Bridging Adult Experience to Pediatrics in Oncology Drug Development.
Leong, Ruby; Zhao, Hong; Reaman, Gregory; Liu, Qi; Wang, Yaning; Stewart, Clinton F; Burckart, Gilbert
2017-10-01
Pediatric drug development in the United States has grown under the current regulations made permanent by the Food and Drug Administration Safety and Innovation Act of 2012. Over 1200 pediatric studies have now been submitted to the US FDA, but there is still a high rate of failure to obtain pediatric labeling for the indication pursued. Pediatric oncology represents special problems in that the disease is most often dissimilar to any cancer found in the adult population. Therefore, the development of drug dosing in pediatric oncology patients represents a special challenge. Potential approaches to pediatric dosing in oncology patients include extrapolation of efficacy from adult studies in those few cases where the disease is similar, inclusion of adolescent patients in adult trials when possible, and bridging the adult dose to the pediatric dose. An analysis of the recommended phase 2 dose for 40 molecularly targeted agents in pediatric patients provides some insight into current practices. Increased knowledge of tumor biology and efforts to identify and validate molecular targets and genetic abnormalities that drive childhood cancers can lead to increased opportunities for precision medicine in the treatment of pediatric cancers. © 2017, The American College of Clinical Pharmacology.
Stern, Gretchen; Rimsans, Jessica; Qamar, Arman; Vaduganathan, Muthiah; Bhatt, Deepak L
2018-03-13
Oral antiplatelet therapy may require interruption soon after percutaneous coronary intervention (PCI) or acute coronary syndrome. The optimal parenteral antiplatelet bridge strategy with glycoprotein IIb/IIIa inhibitors or cangrelor, a P2Y12 inhibitor, is unclear. We explore real-world use of cangrelor or eptifibatide for antiplatelet bridging at a large tertiary-care center. Thirty-one patients (9 eptifibatide, 20 cangrelor, and 2 both) received bridge therapy from October 2015 to June 2017. Primary bridge therapy indications included surgery (68%), limited enteral access/absorption (16%), and high-perceived bleed risk (16%). Median duration of bridge therapy was 61 (20-100) hours for cangrelor and 83 (19-98) hours for eptifibatide. Severe/life-threatening bleeding or stent thrombosis was not observed. GUSTO-defined bleeding occurred in 30% (cangrelor) and 27% (eptifibatide). Initial dosing errors occurred in 23% of patients. Death during hospitalization occurred in 16% of patients. Parenteral antiplatelet bridging was used for ~3 days in this single-center, tertiary care experience, commonly for unplanned surgery following PCI. Despite high-risk presentations with >15% in-hospital mortality, efficacy profiles were reassuring with no identified stent thrombosis, but bleeding and dosing errors were common. Antiplatelet bridging should only be used in well-selected patients at the appropriate dose for the minimal necessary duration.
Best Practices for Intrathecal Baclofen Therapy: Dosing and Long-Term Management.
Boster, Aaron L; Adair, Roy L; Gooch, Judith L; Nelson, Mary Elizabeth S; Toomer, Andrea; Urquidez, Joe; Saulino, Michael
2016-08-01
Intrathecal baclofen (ITB) therapy aims to reduce spasticity and provide functional control. An expert panel consulted on best practices. Pump fill and drug delivery can be started intraoperatively, with monitoring for at least eight hours. Initiate with the 500 mcg/mL concentration. The starting daily dose should be twice the effective bolus screening dose, or the screening dose if the patient had a prolonged response (greater than eight hours) or negative reactions. Oral antispasmodics can be weaned, one drug at a time beginning with oral baclofen after ITB begins. Assessment should occur within 24 hours of a dose change. For adults, daily dose increases may be 5% to 15% once every 24 hours for cerebral-origin spasticity and 10% to 30% once every 24 hours for spinal-origin spasticity. Daily dose increases can be 5% to 15% once every 24 hours for children. Inpatients should be assessed at least every 24 hours and receive rehabilitation. Step dosing can be used for outpatients who cannot return daily. Dosing options include simple continuous dosing, variable 24-hour flex dosing, or regularly scheduled boluses. Patients/caregivers should understand the care plan, responsibilities, and possible side-effects. Low-reservoir alarm dates and refill schedules should be written down, along with emergency contact information. A higher concentration at refill can extend refill intervals, and a bridge bolus must be programmed. Time changes may affect flex dosing. Pump replacement should be scheduled at least three months in advance. ITB dosing is multistep and individualized. © 2016 International Neuromodulation Society.
DOT National Transportation Integrated Search
2013-12-01
This study is a supplement to a previous study of bridge washing practices that focused on steel : superstructures. This study examined the perceived costs and benefits of routine washing of both : steel and concrete bridges, with emphasis on substru...
Implementation of sustainable and green design and construction practices for bridges.
DOT National Transportation Integrated Search
2012-12-01
The focus of this research is to develop a framework for more sustainable design and construction : processes for new bridges, and sustainable maintenance practices for existing bridges. The framework : includes a green rating system for bridges. The...
ERIC Educational Resources Information Center
Szteinberg, Gabriela; Balicki, Scott; Banks, Gregory; Clinchot, Michael; Cullipher, Steven; Huie, Robert; Lambertz, Jennifer; Lewis, Rebecca; Ngai, Courtney; Weinrich, Melissa; Talanquer, Vicente; Sevian, Hannah
2014-01-01
Professional development that bridges gaps between educational research and practice is needed. However, bridging gaps can be difficult because teachers and educational researchers often belong to different Communities of Practice, as their activities, goals, and means of achieving those goals often differ. Meaningful collaboration among teachers…
Verhagen, Evert; Voogt, Nelly; Bruinsma, Anja; Finch, Caroline F
2014-04-01
Evidence of effectiveness does not equal successful implementation. To progress the field, practical tools are needed to bridge the gap between research and practice and to truly unite effectiveness and implementation evidence. This paper describes the Knowledge Transfer Scheme integrating existing implementation research frameworks into a tool which has been developed specifically to bridge the gap between knowledge derived from research on the one side and evidence-based usable information and tools for practice on the other.
Virtual Communities of Practice: Bridging Research and Practice Using Web 2.0
ERIC Educational Resources Information Center
Lewis, Laura A.; Koston, Zoe; Quartley, Marjorie; Adsit, Jason
2011-01-01
A significant dilemma for the health and human service professions continues to be the question of how best to bridge the divide between academic research and practice. Communities of practice have traditionally been a vehicle for collaborative research and for information exchange (Moore, 2008). Through collaboration, communities of practice have…
DOT National Transportation Integrated Search
2013-04-01
The US Highway 6 Bridge over Keg Creek outside of Council Bluffs, Iowa is a demonstration bridge site chosen to put into practice : newly-developed Accelerated Bridge Construction (ABC) concepts. One of these new concepts is the use of prefabricated ...
Online Book Clubs: Bridges between Old and New Literacies Practices
ERIC Educational Resources Information Center
Scharber, Cassandra
2009-01-01
In this Digital Literacies column, online book clubs are offered as one example of how to effectively bridge old and new literacy practices. These Internet-based book clubs capitalize on children's interest in new literacy practices while complementing, and hopefully encouraging, traditional reading practices. Examples from online book clubs…
Highway bridge inspection : state-of-the-practice survey
DOT National Transportation Integrated Search
2001-04-01
The congressionally mandated National Bridge Inspection program requires States to periodically inventory, inspect, and rate all highway bridges on public roads. The National Bridge Inspection Standards, implemented in 1971, prescribe minimum require...
Sandhåland, Hilde; Oltedal, Helle A; Hystad, Sigurd W; Eid, Jarle
2015-06-01
This study provides empirical data about shipboard practices in bridge operations on board a selection of platform supply vessels (PSVs). Using the theoretical concept of distributed situation awareness, the study examines how situation awareness (SA)-related information is distributed and coordinated at the bridge. This study thus favours a systems approach to studying SA, viewing it not as a phenomenon that solely happens in each individual's mind but rather as something that happens between individuals and the tools that they use in a collaborative system. Thus, this study adds to our understanding of SA as a distributed phenomenon. Data were collected in four field studies that lasted between 8 and 14 days on PSVs that operate on the Norwegian continental shelf and UK continental shelf. The study revealed pronounced variations in shipboard practices regarding how the bridge team attended to operational planning, communication procedures, and distracting/interrupting factors during operations. These findings shed new light on how SA might decrease in bridge teams during platform supply operations. The findings from this study emphasize the need to assess and establish shipboard practices that support the bridge teams' SA needs in day-to-day operations. Provides insights into how shipboard practices that are relevant to planning, communication and the occurrence of distracting/interrupting factors are realized in bridge operations.Notes possible areas for improvement to enhance distributed SA in bridge operations.
Brownson, Ross C; Fielding, Jonathan E; Green, Lawrence W
2018-04-01
Timely implementation of principles of evidence-based public health (EBPH) is critical for bridging the gap between discovery of new knowledge and its application. Public health organizations need sufficient capacity (the availability of resources, structures, and workforce to plan, deliver, and evaluate the preventive dose of an evidence-based intervention) to move science to practice. We review principles of EBPH, the importance of capacity building to advance evidence-based approaches, promising approaches for capacity building, and future areas for research and practice. Although there is general agreement among practitioners and scientists on the importance of EBPH, there is less clarity on the definition of evidence, how to find it, and how, when, and where to use it. Capacity for EBPH is needed among both individuals and organizations. Capacity can be strengthened via training, use of tools, technical assistance, assessment and feedback, peer networking, and incentives. Modest investments in EBPH capacity building will foster more effective public health practice.
Design of piles for integral abutment bridges.
DOT National Transportation Integrated Search
1984-08-01
More and more, integral abutment bridges are being used in place : of the more traditional bridge designs with expansion releases. In : this study, states which use integral abutment bridges were surveyed : to determine their current practice in the ...
Sandhåland, Hilde; Oltedal, Helle A; Hystad, Sigurd W; Eid, Jarle
2015-01-01
This study provides empirical data about shipboard practices in bridge operations on board a selection of platform supply vessels (PSVs). Using the theoretical concept of distributed situation awareness, the study examines how situation awareness (SA)-related information is distributed and coordinated at the bridge. This study thus favours a systems approach to studying SA, viewing it not as a phenomenon that solely happens in each individual's mind but rather as something that happens between individuals and the tools that they use in a collaborative system. Thus, this study adds to our understanding of SA as a distributed phenomenon. Data were collected in four field studies that lasted between 8 and 14 days on PSVs that operate on the Norwegian continental shelf and UK continental shelf. The study revealed pronounced variations in shipboard practices regarding how the bridge team attended to operational planning, communication procedures, and distracting/interrupting factors during operations. These findings shed new light on how SA might decrease in bridge teams during platform supply operations. The findings from this study emphasize the need to assess and establish shipboard practices that support the bridge teams' SA needs in day-to-day operations. Practitioner points Provides insights into how shipboard practices that are relevant to planning, communication and the occurrence of distracting/interrupting factors are realized in bridge operations. Notes possible areas for improvement to enhance distributed SA in bridge operations. PMID:26028823
Implementation of sustainability in bridge design, construction and maintenance.
DOT National Transportation Integrated Search
2012-12-01
The focus of this research is to develop a framework for more sustainable design and construction : processes for new bridges, and sustainable maintenance practices for existing bridges. The framework : includes a green rating system for bridges. The...
The effect of bridge deck design methodology on crack control.
DOT National Transportation Integrated Search
2010-01-30
At present, the Idaho Transportation Department (ITD) Bridge Design Manual allows engineers to use the AASHTO empirical method to : design concrete bridge decks. However, the ITD Bridge Section would like to compare their design practices to those em...
Computational Fluid Dynamic Analysis of Hydrodynamic forces on inundated bridge decks
NASA Astrophysics Data System (ADS)
Afzal, Bushra; Guo, Junke; Kerenyi, Kornel
2010-11-01
The hydraulic forces experienced by an inundated bridge deck have great importance in the design of bridges. Flood flows or hurricane add significant hydrodynamic loading on bridges, possibly resulting in failure of the bridge superstructures. The objective of the study is to establish validated computational practice to address research needs of the transportation community via computational fluid dynamic simulations. The reduced scale experiments conducted at Turner-Fairbank Highway Research Center establish the foundations of validated computational practices to address the research needs of the transportation community. Three bridge deck prototypes were used: a typical six-girder highway bridge deck, a three-girder deck, and a streamlined deck designed to better withstand the hydraulic forces. Results of the study showed that the streamlined deck significantly reduces drag, lift, and moment coefficient in comparison to the other bridge deck types. The CFD results matched the experimental data in terms of the relationship between inundation ratio and force measured at the bridge. The results of the present research will provide a tool for designing new bridges and retrofitting old ones.
ERIC Educational Resources Information Center
Rubin, Allen
2015-01-01
This keynote address discusses previous and ongoing efforts to reduce the persistent gap between research and practice in social work and offers recommendations for further bridging that gap. Key among those recommendations is the need to conduct descriptive outcome studies of efforts to adapt research-supported interventions in everyday practice…
Evidence-Based Practice in Autism Educational Research: Can We Bridge the Research and Practice Gap?
ERIC Educational Resources Information Center
Guldberg, Karen
2017-01-01
In order to develop deeper and better understandings of what constitutes effective educational practices, and to bridge the gap between research and practice, there is a need for a paradigm shift in autism educational research. The contribution of this paper is to examine the key methodological challenges that stand in the way of autism…
Five-year clinical evaluation of zirconia-based bridges in patients in UK general dental practices.
Burke, F J T; Crisp, R J; Cowan, A J; Lamb, J; Thompson, O; Tulloch, N
2013-11-01
This study reported the results at 5 years of fixed-fixed all-ceramic bridges, constructed in a yttria oxide stabilized tetragonal zirconium oxide polycrystal (Y-TZP) substructure, placed in adult patients in UK general dental practices. Four UK general dental practitioners recruited patients who required fixed bridgework and, after obtaining informed written consent, appropriate clinical and radiographic assessments were completed. The teeth were prepared and bridges constructed in accordance with the manufacturer's instructions. Each bridge was reviewed annually within 3 months of the anniversary of its placement by a calibrated examiner, together with the clinician who had placed the restoration, using modified USPHS criteria. Of the 41 bridges originally placed, 33 bridges were examined at 5 years. All Y-TZP frameworks were intact and no bridge retainers had debonded. Eight chipping fractures in the veneering ceramic were noted over the 5-year period. In five cases the patients were unaware of these and these cases were polished. Of the remaining three cases, in one a repair was attempted but was unsuccessful, but the bridge remained in satisfactory service. However, in the case involving a chipping fracture of the mesial-incisal angle of a central incisor, it was considered that replacement of the bridge was necessary. 97% (n=32) of the 33 Lava Y-TZP fixed-fixed bridges, evaluated in patients attending UK general dental practices, were found to be performing satisfactorily. The use of Y-TZP frameworks holds promise. Copyright © 2013 Elsevier Ltd. All rights reserved.
DOT National Transportation Integrated Search
2013-09-01
The mission of Rutgers Universitys Center for Advanced Infrastructure and Transportation (CAIT) Bridge Resource Program : (BRP) is to provide bridge engineering support to the New Jersey Department of Transportation (NJDOT)s Bridge : Engineerin...
Development of a precast bridge deck overhang system for the rock creek bridge.
DOT National Transportation Integrated Search
2008-12-01
Precast, prestressed panels are commonly used at interior beams for bridges in Texas. The use of these : panels provides ease of construction, sufficient capacity, and good economy for the construction of : bridges in Texas. Current practice for the ...
Remote bridge scour monitoring : a prioritization and implementation guideline
DOT National Transportation Integrated Search
1999-05-01
Having the largest bridge population in the nation, the state of Texas stands to gain much through the development of bridge scour-monitoring and evaluation practices. Because it has such a large bridge population to manage, the Texas Department of T...
Neutron Exposures in Human Cells: Bystander Effect and Relative Biological Effectiveness
Seth, Isheeta; Schwartz, Jeffrey L.; Stewart, Robert D.; Emery, Robert; Joiner, Michael C.; Tucker, James D.
2014-01-01
Bystander effects have been observed repeatedly in mammalian cells following photon and alpha particle irradiation. However, few studies have been performed to investigate bystander effects arising from neutron irradiation. Here we asked whether neutrons also induce a bystander effect in two normal human lymphoblastoid cell lines. These cells were exposed to fast neutrons produced by targeting a near-monoenergetic 50.5 MeV proton beam at a Be target (17 MeV average neutron energy), and irradiated-cell conditioned media (ICCM) was transferred to unirradiated cells. The cytokinesis-block micronucleus assay was used to quantify genetic damage in radiation-naïve cells exposed to ICCM from cultures that received 0 (control), 0.5, 1, 1.5, 2, 3 or 4 Gy neutrons. Cells grown in ICCM from irradiated cells showed no significant increase in the frequencies of micronuclei or nucleoplasmic bridges compared to cells grown in ICCM from sham irradiated cells for either cell line. However, the neutron beam has a photon dose-contamination of 5%, which may modulate a neutron-induced bystander effect. To determine whether these low doses of contaminating photons can induce a bystander effect, cells were irradiated with cobalt-60 at doses equivalent to the percent contamination for each neutron dose. No significant increase in the frequencies of micronuclei or bridges was observed at these doses of photons for either cell line when cultured in ICCM. As expected, high doses of photons induced a clear bystander effect in both cell lines for micronuclei and bridges (p<0.0001). These data indicate that neutrons do not induce a bystander effect in these cells. Finally, neutrons had a relative biological effectiveness of 2.0±0.13 for micronuclei and 5.8±2.9 for bridges compared to cobalt-60. These results may be relevant to radiation therapy with fast neutrons and for regulatory agencies setting standards for neutron radiation protection and safety. PMID:24896095
Neutron exposures in human cells: bystander effect and relative biological effectiveness.
Seth, Isheeta; Schwartz, Jeffrey L; Stewart, Robert D; Emery, Robert; Joiner, Michael C; Tucker, James D
2014-01-01
Bystander effects have been observed repeatedly in mammalian cells following photon and alpha particle irradiation. However, few studies have been performed to investigate bystander effects arising from neutron irradiation. Here we asked whether neutrons also induce a bystander effect in two normal human lymphoblastoid cell lines. These cells were exposed to fast neutrons produced by targeting a near-monoenergetic 50.5 MeV proton beam at a Be target (17 MeV average neutron energy), and irradiated-cell conditioned media (ICCM) was transferred to unirradiated cells. The cytokinesis-block micronucleus assay was used to quantify genetic damage in radiation-naïve cells exposed to ICCM from cultures that received 0 (control), 0.5, 1, 1.5, 2, 3 or 4 Gy neutrons. Cells grown in ICCM from irradiated cells showed no significant increase in the frequencies of micronuclei or nucleoplasmic bridges compared to cells grown in ICCM from sham irradiated cells for either cell line. However, the neutron beam has a photon dose-contamination of 5%, which may modulate a neutron-induced bystander effect. To determine whether these low doses of contaminating photons can induce a bystander effect, cells were irradiated with cobalt-60 at doses equivalent to the percent contamination for each neutron dose. No significant increase in the frequencies of micronuclei or bridges was observed at these doses of photons for either cell line when cultured in ICCM. As expected, high doses of photons induced a clear bystander effect in both cell lines for micronuclei and bridges (p<0.0001). These data indicate that neutrons do not induce a bystander effect in these cells. Finally, neutrons had a relative biological effectiveness of 2.0 ± 0.13 for micronuclei and 5.8 ± 2.9 for bridges compared to cobalt-60. These results may be relevant to radiation therapy with fast neutrons and for regulatory agencies setting standards for neutron radiation protection and safety.
Bridging Theory and Practice in Norwegian Teacher Education through Action Research
ERIC Educational Resources Information Center
Husebo, Dag
2012-01-01
Handling the relationship between theory and practice is seemingly an endless challenge in Norwegian teacher education, and bridging theory and practice is highlighted whenever discussions about improvement of teacher education are raised. This article contributes to this discussion by shedding new light on the relationship through an analysis of…
Nations, Kari R; Bursi, Roberta; Dogterom, Peter; Ereshefsky, Larry; Gertsik, Lev; Mant, Tim; Schipper, Jacques
2012-09-01
A key challenge to dose selection in early central nervous system (CNS) clinical drug development is that patient tolerability profiles often differ from those of healthy volunteers (HVs), yet HVs are the modal population for determining doses to be investigated in phase II trials. Without clear tolerability data from the target patient population, first efficacy trials may include doses that are either too high or too low, creating undue risk for study participants and the development program overall. Bridging trials address this challenge by carefully investigating safety and tolerability in the target population prior to full-scale proof-of-concept trials. Org 26576 is an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor positive allosteric modulator that acts by modulating ionotropic AMPA-type glutamate receptors to enhance glutamatergic neurotransmission. In preparation for phase II efficacy trials in major depressive disorder (MDD), two separate phase I trials were conducted to evaluate safety, tolerability, and pharmacokinetics in HVs and in the target patient population. Both trials were randomized and placebo controlled, and included multiple rising-dose cohorts (HV range 100-400 mg bid; MDD range 100-600 mg bid). HVs (n = 36) and patients with MDD (n = 54) were dosed under similarly controlled conditions in an inpatient facility, HVs for up to 14 days and MDD patients for up to 28 days. Safety, tolerability, and pharmacokinetics were assessed frequently. Despite comparable pharmacokinetic profiles, the maximum tolerated dose (MTD) in depressed patients was 450 mg bid, twice the MTD established in HVs. No clinically relevant safety issues associated with Org 26576 were noted. This article presents safety, tolerability, and pharmacokinetic data from two different populations examined under similar dosing conditions. The important implications of such bridging work in phase II dose selection are discussed, as are study design and data interpretation challenges.
Petit, Caroline; Samson, Adeline; Morita, Satoshi; Ursino, Moreno; Guedj, Jérémie; Jullien, Vincent; Comets, Emmanuelle; Zohar, Sarah
2018-06-01
The number of trials conducted and the number of patients per trial are typically small in paediatric clinical studies. This is due to ethical constraints and the complexity of the medical process for treating children. While incorporating prior knowledge from adults may be extremely valuable, this must be done carefully. In this paper, we propose a unified method for designing and analysing dose-finding trials in paediatrics, while bridging information from adults. The dose-range is calculated under three extrapolation options, linear, allometry and maturation adjustment, using adult pharmacokinetic data. To do this, it is assumed that target exposures are the same in both populations. The working model and prior distribution parameters of the dose-toxicity and dose-efficacy relationships are obtained using early-phase adult toxicity and efficacy data at several dose levels. Priors are integrated into the dose-finding process through Bayesian model selection or adaptive priors. This calibrates the model to adjust for misspecification, if the adult and pediatric data are very different. We performed a simulation study which indicates that incorporating prior adult information in this way may improve dose selection in children.
Developing Student Assessment Related to a Workplacement: A Bridge between Practice and Improvement
ERIC Educational Resources Information Center
Vuoskoski, Pirjo; Poikela, Sari
2015-01-01
This paper explores the ways in which student assessment can be developed in higher education and work-related contexts to form a strong bridge between practice and improvement. Our aim is to provide a starting point for evaluation and improvement of assessment practices, which benefits the learners, instructors, and designers of the curricula, as…
Sreenivas Alampalli; Sheila Rimal Duwadi; Reagan Sentelle Herman; Danielle D. Kleinhans; Khaled Mahmoud; James C. Ray; James P. Wacker; Nur Yazdani
2008-01-01
The participants to the workshop were given the charge to discuss (1) bridge design issues including best practices in design and detailing that could be used to improve durability, extend service life and prevent premature deterioration, (2) performance measures needed to better determine bridge condition, (3) technologies that could be used to monitor bridge life and...
FHWA LTBP Bridge Performance Primer
DOT National Transportation Integrated Search
2014-02-01
This TechBrief defines bridge performance and discusses the importance of measuring performance and current practices for doing so. It identifies key issues to improving performance measures and the role the Long-Term Bridge Performance (LTBP) Progra...
Implementation guidance for accelerated bridge construction in South Dakota
DOT National Transportation Integrated Search
2017-09-01
A study was conducted to investigate implementation of accelerated bridge construction (ABC) in South Dakota. Accelerated bridge construction is defined as construction practices that employ innovative techniques to reduce on-site construction time a...
Bridging the Theory-to-Practice Gap: Some Thoughts from an Internal OD Consultant
ERIC Educational Resources Information Center
Myers, Nancy F.
2008-01-01
In this article, the author shares her thoughts on bridging the theory-to-practice gap in human resource development (HRD). She says both theorists and practitioners are responsible for the gap between theory and practice. They need to open up their respective cultures to each other and invite one another to participate. They have to discard…
ERIC Educational Resources Information Center
Bennett, Troy
2016-01-01
Academic researchers dedicated to contributing to quality improvement in professional practice need to find more effective ways to bridge the gap between research and practice. Bridging the gap requires understanding what encourages the use of research findings by practitioners and what discourages it, as well as understanding how practitioners…
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Work practice standards for conducting lead-based paint activities: public and commercial buildings, bridges and superstructures. [Reserved... and commercial buildings, bridges and superstructures. [Reserved] ...
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Work practice standards for conducting lead-based paint activities: public and commercial buildings, bridges and superstructures. [Reserved... and commercial buildings, bridges and superstructures. [Reserved] ...
Terrestrial laser scanning-based bridge structural condition assessment : InTrans project reports.
DOT National Transportation Integrated Search
2016-05-01
Objective, accurate, and fast assessment of a bridges structural condition is critical to the timely assessment of safety risks. : Current practices for bridge condition assessment rely on visual observations and manual interpretation of reports a...
Development of a precast bridge deck overhang system
DOT National Transportation Integrated Search
2011-02-01
Prestressed-precast panels are commonly used at interior beams for bridge decks in Texas. The use of these panels can provide ease : of construction, sufficient capacity, and good economy for the construction of bridge decks in Texas. Current practic...
Theory Development: A Bridge between Practice and Research
ERIC Educational Resources Information Center
Southern, Stephen; Devlin, James
2010-01-01
Theory development is an intentional process by which marriage and family counselors may bridge the gap between research and practice. The theory building process includes inductive and deductive forms of reasoning, qualitative and quantitative approaches to knowledge development, and diffusion of innovations. Grounded theory provides an…
ERIC Educational Resources Information Center
Seale, Jane K.
2006-01-01
This paper explores the extent to which existing accessibility metaphors can help to develop our conceptualizations of accessible e-learning practice in higher education and outlines a proposal for a new rainbow bridge metaphor for accessible e-learning practice. The need for a metaphor that reflects in more depth what we are beginning to…
Building Bridges One Line at a Time
ERIC Educational Resources Information Center
Grigsby, Cathy Murray
2012-01-01
In this article, first-grade students were taught the different kinds of lines that were part of the construction of various bridges--the curved lines of the arches of stone bridges, straight lines connecting the cables of a suspension bridge, vertical lines, horizontal lines, and so on. They gained practice in drawing structures and in fine brush…
Bridging the Scholar-Practitioner Gap: The San Antonio Export Leaders Program
ERIC Educational Resources Information Center
Jackson, Sara C.
2013-01-01
Bridging the gap between theory and practice enables trade service providers to effectively reach the small business community interested in entering foreign markets. This paper describes how the award-winning San Antonio Export Leaders program is a model for applying theoretical concepts to the practice of international business.
Functional relations and cognitive psychology: Lessons from human performance and animal research.
Proctor, Robert W; Urcuioli, Peter J
2016-02-01
We consider requirements for effective interdisciplinary communication and explore alternative interpretations of "building bridges between functional and cognitive psychology." If the bridges are intended to connect radical behaviourism and cognitive psychology, or functional contextualism and cognitive psychology, the efforts are unlikely to be successful. But if the bridges are intended to connect functional relationships and cognitive theory, no construction is needed because the bridges already exist within cognitive psychology. We use human performance and animal research to illustrate the latter point and to counter the claim that the functional approach is unique in offering a close relationship between science and practice. Effective communication will be enhanced and, indeed, may only occur if the goal of functional contextualism extends beyond just "the advancement of functional contextual cognitive and behavioral science and practice" to "the advancement of cognitive and behavioral science and practice" without restriction. © 2015 International Union of Psychological Science.
DOT National Transportation Integrated Search
2011-09-01
Many U.S. bridges were built during the 1960s. Evaluating the structural condition of these bridges under todays traffic loads and safety expectations is difficult. This project is developing a practical program for structural health monitoring of...
Environmental, mechanical and life-cycle cost analysis of bridge columns.
DOT National Transportation Integrated Search
2014-08-01
Corrosion of RC bridge element is one of the major deterioration distresses in US Highway Bridges. FRP composites jackets can be : the economic and effective corrosion repair in future, though its practices and field installation as a means of corros...
23 CFR 650.809 - Movable span bridges.
Code of Federal Regulations, 2012 CFR
2012-04-01
... FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES... shall be selected wherever practicable. If there are social, economic, environmental or engineering reasons which favor the selection of a movable bridge, a cost benefit analysis to support the need for the...
23 CFR 650.809 - Movable span bridges.
Code of Federal Regulations, 2014 CFR
2014-04-01
... FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES... shall be selected wherever practicable. If there are social, economic, environmental or engineering reasons which favor the selection of a movable bridge, a cost benefit analysis to support the need for the...
23 CFR 650.809 - Movable span bridges.
Code of Federal Regulations, 2013 CFR
2013-04-01
... FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES... shall be selected wherever practicable. If there are social, economic, environmental or engineering reasons which favor the selection of a movable bridge, a cost benefit analysis to support the need for the...
Bridge maintenance program for the City of Columbia, Missouri : tech transfer summary.
DOT National Transportation Integrated Search
2017-09-01
The primary goal of this research was to extend the service lives of bridges in Columbia, Missouri. The overarching objective of the project was to develop bridge maintenance and preservation guidelines that focus on practical and implementable techn...
Bridge maintenance Program for the City of Columbia, Missouri : final report.
DOT National Transportation Integrated Search
2017-09-22
The goal of this project was to extend the service lives of bridges located in Columbia, Missouri. The objective of the project was to develop guidelines for bridge maintenance and preservation. The guidelines developed are focused on practical and i...
Species Identification and Design Value Estimation of Wooden Members in Covered Bridges
Alex C. Wiedenhoeft; David E. Kretschmann
2014-01-01
Covered timber bridges are historic structures with unique aesthetic value. To preserve this value and maintain bridges in service, robust evaluation of their performance and safety is necessary. The strength of the timber found in covered bridges can vary considerably, not only because of age and condition, but also because of species and grade. For the practicing...
Learning Bridge: Curricular Integration of Didactic and Experiential Education
Arendt, Cassandra S.; Cawley, Pauline; Buhler, Amber V.; Elbarbry, Fawzy; Roberts, Sigrid C.
2010-01-01
Objectives To assess the impact of a program to integrate introductory pharmacy practice experiences with pharmaceutical science topics by promoting active learning, self-directed learning skills, and critical-thinking skills. Design The Learning Bridge, a curriculum program, was created to better integrate the material first-year (P1) students learned in pharmaceutical science courses into their introductory pharmacy practice experiences. Four Learning Bridge assignments required students to interact with their preceptors and answer questions relating to the pharmaceutical science material concurrently covered in their didactic courses. Assessment Surveys of students and preceptors were conducted to measure the effectiveness of the Learning Bridge process. Feedback indicated the Learning Bridge promoted students' interaction with their preceptors as well as development of active learning, self-directed learning, and critical-thinking skills. Students also indicated that the Learning Bridge assignments increased their learning, knowledge of drug information, and comprehension of relevant data in package inserts. Conclusion The Learning Bridge process integrated the didactic and experiential components of the curriculum, enhancing student learning in both areas, and offered students educational opportunities to interact more with their preceptors. PMID:20498741
Serviceability-related issues for bridge live load deflection and construction closure pours.
DOT National Transportation Integrated Search
2015-06-01
This study investigated the design criteria and practices in an effort to improve the quality of bridge designs in the : State of Maryland and beyond. This first criterion investigated was the live load deflection for steel bridges. The : second desi...
DOT National Transportation Integrated Search
2015-08-01
Many older reinforced concrete deck girder (RCDG) bridges contain straight-bar terminations of flexural reinforcement in : flexural tension zones without special detailing. Common bridge design practice of the 1950s did not consider the additional : ...
DOT National Transportation Integrated Search
2009-11-01
Current practice with regard to designing bridge structures to resist impact loads associated with barge collisions relies upon the : use of the American Association of State Highway and Transportation Officials (AASHTO) bridge design specifications....
Collective Genius: Bridging the Gaps among Research, Innovation and Practice
ERIC Educational Resources Information Center
O'Hair, Mary John
2011-01-01
In this article, the author focuses on bridging the gaps among research, innovation, and practice. First, the author reflects on historical perspectives involving the use of research to improve education and serve the public good. Second, the author explores the current climate as reflected by three national reports highlighting future roles of…
Bridging the Gap between Research and Practice: Voice of Mediators
ERIC Educational Resources Information Center
Mehrani, Mehdi B.
2014-01-01
The present study aimed to explore the strategies that could be potentially employed in the Iranian ELT context to bridge the gap between research and practice. Data were collected through conducting a "focus group discussion" with a number of practitioner-researchers. The findings showed that to improve the relationship between…
International Higher Education's Scholar-Practitioners: Bridging Research and Practice
ERIC Educational Resources Information Center
Streitwieser, Bernhard, Ed.; Ogden, Anthony, Ed.
2016-01-01
The idea of the professional who bridges both research and practice has been largely overlooked and at times even disregarded by the academic and administrative structures that govern activity in higher education today. In international higher education, the number of students who now engage in mobility and exchange has expanded globally, along…
ERIC Educational Resources Information Center
Howe, Edward R.
2014-01-01
This narrative paper investigates a number of enduring and emerging themes reflecting teacher education in Canada over the past 40 years, including changes in information and communication technology, bridging gaps in theory and practice, English as a second language, French immersion and multicultural teacher development. Canadian teacher…
ERIC Educational Resources Information Center
Epstein, Irwin
2015-01-01
Challenging the "bridge metaphor" theme of this conference, this article contends that current practice-research integration strategies are more like research-to-practice "pipelines." The purpose of this article is to demonstrate the potential of clinical data-mining studies conducted by practitioners, practitioner-oriented PhD…
Innovative Contextualized Curriculum for a CNA to LPN Bridge Course. Promising Practice
ERIC Educational Resources Information Center
Office of Community College Research and Leadership, 2010
2010-01-01
As a pilot site selected to participate in Illinois' Shifting Gears (SG) initiative in 2007, Oakton Community College (OCC) partnered with Presbyterian Homes to develop a bridge course to prepare a cadre of their employed Certified Nursing Assistants (CNAs) to enter college-credit prerequisite courses to a Practical Nursing program. Oakton…
Bridge rail and approach railing for low-volume roads in Iowa : tech transfer summary, March 2010.
DOT National Transportation Integrated Search
2010-03-01
The primary objective of the research summarized below was to describe the state of the practice regarding the nations bridge rails and approach guardrails and to perform a statewide crash analysis involving bridge rails and approach guardrails on...
Load Distribution Factors for Composite Multicell Box Girder Bridges
NASA Astrophysics Data System (ADS)
Tiwari, Sanjay; Bhargava, Pradeep
2017-12-01
Cellular steel section composite with a concrete deck is one of the most suitable superstructures in resisting torsional and warping effects induced by highway loading. This type of structure has inherently created new design problems for engineers in estimating its load distribution when subjected to moving vehicles. Indian Codes of Practice does not provide any specific guidelines for the design of straight composite concrete deck-steel multi-cell bridges. To meet the practical requirements arising during the design process, a simple design method is needed for straight composite multi-cell bridges in the form of load distribution factors for moment and shear. This work presents load distribution characteristics of straight composite multi-cell box girder bridges under IRC trains of loads.
Design and Evaluation of Scour for Bridges Using HEC-18 (Volume 3 of 3).
DOT National Transportation Integrated Search
2017-07-04
The overall objective of this research is the development of a new approach for evaluating bridge scour for New Jersey's bridges on non-tidal waterways. The study commenced with a web-based survey of scour practice within the U.S. and a literature re...
Design and Evaluation of Scour for Bridges Using HEC-18 (Volume 1 of 3).
DOT National Transportation Integrated Search
2017-07-04
The overall objective of this research is the development of a new approach for evaluating bridge scour for New Jersey's bridges on non-tidal waterways. The study commenced with a web-based survey of scour practice within the U.S. and a literature re...
M324 : investigation of closure pour elimination for phased construction of steel girder bridges.
DOT National Transportation Integrated Search
2014-10-01
Phased construction is a common practice used by State DOTs during the : replacement of a bridge. This method allows for the traffic flow to be maintained on half : of the bridge while a new deck is constructed on the other half. For steel girder bri...
Design and Evaluation of Scour for Bridges Using HEC-18 (Volume 2 of 3).
DOT National Transportation Integrated Search
2017-07-04
The overall objective of this research is the development of a new approach for evaluating bridge scour for New Jersey's bridges on non-tidal waterways. The study commenced with a web-based survey of scour practice within the U.S. and a literature re...
DOT National Transportation Integrated Search
2012-12-01
Current AASHTO provisions for load rating flat-slab concrete bridges use the equivalent strip : width method, which is regarded as overly conservative compared to more advanced analysis : methods and field live load testing. It has been shown that li...
Bridging Theory and Practice in an Applied Retail Track
ERIC Educational Resources Information Center
Lange, Fredrik; Rosengren, Sara; Colliander, Jonas; Hernant, Mikael; Liljedal, Karina T.
2018-01-01
In this article, we present an educational approach that bridges theory and practice: an applied retail track. The track has been co-created by faculty and 10 partnering retail companies and runs in parallel with traditional courses during a 3-year bachelor's degree program in retail management. The underlying pedagogical concept is to move retail…
Standard plans for southern pine bridges
P. D. Hilbrich Lee; M. A. Ritter; M. H. Triche
1995-01-01
The development of standardized timber bridge plans and specifications is a key element in improving design and construction practices. The bridge plans presented were developed as a cooperative effort between the USDA Forest Service, Forest Products Laboratory (FPL); the University of Alabama; and the Southern Pine Council and are the first step in developing...
ERIC Educational Resources Information Center
Sanzo, Karen L.; Myran, Steve; Clayton, Jennifer K.
2011-01-01
Purpose: The purpose of this paper is to provide a Year 1 account of a partnership between a university and rural school district focusing specifically on how the project has helped to bridge the theory to practice divide and strengthen university-district ties. Design/methodology/approach: A design-based research paradigm was utilized to…
ERIC Educational Resources Information Center
Stafford-Brizard, K. Brooke; Cantor, Pamela; Rose, L. Todd
2017-01-01
Mind, brain, and education is a field developed with two key purposes: (1) to accelerate the knowledge developed through research by using an interdisciplinary approach, and (2) to create a bridge to connect and apply this knowledge to educational practice. While great progress has been made with regard to the interdisciplinary efforts of mind,…
Bridging Theory and Practice in the Leadership Classroom: Intentional Emergence as a Modern Pedagogy
ERIC Educational Resources Information Center
Werner, Linnette; Hellstrom, David; Chung, Jessica; Kessenich, Katherine; Taylor, Leonard, Jr.; Capeder, Anna
2016-01-01
With leadership education expanding at an unprecedented rate, there is an acute need for an evidence-based leadership pedagogy that can bridge the gap between leadership theory and student practice both in the classroom and beyond its boundaries. This paper will give an overview of the Intentional Emergence Model as a way to teach leadership to…
Code of Federal Regulations, 2012 CFR
2012-10-01
... conduct regular evaluations of railroad bridge inspection and management practices. The objective of these... condition, and the stresses imposed in those members by the service loads. (c) The factors which were used... provided: (i) The condition of the bridge has not changed significantly; and (ii) The stresses resulting...
Implicit Knowledge of General Upper Secondary School in a Bridge-Building Project
ERIC Educational Resources Information Center
Rasmussen, Annette; Andreasen, Karen
2016-01-01
Bridge-building activities are practiced widely in the education systems of Europe. They are meant to bridge transitions between lower and upper secondary school and form a mandatory part of the youth guidance system in Denmark. By giving pupils the opportunity to experience the different educational context of upper secondary school,…
ERIC Educational Resources Information Center
Wright, Nicola
2013-01-01
This study describes the experiences of nurses and allied health professionals as first-time knowledge brokers, attempting to bridge the research-practice gap within health care. A qualitative study using in-depth interviews and documentary analysis was conducted. The data was analysed using a thematic analysis strategy. Participants were 17…
A statistical model of operational impacts on the framework of the bridge crane
NASA Astrophysics Data System (ADS)
Antsev, V. Yu; Tolokonnikov, A. S.; Gorynin, A. D.; Reutov, A. A.
2017-02-01
The technical regulations of the Customs Union demands implementation of the risk analysis of the bridge cranes operation at their design stage. The statistical model has been developed for performance of random calculations of risks, allowing us to model possible operational influences on the bridge crane metal structure in their various combination. The statistical model is practically actualized in the software product automated calculation of risks of failure occurrence of bridge cranes.
Kahle, Jason T; Highsmith, M Jason; Kenney, John; Ruth, Tim; Lunseth, Paul A; Ertl, Janos
2017-06-01
This literature review was undertaken to determine if commonly held views about the benefits of a bone bridge technique are supported by the literature. Four databases were searched for articles pertaining to surgical strategies specific to a bone bridge technique of the transtibial amputee. A total of 35 articles were identified as potential articles. Authors included methodology that was applied to separate topics. Following identification, articles were excluded if they were determined to be low quality evidence or not pertinent. Nine articles were identified to be pertinent to one of the topics: Perioperative Care, Acute Care, Subjective Analysis and Function. Two articles sorted into multiple topics. Two articles were sorted into the Perioperative Care topic, 4 articles sorted into the Acute Care topic, 2 articles into the Subjective Analysis topic and 5 articles into the Function topic. There are no high quality (level one or two) clinical trials reporting comparisons of the bone bridge technique to traditional methods. There is limited evidence supporting the clinical outcomes of the bone bridge technique. There is no agreement supporting or discouraging the perioperative and acute care aspects of the bone bridge technique. There is no evidence defining an interventional comparison of the bone bridge technique. Current level III evidence supports a bone bridge technique as an equivalent option to the non-bone bridge transtibial amputation technique. Formal level I and II clinical trials will need to be considered in the future to guide clinical practice. Clinical relevance Clinical Practice Guidelines are evidence based. This systematic literature review identifies the highest quality evidence to date which reports a consensus of outcomes agreeing bone bridge is as safe and effective as alternatives. The clinical relevance is understanding bone bridge could additionally provide a mechanistic advantage for the transtibial amputee.
Longer Lasting Bridge Deck Overlays
DOT National Transportation Integrated Search
2018-04-01
The objective of this report is to determine the most effective method for bridge deck overlay construction and repair by assessing current practices; examining new products and technologies; and reviewing NCHRP (National Cooperative Highway Research...
Wagner, Chad R.; Fitzgerald, Sharon A.; Sherrell, Roy D.; Harned, Douglas A.; Staub, Erik L.; Pointer, Brian H.; Wehmeyer, Loren L.
2011-01-01
In 2008, the North Carolina General Assembly passed House Bill 2436 that required the North Carolina Department of Transportation (NCDOT) to study the water-quality effects of bridges on receiving streams. In response, the NCDOT and the U.S. Geological Survey (USGS) collaborated on a study to provide information necessary to address the requirements of the Bill. To better understand the effects of stormwater runoff from bridges on receiving streams, the following tasks were performed: (1) characterize stormwater runoff quality and quantity from a representative selection of bridges in North Carolina; (2) measure stream water quality upstream from selected bridges to compare bridge deck stormwater concentrations and loads to stream constituent concentrations and loads; and (3) determine if the chemistry of bed sediments upstream and downstream from selected bridges differs substantially based on presence or absence of a best management practice for bridge runoff.
Best Practices for Construction and Repair of Bridge Approaches and Departures
DOT National Transportation Integrated Search
2018-03-01
Florida Department of Transportation (FDOT) has experienced frequent distresses in bridge approach/departure asphalt pavements in its highway system. Commonly observed distresses include alligator cracking and rutting, which reduce roadway smoothness...
This Bridge Called My Leadership: An Essay on Black Women as Bridge Leaders in Education
ERIC Educational Resources Information Center
Horsford, Sonya Douglass
2012-01-01
The purpose of this essay is to contextualize the existing research literature on leadership for diversity, equity, and social justice in education with "bridge leadership" as historically practiced by Black women leaders in the USA. Its primary aim is to demonstrate how the intersection of race and gender as experienced by the Black…
Final Environmental Assessment, Horse Creek Bridge Replacement
2010-10-01
Final Environmental Assessment Horse Creek Bridge Replacement 78th Civil Engineer Group...Final Environmental Assessment Horse Creek Bridge Replacement 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 FINDING OF NO SIGNIFICANT IMPACT (FONSI)/ FINDING OF NO PRACTICABLE ALTERNATIVE (FONP A) HORSE
Yoon, Seyeol; Lee, Jae W.; Lee, Doheon
2014-01-01
Biomarkers prognostic for colorectal cancer (CRC) would be highly desirable in clinical practice. Proteins that regulate bile acid (BA) homeostasis, by linking metabolic sensors and metabolic enzymes, also called bridge proteins, may be reliable prognostic biomarkers for CRC. Based on a devised metric, “bridgeness,” we identified bridge proteins involved in the regulation of BA homeostasis and identified their prognostic potentials. The expression patterns of these bridge proteins could distinguish between normal and diseased tissues, suggesting that these proteins are associated with CRC pathogenesis. Using a supervised classification system, we found that these bridge proteins were reproducibly prognostic, with high prognostic ability compared to other known markers. PMID:25259881
Systematic Review: Bridging the Gap in RPN-to-RN Transitions.
Suva, Grace; Sager, Shelley; Mina, Elaine Santa; Sinclair, Nancy; Lloyd, Monique; Bajnok, Irmajean; Xiao, Sarah
2015-07-01
To review the evidence examining the influences of successful education and professional role transition for registered practical nurses (RPNs) pursuing a baccalaureate degree in nursing (BScN) and registered nurse (RN) licensure through RPN-to-RN bridging programs. Systematic review of papers published between 1995 and 2014 that evaluated students' education and professional role transitions from RPN to RN. Thirty-nine papers were selected that observed or studied the change or transition in designation from RPN to RN, or its equivalent, through bridging programs and analyzed thematically according to Meleis, Sawyer, Im, Hilfinger Messias, and Schumacher's transition model. Personal, community, and social conditions related to preparation for entry, program enrolment, and postgraduate clinical integration influence successful education and professional role transitions for RPN-to-RN bridging students. Providing key transition supports may enhance the potential for successful student transition into and throughout a bridging program, but further research is necessary to enhance this understanding and to recommend best practices for optimizing students' success. The evidence from this review identifies facilitators and barriers to successful education and professional role transition for RPN-to-RN bridging students, and identifies important considerations for future research. © 2015 Sigma Theta Tau International.
Health Monitoring and Evaluation of Long-Span Bridges Based on Sensing and Data Analysis: A Survey
Zhou, Jianting; Li, Xiaogang; Xia, Runchuan; Yang, Jun; Zhang, Hong
2017-01-01
Aimed at the health monitoring and evaluation of bridges based on sensing technology, the monitoring contents of different structural types of long-span bridges were defined. Then, the definition, classification, selection principle, and installation requirements of the sensors were summarized. The concept was proposed that new adaptable long-life sensors could be developed by new theories and new effects. The principle and methods to select controlled sections and optimize the layout design of measuring points were illustrated. The functional requirements were elaborated on about the acquisition, transmission, processing, and management of sensing information. Some advanced concepts about the method of bridge safety evaluation were demonstrated and technology bottlenecks in the current safety evaluation were also put forward. Ultimately, combined with engineering practices, an application was carried out. The results showed that new, intelligent, and reliable sensor technology would be one of the main future development directions in the long-span bridge health monitoring and evaluation field. Also, it was imperative to optimize the design of the health monitoring system and realize its standardization. Moreover, it is a heavy responsibility to explore new thoughts and new concepts regarding practical bridge safety and evaluation technology. PMID:28300785
Bridging the research-practice gap: breaking new ground in health care.
Mulhall, A
2001-08-01
Many theorists have discussed the existence of a gap between nursing research and practice. Consequently much time and effort has been expended in trying to devise strategies to bridge this divide. This article explores what the research-practice gap is and discusses five important reasons for it. The issue is then raised as to whether or not there is a gap between evidence and practice, despite the existence of the gap between research and practice. This is explored in relation to the potential conflict between the 'know how' knowledge important in practice and the 'know that' knowledge important in academia. Finally, the concept of practitioner-centred research is described as one strategy that would effectively obliterate the research-practice gap as it is currently conceived.
Investigation of best practices for maintenance of concrete bridge railings.
DOT National Transportation Integrated Search
2015-01-01
Biodeterioration on concrete surfaces of vertical elements of bridges represents a serious challenge to : the highway infrastructure in Louisiana. This report aims to document the causes of biodeterioration of : concrete surfaces and to document curr...
On Building Bridges: Cultural Agnosia, HipHopEd, and Urban Education
ERIC Educational Resources Information Center
Emdin, Christopher
2017-01-01
In this article, the author describes a lens for engaging in research and practice in urban education rooted in deep cultural understandings of the concept of building bridges and the impact of cultural agnosia.
Improving Bridging from Informatics Practice to Theory.
Lehmann, C U; Gundlapalli, A V
2015-01-01
In 1962, Methods of Information in Medicine ( MIM ) began to publish papers on the methodology and scientific fundamentals of organizing, representing, and analyzing data, information, and knowledge in biomedicine and health care. Considered a companion journal, Applied Clinical Informatics ( ACI ) was launched in 2009 with a mission to establish a platform that allows sharing of knowledge between clinical medicine and health IT specialists as well as to bridge gaps between visionary design and successful and pragmatic deployment of clinical information systems. Both journals are official journals of the International Medical Informatics Association. As a follow-up to prior work, we set out to explore congruencies and interdependencies in publications of ACI and MIM. The objectives were to describe the major topics discussed in articles published in ACI in 2014 and to determine if there was evidence that theory in 2014 MIM publications was informed by practice described in ACI publications in any year. We also set out to describe lessons learned in the context of bridging informatics practice and theory and offer opinions on how ACI editorial policies could evolve to foster and improve such bridging. We conducted a retrospective observational study and reviewed all articles published in ACI during the calendar year 2014 (Volume 5) for their main theme, conclusions, and key words. We then reviewed the citations of all MIM papers from 2014 to determine if there were references to ACI articles from any year. Lessons learned in the context of bridging informatics practice and theory and opinions on ACI editorial policies were developed by consensus among the two authors. A total of 70 articles were published in ACI in 2014. Clinical decision support, clinical documentation, usability, Meaningful Use, health information exchange, patient portals, and clinical research informatics emerged as major themes. Only one MIM article from 2014 cited an ACI article. There are several lessons learned including the possibility that there may not be direct links between MIM theory and ACI practice articles. ACI editorial policies will continue to evolve to reflect the breadth and depth of the practice of clinical informatics and articles received for publication. Efforts to encourage bridging of informatics practice and theory may be considered by the ACI editors. The lack of direct links from informatics theory-based papers published in MIM in 2014 to papers published in ACI continues as was described for papers published during 2012 to 2013 in the two companion journals. Thus, there is little evidence that theory in MIM has been informed by practice in ACI.
Raff, Adam B.; Seiler, Theo G.; Apiou-Sbirlea, Gabriela
2017-01-01
The ‘Bridging medicine and biomedical technology’ special all-congress session took place for the first time at the OSA Biophotonics Congress: Optics in Life Sciences in 2017 (http://www.osa.org/enus/meetings/osa_meetings/optics_in_the_life_sciences/bridging_medicine_and_biomedical_technology_specia/). The purpose was to identify key challenges the biomedical scientists in academia have to overcome to translate their discoveries into clinical practice through robust collaborations with industry and discuss best practices to facilitate and accelerate the process. Our paper is intended to complement the session by providing a deeper insight into the concept behind the structure and the content we developed. PMID:29296473
ERIC Educational Resources Information Center
Wieczorek, Joseph A., Ed.
1993-01-01
Papers from the conference include the following: "Activites orales et motivation dans l'etude du vocabulaire d'une langue etrangere (Oral Activities and Motivation in the Study of Vocabulary in a Foreign Language)" (M. Guisset); "Bridging High School and College Classes through the Multicultural Approach: The Case of Francophone…
Applications of FRP-OFBG sensors on bridge cables
NASA Astrophysics Data System (ADS)
Zhou, Zhi; Zhang, Zhichun; Deng, Nianchun; Zhao, Xuefeng; Li, Dongsheng; Wang, Chuang; Ou, Jinping
2005-05-01
It is still a practical problem how to effectively install FBG sensors on bridge cabes. In this paper, a simple and effective solution is introduced to develop smart bridge cables using FRP-OFBG bars developed in HIT (Harbin Institute of Technology). Here, the FRP-OFBG bar acts as one component of the cable and shows force resistance and well-protected sensors in service. The installation techniques and the sensing properties of FBGs in three kinds of cables, FRP cables, common steel-wire cable and extruded-anchor cable, are introduced and tested under dead load. Moreover, the preliminary introduction of a practical field application based on this solution has been also given. The experimental results show that the deformability of FRP-OFBG bars in the smart cables can reach the terminal and show wonderful accuracy, which shows that such kind of smart cable is practical in field application.
Evaluation of damage in reinforced concrete bridge beams using acoustic emission technique
NASA Astrophysics Data System (ADS)
Vidya Sagar, R.; Raghu Prasad, B. K.; Sharma, Reema
2012-06-01
Acoustic emission (AE) testing is a well-known method for damage identification of various concrete structures including bridges. This article presents a method to assess damage in reinforced concrete (RC) bridge beams subjected to incremental cyclic loading. The specifications in the standard NDIS-2421 were used to classify the damage in RC bridge beams. Earlier researchers classified the damage occurring in bridge beams by using crack mouth opening displacement (CMOD) and AE released and proposed a standard (NDIS-2421: the Japanese Society for NonDestructive Inspection). In general, multiple cracks take place in RC beams under bending; therefore, utilisation of CMOD for crack detection may not be appropriate. In the present study, the damage in RC beams is classified by using the AE released, deflection, strains in steel and concrete, because the measurement of the strains in steel and concrete is easy and the codes of practice are specified for different limit states (IS-456:2000). The observations made in the present experimental study have some important practical applications in assessing the state of damage of concrete structural members.
DOT National Transportation Integrated Search
1995-11-01
This document is the third of HEC 18, i.e., presents the state of knowledge and practice for the design, : evaluation, and inspection of bridges for scour. It contains updated material not included in the second : edition dated April 1993. This docum...
Repair methods for prestressed girder bridges.
DOT National Transportation Integrated Search
2009-04-30
It is common practice that aging and structurally damaged prestressed concrete bridge members are taken out of service and replaced. : This, however, is not an efficient use of materials and resources since the member can often be repaired in situ. T...
Repair systems for deteriorated bridge piles : final report.
DOT National Transportation Integrated Search
2017-04-01
The objective of this research project is to develop a durable repair system for deteriorated steel bridge piles that : can be implemented without the need for dewatering. A rigorous survey of the relevant practice nationwide was : conducted to infor...
Multimedia package for LRFD concrete bridge design.
DOT National Transportation Integrated Search
2009-02-01
This Project developed a Load and Resistance Factor Design (LRFD) multimedia package to provide a practical introduction and an in-depth understanding of the technological advances in the design of concrete bridges. This package can be used to train ...
Niles, Sarah E; Balazs, George C; Cawley, Christina; Bosse, Michael; Mackenzie, Ellen; Li, Yaunzhang; Andersen, Romney C
2015-04-01
Orthopedic trauma remains one of the most survivable battlefield injuries seen in modern conflicts. Translating research into practice is a critical bridge that permits surgeons to further optimize medical outcomes. Orthopedic surgeons serving in the military may treat little to no trauma in their stateside practice. In conflict zones, however, the majority of their patients will have traumatic injuries. Determining risk factors for nonevidence-based practice can help identify provider knowledge gaps, which can then be targeted before deployment. Surveys were developed which sought to identify factors contributing to continued medical education and practice, as well as scenario-based questions on military-relevant orthopedic trauma. Analysis of 188 survey respondents revealed that providers with military service and less than 10 years of practice are optimally bridging research into military-relevant orthopedic trauma practice. Reprint & Copyright © 2015 Association of Military Surgeons of the U.S.
Boonstra, P S; Braun, T M; Taylor, J M G; Kidwell, K M; Bellile, E L; Daignault, S; Zhao, L; Griffith, K A; Lawrence, T S; Kalemkerian, G P; Schipper, M J
2017-07-01
Regulatory agencies and others have expressed concern about the uncritical use of dose expansion cohorts (DECs) in phase I oncology trials. Nonetheless, by several metrics-prevalence, size, and number-their popularity is increasing. Although early efficacy estimation in defined populations is a common primary endpoint of DECs, the types of designs best equipped to identify efficacy signals have not been established. We conducted a simulation study of six phase I design templates with multiple DECs: three dose-assignment/adjustment mechanisms multiplied by two analytic approaches for estimating efficacy after the trial is complete. We also investigated the effect of sample size and interim futility analysis on trial performance. Identifying populations in which the treatment is efficacious (true positives) and weeding out inefficacious treatment/populations (true negatives) are competing goals in these trials. Thus, we estimated true and false positive rates for each design. Adaptively updating the MTD during the DEC improved true positive rates by 8-43% compared with fixing the dose during the DEC phase while maintaining false positive rates. Inclusion of an interim futility analysis decreased the number of patients treated under inefficacious DECs without hurting performance. A substantial gain in efficiency is obtainable using a design template that statistically models toxicity and efficacy against dose level during expansion. Design choices for dose expansion should be motivated by and based upon expected performance. Similar to the common practice in single-arm phase II trials, cohort sample sizes should be justified with respect to their primary aim and include interim analyses to allow for early stopping. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
McKenna, Suzanne; Jones, Fiona; Glenfield, Pauline; Lennon, Sheila
2015-07-01
Enabling self-management behaviors is considered important in order to develop coping strategies and confidence for managing life with a long-term condition. However, there is limited research into stroke-specific self-management interventions. The aim of this randomized controlled trial was to evaluate the feasibility of delivering the Bridges stroke self-management program in addition to usual stroke rehabilitation compared with usual rehabilitation only. Participants recruited from the referrals to a community stroke team were randomly allocated to the Bridges stroke self-management program, receiving either one session of up to one-hour per week over a six-week period in addition to usual stroke rehabilitation, or usual rehabilitation only. Feasibility was measured using a range of methods to determine recruitment and retention; adherence to the program; suitability and variability of outcome measures used; application and fidelity of the program; and acceptability of the program to patients, carers and professionals. Twenty-five people were recruited to the study over a 13-month period. Eight out of the 12 participants in the Bridges stroke self-management program received all six sessions; there was one withdrawal from the study. There were changes in outcomes between the two groups. Participants who received the Bridges stroke self-management program appeared to have a greater change in self-efficacy, functional activity, social integration and quality of life over the six-week intervention period and showed less decline in mood and quality of life at the three-month follow-up. Professionals found the program acceptable to use in practice, and feedback from participants was broadly positive. The findings from this study appear promising, but questions remain regarding the feasibility of delivering the Bridges stroke self-management program in addition to usual rehabilitation. The dose response of receiving the program cannot be ruled out, and the next stage of research should explore the feasibility of an integrated program. Exploration of the reasons behind relatively low recruitment and of the sensitivity of outcome measures to detect a change are also required. Additional investigation of intervention fidelity is required to monitor if the program is being delivered as intended. © 2013 The Authors. International Journal of Stroke © 2013 World Stroke Organization.
Understanding and mitigating effects of chloride deicer exposure on concrete.
DOT National Transportation Integrated Search
2014-09-01
Field and laboratory investigations were conducted to examine the effects of chloride deicers on concrete : bridge decks and to identify and evaluate best practices and products to mitigate such effects. The concrete bridge decks : exposed to KAc or ...
Fellows, Patricia; Price, Jessica; Martin, Shannon; Metcalfe, Karen; Krile, Robert; Barnewall, Roy; Hart, Mary Kate; Lockman, Hank
2015-09-01
The efficacy of a recombinant plague vaccine (rF1V) was evaluated in cynomolgus macaques (CMs) to establish the relationship among vaccine doses, antibody titers, and survival following an aerosol challenge with a lethal dose of Yersinia pestis strain Colorado 92. CMs were vaccinated with a range of rF1V doses on a three-dose schedule (days 0, 56, and 121) to provide a range of survival outcomes. The humoral immune response following vaccination was evaluated with anti-rF1, anti-rV, and anti-rF1V bridge enzyme-linked immunosorbent assays (ELISAs). Animals were challenged via aerosol exposure on day 149. Vaccine doses and antibody responses were each significantly associated with the probability of CM survival (P < 0.0001). Vaccination also decreased signs of pneumonic plague in a dose-dependent manner. There were statistically significant correlations between the vaccine dose and the time to onset of fever (P < 0.0001), the time from onset of fever to death (P < 0.0001), the time to onset of elevated respiratory rate (P = 0.0003), and the time to onset of decreased activity (P = 0.0251) postinfection in animals exhibiting these clinical signs. Delays in the onset of these clinical signs of disease were associated with larger doses of rF1V. Immunization with ≥ 12 μg of rF1V resulted in 100% CM survival. Since both the vaccine dose and anti-rF1V antibody titers correlate with survival, rF1V bridge ELISA titers can be used as a correlate of protection. Copyright © 2015, American Society for Microbiology. All Rights Reserved.
1984-07-01
polysilicon gates. They have con- sistently demonstrated total dose tolerance in the l05 rad (Si) to 1 0b rad (Si) range. They have also demonstrated...FPGs. Because there are two full bridges for one direction of resonant current two SGRs uxust be fired for each bridge, :.:: oL total of tour for the...less than 0.5 W. 2.5.4.4 BLoc-k Diagram - Figure 2.5.4-6 is a block diagram ol thC three-phase unit. All of the input and output signals for the three
DOT National Transportation Integrated Search
2012-09-01
Mildew growth and darkening of concrete bridge railings and structures have : negative impacts on their aesthetic value and durability. Darkening and stains : are created by growth of biofi lms such as algae, cyanobacteria, and fungi. As : fungi grow...
DOT National Transportation Integrated Search
2015-08-01
Research is currently being conducted to improve bridge inspection practices. One potential : improvement is the use of nondestructive testing equipment to supplement visual inspection. To : consider the costs and benefits of this equipment, data abo...
Best management practices for storage of historic metal truss bridges.
DOT National Transportation Integrated Search
2014-07-01
As part of a 2002 agreement with the FHWA, GDOT has committed to consider storing metal truss : bridges of historic value in lieu of demolition, until a recipient could be located. This research addresses the most : effective processes for storage of...
Best practices for the rehabilitation and moving of historic metal truss bridges.
DOT National Transportation Integrated Search
2006-01-01
The Virginia Department of Transportation and the Department of Historic Resources are responsible for the management of about 30 historic truss bridges. All too often, these structures do not meet today's traffic demands or safety standards. Their g...
EBP partners: doctoral students and practicing clinicians bridging the theory-practice gap.
Peck, Sydney; Lester, Jennifer; Hinshaw, Ginger; Stiles, Anne; Dingman, Sharon K
2009-01-01
The theory-practice gap is one component of the barriers to implementing evidence-based practice. Texas Woman's University College of Nursing and Presbyterian Hospital of Denton joined forces to bridge this gap, allowing doctoral students to provide educational offerings to practicing nurses. Through a Graduate Assistance in Areas of National Need grant, doctoral students completed supervised teaching practicums at the hospital, assisting the hospital to implement evidence-based practice with the ultimate goal of applying for Magnet status. The hospital benefited from the addition of research expertise and mentoring for the staff members. The students benefited from the opportunities to teach and to share knowledge with these clinical experts. This program has been successful in meeting the needs of both parties. Recommendations are given for other institutions interested in establishing similar relationships.
Lilienfeld, Scott O; Ritschel, Lorie A; Lynn, Steven Jay; Brown, Amanda P; Cautin, Robin L; Latzman, Robert D
2013-07-01
The field of eating disorders (EDs) treatment has been beset by a marked disjunction between scientific evidence and clinical application. We describe the nature and scope of the research-practice gap in the ED field. We draw on surveys and broader literature to better understand the research-practice gap in ED treatment and reasons for resistance to evidence-based practice. We identify three sources of the research-practice gap: (1) attitudinal factors, (2) differences in the definition of "evidence," and (3) cognitive factors, especially naïve realism and confirmation bias. We affirm the role of science as a safeguard against human fallibility and as a means of bridging the research-practice gap, and delineate key principles of scientific thinking for ED researchers and practitioners. We conclude with proposals for narrowing the research-practice gap in ED treatment and enhancing the quality of interventions for ED clients. Copyright © 2013 Wiley Periodicals, Inc.
Wehbe-Alamah, Hiba
2008-04-01
The purpose of this article is to provide knowledge of traditional Muslim generic (folk) care beliefs, expressions and practices derived from research and descriptive sources, in order to assist nurses and other health care professionals to integrate generic (folk) into professional care practices. Muslim generic (folk) care beliefs and practices related to the caregiving process, health, illness, dietary needs, dress, privacy, modesty, touch, gender relations, eye contact, abortion, contraception, birth, death and bereavement were explored. A discussion involving the use of Leininger's culture care preservation and/or maintenance, culture care accommodation and/or negotiation and culture care repatterning and/or restructuring action modes to bridge the gap between generic (folk) and professional (etic) care practices and to consequently promote culturally congruent care is presented.
Research-Practice Integration in Real Practice Settings: Issues and Suggestions
ERIC Educational Resources Information Center
Cheung, Monit; Ma, Anny K.; Thyer, Bruce A.; Webb, Ann E.
2015-01-01
At the National Bridging the Research and Practice Gap Symposium to discuss evidence-based practice (EBP) in social work, 150 participants attended five breakout groups to address real practice setting applications. These participants from social work academia and practice communities addressed issues and looked for solutions to promote…
Monitoring clinical standards in a chronic peritoneal dialysis program.
Leung, Dora K C
2009-02-01
Multiple factors may influence the effectiveness of a chronic peritoneal dialysis program. Continuous monitoring of various aspects of clinical standards with reviews enhances opportunities for bridging the gap between existing practice and good practice, and good practice to best practice.
Evaluating vehicular-induced bridge vibrations for energy harvesting applications
NASA Astrophysics Data System (ADS)
Reichenbach, Matthew; Fasl, Jeremiah; Samaras, Vasilis A.; Wood, Sharon; Helwig, Todd; Lindenberg, Richard
2012-04-01
Highway bridges are vital links in the transportation network in the United States. Identifying possible safety problems in the approximately 600,000 bridges across the country is generally accomplished through labor-intensive, visual inspections. Ongoing research sponsored by NIST seeks to improve inspection practices by providing real-time, continuous monitoring technology for steel bridges. A wireless sensor network with a service life of ten years that is powered by an integrated energy harvester is targeted. In order to achieve the target ten-year life for the monitoring system, novel approaches to energy harvesting for use in recharging batteries are investigated. Three main sources of energy are evaluated: (a) vibrational energy, (b) solar energy, and (c) wind energy. Assessing the energy produced from vehicular-induced vibrations and converted through electromagnetic induction is the focus of this paper. The goal of the study is to process acceleration data and analyze the vibrational response of steel bridges to moving truck loads. Through spectral analysis and harvester modeling, the feasibility of vibration-based energy harvesting for longterm monitoring can be assessed. The effects of bridge conditions, ambient temperature, truck traffic patterns, and harvester position on the power content of the vibrations are investigated. With sensor nodes continually recharged, the proposed real-time monitoring system will operate off the power grid, thus reducing life cycle costs and enhancing inspection practices for state DOTs. This paper will present the results of estimating the vibration energy of a steel bridge in Texas.
DOT National Transportation Integrated Search
2016-10-01
The study outlined in this report aimed to quantify the available redundancy in pony truss bridge systems : constructed using standard designs and practices in the state of Ohio. A method of conducting refined : three-dimensional nonlinear finite ele...
Low Cost Wireless Fatigue Crack Monitoring System Using RFID Arrays
DOT National Transportation Integrated Search
2018-03-23
The use of welded steel cover plates had been a common design practice to increase beam section capacity in regions ofhigh torsion for decades. Many steel girder bridges with cover plates are still in service. Steel girder bridges are subject to cycl...
Community Garden: A Bridging Program between Formal and Informal Learning
ERIC Educational Resources Information Center
Datta, Ranjan
2016-01-01
Community garden activities can play a significant role in bridging formal and informal learning, particularly in urban children's science and environmental education. It promotes relational methods of learning, discussing, and practicing that will integrate food security, social interactions, community development, environmental activism, and…
ERIC Educational Resources Information Center
Wilcox, Bonita; Manear, John; Slifkin, Josh M.
This volume contains articles about writing, best practice, portfolio assessment, and technology, as well as original poetry and book reviews. Articles in the volume are: "Teaching Writing: Making Connections" (Eric Schott); "Empowering Teachers: A Success Story" (Sandra L. Krivak); "Bridging the Gap between the Classroom and Employment" (Linda C.…
DOT National Transportation Integrated Search
2015-06-01
This research project used wireless smart sensors to develop a cost-effective and practical portable structural health monitoring : system for railroad bridges in North America. The system is designed for periodic deployment rather than as a permanen...
Samosudova, N V; Reutov, V P; Larionova, N P; Chaĭlakhian, L M
2005-01-01
In the present work, cerebellar neural net injury was induced by toxic doses of NO-generative compound (NaNO2). A protective role of glial cells was revealed in such conditions. The present results were compared with those of the previous work concerning the action of high concentration glutamate on the frog cerebellum (Samosudova et al., 1996). In both cases we observed the appearance of spiral-like structures--"wrappers)"--involving several rows of transformed glial processes with smaller width and bridges connecting the inner sides of row (autotypic contact). A statistic analysis was made according to both previous and present data. We calculated the number and width of rows, and intervals between bridges depending on experimental conditions. As the injury increased (stimulation in the NO-presence), the row number in "wrappers" also increased, while the row width and intervals between bridges decreased. The presence of autotypic contacts in glial "wrappers" enables us to suppose the involvement of adhesive proteins--cadherins in its formation. The obtained data suggested that the formation of spiral structures--"wrappers" may be regarded as a compensative-adaptive reaction on the injury of cerebellar neural net glutamate and NO-generative compounds.
Dynamic behaviors of historical wrought iron truss bridges: a field testing case study
NASA Astrophysics Data System (ADS)
Dai, Kaoshan; Wang, Ying; Hedric, Andrew; Huang, Zhenhua
2016-04-01
The U.S. transportation infrastructure has many wrought iron truss bridges that are more than a century old and still remain in use. Understanding the structural properties and identifying the health conditions of these historical bridges are essential to deciding the maintenance or rebuild plan of the bridges. This research involved an on-site full-scale system identification test case study on the historical Old Alton Bridge (a wrought iron truss bridge built in 1884 in Denton, Texas) using a wireless sensor network. The study results demonstrate a practical and convenient experimental system identification method for historical bridge structures. The method includes the basic steps of the in-situ experiment and in-house data analysis. Various excitation methods are studied for field testing, including ambient vibration by wind load, forced vibration by human jumping load, and forced vibration by human pulling load. Structural responses of the bridge under these different excitation approaches were analyzed and compared with numerical analysis results.
Horvath, Jared C; Donoghue, Gregory M
2016-01-01
In Education and the Brain: A Bridge Too Far, John Bruer argues that, although current neuroscientific findings must filter through cognitive psychology in order to be applicable to the classroom, with increased knowledge the neuroscience/education bridge can someday be built. Here, we suggest that translation cannot be understood as a single process: rather, we demonstrate that at least four different 'bridges' can conceivably be built between these two fields. Following this, we demonstrate that, far from being a matter of information lack, a prescriptive neuroscience/education bridge (the one most relevant to Bruer's argument) is a practical and philosophical impossibility due to incommensurability between non-adjacent compositional levels-of-organization: a limitation inherent in all sciences. After defining this concept in the context of biology, we apply this concept to the learning sciences and demonstrate why all brain research must be behaviorally translated before prescriptive educational applicability can be elucidated. We conclude by exploring examples of how explicating different forms of translation and adopting a levels-of-organization framework can be used to contextualize and beneficially guide research and practice across all learning sciences.
NASA Technical Reports Server (NTRS)
Honda, Shuji; Nelson, Gregory; Schubert, Wayne
1993-01-01
Intestinal cells when subjected to oxidative stress or radiation exhibit abnormal nuclear divisions observed as: 1) supernumerary cell divisions in anterior intestinal cells or 2) incomplete nuclear division and the persistence of anaphase bridges between daughter nuclei. Two oxygen sensitive mutants, mev-1 and rad-8 were observed to exhibit spontaneous supernumerary nuclear divisions at low frequency. N2 can be induced to undergo these divisions by treatment with the superoxide dismutase (SOD) inhibitor diethyl dithicarbamate or with the free radical generator methyl viologen. By contrast, the free radical generator bleomycin produces anaphase bridges in N2 intestinal nuclei at high frequency. Intestinal anaphase bridges can be induced by ionizing radiation and their formation is dependent on dose and radiation type.
Phlebotomy, a bridge between laboratory and patient.
Ialongo, Cristiano; Bernardini, Sergio
2016-01-01
The evidence-based paradigm has changed and evolved medical practice. Phlebotomy, which dates back to the age of ancient Greece, has gained experience through the evolution of medicine becoming a fundamental diagnostic tool. Nowadays it connects the patient with the clinical laboratory dimension building up a bridge. However, more often there is a gap between laboratory and phlebotomist that causes misunderstandings and burdens on patient safety. Therefore, the scope of this review is delivering a view of modern phlebotomy to "bridge" patient and laboratory. In this regard the paper describes devices, tools and procedures in the light of the most recent scientific findings, also discussing their impact on both quality of blood testing and patient safety. It also addresses the issues concerning medical aspect of venipuncture, like the practical approach to the superficial veins anatomy, as well as the management of the patient's compliance with the blood draw. Thereby, the clinical, technical and practical issues are treated with the same relevance throughout the entire paper.
State of the practice and art for structural health monitoring of bridge substructures.
DOT National Transportation Integrated Search
2014-05-01
In an age of technological advances, the ability to monitor the performance of bridge foundations has evolved such that both short- and long-term data acquisition of embedded gauges is not only available but also cost effective. Case studies were doc...
TESOL: Current Problems and Classroom Practices.
ERIC Educational Resources Information Center
Wardhaugh, Ronald
This paper attempts to "bridge the gap between the practical orientation of teachers and the theoretical concerns that should underlie practice," Discussed in turn are language, psychology, and pedagogical philosophy. An adequate knowledge of these areas is essential to good classroom practices; every bad practice is evidence of some weakness in…
NASA Astrophysics Data System (ADS)
Gaviña, J. R.; Uy, F. A.; Carreon, J. D.
2017-06-01
There are over 8000 bridges in the Philippines today according to the Department of Public Works and Highways (DPWH). Currently, visual inspection is the most common practice in monitoring the structural integrity of bridges. However, visual inspections have proven to be insufficient in determining the actual health or condition of a bridge. Structural Health Monitoring (SHM) aims to give, in real-time, a diagnosis of the actual condition of the bridge. In this study, SmartBridge Sensor Nodes were installed on an existing concrete bridge with American Association of State Highway and Transportation Officials (AASHTO) Type IV Girders to gather vibration of the elements of the bridge. Also, standards on the effective installation of SmartBridge Sensor Nodes, such as location and orientation was determined. Acceleration readings from the sensor were then uploaded to a server, wherein they are monitored against certain thresholds, from which, the health of the bridge will be derived. Final output will be a portal or webpage wherein the information, health, and acceleration readings of the bridge will be available for viewing. With levels of access set for different types of users, the main users will have access to download data and reports. Data transmission and webpage access are available online, making the SHM system wireless.
Bowler, Rosemarie M; Roels, Harry A; Nakagawa, Sanae; Drezgic, Marija; Diamond, Emily; Park, Robert; Koller, William; Bowler, Russell P; Mergler, Donna; Bouchard, Maryse; Smith, Donald; Gwiazda, Roberto; Doty, Richard L
2007-03-01
Although adverse neuropsychological and neurological health effects are well known among workers with high manganese (Mn) exposures in mining, ore-processing and ferroalloy production, the risks among welders with lower exposures are less well understood. Confined space welding in construction of a new span of the San Francisco-Oakland Bay Bridge without adequate protection was studied using a multidisciplinary method to identify the dose-effect relationship between adverse health effects and Mn in air or whole blood. Bridge welders (n = 43) with little or no personal protection equipment and exposed to a welding fume containing Mn, were administered neurological, neuropsychological, neurophysiological and pulmonary tests. Outcome variables were analysed in relation to whole blood Mn (MnB) and a Cumulative Exposure Index (CEI) based on Mn-air, duration and type of welding. Welders performed a mean of 16.5 months of welding on the bridge, were on average 43.8 years of age and had on average 12.6 years of education. The mean time weighted average of Mn-air ranged from 0.11-0.46 mg/m(3) (55% >0.20 mg/m(3)). MnB >10 microg/l was found in 43% of the workers, but the concentrations of Mn in urine, lead in blood and copper and iron in plasma were normal. Forced expiratory volume at 1s: forced vital capacity ratios (FEV(1)/FVC) were found to be abnormal in 33.3% of the welders after about 1.5 years of welding at the bridge. Mean scores of bradykinesia and Unified Parkinson Disease Rating Scale exceeded 4 and 6, respectively. Computer assisted tremor analysis system hand tremor and body sway tests, and University of Pennsylvania Smell Identification Test showed impairment in 38.5/61.5, 51.4 and 88% of the welders, respectively. Significant inverse dose-effect relationships with CEI and/or MnB were found for IQ (p
Practice-Based Research: Another Pathway for Closing the Research-Practice Gap
ERIC Educational Resources Information Center
Crooke, Pamela J.; Olswang, Lesley B.
2015-01-01
Purpose: Practice-based research is proposed as an additional way to bridge the divide between research and practice. Method: The article compares the traditional, laboratory-based research with research that is generated from practice: practice-based research. The defining features of each are described, with an emphasis on contrasting internal…
Hershenberg, Rachel; Drabick, Deborah A. G.; Vivian, Dina
2013-01-01
Clinical researchers and clinical practitioners share a goal of increasing the integration of research and clinical practice, which is reflected in an evidence-based practice (EBP) approach to psychology. The EBP framework involves the integration of research findings with clinical expertise and client characteristics, values, and preferences, and consequently provides an important foundation for conducting clinically relevant research, as well as empirically based and clinically sensitive practice. Given the critical role that early training can play in the integration of science and practice and in promoting the future of the field, the present article addresses predoctoral training programs as a context for adopting an EBP approach to clinical work. We address training in the three components of EBP and provide suggestions for curriculum development and practicum training that we hope will contribute to bridging the gap between research and practice. PMID:22642520
Walking the bridge: Nursing students' learning in clinical skill laboratories.
Ewertsson, Mona; Allvin, Renée; Holmström, Inger K; Blomberg, Karin
2015-07-01
Despite an increasing focus on simulation as a learning strategy in nursing education, there is limited evidence on the transfer of simulated skills into clinical practice. Therefore it's important to increase knowledge of how clinical skills laboratories (CSL) can optimize students' learning for development of professional knowledge and skills, necessary for quality nursing practice and for patient safety. Thus, the aim was to describe nursing students' experiences of learning in the CSL as a preparation for their clinical practice. Interviews with 16 students were analysed with content analysis. An overall theme was identified - walking the bridge - in which the CSL formed a bridge between the university and clinical settings, allowing students to integrate theory and practice and develop a reflective stance. The theme was based on categories: conditions for learning, strategies for learning, tension between learning in the skills laboratory and clinical settings, and development of professional and personal competence. The CSL prepared the students for clinical practice, but a negative tension between learning in CSL and clinical settings was experienced. However, this tension may create reflection. This provides a new perspective that can be used as a pedagogical approach to create opportunities for students to develop their critical thinking. Copyright © 2015 Elsevier Ltd. All rights reserved.
State-of-the-art report on rapid repair techniques for bridge decks.
DOT National Transportation Integrated Search
1990-01-01
Bridges that are candidates for rapid repair techniques have peak-hour traffic volumes that are so high that it is not practical to close a lane to repair the deck or to install a deck protection system except during off-peak traffic periods. This re...
ISD Model Building: From Tabula Rasa to Apple Peel
ERIC Educational Resources Information Center
Ruark, Benjamin E.
2008-01-01
An evidence-based practice (EBP) model is proposed to replace the more-art-than-science "rope bridge" currently spanning the defining space of a training need and the designing space of a training curriculum. The rope bridge analogy symbolizes a way to address perceived deficiencies and research gaps in the…
Focus on Student Success: Components for Effective Summer Bridge Programs
ERIC Educational Resources Information Center
Gonzalez Quiroz, Alicia; Garza, Nora R.
2018-01-01
Using research focused on best practices, focus group information, and data analytics, the Title V: Focus on Student Success (FOSS) Grant created a model for the development, implementation, and evaluation of a summer bridge program. Results included increased academic performance indicators in first-year Hispanic college students. Validation for…
Principled Practical Knowledge: Not a Bridge but a Ladder
ERIC Educational Resources Information Center
Bereiter, Carl
2014-01-01
The much-lamented gap between theory and practice in education cannot be filled by practical knowledge alone or by explanatory knowledge alone. Principled practical knowledge (PPK) is a type of knowledge that has characteristics of both practical know-how and scientific theory. Like basic scientific theory, PPK meets standards of explanatory…
The Practicality of Principled Practical Knowledge: A Response to Janssen, Westbroek, and Doyle
ERIC Educational Resources Information Center
Bereiter, Carl
2015-01-01
"Practicality Studies" (Janssen, Westbroek, & Doyle, 2015/this issue) starts with a critical commentary on "Principled Practical Knowledge: Not a Bridge but a Ladder" (Bereiter, 2014) but consists in the main of an essay on what the authors consider to be "really" practical knowledge for teachers. The gist of…
Effects of low-dose alcohol exposure on simulated merchant ship piloting by maritime cadets.
Howland, J; Rohsenow, D J; Cote, J; Gomez, B; Mangione, T W; Laramie, A K
2001-03-01
The US Department of Transportation (DOT) regulates on-the-job alcohol use by operators of certain categories of commercial transport. For aircraft, trains, and commercial vessels, operators are subject to sanctions for having > or = 0.04 g% blood alcohol concentration (BAC). This study examines the effects of alcohol (between 0.04 and 0.05 g% BAC) on simulated merchant ship handling. A two-group randomized factorial design was used to compare beverage alcohol to placebo while controlling for baseline performance on a previous day. The study was conducted in the Maritime Simulation Center at Maine Maritime Academy, Castine, ME. Participants were 38 volunteer deck officer cadets in their junior or senior year, at least 21 years of age, with previous experience on a bridge simulator. Following a baseline trial on Day 1, on Day 2 participants were randomized to receive alcohol (0.6 g/kg for males and 0.5 g/kg for females) or placebo. After allowing time for absorption, participants completed a bridge simulator task. For baseline and performance trials, participants were randomized to one of four bridge simulator scenarios, each representing passage of a fully loaded container vessel through a channel with commercial traffic. The aggregate scenario score given by blinded maritime educators measured performance. A main effect for alcohol was found indicating that performance was significantly impaired by this low dose of alcohol relative to performance in the placebo condition. These findings are consistent with current federal regulations that limit low-dose alcohol exposure for the operators of commercial transport vehicles. Further research is required to determine effects at lower BACs.
NASA Astrophysics Data System (ADS)
Bayat, M.; Daneshjoo, F.; Nisticò, N.
2017-01-01
In this study the probable seismic behavior of skewed bridges with continuous decks under earthquake excitations from different directions is investigated. A 45° skewed bridge is studied. A suite of 20 records is used to perform an Incremental Dynamic Analysis (IDA) for fragility curves. Four different earthquake directions have been considered: -45°, 0°, 22.5°, 45°. A sensitivity analysis on different spectral intensity meas ures is presented; efficiency and practicality of different intensity measures have been studied. The fragility curves obtained indicate that the critical direction for skewed bridges is the skew direction as well as the longitudinal direction. The study shows the importance of finding the most critical earthquake in understanding and predicting the behavior of skewed bridges.
Bystander signaling in C. elegans: proton microbeam studies
Nelson, Gregory; Jones, Tamako; Ortloff, Leticia; Ford, John; Nuñez, Delia; Braby, Leslie
2014-01-01
Biological model: In this project, we investigated the control of radiation-induced genotoxic damage expression in somatic cells of the nematode Caenorhabditis elegans. We measured genotoxic damage in the C. elegans intestine by irradiating young larvae with 20 intestinal cells. Fourteen of these cells undergo exactly one nuclear division without cytoplasmic division leading to 14 binucleate cells. This nuclear division is synchronized and occurs at the first larval molt. Irradiation induces chromosome aberrations including dicentrics which we can quantify as stable anaphase bridges in the binucleate cells of young adult intestines. The endpoint is dose- and LET-dependent and we have demonstrated that individual intestinal cells have unique radiosensitivities. Results: The project has two components, a genetic screen for genes that control cell sensitivity and a microbeam component to directly probe individual cells. The genetic screen has identified several genes in NHEJ repair and telomere metabolism that modulate overall bridge frequency. Knockout mutants of cku-70, cku-80 and lig-4 greatly sensitize animals for anaphase bridge induction. A statistical method was used to determine whether induction of bridges was strictly random and cell autonomous and we determined that expression of bridges in pairs of cells was, in fact, non-random which suggested that signaling between cells affected the pattern of bridge expression. This allowed us to conduct an RNAi and mutation screen for genes that control the signaling (block non-random distributions) and several candidates have been identified. To directly test the notion that signaling of genotoxic damage occurs, we conducted experiments with alpha particles collimated through slits in metal foils and showed that genotoxic damage could be expressed many cell diameters away from a partial body exposure site. Thus, an in vivo bystander effect was demonstrated. Dose targeting was then improved to small regional exposures and eventually to individual cell targeting using 2 MeV protons from the microbeam facility at Texas A&M University. We now employ a green fluorescent protein (GFP)-expressing transgenic worm (rrIs1[elt-2::GFP]) to target GFP-positive gut cells via the gut-specific transcription factor elt-2. This allows alignment of the cell of interest over the microbeam aperture under appropriate fluorescence illumination. Microbeam irradiation experiments for many pairwise combinations of cell signal transmission and reception (observed as expression of anaphase bridges) have been conducted and several interesting patterns emerge. (i) The signaling pattern is cell-specific and does not simply reflect cell–cell distance or require direct contact between cell pairs. (ii) The signal range can be as far as from cell pair 2 to cell pair 8 (>100 µm). (iii) There appears to be a functional compartment boundary at the pharynx/intestine valve as even high-dose exposures to the posterior pharyngeal bulb fail to induce bridges in nearby intestinal cells. (iv) The frequency of signal transmission and reception corresponds broadly to the overall frequency of bridges observed during whole-body irradiations which suggests that direct irradiation and ‘out-of-field’ effects may be additive. These patterns have been analyzed in terms of a cellular logic circuit map for signal transmission and reception. A dose–response for a subset of microbeam-targeted cells was measured over the range of 5–20 Gy. Controlled cell pair targeting was used to test the potential additivity of signals and we found that effects were supra-additive. Finally, preliminary measurements were conducted on GFP-expressing transgenic strains that bore cku-70(tm1524) III and smk-1(mn156) V mutations which confer enhanced radiosensitivity. Cku-70 is a Ku-70 ortholog while smk-1 is orthologous to the mammalian and Dictyostelium discoideum SMEK (suppressor of MEK null) protein. In the cku-70(0/0) strain, the severity of the bridges in bystander cells was enhanced, suggesting that signal recipient cells employ NHEJ repair pathways in the expression of anaphase bridges. Clinical trial registration number: Not applicable.
DOT National Transportation Integrated Search
1974-01-01
In response to its own research and observations in the early 1960's the Virginia Department of Highways mounted an intensive and extensive effort to improve the performance of concrete in bridge decks. Major elements of this effort included (1) a tr...
Bridging the Gap: The Halifax New Teacher Support Program
ERIC Educational Resources Information Center
Power, Alayne
2013-01-01
New teachers require specific and targeted support, as witnessed by alarming rates of attrition in their first years in the profession. Research shows they often struggle to bridge the gap between their university study and effective practice, especially with issues such as assessment, classroom management and diversity. New teachers should have…
Interdisciplinary Art Education: Building Bridges to Connect Disciplines and Cultures
ERIC Educational Resources Information Center
Strokrocki, Mary, Ed.
2005-01-01
The influence of discipline-based art education has been transformed into new avenues for teaching and learning that require an array of bridges to traverse creating new approaches and settings for art teaching and learning. The concept of interdisciplinary learning is one that should be scrutinized closely and research and practical applications…
49 CFR 237.73 - Protection of bridges from over-weight and over-dimension loads.
Code of Federal Regulations, 2012 CFR
2012-10-01
... trains over its bridges to prevent the operation of cars, locomotives and other equipment that would... and equipment length, in conformance with common railroad industry practice for reporting dimensions... section measurement, followed by the width of the car of the shipment at that height. (d) The instructions...
49 CFR 237.73 - Protection of bridges from over-weight and over-dimension loads.
Code of Federal Regulations, 2014 CFR
2014-10-01
... trains over its bridges to prevent the operation of cars, locomotives and other equipment that would... and equipment length, in conformance with common railroad industry practice for reporting dimensions... section measurement, followed by the width of the car of the shipment at that height. (d) The instructions...
49 CFR 237.73 - Protection of bridges from over-weight and over-dimension loads.
Code of Federal Regulations, 2013 CFR
2013-10-01
... trains over its bridges to prevent the operation of cars, locomotives and other equipment that would... and equipment length, in conformance with common railroad industry practice for reporting dimensions... section measurement, followed by the width of the car of the shipment at that height. (d) The instructions...
Nucleoplasmic bridges as a biomarker of DNA damage exposed to radon.
Meenakshi, C; Sivasubramanian, K; Venkatraman, B
2017-02-01
Radon is a naturally occurring radionuclide in the environment, during decay it emits high linear energy transfer (LET) alpha particles. When radon exposure is accompanied by smoking it has been reported that lung cancer risk is higher. Blood samples were collected after prior consent, 25 smokers and 25 non smokers (only males) exposed in vitro to radon gas with doses ranging between 0.3-12.6mGy Ionizing radiation is a strong clastogenic agent and a potent inducer of MN. Cytokinesis-Blocked Micro Nucleus (CBMN) assay has proven to be a reliable, thoroughly validated and standardised technique in the field of radiation biology. In view of this, an invitro study has been undertaken using CBMN assay to suggest Nucleoplasmic bridges (NPBs) as a potential bio-dosimeter and to investigate the existence of a possible influence of smoking on genetic damage induced by ionizing radiation. The mean percentages frequencies of micronuclei, nucleoplasmic bridges and nuclear buds among the exposed smoker group were 4.82±0.271, 0.6±0.04 and 0.12±0.02 respectively and these values for exposed non-smoker group were 2.78±0.285, 0.4±0.04 and 0.06±0.01 respectively. Spearman rank correlation for the frequency of nucleoplasmic bridge with respect to dose was considered to be significant (P<0.05) in non-smokers. This study is first of its kind to investigate NPB as a biomarker of early DNA damage induced by radon. Copyright © 2017 Elsevier B.V. All rights reserved.
ERIC Educational Resources Information Center
Jenkins, Sandra K.; Thomas, Mary Beth
2005-01-01
Both theoretical thinking and practical wisdom are used by health professionals in their clinical practice. Lately, discussion has centered on the abstract phrase "theory-practice gap." The health profession is not the only discipline that seeks unity in theory and practice issues. Education is also building bridges in this arena. One reoccurring…
O'Donnell, Martin J; Kearon, Clive; Johnson, Judy; Robinson, Marlene; Zondag, Michelle; Turpie, Irene; Turpie, Alexander G
2007-02-06
Preoperative low-molecular-weight heparin (LMWH) is often used when warfarin therapy is interrupted for surgery. To determine the preoperative anticoagulant activity of LMWH following a standardized "bridging" regimen. Prospective cohort study. Single university hospital. Consecutive patients who had warfarin therapy interrupted before an invasive procedure. Enoxaparin, 1 mg/kg of body weight, twice daily. The last dose was administered the evening before surgery. Blood anti-factor Xa heparin levels measured shortly before surgery. Preoperative anti-Xa heparin levels were obtained in 80 patients at an average of 14 hours after the last dose of enoxaparin was administered. The average anti-Xa heparin level was 0.6 U/mL. The anti-Xa heparin level, measured shortly before surgery, was 0.5 U/mL or greater in 54 (68%) patients and 1.0 U/mL or greater in 13 (16%) patients. A shorter interval since the last dose (P < 0.001) and a higher body mass index (P = 0.001) were associated with higher preoperative anti-Xa heparin levels. The small sample size limits accurate estimates of the frequency of the clinical outcomes. A single regimen of LMWH was evaluated. Anti-Xa heparin levels often remain high at the time of surgery if a last dose of a twice-daily regimen of LMWH is given the evening before surgery.
Aesthetic coatings for concrete bridge components
NASA Astrophysics Data System (ADS)
Kriha, Brent R.
This thesis evaluated the durability and aesthetic performance of coating systems for utilization in concrete bridge applications. The principle objectives of this thesis were: 1) Identify aesthetic coating systems appropriate for concrete bridge applications; 2) Evaluate the performance of the selected systems through a laboratory testing regimen; 3) Develop guidelines for coating selection, surface preparation, and application. A series of site visits to various bridges throughout the State of Wisconsin provided insight into the performance of common coating systems and allowed problematic structural details to be identified. To aid in the selection of appropriate coating systems, questionnaires were distributed to coating manufacturers, bridge contractors, and various DOT offices to identify high performing coating systems and best practices for surface preparation and application. These efforts supplemented a literature review investigating recent publications related to formulation, selection, surface preparation, application, and performance evaluation of coating materials.
Sendi, Pedram; Al, Maiwenn J; Gafni, Amiram; Birch, Stephen
2004-05-01
Bridges and Terris (Soc. Sci. Med. (2004)) critique our paper on the alternative decision rule of economic evaluation in the presence of uncertainty and constrained resources within the context of a portfolio of health care programs (Sendi et al. Soc. Sci. Med. 57 (2003) 2207). They argue that by not adopting a formal portfolio theory approach we overlook the optimal solution. We show that these arguments stem from a fundamental misunderstanding of the alternative decision rule of economic evaluation. In particular, the portfolio theory approach advocated by Bridges and Terris is based on the same theoretical assumptions that the alternative decision rule set out to relax. Moreover, Bridges and Terris acknowledge that the proposed portfolio theory approach may not identify the optimal solution to resource allocation problems. Hence, it provides neither theoretical nor practical improvements to the proposed alternative decision rule.
Building more solid bridges between Buddhism and Western psychology.
Sugamura, Genji; Haruki, Yutaka; Koshikawa, Fusako
2007-12-01
Introducing the ways of cultivating mental balance, B. A. Wallace and S. L. Shapiro attempted to build bridges between Buddhism and psychology. Their systematic categorization of Buddhist teachings and extensive review of empirical support from Western psychology are valuable for future study. However, it remains a matter of concern that some more profound parts of Buddhist philosophy can be disregarded by focusing only on practical aspects of Buddhism within the context of mental health. In this comment, the authors briefly address four substantial themes to be considered: reality, identity, causality, and logicality. They suggest that the way to interpret Buddhism as techniques for well-being would certainly be viable in encouraging the study of Buddhist teachings in psychology. Yet, such attempts should not result in superficial imports and applications of Buddhist practices but give due weight to the deeper philosophical issues to build more solid bridges between Buddhism and psychology. (Copyright) 2007 APA.
The Use of Peer Assessment in a Regional Australian University Tertiary Bridging Course
ERIC Educational Resources Information Center
Chambers, Kelly; Whannell, Robert; Whannell, Patricia
2014-01-01
This paper presents the findings from research on peer assessment practice that was specifically focussed on improving the experience in a tertiary bridging course. The objective of the study was to examine the impact of this assessment approach on student social relationships and the overall assessment experience. The study also examined whether…
ERIC Educational Resources Information Center
Lin, Ching Ching
2014-01-01
Bakhtin's dialogism provides a sociocultural approach that views language as a social practice informed by the complex interaction between discourse and meaning. Drawing on this theoretical framework, I argue that a dialogized version of storytelling can be helpful in creating a reflective form of academic discourse that bridges the gap between…
Conceptual Change, Productive Practices, and Themata: Supporting Chemistry Classroom Talk
ERIC Educational Resources Information Center
Criswell, Brett A.; Rushton, Gregory T.
2012-01-01
Vygotsky described the distinction between the "appearance and essence of things" as generating the need for science; he also discussed how this difference is responsible for the fundamental challenge faced by science teachers, as it often requires them to have to build bridges between students' ideas and those of science. Those bridges are often…
ERIC Educational Resources Information Center
Wang, Xiqiao
2017-01-01
The study is situated in a bridge writing course that serves multilingual international students during their first year in college. Based on interviews with 36 Chinese international students and detailed tracing of one focal student's literacy activities, this study examines the social production of a translocal literacy learning space that spans…
Program Evaluation Theory and Practice: A Comprehensive Guide
ERIC Educational Resources Information Center
Mertens, Donna M.; Wilson, Amy T.
2012-01-01
This engaging text takes an evenhanded approach to major theoretical paradigms in evaluation and builds a bridge from them to evaluation practice. Featuring helpful checklists, procedural steps, provocative questions that invite readers to explore their own theoretical assumptions, and practical exercises, the book provides concrete guidance for…
From bed to bench: bridging from informatics practice to theory: an exploratory analysis.
Haux, R; Lehmann, C U
2014-01-01
In 2009, Applied Clinical Informatics (ACI)--focused on applications in clinical informatics--was launched as a companion journal to Methods of Information in Medicine (MIM). Both journals are official journals of the International Medical Informatics Association. To explore which congruencies and interdependencies exist in publications from theory to practice and from practice to theory and to determine existing gaps. Major topics discussed in ACI and MIM were analyzed. We explored if the intention of publishing companion journals to provide an information bridge from informatics theory to informatics practice and vice versa could be supported by this model. In this manuscript we will report on congruencies and interdependences from practice to theory and on major topics in MIM. Retrospective, prolective observational study on recent publications of ACI and MIM. All publications of the years 2012 and 2013 were indexed and analyzed. Hundred and ninety-six publications were analyzed (ACI 87, MIM 109). In MIM publications, modelling aspects as well as methodological and evaluation approaches for the analysis of data, information, and knowledge in biomedicine and health care were frequently raised - and often discussed from an interdisciplinary point of view. Important themes were ambient-assisted living, anatomic spatial relations, biomedical informatics as scientific discipline, boosting, coding, computerized physician order entry, data analysis, grid and cloud computing, health care systems and services, health-enabling technologies, health information search, health information systems, imaging, knowledge-based decision support, patient records, signal analysis, and web science. Congruencies between journals could be found in themes, but with a different focus on content. Interdependencies from practice to theory, found in these publications, were only limited. Bridging from informatics theory to practice and vice versa remains a major component of successful research and practice as well as a major challenge.
Vulnerability of bridges to scour: insights from an international expert elicitation workshop
NASA Astrophysics Data System (ADS)
Lamb, Rob; Aspinall, Willy; Odbert, Henry; Wagener, Thorsten
2017-08-01
Scour (localised erosion) during flood events is one of the most significant threats to bridges over rivers and estuaries, and has been the cause of numerous bridge failures, with damaging consequences. Mitigation of the risk of bridges being damaged by scour is therefore important to many infrastructure owners, and is supported by industry guidance. Even after mitigation, some residual risk remains, though its extent is difficult to quantify because of the uncertainties inherent in the prediction of scour and the assessment of the scour risk. This paper summarises findings from an international expert workshop on bridge scour risk assessment that explores uncertainties about the vulnerability of bridges to scour. Two specialised structured elicitation methods were applied to explore the factors that experts in the field consider important when assessing scour risk and to derive pooled expert judgements of bridge failure probabilities that are conditional on a range of assumed scenarios describing flood event severity, bridge and watercourse types and risk mitigation protocols. The experts' judgements broadly align with industry good practice, but indicate significant uncertainty about quantitative estimates of bridge failure probabilities, reflecting the difficulty in assessing the residual risk of failure. The data and findings presented here could provide a useful context for the development of generic scour fragility models and their associated uncertainties.
Singh, Vijay K; Wise, Stephen Y; Fatanmi, Oluseyi O; Beattie, Lindsay A; Seed, Thomas M
2014-06-01
The authors demonstrate the efficacy of a bridging therapy in a preclinical animal model that allows the lymphohematopoietic system of severely immunocompromised individuals exposed to acute, high-dose ionizing irradiation to recover and to survive. CD2F1 mice were irradiated acutely with high doses causing severe, potentially fatal hematopoietic or gastrointestinal injuries and then transfused intravenously with progenitor-enriched, whole blood, or peripheral blood mononuclear cells from mice injected with tocopherol succinate- and AMD3100- (a chemokine receptor anatogonist used to improve the yield of mobilized progenitors). Survival of these mice over a 30-d period was used as the primary measured endpoint of therapeutic effectiveness. The authors demonstrate that tocopherol succinate and AMD3100 mobilize progenitors into peripheral circulation and that the infusion of mobilized progenitor enriched blood or mononuclear cells acts as a bridging therapy for lymphohematopoietic system recovery in mice exposed to whole-body ionizing irradiation. The results demonstrate that infusion of whole blood or blood mononuclear cells from tocopherol succinate (TS)- and AMD3100-injected mice improved the survival of mice receiving high radiation doses significantly. The efficacy of TS-injected donor mice blood or mononuclear cells was comparable to that of blood or cells obtained from mice injected with granulocyte colony-stimulating factor. Donor origin-mobilized progenitors were found to localize in various tissues. The authors suggest that tocopherol succinate is an optimal agent for mobilizing progenitors with significant therapeutic potential. The extent of progenitor mobilization that tocopherol succinate elicits in experimental mice is comparable quantitatively to clinically used drugs such as granulocyte-colony stimulating factor and AMD3100. Therefore, it is proposed that tocopherol succinate be considered for further translational development and ultimately for use in humans.
Rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation – the J-ROCKET AF study –.
Hori, Masatsugu; Matsumoto, Masayasu; Tanahashi, Norio; Momomura, Shin-ichi; Uchiyama, Shinichiro; Goto, Shinya; Izumi, Tohru; Koretsune, Yukihiro; Kajikawa, Mariko; Kato, Masaharu; Ueda, Hitoshi; Iwamoto, Kazuya; Tajiri, Masahiro
2012-01-01
The global ROCKET AF study evaluated once-daily rivaroxaban vs. warfarin for stroke and systemic embolism prevention in patients with atrial fibrillation (AF). A separate trial, J-ROCKET AF, compared the safety of a Japan-specific rivaroxaban dose with warfarin administered according to Japanese guidelines in Japanese patients with AF. J-ROCKET AF was a prospective, randomized, double-blind, phase III trial. Patients (n=1,280) with non-valvular AF at increased risk for stroke were randomized to receive 15 mg once-daily rivaroxaban or warfarin dose-adjusted according to Japanese guidelines. The primary objective was to determine non-inferiority of rivaroxaban against warfarin for the principal safety outcome of major and non-major clinically relevant bleeding, in the on-treatment safety population. The primary efficacy endpoint was the composite of stroke and systemic embolism. Non-inferiority of rivaroxaban to warfarin was confirmed; the rate of the principal safety outcome was 18.04% per year in rivaroxaban-treated patients and 16.42% per year in warfarin-treated patients (hazard ratio [HR] 1.11; 95% confidence interval 0.87-1.42; P<0.001 [non-inferiority]). Intracranial hemorrhage rates were 0.8% with rivaroxaban and 1.6% with warfarin. There was a strong trend for a reduction in the rate of stroke/systemic embolism with rivaroxaban vs. warfarin (HR, 0.49; P=0.050). J-ROCKET AF demonstrated the safety of a Japan-specific rivaroxaban dose and supports bridging the global ROCKET AF results into Japanese clinical practice.
Practice of One Health approaches: bridges and barriers in Tanzania.
Kayunze, Kim A; Kiwara, Angwara; Lyamuya, Eligius; Kambarage, Dominic M; Rushton, Jonathan; Coker, Richard; Kock, Richard
2014-04-23
The practice of one health approaches in human and animal health programmes is influenced by type and scope of bridges and barriers for partnerships. It was thus essential to evaluate the nature and scope of collaborative arrangements among human, animal, and wildlife health experts in dealing with health challenges which demand inter-sectoral partnership. The nature of collaborative arrangement was assessed, and the respective bridges and barriers over a period of 12 months (July 20011 to June 2012) were identified. The specific objectives were to: (1) determine the proportion of health experts who had collaborated with other experts of disciplines different from theirs, (2) rank the general bridges for and barriers against collaboration according to the views of the health experts, and (3) find the actual bridges for and barriers against collaboration among the health experts interviewed. It was found that 27.0% of animal health officers interviewed had collaborated with medical officers while 12.4% of the medical officers interviewed had collaborated with animal health experts. Only 6.7% of the wildlife officers had collaborated with animal health experts. The main bridges for collaboration were instruction by upper level leaders, zoonotic diseases of serious impacts, and availability of funding. The main barriers for collaboration were lack of knowledge about animal/human health issues, lack of networks for collaboration, and lack of plans to collaborate. This thus calls for the need to curb barriers in order to enhance inter-sectoral collaboration for more effective management of risks attributable to infectious diseases of humans and animals.
Bridging the Research-to-Practice Gap: A Review of the Literature Focusing on Inclusive Education
ERIC Educational Resources Information Center
Grima-Farrell, Christine R.; Bain, Alan; McDonagh, Sarah H.
2011-01-01
Despite advances in our knowledge of evidence-based inclusive educational practice, much of this knowledge does not reach routine classroom practice. There remains a significant gap between our accumulated knowledge about what can work in classrooms and the extent to which evidence-based practice is used in sustainable ways. This inability to…
Supporting Children's Mental Health in Schools: Teacher Perceptions of Needs, Roles, and Barriers
ERIC Educational Resources Information Center
Reinke, Wendy M.; Stormont, Melissa; Herman, Keith C.; Puri, Rohini; Goel, Nidhi
2011-01-01
There is a significant research to practice gap in the area of mental health practices and interventions in schools. Understanding the teacher perspective can provide important information about contextual influences that can be used to bridge the research to practice gap in school-based mental health practices. The purpose of this study was to…
Practitioners as Researchers: Bridging Theory and Practice.
ERIC Educational Resources Information Center
Hirsch, Deborah
2000-01-01
Discusses the "think tank" programs of the New England Resource Center for Higher Education that enable college administrators to become more reflective about their practice and to conduct research that is rooted in practice. The think tanks are day-long seminars for chief student affairs officers, chief academic officers, associate academic…
A History of Thought and Practice in Educational Administration.
ERIC Educational Resources Information Center
Campbell, Roald F.; And Others
Historical reconstruction bridges the gulf between theory and practice extant in educational administration. This book characterizes evolution of administrative thought and practice in the United States. An introduction summarizes methods incorporated by this applied field from diverse administrative systems. Chapters 2 and 3 advance two of four…
Belonging in a Videogame Space: Bridging Affinity Spaces and Communities of Practice
ERIC Educational Resources Information Center
Abrams, Sandra Schamroth; Lammers, Jayne C.
2017-01-01
Background: Focusing on ways a common endeavor brings people together, Gee offered the concept of affinity spaces, which suggests that open participation without exclusion or membership is possible. This theory contrasts with Lave and Wenger's communities of practice, which called attention to situated, hierarchical participatory practices.…
Bridging the Gap between Research and Practice: Implementation Science
ERIC Educational Resources Information Center
Olswang, Lesley B.; Prelock, Patricia A.
2015-01-01
Purpose: This article introduces implementation science, which focuses on research methods that promote the systematic application of research findings to practice. Method: The narrative defines implementation science and highlights the importance of moving research along the pipeline from basic science to practice as one way to facilitate…
Unraveling Evidence-Based Practices in Special Education
ERIC Educational Resources Information Center
Cook, Bryan G.; Cook, Sara Cothren
2013-01-01
Evidence-based practices (EBPs) are instructional techniques that meet prescribed criteria related to the research design, quality, quantity, and effect size of supporting research, which have the potential to help bridge the research-to-practice gap and improve student outcomes. In this article, the authors (a) discuss the importance of clear…
Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-28
... Brain Injury: Prevention, Diagnosis, Treatment and Recovery for the Iraq and Afghanistan Cohort Notice... Clinical Practice of Psychological Health and Traumatic Brain Injury: Prevention, Diagnosis, Treatment and... clinical practices for psychological health and traumatic brain injury (TBI) health concerns for returning...
Teacher Education: Linking Theory to Practice through Digital Technology
ERIC Educational Resources Information Center
Wursta, Melanie; Brown-DuPaul, Judy; Segatti, Laura
2004-01-01
Teacher education faculty need to bridge college course knowledge to actual practices in early childhood classrooms. Historically, faculty have lectured about best practices and then students have attempted to integrate these concepts into their own teaching with children. This article highlights one community college's use of digital photography…
Wieringa, Nicolien F; Peschar, Jules L; Denig, Petra; de Graeff, Pieter A; Vos, Rein
2003-01-01
To identify core issues that contribute to the gap between pre-marketing clinical research and practice as seen from the perspective of medical practice, as well as possible changes and potential barriers for dosing this gap. Interviews with 47 physicians and pharmacists who were liaised to drug regulation through their role in the pre- and post-marketing shaping of new cardiovascular drugs. Data were analyzed using methods of grounded theory and analytical evaluations. Six core issues were identified that referred to the standards in drug regulation, the organization of the regulatory system, and conflicting interests. Pre-marketing trials should focus more on populations and research questions relevant to medical practice. In particular, variability in drug responses between subgroups of patients and demonstration of effectiveness should become major principles in drug regulation. An interactive post-marketing process in which public interests are represented was considered necessary to further guide research and development according to the needs in daily practice. Strategies for change could be applied within the present system of drug regulation, or affect its basic principles. Regulatory authorities were primarily identified to initiate changes, but many other parties should be involved. Barriers for change were identified regarding differences in interests between parties, organizational matters, and with respect to broader healthcare policies. Based on the respondents' opinions, there is a need to focus regulatory standards more on the needs in medical practice. Therefore, regulatory authorities should further develop their influence in the pre- and post-marketing drug development process, together with other parties involved, in order to bridge the gap between clinical research and medical practice.
ERIC Educational Resources Information Center
Matroos, Sebastian; van Wyk, Barry
2005-01-01
This paper aims to develop a theoretical and practical framework for lifelong learning which will contribute to bridging the development divide, thus facilitating the implementation of the MDGs on both a global and personal level. We see this happening through the direct personal and professional involvement of development professionals (that is,…
ERIC Educational Resources Information Center
Akanbi, Grace Oluremi
2017-01-01
This paper discusses the prospects technical and vocational education and training (TVET) in Nigeria through bridging the gap between the policy document and practice. At the 1969 National Curriculum Conference and the eventual emergence of the National Policy on Education (NPE) in 1977, TVET was given prominence but, unfortunately, in theory…
Copy image of "'Under the Great Arch' of Refectory Bridge ...
Copy image of "'Under the Great Arch' of Refectory Bridge connecting the Dining Room with the Practice House, Delta, and the Villa. The Refectory Cloister is seen beyond the arch"; a similar, but recent, view can be seen in MD-1109-A-16. (NPS view book, p. 25) - National Park Seminary, Main, Linden Lane, Silver Spring, Montgomery County, MD
Horvath, Jared C.; Donoghue, Gregory M.
2016-01-01
In Education and the Brain: A Bridge Too Far, John Bruer argues that, although current neuroscientific findings must filter through cognitive psychology in order to be applicable to the classroom, with increased knowledge the neuroscience/education bridge can someday be built. Here, we suggest that translation cannot be understood as a single process: rather, we demonstrate that at least four different ‘bridges’ can conceivably be built between these two fields. Following this, we demonstrate that, far from being a matter of information lack, a prescriptive neuroscience/education bridge (the one most relevant to Bruer’s argument) is a practical and philosophical impossibility due to incommensurability between non-adjacent compositional levels-of-organization: a limitation inherent in all sciences. After defining this concept in the context of biology, we apply this concept to the learning sciences and demonstrate why all brain research must be behaviorally translated before prescriptive educational applicability can be elucidated. We conclude by exploring examples of how explicating different forms of translation and adopting a levels-of-organization framework can be used to contextualize and beneficially guide research and practice across all learning sciences. PMID:27014173
Roche, Abigail; Goto, Keiko; Zhao, Yanling; Wolff, Cindy
2015-01-01
To examine perceived social and cultural capitals associated with family eating practices among Hmong, Latino, and white mothers and fathers. Six focus groups composed of 52 Hmong, Latino, and white mothers and fathers of young children were conducted to examine parental perceptions of social and cultural capitals associated with eating practices. Whereas Hmong participants unanimously emphasized the healthfulness of their traditional food, Latino groups had divergent views on their traditional foods' healthfulness. Hmong parents highly valued their traditional foods whereas white and Latino mothers were more accepting of new foods from other cultures. Participants noted divergent views on gender roles in family eating practices and food culture preservation efforts. Identifying and promoting bonding and bridging of cultural assets for healthy dietary practices among different cultural groups may be important for developing successful nutrition education programs across ethnicities in the community. Copyright © 2015 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.
Bridging the practitioner-scientist gap in group psychotherapy research.
Lau, Mark A; Ogrodniczuk, John; Joyce, Anthony S; Sochting, Ingrid
2010-04-01
Bridging the practitioner-scientist gap requires a different clinical research paradigm: participatory research that encourages community agency-academic partnerships. In this context, clinicians help define priorities, determine the type of evidence that will have an impact on their practice (affecting the methods that are used to produce the evidence), and develop strategies for translating, implementing, and disseminating their findings into evidence-based practice. Within this paradigm, different roles are assumed by the partners, and sometimes these roles are blended. This paper will consider the perspectives of people who assume these different roles (clinician, researcher, and clinician-researcher) with group psychotherapy as the specific focus. Finally, the establishment of a practice-research network will be discussed as a potentially promising way to better engage group therapists in research.
Reduction of earthquake risk in the united states: Bridging the gap between research and practice
Hays, W.W.
1998-01-01
Continuing efforts under the auspices of the National Earthquake Hazards Reduction Program are under way to improve earthquake risk assessment and risk management in earthquake-prone regions of Alaska, California, Nevada, Washington, Oregon, Arizona, Utah, Wyoming, and Idaho, the New Madrid and Wabash Valley seismic zones in the central United States, the southeastern and northeastern United States, Puerto Rico, Virgin Islands, Guam, and Hawaii. Geologists, geophysicists, seismologists, architects, engineers, urban planners, emergency managers, health care specialists, and policymakers are having to work at the margins of their disciplines to bridge the gap between research and practice and to provide a social, technical, administrative, political, legal, and economic basis for changing public policies and professional practices in communities where the earthquake risk is unacceptable. ?? 1998 IEEE.
MacKinnon, Christopher J; Smith, Nathan Grant; Henry, Melissa; Berish, Mel; Milman, Evgenia; Körner, Annett; Copeland, Laura S; Chochinov, Harvey M; Cohen, S Robin
2014-01-01
A growing body of scholarship has evaluated the usefulness of meaning-based theories in the context of bereavement counseling. Although scholars have discussed the application of meaning-based theories for individual practice, there is a lack of inquiry regarding its implications when conducting bereavement support groups. The objective of this article is to bridge meaning-based theories with bereavement group practice, leading to a novel intervention and laying the foundation for future efficacy studies. Building on recommendations specified in the literature, this article outlines the theoretical paradigms and structure of a short-term meaning-based group counseling intervention for uncomplicated bereavement.
ERIC Educational Resources Information Center
Danielson, Katie A.
2016-01-01
Mary Kennedy (1999) introduced the problem of enactment to describe how novice teachers often struggle to put what they have learned in coursework into practice in the field. One approach to this problem is to put practice at the center of teacher education by specifying core practices of teaching around which to structure novices' learning…
Hakeem, Abdul; Cilingiroglu, Mehmet; Leesar, Massoud A
2010-02-01
Compared to coronary angiography, both intravascular ultrasound (IVUS) and CT-angiography provide important information with respect to the morphological aspects of myocardial bridging (MB). However, these modalities are limited in defining the hemodynamic and clinical significance of MB. Intracoronary Doppler studies demonstrate a peculiar abnormal Doppler flow profile associated with MB. Fractional flow reserve (FFR) after adenosine infusion has been used to assess the hemodynamic significance of MB, but FFR after adenosine induced hyperemia underestimates the significance of MB. On the other hand, high-dose dobutamine by increasing the contractility of the bridging segment unmasks ischemia induced by MB. This review outlines the role of flow velocity measurement by intracoronary Doppler, FFR, and IVUS for assessment of patients with MB. In addition, we compared FFR measurements after adenosine versus dobutamine infusions for the hemodynamic assessment of MB in two patients.
Combining Theory and Practice in the Gymnasium: "Constraints" within an Ecological Perspective
ERIC Educational Resources Information Center
Gagen, Linda; Getchell, Nancy
2004-01-01
Preservice students do not always see the relationship between the theories they learn in motor development class and the practical applications of those theories in the gymnasium. This article begins to bridge the gap between theory and practice. Within the theoretical viewpoint known as the ecological perspective, the authors identify the…
Implementation Practice and Implementation Research: A Report from the Field
ERIC Educational Resources Information Center
Brekke, John S.; Phillips, Elizabeth; Pancake, Laura; O, Anne; Lewis, Jenebah; Duke, Jessica
2009-01-01
The Interventions and Practice Research Infrastructure Program (IPRISP) funding mechanism was introduced by the National Institute of Mental Health (NIMH) to bridge the gap between the worlds of services research and the usual care practice in the community. The goal was to build infrastructure that would provide a platform for research to…
Bridging the Research-Practice Gap: Research Translation and/or Research Transformation
ERIC Educational Resources Information Center
Hirschkorn, Mark; Geelan, David
2008-01-01
The issue of the "research-practice gap"--the problematic relationship between research in education and educational practice--has been widely reported in the literature. This critical literature review explores some of the causes and features of the gap and suggests some possible approaches for addressing it. These solutions involve changes in…
Retirees' motivational orientations and bridge employment: Testing the moderating role of gender.
Zhan, Yujie; Wang, Mo; Shi, Junqi
2015-09-01
Bridge employment refers to the labor force participation after people retire from career jobs. It is becoming a prevalent phenomenon for retirees transitioning from employment to complete work withdrawal. Building on existing literature on retirement transition and older adults' work motivation, the present study examined the effects of 3 motivational orientations (i.e., status striving, communion striving, and generativity striving) in relating to retirees' bridge employment participation (i.e., bridge employment status and bridge employment work hours). This study also applied the social gender role theory to examine the effect of gender in moderating the effects of motivational orientations. Data from 507 Chinese retirees in Beijing revealed that communion striving and generativity striving were positively related to bridge employment participation. Further, gender moderated the effect of status striving such that status striving was positively related to bridge employment participation for male retirees but not for female retirees. In addition, exploratory analysis was conducted to examine the effects of the same set of motivational orientations on postretirement volunteering activities. Results showed that status striving was negatively related to volunteering after retirement. The findings are discussed in terms of their theoretical implications for the bridge employment literature and practical implications for recruiting and retaining older workers. (c) 2015 APA, all rights reserved).
Multi-Hazard Assessment of Scour Damaged Bridges with UAS-Based Measurements
NASA Astrophysics Data System (ADS)
Özcan, O.; Ozcan, O.
2017-12-01
Flood and stream induced scour occurring in bridge piers constructed on rivers is one of the mostly observed failure reasons in bridges. Scour induced failure risk in bridges and determination of the alterations in bridge safety under seismic effects has the ultimate importance. Thus, for the determination of bridge safety under the scour effects, the scour amount under bridge piers should be designated realistically and should be tracked and updated continuously. Hereby, the scour induced failures in bridge foundation systems will be prevented and bridge substructure design will be conducted safely. In this study, in order to measure the amount of scour in bridge load bearing system (pile foundations and pile abutments) and to attain very high definition 3 dimensional models of river flood plain for the flood analysis, unmanned aircraft system (UAS) based measurement methods were implemented. UAS based measurement systems provide new and practical approach and bring high precision and reliable solutions considering recent measurement systems. For this purpose, the reinforced concrete (RC) bridge that is located on Antalya Boğaçayı River, Turkey and that failed in 2003 due to flood-induced scour was selected as the case study. The amount of scour occurred in bridge piers and piles was determined realistically and the behavior of bridge piers under scour effects was investigated. Future flood effects and the resultant amount of scour was determined with HEC-RAS software by using digital surface models that were obtained at regular intervals using UAS for the riverbed. In the light of the attained scour measurements and expected scour after a probable flood event, the behavior of scour damaged RC bridge was investigated by pushover and time history analyses under lateral and vertical seismic loadings. In the analyses, the load and displacement capacity of bridge was observed to diminish significantly under expected scour. Thus, the deterioration in multi hazard performance of the bridge was monitored significantly in the light of updated bridge load bearing system capacity. Regarding the case study, UAS based and continuously updated bridge multi hazard risk detection system was established that can be used for bridges located on riverbed.
Preliminary study on the effect of x-ray irradiation on Capsicum annum
DOE Office of Scientific and Technical Information (OSTI.GOV)
Subhash, K.; Nizam, J.
The present experiment on Capsicum annum was conducted to study various cytological and genetic effects induced by x-ray irradiation. Dry and soaked seeds were exposed to irradiation by deep x rays at the Radium and Cancer Research Institute, Hyderabad at a dose rate of 99 rads/min. The doses administered were as follows: 3000 rads, 4000 rads, 5000 rads, and 10,000 rads. The cytological preparations were made by following Belling's technique. The irradiated seeds along with the controlled were sown in the soil to observe the morphological variations. The root tip squashes from the irradiated seed material revealed various chromosomal aberrationsmore » such as deletions, parallel bridges, and single and paired fragments of acentric chromosomes, showing cytological irregularities. Bridges were quite common at anaphases. The irradiated seeds were germinated in order to record morphological variations. A period of 150 days seems to be necessary from germination to seed formation; this period is not identical for the irradiated and controlled seeds. In some of the irradiated material the duration was reduced to 120 to 130 days. With this observation it may be presumed that mild doses of radiation have accelerated the germination time and also hastened the growth processes. (auth)« less
ERIC Educational Resources Information Center
Nore, Haege; Lahn, Leif Christian
2014-01-01
This article explores the effect that the use of e-portfolios initiated and organized by apprenticeship training offices has had on the learning processes and assessment practices of apprentices in Norwegian vocational education and training. Although these intermediate structures have the potential to bridge the gap between work and education,…
Ileostomy rod--is it a bridge too far?
Speirs, M; Leung, E; Hughes, D; Robertson, I; Donnelly, L; Mackenzie, I; Macdonald, A
2006-07-01
Defunctioning loop ileostomies are used commonly to protect low colorectal anastomoses and thereby reducing the serious complications of leakage. However, they are associated with specific complications such as retraction. Traditionally, a supporting rod is placed as a bridge to support both limbs of the stoma in the hope of reducing the incidence of stomal retraction. There is little evidence in the published literature to support this practice. The aim of this study was to determine whether using an ileostomy rod would reduce the incidence of stomal retraction. A prospective, randomised controlled trial was performed in 60 consecutive patients who required a defunctioning loop ileostomy. Patients were allocated to either a 'bridge' or 'bridge-less' protocol. All the patients were assessed by dedicated stoma nurses for at least 3 months and until their stomas were closed. Their postoperative symptoms, including stoma activity and retraction rate, were recorded. Between May 2001 and June 2004, 57 patients completed the study (28 bridge; 29 bridge-less). There were no significant differences in the retraction rate between the groups. No clinical anastomotic leakage was recorded and none of the patients required early closure. If a loop ileostomy is constructed properly, stomal retraction is uncommon and routine use of a bridge is unnecessary.
Celebi, M.
2006-01-01
This paper introduces the state of the art, real-time and broad-band seismic monitoring network implemented for the 1206 m [3956 ft] long, cable-stayed Bill Emerson Memorial Bridge in Cape Girardeau (MO), a new Mississippi River crossing, approximately 80 km from the epicentral region of the 1811-1812 New Madrid earthquakes. The bridge was designed for a strong earthquake (magnitude 7.5 or greater) during the design life of the bridge. The monitoring network comprises a total of 84 channels of accelerometers deployed on the superstructure, pier foundations and at surface and downhole free-field arrays of the bridge. The paper also presents the high quality response data obtained from the network. Such data is aimed to be used by the owner, researchers and engineers to assess the performance of the bridge, to check design parameters, including the comparison of dynamic characteristics with actual response, and to better design future similar bridges. Preliminary analyses of ambient and low amplitude small earthquake data reveal specific response characteristics of the bridge and the free-field. There is evidence of coherent tower, cable, deck interaction that sometimes results in amplified ambient motions. Motions at the lowest tri-axial downhole accelerometers on both MO and IL sides are practically free from any feedback from the bridge. Motions at the mid-level and surface downhole accelerometers are influenced significantly by feedback due to amplified ambient motions of the bridge. Copyright ASCE 2006.
Wise, Barbara; Dreussi-Smith, Terie
2018-04-01
There is a much recent emphasis on the social determinants of health, and poverty is the most influential of these. It is not enough merely to understand the influence of poverty on health-the primary care provider must understand how to effectively treat patients who live in poverty. This article applies the Bridges to Health and Healthcare model for understanding poverty to primary care practice from an individual provider's perspective. The article walks the reader through the implications of generational poverty for the primary care clinician in a typical office visit from history taking to following up. Most primary care practitioners approach patients from a middle-class perspective. Awareness of the challenges and different perspectives of those in generational poverty can enhance care and outcomes. The individual provider can use the understanding of driving forces, resources, language and cognition, environment, and relationships provided by the Bridges to Health and Healthcare model to benefit patients in generational poverty.
Effect of surfactant on kinetics of thinning of capillary bridges
NASA Astrophysics Data System (ADS)
Nowak, Emilia; Kovalchuk, Nina; Simmons, Mark
2015-11-01
Kinetics of thinning of capillary bridges is of great scientific and industrial interest being of vital importance for example in various emulsification and microfluidic processes. It is well known that the rate of bridge thinning is proportional to the interfacial tension. Therefore it is expected that the process should slow down by addition of surfactant. The kinetics of capillary bridges in the presence of surfactant was studied by the dripping of liquid from a capillary tip under conditions of nearly zero flow rate (We << 1). The tested liquids were aqueous solutions of sodium lauryl ether sulphate (SLES), which is broadly used in personal care products. The viscosity, surfactant activity and adsorption kinetics have been controlled by addition of glycerol and sodium chloride. The study has shown that the kinetics of capillary bridges are determined by dynamic surface tension rather than by its equilibrium value. In particular, the kinetics of the bridge thinning for the 0.1 g L-1 aqueous SLES solution is practically the same as that of pure water despite twice lower equilibrium surface tension. EPSRC Programme Grant, MEMPHIS, EP/K0039761/1.
ERIC Educational Resources Information Center
Kinyaduka, Bryson D.
2017-01-01
This paper raises pertinent issues regarding an obvious gap that prevails between theory and practice in various professions. The paper makes it clear that there is theory-practice gap among professions; however, it focuses more on informing theory-practice gap in the teaching profession. The paper identifies and informs of causes, effects and…
ERIC Educational Resources Information Center
Allen, Jeanne M.
2009-01-01
This paper is about the experiences of beginning teachers in turning theory learned in universities into practice in the workplace. The research is situated in the context of a pre-service teacher education programme that explicitly and deliberately seeks to bridge the theory-practice gap in teacher education. The paper argues that, despite…
Teacher Educators Struggling to Make Complex Practice Explicit: Distancing Teaching through Video
ERIC Educational Resources Information Center
Klein, Emily J.; Taylor, Monica
2017-01-01
This self-study examines our use of video with a cohort of preservice teachers as a means to address the challenges we face as teacher educators who are working with candidates in extensive clinical practice. We came to video as a nuanced way to discuss and make meaning of complex practice and as a means of bridging theory and practice. We found…
Building Bridges from the Decoding Interview to Teaching Practice
ERIC Educational Resources Information Center
Pettit, Jennifer; Rathburn, Melanie; Calvert, Victoria; Lexier, Roberta; Underwood, Margot; Gleeson, Judy; Dean, Yasmin
2017-01-01
This chapter describes a multidisciplinary faculty self-study about reciprocity in service-learning. The study began with each coauthor participating in a Decoding interview. We describe how Decoding combined with collaborative self-study had a positive impact on our teaching practice.
ERIC Educational Resources Information Center
Herrington, Deborah; Daubenmire, Patrick L.
2016-01-01
Despite decades of research regarding best practices for the teaching and learning of chemistry, as well as two sets of national reform documents for science education, classroom instruction in high school chemistry classrooms remains largely unchanged. One key reason for this continued gap between research and practice is a reliance on…
2012 Dewey Lecture: Making Meaning Together beyond Theory and Practice
ERIC Educational Resources Information Center
Garrison, Jim
2013-01-01
Educators frequently fret over how to bridge the gap between theory and practice. In an important sense, it is a false problem. Theory is simply the thoughtful, reflective phase of good practice. We will approach Dewey's philosophy as one of continuous creation and re-creation or even more precisely, social co-creation, that requires making…
ERIC Educational Resources Information Center
Ilhan, Emine Gül Çelebi; Erbas, Ayhan Kürsat
2016-01-01
As is well known, bridging teacher knowledge or learning with practice is not a straightforward task. This paper aims to explore this discrepancy between a mathematics teacher's knowing and practices and to offer ways of alignment between the two based on the social/interpersonal meanings and their realization through teacher's discourse. In this…
Diffusion of Innovation Theory: A Bridge for the Research-Practice Gap in Counseling
ERIC Educational Resources Information Center
Murray, Christine E.
2009-01-01
This article presents a diffusion of innovation theory-based framework for addressing the gap between research and practice in the counseling profession. The author describes the nature of the research-practice gap and presents an overview of diffusion of innovation theory. On the basis of the application of several major postulates of diffusion…
ERIC Educational Resources Information Center
Mehrotra, Gita R.; Tecle, Aster S.; Ha, An Thi; Ghneim, Staci; Gringeri, Christina
2018-01-01
Field education and macro practice have been highlighted as central educational domains in social work education; however, little scholarship has looked at how macro social work practice competencies have been integrated into field-based learning. This exploratory study aimed to gain perspectives from field instructors regarding macro social work…
Excellence in Teaching and Learning: Bridging the Gaps in Theory, Practice, and Policy
ERIC Educational Resources Information Center
Salhi, Adnan, Ed.
2006-01-01
This book represents a collaborative effort among education scholars that addresses the theory, practice, and policy gaps that have plagued classrooms for a long time. Divided into three parts, it focuses on practical strategies for teaching and learning in different subject areas and at all levels; provides research-based models for improving…
Bridge to Removal: A Paradigm Shift for Left Ventricular Assist Device Therapy
Selzman, Craig H.; Madden, Jesse L.; Healy, Aaron H.; McKellar, Stephen H.; Koliopoulou, Antigone; Stehlik, Josef; Drakos, Stavros G.
2014-01-01
Ventricular assist devices have become standard therapy for patients with advanced heart failure either as a bridge to transplantation or destination therapy. Despite the functional and biologic evidence of reverse cardiac remodeling, few patients actually proceed to myocardial recovery, and even fewer to the point of having their device explanted. An enhanced understanding of the biology and care of the mechanically supported patient has redirected focus on the possibility of using ventricular assist devices as a bridge to myocardial recovery and removal. Herein, we review the current issues and approaches to transforming myocardial recovery to a practical reality. PMID:25442985
Practical Nurses' Lived Experience of Returning to School.
Chachula, Kathryn; Smith, Mary; Hyndman, Kathryn
2018-05-25
The lived experience of licensed practical nurses (LPNs) pursuing Bachelor of Nursing (BN) education is not commonly studied in Canada. The aim was to understand the transition experience of LPNs who bridged into a BN program. Max van Manen's phenomenological methodology was used through use of a semistructured interview guide to explore the lived experience of LPNs who pursued baccalaureate nursing education. Five themes were found: seeking advancement; stepping back into the student role; juggling work, school, and family; struggling to be understood; and seeing things differently. LPN-to-BN students have a well-developed sense of identity as nurses. These students can benefit from a specifically designed, stand-alone bridge course to situate them within a BN program.
Test-bed for the remote health monitoring system for bridge structures using FBG sensors
NASA Astrophysics Data System (ADS)
Lee, Chin-Hyung; Park, Ki-Tae; Joo, Bong-Chul; Hwang, Yoon-Koog
2009-05-01
This paper reports on test-bed for the long-term health monitoring system for bridge structures employing fiber Bragg grating (FBG) sensors, which is remotely accessible via the web, to provide real-time quantitative information on a bridge's response to live loading and environmental changes, and fast prediction of the structure's integrity. The sensors are attached on several locations of the structure and connected to a data acquisition system permanently installed onsite. The system can be accessed through remote communication using an optical cable network, through which the evaluation of the bridge behavior under live loading can be allowed at place far away from the field. Live structural data are transmitted continuously to the server computer at the central office. The server computer is connected securely to the internet, where data can be retrieved, processed and stored for the remote web-based health monitoring. Test-bed revealed that the remote health monitoring technology will enable practical, cost-effective, and reliable condition assessment and maintenance of bridge structures.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Park, Kyoungsoo, E-mail: kpark16@illinois.ed; Paulino, Glaucio H.; Roesler, Jeffery
A simple, effective, and practical constitutive model for cohesive fracture of fiber reinforced concrete is proposed by differentiating the aggregate bridging zone and the fiber bridging zone. The aggregate bridging zone is related to the total fracture energy of plain concrete, while the fiber bridging zone is associated with the difference between the total fracture energy of fiber reinforced concrete and the total fracture energy of plain concrete. The cohesive fracture model is defined by experimental fracture parameters, which are obtained through three-point bending and split tensile tests. As expected, the model describes fracture behavior of plain concrete beams. Inmore » addition, it predicts the fracture behavior of either fiber reinforced concrete beams or a combination of plain and fiber reinforced concrete functionally layered in a single beam specimen. The validated model is also applied to investigate continuously, functionally graded fiber reinforced concrete composites.« less
Campbell, Margaret L.; Putnam, Michelle
2017-01-01
Persons aging with long-term disabilities such as spinal cord injury or multiple sclerosis and older adults share similar chronic conditions in mid and later life in the United States. The rising general interest and more prevalent federal requirements for use of evidence-based practices (EBP) in health promotion and chronic condition interventions highlight the gap between demand and the availability of EBPs for persons aging with disability in particular. Addressing this gap will require focused efforts that will benefit substantially by bridging the fields of aging and disability/rehabilitation to develop new EBPs, translate existing EBPs across populations, and borrow best practices across fields where there are few current EBPs. Understanding distinctions between disability-related secondary conditions and age-related chronic conditions is a first step in identifying shared conditions that are important to address for both mid-life and older adults with disabilities. This review articulates these distinctions, describes shared conditions, and discusses the current lack of EBPs for both populations. It also provides recommendations for bridging activities in the United States by researchers, professionals, and consumer advocates. We argue that these can more efficiently move research and practice than if activities were undertaken separately in each field (aging and disability/rehabilitation). PMID:28895898
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hoehler, M; McCallen, D; Noble, C
The analysis, and subsequent retrofit, of concrete arch bridges during recent years has relied heavily on the use of computational simulation. For seismic analysis in particular, computer simulation, typically utilizing linear approximations of structural behavior, has become standard practice. This report presents the results of a comprehensive study of the significance of model sophistication (i.e. linear vs. nonlinear) and pertinent modeling assumptions on the dynamic response of concrete arch bridges. The study uses the Bixby Creek Bridge, located in California, as a case study. In addition to presenting general recommendations for analysis of this class of structures, this report providesmore » an independent evaluation of the proposed seismic retrofit for the Bixby Creek Bridge. Results from the study clearly illustrate a reduction of displacement drifts and redistribution of member forces brought on by the inclusion of material nonlinearity. The analyses demonstrate that accurate modeling of expansion joints, for the Bixby Creek Bridge in particular, is critical to achieve representative modal and transient behavior. The inclusion of near-field displacement pulses in ground motion records was shown to significantly increase demand on the relatively softer, longer period Bixby Creek Bridge arch. Stiffer, shorter period arches, however, are more likely susceptible to variable support motions arising from the canyon topography typical for this class of bridges.« less
NASA Astrophysics Data System (ADS)
Flaga, Kazimierz; Furtak, Kazimierz
2015-03-01
Steel-concrete composite structures have been used in bridge engineering from decades. This is due to rational utilisation of the strength properties of the two materials. At the same time, the reinforced concrete (or prestressed) deck slab is more favourable than the orthotropic steel plate used in steel bridges (higher mass, better vibration damping, longer life). The most commonly found in practice are composite girder bridges, particularly in highway bridges of small and medium spans, but the spans may reach over 200 m. In larger spans steel truss girders are applied. Bridge composite structures are also employed in cable-stayed bridge decks of the main girder spans of the order of 600, 800 m. The aim of the article is to present the cionstruction process and strength analysis problems concerning of this type of structures. Much attention is paid to the design and calculation of the shear connectors characteristic for the discussed objects. The authors focused mainly on the issues of single composite structures. The effect of assembly states on the stresses and strains in composite members are highlighted. A separate part of problems is devoted to the influence of rheological factors, i.e. concrete shrinkage and creep, as well as thermal factors on the stresses and strains and redistribution of internal forces.
Walking the Talk: Putting Constructivist Thinking into Practice in Classrooms.
ERIC Educational Resources Information Center
Riley, Maureen Keohane; And Others
1993-01-01
The constructivist approach of the Teacher as Composer project used analog experiences that replicate thinking and social demands. Classroom constraints, inservice limitations, and teacher mindsets impeded its application. Personal narratives and principles of children's thinking helped bridge the gap between theory and practice. (SK)
Bridging the gaps between scientific literature and grower perceptions of trunk disease management
USDA-ARS?s Scientific Manuscript database
Trunk diseases significantly limit the productivity of California vineyards. Field trials have shown three practices to minimize infection of pruning wounds: delayed pruning, double pruning, and the fungicide thiophanate-methyl (Topsin M). For optimal efficacy, such preventative practices must be a...
Opening Up Classroom Space: Student Voice, Autobiography, & the Curriculum
ERIC Educational Resources Information Center
Bernhardt, Philip
2009-01-01
Incorporating autobiography into the classroom has the potential to facilitate reflective and interpretative practices, through which self-understanding and transformative learning may emerge. Bridging theory, practice, and the personal, this paper explores how autobiographical narratives were incorporated into a 9th grade social studies class to…
Strategies for Developing Family Nursing Communities of Practice Through Social Media.
Isaacson, Kris; Looman, Wendy S
2017-02-01
This discussion article presents communities of practice (CoPs) and bridging social capital as conceptual frameworks to demonstrate how social media can be leveraged for family nursing knowledge, scholarship, and practice. CoPs require a shared domain of interest, exchange of resources, and dedication to expanding group knowledge. Used strategically and with a professional presence, mainstream social media channels such as Twitter, Facebook, and YouTube can support the family nurse in developing and contributing to CoPs related to family nursing. This article presents four strategies-curate, connect, collaborate, and contribute-for establishing and growing a social media presence that fits one's professional goals and time availability. Family nurses who leverage social media using these strategies can strengthen existing CoPs and at the same time bridge networks to reach new audiences, such as family advocacy groups, policy makers, educators, practitioners, and a wide array of other extended networks.
Folk, Johanna B.; Disabato, David J.; Goodman, Fallon R.; Carter, Sarah P.; DiMauro, Jennifer C.; Riskind, John H.
2017-01-01
Progress in clinical science, theory, and practice requires the integration of advances from multiple fields of psychology, but much integration remains to be done. The current article seeks to address the specific gap that exists between basic social psychological theories and the implementation of related therapeutic techniques. We propose several “wise additions,” based upon the principles outlined by Walton (2014), intended to bridge current social psychological research with clinical psychological therapeutic practice using cognitive behavioral therapy as an example. We consider how recent advances in social psychological theories can inform the development and implementation of wise additions in clinical case conceptualization and interventions. We specifically focus on self and identity, self-affirmation, transference, social identity, and embodied cognition, five dominant areas of interest in the field that have clear clinical applications. PMID:28919701
Enhancing the hermeneutic single-case efficacy design: Bridging the research-practice gap.
Wall, Jessie M; Kwee, Janelle L; Hu, Monica; McDonald, Marvin J
2017-09-01
Systematic case study designs are emerging as alternative paradigm strategies for psychotherapy and social science research. Through enhanced sensitivity to context, these designs examine idiographic profiles of causal processes. We specifically advocate the use of the hermeneutic single-case efficacy design (HSCED). HSCED has recently been used to investigate the efficacy of an existing therapy with a new population (Observed and Experiential Integration for athlete performance barriers) and an emerging therapy (Lifespan Integration Therapy). We describe innovations in HSCED that were implemented for these studies. These developments include (a) integrating psychotherapists as case developers, (b) incorporating multiple cases in one investigation, and (c) tailoring the repertoire of assessment tools. These extensions strategically incorporated principles of contextual paradigms in HSCED, thus complementing single-case designs that neglect idiographic contexts. We discuss recommendations for using HSCED in practice-based research, highlighting its potential as a bridge to address the research-practice gap.
ERIC Educational Resources Information Center
Rooney, Donna; Hopwood, Nick; Boud, David; Kelly, Michelle
2015-01-01
The preparation of future professionals for practice is a key focus of higher education institutions. Among a range of approaches is the use of simulation pedagogies. While simulation is often justified as a direct bridge between higher education and professional practice, this paper questions this easy assumption. It develops a conceptually…
ERIC Educational Resources Information Center
Matsuda, Aya, Ed.
2012-01-01
This book critically examines current ELT practices vis-a-vis the use of English as an international lingua franca. It bridges the gap between theoretical discussion and the practical concerns of teaching English as an international language (EIL), and presents diverse approaches for preparing competent users of English in international contexts.…
Celebrating Moderate Dualism in the Philosophy of Education: A Reflection on the Hirst-Carr Debate
ERIC Educational Resources Information Center
Noaparast, Khosrow Bagheri
2013-01-01
The position of the philosophy of education in theoretical or practical philosophy was the main subject of debate between Paul Hirst and Wilfred Carr. In his support for practical philosophy, Carr argues that in order to bridge the theory/practice gap and deconstruct the illusory intactness of philosophy of education from developments in the…
ERIC Educational Resources Information Center
Franks, Robert P.; Bory, Christopher T.
2015-01-01
Research on implementation science has increased significantly over the past decade. In particular, psychologists have looked closely at the value and importance of bridging the gap between science and practice. As evidence-based practices (EBPs) become more prevalent, concrete mechanisms are needed to bring these scientifically supported…
ERIC Educational Resources Information Center
Linehan, Patrice Cunniff
2010-01-01
This study examined how one state approached the integration of policy and practice by forming communities of practice (CoP), defined as groups of people who share a set of problems and interact regularly to solve them (Wenger, McDermott, & Snyder, 2002). Policymakers have created strategies known as technical assistance (TA) to bridge the…
Rapid multichannel impact-echo scanning of concrete bridge decks from a continuously moving platform
NASA Astrophysics Data System (ADS)
Mazzeo, Brian A.; Larsen, Jacob; McElderry, Joseph; Guthrie, W. Spencer
2017-02-01
Impact-echo testing is a non-destructive evaluation technique for determining the presence of defects in reinforced concrete bridge decks based on the acoustic response of the bridge deck when struck by an impactor. In this work, we build on our prior research with a single-channel impactor to demonstrate a seven-channel impact-echo scanning system with independent control of the impactors. This system is towed by a vehicle and integrated with distance measurement for registering the locations of the impacts along a bridge deck. The entire impact and recording system is computer-controlled. Because of a winch system and hinged frame construction of the apparatus, setup, measurement, and take-down of the apparatus can be achieved in a matter of minutes. Signal processing of the impact responses is performed on site and can produce a map of delaminations immediately after data acquisition. This map can then be used to guide other testing and/or can be referenced with the results of other testing techniques to facilitate comprehensive condition assessments of concrete bridge decks. This work demonstrates how impact-echo testing can be performed in a manner that makes complete bridge deck scanning for delaminations rapid and practical.
Numerical investigation into thermal load responses of steel railway bridge
NASA Astrophysics Data System (ADS)
Saravana Raja Mohan, K.; Sreemathy, J. R.; Saravanan, U.
2017-07-01
Bridge design requires consideration of the effects produced by temperature variations and the resultant thermal gradients in the structure. Temperature fluctuation leads to expansion and contraction of bridges and these movements are taken care by providing expansion joints and bearings. Free movements of a member can be restrained by imposing certain boundary condition but at the same time considerable allowances should be made for the stresses resulting from this restrained condition since the additional deformations and stresses produced may affect the ultimate and serviceability limit states of the structure. If the reaction force generated by the restraints is very large, then its omission can lead to unsafe design. The principal objective of this research is to study the effects of temperature variation on stresses and deflection in a steel railway bridge. A numerical model, based on finite element analysis is presented for evaluating the thermal performance of the bridge. The selected bridge is analyzed and the temperature field distribution and the corresponding thermal stresses and strains are calculated using the finite element software ABAQUS. A thorough understanding of the thermal load responses of a structure will result in safer and dependable design practices.
Nadyrov, Eldar; Rozhko, Alexander; Kravtsov, Viacheslav; Mabuchi, Kiyohiko; Hatch, Maureen; Nakamura, Nori; Nikonovich, Sergey; Aleksanin, Sergey
2012-05-01
The Belarus-American (BelAm) thyroid study cohort consists of persons who were 0-18 years of age at the time of exposure to radioactive iodine fallout from the 1986 Chernobyl nuclear power plant accident and who have undergone serial thyroid screenings with referral for fine-needle aspiration biopsy (FNAB) using standardized criteria. We investigated thyrocyte nuclear abnormalities in cytological samples from FNABs in 75 BelAm subjects with single and multiple thyroid nodules and 47 nodular goiter patients from Leningrad, Russia, unexposed to Chernobyl fallout. Nuclear abnormalities examined included internuclear chromosome bridges and derivative nuclei with broken bridges (i.e., "tailed" nuclei), which are formed from dicentric and ring chromosomes and thus may be cellular markers of radiation exposure. Among subjects with single-nodular goiter, thyrocytes with bridges were present in 86.8% of the exposed BelAm cohort compared with 27.0% of unexposed controls. The average frequency of thyrocytes with bridges and with tailed nuclei was also significantly higher in the BelAm subjects than in controls. Among subjects with multinodular goiters, thyrocytes with bridges were present in 75.7% of exposed BelAm patients compared with 16.7% of unexposed controls; thyrocytes with tailed nuclei were observed in all of the BelAm subjects but in only 40% of controls, and the mean frequencies of bridges and tailed nuclei were significantly higher in the exposed group. Unusually, long bridges were detected in 29% of BelAm patients with single-nodular goiters and 35% of those with multinodular goiters, while no such abnormalities were observed among patients from the Leningrad region. In the exposed subjects from BelAm, we also found positive correlations between their estimated dose of Iodine-131 from Chernobyl fallout and the frequency of tailed nuclei (p = 0.008) and bridges (p = 0.09). Further study is needed to confirm that these phenomena represent consequences of radiation exposure in the human organism.
Action Research as a Professional Development Activity
ERIC Educational Resources Information Center
West, Chad
2011-01-01
Reflective teachers are always searching for ways to improve their teaching. When this reflection becomes intentional and systematic, they are engaging in teacher research. This type of research, sometimes called "action research", can help bridge the gap between theory and practice by addressing topics that are relevant to practicing teachers.…
Integrating Science and Literacy Instruction: A Framework for Bridging the Gap
ERIC Educational Resources Information Center
Freeman, Gene; Taylor, Vickie
2006-01-01
There is vast research that substantiates the integration of science and literacy; however, there are very few books that correlate findings and address specific practices. "Integrating Science and Literary Instruction" connects scientifically based research and best instructional practices in literacy and integrates this with the inquiry-based…
Genomics Education in Practice: Evaluation of a Mobile Lab Design
ERIC Educational Resources Information Center
Van Mil, Marc H. W.; Boerwinkel, Dirk Jan; Buizer-Voskamp, Jacobine E.; Speksnijder, Annelies; Waarlo, Arend Jan
2010-01-01
Dutch genomics research centers have developed the "DNA labs on the road" to bridge the gap between modern genomics research practice and secondary-school curriculum in the Netherlands. These mobile DNA labs offer upper-secondary students the opportunity to experience genomics research through experiments with laboratory equipment that…
International Preschool Inclusion: Bridging the Gap between Vision and Practices
ERIC Educational Resources Information Center
Frankel, Elaine B.; Gold, Susan; Ajodhia-Andrews, Amanda
2010-01-01
Inclusion, promoted internationally by both legislative mandate and societal values, is a practice in which early childhood educators are encouraged to explore new methods for serving children with disabilities and developmental delays in typical early childhood programs. The belief that children with disabilities should participate within natural…
Appreciative Inquiry and Implementation Science in Leadership Development.
Bleich, Michael R; Hessler, Christine
2016-05-01
Appreciative inquiry was developed to initiate and animate change. As implementation science gains a foothold in practice settings to bridge theory, evidence, and practice, appreciative inquiry takes on new meaning as a leadership intervention and training tool. J Contin Educ Nurs. 2016;47(5):207-209. Copyright 2016, SLACK Incorporated.
Code of Federal Regulations, 2012 CFR
2012-07-01
... SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.230 Work practice standards for conducting lead-based paint activities: public... lead-based paint activities: public and commercial buildings, bridges and superstructures. [Reserved...
Code of Federal Regulations, 2013 CFR
2013-07-01
... SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.230 Work practice standards for conducting lead-based paint activities: public... lead-based paint activities: public and commercial buildings, bridges and superstructures. [Reserved...
Code of Federal Regulations, 2014 CFR
2014-07-01
... SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.230 Work practice standards for conducting lead-based paint activities: public... lead-based paint activities: public and commercial buildings, bridges and superstructures. [Reserved...
Bridging Divides through Technology Use: Transnationalism and Digital Literacy Socialization
ERIC Educational Resources Information Center
Nogueron, Silvia Cecilia
2011-01-01
In this study, I investigate the digital literacy practices of adult immigrants, and their relationship with transnational processes and practices. Specifically, I focus on their conditions of access to information and communication technologies (ICTs) in their life trajectories, their conditions of learning in a community center, and their…
Adolescents' Emerging Habitus: The Role of Early Parental Expectations and Practices
ERIC Educational Resources Information Center
Bodovski, Katerina
2014-01-01
This study makes two contributions to the literature. First, it bridges the sociological discussion of social class habitus with psychological notions of adolescents' educational expectations, locus of control, and self-concepts. Second, it empirically examines the relationships between early employed parental practices and expectations and…
Examining the Principal Preparation and Practice Gap
ERIC Educational Resources Information Center
Martin, Gary E.; Papa, Rosemary
2008-01-01
To anticipate the future needs of principal preparation, it is important to understand past efforts to bridge the preparation and practice gap. Decades ago, both the military and corporate industries discovered that classroom training was not meeting their needs for preparing soldiers and business professionals for real-life challenges. So they…
Deaf-Blind Perspectives. 1996-97.
ERIC Educational Resources Information Center
Deaf-Blind Perspectives, 1996
1996-01-01
Three issues of this newsletter include articles on and news items related to deaf-blindness. Articles include the following: "Research-to-Practice: Bridging the Gap between Research and Demonstration Projects and Practical Needs of Parents and Educators" (Harvey Mar and Nancy Sall); "Syndromes, Behavior, and Educational Intervention" (J. P. M.…
Assessment as Action Research: Bridging Academic Scholarship and Everyday Practice
ERIC Educational Resources Information Center
Malenfant, Kara J.; Hinchliffe, Lisa Janicke; Gilchrist, Debra
2016-01-01
This introductory essay to this special issue demonstrates that action research has a vital role in evidence-informed practice in academic libraries. This special issue of "College and Research Libraries" ("C&RL") proudly features a selection of action research studies by participants of the Association of College and…
JOSPT Experiences Tremendous Growth, Change in 14 Years With Editor-in-Chief Simoneau in Charge.
Nyland, John A
2015-12-01
As Editor-in-Chief, Dr Guy G. Simoneau and his editorial board have taken JOSPT from an acceptable US-based journal to a highly influential worldwide force behind contemporary orthopaedic and sports physical therapy research and practice. Today, the bridge Dr Simoneau constructed spans the orthopaedic and sports physical therapy globe for the betterment of clinical practice and research. His work fully supports JOSPT's latest strategic plan to provide value-added knowledge translation, develop a broader authorship and readership, increase global marketing of the JOSPT brand, and expand current relationships to new partners and stakeholders. The bridge places JOSPT on very firm footing, tying its rich history to the promise of an exciting and successful future.
Bridging graduate education in public health and the liberal arts.
Aelion, C Marjorie; Gubrium, Aline C; Aulino, Felicity; Krause, Elizabeth L; Leatherman, Thomas L
2015-03-01
The University of Massachusetts Amherst is part of Five-Colleges Inc, a consortium that includes the university and four liberal arts colleges. Consortium faculty from the School of Public Health and Health Sciences at the university and from the colleges are working to bridge liberal arts with public health graduate education. We outline four key themes guiding this effort and exemplary curricular tools for innovative community-based and multidisciplinary academic and research programs. The structure of the consortium has created a novel trajectory for student learning and engagement, with important ramifications for pedagogy and professional practice in public health. We show how graduate public health education and liberal arts can, and must, work in tandem to transform public health practice in the 21st century.
Seismic assessment of a multi-span steel railway bridge in Turkey based on nonlinear time history
NASA Astrophysics Data System (ADS)
Yılmaz, Mehmet F.; Çağlayan, Barlas Ö.
2018-01-01
Many research studies have shown that bridges are vulnerable to earthquakes, graphically confirmed by incidents such as the San Fernando (1971 USA), Northridge (1994 USA), Great Hanshin (1995 Japan), and Chi-Chi (1999 Taiwan) earthquakes, amongst many others. The studies show that fragility curves are useful tools for bridge seismic risk assessments, which can be generated empirically or analytically. Empirical fragility curves can be generated where damage reports from past earthquakes are available, but otherwise, analytical fragility curves can be generated from structural seismic response analysis. Earthquake damage data in Turkey are very limited, hence this study employed an analytical method to generate fragility curves for the Alasehir bridge. The Alasehir bridge is part of the Manisa-Uşak-Dumlupınar-Afyon railway line, which is very important for human and freight transportation, and since most of the country is seismically active, it is essential to assess the bridge's vulnerability. The bridge consists of six 30 m truss spans with a total span 189 m supported by 2 abutments and 5 truss piers, 12.5, 19, 26, 33, and 40 m. Sap2000 software was used to model the Alasehir bridge, which was refined using field measurements, and the effect of 60 selected real earthquake data analyzed using the refined model, considering material and geometry nonlinearity. Thus, the seismic behavior of Alasehir railway bridge was determined and truss pier reaction and displacements were used to determine its seismic performance. Different intensity measures were compared for efficiency, practicality, and sufficiency and their component and system fragility curves derived.
The effect of H2O on the adsorption of NO2 on γ-Al2O3: an in situ FTIR/MS study
DOE Office of Scientific and Technical Information (OSTI.GOV)
Szanyi, Janos; Kwak, Ja Hun; Chimentao, Ricardo J.
2007-02-15
The effect of water on the adsorption of NO2 onto a γ-Al2O3 catalyst support surface was investigated using Fourier transform infrared spectroscopy (FTIR) and mass spectrometry (MS). Upon room temperature exposure of the alumina surface to small amounts of NO2, nitrites and nitrates are formed, and at higher NO2 doses only nitrates are observed. The surface nitrates formed were of bridging monodentate, bridging bidentate, and monodentate configuration. At elevated NO2 pressures, the surface hydroxyls were consumed in their reaction with NO2 giving primarily bridge-bound nitrates. A significant amount of weakly adsorbed N2O3 was seen as well. Exposure of the NO2-saturatedmore » γ-Al2O3 surface to H2O resulted in the desorption of some NO2 + NO as H2O interacted with the weakly-held N2O3, while the bridging monodentate surface nitrates converted into monodentate nitrates. The conversion of these oxide-bound nitrates to water-solvated nitrates was observed at high water doses when the presence of liquid-like water is expected on the surface. The addition of H2O to the NO2-saturated γ-Al2O3 did not affect the amount of NOx strongly adsorbed on the support surface. In particular, no NOx desorption was observed when the NO2-saturated sample was heated to 573K prior to room temperature H2O exposure. The effect of water is completely reversible; i.e., during TPD experiments following NO2 and H2O coadsorption, the same IR spectra were observed at temperatures above that required for H2O desorption as seen for NO2 adsorption only experiments.« less
ERIC Educational Resources Information Center
O'Brien, David J.; Garland, T. Neal
Two major gaps have long existed in family studies: first, the gap between theory and research, and second, the gap between scientific research and its application to practice and policy issues. While the four issues of theory, research, practice, and policy-making are often dealt with separately, the four must become closely integrated if real…
ERIC Educational Resources Information Center
Kinghorn, Brian Edward
2013-01-01
Subject-specific content knowledge is crucial for effective science teaching, yet many teachers are entering the field not fully equipped with all the science content knowledge they need to effectively teach the subject. Learning from practice is one approach to bridging the gap between what practicing teachers know and what they need to know.…
ERIC Educational Resources Information Center
Tan, Jennifer Poh Sim
2015-01-01
Research has consistently shown that children in residential care fall behind at school. This proves a great challenge for educators who have to cater to the students' needs to ensure no one is left behind. Studies investigating family literacy practices of different social classes show a positive implication if the home literacy practices are…
Radiation Effects on DC-DC Converters
NASA Technical Reports Server (NTRS)
Zhang, De-Xin; AbdulMazid, M. D.; Attia, John O.; Kankam, Mark D. (Technical Monitor)
2001-01-01
In this work, several DC-DC converters were designed and built. The converters are Buck Buck-Boost, Cuk, Flyback, and full-bridge zero-voltage switched. The total ionizing dose radiation and single event effects on the converters were investigated. The experimental results for the TID effects tests show that the voltages of the Buck Buck-Boost, Cuk, and Flyback converters increase as total dose increased when using power MOSFET IRF250 as a switching transistor. The change in output voltage with total dose is highest for the Buck converter and the lowest for Flyback converter. The trend of increase in output voltages with total dose in the present work agrees with those of the literature. The trends of the experimental results also agree with those obtained from PSPICE simulation. For the full-bridge zero-voltage switch converter, it was observed that the dc-dc converter with IRF250 power MOSFET did not show a significant change of output voltage with total dose. In addition, for the dc-dc converter with FSF254R4 radiation-hardened power MOSFET, the output voltage did not change significantly with total dose. The experimental results were confirmed by PSPICE simulation that showed that FB-ZVS converter with IRF250 power MOSFET's was not affected with the increase in total ionizing dose. Single Event Effects (SEE) radiation tests were performed on FB-ZVS converters. It was observed that the FB-ZVS converter with the IRF250 power MOSFET, when the device was irradiated with Krypton ion with ion-energy of 150 MeV and LET of 41.3 MeV-square cm/mg, the output voltage increased with the increase in fluence. However, for Krypton with ion-energy of 600 MeV and LET of 33.65 MeV-square cm/mg, and two out of four transistors of the converter were permanently damaged. The dc-dc converter with FSF254R4 radiation hardened power MOSFET's did not show significant change at the output voltage with fluence while being irradiated by Krypton with ion energy of 1.20 GeV and LET of 25.97 MeV-square cm/mg. This might be due to fact that the device is radiation hardened.
Jones, Fiona; Pöstges, Heide; Brimicombe, Lucinda
2016-10-14
Programmes providing self-management support for patients and families are gaining attention and have shown promising outcomes with regards to reducing long-term unmet needs post stroke. However, notions of what good self-management support looks like can differ depending on professional opinion, individual preferences, skills and experiences of patients and their families as well as on how care and rehabilitation is organised in a particular healthcare setting. This resonates with the perspective of patient-centred care, according to which the meaning of good care is not universal, but rather jointly shaped between healthcare professionals and patients in everyday interactions. While self-management support is continuously co-produced in care and rehabilitation practices, most self-management programmes are typically provided as an 'add-on' to existing statutory care. This paper aims to deepen the understanding of how self-management support can be made an integral part of everyday care and rehabilitation using Bridges methodology. The authors provide a self-reflective account on 'Bridges' an integrated approach to self-management support, which is used by healthcare professionals within acute and community stroke rehabilitation across the UK, and in some parts of New Zealand and Australia. Bridges is based on self-efficacy principles, but has a central aim of professionals sharing decision-making and expertise with patients and families in every healthcare interaction. Methodologically, the co-production of a Bridges support package with local healthcare professionals and patients is critical. The authors present the values articulated by the support package and how it engages professionals, patients and Bridges training facilitators in a continuous process of adjusting and re-adjusting situated self-management support practices. Our reflections reveal the need to consider development and implementation of self-management support as one and the same on-going process, if we are to facilitate successful engagement and interest from healthcare professionals as well as their patients and families.
Applications of infrared thermography for nondestructive testing of fatigue cracks in steel bridges
NASA Astrophysics Data System (ADS)
Sakagami, Takahide; Izumi, Yui; Kobayashi, Yoshihiro; Mizokami, Yoshiaki; Kawabata, Sunao
2014-05-01
In recent years, fatigue crack propagations in aged steel bridge which may lead to catastrophic structural failures have become a serious problem. For large-scale steel structures such as orthotropic steel decks in highway bridges, nondestructive inspection of deteriorations and fatigue damages are indispensable for securing their safety and for estimating their remaining strength. As conventional NDT techniques for steel bridges, visual testing, magnetic particle testing and ultrasonic testing have been commonly employed. However, these techniques are time- and labor- consuming techniques, because special equipment is required for inspection, such as scaffolding or a truck mount aerial work platform. In this paper, a new thermography NDT technique, which is based on temperature gap appeared on the surface of structural members due to thermal insulation effect of the crack, is developed for detection of fatigue cracks. The practicability of the developed technique is demonstrated by the field experiments for highway steel bridges in service. Detectable crack size and factors such as measurement time, season or spatial resolution which influence crack detectability are investigated.
A Translational Model of Research-Practice Integration
Vivian, Dina; Hershenberg, Rachel; Teachman, Bethany A.; Drabick, Deborah A. G.; Goldfried, Marvin R.; Wolfe, Barry
2013-01-01
We propose a four-level, recursive Research-Practice Integration framework as a heuristic to (a) integrate and reflect on the articles in this Special Section as contributing to a bidirectional bridge between research and practice, and (b) consider additional opportunities to address the research–practice gap. Level 1 addresses Treatment Validation studies and includes an article by Lochman and colleagues concerning the programmatic adaptation, implementation, and dissemination of the empirically supported Coping Power treatment program for youth aggression. Level 2 translation, Training in Evidence-Based Practice, includes a paper by Hershenberg, Drabick, and Vivian, which focuses on the critical role that predoctoral training plays in bridging the research–practice gap. Level 3 addresses the Assessment of Clinical Utility and Feedback to Research aspects of translation. The articles by Lambert and Youn, Kraus, and Castonguay illustrate the use of commercial outcome packages that enable psychotherapists to integrate ongoing client assessment, thus enhancing the effectiveness of treatment implementation and providing data that can be fed back to researchers. Lastly, Level 4 translation, the Cross-Level Integrative Research and Communication, concerns research efforts that integrate data from clinical practice and all other levels of translation, as well as communication efforts among all stakeholders, such as researchers, psychotherapists, and clients. Using a two-chair technique as a framework for his discussion, Wolfe's article depicts the struggle inherent in research–practice integration efforts and proposes a rapprochement that highlights advancements in the field. PMID:22642522
NASA Astrophysics Data System (ADS)
Lin, YuanFang; Zheng, XiaoDong; Huang, YuJia
2017-08-01
Curriculum design and simulation courses are bridges to connect specialty theories, engineering practice and experimental skills. In order to help students to have the computer aided optical system design ability adapting to developments of the times, a professional optical software-Advanced System of Analysis Program (ASAP) was used in the research teaching of curriculum design and simulation courses. The ASAP tutorials conducting, exercises both complementing and supplementing the lectures, hands-on practice in class, autonomous learning and independent design after class were bridged organically, to guide students "learning while doing, learning by doing", paying more attention to the process instead of the results. Several years of teaching practice of curriculum design and simulation courses shows that, project-based learning meets society needs of training personnel with knowledge, ability and quality. Students have obtained not only skills of using professional software, but also skills of finding and proposing questions in engineering practice, the scientific method of analyzing and solving questions with specialty knowledge, in addition, autonomous learning ability, teamwork spirit and innovation consciousness, still scientific attitude of facing failure and scientific spirit of admitting deficiency in the process of independent design and exploration.
Upper Secondary Chemistry Students in a Pharmacochemistry Research Community
NASA Astrophysics Data System (ADS)
van Rens, Lisette; van Muijlwijk, Jacqueline; Beishuizen, Jos; van der Schee, Joop
2013-04-01
This study deals with the participation of 10 upper secondary chemistry students, aged 16-17, and their chemistry teacher in a pharmacochemistry research community on anti-allergy medicines at VU University, Amsterdam, The Netherlands. Participation of students in scientific research raises the question of how to bridge the gap between an upper secondary school inquiry practice and a scientific research practice. To bridge this gap, a design based on 6 principles derived from an educational model of a community of learners was proposed. The study first aimed at revealing whether the proposed principles were necessary according to the students, their teacher and three pharmacochemistry researchers for successful participation of the students in the research community. Second, the study examined whether the students' understanding of discipline-specific content knowledge, interest in scientific research and knowledge about the nature of science changed during the course of the study. Data were obtained from questionnaires, interviews and video tapes. The results indicated that according to the teacher all 6 principles were necessary to bridge the gap, whereas according to the students 1 principle and according to the pharmacochemistry researchers 2 principles were necessary but difficult to achieve. Furthermore, all students gained discipline-specific content knowledge. Their interest in scientific research exhibited a positive change and their knowledge about the nature of science increased. The implications for further research and practice are discussed.
I Make a Difference: Making the Transition from Clinician to Educator!
ERIC Educational Resources Information Center
Hudson, Larry, Ed.; And Others
Intended for the vocational health occupations (VHO) teacher during the transition from clinician to teacher, this practical handbook offers advice on bridging the gap between practice and teaching. Chapter 1 addresses defining one's new role. Chapter 2 on classroom instruction looks at student motivation, teaching techniques, student feedback,…
Professional Learning Communities: Teachers Working Collaboratively for Continuous Improvement
ERIC Educational Resources Information Center
Griffith, Louise Ann
2009-01-01
Current research indicates that a professional learning community (PLC) is an effective means for helping teachers to bridge the gap between research and practice. A PLC is a team of educators systematically working together to improve teaching practice and student learning. This study evaluated the PLC formed by teachers at a public elementary…
The First R: Every Child's Right to Read. (Language and Literacy Series).
ERIC Educational Resources Information Center
Graves, Michael F., Ed.; And Others
This book suggests that learning to read should be a right for all children. From this viewpoint, the book constructs a bridge between current knowledge of reading processes and educational practice by incorporating a comprehensive range of theory, practice, and research, and a solid foundation in education and psychological science. Topics…
ERIC Educational Resources Information Center
Corlett, Jo; Palfreyman, J. W.; Staines, H. J.; Marr, H.
2003-01-01
The effect of the following on bridging the theory-practice gap in nursing education was examined: (1) theory taught by preceptors or nurse educators; (2) nurse educator/preceptor collaboration on content; and (3) immediate clinical placements following theory learning. Preceptors were more effective, collaboration was ineffective, and delay was…
Bridging the University School-Divide: Horizontal Expertise and the "Two-Worlds Pitfall"
ERIC Educational Resources Information Center
Anagnostopoulos, Dorothea; Smith, Emily R.; Basmadjian, Kevin G.
2007-01-01
Research on teacher learning consistently documents the disjuncture between the practices beginning teachers encounter in university teacher preparation courses and those they reencounter in the K-12 classrooms in which they learn to teach. As preservice teachers enter teaching, they gravitate toward conventional K-12 practices, dismissing those…
Teachers' Identity, Self and the Process of Learning
ERIC Educational Resources Information Center
Hoveid, Halvor; Hoveid, Marit Honerod
2008-01-01
In this paper we try, by drawing on some insights from practical knowledge, to bridge a gap between common conceptions of teaching on the one hand, and of learning on the other. In Western traditions of educational thought and discourse, practical knowledge--i.e. the dynamics of thinking, speaking, acting, and personal writing--is frequently…
The Challenge of Educating Principals: Linking Course Content to Action
ERIC Educational Resources Information Center
Ärlestig, Helene
2012-01-01
Effective integration of learning and practice continues to remain a challenge in leadership preparation. This paper describes a learning module used in a course within the Swedish National Principal Training Program and how it attempts to bridge learning with practice. In this course, each participant conducted a study in a school with the…
Implementation Science: Why It Matters for the Future of Social Work
ERIC Educational Resources Information Center
Cabassa, Leopoldo J.
2016-01-01
Bridging the gap between research and practice is a critical frontier for the future of social work. Integrating implementation science into social work can advance our profession's effort to bring research and practice closer together. Implementation science examines the factors, processes, and strategies that influence the uptake, use, and…
ERIC Educational Resources Information Center
Phillips, Christopher M.
2011-01-01
Statement of the problem. Appalachian community colleges are dealing with a dynamic transfer policy environment and implementing practices that either foster or impede transfer student success. The problem in this dissertation is to discern how Appalachian community colleges are making sense of transfer policy changes and conducting practices to…
The Live Teaching Case: A New IS Method and Its Application
ERIC Educational Resources Information Center
Cameron, Ann-Frances; Trudel, Marie-Claude; Titah, Ryad; Leger, Pierre-Majorique
2012-01-01
When teaching Information Systems (IS), one of the crucial objectives is to make students understand the practical aspects of the integration of IS in organizations. Over the last decades, several pedagogical approaches were introduced to more tightly bridge theory and practice, e.g., hands on exercises, simulations, real world projects, guest…
Building Bridges: Using the Office Consultation Project to Connect Students to Theory and Practice
ERIC Educational Resources Information Center
Wawrzynski, Korine Steinke; Jessup-Anger, Jody E.
2014-01-01
The Office Consultation Project is an innovative capstone project that partners graduate students in student affairs preparation programs with academic and student affairs practitioners. It provides an opportunity for students to apply research and scholarship to practical settings, while giving practitioners new insight into their units,…
ERIC Educational Resources Information Center
Koedinger, Kenneth R.; Corbett, Albert T.; Perfetti, Charles
2012-01-01
Despite the accumulation of substantial cognitive science research relevant to education, there remains confusion and controversy in the application of research to educational practice. In support of a more systematic approach, we describe the Knowledge-Learning-Instruction (KLI) framework. KLI promotes the emergence of instructional principles of…
A Community College and Employer Partnership. Promising Practice
ERIC Educational Resources Information Center
Office of Community College Research and Leadership, 2010
2010-01-01
As a pilot site selected to participate in Illinois' Shifting Gears (SG) initiative in 2007, Oakton Community College (OCC) partnered with Presbyterian Homes to develop a bridge course to prepare a cadre of their employed Certified Nurse Assistants (CNAs) to enter college-credit level prerequisite courses to a Practical Nursing program. Oakton…
Consumer product categorizations in models of near-field (residential) exposures to must provide a bridge between habits and practices information (Why is the product used? Who uses the product? How much do they use? How often do they use it?) and product ingredients (What chemic...
Vibration-based monitoring for performance evaluation of flexible civil structures in Japan.
Fujino, Yozo
2018-01-01
The vibration-based monitoring of flexible civil structures and performance evaluation from this monitoring are reviewed, with an emphasis on research and practice in Japan and the author's experiences. Some new findings and unexpected vibrations from the monitoring of real bridges and buildings are reported to emphasize the importance of monitoring. Future developments and applications of vibration-based monitoring to civil infrastructure management are also described. Many examples are taken from the author's past 30 years' experience of research on bridge dynamics.
12. Photographic copy of photograph. (Source: U.S. Department of Interior. ...
12. Photographic copy of photograph. (Source: U.S. Department of Interior. Office of Indian Affairs. Indian Irrigation Service. Annual Report, Fiscal Year 1925. Vol. I, Narrative and Photographs, Irrigation District #4, California and Southern Arizona, RG 75, Entry 655, Box 28, National Archives, Washington, DC.) Photographer unknown. SACATON DAM AND BRIDGE FROM QUARRY HILL, PRACTICALLY COMPLETED, 6/18/25 - San Carlos Irrigation Project, Sacaton Dam & Bridge, Gila River, T4S R6E S12/13, Coolidge, Pinal County, AZ
The Red Book and clinical practice.
Bygott, Catherine
2012-09-01
Jung's work is fundamentally an experience, not an idea. From this perspective, I attempt to bridge conference, consulting room and living psyche by considering the influence of the 'Red Book' on clinical practice through the subtle and imaginal. Jung's journey as a man broadens out to have relevance for women. His story is individual but its archetypal foundation finds parallel expression in analytic practice today. © 2012, The Society of Analytical Psychology.
ERIC Educational Resources Information Center
Sembiante, Sabrina F.
2013-01-01
This qualitative case study examines the nature of a dual language preschool teacher's instructional practices and extratextual talk during shared-book reading practices with two different genres of books in Spanish and English. Specifically, I explore the interpersonal, ideational, and textual features of one teacher's talk in English- and…
... Kim DK, Riley LE, Harriman KH, Hunter P, Bridges CB. Advisory Committee on Immunization Practices recommended immunization ... commercial use must be authorized in writing by ADAM Health Solutions. About MedlinePlus Site Map FAQs Customer ...
Nalder, Emily Joan; Putnam, Michelle; Salvador-Carulla, Luis; Spindel, Andria; Batliwalla, Zinnia; Lenton, Erica
2017-10-25
Bridging is a term used to describe activities, or tasks, used to promote collaboration and knowledge exchange across fields. This paper reports the protocol for a scoping review which aims to identify and characterise peer reviewed evidence describing bridging activities, between the ageing and disability fields. The purpose is to clarify the concepts underpinning bridging to inform the development of a taxonomy, and identify research strengths and gaps. A scoping review will be conducted. We will search Medline, Cumulative Index to Nursing and Allied Health Literature, Embase, PsycInfo, Sociological Abstracts and the Cochrane Library, to identify peer reviewed publications (reviews, experimental, observational, qualitative designs and expert commentaries) describing bridging activities. Grey literature, and articles not published in English will be excluded. Two investigators will independently complete article selection and data abstraction to minimise bias. A data extraction form will be iteratively developed and information from each publication will be extracted: (1) bibliographic, (2) methodological, (3) demographic, and (4) bridging information. Qualitative content analysis will be used to describe key concepts related to bridging. To our knowledge, this will be the first scoping review to describe bridging of ageing and disability knowledge, services and policies. The findings will inform the development of a taxonomy to define models of bridging that can be implemented and further evaluated to enable integrated care and improve systems and services for those ageing with disability. Ethics is not required because this is a scoping review of published literature. Findings will be disseminated through stakeholder meetings, conference presentations and peer reviewed publication. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Hoetzenecker, Konrad; Donahoe, Laura; Yeung, Jonathan C; Azad, Sassan; Fan, Eddy; Ferguson, Niall D; Del Sorbo, Lorenzo; de Perrot, Marc; Pierre, Andrew; Yasufuku, Kazuhiro; Singer, Lianne; Waddell, Thomas K; Keshavjee, Shaf; Cypel, Marcelo
2018-03-01
Extracorporeal life support (ECLS) is increasingly used to bridge deteriorating patients awaiting lung transplantation (LTx), however, few systematic descriptions of this practice exist. We therefore aimed to review our institutional experience over the past 10 years. In this case series, we included all adults who received ECLS with the intent to bridge to LTx. Data were retrieved from patient charts and our institutional ECLS and transplant databases. Between January 2006 and September 2016, 1111 LTx were performed in our institution. ECLS was used in 71 adults with the intention to bridge to LTx; of these, 11 (16%) were bridged to retransplantation. The median duration of ECLS before LTx was 10 days (range, 0-95). We used a single dual-lumen venous cannula in 23 patients (32%). Nine of 13 patients (69%) with pulmonary hypertension were bridged by central pulmonary artery to left atrium Novalung. Twenty-five patients (35%) were extubated while on ECLS and 26 patients (37%) were mobilized. Sixty-three patients (89%) survived to LTx. Survival by intention to treat was 66% (1 year), 58% (3 years) and 48% (5 years). Survival was significantly shorter in patients undergoing ECLS bridge to retransplantation compared with first LTx (median survival, 15 months (95% CI, 0-31) versus 60 months (95% CI, 37-83); P = .041). In our center experience, ECLS bridge to first lung transplant leads to good short-term and long-term outcomes in carefully selected patients. In contrast, our data suggest that ECLS as a bridge to retransplantation should be used with caution. Copyright © 2017 The American Association for Thoracic Surgery. All rights reserved.
NASA Astrophysics Data System (ADS)
Yudono, Adipandang
2018-05-01
This research has attempted to discover a new approach in magnifying democracy and sovereignty in the Indonesian maritime governance through open marine spatial data practices between governments and citizens. The research has been done in order to fill in the gap of bridging marine spatial data or information at all government levels and between citizen and government. The research predominantly used qualitative methods with specifically approach was discourse analysis using legal document analysis and in-depth interview to elites, and local digital mapping communities. The coherence and synergy of maritime development can be achieved through dialogue between the elites and the public. A solution to bridge political communication between the elite and the public is sharing or open marine spatial data and information.
Bridging Graduate Education in Public Health and the Liberal Arts
Gubrium, Aline C.; Aulino, Felicity; Krause, Elizabeth L.; Leatherman, Thomas L.
2015-01-01
The University of Massachusetts Amherst is part of Five-Colleges Inc, a consortium that includes the university and four liberal arts colleges. Consortium faculty from the School of Public Health and Health Sciences at the university and from the colleges are working to bridge liberal arts with public health graduate education. We outline four key themes guiding this effort and exemplary curricular tools for innovative community-based and multidisciplinary academic and research programs. The structure of the consortium has created a novel trajectory for student learning and engagement, with important ramifications for pedagogy and professional practice in public health. We show how graduate public health education and liberal arts can, and must, work in tandem to transform public health practice in the 21st century. PMID:25706025
Practical applications of current loop signal conditioning
NASA Astrophysics Data System (ADS)
Anderson, Karl F.
1994-10-01
This paper describes a variety of practical application circuits based on the current loop signal conditioning paradigm. Equations defining the circuit response are also provided. The constant current loop is a fundamental signal conditioning circuit concept that can be implemented in a variety of configurations for resistance-based transducers, such as strain gages and resistance temperature devices. The circuit features signal conditioning outputs which are unaffected by extremely large variations in lead wire resistance, direct current frequency response, and inherent linearity with respect to resistance change. Sensitivity of this circuit is double that of a Wheatstone bridge circuit. Electrical output is zero for resistance change equals zero. The same excitation and output sense wires can serve multiple transducers. More application arrangements are possible with constant current loop signal conditioning than with the Wheatstone bridge.
Current loop signal conditioning: Practical applications
NASA Technical Reports Server (NTRS)
Anderson, Karl F.
1995-01-01
This paper describes a variety of practical application circuits based on the current loop signal conditioning paradigm. Equations defining the circuit response are also provided. The constant current loop is a fundamental signal conditioning circuit concept that can be implemented in a variety of configurations for resistance-based transducers, such as strain gages and resistance temperature detectors. The circuit features signal conditioning outputs which are unaffected by extremely large variations in lead wire resistance, direct current frequency response, and inherent linearity with respect to resistance change. Sensitivity of this circuit is double that of a Wheatstone bridge circuit. Electrical output is zero for resistance change equals zero. The same excitation and output sense wires can serve multiple transducers. More application arrangements are possible with constant current loop signal conditioning than with the Wheatstone bridge.
Hammerstingl, Christoph; Omran, Heyder; Tripp, Christian; Poetzsch, Bernd
2009-02-01
Low-molecular-weight heparins (LMWH) are commonly used as peri-procedural bridging anticoagulants. The usefulness of measurement of anti-factor Xa activity (anti-Xa) to guide bridging therapy with LMWH is unknown. It was the objective of this study to determine levels of anti-Xa during standard bridging therapy with enoxaparin, and to examine predictors for residual anti-Xa. Consecutive patients receiving enoxaparin at a dosage of 1 mg/kg body weight/12 hours for temporary interruption of phenprocoumon were prospectively enrolled to the study. Blood-samples were obtained 14 hours after LMWH-application immediately pre- procedurally. Procedural details, clinical and demographic data were collected and subsequently analyzed. Seventy patients were included (age 75.2 +/- 10.8 years, Cr Cl 55.7 +/- 21.7ml/min, body mass index [BMI] 27.1 +/- 4.9). LMWH- therapy was for a mean of 4.2 +/- 1.6 days; overall anti-Xa was 0.58 +/- 0.32 U/ml. In 37 (52.8%) of patients anti-Xa was > or U/ml, including 10 (14.3%) patients with anti-Xa > 1U/ml. Linear regression analysis of single variables and logistic multivariable regression analysis failed to prove a correlation between anti-Xa and single or combined factors. No major bleeding, no thromboembolism and four (5.7%) minor haemorrhages were observed. When bridging OAC with therapeutic doses of enoxaparin a high percentage of patients undergo interventions with high residual anti-Xa. The levels of anti-Xa vary largely and are independent of single or combined clinical variables. Since the anti-Xa-related outcome of patients receiving bridging therapy with LMWH is not investigated, no firm recommendation on the usefulness of monitoring of anti-Xa can be given at this stage.
Perkins, Danielle E K
2010-01-01
Newly graduated registered nurses face a barrage of physical and mental challenges in their first few years of practice, especially in the hospital setting. This article explores discrepancies between student nurse practice and professional nursing practice and the challenges that new nurses face in bridging the gap between idealistic theory and realistic practice. The author's subsequent graduate nursing education and continued practice in the field resulted in a personal evolution of practice that elicited a profound sense of appreciation for the field and a desire to share these experiences with other practicing nurses and students.
NASA Astrophysics Data System (ADS)
Bae, Won-Gyu; Kim, Doogon; Suh, Kahp-Yang
2013-11-01
Inspired by the exceptional climbing ability of gecko lizards, artificial fibrillar adhesives have been extensively studied over the last decade both experimentally and theoretically. Therefore, a new leap towards practical uses beyond the academic horizon is timely and highly anticipated. To this end, we present a fibrillar adhesive in the form of bridged micropillars and its application to a transportation system with the detachment mechanism inspired by the climbing behaviour of gecko lizards. The adhesive shows strong normal attachment (~30 N cm-2) as well as easy and fast detachment within 0.5 s without involving complex dynamic mechanisms or specific stimulus-responsive materials. The fabrication of the bridged micropillars consists of replica moulding of polydimethylsiloxane (PDMS) micropillars, transfer of the PDMS precursor to the heads of the micropillars, and inverse placement on an inert Teflon-coated surface. Owing to the spontaneous interconnections of low viscosity PDMS precursor, bridged micropillars with a uniform capping nanomembrane (~800 nm thickness) are formed over a large area. Interestingly, macroscopic adhesion in the normal direction can be immediately switched between on and off states by changing the two detachment modes of pulling and peeling, respectively. To prove the potential of the fibrillar adhesive for practical use, an automated transportation system is demonstrated for lifting and releasing a mass of stacked glass slides over 1000 cycles of attachment and detachment.Inspired by the exceptional climbing ability of gecko lizards, artificial fibrillar adhesives have been extensively studied over the last decade both experimentally and theoretically. Therefore, a new leap towards practical uses beyond the academic horizon is timely and highly anticipated. To this end, we present a fibrillar adhesive in the form of bridged micropillars and its application to a transportation system with the detachment mechanism inspired by the climbing behaviour of gecko lizards. The adhesive shows strong normal attachment (~30 N cm-2) as well as easy and fast detachment within 0.5 s without involving complex dynamic mechanisms or specific stimulus-responsive materials. The fabrication of the bridged micropillars consists of replica moulding of polydimethylsiloxane (PDMS) micropillars, transfer of the PDMS precursor to the heads of the micropillars, and inverse placement on an inert Teflon-coated surface. Owing to the spontaneous interconnections of low viscosity PDMS precursor, bridged micropillars with a uniform capping nanomembrane (~800 nm thickness) are formed over a large area. Interestingly, macroscopic adhesion in the normal direction can be immediately switched between on and off states by changing the two detachment modes of pulling and peeling, respectively. To prove the potential of the fibrillar adhesive for practical use, an automated transportation system is demonstrated for lifting and releasing a mass of stacked glass slides over 1000 cycles of attachment and detachment. Electronic supplementary information (ESI) available: Photograph of a custom-built adhesion measurement system, video snapshots showing the switchable adhesion via gecko-inspired detachment mechanism, schematic of fabricating a master mould, and a SEM image showing the thickness of the nanomembrane. See DOI: 10.1039/c3nr02008h
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.
Wagner, Steven L; Rynearson, Kevin D; Duddy, Steven K; Zhang, Can; Nguyen, Phuong D; Becker, Ann; Vo, Uyen; Masliah, Deborah; Monte, Louise; Klee, Justin B; Echmalian, Corinne M; Xia, Weiming; Quinti, Luisa; Johnson, Graham; Lin, Jiunn H; Kim, Doo Y; Mobley, William C; Rissman, Robert A; Tanzi, Rudolph E
2017-07-01
Alzheimer's disease (AD) is characterized neuropathologically by an abundance of 1) neuritic plaques, which are primarily composed of a fibrillar 42-amino-acid amyloid- β peptide (A β ), as well as 2) neurofibrillary tangles composed of aggregates of hyperphosporylated tau. Elevations in the concentrations of the A β 42 peptide in the brain, as a result of either increased production or decreased clearance, are postulated to initiate and drive the AD pathologic process. We initially introduced a novel class of bridged aromatics referred t γ -secretase modulatoro as γ -secretase modulators that inhibited the production of the A β 42 peptide and to a lesser degree the A β 40 peptide while concomitantly increasing the production of the carboxyl-truncated A β 38 and A β 37 peptides. These modulators potently lower A β 42 levels without inhibiting the γ -secretase-mediated proteolysis of Notch or causing accumulation of carboxyl-terminal fragments of APP. In this study, we report a large number of pharmacological studies and early assessment of toxicology characterizing a highly potent γ -secretase modulator (GSM), ( S )- N -(1-(4-fluorophenyl)ethyl)-6-(6-methoxy-5-(4-methyl-1 H -imidazol-1-yl)pyridin-2-yl)-4-methylpyridazin-3-amine (BPN-15606). BPN-15606 displayed the ability to significantly lower A β 42 levels in the central nervous system of rats and mice at doses as low as 5-10 mg/kg, significantly reduce A β neuritic plaque load in an AD transgenic mouse model, and significantly reduce levels of insoluble A β 42 and pThr181 tau in a three-dimensional human neural cell culture model. Results from repeat-dose toxicity studies in rats and dose escalation/repeat-dose toxicity studies in nonhuman primates have designated this GSM for 28-day Investigational New Drug-enabling good laboratory practice studies and positioned it as a candidate for human clinical trials. Copyright © 2017 by The Author(s).
Using business analytics to improve outcomes.
Rivera, Jose; Delaney, Stephen
2015-02-01
Orlando Health has brought its hospital and physician practice revenue cycle systems into better balance using four sets of customized analytics: Physician performance analytics gauge the total net revenue for every employed physician. Patient-pay analytics provide financial risk scores for all patients on both the hospital and physician practice sides. Revenue management analytics bridge the gap between the back-end central business office and front-end physician practice managers and administrators. Enterprise management analytics allow the hospitals and physician practices to share important information about common patients.
The Albert Einstein Distinguished Educator Fellowship: Bridging the Gap Between Policy and Practice
NASA Astrophysics Data System (ADS)
Milbourne, Jeff; Wheeler, Sam
2017-02-01
In an ideal world, education policy and practice would exist as parts of a coherent system. Effective practice would inform policy and that policy would, in turn, promote the tenets of effective practice at the local, state, and national levels. Policymakers and practitioners would collaborate and, by extension, have familiarity and respect for one another's perspective. Unfortunately, our current education system is a far cry from the ideal, a fact that we as practitioners know all too well.
Non-destructive inspection protocol for reinforced concrete barriers and bridge railings
NASA Astrophysics Data System (ADS)
Chintakunta, Satish R.; Boone, Shane D.
2014-02-01
Reinforced concrete highway barriers and bridge railings serve to prevent errant vehicles from departing the travel way at grade separations. Despite the important role that they play in maintaining safety and their ubiquitous nature, barrier inspection rarely moves beyond visual inspection. In August 2008, a tractor-trailer fatally departed William Preston Lane, Jr. Memorial Bridge after it dislodged a section of the bridge barrier. Investigations following the accident identified significant corrosion of the anchor bolts attaching the bridge railing to the bridge deck. As a result of the information gathered during its investigation of the accident, the National Transportation Safety Board (NTSB) made recommendations to the Federal Highway Administration concerning Non-Destructive Evaluation (NDE) of concrete bridge railings. The Center for nondestructive evaluation (NDE) at Turner Fairbank Highway Research Center in McLean, VA is currently evaluating feasibility of using four technologies - ground penetrating radar (GPR), ultrasonic pulse-echo, digital radiography and infrared thermal imaging methods to develop bridge inspection methods that augment visual inspections, offer reliable measurement techniques, and are practical, both in terms of time and cost, for field inspection work. Controlled samples containing predefined corrosion levels in reinforcing steel were embedded at barrier connection points for laboratory testing. All four NDE techniques were used in the initial phase I testing. An inspection protocol for detecting and measuring the corrosion of reinforced steel embedded in the anchorage system will be developed as part of phase II research. The identified technologies shall be further developed for field testing utilizing a structure with a barrier in good condition and a structure with a barrier in poor condition.
A statistical mechanics approach to autopoietic immune networks
NASA Astrophysics Data System (ADS)
Barra, Adriano; Agliari, Elena
2010-07-01
In this work we aim to bridge theoretical immunology and disordered statistical mechanics. We introduce a model for the behavior of B-cells which naturally merges the clonal selection theory and the autopoietic network theory as a whole. From the analysis of its features we recover several basic phenomena such as low-dose tolerance, dynamical memory of antigens and self/non-self discrimination.
Phlebotomy, a bridge between laboratory and patient
Ialongo, Cristiano; Bernardini, Sergio
2016-01-01
The evidence-based paradigm has changed and evolved medical practice. Phlebotomy, which dates back to the age of ancient Greece, has gained experience through the evolution of medicine becoming a fundamental diagnostic tool. Nowadays it connects the patient with the clinical laboratory dimension building up a bridge. However, more often there is a gap between laboratory and phlebotomist that causes misunderstandings and burdens on patient safety. Therefore, the scope of this review is delivering a view of modern phlebotomy to “bridge” patient and laboratory. In this regard the paper describes devices, tools and procedures in the light of the most recent scientific findings, also discussing their impact on both quality of blood testing and patient safety. It also addresses the issues concerning medical aspect of venipuncture, like the practical approach to the superficial veins anatomy, as well as the management of the patient’s compliance with the blood draw. Thereby, the clinical, technical and practical issues are treated with the same relevance throughout the entire paper. PMID:26981016
Diffusion theory and knowledge dissemination, utilization, and integration in public health.
Green, Lawrence W; Ottoson, Judith M; García, César; Hiatt, Robert A
2009-01-01
Legislators and their scientific beneficiaries express growing concerns that the fruits of their investment in health research are not reaching the public, policy makers, and practitioners with evidence-based practices. Practitioners and the public lament the lack of relevance and fit of evidence that reaches them and barriers to their implementation of it. Much has been written about this gap in medicine, much less in public health. We review the concepts that have guided or misguided public health in their attempts to bridge science and practice through dissemination and implementation. Beginning with diffusion theory, which inspired much of public health's work on dissemination, we compare diffusion, dissemination, and implementation with related notions that have served other fields in bridging science and practice. Finally, we suggest ways to blend diffusion with other theory and evidence in guiding a more decentralized approach to dissemination and implementation in public health, including changes in the ways we produce the science itself.
Ciraj-Bjelac, Olivera; Carinou, Eleftheria; Ferrari, Paolo; Gingaume, Merce; Merce, Marta Sans; O'Connor, Una
2016-11-01
Occupational exposure from interventional x-ray procedures is one of the areas in which increased eye lens exposure may occur. Accurate dosimetry is an important element to investigate the correlation of observed radiation effects with radiation dose, to verify the compliance with regulatory dose limits, and to optimize radiation protection practice. The objective of this work is to review eye lens dose levels in clinical practice that may occur from the use of ionizing radiation. The use of a dedicated eye lens dosimeter is the recommended methodology; however, in practice it cannot always be easily implemented. Alternatively, the eye lens dose could be assessed from measurements of other dosimetric quantities or other indirect parameters, such as patient dose. The practical implementation of monitoring eye lens doses and the use of adequate protective equipment still remains a challenge. The use of lead glasses with a good fit to the face, appropriate lateral coverage, and/or ceiling-suspended screens is recommended in workplaces with potential high eye lens doses. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.
The research-practice relationship in ergonomics and human factors--surveying and bridging the gap.
Chung, Amy Z Q; Shorrock, Steven T
2011-05-01
Significant discord has been aired regarding the widening research-practice gap in several disciplines (e.g. psychology, healthcare), especially with reference to research published in academic journals. The research-practice gap has profound and wide-ranging implications for the adequacy of ergonomics and human factors (E/HF) research and the implementation of research findings into practice. However, no substantive research on this issue has been identified in E/HF. Using an online questionnaire, practitioners were asked about their application of scientific research findings published in peer-reviewed journals and to suggest ways to improve research application in practice. A total of 587 usable responses were collected, spanning 46 countries. This article describes some of the key differences and correlations concerning reading, usefulness and barriers to application among respondents, who varied in terms of organisational type, percentage of work time devoted to application vs. research, society membership and experience. Various solutions proposed by the survey respondents on ways to bridge the research-practice gap are discussed. STATEMENT OF RELEVANCE: The relationship between research and practice in E/HF has long been a subject of discussion, with commentators pointing to tension and possible implications for the adequacy of the discipline. Findings from a cross-sectional survey provide ergonomics practitioners' views on research, leading to discussion of strategies for achieving better integration.
Practical applications of internal dose calculations
DOE Office of Scientific and Technical Information (OSTI.GOV)
Carbaugh, E.H.
1994-06-01
Accurate estimates of intake magnitude and internal dose are the goal for any assessment of an actual intake of radioactivity. When only one datum is available on which to base estimates, the choices for internal dose assessment become straight-forward: apply the appropriate retention or excretion function, calculate the intake, and calculate the dose. The difficulty comes when multiple data and different types of data become available. Then practical decisions must be made on how to interpret conflicting data, or how to adjust the assumptions and techniques underlying internal dose assessments to give results consistent with the data. This article describesmore » nine types of adjustments which can be incorporated into calculations of intake and internal dose, and then offers several practical insights to dealing with some real-world internal dose puzzles.« less
ERIC Educational Resources Information Center
Zikic, Jelena; Franklin, Mark
2010-01-01
CareerCycles (CC) career counseling framework and method of practice integrates and builds on aspects of positive psychology. Through its holistic and narrative approach, the CC method seeks to collaboratively identify and understand clients' career and life stories. It focuses on their strengths, desires, preferences, assets, future…
Peter F. Ffolliott; Gerald J. Gottfried; Duane A Bennett; Victor Manuel Hernandez C.; Alfredo Ortega-Rubio; R. H. Hamre
1992-01-01
This symposium focused on technologies that bridge the gap between research and its application in the management of woodlands. Topic areas include: ecology and silvicutural practices; growth, yield, and utilization potentials; livestock and grazing practices; wildlife habitat and values; and hydrology and watershed management. The proceedings include titles and...
ERIC Educational Resources Information Center
Katz, Ellen; Serbinski, Sarah; Mishna, Faye
2017-01-01
Social work educators often teach students clinical knowledge within a university classroom, whereas students tend to learn clinical practice through their practicum experiences. This article describes data from a cross-sectional, mixed-method study on one way to effectively bridge the gap between teaching clinical knowledge and practice to…
Development of a Contextualized ESL Bridge Curriculum. Promising Practice
ERIC Educational Resources Information Center
Office of Community College Research and Leadership, 2010
2010-01-01
Black Hawk College (BHC) is a comprehensive community college serving all or part of nine counties and a population of approximately 224,510 residents in a mostly rural area of north-west Illinois. This practice was fully developed and implemented for the Shifting Gears (SG) initiative during the 2007-08 academic years. Heeding BHC's strategic…
Social Engagements with Contemporary Art: Connecting Theory with Practice
ERIC Educational Resources Information Center
Leake, Maria D.
2014-01-01
In this article, Leake is arguing for the relevance of contemporary art as a way to bridge the gap between theory and practice in the spaces of art education. Graeme Sullivan develops a similar argument in his "Studies" article, "The Art of Research." Where Leake looks to possibilities for contemporary art as it is presented in…
Research and Practice in Education: Building Alliances, Bridging the Divide
ERIC Educational Resources Information Center
Coburn, Cynthia E., Ed.; Stein, Mary Kay, Ed.
2010-01-01
That there is a divide between research and practice is a common lament across policy-oriented disciplines, and education is no exception. Rhetoric abounds about the role research plays (or does not play) in the improvement of schools and classrooms, and policy makers push solutions that are rooted in assumptions about the way that research…
ERIC Educational Resources Information Center
Kovalcíková, Iveta
2015-01-01
Having spent over two decades training teachers, Iveta Kovalcíková writes in this editorial that she has lately been attracted by ideas bridging the growing gap between neurological and psychological research findings and their practical application in practice. Here she argues that outcomes of research on learning processes are insufficiently…
ERIC Educational Resources Information Center
Yahya, Raudhah
2016-01-01
This article explores immigrant mothers' experiences and perspectives on early learning to identify the underlying principles of parents' learning theories and their concerns about pedagogic practices at school. It employs data from interviews with nineteen immigrant mothers that reveal a discord between learning beliefs and practices at home and…
ERIC Educational Resources Information Center
Cooper, Amanda; Shewchuk, Samantha
2015-01-01
Interest in how to better connect research to policy and practice is gaining momentum globally. Also gaining widespread agreement is the view that intermediary organizations have an important role to play in facilitating multi-stakeholder partnerships between researchers, practitioners and policymakers in order to increase the mobilization of…
ERIC Educational Resources Information Center
Ogden, Terje; Christensen, Bernadette; Sheidow, Ashli J.; Holth, Per
2008-01-01
The successful nationwide transport and evaluation of Multisystemic Therapy (MST) programs in Norway is described. This description is provided within the context of the nation's movement towards the adoption of evidence-based practices (EBPs) during the past decade, the conduct of a multisite randomized clinical trial to examine the effectiveness…
Working with the Divides: Two Critical Axes in Development for Transformative Professional Practices
ERIC Educational Resources Information Center
Avery, Helen; Nordén, Birgitta
2017-01-01
Purpose: The paper aims to provide a conceptual map of how to mediate between sustainability theory and practice in higher education and how disciplinary divides can be bridged. It further looks at issues linked to knowledge views and drivers for institutional change that affect opportunities for whole institution development promoting action…
Using Electronic Communication to Bridge the Research to Practice Gap among Mentoring Professionals
ERIC Educational Resources Information Center
Smith, Cindy Ann; Willox, Lara; Olds, Courtney
2017-01-01
The field of mentoring includes a broad base of stakeholders, such as researchers and practitioners who implement mentoring programs. The research-to-practice gap is an ongoing area of concern in many fields of social science including mentoring. One reason for this is that researchers and practitioners often operate in isolation. Technology is…
The Divide between Diversity Training and Diversity Education: Integrating Best Practices
ERIC Educational Resources Information Center
King, Eden B.; Gulick, Lisa M. V.; Avery, Derek R.
2010-01-01
The fields of diversity training and diversity education have developed in a disconnected manner. This divide ensures that each field advances slowly and with narrow focus. The authors argue here that the divide should be bridged with attention to the best practices that diversity training and diversity education offer. By integrating the best…
ERIC Educational Resources Information Center
Holden, Martha J.; Izzo, Charles; Nunno, Michael; Smith, Elliott G.; Endres, Thomas; Holden, Jack C.; Kuhn, Frank
2010-01-01
This paper describes an effort to bridge research and practice in residential care through implementing a program model titled Children and Residential Experiences (CARE). The strategy involves consulting at all levels of the organization to guide personnel to incorporate CARE evidence-based principles into daily practice, and fostering an…
ERIC Educational Resources Information Center
Normore, Anthony H., Ed.
2008-01-01
Within this book Leadership for Social Justice: Promoting Equity and Excellence Through Inquiry and Reflective Practice the contributors provide a variety of rich perspectives to the social justice phenomenon from the lens of empirical, historical, narrative, and conceptual designs. These designs reiterate the importance of bridging theory and…
ERIC Educational Resources Information Center
Sundstrom, Malin; Hagberg, Johan
2010-01-01
This paper describes the planning, implementation and outcome of a graduate-level consumer behaviour course taught in autumn 2008 at the University of Boras in Sweden. The course was jointly developed by marketing academics and business representatives in order to combine research-oriented studies with practical experience in a retail context. The…
The Linkage between Research and Practice in Adult Education.
ERIC Educational Resources Information Center
Dohmen, Gunther
Empirical research in education seems to have an international tendency to concentrate on problems that can be grasped adequately. But that approach tends to direct more research to smaller and smaller areas, where results are more precise but more irrelevant for the complex practice of education. To try to bridge this gap between research and…
Accounting Practitioners Reflect on Faculty Impact: Bridging the Gap between Theory and Practice
ERIC Educational Resources Information Center
Johnson, Ryan
2014-01-01
A gap exists between the perception of accounting education in the classroom and accounting as it is practiced. This study explores qualitatively the perceptions and experiences of mid-career accounting professionals with respect to the impact of academic faculty on their careers in accounting. The study identifies a perception gap in the…
The Anatomy of Program Design for an On-Line Business Management Course
ERIC Educational Resources Information Center
Barger, Bonita
2008-01-01
How does one design an on-line course to bridge theory and practice? How can the feedback of on-going stakeholder (student and administration) be incorporated into the design process to enhance quality? This paper presents the theoretical underpinning of designing an on-line management course recognized as best practice for a "well organized…
Veth, Klaske N; Van der Heijden, Beatrice I J M; Korzilius, Hubert P L M; De Lange, Annet H; Emans, Ben J M
2018-01-01
This two-wave complete panel study aims to examine human resource management (HRM) bundles of practices in relation to social support [i.e., leader-member exchange (LMX), coworker exchange (CWX)] and employee outcomes (i.e., work engagement, employability, and health), within a context of workers aged 65+. Based upon the social exchange theory and the Job Demands-Resources (JD-R) framework, it was hypothesized that HRM bundles at Time 1 would increase bridge workers' outcomes at Time 2, and that this relationship would be mediated by perceptions of LMX and CWX at Time 2. Using a longitudinal design, hypotheses were tested in a unique sample of Dutch bridge employees ( N = 228). Results of several structural equation modeling analyses revealed no significant associations between HRM bundles, and social support, moreover, no significant associations were found in relation to employee outcomes. However, the results of the best-fitting final model revealed the importance of the impact of social support on employee (65+) outcomes over time.
Kalkan, Erol; Chopra, Anil K.
2010-01-01
Earthquake engineering practice is increasingly using nonlinear response history analysis (RHA) to demonstrate performance of structures. This rigorous method of analysis requires selection and scaling of ground motions appropriate to design hazard levels. Presented herein is a modal-pushover-based scaling (MPS) method to scale ground motions for use in nonlinear RHA of buildings and bridges. In the MPS method, the ground motions are scaled to match (to a specified tolerance) a target value of the inelastic deformation of the first-'mode' inelastic single-degree-of-freedom (SDF) system whose properties are determined by first-'mode' pushover analysis. Appropriate for first-?mode? dominated structures, this approach is extended for structures with significant contributions of higher modes by considering elastic deformation of second-'mode' SDF system in selecting a subset of the scaled ground motions. Based on results presented for two bridges, covering single- and multi-span 'ordinary standard' bridge types, and six buildings, covering low-, mid-, and tall building types in California, the accuracy and efficiency of the MPS procedure are established and its superiority over the ASCE/SEI 7-05 scaling procedure is demonstrated.
Calladine, C R
2015-04-13
Davies Gilbert's work on the catenary is notable on two counts. First, it influenced Thomas Telford in formulating his final design for the Menai Strait suspension bridge (1826); and second, it established for the first time the form of the 'catenary of equal strength'. The classical catenary is a uniform flexible chain or cable hanging freely under gravity between supports. The 'catenary of equal strength' is the form of a cable whose cross-sectional area is made proportional to the tension at each point, so that the tensile stress is uniform throughout. In this paper I provide a sketch of the lives and achievements of Gilbert and Telford, and of their interaction over the Menai Bridge. There follows a commentary on Gilbert's 1826 paper, and on his two related publications; and a brief sketch of the earlier history of the catenary. I then describe the development of the suspension bridge up to the present time. Finally, I discuss relations between mathematical analysts and practical engineers. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.
Bosco-Lauth, Angela M; Bowen, Richard A; Root, J Jeffrey
2016-08-01
Emergent H7N9 influenza A virus has caused multiple public health and financial hardships. While some epidemiological studies have recognized infected chickens as an important bridge for human infections, the generality of this observation, the minimum infectious dose, and the shedding potential of chickens have received conflicting results. We experimentally tested the ability of domestic chickens (Gallus gallus domesticus) to transmit H7N9 to co-housed chickens and to several other animal species in an experimental live animal market. Results indicated that an infected chicken failed to initiate viral shedding of H7N9 to naïve co-housed chickens. The infected chicken did, however, successfully transmit the virus to quail (Coturnix sp.) located directly below the infected chicken cage. Oral shedding by indirectly infected quail was, on average, greater than ten-fold that of directly inoculated chickens. Best management practices in live animal market systems should consider the position of quail in stacked-cage settings. Copyright © 2016 Elsevier Inc. All rights reserved.
A sustainable dietetics bridging program: development and implementation in Atlantic Canada.
Lordly, Daphne; Guy, Jennifer; Barry, Paula; Garus, Jennifer
2014-01-01
A provincial focus on immigration and improved foreign credential recognition has led to an investigation of best practices and subsequent recommendations for the development and implementation of a sustainable university-based bridging program for internationally educated dietitians in Atlantic Canada. Data were collected from various sources and used to inform program decisions and direction. An advisory framework was established through a core group representing dietetics education and regulation and internationalization. Subsequently, a key stakeholder group was formed. As a result of this collaboration and research, a dietetics bridging framework was developed and a program pilot tested. Lessons learned may inform similar endeavours and highlight the importance of collaborative leadership and collaboration among multiple stakeholders, and of creatively addressing program sustainability issues while keeping learners (internationally educated dietitians) at the centre.
Resin-retained bridges re-visited. Part 1. History and indications.
St George, Geoffrey; Hemmings, Ken; Patel, Kalpesh
2002-07-01
Resin-retained bridges have been used clinically since the 1970s, and offer a more conservative approach to the restoration of edentulous spaces than conventional bridgework. They are easy to place, cheap to fabricate and have been shown to be cost effective. Despite this, they are not frequently used in general dental practice and they have an undeserved reputation for failure. Since their initial introduction, they have undergone a number of changes to their method of retention, and the materials used in their construction. This has resulted in a predictable, aesthetic restoration which, barring the use of implants, is often the treatment of choice where teeth adjacent to an edentulous space are minimally or not restored. This first article details the history, advantages, indications, and designs of resin-retained bridges.
Kalya, Anantharam; Jaroszewski, Dawn; Pajaro, Octavio; Scott, Robert; Gopalan, Radha; Kasper, Diane; Arabia, Francisco
2013-01-01
Cardiac allograft rejection and failure may require mechanical circulatory support as bridge-to-retransplantation. Prognosis in this patient group is poor and implantable ventricular assist devices have had limited success due to organ failure associated with the high dose immunosuppression required to treat ongoing rejection. We present a case from our institution and the world-wide experience utilizing the SynCardia CardioWest Total Artificial Heart (TAH-t; SynCardia Systems, Inc., Tucson, AZ, USA) for replacement of the failing graft, recovery of patient and end-organ failure with ultimate bridge to retransplantation. We present our experience and review of world-wide experience for use of TAH-t in this type patient. © 2013 John Wiley & Sons A/S.
Proposed testing of concrete sealers.
DOT National Transportation Integrated Search
2017-07-04
Chlorides, in sufficient concentrations, will cause corrosion of steel reinforcement in bridge decks. Previous studies have shown that de-icing chemicals and practices used by the Kentucky Transportation Cabinet (KYTC) can result in problematic level...
ERIC Educational Resources Information Center
Howie, Jim; Jordan, Jeff; Millson, David
1999-01-01
Describes a dart-making project that is used as a comprehensive introduction to machining in beginning metals and technology classes. It helps the students bridge the gap between theory and practice by integrating science and technology. (JOW)
NASA Astrophysics Data System (ADS)
Remillard, C. M.; Madden, M.; Favors, J.; Childs-Gleason, L.; Ross, K. W.; Rogers, L.; Ruiz, M. L.
2016-06-01
The NASA DEVELOP National Program bridges the gap between NASA Earth Science and society by building capacity in both participants and partner organizations that collaborate to conduct projects. These rapid feasibility projects highlight the capabilities of satellite and aerial Earth observations. Immersion of decision and policy makers in these feasibility projects increases awareness of the capabilities of Earth observations and contributes to the tools and resources available to support enhanced decision making. This paper will present the DEVELOP model, best practices, and two case studies, the Colombia Ecological Forecasting project and the Miami-Dade County Ecological Forecasting project, that showcase the successful adoption of tools and methods for decision making. Through over 90 projects each year, DEVELOP is always striving for the innovative, practical, and beneficial use of NASA Earth science data.
Weeks, Keith W; Meriel Hutton, B; Coben, Diana; Clochesy, John M; Pontin, David
2013-03-01
When designing learning and assessment environments it is essential to articulate the underpinning education philosophy, theory, model and learning style support mechanisms that inform their structure and content. We elaborate on original PhD research that articulates the design rationale of authentic medication dosage calculation problem-solving (MDC-PS) learning and diagnostic assessment environments. These environments embody the principles of authenticity, building knowledge and skills and competency assessment and are designed to support development of competence and bridging of the theory-practice gap. Authentic learning and diagnostic assessment environments capture the features and expert practices that are located in real world practice cultures and recreate them in authentic virtual clinical environments. We explore how this provides students with a safe virtual authentic environment to actively experience, practice and undertake MDC-PS learning and assessment activities. We argue that this is integral to the construction and diagnostic assessment of schemata validity (mental constructions and frameworks that are an individual's internal representation of their world), bridging of the theory-practice gap and cognitive and functional competence development. We illustrate these principles through the underpinning pedagogical design of two online virtual authentic learning and diagnostic assessment environments (safeMedicate and eDose™). Copyright © 2012. Published by Elsevier Ltd.
Moya, Eva M.; Chavez-Baray, Silvia Maria; Martinez, Omar; Mattera, Brian; Adcox, Courtney
2018-01-01
Research and scholarship efforts continue to promote the integration of micro and macro practice in social work practice and education. Despite this, scholarship has documented persistent challenges in the fluid integration between the domains of micro-level service provision and macro-level social change efforts in practice and academic programs. This paper outlines a successful bridge between the micro-macro divide in the form of community-engaged practice to address homelessness and social work education in the U.S.-Mexico border region. MSW students enrolled in a macro-level course at the University of Texas at El Paso’s College of Health Sciences successfully partnered with the Opportunity Center for the Homeless, a grassroots community-based organization serving individuals experiencing homelessness. The narrative describes how students were effectively able to apply both micro- and macro-level skills learned in the classroom to an experiential learning environment while providing much-needed assistance to an underfunded community-based organization. A set of challenges and recommendations are also discussed. Research initiatives are needed to evaluate and test clinical and community work initiatives, including the use of photovoice methodology to address homelessness, while being responsive to community needs and challenges. PMID:29809204
Moya, Eva M; Chavez-Baray, Silvia Maria; Martinez, Omar; Mattera, Brian; Adcox, Courtney
2018-01-01
Research and scholarship efforts continue to promote the integration of micro and macro practice in social work practice and education. Despite this, scholarship has documented persistent challenges in the fluid integration between the domains of micro-level service provision and macro-level social change efforts in practice and academic programs. This paper outlines a successful bridge between the micro-macro divide in the form of community-engaged practice to address homelessness and social work education in the U.S.-Mexico border region. MSW students enrolled in a macro-level course at the University of Texas at El Paso's College of Health Sciences successfully partnered with the Opportunity Center for the Homeless, a grassroots community-based organization serving individuals experiencing homelessness. The narrative describes how students were effectively able to apply both micro- and macro-level skills learned in the classroom to an experiential learning environment while providing much-needed assistance to an underfunded community-based organization. A set of challenges and recommendations are also discussed. Research initiatives are needed to evaluate and test clinical and community work initiatives, including the use of photovoice methodology to address homelessness, while being responsive to community needs and challenges.
Vibration-based monitoring for performance evaluation of flexible civil structures in Japan
FUJINO, Yozo
2018-01-01
The vibration-based monitoring of flexible civil structures and performance evaluation from this monitoring are reviewed, with an emphasis on research and practice in Japan and the author’s experiences. Some new findings and unexpected vibrations from the monitoring of real bridges and buildings are reported to emphasize the importance of monitoring. Future developments and applications of vibration-based monitoring to civil infrastructure management are also described. Many examples are taken from the author’s past 30 years’ experience of research on bridge dynamics. PMID:29434082
Wongcharoen, Wanwarang; Pinyosamosorn, Kittipong; Gunaparn, Siriluck; Boonnayhun, Suchada; Thonghong, Tasalak; Suwannasom, Pannipa; Phrommintikul, Arintaya
2017-08-01
Warfarin discontinuation with heparin bridging is a common practice in patients receiving warfarin prior to elective coronary angiography (CAG). The uninterrupted warfarin strategy has been suggested to be alternative option for patients with high thromboembolic risk. Therefore, we aimed to assess the safety of elective transfemoral CAG during uninterrupted warfarin therapy compared to heparin bridging. This study was a randomized open-label design with blinded event evaluation. The 110 consecutive patients (age ≥ 18 years) receiving warfarin before the planned transfemoral CAG were randomly assigned to either heparin bridging or uninterrupted warfarin with targeted INR (2.0-3.0). The primary outcome was the incidence of major vascular access site complications. The baseline characteristics were comparable between two groups (mean age was 60.1 ± 7.8 years, 49 males). The mean INR on the day of CAG of heparin bridging and uninterrupted warfarin groups was 1.2 ± 0.3 and 2.2 ± 0.5 (P < 0.001). The major vascular access site complications occurred in 3 of 55 (5.5%) heparin-bridging patients and in none of 55 uninterrupted warfarin patients (P = 0.243). The total vascular access site complications occurred in 6 (10.9%) heparin-bridging and one (1.8%) uninterrupted warfarin patients (P = 0.113). No patient developed either other bleeding or thromboembolic events during 7 days after CAG. We demonstrated that an uninterrupted warfarin strategy did not increase vascular access site complications in patients undergoing transfemoral CAG compared to heparin bridging therapy. Due to the safety and the ease of uninterrupted warfarin strategy, this approach should be encouraged in patients receiving long-term warfarin who undergo elective transfemoral CAG. © 2017, Wiley Periodicals, Inc.
Non-destructive inspection protocol for reinforced concrete barriers and bridge railings
DOE Office of Scientific and Technical Information (OSTI.GOV)
Chintakunta, Satish R.; Boone, Shane D.
Reinforced concrete highway barriers and bridge railings serve to prevent errant vehicles from departing the travel way at grade separations. Despite the important role that they play in maintaining safety and their ubiquitous nature, barrier inspection rarely moves beyond visual inspection. In August 2008, a tractor-trailer fatally departed William Preston Lane, Jr. Memorial Bridge after it dislodged a section of the bridge barrier. Investigations following the accident identified significant corrosion of the anchor bolts attaching the bridge railing to the bridge deck. As a result of the information gathered during its investigation of the accident, the National Transportation Safety Boardmore » (NTSB) made recommendations to the Federal Highway Administration concerning Non-Destructive Evaluation (NDE) of concrete bridge railings. The Center for nondestructive evaluation (NDE) at Turner Fairbank Highway Research Center in McLean, VA is currently evaluating feasibility of using four technologies - ground penetrating radar (GPR), ultrasonic pulse-echo, digital radiography and infrared thermal imaging methods to develop bridge inspection methods that augment visual inspections, offer reliable measurement techniques, and are practical, both in terms of time and cost, for field inspection work. Controlled samples containing predefined corrosion levels in reinforcing steel were embedded at barrier connection points for laboratory testing. All four NDE techniques were used in the initial phase I testing. An inspection protocol for detecting and measuring the corrosion of reinforced steel embedded in the anchorage system will be developed as part of phase II research. The identified technologies shall be further developed for field testing utilizing a structure with a barrier in good condition and a structure with a barrier in poor condition.« less
Fitzmaurice, D A; Hobbs, F D; Murray, E T; Bradley, C P; Holder, R
1996-09-01
Increasing indications for oral anticoagulation has led to pressure on general practices to undertake therapeutic monitoring. Computerized decision support (DSS) has been shown to be effective in hospitals for improving clinical management. Its usefulness in primary care has previously not been investigated. To test the effectiveness of using DSS for oral anticoagulation monitoring in primary care by measuring the proportions of patients adequately controlled, defined as within the appropriate therapeutic range of International Normalised Ratio (INR). All patients receiving warfarin from two Birmingham inner city general practices were invited to attend a practice-based anticoagulation clinic. In practice A all patients were managed using DSS. In practice B patients were randomized to receive dosing advice either through DSS or through the local hospital laboratory. Clinical outcomes, adverse events and patient acceptability were recorded. Forty-nine patients were seen in total. There were significant improvements in INR control from 23% to 86% (P > 0.001) in the practice where all patients received dosing through DSS. In the practice where patients were randomized to either DSS or hospital dosing, logistic regression showed a significant trend for improvement in intervention patients which was not apparent in the hospital-dosed patients (P < 0.001). Mean recall times were significantly extended in patients who were dosed by the practice DSS through the full 12 months (24 days to 36 days) (P = 0.033). Adverse events were comparable between hospital and practice-dosed patients, although a number of esoteric events occurred. Patient satisfaction with the practice clinics was high. Computerized DSS enables the safe and effective transfer of anticoagulation management from hospital to primary care and may result in improved patient outcome in terms of the level of control, frequency of review and general acceptability.
Evaluating the role of clinical pharmacists in pre-procedural anticoagulation management.
Kataruka, Akash; Renner, Elizabeth; Barnes, Geoffrey D
2018-02-01
While physicians are typically responsible for managing perioperative warfarin, clinic pharmacists may improve pre-procedural decision-making. We assessed the impact of pharmacist-driven care for chronic warfarin-treated patients undergoing outpatient right heart catheterization (RHC). 200 warfarin patients who underwent RHC between January 2012 and September 2015 were analyzed. Pharmacist-care (n = 79) was compared to the usual care model (n = 121). The primary outcome was a composite of (1) documentation of anticoagulation plan, (2) holding warfarin at least 5 days prior to procedure, (3) guideline-congruent low molecular weight heparin (LMWH) bridging, and (4) correct LMWH dosing if bridging deemed necessary. Chi-squared test performed to assess the role of pharmacist. A multivariable logistic regression analysis was performed to the composite endpoint, adjusted for the month of procedure. Compared to the usual care model, pharmacist-driven care (OR 4.69, 95% CI 1.73-12.71, p = 0.002) and date of the procedure (OR 1.06/month, 95% CI 1.01-1.10, p = 0.011) were independently associated with the primary composite outcome. Of the individual outcome components, pharmacist-driven care was only associated with documentation (96.2% vs. 67.8%, OR 9.19, 95% CI 2.19-38.62, p = 0.002). Remaining components including hold warfarin for at least 5 days, appropriate bridging and correct LMWH dosing were not significantly associated with pharmacist-care. Pharmacist-care is associated with better guideline-based anticoagulation management, but this was primarily driven by improved documentation. The impact of pharmacist managed peri-procedural anticoagulation on clinical outcomes remains unknown.
Cardiovascular effects of two disulfide analogues of sarafotoxin S6b.
Lin, W W; Chen, Y M; Lee, S Y; Nishio, H; Kimura, T; Sakakibara, S; Lee, C Y
1990-01-01
Sarafotoxin S6b (STX-b), a peptide toxin isolated from the venom of the Israeli burrowing asp, Atractaspis engaddensis, consists of 21 amino acid residues with four cysteines at positions 1,3,11 and 15. In the present study, we compared the cardiovascular effects of two synthetic STX-b analogues with different disulfide bridge locations, i.e. STX-b type A (1-15, 3-11) and STX-b type B (1-11, 3-15). At doses of 0.3-3 nmoles/kg (i.v.), type A produced a sustained pressor effect with transient increase in pulse pressure. However, at 5 nmoles/kg, it produced a transient increase followed by decrease in blood pressure, heart rate and respiratory rate within 30 sec and 12 out of 13 mice died within 10 min. Various kinds of ECG changes, suggestive of myocardial ischemia and hyperkalemia, were observed. Type A also caused a significant increase in the plasma levels of K+, lactate dehydrogenase, creatine phosphokinase, inorganic phosphate and glucose. By contrast, type B did not kill any mouse at doses up to 50 nmoles/kg. In the rat aorta, type A caused a potent vasoconstriction which was dependent on extracellular Ca2+ and was partially inhibited by verapamil and H-7, a protein kinase C inhibitor. In the rat Langendorff heart preparation, type A produced coronary vasospasm with potency about 100 times higher than that of type B. A similar potency ratio was observed for the positive inotropic effect in rat atria. These results indicate that the location of disulfide bridges in sarafotoxin S6b markedly influences the pharmacological potency and the natural sarafotoxin S6b should be type A with the disulfide bridge locations at positions 1-15 and 3-11.
Treating pulmonary embolism in Pacific Asia with direct oral anticoagulants.
Cohen, Alexander; Jeyaindran, Sinnadurai; Kim, Jae Yeol; Park, Kihyuk; Sompradeekul, Suree; Tambunan, Karmel L; Tran, Huyen; Tsai, I-Chen; Ward, Christopher; Wong, Raymond
2015-08-01
Pulmonary embolism (PE) is the principal preventable cause of in-hospital deaths. Prevalence of PE in Asians is uncertain but undoubtedly underestimated. Asians and Caucasians have similar non-genetic risk factors for PE, and there is mounting evidence that PE affects Asians much more commonly than previously supposed; incidence, especially among high-risk patients, may approach that in Caucasians. Furthermore, PE incidence in Asia is increasing, due to both increased ascertainment, and also population ageing and growing numbers of patients with predisposing risk factors. Despite being warranted, thromboprophylaxis for high-risk patients is not routine in Pacific Asian countries/regions. There also appears to be scope to implement venous thromboembolism (VTE) management guidelines more assiduously. Anticoagulants, primarily heparins and warfarin, have been the mainstays of VTE management for years; however, these agents have limitations that complicate routine use. The complexity of current guidelines has been another barrier to applying evidence-based recommendations in everyday practice. Updated management approaches have considerable potential to improve outcomes. New oral anticoagulants that are easier to administer, require no, or much less, monitoring or dose-adjustment and have a favourable risk/benefit profile compared with conventional modalities, may offer an alternative with the potential to simplify VTE management. However, more information is required on practical management and the occurrence and treatment of bleeding complications. Increasing recognition of the burden of PE and new therapeutic modalities are altering the VTE management landscape in Pacific Asia. Consequently, there is a need to further raise awareness and bridge gaps between the latest evidence and clinical practice. Copyright © 2015. Published by Elsevier Ltd.
Bridging Social Justice and Children's Rights to Enhance School Psychology Scholarship and Practice
ERIC Educational Resources Information Center
Shriberg, David; Desai, Poonam
2014-01-01
This article describes the overlap between the common goals of social justice and children's rights advocates as applied to scholarship and practice in school psychology. We argue that these frameworks overlap a great deal, with a primary distinction being the roots of each approach. Specifically, the origins of social justice movements in…
ERIC Educational Resources Information Center
Wasonga, C. O.; Wanzare, Z. O.; Dawo, J. I.
2015-01-01
Research on quality and relevance of pre-service teacher training programmes has found out that their products are ill-prepared for service delivery in schools. This is because there seems to be a disconnect between the college curriculum and the job in-practice. Given the critical nature of teacher input in the teaching-learning chain of…
ERIC Educational Resources Information Center
Rönnerman, Karin; Salo, Petri; Furu, Eli Moksnes; Lund, Torbjørn; Olin, Anette; Jakhelln, Rachel
2016-01-01
In this article we present the Nordic Network for Action Research, established in 2004. We describe how the network has explored, bridged and nurtured the inherent action research dynamics of ideology and methodology. This has been done through an understanding anchored in educational traditions, and by focus on three important ideal-shaping…
ERIC Educational Resources Information Center
Campbell, Sara Sunshine
2012-01-01
Teacher education programs have been criticized as too theoretical with university courses disconnected from the practical realities of classrooms. This single case study investigates a model of teacher education that worked to bridge the coursework-fieldwork gap in teacher education. The Mediated Field Experience (MFE) is a field experience…
ERIC Educational Resources Information Center
Stead, Martine; Stradling, Robert; MacNeil, Morag; MacKintosh, Anne Marie; Minty, Sarah; McDermott, Laura; Eadie, Douglas
2010-01-01
Aims: The study examined normative school drug-education practice in Scotland and the extent to which it reflected the evidence base for effective drug education. Methods: Current guidance in Scotland was compared with systematic review evidence on drug-education effectiveness; a survey was mailed to primary, secondary and special schools (928…
An Assessment of the Army Officer Education System From an Adult Learning Perspective
2005-05-26
learning 2 Brockett, Ralph, and Roger Hiemstra. "Bridging the Theory -Practice Gap in Self-Directed... Learning ." In Self-Directed Learning : From Theory to Practice, edited by S. Brookfield. New Directions for Continuing Education No. 25. (San...offers conclusions and recommendations about the Army Officer Education System based on analysis from adult learning theory . Statement of the
The CABES (Clare Adult Basic Education Service) Framework as a Tool for Teaching and Learning
ERIC Educational Resources Information Center
Greene, Moira
2015-01-01
This article describes a Framework that can be used to help bridge the gap between theory and practice in adult learning. The Framework promotes practice informed by three strands important to adult literacy work: social theories of literacy, social-constructivist learning theory and principles of adult learning. The Framework shows how five key…
A Conceptual Framework for Educational Design at Modular Level to Promote Transfer of Learning
ERIC Educational Resources Information Center
Botma, Yvonne; Van Rensburg, G. H.; Coetzee, I. M.; Heyns, T.
2015-01-01
Students bridge the theory-practice gap when they apply in practice what they have learned in class. A conceptual framework was developed that can serve as foundation to design for learning transfer at modular level. The framework is based on an adopted and adapted systemic model of transfer of learning, existing learning theories, constructive…
ERIC Educational Resources Information Center
Parsons, Sarah; Charman, Tony; Faulkner, Rachel; Ragan, Jude; Wallace, Simon; Wittemeyer, Kerstin
2013-01-01
While the last 10 years have seen a significant increase in research published on early intervention and autism, there is a persistent disconnect between educational research and practice. Governments have invested significant funds in autism education, and a range of approaches have been implemented in schools, but there is limited research…
ERIC Educational Resources Information Center
Brown, Corina E.; Henry, Melissa L. M.; Barbera, Jack; Hyslop, Richard M.
2012-01-01
This study focused on the undergraduate course that covers basic topics in general, organic, and biological (GOB) chemistry at a mid-sized state university in the western United States. The central objective of the research was to identify the main topics of GOB chemistry relevant to the clinical practice of nursing. The collection of data was…
ERIC Educational Resources Information Center
Sawaki, Yasuyo; Koizumi, Rie
2017-01-01
This small-scale qualitative study considers feedback and results reported for two major large-scale English language tests administered in Japan: the Global Test of English Communication for Students (GTECfS) and the Eiken Test in Practical English Proficiency (Eiken). Specifically, it examines current score-reporting practices in student and…
ERIC Educational Resources Information Center
Williams, Conor P.
2015-01-01
On December 11, 2014, "New America" convened a group of leading experts on dual language learners (DLLs) to launch its new Dual Language Learners National Work Group. The group aimed to address three questions: (1) What are the key best practices for dual language learner instruction, policy, and research?; (2) What are the areas of…
ERIC Educational Resources Information Center
Cragg, Stephanie J.; Carter, Irene; Nikolova, Kristina
2013-01-01
The School of Social Work and Disability Studies Accessibility Planning Committee (APC) is a student-driven initiative that has been in existence for over 10 years. This practice brief looked at the committee through interviews with faculty and student members. The investigation aimed to determine whether the benefits of having a student-driven…
ERIC Educational Resources Information Center
Chueh, Ho-chia; Chen, Ya-Tung
2014-01-01
Participation in service-learning courses has always been considered a part of the informal education in tertiary education worldwide. Originating from the assumption that service-learning courses increase students' civic engagement and bridge the gap between knowledge and practice, service-learning courses have gradually acquired the status of…
Research, Policy, and Practice in Action: The Office of Community College Research and Leadership
ERIC Educational Resources Information Center
Zamani-Gallaher, Eboni M.; Bragg, Debra D.
2015-01-01
The Office for Community College Research and Leadership (OCCRL) founded in 1989 focuses on P-20 education and the role of community colleges in facilitating educational access and equity. This article highlights the work of OCCRL as a research center that bridges inquiry, policy, and practice in contributing to the national dialogue on relevant…
Revisiting the Blended Learning Literature: Using a Complex Adaptive Systems Framework
ERIC Educational Resources Information Center
Wang, Yuping; Han, Xibin; Yang, Juan
2015-01-01
This research has two aims: (1) to bridge a gap in blended learning research--the lack of a systems approach to the understanding of blended learning research and practice, and (2) to promote a more comprehensive understanding of what has been achieved and what needs to be achieved in blended learning research and practice. To achieve these aims,…
ERIC Educational Resources Information Center
Kocsis-McNerney, Violet
2013-01-01
This research obtained information using focus groups as qualitative method to determine the factors that influenced alternative education decisions. The purpose of this study was to help bridge theory, research, and educational practices and examine policy reform efforts. Through the lenses of returning adult education students, this research…
Reflections on Global Developments in Media Literacy Education: Bridging Theory and Practice
ERIC Educational Resources Information Center
Hobbs, Renee; Felini, Damiano; Cappello, Gianna
2011-01-01
The field of media literacy education is maturing, as evidenced by the quality of presentations of research and practice shared at the 2010 World Summit on Children and Media in Karlstad. In this article, we offer our reflections on the opportunities and challenges faced by media literacy educators as we build our global community network, develop…
Bridging the Theory/Practice Divide in Education: Seeing Reading as Research and Research as Reading
ERIC Educational Resources Information Center
Boody, Robert M.
2010-01-01
For decades there has been a divide between educational research and practice. Sometimes the blame is placed on teachers for not following research-based strategies or not being trained well enough to read the literature. Just as frequently the blame is placed on researchers for not (a) studying topics important to teachers, (b) writing them so…
Evaluation of Health Plan Interventions to Influence Chronic Opioid Therapy Prescribing
Saunders, Kathleen; Shortreed, Susan; Thielke, Stephen; Turner, Judith A.; LeResche, Linda; Beck, Randi; Von Korff, Michael
2015-01-01
Objectives Evaluate health plan interventions targeting physician chronic opioid therapy (COT) prescribing. Methods In 2006, Group Health’s (GH) integrated group practice (IGP) initiated diverse interventions targeting COT prescriber norms and practices. In 2010, the IGP implemented a COT guideline, including a mandated online course for physicians managing COT. These interventions were not implemented in GH’s network practices. We compared trends in GH-IGP and network practices for 2006–12 in the percent of patients receiving COT and their opioid dose. We compared physician beliefs before versus after the mandated course and pre- to post-course changes in COT dosing for IGP physicians who took the course. Results From 2006 to 2012, mean (SE) daily opioid dose among IGP COT patients (intervention setting) declined from 74.1 (1.9) mg. morphine equivalent dose (MED) to 48.3 (1.0) mg. MED. Dose changes among GH network COT patients (control setting) were modest—88.2 (5.0) mg. MED in 2006 to 75.7 (2.3) mg. MED in 2012. Among physicians taking the mandated course in 2011, we observed pre- to post-course changes toward more conservative opioid prescribing beliefs. However, COT dosing trends did not change pre- to post-course. Discussion Following initiatives implemented to alter physician prescribing practices and norms, mean opioid dose prescribed to COT patients declined more in intervention than control practices. Physicians reported more conservative beliefs regarding opioid prescribing immediately after completing an online course in 2011, but the course was not associated with additional reductions in mean daily opioid dose prescribed by physicians completing the course. PMID:25621426
Exercise Dose in Clinical Practice
Wasfy, Meagan; Baggish, Aaron L.
2016-01-01
There is wide variability in the physical activity patterns of the patients in contemporary clinical cardiovascular practice. This review is designed to address the impact of exercise dose on key cardiovascular risk factors and on mortality. We begin by examining the body of literature that supports a dose-response relationship between exercise and cardiovascular disease risk factors including plasma lipids, hypertension, diabetes mellitus, and obesity. We next explore the relationship between exercise dose and mortality by reviewing the relevant epidemiological literature underlying current physical activity guideline recommendations. We then expand this discussion to critically examine recent data pertaining to the impact of exercise dose at the lowest and highest ends of the spectrum. Finally, we provide a framework for how the key concepts of exercise dose can be integrated into clinical practice. PMID:27267537
Exercise Dose in Clinical Practice.
Wasfy, Meagan M; Baggish, Aaron L
2016-06-07
There is wide variability in the physical activity patterns of the patients in contemporary clinical cardiovascular practice. This review is designed to address the impact of exercise dose on key cardiovascular risk factors and on mortality. We begin by examining the body of literature that supports a dose-response relationship between exercise and cardiovascular disease risk factors, including plasma lipids, hypertension, diabetes mellitus, and obesity. We next explore the relationship between exercise dose and mortality by reviewing the relevant epidemiological literature underlying current physical activity guideline recommendations. We then expand this discussion to critically examine recent data pertaining to the impact of exercise dose at the lowest and highest ends of the spectrum. Finally, we provide a framework for how the key concepts of exercise dose can be integrated into clinical practice. © 2016 American Heart Association, Inc.
Towards a robust assessment of bridge clogging processes in flood risk management
NASA Astrophysics Data System (ADS)
Gschnitzer, T.; Gems, B.; Mazzorana, B.; Aufleger, M.
2017-02-01
River managers are aware that wood-clogging mechanisms frequently trigger damage-causing processes like structural damages at bridges, sudden channel outbursts, and occasionally, major displacements of the water course. To successfully mitigate flood risks related to the transport of large wood (LW), river managers need a guideline for an accurate and reliable risk assessment procedure and the design of river sections and bridges that are endangered of LW clogging. In recent years, comprehensive research dealing with the triggers of wood-clogging mechanisms at bridges and the corresponding impacts on flood risk was accomplished at the University of Innsbruck. A large set of laboratory experiments in a rectangular flume was conducted. In this paper we provide an overall view of these tests and present our findings. By applying a logistic regression analysis, the available knowledge on the influence of geometrical, hydraulic, and wood-related parameters on LW clogging probabilities is processed in a generalized form. Based on the experimental modeling results a practice-oriented guideline that supports the assessment of flood risk induced by LW clogging, is presented. In this context, two specific local structural protection measures at the bridge, aiming for a significant decrease of the entrapment probabilities, are illustrated: (i) a deflecting baffle installed on the upstream face of the bridge and (ii) a channel constriction leading to a change in flow state and a corresponding increase of the flow velocities and the freeboard at the bridge cross section. The presented guideline is based on a three-step approach: estimation of LW potential, entrainment, and transport; clogging scenario at the bridge; and the impact on channel and floodplain hydraulics. For a specific bridge susceptible to potential clogging caused by LW entrapment, it allows for a qualitative evaluation of potential LW entrainment in the upstream river segments, its transport toward the hydraulic bottleneck, and for a quantification of expected entrapment probabilities. Depending on the amount and characteristics of the impacting LW, consequences of bridge clogging can be determined and LW bridge-clogging scenarios can be considered within hydrodynamic numerical modeling.
Hatlevik, Ida Katrine Riksaasen
2012-04-01
This paper is a report of a correlational study of the relations of nursing students' acquired reflective skills, practical skills and theoretical knowledge on their perception of coherence between theory and practice. Reflection is considered a key factor in bridging the gap between theory and practice. However, it is not evident whether reflective skills are primarily generic in nature or whether they develop from a theoretical knowledge base or the acquisition of practical skills. This study is a secondary analysis of existing data. The data are part of a student survey that was conducted among third-year nursing students in Norway during the spring of 2007. A total of 446 nursing students participated in this study and the response rate was 71%. Structural equation modelling analyses were performed. The results indicate that students' perception of coherence between theory and practice during initial nursing education is directly influenced by reflective skills and theoretical knowledge. The results also reveal that reflective skills have mediating effects and that practical skills have a fully mediated and theoretical knowledge a partially mediated influence on students' perception of coherence. The findings imply that helping students perceive coherence between theory and practice in nursing education, developing students' reflective skills and strengthening the theoretical components of the initial nursing education programme might be beneficial. The results suggest that reflective thinking is not merely a generic skill but rather a skill that depends on the acquisition of relevant professional knowledge and experience. © 2011 Blackwell Publishing Ltd.
Hickman, Louise D; DiGiacomo, Michelle; Phillips, Jane; Rao, Angela; Newton, Phillip J; Jackson, Debra; Ferguson, Caleb
2018-04-01
The nursing profession has a significant evidence to practice gap in an increasingly complex and dynamic health care environment. To evaluate effectiveness of teaching and learning strategies related to a capstone project within a Masters of Nursing program that encourage the development of evidence based practice capabilities. Systematic review that conforms to the PRISMA statement. Master's Nursing programs that include elements of a capstone project within a university setting. MEDLINE, CINAHL, Cochrane Database of Systematic Reviews, ERIC and PsycInfo were used to search for RCT's or quasi experimental studies conducted between 1979 and 9 June 2017, published in a peer reviewed journal in English. Of 1592 studies, no RCT's specifically addressed the development of evidence based practice capabilities within the university teaching environment. Five quasi-experimental studies integrated blended learning, guided design processes, small group work, role play and structured debate into Masters of Nursing research courses. All five studies demonstrated some improvements in evidence based practice skills and/or research knowledge translation, with three out of five studies demonstrating significant improvements. There is a paucity of empirical evidence supporting the best strategies to use in developing evidence based practice skills and/or research knowledge translation skills for Master's Nursing students. As a profession, nursing requires methodologically robust studies that are discipline specific to identify the best approaches for developing evidence-based practice skills and/or research knowledge translation skills within the university teaching environment. Provision of these strategies will enable the nursing profession to integrate the best empirical evidence into nursing practice. Copyright © 2018. Published by Elsevier Ltd.
The Roles of Pharmacy Schools in Bridging the Gap Between Law and Practice.
Adams, Alex J; Dering-Anderson, Allison; Klepser, Michael E; Klepser, Donald
2018-05-01
Progressive pharmacy laws do not always lead to progressive pharmacy practice. Progressive laws are necessary, but not sufficient for pharmacy services to take off in practice. Pharmacy schools can play critical roles by working collaboratively with community pharmacies to close the gap between law and practice. Our experiences launching pharmacy-based point-of-care testing services in community pharmacy settings illustrate some of the roles schools can play, including: developing and providing standardized training, developing template protocols, providing workflow support, sparking collaboration across pharmacies, providing policy support, and conducting research.
Interim report : a non-overlay cathodic protection system.
DOT National Transportation Integrated Search
1983-01-01
This interim report describes Virginia's experience in installing its first cathodic protection system for a bridge deck. The installation was completed with practically no problems. Very minor problems have been encountered with the rectifier/contro...
Boguta, Patrycja; Sokołowska, Zofia
2016-01-01
The main aim of this study was the analysis of the interaction between humic acids (HAs) from different soils and Zn(II) ions at wide concentration ranges and at two different pHs, 5 and 7, by using fluorescence and FTIR spectroscopy, as well as potentiometric measurements. The presence of a few areas of HAs structures responsible for Zn(II) complexing was revealed. Complexation at α-sites (low humified structures of low-molecular weight and aromatic polycondensation) and β-sites (weakly humified structures) was stronger at pH 7 than 5. This trend was not observed for γ-sites (structures with linearly-condensed aromatic rings, unsaturated bonds and large molecular weight). The amount of metal complexed at pH5 and 7 by α and γ-structures increased with a decrease in humification and aromaticity of HAs, contrary to β-areas where complexation increased with increasing content of carboxylic groups. The stability of complexes was higher at pH 7 and was the highest for γ-structures. At pH 5, stability decreased with C/N increase for α-areas and -COOH content increase for β-sites; stability increased with humification decrease for γ-structures. The stability of complexes at α and β-areas at pH 7 decreased with a drop in HAs humification. FTIR spectra at pH 5 revealed that the most-humified HAs tended to cause bidentate bridging coordination, while in the case of the least-humified HAs, Zn caused bidentate bridging coordination at low Zn additions and bidentate chelation at the highest Zn concentrations. Low Zn doses at pH 7 caused formation of unidentate complexes while higher Zn doses caused bidentate bridging. Such processes were noticed for HAs characterized by high oxidation degree and high oxygen functional group content; where these were low, HAs displayed bidentate bridging or even bidentate chelation. To summarize, the above studies have showed significant impact of Zn concentration, pH and some properties of HAs on complexation reactions of humic acids with zinc.
Boguta, Patrycja; Sokołowska, Zofia
2016-01-01
The main aim of this study was the analysis of the interaction between humic acids (HAs) from different soils and Zn(II) ions at wide concentration ranges and at two different pHs, 5 and 7, by using fluorescence and FTIR spectroscopy, as well as potentiometric measurements. The presence of a few areas of HAs structures responsible for Zn(II) complexing was revealed. Complexation at α-sites (low humified structures of low-molecular weight and aromatic polycondensation) and β-sites (weakly humified structures) was stronger at pH 7 than 5. This trend was not observed for γ-sites (structures with linearly-condensed aromatic rings, unsaturated bonds and large molecular weight). The amount of metal complexed at pH5 and 7 by α and γ-structures increased with a decrease in humification and aromaticity of HAs, contrary to β-areas where complexation increased with increasing content of carboxylic groups. The stability of complexes was higher at pH 7 and was the highest for γ-structures. At pH 5, stability decreased with C/N increase for α-areas and -COOH content increase for β-sites; stability increased with humification decrease for γ-structures. The stability of complexes at α and β-areas at pH 7 decreased with a drop in HAs humification. FTIR spectra at pH 5 revealed that the most-humified HAs tended to cause bidentate bridging coordination, while in the case of the least-humified HAs, Zn caused bidentate bridging coordination at low Zn additions and bidentate chelation at the highest Zn concentrations. Low Zn doses at pH 7 caused formation of unidentate complexes while higher Zn doses caused bidentate bridging. Such processes were noticed for HAs characterized by high oxidation degree and high oxygen functional group content; where these were low, HAs displayed bidentate bridging or even bidentate chelation. To summarize, the above studies have showed significant impact of Zn concentration, pH and some properties of HAs on complexation reactions of humic acids with zinc. PMID:27077915
Hybrid Discrete Element - Finite Element Simulation for Railway Bridge-Track Interaction
NASA Astrophysics Data System (ADS)
Kaewunruen, S.; Mirza, O.
2017-10-01
At the transition zone or sometimes called ‘bridge end’ or ‘bridge approach’, the stiffness difference between plain track and track over bridge often causes aggravated impact loading due to uneven train movement onto the area. The differential track settlement over the transition has been a classical problem in railway networks, especially for the aging rail infrastructures around the world. This problem is also additionally worsened by the fact that the construction practice over the area is difficult, resulting in a poor compaction of formation and subgrade. This paper presents an advanced hybrid simulation using coupled discrete elements and finite elements to investigate dynamic interaction at the transition zone. The goal is to evaluate the dynamic stresses and to better understand the impact dynamics redistribution at the bridge end. An existing bridge ‘Salt Pan Creek Railway Bridge’, located between Revesby and Kingsgrove, has been chosen for detailed investigation. The Salt Pan Bridge currently demonstrates crushing of the ballast causing significant deformation and damage. Thus, it’s imperative to assess the behaviours of the ballast under dynamic loads. This can be achieved by modelling the nonlinear interactions between the steel rail and sleeper, and sleeper to ballast. The continuum solid elements of track components have been modelled using finite element approach, while the granular media (i.e. ballast) have been simulated by discrete element method. The hybrid DE/FE model demonstrates that ballast experiences significant stresses at the contacts between the sleeper and concrete section. These overburden stress exists in the regions below the outer rails, identify fouling and permanent deformation of the ballast.
Connell, Louise A; McMahon, Naoimh E; Harris, Jocelyn E; Watkins, Caroline L; Eng, Janice J
2014-08-12
The Graded Repetitive Arm Supplementary Program (GRASP) is a hand and arm exercise programme designed to increase the intensity of exercise achieved in inpatient stroke rehabilitation. GRASP was shown to be effective in a randomised controlled trial in 2009 and has since experienced unusually rapid uptake into clinical practice. The aim of this study was to conduct a formative evaluation of the implementation of GRASP to inform the development and implementation of a similar intervention in the United Kingdom. Semi-structured interviews were conducted with therapists who were involved in implementing GRASP at their work site, or who had experience of using GRASP. Normalisation Process Theory (NPT), a sociological theory used to explore the processes of embedding innovations in practice, was used to develop an interview guide. Intervention components outlined within the GRASP Guideline Manual were used to develop prompts to explore how therapists use GRASP in practice. Interview transcripts were analysed using a coding frame based on implementation theory. Twenty interviews were conducted across eight sites in British Columbia Canada. Therapists identified informal networks and the free online availability of GRASP as key factors in finding out about the intervention. All therapists reported positive opinions about the value of GRASP. At all sites, therapists identified individuals who advocated for the use of GRASP, and in six of the eight sites this was the practice leader or senior therapist. Rehabilitation assistants were identified as instrumental in delivering GRASP in almost all sites as they were responsible for organising the GRASP equipment and assisting patients using GRASP. Almost all intervention components were found to be adapted to some degree when used in clinical practice; coverage was wider, the content adapted, and the dose, when monitored, was less. Although GRASP has translated into clinical practice, it is not always used in the way in which it was shown to be effective. This formative evaluation has informed the development of a novel intervention which aims to bridge this evidence-practice gap in upper limb rehabilitation after stroke.
Dose distribution for dental cone beam CT and its implication for defining a dose index
Pauwels, R; Theodorakou, C; Walker, A; Bosmans, H; Jacobs, R; Horner, K; Bogaerts, R
2012-01-01
Objectives To characterize the dose distribution for a range of cone beam CT (CBCT) units, investigating different field of view sizes, central and off-axis geometries, full or partial rotations of the X-ray tube and different clinically applied beam qualities. The implications of the dose distributions on the definition and practicality of a CBCT dose index were assessed. Methods Dose measurements on CBCT devices were performed by scanning cylindrical head-size water and polymethyl methacrylate phantoms, using thermoluminescent dosemeters, a small-volume ion chamber and radiochromic films. Results It was found that the dose distribution can be asymmetrical for dental CBCT exposures throughout a homogeneous phantom, owing to an asymmetrical positioning of the isocentre and/or partial rotation of the X-ray source. Furthermore, the scatter tail along the z-axis was found to have a distinct shape, generally resulting in a strong drop (90%) in absorbed dose outside the primary beam. Conclusions There is no optimal dose index available owing to the complicated exposure geometry of CBCT and the practical aspects of quality control measurements. Practical validation of different possible dose indices is needed, as well as the definition of conversion factors to patient dose. PMID:22752320
Meijs, Loek; Zusterzeel, Robbert; Wellens, Hein Jj; Gorgels, Anton Pm
With the passing of Dr. Galen Wagner, an exceptional collaboration between Maastricht University Medical Center, The Netherlands, and Duke Clinical Research Institute, USA, has come to an end. This article focuses on the background of what Galen coined the Maastricht-Duke bridge (MD-bridge), its merits, limitations and development throughout the years, and his special role. Between 2004 and 2015, 23 Maastricht University medical students and post-graduate students were enrolled in the 4-month research elective, mentored by Galen and the Maastricht co-mentor. They were asked to complete a survey about their MD-bridge experience. Sixteen out of the 23 students responded. None but 1 participant had prior research experience. Following their MD bridge-program most participants published 1 or more manuscripts and/or presented their research in an international setting. They felt they had full responsibility as a leader of their project with all participants developing meaningful skills useful in their current job. Fourteen out of 16 would recommend the MD-bridge experience to others. Participants considered the program of great value for their personal growth and independence, giving a feeling of achievement. In addition, for some participants it led to careers in foreign countries including medical practice and research, or obtaining PhDs. With Galen's impressive career of mentoring students, including the 23 MD-bridge participants, he has left behind an amazing concept of self-development in research and personal life. The successes of the MD-bridge prove that it is possible for students to be young investigators during or just after medical school with the potential to contribute to developing meaningful skills and noteworthy careers. Collaborations between international universities, such as the MD-bridge, are feasible and should be embraced by other institutions. Published by Elsevier Inc.
NASA Astrophysics Data System (ADS)
Talich, Milan
2017-12-01
The paper describes possibilities of the relatively new technics - ground based radar interferometry for precise determining of deformation of structures. Special focus on the vertical deflection of bridge structures and on the horizontal movements of high-rise buildings and structural objects is presented. The technology of ground based radar interferometry can be used in practice to the contactless determination of deformations of structures with accuracy up to 0.01 mm in real time. It is also possible in real time to capture oscillations of the object with a frequency up to 50 Hz. Deformations can be determined simultaneously in multiple places of the object, for example a bridge structure at points distributed on the bridge deck at intervals of one or more meters. This allows to obtain both overall and detailed information about the properties of the structure during the dynamic load and monitoring the impact of movements either individual vehicles or groups. In the case of high-rise buildings, it is possible to monitor the horizontal vibration of the whole object at its different height levels. It is possible to detect and determine the compound oscillations that occur in some types of buildings. Then prevent any damage or even disasters in these objects. In addition to the necessary theory basic principles of using radar interferometry for determining of deformation of structures are given. Practical examples of determining deformation of bridge structures, water towers reservoirs, factory chimneys and wind power plants are also given. The IBIS-S interferometric radar of the Italian IDS manufacturer was used for the measurements.
Teaching and physics education research: bridging the gap.
Fraser, James M; Timan, Anneke L; Miller, Kelly; Dowd, Jason E; Tucker, Laura; Mazur, Eric
2014-03-01
Physics faculty, experts in evidence-based research, often rely on anecdotal experience to guide their teaching practices. Adoption of research-based instructional strategies is surprisingly low, despite the large body of physics education research (PER) and strong dissemination effort of PER researchers and innovators. Evidence-based PER has validated specific non-traditional teaching practices, but many faculty raise valuable concerns toward their applicability. We address these concerns and identify future studies required to overcome the gap between research and practice.
Practical simplifications for radioimmunotherapy dosimetric models
DOE Office of Scientific and Technical Information (OSTI.GOV)
Shen, S.; DeNardo, G.L.; O`Donnell, R.T.
1999-01-01
Radiation dosimetry is potentially useful for assessment and prediction of efficacy and toxicity for radionuclide therapy. The usefulness of these dose estimates relies on the establishment of a dose-response model using accurate pharmacokinetic data and a radiation dosimetric model. Due to the complexity in radiation dose estimation, many practical simplifications have been introduced in the dosimetric modeling for clinical trials of radioimmunotherapy. Although research efforts are generally needed to improve the simplifications used at each stage of model development, practical simplifications are often possible for specific applications without significant consequences to the dose-response model. In the development of dosimetric methodsmore » for radioimmunotherapy, practical simplifications in the dosimetric models were introduced. This study evaluated the magnitude of uncertainty associated with practical simplifications for: (1) organ mass of the MIRD phantom; (2) radiation contribution from target alone; (3) interpolation of S value; (4) macroscopic tumor uniformity; and (5) fit of tumor pharmacokinetic data.« less
Clinical-academic partnerships research: converting the rhetoric into reality.
Happell, Brenda
2005-09-01
An increasing recognition of the importance of research-based practice to the nursing profession has led to a number of strategies designed to increase the utilization and conduct of nursing research. The transfer of nursing education from hospitals to universities occurred partly in response to the identified theory-practice gap. Subsequently, a significant investment in joint clinical-academic positions and clinical professorial positions has been made with the intention of bridging the gap between the tertiary sector and the clinical field. Anecdotal evidence suggests that neither strategy has achieved the desired degree of success. The available literature suggests that nurses do not tend to become involved in the conduct of research, nor do they readily utilise research findings in their practice. It is hypothesized in this paper that this reflects the strong cultural differences between the clinical and academic worlds in nursing. The aim of this paper is to discuss the impact of these cultural differences and describe specific principals that could contribute to significant cultural change and the bridging of the academic-clinician divide.
77 FR 19954 - Special Local Regulations for Marine Events, Swim Event, Lake Gaston; Littleton, NC
Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-03
..., and swimming north along the western side of Eaton Ferry Bridge to the Waterview Restaurant. A fleet..., design, or operation; test methods; sampling procedures; and related management systems practices) that...
Am I at Risk? | NIH MedlinePlus the Magazine
... More Breathe Better ® program seeks to: Bridge the gap between research and practice to: Educate healthcare providers on the benefits of early diagnosis and appropriate selection of treatment options. Provide empowering calls to action ...
eHealth and IMIA's Strategic Planning Process - IMIA conference introductory address.
Murray, Peter; Haux, Reinhold; Lorenzi, Nancy
2008-01-01
The International Medical Informatics Association (IMIA) is the only organization in health and biomedical informatics which is fully international in scope, bridging the academic, health practice, education, and health industry worlds through conferences, working groups, special interest groups and publications. Authored by the IMIA Interim Vice President for Strategic Planning Implementation and co-authored by the current IMIA President and the IMIA Past-President, the intention of this paper is to introduce IMIA's current strategic planning process and to set this process in relation to 'eHealth: Combining Health Telematics, Telemedicine, Biomedical Engineering and Bioinformatics to the Edge', the theme of this conference. From the viewpoint of an international organization such as IMIA, an eHealth strategy needs to be considered in a comprehensive way, including broadly stimulating high-quality health and biomedical informatics research and education, as well as providing support to bridging outcomes towards a new practice of health care in a changing world.
Liberating minds: Consciousness-raising as a bridge between feminism and psychology in 1970s Canada.
Ruck, Nora
2015-08-01
This article examines the interrelations between psychology and feminism in the work of feminist psychologists and radical feminists in Toronto in the early 1970s. For Canadian feminist psychology as well as for second-wave activism, Toronto was a particular hotspot. It was the academic home of some of the first Canadian feminist psychologists, and was the site of a lively scene of feminists working in established women's organizations along with younger socialist and radical feminists. This article analyzes the interrelations of academic feminist psychology and feminist activism by focusing on consciousness-raising, a practice that promised to bridge tensions between the personal and the political, psychological and social liberation, everyday knowledge and institutionalized knowledge production, theory and practice, as well as the women's movement and other spheres of women's lives. (c) 2015 APA, all rights reserved).
Case Studies in Exercise and Sport Sciences: A Powerful Tool to Bridge the Science-Practice Gap.
Halperin, Israel
2018-03-27
Despite the progress made by the scientific exercise community in collaborating and communicating with non-scientist coaches, there is room for improvement. Coaches find research difficult to understand, feel that their interests are not being addressed by exercise research, and rely on peer-discussion to further their coaching knowledge base while consuming little peer-reviewed articles. One useful strategy to bridge the science-practice gap is with case-studies. In addition to furthering our understanding of the physiology, psychology, and training schedules of elite athletes, case studies can serve 1) as a useful communication channel with coaches if presented as narratives and 2) to establish and strengthen relationships between scientists and coaches leading to fruitful research collaborations. The purpose of this invited commentary is to discuss these two less-recognized benefits of case-studies, and propose a way to incorporate case-studies more frequently alongside group-based studies.
Case Studies in Exercise and Sport Sciences: A Powerful Tool to Bridge the Science-Practice Gap.
Halperin, Israel
2018-06-21
Despite the progress made by the scientific exercise community in collaborating and communicating with nonscientist coaches, there is room for improvement. Coaches find research difficult to understand, feel that their interests are not being addressed by exercise research, and rely on peer discussion to further their coaching knowledge base while consuming few peer-reviewed articles. One useful strategy to bridge the science-practice gap is with case studies. In addition to furthering our understanding of the physiology, psychology, and training schedules of elite athletes, case studies can serve (1) as a useful communication channel with coaches if presented as narratives and (2) to establish and strengthen relationships between scientists and coaches, leading to fruitful research collaborations. The purpose of this invited commentary is to discuss these 2 less-recognized benefits of case studies and propose a way to incorporate case studies more frequently alongside group-based studies.
Documenting the doable and doing the documented: bridging strategies at the UK Stem Cell Bank.
Stephens, Neil; Atkinson, Paul; Glasner, Peter
2011-12-01
We explore the local negotiation of regulatory practice at the UK Stem Cell Bank, the first Bank of its type in the world. Basing our empirical work on a detailed analysis of one aspect of the Bank's regulatory commitment--the completion of the Cell Line Information form--we make visible the necessary judgements and labour involved in interpreting and operationalizing externally imposed regulation. The discussion opens by detailing the problems encountered when the Bank completes the form: reconciling a bureaucratic system of accountability with craft-like laboratory skills involving multiple kinds of tacit knowledge. We follow this by explicating the emergent 'bridging strategies' pursued by the Bank to address these issues, highlighting their reliance upon the formation of trust and social networks. The closing discussion emphasizes the contingent assembly of regulatory practices that emerge in the local setting.
DNA-bridged Chiroplasmonic Assemblies of Nanoparticles
NASA Astrophysics Data System (ADS)
Kotov, Nicholas
2015-03-01
Chirality at nanoscale attracts a lot of attention during the last decade. A number of chiral nanoscale systems had been discovered ranging from individual nanoparticles to helical nanowires and from lithographically defined substrates. DNA bridges make possible in-silico engineering and practical construction of complex assemblies of nanoparticles with of both plasmonic and excitonic nature. In this presentation, expected and unexpected optical effects that we observed in chiral plasmonic and excitonic systems will be demonstrated. Special effort will be placed on the transitioning of theoretical and experimental knowledge about chiral nanoscale systems to applications. The most obvious direction for practical targets was so far, the design of metamaterials for negative refractive index optics. The results describing the 3D materials with the highest experimentally observed chiral anisotropy factor will be presented. It will be followed by the discussion of the recent developments in analytical application of chiral assemblies for detection of cancer and bacterial contamination.
Workload Intensity, The Nursing Practice Environment, and Adverse Events
2014-01-05
February). Are nursing outcome databases sensitive to outcome changes overtime ?, Southern Nursing Research Society 26th Annual Conference, New...FINAL 3. DATES COVERED (From - To) 1 SEP 2010- 31 AUG 2014 4. TITLE AND SUBTITLE Workload Intensity, the Nursing Practice Environment, and...10. SPONSOR/MONITOR’S ACRONYM(S) TriService Nursing Research TSNRP Program, 4301 Jones Bridge RD Bethesda, MD 20814 11. SPONSOR/MONITOR’S
ERIC Educational Resources Information Center
Walker, Bridget; Clancy, Michaela; Tsai, Shu-Fei; Cheney, Doug
2013-01-01
In the past few years researchers have published lists of evidence-based practices that research indicates "should" be in place in programs and supports for students with emotional or behavioral disorders (EBD) (e.g., Farley, Torres, Wailehua, & Cook, 2012; Ryan, Pierce, & Mooney, 2008; Simpson, Peterson, & Smith, 2011). Some…
ERIC Educational Resources Information Center
Herzog, Walter
2003-01-01
Considers the mediation between scientific knowledge and practical action as a crucial feature of professional teaching. Investigates the assumption that typologies represent a form of knowledge which can bridge the gap between theory and practice. Differentiates between two forms of typological thinking and discusses reservations concerning…
ERIC Educational Resources Information Center
Dustin, Daniel L.; Schwab, Keri A.; Hendricks, William W.
2016-01-01
In this paper we discuss the intractability of the "great divide" between higher education and professional practice in parks, recreation, and tourism. We begin by drawing parallels between our field and other professional fields to demonstrate that the issue is not ours alone; indeed, it is common to most professional fields. We then…
ERIC Educational Resources Information Center
Brion-Meisels, Gretchen; Garnett, Bernice Raveche
2016-01-01
Despite an increased interest in bullying prevention programming over the last 10 years, significant gaps remain among theory, research, and practice in this critical area of school psychology. This article argues that the current Centers for Disease Control and Prevention (CDC) definition of bullying does not fully capture the experiences of many…
ERIC Educational Resources Information Center
Kahn, Sarah Zeta
2013-01-01
The purpose of this study was to increase the current understanding of what occurs within a narrative supervision process and to explore how this approach to supervision can contribute to the development of educational practices that promote social justice efforts in the field of marriage and family therapy. In particular, this study sought to…
ERIC Educational Resources Information Center
Yoder, Nicholas
2014-01-01
Teachers help promote the social and emotional learning skills students need to be college and career ready, such as collaborating with others, monitoring their own behavior, and making responsible decisions. Social-emotional learning (SEL) is critical to the introduction of college and career readiness standards. To bridge the connection between…
ERIC Educational Resources Information Center
van Ingen, Sarah; Alvarez McHatton, Patricia; Vomvoridi-Ivanovic, Eugenia
2016-01-01
Despite widespread discourse about the need for teachers to utilize education research, little is known about how teachers learn to engage in this practice. How do preservice teachers understand the use of research to inform their teaching? Set within the context of a mathematics methods course, this study provides a detailed analysis of the…
Xu, Zhijing; Zu, Zhenghu; Zheng, Tao; Zhang, Wendou; Xu, Qing; Liu, Jinjie
2014-01-01
The high incidence of emerging infectious diseases has highlighted the importance of effective immunization strategies, especially the stochastic algorithms based on local available network information. Present stochastic strategies are mainly evaluated based on classical network models, such as scale-free networks and small-world networks, and thus are insufficient. Three frequently referred stochastic immunization strategies-acquaintance immunization, community-bridge immunization, and ring vaccination-were analyzed in this work. The optimal immunization ratios for acquaintance immunization and community-bridge immunization strategies were investigated, and the effectiveness of these three strategies in controlling the spreading of epidemics were analyzed based on realistic social contact networks. The results show all the strategies have decreased the coverage of the epidemics compared to baseline scenario (no control measures). However the effectiveness of acquaintance immunization and community-bridge immunization are very limited, with acquaintance immunization slightly outperforming community-bridge immunization. Ring vaccination significantly outperforms acquaintance immunization and community-bridge immunization, and the sensitivity analysis shows it could be applied to controlling the epidemics with a wide infectivity spectrum. The effectiveness of several classical stochastic immunization strategies was evaluated based on realistic contact networks for the first time in this study. These results could have important significance for epidemic control research and practice.
Breadth-First Search-Based Single-Phase Algorithms for Bridge Detection in Wireless Sensor Networks
Akram, Vahid Khalilpour; Dagdeviren, Orhan
2013-01-01
Wireless sensor networks (WSNs) are promising technologies for exploring harsh environments, such as oceans, wild forests, volcanic regions and outer space. Since sensor nodes may have limited transmission range, application packets may be transmitted by multi-hop communication. Thus, connectivity is a very important issue. A bridge is a critical edge whose removal breaks the connectivity of the network. Hence, it is crucial to detect bridges and take preventions. Since sensor nodes are battery-powered, services running on nodes should consume low energy. In this paper, we propose energy-efficient and distributed bridge detection algorithms for WSNs. Our algorithms run single phase and they are integrated with the Breadth-First Search (BFS) algorithm, which is a popular routing algorithm. Our first algorithm is an extended version of Milic's algorithm, which is designed to reduce the message length. Our second algorithm is novel and uses ancestral knowledge to detect bridges. We explain the operation of the algorithms, analyze their proof of correctness, message, time, space and computational complexities. To evaluate practical importance, we provide testbed experiments and extensive simulations. We show that our proposed algorithms provide less resource consumption, and the energy savings of our algorithms are up by 5.5-times. PMID:23845930
Identification of unusual events in multi-channel bridge monitoring data
NASA Astrophysics Data System (ADS)
Omenzetter, Piotr; Brownjohn, James Mark William; Moyo, Pilate
2004-03-01
Continuously operating instrumented structural health monitoring (SHM) systems are becoming a practical alternative to replace visual inspection for assessment of condition and soundness of civil infrastructure such as bridges. However, converting large amounts of data from an SHM system into usable information is a great challenge to which special signal processing techniques must be applied. This study is devoted to identification of abrupt, anomalous and potentially onerous events in the time histories of static, hourly sampled strains recorded by a multi-sensor SHM system installed in a major bridge structure and operating continuously for a long time. Such events may result, among other causes, from sudden settlement of foundation, ground movement, excessive traffic load or failure of post-tensioning cables. A method of outlier detection in multivariate data has been applied to the problem of finding and localising sudden events in the strain data. For sharp discrimination of abrupt strain changes from slowly varying ones wavelet transform has been used. The proposed method has been successfully tested using known events recorded during construction of the bridge, and later effectively used for detection of anomalous post-construction events.
Veth, Klaske N.; Van der Heijden, Beatrice I. J. M.; Korzilius, Hubert P. L. M.; De Lange, Annet H.; Emans, Ben J. M.
2018-01-01
This two-wave complete panel study aims to examine human resource management (HRM) bundles of practices in relation to social support [i.e., leader–member exchange (LMX), coworker exchange (CWX)] and employee outcomes (i.e., work engagement, employability, and health), within a context of workers aged 65+. Based upon the social exchange theory and the Job Demands-Resources (JD-R) framework, it was hypothesized that HRM bundles at Time 1 would increase bridge workers' outcomes at Time 2, and that this relationship would be mediated by perceptions of LMX and CWX at Time 2. Using a longitudinal design, hypotheses were tested in a unique sample of Dutch bridge employees (N = 228). Results of several structural equation modeling analyses revealed no significant associations between HRM bundles, and social support, moreover, no significant associations were found in relation to employee outcomes. However, the results of the best-fitting final model revealed the importance of the impact of social support on employee (65+) outcomes over time. PMID:29755386
Bridging In-school and Out-of-school Learning: Formal, Non-Formal, and Informal Education
NASA Astrophysics Data System (ADS)
Eshach, Haim
2007-04-01
The present paper thoroughly examines how one can effectively bridge in-school and out-of-school learning. The first part discusses the difficulty in defining out-of-school learning. It proposes to distinguish three types of learning: formal, informal, and non-formal. The second part raises the question of whether out-of-school learning should be dealt with in the in-school system, in view of the fact that we experience informal learning anyway as well as considering the disadvantages and difficulties teachers are confronted with when planning and carrying out scientific fieldtrips. The voices of the teachers, the students, and the non-formal institution staff are heard to provide insights into the problem. The third part discusses the cognitive and affective aspects of non-formal learning. The fourth part presents some models explaining scientific fieldtrip learning and based on those models, suggests a novel explanation. The fifth part offers some recommendations of how to bridge in and out-of-school learning. The paper closes with some practical ideas as to how one can bring the theory described in the paper into practice. It is hoped that this paper will provide educators with an insight so that they will be able to fully exploit the great potential that scientific field trips may offer.
Molony, Julia T; Monda, Keri L; Li, Suying; Beaubrun, Anne C; Gilbertson, David T; Bradbury, Brian D; Collins, Allan J
2016-08-01
Little is known about epoetin alfa (EPO) dosing at dialysis centers after implementation of the US Medicare prospective payment system and revision of the EPO label in 2011. Retrospective cohort study. Approximately 412,000 adult hemodialysis patients with Medicare Parts A and B as primary payer in 2009 to 2012 to describe EPO dosing and hemoglobin patterns; of these, about 70,000 patients clustered in about 1,300 dialysis facilities to evaluate facility-level EPO titration practices and patient-level outcomes in 2012. Facility EPO titration practices when hemoglobin levels were <10 and >11g/dL (grouped treatment variable) determined from monthly EPO dosing and hemoglobin level patterns. Patient mean hemoglobin levels, red blood cell transfusion rates, and all-cause and cause-specific hospitalization rates using a facility-based analysis. Monthly EPO dose and hemoglobin level, red blood cell transfusion rates, and all-cause and cause-specific hospitalization rates. Monthly EPO doses declined across all hemoglobin levels, with the greatest decline in patients with hemoglobin levels < 10g/dL (July-October 2011). In 2012, nine distinct facility titration practices were identified. Across groups, mean hemoglobin levels differed slightly (10.5-10.8g/dL) but within-patient hemoglobin standard deviations were similar (∼0.68g/dL). Patients at facilities implementing greater dose reductions and smaller dose escalations had lower hemoglobin levels and higher transfusion rates. In contrast, patients at facilities that implemented greater dose escalations (and large or small dose reductions) had higher hemoglobin levels and lower transfusion rates. There were no clinically meaningful differences in all-cause or cause-specific hospitalization events across groups. Possibly incomplete claims data; excluded small facilities and those without consistent titration patterns; hemoglobin levels reported monthly; inferred facility practice from observed dosing. Following prospective payment system implementation and labeling revisions, EPO doses declined significantly. Under the new label, facility EPO titration practices were associated with mean hemoglobin levels (but not standard deviations) and transfusion use, but not hospitalization rates. Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
Bridging the gap: a review of dose investigations in paediatric investigation plans
Hampson, Lisa V; Herold, Ralf; Posch, Martin; Saperia, Julia; Whitehead, Anne
2014-01-01
Aims In the EU, development of new medicines for children should follow a prospectively agreed paediatric investigation plan (PIP). Finding the right dose for children is crucial but challenging due to the variability of pharmacokinetics across age groups and the limited sample sizes available. We examined strategies adopted in PIPs to support paediatric dosing recommendations to identify common assumptions underlying dose investigations and the attempts planned to verify them in children. Methods We extracted data from 73 PIP opinions recently adopted by the Paediatric Committee of the European Medicines Agency. These opinions represented 79 medicinal development programmes and comprised a total of 97 dose investigation studies. We identified the design of these dose investigation studies, recorded the analyses planned and determined the criteria used to define target doses. Results Most dose investigation studies are clinical trials (83 of 97) that evaluate a single dosing rule. Sample sizes used to investigate dose are highly variable across programmes, with smaller numbers used in younger children (< 2 years). Many studies (40 of 97) do not pre-specify a target dose criterion. Of those that do, most (33 of 57 studies) guide decisions using pharmacokinetic data alone. Conclusions Common assumptions underlying dose investigation strategies include dose proportionality and similar exposure−response relationships in adults and children. Few development programmes pre-specify steps to verify assumptions in children. There is scope for the use of Bayesian methods as a framework for synthesizing existing information to quantify prior uncertainty about assumptions. This process can inform the design of optimal drug development strategies. PMID:24720849
Assessing potential scour using the South Carolina bridge-scour envelope curves
Benedict, Stephen T.; Feaster, Toby D.; Caldwell, Andral W.
2016-09-30
SummaryBridge-scour equations presented in the Federal Highway Administration Hydraulic Engineering Circular No. 18 reflect the current state-of-the practice for predicting scour at bridges. Although these laboratory-derived equations provide an important resource for assessing scour potential, there is a measure of uncertainty when applying these equations to field conditions. The uncertainty and limitations have been acknowledged by laboratory researchers and confirmed in field investigations.Because of the uncertainty associated with bridge-scour equations, HEC-18 recommends that engineers evaluate the computed scour depths obtained from the equations and modify the resulting data if they appear unreasonable. Perhaps the best way to evaluate the reasonableness of predicted scour is to compare it to field measurements of historic scour. Historic field data show scour depths resulting from high flows and provide a reference for evaluating predicted scour. It is rare, however, that such data are available at or near a site of interest, making the evaluation of predicted scour as compared to field data difficult if not impossible. Realizing the value of historic scour measurements, the U.S. Geological Survey (USGS), in cooperation with the South Carolina Department of Transportation (SCDOT), conducted a series of three field investigations to collect historic scour data with the goal of understanding regional trends of scour at riverine bridges in South Carolina.Historic scour measurements, including measurements of clear-water abutment, contraction, and pier scour, as well as live-bed contraction and pier scour, were made at more than 200 bridges. These field investigations provided valuable insights into regional scour trends and yielded regional bridge-scour envelope curves that can be used as supplementary tools for assessing all components of scour at riverine bridges in South Carolina.The application and limitations of these envelope curves were documented in four reports. Because each report addresses different components of bridge scour, it was recognized that there was a need to develop an integrated procedure for applying the envelope curves to help assess scour potential at riverine bridges in South Carolina. The result of that effort is detailed in Benedict and others (2016) and summarized in this fact sheet.
Simultaneously optimizing dose and schedule of a new cytotoxic agent.
Braun, Thomas M; Thall, Peter F; Nguyen, Hoang; de Lima, Marcos
2007-01-01
Traditionally, phase I clinical trial designs are based upon one predefined course of treatment while varying among patients the dose given at each administration. In actual medical practice, patients receive a schedule comprised of several courses of treatment, and some patients may receive one or more dose reductions or delays during treatment. Consequently, the overall risk of toxicity for each patient is a function of both actual schedule of treatment and the differing doses used at each adminstration. Our goal is to provide a practical phase I clinical trial design that more accurately reflects actual medical practice by accounting for both dose per administration and schedule. We propose an outcome-adaptive Bayesian design that simultaneously optimizes both dose and schedule in terms of the overall risk of toxicity, based on time-to-toxicity outcomes. We use computer simulation as a tool to calibrate design parameters. We describe a phase I trial in allogeneic bone marrow transplantation that was designed and is currently being conducted using our new method. Our computer simulations demonstrate that our method outperforms any method that searches for an optimal dose but does not allow schedule to vary, both in terms of the probability of identifying optimal (dose, schedule) combinations, and the numbers of patients assigned to those combinations in the trial. Our design requires greater sample sizes than those seen in traditional phase I studies due to the larger number of treatment combinations examined. Our design also assumes that the effects of multiple administrations are independent of each other and that the hazard of toxicity is the same for all administrations. Our design is the first for phase I clinical trials that is sufficiently flexible and practical to truly reflect clinical practice by varying both dose and the timing and number of administrations given to each patient.
Design criteria for post and beam bents with drilled shafts.
DOT National Transportation Integrated Search
2007-12-01
The research work presented in the report addresses the potential areas of conservatism in the current practice related to bridge : bents supported by drilled shafts and piles. The research encompasses modeling efforts and an experimental program. Mo...
Rural roads and bridges : management issues facing local highway officials
DOT National Transportation Integrated Search
1996-09-01
The report documents management practices used by, and issues facing, local transportation administrators. Data are drawn from a national survey of county and town highway officials, in Fall 1994 and Spring 1995, which provided usable information fro...
Best Manufacturing Practices Survey Conducted at Litton Data Systems Division, Van Nuys, California
1988-10-01
Hardware and Software ................................ 10 DESIGN RELEASE Engineering Change Order Processing and Analysis...structured using bridges to isolate local traffic. Long term plans call for a wide-band network. ENGINEERING CHANGE ORDER PROCESSING AND ANALYSIS
MTSS Coaching: Bridging Knowing to Doing
ERIC Educational Resources Information Center
Freeman, Jennifer; Sugai, George; Simonsen, Brandi; Everett, Susannah
2017-01-01
Improving educator effectiveness and school functioning requires continuous attention to practice selection, implementation fidelity, and progress monitoring, especially in the context of systemic school reform efforts. As such, supporting professional development must be targeted, comprehensive, efficient, and relevant. In particular, coaching…
Prototypes for Content-Based Image Retrieval in Clinical Practice
Depeursinge, Adrien; Fischer, Benedikt; Müller, Henning; Deserno, Thomas M
2011-01-01
Content-based image retrieval (CBIR) has been proposed as key technology for computer-aided diagnostics (CAD). This paper reviews the state of the art and future challenges in CBIR for CAD applied to clinical practice. We define applicability to clinical practice by having recently demonstrated the CBIR system on one of the CAD demonstration workshops held at international conferences, such as SPIE Medical Imaging, CARS, SIIM, RSNA, and IEEE ISBI. From 2009 to 2011, the programs of CADdemo@CARS and the CAD Demonstration Workshop at SPIE Medical Imaging were sought for the key word “retrieval” in the title. The systems identified were analyzed and compared according to the hierarchy of gaps for CBIR systems. In total, 70 software demonstrations were analyzed. 5 systems were identified meeting the criterions. The fields of application are (i) bone age assessment, (ii) bone fractures, (iii) interstitial lung diseases, and (iv) mammography. Bridging the particular gaps of semantics, feature extraction, feature structure, and evaluation have been addressed most frequently. In specific application domains, CBIR technology is available for clinical practice. While system development has mainly focused on bridging content and feature gaps, performance and usability have become increasingly important. The evaluation must be based on a larger set of reference data, and workflow integration must be achieved before CBIR-CAD is really established in clinical practice. PMID:21892374
Griffiths, Roland R; Johnson, Matthew W; Richards, William A; Richards, Brian D; Jesse, Robert; MacLean, Katherine A; Barrett, Frederick S; Cosimano, Mary P; Klinedinst, Maggie A
2018-01-01
Psilocybin can occasion mystical-type experiences with participant-attributed increases in well-being. However, little research has examined enduring changes in traits. This study administered psilocybin to participants who undertook a program of meditation/spiritual practices. Healthy participants were randomized to three groups (25 each): (1) very low-dose (1 mg/70 kg on sessions 1 and 2) with moderate-level ("standard") support for spiritual-practice (LD-SS); (2) high-dose (20 and 30 mg/70 kg on sessions 1 and 2, respectively) with standard support (HD-SS); and (3) high-dose (20 and 30 mg/70kg on sessions 1 and 2, respectively) with high support for spiritual practice (HD-HS). Psilocybin was administered double-blind and instructions to participants/staff minimized expectancy confounds. Psilocybin was administered 1 and 2 months after spiritual-practice initiation. Outcomes at 6 months included rates of spiritual practice and persisting effects of psilocybin. Compared with low-dose, high-dose psilocybin produced greater acute and persisting effects. At 6 months, compared with LD-SS, both high-dose groups showed large significant positive changes on longitudinal measures of interpersonal closeness, gratitude, life meaning/purpose, forgiveness, death transcendence, daily spiritual experiences, religious faith and coping, and community observer ratings. Determinants of enduring effects were psilocybin-occasioned mystical-type experience and rates of meditation/spiritual practices. Psilocybin can occasion enduring trait-level increases in prosocial attitudes/behaviors and in healthy psychological functioning. Trial Registration ClinicalTrials.gov Identifier NCT00802282.
Griffiths, Roland R; Johnson, Matthew W; Richards, William A; Richards, Brian D; Jesse, Robert; MacLean, Katherine A; Barrett, Frederick S; Cosimano, Mary P; Klinedinst, Maggie A
2017-01-01
Psilocybin can occasion mystical-type experiences with participant-attributed increases in well-being. However, little research has examined enduring changes in traits. This study administered psilocybin to participants who undertook a program of meditation/spiritual practices. Healthy participants were randomized to three groups (25 each): (1) very low-dose (1 mg/70 kg on sessions 1 and 2) with moderate-level (“standard”) support for spiritual-practice (LD-SS); (2) high-dose (20 and 30 mg/70 kg on sessions 1 and 2, respectively) with standard support (HD-SS); and (3) high-dose (20 and 30 mg/70kg on sessions 1 and 2, respectively) with high support for spiritual practice (HD-HS). Psilocybin was administered double-blind and instructions to participants/staff minimized expectancy confounds. Psilocybin was administered 1 and 2 months after spiritual-practice initiation. Outcomes at 6 months included rates of spiritual practice and persisting effects of psilocybin. Compared with low-dose, high-dose psilocybin produced greater acute and persisting effects. At 6 months, compared with LD-SS, both high-dose groups showed large significant positive changes on longitudinal measures of interpersonal closeness, gratitude, life meaning/purpose, forgiveness, death transcendence, daily spiritual experiences, religious faith and coping, and community observer ratings. Determinants of enduring effects were psilocybin-occasioned mystical-type experience and rates of meditation/spiritual practices. Psilocybin can occasion enduring trait-level increases in prosocial attitudes/behaviors and in healthy psychological functioning. Trial Registration ClinicalTrials.gov Identifier NCT00802282 PMID:29020861
Results of celiac trunk stenting during fenestrated or branched aortic endografting.
Wattez, Hélène; Martin-Gonzalez, Teresa; Lopez, Benjamin; Spear, Rafaëlle; Clough, Rachel E; Hertault, Adrien; Sobocinski, Jonathan; Haulon, Stéphan
2016-12-01
Endovascular repair of aortic aneurysms involving the visceral segment of the aorta often requires placement of a covered bridging stent in the celiac axis (CA). The median arcuate ligament (MAL) is a fibrous arch that unites the diaphragmatic crura on either side of the aortic hiatus. The ligament may compress and distort the celiac artery and result in difficult cannulation, or stenosis and occlusion of the vessel. This study evaluated the influence of the MAL compression on the technical success and the patency of the celiac artery after branched and fenestrated endovascular aortic repair. We retrospectively analyzed a cohort of consecutive patients treated electively for complex aneurysms with branched and fenestrated endovascular aortic repair between January 2007 and April 2014. All data were collected prospectively. Analysis of preoperative computed tomography angiography on a three-dimensional workstation determined the presence of MAL compression. Patency of the CA bridging stent was assessed during follow-up by computed tomography angiography and duplex ultrasound evaluation. Statistical analysis was performed to compare the outcomes of patients with MAL (MAL+) and without MAL (MAL-) compression. Of 315 patients treated for aortic disease involving the visceral segment during the study period, 113 had endografts designed with a branch (n = 57) or fenestration (n = 56) for the CA. In 45 patients (39.8%), asymptomatic compression of the CA by the MAL was depicted (MAL+). Complex endovascular techniques were required in this group to access the CA in 16 (14.2%) patients (vs none in the MAL- group; P = .003), which lead to a failed bridging stent implantation in seven patients (6.2%). Increased operative time and dose area product were observed in the MAL+ group, but this did not reach statistical significance. In the MAL+ group, no thrombosis of the CA bridging stents were observed during follow-up; an external compression of the CA bridging stent was depicted in six patients but without hemodynamic effect on duplex ultrasound imaging. In the MAL- group, one CA bridging stent occlusion occurred owing to an embolus from a cardiac source. MAL compression is associated with good celiac trunk bridging stent patency during follow-up, but with a higher rate of technical difficulties and failed bridging stent implantation during the procedure. Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.
Wilcox, Sara; Altpeter, Mary; Anderson, Lynda A.; Belza, Basia; Bryant, Lucinda; Jones, Dina L.; Leith, Katherine H.; Phelan, Elizabeth A.; Satariano, William A.
2015-01-01
There is an urgent need to translate science into practice and help enhance the capacity of professionals to deliver evidence-based programming. We describe contributions of the Healthy Aging Research Network in building professional capacity through online modules, issue briefs, monographs, and tools focused on health promotion practice, physical activity, mental health, and environment and policy. We also describe practice partnerships and research activities that helped inform product development and ways these products have been incorporated into real-world practice to illustrate possibilities for future applications. Our work aims to bridge the research-to-practice gap to meet the demands of an aging population. PMID:24000962
Closing the chasm between research and practice: evidence of and for change.
Green, Lawrence W
2014-04-01
The usual remedy suggested for bridging the science-to-practice gap is to improve the efficiency of disseminating the evidence-based practices to practitioners. This reflection on the gap takes the position that it is the relevance and fit of the evidence with the majority of practices that limit its applicability and application in health promotion and related behavioural, community and population-level interventions where variations in context, values and norms make uniform interventions inappropriate. To make the evidence more relevant and actionable to practice settings and populations will require reforms at many points in the research-to-practice pipeline. These points in the pipeline are described and remedies for them suggested.
Epoxy coated reinforcement in bridge decks
NASA Astrophysics Data System (ADS)
Wills, J.
A review was conducted of methods relating to the use of epoxy coated reinforcing bars for bridge decks and their potential for use in the United Kingdom. A survey of work carried out in the USA was carried out and the analysis used in a preliminary cost study. The options of having either a hot rolled asphalt surfacing or a permanently exposed concrete wearing surface were considered. It was concluded that epoxy coating of the top steel in addition to current waterproofing practice would provide, at relatively little extra cost, additional assurance that the reinforcement would be adequately protected throughout the life of a bridge. Current design rules do not permit decks with permanently exposed concrete wearing surface without waterproofing. Epoxy coating may afford a means of introducing such decks but before a positive recommendation to delete waterproofing can be made further studies would have to be undertaken.
Energy economy in the actomyosin interaction: lessons from simple models.
Lehman, Steven L
2010-01-01
The energy economy of the actomyosin interaction in skeletal muscle is both scientifically fascinating and practically important. This chapter demonstrates how simple cross-bridge models have guided research regarding the energy economy of skeletal muscle. Parameter variation on a very simple two-state strain-dependent model shows that early events in the actomyosin interaction strongly influence energy efficiency, and late events determine maximum shortening velocity. Addition of a weakly-bound state preceding force production allows weak coupling of cross-bridge mechanics and ATP turnover, so that a simple three-state model can simulate the velocity-dependence of ATP turnover. Consideration of the limitations of this model leads to a review of recent evidence regarding the relationship between ligand binding states, conformational states, and macromolecular structures of myosin cross-bridges. Investigation of the fine structure of the actomyosin interaction during the working stroke continues to inform fundamental research regarding the energy economy of striated muscle.
NASA Astrophysics Data System (ADS)
Crossley, Michael
2008-07-01
Addressing the central theme of the XIII World Congress, the paper explores a number of contemporary theoretical, methodological and organisational developments in the field of comparative education. In doing so it draws upon the author's recent work and a selection of studies carried out in the South Pacific, the Caribbean and Africa. It is argued that disciplined comparative and international research can contribute much to the development of theory and methodology - as well as to the improvement of policy and practice in education world-wide. For this to be realised it is maintained that ongoing efforts to challenge and `reconceptualise' the field deserve sustained support - and increased attention to a more effective `bridging of cultures and traditions'. This `bridging' thesis is examined in greater depth, pointing to possible ways forward for those engaged in advancing the future of comparative research in education and in the social sciences more generally.
Kutkut, Ahmad; Abu-Hammad, Osama; Frazer, Robert
2016-01-01
Impression techniques for implant restorations can be implant level or abutment level impressions with open tray or closed tray techniques. Conventional implant-abutment level impression techniques are predictable for maximizing esthetic outcomes. Restoration of the implant traditionally requires the use of the metal or plastic impression copings, analogs, and laboratory components. Simplifying the dental implant restoration by reducing armamentarium through incorporating conventional techniques used daily for crowns and bridges will allow more general dentists to restore implants in their practices. The demonstrated technique is useful when modifications to implant abutments are required to correct the angulation of malpositioned implants. This technique utilizes conventional crown and bridge impression techniques. As an added benefit, it reduces costs by utilizing techniques used daily for crowns and bridges. The aim of this report is to describe a simplified conventional impression technique for custom abutments and modified prefabricated solid abutments for definitive restorations. PMID:29563457
ERIC Educational Resources Information Center
Kamiya, Nobuhiro
2012-01-01
A call for a bridge between research and practice is nothing new, yet it seems to be an impossible task to accomplish. Despite the dedicated efforts made by numerous researchers in the past, the world is still largely separate between researchers and teachers. One piece of evidence is that research studies seem to have only a little impact on…
Giuliano, Karen K
2003-04-01
The philosophy of Aristotle and its impact on the process of empirical scientific inquiry has been substantial. The influence of the clarity and orderliness of his thinking, when applied to the acquisition of knowledge in nursing, can not be overstated. Traditional empirical approaches have and will continue to have an important influence on the development of nursing knowledge through nursing research. However, as nursing is primarily a practice discipline, the transition from empirical and syllogistic reasoning is problematic. Other types of inquiry are essential in the application of nursing knowledge obtained by empirical scientific approaches and to understand how that knowledge can best be used in the care of patients. This paper reviews the strengths and limitations of syllogistic reasoning by applying it to a recently published study on temperature measurement in nursing. It then discusses possible ways that the empirical knowledge gained from that study and confirmed in its reasoning by logical analysis could be used in the daily care of critically ill patients. It concludes by highlighting the utility of broader approaches to knowledge development, including interpretative approaches and contemporary empiricism, as a way to bridge the gap between factual empirical knowledge and the practical application of that knowledge in everyday clinical nursing practice.
Seismic performance of steel pipe pile to cap beam moment resisting connections.
DOT National Transportation Integrated Search
2013-01-01
This research, a joint effort between AUTC and North Carolina State University, is a continuation of an ngoing project that investigated bridge and marine structure : design practices, aiming to identify improved connection design approaches to produ...
Structural steel coatings for corrosion mitigation.
DOT National Transportation Integrated Search
2010-10-01
Task 1 of this project was to survey the performance of coating systems for steel bridges in Missouri and to evaluate coating and : recoating practices. Task 1 was led under the direction of Dr. Glenn Washer from the University of Missouri located in...
Complementarity and Compensation: Bridging the Gap between Writing and Design.
ERIC Educational Resources Information Center
Killingsworth, M. Jimmie; Sanders, Scott P.
1990-01-01
Outlines two rhetorical principles for producing iconic-mosaic texts--the principle of complementarity and the principle of compensation. Shows how these principles can be applied to practical problems in coordinating the writing and design processes in student projects. (RS)
Motion of a liquid bridge between nonparallel surfaces.
Ataei, Mohammadmehdi; Tang, Tian; Amirfazli, Alidad
2017-04-15
Bulk motion of a liquid bridge between two nonparallel identical solid surfaces undergoing multiple loading cycles (compressing and stretching) was investigated numerically and experimentally. The effects of the following governing parameters were studied: the dihedral angle between the two surfaces (ψ), the amount of compressing and stretching (Δh), and wettability parameters i.e. the advancing contact angle (θ a ) and Contact Angle Hysteresis (CAH). Experiments were done using various combinations of ψ, Δh and on surfaces with different wettabilities to understand the effect of each parameter individually. Additionally, a numerical model using Surface Evolver software was developed to augment the experimental data and extract information about the shape of the bridge. An empirical function was proposed and validated to calculate the minimum amount of Δh needed to initiate the bulk motion (i.e. to overcome the initial lag of the motion in response to the compressing of the bridge), at a given dihedral angle ψ. The effect of governing parameters on magnitude and precision of the motion was investigated. The magnitude of the motion was found to be increased by increasing ψ and Δh, and/or by decreasing θ a and CAH. We demonstrated the possibility of modulating the precision of the motion with θ a . Additionally, it was shown that the magnitude of the motion (in one loading cycle) increases after each loading cycle, if the contact lines depin only on the narrower side of the bridge during compressing and only on the wider side during stretching (asymmetric depinning). Whereas, depinning on both sides of the bridge (symmetric depinning) reduced the magnitude of bridge motion in each cycle under cyclic loading. A larger ψ was found to convert symmetric depinning into asymmetric depinning. These findings not only enhance the understanding of bridge motion between nonparallel surfaces, but also are beneficial in controlling magnitude, precision, and lag of the motion in practical applications. Copyright © 2016 Elsevier Inc. All rights reserved.
Nishiye, E; Somlyo, A V; Török, K; Somlyo, A P
1993-01-01
1. The effects of MgADP on cross-bridge kinetics were investigated using laser flash photolysis of caged ATP (P3-1(2-nitrophenyl) ethyladenosine 5'-triphosphate), in guinea-pig portal vein smooth muscle permeabilized with Staphylococcus aureus alpha-toxin. Isometric tension and in-phase stiffness transitions from rigor state were monitored upon photolysis of caged ATP. The estimated concentration of ATP released from caged ATP by high-pressure liquid chromatography (HPLC) was 1.3 mM. 2. The time course of relaxation initiated by photolysis of caged ATP in the absence of Ca2+ was well fitted during the initial 200 ms by two exponential functions with time constants of, respectively, tau 1 = 34 ms and tau 2 = 1.2 s and relative amplitudes of 0.14 and 0.86. Multiple exponential functions were needed to fit longer intervals; the half-time of the overall relaxation was 0.8 s. The second order rate constant for cross-bridge detachment by ATP, estimated from the rate of initial relaxation, was 0.4-2.3 x 10(4) M-1 s-1. 3. MgADP dose dependently reduced both the relative amplitude of the first component and the rate constant of the second component of relaxation. Conversely, treatment of muscles with apyrase, to deplete endogenous ADP, increased the relative amplitude of the first component. In the presence of MgADP, in-phase stiffness decreased during force maintenance, suggesting that the force per cross-bridge increased. The apparent dissociation constant (Kd) of MgADP for the cross-bridge binding site, estimated from its concentration-dependent effect on the relative amplitude of the first component, was 1.3 microM. This affinity is much higher than the previously reported values (50-300 microM for smooth muscle; 18-400 microM for skeletal muscle; 7-10 microM for cardiac muscle). It is possible that the high affinity reflects the properties of a state generated during the co-operative reattachment cycle, rather than that of the rigor bridge. 4. The rate constant of MgADP release from cross-bridges, estimated from its concentration-dependent effect on the rate constant of the second (tau 2) component, was 0.35-7.7 s-1. To the extent that reattachment of cross-bridges could slow relaxation even during the initial 200 ms, this rate constant may be an underestimate. 5. Inorganic phosphate (Pi, 30 mM) did not affect the rate of relaxation during the initial approximately 50 ms, but accelerated the slower phase of relaxation, consistent with a cyclic cross-bridge model in which Pi increases the proportion of cross-bridges in detached ('weakly bound') states.(ABSTRACT TRUNCATED AT 400 WORDS) Images Fig. 1 PMID:8487195
Less than 3 doses of the HPV vaccine – Review of efficacy against virological and disease end points
Basu, Partha; Bhatla, Neerja; Ngoma, Twalib; Sankaranarayanan, Rengaswamy
2016-01-01
ABSTRACT World Health Organization (WHO) recommended 2 doses of the Human Papillomavirus (HPV) vaccine for girls below 15 y on the basis of the immune-bridging studies demonstrating non-inferior immune response of 2 doses in the adolescent girls compared to 3 doses in the young adult women in whom the efficacy against disease is established. The biological nature of the antigens (virus-like particles) constituting the HPV vaccine is responsible for the vigorous antibody response that may make the third dose redundant. The protection offered by 2 doses has been demonstrated in non-randomized clinical trials to be comparable to that offered by 3 doses against incident and persistent infections of vaccine targeted HPV types. However, results emerging from the ecological and nested case-control studies embedded in the population based screening programs of different countries indicate reduced efficacy of 2 doses against virological and disease end points. Some recent studies observed the protective effect of single dose of the vaccine against incident and persistent infections of the vaccine targeted HPV types to be similar to 3 doses in spite of immunological inferiority. The sample size, duration of follow-ups and number of events were limited in these studies. Longer follow ups of the less than 3 doses cohorts in the ongoing studies as well as appropriately designed and ethically justifiable randomized studies are needed to establish the protection offered by the alternative schedules at least beyond 10 y of vaccination. PMID:26933961
Clinical decision-making tools for exam selection, reporting and dose tracking.
Brink, James A
2014-10-01
Although many efforts have been made to reduce the radiation dose associated with individual medical imaging examinations to "as low as reasonably achievable," efforts to ensure such examinations are performed only when medically indicated and appropriate are equally if not more important. Variations in the use of ionizing radiation for medical imaging are concerning, regardless of whether they occur on a local, regional or national basis. Such variations among practices can be reduced with the use of decision support tools at the time of order entry. These tools help reduce radiation exposure among practices through the appropriate use of medical imaging. Similarly, adoption of best practices among imaging facilities can be promoted through tracking the radiation exposure among imaging patients. Practices can benchmark their aggregate radiation exposures for medical imaging through the use of dose index registries. However several variables must be considered when contemplating individual patient dose tracking. The specific dose measures and the variation among them introduced by variations in body habitus must be understood. Moreover the uncertainties in risk estimation from dose metrics related to age, gender and life expectancy must also be taken into account.
The Effect of Measurement Area on Modelling UVR Dose to the Inner Canthus
NASA Astrophysics Data System (ADS)
Birt, Benjamin; Cowling, Ian; Coyne, Steve
People are exposed to varying amounts of UVR throughout their life from both natural and artificial light sources. The dose and rate of UVR exposure required for the formation of non-melanoma skin cancers is inconclusive. Certain regions on the face appear to exhibit a high rate of occurrence of Basal Cell Carcinomas (BCCs) in relation to the perceived dose of UVR. One of these regions is the inner canthus located on the medial side of the eye. The inner canthus appears to be well protected from large direct doses of ultraviolet radiation (UVR). Facial features such as eyelids, eye brow ridge, nasal bridge and cheek, combine to limit the solid angle of the field of view of the inner canthus to UVR from overhead sources. To explain the unexpected high rate of BCCs it is hypothesized that a percentage of the radiation incident on the eye is reflected onto the inner canthus. This paper showed that a portion of the radiation incident onto the eye was reflected towards the inner canthus. The percentage increase above the direct dose was only 2% across the whole region. As the detector elements decrease in size it is observed on a cellular level that some of the cells dose increased by 30% when the reflections were considered.
Gottlieb, Assaf; Daneshjou, Roxana; DeGorter, Marianne; Bourgeois, Stephane; Svensson, Peter J; Wadelius, Mia; Deloukas, Panos; Montgomery, Stephen B; Altman, Russ B
2017-11-24
Genome-wide association studies are useful for discovering genotype-phenotype associations but are limited because they require large cohorts to identify a signal, which can be population-specific. Mapping genetic variation to genes improves power and allows the effects of both protein-coding variation as well as variation in expression to be combined into "gene level" effects. Previous work has shown that warfarin dose can be predicted using information from genetic variation that affects protein-coding regions. Here, we introduce a method that improves dose prediction by integrating tissue-specific gene expression. In particular, we use drug pathways and expression quantitative trait loci knowledge to impute gene expression-on the assumption that differential expression of key pathway genes may impact dose requirement. We focus on 116 genes from the pharmacokinetic and pharmacodynamic pathways of warfarin within training and validation sets comprising both European and African-descent individuals. We build gene-tissue signatures associated with warfarin dose in a cohort-specific manner and identify a signature of 11 gene-tissue pairs that significantly augments the International Warfarin Pharmacogenetics Consortium dosage-prediction algorithm in both populations. Our results demonstrate that imputed expression can improve dose prediction and bridge population-specific compositions. MATLAB code is available at https://github.com/assafgo/warfarin-cohort.
Kreimer, Aimée R; Herrero, Rolando; Sampson, Joshua N; Porras, Carolina; Lowy, Douglas R; Schiller, John T; Schiffman, Mark; Rodriguez, Ana Cecilia; Chanock, Stephen; Jimenez, Silvia; Schussler, John; Gail, Mitchell H; Safaeian, Mahboobeh; Kemp, Troy J; Cortes, Bernal; Pinto, Ligia A; Hildesheim, Allan; Gonzalez, Paula
2018-01-20
The Costa Rica Vaccine Trial (CVT), a phase III randomized clinical trial, provided the initial data that one dose of the HPV vaccine could provide durable protection against HPV infection. Although the study design was to administer all participants three doses of HPV or control vaccine, 20% of women did not receive the three-dose regimens, mostly due to involuntary reasons unrelated to vaccination. In 2011, we reported that a single dose of the bivalent HPV vaccine could be as efficacious as three doses of the vaccine using the endpoint of persistent HPV infection accumulated over the first four years of the trial; findings independently confirmed in the GSK-sponsored PATRICIA trial. Antibody levels after one dose, although lower than levels elicited by three doses, were 9-times higher than levels elicited by natural infection. Importantly, levels remained essentially constant over at least seven years, suggesting that the observed protection provided by a single dose might be durable. Much work has been done to assure these non-randomized findings are valid. Yet, the group of recipients who received one dose of the bivalent HPV vaccine in the CVT and PATRICIA trials was small and not randomly selected nor blinded to the number of doses received. The next phase of research is to conduct a formal randomized, controlled trial to evaluate the protection afforded by a single dose of HPV vaccine. Complementary studies are in progress to bridge our findings to other populations, and to further document the long-term durability of antibody response following a single dose. Published by Elsevier Ltd.
Bridging the gap: a review of dose investigations in paediatric investigation plans.
Hampson, Lisa V; Herold, Ralf; Posch, Martin; Saperia, Julia; Whitehead, Anne
2014-10-01
In the EU, development of new medicines for children should follow a prospectively agreed paediatric investigation plan (PIP). Finding the right dose for children is crucial but challenging due to the variability of pharmacokinetics across age groups and the limited sample sizes available. We examined strategies adopted in PIPs to support paediatric dosing recommendations to identify common assumptions underlying dose investigations and the attempts planned to verify them in children. We extracted data from 73 PIP opinions recently adopted by the Paediatric Committee of the European Medicines Agency. These opinions represented 79 medicinal development programmes and comprised a total of 97 dose investigation studies. We identified the design of these dose investigation studies, recorded the analyses planned and determined the criteria used to define target doses. Most dose investigation studies are clinical trials (83 of 97) that evaluate a single dosing rule. Sample sizes used to investigate dose are highly variable across programmes, with smaller numbers used in younger children (< 2 years). Many studies (40 of 97) do not pre-specify a target dose criterion. Of those that do, most (33 of 57 studies) guide decisions using pharmacokinetic data alone. Common assumptions underlying dose investigation strategies include dose proportionality and similar exposure-response relationships in adults and children. Few development programmes pre-specify steps to verify assumptions in children. There is scope for the use of Bayesian methods as a framework for synthesizing existing information to quantify prior uncertainty about assumptions. This process can inform the design of optimal drug development strategies. © 2014 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.
MO-E-18A-01: Imaging: Best Practices In Pediatric Imaging
DOE Office of Scientific and Technical Information (OSTI.GOV)
Willis, C; Strauss, K; MacDougall, R
This imaging educational program will focus on solutions to common pediatric imaging challenges. The speakers will present collective knowledge on best practices in pediatric imaging from their experience at dedicated children's hospitals. Areas of focus will include general radiography, the use of manual and automatic dose management in computed tomography, and enterprise-wide radiation dose management in the pediatric practice. The educational program will begin with a discussion of the complexities of exposure factor control in pediatric projection radiography. Following this introduction will be two lectures addressing the challenges of computed tomography (CT) protocol optimization in the pediatric population. The firstmore » will address manual CT protocol design in order to establish a managed radiation dose for any pediatric exam on any CT scanner. The second CT lecture will focus on the intricacies of automatic dose modulation in pediatric imaging with an emphasis on getting reliable results in algorithmbased technique selection. The fourth and final lecture will address the key elements needed to developing a comprehensive radiation dose management program for the pediatric environment with particular attention paid to new regulations and obligations of practicing medical physicists. Learning Objectives: To understand how general radiographic techniques can be optimized using exposure indices in order to improve pediatric radiography. To learn how to establish diagnostic dose reference levels for pediatric patients as a function of the type of examination, patient size, and individual design characteristics of the CT scanner. To learn how to predict the patient's radiation dose prior to the exam and manually adjust technique factors if necessary to match the patient's dose to the department's established dose reference levels. To learn how to utilize manufacturer-provided automatic dose modulation technology to consistently achieve patient doses within the department's established size-based diagnostic reference range. To understand the key components of an enterprise-wide pediatric dose management program that integrates the expanding responsibilities of medial physicists in the new era of dose monitoring.« less
Synthesis and characterization of γ-irradiated cadmium-borate glasses doped V2O5
NASA Astrophysics Data System (ADS)
Bahammam, S.; Abd El Al, S.; Ezz-Eldin, F. M.
In this work, we study the relationship between the optical and magnetic properties for the irradiated and unirradiated V2O5-doped cadmium borate glasses and examined their optical band energy that has compromise of non-bridging oxygen (NBO) and bridging oxygen (BO), V3+, V4+ and V5+, and BO3 units and BO4 units. The induced defects created by γ-rays were characterized by optical and EPR spectroscopy. The dependability of the defects and the tendency for recombination or conversion of the defects besides the environment of optically dynamic V centers was also discussed. It is concluded that the development of both optical and magnetic intensity is related to V4+ ions at tetrahedral sites whereas the decrease in their intensity is recognized to the ligand-metal charge transfer transitions of V4+ ions coupled to V5+. The optical band gap energy (Eg) has been observed to decrease with increasing either V2O5 content or γ-doses. High γ-dose reduces the values of the allowed direct optical band gap Eg of 0.5 Mol% V2O5 glass up to 45 kGy after which Eg increases, but remain lower than that of un-irradiated glass. Borate glasses under this study showed linear optical absorption response over the dose range of 5-80 kG. Fading under dark and room light in 2 h after exposure in the course of 30 days have been studied in detail and presented. Our results and findings indicate that, the investigated samples may be seemed to be a good candidate for radiation processing purposes.
Mamidi, Ranganath; Li, Jiayang; Gresham, Kenneth S; Verma, Sujeet; Doh, Chang Yoon; Li, Amy; Lal, Sean; Dos Remedios, Cristobal G; Stelzer, Julian E
2017-10-01
Omecamtiv mecarbil (OM) enhances systolic function in vivo by directly binding the myosin cross-bridges (XBs) in the sarcomere. However, the mechanistic details governing OM-induced modulation of XB behavior in failing human myocardium are unclear. The effects of OM on steady state and dynamic XB behavior were measured in chemically skinned myocardial preparations isolated from human donor and heart failure (HF) left ventricle. HF myocardium exhibited impaired contractile function as evidenced by reduced maximal force, magnitude of XB recruitment ( P df ), and a slowed rate of XB detachment ( k rel ) at submaximal Ca 2+ activations. Ca 2+ sensitivity of force generation (pCa 50 ) was higher in HF myocardium when compared with donor myocardium, both prior to and after OM incubations. OM incubation (0.5 and 1.0 μmol/L) enhanced force generation at submaximal Ca 2+ activations in a dose-dependent manner. Notably, OM induced a slowing in k rel with 1.0 μmol/L OM but not with 0.5 μmol/L OM in HF myocardium. Additionally, OM exerted other differential effects on XB behavior in HF myocardium as evidenced by a greater enhancement in P df and slowing in the time course of cooperative XB recruitment ( T rec ), which collectively prolonged achievement of peak force development ( T pk ), compared with donor myocardium. Our findings demonstrate that OM augments force generation but also prolongs the time course of XB transitions to force-bearing states in remodeled HF myocardium, which may extend the systolic ejection time in vivo. Optimal OM dosing is critical for eliciting enhanced systolic function without excessive prolongation of systolic ejection time, which may compromise diastolic filling. © 2017 American Heart Association, Inc.
Sudan, Ajay; Livermore, Joanne; Howard, Susan J.; Al-Nakeeb, Zaid; Sharp, Andrew; Goodwin, Joanne; Gregson, Lea; Warn, Peter A.; Felton, Tim W.; Perfect, John R.; Harrison, Thomas S.
2013-01-01
Fluconazole is frequently the only antifungal agent that is available for induction therapy for cryptococcal meningitis. There is relatively little understanding of the pharmacokinetics and pharmacodynamics (PK-PD) of fluconazole in this setting. PK-PD relationships were estimated with 4 clinical isolates of Cryptococcus neoformans. MICs were determined using Clinical and Laboratory Standards Institute (CLSI) methodology. A nonimmunosuppressed murine model of cryptococcal meningitis was used. Mice received two different doses of fluconazole (125 mg/kg of body weight/day and 250 mg/kg of body weight/day) orally for 9 days; a control group of mice was not given fluconazole. Fluconazole concentrations in plasma and in the cerebrum were determined using high-performance liquid chromatography (HPLC). The cryptococcal density in the brain was estimated using quantitative cultures. A mathematical model was fitted to the PK-PD data. The experimental results were extrapolated to humans (bridging study). The PK were linear. A dose-dependent decline in fungal burden was observed, with near-maximal activity evident with dosages of 250 mg/kg/day. The MIC was important for understanding the exposure-response relationships. The mean AUC/MIC ratio associated with stasis was 389. The results of the bridging study suggested that only 66.7% of patients receiving 1,200 mg/kg would achieve or exceed an AUC/MIC ratio of 389. The potential breakpoints for fluconazole against Cryptococcus neoformans follow: susceptible, ≤2 mg/liter; resistant, >2 mg/liter. Fluconazole may be an inferior agent for induction therapy because many patients cannot achieve the pharmacodynamic target. Clinical breakpoints are likely to be significantly lower than epidemiological cutoff values. The MIC may guide the appropriate use of fluconazole. If fluconazole is the only option for induction therapy, then the highest possible dose should be used. PMID:23571544
Evaluation of Rocky Point Viaduct Concrete Beam : Final Report
DOT National Transportation Integrated Search
2000-06-01
This study was intended to determine why it was necessary to replace the Rocky Point Viaduct after a period of service that was much shorter than that of many other reinforced concrete bridges on the Oregon coast; to identify construction practices t...
Evaluation of Rocky Point Viaduct concrete beam : appendices
DOT National Transportation Integrated Search
2000-06-01
This study was intended to determine why it was necessary to replace the Rocky Point Viaduct after a period of service that was much shorter than that of many other reinforced concrete bridges on the Oregon coast; to identify construction practices t...
ERIC Educational Resources Information Center
Pai, Devdas M.; DeBlasio, Richard A.
1997-01-01
The example of Alcoa and North Carolina State University shows that partnerships in course design, development, and delivery can result in an engineering curriculum that bridges theory and practice and makes students aware of industry expectations. (SK)
Practical methods for analyzing pedestrian and bicycle use of a transportation facility.
DOT National Transportation Integrated Search
2010-02-01
The objective of the project is to analyze existing technologies used for the process of generating counts of bicycles : and pedestrians in transportation facilities such as walk and bicycle bridges, urban bicycle routes, bicycle trails etc. : The ad...
ERIC Educational Resources Information Center
Journal of Experiential Education, 1981
1981-01-01
A new journal feature shares practical ideas in experiential education in less than 800 words. This issue presents an initiative problem, rules for rope push, exercise illustrating dependence on schedules, how to experience a handicap, maple sugaring project, assignment bridging the generation gap, simulating literary experiences, and local…
Jenkins, Sandra K; Thomas, Mary Beth
2005-01-01
Both theoretical thinking and practical wisdom are used by health professionals in their clinical practice. Lately, discussion has centered on the abstract phrase "theory-practice gap." The health profession is not the only discipline that seeks unity in theory and practice issues. Education is also building bridges in this arena. One reoccurring myth is the notion that theory and practice are separate; as a result, this gives a mistaken impression that theory serves no purpose in practice. Discussion of the issues in this paper includes definitions of theoretical thinking and practical wisdom, theoretical and practical knowledge development, and relevance to health professional's education, practice and science. These issues must be communicated to practitioners, educators and theorists. A collective definition to begin communication is proposed and suggestions are offered for addressing key issues.
The microcomputer in the dental office: a new diagnostic aid.
van der Stelt, P F
1985-06-01
The first computer applications in the dental office were based upon standard accountancy procedures. Recently, more and more computer applications have become available to meet the specific requirements of dental practice. This implies not only business procedures, but also facilities to store patient records in the system and retrieve them easily. Another development concerns the automatic calculation of diagnostic data such as those provided in cephalometric analysis. Furthermore, growth and surgical results in the craniofacial area can be predicted by computerized extrapolation. Computers have been useful in obtaining the patient's anamnestic data objectively and for the making of decisions based on such data. Computer-aided instruction systems have been developed for undergraduate students to bridge the gap between textbook and patient interaction without the risks inherent in the latter. Radiology will undergo substantial changes as a result of the application of electronic imaging devices instead of the conventional radiographic films. Computer-assisted electronic imaging will enable image processing, image enhancement, pattern recognition and data transmission for consultation and storage purposes. Image processing techniques will increase image quality whilst still allowing low-dose systems. Standardization of software and system configuration and the development of 'user friendly' programs is the major concern for the near future.
Susan Cordell
2012-01-01
In his new book, Bob Cabin uses his personal involvement in the restoration of Hawai'i dry forests to illustrate the tensions that he feels exists between the science and practice of ecological restoration. It is a journey that starts out among the multidisciplinary, multi-interest perspectives associated with a grass-roots communitybased working group (Part 1,...
ERIC Educational Resources Information Center
Johnson, William H.E.
A study conducted in Poland, Yugoslavia, Czechoslovakia, and the U.S.S.R. reports how these countries functioned in bridging the traditional gap between the development of theoretical research in education and the achievement of the desired reforms in school policies and practices. The choice of communist dictatorships as study subjects was based…
Patient Dose Management: Focus on Practical Actions
2016-01-01
Medical radiation is a very important part of modern medicine, and should be only used when needed and optimized. Justification and optimization of radiation examinations must be performed. The first step of reduction of medical exposure is to know the radiation dose in currently performed examinations. This review covers radiation units, how various imaging modalities report dose, and the current status of radiation dose reports and legislation. Also, practical tips that can be applied to clinical practice are introduced. Afterwards, the importance of radiology exposure related education is emphasized and the current status of education for medical personal and the public is explained, and appropriate education strategies are suggested. Commonly asked radiation dose related example questions and answers are provided in detail to allow medical personnel to answer patients. Lastly, we talk about computerized programs that can be used in medical facilities for managing patient dose. While patient dose monitoring and management should be used to decrease and optimize overall radiation dose, it should not be used to assess individual cancer risk. One must always remember that medically justified examinations should always be performed, and unneeded examinations should be avoided in the first place. PMID:26908988
Einstein, Andrew J; Pascual, Thomas N B; Mercuri, Mathew; Karthikeyan, Ganesan; Vitola, João V; Mahmarian, John J; Better, Nathan; Bouyoucef, Salah E; Hee-Seung Bom, Henry; Lele, Vikram; Magboo, V Peter C; Alexánderson, Erick; Allam, Adel H; Al-Mallah, Mouaz H; Flotats, Albert; Jerome, Scott; Kaufmann, Philipp A; Luxenburg, Osnat; Shaw, Leslee J; Underwood, S Richard; Rehani, Madan M; Kashyap, Ravi; Paez, Diana; Dondi, Maurizio
2015-07-07
To characterize patient radiation doses from nuclear myocardial perfusion imaging (MPI) and the use of radiation-optimizing 'best practices' worldwide, and to evaluate the relationship between laboratory use of best practices and patient radiation dose. We conducted an observational cross-sectional study of protocols used for all 7911 MPI studies performed in 308 nuclear cardiology laboratories in 65 countries for a single week in March-April 2013. Eight 'best practices' relating to radiation exposure were identified a priori by an expert committee, and a radiation-related quality index (QI) devised indicating the number of best practices used by a laboratory. Patient radiation effective dose (ED) ranged between 0.8 and 35.6 mSv (median 10.0 mSv). Average laboratory ED ranged from 2.2 to 24.4 mSv (median 10.4 mSv); only 91 (30%) laboratories achieved the median ED ≤ 9 mSv recommended by guidelines. Laboratory QIs ranged from 2 to 8 (median 5). Both ED and QI differed significantly between laboratories, countries, and world regions. The lowest median ED (8.0 mSv), in Europe, coincided with high best-practice adherence (mean laboratory QI 6.2). The highest doses (median 12.1 mSv) and low QI (4.9) occurred in Latin America. In hierarchical regression modelling, patients undergoing MPI at laboratories following more 'best practices' had lower EDs. Marked worldwide variation exists in radiation safety practices pertaining to MPI, with targeted EDs currently achieved in a minority of laboratories. The significant relationship between best-practice implementation and lower doses indicates numerous opportunities to reduce radiation exposure from MPI globally. © The Author 2015. Published by Oxford University Press on behalf of the European Society of Cardiology.
Wood, T J; Moore, C S; Stephens, A; Saunderson, J R; Beavis, A W
2015-09-01
Given the increasing use of computed tomography (CT) in the UK over the last 30 years, it is essential to ensure that all imaging protocols are optimised to keep radiation doses as low as reasonably practicable, consistent with the intended clinical task. However, the complexity of modern CT equipment can make this task difficult to achieve in practice. Recent results of local patient dose audits have shown discrepancies between two Philips CT scanners that use the DoseRight 2.0 automatic exposure control (AEC) system in the 'automatic' mode of operation. The use of this system can result in drifting dose and image quality performance over time as it is designed to evolve based on operator technique. The purpose of this study was to develop a practical technique for configuring examination protocols on four CT scanners that use the DoseRight 2.0 AEC system in the 'manual' mode of operation. This method used a uniform phantom to generate reference images which form the basis for how the AEC system calculates exposure factors for any given patient. The results of this study have demonstrated excellent agreement in the configuration of the CT scanners in terms of average patient dose and image quality when using this technique. This work highlights the importance of CT protocol harmonisation in a modern Radiology department to ensure both consistent image quality and radiation dose. Following this study, the average radiation dose for a range of CT examinations has been reduced without any negative impact on clinical image quality.
Myocarditis in athlete and myocardial bridge: An innocent bystander?
Quaranta, Federico; Guerra, Emanuele; Sperandii, Fabio; De Santis, Francesco; Pigozzi, Fabio; Calò, Leonardo; Borrione, Paolo
2015-01-01
Myocarditis is a bacterial or viral inflammatory disease, often unnoticed or misdiagnosed. Athletes with myocarditis must stop practicing their activity since International medical Literature described some cases of sudden death. In the present report, we describe a case of an asymptomatic, apparently healthy, competitive athletes, who was diagnosed a myocarditis and as incidental finding a myocardial bridging. We focused the attention on the importance of anamnesis, electrocardiogram and athletes’ entourage for the diagnosis of such insidious pathologies and we evaluated the follow up, focusing the attention on electrocardiogram changes as well as on restitution ad integrum and prognosis, especially for the athletes. PMID:26015860
The medical practice as business organization.
Bender, A D; Aaronson, W E; Krasnick, C J; Bender, J G
1996-03-01
Medical practices historically have not been examined in terms of their organizational structures and of the appropriateness of their structures for survival as business entities. In this paper, we propose a model for the typical medical practice and discuss its fit with current organizational theory. It is apparent that the medical practice organization does not fit with the demands of a rapidly changing and complex environment. To survive and grow, the medical practice organization must align itself with others that have an interest and stake in the health care system, develop teamwork among physicians, bridge the gap between physicians and others in the organization, and recognize that the work done in the organization depends on other components of the organization.
Østergaard, Søren D; Opler, Mark G A; Correll, Christoph U
2017-12-01
There is currently a "measurement gap" between research and clinical care in schizophrenia. The main reason behind this gap is that the most widely used rating scale in schizophrenia research, the 30-item Positive and Negative Syndrome Scale (PANSS), takes so long to administer that it is rarely used in clinical practice. This compromises the translation of research findings into clinical care and vice versa. The aim of this paper is to discuss how this measurement gap can be closed. Specifically, the main points of discussion are 1) the practical problems associated with using the full 30-item PANSS in clinical practice; 2) how the brief, six-item version of the Positive and Negative Syndrome Scale (PANSS-6) was derived empirically from the full 30-item PANSS and what the initial results obtained with PANSS-6 entail; and 3) how PANSS-6 ratings, guided by the newly developed, 15-25-minute, stand-alone Simplified Negative and Positive Symptoms Interview (SNAPSI), might help bridge the measurement gap between research and clinical care in schizophrenia. The full 30-item PANSS is often used in research studies, but is too time consuming to allow for routine clinical use. Recent studies suggest that the much briefer PANSS-6 is a psychometrically valid measure of core positive and negative symptoms of schizophrenia and that the scale is sensitive to symptom improvement following pharmacological treatment. SNAPSI is a brief interview that yields the information needed to rate PANSS-6 (and other brief rating scales). We believe that PANSS-6 ratings guided by SNAPSI will help bridge the measurement gap between research and clinical care in schizophrenia.
Goodman, Shaun G; Langer, Anatoly; Bastien, Natacha R; McPherson, Ruth; Francis, Gordon A; Genest, Jacques J; Leiter, Lawrence A
2010-11-01
Despite clear guideline recommendations, there is a growing body of evidence that there is suboptimal use of lipid-lowering treatment in Canadians. To assess the prevalence and types of persistent lipid abnormalities in Canadian patients receiving statin therapy. The present cross-sectional study recruited 2436 outpatients 45 years of age or older who were treated with statins by 232 physicians from 10 provinces; all underwent clinical examination and had their latest fasting lipid values while on statin therapy recorded. The median patient age was 66 years (interquartile range [IQR] 58 to 74 years), 60% were men and 80% were in the high 10-year risk category. The median low-density lipoprotein cholesterol level was 2.0 mmol/L (IQR 1.6 mmol/L to 2.5 mmol/L) and the median total cholesterol/high-density lipoprotein cholesterol ratio was 3.4 mmol/L (IQR 2.8 mmol/L to 4.1 mmol/L). However, based on the 2006 Canadian Cardiovascular Society recommendations, 37% of all patients did not have a low-density lipoprotein cholesterol level at goal or intervention target level, including 45% of high-risk category patients. The majority of patients received atorvastatin (50%) or rosuvastatin (37%) but primarily at low-to-medium doses, and a minority (14%) received additional lipid-modifying therapies. The present observational study highlights the need for more intensive treatment of lipid abnormalities, particularly among high-risk patients. Recognizing several important limitations related to the observational nature of the study, the findings suggest the possibility that, in addition to optimizing adherence, there remains an important need to titrate current statin therapy to higher doses and potentially use a combination of lipid-modifying treatments (once the statin dose has been truly maximized) to further bridge the gap between evidence-based medicine and current Canadian practice.
Calladine, C. R.
2015-01-01
Davies Gilbert's work on the catenary is notable on two counts. First, it influenced Thomas Telford in formulating his final design for the Menai Strait suspension bridge (1826); and second, it established for the first time the form of the ‘catenary of equal strength’. The classical catenary is a uniform flexible chain or cable hanging freely under gravity between supports. The ‘catenary of equal strength’ is the form of a cable whose cross-sectional area is made proportional to the tension at each point, so that the tensile stress is uniform throughout. In this paper I provide a sketch of the lives and achievements of Gilbert and Telford, and of their interaction over the Menai Bridge. There follows a commentary on Gilbert's 1826 paper, and on his two related publications; and a brief sketch of the earlier history of the catenary. I then describe the development of the suspension bridge up to the present time. Finally, I discuss relations between mathematical analysts and practical engineers. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society. PMID:25750153
Behaviour of several fatigue prone bridge details
NASA Astrophysics Data System (ADS)
Kubiš, Petr; Ryjáček, Pavel
2017-09-01
Three fatigue welded bridge joints analysed in this work are the alternative details of the bottom flange connection. This construction detail is mainly used for the erection connection for steel and composite bridges. If applied in the place, where live load is significant, the fatigue becomes the main design criterion. The detail category is thus very important factor. The aim of this paper is to analyse the possibilities of the improving the behaviour of this detail, by various methods. First solution is to modify the shape of the cope hole to the elliptic shape. Second option is to use the “Olemutz” fully welded detail. This detail is often used in bridge designing despite there is no exact information about the fatigue category, and doubts of the performance exists. “Olemutz” is a long web plate slit that is filled by the double bevel weld after the execution of the bottom flange weld. The last detail is the elliptic cope hole filled by the plate-cap welded into an empty hole. The geometry is the same, as in the first case. The conclusion of the numerical analysis and the pilot fatigue experiments is discussed with several practical recommendations for designing.
The influence of carbonation process on concrete bridges and durability in Estonian practice
NASA Astrophysics Data System (ADS)
Liisma, E.; Sein, S.; Järvpõld, M.
2017-10-01
Concrete as one of the most widely used construction material in building industry, has considerable implementing in bridge engineering due to its extensive number of effective technical characteristics. However, according to exploitation environment, there are substantial factors such as aggressive liquids (e.g. deiced salts, sulfates, etc), rapid temperature alterations and the increasing rate of CO2 to take into account predicting actual retained service life of concrete structure and the need of repairmen to increase the lifespan of the bridge. According to several measuring, concentration of atmospheric CO2 is reported linearly increasing and is modeled to appear as exponential increase in the next decade. This environmental influence leads to accelerated carbonation process of concrete and brings up the importance of its potential untimely degradation mechanism. Hence, the main aim of this research is to give an analyzed overview of the carbonation depths of selection of 11 concrete bridges in Estonia built in the period of 1976-2007 and their relation with compressive strength of concrete. In addition to in situ tests, laboratory research was performed to understand natural carbonation rate and compressive strength relations of concrete.
42 CFR 82.3 - What Are the Requirements for Dose Reconstruction Under EEOICPA?
Code of Federal Regulations, 2010 CFR
2010-10-01
... SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES METHODS FOR CONDUCTING DOSE... unrecorded doses, which are estimated using commonly practiced dose reconstruction methods and would have to...
DOE Office of Scientific and Technical Information (OSTI.GOV)
Unkelbach, Jan, E-mail: junkelbach@mgh.harvard.edu; Botas, Pablo; Faculty of Physics, Ruprecht-Karls-Universität Heidelberg, Heidelberg
Purpose: We describe a treatment plan optimization method for intensity modulated proton therapy (IMPT) that avoids high values of linear energy transfer (LET) in critical structures located within or near the target volume while limiting degradation of the best possible physical dose distribution. Methods and Materials: To allow fast optimization based on dose and LET, a GPU-based Monte Carlo code was extended to provide dose-averaged LET in addition to dose for all pencil beams. After optimizing an initial IMPT plan based on physical dose, a prioritized optimization scheme is used to modify the LET distribution while constraining the physical dosemore » objectives to values close to the initial plan. The LET optimization step is performed based on objective functions evaluated for the product of LET and physical dose (LET×D). To first approximation, LET×D represents a measure of the additional biological dose that is caused by high LET. Results: The method is effective for treatments where serial critical structures with maximum dose constraints are located within or near the target. We report on 5 patients with intracranial tumors (high-grade meningiomas, base-of-skull chordomas, ependymomas) in whom the target volume overlaps with the brainstem and optic structures. In all cases, high LET×D in critical structures could be avoided while minimally compromising physical dose planning objectives. Conclusion: LET-based reoptimization of IMPT plans represents a pragmatic approach to bridge the gap between purely physical dose-based and relative biological effectiveness (RBE)-based planning. The method makes IMPT treatments safer by mitigating a potentially increased risk of side effects resulting from elevated RBE of proton beams near the end of range.« less
Linnemann, Désirée Larenas; Gupta, Payel; Mithani, Sima; Ponda, Punita
2012-01-01
Background Several practical issues dealing with the exact application of allergen immunotherapy (AIT) among European and US allergists are not well known. Guidelines on AIT give recommendations and suggestions for only some of them. We present this unique survey with worldwide response. Methods The AAAAI immunotherapy committee conducted a web-based practice patterns survey (program: Survey Monkey) among all members in&outside US on dosing, dose-adjustment after missed doses and duration of AIT. Results 1201 Returned questionnaires (almost 25% response rate). 21% were non-US-Canada members. Maintenance doses in USCan are (mean/median): Dermatophagoides farinae (Df) combined with Dermatophagoides pteronyssinus (Dpt): 2155/1000AU; Df solo 2484/1000AU. Dpt when combined with Df 1937/1000AU; Dpt solo: 2183/1000AU.Cat 3224/2000BAU. Grass 11,410/4000BAU. 57-65% of the dosing falls within the recommended Practice Parameters recommended ranges. Non-USCan allergists expressed maintenance doses in many different units making analysis impossible. Dose-adjustment after missed doses is based on ‘time elapsed since the last applied dose’ by 77% of USCan and 58% of non-USCan allergists and on ‘time since missed scheduled dose’ by the rest. Doses are adjusted when a patient comes in more than 14 d/5 wk after the last administration at build-up/maintenance by both USCan and non-USCan colleagues. The mostly followed dose-adjustment schedules after 1, 2, 3 missed doses are: Build-up: repeat last dose, reduce by one dose, reduce by 2 doses; maintenance: reduce by one dose, reduce by 2 doses, reduce by 3 doses. 26% uses a different approach reducing doses by a certain percentage or volume. AIT is restarted after a gap in build-up of >30 days and of >12 weeks during maintenance in both groups (median). Outside USCan AIT is prescribed for 3 years (Median). However, 75% of USCan allergists prescribes AIT for 5 years. Main reasons why to continue AIT beyond 5 years: ‘symptoms came back after stopping’ or “patient afraid to relapse.” Conclusions These results show regional differences on some points (especially AIT duration) and they suggest in which direction to plan further research in 2 areas to establish universal dose-adjustment plans for missed applications and define the usefulness (or lack of) of long-term AIT. Moreover, there is still room for improvement in the way AIT is dosed.
Evidence-based Practice for Mere Mortals
Sim, Ida; Sanders, Gillian D; McDonald, Kathryn M
2002-01-01
The poor translation of evidence into practice is a well-known problem. Hopes are high that information technology can help make evidence-based practice feasible for mere mortal physicians. In this paper, we draw upon the methods and perspectives of clinical practice, medical informatics, and health services research to analyze the gap between evidence and action, and to argue that computing systems for bridging this gap should incorporate both informatics and health services research expertise. We discuss 2 illustrative systems—trial banks and a web-based system to develop and disseminate evidence-based guidelines (alchemist)— and conclude with a research and training agenda. PMID:11972727
Evidence-based practice for mere mortals: the role of informatics and health services research.
Sim, Ida; Sanders, Gillian D; McDonald, Kathryn M
2002-04-01
The poor translation of evidence into practice is a well-known problem. Hopes are high that information technology can help make evidence-based practice feasible for mere mortal physicians. In this paper, we draw upon the methods and perspectives of clinical practice, medical informatics, and health services research to analyze the gap between evidence and action, and to argue that computing systems for bridging this gap should incorporate both informatics and health services research expertise. We discuss 2 illustrative systems--trial banks and a web-based system to develop and disseminate evidence-based guidelines (alchemist)--and conclude with a research and training agenda.
[Reflection of estimating postmortem interval in forensic entomology and the Daubert standard].
Xie, Dan; Peng, Yu-Long; Guo, Ya-Dong; Cai, Ji-Feng
2013-08-01
Estimating postmortem interval (PMI) is always the emphasis and difficulty in forensic practice. Forensic entomology plays a significant indispensable role. Recently, the theories and technologies of forensic entomology are increasingly rich. But many problems remain in the research and practice. With proposing the Daubert standard, the reliability and accuracy of estimation PMI by forensic entomology need more demands. This review summarizes the application of the Daubert standard in several aspects of ecology, quantitative genetics, population genetics, molecular biology, and microbiology in the practice of forensic entomology. It builds a bridge for basic research and forensic practice to provide higher accuracy for estimating postmortem interval by forensic entomology.
NASA Astrophysics Data System (ADS)
Zheng, Y.; Ganushkina, N. Y.; Guild, T. B.; Jiggens, P.; Jun, I.; Mazur, J. E.; Meier, M. M.; Minow, J. I.; Pitchford, D. A.; O'Brien, T. P., III; Shprits, Y.; Tobiska, W. K.; Xapsos, M.; Rastaetter, L.; Jordanova, V. K.; Kellerman, A. C.; Fok, M. C. H.
2017-12-01
The Community Coordinated Modeling Center (CCMC) has been leading the community-wide model validation projects for many years. Such effort has been broadened and extended via the newly-launched International Forum for Space Weather Modeling Capabilities Assessment (https://ccmc.gsfc.nasa.gov/assessment/), Its objective is to track space weather models' progress and performance over time, which is critically needed in space weather operations. The Radiation and Plasma Effects Working Team is working on one of the many focused evaluation topics and deals with five different subtopics: Surface Charging from 10s eV to 40 keV electrons, Internal Charging due to energetic electrons from hundreds keV to several MeVs. Single Event Effects from solar energetic particles (SEPs) and galactic cosmic rays (GCRs) (several MeV to TeVs), Total Dose due to accumulation of doses from electrons (>100 KeV) and protons (> 1 MeV) in a broad energy range, and Radiation Effects from SEPs and GCRs at aviation altitudes. A unique aspect of the Radiation and Plasma Effects focus area is that it bridges the space environments, engineering and user community. This presentation will summarize the working team's progress in metrics discussion/definition and the CCMC web interface/tools to facilitate the validation efforts. As an example, tools in the areas of surface charging/internal charging will be demoed.
Characterization of stormwater runoff from bridge decks in eastern Massachusetts, 2014–16
Smith, Kirk P.; Sorenson, Jason R.; Granato, Gregory E.
2018-05-02
The quality of stormwater runoff from bridge decks (hereafter referred to as “bridge-deck runoff”) was characterized in a field study from August 2014 through August 2016 in which concentrations of suspended sediment (SS) and total nutrients were monitored. These new data were collected to supplement existing highway-runoff data collected in Massachusetts which were deficient in bridge-deck runoff concentration data. Monitoring stations were installed at three bridges maintained by the Massachusetts Department of Transportation in eastern Massachusetts (State Route 2A in the city of Boston, Interstate 90 in the town of Weston, and State Route 20 near Quinsigamond Village in the city of Worcester). The bridges had annual average daily traffic volumes from 21,200 to 124,000 vehicles per day; the land use surrounding the monitoring stations was 25 to 67 percent impervious.Automatic-monitoring techniques were used to collect more than 160 flow-proportional composite samples of bridge-deck runoff. Samples were analyzed for concentrations of SS, loss on ignition of suspended solids (LOI), particulate carbon (PC), total phosphorus (TP), total dissolved nitrogen (DN), and particulate nitrogen (PN). The distribution of particle size of SS also was determined for composite samples. Samples of bridge-deck runoff were collected year round during rain, mixed precipitation, and snowmelt runoff and with different dry antecedent periods throughout the 2-year sampling period.At the three bridge-deck-monitoring stations, median concentrations of SS in composite samples of bridge-deck runoff ranged from 1,490 to 2,020 milligrams per liter (mg/L); however, the range of SS in individual composites was vast at 44 to 142,000 mg/L. Median concentrations of SS were similar in composite samples collected from the State Route 2A and Interstate 90 bridge (2,010 and 2,020 mg/L, respectively), and lowest at the State Route 20 bridge (1,490 mg/L). Concentrations of coarse sediment (greater than 0.25 millimeters in diameter) dominated the SS matrix by more than an order of magnitude. Concentrations of LOI and PC in composite samples ranged from 15 to 1,740 mg/L and 6.68 to 1,360 mg/L, respectively, and generally represented less than 10 and 3 percent of the median mass of SS, respectively. Concentrations of TP in composite samples ranged from 0.09 to 7.02 mg/L; median concentrations of TP ranged from 0.505 to 0.69 mg/L and were highest on the bridge on State Route 2A in Boston. Concentrations of total nitrogen (TN) (sum DN and PN) in composite samples were variable (0.36 to 29 mg/L). Median DN (0.64 to 0.90 mg/L) concentrations generally represented about 40 percent of the TN concentration at each bridge and were similar to annual volume-weighted mean concentrations of nitrogen in precipitation in Massachusetts.Nonparametric statistical methods were used to test for differences between sample constituent concentrations among the three bridges. These results indicated that there are no statistically significant differences for concentrations of SS, LOI, PC, and TP among the three bridges (one-way analysis of variance test on rank-transformed data, 95-percent confidence level). Test results for concentrations of TN in composite samples indicated that concentrations of TN collected on State Route 20 near Quinsigamond Village were significantly higher than those concentrations collected on State Route 2A in Boston and Interstate 90 near Weston. Median concentrations of TN were about 93 and 55 percent lower at State Route 2A and at Interstate 90, respectively, compared to the median concentrations of TN at State Route 20.Samples of sediment were collected from five fixed locations on each bridge on three occasions during dry weather to calculate semiquantitative distributions of sediment yields on the bridge surface relative to the monitoring location. Mean yields of bridge-deck sediment during this study for State Route 2A in Boston, Interstate 90 near Weston, and State Route 20 near Quinsigamond Village were 1,500, 250, and 5,700 pounds per curb-mile, respectively. Sediment yields at each sampling location varied widely (26 to 25,000 pounds per curb-mile) but were similar to yields reported elsewhere in Massachusetts and the United States. Yields calculated for each sampling location indicated that the sediment was not evenly distributed across each bridge in this study for plausible reasons such as bridge slope, vehicular tracking, and bridge deterioration.Bridge-deck sediment quality was largely affected by the distribution of sediment particle size. Concentrations of TP in the fine sediment-size fraction (less than 0.0625 millimeter in diameter) of samples of bridge-deck sediment were about 6 times greater than in the coarse size fraction. Concentrations for many total-recoverable metals were 2 to 17 times greater in the fine size fraction compared to concentrations in the coarse size fraction (greater than or equal to 0.25 millimeter in diameter), and concentrations of total-recoverable copper and lead in the fine size fraction were 2 to 65 times higher compared to concentrations in the intermediate (greater than or equal to 0.0625 to 0.25 millimeter in diameter) or the coarse size fraction. However, the proportion of sediment particles less than 0.0625 millimeter in diameter in composite samples of bridge-deck runoff was small (median values range from 4 to 8 percent at each bridge) compared to the larger sediment particle-size mass. As a result, more than 50 percent of the sediment-associated TP, aluminum, chromium, manganese, and nickel was estimated to be associated with the coarse size fraction of the SS load. In contrast, about 95 percent of the estimated sediment-associated copper concentration was associated with the fine size fraction of the SS load.Version 1.0.2 of the Stochastic Empirical Loading and Dilution Model was used to simulate long-term (29–30-year) concentrations and annual yields of SS, TP, and TN in bridge-deck runoff and in discharges from a hypothetical stormwater treatment best-management practice structure. Three methods (traditional statistics, robust statistics, and L-moments) were used to calculate statistics for stochastic simulations because the high variability in measured concentration values during the field study resulted in extreme simulated concentrations. Statistics of each dataset, including the average, standard deviation, and skew of the common (base 10) logarithms, for each of the three bridges, and for a lumped dataset, were calculated and used for simulations; statistics representing the median of statistics calculated for the three bridges also were used for simulations. These median statistics were selected for the interpretive simulations so that the simulations could be used to estimate concentrations and yields from other, unmonitored bridges in Massachusetts. Comparisons of the standard and robust statistics indicated that simulation results with either method would be similar, which indicated that the large variability in simulated results was not caused by a few outliers. Comparison to statistics calculated by the L-moments methods indicated that L-moments do not produce extreme concentrations; however, they also do not produce results that represent the bulk of concentration data.The runoff-quality risk analysis indicated that bridge-deck runoff would exceed discharge standards commonly used for large, advanced wastewater treatment plants, but that commonly used stormwater best-management practices may reduce the percentage of exceedances by one-half. Results of simulations indicated that long-term average yields of TN, TP, and SS may be about 21.4, 6.44, and 40,600 pounds per acre per year, respectively. These yields are about 1.3, 3.4, and 16 times simulated ultra-urban highway yields in Massachusetts; however, simulations indicated that use of a best-management practice structure to treat bridge-deck runoff may reduce discharge yields to about 10, 2.8, and 4,300, pounds per acre per year, respectively.
Cottrell, Susan; Donaldson, Jayne H
2013-05-01
To explore the opinions of registered nurses on the Learnbloodtransfusion Module 1: Safe Transfusion Practice e-learning programme to meeting personal learning styles and learning needs. A qualitative research methodology was applied based on the principles of phenomenology. Adopting a convenience sampling plan supported the recruitment of participants who had successfully completed the e-learning course. Thematic analysis from the semi-structured interviews identified common emerging themes through application of Colaizzis framework. Seven participants of total sample population (89) volunteered to participate in the study. Five themes emerged which included learning preferences, interactive learning, course design, patient safety and future learning needs. Findings positively show the e-learning programme captures the learning styles and needs of learners. In particular, learning styles of a reflector, theorist and activist as well as a visual learner can actively engage in the online learning experience. In an attempt to bridge the knowledge practice gap, further opinions are offered on the course design and the application of knowledge to practice following completion of the course. The findings of the small scale research study have shown that the e-learning course does meet the diverse learning styles and needs of nurses working in a clinical transfusion environment. However, technology alone is not sufficient and a blended approach to learning must be adopted to meet bridging the theory practice gap supporting the integration of knowledge to clinical practice. Copyright © 2013 Elsevier Ltd. All rights reserved.
DOT National Transportation Integrated Search
2010-01-01
The Michigan Department of Transportation (MDOT) Office of Research and Best Practices : (ORBP) hosted a peer exchange December 7-9, 2010 in Lansing, Michigan. Representatives : from MDOT, five state DOTs, The Turner-Fairbank Highway Research Center,...
Research on Professional Development Schools. Teacher Education Yearbook VII.
ERIC Educational Resources Information Center
Byrd, David M., Ed.; McIntyre, D. John, Ed.
This book examines the current standard practice of confining teacher preparation to 4 years of coursework, examining the growing interest in career-spanning teacher education. There are 12 chapters. Section 1, "Collaboration: Building Bridges to Transform Institutional Cultures," includes: "Overview and Framework" (Linda…
Drilled shaft bridge foundation design parameters and procedures for bearing in SGC soils.
DOT National Transportation Integrated Search
2006-04-01
This report provides a simplified method to be used for evaluating the skin friction and tip resistance of : axially loaded drilled shafts. A summary of literature and current practice was completed and then a : comprehensive set of field and laborat...
Teacher Education. Case Studies in TESOL Practice Series.
ERIC Educational Resources Information Center
Johnson, Karen E., Ed.
Chapters in this volume include the following: "Innovations in TESOL Teacher Education: A Quiet Revolution" (Karen E. Johnson); "Building Bridges among University, School, and Community" (Donald F. Hones); "Sustainable Strategies for Professional Development in Education Reform" (Nancy Clair, Carolyn Temple Adger); "Developing Professionals:…
Using Technology in Pre-School Education
ERIC Educational Resources Information Center
Can-Yasar, Munevver; Inal, Gozde; Uyanik, Ozgun; Kandir, Adalet
2012-01-01
Technology is the collection of machines, processes, methods, transactions, systems, administration and supervision mechanism, which serves as a bridge between science and practice and helps meet human needs using available information, materials, sources and energy. The developments in technology and educational aims follow a parallelism, which…
Investigation of best practices for maintenance of concrete bridge railings : [tech summary].
DOT National Transportation Integrated Search
2015-01-01
The development of bio lms on concrete structures has a negative impact on aesthetics as well as on the performance and integrity : of concrete structures. Bio lms develop and grow easily when the right conditions are present, such as high rela...
Bridging Emotion Research: From Biology to Social Structure
ERIC Educational Resources Information Center
Rogers, Kimberly B.; Kavanagh, Liam
2010-01-01
Emotion research demonstrates that problems of theoretical interest or practical significance are not divided neatly along disciplinary boundaries. Researchers acknowledge both organic and social underpinnings of emotion, but the intersections between biological and structural processes can be difficult to negotiate. In this article, the authors…
Modeling Violent Non-State Actors: A Summary of Concepts and Methods
2004-11-01
charts, leadership, rules, formal communications and process efficiency to name a few. While a useful aspect of organizational diagnosis , this...and Arie Shirom, Organizational Diagnosis and Assessment: Bridging Theory and Practice (Thousand Oaks, CA: Sage Publications, 1999), 44. 9 Katz and
Turbulent Arena: Global Effects Against Non-State Adversaries
2005-06-01
process efficiency to name a few. While a useful aspect of organizational diagnosis , this closed system approach neglects the simple reality that an... Organizational Diagnosis and Assessment: Bridging Theory and Practice (Thousand Oaks, CA: Sage Publications, 1999), 44. 13 Katz and Kahn, 262. 14 Daft
Non-destructive and destructive investigation of aged-in-the field carbon FRP-wrapped columns.
DOT National Transportation Integrated Search
2011-06-01
The common practice of applying deicing salts on highway bridges increases the potential of reinforcing steel in these structures to experience extensive corrosion in the decks as well as the substructure. A new rehabilitation method which is believe...
A Qualitative Study of Patient and Provider Experiences during Preoperative Care Transitions
MALLEY, ANN; YOUNG, GARY J.
2017-01-01
Aims To explore the issues and challenges of care transitions in the preoperative environment. Background Ineffective transitions play a role in a majority of serious medical errors. There is a paucity of research related to the preoperative arena and the multiple inherent transitions in care that occur there. Design Qualitative descriptive design was used. Methods Semi-structured interviews were conducted in a 975 bed academic medical center. Results 30 providers and 10 preoperative patients participated. Themes that arose were: (1) Need for clarity of purpose of preoperative care (2) Care coordination (3) Inter-professional boundaries of care (4) Inadequate time and resources. Conclusion Effective transitions in the preoperative environment require that providers bridge scope of practice barriers to promote good teamwork. Preoperative care that is a product of well-informed providers and patients can improve the entire perioperative care process and potentially influence post-operative patient outcomes. Relevance to Clinical Practice Nurses are well positioned to bridge the gaps within transitions of care and accordingly affect health outcomes. PMID:27706872
Lindner, Oliver; Pascual, Thomas N B; Mercuri, Mathew; Acampa, Wanda; Burchert, Wolfgang; Flotats, Albert; Kaufmann, Philipp A; Kitsiou, Anastasia; Knuuti, Juhani; Underwood, S Richard; Vitola, João V; Mahmarian, John J; Karthikeyan, Ganesan; Better, Nathan; Rehani, Madan M; Kashyap, Ravi; Dondi, Maurizio; Paez, Diana; Einstein, Andrew J
2016-04-01
Nuclear cardiology is widely used to diagnose coronary artery disease and to guide patient management, but data on current practices, radiation dose-related best practices, and radiation doses are scarce. To address these issues, the IAEA conducted a worldwide study of nuclear cardiology practice. We present the European subanalysis. In March 2013, the IAEA invited laboratories across the world to document all SPECT and PET studies performed in one week. The data included age, gender, weight, radiopharmaceuticals, injected activities, camera type, positioning, hardware and software. Radiation effective dose was calculated for each patient. A quality score was defined for each laboratory as the number followed of eight predefined best practices with a bearing on radiation exposure (range of quality score 0 - 8). The participating European countries were assigned to regions (North, East, South, and West). Comparisons were performed between the four European regions and between Europe and the rest-of-the-world (RoW). Data on 2,381 European patients undergoing nuclear cardiology procedures in 102 laboratories in 27 countries were collected. A cardiac SPECT study was performed in 97.9 % of the patients, and a PET study in 2.1 %. The average effective dose of SPECT was 8.0 ± 3.4 mSv (RoW 11.4 ± 4.3 mSv; P < 0.001) and of PET was 2.6 ± 1.5 mSv (RoW 3.8 ± 2.5 mSv; P < 0.001). The mean effective doses of SPECT and PET differed between European regions (P < 0.001 and P = 0.002, respectively). The mean quality score was 6.2 ± 1.2, which was higher than the RoW score (5.0 ± 1.1; P < 0.001). Adherence to best practices did not differ significantly among the European regions (range 6 to 6.4; P = 0.73). Of the best practices, stress-only imaging and weight-adjusted dosing were the least commonly used. In Europe, the mean effective dose from nuclear cardiology is lower and the average quality score is higher than in the RoW. There is regional variation in effective dose in relation to the best practice quality score. A possible reason for the differences between Europe and the RoW could be the safety culture fostered by actions under the Euratom directives and the implementation of diagnostic reference levels. Stress-only imaging and weight-adjusted activity might be targets for optimization of European nuclear cardiology practice.
Demb, Joshua; Chu, Philip; Nelson, Thomas; Hall, David; Seibert, Anthony; Lamba, Ramit; Boone, John; Krishnam, Mayil; Cagnon, Christopher; Bostani, Maryam; Gould, Robert; Miglioretti, Diana; Smith-Bindman, Rebecca
2017-06-01
Radiation doses for computed tomography (CT) vary substantially across institutions. To assess the impact of institutional-level audit and collaborative efforts to share best practices on CT radiation doses across 5 University of California (UC) medical centers. In this before/after interventional study, we prospectively collected radiation dose metrics on all diagnostic CT examinations performed between October 1, 2013, and December 31, 2014, at 5 medical centers. Using data from January to March (baseline), we created audit reports detailing the distribution of radiation dose metrics for chest, abdomen, and head CT scans. In April, we shared reports with the medical centers and invited radiology professionals from the centers to a 1.5-day in-person meeting to review reports and share best practices. We calculated changes in mean effective dose 12 weeks before and after the audits and meeting, excluding a 12-week implementation period when medical centers could make changes. We compared proportions of examinations exceeding previously published benchmarks at baseline and following the audit and meeting, and calculated changes in proportion of examinations exceeding benchmarks. Of 158 274 diagnostic CT scans performed in the study period, 29 594 CT scans were performed in the 3 months before and 32 839 CT scans were performed 12 to 24 weeks after the audit and meeting. Reductions in mean effective dose were considerable for chest and abdomen. Mean effective dose for chest CT decreased from 13.2 to 10.7 mSv (18.9% reduction; 95% CI, 18.0%-19.8%). Reductions at individual medical centers ranged from 3.8% to 23.5%. The mean effective dose for abdominal CT decreased from 20.0 to 15.0 mSv (25.0% reduction; 95% CI, 24.3%-25.8%). Reductions at individual medical centers ranged from 10.8% to 34.7%. The number of CT scans that had an effective dose measurement that exceeded benchmarks was reduced considerably by 48% and 54% for chest and abdomen, respectively. After the audit and meeting, head CT doses varied less, although some institutions increased and some decreased mean head CT doses and the proportion above benchmarks. Reviewing institutional doses and sharing dose-optimization best practices resulted in lower radiation doses for chest and abdominal CT and more consistent doses for head CT.
Wald, Hedy S; George, Paul; Reis, Shmuel P; Taylor, Julie Scott
2014-03-01
While electronic health record (EHR) use is becoming state-of-the-art, deliberate teaching of health care information technology (HCIT) competencies is not keeping pace with burgeoning use. Medical students require training to become skilled users of HCIT, but formal pedagogy within undergraduate medical education (UME) is sparse. How can medical educators best meet the needs of learners while integrating EHRs into medical education and practice? How can they help learners preserve and foster effective communication skills within the computerized setting? In general, how can UME curricula be devised for skilled use of EHRs to enhance rather than hinder provision of effective, humanistic health care?Within this Perspective, the authors build on recent publications that "set the stage" for next steps: EHR curricula innovation and implementation as concrete embodiments of theoretical underpinnings. They elaborate on previous calls for maximizing benefits and minimizing risks of EHR use with sufficient focus on physician-patient communication skills and for developing core competencies within medical education. The authors describe bridging theory into practice with systematic longitudinal curriculum development for EHR training in UME at their institution, informed by Kern and colleagues' curriculum development framework, narrative medicine, and reflective practice. They consider this innovation within a broader perspective-the overarching goal of empowering undergraduate medical students' patient- and relationship-centered skills while effectively demonstrating HCIT-related skills.
An evaluation of the impact of digital imaging on radiographic practice and patient doses
NASA Astrophysics Data System (ADS)
Horrocks, J.; Violaki, K.
2015-09-01
Direct digital imaging technology was implemented in all areas in general and mobile radiology at Barts and the Royal London Hospitals in 2012. Evidence from recent radiation incident investigations indicates optimum exposure factors are not consistently selected, with the greater dynamic range of the digital detectors allowing sub-optimal practice. To investigate further patient dose data were extracted from the Radiology Information System for adult chest X-ray examinations in 2014, covering over 50,000 studies in the Trust. Chest X-ray examinations were selected as they are low dose but frequent examinations. The patient dose data were evaluated taking into account X-ray system type and detector performance measurements, and individual cases studies were used to highlight where practice can be improved.
Greenhalgh, Trisha; Russell, Jill; Myall, Michelle
2011-01-01
Objective To describe, explore, and compare organisational routines for repeat prescribing in general practice to identify contributors and barriers to safety and quality. Design Ethnographic case study. Setting Four urban UK general practices with diverse organisational characteristics using electronic patient records that supported semi-automation of repeat prescribing. Participants 395 hours of ethnographic observation of staff (25 doctors, 16 nurses, 4 healthcare assistants, 6 managers, and 56 reception or administrative staff), and 28 documents and other artefacts relating to repeat prescribing locally and nationally. Main outcome measures Potential threats to patient safety and characteristics of good practice. Methods Observation of how doctors, receptionists, and other administrative staff contributed to, and collaborated on, the repeat prescribing routine. Analysis included mapping prescribing routines, building a rich description of organisational practices, and drawing these together through narrative synthesis. This was informed by a sociological model of how organisational routines shape and are shaped by information and communications technologies. Results Repeat prescribing was a complex, technology-supported social practice requiring collaboration between clinical and administrative staff, with important implications for patient safety. More than half of requests for repeat prescriptions were classed as “exceptions” by receptionists (most commonly because the drug, dose, or timing differed from what was on the electronic repeat list). They managed these exceptions by making situated judgments that enabled them (sometimes but not always) to bridge the gap between the idealised assumptions about tasks, roles, and interactions that were built into the electronic patient record and formal protocols, and the actual repeat prescribing routine as it played out in practice. This work was creative and demanded both explicit and tacit knowledge. Clinicians were often unaware of this input and it did not feature in policy documents or previous research. Yet it was sometimes critical to getting the job done and contributed in subtle ways to safeguarding patients. Conclusion Receptionists and administrative staff make important “hidden” contributions to quality and safety in repeat prescribing in general practice, regarding themselves accountable to patients for these contributions. Studying technology-supported work routines that seem mundane, standardised, and automated, but which in reality require a high degree of local tailoring and judgment from frontline staff, opens up a new agenda for the study of patient safety. PMID:22053317
Swinglehurst, Deborah; Greenhalgh, Trisha; Russell, Jill; Myall, Michelle
2011-11-03
To describe, explore, and compare organisational routines for repeat prescribing in general practice to identify contributors and barriers to safety and quality. Ethnographic case study. Four urban UK general practices with diverse organisational characteristics using electronic patient records that supported semi-automation of repeat prescribing. 395 hours of ethnographic observation of staff (25 doctors, 16 nurses, 4 healthcare assistants, 6 managers, and 56 reception or administrative staff), and 28 documents and other artefacts relating to repeat prescribing locally and nationally. Potential threats to patient safety and characteristics of good practice. Observation of how doctors, receptionists, and other administrative staff contributed to, and collaborated on, the repeat prescribing routine. Analysis included mapping prescribing routines, building a rich description of organisational practices, and drawing these together through narrative synthesis. This was informed by a sociological model of how organisational routines shape and are shaped by information and communications technologies. Results Repeat prescribing was a complex, technology-supported social practice requiring collaboration between clinical and administrative staff, with important implications for patient safety. More than half of requests for repeat prescriptions were classed as "exceptions" by receptionists (most commonly because the drug, dose, or timing differed from what was on the electronic repeat list). They managed these exceptions by making situated judgments that enabled them (sometimes but not always) to bridge the gap between the idealised assumptions about tasks, roles, and interactions that were built into the electronic patient record and formal protocols, and the actual repeat prescribing routine as it played out in practice. This work was creative and demanded both explicit and tacit knowledge. Clinicians were often unaware of this input and it did not feature in policy documents or previous research. Yet it was sometimes critical to getting the job done and contributed in subtle ways to safeguarding patients. Conclusion Receptionists and administrative staff make important "hidden" contributions to quality and safety in repeat prescribing in general practice, regarding themselves accountable to patients for these contributions. Studying technology-supported work routines that seem mundane, standardised, and automated, but which in reality require a high degree of local tailoring and judgment from frontline staff, opens up a new agenda for the study of patient safety.
Science and Sanity in Special Education.
ERIC Educational Resources Information Center
Dammann, James E.; Vaughn, Sharon
2001-01-01
This article describes the usefulness of a scientific approach to improving knowledge and practice in special education. Of four approaches to knowledge (superstition, folklore, craft, and science), craft and science are supported and implications for special education drawn including the need to bridge the gulf between research knowledge and…
ERIC Educational Resources Information Center
Flowers, Ebony Victoria
2017-01-01
Context: Visualization as a multi-modal process is widely explored in curriculum studies. I examined a facet of how people learn to participate in visualization practices that remains under-studied in preschool and post-secondary settings: moment-to-moment agency while in unfamiliar socio-cultural realms. I conducted a thirteen-month ethnography…
Assessment of existing railroad bridges to accommodate a higher speed considering Chinese practices.
DOT National Transportation Integrated Search
2016-01-01
As the country continues to grow, the USDOT understands that the transportation system will : continue to evolve to meet the demands of the future. A balanced use of all modes of public : transportation, for both individuals and freight, will be requ...
Bridging Education and Practice with a Competency-Based Learning Contract
ERIC Educational Resources Information Center
Molina, Veronica; Molina-Moore, Tammy; Smith, Misty G.; Pratt, Francine E.
2018-01-01
Field work programs have a substantial responsibility for providing support and gatekeeping functions while ensuring an educational experience that allows students to master the nine holistic, multidimensional social work accreditation competencies. With additional emphasis on field as a "signature pedagogy," field directors are tasked…
Handbook on Measurement, Assessment, and Evaluation in Higher Education
ERIC Educational Resources Information Center
Secolsky, Charles, Ed.; Denison, D. Brian, Ed.
2011-01-01
Increased demands for colleges and universities to engage in outcomes assessment for accountability purposes have accelerated the need to bridge the gap between higher education practice and the fields of measurement, assessment, and evaluation. The "Handbook on Measurement, Assessment, and Evaluation in Higher Education" provides higher…
ERIC Educational Resources Information Center
Slingsby, David
2016-01-01
The "Journal of Biological Education" is firmly established as the authoritative voice in the world of biological education. The journal aims to bridge the gap between research and practice, providing information, ideas and opinion, in addition to critical examinations of advances in biology research and teaching. Through the coverage of…
Effective Internships: Building Bridges between Theory and Practice
ERIC Educational Resources Information Center
Cunningham, William G.; Sherman, Whitney H.
2008-01-01
Growing criticism of existing educational leadership preparation programs seems to focus on a lack of contextual relevancy and instructional leadership. Universities and school districts need to develop more formal, collaborative, long-term relationships focused on the nature of principal preparation, moving beyond acculturation to district norms…
Bridging the Gap: Contextualizing Professional Ethics in Collaborative Writing Projects
ERIC Educational Resources Information Center
Rice, J. A.
2007-01-01
Many business and technical writing students find classroom discussions of professional ethics interesting and enjoyable. However, when trying to incorporate the content of discussions directly into their writing practices, they often experience difficulties linking ethical concepts to writing process. This article discusses how instructors can…
A Guide to Effective School Leadership Theories
ERIC Educational Resources Information Center
Lynch, Matthew
2012-01-01
Educational administrators know that leadership requires hundreds of judgments each day that require a sensitivity and understanding of various leadership strategies. Bridging the gap between the academic and practical world, "A Guide to Effective School Leadership Theories" provides an exploration of ten dominant leadership strategies to give…
An External Stakeholder Analysis of a United States Army Directorate of Contracting
2004-12-01
Bass Inc., 1996. Burton, R.M. and Obel, B., Strategic Organizational Diagnosis and Design: Developing Theory for Application, 2nd ed., Kluwer...Harrison, M.I. and Shirom, A., Organizational Diagnosis and Assessment: Bridging Theory and Practice, SAGE Publications, Inc., 1999. Kotter, J.P
Three Requirements for Justifying an Educational Neuroscience
ERIC Educational Resources Information Center
Hruby, George G.
2012-01-01
Background: Over the past quarter century, efforts to bridge between research in the neurosciences and research, theory, and practice in education have grown from a mere hope to noteworthy scholarly sophistication. Many dedicated educational researchers have developed the secondary expertise in the necessary neurosciences and related fields to…
Handbook of Early Literacy Research. Volume 3
ERIC Educational Resources Information Center
Neuman, Susan B., Ed.; Dickinson, David K., Ed.
2010-01-01
Building crucial bridges between theory, research, and practice, this volume brings together leading authorities on the literacy development of young children. The "Handbook" examines the full range of factors that shape learning in and out of the classroom, from basic developmental processes to family and sociocultural contexts,…
Organizational Theory and Leadership Navigation
ERIC Educational Resources Information Center
Brazer, S. David; Kruse, Sharon D.; Conley, Sharon
2014-01-01
Teaching organizational theory in a way that bridges to leadership practice is vital to preparing deft educational leaders who understand the organizational behavior of schools and districts. Organizational theory guides understanding of the complexities of schools and districts and can be a basis for collaborative and effective decision making.…
Children with Special Needs: Perinatal Education for Adoption Workers.
ERIC Educational Resources Information Center
Vaitenas, Raminta E.
1981-01-01
Advocates adoption workers receive perinatal education so that they may be more competent in placing special needs children. Suggests a perinatal inservice program for social workers which would bridge the gap from the clinical practice setting of perinatal centers to the child welfare arena. (Author/CM)
Beat-the-wave evacuation mapping for tsunami hazards in Seaside, Oregon, USA
Priest, George R.; Stimely, Laura; Wood, Nathan J.; Madin, Ian; Watzig, Rudie
2016-01-01
Previous pedestrian evacuation modeling for tsunamis has not considered variable wave arrival times or critical junctures (e.g., bridges), nor does it effectively communicate multiple evacuee travel speeds. We summarize an approach that identifies evacuation corridors, recognizes variable wave arrival times, and produces a map of minimum pedestrian travel speeds to reach safety, termed a “beat-the-wave” (BTW) evacuation analysis. We demonstrate the improved approach by evaluating difficulty of pedestrian evacuation of Seaside, Oregon, for a local tsunami generated by a Cascadia subduction zone earthquake. We establish evacuation paths by calculating the least cost distance (LCD) to safety for every grid cell in a tsunami-hazard zone using geospatial, anisotropic path distance algorithms. Minimum BTW speed to safety on LCD paths is calculated for every grid cell by dividing surface distance from that cell to safety by the tsunami arrival time at safety. We evaluated three scenarios of evacuation difficulty: (1) all bridges are intact with a 5-minute evacuation delay from the start of earthquake, (2) only retrofitted bridges are considered intact with a 5-minute delay, and (3) only retrofitted bridges are considered intact with a 10-minute delay. BTW maps also take into account critical evacuation points along complex shorelines (e.g., peninsulas, bridges over shore-parallel estuaries) where evacuees could be caught by tsunami waves. The BTW map is able to communicate multiple pedestrian travel speeds, which are typically visualized by multiple maps with current LCD-based mapping practices. Results demonstrate that evacuation of Seaside is problematic seaward of the shore-parallel waterways for those with any limitations on mobility. Tsunami vertical-evacuation refuges or additional pedestrian bridges may be effective ways of reducing loss of life seaward of these waterways.
NASA Astrophysics Data System (ADS)
Hester, David; González, Arturo
2017-06-01
Given the large number of bridges that currently have no instrumentation, there are obvious advantages in monitoring the condition of a bridge by analysing the response of a vehicle crossing it. As a result, the last two decades have seen a rise in the research attempting to solve the problem of identifying damage in a bridge from vehicle measurements. This paper examines the theoretical feasibility and practical limitations of a drive-by system in identifying damage associated to localised stiffness losses. First, the nature of the damage feature that is sought within the vehicle response needs to be characterized. For this purpose, the total vehicle response is considered to be made of 'static' and 'dynamic' components, and where the bridge has experienced a localised loss in stiffness, an additional 'damage' component. Understanding the nature of this 'damage' component is crucial to have an informed discussion on how damage can be identified and localised. Leveraging this new understanding, the authors propose a wavelet-based drive-by algorithm. By comparing the effect of the 'damage' component to other key effects defining the measurements such as 'vehicle speed', the 'road profile' and 'noise' on a wavelet contour plot, it is possible to establish if there is a frequency range where drive-by can be successful. The algorithm uses then specific frequency bands to improve the sensitivity to damage with respect to limitations imposed by Vehicle-Bridge vibrations. Recommendations on the selection of the mother wavelet and frequency band are provided. Finally, the paper discusses the impact of noise and road profile on the ability of the approach to identify damage and how periodic measurements can be effective at monitoring localised stiffness changes.
Design and characterization of a piezoelectric sensor for monitoring scour hole evolution
NASA Astrophysics Data System (ADS)
Azhari, Faezeh; Tom, Caroline; Benassini, Joseph; Loh, Kenneth J.; Bombardelli, Fabian A.
2014-03-01
Scour occurring near bridge piers and abutments jeopardizes the stability and safety of overwater bridges. In fact, bridge scour is responsible for a significant portion of overwater bridge failures in the United States and around the world. As a result, numerous methods have been developed for monitoring bridge scour by measuring scour depth at locations near bridge piers and foundations. Besides visual inspections conducted by trained divers, other technologies include sonar, float-out devices, magnetic sliding collars, tilt sensors, and fiber optics, to name a few. These systems each offer unique advantages, but most of them share fundamental limitations (e.g., high costs, low reliability, limited accuracy, low reliability, etc.) that have limited their implementation in practice. Thus, the goal of this study is to present a low-cost and simple scour depth sensor fabricated using piezoelectric poly(vinylidene fluoride) (PVDF) polymer strips. Unlike current piezoelectric scour sensors that are based on mounting multiple and equidistantly spaced transducers on a rod, the proposed sensor is formed by coating one continuous PVDF film onto a substrate, followed by waterproofing the sensor. The PVDF-based sensor can then be buried in the streambed and at a location where scour depth measurements are desired. When scour occurs and exposes a portion of the PVDF sensor, water flow excites the sensor to cause the generation of a time-varying voltage signal. Since the dynamics of the voltage time history response is related to the exposed length of the sensor, scour depth can be determined. This work presents the design and fabrication of the sensor. Then, the sensor's performance and accuracy is characterized through extensive laboratory testing.
Faas, A J; Velez, Anne-Lise K; FitzGerald, Clare; Nowell, Branda L; Steelman, Toddi A
2017-07-01
The roles of bridging actors in emergency response networks can be important to disaster response outcomes. This paper is based on an evaluation of wildfire preparedness and response networks in 21 large-scale wildfire events in the wildland-urban interface near national forests in the American Northwest. The study investigated how key individuals in responder networks anticipated seeking out specific people in perceived bridging roles prior to the occurrence of wildfires, and then captured who in fact assumed these roles during actual large-scale events. It examines two plausible, but contradictory, bodies of theory-similarity and dissimilarity-that suggest who people might seek out as bridgers and who they would really go to during a disaster. Roughly one-half of all pre-fire nominations were consistent with similarity. Yet, while similarity is a reliable indicator of how people expect to organise, it does not hold up for how they organise during the real incident. © 2017 The Author(s). Disasters © Overseas Development Institute, 2017.
Low-temperature direct heterogeneous bonding of polyether ether ketone and platinum.
Fu, Weixin; Shigetou, Akitsu; Shoji, Shuichi; Mizuno, Jun
2017-10-01
Direct heterogeneous bonding between polyether ether ketone (PEEK) and Pt was realized at the temperatures lower than 150°C. In order to create sufficient bondability to diverse materials, the surface was modified by vacuum ultraviolet (VUV) irradiation, which formed hydrate bridges. For comparison, direct bonding between surfaces atomically cleaned via Ar fast atom bombardment (FAB) was conducted in a vacuum. The VUV irradiation was found to be effective for creating an ultrathin hydrate bridge layer from the residual water molecules in the chamber. Tight bonds were formed through dehydration of the hydrate bridges by heating at 150°C, which also contributed to enhancing interdiffusion across the interface. The VUV-modified surfaces showed bondability as good as that of the FAB-treated surfaces, and the VUV-modified samples had shear strengths at the same level as those of FAB-treated surfaces. This technology will be of practical use in the packaging of lightweight, flexible biomedical devices. Copyright © 2017 Elsevier B.V. All rights reserved.
Szostak, Roman; Aubé, Jeffrey; Szostak, Michal
2015-08-21
Twisted amides containing nitrogen at the bridgehead position are attractive practical prototypes for the investigation of the electronic and structural properties of nonplanar amide linkages. Changes that occur during rotation around the N-C(O) axis in one-carbon-bridged twisted amides have been studied using ab initio molecular orbital methods. Calculations at the MP2/6-311++G(d,p) level performed on a set of one-carbon-bridged lactams, including 20 distinct scaffolds ranging from [2.2.1] to [6.3.1] ring systems, with the C═O bond on the shortest bridge indicate significant variations in structures, resonance energies, proton affinities, core ionization energies, frontier molecular orbitals, atomic charges, and infrared frequencies that reflect structural changes corresponding to the extent of resonance stabilization during rotation along the N-C(O) axis. The results are discussed in the context of resonance theory and activation of amides toward N-protonation (N-activation) by distortion. This study demonstrates that one-carbon-bridged lactams-a class of readily available, hydrolytically robust twisted amides-are ideally suited to span the whole spectrum of the amide bond distortion energy surface. Notably, this study provides a blueprint for the rational design and application of nonplanar amides in organic synthesis. The presented findings strongly support the classical amide bond resonance model in predicting the properties of nonplanar amides.
Damage Detection Sensitivity of a Vehicle-based Bridge Health Monitoring System
NASA Astrophysics Data System (ADS)
Miyamoto, Ayaho; Yabe, Akito; Lúcio, Válter J. G.
2017-05-01
As one solution to the problem for condition assessment of existing short and medium span (10-30m) reinforced/prestressed concrete bridges, a new monitoring method using a public bus as part of a public transit system (called “Bus monitoring system”) was proposed, along with safety indices, namely, “characteristic deflection”, which is relatively free from the influence of dynamic disturbances due to such factors as the roughness of the road surface, and a structural anomaly parameter. In this study, to evaluate the practicality of the newly developed bus monitoring system, it has been field-tested over a period of about four years by using an in-service fixed-route bus operating on a bus route in the city of Ube, Yamaguchi Prefecture, Japan. In here, although there are some useful monitoring methods for short and medium span bridges based on the qualitative or quantitative information, the sensitivity of damage detection was newly discussed for safety assessment based on long term health monitoring data. The verification results thus obtained are also described in this paper, and also evaluates the sensitivity of the “characteristic deflection”, which is a bridge (health) condition indicator used by the bus monitoring system, in damage detection. Sensitivity of “characteristic deflection” is verified by introducing artificial damage into a bridge that has ended its service life and is awaiting removal. Furthermore, the sensitivity of “characteristic deflection” is verified by 3D FEM analysis.
Conformity of commercial oral single solid unit dose packages in hospital pharmacy practice.
Thibault, Maxime; Prot-Labarthe, Sonia; Bussières, Jean-François; Lebel, Denis
2008-06-01
There are limited published data on the labelling of single unit dose packages in hospitals. The study was conducted in three large hospitals (two adult and one paediatric) in the metropolitan Montreal area, Quebec, Canada. The objective is to evaluate the labelling of commercial oral single solid unit dose packages available in Canadian urban hospital pharmacy practice. The study endpoint was the labelling conformity of each unit dose package for each criterion and overall for each manufacturer. Complete labelling of unit dose packages should include the following information: (1) brand name, (2) international non-proprietary name or generic name, (3) dosage, (4) pharmaceutical form, (5) manufacturer's name, (6) expiry date, (7) batch number and (8) drug identification number. We also evaluated the ease with which a single unit dose package is detached from a multiple unit dose package for quick, easy and safe use by pharmacy staff. Conformity levels were compared between brand-name and generic packages. A total of 124 different unit dose packages were evaluated. The level of conformity of each criterion varied between 19 and 50%. Only 43% of unit dose packages provided an easy-to-detach system for single doses. Among the 14 manufacturers with three or more unit dose packages evaluated, eight (57%) had a conformity level less than 50%. This study describes the conformity of commercial oral single solid unit dose packages in hospital pharmacy practice in Quebec. A large proportion of unit dose packages do not conform to a set of nine criteria set out in the guidelines of the American Society of Health-System Pharmacists and the Canadian Society of Hospital Pharmacists.
Ubiquitous health in practice: the interreality paradigm.
Gaggioli, Andrea; Raspelli, Simona; Grassi, Alessandra; Pallavicini, Federica; Cipresso, Pietro; Wiederhold, Brenda K; Riva, Giuseppe
2011-01-01
In this paper we introduce a new ubiquitous computing paradigm for behavioral health care: "Interreality". Interreality integrates assessment and treatment within a hybrid environment, that creates a bridge between the physical and virtual worlds. Our claim is that bridging virtual experiences (fully controlled by the therapist, used to learn coping skills and emotional regulation) with real experiences (allowing both the identification of any critical stressors and the assessment of what has been learned) using advanced technologies (virtual worlds, advanced sensors and PDA/mobile phones) may improve existing psychological treatment. To illustrate the proposed concept, a clinical scenario is also presented and discussed: Daniela, a 40 years old teacher, with a mother affected by Alzheimer's disease.
ERIC Educational Resources Information Center
Academy for Educational Development, Washington, DC. National Adult Literacy and Learning Disabilities Center.
These five guidebooks are designed for literacy programs to enhance the quality of services provided to adults with learning disabilities. Each guidebook answers specific questions such as handling legal issues, screening for learning disabilities, selecting curriculum options, using effective instructional methods, and creating professional…
Postcolonial Perspectives on Global Citizenship Education. Routledge Research in Education
ERIC Educational Resources Information Center
de Oliveira Andreotti, Vanessa, Ed.; de Souza, Lynn Mario T. M., Ed.
2011-01-01
This volume bridges the gap between contemporary theoretical debates and educational policies and practices. It applies postcolonial theory as a framework of analysis that attempts to engage with and go beyond essentialism, ethno- and euro-centrisms through a critical examination of contemporary case studies and conceptual issues. From a…
Bridging CALL & HCI: Input from Participatory Design
ERIC Educational Resources Information Center
Cardenas-Claros, Monica S.; Gruba, Paul A.
2010-01-01
Participatory design (PD), or the collaboration between software engineers and end users throughout the design process, may help improve CALL design practices. In this case study, four ESL learners, a software designer, and a language teacher created and evaluated a series of paper prototypes concerning help options in computer-based second…
Workplace Learning to Create Social Quality
ERIC Educational Resources Information Center
Thijssen, Thomas
2014-01-01
Purpose: The present study aims to focus on workplace learning and understanding learning as creation (Kessels, 1995, 1996, 2001; Verdonschot, 2009; Billett and Choy, 2013) to bridge the gap between education and practice addressing the complex real world issue of poverty and social exclusion in The Netherlands. When researchers and practitioners…
UK Experiences and Lessons Identified Using C-BML in Practical Experiments
2014-06-01
network standards. Simple, unclassified networking has been conducted very successfully using OpenVPN [11] tunnels across the internet, even using...relatively low-bandwidth 3G cell-phone bridges. OpenVPN was used for much of the work of MSG-048 and -085. Experimentation has also been conducted using
The Publishing Culture and the Literary Culture.
ERIC Educational Resources Information Center
Solotaroff, Ted
1984-01-01
Argues that traditional bridges between the literary culture and publishing culture have increasingly weakened in past decade. The publishing culture has become like that of big business, marked by effort to standardize product, distribution, and consumer, and the advent of bookstore chains has put into practice the mass-merchandising system.…
A Hybrid Approach for Translational Research
ERIC Educational Resources Information Center
Webster, Yue Wang
2010-01-01
Translational research has proven to be a powerful process that bridges the gap between basic science and medical practice. The complexity of translational research is two-fold: integration of vast amount of information in disparate silos, and dissemination of discoveries to stakeholders with different interests. We designed and implemented a…
Universal Design: Online Educational Media for Students with Disabilities
ERIC Educational Resources Information Center
Sapp, Wendy
2009-01-01
The Universal eLearner is an online integrated learning module, under development, that incorporates accessible technology, universal design for learning, and best practices for online education. The American Foundation for the Blind and Bridge Multimedia have just completed a three-year grant through the National Institute on Disability and…
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Fortune, Tracy; Ennals, Priscilla; Bhopti, Anoo; Neilson, Cheryl; Darzins, Susan; Bruce, Christopher
2016-01-01
The performative context of higher education demands that practice-oriented academics shift their priorities from preparing practitioners for the profession, towards "productive" scholarship. We present narratives from occupational therapy academics at the end of a year-long journey through an action research project focussed on academic…
Indigenous Knowledge in the Sciences and a Practical Application in the Super Saturday Project.
ERIC Educational Resources Information Center
Settee, Priscilla
This paper reviews books and research papers concerned with Indigenous science knowledge and its integration into school curricula and describes current efforts to bridge Western and Native science. "A Yupiaq World View: Implications for Cultural, Educational and Technological Adaptation in a Contemporary World" (Angayuqaq Oscar…
Becoming S.T.A.R.S: Students and Teachers Achieving Reading Success
ERIC Educational Resources Information Center
Fello, Susan E.
2010-01-01
The International Reading Association (2003) has recently established new guidelines for graduate students enrolled in reading and literacy programs. These guidelines require graduate students to maintain direct contact with students during their coursework for advanced degrees. Field experiences support best practices in bridging the gap between…
Bridging Language Barriers in Multilingual Care Encounters
ERIC Educational Resources Information Center
Jansson, Gunilla
2014-01-01
The present case study demonstrates how the multilingual practices of a linguistically diverse workforce contribute to the functioning of a modern workplace. Based on ethnographic fieldwork and recordings in a residential home for elderly people with dementia in Sweden, the article explores how multilingual immigrant care workers creatively use…