primarily related to the broadband Diffuse Optical Spectroscopy and Imaging (DOS/I) instrumentation, because this is an emerging technology with limited standardized QC/QA in place. In the multi-center trial environment, we implement QA/QC procedures: 1. Standardize and validate calibration standards and procedures. (DOS/I technology requires both frequency domain and spectral calibration procedures using tissue simulating phantoms and reflectance standards, respectively.) 2. Standardize and validate data acquisition, processing and visualization (optimize instrument software-EZDOS; centralize data processing) 3. Monitor, catalog and maintain instrument performance (document performance; modularize maintenance; integrate new technology) 4. Standardize and coordinate trial data entry (from individual sites) into centralized database 5. Monitor, audit and communicate all research procedures (database, teleconferences, training sessions) between participants ensuring "calibration". This manuscript describes our ongoing efforts, successes and challenges implementing these strategies.

  9. Dosimetry and Vibration measurements in BIOLAB and EMCS (Dos-ViBE)

    NASA Astrophysics Data System (ADS)

    Ideström, Johan Olof; Hendrik Anken, Ralf; Reitz, Guenther; Berger, Thomas; Hauslage, Jens; Schuber, Marianne; Fossum, Knut R.; Vanhavere, Filip

    Space irradiation and vibrations in even small dosages can impact biological experiments and have not yet been measured in the biological payloads of the Columbus module at the Interna-tional Space Station (ISS). Installing active dosimeters and accelerometers in the Experiment Containers (EC) of Biolab and the European Modular Cultivation System (EMCS), to sur-vey in-situ the radiation and vibrations in these facilities, should be performed to serve as a reference of the space conditions to future experiments. To monitor the radiation field, the space radiation should be measured with an active dosime-ter inside the Multi-User-Facilities, as close to the actual shielding conditions of the biological experiments as possible. To measure the full spectrum of vibration frequencies, several instru-ments with different measurement ranges and sensitivity should be combined. The radiation and vibrations should be measured simultaneously in Biolab and EMCS to compare their radiation shielding and sensitivities to vibrations from the ISS. The radiation could also be measured with passive dosimeters. On the one hand this would be a back-up to the active dosimeter and on the other hand it would provide additional data since the passive dosimeters can give additional information on the radiation LET spectrum. As a response to ESA's Announcement of Opportunity (ILSRA-2009), a joint experiment in Biolab and EMCS, entitled Dos-ViBE, was proposed by the co-authors. The objectives and experimental flow of Dos-ViBE are outlined in this presentation.

  10. Crystal Structures of the Response Regulator DosR From Mycobacterium Tuberculosis Suggest a Helix Rearrangement Mechanism for Phosphorylation Activation

    SciTech Connect

    Wisedchaisri, G.; Wu, M.; Sherman, D.R.; Hol, W.G.J.

    2009-05-26

    The response regulator DosR is essential for promoting long-term survival of Mycobacterium tuberculosis under low oxygen conditions in a dormant state and may be responsible for latent tuberculosis in one-third of the world's population. Here, we report crystal structures of full-length unphosphorylated DosR at 2.2 {angstrom} resolution and its C-terminal DNA-binding domain at 1.7 {angstrom} resolution. The full-length DosR structure reveals several features never seen before in other response regulators. The N-terminal domain of the full-length DosR structure has an unexpected ({beta}{alpha}){sub 4} topology instead of the canonical ({beta}{alpha}){sub 5} fold observed in other response regulators. The linker region adopts a unique conformation that contains two helices forming a four-helix bundle with two helices from another subunit, resulting in dimer formation. The C-terminal domain in the full-length DosR structure displays a novel location of helix {alpha}10, which allows Gln199 to interact with the catalytic Asp54 residue of the N-terminal domain. In contrast, the structure of the DosR C-terminal domain alone displays a remarkable unstructured conformation for helix {alpha}10 residues, different from the well-defined helical conformations in all other known structures, indicating considerable flexibility within the C-terminal domain. Our structures suggest a mode of DosR activation by phosphorylation via a helix rearrangement mechanism.

  11. Serine 83 in DosR, a response regulator from Mycobacterium tuberculosis, promotes its transition from an activated, phosphorylated state to an inactive, unphosphorylated state.

    PubMed

    Cho, Ha Yeon; Kang, Beom Sik

    2014-02-21

    A sensor kinase, DosS, and its corresponding response regulator, DosR, constitute a two component system for regulating gene expression under hypoxic conditions in Mycobacterium tuberculosis. Among response regulators in M. tuberculosis, NarL has high sequence similarity to DosR, and autophosphorylated DosS transfers its phosphate group not only to DosR but also to NarL. Phosphorylated DosR is more rapidly dephosphorylated than phosphorylated NarL. DosR and NarL differ with respect to the amino acids at positions T+1 and T+2 around the phosphorylation sites in the N-terminal phosphoacceptor domain; NarL has S83 and Y84, whereas DosR has A90 and H91. A DosR S83A mutant shows prolonged phosphorylation. Structural comparison with a histidinol phosphate phosphatase suggests that the hydroxyl group of DosR S83 could play a role in activating the water molecule involved in the triggering of autodephosphorylation.

  12. A Direct Method to Extract Transient Sub-Gap Density of State (DOS) Based on Dual Gate Pulse Spectroscopy

    PubMed Central

    Dai, Mingzhi; Khan, Karim; Zhang, Shengnan; Jiang, Kemin; Zhang, Xingye; Wang, Weiliang; Liang, Lingyan; Cao, Hongtao; Wang, Pengjun; Wang, Peng; Miao, Lijing; Qin, Haiming; Jiang, Jun; Xue, Lixin; Chu, Junhao

    2016-01-01

    Sub-gap density of states (DOS) is a key parameter to impact the electrical characteristics of semiconductor materials-based transistors in integrated circuits. Previously, spectroscopy methodologies for DOS extractions include the static methods, temperature dependent spectroscopy and photonic spectroscopy. However, they might involve lots of assumptions, calculations, temperature or optical impacts into the intrinsic distribution of DOS along the bandgap of the materials. A direct and simpler method is developed to extract the DOS distribution from amorphous oxide-based thin-film transistors (TFTs) based on Dual gate pulse spectroscopy (GPS), introducing less extrinsic factors such as temperature and laborious numerical mathematical analysis than conventional methods. From this direct measurement, the sub-gap DOS distribution shows a peak value on the band-gap edge and in the order of 1017–1021/(cm3·eV), which is consistent with the previous results. The results could be described with the model involving both Gaussian and exponential components. This tool is useful as a diagnostics for the electrical properties of oxide materials and this study will benefit their modeling and improvement of the electrical properties and thus broaden their applications. PMID:27297030

  13. DOS-HEATING6: A general conduction code with nuclear heat generation derived from DOT-IV transport calculations

    SciTech Connect

    Williams, M.L.; Yuecel, A.; Nadkarny, S.

    1988-05-01

    The HEATING6 heat conduction code is modified to (a) read the multigroup particle fluxes from a two-dimensional DOT-IV neutron- photon transport calculation, (b) interpolate the fluxes from the DOT-IV variable (optional) mesh to the HEATING6 control volume mesh, and (c) fold the interpolated fluxes with kerma factors to obtain a nuclear heating source for the heat conduction equation. The modified HEATING6 is placed as a module in the ORNL discrete ordinates system (DOS), and has been renamed DOS-HEATING6. DOS-HEATING6 provides the capability for determining temperature distributions due to nuclear heating in complex, multi-dimensional systems. All of the original capabilities of HEATING6 are retained for the nuclear heating calculation; e.g., generalized boundary conditions (convective, radiative, finned, fixed temperature or heat flux), temperature and space dependent thermal properties, steady-state or transient analysis, general geometry description, etc. The numerical techniques used in the code are reviewed and the user input instructions and JCL to perform DOS-HEATING6 calculations are presented. Finally a sample problem involving coupled DOT-IV and DOS-HEATING6 calculations of a complex space-reactor configurations described, and the input and output of the calculations are listed. 10 refs., 11 figs., 6 tabs.

  14. A Direct Method to Extract Transient Sub-Gap Density of State (DOS) Based on Dual Gate Pulse Spectroscopy

    NASA Astrophysics Data System (ADS)

    Dai, Mingzhi; Khan, Karim; Zhang, Shengnan; Jiang, Kemin; Zhang, Xingye; Wang, Weiliang; Liang, Lingyan; Cao, Hongtao; Wang, Pengjun; Wang, Peng; Miao, Lijing; Qin, Haiming; Jiang, Jun; Xue, Lixin; Chu, Junhao

    2016-06-01

    Sub-gap density of states (DOS) is a key parameter to impact the electrical characteristics of semiconductor materials-based transistors in integrated circuits. Previously, spectroscopy methodologies for DOS extractions include the static methods, temperature dependent spectroscopy and photonic spectroscopy. However, they might involve lots of assumptions, calculations, temperature or optical impacts into the intrinsic distribution of DOS along the bandgap of the materials. A direct and simpler method is developed to extract the DOS distribution from amorphous oxide-based thin-film transistors (TFTs) based on Dual gate pulse spectroscopy (GPS), introducing less extrinsic factors such as temperature and laborious numerical mathematical analysis than conventional methods. From this direct measurement, the sub-gap DOS distribution shows a peak value on the band-gap edge and in the order of 1017–1021/(cm3·eV), which is consistent with the previous results. The results could be described with the model involving both Gaussian and exponential components. This tool is useful as a diagnostics for the electrical properties of oxide materials and this study will benefit their modeling and improvement of the electrical properties and thus broaden their applications.

  15. An MS-DOS-based program for analyzing plutonium gamma-ray spectra

    SciTech Connect

    Ruhter, W.D.; Buckley, W.M.

    1989-09-07

    A plutonium gamma-ray analysis system that operates on MS-DOS-based computers has been developed for the International Atomic Energy Agency (IAEA) to perform in-field analysis of plutonium gamma-ray spectra for plutonium isotopics. The program titled IAEAPU consists of three separate applications: a data-transfer application for transferring spectral data from a CICERO multichannel analyzer to a binary data file, a data-analysis application to analyze plutonium gamma-ray spectra, for plutonium isotopic ratios and weight percents of total plutonium, and a data-quality assurance application to check spectral data for proper data-acquisition setup and performance. Volume 3 contains the software listings for these applications.

  16. On securing wireless sensor network--novel authentication scheme against DOS attacks.

    PubMed

    Raja, K Nirmal; Beno, M Marsaline

    2014-10-01

    Wireless sensor networks are generally deployed for collecting data from various environments. Several applications specific sensor network cryptography algorithms have been proposed in research. However WSN's has many constrictions, including low computation capability, less memory, limited energy resources, vulnerability to physical capture, which enforce unique security challenges needs to make a lot of improvements. This paper presents a novel security mechanism and algorithm for wireless sensor network security and also an application of this algorithm. The proposed scheme is given to strong authentication against Denial of Service Attacks (DOS). The scheme is simulated using network simulator2 (NS2). Then this scheme is analyzed based on the network packet delivery ratio and found that throughput has improved.

  17. The Secret List of Dos and Don'ts for Filmmaking

    NASA Astrophysics Data System (ADS)

    Kramer, N.

    2012-12-01

    Science is a massive black box to billions of people who walk the streets. However, the process of filmmaking can be equally as mystifying. As with the development of many scientific experiments, the process starts on a napkin at a restaurant…but then what? The road to scientific publication is propelled by a canonical list of several dos and don't that fit most situations. An equally useful list exists for up-and-coming producers. The list streamlines efforts, optimizes your use of the tools at your fingertips and enhances impact. Many fundamentals can be learned from books, but during this talk we will project and discuss several examples of best practices, from honing a story, to identifying audience appeal, filming, editing and the secrets of inexpensively acquiring expert help. Whether your goal is a two-minute webisode or a 90 minute documentary, these time-tested practices, with a little awareness, can give life to your films.;

  18. Estudio dinámico de un potencial perturbador dependiente de dos parámetros

    NASA Astrophysics Data System (ADS)

    Miloni, O.; Brunini, A.

    El objeto del presente trabajo consiste en el estudio dinámico de un sistema dinámico caracterizado por la función hamiltoniana correspondiente a un satélite planetario perturbado por la acción del Sol y del achatamiento del planeta madre. Cuando dicha Hamiltoniana se promedia respecto de los términos de corto período, esta queda con dos grados de libertad, y su estudio puede ser realizado con las herramientas clásicas de la dinámica no-lineal. Se tratará de determinar regiones regulares y caóticas de movimiento. En el caso de estas últimas, es de particular interés la determinación de su orígen.

  19. Sm-Nd-Pu timepieces in the Angra dos Reis meteorite

    NASA Technical Reports Server (NTRS)

    Lugmair, G. W.; Marti, K.

    1977-01-01

    Isotope ratios and age estimations are presented for the ultramafic pyroxenite Angra dos Reis meteorite. A pyroxene-phosphate internal isochron age of 4.55 plus or minus 0.04 eons was obtained, in agreement with reported Pb-Pb ages. It is suggested that Sm-146 decay led to an increase in the ratio of Nd-142 to Nd-144 in pyroxene, which is greater than the ratio of the Nd isotopes in phosphates. The effect of Pu-244 on the fission xenon components in pyroxene and phosphate is examined. The ratios of Pu-244 to Nd, U-238, and Th-232 are compared for pyroxene and phosphate separates. The exposure age of the meteorite, as obtained by the Kr-81 to Kr-83 method, was found to be 55.5 plus or minus 1.2 million years.

  20. [Anterior cruciate ligament-plasty using the "U-dos" technique].

    PubMed

    Morales-Trevizo, C; Paz-García, M; Leal-Berumen, I; Leal-Contreras, C; Berumen-Nafarrate, E

    2013-01-01

    The knee is a compound diarthrodial joint, vulnerable to serious injuries such as ligament injuries of: medial collateral ligament, lateral collateral ligament, anterior cruciate ligament and posterior cruciate ligament, as cruciate ligaments limit rotation movement in the joint. The purpose of our study was to create a new technique to treat injuries of the anterior cruciate ligament, which is composed of two bundles--anteromedial and posterolateral--trying to achieve an anatomical reconstruction that allows for a normal biomechanical recovery. This technique reduces the use of fixation material and costs. The diagnosis of anterior cruciate ligament injuries was made with the pivot shift test. There are currently two repair methods for anterior cruciate ligament injuries: single bundle or double bundle repair; none of these techniques is considered as the gold standard, as their results are very similar. This paper describes a technique used for the treatment of anterior cruciate ligament injuries, known as "U-dos", and its clinical results. Cross-sectional, observational study that enrolled 20 patients with total anterior cruciate ligament injuries who underwent anterior cruciate ligament plasty using the "U-dos" technique between June 2009 and June 2010. The technique requires the use of bone bank allograft, in this case of the anterior tibial ligament. Patients were assessed using the Lysholm scale and the pivot shift test. Our results show that all the pivot shift tests were negative and assessments according to the Lysholm scale were from normal to excellent in 95% of cases (19/20). Only one failure was reported, with avulsion of the graft attachment which required a surgical intervention.

  1. 48 CFR 653.217-70 - DOS form DS-1921, Award/Modification of Interagency Acquisition Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false DOS form DS-1921, Award...-1921, Award/Modification of Interagency Acquisition Agreement. As prescribed in 617.504-70(b)(5)(i), DS-1921 is prescribed for use when awarding or modifying Economy Act Interagency Acquisition...

  2. Endocrine disruptors in water filters used in the Rio dos Sinos Basin region, Southern Brazil.

    PubMed

    Furtado, C M; von Mühlen, C

    2015-05-01

    The activated carbon filter is used in residences as another step in the treatment of drinking water, based on a physical-chemical process to absorb pollutants that are not removed in conventional treatment. Endocrine disruptors (EDCs) are exogenous substances or mixtures of substances that acts on the endocrine system similarly to the endogenously produced hormones, triggering malfunctions and harmful changes to human and animal health. The objective of the present work was to study EDCs through semi-quantitative analysis of residential water filters collected in the region of Rio dos Sinos basin, focusing on two specific classes: hormones and phenols. The solid phase extraction principle was used for the extraction of compounds and gas chromatography coupled with mass spectrometry for the separation and characterization of EDCs. Four samples of residential filters collected from public water distribution and artesian wells, from the cities of Novo Hamburgo and São Leopoldo were analysed. Using the developed methodology, it was possible to detect and comparatively quantify selected EDCs in all studied samples, which indicates the presence of these contaminants in drinking water from different sources. PMID:26270219

  3. Environmental discrimination among soft-bottom mollusc associations off Lagoa dos Patos, South Brazil

    NASA Astrophysics Data System (ADS)

    Absalão, R. S.

    1991-01-01

    Sublittoral benthic molluscs established in the outlet of Lagoa dos Patos (South Brazil) were sampled with a rectangular dredge and the malacological associations delineated by cluster analysis (WPGA) using the Baroni-Urbani and Buser similarity index. Three main associations were characterized in bands parallel to the beach with relative concordance with specific sedimentological facies. The multiple discriminant analysis showed that there was a high correlation between these associations and the following environmental parameters: depth, average grain size, skewness of the sediment, medium sand, coarse sand, total sand and total mud. The effect of reducing the multidimensionality of the data to two factors, ecologically explained, brings out the importance of depth, average grain size, total sand and total mud. The first appears to be a bathymetric gradient of stability/disturbance; the disturbance from storms becomes less frequent with increasing depth. This is partially supported by the results of the Caswell neutral model, and is in agreement with the intermediate disturbance hypothesis predictions. The second sedimentological factor is the relative percentages of sand and mud in determining the specific composition of these associations.

  4. Geochemical and isotopic constraints on the tectonic setting of Serra dos Carajas belt, eastern Para, Brazil

    NASA Technical Reports Server (NTRS)

    Olszewski, W. J., Jr.; Gibbs, A. K.; Wirth, K. R.

    1986-01-01

    The lower part of the Serra dos Carajas belt is the metavolcanic and metasedimentary Grao para Group (GPG). The GPG is thought to unconformably overlie the older (but undated) Xingu Complex, composed of medium and high-grade gneisses and amphibolite and greenstone belts. The geochemical data indicate that the GPG has many features in common with ancient and modern volcanic suites erupted through continental crust. The mafic rocks clearly differ from those of most Archean greenstone belts, and modern MORB, IAB, and hot-spot basalts. The geological, geochemical, and isotopic data are all consistent with deposition on continental crust, presumably in a marine basin formed by crustal extension. The isotopic data also suggest the existence of depleted mantle as a source for the parent magmas of the GPG. The overall results suggest a tectonic environment, igneous sources, and petrogenesis similar to many modern continental extensional basins, in contrast to most Archean greenstone belts. The Hammersley basin in Australia and the circum-Superior belts in Canada may be suitable Archean and Proterozoic analogues, respectively.

  5. Geophysical maps of the Dos Cabezas Mountains Wilderness Study Area, Cochise County, Arizona

    USGS Publications Warehouse

    Abrams, G.A.

    1986-01-01

    In the Dos Cabezas Mountains the Apache Pass fault zone is the major structural feature, barely skirting the southwest side of the study area. It extends several miles to the northwest and tens of miles to the southeast, across the Chiricahua Mountains beyond Apache Pass. It is typically made up of a pair of bounding faults and some anastomosing faults between them. The study area is underlain by a variety of sedimentary, igneous, and metamorphic rocks that provide only a fragmentary record of geologic events between Precambrian and Holocene times. A suite of metamorphic and igneous (primarily crystalline) rocks forms the basement terrain. Paleozoic and Mesozoic sedimentary rocks and also Paleozoic and Mesozoic volcanic rocks overlie the basement rocks but are extensively eroded away and may be covered. A pile of volcanic rocks of Late Cretaceous and Paleocene age caps the older rocks in much of the study area. Mid-Tertiary intrusive rocks underlie the eastern part of the study area as well as some very small, widely scattered additional localities. Quaternary gravel deposits occur in the major valleys and along the mountain front.

  6. Hydra: a C-language environment for real-time DOS multitasking at the bedside.

    PubMed

    DeGaetano, A; Coleman, W P; Pizzi, R; Tomasella, E; Castagneto, M; Greco, A V

    1993-10-01

    Patient monitoring at the bedside is an inherently parallel job, best handled by multiple individual tasks running concurrently. Cost and diffusion considerations strongly favor the use of PC's at the bedside, but their most widespread operating system, DOS, is not built for multitasking. Hence, a software platform in C language has been prepared, allowing the intermediate programmer to easily write independent modules which will then run simultaneously without conflicts. Such a platform aims at allowing effortless sharing of data among concurrently running processes, while providing strong insulation between tasks, enough to allow multiple copies of any one task to run simultaneously unknown to each other. A cooperative, memory sharing multitasking paradigm has been chosen, which offers fine granularity of timeslicing and low execution overhead at the price of some loss in generality of design. Speed, data exchange capability and number of stackable windows are greater than with commercial packages like Windows or LabWindows. Dynamical reprioritization of tasks is built in, allowing the computerized monitor to focus its attention and resources on urgent tasks.

  7. Endocrine disruptors in water filters used in the Rio dos Sinos Basin region, Southern Brazil.

    PubMed

    Furtado, C M; von Mühlen, C

    2015-05-01

    The activated carbon filter is used in residences as another step in the treatment of drinking water, based on a physical-chemical process to absorb pollutants that are not removed in conventional treatment. Endocrine disruptors (EDCs) are exogenous substances or mixtures of substances that acts on the endocrine system similarly to the endogenously produced hormones, triggering malfunctions and harmful changes to human and animal health. The objective of the present work was to study EDCs through semi-quantitative analysis of residential water filters collected in the region of Rio dos Sinos basin, focusing on two specific classes: hormones and phenols. The solid phase extraction principle was used for the extraction of compounds and gas chromatography coupled with mass spectrometry for the separation and characterization of EDCs. Four samples of residential filters collected from public water distribution and artesian wells, from the cities of Novo Hamburgo and São Leopoldo were analysed. Using the developed methodology, it was possible to detect and comparatively quantify selected EDCs in all studied samples, which indicates the presence of these contaminants in drinking water from different sources.

  8. Urano y sus dos satélites irregulares recientemente descubiertos

    NASA Astrophysics Data System (ADS)

    Parisi, M. G.; Brunini, A.

    Hasta hace poco tiempo, Urano era el único de los Planetas Gigantes que no poseía satélites irregulares. Esto lo diferenciaba del resto de los planetas Gigantes, al igual que la peculiar oblicuidad de su eje de spin. La gran inclinación de su eje de rotación se debe probablemente a una colisión que sufrió el planeta con otro embrión planetario al final del proceso de formación. Esta colisión habría desligado satélites exteriores preexistentes del planeta. Recientemente se han descubierto dos satélites irregulares de Urano, lo que introduce algunas nuevas cotas y condiciones en el escenario de la "Hipótesis de la Gran Colisión" . Los satélites irregulares de Urano tuvieron que ser capturados en una etapa posterior a la del escenario de la Gran Colisión, de no ser así, hubieran sido eyectados del sistema por el impulso impartido con ese gran impacto. En este trabajo, se discuten los posibles mecanismos de captura de los satélites irregulares y se presenta un nuevo posible mecanismo para dicha captura.

  9. Creating a Global Fiducials Program (GFP) Site: Lago Cachet Dos example in Chile

    NASA Astrophysics Data System (ADS)

    Friesen, B. A.; Nimick, D. A.; Wilson, E. M.

    2012-12-01

    The USGS has been acquiring remotely sensed imagery from all over the world, collecting thousands of images at more than 200 sites, and creating Literal Image Derived Products (LIDPs) as part of the Global Fiducials Program (GFP). The GFP program enables scientists to use these images to study our rapidly changing planet at carefully selected locations around the world. New GFP Sites are created and added each year. Researchers at the University of Alaska, for instance, added areas susceptible to coastal erosion for monitoring the long-term effects of high tides and storms. This presentation will guide you through the process of creating a new GFP site for your area of interest. We will describe the components of the GFP and its archive, the Global Fiducials Library. The Global Fiducials Program—Initial Site Proposal form will be presented and we will show you how to complete each component in order to propose a new site. Lago Cachet Dos, a glacier-dammed lake in southern Chile, is currently being proposed as a new GFP site and will be used as the example for this exercise. In addition, USGS web sites will be used to illustrate how a long-term imagery record can tell a story and to demonstrate viewing and downloading the type of data that will be available online and free of charge through the GFP.

  10. Open Cluster Radial Velocity determination from observations at Observatório Pico Dos Dias

    NASA Astrophysics Data System (ADS)

    Faria, M. A. F.; Monteiro, H.; Dias, W. S.; Lépine, J. R. D.

    2014-10-01

    In studies of the dynamics of the Galactic disk, such as the determination of the speed of the spiral pattern and the permanence of stars in the spiral arms, it is crucial to know orbits obtained from proper motions, radial velocities and the potential of the Galaxy. Aiming to improve the statistics of our catalog of open clusters, maintained by our research group, we determined the radial velocity of stars belonging to a group of open clusters using spectra with a resolution of 4000, obtained at the Pico dos Dias Observatory (LNA) with the 1.60 m telescope and the Coudé spectrograph. We observed the open cluster's member stars and calculated their radial speeds using standard techniques. The stars were selected from our own database based on relevant information concerning the clusters, obtained by statistical analysis of their proper motions and/or their position in the HR's diagram. In this work, we present the detailed analysis of the data reduction and radial velocity determination using synthetic spectra from different libraries. Finally we present the open cluster's radial (and spacial) velocities.

  11. 32 CFR Appendix C to Part 197 - Procedures for the Department of State (DoS) Foreign Relations of the United States (FRUS) Series

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) Foreign Relations of the United States (FRUS) Series C Appendix C to Part 197 National Defense Department... 197—Procedures for the Department of State (DoS) Foreign Relations of the United States (FRUS) Series... the DoS for the FRUS series under Public Law No. 102-138. b. Request authorization from the CIA,...

  12. Lessons Learned from Sleep Education in Schools: A Review of Dos and Don'ts

    PubMed Central

    Blunden, Sarah; Rigney, Gabrielle

    2015-01-01

    Study Objectives: Sleep duration and quality are associated with negative neuropsychological and psychosocial outcomes in children and adolescents. However, community awareness of this is low and sleep education programs in schools are attempting to address this issue. Several studies now exist assessing the efficacy of these sleep education programs for improving sleep knowledge, sleep hygiene and sleep patterns. This paper presents these sleep education programs, most particularly, it presents the strengths and weaknesses of the current available studies in the hope that this can identify areas where future sleep education programs can improve. Methods: A systematic search of all school-based sleep education studies in adolescents was undertaken. Studies were scrutinized for author, teacher and participant comment regarding strengths and limitations of each study, which were then extracted and summarized. Results: Two specific types of sleep education programs emerged from the review, those that sought to change sleep behavior and those that sought simply to disseminate information. Issues that dictated the strength or weakness of a particular study including who delivers the program, the theoretical basis, the tools utilized to measure sleep patterns, the content, and their capacity to engage students were assessed. Sleep education was considered important by teachers, students and parents alike. Conclusions: Future sleep education programs need to take into account lessons learned from previous sleep education efforts in order to maximize the potential for sleep education programs to improve the sleep health of our young people. Commentary: A commentary on this article appears in this issue on page 595. Citation: Blunden S, Rigney G. Lessons learned from sleep education in schools: a review of dos and don'ts. J Clin Sleep Med 2015;11(6):671–680. PMID:25766709

  13. The Relationship between Older Drivers’ Performance on the Driving Observation Schedule (eDOS) and Cognitive Performance

    PubMed Central

    Koppel, Sjaan; Charlton, Judith; Langford, Jim; Vlahodimitrakou, Zafiroula; Di Stefano, Marilyn; Macdonald, Wendy; Mazer, Barbara; Gelinas, Isabelle; Vrkljan, Brenda; Marshall, Shawn

    2013-01-01

    Research question/Objective: The Driving Observation Schedule (eDOS) was developed for use in the Candrive/Ozcandrive five-year prospective study of older drivers to observe the driving behavior of older drivers and monitor changes in driving behaviors over time. The aim of this study is to describe participants’ driving performance during the eDOS driving task and investigate the association between driving performance and cognitive measures. Methods: A subset of Ozcandrive participants (n = 144, 104 male [72%], 40 female [28%], Mean age = 81.49 years, SD = 3.58 years, Range: 76 – 96 years) completed the eDOS driving task. Participants drove to their selected destinations (up to 4 locations), with observations of driving behaviors (both inappropriate and appropriate) recorded for specific driving maneuvers: intersection negotiation, lane-changing, merging, low speed maneuvers and maneuver-free driving. Driving behaviors (e.g. signalling, speed regulation, gap acceptance, lane position, ‘critical errors’) were scored by a trained observer and participants received an overall eDOS driving task score (Maximum = 100 points). Participants also completed a series of cognitive assessments as part of the Year 2 Candrive/Ozcandrive assessment protocols. Results: The overall eDOS driving task score was very high (M = 95.77; SD = 5.15; Range = 65.63 – 100). Detailed analyses of participants’ driving behavior revealed a high level of appropriate driving behavior (96%, n = 5,935 maneuvers), with few errors (4%, n = 252 maneuvers). While most participants’ performance on the cognitive assessments was high, some scores were below the criteria for cogntive impairment (BIC) according to conventional benchmarks: (MoCA: M = 26.56, SD = 2.12, Range = 19 – 30, % BIC = 28%; MMSE: M = 29.10, SD = 1.01, Range = 26–30, %BIC = 0%; Trails B: M = 111.66, SD = 43.53, Range = 50 – 301, %BIC = 6%). There was no significant relationship observed between participants

  14. Video movie making using remote procedure calls and 4BSD Unix sockets on Unix, UNICOS, and MS-DOS systems

    SciTech Connect

    Robertson, D.W.; Johnston, W.E.; Hall, D.E.; Rosenblum, M.

    1990-03-01

    We describe the use of the Sun Remote Procedure Call and Unix socket interprocess communication mechanisms to provide the network transport for a distributed, client-server based, image handling system. Clients run under Unix or UNICOS and servers run under Unix or MS-DOS. The use of remote procedure calls across local or wide-area networks to make video movies is addressed.

  15. Investigation of the relationship between protein-protein interaction and catalytic activity of a heme-regulated phosphodiesterase from Escherichia coli (Ec DOS) by protein microarray.

    PubMed

    Sasakura, Yukie; Kanda, Katsuhiro; Yoshimura-Suzuki, Tokiko; Matsui, Takuya; Fukuzono, Shinichi; Shimizu, Toru

    2005-07-19

    Ec DOS, a heme-regulated phosphodiesterase from Escherichia coli, is composed of an N-terminal heme-bound PAS domain and a C-terminal phosphodiesterase domain. The heme redox state in the PAS domain regulates Ec DOS phosphodiesterase activity. Interestingly, the isolated heme-bound PAS fragment enhances phosphodiesterase activity of full-length Ec DOS. The enhancement is also regulated by the heme redox state of the isolated PAS domain. In the present study, we used a newly developed protein microarray system to examine the relationship between catalytic activity and the interaction of full-length Ec DOS and the isolated PAS fragment. Adenosine 3',5'-cyclic monophosphate (cAMP), a substrate of the Ec DOS phosphodiesterase, was found to be indispensable for the interaction between Ec DOS and the PAS fragment, and two phosphodiesterase inhibitors, 3-isobutyl-methyl-xanthine and etazolate hydrochloride, hindered the interaction. In addition, an enzyme with a mutation in the putative cAMP-binding sites (H590 and H594) was unable to interact with Ec DOS and lacked enzymatic activity. These results strongly suggest a close relationship between Ec DOS phosphodiesterase activity and interaction with the isolated PAS fragment. Therefore, this study provides insights into the mechanism of how the isolated PAS domain activates Ec DOS, which has important implications for the general role of the isolated PAS domain in cells. Moreover, we found that multiple microscale analyses using the protein microarray system had several advantages over conventional affinity column methods, including the quantity of protein needed, the sensitivity, the variability of immobilized protein, and the time required for the experiment. PMID:16008345

  16. Research on a Denial of Service (DoS) Detection System Based on Global Interdependent Behaviors in a Sensor Network Environment

    PubMed Central

    Song, Jae-gu; Jung, Sungmo; Kim, Jong Hyun; Seo, Dong Il; Kim, Seoksoo

    2010-01-01

    This research suggests a Denial of Service (DoS) detection method based on the collection of interdependent behavior data in a sensor network environment. In order to collect the interdependent behavior data, we use a base station to analyze traffic and behaviors among nodes and introduce methods of detecting changes in the environment with precursor symptoms. The study presents a DoS Detection System based on Global Interdependent Behaviors and shows the result of detecting a sensor carrying out DoS attacks through the test-bed. PMID:22163475

  17. Análise dos Conceitos Astronômicos Apresentados por Professores de Algumas Escolas Estaduais Brasileiras

    NASA Astrophysics Data System (ADS)

    Voelzke, Marcos Rincon; Gonzaga, Edson Pereira

    2011-12-01

    A razão para o desenvolvimento deste trabalho baseia-se no fato de que muitos professores da Educação Básica (EB) não lidam com conceitos relacionados à astronomia, e quando o fazem eles simplesmente seguem livros didáticos que podem conter erros conceituais. Como é de conhecimento geral a astronomia é um dos conteúdos a serem ensinados na EB fazendo parte dos Parâmetros Curriculares Nacionais e das Propostas Curriculares do Estado de São Paulo, mas é um fato, que vários pesquisadores apontam, a existência de muitos problemas no ensino da astronomia. Com o propósito de minimizar algumas dessas deficiências foi realizado um trabalho de pesquisa com a utilização de questionários pré e pós pesquisa, para tanto foi desenvolvido um Curso de Extensão Universitária para professores da Diretoria de Ensino Regional (DE) que abrange Mauá, Ribeirão Pires e Rio Grande da Serra (no Estado de São Paulo) com os seguintes objetivos: levantar concepções alternativas; subsidiar os professores por meio de palestras, debates e workshops, e verificar o sucesso da aprendizagem após o curso, adotando-se como referência, para a análise dos resultados, os dicionários de Língua Portuguesa (FERREIRA, 2004) e Enciclopédico de Astronomia e Astronáutica (MOURĀO, 1995). Portanto, dezesseis questões foram aplicadas antes e após o curso, assim pode-se verificar após a pesquisa que 100,0% dos professores sabiam os nomes das fases da Lua, 97,0% entenderam que o Sistema Solar é composto por oito planetas, 78,1% foram capazes de explicar como ocorre um eclipse lunar, um eclipse solar e um solstício, 72,7% sabiam como explicar a ocorrência das estações do ano; 64,5% explicaram corretamente a ocorrência do equinócio, 89,7% foram capazes de definir adequadamente o termo cometa; 63,6% definiram asteróide, 54,5% meteoro, 58,1% galáxia, e 42,4% planeta. Os resultados obtidos indicam uma aprendizagem significativa por parte dos participantes.

  18. 32 CFR Appendix C to Part 197 - Procedures for the Department of State (DoS) Foreign Relations of the United States (FRUS) Series

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the DoS for the FRUS series under Public Law No. 102-138. b. Request authorization from the CIA, NSC.... Submit to the respective Agency a list of CIA and NSC documents copied and released to the...

  19. 32 CFR Appendix C to Part 197 - Procedures for the Department of State (DoS) Foreign Relations of the United States (FRUS) Series

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the DoS for the FRUS series under Public Law No. 102-138. b. Request authorization from the CIA, NSC.... Submit to the respective Agency a list of CIA and NSC documents copied and released to the...

  20. 32 CFR Appendix C to Part 197 - Procedures for the Department of State (DoS) Foreign Relations of the United States (FRUS) Series

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the DoS for the FRUS series under Public Law No. 102-138. b. Request authorization from the CIA, NSC.... Submit to the respective Agency a list of CIA and NSC documents copied and released to the...

  1. Rare earth elements in Angra dos Reis and Lewis Cliff 86010, two meteorites with similar but distinct magma evolutions

    NASA Technical Reports Server (NTRS)

    Crozaz, Ghislaine; Mckay, Gordon

    1990-01-01

    Data are presented on ion microprobe measurements of REE and selected trace element abundances in individual grains of merrillite, fassaite, olivine, kirschsteinite, and plagioclase of Lewis Cliff 86010 (LEW 86010) meteorite and in merrillite and fassaite grains of Angra dos Reis (ADOR). Results show a close relationship between the two meteorites and support a magmatic origin for LEW 86010. However, the measurements indicate that, despite numerous common characteristics, the two meteorites must have been produced in separate magmatic events involving similar but distinct processes and parent melts.

  2. Perfil de temperatura dos funis magnetosféricos de estrelas T Tauri com aquecimento alfvênico

    NASA Astrophysics Data System (ADS)

    Vasconcelos, M. J.

    2003-08-01

    Estrelas T Tauri Clássicas são objetos jovens circundados por discos de gás e poeira e que apresentam uma intensa atividade magnética. Seu espectro mostra linhas de emissão alargadas que são razoavelmente reproduzidas nos modelos de acresção magnetosférica. No entanto, o perfil de temperatura dos funis magnéticos é desconhecido. Aquecimento magnético compressional e difusão ambipolar foram considerados para estas estruturas, porém as temperaturas obtidas não são suficientes para explicar as observações. Neste trabalho, examinamos o aquecimento gerado pelo amortecimento de ondas Alfvén através de quatro mecanismos, os amortecimentos não-linear, turbulento, viscoso-resistivo e colisional como função da freqüência da onda. Inicialmente, a temperatura é ajustada para reproduzir as observações e o grau de turbulência requerido para que o mecanismo seja viável é calculado. Os resultados mostram que este é compatível com os dados observacionais. Apresentam-se, também, resultados preliminares do cálculo auto-consistente do perfil de temperatura dos funis, levando-se em conta fontes de aquecimento Alfvênica e fontes de resfriamento.

  3. Degradability of dimethyl terephthalate by Variovorax paradoxus T4 and Sphingomonas yanoikuyae DOS01 isolated from deep-ocean sediments.

    PubMed

    Wang, Yu Ping; Gu, Ji-Dong

    2006-08-01

    Two strains of bacteria were isolated from deep-ocean sediments of the South China Sea using enrichment culturing technique and they were identified as Sphingomonas yanoikuyae DOS01 (AY878409) and Variovorax paradoxus T4 (AY878410) based on 16S rRNA gene sequences. S. yanoikuyae DOS01 was only capable of transforming dimethyl terephthalate (DMTP) to monomethyl terephthalate (MMTP) without further degradation while V. paradoxus T4 exhibited ability in mineralizing DMTP as the sole source of carbon and energy. The biochemical pathway of DMTP degradation was through MMTP and terephthalic acid (TA) as major detectable degradation intermediates in the culture media by both microorganisms. V. paradoxus T4 utilized DMTP and MMTP via hydrolysis of diester and monoester in the initial steps in degradation as confirmed by total organic carbon analysis of the culture medium and esterase activity assay of the lysed cells and fraction. The specific hydrolysis activity of esterase induced by DMTP or MMTP showed that greater hydrolysis of p-nitrophenyl acetate by esterase induced by DMTP-grown cells than that induced by MMTP. Results of this research suggest that the cleavage of the two identical carboxylic ester groups of phthalate diester are carried out by highly specific esterases of the same bacteria in the environment.

  4. Contextual variation in young children’s observed disruptive behavior on the DB-DOS: implications for early identification

    PubMed Central

    Petitclerc, Amélie; Briggs-Gowan, Margaret J.; Estabrook, Ryne; Burns, James L.; Anderson, Erica L.; McCarthy, Kimberly J.; Wakschlag, Lauren S.

    2015-01-01

    Background Contextual variation in child disruptive behavior is well documented but remains poorly understood. We first examine how variation in observed disruptive behavior across interactional contexts is associated with maternal reports of contextual variation in oppositional-defiant behavior and functional impairment. Second, we test whether child inhibitory control explains the magnitude of contextual variation in observed disruptive behavior. Methods Participants are 497 young children (mean age = 4 years, 11 months) from a subsample of the MAPS, a sociodemographically diverse pediatric sample, enriched for risk of disruptive behavior. Observed anger modulation and behavioral regulation problems were coded on the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS) during interactions with parent and examiner. Oppositional-defiant behavior, and impairment in relationships, with parents and nonparental adults, were measured with the Preschool Age Psychiatric Assessment (PAPA) interview with the mother. Functional impairment in the home and out-and-about was assessed with the Family Life Impairment Scale (FLIS), and expulsion from child care/school was measured with the baseline survey and FLIS. Results Observed disruptive behavior on the DB-DOS Parent Context was associated with oppositional-defiant behavior with parents, and with impairment at home and out-and-about. Observed disruptive behavior with the Examiner was associated with oppositional-defiant behavior with both parents and nonparental adults, impairment in relationships with nonparental adults, and child care/school expulsion. Differences in observed disruptive behavior in the Parent versus Examiner Contexts was related to the differences in maternal reports of oppositional-defiant behavior with parents versus nonparental adults. Children with larger decreases in disruptive behavior from Parent to Examiner Context had better inhibitory control and fewer attention

  5. [The Arabic influence in the "Colóquios dos simples e drogas da India" of Garcia da Orta].

    PubMed

    Ricordel, Joëlle

    2015-09-01

    The "Colóquios dos simples e drogas he cousas medicinais de Índia" (Conversations on the simples, drugs and medicinal substances of India) (1563) of Garcia da Orta is a botanical and pharmacognosy book. The author is a Portuguese physician who studied in the Spanish universities and practiced medicine mainly in India. He studies in short chapters presented in the form of dialogues about sixty simples. Sources to which he refers are indicative of a "classical" training, but also the mark of a curious and open mind to different cultures. The Arabic sources are numerous and mainly concern the identification of substances by abundant synonyms of their names in foreign languages and different medicinal uses that may have been done by the ancient physicians. However, Da Orta is critical with respect to these sources, seeking contradictions and differences of opinion among authors. He confronts them with the oral information collected thanks to a wide network of contacts. PMID:26529894

  6. [The Arabic influence in the "Colóquios dos simples e drogas da India" of Garcia da Orta].

    PubMed

    Ricordel, Joëlle

    2015-09-01

    The "Colóquios dos simples e drogas he cousas medicinais de Índia" (Conversations on the simples, drugs and medicinal substances of India) (1563) of Garcia da Orta is a botanical and pharmacognosy book. The author is a Portuguese physician who studied in the Spanish universities and practiced medicine mainly in India. He studies in short chapters presented in the form of dialogues about sixty simples. Sources to which he refers are indicative of a "classical" training, but also the mark of a curious and open mind to different cultures. The Arabic sources are numerous and mainly concern the identification of substances by abundant synonyms of their names in foreign languages and different medicinal uses that may have been done by the ancient physicians. However, Da Orta is critical with respect to these sources, seeking contradictions and differences of opinion among authors. He confronts them with the oral information collected thanks to a wide network of contacts.

  7. Another new and threatened species of lancehead genus Bothrops (Serpentes, Viperidae) from Ilha dos Franceses, Southeastern Brazil.

    PubMed

    Barbo, Fausto E; Gasparini, João Luiz; Almeida, Antonio P; Zaher, Hussam; Grazziotin, Felipe G; Gusmão, Rodrigo B; Ferrarini, José Mário G; Sawaya, Ricardo J

    2016-01-01

    A new insular species of the genus Bothrops is described from Ilha dos Franceses, a small island off the coast of Espírito Santo State, in southeastern Brazil. The new species differs from mainland populations of B. jararaca mainly by its small size, relative longer tail, relative smaller head length, and relative larger eyes. The new species is distinguished from B. alcatraz, B. insularis and B. otavioi by the higher number of ventral and subcaudal scales, relative longer tail and smaller head. The new species is highly abundant on the island, being nocturnal, semiarboreal, and feeding on small lizards and centipeds. Due its unique and restricted area of occurrence, declining quality of habitat, and constant use of the island for tourism, the new species may be considered as critically endangered. PMID:27394563

  8. NGC 2287: Un cúmulo abierto rico en binarias espectroscópicas de dos espectros

    NASA Astrophysics Data System (ADS)

    Levato, H.; Malaroda, S.; García, B.; Grosso, M.

    NGC 2287 contiene 100 estrellas con buena fotometría y 40 con tipos MK. En 1979 Levato et al., usando la técnica de la clasificación espectral, descubrieron que la mayoría de las estrellas en el rango B8-A0 eran binarias espectroscópicas con una inusual proporción de binarias con dos espectros. El presente proyecto tuvo el propósito de confirmar la naturaleza binaria de los miembros del cúmulo. Hemos obtenido espectros con resolución 14000 de 15 estrellas clasificadas como binarias. Los espectros, que abarcan la región λ 3500-λ 6000 Å, permitieron confirmar la naturaleza binaria de varias de las estrellas en la muestra. Hacemos notar el considerable interés astrofísico de este cúmulo abierto.

  9. Application of geostatistical methods to arsenic data from soil samples of the Cova dos Mouros mine (Vila Verde-Portugal).

    PubMed

    Reis, A P; Sousa, A J; Da Silva, E Ferreira; Fonseca, E Cardoso

    2005-09-01

    A total of 286 soil samples were collected in the Cova dos Mouros area. All samples were dry sieved into the <200 mesh size fraction and analysed for Fe, Cu, Zn, Pb, Co, Ni, Bi and Mn by atomic absorption spectrometry (AAS) and for As, Se, Sb and Te by atomic absorption spectrometry-hydrid generation (AAS-HG). Only the results of arsenic are discussed in this paper although the survey was extended to all analysed chemical elements. The purpose of this study was to make a risk probability mapping for arsenic that would allow better knowledge about the vulnerability of the soil to arsenic contamination. To achieve this purpose, the initial variable was transformed into an indicator variable using as thresholds the risk-based standards (intervention values) for soils, as proposed by [Swartjes 1999. Risk based assessment of soil and groundwater quality in the Netherlands: Standards and remediation. J. Geochem. Explor.73 1-10]. To account for spatial structure, sample variograms were computed for the main directions of the sampling grid and a spherical model was fitted to each sample variogram (arsenic variable and indicator variables). The parameters of the spherical model fitted to the arsenic variable were used to predict arsenic concentrations at unsampled locations. A risk probability mapping was also done to assess the vulnerability of the soil towards the mining works. The parameters of the spherical model fitted to each indicator variable were used to estimate probabilities of exceeding the corresponding threshold. The use of indicator kriging as an alternative to ordinary kriging for the soil data of Cova dos Mouros produced unbiased probability maps that allowed assessment of the quality of the soil.

  10. Projeto do sistema anti-ressonante da fiação dos transdutores para o detector Mario Schenberg

    NASA Astrophysics Data System (ADS)

    Vieira, S. J.., Jr.; Melo, J. L.

    2003-08-01

    O detector de ondas gravitacionais Mario Schenberg está sendo projetado e construído pelo grupo Gráviton. Sua construção está ocorrendo no Laboratório de Estado Sólido e Baixas Temperaturas (LESBT) da Universidade de São Paulo, na cidade de São Paulo. Esse detector possui uma massa ressonante esférica de cobre-alumínio, com 65 cm de diâmetro, pesando aproximadamente 1150 Kg, suspensa por um sistema de isolamento vibracional, que se encontra em fase de testes preliminares. A real eficácia desse sistema, entretanto, só poderá ser comprovada quando o detector estiver aparelhado com, pelo menos, um transdutor eletromecânico de altíssima sensibilidade acoplado à massa ressonante. Neste momento, não só este sistema de isolamento vibracional será posto em teste, como o do projeto da fiação que transporta os sinais de microondas até os transdutores e destes para a pré-amplificação. Apesar dessa fiação ter sido projetada para não apresentar nenhum contato com a superfície esférica da antena, de maneira a não haver nenhuma transmissão de ruído vibracional do laboratório para esta, deve-se minimizar o ruído microfônico produzido nessa fiação por oscilações mecânicas, uma vez que ela não utiliza nenhum sistema de isolamento vibracional. Com o intuito de resolver este problema, projetamos uma estrutura, formada por pequenos cilindros conectados por barras, a qual não terá nenhuma ressonância mecânica na faixa de freqüências de interesse para detecção (3000 - 3400 Hz). Desta forma, as vibrações nessa faixa não serão amplificadas. O projeto foi feito usando iterativamente, de maneira a otimizar os resultados obtidos, o programa de elementos finitos Msc/Nastran. Através de simulações feitas neste programa, determinamos os parâmetros geométricos ideais a serem utilizados, os quais proporcionam a maior região espectral de interesse livre de ressonâncias.

  11. Mycobacterium tuberculosis DosR is Required for Activity of the PmbtB and PmbtI Promoters under Hypoxia

    PubMed Central

    Schreuder, Lise J.; Parish, Tanya

    2014-01-01

    Mycobacterium tuberculosis has the ability to survive for extended periods of time under conditions of low oxygen, low pH, low iron and low nutrients. The mycobactins (M. tuberculosis siderophores) play a key role in scavenging iron from the environment and are induced in response to low iron in an IdeR-regulated manner. We demonstrate that the promoters of two mycobactin gene (mbt) operons are also expressed during adaptation to low oxygen, and that this expression is dependent on the DosR regulator. Up-regulation of mbt operons induced by low iron was not DosR-dependent. DosR is a member of a two component regulatory system which responds to oxygen availability. Deletion of the DosR regulator led to increased expression of bacterioferritin and increased capacity to grow under iron depletion. These data provide a link between the mycobacterial response to two conditions likely to be encountered in vivo, low iron and low oxygen. PMID:25211224

  12. Dynamics of the T cell response to Mycobacterium tuberculosis DosR and Rpf antigens in a Colombian population of household contacts of recently diagnosed pulmonary tuberculosis patients.

    PubMed

    Arroyo, Leonar; Rojas, Mauricio; Ortíz, Blanca L; Franken, Kees L M C; García, Luis F; Ottenhoff, Tom H M; Barrera, Luis F

    2016-03-01

    Immune response to DosR and Rpf antigens from Mycobacterium tuberculosis (Mtb) seems to be important for latency maintenance. Little is known about the dynamics of the immune response to these antigens in an endemic community. Thus, the IFNγ response and cytokine production in response to PPD, Esat6-Cfp10 (E6-C10), DosR and Rpf antigens in healthy HHC of tuberculosis (TB) patients over a 12 (T12) months period (short-term, stLTBI) was investigated. This response was compared with a group of LTBI, who have remained healthy for 5-7 years (long-term, ltLTBI). According to the IFNγ response, two groups of HHCs were identified in stLTBI in response to E6-C10. At T12, E6-C10(+) HHCs displayed a decrease in the IFNγ levels and a generalized decrease in cytokines production. The E6-C10(-) HHC showed an increase in the IFNγ response and cytokine levels. In stLTBI, the responses to E6-C10, DosR, and Rpf may be interpreted as a protective immune response controlling Mtb infection and may be leading to a state of latent infection. Comparing the response of stLTBI and ltLTBI, we observed significant changes in the proportions of CD45RO(+)CD27(+) T cells to specific DosR and Rpf, which may indicate a persistent immune response to Mtb antigens in ltLTBI.

  13. A DOS-based Version of the VICAR Image Processing System for Planetary Image Reduction, Navigation, and Measuring

    NASA Astrophysics Data System (ADS)

    Hockey, T.; Barnet, C.

    1994-05-01

    The Video Image Communication and Retrieval (VICAR) Image Processing System, developed by the JPL Multimission Image Processing Laboratory, has been a standard tool for analyzing space-probe images since the 1960s. VMS versions through 8.0 are available. Yet now, the advent of powerful, inexpensive microcomputers has made possible "desktop" image processing. Here, a set of software that parallels VICAR routines, and expands upon them, is presented, written for the DOS operating system. PC VICAR was written in Microsoft FORTRAN by Chris Barnet for use on a 386-based microcomputer. Other hardware requirements include a Wieland Systems Design PCIP100A board and a separate video monitor for use as a display device. A CD-ROM drive is a convenient way of accessing raw Voyager images in PDS format. PC VICAR was developed at New Mexico State University. An upgraded version is being tested at the University of Northern Iowa (UNI). This version accepts images in a variety of formats including Voyager, HST, Galileo, and those used with ground-based detectors. The software is user-friendly, and extra effort has been made to make the Voyager image-processing tasks simple and easy to understand. At UNI, we propose to provide other observers with image navigation and measurements of features associated with the collision of comet Shoemaker-Levy and Jupiter in July, 1994. Funding for this project was provided in part by the NASA/University Joint Venture (JOVE) Program.

  14. Groundwater radon, radium and uranium concentrations in Região dos Lagos, Rio de Janeiro State, Brazil.

    PubMed

    Almeida, R M R; Lauria, D C; Ferreira, A C; Sracek, O

    2004-01-01

    Ground water from Região dos Lagos, a coastal area of Rio de Janeiro state, was analysed for (226)Ra, (228)Ra, (222)Rn, (238)U, major ion concentrations, and physico-chemical parameters were also measured. Concentrations values ranged from <0.002 to 0.492 Bq l(-1) for (226)Ra, from <0.01 to 1.50 Bq l(-1) for (228)Ra and from < 1.0 x 10(-4) to 8.0 x 10(-2) Bq l(-1) for (238)U. Detectable (222)Rn concentrations (>3 Bq l(-1)) were found only in two samples. The spatial distribution of Ra concentration delineated one distinct area and some hot spots with high Ra concentration. Low pH value is the most important water parameter linked to high radium concentration. This is probably related to limited adsorption of radium on soil ferric oxides and hydroxides at low pH range. There was a significant correlation between uranium concentrations and electrical conductivity values, and also between uranium concentrations and concentrations of Ca, Mg, Na, K, and Cl, indicating sea water impact. Uranium concentrations were lower than maximum contaminant level for drinking water, whereas 17 out of the 88 ground water samples had levels of radium that exceeded the maximum contaminant level for tap water. The total annual effective dose for adult due to the water consumption reaches values up to 0.8 mSv.

  15. A new species of Rock-Dwelling Scinax Wagler (Anura: Hylidae) from Chapada dos Veadeiros, Central Brazil.

    PubMed

    Araujo-Vieira, Katyuscia; Brandão, Reuber Albuquerque; Faria, Daniele Carvalho Do Carmo

    2015-01-01

    A new species of the Scinax ruber clade is described from Chapada dos Veadeiros region, Central Brazil. The new species is diagnosed by having SVL 21.9-27.7 mm in males and 26.7-31.7 mm in females; snout acuminate in dorsal view and rounded in profile; medium-sized tympanum; vocal sac single, median, subgular, that does not reach the pectoral region; iris iridescent yellow, with some thin, darker reticulations; tadpoles with ventral oral disc; P-3 regular and unmodified as a labial arm; absence of keratinized and colored plates on the sides of the lower jaw-sheath; presence of a keratinized and colored spur on each side behind the lower jaw-sheath; dorsolateral eyes, ventrally invisible; and advertisement call composed of 8-14 notes each with 4-18 pulses, and duration of 290-420 ms. The new species uses temporary creeks in rock meadows above 1.000 m a.s.l. and males calls from rock outcrops. The dorsal color pattern enables this species to camouflage in this kind of surfaces.  PMID:25662110

  16. Effects of Unintentional Denial of Service (DOS) Due to Push-to-Talk (PTT) Delays on Performance of CSMA/CA Based Adhoc Land Mobile Radio (LMR) Networks

    NASA Astrophysics Data System (ADS)

    Navalekar, Abhijit C.; Michalson, William R.

    Unintentional Denial of Service (DOS) problems occur in wireless networks such as Wi-Fi due to factors such as signal capture, interference and have been studied extensively in the literature. A similar problem manifests amongst nodes within a LMR network due to different PTT delay characteristics. We first present the typical PTT delay values and distributions followed by an analytical model to estimate the denial of service problem. The results obtained using the model and simulations show that the LMR nodes experience DOS due to collisions resulting from PTT delays. The results also show that there exists an asymmetry in the performance of individual nodes and the extent of this asymmetry is a function of total number of nodes in the system and the density of nodes with similar PTT delay profiles. These observations have implications in both performance and capacity planning of an adhoc LMR network.

  17. Chemotaxis cluster 1 proteins form cytoplasmic arrays in Vibrio cholerae and are stabilized by a double signaling domain receptor DosM.

    PubMed

    Briegel, Ariane; Ortega, Davi R; Mann, Petra; Kjær, Andreas; Ringgaard, Simon; Jensen, Grant J

    2016-09-13

    Nearly all motile bacterial cells use a highly sensitive and adaptable sensory system to detect changes in nutrient concentrations in the environment and guide their movements toward attractants and away from repellents. The best-studied bacterial chemoreceptor arrays are membrane-bound. Many motile bacteria contain one or more additional, sometimes purely cytoplasmic, chemoreceptor systems. Vibrio cholerae contains three chemotaxis clusters (I, II, and III). Here, using electron cryotomography, we explore V. cholerae's cytoplasmic chemoreceptor array and establish that it is formed by proteins from cluster I. We further identify a chemoreceptor with an unusual domain architecture, DosM, which is essential for formation of the cytoplasmic arrays. DosM contains two signaling domains and spans the two-layered cytoplasmic arrays. Finally, we present evidence suggesting that this type of receptor is important for the structural stability of the cytoplasmic array. PMID:27573843

  18. Structural and electronic properties of protein/thiolate-protected gold nanocluster with ``staple'' motif: A XAS, L-DOS, and XPS study

    NASA Astrophysics Data System (ADS)

    Simms, Gordon A.; Padmos, J. Daniel; Zhang, Peng

    2009-12-01

    Following the recent breakthrough of total structural determination of a Au-thiolate nanocluster [P. Jadzinsky et al., Science 318, 430 (2007)], extensive interests have been stimulated to unveil (or revisit) the structure-property relationship of various thiolate-Au nanostructures in light of the new finding of -SR-(Au-SR)x- "staple" motif. Here, we present experimental x-ray absorption spectroscopy (XAS) and x-ray photoelectron spectroscopy (XPS) results on the local structure and electronic properties of thiolate-protected Au nanocluster encapsulated in bovine serum albumin (Au-BSA) together with theoretical calculation of projected local density of states (l-DOS) of Au25(SR)18 model cluster. Analysis of the Au L3-edge extended x-ray absorption fine structure (EXAFS) of Au-BSA suggested that the nanocluster is Au25 with Au-thiolate "staple" motif. X-ray absorption near-edge structure (XANES) and Au 4f XPS were used to probe the electronic behavior of Au-BSA. The Au d-electron density of Au-BSA was found to decrease by 0.047 e- relative to that of the bulk. A self-consistent real space Green's function approach implemented in ab initio FEFF8 program was used to calculate the l-DOS of Au25(SR)18 and other model clusters from a site-specific perspective. The theoretical results are in good agreement with the experimental d-DOS data of Au-BSA and, importantly, systematically illustrate the effect of Au-thiolate "staple" motif on the electronic behavior of Au25(SR)18. The present work sheds light on the structure-property relationship of thiolate-protected Au25 from both experimental and theoretical perspectives and illustrates the usefulness of XAS/l-DOS method in such studies.

  19. En la búsqueda de características en eyecciones coronales de masa que discriminen entre dos paradigmas físicos en modelos de ECMs

    NASA Astrophysics Data System (ADS)

    Paissan, G.; Stenborg, G.; Rovira, M.

    Se conocen tres diferentes fenómenos de gran escala que ocurren en la atmósfera solar, denominados eyecciones coronales de masa (ECMs), protuberancias eruptivas y grandes fulguraciones de dos bandas. Estos fenómenos están estrechamente relacionados y podrían ser distintas manifestaciones de un único proceso físico. Las ECMs son definidas como eyecciones de gran escala de masa y flujo magnético desde la baja corona al espacio interplanetario. Desde su descubrimiento en los '70, muchos modelos han sido propuestos para explicar su origen y evolución. La explicación física de las ECMs es un tema de debate intenso. No obstante, los modelos pueden sintetizarse en dos grandes grupos: 1) los modelos de inyección de flujo y 2) los modelos de almacenamiento y liberación. En este trabajo, se presentan los estudios realizados con una serie de eventos observados con el coronógrafo MICA (Mirror Coronograph for Argentina), el telescopio en H-alfa HASTA (H-alpha Solar Telescope for Argentina) y los coronógrafos C2 y C3 de la sonda SOHO (Solar and Heliospheric Observatory). Los eventos que pudieron ser identificados como ECMs son contrastados dentro del esquema de los dos paradigmas teóricos propuestos.

  20. Queda dos homicídios em São Paulo, Brasil: uma análise descritiva

    PubMed Central

    Peres, Maria Fernanda Tourinho; Vicentin, Diego; Nery, Marcelo Batista; de Lima, Renato Sérgio; de Souza, Edinilsa Ramos; Cerda, Magdalena; Cardia, Nancy; Adorno, e Sérgio

    2012-01-01

    Objetivo Descrever a evolução da mortalidade por homicídios no Município de São Paulo segundo tipo de arma, sexo, raça ou cor, idade e áreas de exclusão/inclusão social entre 1996 e 2008. Métodos Estudo ecológico de série temporal. Os dados sobre óbitos ocorridos no Município foram coletados da base de dados do Programa de Aprimoramento das Informações sobre Mortalidade, seguindo a Classificação Internacional de Doenças, Décima Revisão (CID-10). Foram calculadas as taxas de mortalidade por homicídio (TMH) para a população total, por sexo, raça ou cor, faixa etária, tipo de arma e área de exclusão/inclusão social. As TMH foram padronizadas por idade pelo método direto. Foram calculados os percentuais de variação no período estudado. Para as áreas de exclusão/inclusão social foram calculados os riscos relativos de morte por homicídio. Resultados As TMH apresentaram queda de 73,7% entre 2001 e 2008. Foi observada redução da TMH em todos os grupos analisados, mais pronunciada em homens (−74,5%), jovens de 15 a 24 anos (−78,0%) e moradores de áreas de exclusão social extrema (−79,3%). A redução ocorreu, sobretudo, nos homicídios cometidos com armas de fogo (−74,1%). O risco relativo de morte por homicídio nas áreas de exclusão extrema (tendo como referência áreas com algum grau de exclusão social) foi de 2,77 em 1996, 3,9 em 2001 e 2,13 em 2008. Nas áreas de alta exclusão social, o risco relativo foi de 2,07 em 1996 e 1,96 em 2008. Conclusões Para compreender a redução dos homicídios no Município, é importante considerar macrodeterminantes que atingem todo o Município e todos os subgrupos populacionais e microdeterminantes que atuam localmente, influenciando de forma diferenciada os homicídios com armas de fogo e os homicídios na população jovem, no sexo masculino e em residentes em áreas de alta exclusão social. PMID:21390415

  1. [Species from genus Eimeria observed in domestic rabbit (Oryctolagus cuniculus) feces raised at the Municipality of Campos dos Goytacazes in the State of Rio de Janeiro, Brazil].

    PubMed

    de Almeida, Adriana J; Mayen, Friederike L; de Oliveira, Francisco C R

    2006-01-01

    This study was designed to identify species of the genus Eimeria from eleven rabbit meat breeders from Campos dos Goytacazes. Fecal samples were collected from rabbits with different health conditions and consintence of feces. The following species of Eimeria were identified: E. perforans; E. magna; E. coecicola; E. irresidua; E. media; E. flavescens; E. nagpurensis; E. intestinalis, E. exigua and E. stiedae. Parasites from this genus were detected in 81.82% (9) of the rabbit meat production sites, regardless of the management and hygiene conditions. In all cases the infection was always caused from more than one species of Eimeria. PMID:17196120

  2. Detection of IgG1 antibodies against Mycobacterium tuberculosis DosR and Rpf antigens in tuberculosis patients before and after chemotherapy.

    PubMed

    Mattos, Ana Márcia Menezes; Chaves, Alexandre Silva; Franken, Kees L M C; Figueiredo, Bárbara Bruna Muniz; Ferreira, Ana Paula; Ottenhoff, Tom H M; Teixeira, Henrique Couto

    2016-01-01

    Diagnosis of tuberculosis (TB) remains challenging. Serum IgG1 antibodies against Mycobacterium tuberculosis active growth phase antigens (ESAT-6/CFP-10, Rv0717 and Rv3353), DosR regulon-encoded proteins (Rv1733, Rv1737, Rv2628 and Rv2029), and resuscitation-promoting factors (Rv0867 and Rv2389) were evaluated in TB patients using ELISA. Active TB patients showed elevated levels of IgG1 antibodies against ESAT-6/CFP-10, Rv0717, Rv3353, Rv1733, Rv2628, Rv2029 and Rv0867 in comparison to healthy controls (p < 0.001). These levels remained high after the initiation of treatment, while responses to Rv0717 and Rv1733 peaked early during treatment. IgG1 responses to ESAT-6/CFP-10, Rv3353, Rv2628, Rv2029 and Rv0867 declined to control levels after the completion of 6 months chemotherapy. ROC analysis confirmed the good diagnostic performance of Rv0717, Rv1733, Rv3353, Rv2628, Rv2029 and Rv0867antigens. These data suggest that detecting IgG1 antibodies against M. tuberculosis antigens, including DosR and Rpf proteins, may represent an additional tool in the diagnosis of tuberculosis.

  3. Mycobacterium tuberculosis DosR Regulon Gene Rv0079 Encodes a Putative, ‘Dormancy Associated Translation Inhibitor (DATIN)’

    PubMed Central

    Kumar, Ashutosh; Majid, Mohammad; Kunisch, Ralph; Rani, Pittu Sandhya; Qureshi, Insaf A.; Lewin, Astrid; Hasnain, Seyed E.; Ahmed, Niyaz

    2012-01-01

    Mycobacterium tuberculosis is a major human pathogen that has evolved survival mechanisms to persist in an immune-competent host under a dormant condition. The regulation of M. tuberculosis metabolism during latent infection is not clearly known. The dormancy survival regulon (DosR regulon) is chiefly responsible for encoding dormancy related functions of M. tuberculosis. We describe functional characterization of an important gene of DosR regulon, Rv0079, which appears to be involved in the regulation of translation through the interaction of its product with bacterial ribosomal subunits. The protein encoded by Rv0079, possibly, has an inhibitory role with respect to protein synthesis, as revealed by our experiments. We performed computational modelling and docking simulation studies involving the protein encoded by Rv0079 followed by in vitro translation and growth curve analysis experiments, involving recombinant E. coli and Bacille Calmette Guérin (BCG) strains that overexpressed Rv0079. Our observations concerning the interaction of the protein with the ribosomes are supportive of its role in regulation/inhibition of translation. We propose that the protein encoded by locus Rv0079 is a ‘dormancy associated translation inhibitor’ or DATIN. PMID:22719925

  4. Católicos, fidelidade conjugal e AIDS: entre a cruz da doutrina moral e as espadas do cotidiano sexual dos adeptos1

    PubMed Central

    Rios, Luis Felipe; de Aquino, Francisca Luciana; Muñoz-Laboy, Miguel; Oliveira, Cinthia; Parker, Richard

    2009-01-01

    Neste artigo discutimos a visão da Igreja Católica sobre sexualidade na interface com a epidemia do HIV/AIDS. Nossa reflexão está embasada em pesquisa etnográfica que envolveu dois meses de observação participante do cotidiano de católicos de um bairro popular da Região Metropolitana do Recife, além de contar com entrevistas a onze dos leigos engajados nos serviços religiosos da igreja do bairro e a oito sacerdotes que realizam seus trabalhos religiosos em outras localidades. Nelas abordamos diferentes temáticas relacionadas ao enfrentamento da epidemia da AIDS. Nesse contexto, conjugalidade e fidelidade se afiguram como importantes analisadores de como aqueles lidam com a epidemia, em uma variedade de re-descrições práticas e de re-interpretações conceptuais das assertivas do discurso moral religioso – ainda que, muitos impasses permaneçam em aberto em termos das prerrogativas da Igreja e seus possíveis rebatimentos na saúde sexual dos adeptos. PMID:21765650

  5. Qual o Papel da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos?

    NASA Astrophysics Data System (ADS)

    da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

    2007-08-01

    É amplamente reconhecido que as pessoas em geral têm grande fascínio e interesse pela Astronomia. Por outro lado, o conteúdo dessa área incluído no ensino formal está longe de ser abrangente e suficiente para suprir a demanda. Esse interesse permite aperfeiçoar a divulgação e o ensino não formal de Astronomia através da mídia aliando a adequação do conteúdo à expectativa das pessoas. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros tem introduzido Astronomia desde a pré-escola até o Ensino Médio. Num estudo realizado com 1180 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um formulário contendo questões que abordavam conhecimentos básicos em Astronomia, como foram adquiridos tais conhecimentos e à infra-estrutura da escola. Para 66,1% dos entrevistados o professor já fez alguma apresentação a respeito de Astronomia. O presente estudo revelou também que 54,4% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 18,4% através da televisão e 27,1% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, livros didáticos, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio no meio em que os alunos obtiveram seus conhecimentos astronômicos, a mídia busca não somente sua difusão, mas a disponibilização desse conhecimento de maneira correta, que às vezes, não é atingido, apresentando conceitos sem fundamentação e incorretos. Por outro lado, no dia-a-dia escolar, é comum encontrar professores que vêm para as aulas com concepções prévias, que podem diferir substancialmente das idéias a serem ensinadas, dificultando o aprendizado de futuros conceitos científicos. Uma avaliação criteriosa, avaliando as dificuldades dos professores em determinar o sentido correto dos conceitos e observando a metodologia que utilizam no ensino, poderá proporcionar uma melhor

  6. A Influência da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos

    NASA Astrophysics Data System (ADS)

    da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

    2006-08-01

    O universo em que vivemos possui segredos jamais imaginados pelo homem, fruto da pequena proporção que ocupamos diante de um cosmos infinito. A astronomia funciona como um instrumento que sacia a sede humana em desvendar esses segredos, estudando as galáxias, quasares, pulsares além da existência de todos os elementos que preenchem o espaço cósmico, o vácuo, não mais vazio como se pensou em outros tempos. A mídia explora esse campo de forma mística e também científica. A difusão adequada e dentro dos padrões educacionais vigentes, de conceitos astronômicos, se faz necessária, devido sua presença nos conteúdos escolares, centros de ciência e na mídia, de modo geral. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros introduziu conceitos astronômicos desde a pré-escola até o Ensino Médio. Num estudo realizado com 1.032 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um questionário que abordava conheciment os básicos em astronomia, como estes foram adquiridos e qual era a infra-estrutura oferecida pela escola: para 66,2% dos entrevistados o professor já fez alguma apresentação a respeito de astronomia. O presente estudo revelou também que 44,5% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 28,1% através da televisão e 27,4% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio na forma em que os alunos obtiveram seus conhecimentos astronômicos, a mídia ainda explora e muitas vezes desperta o interesse pela astronomia com assuntos que não fazem parte de nosso cotidiano como, por exemplo, o homem na Lua, os projetos espaciais e a primeira viagem de um astronauta brasileiro no espaço. Porém, em certos casos, a mídia pode promover conhecimentos incompletos ou mesmo equivocados sobre os conceitos que envolvam

  7. Geochemical and isotopic evidence for the petrogenesis and emplacement tectonics of the Serra dos Órgãos batholith in the Ribeira belt, Rio de Janeiro, Brazil

    NASA Astrophysics Data System (ADS)

    Machado, Rômulo; Philipp, Ruy Paulo; McReath, Ian; Peucat, Jean Jacques

    2016-07-01

    The Serra dos Órgãos batholith in the State of Rio de Janeiro (Brazil) is a NE-SW-trending elongated body that occupies ca. 5000 km2 in plan view. It is a foliated intrusion, especially at its borders and is crosscut by syn-magmatic shear zones, with foliations that are moderately-to steeply-dipping to the northwest and moderately-to shallow-dipping in the center and to the southeast, in a configuration of a large laccolith. It was emplaced between 560 and 570 Ma, during an extensional episode that was part of a series of events that comprise the Brasiliano Orogeny in SE Brazil, and which includes deformation, metamorphism and granite intrusion during the interval between 630 and 480 Ma. The two main rock types in the batholith are biotite-hornblende monzogranite, and biotite leucogranite, with subordinate tonalite, granodiorite, diorite, quartz diorite (enclaves), aplite and pegmatite. Harker-type diagrams help show two rock groups with similar trends of evolution: a dioritic and a granitic. The first one is tholeiitic, whereas the second is calc-alkaline, with medium-to high-K calc-alkaline affinity and metaluminous to slightly peraluminous character. In both groups strong decrease in Al2O3, MgO, FeOT and CaO relative to silica contents are observed, which is compatible with trends of fractional crystallization involving clinopyroxene and/or hornblende, plagioclase, opaque minerals, apatite, microcline and biotite. The Sr and Nd isotopic data suggest recycling of a Paleoproterozoic crust as an important petrological process to generate the batholith rocks. Geothermometry (amphibole composition) and geobarometry (saturation in zircon and apatite) indicate that most of the batholith solidified at mid to lower crustal levels at about 750 °C and between 5 and 5.5 kbar. We consider that Serra dos Órgãos crustal protoliths underwent melting caused by the interaction with hotter mafic magma at the base of the crust. These two magmas, with distinct initial

  8. A estabilidade dos PAHS em função da energia da radiação interestelar nas faixas UV e raios-X

    NASA Astrophysics Data System (ADS)

    Pinotti, R.; Costa, R. K.; Boechat-Roberty, H. M.; Lago, A.; Souza, G. B.

    2003-08-01

    A nebulosa CRL 618, uma proto-nebulosa planetária cuja nuvem molecular espessa envolve uma estrela B0, contém uma grande quantidade de C2H2 e CH4. Estas moléculas são consideradas os tijolos da criação de grandes moléculas carbonadas como os Hidrocarbonetos Policíclicos Aromáticos (PAHs). Esta nebulosa, por estar exposta a intensos campos de UV e Raios-X, é uma região de fotodissociação molecular que propicia a formação de novas moléculas, confirmada pela presença de C4H2 e C6H6 (Benzeno), que é a unidade básica dos PAHs. Atribui-se a esta família de moléculas orgânicas duas propriedades fundamentais, a resistência para sobreviver ao campo de radiação UV interestelar e a geração das bandas de emissão não identificadas (UIR) observadas no infravermelho. No entanto, alguns autores questionam a resistência dos PAHs ao campo de radiação UV interestelar. Empregando a técnica de Espectrometria de Massas por Tempo de Vôo, no modo de coincidência fotoelétron-fotoíon, estudamos a ionização e fragmentação das seguintes moléculas: Benzeno, Benzeno deuterado, Naftaleno, Antraceno e Fenantreno. Utilizamos uma fonte de Hélio monocromática em 21,21 eV (584,5 Å) e a radiação Síncroton do Laboratório Nacional de Luz Síncroton (LNLS) em diferentes energias nas proximidades da borda do C 1s ( 290 eV). Comprovamos a estabilidade dos PAHs sob ação de UV (21,21 eV), onde eles apresentam um baixo nível de fotodissociação, produzindo fragmentos ionizados com rendimento total na ordem de 5 por cento em relação ao íon molecular pai. Entretanto, em altas energias, na faixa de Raios-X, a quebra destas moléculas torna-se mais intensa, com a produção de muitos fragmentos. Como uma das rotas de fragmentação do Naftaleno é [(C10H8) = > (C6H6+) + (C4H2) + (e-)], e como temos as evidências observacionais da existência do C4H2 e C6H6 na nebulosa CRL 618, sugerimos que este ambiente também possui o Naftaleno.

  9. Mycobacterium tuberculosis DevR/DosR Dormancy Regulator Activation Mechanism: Dispensability of Phosphorylation, Cooperativity and Essentiality of α10 Helix

    PubMed Central

    Sharma, Saurabh; Tyagi, Jaya Sivaswami

    2016-01-01

    DevR/DosR is a well-characterized regulator in Mycobacterium tuberculosis which is implicated in various processes ranging from dormancy/persistence to drug tolerance. DevR induces the expression of an ~48-gene dormancy regulon in response to gaseous stresses, including hypoxia. Strains of the Beijing lineage constitutively express this regulon, which may confer upon them a significant advantage, since they would be ‘pre-adapted’ to the environmental stresses that predominate during infection. Aerobic DevR regulon expression in laboratory-manipulated overexpression strains is also reported. In both instances, the need for an inducing signal is bypassed. While a phosphorylation-mediated conformational change in DevR was proposed as the activation mechanism under hypoxia, the mechanism underlying constitutive expression is not understood. Because DevR is implicated in bacterial dormancy/persistence and is a promising drug target, it is relevant to resolve the mechanistic puzzle of hypoxic activation on one hand and constitutive expression under ‘non-inducing’ conditions on the other. Here, an overexpression strategy was employed to elucidate the DevR activation mechanism. Using a panel of kinase and transcription factor mutants, we establish that DevR, upon overexpression, circumvents DevS/DosT sensor kinase-mediated or small molecule phosphodonor-dependent activation, and also cooperativity-mediated effects, which are key aspects of hypoxic activation mechanism. However, overexpression failed to rescue the defect of C-terminal-truncated DevR lacking the α10 helix, establishing the α10 helix as an indispensable component of DevR activation mechanism. We propose that aerobic overexpression of DevR likely increases the concentration of α10 helix-mediated active dimer species to above the threshold level, as during hypoxia, and enables regulon expression. This advance in the understanding of DevR activation mechanism clarifies a long standing question as to

  10. Mycobacterium tuberculosis DevR/DosR Dormancy Regulator Activation Mechanism: Dispensability of Phosphorylation, Cooperativity and Essentiality of α10 Helix.

    PubMed

    Sharma, Saurabh; Tyagi, Jaya Sivaswami

    2016-01-01

    DevR/DosR is a well-characterized regulator in Mycobacterium tuberculosis which is implicated in various processes ranging from dormancy/persistence to drug tolerance. DevR induces the expression of an ~48-gene dormancy regulon in response to gaseous stresses, including hypoxia. Strains of the Beijing lineage constitutively express this regulon, which may confer upon them a significant advantage, since they would be 'pre-adapted' to the environmental stresses that predominate during infection. Aerobic DevR regulon expression in laboratory-manipulated overexpression strains is also reported. In both instances, the need for an inducing signal is bypassed. While a phosphorylation-mediated conformational change in DevR was proposed as the activation mechanism under hypoxia, the mechanism underlying constitutive expression is not understood. Because DevR is implicated in bacterial dormancy/persistence and is a promising drug target, it is relevant to resolve the mechanistic puzzle of hypoxic activation on one hand and constitutive expression under 'non-inducing' conditions on the other. Here, an overexpression strategy was employed to elucidate the DevR activation mechanism. Using a panel of kinase and transcription factor mutants, we establish that DevR, upon overexpression, circumvents DevS/DosT sensor kinase-mediated or small molecule phosphodonor-dependent activation, and also cooperativity-mediated effects, which are key aspects of hypoxic activation mechanism. However, overexpression failed to rescue the defect of C-terminal-truncated DevR lacking the α10 helix, establishing the α10 helix as an indispensable component of DevR activation mechanism. We propose that aerobic overexpression of DevR likely increases the concentration of α10 helix-mediated active dimer species to above the threshold level, as during hypoxia, and enables regulon expression. This advance in the understanding of DevR activation mechanism clarifies a long standing question as to the

  11. Pressure effects reveal that changes in the redox states of the heme iron complexes in the sensor domains of two heme-based oxygen sensor proteins, EcDOS and YddV, have profound effects on their flexibility.

    PubMed

    Anzenbacher, Pavel; Marchal, Stéphane; Palacký, Jan; Anzenbacherová, Eva; Domaschke, Thomas; Lange, Reinhard; Shimizu, Toru; Kitanishi, Kenichi; Stranava, Martin; Stiborová, Marie; Martinkova, Marketa

    2014-12-01

    The catalytic activity of a heme-based oxygen sensor phosphodiesterase from Escherichia coli (EcDOS) towards cyclic diGMP is regulated by the redox state of the heme iron complex in the enzyme's sensing domain and the association of external ligands with the iron center. Specifically, the Fe(II) complex is more active towards cyclic diGMP than the Fe(III) complex, and its activity is further enhanced by O2 or CO binding. In order to determine how the redox state and coordination of the heme iron atom regulate the catalytic activity of EcDOS, we investigated the flexibility of its isolated N-terminal heme-binding domain (EcDOS-heme) by monitoring its spectral properties at various hydrostatic pressures. The most active form of the heme-containing domain, i.e. the Fe(II)-CO complex, was found to be the least flexible. Conversely, the oxidized Fe(III) forms of EcDOS-heme and its mutants had relatively high flexibilities, which appeared to be linked to the low catalytic activity of the corresponding intact enzymes. These findings corroborate the suggestion, made on the basis of crystallographic data, that there is an inverse relationship between the flexibility of the heme-containing domain of EcDOS and its catalytic activity. The Fe(II)-CO form of the heme domain of a second heme-based oxygen sensor, diguanylate cyclase (YddV), was also found to be quite rigid. Interestingly, the incorporation of a water molecule into the heme complex of YddV caused by mutation of the Leu65 residue reduced the flexibility of this heme domain. Conversely, mutation of the Tyr43 residue increased its flexibility.

  12. Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

    PubMed

    Dockendorff, Chris; Faloon, Patrick W; Pu, Jun; Yu, Miao; Johnston, Stephen; Bennion, Melissa; Penman, Marsha; Nieland, Thomas J F; Dandapani, Sivaraman; Perez, José R; Munoz, Benito; Palmer, Michelle A; Schreiber, Stuart L; Krieger, Monty

    2015-01-01

    We report a new series of 8-membered benzo-fused lactams that inhibit cellular lipid uptake from HDL particles mediated by Scavenger Receptor, Class B, Type I (SR-BI). The series was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule Repository (NIH MLSMR), measuring the transfer of the fluorescent lipid DiI from HDL particles to CHO cells overexpressing SR-BI. The series is part of a previously reported diversity-oriented synthesis (DOS) library prepared via a build-couple-pair approach. Detailed structure-activity relationship (SAR) studies were performed with a selection of the original library, as well as additional analogs prepared via solution phase synthesis. These studies demonstrate that the orientation of the substituents on the aliphatic ring have a critical effect on activity. Additionally, a lipophilic group is required at the western end of the molecule, and a northern hydroxyl group and a southern sulfonamide substituent also proved to be optimal. Compound 2p was found to possess a superior combination of potency (av IC50=0.10μM) and solubility (79μM in PBS), and it was designated as probe ML312. PMID:25900219

  13. ASPECTS OF THE ECOLOGY OF PHLEBOTOMINES (Diptera: Psychodidae: Phlebotominae) IN AN AREA OF CUTANEOUS LEISHMANIASIS OCCURRENCE, MUNICIPALITY OF ANGRA DOS REIS, COAST OF RIO DE JANEIRO STATE, BRAZIL

    PubMed Central

    de Aguiar, Gustavo Marins; de Azevedo, Alfredo Carlos Rodrigues; de Medeiros, Wagner Muniz; Alves, João Ricardo Carreira; Rendeiro, Vanessa

    2014-01-01

    Over a complete two-year period, phlebotomine specimens were caught in an area of cutaneous leishmaniasis occurrence in the municipality of Angra dos Reis. A manual suction tube was used to catch phlebotomines on house walls, and also light traps in domestic and peridomestic settings and in the forest. This yielded 14,170 specimens of 13 species: two in the genus Brumptomyia and eleven in the genus Lutzomyia. L. intermedia predominantly in domestic and peridomestic settings, with little presence in the forest, with the same trend being found in relation to L. migonei, thus proving that these species have adapted to the human environment. L. fischeri appeared to be eclectic regarding location, but was seen to be proportionally more endophilic. L. intermedia and L. migonei were more numerous in peridomestic settings, throughout the year, while L. fischeri was more numerous in domestic settings except in March, April, May and September. From the prevalence of L. intermedia, its proven anthropophily and findings of this species naturally infected with Leishmania (Viannia) braziliensis, it can be incriminated as the main vector for this agent of cutaneous leishmaniasis in the study area, especially in the peridomestic environment. L. fischeri may be a coadjuvant in carrying the parasite. PMID:24626417

  14. Analysis of the Astronomical Concepts Presented by Teachers of Science, Physics, and Mathematics of São José dos Campos / SP Municipality

    NASA Astrophysics Data System (ADS)

    Pereira Gonzaga, Edson; Voelzke, Marcos Rincon

    2013-11-01

    The aim of this work is to conduct a survey of alternative conceptions about the basic concepts of Astronomy from schoolteachers in the City of São José dos Campos. This study covers the the state-run education system and complies with legal documents related to the curriculum of educational systems, such as the Curriculum of São Paulo State and the Parameters of the National Curriculum (PCN). Alternative conceptions, mentioned in Langhi (2009) as very important, were used, because it is believed that if a student can learn these concepts before the methodological intervention, it is possible to prepare contextualized presentations for teachers, and consequently students, to compare what they already know with the new information they obtain in the sessions at the digital mobile planetarium (DMP) of the Universidade Cruzeiro do Sul. Afterwards, they may discuss in a forum, in the form of debate, seeking to draw conclusions relevant to the topic, and transmitting the same to students in Basic Education (EB). This is a case study with a quantitative survey and a qualitative analysis of data on astronomical concepts collected through two questionnaires, one before and one after the intervention, respecting the implementation period of the study,- here called methodological intervention of content presentations at the mobile planetarium - and on respective discussions.

  15. A putative nitroreductase from the DosR regulon of Mycobacterium tuberculosis induces pro-inflammatory cytokine expression via TLR2 signaling pathway

    PubMed Central

    Peddireddy, Vidyullatha; Doddam, Sankara Narayana; Qureshi, Insaf A.; Yerra, Priyadarshini; Ahmed, Niyaz

    2016-01-01

    Tuberculosis caused by Mycobacterium tuberculosis is a global encumbrance and it is estimated that nearly one third population of the world acts as a reservoir for this pathogen without any symptoms. In this study, we attempted to characterise one of the genes of DosR regulon, Rv3131, a FMN binding nitroreductase domain containing protein, for its ability to alter cytokine profile, an essential feature of M. tuberculosis latency. Recombinant Rv3131 stimulated pro-inflammatory cytokines in THP-1 cells and human peripheral blood mononuclear cells in a time and dose dependent manner. In silico analyses using docking and simulations indicated that Rv3131 could strongly interact with TLR2 via a non-covalent bonding which was further confirmed using cell based colorimetric assay. In THP-1 cells treated with Rv3131 protein, a significant upsurge in the surface expression, overall induction and expression of mRNA of TLR2 was observed when analysed by flow cytometry, western blotting and real time PCR, respectively. Activation of TLR2 by Rv3131 resulted in the phosphorylation of NF- κβ. Results of this study indicate a strong immunogenic capability of Rv3131 elicited via the activation of TLR2 signalling pathway. Therefore, it can be surmised that cytokine secretion induced by Rv3131 might contribute to establishment of M. tuberculosis in the granulomas. PMID:27094446

  16. Aspects of the ecology of phlebotomines (Diptera: Psychodidae: Phlebotominae) in an area of cutaneous leishmaniasis occurrence, municipality of Angra dos Reis, coast of Rio de Janeiro State, Brazil.

    PubMed

    Aguiar, Gustavo Marins de; de Azevedo, Alfredo Carlos Rodrigues; Medeiros, Wagner Muniz de; Alves, João Ricardo Carreira; Rendeiro, Vanessa

    2014-01-01

    Over a complete two-year period, phlebotomine specimens were caught in an area of cutaneous leishmaniasis occurrence in the municipality of Angra dos Reis. A manual suction tube was used to catch phlebotomines on house walls, and also light traps in domestic and peridomestic settings and in the forest. This yielded 14,170 specimens of 13 species: two in the genus Brumptomyia and eleven in the genus Lutzomyia. L. intermedia predominantly in domestic and peridomestic settings, with little presence in the forest, with the same trend being found in relation to L. migonei, thus proving that these species have adapted to the human environment. L. fischeri appeared to be eclectic regarding location, but was seen to be proportionally more endophilic. L. intermedia and L. migonei were more numerous in peridomestic settings, throughout the year, while L. fischeri was more numerous in domestic settings except in March, April, May and September. From the prevalence of L. intermedia, its proven anthropophily and findings of this species naturally infected with Leishmania (Viannia) braziliensis, it can be incriminated as the main vector for this agent of cutaneous leishmaniasis in the study area, especially in the peridomestic environment. L. fischeri may be a coadjuvant in carrying the parasite. PMID:24626417

  17. Earth and Heavens: Two Separate Universes? (Spanish Title: Tierra y Cielos: ¿Dos Universos Separados?) Terra e Céus: Dois Universos Separados?

    NASA Astrophysics Data System (ADS)

    Carrascosa, Jaime; Gil-Pérez, Daniel; Solbes, Jordi; Vilches, Amparo

    2005-12-01

    complexidade, considerando, entre outros aspectos: as situações problemáticas relevantes que levaram à construção dos conhecimentos, as dificuldades de todo tipo que se teve que enfrentar nessa construção e, muito em particular,a necessidade de se superar as "evidências do senso comum" que estabeleciam uma suposta barreira intransponível entre a Terra e os Céus e que foram um obstáculo durante séculos para o desenvolvimento científico. Neste trabalho apresentamos um programa de atividades para o estudo da gravitação nos últimos anos do ensino médio, orientado a favorecer a participação dos estudantes, em alguma medida, na reconstrução deste processo que constituiu a denominada primeira grande revolução científica e a nos aproximarmos do estudo de uma das ciências mais antigas, a Astronomia, que hoje continua despertando grande interesse.

  18. Rb-Sr and Sm-Nd whole rock analyses of basalts of the Grao Para Group, Serra dos Carajas, Brazil

    SciTech Connect

    Olszewski, W.J. Jr.; Gibbs, A.K.; Wirth, K.R.

    1985-01-01

    The Grao Para Group at Serra dos Carajas in the Guapore Shield of Brazil is a 6 km thick sequence of bimodal metavolcanic rock with interbedded iron formations. Rhyolites are a minor part of the low grade meta-volcanic section, with the bulk consisting of subalkaline basalt, basaltic andesite, and shoshonite. Rb-Sr whole rock analyses of 7 basalts yield an age of 2687 +/- 54 Ma. This agrees well with an age of 2758 +/- 39 Ma from zircon U-Pb analyses of the interbedded rhyolites. Except for the allocthonous Imataca Complex of Venezuela, these dates for the Grao Para Group are the first well-constrained Archean ages from the Amazonian Craton. An even older age for the basement to the Grao Para Group is also implied. Sm-Nd whole-rock analyses of four of these basalts did not yield an isochron because of the limited range of /sup 147/Sm//sup 144/Nd values, but element of/sub Nd/ values relative to CHUR were calculated using the Rb-Sr age. The typical LREE-enrichment, lack of Ce depletion or spilitic alteration of alkalies, and the high Sr initial ratios, may indicate that these isotopic patterns were derived by incorporation of some older continental crust in the mafic melts. These data together with an element of/sub Sr/ of +63.6 might indicate significant seawater exchange with volcanic rocks derived from mantle with chondritic REE patterns. This demonstrates the presence of significant continental crust in the Archean and seawater-volcanic rock interaction in a rifting environment similar to modern analogs.

  19. Estudio fotométrico y espectroscópico de dos cúmulos abiertos jóvenes del disco con apariencia globular

    NASA Astrophysics Data System (ADS)

    Piatti, A. E.; Clariá, J. J.; Bica, E.

    Se presentan y discuten resultados obtenidos en el CASLEO y en el Observatorio de Las Campanas de dos cúmulos abiertos compactos con apariencia globular: Westerlund1 (BH197), ubicado en dirección hacia el centro galáctico, y Westerlund2. A partir de espectroscopía CCD integrada de ambos e imágenes CCD en las bandas VI obtenidas para el primero de ellos, se derivan sus parámetros fundamentales y se examinan sus apariencias estructurales. Se encuentra que Westerlund1 es un cúmulo joven (7 ± 3 millones de años), ubicado sobre el plano galáctico a 1.0 ± 0.4 kpc del sol, en una región caracterizada por una absorción excepcionalmente elevada (Av~=13.0 mag), en tanto que Westerlund2 es también un cúmulo joven (4-6 millones de años) ubicado sobre el plano, en una región afectada por una absorción menor (Av~=5.7 mag). Desde el punto de vista estructural, Westerlund 1 se presenta como uno de los pocos cúmulos abiertos jóvenes de la Galaxia con apariencia tipicamente globular, en contraste con los cúmulos azules de las Nubes de Magallanes en los cuales la apariencia globular constituye un fenómeno común. Westerlund2, aunque menos rico en estrellas, puede también ser incluído dentro de esta interesante clase de objetos.

  20. Techniques of remote sensing applied to the environmental analysis of part of an aquifer located in the São José dos Campos Region sp, Brazil.

    PubMed

    Bressan, Mariana Affonseca; Dos Anjos, Célio Eustáquio

    2003-05-01

    The anthropogenic activity on the surface can modify and introduce new mechanisms of recharging the groundwater system, modifying the tax, the frequency and the quality of recharge of underground waters. The understanding of these mechanisms and the correct evaluation of such modifications are fundamental in determining the vulnerability of groundwater contamination. The groundwater flow of the South Paraíba Compartment, in the region of São José dos Campos, São Paulo, is directly related to structural features of the Taubaté Basin and, therefore, the analysis of its behaviour enhances the understanding of tectonic structure. The methodology adopted for this work consists in pre-processing and processing of the satellite images, visual interpretation of HSI products, field work and data integration. The derivation of the main structural features was based on visual analysis of the texture elements of drainage, and the relief in sedimentary and crystalline rocks. Statistical analysis of the feature densities and the metric-geometric relations between the analysed elements have been conducted. The crystalline rocks, on which the sediments were laying, conditions and controls the structural arrangement of sedimentary formations. The formation of the South Paraíba Grabén is associated with Cenozoic distensive movement which reactivated old features of crust weakness and generated previous cycles with normal characteristics. The environmental analysis is based on the integration of the existing methodology to characterise vulnerability of an universal pollutant and density fracture zone. The digital integration was processed using GIS (Geographic Information System) to delineate five defined vulnerability classes. The hydrogeological settings were analysed in each thematic map and, using fuzzy logic, an index for each different vulnerability class was compiled. Evidence maps could be combined in a series of steps using map algebra.

  1. Diverging DOS strategy using an allene-containing tryptophan scaffold and a library design that maximizes biologically relevant chemical space while minimizing the number of compounds.

    PubMed

    Painter, Thomas O; Wang, Lirong; Majumder, Supriyo; Xie, Xiang-Qun; Brummond, Kay M

    2011-03-14

    A diverging diversity-oriented synthesis (DOS) strategy using an allene-containing tryptophan as a key starting material was investigated. An allene-yne substituted derivative of tryptophan 12 gave indolylmethylazabicyclooctadiene 17 when subjected to a microwave-assisted allenic [2 + 2] cycloaddition reaction. This same tryptophan-derived precursor afforded an indolylmethyldihydrocyclopentapyridinone 14 when subjected to a rhodium(I)-catalyzed cyclocarbonylation reaction and an indolylmethylpyrrolidinocyclopentenones 16 when reacted with molybdenum hexacarbonyl. Construction of allenic tetrahydro-β-carboline scaffolds via a Pictet-Spengler reaction and subsequent silver(I)-catalyzed cycloisomerization afforded tetrahydroindolizinoindoles (21). Attachment of allene and alkyne groups to the tetrahydro-β-carboline, followed by a microwave-assisted allenic [2 + 2] cycloaddition reaction, provided tetrahydrocyclobutaindoloquinolizinones 24 and the tetrahydrocyclopentenone indolizinoindolone 26 when reacted with molybdenum hexacarbonyl. These six scaffolds were used as templates for the construction of a virtual library of 11 748 compounds employing 44 indoles, 12 aldehydes, and 51 alkynes. Diversity analyses using a combination of cell-based chemistry space computations using BCUT (Burden (B) CAS (C) Pearlman at the University of Texas (UT)) metrics and Tanimoto coefficient (Tc) similarity calculations using two-dimensional (2D) fingerprints showed that the compounds in the virtual library occupied new chemical space when compared to the 327,000 compounds in the molecular libraries small molecule repository (MLSMR). A subset of fifty-three compounds was identified from the virtual library using the DVS package of Sybyl 8.0; this subset represents the most diverse compounds within the chemical space defined by these compounds and will be synthesized and screened for biological activity.

  2. Discovery of the base of the Pinal Schist and the Bear Canyon sequence below it in the eastern Metamorphic terrane of the Dos Cabezas mountains, Cochise County, Arizona

    SciTech Connect

    Erickson, R.C. . Geology Dept.)

    1993-04-01

    The eastern metamorphic terrane of the Dos Cabezas mountains is underlain by Pinal Schist (PS). Recent detailed mapping along the western edge of this terrane shows that a flat planar regional unconformity (UC) bounds this Pinal body at its western stratigraphic base. Below the UC lies 8 km[sup 2] of greenschist facies metapelites and metafelsites here given the provisional name of the Bear Canyon sequence (BCS). The PS above the UC is over 10 stratigraphic km, grading from 1 km conglomerate at the base (clasts are metafelsites and metasediments with very minor quartz and granite) up into 3 km of sandstones and then pelite, all with greenschist facies overprint. Relict bedding with abundant crossbedding is common; the sequence is upright. Foliation parallels bedding. Lineation is absent. The UC itself is well exposed in two places, on both sides of Happy Camp Canyon (HCC). On the west of HCC, the surface is exposed at the mouth of Bear Canyon (NW1/4 Sec. 31, T13S R28E) striking south and then southwest about 4 km, ending in the N center of Sec. 12, T14S R27E. The unconformity and the Pinal above it lie NS 30E in the north and smoothly swing to NE 50 SE in the south. Below the UC are 6 km[sup 2] of metasandstone and metafelsites of the BCS. The metasandstone is quartz-sericite schist with strong lineation ([minus]50 S70E) in its northern km of exposure. Bedding and foliation are NS 60 E in N, and NE 70 SE in S. This schist body is intruded on the E by a dike of quartz-phyric metafelsite to 1 km wide which underlies the UC along its entire length. The felsite shows strong relict flow layering and no foliation. Flow layering is NS 90 in the N, and strikes and dips variably in the S. A 1/4 km[sup 2] metafelsite plug intrudes the schist on the W, with flow layering NE 90. The two exposures of the UC are separated by a Precambrian normal fault striking N45E and dipping moderately SE under HCC alluvial fill; it has about a km of dip slip.

  3. Stratigraphy of fluvial sediment sequences and their palaeoenvironmental information in the foreland of the Serra dos Órgãos, southeastern Brazil

    NASA Astrophysics Data System (ADS)

    Kirchner, André; Nehren, Udo; Heinrich, Jürgen

    2013-04-01

    In the hinterland of Rio de Janeiro city the rivers Guapiaçu, Macacu and Iconha originate in the Serra dos Órgãos mountain range and drain into the Atlantic Ocean. Since their channelization in the 1950s, higher flow velocities caused an incision of the rivers into the valley fills. These circumstances provide the possibility to study the alluvial deposits along the streams during low water level and allow conclusions on palaeoenvironmental change and landscape history. Sedimentological investigations of 13 exposures as well as AMS 14C measurements were carried out to investigate sediment properties and reconstruct the sedimentation history within the floodplains. These results enable to distinguish three different facies units. A late Pleistocene Unit I can be detected at the base of the observed exposures and consists of clast-supported fine to coarse gravels. It can be assumed that the gravel bodies were formed by a climatically induced erosional-depositional cycle within a braided river system. The gravels are overlaid by Unit II, a grayish to bluish loam mainly of mid-Holocene age. During generally drier climates these loams have been deposited during high water stages or flooding events as a splay facies proximal to the rivers. A reduced flow competence and relatively stable morphodynamic conditions are assumed for that period. Unit III accumulated in the late Holocene typically consists of several meters of planar or cross bedded sands to fine gravels, interfingered by loamy inclusions, buried peat bogs and organic debris. Fining-upward sequences can be frequently studied within Unit III which were completed by loamy sediments in the uppermost parts of the exposures. The increased flow competence from Unit II to Unit III seems to be a fluvial response to the increased humidity of the late Holocene as well as the enhancement of El Niño-Southern Oscillation (ENSO). Heavy rainfall likely caused higher sediment supply from the steep slopes as well as a

  4. Geochemistry and petrogenesis of the Mesoarchean granites from the Canaã dos Carajás area, Carajás Province, Brazil: Implications for the origin of Archean granites

    NASA Astrophysics Data System (ADS)

    Feio, G. R. L.; Dall'Agnol, R.

    2012-12-01

    Four Mesoarchean (2.93 to 2.83 Ga) granite units, which encompass the Canaã dos Carajás, Bom Jesus, Cruzadão and Serra Dourada granites, were recognized in the Canaã dos Carajás area of the Archean Carajás Province. The Mesoarchean units are composed dominantly of biotite leucomonzogranites. They are compared with the Neoarchean Planalto suite (2.73 Ga) which encompasses biotite-hornblende monzogranites to syenogranites. The Canaã dos Carajás, Bom Jesus and the variety of the Cruzadão granite with higher (La/Yb)N are geochemically more akin to the calc-alkaline granites, whereas the other varieties of the Cruzadão granite are transitional between calc-alkaline and alkaline granites. The Serra Dourada granite has an ambiguous geochemical character with some features similar to those of calc-alkaline granites and other peraluminous granites. The Planalto granites have ferroan character, are similar geochemically to reduced A-type granites and show a strong geochemical contrast with the Mesoarchean studied granites. The Mesoarchean granites described in the Canaã dos Carajás area are geochemically distinct to those of the Rio Maria domain of the Carajás Province. The Canaã dos Carajás and Bom Jesus granites are similar to the high-Ca granites, whereas the Cruzadão and Serra Dourada are more akin to the low-CaO granites of the Yilgarn craton. The geochemical characteristics of the Mesoarchean studied granites approach those of the biotite granite group of Dharwar but the latter are enriched in HFSE and HREE compared to the Canaã dos Carajás granites. The Neoarchean Planalto suite granite has no counterpart in the Mesoarchean Rio Maria domain of the Carajás Province, neither in the Yilgarn and Dharwar cratons. Geochemical modeling suggests that partial melting of a source similar in composition to an Archean basaltic andesite of the Carajás Province could give origin to the Bom Jesus and Cruzadão granites. In the case of the Bom Jesus granite the

  5. Geochronological data from TTG-type rock associations of the Arroio dos Ratos Complex and implications for crustal evolution of southernmost Brazil in Paleoproterozoic times

    NASA Astrophysics Data System (ADS)

    Gregory, Tiago Rafael; Bitencourt, Maria de Fátima; Nardi, Lauro Valentim Stoll; Florisbal, Luana Moreira; Chemale, Farid, Jr.

    2015-01-01

    U-Pb isotope analyses by LA-MC-ICPMS (Laser Ablation - Multi Collector - Inductively Coupled Plasma Mass Spectrometry) in zircon crystals from metatonalites, tonalites and granodiorite gneiss from the Arroio dos Ratos Complex (ARC) early magmatism in southernmost Brazil are presented. The ARC is located in the eastern portion of the Sul-rio-grandense Shield, occurring as septa and roof pendants on granitoids emplaced along the Southern Brazilian Shear Belt (SBSB). The SBSB corresponds to a translithospheric structure composed of several anastomosed shear zones of dominantly transcurrent kinematics whose syntectonic magmatism, of Neoproterozoic age, is characteristic of post-collisional environments. The studied rocks comprise TTG-type associations with coeval mafic magmatism, deformed and metamorphosed within a ductile shear zone. Zircon crystals obtained from six samples are interpreted as igneous given that the crystals are subhedral to euhedral, bipyramidal, with concentric zonation, have ratios Th/U between 0.13 and 0.81 and have restricted evidence of overgrowth. The oldest Association 1 (A1) has structures compatible with recrystallization under conditions of high temperature and an igneous age of 2148 ± 33 Ma, obtained in a metatonalite. The rocks of Association 2 (A2) have similar compositions, although with a more significant coeval mafic fraction. They are intrusive into A1 and also show high-temperature recrystallization features. However, they are less deformed and partly preserve their primary, igneous fabric. The igneous ages obtained from two A2 tonalites are 2150 ± 28 Ma and 2136 ± 27 Ma. Association 3 (A3) is represented by tonalitic to granodioritic gneisses whose structure, composition and metamorphic features are similar to those of A1 rocks, except for the absence of coeval mafic magmas in the former. Local features resulting from partial melting are present in A3 rocks. Three samples from A3 were dated. A tonalitic gneiss gives igneous age

  6. Investigação dos perfís temporais de alta resolução de explosões solares tipo-III decimétricas

    NASA Astrophysics Data System (ADS)

    Cecatto, J. R.; Fernandes, F. C. R.; Sawant, H. S.; Madsen, F. R. H.

    2003-08-01

    Explosões solares tipo-III indicam a presença de feixes de elétrons acelerados durante "flares" solares. Sua investigação fornece informações tanto sobre os processos de aceleração de partículas quanto das características do agente causador e do local de aceleração. Explosões tipo-III decimétricas são geradas por feixes de elétrons viajando através de arcos magnéticos densos da baixa coroa solar. Os perfís temporais destes fenômenos, quando tomados com alta resolução, informam sobre os mecanismos de aceleração de partículas do feixe e o meio de transporte da energia liberada a partir da região de aceleração. Usando o Brazilian Solar Spectroscope (BSS), em operação no INPE, foram registradas dezenas de explosões tipo-III decimétricas, dentro da faixa de 2050-2250 MHz com alta resolução temporal (20 ms), em 13 de setembro de 2001, entre 13:00 e 16:10 UT. Foram selecionadas 10 explosões isoladas para uma investigação estatística detalhada de seus perfís temporais, em todos os cerca de 50 canais de freqüência. Os resultados indicam que cerca de 70% dos perfís temporais são complexos tanto durante a subida quanto descida. Os 30% restantes indicam que os perfís da subida podem ser bem representados, na maioria dos casos, por um processo não-linear e uma parcela significativa por processos lineares. Os perfís temporais da descida são dominados por um decaimento não-linear. Neste trabalho, será efetuada uma análise dos perfís temporais, tanto durante a subida quanto descida do fluxo, para as explosões selecionadas, em termos dos prováveis mecanismos de aceleração e relaxamento. 2

  7. Determinação de elementos próprios dos asteróides troianos: comparação entre as teorias semi-analítica e sintética

    NASA Astrophysics Data System (ADS)

    Roig, F.; Beaugé, C.

    2003-08-01

    Além do cálculo semi-analítico de elementos próprios dos asteróides Troianos (Beaugé & Roig 2001, Icarus 153, 391), recentemente foi apresentado um novo conjunto destes elementos próprios determinado através de uma teoria sintética (Knenezevic & Milani 2003, comunicação pessoal). As bases de dados contendo estas determinações estão disponiveis na pagina web do Asteroid Dynamical Site (http://hamilton.dm.unipi.it/cgi-bin/astdys/astibo). Nesta comunicação apresentamos os primeiros resultados de um estudo comparativo entre ambos conjuntos de elementos próprios, analisando suas vantagens e desvantagens, assim como os limites de precisão de cada conjunto. Mostramos que os elementos próprios sintéticos são mais precisos que os smi-analíticos para grandes amplitudes de libração do ângulo s = l-lJup, embora acontece o contrario para os corpos cuja amplitude de libração é muito pequena. Finalmente discutimos a influencia destes erros na determinação de familias de asteroides e da estrutura resonante em torno dos pontos Lagrangeanos L4 e L5.

  8. Characterization of a cAMP responsive transcription factor, Cmr (Rv1675c), in TB complex mycobacteria reveals overlap with the DosR (DevR) dormancy regulon

    PubMed Central

    Ranganathan, Sridevi; Bai, Guangchun; Lyubetskaya, Anna; Knapp, Gwendowlyn S.; Peterson, Matthew W.; Gazdik, Michaela; C. Gomes, Antonio L.; Galagan, James E.; McDonough, Kathleen A.

    2016-01-01

    Mycobacterium tuberculosis (Mtb) Cmr (Rv1675c) is a CRP/FNR family transcription factor known to be responsive to cAMP levels and during macrophage infections. However, Cmr's DNA binding properties, cellular targets and overall role in tuberculosis (TB) complex bacteria have not been characterized. In this study, we used experimental and computational approaches to characterize Cmr's DNA binding properties and identify a putative regulon. Cmr binds a 16-bp palindromic site that includes four highly conserved nucleotides that are required for DNA binding. A total of 368 binding sites, distributed in clusters among ∼200 binding regions throughout the Mycobacterium bovis BCG genome, were identified using ChIP-seq. One of the most enriched Cmr binding sites was located upstream of the cmr promoter, and we demonstrated that expression of cmr is autoregulated. cAMP affected Cmr binding at a subset of DNA loci in vivo and in vitro, including multiple sites adjacent to members of the DosR (DevR) dormancy regulon. Our findings of cooperative binding of Cmr to these DNA regions and the regulation by Cmr of the DosR-regulated virulence gene Rv2623 demonstrate the complexity of Cmr-mediated gene regulation and suggest a role for Cmr in the biology of persistent TB infection. PMID:26358810

  9. Factores socio-económicos asociados a la percepción de situación socioeconómica entre adultos mayores de dos países latinoamericanos

    PubMed Central

    Brenes-Camacho, Gilbert

    2014-01-01

    El objetivo principal del artículo es estudiar la asociación entre la percepción subjetiva sobre la situación económica propia y una serie de medidas objetivas de bienestar socioeconómico –fuentes de ingresos, tenencia de vivienda, nivel educativo y transferencias familiares informales de dinero- entre adultos mayores de dos países Latinoamericanos: México y Costa Rica. Los datos se obtienen de las primeras rondas de dos encuestas sobre envejecimiento: CRELES para Costa Rica y ENASEM para México. La variable dependiente más importante se obtiene de las respuestas a las pregunta “¿Cómo califica su situación económica actual?” en Costa Rica y “¿Diría usted que su situación económica es…?” en México. Para ambas encuestas, las respuestas se codificaron en forma binaria; el código 0 representa las categorías Excelente, Muy buena y Buena, y el código 1 representa a las categorías Regular y Mala. Se encontró que el ingreso por jubilación es un importante determinante de la percepción de bienestar en ambos países. En Costa Rica, el ingreso del cónyuge y la tenencia de vivienda son importantes predictores de la percepción de bienestar, mientras que en México, los ingresos por transferencias están fuertemente asociados con dicha percepción. PMID:25360057

  10. Observações simultâneas no óptico e infravermelho próximo dos BL Lacs PKS 2005-489 e PKS 2155-304 em diversas escalas de tempo

    NASA Astrophysics Data System (ADS)

    Dominici, T. P.; Abraham, Z.; Galo, A. L.

    2003-08-01

    A existência de variações rápidas de brilho em alguns blazares é um fenômeno bem comprovado, mas até agora não sabemos ao certo quais são os mecanismos físicos envolvidos. A maior dificuldade é a ausência de observações multibanda simultâneas que poderiam fornecer vínculos aos modelos. Buscando colaborar com a discussão estudamos o comportamento de dois BL Lacs, PKS 2005-489 e PKS 2155-304, em relação à variabilidade em diversas escalas de tempo, de poucos minutos até vários meses, com observações simultâneas em seis bandas espectrais (óptico e infravermelho próximo). Para tanto dois telescópios do LNA foram utilizados em conjunto nas campanhas observacionais realizadas em 2001 e 2002, cujos resultados são apresentados aqui. As duas fontes apresentaram características bastante diferentes, inclusive em relação à existência de variabilidade nos índices espectrais. Particularmente, registramos a primeira detecção de variações em escalas de tempo da ordem de poucos minutos em PKS 2005-489, com evidências da presença de um atraso entre as curvas de luz nas bandas V e R e a variação em R ocorrendo antes (o contrário do esperado no modelo de shock-in-jet). Em PKS 2155-304 detectamos pela primeira vez variabilidade em escalas de tempo de poucos minutos no infravermelho em um AGN. As observações indicam que as variações de brilho em blazares são o resultado da ação de mais de um fenômeno, especialmente em escalas de tempo muito curtas. Alguns cenários físicos são sugeridos para explicar os resultados observacionais.

  11. Tritium ((3)H) as a tracer for monitoring the dispersion of conservative radionuclides discharged by the Angra dos Reis nuclear power plants in the Piraquara de Fora Bay, Brazil.

    PubMed

    de Carvalho Gomes, Franciane; Godoy, José Marcus; de Carvalho, Zenildo Lara; de Souza, Elder Magalhães; Rodrigues Silva, José Ivan; Tadeu Lopes, Ricardo

    2014-10-01

    Presently, two nuclear power plants operate in Brazil. Both are located at Itaorna beach, Angra dos Reis, approximately 133 km from Rio de Janeiro city. The reactor cooling circuits require the input of seawater, which is later discharged through a pipeline into the adjacent Piraquara de Fora Cove. The radioactive effluents undergo ion-exchange treatment prior to their release in batches, causing the enrichment of (3)H relative to other radionuclides in the discharged waters. Under steady state conditions, the (3)H gradient in the Piraquara de Fora waters can be used to determine the dependence of the dilution factor on the distance from the discharge point. The present work describes experiments carried out at the reactor site during batch release episodes, including time series sampling at the discharge point and surface seawater sampling every 250 m to a distance of 1250 m, after a double distillation, the (3)H concentration was measured by liquid scintillation counting applying a Quantulus liquid scintillation spectrometer. The obtained results showed a linear relationship between the (3)H concentration and distance from the discharge point. At 1250 m from the discharge point a dilution index of 1:15 was measured which fits the expected value based on modeling.

  12. DOS/Russian - US program overview

    SciTech Connect

    Pifer, M.L.

    1996-04-01

    This paper describes the organization and describes the objectives for the science and technology agreements between the U.S.A. and Russia. The Gore-Chernomyrdin Commission objectives and the Civilian Research and the Development Foundation for the Independent States of the former Soviet Union (CRDF) are discussed.

  13. 27 CFR 9.175 - Dos Rios.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... contour line and Poonkinny Road, proceed southerly and then easterly along the meandering 2,000-foot contour line to its intersection with the eastern boundary of section 2, T21N, R13W, immediately south of... then westerly along the meandering 2,000-foot contour line, crossing Big Water Canyon, Doghouse...

  14. 27 CFR 9.175 - Dos Rios.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... contour line and Poonkinny Road, proceed southerly and then easterly along the meandering 2,000-foot contour line to its intersection with the eastern boundary of section 2, T21N, R13W, immediately south of... then westerly along the meandering 2,000-foot contour line, crossing Big Water Canyon, Doghouse...

  15. 27 CFR 9.175 - Dos Rios.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... contour line and Poonkinny Road, proceed southerly and then easterly along the meandering 2,000-foot contour line to its intersection with the eastern boundary of section 2, T21N, R13W, immediately south of... then westerly along the meandering 2,000-foot contour line, crossing Big Water Canyon, Doghouse...

  16. 27 CFR 9.175 - Dos Rios.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... contour line and Poonkinny Road, proceed southerly and then easterly along the meandering 2,000-foot contour line to its intersection with the eastern boundary of section 2, T21N, R13W, immediately south of... then westerly along the meandering 2,000-foot contour line, crossing Big Water Canyon, Doghouse...

  17. Scheduling Software for MS-DOS Microcomputers.

    ERIC Educational Resources Information Center

    Carlson, David H.; Prior, Barbara

    1991-01-01

    Identifies four microcomputer-based software packages for scheduling and evaluates their usefulness for scheduling employees in a library setting. Evaluation criteria are applied to (1) Schedule Master, from Schedule Master Corporation; (2) Schedule Plus, from Cyclesoft, Inc.; (3) Who Works When, from Newport Systems; and (4) Working Hours, from…

  18. Molecular Characterization of Human Pathogenic Bunyaviruses of the Nyando and Bwamba/Pongola Virus Groups Leads to the Genetic Identification of Mojuí dos Campos and Kaeng Khoi Virus

    PubMed Central

    Groseth, Allison; Mampilli, Veena; Weisend, Carla; Dahlstrom, Eric; Porcella, Stephen F.; Russell, Brandy J.; Tesh, Robert B.; Ebihara, Hideki

    2014-01-01

    Background Human infection with Bwamba virus (BWAV) and the closely related Pongola virus (PGAV), as well as Nyando virus (NDV), are important causes of febrile illness in Africa. However, despite seroprevalence studies that indicate high rates of infection in many countries, these viruses remain relatively unknown and unstudied. In addition, a number of unclassified bunyaviruses have been isolated over the years often with uncertain relationships to human disease. Methodology/Principal Findings In order to better understand the genetic and evolutionary relationships among orthobunyaviruses associated with human disease, we have sequenced the complete genomes for all 3 segments of multiple strains of BWAV (n = 2), PGAV (n = 2) and NDV (n = 4), as well as the previously unclassified Mojuí dos Campos (MDCV) and Kaeng Khoi viruses (KKV). Based on phylogenetic analysis, we show that these viruses populate 2 distinct branches, one made up of BWAV and PGAV and the other composed of NDV, MDCV and KKV. Interestingly, the NDV strains analyzed form two distinct clades which differed by >10% on the amino acid level across all protein products. In addition, the assignment of two bat-associated bunyaviruses into the NDV group, which is clearly associated with mosquito-borne infection, led us to analyze the ability of these different viruses to grow in bat (RE05 and Tb 1 Lu) and mosquito (C6/36) cell lines, and indeed all the viruses tested were capable of efficient growth in these cell types. Conclusions/Significance On the basis of our analyses, it is proposed to reclassify the NDV strains ERET147 and YM176-66 as a new virus species. Further, our analysis definitively identifies the previously unclassified bunyaviruses MDCV and KKV as distinct species within the NDV group and suggests that these viruses may have a broader host range than is currently appreciated. PMID:25188437

  19. Impact of natural climate change and historical land use on vegetation cover and geomorphological process dynamics in the Serra dos Órgãos mountain range in Rio de Janeiro State, Brazil

    NASA Astrophysics Data System (ADS)

    Nehren, U.; Sattler, D.; Heinrich, J.

    2010-03-01

    The Serra dos Órgãos mountain range in the hinterland of Rio de Janeiro contains extensive remnants of the Atlantic Forest (Mata Atlântica) biome, which once covered about 1.5 million km² from Northeast to South Brazil and further inland to Paraguay and Argentina. As a result of historical deforestation and recent land use intensification processes today only 5 to 8% of the original Atlantic Forest remains. Despite the dramatic habitat loss and a high degree of forest fragmentation, the remnants are among the Earth’s most diverse habitats in terms of species richness. Furthermore, they are characterized by a high level of endemism. Therefore, the biome is considered a "hotspot of biodiversity". In the last years many efforts have been taken to investigate the Mata Atlântica biome in different spatial and time scales and from different scientific perspectives. We are working in the Atlantic Forest of Rio de Janeiro since 2004 and focus in our research particularly on Quaternary landscape evolution and landscape history. By means of landscape and soil archives we reconstruct changes in the landscape system, which are mainly the result of Quaternary climate variability, young tectonic uplift and human impact. The findings throw light on paleoecological conditions in the Late Quaternary and the impact of pre-colonial and colonial land use practices on these landscapes. In this context, a main focus is set on climate and human-driven changes of the vegetation cover and its consequences for the geomorphological process dynamics, in particular erosion and sedimentation processes. Research methods include geomorphological field studies, interpretation of satellite images, physical and chemical sediment and soil analyses as well as relative and absolute dating (Feo/Fed ratio and 14C dating). For the Late Quaternary landscape evolution, the findings are compared with results from paleoclimatic and paloecological investigations in Southeast and South Brazil using other

  20. ANÁLISE DA INSERÇÃO DOS TEMAS DE HUMANIDADES E ÉTICA, COM METODOLOGIA DE APRENDIZAGEM BASEADA EM PROBLEMAS, EM CURRICULO MÉDICO INTEGRADO EM ESCOLA PÚBLICA NO DISTRITO FEDERAL, BRASIL

    PubMed Central

    Novaes, Maria Rita Carvalho Garbi; Novaes, Luiz Carlos Garcez; Guilhem, Dirce; Lolas, Fernando; Silveira, Carla; Guiotti, Murilo

    2009-01-01

    Objetivo Realizar uma análise da inserção da ética e humanidades no currículo do Curso de Medicina da Escola Superior em Ciências da Saúde - ESCS, escola pública do Distrito Federal, Brasil, de forma a contribuir com o processo de gestão curricular. Metodologia O Estudo é de coorte e documental. Foram pesquisados 37 termos relacionados à ética e 36 referentes à humanização nos objetivos educacionais e conteúdo dos módulos temáticos, habilidades e atitudes e interação ensino-serviço-comunidade, de 1a a 4a série e no programa do internato no currículo (ano 2006) e no projeto pedagógico do Curso de Medicina (2001). Resultados Maior inserção da humanização, ética e bioética na 1a e 2a série, quando comparado à inserção na 3a e 4a série e no internato, (IC95%-α=0,034, pvalue=0,007). Unidade de habilidades e atitudes: freqüência das 3 temáticas no currículo da 1a a 4a séries (IC95%-α=0,026, pvalue=0,013). Quando comparada a inserção entre o internato e as quatro primeiras séries, observa-se que nestas a inserção da temática humanização é superior (IC95%-α=0,042, pvalue=0,029). Conclusão O currículo desenvolvido no ano de 2006 na ESCS apresentou correlação com o projeto pedagógico do curso e contemplou a temática de forma abrangente, em todas as séries e internato. PMID:20396594

  1. Dos Hermanas Chicanas: Overcoming Barriers to Professional Advancement

    ERIC Educational Resources Information Center

    Prospero, Moises

    2007-01-01

    Women and ethnic minorities face steep barriers to professional advancement, and those who rise to the executive level typically use a variety of strategies to overcome obstacles in their way. This study first reviewed the literature on barriers to professional advancement for women and ethnic minorities and the strategies that they report using…

  2. Exercise beyond menopause: Dos and Don'ts.

    PubMed

    Mishra, Nalini; Mishra, V N; Devanshi

    2011-07-01

    With a significant number of women belonging to the status of menopause and beyond, it is imperative to plan a comprehensive health program for them, including lifestyle modifications. Exercise is an integral part of the strategy. The benefits are many, most important being maintenance of muscle mass and thereby the bone mass and strength. The exercise program for postmenopausal women should include the endurance exercise (aerobic), strength exercise and balance exercise; it should aim for two hours and 30 minutes of moderate aerobic activity each week. Every woman should be aware of her target heart rate range and should track the intensity of exercise employing the talk test. Other deep breathing, yoga and stretching exercises can help to manage the stress of life and menopause-related symptoms. Exercises for women with osteoporosis should not include high impact aerobics or activities in which a fall is likely. The women and the treating medical practitioner should also be aware of the warning symptoms and contraindications regarding exercise prescription in women beyond menopause. The role of exercise in hot flashes, however, remains inconclusive. Overall, exercising beyond menopause is the only noncontroversial and beneficial aspect of lifestyle modification and must be opted by all. PMID:22408332

  3. Web-Based Mathematics: Some "Dos" and "Don'ts"

    ERIC Educational Resources Information Center

    Loong, Esther Yook-Kin

    2011-01-01

    This case study describes an "out of field" teacher's use of the Internet to teach a range of mathematical topics in a modified Year 8 mathematics class. It highlights the importance of three factors for implementing a discernible web-based teaching strategy: appropriate choice of web objects, effective "virtual" pedagogy, and technical support…

  4. Face mask ventilation--the dos and don'ts.

    PubMed

    Wood, Fiona E; Morley, Colin J

    2013-12-01

    Face mask ventilation provides respiratory support to newly born or sick infants. It is a challenging technique and difficult to ensure that an appropriate tidal volume is delivered because large and variable leaks occur between the mask and face; airway obstruction may also occur. Technique is more important than the mask shape although the size must appropriately fit the face. The essence of the technique is to roll the mask on to the face from the chin while avoiding the eyes, with a finger and thumb apply a strong even downward pressure to the top of the mask, away from the stem and sloped sides or skirt of the mask, place the other fingers under the jaw and apply a similar upward pressure. Preterm infants require continuous end-expiratory pressure to facilitate lung aeration and maintain lung volume. This is best done with a T-piece device, not a self-inflating or flow-inflating bag.

  5. Divorce Matters: Visitation Dos and Don'ts

    MedlinePlus

    ... your former spouse. • Don’t question your children’s loyalty. • Help make the transition from one home to ... Don’t spoil your children to buy their loyalty and love • Don’t let your children blackmail ...

  6. Los Dos Mundos: Rural Mexican Americans, Another America.

    ERIC Educational Resources Information Center

    Baker, Richard

    This book explores race relations between Mexican Americans and Anglo Americans in "Middlewest," a fictitious name for an actual rural Idaho community with the highest proportion of Mexican Americans in the state. Many Mexican Americans in this predominantly agricultural area are current or former migrant workers. The first chapter describes field…

  7. Exercise beyond menopause: Dos and Don’ts

    PubMed Central

    Mishra, Nalini; Mishra, V. N.; Devanshi

    2011-01-01

    With a significant number of women belonging to the status of menopause and beyond, it is imperative to plan a comprehensive health program for them, including lifestyle modifications. Exercise is an integral part of the strategy. The benefits are many, most important being maintenance of muscle mass and thereby the bone mass and strength. The exercise program for postmenopausal women should include the endurance exercise (aerobic), strength exercise and balance exercise; it should aim for two hours and 30 minutes of moderate aerobic activity each week. Every woman should be aware of her target heart rate range and should track the intensity of exercise employing the talk test. Other deep breathing, yoga and stretching exercises can help to manage the stress of life and menopause-related symptoms. Exercises for women with osteoporosis should not include high impact aerobics or activities in which a fall is likely. The women and the treating medical practitioner should also be aware of the warning symptoms and contraindications regarding exercise prescription in women beyond menopause. The role of exercise in hot flashes, however, remains inconclusive. Overall, exercising beyond menopause is the only noncontroversial and beneficial aspect of lifestyle modification and must be opted by all. PMID:22408332

  8. Evolution of the Astronomy Concepts Along Basic Education Cycle. (Breton Title: Evolução dos Conceitos de Astronomia no Decorrer da Educação Básica.) La Evolución de los Conceptos de Astronomía Durante la Educación Básica

    NASA Astrophysics Data System (ADS)

    Darroz, Luiz Marcelo; da Rosa, Cleci Werner; Becker da Rosa, Álvaro; Samudio Pèrez, Carlos Ariel

    2014-07-01

    learning of astronomy in basic education. Embora a astronomia seja considerada uma das ciências mais antigas da humanidade e ainda que a compreensão de seus conceitos tenha trazido enormes avanços para a Ciência e, consequentemente, para a sociedade, observa-se que uma parcela significativa de pessoas encontra-se à margem desses conhecimentos. De acordo com os Parâmetros Curriculares Nacionais para a Educação Básica, cabe à escola a difusão dos conceitos cientificamente corretos, entre eles os relacionados à área de astronomia. Pertinente a essa questão, apresenta-se uma pesquisa realizada com 140 estudantes do nono ano do ensino fundamental e com 120 estudantes da terceira série do ensino médio de quatro escolas da região de Passo Fundo/RS. Buscou-se averiguar, por meio de um questionário composto de questões abertas e de múltipla escolha, o conhecimento desse grupo de estudantes acerca de termos e fenômenos astronômicos básicos e, também, verificar se o índice de acertos cresce à medida que eles avançam nas diferentes e gradativas séries dos ensinos fundamental e médio. De modo geral, os resultados apresentados demonstram que o ensino de astronomia na educação básica enfrenta deficiências. Das 20 questões investigadas, em 17 os índices de acertos são semelhantes nas respostas dadas por estudantes de nível fundamental e médio, revelando que muitas concepções equivocadas permanecem ao longo da educação básica. Isso evidencia que tais temas não são - ou são pouco - abordados durante esses dois níveis de escolarização. Assim, conclui-se que a discussão dos conceitos relacionados com a astronomia deve receber maior ênfase na abordagem dos diferentes conteúdos, sendo necessária uma ação nacional em prol do seu ensino. Acredita-se que essa ação nacional deve estar apoiada em um pilar triplo de atores coletivos: comunidade científica, comunidade astronômica semiprofissional e comunidade escolar. Por fim, esse pilar seria

  9. Difficulties of First Years Elementary School Teachers with the Teaching of Astronomy. (Breton Title: Dificuldades de Professores dos Anos Iniciais do Ensino Fundamental em Relação ao Ensino da Astronomia. ) Dificultades de LOS Profesores de los Primeros Años de la Escuela Primaria en Relación a la Enseñanza de la Astronomía

    NASA Astrophysics Data System (ADS)

    Langhi, Rodolfo; Nardi, Roberto

    2005-12-01

    This paper reports Primary School teachers' discourses analysis about their difficulties related to the teaching of Astronomy. It reports partial data of a master's level research carried out in the last two years, named "An exploratory study for inserting Astronomy in primary school teachers' education" (LANGHI, 2004). The study took into consideration students' and teachers' common sense conceptions about astronomical phenomena, conceptual mistakes in textbooks, and Astronomy's suggestions given by the PCN (Parâmetros Curriculares Nacionais - The Brazilian National Curriculum Standards). The paper aims to characterize teachers' difficulties, in order to provide subsides to the implementation of an initial or continuing education program. This study is justified by the fact that courses plans like these only will be adapted to the teacher's (and students') reality, if there is a primary investigation about what the teachers really need to know about Astronomy. This fact was possible here by the enunciations interpretation of a teachers' sample using semi-structured interviews, according to discourse analysis procedures. The research outcomes show difficulties related to factors like: those of personal order, methodological, on teacher's formation, educational infrastructure and other related to information sources for educators. Este artigo, que relata as dificuldades de professores em relação ao ensino da Astronomia, faz parte de um estudo exploratório para a inserção da Astronomia na formação de professores dos anos iniciais do Ensino Fundamental. Esse estudo leva em consideração as concepções alternativas de alunos e professores sobre fenômenos astronômicos, os erros conceituais em livros didáticos e as sugestões de conteúdos de Astronomia constantes nos PCN (Parâmetros Curriculares Nacionais). Caracterizar as dificuldades dos professores é a questão central deste texto, apontando para o objetivo de contribuir com subsídios para um futuro

  10. Difficulties of First Years Elementary School Teachers with the Teaching of Astronomy. (Breton Title: Dificuldades de Professores dos Anos Iniciais do Ensino Fundamental em Relação ao Ensino da Astronomia. ) Dificultades de LOS Profesores de los Primeros Años de la Escuela Primaria en Relación a la Enseñanza de la Astronomía

    NASA Astrophysics Data System (ADS)

    Langhi, Rodolfo; Nardi, Roberto

    2005-12-01

    This paper reports Primary School teachers' discourses analysis about their difficulties related to the teaching of Astronomy. It reports partial data of a master's level research carried out in the last two years, named "An exploratory study for inserting Astronomy in primary school teachers' education" (LANGHI, 2004). The study took into consideration students' and teachers' common sense conceptions about astronomical phenomena, conceptual mistakes in textbooks, and Astronomy's suggestions given by the PCN (Parâmetros Curriculares Nacionais - The Brazilian National Curriculum Standards). The paper aims to characterize teachers' difficulties, in order to provide subsides to the implementation of an initial or continuing education program. This study is justified by the fact that courses plans like these only will be adapted to the teacher's (and students') reality, if there is a primary investigation about what the teachers really need to know about Astronomy. This fact was possible here by the enunciations interpretation of a teachers' sample using semi-structured interviews, according to discourse analysis procedures. The research outcomes show difficulties related to factors like: those of personal order, methodological, on teacher's formation, educational infrastructure and other related to information sources for educators. Este artigo, que relata as dificuldades de professores em relação ao ensino da Astronomia, faz parte de um estudo exploratório para a inserção da Astronomia na formação de professores dos anos iniciais do Ensino Fundamental. Esse estudo leva em consideração as concepções alternativas de alunos e professores sobre fenômenos astronômicos, os erros conceituais em livros didáticos e as sugestões de conteúdos de Astronomia constantes nos PCN (Parâmetros Curriculares Nacionais). Caracterizar as dificuldades dos professores é a questão central deste texto, apontando para o objetivo de contribuir com subsídios para um futuro

  11. Establishing the Empirical Relationship Between Non-Science Majoring Undergraduate Learners' Spatial Thinking Skills and Their Conceptual Astronomy Knowledge. (Spanish Title: Estableciendo Una Relación Empírica Entre el Razonamiento Espacial de los Estudiantes de Graduación de Carreras no Científicas y su Conocimento Conceptual de la Astronomía.) Estabelecendo Uma Relação Empírica Entre o RacioCínio Espacial dos Estudantes de Graduação EM Carreiras Não Científicas e Seu Conhecimento Conceitual da Astronomia

    NASA Astrophysics Data System (ADS)

    Heyer, Inge; Slater, Stephanie J.; Slater, Timothy F.

    2013-12-01

    The astronomy education community has tacitly assumed that learning astronomy is a conceptual domain resting upon spatial thinking skills. As a first step to formally identify an empirical relationship, undergraduate students in a non-major introductory astronomy survey class at a mediumsized, Ph.D. granting, mid-western US university were given pre- and post-astronomy conceptual diagnostics and spatial reasoning diagnostics, Instruments used were the "Test Of Astronomy Standards" and "What Do You Know?" Using only fully matched data for analysis, our sample consisted of 86 undergraduate non-science majors. Students' normalized gains for astronomy surveys were low at .26 and .13 respectively. Students' spatial thinking was measured using an instrument designed specifically for this study. Correlations between the astronomy instruments' pre- to post-course gain scores and the spatial assessment instrument show moderate to strong relationships suggesting the relationship between spatial reasoning and astronomy ability can explain about 25% of the variation in student achievement. La comunidad de educación en astronomía ha supuesto de forma tácita que el aprendizaje de la astronomía consiste en un dominio conceptual fundamentado en el razonamiento espacial. Como un primer paso para identificar formalmente una relación empírica entre estas dos cosas, utilizamos como muestra los estudantes de graduación de carreras no científicas de un curso experimental en una universidad norteamericana del medioeste de porte mediano con programa de Doctorado em curso, en el cual estos estudiantes se sometieron a un diagnóstico de razonamiento espacial y conceptos astronómicos antes e después del mismo. Las herramientas utilizadas fueron el Test Of Astronomy Standards (TOAST) y el cuestionario What do you know? Utilizando solo los datos completamente consistentes para este análisis, nuestra muestra consistió en 86 estudantes de graduación. Las mejoras, depués de

  12. Apparent Motion of the Sun, Shadows of Objects and Measurement of Time in the View of Seventh Grade Students of Middle School. (Breton Title: Movimento Aparente do Sol, Sombras dos Objetos e Medição do Tempo na Visão de Alunos do Sétimo Ano do Ensino Fundamental.) Movimiento Aparente del Sol, Sombras de los Objetos y Medición del Tiempo en la Visión de Estudiantes del Séptimo Grado del Ciclo Pirmario

    NASA Astrophysics Data System (ADS)

    Iria Machado, Daniel

    2013-07-01

    The apparent motion of the Sun on the celestial sphere and the behavior of the shadows of objects over time are observable phenomena in everyday life. However, students often do not have a proper understanding of such occurrences, and can even display misconceptions about them. Therefore, we performed a research in order to know students' notions about these subjects and to evaluate the contribution to their understanding brought about by an activity performed with an interactive sundial in an informal learning environment. We investigated the ideas of 43 students from the seventh grade of middle school by applying a test with open questions before and after an activity with an analemmatic sundial, conducted by a monitor. A significant proportion of students were initially unaware of most of the phenomena treated. The intervention performed helped the students to assimilate new concepts, providing the contact with new phenomena and to a lesser degree, the development of explanations about them, indicating an educational potential of this action. However, the contribution to the understanding of some of the ideas explored was small, pointing to the need to make additional observations, studies and discussions. O movimento aparente do Sol na esfera celeste e o comportamento das sombras dos objetos com o passar do tempo são fenômenos observáveis no dia a dia. No entanto, muitas vezes os estudantes não possuem uma compreensão adequada de tais ocorrências, podendo inclusive exibir concepções alternativas a seu respeito. Por isso, efetuou-se uma pesquisa com o intuito de conhecer as noções dos alunos sobre esses temas e avaliar a contribuição para seu entendimento propiciada por uma atividade feita com um relógio de Sol interativo, em um ambiente de ensino informal. Foram investigadas as ideias de 43 alunos do sétimo ano do Ensino Fundamental mediante a aplicação de um teste com questões abertas antes e depois de uma atividade com um relógio de Sol

  13. Sobre las soluciones acotadas del problema instantáneo de dos cuerpos

    NASA Astrophysics Data System (ADS)

    Altavista, C.

    La demostración se basa en el hecho de que las integrales del problema de los N-cuerpos admiten componentes en el campo complejo según las raíces n-ésimas de la unidad. Definida la matriz unitaria correspondiente, la fórmula de Cayley permite transformar la matriz unitaria en una matriz hermitiana. Utilizando como parámetros los cosenos direccionales de un sistema de coordenadas orbitales referidos a un sistema de referencia fijo, puede construirse, utilizando el operador hermitiano antes definido, una forma cuadrática cuyas raíces mínima y máxima definen las cotas respectivas de los movimientos de los mencionados cosenos direccionales.

  14. 33 CFR 101.505 - Declaration of Security (DoS).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., or between vessels in the case of a vessel-to-vessel activity, as to the respective security measures each must undertake during a specific vessel-to-facility interface, during a series of interfaces between the vessel and the facility, or during a vessel-to-vessel activity. (b) Details as to who...

  15. 33 CFR 101.505 - Declaration of Security (DoS).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., or between vessels in the case of a vessel-to-vessel activity, as to the respective security measures each must undertake during a specific vessel-to-facility interface, during a series of interfaces between the vessel and the facility, or during a vessel-to-vessel activity. (b) Details as to who...

  16. 33 CFR 105.245 - Declaration of Security (DoS).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... vessels subject to part 104, of this subchapter must sign and implement DoSs as required in (b)(1) and (2... with this section. (g) A copy of all currently valid continuing DoSs must be kept with the...

  17. Conditions of Collaboration: A Dean's List of Dos and Don'ts.

    ERIC Educational Resources Information Center

    Glotzbach, Philip A.

    2001-01-01

    Presents relational and structural conditions necessary to successful collaboration between college faculty and administrators. Relational conditions include "refuse to play zero-sum games" and "the most important power in a college is the power to persuade." Structural conditions include "clarify the roles of players" and "prefer a matrix…

  18. órbitas espectroscópicas de dos sistemas binarios tempranos usando correlaciones cruzadas bidimensionales

    NASA Astrophysics Data System (ADS)

    González, J. F.; Lapasset, E.

    We apply the two-dimensional cross-correlation technique TODCOR to derive spectroscopic orbits for the two B-type double-lined spectroscopic binaries HD 66066A and HD 315031, previously mentioned as blue straggler candidates of the open clusters NGC 2516 and NGC 6530, respectively. Reliable radial velocities for both components are measured even for orbital phases for which the separation between the spectral lines are about 0.5 times the quadratic sum of the full-width at half-maximum of the lines. Both binaries have circular orbits and the orbital periods are 1.67 and 1.38 days for HD 66066A and HD 315031, respectively. We calculate minimum masses with errors of 3-5% and obtain the projected radii from the line widths. We derive absolute stellar parameters which are consistent with the age and distance of the clusters. Both binary systems are formed by main-sequence stars and it is expected that they will experience mass-transfer between their components before the end of the core H-burning stage. HD 315031 is likely a triple system as suggested by the variation of the center-of-mass velocity.

  19. Dos Idiomas, Un Mundo. Dual Language Project. Title VII Biennial Evaluation Report, 1995-97.

    ERIC Educational Resources Information Center

    Ernest, Harishini M.; Gonzalez, Rosa M.

    This is an evaluation of the first 2 years of a 5-year comprehensive Bilingual Education grant funded by Title VII Part A of the Improving America's Schools Act of 1994 in the Austin Independent School District (AISD) (Texas). The grant awarded to the AISD funds a program of Developmental Bilingual Education at two elementary schools where more…

  20. Land disposal of San Luis drain sediments, Panoche Water District, South Dos Palos, California

    SciTech Connect

    Zawislanski, Peter; Benson, Sally; TerBerg, Robert; Borglin, Sharon

    2002-07-01

    Lawrence Berkeley National Laboratory (LBNL), LFR Levine-Fricke (LFR), the U.S. Bureau of Reclamation (USBR) and the Panoche Water District, have completed a pilot-scale test of the viability of land application of selenium- (Se-) enriched San Luis Drain (SLD) sediments. The project was initiated in October 1998 by LBNL. LFR assumed the role of primary subcontractor on the project in July 2001. Substantial portions of this report, describing work performed prior to November 2000, were previously prepared by LBNL personnel. The data set, findings, and recommendations are herein updated with information collected since November 2000. Local land disposal is an attractive option due to its low cost and the proximity of large areas of available land. Two modes of disposal are being tested: (1) the application to a nearby SLD embankment, and (2) the application to and incorporation with nearby farm soils. The study of these options considers the key problems that may potentially arise from this approach. These include disturbance of SLD sediments during dredging, resulting in increased downstream Se concentrations; movement of the land-applied Se to groundwater; reduced productivity of farm crops; and Se uptake by wild and crop plants. This report describes field and laboratory activities carried out from 1998 through February 2002, and results of these investigations.

  1. 33 CFR 104.255 - Declaration of Security (DoS).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... engaging in a vessel-to-vessel activity, prior to the activity, the respective Masters, VSOs, or their... any passenger embarkation or disembarkation or cargo transfer operation, the respective Masters, VSOs... disembarkation or cargo transfer operation, the respective Masters, VSOs, or designated representatives must...

  2. 33 CFR 104.255 - Declaration of Security (DoS).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... engaging in a vessel-to-vessel activity, prior to the activity, the respective Masters, VSOs, or their... any passenger embarkation or disembarkation or cargo transfer operation, the respective Masters, VSOs... disembarkation or cargo transfer operation, the respective Masters, VSOs, or designated representatives must...

  3. 33 CFR 104.255 - Declaration of Security (DoS).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... engaging in a vessel-to-vessel activity, prior to the activity, the respective Masters, VSOs, or their... any passenger embarkation or disembarkation or cargo transfer operation, the respective Masters, VSOs... disembarkation or cargo transfer operation, the respective Masters, VSOs, or designated representatives must...

  4. 33 CFR 104.255 - Declaration of Security (DoS).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... engaging in a vessel-to-vessel activity, prior to the activity, the respective Masters, VSOs, or their... any passenger embarkation or disembarkation or cargo transfer operation, the respective Masters, VSOs... disembarkation or cargo transfer operation, the respective Masters, VSOs, or designated representatives must...

  5. 33 CFR 104.255 - Declaration of Security (DoS).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... engaging in a vessel-to-vessel activity, prior to the activity, the respective Masters, VSOs, or their... any passenger embarkation or disembarkation or cargo transfer operation, the respective Masters, VSOs... disembarkation or cargo transfer operation, the respective Masters, VSOs, or designated representatives must...

  6. Home before You Know It = De regres en casa en un dos por tres.

    ERIC Educational Resources Information Center

    Vida Health Communications, Inc., Cambridge, MA.

    The arrival of a newborn requires a great deal of adjustment. Intended for new and expectant parents, this booklet and companion video provide practical advice and hands-on demonstrations of the essentials of mother and baby care, from birth to the first visit to the pediatrician. The first part of the booklet, which comes in both English- and…

  7. Entre Dos Mundos/Between Two Worlds: Bicultural Development in Context

    ERIC Educational Resources Information Center

    Bacallao, Martica L.; Smokowski, Paul R.

    2009-01-01

    How do Mexican immigrant adolescents balance different, and often oppositional, cultural influences in the acculturation process? In this article, we explore how acculturating adolescents absorb cultural messages and go about creating their (multiple) identities. Guided by Alternation Theory, in-depth qualitative interviews were conducted with 12…

  8. The Politics of Hispanic Education. Un Paso pa'lante y dos pa'tras.

    ERIC Educational Resources Information Center

    Meier, Kenneth J.; Stewart, Joseph, Jr.

    This book presents an in-depth examination of 142 U.S. school districts (containing at least 5,000 students and 5 percent Hispanic enrollment) in order to understand Hispanic inequities in education and what can be done to correct these inequities. Chapter 1 presents political theory of educational policy. Chapter 2 presents an overview of the…

  9. Unidad: Las influencias culturales en el arte mexicana (Unit: Cultural Influences in Mexican Art). Dos semanas.

    ERIC Educational Resources Information Center

    Finere, Neal

    This two-week unit, appropriate for bilingual education settings as well as foreign language programs, deals with the three primary cultural influences found in Mexican contemporary art. The multisensory materials, pragmatic focus, and direct creative student involvement are designed to make it a microcosmic, real-life experience. The first part…

  10. Influencias africanas na lingua brasileira dos terreiros (African Influences in Brazilian Language of the Voodoo Rites).

    ERIC Educational Resources Information Center

    Megenney, William W.

    1991-01-01

    Discusses how determination of lexical items with Sub-Saharan origin in songs of voodoo rites of candomble and umbanda in southern and northeastern Brazil is complicated by factors like existence of phonological correspondence without accompanying semantic correspondence, difficulty of determining meaning of word in a given text, and high…

  11. Abundancias químicas de dos binarias de HgMn

    NASA Astrophysics Data System (ADS)

    Gonzalez, E. J.; González, J. F.; Collado, A. E.

    We present the results of the abundance analysis of two HgMn single-line binary systems: NGC 2287-106 and NGC 6025-14. The spectroscopic ob- servations have been carried out at the Complejo Astronómico el Leon-cito (CASLEO) with the REOSC spectrograph in cross-dispersion mode, cov- ering the spectral range 3800-5800 ≈. Compared to the Sun, NGC 6025-14 shows great overabundances of Hg, Mn, P, Ga and Xe, while Hg, Mn, Sr, Pt and Zr are overabundant in NGC 2287-106. FULL TEXT IN SPANISH

  12. The "Dos and Don'ts" of Writing a Journal Article

    ERIC Educational Resources Information Center

    Kekale, Tauno; de Weerd-Nederhof, Petra; Cervai, Sara; Borelli, Massimo

    2009-01-01

    Purpose: During work as reviewers and editors of journals authors are often faced the same types of problems in many articles. The purpose of this piece is to give some guidelines on typical problems that lead to rejection, and how to avoid these. Design/methodology/approach: The paper discusses journal article design and offers some methodology…

  13. Aspectos linguisticos dos emprestimos em portugues (Linguistic Aspects of Adaptation into Portuguese).

    ERIC Educational Resources Information Center

    Harmon, Ronald M.

    1994-01-01

    Examines the process through which modern Portuguese borrows from other languages, mainly French and English. Portuguese adapts these derivatives to conform to its own rules of phonology, morphology, and semantics. (four references) (Author/CK)

  14. A social media primer for professionals: digital dos and don'ts.

    PubMed

    Bernhardt, Jay M; Alber, Julia; Gold, Robert S

    2014-03-01

    Social media sites have become powerful and important tools for health education, promotion, and communication activities as they have dramatically grown in popularity. Social media sites also offer many features that can be used for professional development and advancement. When used wisely and prudently, social media sites and platforms offer great potential for professional development by building and cultivating professional networks, as well as sharing information to increase one's recognition and improve one's reputation. They also provide a medium for increasing one's knowledge and awareness of timely news and trends by following important organizations, opinion leaders, and influential professionals. When used unwisely and imprudently, there is the potential to delay, damage, or even destroy one's professional and personal life. In this commentary, we offer recommendations for using Facebook, LinkedIn, and Twitter for professional development and caution against online behaviors that may have negative professional consequences. In summary, we believe that the strengths and benefits of social media for professional advancement and development far outweigh the risks and encourage health promotion professionals to properly engage these powerful tools.

  15. Dos Puertorriquenos Visitan Puerto Rico (Two Puerto Ricans Visit Puerto Rico).

    ERIC Educational Resources Information Center

    Tuttle, Harry Grover

    These materials for Spanish instruction are based on the meeting and friendship of two Puerto Ricans arriving in Puerto Rico for visits to their hometowns, their discussions of Puerto Rican life, and a sightseeing tour of San Juan. Introductory passages to the visitors' dialogues are in English, and dialogues are in Spanish, with photographs,…

  16. A social media primer for professionals: digital dos and don'ts.

    PubMed

    Bernhardt, Jay M; Alber, Julia; Gold, Robert S

    2014-03-01

    Social media sites have become powerful and important tools for health education, promotion, and communication activities as they have dramatically grown in popularity. Social media sites also offer many features that can be used for professional development and advancement. When used wisely and prudently, social media sites and platforms offer great potential for professional development by building and cultivating professional networks, as well as sharing information to increase one's recognition and improve one's reputation. They also provide a medium for increasing one's knowledge and awareness of timely news and trends by following important organizations, opinion leaders, and influential professionals. When used unwisely and imprudently, there is the potential to delay, damage, or even destroy one's professional and personal life. In this commentary, we offer recommendations for using Facebook, LinkedIn, and Twitter for professional development and caution against online behaviors that may have negative professional consequences. In summary, we believe that the strengths and benefits of social media for professional advancement and development far outweigh the risks and encourage health promotion professionals to properly engage these powerful tools. PMID:24396119

  17. Buscando Su Voz en Dos Culturas = Finding Your Voice in Two Cultures.

    ERIC Educational Resources Information Center

    Cline, Zulmara

    1998-01-01

    An administrator/former teacher ponders difficulties of living in two cultures: a professional world that respects her degrees and credentials and a Latina world that questions pursuit of the "American dream." Although she used her American voice to coax a Latina student back to school, she sympathized with the mother's family-centered aspirations…

  18. The Puerto Ricans--Two Communities, One Culture. (Los Puertorriquenos--Dos Comunidades, Una Cultura.)

    ERIC Educational Resources Information Center

    Vivo, Paquita

    1980-01-01

    Puerto Rican roots stem from the ethnic mixture of Indians, Europeans, and Africans. This article describes the advent of each of the groups on the island, the historical and cultural impact each made, and the retention of heritage among Puerto Rican migrants to the U.S. (DS)

  19. Use of elephant grass for energy production in Campos dos Goytacazes-RJ, Brazil.

    PubMed

    Daher, R F; Souza, L B; Gravina, G A; Machado, J C; Ramos, H C C; Silva, V Q R; Menezes, B R S; Schneider, L S A; Oliveira, M L F; Gottardo, R D

    2014-01-01

    Elephant grass is a tropical forage plant widely distributed throughout Brazil. It was first exclusively used in the livestock sector as cattle feed. The grass is characterized by its high productivity and photosynthetic capacity and is considered as an alternative source of renewable energy. Here, we estimated the general combining ability of the parents and specific combining ability of the hybrids based on morpho-agronomic biomass-quality traits. The experiment was conducted in a randomized block design with 3 replicates. The diallel was composed of 16 hybrids and 2 groups of genitors. In the diallel analysis of variance, we observed a significant difference among treatments. A significant difference was observed among genitors for dry matter production (DMP). For the general combining ability of group 1, the traits leaf blade width, DMP, height, percentage of neutral detergent fiber, percentage of hemicellulose, percentage of lignin, percentage of acid detergent fiber, and percentage of cellulose were significant. For the estimates of general combining ability of DMP, parents Porto Rico 534-B, Vruckwona, Taiwan A-146, and Mercker S. E. A. were 0.4748, 3.2819, 1.1659, and 0.4317. The parents of Mercker S. E. A. and Porto Rico 534-B produced the highest percentage of detergent fiber and percentage of lignin with values of 0.1482 and 0.0856. Thus, parents Vruckwona, Porto Rico 534-B, and Taiwan A-146 are promising for integration into breeding programs. The best hybrid combinations for DMP were 1 x 5, 1 x 8, 2 x 6, 3 x 7, and 4 x 5. PMID:25526210

  20. Dos and Don'ts of Giving OTC Cough and Cold Medicines to Your Child

    MedlinePlus

    ... packages to keep track of important labels and expiration dates. Do store all medicines up and away, out ... prevent them from becoming less effective before their expiration dates. Don’ts Don’t give OTC cough and ...

  1. VizieR Online Data Catalog: The Solar Twin Planet Search. IV. (dos Santos+, 2016)

    NASA Astrophysics Data System (ADS)

    Dos Santos, L. A.; Melendez, J.; Do Nascimento, J.-D. Jr; Bedell, M.; Ramirez, I.; Bean, J. L.; Asplund, M.; Spina, L.; Dreizler, S.; Alves-Brito, A.; Casagrande, L.

    2016-07-01

    Ages, the measured projected rotational velocities (vsini) and stellar parameters of the 81 solar twins and the Sun. The ages of all solar twins and stellar parameters for HIP68468 were obtained by Tucci Maia et al. (2016A&A...590A..32T). Stellar parameters for the other solar twins were obtained by Ramirez et al. (2014A&A...572A..48R). The vsini were measured by line profile fitting using red spectra from HARPS (R=115000). Macroturbulence velocities were inferred from the scaling Eq. 2 in our study. (1 data file).

  2. Laryngeal complications by orotracheal intubation: Literature review.

    PubMed

    Mota, Luiz Alberto Alves; de Cavalho, Glauber Barbosa; Brito, Valeska Almeida

    2012-04-01

    Introdução: As lesões causadas pela intubação orotraqueal são comuns no nosso meio e amplamente relatadas pela literatura. Geralmente são causadas por acidentes na colocação do tubo ou consequência de sua permanência nas vias aéreas do paciente. Há diversos tipos de lesões laríngeas, causadas por múltiplos mecanismos.Objetivo: Verificar, na literatura, as principais causas de complicações laríngeas pós-intubação orotraqueal e seus mecanismos de lesão.Revisão de Literatura: As bases de dados pesquisadas foram LILACS, BIREME e SCIELO. Foram utilizados artigos, livros e teses, delimitando-se o período entre 1953 a 2009. As palavras-chaves utilizadas para a busca dos artigos foram: complicações, lesões, laringe, intubação, entubação, endotraqueal, orotraqueal, granulomas, estenose. Foram selecionadas 59 referências. Os critérios de inclusão utilizados para a escolha dos artigos foram os que mostraram os diversos tipos de lesões ocasionadas pela intubação orotraqueal e suas fisiopatologias.Considerações Finais: Esta revisão de literatura foi motivada pela observação na prática clínica de um grande número de sequelas laríngeas em pacientes submetidos à intubação orotraqueal. Diante disto é importante o conhecimento, pelos profissionais da área de saúde, dos tipos de complicações e de suas causas, com o intuito de evitá-las, adotando medidas de prevenção dessas lesões.

  3. [Progressive multifocal leukoencephalopathy associated to natalizumab: the importance of magnetic resonance imaging in its early diagnosis].

    PubMed

    Martí, Glòria; Río, Jordi; Rovira, Àlex; Auger, Cristina; Tintoré, Mar; Sastre-Garriga, Jaume; Vidal, Anka; Castilló, Joaquín; Montalban, Xavier

    2015-02-16

    Introduccion. El natalizumab es un farmaco utilizado en la esclerosis multiple (EM), cuyo principal efecto adverso es el desarrollo de una leucoencefalopatia multifocal progresiva (LMP). Como esta es potencialmente mortal o discapacitante, el tratamiento debe suspenderse inmediatamente ante su sospecha, teniendo en cuenta el posible desarrollo posterior de un sindrome de reconstitucion inmune o rebrote de la EM. Caso clinico. Se describe un caso de LMP, inicialmente asintomatico, en el contexto del tratamiento con natalizumab en una paciente con EM. Como factores de riesgo se determinaron titulos altos de anticuerpos contra el virus John Cunningham (VJC) y mas de dos años de tratamiento. La reaccion en cadena de la polimerasa para el VJC en el liquido cefalorraquideo resulto negativa en dos determinaciones. El periodo entre el diagnostico radiologico y el inicio de la clinica fue de dos meses. Durante el curso de la enfermedad, la paciente desarrollo un sindrome inflamatorio de reconstitucion inmune y rebrotes de su EM. Presento una buena respuesta tras el inicio de tratamiento con fingolimod, una vez estabilizada la LMP. Conclusion. Este caso ilustra la importancia de una estrecha vigilancia clinicorradiologica en pacientes con EM tratados con natalizumab, sobre todo cuando presentan factores de riesgo para el desarrollo de LMP, asi como su potencial incidencia en la supervivencia y estado funcional final.

  4. [Biomarkers of cervical carcinogenesis associated with genital human papillomavirus infection].

    PubMed

    Oliveira, Ana; Delgado, Candida; Verdasca, Nuno; Pista, Angela

    2013-01-01

    Introdução/Objetivos: A infeção persistente pelo Vírus do Papiloma Humano de alto risco (HPVar) é considerada como a causa necessária, embora não suficiente, para o desenvolvimento do cancro do colo do útero, sugerindo que outros fatores estarão envolvidos no processo de carcinogénese. Este estudo pretendeu avaliar indicadores de prognóstico da persistência da infeção por HPV, nomeadamente o estado físico e a carga viral dos HPV 16 e 18 e a superexpressão dos transcritos do RNAm dos HPV 16, 18, 31, 33 e 45, num grupo de mulheres com ou sem sintomatologia clínica e citopatológica. Material e Métodos: Foram estudadas 378 alíquotas de células epiteliais congeladas pertencentes a utentes dos centros de saúde do Serviço Nacional de Saúde e de clínicas privadas, referenciadas para teste HPV, entre Janeiro de 2007 e Dezembro de 2010. De acordo com o diagnóstico citopatológico, foram definidos cinco grupos: normal, ASCUS, LSIL, HSIL e carcinoma invasivo do colo do útero. Para a determinação do estado físico do DNA e da carga viral dos HPV 16 e 18 foi utilizada metodologia de PCR em tempo real, e para a superexpressão dos transcritos dos oncogenes E6 e E7 o sistema comercial NucliSENS EasyQ HPV®. Os indicadores foram analisados em associação com os tipos de lesão do colo do útero. Para a análise estatística foi utilizado o o programa informático SPSS versão 16.0 e o teste de Chi-Quadrado. Resultados: Os resultados mostraram ausência de associação estatisticamente significativa entre a gravidade da lesão e o estado físico do DNA dos HPV 16 e 18. A superexpressão dos transcritos do RNAm E6/E7 e a carga viral dos HPV 16 e 18 aumentaram significativamente em função do grau da lesão. Conclusões: Os resultados obtidos sugerem que a determinação do estado físico do DNA dos HPV 16 e 18, isoladamente, não constitui um indicador de prognóstico para o desenvolvimento e progressão das lesões. A superexpressão dos transcritos

  5. Impact of preoperative analytical values on post-operative mortality rate of intertrochanteric fractures.

    PubMed

    Borges, Ana; Torres, João; São Simão, Ricardo; Cabral, Abel Trigo; Pinto, Rui

    2014-01-01

    Introdução: A incidência das fraturas intertrocantéricas tem aumentado ao longo dos últimos anos, bem como todos os problemas a elas associados. É importante pesquisar possíveis formas de reduzir quer co-morbilidades, quer a mortalidade pós-operatória. Decidimos avaliar o impacto de alguns valores analíticos pré-operatórios na mortalidade pós-operatória de doentes com fractura intertrocantérica, com idade igual ou superior a 65 anos.Material e Métodos: De todas as fracturas intertrocantéricas admitidas entre Janeiro de 2007 e Maio 2012, 160 doentes foram incluídos no estudo. As variáveis estudadas foram idade, género, tempo de internamento, e dados analíticos, como hemoglobina, contagem de leucócitos e plaquetas, níveis de ureia e creatinina e concentração de sódio plasmática. Informação relativa à mortalidade foi obtida através do registo civil e, considerando um ponto de corte de seis meses após a cirurgia, os doentes foram divididos em dois grupos de acordo com a sua sobrevida. Os testes de Mann-Whitney e Chi-quadrado foram utilizados para estudar a associação entre as nossas variáveis e a sobrevida dos doentes.Resultados: A nossa população apresentava uma idade mediana de 82 anos de idade e uma maioria de mulheres (79,4%). Nos primeiros 6 meses após a cirurgia, 27 doentes dos iniciais 160 (16,1%) faleceram. A mortalidade estava relacionada com valores baixos de hemoglobina, elevados de plaquetas, elevados de creatinina e baixa concentração de sódio plasmático.Conclusão: A taxa de mortalidade pos-operatória da cirurgia da anca é elevada. Os nossos resultados podem ser utilizados parareduzir esta taxa, corrigindo valores analíticos pré-operatórios.

  6. The Dos and Don'ts of how to Build a Planet, Using the Moon as an Example

    NASA Technical Reports Server (NTRS)

    Jones, J. H.

    2006-01-01

    The bulk chemical compositions of planets may yield important clues concerning planetary origins. Failing that, bulk compositions are still important, in that they constrain calculation of planetary mineralogies and also constrain the petrogenesis of basaltic magmas. In the case of the Earth, there is little or no debate about the composition of the Earth's upper mantle. This is because our sample collections contain peridotitic xenoliths of that mantle. The most fertile of these are believed to have been little modified from their primary compositions. Using these samples and chondritic meteorites as a starting point, small perturbations on the compositions of existing samples allow useful reconstruction of the bulk silicate Earth (BSE). Elsewhere, I have argued that the next simplest case is the Eucrite Parent Body (EPB). Reconstructions based on Sc partitioning indicate that the EPB can be well approximated by a mixture of 20% eucrite and 80% equilibrium olivine. This leads to a parent body that is similar to CO (or devolatilized CM) chondrites. Partial melting experiments on CM chondrites confirm this model, because the residual solids in these experiments are dominated by olivine with minor pigonite [3]. The most difficult bodies to reconstruct are those that have undergone the most differentiation. Both the Moon and Mars may have passed through a magma ocean stage. In any event, lunar and martian basalts, unlike eucrites, were not derived from undifferentiated source regions. Reconstructions are primarily based on compositional trends within the basalts themselves with some critical assumptions: (i) Refractory lithophile elements (Ca, Al, REE, actinides) are presumed to be in chondritic relative abundances; and (ii) some major element ratio is believed to exist in a chondritic ratio (e.g., Mg/Si, Mg/Al). The most commonly used parameter is Mg/Si.

  7. Computer Aided Drafting Packages for Secondary Education. Edition 2. PC DOS Compatible Programs. A MicroSIFT Quarterly Report.

    ERIC Educational Resources Information Center

    Pollard, Jim

    This report reviews eight IBM-compatible software packages that are available to secondary schools to teach computer-aided drafting (CAD). Software packages to be considered were selected following reviews of CAD periodicals, computers in education periodicals, advertisements, and recommendations of teachers. The packages were then rated by…

  8. Cornell Produces a Video of Safety Dos and Don'ts for the YouTube Set

    ERIC Educational Resources Information Center

    Lipka, Sara

    2008-01-01

    Don't drink too much, download pirated files, light candles, or prop open doors. Warnings like those pervade the weighty work of admonition known as the student handbook. However, Allen J. Bova wonders, "Who ever reads that?" So Mr. Bova, director of risk management and insurance at Cornell University, tried to reach students with a video. This…

  9. GLOBAL CHANGE RESEARCH NEWS #9: ORD PROVIDES TECHNICAL SUPPORT TO EPA/OIA & DOS INITIATIVE IN EGYPT

    EPA Science Inventory

    This ninth edition reports on a workshop on global climate change that was held in Cairo, Egypt, on May 10-12, 1999. The workshop represented a successful partnership between EPA's Office of International Affairs, Office of Research and Development (ORD), Office of Air and Radiat...

  10. Buen Comienzo, Buen Futuro: El Bebe de Dos Meses (Healthy Start, Grow Smart: Your Two-Month-Old).

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    Distributed by the U.S. Departments of Agriculture, Education, and Health and Human Services, this Spanish-language pamphlet provides parents with information and advice about their infants in the second month of life. The pamphlet outlines typical infant behavior at 2 months of age, the need for regular visits to a physician, health insurance,…

  11. Hybrid Identity in Academic Writing: "Are There Two of Me?" (Identidad híbrida: "¿hay dos yo?")

    ERIC Educational Resources Information Center

    Crawford, Troy; Lengeling, Martha; Mora Pablo, Irasema; Heredia Ocampo, Rocío

    2014-01-01

    This paper explores the construction of identity in an academic learning environment in Central Mexico, and shows how identity may be linked to non-language factors such as emotions or family. These issues are associated with elements of hybrid identity. To analyze this we draw on language choice as a tool used for the construction of identity and…

  12. Cozinha: Um Lugar para a "bildung" dos Educadores (The Kitchen: A Place for the "bildung" of Educators).

    ERIC Educational Resources Information Center

    Damiano, Gilberto

    2000-01-01

    Uses a kitchen metaphor for philosophy of education, in dialogue with Augustine, Erasmus of Rotterdam, Brillat-Savarin, and others. Mixes and cooks ingredients in thinking: the centrality of the human being, corporeality, historicity, and transcendency; food as sign-symbol; eating-linguistic habits; educator-cook; space of the kitchen; sensuality,…

  13. (BARS) -- Bibliographic Retrieval System, Sandia Shock Compression (SSC) database Shock Physics Index (SPHINX). PC/DOS version 4.0

    SciTech Connect

    Herrmann, W.; Parker, T.J.; Mulholland, K.

    1993-09-01

    The Bibliographic Retrieval System (BARS) is a database management system specially designed to retrieve bibliographic references. Two databases are available, (i) the Sandia Shock Compression (SSC) database which contains over 5600 references to the literature related to stress waves in solids and their applications, and (ii) the Shock Physics Index (SPHINX) which includes over 6200 further references to stress waves in solids, material properties at intermediate and low rates, ballistic and hypervelocity impact, and explosive or shock fabrication methods. There is some overlap in the information in the two data bases.

  14. NGC 2849 y NGC 6134: dos cúmulos abiertos más para el proyecto BOCCE

    NASA Astrophysics Data System (ADS)

    Ahumada, A. V.; Bragaglia, A.; Cignoni, M.; Donati, P.; Tosi, M.; Marconi, G.

    The "Bologna Open Cluster Chemical Evolution" (BOCCE) project is a photometric and spectroscopic survey of Galactic open clusters (OCs), to be used as tracers of the properties and evolution of the Galactic disk. The main OCs parameters are derived in a precise and homogeneous way, and they will be used, for example, to determine the metallicity distribution in the Galactic disk and how it has evolved with time. We present here part of our last effort, concerning the photometric data obtained for NGC 2849 and NGC 6134. FULL TEXT IN SPANISH

  15. 76 FR 58074 - 30-Day Notice of Proposed Information Collection: DS-7001 and DS-7005, DOS-Sponsored Academic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ..., DS-7005. Respondents: Applicants for the Academic Exchange Program. Estimated Number of Respondents: 7160 (For DS-7001, 3842 estimated; for DS-7005, 3318 estimated). Estimated Number of Responses: 7160 (For DS-7001, 3842 estimated; for DS-7005, 3318 estimated). Average Hours per Response: 0.75....

  16. 76 FR 25733 - 60-Day Notice of Proposed Information Collection: DS-7001 and DS-7005, DOS-Sponsored Academic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    .... Respondents: Applicants for the Academic Exchange Program. Estimated Number of Respondents: 7160 (For DS-7001, 3842 estimated; for DS-7005, 3318 estimated). Estimated Number of Responses: 7160 (For DS-7001, 3842 estimated; for DS-7005, 3318 estimated). Average Hours per Response: 0.75. Total Estimated Burden:...

  17. A new generation of real-time DOS technology for mission-oriented system integration and operation

    NASA Technical Reports Server (NTRS)

    Jensen, E. Douglas

    1988-01-01

    Information is given on system integration and operation (SIO) requirements and a new generation of technical approaches for SIO. Real-time, distribution, survivability, and adaptability requirements and technical approaches are covered. An Alpha operating system program management overview is outlined.

  18. The DOS 1 neutron dosimetry experiment at the HB-4-A key 7 surveillance site on the HFIR pressure vessel

    SciTech Connect

    Farrell, K.; Kam, F.B.; Baldwin, C.A.

    1994-01-01

    A comprehensive neutron dosimetry experiment was made at one of the prime surveillance sites at the High Flux Isotope Reactor (HFIR) pressure vessel to aid radiation embrittlement studies of the vessel and to benchmark neutron transport calculations. The thermal neutron flux at the key 7, position 5 site was found, from measurements of radioactivation of four cobalt wires and four silver wires, to be 2.4 {times} 10{sup 12} n{center_dot}m{sup {minus}2}{center_dot}s{sup {minus}1}. The thermal flux derived from two helium accumulation monitors was 2.3 {times} 10{sup 12} n{center_dot}m{sup {minus}2}{center_dot}{sup {minus}1}. The thermal flux estimated by neutron transport calculations was 3.7 {times} 10{sup 12} n{center_dot}m{sup {minus}2}s{sup {minus}1}. The fast flux, >1 MeV, determined from two nickel activation wires, was 1.5 {times} 10{sup 12} n{center_dot}m{sup {minus}2}{center_dot}s{sup {minus}1}, in keeping with values obtained earlier from stainless steel surveillance monitors and with a computed value of 1.2 {times} 10{sup 13} n{center_dot}m{sup {minus}2}{center_dot}{sup {minus}1}. The fast fluxes given by two reaction-product-type monitors, neptunium-237 and beryllium, were 2.6 {times} 10{sup 13} n{center_dot}m{sup {minus}2}{center_dot}s {sup {minus}1} and 2.2 {times} 10{sup 13} n{center_dot}m{sup {minus}2}s{sup {minus}1}, respectively. Follow-up experiments indicate that these latter high values of fast flux are reproducible but are false; they are due to the creation of greater levels of reaction products by photonuclear events induced by an exceptionally high ratio of gamma flux to fast neutron flux at the vessel.

  19. [Deep brain stimulation: new frontier in the treatment of CNS disorders].

    PubMed

    Gonçalves Ferreira, Antonio

    2014-01-01

    Introdução: O autor faz uma revisão das indicações atuais da estimulação cerebral profunda, dos seus desenvolvimentos e resultados, dos alvos e técnicas utilizados, dos principais neurocirurgiões e centros médicos envolvidos.Material e Métodos: Esta revisão é baseada na experiência do grupo de Neurocirurgia Funcional do Hospital de Santa Maria (Centro Hospitalar Lisboa Norte) desde 1995 e na revisão bibliográfica dos artigos publicados sobre esta matéria desde 1980 indexados na PubMed.Resultados e Discussão: São apresentadas e discutidas as aplicações da estimulação cerebral profunda nos diferentes domínios das neurociências funcionais: Doenças do Movimento, incluindo doença de Parkinson, distonias e tremores, síndrome de Gilles de la Tourette, dor crónica, epilepsia e psicocirurgia nas múltiplas áreas que esta compreende: perturbação obsessiva-compulsiva, depressão grave refratária, comportamento disruptivo com agressividade intratável, deterioração da memória e demência, perturbações do comportamento alimentar (anorexia nervosa, obesidade mórbida) e toxicodependências refratárias (álcool, opioides, cocaína).Conclusões: Na maioria das situações clínicas referidas a estimulação cerebral profunda constitui um recurso terapêutico seguro e eficaz a ter em consideração quando as terapias habituais se mostram insuficientes; nos restantes casos há que reunir maior experiência até adotar o seu uso regular.

  20. [Response to treatment with interferon beta in patients with multiple sclerosis. Validation of the Rio Score].

    PubMed

    Rio, J; Rovira, A; Blanco, Y; Sainz, A; Perkal, H; Robles, R; Ramio-Torrenta, Ll; Diaz, R M; Arroyo, R; Urbaneja, P; Fernandez, O; Garcia-Merino, J A; Reyes, M P; Oreja-Guevara, C; Prieto, J M; Izquierdo, G; Olascoaga, J; Alvarez-Cermeno, J C; Simon, E; Pujal, B; Comabella, M; Montalban, X

    2016-08-16

    Introduccion. Se han propuesto diferentes criterios de respuesta al tratamiento con interferon beta, y el Rio Score es uno de los mas utilizados. El objetivo de este estudio fue validar la utilidad del Rio Score en una cohorte independiente. Pacientes y metodos. Estudio multicentrico, prospectivo y longitudinal de pacientes con esclerosis multiple remitente recurrente tratados con interferon beta. Los pacientes fueron clasificados basandose en la presencia de brotes, lesiones activas (nuevas en T2 o lesiones que captaban gadolinio) en la resonancia magnetica, incremento confirmado de la discapacidad o combinaciones de estas variables (brotes, incremento en la Expanded Disability Status Scale y lesiones activas) tras un año de tratamiento. Se utilizo un analisis de regresion con el fin de identificar las variables de prediccion de respuesta despues de un seguimiento de tres años. Resultados. Se incluyo a 249 pacientes con esclerosis multiple remitente recurrente. El modelo logistico confirmo que la presencia de dos (odds ratio = 6,6; IC 95% = 2,7-16,1; p < 0,0001) o tres (odds ratio = 8,5; IC 95% = 1,6-46; p < 0,01) variables positivas durante el primer año de tratamiento conferia un riesgo significativo de actividad (brotes o progresion) en los siguientes dos años. Conclusiones. Se confirma, en una cohorte independiente, la utilidad del Rio Score para identificar a pacientes con un mayor riesgo de desarrollar actividad clinica o progresion de la discapacidad durante el tratamiento con interferon beta.

  1. Bioavailability of iron measurement in two nutrients multiple solutions by in vitro and in vivo;a comparative methodology between methods.

    PubMed

    Bueno, Luciana; Pizzo, Juliana C; Freitas, Osvaldo; Barbosa Júnior, Fernando; dos Santos, José Ernesto; Marchini, Julio Sergio; Dutra-de-Oliveira, José Eduardo

    2013-01-01

    Objetivos: La biodisponibilidad de hierro presente en una formulación nutricional puede ser evaluada por in vitro y in vivo, ya que proporcionan para un estudio de línea cohesiva y proporcionado en la literatura. El objetivo de estudio fue evaluar la biodisponibilidad de hierro con in vitro y in vivo, dirigida a un análisis comparativo de dos formulaciones de suplementos nutricionales (A y B). Métodos: Fueron utilizados dos métodos descritos en la literatura que para evaluar la biodiponibilidad de hierro. Uno que es la simulación de digestión humana y otro por los niveles de hierro sérico después de la ingestión de la formulación en los seres humanos. Resultados: Los resultados obtenidos por la simulación in vitro de la digestión del tracto gastrointestinal humano fueron 0,70 ± 0,02 y 0,80 dialisibilidad 0,01% de hierro, respectivamente, para las formulaciones A y B. Los estudios in vivo, segú n se mide por las curvas de hierro en suero en seres humanos después de la ingestión de las formulaciones mostró coeficiente de variación Δ < 0, lo que indica que había una baja absorción de hierro. La biodisponibilidad de hierro a los dos multi-nutrientes soluciones fueron obtenidos por in vitro y in vivo mostraron que había una comparación de las metodologías utilizadas en soluciones acuosas de muchos nutrientes.

  2. [Retrospective analysis of the effect of a vagus nerve stimulator implanted in paediatric patients with refractory epilepsy].

    PubMed

    Fuentes-Pita, P; Gomez-Lado, C; Dacruz, D; Eiris-Punal, J; Prieto-Gonzalez, A; Castro-Gago, M

    2016-07-01

    Introduccion. El estimulador vagal es una alternativa terapeutica en los pacientes con epilepsia refractaria al tratamiento con farmacos antiepilepticos que no son candidatos a cirugia de reseccion. Objetivo. Analizar la eficacia del estimulador vagal en los pacientes pediatricos de nuestro centro. Pacientes y metodos. Conjunto de 13 pacientes implantados entre los años 2008 y 2013. Se registro la frecuencia de crisis previa a la implantacion, al año, a los dos años y al final del seguimiento. Asimismo, se recogio el numero de farmacos antiepilepticos utilizados, de forma cualitativa la mejoria conductual y el cambio en la intensidad de las crisis, asi como la aparicion de efectos secundarios y la retirada o no del dispositivo. Resultados. Al año, a los dos años y al final del seguimiento se habia producido una reduccion en el numero de crisis del 61%, 66,7% y 69%, respectivamente, y uno de los pacientes se encontro libre de crisis a los dos años. Al final del seguimiento, un 23% de los que habian disminuido sus crisis habia experimentado una reduccion superior al 90%. De forma independiente al efecto sobre el numero de crisis, el 77% de los pacientes presento una mejoria en la intensidad y duracion de las crisis, y ese mismo porcentaje mostro una mejoria conductual. Los efectos secundarios aparecieron en un 30,7% de los pacientes y fueron de intensidad leve. Conclusiones. A pesar del pequeño tamaño de la muestra, nuestros resultados indican que el estimulador vagal tiene una eficacia relevante en la poblacion pediatrica farmacorresistente, tanto sobre la frecuencia e intensidad de las crisis como sobre la conducta.

  3. [Prevalence of undernutrition in hospital patients with unbalanced heart failure; subjective global assessment like prognosis sign].

    PubMed

    Guerra-Sánchez, Luis; Martinez-Rincón, Carmen; Fresno-Flores, Mar

    2015-04-01

    Introducción: Existe una gran variabilidad en los estudios sobre la prevalencia de malnutrición en pacientes con insuficiencia cardiaca crónica. La proporción de pacientes desnutridos depende del método de valoración utilizado y del momento en que se realice. Se ha descrito la relación entre desnutrición y aumento de las complicaciones, de la estancia hospitalaria, de la mortalidad y de reingreso hospitalario. Por lo que merece la pena señalar y tratar a estos pacientes. Objetivos: El objetivo fue aproximarnos a la prevalencia de la desnutrición, en los pacientes con insuficiencia cardiaca crónica ingresados por descompensación, en nuestro medio y analizar cuál de los dos métodos de valoración nutricional utilizados, era mejor predictor de mortalidad. Métodos: Estudio observacional, transversal, en el que se evaluaron mediante la Valoración Subjetiva Global y Mini Nutritional Assesment , el estado nutricional de 377 pacientes ingresados en un hospital terciario de alta complejidad con diagnósticos compatibles con descompensación de insuficiencia cardiaca crónica. Resultados: La edad media fue de 75±10. El 51,5%(n=194) fueron hombres. Según la Valoración Subjetiva Global, el 50,7% (45,6%-55,7%) estaban normonutridos, el 41,9% (37,0%-46,9%) presentaban riesgo o sospecha de desnutrición y el 7,4% (5,2%-10,5%) presentaban desnutrición franca. Conclusiones: La prevalencia de desnutrición de los pacientes hospitalizados por descompensación de Insuficiencia Cardiaca crónica en nuestro ámbito es alta. La Valoración Subjetiva Global es un buen predictor de la mortalidad.

  4. [MAST and AUDIT. Evaluation of psychometric characteristics in patients with alcohol dependence].

    PubMed

    Fonte, Aníbal; Mota-Cardoso, Rui

    2013-01-01

    Introdução/Objectivo: Avaliar a correlação entre a pontuação no MAST e no AUDIT em doentes internados para desintoxicaçãopor dependência de álcool e analisar a possibilidade destas pontuações refletirem a intensidade da gravidade da dependência e dos problemas relacionados com o uso do álcool.Material e Métodos: Estudo correlacional. Doentes internados pela primeira vez, para tratamento por dependência de álcool. Além de uma entrevista estruturada, do MAST e do AUDIT, foi utilizado o SADD para avaliação do grau de dependência do álcool e o APQ para os problemas relacionados com o consumo de álcool.Resultados: A consistência interna (α de Cronbach) do MAST foi 0,77 e a do AUDIT foi 0,73. A correlação entre os dois instrumentos foi moderada (R = 0,497, p < 0,001). Ambos apresentam correlação moderada e significativa (p < 0,001) com o SADD e o APQ. O conjunto de itens do AUDIT dirigidos para a dependência têm maior correlação com o SADD do que com o APQ, sucedendo o inverso com o conjunto de itens pertencentes à dimensão problemas/consequências adversas. Os dois instrumentos apresentam correlação baixa com o volume de álcool consumido avaliado em g/d.Conclusão: Tanto o MAST como o AUDIT apresentam uma pontuação total que reflete a gravidade da dependência e das perturbações induzidas pelo álcool. Em populações clínicas estes instrumentos podem ser utilizados como variável contínua, para registo quantitativo da magnitude dos problemas. O AUDIT, relativamente ao MAST, tem a vantagem de apresentar um número menor de itens, ser mais fácil de responder e de cotar. O AUDIT tem ainda a vantagem de apresentar conjuntos de itens pertencentes a três dimensões (quantidade/frequência, dependência, problemas/consequências adversas) que podem ser analisados separadamente permitindo uma caracterização mais especificação das situações em estudo.

  5. Uso de modelos mecânicos em curso informal de astronomia para deficientes visuais. Resgate de uma experiência

    NASA Astrophysics Data System (ADS)

    Tavares, E. T., Jr.; Klafke, J. C.

    2003-08-01

    O presente trabalho propõe-se a resgatar uma experiência que teve lugar no Planetário de São Paulo nos anos 60. Em 1962, o Sr. Acácio, então com 37 anos, deficiente visual desde os 27, passou a assistir às aulas ministradas pelo Prof. Aristóteles Orsini aos integrantes do corpo de servidores do Planetário. O Sr. Acácio era o único deficiente da turma e, embora possuísse conhecimentos básicos e relativamente avançados de matemática, enfrentava dificuldades na compreensão e acompanhamento da exposição, como também em estudos posteriores. Com o intuito de auxiliá-lo na superação desses problemas, o Prof. Orsini solicitou a construção de modelos mecânicos que, através do sentido do tato, permitissem o acompanhamento das aulas e a transposição do modelo para o "constructo" mental. Essa prática mostrou-se tão eficaz que facilitou sobejamente o aprendizado da matéria pelo sujeito. O Sr. Acácio passou a integrar o corpo de professores do Planetário/Escola Municipal de Astrofísica, tendo ficado responsável pelo curso de "Introdução à Astronomia" por vários anos. Além disso, a experiência foi tão bem sucedida que alguns dos modelos tiveram seus elementos constitutivos pintados diferencialmente para serem utilizados em cursos regulares do Planetário, tornando-se parte integrante do conjunto de recursos didáticos da instituição. É pensando nessa eficácia, tanto em seu objetivo original permitir o aprendizado de um deficiente visual quanto no subsidiário recurso didático sistemático da instituição que decidimos resgatar essa experiência. Estribados nela, acreditamos ser extremamente produtivo, em termos educacionais, o aperfeiçoamento dos modelos originais, agora resgatados e restaurados, e a criação de outros que pudessem ser utilizados no ensino dessa ciência a deficientes visuais.

  6. ASSESSMENT OF GOOD PRACTICES IN HOSPITAL FOOD SERVICE BY COMPARING EVALUATION TOOLS.

    PubMed

    Macedo Gonçalves, Juliana; Lameiro Rodrigues, Kelly; Santiago Almeida, Ângela Teresinha; Pereira, Giselda Maria; Duarte Buchweitz, Márcia Rúbia

    2015-10-01

    Introducción: por ser un adyuvante al tratamiento médico, la alimentación hospitalaria debe ser producida en adecuadas condiciones higiénicas y sanitarias, considerando qué enfermedades transmitidas por los alimentos afectan con mayor severidad a pacientes hospitalizados e inmunodeprimidos. Objetivos: evaluar la adopción de buenas prácticas en los servicios de alimentación hospitalarios, comparando instrumentos de evaluación. Métodos: la evaluación de las buenas prácticas fue realizada utilizando una lista de verificación conforme la Resolución de Directora Colegiada – RDC n.º 216 de la Agencia Nacional de Vigilancia Sanitaria. Para la interpretación de los ítems listados fueron utilizados los parámetros de la RDC n.º 216 y de la Asociación Brasileña de Empresas de Comidas Colectivas (ABERC). Se aplicó el test exacto de Ficher para analizar si existían diferencias estadísticamente significativas y también fue realizado un análisis de agrupamiento de los datos per el método Unweighted Pair-group using Arithmetic Averages y un estudio de la correlación entre las matrices de disimilitud, objetivando verificar la concordancia entre los dos métodos de diagnóstico. Resultados y discusión: las buenas prácticas fueron clasificadas con valores medios totales superiores al 75% de adecuación, en los dos instrumentos utilizados. Se observaron diferencias estadísticamente significativas entre los servicios y la alimentación evaluados por el instrumento de la ABERC. Los servicios de alimentación hospitalarios, de modo general, presentaron condiciones de buenas prácticas aceptables. Conclusión: la comparación de los instrumentos de interpretación basados en la RDC n.º 216 y ABERC mostró resultados semejantes en ambas clasificaciones.

  7. A software oscilloscope for DOS computers with an integrated remote control for a video tape recorder. The assignment of acoustic events to behavioural observations.

    PubMed

    Höller, P

    1995-12-01

    With only a little knowledge of programming IBM compatible computers in Basic, it is possible to create a digital software oscilloscope with sampling rates up to 17 kHz (depending on the CPU- and bus-speed). The only additional hardware requirement is a common sound card compatible with the Soundblaster. The system presented in this paper is built to analyse the direction a flying bat is facing during sound emission. For this reason the system works with some additional hardware devices, in order to monitor video sequences at the computer screen, overlaid by an online oscillogram. Using an RS232-interface for a Panasonic video tape recorder both the oscillogram and the video tape recorder can be controlled simultaneously and moreover be analysed frame by frame. Not only acoustical events, but also APs, myograms, EEGs and other physiological data can be digitized and analysed in combination with the behavioural data of an experimental subject.

  8. Environmental factors affecting the distribution of land snails in the Atlantic Rain Forest of Ilha Grande, Angra dos Reis, RJ, Brazil.

    PubMed

    Nunes, G K M; Santos, S B

    2012-02-01

    The distribution and abundance of terrestrial molluscs are affected by environmental factors, but data are lacking for Brazilian land snails. The aim of this study was to understand the relationship between measured environmental factors and the land-snail species composition of two hillsides covered with Atlantic Rain Forest on Ilha Grande. On each hillside, five plots located at 100 m intervals between 100 to 500 m asl were chosen. Each plot was sampled by carrying out timed searches and collecting and sorting litter samples from ten quadrats of 25 × 75 cm. A range of environmental data was measured for each of the quadrats in a plot. A Cluster Analysis was carried out for the richness and abundance data. The environmental variables were analysed using a Pearson Correlation Matrix and Discriminant Analysis. Our results show that the two mountains are similar in species richness, but species composition and abundance are different, probably reflecting observed differences in environmental conditions. The environmental factors associated with compositional variation between the two mountains were: atmospheric temperature, soil temperature, litter depth, and relative air humidity. Distinct luminosity and canopy closure conditions were related to the composition of the land-snail community of one hillside. PMID:22437388

  9. Yo Ciudadano: Un Curriculo de Experiencias para Educacion Civica. Nivel: Dos (Citizen Me: An Experiential Curriculum for Citizenship Education. Level: Two).

    ERIC Educational Resources Information Center

    Lantz, Jean

    Integrating concepts of basic citizenship education with community involvement, this experiential curriculum provides a means for developing decision making and critical thinking skills within the existing second grade social studies curriculum. The 10 lessons, translated into Spanish, cover the following concepts: friendly, unfriendly and…

  10. Neodymium, strontium and chromium isotopic studies of the LEW86010 and Angra dos Reis meteorites and the chronology of the angrite parent body

    NASA Technical Reports Server (NTRS)

    Nyquist, L. E.; Bansal, B.; Wiesmann, H.; Shih, C.-Y.

    1994-01-01

    Neodymium, stontium, and chromium isotopic studies of the LEW86010 angrite established its absolute age and the formation interval between its crystallization and condensation of Allende CAIs from the solar nebula. Pyroxene and phosphate were found to contain approximately 8% of its Sm and Nd inventory. A conventional Sm-147-Nd-143 isochron yielded an age of 4.53 +/- 0.04 Ga (2 sigma and Epsilon(sub Nd sup 143)) = 0.45 +/- 1.1. An Sm-146-Nd-142 isochron gives initial Sm-146/Sm-144 = 0.0076 +/- 0.0009 and Epsilon (sub Nd sup 142) = -2.5 +/- 0.4. The Rb-Sr analyses give initial Sr-87/Sr-86 Iota(sub Sr sup 87) = 0.698972 +/- 8 and 0.698970 +/- 18 for LEW and ADOR, respectively, relative to Sr-87/Sr-86 = 0.71025 for NBS987. The difference, Delta Iota(sub Sr Sup 87), between Iota (sub sr sup 87) for the angrites and literature values for Allende CAIs, corresponds to approximately Ma of growth in a solar nebula with a CI chondrite value of Rb-87/Sr-86 = 0.91, or approximately 5 Ma in a nebula with solar photospheric Rb-87/Sr-86 = 1.51. Excess Cr-53 from extinct Mn-53(t(sub 1/2) = 3.7 Ma)in LEW86010 corresponds to initial Mn-53/Mn-55 = 4.4 +/- 1.0 x 10(exp -5) for the inclusions as previously reported by the Paris group (Birck and Allegre, 1988). The Sm-146/Sm-144 value found for LEW86010 corresponds to solar system initial (Sm-146/Sm-144) = 0.0080 +/- 0.0009 for crystallization 8 Ma after Allende, the difference between Pb-Pb ages of angrites and Allende, or 0.0086 +/- 0.0009 for crystallation 18 Ma after Allende, using the Mn-Cr formation interval. The isotopic data are discussed in the context of a model in which an undifferentiated 'chondritic' parent body formed from the solar nebula approximately Ma after Allende CAIs and subsequently underwent differentiation accompanied by loss of volatiles. Parent bodies with Rb/Sr similar to that of CI, CM, or CO chondrites could satisfy the Cr and Sr isotopic systematics. If the angrite parent body had Rb/Sr similar to that of CV meteorites, it would have to form slightly later, approximately 2.6 Ma after the CAIs, to satisfy the Sr and CR isotopic systematics.

  11. Adolescentes que no habrían fumado pueden ser atraídos por los cigarrillos electrónicos

    Cancer.gov

    Artículo del blog Temas y relatos sobre un estudio reciente que sugiere que los adolescentes están usando cigarrillos electrónicos no solo como sustituto de cigarrillos convencionales sino cigarrillos electrónicos están atrayendo nuevos usuarios de tabaco

  12. A Educacao dos Portadores de Necessidades Especiais no Brasil no Periodo de 1910 a 1949 (Education of Those with Special Needs in Brazil from 1920 to 1949).

    ERIC Educational Resources Information Center

    Marques, Carlos Alberto; Santiago, Mylene Cristina; de Moura, Simone Moreira

    2000-01-01

    Examines education given to those with special needs in Brazil from 1910-1949. Shows the dichotomy of meanings in which the education of special needs persons during that period, besides being marked by concepts related to the exclusion paradigm, already indicated signs of respect for diversity and civil rights. (BT)

  13. Sanchez and Metz Elementary Schools: Dos Idiomas, Un Mundo. Dual Language Project. Title VII First-Year Evaluation Report, 1995-96.

    ERIC Educational Resources Information Center

    Ernest, Harishini M.; Gonzalez, Rosa Maria

    The first-year evaluation of a two-way Spanish/English bilingual education program at two Austin (Texas) elementary schools is presented. The developmental program has as its objectives the development of students' oral proficiency in Spanish and English, development of grade-level appropriate literacy in both languages, increase in academic…

  14. El Proyecto Cunningham: Dos Idiomas; Muchos Paises, 1995-96 (The Cunningham Project: Two Languages, Many Countries, 1995-96). Research Report on Educational Grants.

    ERIC Educational Resources Information Center

    Houston Independent School District, TX. Dept. of Research and Evaluation.

    This report presents an evaluation of a two-way bilingual program in English and Spanish at the Cunningham Elementary School (Texas). The program was designed to extend and expand educational reform by shifting the instructional program at the school over the 5-year time span from a transitional bilingual program to a two-way bilingual, or dual…

  15. Dos Idiomas, Un Mundo Dual Language Project Title VII Third-Year Evaluation Report, 1997-98. Publication Number 97.21.

    ERIC Educational Resources Information Center

    Liberty, Paul; Gonzalez, Rosa Maria

    An evaluation was conducted of the third year of a 5-year comprehensive bilingual education grant funded by Title VII of the Improving America's Schools Act of 1994. The grant funds a program of developmental bilingual education at two elementary schools in the Austin Independent School District (Texas). More than 25% of the students at each…

  16. En Busqueda de la Escuela del Siglo XXI: Dos Experiencias de Autoaprendizaje (In Search of the 21st Century School: Two Self-Learning Experiences).

    ERIC Educational Resources Information Center

    Schiefelbein, Ernesto; And Others

    This book is a contribution to the dialogue that is maintained today around the problems of education. The book contains four parts: (1) "In Search of the 21st Century School. Can the Colombian New School (EN) Show Us the Way?"; (2) "Experimentation with Self-Learning Materials in Two Schools in Conchali (Chile)"; (3) "Self-Learning Module for the…

  17. La investigacion sobre la calidad de los programas para ninos de hasta dos anos de edad (Research on Quality in Infant-Toddler Programs). ERIC Digest.

    ERIC Educational Resources Information Center

    Honig, Alice Sterling

    Concern about the quality of infant-toddler care programs has grown recently in response to two factors. The first is the need of employed parents for such care, and the second is research emphasizing the importance of brain development in the early years. This Spanish-language Digest introduces some of the many issues related to the quality of…

  18. 32 CFR Appendix C to Part 197 - Procedures for the Department of State (DoS) Foreign Relations of the United States (FRUS) Series

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Foreign Relations of the United States (FRUS) Series C Appendix C to Part 197 National Defense Department... RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt. 197, App. C Appendix C to Part... such non-DoD Agency classified information expected to be interfiled with the requested OSD records....

  19. How Do You Say "Twos" in Spanish, if "Two" Is "Dos"? Language as Means and Object in a Bilingual Kindergarten Classroom

    ERIC Educational Resources Information Center

    Mulvihill, Naomi

    2014-01-01

    In this essay Naomi Mulvihill uses vignettes from her bilingual kindergarten classroom to explore the dynamic processes by which young children make sense of language, focusing on instances in which she asks her students to compare texts presented in English and Spanish. Using Piaget's concept of disequilibrium as a guiding framework,…

  20. Análise da aplicação e dos resultados do modelo OPM3® para a área da saúde

    PubMed Central

    Augusto dos Santos, Luis; de Fátima Marin, Heimar

    2015-01-01

    Esta pesquisa procurou analisar se um modelo de questionário criado por uma comunidade internacional de gerenciamento de projetos e se é aplicavél a organizações voltadas a área de saúde. O modelo OPM3® (Organizational Project Management Maturity Model) foi criado para que organizações de qualquer área ou porte pudessem identificar a presença, ou ausência, de boas práticas de gerenciamento. O objetivo da aplicação desse modelo é avaliar sempre a organização e não o entrevistado. No presente artigo, são apresentados os resultados da aplicação desse modelo em uma organização que possuía produtos e serviços de tecnologia da informação aplicados à área de saúde. Este estudo verificou que o modelo é aplicável de forma rápida e que a organização analisada possuía um número expressivo de boas práticas. PMID:26924862

  1. [Primary and secondary outcomes in oncology clinical trials: definitions and uses].

    PubMed

    Vaz-Carneiro, António; Luz, Ricardo; Borges, Margarida; Costa, João

    2014-01-01

    Introdução: A prova de eficácia de uma intervenção terapêutica em oncologia consegue-se através de ensaios clínicos rigorosamente conduzidos. Um dos factores metodológicos mais importantes é a selecção de indicadores clínicos de eficácia (outcomes), necessários ao cálculo das chamadas medidas de associação que permitem a definição de eficácia terapêutica. Material e Métodos: Foi feita uma revisão narrativa baseada em alguns dos documentos de agências reguladoras internacionais, assim como documentos de consenso entre as sociedades científicas oncológicas, procurando listar e avaliar criticamente cada um dos indicadores utilizados em ensaios clínicos oncológicos. Resultados: Identificaram-se como indicadores mais importantes a sobrevivência global, a sobrevivência livre de progressão/sobrevivência livre de doença, a toxicidade/qualidade de vida e taxa objectiva de resposta tumoral. Discussão: A selecção do outcome primário deve basear-se no conceito de eficácia terapêutica, mas também na toxicidade relativa da terapêutica experimental, na sobrevivência esperada após progressão da doença, na existência de fármacos alternativos já estudados com indicações idênticas e até a prevalência da patologia em causa. Conclusão: A selecção de indicadores em ensaios clínicos oncológicos reveste-se de especial importância e a sua selecção deve ser bem fundamentada, dependendo da doença, dos doentes e do fármaco em estudo.

  2. [Acute respiratory distress syndrome: case series, two years at an intensive care unit].

    PubMed

    Taborda, Lúcia; Barros, Filipa; Fonseca, Vitor; Irimia, Manuel; Carvalho, Ramiro; Diogo, Cláudia; Ramos, Armindo

    2014-01-01

    Introdução: A Síndrome de Dificuldade Respiratória Aguda apresenta incidência e mortalidade significativas em Cuidados Intensivos, justificando estudos adicionais, nomeadamente para definição de novas abordagens terapêuticas. Os autores propuseram-se caracterizaros casos duma Unidade de Cuidados Intensivos em dois anos.Material e Métodos: Procedeu-se a um estudo observacional retrospectivo dos casos admitidos numa Unidade de Cuidados Intensivos, cumprindo os critérios diagnósticos da American-European Consensus Conference on ARDS, tendo sido excluídos os não ventilados invasivamente. Pesquisados e submetidos a tratamento estatístico: dados demográficos, etiologia do Síndrome de Dificuldade Respiratória Aguda, comorbilidades, Índices de Gravidade, PaO2/FiO2, modalidades e parâmetros ventilatórios, compliance pulmonar, dias de ventilação mecânica invasiva, corticoterapia, terapêuticas de resgate, complicações, duração do internamento, óbitos.Resultados: Obtiveram-se 40 doentes, com uma mediana de 72,5 anos (amplitude interquartil 22) e um ratio feminino:masculino ≈1:1,86. Cinquenta e cinco por cento dos Síndrome de Dificuldade Respiratória Aguda tiveram etiologia pulmonar. A média do PaO2/ FiO2 mínimo foi 88mm Hg (IC 95%: 78,5-97,6). A média da PEEP máxima aplicada foi 12,4 cmH2O (Desvio Padrão 4,12) e a médiado Volume Corrente máximo utilizado foi 8,2 mL/Kg peso ideal (IC 95%: 7,7-8,6). A mediana dos dias de ventilação mecânica invasiva foi 10. Em 47,5% dos doentes foram administrados corticóides. Em 52,5% foi executado recrutamento alveolar. A complicação mais frequente foi a Pneumonia Associada a Ventilação (20%). A mediana da duração do internamento foi 10,7 dias (amplitude interquartil10,85). Faleceram 60% dos doentes. A probabilidade de outcome favorável ‘não óbito na Unidade de Cuidados Intensivos’ foi 4,4x superior nos doentes sob corticoterapia e 11x superior nos doentes com idade < 65 anos

  3. [Status epilepticus in paediatrics: a retrospective study and review of the literature].

    PubMed

    Moreno-Medinilla, Esther E; Negrillo-Ruano, Rocío; Calvo-Medina, Rocío; Mora-Ramírez, M Dolores; Martínez-Antón, Jacinto L

    2015-05-01

    Introduccion. El estado epileptico (EE) es la emergencia neurologica mas frecuente en pediatria. Dada la posibilidad de secuelas neurologicas y mortalidad asociadas, requiere un tratamiento agresivo precoz. Pacientes y metodos. Estudio descriptivo retrospectivo a traves de la revision de historias clinicas de pacientes ingresados en nuestro hospital entre 2010-2013 con diagnostico de EE. El objetivo fue describir las caracteristicas epidemiologicas y el manejo de estos pacientes, asi como revisar la bibliografia disponible sobre este tema. Resultados. Hemos recogido 39 pacientes (25 varones) y 51 episodios de EE. Edad media: 4,8 años. Tenian enfermedad de base 22 pacientes. Dieciocho eran epilepticos conocidos y cinco tuvieron un EE previo. De los 51 episodios de EE, 33 fueron sintomaticos, 15 febriles y tres criptogenicos. Los tipos de EE fueron: 25 parciales (de ellos, 16 complejos) y 26 generalizados. El tratamiento de primera eleccion fue benzodiacepinas en 47 pacientes (40, diacepam), fenitoina en tres y acido valproico en uno. Veintisiete pacientes precisaron farmacos de segunda linea: 16, acido valproico; ocho, fenitoina; dos, fenobarbital; y uno, levetiracetam. Diez pacientes precisaron farmacos de tercera linea para la induccion del coma: el midazolam fue el mas utilizado en nuestro centro, seguido del tiopental y el propofol. Dos EE superrefractarios requirieron inmunoglobulinas y corticoides sistemicos por presentarse en el curso de encefalitis autoinmunes. Conclusiones. Debe plantearse el esquema terapeutico del EE desde el inicio de cualquier crisis convulsiva. El tratamiento es escalonado, con benzodiacepinas en la primera etapa, antiepilepticos de amplio espectro y disponibilidad intravenosa en la segunda (acido valproico, levetiracetam en el EE generalizado y fenitoina en el EE focal), mientras que el tercer nivel varia en funcion de la experiencia de cada equipo.

  4. Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center Experience.

    PubMed

    Dantas Brito, Margarida; Campilho, Fernando; Branca, Rosa; Vaz, Carlos; Roncon, Susana; Campos, António

    2016-03-01

    Introdução: O linfoma não Hodgkin difuso de grandes células B pode ser curado em 60% - 70% dos doentes. O transplante autológo de progenitores hematopoiéticos é o tratamento de intenção curativa standard à recidiva. Este tratamento intensivo após primeira remissão num grupo selecionado de doentes de alto risco é controverso e fez parte da estratégia do nosso Serviço durante alguns anos. Material e Métodos: Estudo retrospectivo, consulta do processo clínico. Resultados: Este estudo analisa o outcome de 113 doentes transplantados entre 1992 e 2012. Formaram-se quatro grupos com base no status pré-transplante: a) primeira remissão completa após 1 ciclo de quimioterapia (n = 64); b) segunda remissão completa após ≥ duas linhas de quimioterapia (n = 15); c) segunda remissão completa (n = 15); d) doença mais avançada (n = 19). O protocolo de quimioterapia de primeira linha mais utilizado foi R-CHOP (n = 71) e CHOP (n = 28). O seguimento mediano foi de 34 meses (1 - 221). Aos cinco anos a sobrevivência global foi de 73% (± 5) e a sobrevivência livre de progressão 75% (± 5). Conclusão: A imunoquimioterapia convencional seguida de transplante autólogo é uma opção segura e eficaz no tratamento de casos selecionados de linfoma difuso de grandes células B. Na nossa casuística cerca de 70% dos doentes de alto risco atingiram remissões duráveis com esta estratégia terapêutica.

  5. [Neuropsychological rehabilitation in wartime].

    PubMed

    García-Molina, Alberto; Roig-Rovira, Teresa

    2013-11-16

    Introduccion. El descenso de la mortalidad por daño cerebral durante la Primera Guerra Mundial ocasionara un elevado numero de veteranos con secuelas neurologicas o neuropsicologicas. Esta situacion, desconocida hasta entonces, requerira el desarrollo de nuevos abordajes terapeuticos que les ayuden a alcanzar unas cotas de autonomia aceptables. Desarrollo. Este articulo revisa la relacion existente entre la rehabilitacion neuropsicologica y la guerra y describe las aportaciones hechas por diferentes profesionales de este ambito en los dos grandes conflictos belicos del siglo XX. La Primera Guerra Mundial marcara el inicio de la rehabilitacion neuropsicologica tal y como la conocemos actualmente; en ese periodo destacaran las contribuciones realizadas por Goldstein y Poppelreuter en Alemania o Franz en Estados Unidos. La Segunda Guerra Mundial supondra la consolidacion de esta disciplina sanitaria; los principales referentes seran Zangwill en Inglaterra y Luria en la Union Sovietica. Tambien se incluye un conflicto armado de menor repercusion geopolitica, la Guerra del Yom Kippur, que ejemplifica como los enfrentamientos belicos pueden estimular el desarrollo de programas de intervencion neuropsicologica. Conclusion. Los actuales programas de rehabilitacion neuropsicologica estan estrechamente vinculados a las intervenciones empleadas en tiempos de guerra por Goldstein, Zangwill o Luria. Los medios utilizados son distintos, pero los objetivos siguen siendo los mismos: ayudar a las personas con daño cerebral a ser capaces de adaptarse a su nueva vida.

  6. Cabergoline or bromocriptine for prolactinoma?

    PubMed

    Triantafilo, Nicolás; Castro-Gutiérrez, Victoria; Rada, Gabriel

    2016-09-15

    Cabergolina y bromocriptina son los fármacos más utilizados en el manejo del prolactinoma. Si bien cabergolina, un agonista dopaminérgico de vida media larga, tendría algunas ventajas desde el punto de vista fisiopatológico, no está claro si esto se traduce en un real beneficio. Utilizando la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en 30 bases de datos, identificamos dos revisiones sistemáticas que en conjunto comprenden 12 estudios relevantes para la pregunta, incluyendo cinco estudios controlados aleatorizados. Realizamos un metanálisis y tablas de resumen de los resultados utilizando el método GRADE. Concluimos que la cabergolina es superior a la bromocriptina en la mejoría de la oligomenorrea/amenorrea y la galactorrea, probablemente aumenta la probabilidad de embarazo, y se asocia a menos efectos adversos. No está claro si cabergolina también es más efectiva sobre el crecimiento del tumor porque la certeza de la evidencia es muy baja.

  7. [Assessment of the effectiveness and safety of Sativex® in compassionate use].

    PubMed

    Cimas-Hernando, Icíar; Pato-Pato, Antonio; Lorenzo-González, José R; Rodríguez-Constenla, Iria

    2015-03-01

    Introduccion. Sativex ® es un farmaco aprobado para el tratamiento de la espasticidad en la esclerosis multiple. Hemos querido estudiar la tolerabilidad y eficacia de este farmaco en patologias fuera de indicacion de ficha tecnica, mediante su uso compasivo. Objetivo. Valorar la eficacia y tolerabilidad de Sativex en patologias no incluidas en la ficha tecnica, mediante un protocolo de uso compasivo. Pacientes y metodos. Se realizo un estudio observacional, de seis meses de duracion, para evaluar la eficacia y tolerabilidad de Sativex en el dolor neuropatico y en la espasticidad de causa diferente a la esclerosis multiple. Resultados. Se incluyo un total de 10 pacientes, seis mujeres y cuatro hombres. Solo hubo efectos adversos en dos de ellos, y el farmaco se suspendio en un caso. Tras el inicio del tratamiento con Sativex mediante protocolo de uso compasivo, el consumo de farmacos concomitantes se redujo un 34,2% (p = 0,004), y se suspendio la administracion de toxina botulinica en siete pacientes (70%). La mejoria de la escala de espasticidad de Ashworth fue del 65,6% (p = 0,004) y la escala visual analogica disminuyo su puntuacion un 49,2% (p = 0,026). Conclusion. Sativex puede ser una alternativa terapeutica interesante en pacientes con espasticidad y dolor cuando se han utilizado los tratamientos habituales disponibles, pero los pacientes continuan con afectacion significativa de su calidad de vida.

  8. Telescópio de pequeno porte como suporte ao ensino em cidades com intensa poluição luminosa II

    NASA Astrophysics Data System (ADS)

    Pereira, P. C. R.; Santos-Júnior, J. M.; Cruz, W. S.

    2003-08-01

    Para a maioria dos estudantes, sua passagem pelo ensino formal fundamental envolve a transmissão de fatos que devem ser guardados para um exame, a habilidade para lembrar fórmulas e, eventualmente, a repetição de experimentos que devem produzir resultados exigidos pelo professor. O resultado deste modelo de ensino, ao longo dos anos, é conhecido por todos: desconhecimento e descontentamento, por parte dos estudantes, de temas relativos ao papel e aos processos da ciência. Acreditamos que a Astronomia, pelo seu caráter observacional, é uma das áreas do conhecimento que pode contribuir neste cenário. A Fundação Planetário da Cidade do Rio de Janeiro possui um telescópio Meade LX-200 (25cm) que, juntamente com as câmeras CCD ST-7E e ST8E, tem sido utilizado em projetos voltados aos estudantes do ensino médio desde o ano 2000. Tais projetos envolvem a condução de um projeto de pesquisa observacional num nível apropriado, e possibilitam o contato com técnicas e novas tecnologias: computador, software para manipulação de dados e gráficos, programas de tratamento e redução de dados, uso de equipamentos óptico-eletrônicos (telescópio e CCD), bem como o processo de aquisição de conhecimento. Dentro da proposta dos anos anteriores, priorizamos projetos de uma noite, ou seja, procuramos trabalhar com fenômenos que apresentem variabilidade com intervalo de recorrência relativamente curto. Em todos os casos, optamos pela fotometria diferencial, que tem se mostrado bastante eficiente para o céu luminoso como o da cidade do Rio de Janeiro. Neste painel, apresentamos alguns dos projetos desenvolvidos no último ano, com 25 estudantes. Apresentamos os resultados da observação da variável pulsante AI Vel (V = 6,6) e da variável cataclísmica FO Aqr (V = 13,5), e do monitoramento do trânsito da lua de Júpiter, Europa, ocorrido em 30 de abril de 2003. As curvas de luz produzidas para as primeiras estão concordantes com as da literatura, assim

  9. Classificação geométrica de galáxias bianeladas através do metódo CART (Classification And Regression Trees)

    NASA Astrophysics Data System (ADS)

    Ormeño, M. I.; Faúndez-Abans, M.; Cavada, G.

    2003-08-01

    A importância deste trabalho deve-se à seleção de objetos ainda não tratados particularmente como uma família e ao emprego de procedimento estatístico robusto que não precisa de pressupostos ou condições de contorno. Contribui, assim, ao melhor entendimento do cenário das Galáxias Aneladas do diagrama de Hubble via classificação e estudo de subclasses. Selecionaram-se 100 galáxias possuidoras de dois anéis do Catalog of Southern Ringed Galaxies compilado por Ronald Buta, de modo a construir uma amostra completa em termos de conhecimento dos semi-eixos dos anéis interno e externo projetados no plano do céu. Visando uma possível classificação destas galáxias aneladas normais em famílias de acordo com as características geométricas dos anéis, empregou-se primeiramente a Análise de Aglomerados (ferramenta de classificação: medições de semelhança em um espaço bidimensional) para explorar a possível existência de famílias. As variáveis analisadas foram: os diâmetros interiores menores d(I) e maiores D(I), os diâmetros exteriores menores d(E) e maiores D(E), e os ângulos de inclinação dos semi-eixos maiores interiores q(I) e exteriores q(E) dos anéis. Como metodologia de discriminação, empregou-se a construção de Árvores de Classificação. As árvores de classificação constituem um método de discriminação alternativo aos modelos clássicos, tais como a Análise Discriminante e a Regressão Logística, onde uma base de dados é dividida em partições (subgrupos) da árvore por ação de um predictor (variável específica). Os pacotes estatísticos utilizados para o processamento da informação foram: SAS versão 8.0 (Statistical Analisys System) e CART versão 3.6.3. Esta análise estatística sugere a existência de três possíveis famílias de galáxias bianeladas, com base apenas na geometria dos anéis. Como forma exploratória inicial deste resultado, a construção de um diagrama BT (magnitude total) versus o

  10. Inversor Resonante de Tres Elementos L-LC con Caracteristica Cortocircuitable para Aplicaciones de Calentamiento por Induccion

    NASA Astrophysics Data System (ADS)

    Espi Huerta, Jose Miguel

    Los generadores de calentamiento por induccion son puentes inversores con carga resonante, cuya mision es basicamente crear una corriente sinusoidal de gran amplitud sobre la "bobina de caldeo", que forma parte del tanque resonante. En el interior de esta bobina se introduce la pieza que se desea calentar. EI campo magnetico creado induce corrientes superficiales (corrientes de Foucault) sobre la pieza, que producen su calentamiento. Los tanques resonantes (tambien llamados osciladores) utilizados en la actualidad son el resonante serie y el resonante paralelo. Aunque ya desde hace algun tiempo se vienen construyendo generadores de alta potencia basados en estos dos osciladores, el exito nunca ha. sido completo en ninguno de los dos casos. Tal y como se explica en la introduccion de esta memoria, los puentes inversores utilizados deben operar sobre una carga inductiva (corriente retrasada) para evitar el fenomeno de la recuperacion inversa de sus diodos y la consiguiente ruptura de los transistores. De la restriccion topologica anterior se deduce que el generador paralelo debe conmutar a frecuencias inferiores a la resonancia, y el serie a frecuencias superiores. A esta restriccion topologica hay que unir otra que es exclusiva del calentamiento por induccion: La corriente por la bobina de caldeo debe ser sinusoidal. De no ser asi, resultaria imposible disponer toda la potencia de calentamiento sobre la pieza en el espesor requerido por la aplicacion. Como consecuencia, los inversores no pueden operar por debajo de la frecuencia de resonancia del oscilador, pues en ese caso se amplifican los armonicos de orden superior de la tension/corriente de entrada situados sobre la resonancia, con la consiguiente distorsion de la corriente de salida. La conjuncion de las dos restricciones anteriores obligan al inversor paralelo a funcionar a la frecuencia de resonancia del oscilador. Esto imposibilita un control por variacion de frecuencia, regulandose la potencia desde la

  11. On Ensino da Astronomia no Ensino Médio sob Diferentes Abordagens Metodológicas

    NASA Astrophysics Data System (ADS)

    Voelzke, Marcos Rincon; Albrecht, Evonir

    2011-12-01

    O presente trabalho, sobre a intervenção de metodologias de ensino, foi desenvolvido na Escola Estadual Colônia dos Pescadores, na cidade de Caraguatatuba - SP, em três turmas do terceiro ano do Ensino Médio, perfazendo um total de 119 educandos, entre 16 e 19 anos. Antes de iniciar-se a intervenção, um questionário de vinte perguntas objetivas e dissertativas foi desenvolvido, aplicado pelo professor da classe, que ministrou as aulas correspondentes. Este questionário foi o mesmo em todas as três classes com o objetivo de diagnosticar o conhecimento prévio dos alunos sobre Astronomia. Começando a intervenção nas turmas, o professor envolvido usou três diferentes metodologias de ensino: (A) em forma de seminários, elaborados e apresentados pelos alunos, nos quais o professor fazia apenas as intervenções necessárias, (B) na forma tradicional, com a ajuda de multimídia para o desenvolvimento das aulas e a terceira (C) a tradicional, fazendo uso exclusivo de lousa e giz. No final do trabalho os alunos responderam o mesmo questionário novamente, de modo que os três métodos utilizados puderam ser comparados. Os resultados apresentados após a intervenção foram melhores que os resultados iniciais indicando a ocorrência de uma aprendizagem significativa. Quando os estudantes foram inicialmente questionados sobre quantos planetas existem no nosso sistema solar, a classe A obteve 39% de respostas certas, a classe B 48% e a classe C 46%, mas após o desenvolvimento das atividades, as classes obtiveram respectivamente 94%, 97 % e 90% de aproveitamento. No término do bimestre, foi sugerido aos educandos que elaborassem uma história em quadrinhos, a qual serviu para averiguar se os conceitos inicialmente observados foram alterados e se novos foram agregados. A análise das histórias foi dividida em três partes: Criatividade; Temas abordados; Emprego correto dos conceitos estudados. Ao final quatorze histórias foram confeccionadas. O aprendizado

  12. Association between serum uric acid levels and obesity among university students (China).

    PubMed

    Duan, Ying; Liang, Wei; Zhu, Lijun; Zhang, Ting; Wang, Linghong; Nie, Zhognhua; Chen, Yan; He, Lianping; Jin, Yuelong; Yao, Yingshui

    2015-06-01

    Objetivo: evaluar la asociación entre el ácido úrico en suero y la obesidad entre los estudiantes universitarios que participaron en los exámenes de salud de rutina en 2013. Métodos: en este estudio transversal, 3.529 sujetos fueron analizados. La obesidad categorías fueron clasificados por el IMC niveles referencias en China.Y los niveles de ácido úrico en suero fueron clasificados por el ácido úrico en suero cuartiles. Dos Sample T - test y Wilcoxon Rank sum test se utiliza para comparar los parámetros antropométricos, bioquímicos y de los sujetos de ambos sexos. Rango correlación utilizado para analizar la relación entre el ácido úrico en suero y la obesidad. Resultado: hay 1.285 hombres (edad media, 19,8 ± 1,3 años) y 2.244 mujeres (edad media, 19,9 ± 1,3 años) en este estudio. Asociación entre el segundo cuartil de ácido úrico en suero y normal en el macho son significativos y se 0,519 coeficiente. El tercer cuartil de ácido úrico en suero y normal en mujeres se asoció significativamente (R = 0,173, p = 0,010). Y asociaciones entre sobrepeso y 3º y 4º de ácido úrico sérico cuartiles en mujeres fueron significativa (R = 0,128, p = 0,038 en 1er cuartil y R = 0,317, p = 0,004 en cuarto cuartil). El cuarto cuartil de ácido úrico en suero y la obesidad en dos grupos de género fueron asociados significativamente (R = 0,286, p = 0,000 en macho y R = 0,484, p = 0,001 en mujeres). Conclusión: alta de ácido úrico en suero fue asociado positivamente con la obesidad en el sobrepeso y la obesidad. Sin embargo, la asociación entre dos variables es débil porque el ácido úrico en suero influenciado la obesidad con otros factores conexos.

  13. [Mini-Mental State Examination: Screening and Diagnosis of Cognitive Decline, Using New Normative Data].

    PubMed

    Santana, Isabel; Duro, Diana; Lemos, Raquel; Costa, Vanessa; Pereira, Miguel; Simões, Mário R; Freitas, Sandra

    2016-04-01

    Introdução: O Mini-Mental State Examination é o teste de rastreio de défice cognitivo/demência mais difundido. No nosso país têm-se utilizado pontuações de corte definidas por grupos de literacia, mas existem novas propostas sustentadas por estudos mais representativos. Propomo-nos confirmar a influência da idade e da escolaridade no desempenho, avaliar a capacidade discriminativa dos novos dados normativos e testar a acuidade diagnóstica das pontuações de corte validadas para o défice cognitivo ligeiro e para as formas mais prevalentes de demência. Material e Métodos: O estudo incluiu 1 441 participantes escolarizados, divididos em sete subgrupos: Défice cognitivo ligeiro, doença de Alzheimer, demência fronto-temporal, demência vascular, demência com corpos de Lewy, controlo-comunidade e controlo-clínica- memória. Resultados: Em conjunto, idade e escolaridade explicam 10,4% da variância dos resultados no Mini-Mental State Examination, com ambas contribuindo significativamente para a predição dos resultados. A acuidade diagnóstica com base nos dados normativos mais recentes foi sempre superior à conseguida com as pontuações de corte de validação, revelando uma especificidade excelente (superior a 90%) e uma sensibilidade também excelente para a doença de Alzheimer ligeira (91%), boa para demência com corpos de Lewy (78%), baixa para o défice cognitivo ligeiro (65%) e demência fronto-temporal e demência vascular (55%). Discussão e Conclusões: O desempenho no Mini-Mental State Examination é influenciado pela idade e pela escolaridade, apoiando a utilização de dados normativos que considerem estas variáveis. Com esta abordagem, o Mini-Mental State Examination poderá ser um instrumento sensível e específico para o rastreio da doença de Alzheimer em todos os níveis de cuidados de saúde, mas a acuidade de diagnóstico é limitada noutras situações frequentes em consultas especializadas, como o défice cognitivo ligeiro

  14. [Validity and reproducibility of a food frequency questionnaire to assess lipid and phytochemical intake].

    PubMed

    Perovic, Nilda R; Defago, Maria D; Aguinaldo, Anabel; Joekes, Silvia; Actis, Adriana B

    2015-01-01

    Antecedentes: estudios epidemiológicos sugieren que el consumo de ciertos alimentos puede reducir el riesgo de enfermedades no transmisibles (ENT). Objetivo: analizar la validez y reproducibilidad de un cuestionario de frecuencia de consumo alimentario (FFQ) destinado a evaluar la ingesta de lípidos y fitoquímicos. Material y métodos: el FFQ fue administrado a 45 personas de ambos sexos, con edades entre 20 y 72 años de edad, residentes en Córdoba, Argentina. Incluyó 257 preguntas referidas a los alimentos, su frecuencia de consumo y tamaño de la porción. Se consideró la estacionalidad para el consumo de frutas y verduras. El cuestionario se aplicó en dos períodos diferentes (FFQ1 y FFQ2) con un intervalo de seis meses y se acompañó por un recordatorio de 24 horas (24HDR) utilizado en tres periodos de tiempo. Se realizó la estimación de: ingesta promedio FFQ1-FFQ2 y 24HDR-FFQ2, diferencia de medias, desviación absoluta de diferencias de medias, prueba de los rangos con signo de Wilcoxon y test de correlación de Spearman. Resultados: los coeficientes de correlación para FFQ1-FFQ2 variaron de 0,52 para el ácido graso eicosapentanoico 20:5 n3 (EPA) a 0,89 para ácido graso butírico 4:0 (p<0,05). Para 24HDR-FFQ2, los valores de correlación oscilaron entre 0,19 para licopeno y 0,93 para el EPA (p <0,05). Conclusión: el análisis realizado mostró una validez aceptable y reproducibilidad del FFQ, permitiendo así que sea utilizado en investigaciones sobre ingesta de lípidos y fitoquímicos y el riesgo de ENT.

  15. Quality of Recovery after Anesthesia: Validation of the Portuguese Version of the 'Quality of Recovery 15' Questionnaire.

    PubMed

    Sá, Ana Carolina; Sousa, Gabriela; Santos, Alice; Santos, Cristina; Abelha, Fernando José

    2015-01-01

    Introdução: O questionário "Quality of Recovery 15" tem sido utilizado para o estudo da qualidade de recuperação após anestesia. O objetivo deste estudo foi validar a versão Portuguesa do questionário "Quality of Recovery 15". Material e Métodos: Após aprovação pela Comissão de ética institucional, foi realizado um estudo de coorte prospectivo em doentes submetidos a cirurgia eletiva de junho a agosto de 2013. A versão portuguesa do "Quality of Recovery 15" foi aplicada antes da cirurgia (T0) e 24 h após a cirurgia (T1) em 170 doentes. Os doentes incapazes de dar consentimento informado ou com comprometimento cognitivo foram excluídos. Má qualidade de recuperação foi definida para pontuações de "Quality of Recovery 15" em T1 inferiores à média das pontuações de "Quality of Recovery 15" menos 1 desvio padrão. Confiabilidade e discordãncia entre observadores foram avaliadas por meio da correlação intraclasse. Testes não-paramétricos foram utilizados para comparações. Resultados: Observou-se uma correlação negativa entre pontuações de "Quality of Recovery 15" e tempo de internamento na Unidade Pós-Anestésica (p = -0,264, p = 0,004) e tempo de internamento hospitalar (p = -0,274, p = 0,004). Trinta e dois doentes (19%) tiveram má qualidade de recuperação. Os doentes com má qualidade de recuperação tinham mais frequentemente diabetes mellitus e hipertensão arterial e estavam medicados com antidepressivos com mais frequência. Os doentes com má qualidade de recuperação foram mais frequentemente submetidos a anestesia combinada e menos frequente a anestesia geral e locorregional (p = 0,008). O questionário teve boa consistência interna; a confiabilidade do teste-reteste foi boa. Discussão: A versão portuguesa do "Quality of Recovery 15" mostrou boa correlação com a versão original. Conclusão: Este questionário parece ser uma avaliação precisa e confiável para a qualidade de recuperação.

  16. [Allergic contact dermatitis to metals over a 20-year period in the Centre of Portugal: evaluation of the effects of the European directives].

    PubMed

    Teixeira, Vera; Coutinho, Inês; Gonçalo, Margarida

    2014-01-01

    Introdução: Os metais são causa frequente de dermatite de contacto alérgica. Desde a introdução da Directiva Comunitária do Níquel (1994/27/CE; 2004/96/CE) e, mais recentemente, da Directiva do Cimento (2003/53/CE), nos países nórdicos tem havido uma diminuição da sensibilização aos metais. A aplicabilidade destas medidas e o seu impacto permanece por avaliar em Portugal. Material e Métodos: Foi realizado um estudo retrospectivo (1992-2011) na Consulta de Alergologia Cutânea com o principal objectivo de analisar a variação dos padrões de sensibilização aos metais (níquel [Ni], cobalto [Co] e crómio [Cr]) ao longo de 20 anos, em particular no que se refere ao género, grupo etário e relação com a actividade profissional. Resultados: Do total de 5 250 doentes estudados, em 1 626 (31%) observámos pelo menos um teste epicutâneo positivo a um metal (26,5% ao Ni; 10,0% ao Co e 7,0% ao Cr). A prevalência de sensibilização ao Ni era significativamente maior nas mulheres (34,4% versus 8,9%) e ao Cr nos homens (11,5% versus 5,0%). Não houve diminuição significativa da sensibilização ao Ni ao longo dos 20 anos, mas o contributo da faixa etária dos 16-30 anos no total de mulheres sensíveis a este metal decresceu de forma significativamente estatística ao longo dos anos (p < 0,001). A sensibilização ao Cr decresceu sobretudo nos homens (r = -0,535), muito particularmente nos casos relacionados com a construção civil (r = -0,639), enquanto a reatividade ao Cr relacionado com o uso de calçado se manteve estável. Discussão: A manutenção dos elevados níveis de sensibilização ao níquel denota ainda uma fraca implementação das Directivas comunitárias mas a redução da percentagem de mulheres jovens poderá significar já algum efeito positivo nesta faixa etária. Ao contrário, a Directiva referente à redução do Cr no cimento parece estar a ter os seus efeitos positivos. Há, contudo, necessidade de interferir com o conte

  17. Integrated disease management: a critical review of foreign and Portuguese experience.

    PubMed

    Coelho, Anabela; Leone, Cláudia; Ribeiro, Vanessa; Sá Moreira, Pedro; Dussault, Gilles

    2014-01-01

    Introdução: O artigo faz uma revisão de literatura sobre os programas de gestão integrada da doença, apresentando resultados sobre o nível de integração dos cuidados, as intervenções prioritárias utilizadas nos programas e o seu efeito, nomeadamente, nos doentes.Material e Métodos: A revisão de literatura identificou 1 251 artigos, publicados entre 2006 e 2011. Depois de uma criteriosa seleção identificaram-se para a análise bibliométrica e discussão crítica, 61 artigos.Resultados: Realçamos o facto de serem os Estados Unidos da América o país que mais publica sobre esta matéria; A doença mais reportada é a diabetes mellitus e o domínio de intervenção da gestão integrada da doença, predominante, é o ‘apoio ao auto-cuidado’. A maioria dos estudos foram implementados por managed care organizations, médicos de medicina geral e familiar organizados para o efeito ou hospitais. Das 360 intervenções reportadas, as mais utilizadas são as dirigidas aos doentes e aos profissionais. Os resultados mais observados nos doentes, aquando da monitorização dos programas, são: resposta clínica, utilização de serviços e estado de saúde.Discussão: Cada país tem a sua própria forma de implementar a estratégia de gestão integrada da doença. O foco de atenção da prática clínica é o empoderamento dos doentes, particularmente através da promoção da auto-gestão. Os resultados clínicos e os de utilização dos serviços para além de serem os mais utilizados, são também, aqueles com maior impacto nos programas de gestão integrada da doença.Conclusão: O sistema de saúde Português ainda enfrenta sérios desafios no tocante à coordenação e integração de cuidados dirigidos à pessoa com doença crónica pelo que se sugere a atualização do programa.

  18. [European Portuguese EARS test battery adaptation].

    PubMed

    Alves, Marisa; Ramos, Daniela; Oliveira, Graça; Alves, Helena; Anderson, Ilona; Magalhães, Isabel; Martins, Jorge H; Simões, Margarida; Ferreira, Raquel; Fonseca, Rita; Andrade, Susana; Silva, Luís; Ribeiro, Carlos; Ferreira, Pedro Lopes

    2014-01-01

    Introdução: A utilização de instrumentos de avaliação em saúde adequados é fundamental na gestão da prestação de cuidados. A escassez, em Portugal, de instrumentos específicos para a avaliação do desempenho de crianças utilizadoras de implantes cocleares motivou o trabalho de tradução e de adaptação da bateria de testes EARS (Evaluation of Auditory Responses to Speech) para o português europeu. Esta bateria de testes é hoje um dos instrumentos mais comummente utilizados por equipas de (re)habilitação de crianças surdas com implantes cocleares em todo o mundo. O objetivo a atingir com a validação do EARS foi fornecer às equipas de (re)habilitação um instrumento que permita: (i) monitorizar a evolução individual da reabilitação; (ii) gerir um programa de (re)habilitação de acordo com resultados objetivos, comparáveis entre diferentes equipas de (re)habilitação; (iii) obter dados comparáveis comequipas internacionais; e (iv) melhorar a adesão e a motivação da família e restantes profissionais no ambulatório.Material e Métodos: No processo de tradução e de adaptação da bateria de testes, os procedimentos adotados foram os seguintes: (i) tradução da versão inglesa para português europeu por um tradutor profissional; (ii) revisão dessa tradução realizada por um painel de especialistas constituído por otorrinolaringologistas, terapeutas da fala e técnicos de audiologia; (iii) adaptação dos estímulos de teste pela equipa de terapeutas da fala; e (iv) nova revisão por parte do painel de especialistas.Resultados: São apresentados, para cada um dos instrumentos que compõem a bateria EARS, as adaptações introduzidas, conciliando as características e os objetivos originais dos instrumentos com as particularidades linguísticas e culturais da população portuguesa.Discussão: São discutidas as dificuldades encontradas durante o processo de tradução e de adaptação e as soluções adotadas. São feitas

  19. DIMED 86: Discurso dos Media e Ensino a Distancia = Discours des Media et Enseignement a Distance = Media Speech and Distance Teaching. Papers Presented at a Seminar (21st, Algarve, Portugal, March 10-15, 1986).

    ERIC Educational Resources Information Center

    Coelho, Maria Eduarda Leal

    Presentations at this seminar on distance education focused on the different types of speech in multimedia presentations which contribute to the elaboration (simulated or substituted) of a situation involving different relationships. In addition to opening and closing remarks by Marcel de Greve and a final report by the Scientific Committee of…

  20. Adenoviruses of canine and human origins in stool samples from free-living pampas foxes (Lycalopex gymnocercus) and crab-eating foxes (Cerdocyon thous) in São Francisco de Paula, Rio dos Sinos basin.

    PubMed

    Monteiro, G S; Fleck, J D; Kluge, M; Rech, N K; Soliman, M C; Staggemeier, R; Rodrigues, M T; Barros, M P; Heinzelmann, L S; Spilki, F R

    2015-05-01

    The spread of enteric viruses of domestic animals and human beings to wild species can be facilitated by the resistance of these viruses on the environment and their ability to be transmitted by water and contaminated food. The health status of the populations of pampas foxes Lycalopex gymnocercus) and crab-eating foxes (Cerdocyon thous) is largely unknown and the landscapes occupied by these animals in southern Brazil have been threatened by human occupation and expansion of agriculture. In this work, the search of genomes of human and canine adenoviruses in feces from these wild carnivores was used to track the dissemination of domestic animals and human pathogens to the free-living populations in a wildlife reserve located in southern Brazil. This was performed by virus-specific differential real-time polymerase chain reactions (qPCR) on stool specimens, avoiding capture and additional stress to the animals. Genus-specific conventional reverse-transcriptase PCR (RT-PCR) was complementarily performed aiming the detection of enteroviruses (EV) and rotaviruses (RV) on these same samples. HAdV genomes were found on 14 out of the 17 (82.35%) stool samples analysed, whereas CAV was found co-infecting 5 of these samples. RV genomes were detected on 7 of the 17 samples (41.18%) and all samples were negative for EV. The results point to the dispersion of HAdV and RV at a high rate to these species of South American wild carnivores, which can be an effect of growing anthropisation of the habitat of these animals.

  1. Linking the Modern and Recent Record of Cabo Frio Upwelling with Local Climate and Biogeochemical Processes in Hypersaline Coastal Lagoons, Região dos Lagos, Rio de Janeiro, Brazil

    NASA Astrophysics Data System (ADS)

    McKenzie, J. A.; Nascimento, G. S.; Albuquerque, A. L.; Belem, A. L.; Carreira, R.; Eglinton, T. I.; Vasconcelos, C.

    2015-12-01

    A unique marine and lagoonal system along the coast east of Rio de Janeiro is being investigated to understand the impact of climatic variability on the South Atlantic carbon cycle and biomineralisation processes involved in carbonate precipitation in the hypersaline coastal lagoons. The region is dominated by a semi-arid microclimate attributed to the local coastal upwelling phenomenon near Cabo Frio. The intensity of the upwelling affects the hydrology of the annual water and biogeochemical cycles in the lagoons, as well as biogeochemical signals of environmental change recorded in both onshore and offshore sediments. Preliminary results of δ18O and δD values of water samples collected monthly in Lagoa Vermelha and Brejo do Espinho from 2011 to 2014 show lower values for waters corresponding to the wet season, reflecting increased input of meteoric water. The higher values for waters collected during the dry season reflect the greater amount of evaporation with increased seasonal aridity. Radiocarbon dating of Holocene marine and lagoonal cores indicates that Mg-carbonate precipitation in the lagoons is associated with high evaporation. Modern field observations for the last 3 years suggest that the amount of carbonate precipitation is correlated with evaporitic conditions associated with the upwelling phenomenon. A calibration study of hydrogen isotopic fractionation in the modern lagoons is underway to define a relationship between δDlipid of suspended particles and δDwater of associated water. This isotopic relationship will be applied to material obtained in cores from the lagoons. Offshore cores will be studied using well-tested paleotemperature proxies to evaluate the intensity of the upwelling during the Holocene. In summary, linking the coastal upwelling with the lagoonal hydrology has the potential to furnish important insights about the relationship between the local climate and paleoceanographic circulation associated with the regional carbon cycle.

  2. Geochronology and Nd isotope geochemistry of the Gameleira Cu-Au deposit, Serra dos Carajás, Brazil: 1.8-1.7 Ga hydrothermal alteration and mineralization

    NASA Astrophysics Data System (ADS)

    Pimentel, Márcio M.; Lindenmayer, Zara G.; Laux, Jorge H.; Armstrong, Richard; de Araújo, Janice Caldas

    2003-01-01

    The Gameleira deposit is one of several important Cu-Au deposits associated with the late Archean (ca. 2.7 Ga) volcanic rocks of the Itacaiúnas supergroup in the Carajás mineral province, southeastern Pará. It comprises mainly biotite- and sulphide-rich veins and quartz-grunerite-biotite-gold hydrothermal veins that cut andesitic rocks. It is interpreted as representative of the Fe oxide Cu-Au class of deposit. Sm-Nd isotopic data indicate an age of 2719±80 Ma (MSWD=3.0) and ɛNd( T) of -1.4 for the host meta-andesites. Metavolcanic rocks and cogenetic gabbros give an age of 2757±81 Ma (1 σ) with ɛNd( T) of -0.8. This is considered the best estimate for the crystallization age of the Gameleira volcanic and subvolcanic rocks. Negative ɛNd( T) and Archean TDM model ages (mostly between 2.8 and 3.1 Ga) suggest some contamination with older crustal material. The andesitic/gabbroic rocks are cut by two generations of granite dykes. The older has striking petrographic and geochemical similarities to the ca. 1.87 Ga alkali-rich Pojuca granite, which is exposed a few kilometers to the northwest of the deposit. The younger is a leucogranite with a U-Pb SHRIMP age of 1583+9/-7 Ma. Neodymium isotopic analyses of the two generations of granites indicate a strong crustal affinity and possible derivation from reworking of the Archean crust. The quartz-grunerite-gold hydrothermal vein yields a Sm-Nd isochron (MSWD=.83) age of 1839±15 Ma (1 σ) with ɛNd( T) of -9.2. Pervasive potassic alteration, represented by the widespread formation of biotite in the country rocks, is dated by Ar-Ar at 1734±8 Ma, and a similar age of 1700±31 Ma (1 σ) is indicated by the Sm-Nd isochron for the biotite-sulphide veins. Similar to that for the quartz-grunerite vein, the ɛNd( T) value for the sulphide-rich veins is strongly negative (-8.2), thereby suggesting that the original fluids percolated through, leached, or were derived from igneous rocks with an Archaean Nd isotopic signature. The geochronological data suggest that the Gameleira Cu-Au mineralization is related to a Paleoproterozoic (ca. 1.83 Ga) episode of hydrothermal activity and is not Archaean. The younger ages of ca. 1.70-1.73 might be interpreted as products of the lower blocking temperatures of biotite in relation to the Ar-Ar and Sm-Nd isotopic systems. Combined with previous geochemistry and stable isotope data, the Nd isotopic data suggest that the mineralizing fluids were derived from, or strongly interacted with, a Paleoproterozoic crustal granite, possibly similar in age and composition to the Pojuca granite.

  3. [The occurrence of Biomphalaria straminea (Pulmonata: Planorbidae) on an aquaculture farm of IBAMA in Uberlândia, MG. Instituto Brasileiro do Meio Ambiente a dos Recursos Naturais Renováveis].

    PubMed

    Silveira, E de P; Marçal Júnior, O; Machado, M I

    1997-01-01

    This work evaluates the occurrence of freshwater snails in the IBAMA's fish breeding station in Uberlândia, Minas Gerais State. We verified the presence of Biomphalaria straminea in 39.5% of all breeding tanks. None of the snails were infected by Schistosoma mansoni, but further investigation should be done in the area.

  4. Adenoviruses of canine and human origins in stool samples from free-living pampas foxes (Lycalopex gymnocercus) and crab-eating foxes (Cerdocyon thous) in São Francisco de Paula, Rio dos Sinos basin.

    PubMed

    Monteiro, G S; Fleck, J D; Kluge, M; Rech, N K; Soliman, M C; Staggemeier, R; Rodrigues, M T; Barros, M P; Heinzelmann, L S; Spilki, F R

    2015-05-01

    The spread of enteric viruses of domestic animals and human beings to wild species can be facilitated by the resistance of these viruses on the environment and their ability to be transmitted by water and contaminated food. The health status of the populations of pampas foxes Lycalopex gymnocercus) and crab-eating foxes (Cerdocyon thous) is largely unknown and the landscapes occupied by these animals in southern Brazil have been threatened by human occupation and expansion of agriculture. In this work, the search of genomes of human and canine adenoviruses in feces from these wild carnivores was used to track the dissemination of domestic animals and human pathogens to the free-living populations in a wildlife reserve located in southern Brazil. This was performed by virus-specific differential real-time polymerase chain reactions (qPCR) on stool specimens, avoiding capture and additional stress to the animals. Genus-specific conventional reverse-transcriptase PCR (RT-PCR) was complementarily performed aiming the detection of enteroviruses (EV) and rotaviruses (RV) on these same samples. HAdV genomes were found on 14 out of the 17 (82.35%) stool samples analysed, whereas CAV was found co-infecting 5 of these samples. RV genomes were detected on 7 of the 17 samples (41.18%) and all samples were negative for EV. The results point to the dispersion of HAdV and RV at a high rate to these species of South American wild carnivores, which can be an effect of growing anthropisation of the habitat of these animals. PMID:26270208

  5. [Neurological complications of tick-borne relapsing fever].

    PubMed

    Castilla-Guerra, L; Fernandez-Moreno, M C; Vergara-Lopez, S; Merino-Rumin, M; Colmenero-Camacho, M A

    2016-09-16

    Introduccion. La fiebre recurrente transmitida por garrapatas (FRTG) puede producir complicaciones neurologicas. No existen apenas estudios en España sobre el tema. Objetivo. Estudiar la prevalencia y las caracteristicas clinicas de las complicaciones neurologicas de los pacientes con FRTG. Pacientes y metodos. Estudio retrospectivo de los pacientes atendidos con FRTG durante 12 años (2004-2015) en un hospital de una zona rural del sur de España. Resultados. Se incluyeron 75 pacientes, 42 varones (56%), con una edad media de 33 años (rango: 14-72 años). Se observaron picaduras de garrapatas en nueve pacientes (12%). Los sintomas mas frecuentes fueron: fiebre en 64 pacientes (85,3%), cefalea en 41 (54,6%) y vomitos en 26 (34,6%). Se sospecho afectacion meningea en nueve pacientes (12%), de los que tres (4%) tenian signos meningeos en el momento del ingreso. A todos ellos se les realizo una puncion lumbar. Ninguno presento paralisis facial ni otra manifestacion neurologica. Se encontraron alteraciones del liquido cefalorraquideo en los tres pacientes con meningismo. En uno de los casos se visualizo Borrelia en el liquido cefalorraquideo. En los pacientes con afectacion neurologica, el tratamiento utilizado fue penicilina G en un caso y ceftriaxona en dos. Todos los pacientes se recuperaron completamente. Conclusiones. La FRTG es una de las formas menos graves de borreliosis, y menos del 5% de los pacientes presenta complicaciones neurologicas. Sin embargo, los medicos deben saber que Borrelia puede causar meningitis en los sujetos expuestos a garrapatas en regiones endemicas de FRTG.

  6. TIBIOTARSAL COMPRESSION ARTHRODESIS USING A LATERAL LOCKING PLATE.

    PubMed

    Coughlin, Michael J; Nery, Caio; Baumfeld, Daniel; Jastifer, James

    2012-01-01

    Objetivos: A artrodese tibiotársica (TT) continua sendo uma importante opção no tratamento da artrose primária ou pós-traumática do tornozelo mas persiste ainda a controvérsia sobre o melhor método de fixação do foco de artrodese. Independentemente do tipo de material utilizado, o objetivo maior é a obtenção da fusão articular sólida, saudável e indolor. O propósito do presente estudo é apresentar os resultados preliminares de um novo sistema de placa bloqueada lateral compressiva para a artrodese do tornozelo. Método: Treze pacientes consecutivos portadores de artrose tibiotársica foram submetidos à artrodese do tornozelo nove pacientes eram homens e quatro mulheres. Com o auxílio de um guia, as superfícies articulares do talo e da tíbia foram decorticadas. Um sistema de compressão foi aplicado para evitar o alinhamento indesejável dos segmentos e uma placa bloqueada pré-moldada lateral foi utilizada para obter a fusão articular. Resultados: Tanto o escore AOFAS quanto o VAS melhoraram com a cirurgia. Todos os tornozelos operados consolidaram dentro do prazo de seis meses. Em todos os pacientes, foi obtido um ótimo alinhamento nos planos sagital, coronal e transverso. Conclusão: Acreditamos que a combinação de compressão bilateral, cortes ósseos com contornos pré-demarcados e placa lateral bloqueada, constitui uma técnica moderna, segura e útil para a artrodese do tornozelo.

  7. Prolonged flaxseed flour intake decreased the thickness of the aorta and modulates some modifiable risk factors related to cardiovascular disease in rats.

    PubMed

    Cardozo, Ludmila Ferreira Medeiros de França; Vicente, Gabriela Câmara; Brant, Lívia Hipólito Cardozo; Mafra, Denise; Chagas, Maurício Alves; Boaventura, Gilson Teles

    2014-02-01

    Las enfermedades cardiovasculares son un problema de salud pública. Diferentes factores de riesgo han sido reconocidos como las principales causas del desarrollo y la progresión de las enfermedades cardiovasculares. La linaza es una fuente de fibra dietética, lignanos, y el ácido alfa-linolénico. El objetivo de este estudio fue evaluar los efectos de la suplementación prolongada con harina de linaza como tratamiento preventivo de los parámetros de riesgo cardiovascular en ratas Wistar saludables. Material y métodos: Ratas hembras Wistar fueron divididas en dos grupos después de dar a luz y durante el perío do de lactancia: el grupo de control fue alimentado con una dieta basada en caseína y el grupo de la linaza se alimentó con una dieta basada en caseína que contiene 25% de harina de linaza. Al destete, 10 ratas macho de la camada de cada grupo siguió recibiendo las mismas dietas de sus madres durante 250 días. El peso corporal, la masa grasa visceral, colesterol, triglicéridos, HDL, VLDL, la glucosa y el grosor de la aorta fueron analizado. Resultados: El peso corporal, la masa grasa visceral, colesterol, triglicéridos, HDL, VLDL, la glucosa y el grosor de la aorta esos valores fueron estadísticamente menor en comparación con el grupo control. Conclusión: Los datos sugieren que la suplementación con harina de linaza en ratas Wistar saludables durante un período prolongado puede disminuir el espesor de la aorta y puede ser utilizado como una medida preventiva en la modulación de algunos factores de riesgo modificables relacionados con la enfermedad cardiovascular.

  8. [Thermolabile drugs stability faced with an accidental interruption in the cold chain].

    PubMed

    Ricote-Lobera, I; Ortiz-Martín, B; Fraile-Gil, S; Santos-Mena, B; Hidalgo-Correas, F J; García-Díaz, B

    2014-05-01

    Objetivo: Elaborar una guía actualizada sobre la estabilidad delos medicamentos termolábiles incluidos en la Guía Farmacoterapéuticaque, según ficha técnica, deben conservarse bajorefrigeración o congelación, expuestos accidentalmente a temperaturasde conservación fuera del rango recomendado por elfabricante.Métodos: Se revisó la información sobre las temperaturas deconservación recomendadas en ficha técnica y los datos deestabilidad disponibles a distintas temperaturas de los medicamentostermolábiles incluidos en la Guía Farmacoterapéuticade un hospital de 400 camas que, según el fabricante, debenconservarse bajo refrigeración o congelación. Se excluyeron losmedicamentos incluidos en ensayos clínicos. Los datos de estabilidadse obtuvieron a partir de la ficha técnica, la informacióncontenida en las dos últimas guías de conservación de medicamentostermolábiles publicadas en España y a través de las consultasrealizadas a los laboratorios (vía telefónica o por e-mail).Resultados: Se confeccionó una tabla con las temperaturas deconservación recomendadas en ficha técnica y los datos deestabilidad disponibles actualmente a distintas temperaturas de209 presentaciones de distintas especialidades farmacéuticas.Se solicitaron datos de estabilidad actualizados de 172 de ellasa los laboratorios.Conclusiones: La guía elaborada constituye una herramientaque facilita la toma de decisiones del farmacéutico ante unarotura accidental de la cadena de frío, cuando sea necesarioconocer si el fármaco puede ser utilizado y no sea posible contactarcon el laboratorio fabricante.

  9. [Protein supplement consumption and its possible association with kidney damage in Mexican elite athletes].

    PubMed

    Pomerantz, Alan; Blachman-Braun, Ruben; Vital-Flores, Socorro; Berebichez-Fridman, Roberto; Aguilar-Mendoza, Juan Pablo; Lara-Villalón, David

    2016-01-01

    Introducción: los suplementos proteicos son unos de los suplementos ergogénicos más utilizados por los atletas de alto rendimiento. Sin embargo, se ha postulado que el consumo de estos pudiese ser causa de insuficiencia renal crónica. El objetivo fue analizar los efectos del consumo de suplementos proteínicos en la función renal de los atletas de alto rendimiento del Centro Deportivo Olímpico Mexicano. Métodos: se evaluaron 74 atletas, en cuya muestra de orina se cuantificaron las proteínas. Se excluyeron los atletas con antecedentes o condiciones que pudiesen causar proteinuria o que pudieran alterar la calidad de la muestra. Los elegidos se dividieron en dos grupos con base en el antecedente de consumo de suplemento proteico: el grupo experimental lo conformaron los consumidores y el control los no consumidores. Resultados: de 74 atletas analizados, 44 fueron excluidos, 11 se incluyeron al grupo experimental y 19 al grupo control. Se obtuvo un resultado positivo para microproteinuria en este último grupo. Se determinó estadísticamente que ambos grupos eran similares y se estableció, en relación con el resultado positivo de microproteinura, que no existe una diferencia significativa entre ambos grupos. Conclusión: el consumo de suplemento proteico no ha afectado la función renal de los atletas analizados. Pese a esto, consideramos que la seguridad del suplemento proteico debe ser evaluada en un futuro en ciertos grupos con patologías o antecedentes que pudieran comprometer la función renal.

  10. The prevalence of overweight and obesity in adolescents in Bahia, Brazil.

    PubMed

    Ferreira Marques, Cibele Dantas; Ribeiro Silva, Rita de Cássia; Machado, Maria Ester C; Portela de Santana, Mônica Leila; Castro de Andrade Cairo, Romilda; Pinto, Elizabete de Jesus; Oliveira Reis Maciel, Leonardo; Rodrigues Silva, Luciana

    2013-01-01

    Objetivo: Un estudio transversal se llevó a cabo con 1477 estudiantes de primaria matriculados en las escuelas públicas de Salvador, Bahía, Brasil, para evaluar la prevalencia del sobrepeso y la obesidad. Métodos: La muestra se determinó por la técnica de muestreo por conglomerados en dos etapas para la selección de escuelas y clases. Más tarde, posteriori error se calculó. Los estudiantes fueron clasificados como sobrepeso u obesos de acuerdo con la clasificación de la Organización Mundial de la Salud, 2007. Ellos también fueron clasificados de acuerdo a la edad, la etapa de maduración sexual, y la presencia de obesidad abdominal. Resultados: En general, el 9,3% de los estudiantes tenían sobrepeso y el 6,4% eran obesos, por lo tanto, el 15,7% de los alumnos se considera que tienen exceso de peso (sobrepeso + obesidad), con un intervalo de confianza del 95%. De la población total estudiada el 12,9% presentaron obesidad abdominal, esta condición se observa en el 13% de su peso normal. Se encontró asociación entre el sobrepeso y la edad < 14 AÑOs (p = 0,030) y obesidad abdominal (p = 0,001). Conclusiones: Los programas de intervención deben ser implementados para prevenir y tratar la obesidad en la infancia y la adolescencia. Además, los profesionales que trabajan con las personas en este grupo de edad deben ser sensibles a este problema. La necesidad de estandarizar los indicadores antropométricos utilizados en los diferentes estudios se enfatiza también.

  11. [Trend of antimicrobial susceptibility in a neonatal and pediatric intensive care unit].

    PubMed

    Vázquez-Solís, María G; Villa-Manzano, Alberto I; Medina-García, Luis H; Zamora-López, X Xitlalli; Pulido-Galaviz, Carlos; Zamora-López, Daniel F

    2016-01-01

    Introducción: las infecciones en las unidades de cuidados intensivos son un problema de salud pública mundial por su incidencia, prevalencia e impacto clínico. El objetivo fue determinar la tendencia de sensibilidad a los antimicrobianos en un periodo de 10 años en una unidad de cuidados intensivos pediátricos. Métodos: estudio de seguimiento de cohorte. Se consideró variable independiente el antimicrobiano utilizado y variable dependiente la sensibilidad antimicrobiana con seguimiento a 10 años. Se comparó la sensibilidad inicial y final, y los diagnósticos más prevalentes y antimicrobianos con chi cuadrada con prueba exacta de Fisher. Se consideró significación estadística con p a dos colas de 0.05. Los datos se analizaron mediante los programas estadísticos SPSS 8 y Epi-Info 0.6 Resultados: la sensibilidad a los antimicrobianos pasó del 66 al 45 % en 10 años, lo cual representó una pérdida global del 13 % (p = 0.002). Los antimicrobianos que más perdieron sensibilidad fueron la cefalosporina de primera generación (p = 0.02), el ciprofloxacino (p = 0.05), la eritromicina (p = 0.001), el imipenem (p = 0.001) y el trimetroprim-sulfametoxasol (p = 0.05). Conclusión: existe una pérdida preocupante de efectividad de los antimicrobianos.

  12. Brachial plexus morphology and vascular supply in the wistar rat.

    PubMed

    Angélica-Almeida, Maria; Casal, Diogo; Mafra, Manuela; Mascarenhas-Lemos, Luís; Martins-Ferreira, José; Ferraz-Oliveira, Mário; Amarante, José; Goyri-O'Neill, João

    2013-01-01

    Introdução: O rato é provavelmente a espécie animal mais utilizada em estudos experimentais de reparação nervosa. Com este trabalho pretendeu-se aprofundar o conhecimento da morfologia e da vascularização do plexo braquial do rato.Material e Métodos: Trinta ratos adultos foram estudados relativamente à morfologia e vascularização do plexo braquial. As técnicas usadas foram a injecção intravascular e dissecção sob microscópio operatório, bem como técnicas de microscopia óptica e microscopia electrónica de varrimento.Resultados: Morfologicamente, o plexo braquial do rato é um pouco diferente do plexo braquial humano. O suprimento arterial e venoso do plexo braquial do rato deriva direta ou indiretamente dos vasos vizinhos. Estes vasos formam plexos vasculares densos e interconectados no epinervo, perinervo e endonervo. Vários componentes do plexo braquial do rato são acompanhados durante um trajecto relativamente longo por vasos sanguíneos relativamente calibrosos e constantes que fornecem o seu plexo epineural, tornando o seu levantamento como retalhos nervosos possível.Discussão: A vascularização do plexo braquial do rato não é muito diferente da reportada na espécie humana, tornando o rato um modelo animal útil para o estudo experimental da fisiopatologia e tratamento da patologia do nervo periférico.Conclusão: Os nossos resultados apoiam a homologia entre o rato e o Homem em termos de morfologia e vascularização do plexo braquial. Este trabalho sugere que vários componentes do plexo braquial do rato podem ser utilizados como retalhos nervosos, incluindo fibras predominantemente motoras, sensitivas ou fibras mistas.

  13. [RELATION BETWEEN THE BODY COMPOSITION AND THE SPORTS PRACTICE IN TEENAGERS].

    PubMed

    Gutiérrez, Rebeca; Aldea, Lourdes; Cavia, María Del Mar; Alonso-Torre, Sara Raquel

    2015-07-01

    Introducción: conocer de forma precisa la composición corporal es importante para evaluar el estado nutricional de los adolescentes para así valorar cómo influye la práctica deportiva en este colectivo. Objetivos: evaluar en un grupo de adolescentes la influencia de la práctica regular de ejercicio físico sobre su composición corporal. Métodos: se evaluaron 77 adolescentes varones entre 12 y 13 años. Se midió: peso, altura, pliegue cutáneo tricipital (PCT), perímetro de la muñeca y del brazo relajado y cintura umbilical. El porcentaje de grasa corporal (%GC) se estimó utilizando diferentes ecuaciones (Siri, Siri modificado, Lohman, Johnston, Deurenberg IMC, porcentaje de grasa a partir del ICT). También se usó un equipo de bioimpedancia eléctrica. Resultados: no se encontraron diferencias significativas en el IMC entre ambos colectivos. La prevalencia de sobrepeso y obesidad varió según las tablas de percentiles utilizadas. Hubo diferencias significativas en el PCT entre ambos grupos, siendo mayor en los no deportistas (p < 0,05), así como en el porcentaje de grasa corporal. No se observaron diferencias significativas entre los valores de grasa corporal obtenidos por las ecuaciones de Siri modificado, Lohman y bioimpedancia en ninguno de los dos colectivos estudiados. Discusión: el %GC fue mayor entre el colectivo de no deportistas, así como el valor de PCT a un mismo valor de IMC. Se determinó que el colectivo deportista obtuvo un mejor estado nutricional que el colectivo no deportista. Independientemente del método utilizado, los resultados deben interpretarse con cautela al evaluar la composición corporal de los adolescentes.

  14. [Proposal of reference values of microbiological environment monitoring in foodservice establishments].

    PubMed

    Soler Quiles, Carla; Mañes, Jordi; Savino, Angelo; Soriano, José M

    2015-04-01

    Introducción: Proponer una nueva referencia microbiológica ambiental en los servicios de restauración. Objetivo: El presente trabajo muestra la determinación y evaluación de la contaminación microbiológica generada en un establecimiento de servicio de alimentos. Método: Se basa en el muestreo microbiológico de superficie utilizando filtros de membrana de ésteres mixtos de celulosa y en el muestreo de aire utilizando placas de Petri. Resultados: Los límites de contaminación se establecieron antes y durante la elaboración de alimentos, mediante el análisis microbiológico de las superficies y del medio ambiente, sistemas de equipos, hasta límites confiables y estableciendo niveles de aceptación en cada punto seleccionado. Por último, se estableció un programa de vigilancia microbiológica del medio ambiente incluyendo la evaluación de todos los parámetros que la componen y están implícitos en la zona, asegurando de esta manera y el apoyo a su continuidad con la documentación y los registros desarrollados para el área de seguridad. Las muestras para el análisis microbiológico se recogieron durante un período durante diez días diferentes, en dos horas diferentes. Se identificaron doce puntos como peligrosos. Además, los alimentos clasificados como de alto riesgo fueron recogidos periódicamente para el análisis microbiológico. Conclusiones: La posibilidad de utilizar de una amplia gama de medios selectivos, muy por encima del número limitado utilizado en este estudio, permite el análisis de muchas especies microbianas individuales.

  15. Memória fonológica em crianças bilíngues bimodais e crianças com implante coclear

    PubMed Central

    de Quadros, Ronice Müller; Cruz, Carina Rebello; Pizzio, Aline Lemos

    2014-01-01

    RESUMO Este estudo comparou o desempenho de crianças bilíngues bimodais ouvintes (filhas de pais surdos) e crianças surdas usuárias de implante coclear (filhas de pais surdos e de pais ouvintes), com diferentes contextos de acesso à Língua Brasileira de Sinais (Libras), em tarefas que envolvem memória fonologica. Os testes utilizados foram: Teste de Pseudopalavras (Santos e Bueno, 2003) e Teste de Pseudosinais (desenvolvido pelos pesquisadores responsáveis pelo Projeto ‘Desenvolvimento Bilíngue Bimoda’). Além disso, foram incluídos dois grupos de controle, formados por crianças surdas (usuarias de Libras), e adultos bilíngues bimodais ouvintes. Na análise dos resultados, em relação ao desempenho entre os dois grupos testados foi constatado que o grupo de crianças bilíngues bimodais ouvintes apresentou desempenho superior, nos dois testes. No entanto, ao ser analisado o desempenho da criança surda usuaria de implante coclear, filha de pais surdos, que possui acesso irrestrito à Libras e comparado com o das crianças surdas usuárias de implante coclear, que possuem acesso restrito à Libras, foi constatado que o seu desempenho foi semelhante ao do grupo de crianças bilíngues bimodais ouvintes. As crianças surdas usuárias de implante coclear com acesso restrito à Libras e, portanto, com acesso maior ao Português apresentaram escores mais baixos nas tarefas, principalmente do teste em Português. Os resultados sugerem que as crianças surdas usuárias de implante coclear em processo de aquisição da línguagem podem se beneficiar com o acesso irrestrito à Libras, atingindo inclusive desempenho semelhante a de crianças bilíngues bimodais ouvintes. PMID:25110473

  16. A distribuição de velocidades na linha de visada em galáxias barradas vistas de face

    NASA Astrophysics Data System (ADS)

    Gadotti, D. A.; de Souza, R. E.

    2003-08-01

    Com o objetivo de realizar um estudo cinemático da componente vertical de barras em galáxias, obtivemos espectros de fenda longa de alta razão S/N ao longo dos eixos maior e menor de 14 galáxias barradas vistas de face, nos telescópios de 1.52m do ESO em La Silla, Chile, e de 2.3m do Steward Observatory em Kitt Peak, Arizona. Estes dados nos permitiram determinar a distribuição de velocidades das estrelas ao longo do eixo vertical das barras e discos destes sistemas, tanto no centro como em pontos que distam cerca de 5 e 20 segundos de arco do núcleo, correspondendo a distâncias de cerca de 0.7 e 2.8 kpc, respectivamente. Desta forma, a variação radial da distribuição de velocidades também pôde ser avaliada. Este tipo de análise tem raros exemplos na literatura por ser caro em termos de tempo de telescópio. Entretanto, é de fácil justificativa, considerando que traz novas informações que podem ser utilizadas para aperfeiçoar modelos teóricos acerca da formação e evolução de galáxias. Um algoritmo por nós desenvolvido foi utilizado para obter as distribuições de velocidades como Gaussianas generalizadas (polinômios de Gauss-Hermite), o que traz um ingrediente a mais neste tipo de estudo que, tradicionalmente, se utiliza de Gaussianas puras, uma hipótese nem sempre razoável. Apresentaremos os resultados deste trabalho, que incluem um diagnóstico para a identificação de barras recém formadas, e testes para o modelo isotérmico de discos. Mostraremos que: (i) a escolha das estrelas padrão em velocidade, e dos parâmetros da Gaussiana, deve ser muito bem justificada já que tem influência significativa nos resultados; (ii) muitas galáxias apresentam uma depressão na dispersão de velocidades na região central, que pode estar associada a um disco interno; e (iii) a dispersão de velocidades é constante ao longo da barra, nos eixos maior e menor, mas cai substancialmente quando se passa da barra para o disco.

  17. PubMed

    Guedes, Gilvan Ramalho; Caetano, André Junqueira; Machado, Carla Jorge; Brondízio, Eduardo Sonewend

    2010-01-01

    O método Grade of Membership (GoM) tem sido cada vez mais utilizado por demógrafos brasileiros e tem a vantagem de possuir um parâmetro que mensura a heterogeneidade individual, com base nas correlações não-observáveis entre as categorias de resposta das variáveis de interesse, gerando um medida do grau de pertencimento de cada indivíduo a perfis extremos. Alguns autores, contudo, chamam atenção para questões importantes na calibragem dos modelos finais que utilizam o programa GoM versão 3.4, como o problema de identificabilidade - soluções múltiplas para parâmetros estimados. Neste artigo, é sugerido um procedimento capaz de identificar um modelo final com solução única que descreva os tipos puros mais fidedignos à base de dados, em uma tentativa de otimização. Para ilustrar esse processo, utilizou-se uma base de dados correspondente a um levantamento econômico e sociodemográfico de uma população de pequenos agricultores residentes ao longo da Rodovia Transamazônica, no Estado do Pará. Também identificou-se a existência de instabilidade nos parâmetros estimados pelo programa GoM 3.4, sendo proposto um método de estabilização de seus valores. Com esses procedimentos combinados, os usuários do programa GoM 3.4 poderão descrever sua base de dados de forma mais adequada e responder às críticas sobre questões de identificabilidade e estabilidade dos modelos resultantes. Essas soluções empíricas são relevantes por afetarem cálculos de prevalência e de incidência de eventos de interesse, além de trazerem consequências importantes sobre o ponto e o momento corretos para intervenções de políticas públicas ou de planejamento prospectivo em análises de projeção.

  18. PubMed

    Guedes, Gilvan Ramalho; Caetano, André Junqueira; Machado, Carla Jorge; Brondízio, Eduardo Sonewend

    2010-01-01

    O método Grade of Membership (GoM) tem sido cada vez mais utilizado por demógrafos brasileiros e tem a vantagem de possuir um parâmetro que mensura a heterogeneidade individual, com base nas correlações não-observáveis entre as categorias de resposta das variáveis de interesse, gerando um medida do grau de pertencimento de cada indivíduo a perfis extremos. Alguns autores, contudo, chamam atenção para questões importantes na calibragem dos modelos finais que utilizam o programa GoM versão 3.4, como o problema de identificabilidade - soluções múltiplas para parâmetros estimados. Neste artigo, é sugerido um procedimento capaz de identificar um modelo final com solução única que descreva os tipos puros mais fidedignos à base de dados, em uma tentativa de otimização. Para ilustrar esse processo, utilizou-se uma base de dados correspondente a um levantamento econômico e sociodemográfico de uma população de pequenos agricultores residentes ao longo da Rodovia Transamazônica, no Estado do Pará. Também identificou-se a existência de instabilidade nos parâmetros estimados pelo programa GoM 3.4, sendo proposto um método de estabilização de seus valores. Com esses procedimentos combinados, os usuários do programa GoM 3.4 poderão descrever sua base de dados de forma mais adequada e responder às críticas sobre questões de identificabilidade e estabilidade dos modelos resultantes. Essas soluções empíricas são relevantes por afetarem cálculos de prevalência e de incidência de eventos de interesse, além de trazerem consequências importantes sobre o ponto e o momento corretos para intervenções de políticas públicas ou de planejamento prospectivo em análises de projeção. PMID:21709732

  19. [Adaptation and validation of CAMDEX-DS (Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and others with intellectual disabilities) in Spanish population with intellectual disabilities].

    PubMed

    Esteba-Castillo, Susanna; Dalmau-Bueno, Albert; Ribas-Vidal, Núria; Vilà-Alsina, Marta; Novell-Alsina, Ramon; García-Alba, Javier

    2013-10-16

    Introduccion. La demencia causada por la enfermedad de Alzheimer afecta comunmente a la poblacion adulta con sindrome de Down. Esta poblacion presenta dos rasgos clinicos caracteristicos: la presencia de demencia con semiologia distinta a la enfermedad de Alzheimer tipica y deficits intelectuales previos que pueden confundir el diagnostico clinico. Existe una evidente necesidad de validar instrumentos especificos en castellano adaptados a esta poblacion. Objetivo. Adaptar y validar el Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS) en poblacion española. Pacientes y metodos. Se consideraron 146 pacientes con discapacidad intelectual (leve-moderada). Se realizo un estudio de validacion de tipo observacional, transversal y multicentrico. Se administraron los siguientes tests: CAMDEX-DS, test breve de inteligencia de Kaufman y Dementia Questionnaire for Persons with Mental Retardation. Se calculo la fiabilidad test-retest, la fiabilidad interjueces, la concordancia del CAMDEX-DS para el diagnostico clinico y la validez. Resultados. La fiabilidad test-retest e interjueces obtuvo un coeficiente kappa de 0,92 y 0,91, respectivamente. El indice kappa del CAMDEX-DS para el diagnostico clinico respecto al resto de los criterios clinicos utilizados fue alto: CAMDEX-DS frente a DSM-IV (kappa = 0,95; p < 0,001); CAMDEX-DS frente a Clasificacion Internacional de Enfermedades, decima revision (kappa = 0,97; p = 0,000). Todas las correlaciones item-test oscilaban entre 0,31 y 0,69. La fiabilidad interna calculada mediante el alfa de Cronbach fue de 0,93. Conclusiones. La version española del CAMDEX-DS es un instrumento valido, de alta aplicabilidad a personas con discapacidad intelectual, que muestra buenas propiedades psicometricas. El Cambridge Cognitive Examination for Older Adults with Down's Syndrome (CAMCOG-DS) permite establecer dos puntos de corte para la sospecha de deterioro

  20. [Not Available].

    PubMed

    Villa-González, Emilio; Rodríguez-López, Carlos; Barranco-Ruiz, Yaira; Cabezas-Arévalo, Luis Fabián; Chillón, Palma

    2016-06-30

    Objetivo: analizar la concordancia de dos métodos de medición (Google MapsTM vs. Sistema de Información Geográfica) para la determinación de la distancia desde el domicilio familiar hasta el colegio.Métodos: un total de 542 escolares de entre 8-11 años de edad (media = 9,36 ± 0,6) del sur de España participaron en el estudio, facilitando la dirección de su domicilio familiar. La distancia desde el domicilio familiar al colegio se calculó mediante la utilización de dos programas diferentes:Google MapsTM y Sistema de Información Geográfica (GIS) en ruta y en línea recta. La asociación entre ambos métodos fue analizada utilizando la correlación de Spearman y el grado de acuerdo a través del coeficiente de correlación intraclase (ICC), así como el método Bland Altman.Resultados: la correlación entre ambos métodos de medición propuestos fue muy significativa (r = 0,966, p < 0,001; r = 0,984, p < 0,001; y r = 0,954, p < 0,001, respectivamente), y la concordancia fue excelente (ICC = 0,96, p < 0,001; ICC = 0,92, p < 0,001; ICC = 0,97, p < 0,001).Conclusiones: los métodos de medición estudiados podrían ser utilizados en función de las necesidades de la investigación, al presentar ambos una alta concordancia. Sin embargo, se recomienda la utilización del Sistema de Información Geográfica en ruta si se cuenta con medios yfinanciación, por tratarse de un método constatado en fiabilidad y validez.

  1. [Not Available].

    PubMed

    Villa-González, Emilio; Rodríguez-López, Carlos; Barranco-Ruiz, Yaira; Cabezas-Arévalo, Luis Fabián; Chillón, Palma

    2016-01-01

    Objetivo: analizar la concordancia de dos métodos de medición (Google MapsTM vs. Sistema de Información Geográfica) para la determinación de la distancia desde el domicilio familiar hasta el colegio.Métodos: un total de 542 escolares de entre 8-11 años de edad (media = 9,36 ± 0,6) del sur de España participaron en el estudio, facilitando la dirección de su domicilio familiar. La distancia desde el domicilio familiar al colegio se calculó mediante la utilización de dos programas diferentes:Google MapsTM y Sistema de Información Geográfica (GIS) en ruta y en línea recta. La asociación entre ambos métodos fue analizada utilizando la correlación de Spearman y el grado de acuerdo a través del coeficiente de correlación intraclase (ICC), así como el método Bland Altman.Resultados: la correlación entre ambos métodos de medición propuestos fue muy significativa (r = 0,966, p < 0,001; r = 0,984, p < 0,001; y r = 0,954, p < 0,001, respectivamente), y la concordancia fue excelente (ICC = 0,96, p < 0,001; ICC = 0,92, p < 0,001; ICC = 0,97, p < 0,001).Conclusiones: los métodos de medición estudiados podrían ser utilizados en función de las necesidades de la investigación, al presentar ambos una alta concordancia. Sin embargo, se recomienda la utilización del Sistema de Información Geográfica en ruta si se cuenta con medios yfinanciación, por tratarse de un método constatado en fiabilidad y validez. PMID:27513510

  2. Rotação do jato em DG tau próximo à região de sua formação: análise comparativa das velocidades radiais simuladas e observadas

    NASA Astrophysics Data System (ADS)

    Cerqueira, A. H.; de Gouveia dal Pino, E. M.

    2003-08-01

    Os modelos magneto-centrífugos utilizados para explicar a formação dos jatos Herbig-Haro assumem a presença de um disco de acresção em rotação kepleriana na base de lançamento do jato. Neste cenário, o jato transmite a informação da rotação do disco para regiões distantes da fonte central, além da superfície de Alfvén, na região de colimação inicial do jato. Recentemente, Bacciotti et al. (2002, ApJ, 537, L49) obtiveram pela primeira vez uma evidência observacional de rotação em um jato HH, o jato em DG Tau, em regiões próximas da fonte central, compatível (qualitativa e quantitativamente) com o esperado a partir dos modelos magneto-centrífugos para a produção e colimação inicial de jatos HH. No presente trabalho, apresentamos mapas de velocidade radial, obtidos através de simulações numéricas tri-dimensionais SPH, para um jato com características semelhantes ao jato em DG Tau, objetivando uma comparação com os mapas de velocidade radiais obtidos por Bacciotti et al.. Nossos resultados, embora preliminares, indicam que a inclusão de efeitos como a precessão, evidenciada em DG Tau (Dougados et al. 2000, A&A, 357, L61) devem ser levadas em consideração na análise da presença de rotação não só em DG Tau mas em qualquer sistema, com o uso das velocidades radias observadas. A ausência de um grau elevado de simetria axial (quebrada, por exemplo, pela precessão do eixo do jato; ou pela presença de uma superfície interna de trabalho, ou seja, um bow shock interno), implica também em uma maior complexidade nos mapas, com conseqüências relevantes para suas interpretações.

  3. Development of Educational Resources to Include the Teaching of Astronomy in the First Years of the Basic Education. (Spanish Title: Desarrollo de Recursos Pedagógicos Para Incluir la Enseñanza de la Astronomía en los Primeros Años de la Educación Básica.) Desenvolvimento de Recursos Pedagógicos Para Inserir o Ensino de Astronomia nas Séries Iniciais do Ensino Fundamental

    NASA Astrophysics Data System (ADS)

    da Silva Morett, Samara; de Oliveira Souza, Marcelo

    2010-07-01

    ía y la vida cotidiana de los estudiantes. La inclusión de la astronomía en la escuela primaria es una manera de demostrar a los estudiantes cómo este campo está presente de forma activa en su vida cotidiana. Las clases que participan en el proyecto participaron en un estudio con el objetivo de proporcionar información a los conocimientos previos que tenían sobre los temas de la astronomía que se examinaron durante el proyecto. Con los experimentos realizados, y la ayuda de las nuevas tecnologías, conceptos astronómicos fueron presentados a los estudiantes de 4to y 5to año de la educación básica de una escuela municipal de Campos dos Goytacazes (RJ). Después de las presentaciones nuevos datos fueran colectados y se han llevado a cabo con el fin de verificar el nivel de aprendizaje alcanzado y se observó que el método utilizado fue una herramienta importante para ayudar al proceso de enseñanza y aprendizaje. El proyecto logró resultados satisfactorios. Neste trabalho será apresentado o desenvolvimento de recursos pedagógicos para a apresentação de conceitos de astronomia nas séries iniciais do ensino fundamental. Este material é composto por apresentações realizadas com o uso de novos recursos tecnológicos, pela fabricação de experimentos e a discussão de curiosidades relativas a esta área de conhecimento. Os experimentos foram construídos com material de baixo custo com o objetivo de permitir que os alunos envolvidos pudessem refazê-los em outras ocasiões. O material apresentado busca enfatizar a relação entre a astronomia e o cotidiano dos alunos. A inclusão da astronomia no ensino fundamental e uma forma de demonstrar aoestudante como esta área está presente de forma ativa em seu cotidiano. As turmas envolvidas no projeto participaram de uma pesquisa com o objetivo de obter dados relativos ao conhecimento prévio que possuíam sobre os tópicos de astronomia que foram considerados no decorrer do projeto. Com os experimentos

  4. A Diagnostic Assessment for the Teaching of Astronomy. (Spanish Title: Una Evaluación Diagnóstica Para la Enseñanza de la Astronomia.) Uma Avaliação Diagnóstica Para o Ensino da Astronomia

    NASA Astrophysics Data System (ADS)

    Pacifico Ribeiro de Assis Silveira, Felipa; Soares Gomes de Sousa, Célia Maria; Moreira, Antonio

    2011-07-01

    interpretación, lo que nos permite comprender los significados asignados por el estudiante a estos conceptos. Se desprende de la evaluación diagnóstica que la mayoría de los encuestados ha tenido dificultades para exponer los conceptos científicos sobre el Universo y la Tierra, para iniciar el 6 º grado. Sin embargo, se identificaron ideas relevantes y las representaciones que contribuyeron a la re-significación de los conceptos científicos propuestos para la enseñanza del tema en esta serie. Los resultados de la evaluación diagnóstica han servido como referencia para la organización del Programa, facilitando el proceso de aprendizaje, haciendo coincidir la secuencia didáctica a las características de los estudiantes y el contexto del aula. Se espera que el instrumento presentado en este documento también pueda ser utilizado por otros investigadores en investigaciones relacionadas con el tema. Este artigo tem como objetivo apresentar os resultados de uma avaliação diagnóstica, utilizada como instrumento para a coleta de dados sobre o conhecimento prévio de conceitos científicos, necessários à compreensão do tema Terra e Universo, de um grupo composto por 47 estudantes, da 6ª série do Ensino Fundamental. A ação pedagógica de diagnosticar os conhecimentos prévios, do estudante, antes de ensiná-los, tem fundamento na teoria da Aprendizagem Significativa, proposta por David Ausubel. Essa avaliação diagnóstica foi composta por 25 questões, cujas respostas foram analisadas e categorizadas visando sua interpretação, o que permitiu compreender os significados atribuídos pelo estudante a esses conceitos. Conclui-se, a partir da avaliação diagnóstica, que a maioria dos estudantes pesquisados apresentou dificuldades em expor conceitos científicos sobre o tema Terra e Universo ao iniciar a 6ª série. Entretanto, foram identificadas ideias e representações relevantes que contribuíram para a (re)significação dos conceitos científicos propostos

  5. Populações estelares do bojo galáctico

    NASA Astrophysics Data System (ADS)

    Escudero, A. V.; Costa, R. D. D.; Maciel, W. J.

    2003-08-01

    Os estudos mais recentes do bojo galáctico têm enfocado essencialmente as abundâncias químicas de elementos pesados, como o ferro, obtidos a partir das estrelas nas regiões centrais da galáxia. Elementos leves, como hélio, nitrogênio, oxigênio e argônio ainda são pouco estudados nestas regiões, devido à difícil determinação de suas abundâncias a partir de estrelas. Nestas condições as nebulosas planetárias desempenham um importante papel, pois permitem a determinação de abundâncias destes elementos usando técnicas de espectroscopia nebular. Neste trabalho, reportamos a análise das abundâncias químicas de uma nova amostra de nebulosas planetárias do bojo, bem como os resultados preliminares de um código numérico destinado a modelar a evolução química desta região. Usamos como vínculos observacionais os resultados obtidos das nebulosas planetárias, bem como de abundâncias estelares da região do bojo, obtidas da literatura. A partir deste modelo da evolução química e dos vínculos observacionais foi possível fazer um diagnóstico mais preciso das populações que constituem o bojo galáctico. O estudo destas populações que compõem a região central de nossa galáxia é de extrema importância para o maior entendimento da evolução química e dinâmica da galáxia como um todo. Por isto, verificamos a importância dos modelos de formação simples e mista utilizados para explicar características da população da região central da galáxia. Algumas destas características são: uma grande dispersão nos valores das abundâncias químicas e um grande espalhamento nas correlações entre as abundâcias de nitrogênio e oxigênio. Estas peculiaridades são dificilmente reproduzidas por modelos de formação simples, e portanto são importantes indícios da validade dos modelos de formação mista, tais como um rápido colapso do bojo seguido de uma evolução secular. (FAPESP, CNPq)

  6. Chemotherapy near the end of life; assessment of the clinical practise in onco-hematological in adult patients.

    PubMed

    Taberner Bonastre, Pilar; Taberner Bonastre, María Teresa; Soler Company, Enrique; Pérez-Serrano Lainosa, María Dolores

    2016-01-01

    Objetivo: garantizar una buena calidad de vida en la última fase de los pacientes onco-hematológicos debería ser nuestro principal objetivo; a pesar de ello, disponemos de pocos datos a nivel europeo y los estudios publicados son contradictorios. No obstante, la mayoría coinciden en que administrar quimioterapia en la etapa final de la vida impacta de forma negativa en la calidad de vida del paciente. El objetivo principal del estudio es analizar los indicadores de no agresividad del tratamiento en pacientes onco-hematológicos. Como objetivo secundario, realizar un estudio descriptivo de las variables clínicas de los pacientes a los que se les administra quimioterapia en la fase final de la vida y los esquemas más utilizados. Método: se realizó un estudio observacional retrospectivo en un hospital de tercer nivel. Se incluyeron todos los pacientes oncológicos y hematológicos que recibieron quimioterapia (oral o intravenosa) entre enero y diciembre de 2013, a los que se les administró la última quimioterapia en los 90 días previos al fallecimiento. Resultados: se analizaron 823 pacientes que recibieron tratamiento entre enero y diciembre de 2013. De ellos, 106 (13%) cumplían los criterios de inclusión. Un 14,1% (n = 93) de los pacientes oncológicos y un 8,4% (n = 13) de los hematológicos que habían recibido quimioterapia durante el último año de vida lo seguían haciendo en los últimos tres meses. Un 21,7% (n = 23) de los pacientes recibieron quimioterapia en las dos últimas semanas, 41,5% (n = 44) en los últimos 30 días y 78,3% (n = 83) en los últimos dos meses de vida. El 67,9% (n = 72) de los pacientes ingresaron en el hospital durante los últimos tres meses de vida, el 47,2% (n = 50) lo hicieron durante el último mes, el 33% (n = 35) durante las dos últimas semanas y el 10,4% (n = 11) durante los últimos tres días de vida. El 25,5% (n = 27) de los pacientes ingresaron en más de una ocasión durante los 90 días previos al

  7. Abundâncias químicas de estrelas T Tauri fracas

    NASA Astrophysics Data System (ADS)

    Rojas, G. A.; Gregorio-Hetem, J.

    2003-08-01

    Apresentamos resultados do estudo de 44 estrelas pré-seqüência principal, para as quais buscamos realizar uma classificação espectroscópica e determinar parâmetros estelares e abundâncias químicas. A amostra foi escolhida da seguinte maneira : 21 objetos selecionados a partir de catálogos de objetos jovens, como o Pico dos Dias Survey e o Herbig Bell Catalogue, e 23 objetos selecionados a partir de contrapartidas ópticas de fontes de raios X detectadas pelo satélite ROSAT. Dentre 24 objetos previamente classificados como estrelas T Tauri Fracas, apenas 7 revelaram ser realmente pertencentes à essa classe, sendo os demais objetos T Tauri Clássicas ou estrelas evoluídas da pré-seqüência principal. Esse resultado demonstra que o critério mais utilizado para distinguir as T Tauri Clássicas das T Tauri Fracas, baseado na largura equivelente da emissão Ha, não é suficiente para determinar o estágio evolutivo desses objetos. Para o cálculo de parâmetros estelares e abundâncias, foram escolhidas as estrelas que apresentam características ideais para esse tipo de estudo, como ausência de velamento, baixa velocidade de rotação e espectros com razão sinal-ruído adequada. Os parâmetros estelares como temperatura efetiva e gravidade foram determinados através do equilíbrio de excitação e ionização das linhas de Ferro, e as abundâncias químicas foram calculadas utilizando o método de síntese espectral. Serão apresentados os parâmetros estelares e as abundâncias de Lítio para toda a amostra, e abundâncias de vários elementos quimicos para 7 estrelas estudadas em maior detalhe

  8. [Presentation of the anatomical and clinical method of direct faciometrics in children with preliminary clinical objectives].

    PubMed

    Furtado, Ivo A; Agostinho, Helena Roque

    2014-01-01

    Introdução: Introduzimos o conceito de faciometria directa propedêutica, subjacente ao método de avaliação do crescimento da face infantil apresentado, com relevantes vantagens sobre outros métodos utilizados. Material e Métodos: Observámos 102 crianças Caucasianas saudáveis, de ambos os sexos, até aos 14 anos (inclusive), que acederam à Consulta de Estomatologia Pediátrica do Centro Hospitalar de Lisboa-Norte, desde 1 de Maio de 2011 e durante um ano. Avaliámos o grau de crescimento facial e as suas características, baseados em medidas lineares e angulares obtidas a partir de pontos de referência situados na superfície da face. Realizámos registos sistemáticos de frente e perfil; tomámos medidas lineares com paquímetro digital e angulares com goniómetro digital. Usámos o método estatístico de aplicação de tabelas de correlação e do teste de ANOVA a dois factores. Resultados: Apresentamos resultados e construímos curvas de crescimento. Discussão: Verificámos haver um surto de crescimento ântero-posterior da face até aos 6 anos, que prossegue atenuado até aos nove anos. Dos 9 aos 12 anos verificou-se novo surto de crescimento, residual a partir desta idade. Não houve variações significativas nos valores médios etários angulares, nem diferenças de género no crescimento facial. O erro inter-observador foi de 0,62 mm para valores lineares e 2,65 graus para valores angulares. Conclusões: Método fiável, sem imagem nem radiação, não invasivo, simples, económico e reprodutível. Recomendamos para utilização em Estomatologia Pediátrica e Pediatria, por constituir um recurso propedêutico que permite efectuar diagnóstico precoce de anomalias do crescimento facial da criança, susceptíveis de intercepção e correcção atempadas.

  9. Astronomía Gamma desde El Leoncito

    NASA Astrophysics Data System (ADS)

    Rovero, A. C.; Colombo, E.; Sahade, J.; Weekes, T. C.

    La astronomía gamma, en el extremo de energías detectadas hasta el presente, se encuentra en desarrollo en muchas partes del mundo y proporciona resultados sorprendentes a medida que la tecnología avanza en el desarrollo de nuevos detectores. La técnica Cherenkov Atmosférica es la utilizada para la detección, mediante telescopios en tierra, del efecto secundario causado por la radiación gamma de muy altas energías (E ≈ TeV). Por medio de telescopios o arreglos de detectores y utilizando la técnica mencionada, se han podido detectar algunas fuentes puntuales de mucha importancia astrofísica como la Nebulosa del Cangrejo y la galaxia de núcleo activo Markarian 421. El sistema instalado en San Juan, en cooperación con el grupo de Radiación Gamma del Observatorio Whipple, está constituído por tres colectores de 1.5m que registran pulsos de luz generados por las cascadas de partículas producidas por rayos cósmicos de todo tipo al entrar en la atmósfera terrestre. El sistema opera por barrido en ascención recta de la fuente observada que, para esta etapa del experimento, es el Centro Galáctico. Esta fuente extensa es conocida como emisor gamma de energías inferiores al TeV y ha sido observada anteriormente en este rango de energía desde el hemisferio norte pero con elevaciones bajas, situación no óptima para este tipo de técnica. Se presentan los primeros resultados del análisis de los datos obtenidos observando la región del Centro Galáctico, luego de dos años de observaciones, así como una descripción de la técnica Cherenkov Atmosférica y del equipo utilizado en la experiencia.

  10. [Figures performance of glycemia in type 2 diabetic patients with intake of two breakfast with the same amount of carbohydrates].

    PubMed

    Rueda Páez, Elsy Victoria; Maldonado Obando, Yohanna del Carmen; Caballero Pérez, Luz Alba

    2015-04-01

    Los carbohidratos (CHO) simples en el riesgo cardiometabólico, conllevan al incremento de la glucemia y los niveles de insulina y, a largo plazo a Diabetes Mellitus tipo 2 (DM2). OBJETIVO: determinar el comportamiento de cifras de glucemia en pacientes DM2 con la ingesta de dos desayunos. METODOLOGÍA: Se valoraron por antropometría, bioquímica y clínica 14 pacientes con DM2 a quienes se les administró 2 desayunos en tiempos diferentes con 50 g de CHO representados en galleta tipo dulce y pan blanco. RESULTADOS: se evidenció alteración en el 92,8% de colesterol de baja Densidad (Ldlc), Colesterol Total (CT) y Colesterol de alta densidad (Hdlc) en el 50% y triacilglicerol (TG) en un 35,7%. El comportamiento de la glucemia para el desayuno con galleta no presentó diferencia significativa en la cifra preprandial y postprandial a las 2 y 3 horas (p= 0,051 y 0,054 respectivamente) la glucemia de las 2 horas con las 3 horas mostraron significancia (p=0,012). En el desayuno con pan blanco la glucemia preprandial y postprandial a las 2 horas aumentó (p= 0,006), en tanto, que a las 3 horas, la cifra reportada entre las 2 y 3 horas no presentaron diferencias significativas ( p= 0,114 y 0,051 respectivamente). Al comparar cada una de las glucemias de los desayunos en los periodos preprandial a las 2 y 3 horas no se encontraron diferencias estadísticamente significativas (p>0,05). CONCLUSIÓN: cantidades isocalóricas de carbohidratos de 2 desayunos ingeridos en días diferentes se comportaron de igual manera en las cifras de glucemia. El desayuno con galleta favorecería a la población diabética por los ingredientes utilizados en su elaboración dada su dislipidemia.

  11. [In Process Citation].

    PubMed

    López-Fuenzalida, Antonio; Rodríguez Canales, Carolina; Reyes Ponce, Álvaro; Contreras Molina, Ángela; Fernández Quezada, Javiera; Aguirre Polanco, Carolina

    2016-03-25

    Introducción: dado el incremento del sobrepeso y obesidad infantil, es relevante estudiar no solo las consecuencias metabólicas, sino también aquellas de índole musculoesqueléticas que pueden afectar la funcionalidad motriz, como es el pie plano, en esta población. Objetivo: identificar la asociación entre el estado nutricional y la prevalencia de pie plano en niños y niñas chilenos de 6 a 10 años. Métodos: el z-score del índice de masa corporal (IMC) y el registro y análisis de las huellas plantares según la metodología de Hernández-Corvo fue llevado a cabo en 388 escolares (52,3% niñas). Un test de diferencia para dos proporciones fue utilizado para evaluar las diferencias entre los grupos. Se considera una significancia estadística con p ≤ 0,05. Resultados: la prevalencia del exceso de peso fue de más del 40%. Esta prevalencia fue más alta en las niñas (47,8%) que en los niños (42,7%). La prevalencia de pie plano en todos los niños fue del 17%, presentando valores más elevados el pie derecho (18,3%) que el izquierdo (15,7%). Hay un incremento significativo de la prevalencia de pie plano en los niños obesos en relación con los niños con sobrepeso y normopeso. Conclusión: el estado nutricional está asociado con incrementos en la prevalencia de pie plano en niños. En la población infantil de 6 a 10 años de edad, la obesidad está asociada con la alteración morfológica del pie.

  12. VALIDATION OF A QUESTIONNAIRE TO MEASURE OVERALL MEDITERRANEAN LIFESTYLE HABITS FOR RESEARCH APPLICATION: THE MEDITERRANEAN LIFESTYLE INDEX (MEDLIFE).

    PubMed

    Sotos-Prieto, Mercedes; Santos-Beneit, Gloria; Bodega, Patricia; Pocock, Stuart; Mattei, Josiemer; Peñalvo, Jose Luis

    2015-09-01

    Antecedentes: el índice de estilo de vida mediterráneo (MEDLIFE) fue desarrollado como un cuestionario para recoger la adherencia a un estilo de vida saludable mediterráneo. La fiabilidad del MEDLIFE como cuestionario independiente debe ser evaluada antes de su uso en estudios de investigación. Objetivo: evaluar la fiabilidad inter-método del MEDLIFE como herramienta de investigación corta e independiente. Diseño: cuestionario corto del MEDLIFE de 28 ítems y un cuestionario largo validado de 142 ítems, del cual se derivó posteriormente el cuestionario del MEDLIFE de 28 ítems (MEDLIFE-derivado), se administraron simultáneamente a 196 adultos (edad media 41,4 ± 9,2 años) con residencia en Madrid, España. La fiabilidad se evaluó mediante el coeficiente kappa de Cohen, el coeficiente de correlación intraclase (CCI) y el límite de acuerdo (LOA). Resultados: el grado de correlación entre los dos instrumentos fue 0,626. El MEDLIFE tuvo una capacidad aceptable para clasificar a los participantes mediante el MEDLIFE-derivado (ICC = 0,544). El grado de acuerdo absoluto (coeficiente kappa) mostró muy buena concordancia para el 10,7% de los ítems evaluados; de buena a moderada para la mayoría de los ítems, y razonable para el 32,1% de los ítems. La ingesta de dulces, carnes procesadas, productos lácteos bajos en grasa y cereales se sobreestimó por el MEDLIFE. El 38%, 15%, 12% y 10% de los participantes que obtuvieron 1 punto para esos ítems en el MEDLIFE también obtuvieron 1 punto en el MEDLIFE-derivado, respectivamente. El análisis de Bland Altman mostró un rango de LOA de -4,66 a 7,45 (media = 1,40). Conclusión: el MEDLIFE es un instrumento válido para medir la adherencia global al estilo de vida mediterráneo en adultos de mediana edad de una población española, y podría ser utilizado como cuestionario independiente en estudios clínicos y epidemiológicos para tal población. Su generalización y validez predictiva para los parámetros cl

  13. Manual del McVCO 1999

    USGS Publications Warehouse

    McChesney, P.J.

    1999-01-01

    El McVCO es un generador de frecuencias basado en un microcontrolador que reemplaza al oscilador controlado por voltaje (VCO) utilizado en telemetría analógica de datos sísmicas. Acepta señales de baja potencia desde un sismómetro y produce una señal subportadora modulada en frecuencia adecuada para enlaces telefónicos o vía radio a un lugar remoto de recolección de datos. La frecuencia de la subportadora y la ganancia pueden ser seleccionadas mediante un interruptor. Tiene la opción de poder operar con dos canales para la observación con ganancia alta y baja. El McVCO fue diseñado con el propósito de mejorar la telemetría analógica de las señales dentro de la Pacific Northwest Seismograph Network (PNSN) (Red Sismográfica del Noroeste del Pacífico). Su desarrollo recibió el respaldo del Programa de Geofísica de la Universidad de Washington y del "Volcano Hazards and Earthquake Hazards programs of the United States Geological Survey (USGS) (Programa de Investigaciones de Riesgos Volcánicos y Programa de Investigaciones de Riesgos Sísmicos de los EEUU). Cientos de instrumentos se han construido e instalado. Además de utilizarlo el PNSN, el McVCO es usado por el Observatorio Vulcanológico de Alaska para monitorear los volcanes aleutianos y por el USGS Volcano Disaster Assistance Program (Programa de Ayuda en las Catástrofes Volcánicas del USGS) para responder a crisis volcánicas en otros países. Este manual cubre el funcionamiento del McVCO, es una referencia técnica para aquellos que necesitan saber con más detalle cómo funciona el McVCO, y cubre una serie de temas que requieren un trato explícito o que derivan del despliegue del instrumento.

  14. BLOOD PRESSURE IN HYPERTENSIVE WOMEN AFTER AEROBICS AND HYDROGYMNASTICS SESSIONS.

    PubMed

    Loiola Souto, Adriana; Moreira Lima, Luciana; Aparecida Castro, Eliane; Peixoto Veras, Renato; Segheto, Wellington; Camargos Zanatta, Thaís; Aparecida Doimo, Leonice

    2015-08-01

    Introducción: la práctica regular de ejercicios ha sido recomendada como conducta importante en el control de la presión arterial. En los últimos años se ha demostrado que una sola sesión de ejercicio físico puede disminuir la presión arterial comparada a los niveles del periodo pre-ejercicio, convirtiéndose en una terapia no farmacológica efectiva para el tratamiento de la hipertensión. Objetivo: analizar el comportamiento de la presión arterial post-ejercicio en mujeres hipertensas controladas tras la realización de una sesión de gimnasia acuática y una sesión de gimnasia aeróbica. Métodos: participaron en el estudio 12 mujeres mayores con edad de 65 ± 3.6 años y practicantes de actividad física por un periodo superior a dos meses. La presión arterial fue medida durante 60 minutos tras el final de cada clase. Este procedimiento fue realizado cada 5 minutos tras el esfuerzo hasta el vigésimo minuto de la recuperación, seguido de mediciones cada 10 minutos hasta el sexagésimo minuto. Fue utilizado el test T-Student para la comparación de los promedios y fue adoptado un nivel de significación del 5%. Resultados: los promedios de hipotensión encontrados durante la recuperación tras la clase de gimnasia acuática no fueron significativamente diferentes comparados con los promedios obtenidos en el pre-ejercicio (p = 0,260). Sin embargo, en la sesión de gimnasia aeróbica la diferencia entre esos valores fue estadísticamente significativa (p < 0,001). Los menores valores de presión arterial sistólica alcanzados en la recuperación para gimnasia acuática (120 mmHg) y gimnasia aeróbica (106 mmHg) también fueron significativamente diferentes (p < 0,001). Conclusión: la gimnasia aeróbica se mostró más eficiente para la reducción de la presión arterial post-ejercicio con respecto a la gimnasia acuática, presentando menores valores y mayor duración del efecto hipotensor.

  15. Simulação de ejeções de massa coronal

    NASA Astrophysics Data System (ADS)

    Corsini, M. A.; Silva, A. V. R.

    2003-08-01

    Ejeções de massa coronal (EMC) são bolhas gigantes de gás permeadas por campos magnéticos que são ejetadas do Sol durante um período de várias horas. Caso estas ejeções atinjam a Terra, geralmente, causam uma série de distúrbios às comunicações de longa distância e navegação, além de danos a satélites e transformadores. Portanto, é desejável que sejamos capazes de prever quando estas ejeções atingirão a Terra. Para tanto, é necessário um bom entendimento dos mecanismos causadores das ejeções e, principalmente, de como se dá a propagação das EMC e sua interação com o vento solar que permeia o meio interplanetário. Nesse sentido foi desenvolvido um programa computacional para resolver as equações MHD (Magneto-Hidro-Dinâmica) que regem a evolução das EMC. Primeiramente foram estabelecidas as condições necessárias para descrever o vento solar, no estado estacionário, que permeia todo o meio interplanetário. Num primeiro momento, resolveu-se o sistema de equações para o caso do vento isotérmico, conhecida como a solução de Parker, a fim de testarmos o modelo. Então, foi considerado o caso do vento solar com temperatura variável no meio interplanetário. Este resultado foi utilizado como a base de nosso sistema em seu instante inicial. Posteriormente foram feitas as considerações necessárias para descrever a propagação da Ejeção de Massa Coronal. As EMC foram simuladas como um aumento de densidade e temperatura local na coroa solar. A órbita e a posição da Terra foram incluídas no sistema. Os dados gerados possibilitaram uma análise da evolução da EMC pelo meio interplanetário até encontrar-se com a Terra. Os perfis de densidade e temperatura a 1 Unidade Astronômica são comparados com os dados de satélites reportados na literatura.

  16. [In Process Citation].

    PubMed

    López-Fuenzalida, Antonio; Rodríguez Canales, Carolina; Reyes Ponce, Álvaro; Contreras Molina, Ángela; Fernández Quezada, Javiera; Aguirre Polanco, Carolina

    2016-01-01

    Introducción: dado el incremento del sobrepeso y obesidad infantil, es relevante estudiar no solo las consecuencias metabólicas, sino también aquellas de índole musculoesqueléticas que pueden afectar la funcionalidad motriz, como es el pie plano, en esta población. Objetivo: identificar la asociación entre el estado nutricional y la prevalencia de pie plano en niños y niñas chilenos de 6 a 10 años. Métodos: el z-score del índice de masa corporal (IMC) y el registro y análisis de las huellas plantares según la metodología de Hernández-Corvo fue llevado a cabo en 388 escolares (52,3% niñas). Un test de diferencia para dos proporciones fue utilizado para evaluar las diferencias entre los grupos. Se considera una significancia estadística con p ≤ 0,05. Resultados: la prevalencia del exceso de peso fue de más del 40%. Esta prevalencia fue más alta en las niñas (47,8%) que en los niños (42,7%). La prevalencia de pie plano en todos los niños fue del 17%, presentando valores más elevados el pie derecho (18,3%) que el izquierdo (15,7%). Hay un incremento significativo de la prevalencia de pie plano en los niños obesos en relación con los niños con sobrepeso y normopeso. Conclusión: el estado nutricional está asociado con incrementos en la prevalencia de pie plano en niños. En la población infantil de 6 a 10 años de edad, la obesidad está asociada con la alteración morfológica del pie. PMID:27238781

  17. [Evaluation of technical skills in surgical training].

    PubMed

    Kasparian, Andres C; Martinez, A C; JoverClos, R J; Chércoles, R A

    2014-01-01

    Introducción: La adquisición de habilidades quirúrgicas constituye un factor central en la formación de todo cirujano. Sin embargo, la evaluación de las habilidades técnicas es uno de los factores más débiles y menos desarrollados. En la actualidad los recursos para evaluar las competencias técnicas adolecen de subjetividad, falta de confiabilidad y validez. La observación directa, método de evaluación más frecuentemente utilizado en nuestro medio, presenta inconvenientes instrumentales y está fuertemente influenciada por las relaciones intersubjetivas y los rasgos de personalidad. El objetivo de esta investigación es proponer creación y el uso de un instrumento objetivo para evaluar el desempeño técnico y determinar su confiabilidad y validez.Material y método: se seleccionaron dos procedimientos: colecistectomía laparoscópica y hernioplastia inguinal (técnica de Lichtenstein). Se constituyeron tres grupos de comparación según la experiencia quirúrgica: inicial, intermedio, y expertos. Se filmaron las cirugías en tiempo real, sin identificación del paciente ni del cirujano. Las filmaciones sin edición fueron asignadas a dos cirujanos expertos en forma aleatoria por sorteo y con sobres sin identificación. Para la evaluación se propuso el uso de un instrumento objetivo (explicitación de pasos a evaluar y cuantificación mediante escala de Likert) y específico para cada procedimiento. Así mismo se utilizó la escala global OSATS (R. Reznick). Se aplicó análisis de varianza no paramétrico para determinar validez. Valores de p menores a 0.05 fueron considerados estadísticamente significativos. Valores superiores a 0,80 del Coeficiente alfa de Cronbach aseguraron confiabilidad. Resultados: Desde Abril del 2010 hasta Diciembre del 2012 se filmaron 36 colecistectomías videolaparoscópicas y 31 hernioplastias inguinales. Se encontraron diferencias significativas entre los grupos en todos los ítems evaluados p<0.05. El coeficiente ? de

  18. [Provocative tests in the diagnosis of childhood onset growth hormone insufficiency].

    PubMed

    Gonçalves, Jean-Pierre; Correia, Filipa; Cardoso, Helena; Borges, Teresa; Oliveira, Maria João

    2014-01-01

    Introdução: A incidência da deficiência de hormona do crescimento é de 1:4000 a 1:10000, sendo a principal indicação para tratamento com hormona do crescimento recombinante.Objectivos: Avaliar os resultados dos testes de estimulação da hormona do crescimento e identificar factores preditivos para o diagnóstico da deficiência de hormona do crescimento.Material e Métodos: Estudo observacional, analítico e transversal. Foram analisados dados clínicos e auxológicos e os resultados dos exames de diagnóstico de crianças e adolescentes submetidos a testes de estimulação farmacológica da hormona do crescimento (01/01/2008 a 31/05/2012). O diagnóstico definitivo de deficiência de hormona do crescimento foi efectuado mediante dois testes com estímulos farmacológicos diferentes negativos (pico máximo da hormona do crescimento < 7 ng/mL) ou um teste negativo associado à presença de alterações anatómicas da região hipotálamo-hipofisária, observadas na ressonância magnética cerebral. Para análise estatística, foram realizados o testes de t student, do qui- quadrado, correlação de Pearson e a regressão logística. Foi considerado como nível de significância estatística (p) um valor igual ou menor que 0,05.Resultados: Realizaram-se testes de estimulação em 89 doentes, com mediana de idade igual a 10 [3-17] anos, 67% do sexo masculino e 77% pré-púberes. Os fármacos utilizados no primeiro teste de estimulação foram a clonidina (n = 85) e a insulina (n = 4). Foram diagnosticados 22 casos de deficiência de hormona do crescimento. Nos casos submetidos a dois testes, os valores máximos de hormona do crescimento apresentaram uma correlação moderada entre si (r = 0,593, p = 0,01). Verificou-se que as variáveis estatura (z-score) e pico máximo de hormona do crescimento obtido no primeiro teste têm valor preditivo no diagnóstico de deficiência de hormona do crescimento.Discussão: A determinação do IGF-1 não demonstrou ser

  19. Compilação de dados atômicos e moleculares do UV ao IV próximo para uso em síntese espectral

    NASA Astrophysics Data System (ADS)

    Coelho, P.; Barbuy, B.; Melendez, J.; Allen, D. M.; Castilho, B.

    2003-08-01

    Espectros sintéticos são utéis em uma grande variedade de aplicações, desde análise de abundâncias em espectros estelares de alta resolução ao estudo de populações estelares em espectros integrados. A confiabilidade de um espectro sintético depende do modelo de atmosfera adotado, do código de formação de linhas e da qualidade dos dados atômicos e moleculares que são determinantes no cálculo das opacidades da fotosfera. O nosso grupo no departamento de Astronomia no IAG tem utilizado espectros sintéticos há mais de 15 anos, em aplicações voltadas principalmente para a análise de abundâncias de estrelas G, K e M e populações estelares velhas. Ao longo desse tempo, as listas de linhas vieram sendo construídas e atualizadas continuamente, e alguns acréscimos recentes podem ser citados: Castilho (1999, átomos e moléculas no UV), Schiavon (1998, bandas moleculares de TiO) e Melendez (2001, átomos e moléculas no IV próximo). Com o intuito de calcular uma grade de espectros do UV ao IV próximo para uso no estudo de populações estelares velhas, se fazia necessário compilar e homogeneizar as diversas listas em apenas uma lista atômica e uma molecular. Nesse processo, a nova lista compilada foi correlacionada com outras bases de dados (NIST, Kurucz Database, O' Brian et al. 1991) para atualização dos parâmetros que caracterizam a transição atômica (comprimento de onda, log gf e potencial de excitação). Adicionalmente as constantes de interação C6 foram calculadas segundo a teoria de Anstee & O'Mara (1995) e artigos posteriores. As bandas moleculares de CH e CN foram recalculadas com o programa LIFBASE (Luque & Crosley 1999). Nesse poster estão detalhados os procedimentos citados acima, as comparações entre espectros calculados com as novas listas e espectros observados em alta resolução do Sol e de Arcturus, e uma análise do impacto decorrente da utilização de diferentes modelos de atmosfera no espectro sintético. Ao

  20. [FIXING DEVICE FOR CLOSING AND COUPLING AN INTRAVENOUS CATHETER].

    PubMed

    Soriano, Enrique; García, Jesús M; Blaya, Fernando; Islán, Manuel E; Gallego, Luis Tomás; Franco-López, Ángeles; García de Lorenzo, Abelardo

    2015-09-01

    Introducción: los medios de fijación a la piel de un catéter venoso periférico, de un catéter venoso central o de un catéter arterial central presentan los siguientes graves inconvenientes: ser la sede de infecciones a nivel del lugar de la punción, provocar una saturación de la zona anatómica, la cual resulta muy difícil de soportar e incómodo para el paciente portador, y suponer un riesgo para el personal de enfermería cuando se usan hilos de sutura para fijar el soporte del catéter. Objetivo: por lo anteriormente expuesto, se ha detectado la necesidad de diseñar un dispositivo que reduzca la complejidad y aparatosidad de los sistemas conocidos y empleados en la actualidad, favoreciendo la asepsia y la movilidad del paciente. Método: el desarrollo presentado en este artículo se refiere a un sistema mecánico de fijación, cierre y acoplamiento para catéter de perfusión intravenosa. El sistema dispone de una pieza circular de pequeño espesor con al menos dos orificios para su fijación subcutánea, centralmente de uno o más conductos para acoplar lúmenes, y de una parte cilíndrica hueca que sobresale a uno de los lados, exteriormente roscada e interiormente lisa con un tetón de posición. Para uso domiciliario se dispone de un tapón de estanqueidad con uno o más tubos de pequeño diámetro que se acoplan en los orificios para lúmenes, una ranura de posición, un tirador y un tapón roscado ciego para el cierre hermético con la parte roscada. Para uso hospitalario se dispone de un tapón intermedio con una o más entradas para lúmenes, así como de un tapón roscado hueco que permite su acoplamiento hermético con la parte roscada. Resultados: el desarrollo descrito en este artículo va a ser utilizado en dos ambientes: ambiente domiciliario y ambiente hospitalario. Además, reduce el riesgo de infección y saturación de la zona anatómica de los pacientes en los que se realiza la punción cutánea en la que se fijan catéteres venosos

  1. Condiciones Físicas en Nebulosas Gaseosas

    NASA Astrophysics Data System (ADS)

    Luridiana, V.

    1999-03-01

    El presente trabajo se ha enfocado a determinar y entender las condiciones físicas en una variedad de objetos nebulares, prestando particular atención al problema de la determinación de las abundancias químicas. Para este fin, hemos utilizado métodos analíticos en algunos casos, y modelos numéricos de fotoionización en otros. El objetivo general del trabajo es proveer de una visión amplia de las herramientas teórico-observacionales que se utilizan para la determinación de la estructura de temperatura y densidad de las regiones fotoionizadas, poniendo en evidencia posibles fuentes de errores sistemáticos y sus consecuencias para la determinación de las abundancias químicas, y proponiendo métodos para corregirlos. Los resultados principales de este trabajo est´n listados a continuación: a) Se discute el problema de la discrepancia entre T(C III) y T(O III) en las nebulosas planetarias, y se muestra como tal discrepancia implica probablemente la presencia de fluctuaciones de temperatura. Debido a que la temperatura de O++ es muy afectada por fluctuaciones de temperatura, se recomienda usar la temperatura de C++ para determinar la abundancia de carbono. b) Presentamos dos nuevos métodos para determinar la temperatura electrónica en nebulosas planetarias, basados en la medición de las intensidades de las líneas de He I. Las temperaturas que se obtienen a partir de estos métodos son menores que aquellas que se obtienen a partir de las líneas de [O III], implicando la presencia de fluctuaciones espaciales de temperatura. Despreciando las fluctuaciones de temperatura, se obtienen valores sesgados de las abundancias químicas. Determinamos las abundancias en las nebulosas planetarias de tipo I de algunos de los elementos más importantes, tomando en cuenta las fluctuaciones de temperatura. c) Presentamos modelos numéricos de las dos regiones H II extragalácticas gigantes NGC 2363 y NGC 5461. Con el modelaje numérico, pretendemos acotar las car

  2. [EFFICIENCY OF HAEMOGLOBIN REGENERATION IN THE NUTRITIONAL FERROPENIC ANAEMIA RECOVERY WITH GOAT MILK-BASED DIETS].

    PubMed

    Serrano Reina, José Antonio; Nestares Pleguezuelo, Teresa; Muñoz Alférez, Ma José; Díaz Castro, Javier; López Aliaga, Ma Inmaculada

    2015-10-01

    Objetivo: a pesar de la alta incidencia de anemia ferropénica y de los efectos beneficiosos derivados del consumo de leche de cabra, poco se conoce, en realidad, acerca de la recuperación de la anemia mediante una dieta equilibrada acompañada de la ingesta de leche de cabra. El objetivo del presente estudio es determinar, en ratas con anemia ferropénica nutricional, los efectos de dietas elaboradas a base de leche de cabra, en comparación con la de vaca, suministradas durante 30 días, sobre la recuperación de la anemia y la eficacia de regeneración de la hemoglobina. Material y métodos: se han utilizado 40 ratas macho Wistar albina recién destetadas divididas al azar en dos grupos experimentales y alimentadas ad libitum durante 40 días con dieta AIN-93G con contenido normal de hierro (grupo control, 45 mg/kg dieta), o bajo (grupo anémico, 5 mg/kg dieta). Se toman muestras de sangre de la vena caudal para el control hematológico de la anemia. Posteriormente, cada uno de los dos grupos experimentales (control y ferrodeficiente) fueron alimentados durante 30 días con dietas elaboradas a base de leche de cabra o vaca. Al finalizar el período experimental y previa anestesia, las ratas se desangran por canulación de la aorta abdominal, y la sangre obtenida se recoge en un tubo con EDTA como anticoagulante para la posterior determinación de los parámetros hematológicos y la eficacia de regeneración de la hemoglobina. Resultados y discusión: tras el consumo de una dieta con bajo contenido en hierro durante 40 días, las ratas eran anémicas, con una concentración de hemoglobina, hematocrito, hierro sérico, volumen corpuscular medio (VCM), ferritina sérica y saturación de la transferrina bajos (p < 0,001), mientras que los niveles de plaquetas y la capacidad total de unión al hierro (TIBC) estaban elevados (p < 0,001), hallazgos consistentes con la anemia inducida experimentalmente en ratas. La eficacia de regeneración de la hemoglobina era mayor

  3. LETTERS TO THE EDITORS: Lightning ball: experiments on creation and hypotheses(comment on "Energy density calculations for ball-lightning-like luminous silicon balls" by G S Paiva, J V Ferreira, C C Bastos, M V P dos Santos, A C Pavão)

    NASA Astrophysics Data System (ADS)

    Shabanov, Gennadii D.

    2010-05-01

    The problems addressed in this paper include estimating: the energy density of luminous silicon balls, the density range of a natural lightning ball, and whether and how the object created and described in the commented paper (Usp. Fiz. Nauk 180 218 (2010) [Phys. Usp. 53 (2) 209 (2010)]) corresponds to the natural phenomenon.

  4. Reading: Students' Attitudes and Interests in Fourth, Fifth, and Sixth Grades in Official Portuguese Schools in the USA (A Leitura: Atitudes e Preferencias dos Educandos do 4th, 5th, e 6th Anos de Escolaridade nas Escolas Oficiais Portuguesas nos Estados Unidos da America).

    ERIC Educational Resources Information Center

    Castanho, Maria da Graca Borges

    A study investigated attitudes and preferences concerning reading among fourth-, fifth-, and sixth-grade students in Portuguese-language schools in the United States. Extrinsic factors influencing students (parents, teachers) were also analyzed. The research took place in 10 schools in 5 states. Data were obtained using questionnaires (students)…

  5. Lo que Piensan los Estudiantes y Profesores Sobre la Calidad de la Educacion Superior. Estudio Comparativo en 5 Instituciones de Educacion Superior--dos publicas y tres privadas--en Guadalajara, Jalisco, Mexico (What Students and Faculties Think about the Quality of Higher Education. Comparative Study of 5 Higher Education Institutions--Two Public and Three Private--in Guadalajara, Jalisco, Mexico).

    ERIC Educational Resources Information Center

    Yanez, Maria Lorena Hernandez

    This study, written in Spanish, compared attitudes of students (N=302) and faculty (N=28) at five institutions of higher education (two public and three private) in Guadalajara, Jalisco, Mexico. The study explored first, whether respondents believed there are significant quality differences between private and public universities and, second, what…

  6. Communicacion Expresiva: Como los ninos nos envian mensajes [and] Comunicacion Receptiva: Como los ninos entienden nuestros mensajes [and] Interacciones de Comunicacion: Hacen falta dos. Hojas informativa de DB-LINK (Communication Interactions: It Takes Two [and] Receptive Communication: How Children Understand Your Messages to Them [and] Expressive Communication: How Children Send Their Messages to You. DB-LINK Fact Sheets).

    ERIC Educational Resources Information Center

    Stremel, Kathleen

    This document consists of three separately published fact sheets combined here because of the close relationship of their subject matter. The first fact sheet, "Communication Interactions: It Takes Two" (Kathleen Stremel), defines communication; suggests ways to find opportunities for interactive communication; offers specific suggestions for…

  7. O Passado como Nacao: Imagens do Imperio nas Falas Reacionarias dos Anos 30 e 40 do Seculo XX: Uma Pequena Arqueologia do Debate Publico e Privado (The Past as Nation: Images of the Empire in the Reactionary Words of the 30s and 40s in the 20th Century: A Small Archaeology of the Public Debate versus the Private One).

    ERIC Educational Resources Information Center

    de Freitas, Marcos Cezar

    1998-01-01

    Suggests an archaeology of the public debate versus the private one in Brazil through analysis of the reactionary speech of a religious leader, Dom Jose Mauricio da Rocha, which produced innumerable representations of the Brazilian Empire. (PA)

  8. Development of Educational Resources to Include the Teaching of Astronomy in the First Years of the Basic Education. (Spanish Title: Desarrollo de Recursos Pedagógicos Para Incluir la Enseñanza de la Astronomía en los Primeros Años de la Educación Básica.) Desenvolvimento de Recursos Pedagógicos Para Inserir o Ensino de Astronomia nas Séries Iniciais do Ensino Fundamental

    NASA Astrophysics Data System (ADS)

    da Silva Morett, Samara; de Oliveira Souza, Marcelo

    2010-07-01

    ía y la vida cotidiana de los estudiantes. La inclusión de la astronomía en la escuela primaria es una manera de demostrar a los estudiantes cómo este campo está presente de forma activa en su vida cotidiana. Las clases que participan en el proyecto participaron en un estudio con el objetivo de proporcionar información a los conocimientos previos que tenían sobre los temas de la astronomía que se examinaron durante el proyecto. Con los experimentos realizados, y la ayuda de las nuevas tecnologías, conceptos astronómicos fueron presentados a los estudiantes de 4to y 5to año de la educación básica de una escuela municipal de Campos dos Goytacazes (RJ). Después de las presentaciones nuevos datos fueran colectados y se han llevado a cabo con el fin de verificar el nivel de aprendizaje alcanzado y se observó que el método utilizado fue una herramienta importante para ayudar al proceso de enseñanza y aprendizaje. El proyecto logró resultados satisfactorios. Neste trabalho será apresentado o desenvolvimento de recursos pedagógicos para a apresentação de conceitos de astronomia nas séries iniciais do ensino fundamental. Este material é composto por apresentações realizadas com o uso de novos recursos tecnológicos, pela fabricação de experimentos e a discussão de curiosidades relativas a esta área de conhecimento. Os experimentos foram construídos com material de baixo custo com o objetivo de permitir que os alunos envolvidos pudessem refazê-los em outras ocasiões. O material apresentado busca enfatizar a relação entre a astronomia e o cotidiano dos alunos. A inclusão da astronomia no ensino fundamental e uma forma de demonstrar aoestudante como esta área está presente de forma ativa em seu cotidiano. As turmas envolvidas no projeto participaram de uma pesquisa com o objetivo de obter dados relativos ao conhecimento prévio que possuíam sobre os tópicos de astronomia que foram considerados no decorrer do projeto. Com os experimentos

  9. Whenever You Use a Computer You Are Using a Program Called an Operating System.

    ERIC Educational Resources Information Center

    Cook, Rick

    1984-01-01

    Examines design, features, and shortcomings of eight disk-based operating systems designed for general use that are popular or most likely to affect the future of microcomputing. Included are the CP/M family, MS-DOS, Apple DOS/ProDOS, Unix, Pick, the p-System, TRSDOS, and Macintosh/Lisa. (MBR)

  10. Software Reviews.

    ERIC Educational Resources Information Center

    Bitter, Gary G., Ed.

    1989-01-01

    Reviews three software packages: (1) "The Weather Machine Courseware Kit" for grades 7-12; (2) "Exploring Measurement, Time, and Money--Level I," for primary level mathematics; and (3) "Professor DOS with SmartGuide for DOS" providing an extensive tutorial covering DOS 2.1 to 4.0. Discusses the strengths and weaknesses of each package. (YP)

  11. Biochemical and biophysical investigation of surfactant in neonatal gastric aspirate at birth.

    PubMed

    Bangyozova, Maya; Jordanova, Albena; Tsanova, Asya; Jekova, Neli; Chakarov, Decho; Doumanov, Jordan; Christova, Emilia; Lalchev, Zdravko

    2013-01-01

    Introdução: A melhor abordagem para detecção de deficiência de surfactante em recém-nascidos prematuros no nascimento permanece pouco clara e a decisão de aplicar surfactante exógeno é baseada principalmente no desenvolvimento de sinais clínicos e radiológicos da síndrome de angústia respiratória neonatal (NRDS). Objetivos: Estudamos as propriedades bioquímicas e biofísicas do aspirado gástrico (GA) de crianças nascidas prematuramente com NRDS e saudáveis nascidos a termo, com o objetivo de encontrar um método acessível para avaliação da maturidade do surfactante no nascimento. Material e Métodos: Quarenta e sete recém-nascidos, divididos em dois grupos foram incluídos no estudo. O primeiro grupo composto por 34 crianças saudáveis nascidas a termo (após 37 semanas de gestação). O segundo grupo incluiu 13 recém-nascidos prematuros (idade entre 26 - 32 semanas de gestação) desenvolveram sinais clínicos de NRDS para os quais foram tratados por ventilação assistida e surfactante exógeno. A análise bioquímica da proteína e lipídio da GA coletado no nascimento foi realizado. A composição de ácidos graxos das amostras GA foi determinada pelo detector de cromatografia de massa seletiva (GS-MSD) análise. As características da superfície (de equilíbrio, os valores máximo e mínimo de tensão de superfície) das amostras de AG foram medidos utilizando o método de gota pendente. Os dados foram comparados entre os grupos, utilizando o teste t de Student ou teste de Mann-Whitney análise. Os valores foram considerados significativamente diferentes se o valor de p ≤ 0,05. Resultados: A concentração média de fosfolipídeos em GA dos prematuros foi menor (295,7 g / ml vs 374,5 mg / ml) do que em crianças a termo e do conteúdo médio de proteína foi menor no GA dos bebês prematuros que o termo recém-nascidos (574,5 ng / ml vs 641,5 ug / ml). A medição das características de superfície dinâmicas da GA mostraram

  12. Evaluation of probabilistic flow in two unsaturated soils

    NASA Astrophysics Data System (ADS)

    Boateng, Samuel

    2001-11-01

    ées. Les propriétés sont basées sur le modèle de van Genuchten. Le domaine d'écoulement possède une surface de recharge, une limite de fuite à sa base et des limites sans écoulement sur les côtés. Les variables incertaines sont la teneur en eau à saturation, la teneur en eau résiduelle, les paramètres alpha (α) et n du modèle de van Genuchten et la conductivité hydraulique à saturation. L'objectif est d'évaluer la signification de chacune des variables incertaines dans l'écoulement probabiliste. Dans des conditions humides, la teneur en eau à saturation et la teneur en eau résiduelle sont les variables incertaines les plus significatives dans le sable. Toutefois, dans des conditions sèches dans le sable, les paramètres α et n du modèle de van Genuchten sont les plus significatifs. Le paramètre n du modèle et la conductivité hydraulique à saturation sont les plus significatifs pour un sol argileux humide. La teneur en eau à saturation est très significative pour le sol argileux sec. Resumen. Se ha acoplado un modelo de flujo de saturación variable con un algoritmo de fiabilidad de primer orden con el fin de simular el flujo no saturado en dos tipos de suelos. Se ha tratado las propiedades del suelo no saturado como variables inciertas, a las que se asigna las medias, desviaciones estándar y distribuciones de probabilidad marginal correspondientes. Así, cada simulación constituye un evento probabilístico de flujo no saturado y la sensibilidad de las variables inciertas es estimada para cada evento. Se ha utilizado las propiedades de la conductividad hidráulica no saturada de dos suelos con dos tipos de textura - fina y gruesa - mediante el modelo de van Genuchten. El dominio de flujo está delimitado por una superficie de recarga, base de goteo y contornos laterales de flujo nulo. Las variables inciertas son el contenido de agua residual, el de saturación, los parámetros del modelo de van Genuchten (α y n) y la conductividad hidr

  13. A Diagnostic Assessment for the Teaching of Astronomy. (Spanish Title: Una Evaluación Diagnóstica Para la Enseñanza de la Astronomia.) Uma Avaliação Diagnóstica Para o Ensino da Astronomia

    NASA Astrophysics Data System (ADS)

    Pacifico Ribeiro de Assis Silveira, Felipa; Soares Gomes de Sousa, Célia Maria; Moreira, Antonio

    2011-07-01

    interpretación, lo que nos permite comprender los significados asignados por el estudiante a estos conceptos. Se desprende de la evaluación diagnóstica que la mayoría de los encuestados ha tenido dificultades para exponer los conceptos científicos sobre el Universo y la Tierra, para iniciar el 6 º grado. Sin embargo, se identificaron ideas relevantes y las representaciones que contribuyeron a la re-significación de los conceptos científicos propuestos para la enseñanza del tema en esta serie. Los resultados de la evaluación diagnóstica han servido como referencia para la organización del Programa, facilitando el proceso de aprendizaje, haciendo coincidir la secuencia didáctica a las características de los estudiantes y el contexto del aula. Se espera que el instrumento presentado en este documento también pueda ser utilizado por otros investigadores en investigaciones relacionadas con el tema. Este artigo tem como objetivo apresentar os resultados de uma avaliação diagnóstica, utilizada como instrumento para a coleta de dados sobre o conhecimento prévio de conceitos científicos, necessários à compreensão do tema Terra e Universo, de um grupo composto por 47 estudantes, da 6ª série do Ensino Fundamental. A ação pedagógica de diagnosticar os conhecimentos prévios, do estudante, antes de ensiná-los, tem fundamento na teoria da Aprendizagem Significativa, proposta por David Ausubel. Essa avaliação diagnóstica foi composta por 25 questões, cujas respostas foram analisadas e categorizadas visando sua interpretação, o que permitiu compreender os significados atribuídos pelo estudante a esses conceitos. Conclui-se, a partir da avaliação diagnóstica, que a maioria dos estudantes pesquisados apresentou dificuldades em expor conceitos científicos sobre o tema Terra e Universo ao iniciar a 6ª série. Entretanto, foram identificadas ideias e representações relevantes que contribuíram para a (re)significação dos conceitos científicos propostos

  14. The influence of faults in basin-fill deposits on land subsidence, Las Vegas Valley, Nevada, USA

    NASA Astrophysics Data System (ADS)

    Burbey, Thomas

    2002-07-01

    -dimensional consolidation. Jour. Applied Physics 12:155-164), a été utilisé pour évaluer la nature du déplacement au voisinage de deux failles verticales. La faille a été simulée comme 1) une barrière de faible perméabilité pour l'écoulement horizontal, 2) une rupture structurale dans le milieu, mais sans obstruction de l'écoulement, et 3) une combinaison des deux précédentes conditions. Les résultats indiquent que la barrière de faible perméabilité favorise fortement le déplacement horizontal. Le plan de faille constitue aussi un lieu de subsidence différentielle verticale significative. Les fortes contraintes calculées au voisinage de la faille laissent penser qu'il existe un fort potentiel de rupture et le développement de fissures du sol quand on suppose que la faille possède une faible perméabilité. Les résultats utilisant une combinaison des deux conditions suggèrent que le développement potentiel de fissures peut être grand sur ou à proximité du plan de faille et que la déformation horizontale joue vraisemblablement un rôle clé dans ce développement. Resumen. Se conoce la contribución que la deformación horizontal causada por el bombeo de sistemas acuíferos confinados tienen en el desarrollo de fisuras en regiones semiáridas, como es el caso del Valle de Las Vegas (Nevada, Estados Unidos de América). A pesar de la estabilización de los niveles, se continúa desarrollando nuevas fisuras, mientras las ya existentes se alargan y ensanchan cerca de las fallas de relleno de cuenca. Se ha utilizado un modelo tridimensional de desplazamiento granular basado en la teoría de consolidación de Biot (Biot, M.A., 1941. General theory of three-dimensional consolidation. J. Applied Physics, 12: 155-164) para evaluar la naturaleza del desplazamiento junto a dos fallas verticales. Se ha simulado cada falla como (1) una barrera de baja permeabilidad al flujo horizontal, (2) un hueco o ruptura estructural en el medio pero sin obstrucción al flujo de aguas

  15. [Validation of a method of dispensing nutritional supplements in a tertiary hospital].

    PubMed

    Oliva García, José Gregorio; Pereyra-García Castro, Francisca; Benítez Brito, Néstor; Herrera Rodríguez, Eva María; Suárez Llanos, José Pablo; García Bray, Bruno Francisco; Palacio Abizanda, José Enrique

    2013-01-01

    Introducción: Los suplementos nutricionales constituyen un pilar fundamental del tratamiento de la desnutrición hospitalaria, aunque su coste es elevado. Son precisos métodos que permitan una prescripción racional de los mismos. Objetivos: Analizar la validez de los criterios de dispensación de suplementos nutricionales (SN) utilizados en nuestro centro (empleando como referencia el sistema CONUT). Material y métodos: Se revisaron retrospectivamente los formularios de solicitud de SN remitidos por los distintos servicios durante 15 meses (abril/2010-junio/2011). Se analizaron las siguientes variables: servicio solicitante, patología, IMC, pérdida de peso reciente, disminución de la ingesta mayor del 50%, proteínas totales, albúmina, linfocitos, colesterol total y valoración del grado de desnutrición según sistema CONUT. Se comparó la validez de nuestros criterios de dispensación de SN con el sistema CONUT (empleando el coeficiente Kappa). Resultados: Se recibieron 524 solicitudes (34,9/mes). Patologías: infecciosa (31,1%), tumoral (26,1%), postquirúrgica (19%), otras (23,8%). Había pérdida de peso reciente en el 88,9% de los pacientes, y una disminución de la ingesta superior al 50% en el 83,4%. IMC: 24,8 ± 7,5 kg/m2. Parámetros analíticos: albúmina 2,6 ± 0,7 g/dl, proteínas totales 5,7 ± 2,4 g/dl, colesterol total 152 ± 172 mg/dl, linfocitos 1.561 ± 1.842/mm3. Valoración del grado de desnutrición según sistema CONUT: normal (12%), desnutrición leve (23,1%), moderada (41,6%), grave (23,3%). Cumplimiento de los requisitos de nuestro centro hospitalario para la dispensación de SN: ninguno (6,3%), uno (33,6%), dos (43,1%), los tres (17%). Se comparó el número de dichos requisitos con el grado de desnutrición (sistema CONUT), obteniéndose un índice de concordancia débil (Kappa = 0,207; p < 0,001). 156 pacientes (29,8% de las solicitudes) recibieron SN, a pesar de presentar grado de nutrición normal o desnutrición leve de

  16. Depression and anxiety following deep brain stimulation in Parkinson's disease: systematic review and meta-analysis.

    PubMed

    Couto, Maria Inês; Monteiro, Ana; Oliveira, Ana; Lunet, Nuno; Massano, João

    2014-01-01

    Introdução: A estimulação cerebral profunda (ECP) é eficaz na doença de Parkinson (DP) avançada, melhorando sintomas motores, flutuações e a qualidade de vida. No entanto, têm sido reportados efeitos adversos psiquiátricos, mas de uma forma variável e não padronizada. O objectivo deste artigo é analisar e sumarizar a evidência publicada sobre sintomas depressivos e ansiedade em doentes com DP após ECP, através de revisão sistemática e meta-análise. Material e Métodos: A PubMed foi pesquisada até Maio 2012 para identificar os estudos que avaliaram sintomas depressivos e ansiedade em doentes com doença de Parkinson submetidos a estimulação cerebral profunda bilateral do núcleo subtalâmico (NST) ou globo pálido interno (GPi). Foram feitas meta-análises com modelo de efeitos aleatórios para grupos de pelo menos três estudos homogéneos em relação ao desenho e instrumentos utilizados. Resultados: Foram selecionadas 63 referências; 98,4% continham dados relativos a escalas de avaliação de depressão e 38,1% relativos a ansiedade. Dois estudos não discriminavam o alvo usado; nos restantes 61 foi feita avaliação de curto prazo em 37 (60,7%), de médio prazo em 36 (59,0%) e de longo prazo em 5 (8,2%). Foram encontrados dados sobre variação pré/pós operatória em 57 (93,4%) estudos e 16 (26,2%) continham dados comparando ECP-NST versus outros grupos: ECP-GPi (n = 4 estudos, 25,0%), elegíveis para cirurgia (n = 6, 37,5%), e tratamento médico (n = 7, 43,8%). Discussão: É aparente a melhoria de depressão e ansiedade após ECP, sobretudo a curto prazo, efeito que tende a esbater-se em avaliações posteriores. Em relação à depressão a ECP-NST mostrou-se superior ao tratamento médico, mas não em comparação com o grupo de controlo elegível para cirurgia. Verificou-se o resultado oposto para a ansiedade, uma vez que os resultados favorecem o tratamento médico sobre a ECP-NST, e esta sobre o grupo de elegíveis para cirurgia

  17. Effectiveness of psychosocial interventions in eating disorders: an overview of Cochrane systematic reviews.

    PubMed

    Costa, Marcelle Barrueco; Melnik, Tamara

    2016-01-01

    ão geral das evidências científicas sobre a efetividade das intervenções psicossociais no tratamento de transtornos alimentares. Foram incluídas todas as revisões sistemáticas publicadas no Banco de Dados de Revisões Sistemáticas da Cochrane Library. Posteriormente, a partir da data menos recente destas revisões (2001), realizou-se uma busca adicional no PubMed, com estratégia de busca sensibilizada e com os mesmos descritores utilizados antes. No total, foram incluídos 101 estudos primários e 30 revisões sistemáticas (5 revisões sistemáticas da Cochrane), metanálises, diretrizes ou revisões narrativas da literatura. Os principais desfechos foram remissão de sintomas, imagem corporal, distorção cognitiva, comorbidade psiquiátrica, funcionamento psicossocial e satisfação do paciente. A abordagem cognitivo-comportamental foi o tratamento mais efetivo, principalmente para bulimia nervosa, transtorno da compulsão alimentar periódica e síndrome do comer noturno. Para anorexia nervosa, a abordagem familiar demonstrou maior efetividade. Outras abordagens efetivas foram psicoterapia interpessoal, terapia comportamental dialética, terapia de apoio e manuais de autoajuda. Além disso, houve um número crescente de abordagens preventivas e promocionais que contemplaram fatores de risco individuais, familiares e sociais, sendo promissoras para o desenvolvimento da autoimagem positiva e autoeficácia. São necessários mais estudos que avaliem o impacto de abordagens multidisciplinares em todos transtornos alimentares, além da relação custo-efetividade de algumas modalidades efetivas, como a terapia cognitivo-comportamental.

  18. [Adaptation and psychometric proprieties study for the Portuguese version of the Adolescent Coping Scale - Escala de Coping para Adolescentes].

    PubMed

    Guerreiro, Diogo Frasquilho; Cruz, Diana; Figueira, Maria Luísa; Sampaio, Daniel

    2014-01-01

    Introdução: O coping é um processo psicológico que leva ao ajustamento individual perante situações de stress. A Adolescent Coping Scale é um instrumento de investigação e uma ferramenta clínica, amplamente utilizada. O presente estudo tem como objectivos desenvolver uma versão Portuguesa da Adolescent Coping Scale e analisar as estratégias e estilos de coping dos jovens da nossa amostra.Material e Métodos: Um questionário anónimo compreendendo a Adolescent Coping Scale obteve respostas de 1 713 alunos (56% do sexo feminino, com idades compreendidas entre os 12 e os 20 anos e uma média etária de 16). O estudo de validade da escala contemplou: análise em componentes principais e avaliação da consistência interna; análise confirmatória através de modelo de equações estruturais. Posteriormente, foram comparadas por género as estratégias e estilos de coping da amostra (testes t para amostras independentes).Resultados: A estrutura final da adaptação da Adolescent Coping Scale reteve 70 itens, que avaliam 16 estratégias de coping agrupadas em três estilos distintos. As escalas apresentaram bons valores de consistência interna (alfas de Cronbach compreendidos entre 0,63 e 0,86, com a exceção de uma dimensão que apresentou um valor de 0,55) e o modelo confirmatório demonstrou bom fit (goodness of fit index compreendidos entre 0,94 e 0,96). Foram eliminadas duas estratégias de coping por motivos estatísticos (ausência de saturação de itens suficientes nas dimensões correspondentes). Verificámos que o estilo de coping focado na resolução do problema é aquele maioritariamente utilizado pelos adolescentes da nossa amostra, em ambos os sexos. No sexo feminino observaram-se valores médios mais elevados nos estilos de coping não produtivo e de referência a outros.Discussão: A versão adaptada apresenta elevada semelhança com a escala original, com alterações minor espectáveis tendo em conta que o coping é influenciado por

  19. Um Projeto de Intervenção nos Espaços de Exposições do Planetário do Parque do Ibirapuera

    NASA Astrophysics Data System (ADS)

    Elias, D. S.; Amaral, L. H.; de Araújo, C. F., Jr.; Matsuura, O. T.; Voelzke, M. R.

    2005-08-01

    Cada vez mais a humanidade, em sua imensa maioria, está alheia às próprias conquistas. A insatisfação com esta realidade tem levado muitos pesquisadores, instituições, empresas e governos a procurar formas alternativas de acompanhar e transmitir todo este acervo científico cultural à sociedade, buscando a melhoria da qualidade da divulgação científica e contribuindo para o processo de cultura e alfabetização científica. Não há tempo nem espaço nos limitados planos curriculares do ensino médio e mesmo nos programas de ensino que propiciem a cultura científica e o acompanhamento do vertiginoso progresso científico e tecnológico atual. Neste sentido, a educação formal escolar precisa ser complementada ou acrescida de uma educação informal, extra-escolar, que possa oferecer à sociedade o que a escola não pode oferecer. A interação do público com museus, feiras de ciências, planetários, exposições científicas e/ou culturais é de grande importância para a aquisição e difusão de conhecimentos relacionados ao mundo científico. Reconhecidamente como um modelo de alfabetização científica esses ambientes promovem uma interação social capaz de propiciar de forma efetiva uma melhor relação ensino-aprendizagem com o público. Partindo desta realidade a Universidade Cruzeiro do Sul e a Escola Municipal de Astronomia (EMA) vêm desenvolvendo um projeto de intervenção no espaço em torno do Planetário do Parque do Ibirapuera com o objetivo de se implantar um ambiente de aprendizagem motivador e desafiador que promova a popularização de conteúdos relacionados à astronomia, astrofísica e cosmologia. Busca-se, também, a aproximação e interação do público com exposições que estão sendo implementadas no planetário. Considerando que se trata de um projeto de mestrado em fase inicial o objetivo do presente trabalho é apresentar a concepção básica e os critérios que estão sendo utilizados do ponto de vista pedag

  20. Modelo analítico del efecto de PRS sobre satélites GPS

    NASA Astrophysics Data System (ADS)

    Meza, A.; Brunini, C.; Usandivaras, J. C.

    El sistema GPS (Global Position System) es, hoy en día, la herramienta de navegación y posicionamiento más potente y lo será sin duda en la próxima década. Gran parte de su valiosa utilidad se debe a la alta precisión que permite lograr y ésta, a su vez, depende, entre otras causas, de la precisión con que se conocen las órbitas de los satélites. La presión de radiación solar (PRS) fija el límite de la precisión con que pueden calcularse en la actualidad las efemérides satelitarias. El objetivo de este trabajo es proponer una mejor resolución de este fenómeno. El modelo analítico aquí presentado, se basa en el análisis del comportamiento de los residuos de un ajuste por mínimos cuadrados en el que se utiliza el modelo de PRS propuesto por Beutler. El mismo consiste en un modelo determinista del fenómeno con dos parámetros libres. Los resultados obtenidos ponen de manifiesto que, aún después de aplicar dichos parámetros, prevalecen en los residuos efectos semidiurnos en las componentes radial,tangencial y normal. Estos resultados obtenidos se comparan con los de un trabajo desarrollado por el Instituto de Berne (Beutler et al., 1994), en el que se utilizaron como pseudo-observaciones las órbitas precisas del IGS (CODE). El intervalo de integración escogido por este centro fueron las semanas 680 y 681. En resumen se tienen arcos de 14 días para todos los satélites, donde las efemérides precisas de los mismos para los 14 días fueron utilizados como pseudo-observaciones. El modelo de fuerza que empleó dicho centro fue básicamente el tradicional en lo que respecta al modelo de las fuerzas gravitacionales, y para la PRS utilizo el modelo standard de Beutler. Los parámetros de este modelo junto con las 6 condiciones iniciales (posición y velocidad) fueron ajustados por el método general de mínimos cuadrados. Los residuos en la componente radial, tangencial y normal, para los satélites con un buen comportamiento, presentan una

  1. Effectiveness of psychosocial interventions in eating disorders: an overview of Cochrane systematic reviews.

    PubMed

    Costa, Marcelle Barrueco; Melnik, Tamara

    2016-01-01

    ão geral das evidências científicas sobre a efetividade das intervenções psicossociais no tratamento de transtornos alimentares. Foram incluídas todas as revisões sistemáticas publicadas no Banco de Dados de Revisões Sistemáticas da Cochrane Library. Posteriormente, a partir da data menos recente destas revisões (2001), realizou-se uma busca adicional no PubMed, com estratégia de busca sensibilizada e com os mesmos descritores utilizados antes. No total, foram incluídos 101 estudos primários e 30 revisões sistemáticas (5 revisões sistemáticas da Cochrane), metanálises, diretrizes ou revisões narrativas da literatura. Os principais desfechos foram remissão de sintomas, imagem corporal, distorção cognitiva, comorbidade psiquiátrica, funcionamento psicossocial e satisfação do paciente. A abordagem cognitivo-comportamental foi o tratamento mais efetivo, principalmente para bulimia nervosa, transtorno da compulsão alimentar periódica e síndrome do comer noturno. Para anorexia nervosa, a abordagem familiar demonstrou maior efetividade. Outras abordagens efetivas foram psicoterapia interpessoal, terapia comportamental dialética, terapia de apoio e manuais de autoajuda. Além disso, houve um número crescente de abordagens preventivas e promocionais que contemplaram fatores de risco individuais, familiares e sociais, sendo promissoras para o desenvolvimento da autoimagem positiva e autoeficácia. São necessários mais estudos que avaliem o impacto de abordagens multidisciplinares em todos transtornos alimentares, além da relação custo-efetividade de algumas modalidades efetivas, como a terapia cognitivo-comportamental. PMID:27462898

  2. La necesidad de cohetes más veloces

    NASA Video Gallery

    Los cohetes utilizados por la NASA son excelentes, pero no nos pueden llevar muy lejos ni muy rápido a aquellos lugares a los que todavía no llegamos, como Marte, o más lejos. Una solución posible ...

  3. Far tails of the density of states in amorphous organic semiconductors

    SciTech Connect

    Novikov, S. V.

    2015-10-28

    Far tails of the density of state (DOS) are calculated for the simple models of organic amorphous material, the model of dipolar glass and model of quadrupolar glass. It was found that in both models far tails are non-Gaussian. In the dipolar glass model, the DOS is symmetric around zero energy, while for the model of quadrupolar glass, the DOS is generally asymmetric and its asymmetry is directly related to the particular geometry of quadrupoles. Far tails of the DOS are relevant for the quasi-equilibrium transport of the charge carriers at low temperature. Asymmetry of DOS in quadrupolar glasses means a principal inequivalence of the random energy landscape for the transport of electrons and holes. Possible effect of the non-Gaussian shape of the far tails of the DOS on the temperature dependence of carrier drift mobility is discussed.

  4. Far tails of the density of states in amorphous organic semiconductors.

    PubMed

    Novikov, S V

    2015-10-28

    Far tails of the density of state (DOS) are calculated for the simple models of organic amorphous material, the model of dipolar glass and model of quadrupolar glass. It was found that in both models far tails are non-Gaussian. In the dipolar glass model, the DOS is symmetric around zero energy, while for the model of quadrupolar glass, the DOS is generally asymmetric and its asymmetry is directly related to the particular geometry of quadrupoles. Far tails of the DOS are relevant for the quasi-equilibrium transport of the charge carriers at low temperature. Asymmetry of DOS in quadrupolar glasses means a principal inequivalence of the random energy landscape for the transport of electrons and holes. Possible effect of the non-Gaussian shape of the far tails of the DOS on the temperature dependence of carrier drift mobility is discussed.

  5. Far tails of the density of states in amorphous organic semiconductors

    NASA Astrophysics Data System (ADS)

    Novikov, S. V.

    2015-10-01

    Far tails of the density of state (DOS) are calculated for the simple models of organic amorphous material, the model of dipolar glass and model of quadrupolar glass. It was found that in both models far tails are non-Gaussian. In the dipolar glass model, the DOS is symmetric around zero energy, while for the model of quadrupolar glass, the DOS is generally asymmetric and its asymmetry is directly related to the particular geometry of quadrupoles. Far tails of the DOS are relevant for the quasi-equilibrium transport of the charge carriers at low temperature. Asymmetry of DOS in quadrupolar glasses means a principal inequivalence of the random energy landscape for the transport of electrons and holes. Possible effect of the non-Gaussian shape of the far tails of the DOS on the temperature dependence of carrier drift mobility is discussed.

  6. Singularity of density of states induced by random bond disorder in graphene

    NASA Astrophysics Data System (ADS)

    Zhu, Lin; Wang, Xu

    2016-06-01

    We re-investigate the effect of random bond disorder on the density of states (DOS) in graphene. Our large-scale calculation supports that there exists a critical disorder value gbc dividing the DOS into two distinct structures. In the regime gb < gbc (gb is randomness of bond disorder), the DOS away from the Dirac point behaves like a power-law with positive exponent (α > 0): ρ (E) ∼ρ1 | E|α (E is Fermi energy with respect to the Dirac point, ρ1 is a constant). In the regime gb > gbc, it is observed that DOS develops a peak structure at the Dirac point E = 0. Through the finite-size scaling analysis, we elucidate that the DOS at the Dirac point diverges in the thermodynamics limit. Furthermore, it is found that the divergent behavior of DOS is sensitive to any on-site disorder which violates the chiral symmetry in graphene.

  7. Value of the Qrs-T Angle in Predicting the Induction of Ventricular Tachyarrhythmias in Patients with Chagas Disease.

    PubMed

    Zampa, Hugo Bizetto; Moreira, Dalmo Ar; Ferreira Filho, Carlos Alberto Brandão; Souza, Charles Rios; Menezes, Camila Caldas; Hirata, Henrique Seichii; Armaganijan, Luciana Vidal

    2014-10-28

    .95; CI 0.99-15.82; p = 0.052). The EF also emerged as a predictor of induction of VT / VF: for each point increase in EF, there was a 4% reduction in the rate of sustained ventricular arrhythmia on EPS. Conclusions: Changes in the QRS-T angle and decreases in EF were associated with an increased risk of induction of VT / VF on EPS.Fundamento: O ângulo QRS-T mostra correlação com prognóstico em pacientes com insuficiência cardíaca e doença coronariana, traduzido por um aumento na mortalidade proporcional ao aumento na diferença entre os eixos do complexo QRS e da onda T no plano frontal. Até hoje, nenhuma informação a este respeito foi obtida em pacientes com cardiopatia chagásica. Objetivo: Correlacionar o ângulo QRS-T com a indução de taquicardia ventricular / fibrilação ventricular (TV / FV) em chagásicos durante estudo eletrofisiológico (EEF). Métodos: Estudo caso-controle em centro terciário. Pacientes sem indução de TV / FV ao EEF foram utilizados como controles. O ângulo QRS-T foi categorizado como normal (0-105º), limítrofe (105-135º) e anormal (135-180º). As diferenças entre os grupos foram analisadas pelo teste t ou teste de Mann-Whitney para variáveis contínuas, e teste exato de Fisher ou qui-quadrado para variáveis categóricas. Valores de p < 0,05 foram considerados significativos. Resultados: De 116 pacientes submetidos ao EEF, 37,9% foram excluídos por estarem com dados incompletos / prontuários inativos ou pela impossibilidade de se calcular corretamente o ângulo QRS-T (presença de bloqueio de ramo esquerdo e fibrilação atrial). De 72 pacientes incluídos, 31 induziram TV / FV ao EEF. Destes, o ângulo QRS-T se encontrava normal em 41,9%, limítrofe em 12,9% e anormal em 45,2%. No grupo de pacientes sem indução de TV / FV, o ângulo QRS-T se encontrava normal em 63,4%, limítrofe em 14,6% e anormal em 17,1% (p = 0,04). Quando comparados aos pacientes com ângulo QRS-T normal, o risco de indução de TV / FV nos

  8. The influence of faults in basin-fill deposits on land subsidence, Las Vegas Valley, Nevada, USA

    NASA Astrophysics Data System (ADS)

    Burbey, Thomas

    2002-07-01

    -dimensional consolidation. Jour. Applied Physics 12:155-164), a été utilisé pour évaluer la nature du déplacement au voisinage de deux failles verticales. La faille a été simulée comme 1) une barrière de faible perméabilité pour l'écoulement horizontal, 2) une rupture structurale dans le milieu, mais sans obstruction de l'écoulement, et 3) une combinaison des deux précédentes conditions. Les résultats indiquent que la barrière de faible perméabilité favorise fortement le déplacement horizontal. Le plan de faille constitue aussi un lieu de subsidence différentielle verticale significative. Les fortes contraintes calculées au voisinage de la faille laissent penser qu'il existe un fort potentiel de rupture et le développement de fissures du sol quand on suppose que la faille possède une faible perméabilité. Les résultats utilisant une combinaison des deux conditions suggèrent que le développement potentiel de fissures peut être grand sur ou à proximité du plan de faille et que la déformation horizontale joue vraisemblablement un rôle clé dans ce développement. Resumen. Se conoce la contribución que la deformación horizontal causada por el bombeo de sistemas acuíferos confinados tienen en el desarrollo de fisuras en regiones semiáridas, como es el caso del Valle de Las Vegas (Nevada, Estados Unidos de América). A pesar de la estabilización de los niveles, se continúa desarrollando nuevas fisuras, mientras las ya existentes se alargan y ensanchan cerca de las fallas de relleno de cuenca. Se ha utilizado un modelo tridimensional de desplazamiento granular basado en la teoría de consolidación de Biot (Biot, M.A., 1941. General theory of three-dimensional consolidation. J. Applied Physics, 12: 155-164) para evaluar la naturaleza del desplazamiento junto a dos fallas verticales. Se ha simulado cada falla como (1) una barrera de baja permeabilidad al flujo horizontal, (2) un hueco o ruptura estructural en el medio pero sin obstrucción al flujo de aguas

  9. Tumores neonatales y malformaciones congénitas

    PubMed Central

    Tornero, O. Berbel; García, J.A. Ortega; Tortajada, J. Ferrís i; Castell, J. García; Colomer, J. Donat i; Soldin, O.P.; Soler, J.L. Fuster

    2013-01-01

    Introducción La asociación entre tumores y malformaciones congénitas está bien establecida, pero no existen datos exclusivos en el período neonatal y se desconocen los mecanismos subyacentes que generan dicha relación. Objetivos Este trabajo tiene dos objetivos: primero, analizar la frecuencia de los tumores neonatales asociados a malformaciones congénitas, y segundo, comentar las posibles hipótesis etiopatogénicas de la relación entre ambas entidades. Materiales y método Estudio retrospectivo de las historias clínicas de los tumores neonatales, en el Hospital Universitario Materno- Infantil La Fe de Valencia, desde enero de 1990 hasta diciembre de 1999. Selección y descripción de las variedades histológicas asociadas a malformaciones congénitas. Éstas se han agrupado siguiendo los criterios de la Clasificación Internacional de Enfermedades CIE-9, códigos 740.0–759.9. Revisión sistemática bibliográfica de los últimos 25 años, obtenida del Medline, Cancerlit, Index Citation Science y Embase. El perfil de búsqueda utilizado fue la combinación de “neonatal/congenital-tumors/cancer/neoplasms” y “congenital malformations/birth defects”. Resultados Se identificaron 72 tumores neonatales (2,8 % del total de tumores pediátricos diagnosticados en dichos años) y 15 de ellos (20,8 %) asociados a malformaciones congénitas, enfermedades o síndromes congénitos. Las asociaciones entre tumores neonatales y malformaciones congénitas fueron las siguientes: a) angioma en 3 pacientes: con dos cardiopatías congénitas y una atresia de coanas-laringomalacia; b) neuroblastoma en 2 pacientes: uno con riñón en herradura y anomalías vertebrales, y otro con cardiopatía congénita; c) teratoma en 2 pacientes: uno con fisura palatina y anomalías vertebrales, y otro con metatarso varo; d) tumor del sistema nervioso central en un paciente con hernia de Bochdaleck; e) tumor cardíaco en 4 pacientes con esclerosis tuberosa; f) leucemia aguda en un

  10. Dissolved organic carbon and sulfur in southwestern Quebec lakes: Relationships with catchment and lake properties

    SciTech Connect

    Houle, D.; Carignan, R.; Lachance, M.

    1995-06-01

    In 59 southwestern Quebec lakes, dissolved organic S (DOS) concentration averages 185{+-}92 {mu}g liter{sup -1} (9.2% of total S) and ranges from undetectable to 437 {mu}g liter{sup -1} (22% of total S). DOS can be predicted from dissolved organic C (DOC) concentrations: DOS ({mu}g liter{sup -1}) = 2.20 log{sub 10}(DOC) + 7, r{sup 2} = 0.55. When applied to 1,238 lakes from five Quebec regions, this relationship indicates that DOS can account for 8.5% (Ottawa) to 22.2% (North Shore) of total S. These results stress the importance of evaluating DOS concentrations in studies of catchment S budgets. Multiple regression models using lake and catchment properties as independent variables respectively explain 75, 43, 49, and 69% of the variance in DOC, DOS, DOC: DOS, and color. The regressions found for DOC, color, and DOS include a flowpath index, accounting for dissolved organic matter (DOM) leaching from the catchment, and a term for in-lake losses. The DOC:DOS regression includes the flowpath index, lake perimeter, and altitude and suggests that DOM supply and composition also depend on catchment properties. 23 refs., 3 figs., 5 tabs.

  11. Determinación de parámetros Post-Newtonianos

    NASA Astrophysics Data System (ADS)

    Orellana, R. B.; Vucetich, H.

    Icaro es un asteroide que, debido a su gran excentricidad, (0.83), puede ser utilizado para verificar la relatividad general. Tiene acercamientos periódicos a la Tierra cada 18 años aproximadamente. Los ocurridos en 1949 y 1968 permitieron realizar una primera determinación de la variación de su perihelio por efectos relativistas. En 1987 tuvo un nuevo acercamiento que permitirá mejorar los resultados existentes.

  12. Clearing a Path: The 16-Bit Operating System Jungle Offers Confusion, Not Standardization.

    ERIC Educational Resources Information Center

    Pournelle, Jerry

    1984-01-01

    Discusses the design and limited uses of the Pascal, MS-DOS, CP/M, and PC-DOS operating systems as standard operating systems for 16-bit microprocessors, especially with the more sophisticated microcomputers currently being developed. Advantages and disadvantages of Unix--a multitasking, multiuser operating system--as a standard operating system…

  13. The Challenges for Physicians of Demonstrating Continuing Competence in the Changing World of Medical Regulation: Osteopathic Pediatrician Case Report

    ERIC Educational Resources Information Center

    Langenau, Erik E.; Gimpel, John R.

    2012-01-01

    The current system of continuing medical education, maintenance of certification, and renewal of medical licenses can be quite burdensome and inefficient for all practicing physicians: medical doctors (M.D.s) and doctors of osteopathic medicine (D.O.s). D.O.s have opportunities for residency training and specialty certification which are not…

  14. 76 FR 5298 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Model EMB-500 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034... Support, Av. Brig. Farina Lima, 2170, Sao Jose dos Campos-- SP, CEP: 12227-901--PO Box: 36/2, BRASIL.... Farina Lima, 2170, Sao Jose dos Campos-SP, CEP: 12227-901--PO Box: 36/2, BRASIL; telephone: ++55 12...

  15. Choosing the Right Database Management Program.

    ERIC Educational Resources Information Center

    Vockell, Edward L.; Kopenec, Donald

    1989-01-01

    Provides a comparison of four database management programs commonly used in schools: AppleWorks, the DOS 3.3 and ProDOS versions of PFS, and MECC's Data Handler. Topics discussed include information storage, spelling checkers, editing functions, search strategies, graphs, printout formats, library applications, and HyperCard. (LRW)

  16. 78 FR 19077 - Forwarding of Asylum Applications to the Department of State

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... removing the mandatory submission of all asylum applications to DOS. See 76 FR 67099 (Oct. 31, 2011). The... information relevant to the adjudication of a particular case or type of claims. By consolidating certain paragraphs, the final rule also removes redundant references to the types of information that DOS may...

  17. Dissolved organic sulfur in streams draining forested catchments in southern China.

    PubMed

    Wang, Zhanyi; Zhang, Xiaoshan; Wang, Zhangwei; Zhang, Yi; Li, Bingwen; Vogt, Rolf

    2012-01-01

    Dissolved organic sulfur (DOS) is an important fraction for sulfur mobilization in ecosystem. In this work stream waters were sampled in 25 forested sites in southern China to study the dissolved sulfur fractions. Dissolved sulfur was fractionated into dissolved organic sulfur (DOS) and inorganic sulfate (SO4(2-)) for 95 stream water samples. The results showed that the concentration of DOS ranged from 0 to 13.1 mg/L (average 1.3 mg/L) in all the streams. High concentrations of DOS in stream waters were found in the sites with high concentrations of sulfate. DOS constituted less than 60.1% of dissolved sulfur (average 17.9%). Statistical analysis showed that DOS concentration was correlated with SO4(2-) in streams waters and total sulfur in surface layer soils. The results also showed that DOS concentration in stream waters had a seasonal variation, but no trends were found with it. The implication was that the long term sulfur deposition had led the increase of the concentration and fraction of DOS in stream waters in acid rain prevailing regions

  18. Break up a File with EDLIN.

    ERIC Educational Resources Information Center

    Koga, James S.

    Online searchers who download large amounts of data into a single ASCII file often have difficulty fitting that large file into their MS-DOS word processors for post-processing. This paper gives step-by-step instructions for using EDLIN, a text editor for DOS files, to break up a large downloaded file into smaller files. (1 reference) (Author/EW)

  19. 75 FR 52581 - Notice of Meeting and Closed Meeting of the Cultural Property Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE [Public Notice 7105; Greece Docket No. DOS-2010-0339; Colombia Docket No. DOS-2010-0340] Notice of Meeting and Closed Meeting of the Cultural Property Advisory Committee There will be a meeting of the...

  20. Measuring Student Learning in Social Justice Courses: The Diversity and Oppression Scale

    ERIC Educational Resources Information Center

    Windsor, Liliane Cambraia; Shorkey, Clay; Battle, DuWayne

    2015-01-01

    The Diversity and Oppression Scale (DOS) is a standardized instrument measuring self-reported student learning about diversity and oppression based on requirements of the Council on Social Work Education. DOS was tested with social work students in 2 major North American universities. Factor structure was examined using exploratory factor analysis…

  1. Dissolved organic sulfur in streams draining forested catchments in southern China.

    PubMed

    Wang, Zhanyi; Zhang, Xiaoshan; Wang, Zhangwei; Zhang, Yi; Li, Bingwen; Vogt, Rolf

    2012-01-01

    Dissolved organic sulfur (DOS) is an important fraction for sulfur mobilization in ecosystem. In this work stream waters were sampled in 25 forested sites in southern China to study the dissolved sulfur fractions. Dissolved sulfur was fractionated into dissolved organic sulfur (DOS) and inorganic sulfate (SO4(2-)) for 95 stream water samples. The results showed that the concentration of DOS ranged from 0 to 13.1 mg/L (average 1.3 mg/L) in all the streams. High concentrations of DOS in stream waters were found in the sites with high concentrations of sulfate. DOS constituted less than 60.1% of dissolved sulfur (average 17.9%). Statistical analysis showed that DOS concentration was correlated with SO4(2-) in streams waters and total sulfur in surface layer soils. The results also showed that DOS concentration in stream waters had a seasonal variation, but no trends were found with it. The implication was that the long term sulfur deposition had led the increase of the concentration and fraction of DOS in stream waters in acid rain prevailing regions PMID:22894106

  2. Yours, Mine or Ours: What Counts as Innovation?

    ERIC Educational Resources Information Center

    Cooksey, Ray W.

    2011-01-01

    In this paper, I argue that research and development organizations (R&DOs) have particular perspectives on what counts as an innovation whereas the potential adopting users usually have quite different often diverse perspectives. If these "worldviews" do not overlap or speak to each other, then what R&DOs consider innovative might constitute a…

  3. MLJ Computer Corner.

    ERIC Educational Resources Information Center

    Brink, Dan

    1986-01-01

    A general technique for customizing computer printers (with the MS-DOS or PC-DOS software) to the special needs of foreign language professionals is described, and examples are presented. This "detour" technique can be used to turn the printer into a typewriter and send character sequences to the printer. (CB)

  4. 32 CFR Appendix B to Part 197 - Procedures for Historical Researchers Permanently Assigned Within the Executive Branch Working on...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CIA) and National Security Council (NSC) are not signatories to the Agreement. Authorization for... from the CIA, NSC, Department of State (DoS), and any other non-DoD Agency whose classified information... historian, authorization for access must be obtained from the CIA, NSC, DoS, and any other non-DoD...

  5. 32 CFR Appendix B to Part 197 - Procedures for Historical Researchers Permanently Assigned Within the Executive Branch Working on...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CIA) and National Security Council (NSC) are not signatories to the Agreement. Authorization for... from the CIA, NSC, Department of State (DoS), and any other non-DoD Agency whose classified information... historian, authorization for access must be obtained from the CIA, NSC, DoS, and any other non-DoD...

  6. 32 CFR Appendix B to Part 197 - Procedures for Historical Researchers Permanently Assigned Within the Executive Branch Working on...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CIA) and National Security Council (NSC) are not signatories to the Agreement. Authorization for... from the CIA, NSC, Department of State (DoS), and any other non-DoD Agency whose classified information... historian, authorization for access must be obtained from the CIA, NSC, DoS, and any other non-DoD...

  7. 32 CFR Appendix B to Part 197 - Procedures for Historical Researchers Permanently Assigned Within the Executive Branch Working on...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CIA) and National Security Council (NSC) are not signatories to the Agreement. Authorization for... from the CIA, NSC, Department of State (DoS), and any other non-DoD Agency whose classified information... historian, authorization for access must be obtained from the CIA, NSC, DoS, and any other non-DoD...

  8. 32 CFR Appendix B to Part 197 - Procedures for Historical Researchers Permanently Assigned Within the Executive Branch Working on...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CIA) and National Security Council (NSC) are not signatories to the Agreement. Authorization for... from the CIA, NSC, Department of State (DoS), and any other non-DoD Agency whose classified information... historian, authorization for access must be obtained from the CIA, NSC, DoS, and any other non-DoD...

  9. IBM Compatibility.

    ERIC Educational Resources Information Center

    Miller, Michael J.; McMillan, Tom

    1984-01-01

    Defines in detail the three levels of IBM compatibility--operational, data, and MS-DOS--and also examines 16-bit microprocessors and the MS-DOS operating system, both of which play key roles in determining whether a given machine will run IBM software. (MBR)

  10. Microcomputer Software for Online Information Management: An Overview.

    ERIC Educational Resources Information Center

    Nieuwenhuysen, Paul

    1988-01-01

    Summary of the findings of a critical overview of more than 200 microcomputer programs using PC-DOS/MS-DOS for online information management discusses software for telecommunications, conversion/reformatting, storage and retrieval of text information, and word processing. (6 references) (MES)

  11. A Bibliography of Text Information Management Software for IBM Microcomputers and Compatibles.

    ERIC Educational Resources Information Center

    Nieuwenhuysen, Paul

    1988-01-01

    This bibliography lists 754 books and articles which focus on programs that can run on IBM microcomputers and compatibles using PC DOS/MS DOS, and that can be used in online information and documentation work. An index lists the software packages alphabetically by title and references them to the main entries, which are listed by author. (CLB)

  12. RESPSYST: An Interactive Microcomputer Program for Education.

    ERIC Educational Resources Information Center

    Boyle, Joseph

    1985-01-01

    RESPSYST is a computer program (written in BASICA and using MS-DOS/PC-DOS microcomputers) incorporating more than 20 of the factors that determine gas transport by the cardio-respiratory system. The five-part program discusses most of these factors, provides several question/answer sections, and relies heavily on graphics to demonstrate…

  13. Effect of oxygen partial pressure on the density of states of amorphous InGaZnO thin-film transistors

    NASA Astrophysics Data System (ADS)

    Li, Jun; Huang, Chuan-Xin; Zhu, Wen-Qing; Zhang, Jian-Hua; Jiang, Xue-Yin; Zhang, Zhi-Lin; Li, Xi-Feng

    2016-10-01

    The thin-film transistors (TFTs) with InGaZnO active layer with different oxygen partial pressures are fabricated by radio frequency sputtering. The influence of the oxygen partial pressure on the density of states (DOS) for InGaZnO-TFT is investigated by using temperature-dependent field-effect measurements. It indicates that the DOS become smaller with increasing oxygen partial pressure. The results are verified by the threshold voltage shift of InGaZnO-TFT with different oxygen partial pressures. The trend of the variation of DOS is consistent with that of the threshold voltage shift for InGaZnO-TFT. Thus, the gate bias instability is attributed to the charge trapping mechanism based on DOS. Therefore, this work offered a brief and accurate method to calculate DOS for demonstrating the bias stability of transistor.

  14. If Your Child Learns in Two Languages: A Parent's Guide for Improving Educational Opportunities for Children Acquiring English as a Second Language = Si su nino aprende en dos idiomes: Una guia para que las familias sepan como mejorar las oportunidades educativas de los ninos que adquieren el ingles como segunda lengua = Neu lon Ban Hoc Bang Hai Thu Tieng: Chi-nam cua phu-huynh de cai tien co hoi hoc van cua con em dang hoc Anh van nhu sinh ngu thu hai.

    ERIC Educational Resources Information Center

    Zelasko, Nancy; Antunez, Beth

    This guide, in English, Spanish, and Vietnamese, aims to inform parents of students who have learned or are learning English as a Second Language about appropriate approaches for educating children so that they can work with schools to ensure a high quality education for their children. The emphasis is on explaining the laws, schools, and research…

  15. Geostatistical mapping of leakance in a regional aquitard, Oak Ridges Moraine area, Ontario, Canada

    NASA Astrophysics Data System (ADS)

    Desbarats, A. J.; Hinton, M. J.; Logan, C. E.; Sharpe, D. R.

    2001-01-01

    'imperméable, dans le but d'évaluer l'importance relative des processus d'alimentation des aquifères inférieurs. À partir d'une vaste base de données constituée par les mesures faites dans les puits et contenant des informations à la fois certaines et incertaines, la méthode de simulation par indicateur séquentiel est utilisée pour créer des cartes d'épaisseur de l'imperméable et de probabilité d'existence des fenêtres. Ces cartes peuvent être utilisées pour mettre en évidence les aquifères de chenaux et pour identifier les zones potentielles de recharge des aquifères inférieurs. Les conductivités hydrauliques sont modélisées à partir de données clairsemées en supposant que leur gamme de corrélation est beaucoup plus faible que le pas de la grille. La drainance à l'échelle des blocs est obtenue par accroissement du niveau d'échelle des valeurs nodales basé sur les champs de conductivité simulée et des épaisseurs. À partir de l'hypothèse d'écoulement dans l'aquifère, l'accroissement d'échelle est réalisé en faisant une moyenne arithmétique spatiale. Des histogrammes et des cartes de drainance avec accroissement d'échelle montrent que les hétérogénéités associées aux fenêtres dans l'imperméable constituent l'effet le plus important dans l'organisation des écoulements souterrains régionaux. Resumen. El Till de Newmarket forma un acuitardo de extensión regional que separa dos sistemas acuíferos principales en la zona de Greater Toronto (Canadá). El till está horadado, y a veces completamente erosionado, por una red de canales rellenos de arena y grava. Estos constituyen acuíferos productivos y, localmente, conexiones de alta permeabilidad entre sistemas acuíferos. El goteo a través del till puede ser fundamental en ciertos lugares. Este estudio investiga la variabilidad espacial del goteo desde el acuitardo con el fin de establecer la importancia relativa de los procesos de recarga hacia los acuíferos inferiores. Se ha

  16. Operational tools and applications of EO satellite data to retrieve surface fluxes in semi-arid countries

    NASA Astrophysics Data System (ADS)

    Tanguy, Maliko

    ítulo 4), se evalúa la fiabilidad de una nueva parametrización para estimar el flujo de calor en el suelo (G) con el fin de ser utilizado en métodos de estimación de la evapotranspiración (ET) usando datos de teledetección. La parametrización de G se optimiza usando datos de flujo de energía obtenido durante las campañas del proyecto AMMA, y muestra buenos resultados y una mejora de las estimaciones del flujo de calor sensible (H) y de ET cuando se utiliza conjuntamente con el método del triángulo (Jiang & Islam, 2001). En una segunda parte (Capítulo 5), el método del triángulo se compara con valores de ET estimado por un modelo de superficie terrestre (JULES). Se intenta calibrar JULES usando el método del triángulo mediante simulaciones de Monte Carlo, pero los dos métodos muestran resultados muy diferentes, indicando que se necesita tareas de comparación profundizadas para poder evaluar la eficacia de estos modelos (de superficie terrestre y basados en la teledetección) para estimar los flujos de energía a la superficie. El capítulo 6 presenta un conjunto de ejemplos de aplicaciones operacionales para estimar los flujos de superficie usando datos de teledetección. El primer ejemplo consiste en el estudio de la evolución temporal de mapas de ET en África occidental bajo la influencia del monzón africano. En el segundo ejemplo, se aplica la nueva parametrización de G descrita en el capítulo 4 para calcular y analizar la evolución a largo plazo (2000-2009) de los componentes del balance de energía a la superficie, G, H y ET, en diferentes puntos de la cuenca del río Segura (Sureste español) utilizando datos del sensor MODIS-Terra (temperatura superficial y NDVI). La distribución temporal y espacial de ET revela diferentes controles sobre ET. En el último ejemplo, datos de temperatura superficial del mar del sensor MODIS-Aqua se utilizaron para validar un modelo matemático para calcular los flujos superficiales de una laguna costera del

  17. Geostatistical mapping of leakance in a regional aquitard, Oak Ridges Moraine area, Ontario, Canada

    NASA Astrophysics Data System (ADS)

    Desbarats, A. J.; Hinton, M. J.; Logan, C. E.; Sharpe, D. R.

    2001-01-01

    'imperméable, dans le but d'évaluer l'importance relative des processus d'alimentation des aquifères inférieurs. À partir d'une vaste base de données constituée par les mesures faites dans les puits et contenant des informations à la fois certaines et incertaines, la méthode de simulation par indicateur séquentiel est utilisée pour créer des cartes d'épaisseur de l'imperméable et de probabilité d'existence des fenêtres. Ces cartes peuvent être utilisées pour mettre en évidence les aquifères de chenaux et pour identifier les zones potentielles de recharge des aquifères inférieurs. Les conductivités hydrauliques sont modélisées à partir de données clairsemées en supposant que leur gamme de corrélation est beaucoup plus faible que le pas de la grille. La drainance à l'échelle des blocs est obtenue par accroissement du niveau d'échelle des valeurs nodales basé sur les champs de conductivité simulée et des épaisseurs. À partir de l'hypothèse d'écoulement dans l'aquifère, l'accroissement d'échelle est réalisé en faisant une moyenne arithmétique spatiale. Des histogrammes et des cartes de drainance avec accroissement d'échelle montrent que les hétérogénéités associées aux fenêtres dans l'imperméable constituent l'effet le plus important dans l'organisation des écoulements souterrains régionaux. Resumen. El Till de Newmarket forma un acuitardo de extensión regional que separa dos sistemas acuíferos principales en la zona de Greater Toronto (Canadá). El till está horadado, y a veces completamente erosionado, por una red de canales rellenos de arena y grava. Estos constituyen acuíferos productivos y, localmente, conexiones de alta permeabilidad entre sistemas acuíferos. El goteo a través del till puede ser fundamental en ciertos lugares. Este estudio investiga la variabilidad espacial del goteo desde el acuitardo con el fin de establecer la importancia relativa de los procesos de recarga hacia los acuíferos inferiores. Se ha

  18. Photoelectric probing of the interfacial trap density-of-states in ZnO nanowire field-effect transistors.

    PubMed

    Raza, Syed Raza Ali; Lee, Young Tack; Chang, Youn-Gyoung; Jeon, Pyo Jin; Kim, Jae Hoon; Ha, Ryong; Choi, Heon-Jin; Im, Seongil

    2013-02-28

    We have fabricated transparent top-gate ZnO nanowire (NW) field effect transistors (FETs) on glass and measured their trap density-of-states (DOS) at the dielectric/ZnO NW interface with monochromatic photon beams during their operation. Our photon-probe method showed clear signatures of charge trap DOS at the interface, located near 2.3, 2.7, and 2.9 eV below the conduction band edge. The DOS information was utilized for the photo-detecting application of our transparent NW-FETs, which demonstrated fast and sensitive photo-detection of visible lights.

  19. Diversity oriented synthesis for novel anti-malarials.

    PubMed

    Bathula, Chandramohan; Singh, Shailja; Sen, Subhabrata

    2015-12-01

    Malaria a global pandemic has engulfed nearly 0.63 million people globally. It is high time that a cure for malaria is required to stop its ever increasing menace. Our commentary discusses the advent and contribution of diversity oriented synthesis (DOS) in the drug discovery efforts towards developing cure for malaria. DOS based on chemical genetics focusses on design and synthesis of molecular libraries which covers large tracts of biologically relevant chemical space. Herein we will discuss the applications, advantages, disadvantages and future directions of DOS with respect to malaria.

  20. Influence of fishing technique on organochlorine pesticide accumulation in fish and its possible human health risk in the Republic of Bénin.

    PubMed

    Yehouenou A Pazou, Elisabeth; Azehoun, Judicaël P; Ahoyo, Theodora; Aléodjrodo, Patrick Edorh; van Straalen, Nico M; van Gestel, Cornelis A M

    2013-09-01

    In Bénin different techniques are used for large-scale commercial fishing, Acadjas (enclosures constructed in the river) and Whédos (holes made in the river banks). This study aimed at assessing the extent of contamination related to these fishing techniques. Fish contained residues of DDT and its metabolites, α-endosulfan, dieldrin, aldrin, endrin and lindane. Pesticide levels were similar in fish from Acadjas and Whédos, except for higher α-endosulfan levels in fish from the Whédos. Comparing pesticide intake levels through fish consumption with tolerable daily intake levels showed that in all cases risk for human health is low.

  1. Vibrational Properties of Nanograins and Interfaces in Nanocrystalline Materials

    SciTech Connect

    Stankov, S.; Sergueev, I.; Chumakov, A. I.; Rueffer, R.; Yue, Y. Z.; Hu, L.; Miglierini, M.; Sepiol, B.; Svec, P.

    2008-06-13

    The vibrational dynamics of nanocrystalline Fe{sub 90}Zr{sub 7}B{sub 3} was studied at various phases of crystallization. The density of phonon states (DOS) of the nanograins was separated from that of the interfaces for a wide range of grain sizes and interface thicknesses. The DOS of the nanograins does not vary with their size and down to 2 nm grains still closely resembles that of the bulk. The anomalous enhancement of the phonon states at low and high energies originates from the DOS of the interfaces and scales linearly to their atomic fraction.

  2. Disorder-induced gap in the normal density of states of the organic superconductor κ-(BEDT-TTF)2Cu[N(CN)2]Br.

    PubMed

    Diehl, Sandra; Methfessel, Torsten; Tutsch, Ulrich; Müller, Jens; Lang, Michael; Huth, Michael; Jourdan, Martin; Elmers, Hans-Joachim

    2015-07-01

    The local density of states (DOS) of the organic superconductor κ-(BEDT-TTF)2Cu[N(CN)2]Br, measured by scanning tunneling spectroscopy on in situ cleaved surfaces, reveals a logarithmic suppression near the Fermi edge persisting above the critical temperature T(c). The experimentally observed suppression of the DOS is in excellent agreement with a soft Hubbard gap as predicted by the Anderson-Hubbard model for systems with disorder. The electronic disorder also explains the diminished coherence peaks of the quasi-particle DOS below T(c).

  3. Sore Throat? Know When To Call the Doctor

    MedlinePlus

    ... be. According to Phillip L. Accardo, DO, an osteopathic physician from Lee’s Summit, Mo., the key to treating ... does not support this functionality. About Osteopathic Medicine Osteopathic physicians, or DOs, are fully licensed to prescribe medicine ...

  4. 8. General oblique view: east side of south end, from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. General oblique view: east side of south end, from the Dos Hermanos Highway Bridge - Puente Guillermo Esteves, Spanning San Antonio Channel at PR-25 (Juan Ponce de Leon Avenue), San Juan, San Juan Municipio, PR

  5. Doctor of osteopathic medicine

    MedlinePlus

    ... within the specialty area and passing the board certification exams. DOs practice in all specialties of medicine, ... 2014;114:200-212. Kuchera ML. Applying osteopathic principles to formulate treatment for patients with chronic pain. ...

  6. Ensuring Safe Use of Contact Lens Solution

    MedlinePlus

    ... For Consumers Consumer Updates Ensuring Safe Use of Contact Lens Solution Share Tweet Linkedin Pin it More ... back to top Dos and Don'ts for Contact Lens Wearers DO: Always wash your hands before ...

  7. 76 FR 7511 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Model ERJ 170...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    ... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will.... Brigadeiro Faria Lima, 2170--Putim-- 12227-901 S o Jose dos Campos--SP--BRASIL; telephone +55 12 3927-5852...

  8. 76 FR 2279 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Model ERJ 170 and ERJ...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-13

    ... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will.... Brigadeiro Faria Lima, 2170-Putim- 12227-901 S o Jose dos Campos-SP--BRASIL; telephone +55 12 3927- 5852...

  9. 75 FR 9814 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Model ERJ 190-100 STD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic.... Brigadeiro Faria Lima, 2170--Putim-- 12227-901 S o Jose dos Campos--SP--BRASIL; telephone: +55 12...

  10. "The World in a Drop of Water": The Feminist Vision of Patricia Howell.

    ERIC Educational Resources Information Center

    Holmlund, Chris

    1993-01-01

    Discusses two films ("Dos veces mujer" and "Intima raiz") of Patricia Howell. Demonstrates how thoroughly the feminist themes Howell's films weave together around motherhood are inflected by the specific Latin American and Costa Rican contexts in which she works. (RS)

  11. 77 FR 39320 - Suggestions for Environmental Cooperation Pursuant to the United States-Singapore Memorandum of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ... comment on this notice by going to: http://www.regulations.gov/#!home and searching on docket number: DOS...; (2) participating in regional initiatives on environmentally sustainable cities and...

  12. Microscopist`s aide: A computer program written to analyze TEM micrographs

    SciTech Connect

    Reinhart, D.E.; Gelles, D.S.

    1996-04-01

    A computer program has been rewritten in DOS Basic allowing current state-of-the-art computer equipment to be used for quantitative measurement of microstructural features such as voids, dislocations, and precipitates.

  13. 48 CFR 602.101-70 - DOSAR definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Agency. Department or DOS means the Department of State, including all of its activities wherever located... within its specific geographic area as assigned by the Office of Logistics Operations. There are...

  14. Computer Viruses: An Overview.

    ERIC Educational Resources Information Center

    Marmion, Dan

    1990-01-01

    Discusses the early history and current proliferation of computer viruses that occur on Macintosh and DOS personal computers, mentions virus detection programs, and offers suggestions for how libraries can protect themselves and their users from damage by computer viruses. (LRW)

  15. An Expert System for Identification of Minerals in Thin Section.

    ERIC Educational Resources Information Center

    Donahoe, James Louis; And Others

    1989-01-01

    Discusses a computer database which includes optical properties of 142 minerals. Uses fuzzy logic to identify minerals from incomplete and imprecise information. Written in Turbo PASCAL for MS-DOS with 128K. (MVL)

  16. Density of photon states in dye-doped chiral nematic liquid crystal cells in the presence of losses and gain.

    PubMed

    Mavrogordatos, Th K; Morris, S M; Castles, F; Hands, P J W; Ford, A D; Coles, H J; Wilkinson, T D

    2012-07-01

    We calculate the density of photon states (DOS) of the normal modes in dye-doped chiral nematic liquid crystal (LC) cells in the presence of various loss mechanisms. Losses and gain are incorporated into the transmission characteristics through the introduction of a small imaginary part in the dielectric constant perpendicular and along the director, for which we assume no frequency dispersion. Theoretical results are presented on the DOS in the region of the photonic band gap for a range of values of the loss coefficient and different values of the optical anisotropy. The obtained values of the DOS at the photonic band gap edges predict a reversal of the dominant modes in the structure. Our results are found to be in good agreement with the experimentally obtained excitation thresholds in chiral nematic LC lasers. The behavior of the DOS is also discussed for amplifying LC cells providing additional insight to the lasing mechanism of these structures.

  17. 48 CFR 602.101-70 - DOSAR definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Agency. Department or DOS means the Department of State, including all of its activities wherever located... within its specific geographic area as assigned by the Office of Logistics Operations. There are...

  18. Computers in Schools.

    ERIC Educational Resources Information Center

    Moore, John W.; Moore, Elizabeth A.

    1988-01-01

    Surveys the types of computers being used in high school and university chemistry courses. Identifies types of hardware found on Apple and MS-DOS computers. Makes recommendations for the upgrading of current equipment. (ML)

  19. Microcomputer Decisions for the 1990s [and] Apple's Macintosh: A Viable Choice.

    ERIC Educational Resources Information Center

    Grosch, Audrey N.

    1989-01-01

    Discussion of the factors that should be considered when purchasing or upgrading a microcomputer focuses on the MS-DOS and OS/2 operating systems. Macintosh purchasing decisions are discussed in a sidebar. A glossary is provided. (CLB)

  20. Writing in Concert: A New Generation of Networked Software.

    ERIC Educational Resources Information Center

    Theisen, Emmy

    1992-01-01

    Describes "Let's Write!" a writing package for the MS-DOS network which combines five software programs to define a new collaborative dynamic for writing, reading, and thinking on computer networks. (SR)

  1. Parenting

    MedlinePlus

    ... parents, people are always ready to offer advice. Parenting tips, parents' survival guides, dos, don'ts, shoulds ... right" way to be a good parent. Good parenting includes Keeping your child safe Showing affection and ...

  2. Privileged structures: efficient chemical "navigators" toward unexplored biologically relevant chemical spaces.

    PubMed

    Kim, Jonghoon; Kim, Heejun; Park, Seung Bum

    2014-10-22

    In the search for new therapeutic agents for currently incurable diseases, attention has turned to traditionally "undruggable" targets, and collections of drug-like small molecules with high diversity and quality have become a prerequisite for new breakthroughs. To generate such collections, the diversity-oriented synthesis (DOS) strategy was developed, which aims to populate new chemical space with drug-like compounds containing a high degree of molecular diversity. The resulting DOS-derived libraries have been of great value for the discovery of various bioactive small molecules and therapeutic agents, and thus DOS has emerged as an essential tool in chemical biology and drug discovery. However, the key challenge has become how to design and synthesize drug-like small-molecule libraries with improved biological relevancy as well as maximum molecular diversity. This Perspective presents the development of privileged substructure-based DOS (pDOS), an efficient strategy for the construction of polyheterocyclic compound libraries with high biological relevancy. We envisioned the specific interaction of drug-like small molecules with certain biopolymers via the incorporation of privileged substructures into polyheterocyclic core skeletons. The importance of privileged substructures such as benzopyran, pyrimidine, and oxopiperazine in rigid skeletons was clearly demonstrated through the discovery of bioactive small molecules and the subsequent identification of appropriate target biomolecule using a method called "fluorescence difference in two-dimensional gel electrophoresis". Focusing on examples of pDOS-derived bioactive compounds with exceptional specificity, we discuss the capability of privileged structures to serve as chemical "navigators" toward biologically relevant chemical spaces. We also provide an outlook on chemical biology research and drug discovery using biologically relevant compound libraries constructed by pDOS, biology-oriented synthesis, or

  3. Simulium (Inaequalium) marins, a new species of black fly (Diptera: Simuliidae) from inselbergs in Brazil.

    PubMed

    Pepinelli, Mateus; Hamada, Neusa; Currie, Douglas C

    2009-08-01

    A new species of black fly, Simulium (Inaequalium) marins (Diptera: Simuliidae), is described based on the male, female, pupa and larva. This new species was collected from two localities: a small stream on the Pico dos Marins, a high mountain with granite outcrops in Piquete County, state of São Paulo, and in a small stream in the Serra dos Orgãos National Park, state of Rio de Janeiro, Brazil.

  4. Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β.

    PubMed

    Wang, Yikai; Wach, Jean-Yves; Sheehan, Patrick; Zhong, Cheng; Zhan, Chenyang; Harris, Richard; Almo, Steven C; Bishop, Joshua; Haggarty, Stephen J; Ramek, Alexander; Berry, Kayla N; O'Herin, Conor; Koehler, Angela N; Hung, Alvin W; Young, Damian W

    2016-09-01

    Traditional fragment-based drug discovery (FBDD) relies heavily on structural analysis of the hits bound to their targets. Herein, we present a complementary approach based on diversity-oriented synthesis (DOS). A DOS-based fragment collection was able to produce initial hit compounds against the target GSK3β, allow the systematic synthesis of related fragment analogues to explore fragment-level structure-activity relationship, and finally lead to the synthesis of a more potent compound. PMID:27660690

  5. Quantification of joint inflammation in rheumatoid arthritis by time-resolved diffuse optical spectroscopy and tracer kinetic modeling

    NASA Astrophysics Data System (ADS)

    Ioussoufovitch, Seva; Morrison, Laura B.; Lee, Ting-Yim; St. Lawrence, Keith; Diop, Mamadou

    2015-03-01

    Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation, which can cause progressive joint damage and disability. Diffuse optical spectroscopy (DOS) and imaging have the potential to become potent monitoring tools for RA. We devised a method that combined time-resolved DOS and tracer kinetics modeling to rapidly and reliably quantify blood flow in the joint. Preliminary results obtained from two animals show that the technique can detect joint inflammation as early as 5 days after onset.

  6. 77 FR 24425 - Airworthiness Directives; Empresa Brasileria de Aeronáutica S.A. (EMBRAER) Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ... Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska, and (4) Will.... Brigadeiro Faria Lima, 2170, S o Jos dos Campos--SP, CEP: 12227-901--P.O. Box 36/2, BRASIL; fax ++55 12 3927... dos Campos--SP, CEP: 12227-901--P.O. Box 36/2, BRASIL; fax ++55 12 3927- 2619; email...

  7. Low-threshold and high efficiency lasing upon band-edge excitation in a cholesteric liquid crystal

    NASA Astrophysics Data System (ADS)

    Matsuhisa, Yuko; Huang, Yuhua; Zhou, Ying; Wu, Shin-Tson; Ozaki, Ryotaro; Takao, Yuuki; Fujii, Akihiko; Ozaki, Masanori

    2007-02-01

    A low threshold and high efficiency laser based on dye-doped cholesteric liquid crystals (CLCs) is demonstrated using an input excitation with the same handedness of circular polarization as the helical structure of the sample at the shorter wavelength band edge of the reflection band. The responsible mechanism originates from the dramatic increase of the optical density of state (DOS) at the band edges. The calculated DOS of the CLC system confirms the authors' experimental results.

  8. Using multi-country household surveys to understand who provides reproductive and maternal health services in low- and middle-income countries: a critical appraisal of the Demographic and Health Surveys

    PubMed Central

    Footman, K; Benova, L; Goodman, C; Macleod, D; Lynch, C A; Penn-Kekana, L; Campbell, O M R

    2015-01-01

    èmes tels que l'amalgame d'options de réponses, les données sur les prestataires du public par rapport à ceux du privé, l'incohérence dans le codage et l'obtention de métadonnées. Plus de collecte systématique et standardisée des données aiderait les comparaisons internationales des progrès vers une meilleure protection financière et nous permettra de mieux caractériser les incitations et la nature commerciale des différents prestataires. Objetivo Las Encuestas Demográficas y de Salud (EDS) son una fuente de datos vitales para el análisis comparativo entre países. Este artículo es parte de un grupo de análisis que evalúan los tipos de proveedores de atención a la salud reproductiva y materna que están siendo utilizados en 57 países. Examinamos algunos de los retos encontrados al utilizar datos de EDS con este propósito, presentamos la clasificación de proveedores que hemos usado, y proveemos recomendaciones para permitir una comparación más detallada y más precisa de la prestación de servicios sanitarios en diferentes países. Métodos Hemos utilizado datos de las EDS más recientes, entre el 2000 y 2012; 57 países tenían datos sobre planeación familiar y proveedores de servicios durante el parto y 47 países tenían datos sobre cuidados prenatales. Cada opción posible de respuesta en los 57 países fue listada y categorizada. Después se desarrolló una clasificación para agrupar las opciones de respuesta según proveedor, siguiendo dos dimensiones clave: naturaleza clínica y afán de lucro. Resultados Hemos clasificado los diferentes tipos de proveedores de cuidados sanitarios en salud materna y reproductiva, y a los individuos que ofrecían los servicios. Los retos documentados durante este proceso fueron las limitaciones inherentes a los datos en las encuestas realizadas en los hogares basados en las auto-respuestas de los encuestados; fusión de las opciones de respuesta en el cuestionario o durante la etapa de procesamiento de datos

  9. [Descriptive statistical analysis of the treatment of status epilepticus in a referral hospital].

    PubMed

    Hortigüela-Saeta, M Montesclaros; Conejo-Moreno, David; Gutiérrez-Moreno, Miriam; Gómez-Saiz, Luna

    2015-05-16

    Introduccion. Los estados epilepticos se definen como crisis recurrentes sin recuperacion de la conciencia entre ellas o una sola crisis de mas de 30 minutos. Objetivos. Realizar un analisis descriptivo de los datos mas relevantes de pacientes con estados epilepticos ingresados en la unidad de cuidados intensivos pediatricos (UCIP) y revisar los factores de riesgo asociados a estado epileptico de mal pronostico. Pacientes y metodos. Se estudiaron las variables principales de los pacientes ingresados en la UCIP con estado epileptico de un hospital terciario en un periodo de seis años. Resultados. Se recogieron 68 pacientes (el 55,9%, varones) con una edad media de 3,7 años. La semiologia mas frecuente fue en forma de crisis tonicoclonicas generalizadas (50%). La duracion media de los estados epilepticos fue de 51,44 minutos. Se utilizaron 3,21 farmacos antiepilepticos de media para yugular las crisis, y la media de farmacos utilizados previamente al ingreso en la UCIP fue de 2,37. El farmaco de primera linea mas utilizado fue el diacepam (83,8%) rectal (75%), seguido del diacepam (52,9%) por via intravenosa en segundo lugar, y la fenitoina fue el farmaco mas utilizado como tercera linea. La causa mas frecuente de estado epileptico fue padecer epilepsia previa (33,9%), y el sindrome de Dravet fue la etiologia epileptica mas frecuente. Conclusiones. El tratamiento de los estados epilepticos es complejo y exige un manejo multidisciplinar e individualizado. Es necesaria la elaboracion y revision de protocolos y guias clinicas para un adecuado manejo de estos pacientes.

  10. [METHODS OF EVALUATION OF MUSCLE MASS: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS].

    PubMed

    Moreira, Osvaldo Costa; de Oliveira, Cláudia Eliza Patrocínio; Candia-Luján, Ramón; Romero-Pérez, Ena Monserrat; de Paz Fernandez, José Antonio

    2015-09-01

    Introducción: en los últimos años las investigaciones sobre la masa muscular han cobrado popularidad por su relación con la salud. Así, la medición precisa de la masa muscular puede tener aplicación clínica, ya que puede interferir en el diagnóstico y prescripción del tratamiento medicamentoso o no medicamentoso. Objetivo: realizar una revisión sistemática de los métodos más utilizados para la evaluación de la masa muscular en ensayos controlados aleatorios, con sus ventajas y desventajas. Método: se llevó a cabo una búsqueda en las bases de datos Pubmed, Web of Science y Scopus, con las palabras muscle mass, measurement, assessment y evaluation, combinadas de esta manera: “muscle mass” AND (measurement OR assessment OR evaluation). Resultados: 23 estudios fueron recuperados y analizados, todos ellos en inglés. El 69,56% utilizaron solamente un método para la cuantificación de la masa muscular; el 69,57% utilizaron la doble absorciometría de rayos X (DXA); en el 45,46% el tipo de medida utilizado fue la masa corporal total libre de grasa; y el 51,61% eligieron el cuerpo total como sitio de medida. Conclusiones: en los ensayos controlados aleatorios analizados la mayor parte utilizó apenas un método de evaluación, siendo la DXA el método más empleado, la masa corporal total libre de grasa el tipo de medida más utilizado y el cuerpo total el sitio de medida más común.

  11. Energy resolved electrochemical impedance spectroscopy for electronic structure mapping in organic semiconductors

    NASA Astrophysics Data System (ADS)

    Nádaždy, V.; Schauer, F.; Gmucová, K.

    2014-10-01

    We introduce an energy resolved electrochemical impedance spectroscopy method to map the electronic density of states (DOS) in organic semiconductor materials. The method consists in measurement of the charge transfer resistance of a semiconductor/electrolyte interface at a frequency where the redox reactions determine the real component of the impedance. The charge transfer resistance value provides direct information about the electronic DOS at the energy given by the electrochemical potential of the electrolyte, which can be adjusted using an external voltage. A simple theory for experimental data evaluation is proposed, along with an explanation of the corresponding experimental conditions. The method allows mapping over unprecedentedly wide energy and DOS ranges. Also, important DOS parameters can be determined directly from the raw experimental data without the lengthy analysis required in other techniques. The potential of the proposed method is illustrated by tracing weak bond defect states induced by ultraviolet treatment above the highest occupied molecular orbital in a prototypical σ-conjugated polymer, poly[methyl(phenyl)silylene]. The results agree well with those of our previous DOS reconstruction by post-transient space-charge-limited-current spectroscopy, which was, however, limited to a narrow energy range. In addition, good agreement of the DOS values measured on two common π-conjugated organic polymer semiconductors, polyphenylene vinylene and poly(3-hexylthiophene), with the rather rare previously published data demonstrate the accuracy of the proposed method.

  12. Mutational biosynthesis of neomycin analogs by a mutant of neomycin-producing Streptomyces fradiae.

    PubMed

    Shi, Guanying; Zhang, Xingang; Wu, Lang; Xie, Jin; Tao, Ke; Hou, Taiping

    2011-11-01

    Neomycin, produced by Streptomyces fradiae, has been widely used for the treatment of bacterial infections in clinical and agricultural applications. In this study, a neomycin nonproducing mutant of S. fradiae was obtained by gene disruption technique for mutational biosynthesis. A crucial gene neoC (neo7) which encodes 2-deoxystreptamine (2-DOS) synthases was disrupted. The mutant could resume producing neomycin in the presence of 2-DOS. Salen derivatives of 2-DOS were synthesized and individually added to cultures of the mutant. Antibacterial activity of the mutasynthesis products against Staphylococcus aureus and four plant pathogenic bacteria (Pseudomonas solanacarum, Erwinia carotovora, Xanthomonas oryzae, and Xanthomonas campestris) was detected quantitatively by Oxford cup method. It is suggested that all 2-DOS derivatives were incorporated by the mutant into new active neomycin analogs except for 2-DOS derivative 2d ((1R,2r,3S,4R,6S)-4,6-bis((E)-3,5-di-tert-butyl-2-hydroxybenzylideneamino)cyclohexane-1,2,3-triol). Neomycin analogs produced by feeding 2-DOS derivative 2a ((1R,2r,3S,4R,6S)-4,6-bis((E)-2 hydroxybenzylideneamino)cyclohexane-1,2,3-triol) to cultures of the mutant displayed a similar antibacterial activity with neomycin produced by wild strain.

  13. Energy resolved electrochemical impedance spectroscopy for electronic structure mapping in organic semiconductors

    SciTech Connect

    Nádaždy, V. Gmucová, K.; Schauer, F.

    2014-10-06

    We introduce an energy resolved electrochemical impedance spectroscopy method to map the electronic density of states (DOS) in organic semiconductor materials. The method consists in measurement of the charge transfer resistance of a semiconductor/electrolyte interface at a frequency where the redox reactions determine the real component of the impedance. The charge transfer resistance value provides direct information about the electronic DOS at the energy given by the electrochemical potential of the electrolyte, which can be adjusted using an external voltage. A simple theory for experimental data evaluation is proposed, along with an explanation of the corresponding experimental conditions. The method allows mapping over unprecedentedly wide energy and DOS ranges. Also, important DOS parameters can be determined directly from the raw experimental data without the lengthy analysis required in other techniques. The potential of the proposed method is illustrated by tracing weak bond defect states induced by ultraviolet treatment above the highest occupied molecular orbital in a prototypical σ-conjugated polymer, poly[methyl(phenyl)silylene]. The results agree well with those of our previous DOS reconstruction by post-transient space-charge-limited-current spectroscopy, which was, however, limited to a narrow energy range. In addition, good agreement of the DOS values measured on two common π-conjugated organic polymer semiconductors, polyphenylene vinylene and poly(3-hexylthiophene), with the rather rare previously published data demonstrate the accuracy of the proposed method.

  14. Modeling sediment resuspension-induced DO variation in fine-grained streams.

    PubMed

    Zahraeifard, Vahid; Deng, Zhiqiang

    2012-12-15

    Dissolved Oxygen (DO) levels in streams with nutrient enriched fine-grained sediment are highly affected by sediment resuspension. This paper presents a new model, called VART-DOS model, for simulation of instream DO transport, DO exchanges across water-sediment and water-air interfaces, and DO variation in response to sediment resuspension. The sediment resuspension effect is described by introducing a lumped term as a product of DO concentration and a rate of sediment resuspension-induced DO consumption (Λ). The rate parameter Λ is defined as a nonlinear function of average summer temperature of water and several sediment erosion-related parameters. This is a novel and unique feature of the VART-DOS model. Based on sensitivity analysis, effects of BOD and Sediment Oxygen Demand (SOD) on DO consumption are not so important as compared to sediment resuspension which can cause up to 83% reduction in DO level during high flow. The VART-DOS model was applied to the Lower Amite River in Louisiana, USA to perform continuous simulations of DO fluctuations in the winter month January and the summer month July involving several flood-induced sediment resuspension events. Simulation results indicate that the VART-DOS model is capable of capturing overall variation trends in DO concentration. The Normalized Root Mean Square Error (RMSE) between VART-DOS simulated and observed DO levels was 0. 42 for January and 0.23 for July, demonstrating the efficacy of the VART-DOS model. PMID:23137983

  15. Density of quantum states in quasi-1D layers

    NASA Astrophysics Data System (ADS)

    Kakulia, D.; Tavkhelidze, A.; Gogoberidze, V.; Mebonia, M.

    2016-04-01

    Recently, new quantum effects have been studied in thin nanograting layers. Nanograting on the surface imposes additional boundary conditions on the electron wave function and reduces the density of states (DOS). When the nanograting dimensions are close to the de Broglie wavelength, the DOS reduction is considerable and leads to changes in the layer properties. DOS calculations are challenging to perform and are related to the quantum billiard problem. Performing such calculations requires finding the solutions for the time-independent Schrödinger equation with Dirichlet boundary conditions. Here, we use a numerical method, namely the Method of Auxiliary Sources, which offers significant computational cost reduction relative to other numerical methods. We found the first five eigenfunctions for the nanograting layer and compared them with the corresponding eigenfunctions for a plain layer by calculating the correlation coefficients. Furthermore, the numerical data were used to analyze the DOS reduction. The nanograting is shown to reduce the probability of occupation of a particular quantum state, reducing the integrated DOS by as much as 4.1-fold. This reduction in the DOS leads to considerable changes in the electronic properties.

  16. Código árbol paralelizado para simulaciones astrofísicas. Experimentos de encuentros de galaxias compuestas

    NASA Astrophysics Data System (ADS)

    Viturro, H. R.; Carpintero, D. D.

    Se describe la implementación de un código árbol octal paralelizado desarrollado por los autores. Este código permite la integración del problema de N--cuerpos simultáneamente en varias computadoras (``cluster''), lo que permite desarrollar altas velocidades de cálculo. Se muestran los resultados de algunas integraciones de encuentros entre galaxias de disco con bulbo y halo, generadas mediante algoritmos no utilizados hasta el momento en este campo.

  17. Una técnica para filtrar patrones de fringing

    NASA Astrophysics Data System (ADS)

    Ostrov, P. G.

    Se presenta una nueva técnica para filtrar los patrones de fringing producidos en los CCDs tipo RCA. El método consiste en construir un mapa con los ángulos de inclinación de las franjas en cada punto de la imagen. Este mapa es ulteriormente utilizado para alinear con el patrón de interferencia una ventana estrecha, sobre la que se aplica un filtro de mediana. Este procedimiento permite eliminar la mayor parte del ruido del patrón de fringing sin destruirlo.

  18. [Aetiology and treatment of epilepsy in a series of 1,557 patients].

    PubMed

    Torres-Ferrús, Marta; Toledo, Manuel; González-Cuevas, Montserrat; Seró-Ballesteros, Laia; Santamarina, Esteban; Raspall-Chaure, Miquel; Sueiras-Gil, María; Cambrodí-Masip, Roser; Sarria, Silvana; Álvarez-Sabín, José; Salas-Puig, Javier

    2013-10-01

    Introduccion. La etiologia de la epilepsia es un determinante importante del tratamiento y el pronostico. Los avances diagnosticos y terapeuticos hacen pensar que la distribucion causal, el tratamiento y el pronostico de la poblacion con epilepsia se hayan podido ver modificados. Objetivo. Describir la distribucion sindromica, etiologica y el tratamiento farmacologico en los pacientes con epilepsia. Pacientes y metodos. Estudio descriptivo transversal de pacientes con epilepsia atendidos de manera consecutiva en la consulta de nuestra unidad de epilepsia. Se recogieron datos demograficos, de sindrome, etiologia y tratamiento farmacologico en el momento de la inclusion. Se analizaron los datos de modo conjunto y por grupos de edad. Resultados. Se incluyeron 1.557 pacientes, el 54% varones. El 73% de la muestra tenia una epilepsia focal, que era secundaria a una lesion estructural en el 56%. Las epilepsias generalizadas representaron el 20%. El 5% fue inclasificable. Por edad, la etiologia vascular predominaba en practicamente todos los grupos y su prevalencia aumentaba en relacion con la edad. Los farmacos antiepilepticos mas utilizados fueron acido valproico (29%), levetiracetam (27%) y carbamacepina (20%). El 70% de las epilepsias generalizadas y el 57% de las focales seguian tratamiento en monoterapia. Conclusiones. La prevalencia por grupos de edad fue similar a la descrita en paises desarrollados aunque se observo una menor prevalencia de epilepsias criptogenicas. Mas del 60% de los pacientes seguia monoterapia y el acido valproico fue el mas utilizado.

  19. Cerebral networks of sustained attention and working memory: a functional magnetic resonance imaging study based on the Continuous Performance Test.

    PubMed

    Bartés-Serrallonga, M; Adan, A; Solé-Casals, J; Caldú, X; Falcón, C; Pérez-Pàmies, M; Bargalló, N; Serra-Grabulosa, J M

    2014-04-01

    Introduccion. Uno de los paradigmas mas utilizados en el estudio de la atencion es el Continuous Performance Test (CPT). La version de pares identicos (CPT-IP) se ha utilizado ampliamente para evaluar los deficits de atencion en los trastornos del neurodesarrollo, neurologicos y psiquiatricos. Sin embargo, la localizacion de la activacion cerebral de las redes atencionales varia significativamente segun el diseño de resonancia magnetica funcional (RMf) usado. Objetivo. Diseñar una tarea para evaluar la atencion sostenida y la memoria de trabajo mediante RMf para proporcionar datos de investigacion relacionados con la localizacion y el papel de estas funciones. Sujetos y metodos. El estudio conto con la participacion de 40 estudiantes, todos ellos diestros (50%, mujeres; rango: 18-25 años). La tarea de CPT-IP se diseño como una tarea de bloques, en la que se combinaban los periodos CPT-IP con los de reposo. Resultados. La tarea de CPT-IP utilizada activa una red formada por regiones frontales, parietales y occipitales, y estas se relacionan con funciones ejecutivas y atencionales. Conclusiones. La tarea de CPT-IP utilizada en nuestro trabajo proporciona datos normativos en adultos sanos para el estudio del sustrato neural de la atencion sostenida y la memoria de trabajo. Estos datos podrian ser utiles para evaluar trastornos que cursan con deficits en memoria de trabajo y en atencion sostenida.

  20. [Genetic isolates and inbreeding customs in three rural municipalities from Honduras].

    PubMed

    Herrera-Paz, Edwin Francisco

    2016-01-01

    Introducción: el método de isonimia ha sido utilizado ampliamente para la determinación de la estructura genética aproximada de las poblaciones humanas. El objetivo del estudio fue evaluar la magnitud del aislamiento genético y las costumbres endogámicas en 57 comunidades de tres municipios rurales de Honduras utilizando las técnicas de isonimia. Métodos: se utilizó el listado de 408 apellidos diferentes utilizados por 20 712 votantes registrados en el Tribunal Supremo Electoral, que residen en las 57 comunidades estudiadas. Para cada comunidad se calcularon los valores de la isonimia aleatoria (IR), no aleatoria (IN) y total (IT) con el fin de evaluar los coeficientes de consanguinidad FST, FIS y FIT. Resultados: se encontró alta consanguinidad debido a aislamiento y a costumbres endogámicas en muchas comunidades. En los tres municipios se observó desviación significativa del comportamiento exógamo típico de otras poblaciones de Honduras. Conclusiones: muchas de las comunidades estudiadas presentan una elevada consanguinidad debido al aislamiento, la segregación étnica y/o costumbres endogámicas.

  1. Effects of cumulus cells on rabbit oocyte in vitro maturation.

    PubMed

    Tao, Y; Cao, C; Zhang, M; Fang, F; Liu, Y; Zhang, Y; Ding, J; Zhang, X

    2008-08-01

    Cumulus cells (CCs) are of great importance in oocyte development and maturation in many species, but detailed influence of CCs has not been extensively examined, especially on rabbit. The present study was designed to investigate the effects of CCs and the elongation of in vitro maturation (IVM) time on rabbit oocyte nuclear and ooplasmic maturation and survival. Cumulus oocyte complexes (COCs) and naked oocytes (NOs) were recovered directly from rabbits super-ovulated with eCG. Corona-enclosed oocytes (COs) and denuded oocytes (DOs) were obtained from COCs after removing a part or whole of CCs. The oocytes were cultured in the following seven groups. (i) Cumulus cell enclosed oocytes (CEOs) were cultured alone (CEOs); (ii) COs were cultured alone (COs); (iii) DOs were cultured alone (DOs); (iv) NOs were cultured alone; (v) DOs were co-cultured with COCs [DOs(COCs)]; (vi) DOs were co-cultured with CCs [DOs(CCs)]; (vii) NOs were co-cultured with CCs [NOs(CCs)]. After the oocytes were cultured for 24 and 30 h, the nuclear maturation was evaluated by first polar body (PB1) extrusion while the ooplasmic maturation was evaluated by the cleavage rate after parthenogenetic activation. The results showed that the nuclear maturation rate of CEOs, COs, DOs(COCs) and DOs(CCs) after 24 h incubation were significantly different from each other (p < or = 0.05), the rate of DOs(CCs) was similar to that of DOs (p > or = 0.05). The cleavage rates in the first two groups were significantly higher than those of the others (p < 0.05). For oocytes cultured for 30 h, the nuclear maturation rates were significantly different for each culture model (p < 0.05). The cleavage rates in first two groups were significantly higher than those of others (p < 0.05). Both the nuclear and cleavage rates significantly increased when the culture time of DOs(COCs) was prolonged from 24 to 30 h. DOs(CCs) nuclear maturation was significantly improved when the culture time was prolonged from 24 to 30 h

  2. Phonon density of states of Sn in textured SnO under high pressure: Comparison of nuclear inelastic x-ray scattering spectra to a shell model

    SciTech Connect

    Giefers, H.; Koval, S.; Wortmann, G.; Sturhahn, W.; Alp, E. E.; Hu, M. Y.

    2006-09-01

    The local phonon density of states (DOS) at the Sn site in tin monoxide (SnO) is studied at pressures up to 8 GPa with {sup 119}Sn nuclear resonant inelastic x-ray scattering (NRIXS) of synchrotron radiation at 23.88 keV. The preferred orientation (texture) of the SnO crystallites in the investigated samples is used to measure NRIXS spectra preferentially parallel and almost perpendicular to the c axis of tetragonal SnO. A subtraction method is applied to these NRIXS spectra to produce projected local Sn DOS spectra as seen parallel and perpendicular to the c axis of SnO. These experimentally obtained local Sn DOS spectra, both in the polycrystalline case as well as projected parallel and perpendicular to the c axis, are compared with corresponding theoretical phonon DOS spectra, derived from dispersion relations calculated with a recently developed shell model. Comparison between the experimental projected Sn DOS spectra and the corresponding theoretical DOS spectra enables us to follow the pressure-induced shifts of several acoustic and optic phonon modes. While the principal spectral features of the experimental and theoretical phonon DOS agree well at energies above 10 meV, the pressure behavior of the low-energy part of the DOS is not well reproduced by the theoretical calculations. In fact, they exhibit, in contrast to the experimental data, a dramatic softening of two low-energy modes, their energies approaching zero around 2.5 GPa, clearly indicating the limitations of the applied shell model. These difficulties are obviously connected with the complex Sn-O and Sn-Sn bindings within and between the Sn-O-Sn layers in the litharge structure of SnO. We derived from the experimental and theoretical DOS spectra a variety of elastic and thermodynamic parameters of the Sn sublattice, such as the Lamb-Moessbauer factor, the mean force constant, and Debye temperatures, as well as the vibrational contributions to the Helmholtz free energy, specific heat, entropy, and

  3. Molecular evidence for abiotic sulfurization of dissolved organic matter in marine shallow hydrothermal systems

    NASA Astrophysics Data System (ADS)

    Gomez-Saez, Gonzalo V.; Niggemann, Jutta; Dittmar, Thorsten; Pohlabeln, Anika M.; Lang, Susan Q.; Noowong, Ann; Pichler, Thomas; Wörmer, Lars; Bühring, Solveig I.

    2016-10-01

    Shallow submarine hydrothermal systems are extreme environments with strong redox gradients at the interface of hot, reduced fluids and cold, oxygenated seawater. Hydrothermal fluids are often depleted in sulfate when compared to surrounding seawater and can contain high concentrations of hydrogen sulfide (H2S). It is well known that sulfur in its various oxidation states plays an important role in processing and transformation of organic matter. However, the formation and the reactivity of dissolved organic sulfur (DOS) in the water column at hydrothermal systems are so far not well understood. We investigated DOS dynamics and its relation to the physicochemical environment by studying the molecular composition of dissolved organic matter (DOM) in three contrasting shallow hydrothermal systems off Milos (Eastern Mediterranean), Dominica (Caribbean Sea) and Iceland (North Atlantic). We used ultra-high resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) to characterize the DOM on a molecular level. The molecular information was complemented with general geochemical data, quantitative dissolved organic carbon (DOC) and DOS analyses as well as isotopic measurements (δ2H, δ18O and F14C). In contrast to the predominantly meteoric fluids from Dominica and Iceland, hydrothermal fluids from Milos were mainly fed by recirculating seawater. The hydrothermal fluids from Milos were enriched in H2S and DOS, as indicated by high DOS/DOC ratios and by the fact that >90% of all assigned DOM formulas that were exclusively present in the fluids contained sulfur. In all three systems, DOS from hydrothermal fluids had on average lower O/C ratios (0.26-0.34) than surrounding surface seawater DOS (0.45-0.52), suggesting shallow hydrothermal systems as a source of reduced DOS, which will likely get oxidized upon contact with oxygenated seawater. Evaluation of hypothetical sulfurization reactions suggests DOM reduction and sulfurization during seawater

  4. Structures of the catalytic EAL domain of the Escherichia coli direct oxygen sensor.

    PubMed

    Tarnawski, Miroslaw; Barends, Thomas R M; Hartmann, Elisabeth; Schlichting, Ilme

    2013-06-01

    The direct oxygen sensor DosP is a multidomain protein that contains a gas-sensing haem domain and an EAL effector domain. EAL domains are omnipresent signal transduction domains in bacteria. Many EAL domains are active phosphodiesterases and are involved in breakdown of the ubiquitous bacterial second messenger cyclic di-GMP. Despite a great deal of information on the functional and structural aspects of active and inactive EAL domains, little is known about the structural basis of their regulation by their associated sensory domains. Here, two crystal structures of the Escherichia coli DosP EAL domain derived from cubic and monoclinic crystal forms that were obtained under tartrate and PEG conditions, respectively, are described. Both of the structures display the typical TIM (triosephosphate isomerase) barrel fold with one antiparallel β-strand. However, unlike other EAL structures, access to the active site in DosP EAL is sterically restricted by the presence of a short helical stretch (Ser637-Ala-Leu-His640) in loop L3 between strand β3 and helix α3. This element, together with an unordered fragment, replaces the short α-helix (named α5 in Tbd1265 EAL) that is found in other EAL-domain structures. Since DosP EAL is an active c-di-GMP phosphodiesterase, the observed inactive conformation is suggested to be of functional relevance for the regulation mechanism of DosP.

  5. Oocyte-secreted factors in oocyte maturation media enhance subsequent development of bovine cloned embryos.

    PubMed

    Su, Jianmin; Wang, Yongsheng; Zhang, Lei; Wang, Bo; Liu, Jun; Luo, Yan; Guo, Zekun; Quan, Fusheng; Zhang, Yong

    2014-04-01

    Successful in vitro maturation (IVM) and oocyte quality both affect the subsequent development of cloned embryos derived from somatic-cell nuclear transfer (SCNT). Developmental competence is usually lower in oocytes matured in vitro compared with those that matured in vivo, possibly due to insufficient levels of oocyte-secreted factors (OSFs) and disrupted oocyte-cumulus communication. This study investigated the effects of OSFs secreted by denuded oocytes (DOs) during IVM on the subsequent developmental competence of cloned bovine embryos. Cumulus-oocyte complexes (COCs) from antral follicles of slaughtered-cow ovaries collected from an abattoir were divided into four groups: COCs co-cultured with and without DOs in maturation media used for SCNT, as well as COCs co-cultured with and without DOs in maturation media used for in vitro fertilization (IVF). Based on the developmental competence and embryo quality of bovine embryos generated from these four groups, we found that co-culturing the COCs with DOs enhanced the in vitro development of IVF and cloned bovine embryos, and potentially generated more high-quality cloned blastocysts that possessed locus-specific histone modifications at levels similar to in vitro-fertilized embryos. These results strongly suggest that co-culturing COCs with DOs enhances subsequent developmental competence of cloned bovine embryo.

  6. Superconductivity in Bismuth. A New Look at an Old Problem.

    PubMed

    Mata-Pinzón, Zaahel; Valladares, Ariel A; Valladares, Renela M; Valladares, Alexander

    2016-01-01

    To investigate the relationship between atomic topology, vibrational and electronic properties and superconductivity of bismuth, a 216-atom amorphous structure (a-Bi216) was computer-generated using our undermelt-quench approach. Its pair distribution function compares well with experiment. The calculated electronic and vibrational densities of states (eDOS and vDOS, respectively) show that the amorphous eDOS is about 4 times the crystalline at the Fermi energy, whereas for the vDOS the energy range of the amorphous is roughly the same as the crystalline but the shapes are quite different. A simple BCS estimate of the possible crystalline superconducting transition temperature gives an upper limit of 1.3 mK. The e-ph coupling is more preponderant in a-Bi than in crystalline bismuth (x-Bi) as indicated by the λ obtained via McMillan's formula, λc = 0.24 and experiment λa = 2.46. Therefore with respect to x-Bi, superconductivity in a-Bi is enhanced by the higher values of λ and of eDOS at the Fermi energy.

  7. Low-energy density of states in d-wave superconductors with extended scatterers

    NASA Astrophysics Data System (ADS)

    Adagideli, I.; Sheehy, D. E.; Goldbart, P. M.

    2002-03-01

    We investigate a novel contribution to the low-energy quasiparticle density of states (DOS) of a disordered d-wave superconductor. Related work (C. Pépin and P. A. Lee, Phys. Rev. B 63), 054502 (2001). found that the DOS is singular at zero energy, but it was later argued (A.G. Yashenkin et al., Phys. Rev. Lett. 86), 5982 (2001); A. Altland, cond-mat/0108079 (unpublished). that the results of Ref. [1] are valid only in special cases requiring fine-tuning of the parameters, and that the DOS vanishes at E=0 except in these cases. A common feature of these approaches is the assumption that the disorder potential is due to pointlike scatterers. However, previous work (I. Adagideli et al., Phys. Rev. Lett. 83) 5571 (1999). showed that the presence of extended impurities in d-wave superconductors gives rise to additional low-energy quasiparticle states. Motivated by this fact, we focus on the (previously neglected) contribution to the low-energy DOS arising from a disorder potential that consists of a random collection of extended impurities. We find that the DOS is singular at zero energy, diverging as ρ_ext(E) ~ 1/\\vert E(ln \\vert E\\vert)^3 \\vert. Our calculation neglects the role of nodal quasiparticles; indeed, we expect that they will merely furnish a subdominant additive contribution to ρ_ ext. This work was supported by D.O.E.

  8. Investigation into the Gaussian density of states widths of organic semiconductors

    NASA Astrophysics Data System (ADS)

    Whitcher, T. J.; Wong, W. S.; Talik, A. N.; Woon, K. L.; Chanlek, N.; Nakajima, H.; Saisopa, T.; Songsiriritthigul, P.

    2016-08-01

    The determination of the Gaussian density of states (DOS) width and its influence on charge injection/extraction across an interface are of critical importance for the accurate physical understanding of the optoelectronic properties of organic electronics. A new technique is developed here, whereby the DOS width is extracted by numerical fitting of experimental band-bending observed across an interface. This is done by exploiting the fact that the band-bending can be influenced by the disordered nature of energetic sites that are involved in charge transfer across an interface. This technique is applied on a single component and blended mixture of materials. This approach is successfully tested on poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), poly(N-vinylcarbazole) (PVK), 2,7-bis(diphenylphosphoryl)-9,9‧-spirobifluorene (SPPO13) and poly(3-hexylthiophene-2,5-diyl) (P3HT) in a number of interfaces. The DOS width of PEDOT:PSS, PVK, SPPO13 and P3HT were calculated to be 105 meV, 144 meV, 178 meV and 80 meV respectively. The impact of DOS width on the interface between two materials is investigated. The Fermi level pinning model used to describe the hole barrier between an inorganic electrode and an organic semiconductor fails when applied to the interface between two organic semiconductors. Their energetic barriers are very highly dependent on the DOS of the materials.

  9. Influence of co-culture with denuded oocytes during in vitro maturation on fertilization and developmental competence of cumulus-enclosed porcine oocytes in a defined system.

    PubMed

    Appeltant, Ruth; Somfai, Tamás; Kikuchi, Kazuhiro; Maes, Dominiek; Van Soom, Ann

    2016-04-01

    Co-culture of cumulus-oocyte complexes (COCs) with denuded oocytes (DOs) during in vitro maturation (IVM) was reported to improve the developmental competence of oocytes via oocyte-secreted factors in cattle. The aim of the present study was to investigate if addition of DOs during IVM can improve in vitro fertilization (IVF) and in vitro culture (IVC) results for oocytes in a defined in vitro production system in pigs. The maturation medium was porcine oocyte medium supplemented with gonadotropins, dbcAMP and β-mercaptoethanol. Cumulus-oocyte complexes were matured without DOs or with DOs in different ratios (9 COC, 9 COC+16 DO and 9 COC+36 DO). Consequently; oocytes were subjected to IVF as intact COCs or after denudation to examine if DO addition during IVM would affect cumulus or oocyte properties. After fertilization, penetration and normal fertilization rates of zygotes were not different between all tested groups irrespective of denudation before IVF. When zygotes were cultured for 6 days, no difference could be observed between all treatment groups in cleavage rate, blastocyst rate and cell number per blastocyst. In conclusion, irrespective of the ratio, co-culture with DOs during IVM did not improve fertilization parameters and embryo development of cumulus-enclosed porcine oocytes in a defined system.

  10. Superconductivity in Bismuth. A New Look at an Old Problem.

    PubMed

    Mata-Pinzón, Zaahel; Valladares, Ariel A; Valladares, Renela M; Valladares, Alexander

    2016-01-01

    To investigate the relationship between atomic topology, vibrational and electronic properties and superconductivity of bismuth, a 216-atom amorphous structure (a-Bi216) was computer-generated using our undermelt-quench approach. Its pair distribution function compares well with experiment. The calculated electronic and vibrational densities of states (eDOS and vDOS, respectively) show that the amorphous eDOS is about 4 times the crystalline at the Fermi energy, whereas for the vDOS the energy range of the amorphous is roughly the same as the crystalline but the shapes are quite different. A simple BCS estimate of the possible crystalline superconducting transition temperature gives an upper limit of 1.3 mK. The e-ph coupling is more preponderant in a-Bi than in crystalline bismuth (x-Bi) as indicated by the λ obtained via McMillan's formula, λc = 0.24 and experiment λa = 2.46. Therefore with respect to x-Bi, superconductivity in a-Bi is enhanced by the higher values of λ and of eDOS at the Fermi energy. PMID:26815431

  11. The impact of interhospital transfers on surgical quality metrics for academic medical centers.

    PubMed

    Crippen, Cristina J; Hughes, Steven J; Chen, Sugong; Behrns, Kevin E

    2014-07-01

    The emergence of pay-for-performance systems pose a risk to an academic medical center's (AMC) mission to provide care for interhospital surgical transfer patients. This study examines quality metrics and resource consumption for a sample of these patients from the University Health System Consortium (UHC) and our Department of Surgery (DOS). Standard benchmarks, including mortality rate, length of stay (LOS), and cost, were used to evaluate the impact of interhospital surgical transfers versus direct admission (DA) patients from January 2010 to December 2012. For 1,423,893 patients, the case mix index for transfer patients was 38 per cent (UHC) and 21 per cent (DOS) greater than DA patients. Mortality rates were 5.70 per cent (UHC) and 6.93 per cent (DOS) in transferred patients compared with 1.79 per cent (UHC) and 2.93 per cent (DOS) for DA patients. Mean LOS for DA patients was 4 days shorter. Mean total costs for transferred patients were greater $13,613 (UHC) and $13,356 (DOS). Transfer patients have poorer outcomes and consume more resources than DA patients. Early recognition and transfer of complex surgical patients may improve patient rescue and decrease resource consumption. Surgeons at AMCs and in the community should develop collaborative programs that permit collective assessment and decision-making for complicated surgical patients.

  12. The impact of interhospital transfers on surgical quality metrics for academic medical centers.

    PubMed

    Crippen, Cristina J; Hughes, Steven J; Chen, Sugong; Behrns, Kevin E

    2014-07-01

    The emergence of pay-for-performance systems pose a risk to an academic medical center's (AMC) mission to provide care for interhospital surgical transfer patients. This study examines quality metrics and resource consumption for a sample of these patients from the University Health System Consortium (UHC) and our Department of Surgery (DOS). Standard benchmarks, including mortality rate, length of stay (LOS), and cost, were used to evaluate the impact of interhospital surgical transfers versus direct admission (DA) patients from January 2010 to December 2012. For 1,423,893 patients, the case mix index for transfer patients was 38 per cent (UHC) and 21 per cent (DOS) greater than DA patients. Mortality rates were 5.70 per cent (UHC) and 6.93 per cent (DOS) in transferred patients compared with 1.79 per cent (UHC) and 2.93 per cent (DOS) for DA patients. Mean LOS for DA patients was 4 days shorter. Mean total costs for transferred patients were greater $13,613 (UHC) and $13,356 (DOS). Transfer patients have poorer outcomes and consume more resources than DA patients. Early recognition and transfer of complex surgical patients may improve patient rescue and decrease resource consumption. Surgeons at AMCs and in the community should develop collaborative programs that permit collective assessment and decision-making for complicated surgical patients. PMID:24987902

  13. Psychiatry training towards a global future: trainees' perspective in Portugal.

    PubMed

    Pinto da Costa, Mariana; Guerra, Cátia; Malta, Rui; Moura, Manuela; Carvalho, Serafim; Mendonça, Denisa

    2013-01-01

    Introdução: A psiquiatria é influenciada pelas mudanças que ocorrem na sociedade, devendo estar em constante renovação, antevendo futuros comportamentos e doenças. Este estudo pretende descrever a opinião dos internos de psiquiatria em Portugal relativamente ao seu internato e às modificações que nele gostariam de assistir no futuro próximo.Material e Métodos: Um questionário estruturado de 26 perguntas foi desenvolvido pela Associação Portuguesa de Internos de Psiquiatria e enviado por email.Resultados: A percentagem de respostas obtidas foi de 41,5%. A maioria dos internos estava satisfeita com a sua formação. Contudo, algumas mudanças foram sugeridas no que diz respeitos aos estágios obrigatórios e opcionais. A maior parte dos internos requer que as psicoterapias sejam incluídas no âmbito do internato, solicitando também um acesso mais fácil à investigação e a oportunidades de estágio no estrangeiro.Discussão e Conclusão: Esta perspectiva detalhada pode facilitar a transformação dos currículos do internato em Portugal e naEuropa, permitindo a melhoria do internato de psiquiatria, bem como dos cuidados de saúde mental.

  14. Superconductivity in Bismuth. A New Look at an Old Problem

    PubMed Central

    2016-01-01

    To investigate the relationship between atomic topology, vibrational and electronic properties and superconductivity of bismuth, a 216-atom amorphous structure (a-Bi216) was computer-generated using our undermelt-quench approach. Its pair distribution function compares well with experiment. The calculated electronic and vibrational densities of states (eDOS and vDOS, respectively) show that the amorphous eDOS is about 4 times the crystalline at the Fermi energy, whereas for the vDOS the energy range of the amorphous is roughly the same as the crystalline but the shapes are quite different. A simple BCS estimate of the possible crystalline superconducting transition temperature gives an upper limit of 1.3 mK. The e-ph coupling is more preponderant in a-Bi than in crystalline bismuth (x-Bi) as indicated by the λ obtained via McMillan’s formula, λc = 0.24 and experiment λa = 2.46. Therefore with respect to x-Bi, superconductivity in a-Bi is enhanced by the higher values of λ and of eDOS at the Fermi energy. PMID:26815431

  15. Influence of annealing atmospheres and synthetic air treatment on solution processed zinc oxide thin film transistors

    NASA Astrophysics Data System (ADS)

    Busch, C.; Schierning, G.; Theissmann, R.; Schmechel, R.

    2012-08-01

    Thin film transistors (TFTs) based on active layers of zinc oxide prepared from a solution process were fabricated under different annealing conditions. The influence of the annealing gas as well as the influence of a subsequent exposure to synthetic air to the device properties is considered. Annealing under N2 or H2 atmosphere leads to a strong negative threshold voltage shift. With respect to known defect states in ZnO, two different donor states are suggested to be responsible for the negative threshold voltage. A subsequent synthetic air treatment causes in general a positive threshold voltage shift. However, transistors annealed under H2 degrade very fast under synthetic air in contrast to transistors annealed under N2. In order to obtain more information about the density of states (DOS) distribution, a transistor model for thin film transistors in the hopping transport regime (Vissenberg model) was utilized. For positive threshold voltages, the DOS distribution is independent from the gas treatment and the threshold voltage within the experimental accuracy. This indicates a shift of the Fermi-level within an exponentially decaying DOS. The change in the charge carrier density is either due to shallow donors or due to a charge transfer with acceptors at the surface. In contrast, for negative threshold voltages, the DOS distribution parameter rises, indicating a flatter DOS distribution. We suggest that the difference is due to the change from accumulation mode to the depletion mode of the device.

  16. Trap density of states in n-channel organic transistors: variable temperature characteristics and band transport

    SciTech Connect

    Cho, Joung-min Akiyama, Yuto; Kakinuma, Tomoyuki; Mori, Takehiko

    2013-10-15

    We have investigated trap density of states (trap DOS) in n-channel organic field-effect transistors based on N,N ’-bis(cyclohexyl)naphthalene diimide (Cy-NDI) and dimethyldicyanoquinonediimine (DMDCNQI). A new method is proposed to extract trap DOS from the Arrhenius plot of the temperature-dependent transconductance. Double exponential trap DOS are observed, in which Cy-NDI has considerable deep states, by contrast, DMDCNQI has substantial tail states. In addition, numerical simulation of the transistor characteristics has been conducted by assuming an exponential trap distribution and the interface approximation. Temperature dependence of transfer characteristics are well reproduced only using several parameters, and the trap DOS obtained from the simulated characteristics are in good agreement with the assumed trap DOS, indicating that our analysis is self-consistent. Although the experimentally obtained Meyer-Neldel temperature is related to the trap distribution width, the simulation satisfies the Meyer-Neldel rule only very phenomenologically. The simulation also reveals that the subthreshold swing is not always a good indicator of the total trap amount, because it also largely depends on the trap distribution width. Finally, band transport is explored from the simulation having a small number of traps. A crossing point of the transfer curves and negative activation energy above a certain gate voltage are observed in the simulated characteristics, where the critical V{sub G} above which band transport is realized is determined by the sum of the trapped and free charge states below the conduction band edge.

  17. Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma

    NASA Astrophysics Data System (ADS)

    Rohrbach, Daniel J.; Rigual, Nestor; Arshad, Hassan; Tracy, Erin C.; Cooper, Michelle T.; Shafirstein, Gal; Wilding, Gregory; Merzianu, Mihai; Baumann, Heinz; Henderson, Barbara W.; Sunar, Ulas

    2016-01-01

    This study investigated whether diffuse optical spectroscopy (DOS) measurements could assess clinical response to photodynamic therapy (PDT) in patients with head and neck squamous cell carcinoma (HNSCC). In addition, the correlation between parameters measured with DOS and the crosslinking of signal transducer and activator of transcription 3 (STAT3), a molecular marker for PDT-induced photoreaction, was investigated. Thirteen patients with early stage HNSCC received the photosensitizer 2-[1-hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH) and DOS measurements were performed before and after PDT in the operating room (OR). In addition, biopsies were acquired after PDT to assess the STAT3 crosslinking. Parameters measured with DOS, including blood volume fraction, blood oxygen saturation (StO2), HPPH concentration (cHPPH), HPPH fluorescence, and blood flow index (BFI), were compared to the pathologic response and the STAT3 crosslinking. The best individual predictor of pathological response was a change in cHPPH (sensitivity=60%, specificity=100%), while discrimination analysis using a two-parameter classifier (change in cHPPH and change in StO2) classified pathological response with 100% sensitivity and 100% specificity. BFI showed the best correlation with the crosslinking of STAT3. These results indicate that DOS-derived parameters can assess the clinical response in the OR, allowing for earlier reintervention if needed.

  18. Carbon Nanotubes with Tailored Density of Electronic States for Electrochemical Applications.

    PubMed

    Song, Yingpan; Hu, Huifang; Feng, Miao; Zhan, Hongbing

    2015-11-25

    The density of electronic states (DOS) is an intrinsic electronic property that works conclusively in the electrochemistry of carbon materials. However, seldom has it been reported how the DOS at the Fermi level influences the electrochemical activity. In this work, we synthesized partially and fully unzipped carbon nanotubes by longitudinally unzipping pristine carbon nanotubes (CNTs). We then studied the electrochemical activity and biosensitivity of carbon materials by means of the CNTs and their derivatives to elucidate the effect of the DOS on their electrochemical performances. Tailoring of the DOS for the CNT derivatives could be conveniently realized by varying the sp(2)/sp(3) ratio (i.e., graphite concentration) through manipulating the oxidative unzipping degree. Despite the diverse electron transfer mechanisms and influence factors of the four investigated redox probes (IrCl6(2-), [Fe(CN)6](3-), Fe(3+), and ascorbic acid), the CNT derivatives exhibited consistent kinetic behaviors, wherein CNTs with a high DOS showed superior electrochemical response compared with partially and fully unzipped carbon nanotubes. For biological detection, the CNTs could simultaneously distinguish ascorbic acid, dopamine, and uric acid, while the three CNT derivatives could all differentiate phenethylamine and epinephrine existed in the newborn calf serum. Moreover, the three CNT derivatives all presented wide linear detection ranges with high sensitivities for dopamine, phenethylamine, and epinephrine.

  19. Death obsession in Palestinians.

    PubMed

    Abdel-Khalek, Ahmed M; Al-Arja, Nahida S; Abdalla, Taysir

    2006-04-01

    The authors explored death obsession level and correlates among a sample (N = 601) of Palestinians living in the city of Beit Jala, the village of Al-Khader, and the Aida refugee camp in the Bethlehem area. They live in war conditions; the houses of half of them have been demolished. The Death Obsession Scale (DOS) was administered. Its alpha reliability was .92, denoting high internal consistency. Among women, it yielded 1 factor, (General Death Obsession), whereas among men it yielded 3 factors: Death Rumination, Death Dominance, and Death Idea Repetition. Palestinian men and women attained significantly lower DOS mean scores than participants from 4 Arab countries: Egypt, Kuwait, Syria, and Lebanon in 7 out of 8 comparisons. However, Palestinian women had significantly higher DOS mean score than their Spanish, American and British counterparts, whereas Palestinian men had significantly higher mean DOS score than Spanish peers. The low DOS scores of Palestinians, in proportion to other Arab samples, may reflect their adaptation to strife and violence.

  20. In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy

    NASA Astrophysics Data System (ADS)

    Chung, S. H.; Cerussi, A. E.; Klifa, C.; Baek, H. M.; Birgul, O.; Gulsen, G.; Merritt, S. I.; Hsiang, D.; Tromberg, B. J.

    2008-12-01

    Structural changes in water molecules are related to physiological, anatomical and pathological properties of tissues. Near infrared (NIR) optical absorption methods are sensitive to water; however, detailed characterization of water in thick tissues is difficult to achieve because subtle spectral shifts can be obscured by multiple light scattering. In the NIR, a water absorption peak is observed around 975 nm. The precise NIR peak's shape and position are highly sensitive to water molecular disposition. We introduce a bound water index (BWI) that quantifies shifts observed in tissue water absorption spectra measured by broadband diffuse optical spectroscopy (DOS). DOS quantitatively measures light absorption and scattering spectra and therefore reveals bound water spectral shifts. BWI as a water state index was validated by comparing broadband DOS to magnetic resonance spectroscopy, diffusion-weighted MRI and conductivity in bound water tissue phantoms. Non-invasive DOS measurements of malignant and normal breast tissues performed in 18 subjects showed a significantly higher fraction of free water in malignant tissues (p < 0.0001) compared to normal tissues. BWI of breast cancer tissues inversely correlated with Nottingham-Bloom-Richardson histopathology scores. These results highlight broadband DOS sensitivity to molecular disposition of water and demonstrate the potential of BWI as a non-invasive in vivo index that correlates with tissue pathology.

  1. Study of the electronic and magnetic properties of EuAlO{sub 3} using FP-LAPW method

    SciTech Connect

    Sandeep, Shankar, A.; Rai, D. P.; Thapa, R. K.; Ghimire, M. P.

    2015-05-15

    The electronic and magnetic properties of EuAlO{sub 3} is calculated by first-principles full-potential linearized augmented plane wave (FP-LAPW) method based on density functional theory (DFT). Density of states (DOS), magnetic moments and band structures of the systems are presented. For the exchange and correlation energy, local spin density approximation (LSDA+U) with the inclusion of Hubbard potential U is used. Our calculation showed an indirect band gap of the order of 4 eV for EuAlO{sub 3} in the spin down channel of the DOS and band structures supporting HMF nature of the system. The effective magnetic moment of 6.00 µ{sub B} also supported the above conclusion with an integral value. The DOS of Eu were found responsible for the HMF nature of the system.

  2. Buracos negros primordiais e astrofísica observacional

    NASA Astrophysics Data System (ADS)

    Custódio, P. S.; Horvath, J. E.

    2003-02-01

    A história da física contemporânea é pródiga em grandes descobertas (a Relatividade e a Mecânica Quântica entre as mais importantes) até meados dos anos '30. O peso destes desenvolvimentos é tão grande que outros feitos de grande porte (por exemplo, a teoria da nucleossíntese nas estrelas) são geralmente considerados como "filhotes" dos primeiros, ao menos na imaginação popular. Porém, algumas exceções à regra não-escrita são dignas de menção. Entre estas últimas está a descoberta por S.W.Hawking e colaboradores das propriedades de emissão dos buracos negros, trabalho que iniciou uma disciplina com vida própria denominada Termodinâmica de Buracos Negros.

  3. Resonance frequency shifts due to quantized electronic states in atomically thin NEMS

    NASA Astrophysics Data System (ADS)

    Chen, Changyao; Deshpande, Vikram; Koshino, Mikito; Lee, Sunwoo; Gondarenko, Alexander; MacDonald, Allan; Kim, Philip; Hone, James

    The classic picture of the force exerted on a parallel plate capacitor assumes infinite density of states (DOS), which implies identical electrochemical and electrostatic potential. However, such assumption can breakdown in low-dimensional devices where the DOS is finite or quantized. Here we consider the mechanical resonance shift of a nanoelectromechanical (NEMS) resonator with small DOS, actuated and detected capacitively at fixed electrochemical potential. We found three leading correction terms to the classical picture: the first term leads to the modulation of static force due to the variation in chemical potential, and the second and third terms are related to the static and dynamic changes in spring constants, caused by quantum capacitance. The theory agrees well with recent experimental findings from graphene resonator in quantum Hall regimes, where the chemical potential and quantum capacitance are tuned by magnetic field, while the gate voltage is kept constant.

  4. Insights into redox sensing metalloproteins in Mycobacterium tuberculosis.

    PubMed

    Chim, Nicholas; Johnson, Parker M; Goulding, Celia W

    2014-04-01

    Mycobacterium tuberculosis, the pathogen that causes tuberculosis, has evolved sophisticated mechanisms for evading assault by the human host. This review focuses on M. tuberculosis regulatory metalloproteins that are sensitive to exogenous stresses attributed to changes in the levels of gaseous molecules (i.e., molecular oxygen, carbon monoxide and nitric oxide) to elicit an intracellular response. In particular, we highlight recent developments on the subfamily of Whi proteins, redox sensing WhiB-like proteins that contain iron-sulfur clusters, sigma factors and their cognate anti-sigma factors of which some are zinc-regulated, and the dormancy survival regulon DosS/DosT-DosR heme sensory system. Mounting experimental evidence suggests that these systems contribute to a highly complex and interrelated regulatory network that controls M. tuberculosis biology. This review concludes with a discussion of strategies that M. tuberculosis has developed to maintain redox homeostasis, including mechanisms to regulate endogenous nitric oxide and carbon monoxide levels.

  5. NDE evaluation of the intergranular corrosion susceptibility of a 2205 duplex stainless steel using thermoelectric power and double loop electrochemical potentiokinetic reactivation methods

    NASA Astrophysics Data System (ADS)

    Ortiz, N.; Carreón, H.; Ruiz, A.

    2013-01-01

    There is a need for a nondestructive technique to assess rapidly and with confidence the degree of sensitization (DOS) in duplex stainless steel (DSS). In this investigation, we present the use of thermoelectric power (TEP) measurements as nondestructive method for the determination of DOS in isothermally aged 2205 DSS at 700°C for different aging times. The DOS of the aged samples was first established by performing the double loop electrochemical potentiokinetic reactivation (DL-EPR) test. The microstructural evolution was evaluated by scanning electron microscopy (SEM). Experimental results indicate that TEP coefficient is sensitive to gradual microstructural changes produced by thermal aging and can be used to monitor IGC sensitization of 2205 duplex stainless steel.

  6. Strong odd-frequency correlations in fully gapped Zeeman-split superconductors.

    PubMed

    Linder, Jacob; Robinson, Jason W A

    2015-01-01

    It is now well established that at a superconductor/ferromagnet (S/F) interface an unconventional superconducting state arises in which the pairing is odd-frequency. The hallmark signature of this superconducting state is generally understood to be an enhancement of the electronic density of states (DoS) at subgap energies close to the S/F interface. However, here we show that an odd frequency state can be present even if the DoS is fully gapped. As an example, we show that this is the case in the pioneering S/FI (where FI is a insulating ferromagnet) tunneling experiments of Meservey and Tedrow, and we derive a generalized analytical criterium to describe the effect of odd-frequency pairing on the DoS. Finally, we propose a simple experiment in which odd-frequency pairing in a Zeeman-split superconductor can be unambiguously detected via the application of an external magnetic field. PMID:26503380

  7. Unconventional temperature dependence of the cuprate excitation spectrum

    NASA Astrophysics Data System (ADS)

    Sacks, William; Mauger, Alain; Noat, Yves

    2016-08-01

    Key properties of the cuprates, such as the pseudogap observed above the critical temperature Tc, remain highly debated. Given their importance, we recently proposed a novel mechanism based on the Bose-like condensation of mutually interacting Cooper pairs [W. Sacks, A. Mauger, Y. Noat, Supercond. Sci. Technol. 28, 105014 (2015)]. In this work, we calculate the temperature dependent DOS using this model for different doping levels from underdoped to overdoped. In all situations, due to the presence of excited pairs, a pseudogap is found above Tc while the normal DOS is recovered at T∗, the pair formation temperature. A similar behavior is found as a function of magnetic field, crossing a vortex, where a pseudogap exists in the vortex core. We show that the precise DOS shape depends on combined pair (boson) and quasiparticle (fermion) excitations, allowing for a deeper understanding of the SC to the PG transition.

  8. Rheological and Magnetorheological Behaviour of Some Magnetic Fluids on Polar and Nonpolar Carrier Liquids

    NASA Astrophysics Data System (ADS)

    Bălău, Oana; Bica, Doina; Koneracka, Martina; Kopčansky, Peter; Susan-Resiga, Daniela; Vékás, Ladislau

    Rheological and magnetorheological behaviour of monolayer and double layer sterically stabilized magnetic fluids, with transformer oil (UTR), diloctilsebacate (DOS), heptanol (Hept), pentanol (Pent) and water (W) as carrier liquids, were investigated. The data for volumic concentration dependence of dynamic viscosity of high colloidal stability UTR, DOS, Hept and Pent samples are particularly well fitted by the formulas given by Vand (1948) and Chow (1994). The Chow type dependence proved its universal character as the viscosity data for dilution series of various magnetic fluids are well fitted by the same curve, regardless the nonpolar or polar charcater of the sample. The magnetorheological effect measured for low and medium concentration water based magnetic fluids is much higher, due to agglomerate formation process, than the corresponding values obtained for the well stabilized UTR, DOS, Hept and Pent samples, even at very high volumic fraction of magnetic nanoparticles.

  9. Significance of decay mechanism into continuum in dynamical Wannier-Stark ladder

    SciTech Connect

    Nemoto, Yuya; Maeshima, Nobuya; Hino, Ken-ichi

    2013-12-04

    We examine the resonance structure of photodressed electron states of laser-driven Wannier-Stark ladder, namely, dynamic Wannier-Stark ladder, in terms of the excess density of states (DOS) closely related to a lifetime of the state of concern. It is revealed that the resonance structure in the strong laser-field region shows clear dependence on the ratio, η, of a Bloch-frequency to a laser frequency. As the laser strength increases, for η = 1, the excess DOS becomes involved with a lot of newly-growing resonance peaks. This result would be understood from the viewpoint of a Fano-like decay-mechanism caused by a multichannel continuum effect, in marked contrast to the cases of larger η’s; for η = 3, the excess DOS just is found to show a pronounced red-shift of a single dominant peak caused by a single-channel continuum effect.

  10. Extraction of high charge density of states in electrolyte-gated polymer thin-film transistor with temperature-dependent measurements

    NASA Astrophysics Data System (ADS)

    Lee, Jiyoul

    2016-05-01

    Using temperature-dependent charge transport measurements, we investigated spectral density of states (DOS) in the bandgap of polythiophene thin-films under high carrier densities (<3.5 × 1020 cm-3) induced by electrochemical doping. The thermally activated charge transport indicates that the electrical currents in the polymer thin-film under high charge density state follow the Meyer-Neldel rule. The spectral DOS extracted from the electrolyte-gated polymer film lie in the range of 8.0 × 1019 cm-3 eV-1-8.0 × 1021 cm-3 eV-1, which are at least two orders of magnitude larger than the DOS extracted from the same polymer film at relatively low induced carrier densities by general oxide dielectrics.

  11. Subgap states in p-channel tin monoxide thin-film transistors from temperature-dependent field-effect characteristics

    NASA Astrophysics Data System (ADS)

    Jeong, Chan-Yong; Lee, Daeun; Han, Young-Joon; Choi, Yong-Jin; Kwon, Hyuck-In

    2015-08-01

    This paper experimentally investigates the subgap density of states (DOS) in p-type tin monoxide (SnO) thin-film transistors (TFTs) for the first time by using temperature-dependent field-effect measurements. As the temperature increases, the turn-on voltage moves in the positive direction, and the off-current and subthreshold slope continuously increase. We found that the conductivity of the SnO TFT obeys the Meyer-Neldel (MN) rule with a characteristic MN parameter of 28.6 eV-1 in the subthreshold region, from which we successfully extracted the subgap DOS by combing the field-effect method and the MN relation. The extracted subgap DOS from fabricated p-type SnO TFTs are exponentially distributed in energy, and exhibit around two orders of magnitude higher values compared to those of the n-type amorphous indium-gallium-zinc oxide TFTs.

  12. Direct determination of defect density of states in organic bulk heterojunction solar cells

    NASA Astrophysics Data System (ADS)

    Verma, Upkar K.; Tripathi, Durgesh C.; Mohapatra, Y. N.

    2016-09-01

    The measurement of the occupied trap density of states (DOS) is important for optimization of organic bulk heterojunction solar cells. We demonstrate a direct method for obtaining it from the trap related peak in capacitance-voltage characteristics under different levels of illumination, and its correlation with the dark current density-voltage characteristics. We use the method to measure the parameters of DOS, occupied trap distribution, and its temperature dependence for poly(3-hexathiophene) (P3HT):phenyl-C61-butyric acid methyl ester (PCBM) based solar cells. The total occupied trap concentration is approximately 7 × 1015 cm-3 with a standard deviation for a truncated Gaussian distribution varying between 32 and 44 meV in the temperature range of 310-270 K within a total Gaussian DOS with a standard deviation of 92 meV.

  13. Strong odd-frequency correlations in fully gapped Zeeman-split superconductors

    PubMed Central

    Linder, Jacob; Robinson, Jason W. A.

    2015-01-01

    It is now well established that at a superconductor/ferromagnet (S/F) interface an unconventional superconducting state arises in which the pairing is odd-frequency. The hallmark signature of this superconducting state is generally understood to be an enhancement of the electronic density of states (DoS) at subgap energies close to the S/F interface. However, here we show that an odd frequency state can be present even if the DoS is fully gapped. As an example, we show that this is the case in the pioneering S/FI (where FI is a insulating ferromagnet) tunneling experiments of Meservey and Tedrow, and we derive a generalized analytical criterium to describe the effect of odd-frequency pairing on the DoS. Finally, we propose a simple experiment in which odd-frequency pairing in a Zeeman-split superconductor can be unambiguously detected via the application of an external magnetic field. PMID:26503380

  14. Phonon anharmonicity of monoclinic zirconia and yttrium-stabilized zirconia

    SciTech Connect

    Li, Chen W.; Smith, Hillary L.; Lan, Tian; Niedziela, Jennifer L.; Munoz, Jorge A.; Keith, J. Brian; Mauger, L.; Abernathy, Douglas L; Fultz, B.

    2015-04-13

    Inelastic neutron scattering measurements on monoclinic zirconia (ZrO2) and 8 mol% yttrium-stabilized zirconia were performed at temperatures from 300 to 1373 ωK. We reported temperature-dependent phonon densities of states (DOS) and Raman spectra obtained at elevated temperatures. First-principles lattice dynamics calculations with density functional theory gave total and partial phonon DOS curves and mode Grüneisen parameters. These mode Grüneisen parameters were used to predict the experimental temperature dependence of the phonon DOS with partial success. However, substantial anharmonicity was found at elevated temperatures, especially for phonon modes dominated by the motions of oxygen atoms. Yttrium-stabilized zirconia (YSZ) was somewhat more anharmonic and had a broader phonon spectrum at low temperatures, owing in part to defects in its structure. YSZ also has a larger vibrational entropy than monoclinic zirconia.

  15. Phonon anharmonicity of monoclinic zirconia and yttrium-stabilized zirconia

    DOE PAGES

    Li, Chen W.; Smith, Hillary L.; Lan, Tian; Niedziela, Jennifer L.; Munoz, Jorge A.; Keith, J. Brian; Mauger, L.; Abernathy, Douglas L; Fultz, B.

    2015-04-13

    Inelastic neutron scattering measurements on monoclinic zirconia (ZrO2) and 8 mol% yttrium-stabilized zirconia were performed at temperatures from 300 to 1373 ωK. We reported temperature-dependent phonon densities of states (DOS) and Raman spectra obtained at elevated temperatures. First-principles lattice dynamics calculations with density functional theory gave total and partial phonon DOS curves and mode Grüneisen parameters. These mode Grüneisen parameters were used to predict the experimental temperature dependence of the phonon DOS with partial success. However, substantial anharmonicity was found at elevated temperatures, especially for phonon modes dominated by the motions of oxygen atoms. Yttrium-stabilized zirconia (YSZ) was somewhat moremore » anharmonic and had a broader phonon spectrum at low temperatures, owing in part to defects in its structure. YSZ also has a larger vibrational entropy than monoclinic zirconia.« less

  16. Tunneling study of cavity grade Nb : possible magnetic scattering at the surface.

    SciTech Connect

    Prolier, T.; Zasadzinski, J. F.; Cooley, L.; Antoine, C.; Moore, J.; Pellin, M.; Norem, J.; Gray, K. E.; Materials Science Division; Illinois Inst. Tech.; FNAL; Centre d'etude de Saclay

    2008-01-01

    Tunneling spectroscopy was performed on Nb pieces prepared by the same processes used to etch and clean superconducting radio frequency (SRF) cavities. Air exposed, electropolished Nb exhibited a surface superconducting gap {Delta} = 1.55 meV, which is characteristic of a clean, bulk Nb. However, the tunneling density of states (DOS) was significantly broadened. The Nb pieces, which were treated with the same mild baking used to improve the Q slope in SRF cavities, reveal a sharper DOS. Good fits to the DOS were obtained by using the Shiba theory, suggesting that magnetic scattering of quasiparticles is the origin of the gapless surface superconductivity and a heretofore unrecognized contributor to the Q-slope problem of Nb SRF cavities.

  17. Phonon anharmonicity of monoclinic zirconia and yttrium-stabilized zirconia

    NASA Astrophysics Data System (ADS)

    Li, C. W.; Smith, H. L.; Lan, T.; Niedziela, J. L.; Muñoz, J. A.; Keith, J. B.; Mauger, L.; Abernathy, D. L.; Fultz, B.

    2015-04-01

    Inelastic neutron scattering measurements on monoclinic zirconia (ZrO2 ) and 8 mol% yttrium-stabilized zirconia were performed at temperatures from 300 to 1373 w K . Temperature-dependent phonon densities of states (DOS) are reported, as are Raman spectra obtained at elevated temperatures. First-principles lattice dynamics calculations with density functional theory gave total and partial phonon DOS curves and mode Grüneisen parameters. These mode Grüneisen parameters were used to predict the experimental temperature dependence of the phonon DOS with partial success. However, substantial anharmonicity was found at elevated temperatures, especially for phonon modes dominated by the motions of oxygen atoms. Yttrium-stabilized zirconia (YSZ) was somewhat more anharmonic and had a broader phonon spectrum at low temperatures, owing in part to defects in its structure. YSZ also has a larger vibrational entropy than monoclinic zirconia.

  18. Effect of substitutional defects on Kambersky damping in L1{sub 0} magnetic materials

    SciTech Connect

    Qu, T.; Victora, R. H.

    2015-02-16

    Kambersky damping, representing the loss of magnetic energy from the electrons to the lattice through the spin orbit interaction, is calculated for L1{sub 0} FePt, FePd, CoPt, and CoPd alloys versus chemical degree of order. When more substitutional defects exist in the alloys, damping is predicted to increase due to the increase of the spin-flip channels allowed by the broken symmetry. It is demonstrated that this corresponds to an enhanced density of states (DOS) at the Fermi level, owing to the rounding of the DOS with loss of long-range order. Both the damping and the DOS of the Co-based alloy are found to be less affected by the disorder. Pd-based alloys are predicted to have lower damping than Pt-based alloys, making them more suitable for high density spintronic applications.

  19. Spin polarization ratios of resistivity and density of states estimated from anisotropic magnetoresistance ratio for nearly half-metallic ferromagnets

    NASA Astrophysics Data System (ADS)

    Kokado, Satoshi; Sakuraba, Yuya; Tsunoda, Masakiyo

    2016-10-01

    We derive a simple relational expression between the spin polarization ratio of resistivity, $P_\\rho$, and the anisotropic magnetoresistance ratio $\\Delta \\rho/\\rho$, and that between the spin polarization ratio of the density of states at the Fermi energy, $P_{\\rm DOS}$, and $\\Delta \\rho/\\rho$ for nearly half-metallic ferromagnets. We find that $P_\\rho$ and $P_{\\rm DOS}$ increase with increasing $|\\Delta \\rho/\\rho|$ from 0 to a maximum value. In addition, we roughly estimate $P_\\rho$ and $P_{\\rm DOS}$ for a Co$_2$FeGa$_{0.5}$Ge$_{0.5}$ Heusler alloy by substituting its experimentally observed $\\Delta \\rho/\\rho$ into the respective expressions.

  20. Tunneling density of states as a function of thickness in superconductor/ strong ferromagnet bilayers

    SciTech Connect

    Reymond, S.

    2010-04-29

    We have made an experimental study of the tunneling density of states (DOS) in strong ferromagnetic thin films (CoFe) in proximity with a thick superconducting film (Nb) as a function of d{sub F}, the ferromagnetic thickness. Remarkably, we find that as d{sub F} increases, the superconducting DOS exhibits a scaling behavior in which the deviations from the normal-state conductance have a universal shape that decreases exponentially in amplitude with characteristic length d* {approx} 0.4 nm. We do not see oscillations in the DOS as a function of d{sub F}, as expected from predictions based on the Usadel equations, although an oscillation in T{sub c}(d{sub F}) has been seen in the same materials.

  1. Strong odd-frequency correlations in fully gapped Zeeman-split superconductors.

    PubMed

    Linder, Jacob; Robinson, Jason W A

    2015-10-27

    It is now well established that at a superconductor/ferromagnet (S/F) interface an unconventional superconducting state arises in which the pairing is odd-frequency. The hallmark signature of this superconducting state is generally understood to be an enhancement of the electronic density of states (DoS) at subgap energies close to the S/F interface. However, here we show that an odd frequency state can be present even if the DoS is fully gapped. As an example, we show that this is the case in the pioneering S/FI (where FI is a insulating ferromagnet) tunneling experiments of Meservey and Tedrow, and we derive a generalized analytical criterium to describe the effect of odd-frequency pairing on the DoS. Finally, we propose a simple experiment in which odd-frequency pairing in a Zeeman-split superconductor can be unambiguously detected via the application of an external magnetic field.

  2. Congruent MRI and near-infrared spectroscopy for functional and structural imaging of tumors.

    PubMed

    Gulsen, Gultekin; Yu, Hon; Wang, Jun; Nalcioglu, Orhan; Merritt, Sean; Bevilacqua, Frederic; Durkin, Anthony J; Cuccia, David J; Lanning, Ryan; Tromberg, Bruce J

    2002-12-01

    We present a combined near-infrared diffuse optical spectroscopy (DOS) and Magnetic Resonance Imaging (MRI) system for the study of animal model tumors. A combined broadband steady-state and frequency domain optical spectroscopy apparatus was integrated with the MRI. The physiological properties of tissue rendered by MRI, including vascular volume fraction and water, were compared with chromophore concentrations as determined from the parameters obtained by optical measurements. DOS measurements provided oxy-hemoglobin, deoxy-hemoglobin, and water concentration locally in tumors. A method for co-registration of the information obtained by both modalities was developed. Using Monte Carlo simulations, the optically sampled volume was superimposed on the MR images, illustrating which tissue structure was probed optically. Finally, two optical contrast agents, indocyanine green (ICG) and methylene blue (MB), were employed and their kinetics were measured by DOS system from different locations on the tumor and compared with Gd-DTPA enhancement maps obtained from MRI.

  3. Electronic states of zigzag graphene nanoribbons with edges reconstructed with topological defects

    NASA Astrophysics Data System (ADS)

    Pincak, R.; Smotlacha, J.; Osipov, V. A.

    2015-10-01

    The energy spectrum and electronic density of states (DOS) of zigzag graphene nanoribbons with edges reconstructed with topological defects are investigated within the tight-binding method. In case of the Stone-Wales zz(57) edge the low-energy spectrum is markedly changed in comparison to the pristine zz edge. We found that the electronic DOS at the Fermi level is different from zero at any width of graphene nanoribbons. In contrast, for ribbons with heptagons only at one side and pentagons at another one the energy gap at the Fermi level is open and the DOS is equal to zero. The reason is the influence of uncompensated topological charges on the localized edge states, which are topological in nature. This behavior is similar to that found for the structured external electric potentials along the edges.

  4. Carbohydrates in diversity-oriented synthesis: challenges and opportunities.

    PubMed

    Lenci, E; Menchi, G; Trabocchi, A

    2016-01-21

    Over the last decade, Diversity-Oriented Synthesis (DOS) has become a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways, and to provide a larger array of the chemical space. Drug discovery and chemical biology are taking advantage of DOS approaches to exploit highly-diverse and complex molecular platforms, producing advances in both target and ligand discovery. In this view, carbohydrates are attractive building blocks for DOS libraries, due to their stereochemical diversity and high density of polar functional groups, thus offering many possibilities for chemical manipulation and scaffold decoration. This review will discuss research contributions and perspectives on the application of carbohydrate chemistry to explore the accessible chemical space through appendage, stereochemical and scaffold diversity.

  5. Tuning the electronic and optical properties of graphene and boron-nitride quantum dots by molecular charge-transfer interactions: a theoretical study.

    PubMed

    Bandyopadhyay, Arkamita; Yamijala, Sharma S R K C; Pati, Swapan K

    2013-09-01

    Spin-polarized first-principles calculations have been performed to tune the electronic and optical properties of graphene (G) and boron-nitride (BN) quantum dots (QDs) through molecular charge-transfer using tetracyanoquinodimethane (TCNQ) and tetrathiafulvalene (TTF) as dopants. From our results, based on the formation energy and the distance between QDs and dopants, we infer that both the dopants are physisorbed on the QDs. Also, we find that GQDs interact strongly with the dopants compared to the BNQDs. Interestingly, although the dopants are physisorbed on QDs, their interactions lead to a decrement in the HOMO-LUMO gap of QDs by more than half of their original value. We have found a spin-polarized HOMO-LUMO gap in certain QD-dopant complexes. Mülliken population analysis, generation of density of states (DOS) and projected DOS (pDOS) plots, and optical conductivity calculations have been performed to support and understand the reasons behind our findings.

  6. [Slaves and citizens on Ilha Grande: the dawning of the Republic came slowly].

    PubMed

    Schnoor, Eduardo Cavalcanti

    2012-12-01

    The article introduces Ilha Grande, a district in the municipality of Angra dos Reis, and describes its role within the subsistence market economy and the memory of slavery as found in the Angra dos Reis Civil Records. According to the Almanaque Laemmert, this district had the largest number of slaves in the municipality as of the 1870s. Most owners had few slaves, and the majority of landholdings were small. The Angra dos Reis Civil Records did not forget slavery after May 1888. A number of birth and death notifications describe the persons in question as former slaves. Even in the twentieth century, clerks continued to describe various republican citizens as ex-slaves.

  7. [Slaves and citizens on Ilha Grande: the dawning of the Republic came slowly].

    PubMed

    Schnoor, Eduardo Cavalcanti

    2012-12-01

    The article introduces Ilha Grande, a district in the municipality of Angra dos Reis, and describes its role within the subsistence market economy and the memory of slavery as found in the Angra dos Reis Civil Records. According to the Almanaque Laemmert, this district had the largest number of slaves in the municipality as of the 1870s. Most owners had few slaves, and the majority of landholdings were small. The Angra dos Reis Civil Records did not forget slavery after May 1888. A number of birth and death notifications describe the persons in question as former slaves. Even in the twentieth century, clerks continued to describe various republican citizens as ex-slaves. PMID:23370108

  8. Universal Non-Debye Scaling in the Density of States of Amorphous Solids

    NASA Astrophysics Data System (ADS)

    Charbonneau, Patrick; Corwin, Eric I.; Parisi, Giorgio; Poncet, Alexis; Zamponi, Francesco

    2016-07-01

    At the jamming transition, amorphous packings are known to display anomalous vibrational modes with a density of states (DOS) that remains constant at low frequency. The scaling of the DOS at higher packing fractions remains, however, unclear. One might expect to find a simple Debye scaling, but recent results from effective medium theory and the exact solution of mean-field models both predict an anomalous, non-Debye scaling. Being mean-field in nature, however, these solutions are only strictly valid in the limit of infinite spatial dimension, and it is unclear what value they have for finite-dimensional systems. Here, we study packings of soft spheres in dimensions 3 through 7 and find, away from jamming, a universal non-Debye scaling of the DOS that is consistent with the mean-field predictions. We also consider how the soft mode participation ratio evolves as dimension increases.

  9. Universal Non-Debye Scaling in the Density of States of Amorphous Solids.

    PubMed

    Charbonneau, Patrick; Corwin, Eric I; Parisi, Giorgio; Poncet, Alexis; Zamponi, Francesco

    2016-07-22

    At the jamming transition, amorphous packings are known to display anomalous vibrational modes with a density of states (DOS) that remains constant at low frequency. The scaling of the DOS at higher packing fractions remains, however, unclear. One might expect to find a simple Debye scaling, but recent results from effective medium theory and the exact solution of mean-field models both predict an anomalous, non-Debye scaling. Being mean-field in nature, however, these solutions are only strictly valid in the limit of infinite spatial dimension, and it is unclear what value they have for finite-dimensional systems. Here, we study packings of soft spheres in dimensions 3 through 7 and find, away from jamming, a universal non-Debye scaling of the DOS that is consistent with the mean-field predictions. We also consider how the soft mode participation ratio evolves as dimension increases. PMID:27494482

  10. [Attitudes and beliefs regarding opioid maintenance treatment in Portugal: a survey to physicians, patients and opioid users].

    PubMed

    Goulão, João

    2013-01-01

    Introdução: Existem poucos estudos pan-europeus sobre programas terapêuticos com agonistas opiáceos, tanto da perspectiva dos prescritores, como dos doentes que os recebem e dos utilizadores de opióides que se mantêm fora do sistema de tratamento. O projecto ACCESS, um estudo europeu realizado em 11 países, explorou as atitudes e percepções dos médicos, doentes e utilizadores de opióides quanto à qualidade e ao acesso aos programas terapêuticos com agonistas opiáceos. O presente artigo descreve os principais resultados para Portugal.Material e Métodos: Os médicos que tratam doentes dependentes de opióides com recurso a programas terapêuticos com agonistas opiáceos foram inquiridos por entrevista directa; os doentes em programas terapêuticos com agonistas opiáceos, os doentes que não se encontravam em programas terapêuticos com agonistas opiáceos (em tratamento não farmacológico), e os utilizadores activos (pessoas dependentes de opióides que não se encontram actualmente em tratamento) receberam questionários de auto-preenchimento.Resultados: Verificou-se que, tanto os médicos como os doentes avaliam como ‘Bom’ o tratamento dos dependentes de opióides, em Portugal. O acesso ao tratamento foi considerado ‘Fácil’ pela maioria dos doentes e dos médicos, registando-se um elevado nível de satisfação entre os doentes. Contudo, o conhecimento dos doentes quanto às opções dos programas terapêuticos com agonistas opiáceos em Portugal encontra-se ainda abaixo do nível óptimo e as doses dos fármacos dos programas terapêuticos com agonistas opiáceos são frequentemente baixas.Discussão: Os resultados do projecto ACCESS, no que diz respeito a PTAO, são encorajadores e evidenciam quer as áreas de sucesso, quer as áreas que podem ser melhoradas no futuro, no que diz respeito ao sistema de tratamento de dependências de opióides em Portugal.Conclusões: O projecto ACCESS faz uma avaliação importante das atitudes e percep

  11. A Concepção de Universo entre Alunos do Ensino Médio de São Paulo e suas Fontes de Aquisição

    NASA Astrophysics Data System (ADS)

    Araújo, M. A. A.; Elias, D. C. N.; Amaral, L. H.; Araújo, M. S. T.; Voelzke, M. R.

    2006-08-01

    Nesse trabalho procurou-se identificar por meio de um questionário as concepções de Universo, de espaço e tempo que sustentam a visão de mundo de um grupo de 270 estudantes de Ensino Médio, pertencentes a três escolas de São Paulo. As questões relacionadas aos conhecimentos prévios dos estudantes permitiram constatar que há pouco conhecimento acerca dos temas investigados, destacando-se que apenas 20% dos alunos foram capazes de relacionar as semanas com as fases da lua, enquanto 28% associaram as estações do ano à inclinação do eixo de rotação da Terra e 23% tinham noções das distâncias entre objetos celestes próximos da Terra. Enquanto 56% conseguiram relacionar o Big Bang com a origem do Universo, verificou-se que 37% reconheciam ano-luz como unidade de distância e 60% concebiam o Sol como uma estrela. No que se refere às fontes de aquisição que proporcionaram esses conhecimentos, apesar de 60% dos alunos indicarem a escola como principal fonte dos conhecimentos de Ast! ronomia, verificou-se claramente que para a maioria dos alunos seus conceitos ainda são inadequados, havendo necessidade de aprimoramento da abordagem desses conteúdos, pois apesar de popular, a Astronomia ainda é veiculada de maneira pouco esclarecedora e com imprecisões. Nesse contexto, são discutidas algumas possíveis contribuições que podem ser dadas para o ensino de Astronomia pelo uso das ferramentas computacionais nas escolas.

  12. Validation and Visualization of Two-Dimensional Optical Spectroscopic Imaging of Cerebral Hemodynamics

    PubMed Central

    Sheth, Sameer A.; Prakash, Neal; Guiou, Michael; Toga, Arthur W.

    2009-01-01

    Perfusion-based functional brain imaging techniques such as fMRI and optical intrinsic signal (OIS) imaging are becoming increasingly important in both neuroscience research and intraoperative brain mapping. Recent studies have applied a spectroscopic approach to OIS imaging data, which we will call “two-dimensional optical spectroscopy” (2DOS), generating images of functional changes in hemoglobin oxygenation and blood volume. This improvement comes at the cost of several assumptions. Whereas the “gold standard” technique of fiber spectroscopy decomposes reflected light over a spectral axis, 2DOS retains both spatial dimensions by acquiring images at several wavelengths, sacrificing spectral resolution for the extra spatial dimension. Furthermore, 2DOS data are acquired interleaved within or between trials, but combined during the spectroscopic analysis as if acquired simultaneously. Thus far, the few studies employing this approach have assumed both that the reduced spectral resolution is tolerable, and that sufficient trial averaging can compensate for the temporally staggered data acquisition. To test these assumptions, we compared 2DOS results to those produced by traditional fiber spectroscopy by observing the hemodynamic response to hindpaw electrical stimulation over the primary somatosensory cortex in anesthetized rats. Comparisons revealed low fitting residuals and a high level of correlation between the two, but noteworthy differences in response magnitudes. Inspection of individual timecourses revealed a lower signal-to-noise ratio for 2DOS data. For visualization and interpretation of the 2DOS images, we present a parameterized visualization strategy, in which oxy-, deoxy-, and total hemoglobin are assigned to individual color channels. The resulting composite image conveniently displays the evolution of hemodynamic responses through parenchymal and vascular compartments in space and time. PMID:19013531

  13. AKT (protein kinase B) is implicated in meiotic maturation of porcine oocytes.

    PubMed

    Kalous, Jaroslav; Kubelka, Michal; Solc, Petr; Susor, Andrej; Motlík, Jan

    2009-10-01

    The aim of this study was to investigate the involvement of the serine/threonine protein kinase AKT (also called protein kinase B) in the control of meiosis of porcine denuded oocytes (DOs) matured in vitro. Western blot analysis revealed that the two principal AKT phosphorylation sites, Ser473 and Thr308, are phosphorylated at different stages of meiosis. In freshly isolated germinal vesicle (GV)-stage DOs, Ser473 was already phosphorylated. After the onset of oocyte maturation, the intensity of the Ser473 phosphorylation increased, however, which declined sharply when DOs underwent GV breakdown (GVBD) and remained at low levels in metaphase I- and II-stage (MI- and MII-stage). In contrast, phosphorylation of Thr308 was increased by the time of GVBD and reached maximum at MI-stage. A peak of AKT activity was noticed around GVBD and activity of AKT declined at MI-stage. To assess the role of AKT during meiosis, porcine DOs were cultured in 50 microM SH-6, a specific inhibitor of AKT. In SH-6-treated DOs, GVBD was not inhibited; on the contrary, a significant acceleration of meiosis resumption was observed. The dynamics of the Ser473 phosphorylation was not affected; however, phosphorylation of Thr308 was reduced, AKT activity was diminished at the time of GVBD, and meiotic progression was arrested in early MI-stage. Moreover, the activity of the cyclin-dependent kinase 1 (CDK1) and MAP kinase declined when SH-6-treated DOs underwent GVBD, indicating that AKT activity is involved in the regulation of CDK1 and MAP kinase. These results suggest that activity of AKT is not essential for induction of GVBD in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.

  14. Electron spectroscopy of selected atmospheric molecules and hydrocarbons

    NASA Astrophysics Data System (ADS)

    Davies, Julia Ann

    The thesis presents experimental results obtained by electron impact energy-loss spectroscopy. Differential oscillator strengths (DOS) of selected atmospheric molecules and hydrocarbons and vibrational excitation cross sections of ozone are measured. A critical comparison with earlier experiments and theory (where it exists) is made. The thesis is arranged in seven chapters. The first discusses molecular structure, spectroscopy and electron-molecule scattering as is relevant to the scope of this thesis. The next two chapters describe the experimental apparatus used. A high resolution electron spectrometer produces an electron beam (˜10 nA) incident upon the molecular target. Scattered electrons of selected energy-loss and scattering angle are detected by the spectrometer providing a total apparatus resolution of ˜50 meV. The vacuum system, gas inlet system and power supplies are also discussed. Chapters 4, 5 and 6 contain the main results obtained during postgraduate studies. DOS of selected atmospheric molecules (O2, N2, N2O, CO and CO2) are presented and critically compared with previous optical and synchrotron studies. Good agreement between results validates the experimental apparatus and techniques used in this work. A detailed study of the DOS of small alkanes (CH4, C2H6, C3H8 and C4H10) and small alkenes (C2H4, C3H6 and C4H8) shows similarities and trends in these series. DOS of ozone, O3, are also measured and the vibrational excitation of ozone is investigated as a function of scattering angle (40° ≤ theta ≤ 120°) and inccident energy (3 eVDOS data for chlorine dioxide (OClO), a stratospheric molecule of importance in ozone chemistry. Suggestions for future work, such as an investigation into the effects of temperature on DOS spectra for atmospheric molecules, are also presented.

  15. Calculating reliability measures for ordinal data.

    PubMed

    Gamsu, C V

    1986-11-01

    Establishing the reliability of measures taken by judges is important in both clinical and research work. Calculating the statistic of choice, the kappa coefficient, unfortunately is not a particularly quick and simple procedure. Two much-needed practical tools have been developed to overcome these difficulties: a comprehensive and easily understood guide to the manual calculation of the most complex form of the kappa coefficient, weighted kappa for ordinal data, has been written; and a computer program to run under CP/M, PC-DOS and MS-DOS has been developed. With simple modification the program will also run on a Sinclair Spectrum home computer.

  16. Transition to turbulence in a flow of a shear-thinning viscoelastic solution in a Taylor-Couette cell.

    PubMed

    Latrache, Noureddine; Crumeyrolle, Olivier; Mutabazi, Innocent

    2012-11-01

    The transition to turbulence in a flow of semidilute shear-thinning viscoelastic solution with a moderate elasticity was investigated in the Taylor-Couette system with a fixed outer cylinder. As the cylinder rotation frequency increases, the base flow bifurcates to a pattern of ribbons and then to disordered oscillations (DOs). Within these DOs, we have identified two particular regimes of turbulence: spatiotemporal intermittency (STI) followed by inertioelastic turbulence (IET) with a net transition between them. This transition is evidenced by a sharp peak of a diffusion velocity and a Weissenberg number.

  17. Malignant Small Bowel Tumors: Diagnosis, Management and Prognosis.

    PubMed

    Cardoso, Hélder; Rodrigues, João Tiago; Marques, Margarida; Ribeiro, Armando; Vilas-Boas, Filipe; Santos-Antunes, João; Rodrigues-Pinto, Eduardo; Silva, Marco; Maia, José Costa; Macedo, Guilherme

    2015-01-01

    Introdução: Apesar de entidades raras, a incidência dos tumores malignos do intestino delgado parece estar a aumentar. O desenvolvimento da cápsula endoscópica e da enteroscopia assistida por balão permitiram um avanço na avaliação das lesões do intestino delgado. Temos como objetivo descrever as características clínicas e patológicas dos doentes com cancro do intestino delgado e averiguar o papel que estas técnicas endoscópicas assumem atualmente. Material e Métodos: Foi realizado um estudo retrospetivo dos doentes diagnosticados com cancro do intestino delgado, desde janeiro de 2010 até outubro de 2014. Os dados foram submetidos a análise estatística. Resultados: Dos 28 doentes diagnosticados, 54% eram do sexo feminino. A idade média ao diagnóstico foi de 61 anos. O tumor mais frequente foi o adenocarcinoma (n = 11), seguido do sarcoma (n = 6), linfoma (n = 6) e tumores neuroendócrinos (n = 3). A principal forma de apresentação esteve relacionada com perdas hemáticas ou obstrução intestinal. Ao diagnóstico, 46% dos doentes tinhammetástases distantes/tumor irressecável. A maioria dos tumores foi diagnosticada por técnicas endoscópicas (41%) ou imagiológicas (35%). No primeiro ano após o diagnóstico, 29% dos doentes faleceram. Na análise multivariada, o adenocarcinoma permaneceu fator independente para pior sobrevida. Discussão: Os doentes com adenocarcinoma apresentaram-se em estádios tardios e com tumores irressecáveis, contribuindo para um pior prognóstico. Ã necessário um elevado grau de suspeita clínica para o diagnóstico de cancro do intestino delgado. Conclusão: As características dos doentes foram globalmente consistentes com o descrito na literatura. A cápsula endoscópica e a enteroscopia assistida por balão são úteis no diagnóstico, gestão e vigilância do cancro do intestino delgado.

  18. Condensation of fermion zero modes in the vortex

    NASA Astrophysics Data System (ADS)

    Volovik, G. E.

    2016-08-01

    The energy levels of the fermions bound to the vortex are considered for vortices in the superfluid/superconducting systems which contain the symmetry protected plane of zeroes in the gap function in bulk. The Caroli-de Gennes-Matricon branches with different n approach zero energy level at p z → 0. The density of states of the bound fermions diverges at zero energy giving rise to the √ Ω dependence of DoS in the polar phase of superfluid 3He rotating with the angular velocity Ω and to the √ B dependence of DoS for superconductors in the (d xz + id yz )-wave pairing state.

  19. A photoelectron spectroscopy study of the electronic structure evolution in CuInSe{sub 2}-related compounds at changing copper content

    SciTech Connect

    Kuznetsova, T. V.; Grebennikov, V. I.; Zhao, H.; Derks, C.; Taubitz, C.; Neumann, M.; Persson, C.; Kuznetsov, M. V.; Bodnar, I. V.; Martin, R. W.; Yakushev, M. V.

    2012-09-10

    Evolution of the valence-band structure at gradually increasing copper content has been analysed by x-ray photoelectron spectroscopy (XPS) in In{sub 2}Se{sub 3}, CuIn{sub 5}Se{sub 8}, CuIn{sub 3}Se{sub 5}, and CuInSe{sub 2} single crystals. A comparison of these spectra with calculated total and angular-momentum resolved density-of-states (DOS) revealed the main trends of this evolution. The formation of the theoretically predicted gap between the bonding and non-bonding states has been observed in both experimental XPS spectra and theoretical DOS.

  20. Interactions of aminoglycoside antibiotics with rRNA.

    PubMed

    Trylska, Joanna; Kulik, Marta

    2016-08-15

    Aminoglycoside antibiotics are protein synthesis inhibitors applied to treat infections caused mainly by aerobic Gram-negative bacteria. Due to their adverse side effects they are last resort antibiotics typically used to combat pathogens resistant to other drugs. Aminoglycosides target ribosomes. We describe the interactions of aminoglycoside antibiotics containing a 2-deoxystreptamine (2-DOS) ring with 16S rRNA. We review the computational studies, with a focus on molecular dynamics (MD) simulations performed on RNA models mimicking the 2-DOS aminoglycoside binding site in the small ribosomal subunit. We also briefly discuss thermodynamics of interactions of these aminoglycosides with their 16S RNA target. PMID:27528743

  1. In-Vivo Gene Signatures of Mycobacterium tuberculosis in C3HeB/FeJ Mice

    PubMed Central

    Gautam, Uma Shankar; Mehra, Smriti; Kaushal, Deepak

    2015-01-01

    Despite considerable progress in understanding the pathogenesis of Mycobacterium tuberculosis (Mtb), development of new therapeutics and vaccines against it has proven difficult. This is at least in part due to the use of less than optimal models of in-vivo Mtb infection, which has precluded a study of the physiology of the pathogen in niches where it actually persists. C3HeB/FeJ (Kramnik) mice develop human-like lesions when experimentally infected with Mtb and thus make available, a faithful and highly tractable system to study the physiology of the pathogen in-vivo. We compared the transcriptomics of Mtb and various mutants in the DosR (DevR) regulon derived from Kramnik mouse granulomas to those cultured in-vitro. We recently showed that mutant ΔdosS is attenuated in C3HeB/FeJ mice. Aerosol exposure of mice with the mutant mycobacteria resulted in a substantially different and a relatively weaker transcriptional response (< = 20 genes were induced) for the functional category ‘Information Pathways’ in Mtb:ΔdosR; ‘Lipid Metabolism’ in Mtb:ΔdosT; ‘Virulence, Detoxification, Adaptation’ in both Mtb:ΔdosR and Mtb:ΔdosT; and ‘PE/PPE’ family in all mutant strains compare to wild-type Mtb H37Rv, suggesting that the inability to induce DosR functions to different levels can modulate the interaction of the pathogen with the host. The Mtb genes expressed during growth in C3HeB/FeJ mice appear to reflect adaptation to differential nutrient utilization for survival in mouse lungs. The genes such as glnB, Rv0744c, Rv3281, sdhD/B, mce4A, dctA etc. downregulated in mutant ΔdosS indicate their requirement for bacterial growth and flow of carbon/energy source from host cells. We conclude that genes expressed in Mtb during in-vivo chronic phase of infection in Kramnik mice mainly contribute to growth, cell wall processes, lipid metabolism, and virulence. PMID:26270051

  2. High-Resolution Soft X-Ray Spectral Analysis in the CK Region of Titanium Carbide (TiC) using the DV-X alpha Molecular Orbital Method

    SciTech Connect

    Shimomura, Kenta; Muramatsu, Yasuji; Denlinger, Jonathan D.; Gullikson, Eric M.

    2008-10-31

    We used the DV-X alpha method to analyze the high-resolution soft X-ray emission and absorption spectra in the CK region of titanium carbide (TiC). The spectral profiles of the X-ray emission and absorption can be ssuscfucelly reproduced by the occupied and unoccupied density of states (DOS ), respectively, in the C2p orbitals of the center carbon atoms in a Ti62C63 cluster model, suggesting that the center carbon atom in a large cluster model expanded to the cubic-structured 53 (= 125) atoms provides sufficient DOS for the X-ray spectral analysis of rock-salt structured metal carbides.

  3. Microscopic theory of the Andreev gap.

    SciTech Connect

    Micklitz, T.; Altland, A.; Materials Science Division; Univ. zu Koln

    2009-01-01

    We present a microscopic theory of the Andreev gap, i.e., the phenomenon that the density of states (DOS) of normal chaotic cavities attached to superconductors displays a hard gap centered around the Fermi energy. Our approach is based on a solution of the quantum Eilenberger equation in the regime t{sub D} << t{sub E} where t{sub D} and t{sub E} are the classical dwell time and Ehrenfest time, respectively. We show how quantum fluctuations eradicate the DOS at low energies and compute the profile of the gap to leading order in the parameter t{sub D}/t{sub E}.

  4. Microscopic theory of the Andreev gap.

    PubMed

    Micklitz, Tobias; Altland, Alexander

    2009-08-21

    We present a microscopic theory of the Andreev gap, i.e., the phenomenon that the density of states (DOS) of normal chaotic cavities attached to superconductors displays a hard gap centered around the Fermi energy. Our approach is based on a solution of the quantum Eilenberger equation in the regime tDDOS at low energies and compute the profile of the gap to leading order in the parameter tD/tE.

  5. Probing the Electronic Density of States of Germanium Nanoparticles: A Method for Determining Atomic Structure

    SciTech Connect

    Williamson, A; Bostedt, C; van Buuren, T; Willey, T; Terminello, L; Galli, G; Pizzagalli, L

    2004-03-31

    We present first principles electronic structure calculations and photoemission measurements of the change in the valence band DOS of germanium as its dimensions are reduced from the bulk to the nanoscale. By comparing the calculated broadening of the s and s--p band peaks and the energy of surface dangling bonds to the measured DOS we identify the most likely structure of these nanoparticles. We propose that, in contrast to recent interpretations, small 2-3 nm germanium nanoparticles prepared by gas phase aggregation have a distorted diamond structure core and a thermally disordered surface.

  6. [Career Satisfaction of Medical Residents in Portugal].

    PubMed

    Martins, Maria João; Laíns, Inês; Brochado, Bruno; Oliveira-Santos, Manuel; Teixeira, Pedro Pinto; Brandão, Mariana; Cerqueira, Rui João; Castro-Ferreira, Ricardo; Bernardes, Carlos; Menezes, Miguel Nobre; Baptista, Bernardo Soares; Ladeiras-Lopes, Ricardo; Rei, Mariana Cruz; Rosa, Gilberto Pires da; Martins, José Luís; Mendonça Sanches, Maria; Ferreira-Pinto, Manuel J; Rato, Margarida; Costa e Silva, Miguel; Policiano, Catarina; Beato, João; Barbosa-Breda, João; Torres, João Pimentel; Leal, Inês; Rosa, Sílvia Aguiar; Ribeiro, Bárbara Carvalho; Costa, Francisco Rego; Palmela, Carolina; Gonçalves, Tiago Cúrdia; Morais, Luis; Marques, Tiago Reis

    2015-01-01

    Introdução: A satisfação com a profissão médica tem sido apontada como um fator essencial para a qualidade assistencial, o bemestar dos doentes e a estabilidade dos sistemas de saúde. Estudos recentes têm vindo a enfatizar um crescente descontentamento dos médicos, principalmente como consequência das alterações das relações laborais.Objetivos: Avaliar a perceção dos médicos de formação específica em Portugal, sobre as expectativas e grau de satisfação com a profissão, especialidade e local de formação; razões da insatisfação e intenção de emigrar.Material e Métodos: Estudo transversal. A colheita de dados foi efetuada entre Maio e Agosto de 2014 através de um Inquérito online sobre a âÄúSatisfação com a EspecialidadeâÄù.Resultados: De uma população total de 5788 médicos, foram obtidas 804 respostas (12,25% do total de médicos internos). Desta amostra, 77% das respostas correspondem a internos dos três primeiros anos de formação. Verificou-se que 90% dos médicos se encontram satisfeitos com a especialidade, tendo-se encontrado também níveis elevados de satisfação com a profissão (85%) e local de formação (86%). Por outro lado, constatou-se que estes diminuíam com a progressão ao longo dos anos de internato. A avaliação global sobre o panorama da prática médica foi negativa e 65% dos médicos responderam que consideram emigrar após conclusão do internato.Conclusão: Os médicos internos em Portugal apresentam níveis positivos de satisfação com a sua profissão. No entanto, a sua opinião sobre o panorama da Medicina e os resultados relativos à intenção de emigrar alertam para a necessidade de tomada de medidas para inverter este cenário.

  7. Adsorbate-induced quantum Hall system probed by scanning tunneling spectroscopy combined with transport measurements

    SciTech Connect

    Masutomi, Ryuichi Okamoto, Tohru

    2015-06-22

    An adsorbate-induced quantum Hall system at the cleaved InSb surfaces is investigated in magnetic fields up to 14 T using low-temperature scanning tunneling microscopy and spectroscopy combined with transport measurements. We show that an enhanced Zeeman splitting in the Shubnikov-de Haas oscillations is explained by an exchange enhancement of spin splitting and potential disorder, both of which are obtained from the spatially averaged density of states (DOS). Moreover, the Altshuler–Aronov correlation gap is observed in the spatially averaged DOS at 0 T.

  8. Surface X-ray emission from lanthanide metals

    NASA Astrophysics Data System (ADS)

    Hübinger, F.; Shulakov, A. S.; Starke, K.; Grigoriev, A.; Kaindl, G.

    2003-02-01

    O 3 X-ray emission (XE) upon 5p 3/2 electron-impact ionization of La(0 0 0 1) and Sm(0 0 0 1) metal surfaces exhibits up to 30% spectral intensity from the topmost atomic surface layer. The energy separation of surface and bulk XE peaks is explained by the surface core-level shift of La and the surface valence transition of Sm. While the bulk XE spectra are in reasonable agreement with theoretical sd partial density of states (DOS), the experimental access to the partial surface-layer DOS opens new opportunities in studying surface phenomena in lanthanide metals and compounds.

  9. Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis

    PubMed Central

    He, Rongjun; Bai, Yunpeng; Yu, Zhi-Hong; Wu, Li; Gunawan, Andrea Michelle; Zhang, Zhong-Yin

    2014-01-01

    Mycobacterium protein tyrosine phosphatase B (mPTPB) is a potential drug target of Tuberculosis (TB). Small molecule inhibitors of mPTPB could be a treatment to overcome emerging TB drug resistance. Using a Diversity-Oriented Synthesis (DOS) strategy, we successfully developed a salicylic acid based and drug-like mPTPB inhibitor with an IC50 of 2 μM and >20-fold specificity over many human PTPs, making it an excellent lead molecule for anti-TB drug discovery. In addition, DOS generated bicyclic salicylic acids are also promising starting points for acquiring inhibitors targeting other PTPs. PMID:25505942

  10. Dependence of mobility on density of gap states in organics by GAMEaS-gate modulated activation energy spectroscopy

    NASA Astrophysics Data System (ADS)

    So, Woo-young; Lang, David V.; Butko, Vladimir Y.; Chi, Xiaoliu; Lashley, Jason C.; Ramirez, Arthur P.

    2008-09-01

    We develop a broadly applicable transport-based technique, gate modulated activation energy spectroscopy (GAMEaS), for determining the density of states (DOS) in an energy gap. GAMEaS is applied to field-effect transistors (FETs) made from different single crystal oligomer semiconductors. We find that there are two distinct types of band tails, deep and shallow, depending on the crystallization process. The exponential band tails of the localized DOS are characterized by their slope with the highest mobility FETs having a value of 29 eV-1 close to 1/kBT at 300 K.

  11. Effect of Densification on the Density of Vibrational States of Glasses

    SciTech Connect

    Monaco, A.; Chumakov, A. I.; Monaco, G.; Crichton, W. A.; Rueffer, R.; Meyer, A.; Comez, L.; Fioretto, D.; Korecki, J.

    2006-09-29

    We studied the effect of densification on the vibrational dynamics of a Na{sub 2}FeSi{sub 3}O{sub 8} glass. The density of vibrational states (DOS) has been measured using nuclear inelastic scattering. The corresponding changes in the microscopic, intermediate-range, and macroscopic properties have also been investigated. The results reveal that, in the absence of local structure transformations, the Debye level and the glass-specific excess of vibrational states above it have the same dependence on density, and the evolution of the DOS is fully described by the transformation of the elastic medium.

  12. Adapting a Common Photographic Camera to Take Pictures of the Sky. (Spanish Title: Adaptando Una Camara Fotografica Comun Para Obtener Fotografias del Cielo.) Adaptando Uma Câmera Fotográfica Manual Simples Para Fotografar o Céu

    NASA Astrophysics Data System (ADS)

    Danhoni Neves, Marcos Cesar; Pereira, Ricardo Francisco

    2007-12-01

    In this paper will be introduced a method of astrophotography using a non-reflex photographic camera (a low-cost method). It will be revised some photographic processes commonly used nowadays for comparison with the aims of this paper. En este trabajo será introducido un método de astrofotografia que utiliza una cámara fotográfica non-reflex (un método de bajo costo). Serán revisados algunos procesos fotográficos comúnmente utilizados actualmente para comparación con los objetivos de este trabajo. O presente artigo procura introduzir um método de astrofotografia utilizando uma câmera fotográfica não reflex, de baixo custo. É feita uma revisão do processo fotográfico comumente empregado para fins de comparação com os objetivos pretendidos no presente trabalho.

  13. Determination of the Galactic Rotation Curve Based on Planetary Nebulae

    NASA Astrophysics Data System (ADS)

    Diara, C. M.; Maciel, W. J.

    1990-11-01

    ABSTRACT:Planetary nebulae of types I, lIa, and llb are considered in order to determine the galactic rotation curve. It is shown that the curves defined by the first two types do not differ substantially from the one derived on the basis of young population I objects, such as CO-H II molecular complexes. RESUMO:Um grupo de nebulosas planetarias de tipos I, lIa, e lIb e utilizado para determinar a curva de rota o galatica. Mostra-se que as curvas definidas pelos dois primeiros tipos de nebulosas diferem substancialmente da curva obtida a partir de objetos jovens, de popuIa o I, como Os complexos moleculares CO-H II. Koy words: GALAXY-STRUCTURE - NEBULAE-PLANETARY

  14. [Endovascular treatment of critical basilar stenosis with a Solitaire® stent device: a first experience in our centre].

    PubMed

    Mulero, Patricia; Cortijo-García, Elisa; Ruiz-Piñero, Marina; Pérez-Fernández, Santiago; Arenillas-Lara, Juan F; Martínez-Galdámez, Mario

    2014-08-01

    Introduccion. Aunque la arterioesclerosis intracraneal es una causa importante de ictus, la actitud terapeutica no esta claramente establecida. En este sentido, el estudio SAMMPRIS comparo el tratamiento medico intensivo con la angioplastia y colocacion de stent, con resultados favorables al tratamiento farmacologico. Estos resultados podrian, en parte, deberse al dispositivo utilizado (stent Wingspan ®). Caso clinico. Varon de 71 años con una estenosis grave de la arteria basilar, en quien se repetian episodios de focalidad neurologica transitoria a pesar del tratamiento con doble antiagregacion y estatinas. En estas circunstancias se decidio realizar una arteriografia terapeutica con angioplastia y colocacion de un stent Solitaire ® para optimizar resultados y se logro una estenosis residual del 40%. La evolucion fue favorable y los controles posteriores muestran una minima progresion. Conclusion. Segun nuestro conocimiento, este es el primer caso publicado de tratamiento de una estenosis critica de la arteria basilar mediante la colocacion de un stent Solitaire ®.

  15. [Electrical status epilepticus during sleep: a retrospective multi-centre study of 29 cases].

    PubMed

    Lorenzo-Ruiz, María; Miguel-Martin, Beatriz; García-Pérez, Asunción; Martínez-Granero, Miguel A; Aguilera-Albesa, Sergio; Yoldi-Petri, M Eugenia; Sánchez-Ruiz de Gordoa, Javier; Castro-De Castro, Pedro; Sánchez-Carpintero, Rocío

    2015-02-01

    Introduccion. El estado epileptico electrico durante el sueño (ESES) es un sindrome epileptico caracterizado por la presencia de descargas epilepticas tipo punta-onda lenta de manera muy persistente durante el sueño no REM. En la actualidad, el manejo de esta patologia es heterogeneo y no hay estudios controlados con los tratamientos utilizados, ni se ha comprobado si estos mejoran la evolucion cognitiva de los pacientes. Pacientes y metodos. Se revisan los pacientes diagnosticados de ESES durante 15 años en cuatro centros hospitalarios, se recoge la presentacion clinica, el manejo terapeutico y la evolucion clinica, y se compara con la bibliografia. Resultados. Se seleccionaron 29 pacientes con ESES, 20 de ellos idiopatico y 26 de ellos generalizado. Los farmacos con los que se consiguio mayor control de la actividad electrica fueron los corticoides/hormona adrenocorticotropa (ACTH), el clobazam y el levetiracetam. La mediana de duracion del ESES en los casos primarios fue de seis meses, y en los secundarios, el doble. El 45% de los pacientes mantuvo un cociente intelectual normal y un 40% presento en la evolucion discapacidad cognitiva de diferente grado. Conclusiones. El pronostico neuropsicologico evolutivo suele ser desfavorable y la evolucion cognitiva parece estar en relacion con la duracion del ESES y el area donde este concentrada la actividad epileptica, lo que sugiere que el mal pronostico, si se trata precozmente, se puede evitar. Los antiepilepticos mas frecuentemente utilizados son el acido valproico, la etosuximida y el levetiracetam, y en nuestra muestra tambien se utilizaron con frecuencia el clobazam y la lamotrigina. Los farmacos mas eficaces para el control del ESES fueron los corticoides/ACTH, el clobazam y el levetiracetam.

  16. [Methods for evaluating large-scale nutrition programs in latin america: an integrative review].

    PubMed

    Álvarez Castaño, Luz Stella; Pérez Isaza, Elsury Johana; Góez Rueda, Juan Diego; Rivera Jaramillo, Ana; Peña Ochoa, Carolina

    2014-12-01

    Introducción: La evaluación de programas es un campo de conocimiento en proceso de consolidación en el cual intervienen diferentes disciplinas y que utiliza herramientas de la investigación social aunque tiene objetivos particulares que la distinguen de ella. Objetivo: Identificar los diseños metodológicos con los que se están evaluando los programas nutricionales en América Latina, incluyendo los tipos de estudio realizados en las evaluaciones, las dimensiones evaluadas y los indicadores utilizados. Metodología: Se realizó una revisión integrativa. Se revisaron diferentes bases de datos electrónicas, se realizó una búsqueda manual y se consultaron páginas web institucionales. Resultados: Se analizaron 92 evaluaciones de 40 programas; se encontró que en la mayoría de los casos no es explicito el diseño metodológico utilizado en la evaluación. En aquellos casos en que si se hace, se evidencian tres diseños mayormente aplicados: consistencia y resultados, modelo multidimensional y la triangulación de métodos. Las dimensiones que comúnmente se evalúan son el impacto y los resultados de los programas y en menor medida su estructura y procesos. Los tipos de estudio más usados para medir el impacto de los programas nutricionales continúan siendo de naturaleza cuantitativa especialmente los cuasi-experimentales, sin embargo hay una búsqueda por utilizar herramientas cualitativas que den cuenta de las percepciones de los actores involucrados. Conclusiones: Se encontró interés en algunas instituciones de realizar evaluaciones que se fundamentan en nuevos paradigmas y exploran combinación de métodos, objetivos e indicadores.

  17. [Translation and adaptation to Spanish language of the quality of life questionnaire for celiac people called Canadian Celiac Health Survey].

    PubMed

    Pelegrí, Cristina; Mañes, Jordi; Soriano, Jose Miguel

    2014-10-01

    Introducción: Adaptar y valorar el cuestionario de calidad de vida denominado Canadian Celiac Health Survey (CCHS). Objetivo: Traducir y adaptar en castellano el cuestionario CCHS para poder ser utilizado por la población de habla hispana puesto que se trata de un cuestionario específico para la celiaquía. Método: La adaptación del CCHS, que consta de 76 ítems distribuidos en 11 secciones diferentes, se realizó mediante el método de traducción-retrotraducción y tras ser revisado y consensuado se procedió a realizar una prueba piloto con 25 personas celíacas, de forma individual y por un miembro del grupo de investigación, para valorar la comprensión de los ítems y sus secciones. Las aportaciones fueron introducidas, configurando el cuestionario definitivo. Resultados: La máxima dificultad en la traducción se produjo en la pregunta donde existían principios activos y nombres comerciales de medicamentos, optándose para ello a los comercializados a nivel nacional. Por otro lado, para el estudio piloto del cuestionario se observó un buen valor de la naturalidad de la comprensión con valores comprendidos entre 8,4 y 10,0. Conclusiones: La herramienta específica CHCS permitirá el uso de un cuestionario que pueda ser utilizado por la población de habla hispana en estudios, ensayos clínicos o en la práctica profesional sanitaria cotidiana, permitiendo un mejor conocimiento del estado de salud de los celíacos.

  18. Identification and In-vivo Characterization of a Novel OhrR Transcriptional Regulator in Burkholderia xenovorans LB400

    DOE PAGES

    Nguyen, Tinh T.; Martí-Arbona, Ricardo; Hall, Richard S.; Maity, Tuhin; Valdez, Yolanda E.; Dunbar, John M.; Unkefer, Clifford J.; Unkefer, Pat J.

    2013-05-21

    Transcriptional regulators (TRs) are an important and versatile group of proteins, yet very little progress has been achieved towards the discovery and annotation of their biological functions. We have characterized a previously unknown organic hydroperoxide resistance regulator from Burkholderia xenovoransLB400, Bxe_B2842, which is homologous to E. coli’s OhrR. Bxe_B2842 regulates the expression of an organic hydroperoxide resistance protein (OsmC). We utilized frontal affinity chromatography coupled with mass spectrometry (FAC-MS) and electrophoretic mobility gel shift assays (EMSA) to identify and characterize the possible effectors of the regulation by Bxe_B2842. Without an effector, Bxe_B2842 binds a DNA operator sequence (DOS) upstream ofmore » osmC. FAC-MS results suggest that 2-aminophenol binds to the protein and is potentially an effector molecule. EMSA analysis shows that 2-aminophenol also attenuates the Bxe_B2842’s affinity for its DOS. EMSA analysis also shows that organic peroxides attenuate Bxe_B2842/DOS affinity, suggesting that binding of the TR to its DOS is regulated by the two-cysteine mechanism, common to TRs in this family. Bxe_B2842 is the first OhrR TR to have both oxidative and effector-binding mechanisms of regulation. Our paper reveals further mechanistic diversity TR mediated gene regulation and provides insights into methods for function discovery of TRs.« less

  19. Physically-based simulation of zinc oxide thin-film transistors: Contact resistance contribution on density of states

    NASA Astrophysics Data System (ADS)

    Dominguez, Miguel A.; Alcantara, Salvador; Soto, Susana

    2016-06-01

    In this work, using a physically-based simulator, the density of states DOS is modeled to reproduce the experimental electrical characteristics of ZnO TFTs fabricated by Ultrasonic Spray Pyrolysis at 200 °C. The contact resistance was experimentally extracted from the ZnO TFTs and included into the simulation, in order to separate the metal-semiconductor interface contribution from the DOS. A comparison between the modeled DOS considering the contact resistance and disregarding it is also presented. It is proposed to consider the acceptor-like states and the tail-donor states, where the deep-acceptor states have approximately an exponential form and the distribution of tail-acceptor states are sharper than the distribution of tail-donor states. The simulated electrical characteristics reproduce very well the experimental data at different channel lengths. The use of physically-based simulation can be useful to model the DOS of Oxide semiconductor films in TFTs by reproducing the experimental data.

  20. 78 FR 63560 - Notice of Receipt of an Application by Magellan Pipeline Company, L.P., for Issuance of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... of Receipt of an Application by Magellan Pipeline Company, L.P., for Issuance of a Presidential... October 18, 2013. AGENCY: Department of State. ACTION: Notice of Receipt of an Application by Magellan... of State (DOS) has received from Magellan Pipeline Company, L.P. (``Magellan'') notice that it...

  1. 27 CFR 9.187 - Covelo.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Covelo viticultural area surrounds the town of Covelo in northern Mendocino County, California. The area... Survey 1:24,000 scale topographic maps. They are titled: (1) Dos Rios, California Quadrangle,—Mendocino...,—Mendocino Co., 7.5 Minute Series, edition of 1967, photoinspected 1973; (3) Covelo East,...

  2. 27 CFR 9.187 - Covelo.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Covelo viticultural area surrounds the town of Covelo in northern Mendocino County, California. The area... Survey 1:24,000 scale topographic maps. They are titled: (1) Dos Rios, California Quadrangle,—Mendocino...,—Mendocino Co., 7.5 Minute Series, edition of 1967, photoinspected 1973; (3) Covelo East,...

  3. 27 CFR 9.187 - Covelo.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Covelo viticultural area surrounds the town of Covelo in northern Mendocino County, California. The area... Survey 1:24,000 scale topographic maps. They are titled: (1) Dos Rios, California Quadrangle,—Mendocino...,—Mendocino Co., 7.5 Minute Series, edition of 1967, photoinspected 1973; (3) Covelo East,...

  4. A CASE STUDY USING THE EPA'S WATER QUALITY MODELING SYSTEM, THE WINDOWS INTERFACE FOR SIMULATING PLUMES (WISP)

    EPA Science Inventory

    Wisp, the Windows Interface for Simulating Plumes, is designed to be an easy-to-use windows platform program for aquatic modeling. Wisp inherits many of its capabilities from its predecessor, the DOS-based PLUMES (Baumgartner, Frick, Roberts, 1994). These capabilities have been ...

  5. Multi Platform Graphics Subroutine Library

    1992-02-21

    DIGLIB is a collection of general graphics subroutines. It was designed to be small, reasonably fast, device-independent, and compatible with DEC-supplied operating systems for VAXes, PDP-11s, and LSI-11s, and the DOS operating system for IBM PCs and IBM-compatible machines. The software is readily usable by casual programmers for two-dimensional plotting.

  6. From Resume to Teaching Job: What You Need to Know

    ERIC Educational Resources Information Center

    Clement, Mary C.

    2012-01-01

    The teacher job market has become very competitive, but the good news is that there are jobs in schools. Candidates who do their homework and work at getting a job with the same dedication they put into earning their teaching licensure will be employable. In this article, the author discusses the the dos and don'ts of the job search--including…

  7. 48 CFR 604.1300 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Policy. 604.1300 Section 604.1300 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL ADMINISTRATIVE MATTERS Personal Identity Verification of Contractor Personnel 604.1300 Policy. The DOS official responsible...

  8. 48 CFR 604.1300 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Policy. 604.1300 Section 604.1300 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL ADMINISTRATIVE MATTERS Personal Identity Verification of Contractor Personnel 604.1300 Policy. The DOS official responsible...

  9. 48 CFR 604.1300 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Policy. 604.1300 Section 604.1300 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL ADMINISTRATIVE MATTERS Personal Identity Verification of Contractor Personnel 604.1300 Policy. The DOS official responsible...

  10. American Osteopathic Association Commitment to Quality and Lifelong Learning

    ERIC Educational Resources Information Center

    Tunanidas, Amelia G.; Burkhart, Diane N.

    2005-01-01

    The American Osteopathic Association (AOA) initiated programs to enhance quality for 54, 000 doctors of osteopathic medicine (DOs) practicing in the United States. Seven core competencies are required in undergraduate and graduate medical education standards. They include osteopathic philosophy and osteopathic manipulative medicine, medical…

  11. 27 CFR 9.187 - Covelo.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... for determining the boundaries of the Covelo viticultural area are four United States Geological Survey 1:24,000 scale topographic maps. They are titled: (1) Dos Rios, California Quadrangle,—Mendocino..., California Quadrangle,—Mendocino Co., 7.5 Minute Series, edition of 1967, revised 1994. (c) Boundary....

  12. Windows Program Information Files. How Windows and Non-Windows Programs Cooperate through PIFs.

    ERIC Educational Resources Information Center

    Marmion, Dan

    1992-01-01

    Describes Program Information Files (PIFs), which run on DOS operating systems with Microsoft Windows to help run other programs. Options available in the standard mode and in the enhanced mode are explained, multitasking options are discussed, and memory options and application shortcut keys are described. (LRW)

  13. Disminuyen en los Estados Unidos las infecciones por VPH.

    Cancer.gov

    La infección por los tipos del virus del papiloma humano (VPH) en el blanco de la vacuna cuadrivalente se redujo en casi dos tercios en las adolescentes desde que se recomendó la vacunación en los Estados Unidos.

  14. FILE: A Program for Cataloging Items.

    ERIC Educational Resources Information Center

    Swindler, Dick L.

    1984-01-01

    Describes a computer program which allows the user to establish and maintain a file of up to 1,000 items. Items are stored alphabetically and may be searched. Copy of the program for Apple II Plus (DOS 3.3) may be obtained by contacting the author. (JN)

  15. Can We Really Make a Difference? Exploring Pre-Service Teachers' Experience with Socio-Scientific Issues Aiming for Democratic Participation in Science

    ERIC Educational Resources Information Center

    Cook, Kristin Leigh

    2012-01-01

    Responding to calls for an empirical glimpse into a socioscientific issues (SSI)-based curriculum that aims to promote democratic participation, enhance students' connections to science, and empower students for the betterment of society (Dos Santos, 2008; Sadler, Barab, & Scott, 2007; Tal & Kedmi, 2006; Fusco & Barton, 2001; Hodson, 2003), this…

  16. COATING ALTERNATIVES GUIDE (CAGE) USER'S GUIDE

    EPA Science Inventory

    The guide provides instructions for using the Coating Alternatives GuidE (CAGE) software program, version 1.0. It assumes that the user is familiar with the fundamentals of operating an IBM-compatible personal computer (PC) under the Microsoft disk operating system (MS-DOS). CAGE...

  17. Riding the Wave to Reach the Masses: Natural Events in Early Twentieth Century Portuguese Daily Press

    ERIC Educational Resources Information Center

    Simoes, Ana; Carneiro, Ana; Diogo, Maria Paula

    2012-01-01

    This paper brings together science communicated in newspapers in Portugal by looking at how news on natural events were communicated in two different newspapers--the capital newspaper "Diario de Noticias" ("Daily News") and the "Diario dos Acores" ("Azores Daily"). In particular, we look at how the 1900 solar eclipse, a hot topic throughout…

  18. Information Release Administration Database (IRAD), Software Design Description (SDD)

    SciTech Connect

    CAREY, D.S.

    2000-05-10

    The IRAD system is a client server system that is written in Paradox for DOS. This system will be replaced with a Visual Basic and SQL Server in order to update the technology, eliminate obsolete functions, as well as to automate the manual interfaces.

  19. Studies in Language Learning and Spanish Linguistics. Festschrift in Honor of Tracy D. Terrell.

    ERIC Educational Resources Information Center

    Hashemipour, Peggy, Ed.; Maldonado, Ricardo, Ed.; van Naerssen, Margaret, Ed.

    Essays on Spanish linguistics and related topics are dedicated to linguist Tracy D. Terrell. An introductory section gives a brief biography and a list of his publications. Essays include: "The Natural Approach to Language Teaching: An Update" (Tracy D. Terrell); "Two Mad, Mad, Mad Worlds: Notes on Natural Approach and the Writing of 'Dos mundos'"…

  20. National Household Education Survey, NHES: 91/93/95 Electronic Codebook (ECB) User's Guide.

    ERIC Educational Resources Information Center

    Westat, Inc., Rockville, MD.

    The National Household Education Survey (NHES) CD-ROM for 1991, 1993, and 1995 contains an Electronic Codebook (ECB) program that allows the user to examine the variables in each of the NHES data sets easily and to create Statistical Analysis system and Statistical Package for the Social Sciences (for DOS or Windows) that will generate an extract…