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Sample records for double auction mechanism

  1. A Greedy Double Auction Mechanism for Grid Resource Allocation

    NASA Astrophysics Data System (ADS)

    Ding, Ding; Luo, Siwei; Gao, Zhan

    To improve the resource utilization and satisfy more users, a Greedy Double Auction Mechanism(GDAM) is proposed to allocate resources in grid environments. GDAM trades resources at discriminatory price instead of uniform price, reflecting the variance in requirements for profits and quantities. Moreover, GDAM applies different auction rules to different cases, over-demand, over-supply and equilibrium of demand and supply. As a new mechanism for grid resource allocation, GDAM is proved to be strategy-proof, economically efficient, weakly budget-balanced and individual rational. Simulation results also confirm that GDAM outperforms the traditional one on both the total trade amount and the user satisfaction percentage, specially as more users are involved in the auction market.

  2. Efficient Double Auction Mechanisms in the Energy Grid with Connected and Islanded Microgrids

    NASA Astrophysics Data System (ADS)

    Faqiry, Mohammad Nazif

    The future energy grid is expected to operate in a decentralized fashion as a network of autonomous microgrids that are coordinated by a Distribution System Operator (DSO), which should allocate energy to them in an efficient manner. Each microgrid operating in either islanded or grid-connected mode may be considered to manage its own resources. This can take place through auctions with individual units of the microgrid as the agents. This research proposes efficient auction mechanisms for the energy grid, with is-landed and connected microgrids. The microgrid level auction is carried out by means of an intermediate agent called an aggregator. The individual consumer and producer units are modeled as selfish agents. With the microgrid in islanded mode, two aggregator-level auction classes are analyzed: (i) price-heterogeneous, and (ii) price homogeneous. Under the price heterogeneity paradigm, this research extends earlier work on the well-known, single-sided Kelly mechanism to double auctions. As in Kelly auctions, the proposed algorithm implements the bidding without using any agent level private infor-mation (i.e. generation capacity and utility functions). The proposed auction is shown to be an efficient mechanism that maximizes the social welfare, i.e. the sum of the utilities of all the agents. Furthermore, the research considers the situation where a subset of agents act as a coalition to redistribute the allocated energy and price using any other specific fairness criterion. The price homogeneous double auction algorithm proposed in this research ad-dresses the problem of price-anticipation, where each agent tries to influence the equilibri-um price of energy by placing strategic bids. As a result of this behavior, the auction's efficiency is lowered. This research proposes a novel approach that is implemented by the aggregator, called virtual bidding, where the efficiency can be asymptotically maximized, even in the presence of price anticipatory bidders

  3. Statistical theory of the continuous double auction

    NASA Astrophysics Data System (ADS)

    Smith, Eric; Doyne Farmer, J.; Gillemot, László; Krishnamurthy, Supriya

    2003-12-01

    Most modern financial markets use a continuous double auction mechanism to store and match orders and facilitate trading. In this paper we develop a microscopic dynamical statistical model for the continuous double auction under the assumption of IID random order flow, and analyse it using simulation, dimensional analysis, and theoretical tools based on mean field approximations. The model makes testable predictions for basic properties of markets, such as price volatility, the depth of stored supply and demand versus price, the bid-ask spread, the price impact function, and the time and probability of filling orders. These predictions are based on properties of order flow and the limit order book, such as share volume of market and limit orders, cancellations, typical order size, and tick size. Because these quantities can all be measured directly there are no free parameters. We show that the order size, which can be cast as a non-dimensional granularity parameter, is in most cases a more significant determinant of market behaviour than tick size. We also provide an explanation for the observed highly concave nature of the price impact function. On a broader level, this work suggests how stochastic models based on zero intelligence agents may be useful to probe the structure of market institutions. Like the model of perfect rationality, a stochastic zero intelligence model can be used to make strong predictions based on a compact set of assumptions, even if these assumptions are not fully believable.

  4. Poisson-process generalization for the trading waiting-time distribution in a double-auction mechanism

    NASA Astrophysics Data System (ADS)

    Cincotti, Silvano; Ponta, Linda; Raberto, Marco; Scalas, Enrico

    2005-05-01

    In this paper, empirical analyses and computational experiments are presented on high-frequency data for a double-auction (book) market. Main objective of the paper is to generalize the order waiting time process in order to properly model such empirical evidences. The empirical study is performed on the best bid and best ask data of 7 U.S. financial markets, for 30-stock time series. In particular, statistical properties of trading waiting times have been analyzed and quality of fits is evaluated by suitable statistical tests, i.e., comparing empirical distributions with theoretical models. Starting from the statistical studies on real data, attention has been focused on the reproducibility of such results in an artificial market. The computational experiments have been performed within the Genoa Artificial Stock Market. In the market model, heterogeneous agents trade one risky asset in exchange for cash. Agents have zero intelligence and issue random limit or market orders depending on their budget constraints. The price is cleared by means of a limit order book. The order generation is modelled with a renewal process. Based on empirical trading estimation, the distribution of waiting times between two consecutive orders is modelled by a mixture of exponential processes. Results show that the empirical waiting-time distribution can be considered as a generalization of a Poisson process. Moreover, the renewal process can approximate real data and implementation on the artificial stocks market can reproduce the trading activity in a realistic way.

  5. Statistical Mechanics of Combinatorial Auctions

    NASA Astrophysics Data System (ADS)

    Galla, Tobias; Leone, Michele; Marsili, Matteo; Sellitto, Mauro; Weigt, Martin; Zecchina, Riccardo

    2006-09-01

    Combinatorial auctions are formulated as frustrated lattice gases on sparse random graphs, allowing the determination of the optimal revenue by methods of statistical physics. Transitions between computationally easy and hard regimes are found and interpreted in terms of the geometric structure of the space of solutions. We introduce an iterative algorithm to solve intermediate and large instances, and discuss competing states of optimal revenue and maximal number of satisfied bidders. The algorithm can be generalized to the hard phase and to more sophisticated auction protocols.

  6. Understanding Financial Market States Using an Artificial Double Auction Market.

    PubMed

    Yim, Kyubin; Oh, Gabjin; Kim, Seunghwan

    2016-01-01

    The ultimate value of theories describing the fundamental mechanisms behind asset prices in financial systems is reflected in the capacity of such theories to understand these systems. Although the models that explain the various states of financial markets offer substantial evidence from the fields of finance, mathematics, and even physics, previous theories that attempt to address the complexities of financial markets in full have been inadequate. We propose an artificial double auction market as an agent-based model to study the origin of complex states in financial markets by characterizing important parameters with an investment strategy that can cover the dynamics of the financial market. The investment strategies of chartist traders in response to new market information should reduce market stability based on the price fluctuations of risky assets. However, fundamentalist traders strategically submit orders based on fundamental value and, thereby stabilize the market. We construct a continuous double auction market and find that the market is controlled by the proportion of chartists, Pc. We show that mimicking the real state of financial markets, which emerges in real financial systems, is given within the range Pc = 0.40 to Pc = 0.85; however, we show that mimicking the efficient market hypothesis state can be generated with values less than Pc = 0.40. In particular, we observe that mimicking a market collapse state is created with values greater than Pc = 0.85, at which point a liquidity shortage occurs, and the phase transition behavior is described at Pc = 0.85.

  7. Double-Auction Market Simulation Software for Very Large Classes

    ERIC Educational Resources Information Center

    Ironside, Brian; Joerding, Wayne; Kuzyk, Pat

    2004-01-01

    The authors provide a version of a double-auction market simulation designed for classes too large for most computer labs to accommodate in one sitting. Instead, students play the game from remote computers, wherever they may be and at any time during a given time period specified by the instructor. When the window of time expires, students can…

  8. Understanding Financial Market States Using an Artificial Double Auction Market

    PubMed Central

    2016-01-01

    The ultimate value of theories describing the fundamental mechanisms behind asset prices in financial systems is reflected in the capacity of such theories to understand these systems. Although the models that explain the various states of financial markets offer substantial evidence from the fields of finance, mathematics, and even physics, previous theories that attempt to address the complexities of financial markets in full have been inadequate. We propose an artificial double auction market as an agent-based model to study the origin of complex states in financial markets by characterizing important parameters with an investment strategy that can cover the dynamics of the financial market. The investment strategies of chartist traders in response to new market information should reduce market stability based on the price fluctuations of risky assets. However, fundamentalist traders strategically submit orders based on fundamental value and, thereby stabilize the market. We construct a continuous double auction market and find that the market is controlled by the proportion of chartists, Pc. We show that mimicking the real state of financial markets, which emerges in real financial systems, is given within the range Pc = 0.40 to Pc = 0.85; however, we show that mimicking the efficient market hypothesis state can be generated with values less than Pc = 0.40. In particular, we observe that mimicking a market collapse state is created with values greater than Pc = 0.85, at which point a liquidity shortage occurs, and the phase transition behavior is described at Pc = 0.85. PMID:27031110

  9. From Walras’ auctioneer to continuous time double auctions: a general dynamic theory of supply and demand

    NASA Astrophysics Data System (ADS)

    Donier, J.; Bouchaud, J.-P.

    2016-12-01

    In standard Walrasian auctions, the price of a good is defined as the point where the supply and demand curves intersect. Since both curves are generically regular, the response to small perturbations is linearly small. However, a crucial ingredient is absent of the theory, namely transactions themselves. What happens after they occur? To answer the question, we develop a dynamic theory for supply and demand based on agents with heterogeneous beliefs. When the inter-auction time is infinitely long, the Walrasian mechanism is recovered. When transactions are allowed to happen in continuous time, a peculiar property emerges: close to the price, supply and demand vanish quadratically, which we empirically confirm on the Bitcoin. This explains why price impact in financial markets is universally observed to behave as the square root of the excess volume. The consequences are important, as they imply that the very fact of clearing the market makes prices hypersensitive to small fluctuations.

  10. Statistical mechanics of budget-constrained auctions

    NASA Astrophysics Data System (ADS)

    Altarelli, F.; Braunstein, A.; Realpe-Gomez, J.; Zecchina, R.

    2009-07-01

    Finding the optimal assignment in budget-constrained auctions is a combinatorial optimization problem with many important applications, a notable example being in the sale of advertisement space by search engines (in this context the problem is often referred to as the off-line AdWords problem). On the basis of the cavity method of statistical mechanics, we introduce a message-passing algorithm that is capable of solving efficiently random instances of the problem extracted from a natural distribution, and we derive from its properties the phase diagram of the problem. As the control parameter (average value of the budgets) is varied, we find two phase transitions delimiting a region in which long-range correlations arise.

  11. Auction Mechanism to Allocate Air Traffic Control Slots

    NASA Technical Reports Server (NTRS)

    Raffarin, Marianne

    2003-01-01

    This article deals with an auction mechanism for airspace slots, as a means of solving the European airspace congestion problem. A disequilibrium, between Air Traffic Control (ATC) services supply and ATC services demand are at the origin of almost one fourth of delays in the air transport industry in Europe. In order to tackle this congestion problem, we suggest modifying both pricing and allocation of ATC services, by setting up an auction mechanism. Objects of the auction will be the right for airlines to cross a part of the airspace, and then to benefit from ATC services over a period corresponding to the necessary time for the crossing. Allocation and payment rules have to be defined according to the objectives of this auction. The auctioneer is the public authority in charge of ATC services, whose aim is to obtain an efficient allocation. Therefore, the social value will be maximized. Another objective is to internalize congestion costs. To that end, we apply the principle of Clarke-Groves mechanism auction: each winner has to pay the externalities imposed on other bidders. The complex context of ATC leads to a specific design for this auction.

  12. Adaptive Sniping for Volatile and Stable Continuous Double Auction Markets

    NASA Astrophysics Data System (ADS)

    Toft, I. E.; Bagnall, A. J.

    This paper introduces a new adaptive sniping agent for the Continuous Double Auction. We begin by analysing the performance of the well known Kaplan sniper in two extremes of market conditions. We generate volatile and stable market conditions using the well known Zero Intelligence-Constrained agent and a new zero-intelligence agent Small Increment (SI). ZI-C agents submit random but profitable bids/offers and cause high volatility in prices and individual trader performance. Our new zero-intelligence agent, SI, makes small random adjustments to the outstanding bid/offer and hence is more cautious than ZI-C. We present results for SI in self-play and then analyse Kaplan in volatile and stable markets. We demonstrate that the non-adaptive Kaplan sniper can be configured to suit either market conditions, but no single configuration is performs well across both market types. We believe that in a dynamic auction environment where current or future market conditions cannot be predicted a viable sniping strategy should adapt its behaviour to suit prevailing market conditions. To this end, we propose the Adaptive Sniper (AS) agent for the CDA. AS traders classify sniping opportunities using a statistical model of market activity and adjust their classification thresholds using a Widrow-Hoff adapted search. Our AS agent requires little configuration, and outperforms the original Kaplan sniper in volatile and stable markets, and in a mixed trader type scenario that includes adaptive strategies from the literature.

  13. Analysis of Residential Demand Response and Double-Auction Markets

    SciTech Connect

    Fuller, Jason C.; Schneider, Kevin P.; Chassin, David P.

    2011-10-10

    Demand response and dynamic pricing programs are expected to play increasing roles in the modern Smart Grid environment. While direct load control of end-use loads has existed for decades, price driven response programs are only beginning to be explored at the distribution level. These programs utilize a price signal as a means to control demand. Active markets allow customers to respond to fluctuations in wholesale electrical costs, but may not allow the utility to control demand. Transactive markets, utilizing distributed controllers and a centralized auction can be used to create an interactive system which can limit demand at key times on a distribution system, decreasing congestion. With the current proliferation of computing and communication resources, the ability now exists to create transactive demand response programs at the residential level. With the combination of automated bidding and response strategies coupled with education programs and customer response, emerging demand response programs have the ability to reduce utility demand and congestion in a more controlled manner. This paper will explore the effects of a residential double-auction market, utilizing transactive controllers, on the operation of an electric power distribution system.

  14. Modeling and simulation of a double auction artificial financial market

    NASA Astrophysics Data System (ADS)

    Raberto, Marco; Cincotti, Silvano

    2005-09-01

    We present a double-auction artificial financial market populated by heterogeneous agents who trade one risky asset in exchange for cash. Agents issue random orders subject to budget constraints. The limit prices of orders may depend on past market volatility. Limit orders are stored in the book whereas market orders give immediate birth to transactions. We show that fat tails and volatility clustering are recovered by means of very simple assumptions. We also investigate two important stylized facts of the limit order book, i.e., the distribution of waiting times between two consecutive transactions and the instantaneous price impact function. We show both theoretically and through simulations that if the order waiting times are exponentially distributed, even trading waiting times are also exponentially distributed.

  15. Ergodic Transition in a Simple Model of the Continuous Double Auction

    PubMed Central

    Radivojević, Tijana; Anselmi, Jonatha; Scalas, Enrico

    2014-01-01

    We study a phenomenological model for the continuous double auction, whose aggregate order process is equivalent to two independent queues. The continuous double auction defines a continuous-time random walk for trade prices. The conditions for ergodicity of the auction are derived and, as a consequence, three possible regimes in the behavior of prices and logarithmic returns are observed. In the ergodic regime, prices are unstable and one can observe a heteroskedastic behavior in the logarithmic returns. On the contrary, non-ergodicity triggers stability of prices, even if two different regimes can be seen. PMID:24558377

  16. Competitive Financing Mechanisms: Auctions Used by Federal Agencies.

    ERIC Educational Resources Information Center

    Joyner, Carlotta C.

    This report reviews auctions used by various federal agencies to examine the feasibility of using similar auctions to determine interest rates for student borrowing through the Federal Family Education Loan Program (FFELP) and the William D. Ford Federal Direct Loan Program. The review identified 31 different auctions, divided into two major…

  17. Alternative Salary Auction Mechanisms for the Navy: An Experimental Program

    DTIC Science & Technology

    2007-12-01

    auctions transfer the most surplus value to the Navy. Equity is fairness among sailors, and may mean equal pay or equal benefit (surplus)3. No...values range from $40,000 to $80,000 – Each value in range equally likely – Rounded to nearest $1000 8 Willingness to Pay (WTP) • Maximum a company is...test the impact of bidding behavior on two matching mechanisms proposed by prior research for use in the U.S. Navy’s Assignment Incentive Pay (AIP

  18. A False-name-Proof Double Auction Protocol for Arbitrary Evaluation Values

    NASA Astrophysics Data System (ADS)

    Sakurai, Yuko; Yokoo, Makoto

    We develop a new false-name-proof double auction protocol called the Generalized Threshold Price Double auction (GTPD) protocol. False-name-proofness generalizes strategy-proofness by incorporating the possibility of false-name bids, e.g., bids submitted using multiple e-mail addresses. An existing protocol called TPD protocol is false-name-proof but can handle only the cases where marginal utilities of each agent always decrease, while our new GTPD protocol can handle arbitrary evaluation values. When marginal utilities can increase, some bids cannot be divided into a single unit (e.g., an all-or-nothing bid). Due to the existence of such indivisible bids, meeting supply/demand becomes difficult. Furthermore, a seller/buyer can submit a false-name-bid by pretending to be a potential buyer/seller to manipulate allocations and payments. In the GTPD protocol, the auctioneer is required to absorb the supply-demand imbalance up to a given upper-bound. Also, the GTPD incorporate a new false-name-proof one-sided auction protocol that is guaranteed to sell/buy a certain number of units. Simulation results show that when the threshold price is set appropriately, this protocol can obtain a good social surplus, and the number of absorbed units is much smaller than the given upper-bound.

  19. Learning Based Bidding Strategy for HVAC Systems in Double Auction Retail Energy Markets

    SciTech Connect

    Sun, Yannan; Somani, Abhishek; Carroll, Thomas E.

    2015-07-01

    In this paper, a bidding strategy is proposed using reinforcement learning for HVAC systems in a double auction market. The bidding strategy does not require a specific model-based representation of behavior, i.e., a functional form to translate indoor house temperatures into bid prices. The results from reinforcement learning based approach are compared with the HVAC bidding approach used in the AEP gridSMART® smart grid demonstration project and it is shown that the model-free (learning based) approach tracks well the results from the model-based behavior. Successful use of model-free approaches to represent device-level economic behavior may help develop similar approaches to represent behavior of more complex devices or groups of diverse devices, such as in a building. Distributed control requires an understanding of decision making processes of intelligent agents so that appropriate mechanisms may be developed to control and coordinate their responses, and model-free approaches to represent behavior will be extremely useful in that quest.

  20. Investor structure and the price-volume relationship in a continuous double auction market: An agent-based modeling perspective

    NASA Astrophysics Data System (ADS)

    Zhang, Wei; Bi, Zhengzheng; Shen, Dehua

    2017-02-01

    This paper investigates the impact of investor structure on the price-volume relationship by simulating a continuous double auction market. Connected with the underlying mechanisms of the price-volume relationship, i.e., the Mixture of Distribution Hypothesis (MDH) and the Sequential Information Arrival Hypothesis (SIAH), the simulation results show that: (1) there exists a strong lead-lag relationship between the return volatility and trading volume when the number of informed investors is close to the number of uninformed investors in the market; (2) as more and more informed investors entering the market, the lead-lag relationship becomes weaker and weaker, while the contemporaneous relationship between the return volatility and trading volume becomes more prominent; (3) when the informed investors are in absolute majority, the market can achieve the new equilibrium immediately. Therefore, we can conclude that the investor structure is a key factor in affecting the price-volume relationship.

  1. Mechanism Design for Multi-slot Ads Auction in Sponsored Search Markets

    NASA Astrophysics Data System (ADS)

    Deng, Xiaotie; Sun, Yang; Yin, Ming; Zhou, Yunhong

    In this paper, we study pricing models for multi-slot advertisements, where advertisers can bid to place links to their sales webpages at one or multiple slots on a webpage, called the multi-slot AD auction problem. We develop and analyze several important mechanisms, including the VCG mechanism for multi-slot ads auction, the optimal social welfare solution, as well as two weighted GSP-like protocols (mixed and hybrid). Furthermore, we consider that forward-looking Nash equilibrium and prove its existence in the weighted GSP-like pricing protocols.

  2. A novel method for strategy acquisition and its application to a double-auction market game.

    PubMed

    Phelps, Steve; McBurney, Peter; Parsons, Simon

    2010-06-01

    We introduce a method for strategy acquisition in nonzero-sum n -player games and empirically validate it by applying it to a well-known benchmark problem in this domain, namely, the double-auction market. Many existing approaches to strategy acquisition focus on attempting to find strategies that are robust in the sense that they are good all-round performers against all-comers. We argue that, in many economic and multiagent scenarios, the robustness criterion is inappropriate; in contrast, our method focuses on searching for strategies that are likely to be adopted by participating agents, which is formalized as the size of a strategy's basins of attraction under the replicator dynamics.

  3. Comparisons of auction mechanisms in a multiple unit setting: A consideration for restructuring electric power markets

    NASA Astrophysics Data System (ADS)

    Bernard, John Charles

    The objective of this study was to compare the performance of five single sided auctions that could be used in restructured electric power markets across different market sizes in a multiple unit setting. Auction selection would profoundly influence an industry over $200 billion in size in the United States, and the consequences of implementing an inappropriate mechanism would be great. Experimental methods were selected to analyze the auctions. Two rounds of experiments were conducted, the first testing the sealed offer last accepted offer (LAO) and first rejected offer (FRO), and the clock English (ENG) and sealed offer English (SOE) in markets of sizes two and six. The FRO, SOE, and ENG used the same pricing rule. Second round testing was on the LAO, FRO, and the nonuniform price multiple unit Vickrey (MUV) in markets of sizes two, four, and six. Experiments lasted 23 and 75 periods for rounds 1 and 2 respectively. Analysis of variance and contrast analysis were used to examine the data. The four performance measures used were price, efficiency, profits per unit, and supply revelation. Five basic principles were also assessed: no sales at losses, all low cost capacity should be offered and sold, no high cost capacity should sell, and the market should clear. It was expected group size and auction type would affect performance. For all performance measures, group size was a significant variable, with smaller groups showing poorer performance. Auction type was significant only for the efficiency performance measure, where clock auctions outperformed the others. Clock auctions also proved superior for the first four principles. The FRO performed poorly in almost all situations, and should not be a preferred mechanism in any market. The ENG was highly efficient, but expensive for the buyer. The SOE appeared superior to the FRO and ENG. The clock improves efficiency over the FRO while less information kept prices under the ENG. The MUV was superior in revealing costs

  4. Efficient Nash Equilibrium Resource Allocation Based on Game Theory Mechanism in Cloud Computing by Using Auction.

    PubMed

    Nezarat, Amin; Dastghaibifard, G H

    2015-01-01

    One of the most complex issues in the cloud computing environment is the problem of resource allocation so that, on one hand, the cloud provider expects the most profitability and, on the other hand, users also expect to have the best resources at their disposal considering the budget constraints and time. In most previous work conducted, heuristic and evolutionary approaches have been used to solve this problem. Nevertheless, since the nature of this environment is based on economic methods, using such methods can decrease response time and reducing the complexity of the problem. In this paper, an auction-based method is proposed which determines the auction winner by applying game theory mechanism and holding a repetitive game with incomplete information in a non-cooperative environment. In this method, users calculate suitable price bid with their objective function during several round and repetitions and send it to the auctioneer; and the auctioneer chooses the winning player based the suggested utility function. In the proposed method, the end point of the game is the Nash equilibrium point where players are no longer inclined to alter their bid for that resource and the final bid also satisfies the auctioneer's utility function. To prove the response space convexity, the Lagrange method is used and the proposed model is simulated in the cloudsim and the results are compared with previous work. At the end, it is concluded that this method converges to a response in a shorter time, provides the lowest service level agreement violations and the most utility to the provider.

  5. Evaluating the impacts of farmers' behaviors on a hypothetical agricultural water market based on double auction

    NASA Astrophysics Data System (ADS)

    Du, Erhu; Cai, Ximing; Brozović, Nicholas; Minsker, Barbara

    2017-05-01

    Agricultural water markets are considered effective instruments to mitigate the impacts of water scarcity and to increase crop production. However, previous studies have limited understanding of how farmers' behaviors affect the performance of water markets. This study develops an agent-based model to explicitly incorporate farmers' behaviors, namely irrigation behavior (represented by farmers' sensitivity to soil water deficit λ) and bidding behavior (represented by farmers' rent seeking μ and learning rate β), in a hypothetical water market based on a double auction. The model is applied to the Guadalupe River Basin in Texas to simulate a hypothetical agricultural water market under various hydrological conditions. It is found that the joint impacts of the behavioral parameters on the water market are strong and complex. In particular, among the three behavioral parameters, λ affects the water market potential and its impacts on the performance of the water market are significant under most scenarios. The impacts of μ or β on the performance of the water market depend on the other two parameters. The water market could significantly increase crop production only when the following conditions are satisfied: (1) λ is small and (2) μ is small and/or β is large. The first condition requires efficient irrigation scheduling, and the second requires well-developed water market institutions that provide incentives to bid true valuation of water permits.

  6. Emergence of Cooperative Long-Term Market Loyalty in Double Auction Markets

    PubMed Central

    Alorić, Aleksandra; Sollich, Peter; McBurney, Peter; Galla, Tobias

    2016-01-01

    Loyal buyer-seller relationships can arise by design, e.g. when a seller tailors a product to a specific market niche to accomplish the best possible returns, and buyers respond to the dedicated efforts the seller makes to meet their needs. We ask whether it is possible, instead, for loyalty to arise spontaneously, and in particular as a consequence of repeated interaction and co-adaptation among the agents in a market. We devise a stylized model of double auction markets and adaptive traders that incorporates these features. Traders choose where to trade (which market) and how to trade (to buy or to sell) based on their previous experience. We find that when the typical scale of market returns (or, at fixed scale of returns, the intensity of choice) become higher than some threshold, the preferred state of the system is segregated: both buyers and sellers are segmented into subgroups that are persistently loyal to one market over another. We characterize the segregated state analytically in the limit of large markets: it is stabilized by some agents acting cooperatively to enable trade, and provides higher rewards than its unsegregated counterpart both for individual traders and the population as a whole. PMID:27120473

  7. Emergence of Cooperative Long-Term Market Loyalty in Double Auction Markets.

    PubMed

    Alorić, Aleksandra; Sollich, Peter; McBurney, Peter; Galla, Tobias

    2016-01-01

    Loyal buyer-seller relationships can arise by design, e.g. when a seller tailors a product to a specific market niche to accomplish the best possible returns, and buyers respond to the dedicated efforts the seller makes to meet their needs. We ask whether it is possible, instead, for loyalty to arise spontaneously, and in particular as a consequence of repeated interaction and co-adaptation among the agents in a market. We devise a stylized model of double auction markets and adaptive traders that incorporates these features. Traders choose where to trade (which market) and how to trade (to buy or to sell) based on their previous experience. We find that when the typical scale of market returns (or, at fixed scale of returns, the intensity of choice) become higher than some threshold, the preferred state of the system is segregated: both buyers and sellers are segmented into subgroups that are persistently loyal to one market over another. We characterize the segregated state analytically in the limit of large markets: it is stabilized by some agents acting cooperatively to enable trade, and provides higher rewards than its unsegregated counterpart both for individual traders and the population as a whole.

  8. Evaluation of Aviation Career Pay Incentives Among the Naval Aviation Enterprise Utilizing Auction Mechanisms

    DTIC Science & Technology

    2015-03-01

    efficiently utilize the required resources and maximize combat readiness. The typical career path for a Navy aviation officer includes five stages...AVIATION CAREER PAY INCENTIVES AMONG THE NAVAL AVIATION ENTERPRISE UTILIZING AUCTION MECHANISMS by Brett M. Williams March 2015 Thesis Advisor...REPORT TYPE AND DATES COVERED March 2015 Master ’s Thesis 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS EVALUATION OF AVIATION CAREER PAY INCENTIVES

  9. A Centralized Auction Mechanism for the Disability and Survivors Insurance in Chile

    NASA Astrophysics Data System (ADS)

    Reyes H., Gonzalo

    As part of the pension reform recently approved in Chile, the government introduced a centralized auction mechanism to provide the Disability and Survivors (D&S) Insurance that covers recent contributors among the more than 8 million participants in the mandatory private pension system. This paper is intended as a case study presenting the main distortions found in the decentralized operation of the system that led to this reform and the challenges faced when designing a competitive auction mechanism to be implemented jointly by the Pension Fund Managers (AFP). In a typical bilateral contract the AFP retained much of the risk and the Insurance Company acted in practice as a reinsurer. The process to hire this contract was not competitive and colligated companies ended up providing the service. Several distortions affected competition in the market through incentives to cream-skim members by AFPs (since they bear most of the risk) or efforts to block disability claims. Since the price of this insurance is hidden in the fees charged by AFPs for the administration of individual accounts and pension funds there was lack of price transparency. Since new AFPs have no history of members’ disability and mortality profile the insurance contract acted as a barrier to entry in the market of AFP services, especially when D&S insurance costs reached 50% of total costs. Cross-subsidies between members of the same AFP, inefficient risk pooling (due to pooling occurring at the AFP rather than at the system level) and regulatory arbitrage, since AFPs provided insurance not being regulated as an insurance company, were also present. A centralized auction mechanism solves these market failures, but also gives raise to new challenges, such as how to design a competitive auction that attracts participation and deters collusion. Design features that were incorporated in the regulation to tackle these issues, such as dividing coverage into predefined percentage blocks, are presented

  10. A Hierarchical Auction-Based Mechanism for Real-Time Resource Allocation in Cloud Robotic Systems.

    PubMed

    Wang, Lujia; Liu, Ming; Meng, Max Q-H

    2017-02-01

    Cloud computing enables users to share computing resources on-demand. The cloud computing framework cannot be directly mapped to cloud robotic systems with ad hoc networks since cloud robotic systems have additional constraints such as limited bandwidth and dynamic structure. However, most multirobotic applications with cooperative control adopt this decentralized approach to avoid a single point of failure. Robots need to continuously update intensive data to execute tasks in a coordinated manner, which implies real-time requirements. Thus, a resource allocation strategy is required, especially in such resource-constrained environments. This paper proposes a hierarchical auction-based mechanism, namely link quality matrix (LQM) auction, which is suitable for ad hoc networks by introducing a link quality indicator. The proposed algorithm produces a fast and robust method that is accurate and scalable. It reduces both global communication and unnecessary repeated computation. The proposed method is designed for firm real-time resource retrieval for physical multirobot systems. A joint surveillance scenario empirically validates the proposed mechanism by assessing several practical metrics. The results show that the proposed LQM auction outperforms state-of-the-art algorithms for resource allocation.

  11. Efficient Nash Equilibrium Resource Allocation Based on Game Theory Mechanism in Cloud Computing by Using Auction

    PubMed Central

    Nezarat, Amin; Dastghaibifard, GH

    2015-01-01

    One of the most complex issues in the cloud computing environment is the problem of resource allocation so that, on one hand, the cloud provider expects the most profitability and, on the other hand, users also expect to have the best resources at their disposal considering the budget constraints and time. In most previous work conducted, heuristic and evolutionary approaches have been used to solve this problem. Nevertheless, since the nature of this environment is based on economic methods, using such methods can decrease response time and reducing the complexity of the problem. In this paper, an auction-based method is proposed which determines the auction winner by applying game theory mechanism and holding a repetitive game with incomplete information in a non-cooperative environment. In this method, users calculate suitable price bid with their objective function during several round and repetitions and send it to the auctioneer; and the auctioneer chooses the winning player based the suggested utility function. In the proposed method, the end point of the game is the Nash equilibrium point where players are no longer inclined to alter their bid for that resource and the final bid also satisfies the auctioneer’s utility function. To prove the response space convexity, the Lagrange method is used and the proposed model is simulated in the cloudsim and the results are compared with previous work. At the end, it is concluded that this method converges to a response in a shorter time, provides the lowest service level agreement violations and the most utility to the provider. PMID:26431035

  12. Reputation mechanism: From resolution for truthful online auctions to the model of optimal one-gambler problem

    SciTech Connect

    Bradonjic, Milan

    2009-01-01

    In this paper we study reputation mechanisms, and show how the notion of reputation can help us in building truthful online auction mechanisms. From the mechanism design prospective, we derive the conditions on and design a truthful online auction mechanism. Moreover, in the case when some agents may lay or cannot have the real knowledge about the other agents reputations, we derive the resolution of the auction, such that the mechanism is truthful. Consequently, we move forward to the optimal one-gambler/one-seller problem, and explain how that problem is refinement of the previously discussed online auction design in the presence of reputation mechanism. In the setting of the optimal one-gambler problem, we naturally rise and solve the specific question: What is an agent's optimal strategy, in order to maximize his revenue? We would like to stress that our analysis goes beyond the scope, which game theory usually discusses under the notion of reputation. We model one-player games, by introducing a new parameter (reputation), which helps us in predicting the agent's behavior, in real-world situations, such as, behavior of a gambler, real-estate dealer, etc.

  13. Three essays on auction markets

    NASA Astrophysics Data System (ADS)

    Shunda, Nicholas James

    This dissertation contains a series of theoretical investigations of auction markets. The essays it contains cover wholesale electricity markets, a popular selling mechanism on eBay, and supplier entry into multi-unit procurement auctions. The study in Chapter 1 compares the procurement cost-minimizing and productive efficiency performance of the auction mechanism used by independent system operators in wholesale electricity auction markets in the U.S. with that of a proposed alternative. The current practice allocates energy contracts as if the auction featured a discriminatory final payment method when, in fact, the markets are uniform price auctions. The proposed alternative explicitly accounts for the market-clearing price during the allocation phase. We find that the proposed alternative largely outperforms the current practice on the basis of procurement costs in the context of simple auction markets featuring both day-ahead and real-time auctions and that the procurement cost advantage of the alternative is complete when we simulate the effects of increased competition. We also find that a tradeoff between the objectives of procurement cost minimization and productive efficiency emerges in our simple auction markets and persists in the face of increased competition. The study in Chapter 2 considers a possible rationale for an auction with a buy price. In an auction with a buy price, the seller provides bidders with an option to end the auction early by accepting a transaction at a posted price. The "Buy-It-Now" option on eBay is a leading example of an auction with a buy price. The study develops a model of an auction with a buy price in which bidders use the auction's reserve price and buy price to formulate a reference price. The model both explains why a revenue-maximizing seller would want to augment her auction with a buy price and demonstrates that the seller sets a higher reserve price when she can affect the bidders' reference price through the

  14. Auctioning Airport Slots?

    NASA Technical Reports Server (NTRS)

    Gruyer, Nicolas; Lenoir, Nathalie

    2003-01-01

    The current allocation of slots on congested European airports constitutes an obstacle to the effective liberalisation of air transportation undertaken in Europe. With a view to favouring effluent slot utilisation and competition, as is the goal of the Euopean commission, we propose to use a market mechanism, based on temporary" utilisation licences. In order to allocate those licences, we propose and describe an iterated combinatorial auction mechanism where a percentage of licences would be reallocated each season. A secondary market would also be set up in order to reallocate slots during a season. Since a combinatorial auction involve a complex optimisation procedure, we describe how it can be made to work in the case of auctions.

  15. Combinatorial Auctions without Money

    DTIC Science & Technology

    2014-05-01

    auctions. ICALP, pp. 90-101, 2010. [2] P. Briest, P. Krysta, and B. Vöcking. Approximation techniques for utilitarian mechanism design. STOC, pp. 39-48...Grandoni, P. Krysta, S. Leonardi, and C. Ventre. Utilitarian mechanism design for multi-objective optimization. SODA, pp. 573-584, 2010. [11] J. R

  16. Anonymous, Yet Trustworthy Auctions

    NASA Astrophysics Data System (ADS)

    Chanda, Prasit Bikash; Naessens, Vincent; de Decker, Bart

    An auction is an inevitable market mechanism to setup prices of goods or services in a competitive and dynamic environment. Anonymity of bidders is required to conceal their business strategies from competitors. However, it is also essential to provide the seller guarantees that a bidder is trustworthy and competent enough to perform certain tasks (e.g transports). This paper proposes an auction protocol where bidders will participate anonymously, yet prove to be trustworthy and competent and can be held accountable towards auctioneers and sellers. Moreover, the protocol introduces promises, bonuses and compensations to ensure the best price for the sellers, extra profit for bidders and opportunities for newcomers in the business. It also handles ties, and copes with last minute bidding. Finally, the auction’s fair proceedings and outcome can be verified by everyone.

  17. Innovations in Defense Acquisition Auctions: Lessons Learned and Alternative Mechanism Designs

    DTIC Science & Technology

    2008-02-21

    which contractor will ultimately produce the aircraft, with the winning contractor generally being the one capable of providing the greatest “ bang for...the buck”—“ bang ” being specifically measured by the weights placed on the various dimensions of quality. While there will typically be many different...guide. Retrieved June 1, 2007, from http://www.orbisonline.com/reverse_auction_guide8-29-02.pdf Gitelson, G., J. W. Bing and L. Laroche (2001, March

  18. Evaluation of PersianCAT Agent's Accepting Policy in Continuous Double Auction, Participant in CAT 2007 Competition

    NASA Astrophysics Data System (ADS)

    Honari, Sina; Fos-Hati, Amin; Ebadi, Mojtaba; Gomrokchi, Maziar

    As there is a growing tendency towards online auctions, online Multi Agent Systems for economic activities like stock exchanges is more in demand. CAT (CATallactics) competition has produced a great opportunity for researchers since 2007 to put their theories into practice in a real-time economic-based competition, combining traders and brokers. As one of participants, we evaluated our new accepting policy by putting it to challenge. In this paper we give a general overview of one of our policies in the market.

  19. ATHLETE : Double Auger Anchoring Mechanism

    NASA Technical Reports Server (NTRS)

    Shin, Joseph

    2011-01-01

    The All-Terrain Hex-Legged Extra-Terrestrial Explorer (ATHLETE) is a six-limbed robot designed to support surface explorations on Near Earth Objects, the Moon and Mars. ATHLETE can carry large payloads on its top deck and can carry a fully equipped pressurized habitat in low gravity. The robot has wheels on each of its six articulated limbs, allowing it to actively conform to terrain while driving and to walk when driving is impractical. With the use of a tool adapter, ATHLETE limbs can be equipped with end effectors to support various mission objectives. For work on Near Earth Objects and other microgravity environments, an anchoring mechanism is needed to keep the ATHLETE from floating off the surface. My goal for this spring session at JPL was to design and build a counter rotating, double auger, anchoring mechanism. The mechanism mates to the tool adapter and is driven off the wheel motor. The double auger anchoring mechanism will be tested in a regolith simulant that will determine the uplift capacity of the anchoring mechanism.

  20. ATHLETE : Double Auger Anchoring Mechanism

    NASA Technical Reports Server (NTRS)

    Shin, Joseph

    2011-01-01

    The All-Terrain Hex-Legged Extra-Terrestrial Explorer (ATHLETE) is a six-limbed robot designed to support surface explorations on Near Earth Objects, the Moon and Mars. ATHLETE can carry large payloads on its top deck and can carry a fully equipped pressurized habitat in low gravity. The robot has wheels on each of its six articulated limbs, allowing it to actively conform to terrain while driving and to walk when driving is impractical. With the use of a tool adapter, ATHLETE limbs can be equipped with end effectors to support various mission objectives. For work on Near Earth Objects and other microgravity environments, an anchoring mechanism is needed to keep the ATHLETE from floating off the surface. My goal for this spring session at JPL was to design and build a counter rotating, double auger, anchoring mechanism. The mechanism mates to the tool adapter and is driven off the wheel motor. The double auger anchoring mechanism will be tested in a regolith simulant that will determine the uplift capacity of the anchoring mechanism.

  1. Effects of Suboptimal Bidding in Combinatorial Auctions

    NASA Astrophysics Data System (ADS)

    Schneider, Stefan; Shabalin, Pasha; Bichler, Martin

    Though the VCG auction assumes a central place in the mechanism design literature, there are a number of reasons for favoring iterative combinatorial auction designs. Several promising ascending auction formats have been developed throughout the past few years based on primal-dual and subgradient algorithms and linear programming theory. Prices are interpreted as a feasible dual solution and the provisional allocation is interpreted as a feasible primal solution. iBundle( 3) (Parkes and Ungar 2000), dVSV (de Vries et al. 2007) and the Ascending Proxy auction (Ausubel and Milgrom 2002) result in VCG payoffs when the coalitional value function satisfies the buyer submodularity condition and bidders bid straightforward, which is an expost Nash equilibrium in that case. iBEA and CreditDebit auctions (Mishra and Parkes 2007) do not even require the buyer submodularity condition and achieve the same properties for general valuations. In many situations, however, one cannot assume bidders to bid straightforward and it is not clear from the theory how these non-linear personalized price auctions (NLPPAs) perform in this case. Robustness of auctions with respect to different bidding behavior is therefore a critical issue for any application. We have conducted a large number of computational experiments to analyze the performance of NLPPA designs with respect to different bidding strategies and different valuation models. We compare the results of NLPPAs to those of the VCG auction and those of iterative combinatorial auctions with approximate linear prices, such as ALPS (Bichler et al. 2009) and the Combinatorial Clock auction (Porter et al. 2003).

  2. Combinatorial auction design

    PubMed Central

    Porter, David; Rassenti, Stephen; Roopnarine, Anil; Smith, Vernon

    2003-01-01

    Combinatorial auctions allow for more expressive bidding in which participants can submit package bids with logical constraints that limit allowable outcomes. This type of auction can be useful when participants' values are complementary or when participants have production and financial constraints. However, combinatorial auctions are currently rare in practice. The main problems confronted in implementing these auctions are that they have computational uncertainty (i.e., there is no guarantee that the winning bids for such an auction can be found in a “reasonable” amount of time when the number of bidders and items becomes larger) and that the auction is cognitively complex and can lead participants to pursue perverse bidding strategies. This article describes a type of combinatorial auction that, during laboratory testing, eliminated these problems and produced extremely efficient outcomes. PMID:12893875

  3. Auction-based Security Game for Multiuser Cooperative Networks

    NASA Astrophysics Data System (ADS)

    Wang, An; Cai, Yueming; Yang, Wendong; Cheng, Yunpeng

    2013-04-01

    In this paper, we develop an auction-based algorithm to allocate the relay power efficiently to improve the system secrecy rate in a cooperative network, where several source-destination pairs and one cooperative relay are involved. On the one hand, the cooperative relay assists these pairs to transmit under a peak power constraint. On the other hand, the relay is untrusty and is also a passive eavesdropper. The whole auction process is completely distributed and no instantaneous channel state information exchange is needed. We also prove the existence and uniqueness of the Nash Equilibrium (NE) for the proposed power auction game. Moreover, the Pareto optimality is also validated. Simulation results show that our proposed auction-based algorithm can effectively improve the system secrecy rate. Besides, the proposed auction-based algorithm can converge to the unique NE point within a finite number of iterations. More interestingly, we also find that the proposed power auction mechanism is cheat-proof.

  4. Double-Swivel Mechanism For Reliable Release

    NASA Technical Reports Server (NTRS)

    King, Guy L.; Schneider, William C.

    1990-01-01

    Double-swivel toggle mechanism releases large, heavy objects reliably. Double-swiveling action of mechanism ensures it clears restraining pins upon release. Pins retain toggle and its load. If pin fails to withdraw at designated time for releasing payload, toggle swivels about its upper ball, and ring swivels about lower ball so ring flange clears failed pin. Double-swivel action ensures disengagement even it two pins fail to withdraw.

  5. An Auction-Based Spectrum Leasing Mechanism for Mobile Macro-Femtocell Networks of IoT

    PubMed Central

    Chen, Xin; Xing, Lei; Qiu, Tie; Li, Zhuo

    2017-01-01

    The Internet of Things (IoT) is a vision of the upcoming society. It can provide pervasive communication between two or more entities using 4G-LTE (Long Term Evolution) communication technology. In 4G-LTE networks, there are two important problems: helping manage the spectrum demands of IoT devices and achieving much more revenue with the limited resource. This paper proposes a pricing framework to investigate the spectrum leasing in mobile heterogeneous networks with single macrocell and multiple femtocells. We modeled the leasing procedure between the macrocell service provider (MSP) and femtocell holders (FHs) as an auction to motivate the MSP to lease its spectrum resource. All FHs act as the bidders, and the monopolist MSP acts as the auctioneer. In the auction, FHs submit their bids to rent the spectrum resource so that they can make a profit by selling it to their subscribers. The MSP determines the spectrum leasing amount and chooses the winning FHs by solving the dynamic programming-based 0–1 knapsack problem. In our proposed framework, we focus on the spectrum pricing strategy and revenue maximization of the MSP. The simulation results show that the proposed scheme provides effective motivation for the MSP to lease the spectrum to FHs, and both the MSP and FHs can benefit from spectrum leasing. PMID:28212317

  6. An Auction-Based Spectrum Leasing Mechanism for Mobile Macro-Femtocell Networks of IoT.

    PubMed

    Chen, Xin; Xing, Lei; Qiu, Tie; Li, Zhuo

    2017-02-16

    The Internet of Things (IoT) is a vision of the upcoming society. It can provide pervasive communication between two or more entities using 4G-LTE (Long Term Evolution) communication technology. In 4G-LTE networks, there are two important problems: helping manage the spectrum demands of IoT devices and achieving much more revenue with the limited resource. This paper proposes a pricing framework to investigate the spectrum leasing in mobile heterogeneous networks with single macrocell and multiple femtocells. We modeled the leasing procedure between the macrocell service provider (MSP) and femtocell holders (FHs) as an auction to motivate the MSP to lease its spectrum resource. All FHs act as the bidders, and the monopolist MSP acts as the auctioneer. In the auction, FHs submit their bids to rent the spectrum resource so that they can make a profit by selling it to their subscribers. The MSP determines the spectrum leasing amount and chooses the winning FHs by solving the dynamic programming-based 0-1 knapsack problem. In our proposed framework, we focus on the spectrum pricing strategy and revenue maximization of the MSP. The simulation results show that the proposed scheme provides effective motivation for the MSP to lease the spectrum to FHs, and both the MSP and FHs can benefit from spectrum leasing.

  7. Essays on wholesale auctions in deregulated electricity markets

    NASA Astrophysics Data System (ADS)

    Baltaduonis, Rimvydas

    2007-12-01

    The early experience in the restructured electric power markets raised several issues, including price spikes, inefficiency, security, and the overall relationship of market clearing prices to generation costs. Unsatisfactory outcomes in these markets are thought to have resulted in part from strategic generator behaviors encouraged by inappropriate market design features. In this dissertation, I examine the performance of three auction mechanisms for wholesale power markets - Offer Cost Minimization auction, Payment Cost Minimization auction and Simple-Offer auction - when electricity suppliers act strategically. A Payment Cost Minimization auction has been proposed as an alternative to the traditional Offer Cost Minimization auction with the intention to solve the problem of inflated wholesale electricity prices. Efficiency concerns for this proposal were voiced due to insights predicated on the assumption of true production cost revelation. Using a game theoretic approach and an experimental method, I compare the two auctions, strictly controlling for the level of unilateral market power. A specific feature of these complex-offer auctions is that the sellers submit not only the quantities and the minimum prices that they are willing to sell at, but also the start-up fees, which are designed to reimburse the fixed start-up costs of the generation plants. I find that the complex structure of the offers leaves considerable room for strategic behavior, which consequently leads to anti-competitive and inefficient market outcomes. In the last chapter of my dissertation, I use laboratory experiments to contrast the performance of two complex-offer auctions against the performance of a simple-offer auction, in which the sellers have to recover all their generation costs - fixed and variable - through a uniform market-clearing price. I find that a simple-offer auction significantly reduces consumer prices and lowers price volatility. It mitigates anti-competitive effects

  8. Earthquakes with non--double-couple mechanisms.

    PubMed

    Frohlich, C

    1994-05-06

    Seismological observations confirm that the pattern of seismic waves from some earthquakes cannot be produced by slip along a planar fault surface. More than one physical mechanism is required to explain the observed varieties of these non-double-couple earthquakes. The simplest explanation is that some earthquakes are complex, with stress released on two or more suitably oriented, nonparallel fault surfaces. However, some shallow earthquakes in volcanic and geothermal areas require other explanations. Current research focuses on whether fault complexity explains most observed non-double-couple earthquakes and to what extent ordinary earthquakes have non-double-couple components.

  9. Mechanical response of biopolymer double networks

    NASA Astrophysics Data System (ADS)

    Carroll, Joshua; Das, Moumita

    We investigate a double network model of articular cartilage (AC) and characterize its equilibrium mechanical response. AC has very few cells and the extracellular matrix mainly determines its mechanical response. This matrix can be thought of as a double polymer network made of collagen and aggrecan. The collagen fibers are stiff and resist tension and compression forces, while aggrecans are flexible and control swelling and hydration. We construct a microscopic model made of two interconnected disordered polymer networks, with fiber elasticity chosen to qualitatively mimic the experimental system. We study the collective mechanical response of this double network as a function of the concentration and stiffness of the individual components as well as the strength of the connection between them using rigidity percolation theory. Our results may provide a better understanding of mechanisms underlying the mechanical resilience of AC, and more broadly may also lead to new perspectives on the mechanical response of multicomponent soft materials. This work was partially supported by a Cottrell College Science Award.

  10. Bandwidth auction for SVC streaming in dynamic multi-overlay

    NASA Astrophysics Data System (ADS)

    Xiong, Yanting; Zou, Junni; Xiong, Hongkai

    2010-07-01

    In this paper, we study the optimal bandwidth allocation for scalable video coding (SVC) streaming in multiple overlays. We model the whole bandwidth request and distribution process as a set of decentralized auction games between the competing peers. For the upstream peer, a bandwidth allocation mechanism is introduced to maximize the aggregate revenue. For the downstream peer, a dynamic bidding strategy is proposed. It achieves maximum utility and efficient resource usage by collaborating with a content-aware layer dropping/adding strategy. Also, the convergence of the proposed auction games is theoretically proved. Experimental results show that the auction strategies can adapt to dynamic join of competing peers and video layers.

  11. A novel mechanism for creating double pulsars

    NASA Technical Reports Server (NTRS)

    Sigurdsson, Steinn; Hernquist, Lars

    1992-01-01

    Simulations of encounters between pairs of hard binaries, each containing a neutron star and a main-sequence star, reveal a new formation mechanism for double pulsars in dense cores of globular clusters. In many cases, the two normal stars are disrupted to form a common envelope around the pair of neutron stars, both of which will be spun up to become millisecond pulsars. We predict that a new class of pulsars, double millisecond pulsars, will be discovered in the cores of dense globular clusters. The genesis proceeds through a short-lived double-core common envelope phase, with the envelope ejected in a fast wind. It is possible that the progenitor may also undergo a double X-ray binary phase. Any circular, short-period double pulsar found in the galaxy would necessarily come from disrupted disk clusters, unlike Hulse-Taylor class pulsars or low-mass X-ray binaries which may be ejected from clusters or formed in the galaxy.

  12. A Study of Central Auction Based Wholesale Electricity Markets

    NASA Astrophysics Data System (ADS)

    Ceppi, Sofia; Gatti, Nicola

    The deregulation of electricity markets produced significant economic benefits, reducing prices to customers and opening several opportunities for new actors, e.g., new generators and distributors. A prominent scientific and technological challenge is the automation of such markets. In particular, we focus our attention on wholesale electricity markets based on a central auction. In these markets, generators sell electricity by means of a central auction to a public authority. Instead, the distribution of electricity to customers takes part in retail markets. The main works presented in the literature model wholesale markets as oligopolies, neglecting thus the specific auction mechanism. In this paper, we enrich these models by introducing an auction mechanism shaped on that used in the Italian wholesale electricity market, we solve the winner determination problem, and we preliminarily study the problem of searching for equilibria.

  13. Immune mechanism: a 'double-edged sword'.

    PubMed

    Musa, Mustaffa

    2013-05-01

    Immunology has now developed into an independent discipline in medicine which covers not only germ infection which is related to immunity solely but also covers a lot of non-infectious diseases such as autoimmune disease, allergies, and others. Therefore, "The Immune Mechanism: "A Double-Edged Sword" means that the immune mechanism (consisted of antibody mediated mechanism and T cell mediated mechanism), just like one edge playing the role of giving benefit (immunity) as it destroys the agent of infection, and another one can be detrimental as it will cause tissue/cell damages and then give rise to immune diseases (immunopathology). Now, the prevalence of these immune diseases is on the rise and has become a new challenge to our country towards developed country in 2020. Therefore, we have to make ample preparation (laboratory facilities/services, main power, and research) from now on in order to face the problems and challenges.

  14. Cryptanalysis and melioration of secure quantum sealed-bid auction with post-confirmation

    NASA Astrophysics Data System (ADS)

    He, Li-Bao; Huang, Liu-Sheng; Yang, Wei; Xu, Rui; Han, Dian-Qi

    2012-12-01

    We investigate the quantum sealed-bid auction protocol proposed by Zhao et al. (Opt Commun 283:1394, 2010). It uses M groups n-particle GHZ states to represent bids and a post-confirmation mechanism to guarantee the honesty of the quantum sealed-bid auction. However, in our opinion the protocol still does not complete the task of a sealed-bid auction fairly. It is shown that a large group of dishonest bidders can collude to obtain all the other one's secret bids before the opening phase of the auction with a probability polynomially close to one. Moreover, a simple feasible improvement of the protocol is proposed.

  15. The Double Cone: A Mechanical Paradox or a Geometrical Constraint?

    ERIC Educational Resources Information Center

    Gallitto, Aurelio Agliolo; Fiordilino, Emilio

    2011-01-01

    In the framework of the Italian National Plan "Lauree Scientifiche" (PLS) in collaboration with secondary schools, we have investigated the mechanical paradox of the double cone. We have calculated the geometric condition for obtaining an upward movement. Based on this result, we have built a mechanical model with a double cone made of aluminum…

  16. The Double Cone: A Mechanical Paradox or a Geometrical Constraint?

    ERIC Educational Resources Information Center

    Gallitto, Aurelio Agliolo; Fiordilino, Emilio

    2011-01-01

    In the framework of the Italian National Plan "Lauree Scientifiche" (PLS) in collaboration with secondary schools, we have investigated the mechanical paradox of the double cone. We have calculated the geometric condition for obtaining an upward movement. Based on this result, we have built a mechanical model with a double cone made of aluminum…

  17. Internet Auction Sellers: Does Size Really Matter?

    ERIC Educational Resources Information Center

    Halstead, Diane; Becherer, Richard C.

    2003-01-01

    Examines the Internet auction phenomenon as it relates to the marketing mix of online auction sellers. The data indicate that, while there is great diversity among businesses that utilize online auctions, distinct cost leadership and differentiation marketing strategies are both evident. These two approaches are further distinguished in terms of…

  18. Internet Auction Sellers: Does Size Really Matter?

    ERIC Educational Resources Information Center

    Halstead, Diane; Becherer, Richard C.

    2003-01-01

    Examines the Internet auction phenomenon as it relates to the marketing mix of online auction sellers. The data indicate that, while there is great diversity among businesses that utilize online auctions, distinct cost leadership and differentiation marketing strategies are both evident. These two approaches are further distinguished in terms of…

  19. China's Land Market Auctions: Evidence of Corruption?

    PubMed

    Cai, Hongbin; Henderson, J Vernon; Zhang, Qinghua

    2013-01-01

    This paper studies the urban land market in China in 2003-2007. In China, all urban land is owned by the state. Leasehold use rights for land for (re)development are sold by city governments and are a key source of city revenue. Leasehold sales are viewed as a major venue for corruption, prompting a number of reforms over the years. Reforms now require all leasehold rights be sold at public auction. There are two main types of auction: regular English auction and an unusual type which we call a "two stage auction". The latter type of auction seems more subject to corruption, and to side deals between potential bidders and the auctioneer. Absent corruption, theory suggests that two stage auctions would most likely maximize sales revenue for properties which are likely to have relatively few bidders, or are "cold", which would suggest negative selection on property unobservables into such auctions. However, if such auctions are more corruptible, that could involve positive selection as city officials divert hotter properties to a more corruptible auction form. The paper finds that, overall, sales prices are lower for two stage auctions, and there is strong evidence of positive selection. The price difference is explained primarily by the fact that two stage auctions typically have just one bidder, or no competition despite the vibrant land market in Chinese cities.

  20. Exploring Online Auction Behaviors and Motivations

    ERIC Educational Resources Information Center

    Jeon, Sua; Crutsinger, Christy; Kim, Haejung

    2008-01-01

    The availability and convenience of the Internet, combined with the variety of products available at any given time, have contributed to the success of online auctions.This exploratory study examined online auction behaviors among college students in an attempt to identify underlying dimensions of auction motivations. Questionnaires completed by…

  1. Exploring Online Auction Behaviors and Motivations

    ERIC Educational Resources Information Center

    Jeon, Sua; Crutsinger, Christy; Kim, Haejung

    2008-01-01

    The availability and convenience of the Internet, combined with the variety of products available at any given time, have contributed to the success of online auctions.This exploratory study examined online auction behaviors among college students in an attempt to identify underlying dimensions of auction motivations. Questionnaires completed by…

  2. 40 CFR 73.70 - Auctions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.70 Auctions... years after purchase. *These are unsold advance allowances from the direct sale program for 1993, 1994... Auction Subaccount, including unsold allowances transferred from the preceding year's direct sale, and...

  3. 7 CFR 1955.148 - Auction sales.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Auction sales. 1955.148 Section 1955.148 Agriculture... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.148 Auction sales. This section provides guidance on the sale of all inventory property by auction, except FSA...

  4. 7 CFR 46.25 - Auction sales.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Auction sales. 46.25 Section 46.25 Agriculture... THAN RULES OF PRACTICE) UNDER THE PERISHABLE AGRICULTURAL COMMODITIES ACT, 1930 Auction Sales § 46.25 Auction sales. Commission merchants, dealers and brokers who offer produce for sale through...

  5. Molecular mechanism of double Holliday junction dissolution

    PubMed Central

    2014-01-01

    Processing of homologous recombination intermediates is tightly coordinated to ensure that chromosomal integrity is maintained and tumorigenesis avoided. Decatenation of double Holliday junctions, for example, is catalysed by two enzymes that work in tight coordination and belong to the same ‘dissolvasome’ complex. Within the dissolvasome, the RecQ-like BLM helicase provides the translocase function for Holliday junction migration, while the topoisomerase III alpha-RMI1 subcomplex works as a proficient DNA decatenase, together resulting in double-Holliday-junction unlinking. Here, we review the available architectural and biochemical knowledge on the dissolvasome machinery, with a focus on the structural interplay between its components. PMID:25061510

  6. Statistical Properties of Online Auctions

    NASA Astrophysics Data System (ADS)

    Namazi, Alireza; Schadschneider, Andreas

    We characterize the statistical properties of a large number of online auctions run on eBay. Both stationary and dynamic properties, like distributions of prices, number of bids etc., as well as relations between these quantities are studied. The analysis of the data reveals surprisingly simple distributions and relations, typically of power-law form. Based on these findings we introduce a simple method to identify suspicious auctions that could be influenced by a form of fraud known as shill bidding. Furthermore the influence of bidding strategies is discussed. The results indicate that the observed behavior is related to a mixture of agents using a variety of strategies.

  7. Mechanical seal having a double-tier mating ring

    DOEpatents

    Khonsari, Michael M.; Somanchi, Anoop K.

    2005-09-13

    An apparatus and method to enhance the overall performance of mechanical seals in one of the following ways: by reducing seal face wear, by reducing the contact surface temperature, or by increasing the life span of mechanical seals. The apparatus is a mechanical seal (e.g., single mechanical seals, double mechanical seals, tandem mechanical seals, bellows, pusher mechanical seals, and all types of rotating and reciprocating machines) comprising a rotating ring and a double-tier mating ring. In a preferred embodiment, the double-tier mating ring comprises a first and a second stationary ring that together form an agitation-inducing, guided flow channel to allow for the removal of heat generated at the seal face of the mating ring by channeling a coolant entering the mating ring to a position adjacent to and in close proximity with the interior surface area of the seal face of the mating ring.

  8. Mechanically tough, elastic and stable rope-like double nanohelices.

    PubMed

    Dai, L; Huang, X J; Dong, L X; Zhang, Q; Zhang, L

    2014-08-21

    Double helix nanostructures have been the object of intense theoretical and experimental investigations in recent years due to their various types of available materials and unique morphology. Among these structures, rope-like double nanohelices of two strands in contact along a line can be obtained using any one-dimensional nanostructure. In this work, we establish a novel theory for quantitatively exploring the statics and dynamics of rope-like double nanohelices by employing the concept of the extensible Cosserat curve. The rope-like double nanohelices are tough, relatively elastic, and mechanically stable, which agrees well with the experiments. The characteristics of the interaction between the two strands, the tensile modulus and the torque are precisely described and explained across the entire stretching region. The proposed model offers in depth quantitative insight into the mechanics of double helix nanostructures, and supplies a reliable reference for further experimental research.

  9. Multiparty quantum sealed-bid auction using single photons as message carrier

    NASA Astrophysics Data System (ADS)

    Liu, Wen-Jie; Wang, Hai-Bin; Yuan, Gong-Lin; Xu, Yong; Chen, Zhen-Yu; An, Xing-Xing; Ji, Fu-Gao; Gnitou, Gnim Tchalim

    2016-02-01

    In this study, a novel multiparty quantum sealed-bid auction protocol using the single photons as the message carrier of bids is proposed, followed by an example of three-party auction. Compared with those protocols based on the entangled states (GHZ state, EPR pairs, etc.), the present protocol is more economic and feasible within present technology. In order to guarantee the security and the fairness of the auction, the decoy photon checking technique and an improved post-confirmation mechanism with EPR pairs are introduced, respectively.

  10. Auctions with Dynamic Populations: Efficiency and Revenue Maximization

    NASA Astrophysics Data System (ADS)

    Said, Maher

    We study a stochastic sequential allocation problem with a dynamic population of privately-informed buyers. We characterize the set of efficient allocation rules and show that a dynamic VCG mechanism is both efficient and periodic ex post incentive compatible; we also show that the revenue-maximizing direct mechanism is a pivot mechanism with a reserve price. We then consider sequential ascending auctions in this setting, both with and without a reserve price. We construct equilibrium bidding strategies in this indirect mechanism where bidders reveal their private information in every period, yielding the same outcomes as the direct mechanisms. Thus, the sequential ascending auction is a natural institution for achieving either efficient or optimal outcomes.

  11. Auctions for coastal energy resources

    NASA Astrophysics Data System (ADS)

    Griffin, Robert M.

    It is becoming increasingly common to allocate public resources to the private sector for the purpose of developing these resources. One of the earliest uses of auctions in the U.S. for allocating rights to public resources was in the offshore oil and gas industry. The U.S. Federal government, through the Department of Interior (DOI), has used auctions to allocate development rights to offshore oil and gas resources to the private sector since the 1950's. Since then many things have changed. Oil and gas markets have gone through boom and bust cycles, giant technological advances in extraction and assessment have taken place, and alternative energy based in the coastal zone is now in demand in markets as well. There has been an enormous amount of research into the drivers of bidder behavior in auctions and optimal auction design in the last 60 years as well. Throughout all of this, the DOI has continued to use basically the same exact auction design to allocate oil and gas leases. The U.S. offshore oil and gas resources sold by the Department of Interior have accounted for more than $65 billion in revenue since the program started. These offshore resources are an important source of government revenue and national wealth. Additionally, the expansion of the energy sector offshore has enormous potential for electricity generation in the U.S., estimated by the National Renewable Energy Laboratory as approaching 54 gigawatts by 2030 (U.S. Department of Energy, 2008). Taken together, the DOI controls access to a large part of the future of energy in the U.S. The research herein assesses the auction formats used to allocate both fossil fuels and renewable resources on the Outer Continental Shelf (OCS). The first manuscript looks at the current method used by the DOI to allocate oil and gas leases on the OCS, and is primarily interested in how bidders behave in this environment. Using latent class estimation techniques to separate distinct bidding behavior in a laboratory

  12. A Theory of Auctions and Competitive Bidding.

    DTIC Science & Technology

    1981-12-01

    seventh century A.D.2/ In the United States in the 1980’ s , auctions account for an enormous volume of economic activity. Every week, the U.S. Treasury...auction - S games must coincide. Initially, this strategic equivalence of the two auction forms may seem puzzling. It might appear that after a bidder...to the bidder depends only on the rules of the auction and the strategies of the others, and not on his private valuation of the * object. ’ S Figure

  13. Toughening Mechanism of Double Network Hydrogels

    NASA Astrophysics Data System (ADS)

    Gong, Jian Ping

    2010-03-01

    The fundamental toughening mechanism of DN gels [1] is of great interest to researchers. Extensive experimental and theoretical studies have been performed to explain this mechanism [2-7]. Yielding and necking deformation [2] that was observed through tensile tests and rate-independent hysteresis [3] observed through cyclic loading tests have indicated that DN gels can accumulate internal damage before the suffering macroscopic fracture; after damage accumulation, the DN gels become much softer. We assume that on the microscopic level, yielding is caused by the partial breakage and fragmentation of the brittle first network and interconnection among the fragments by the polymer chains of second network [2]. Brown [4] and Tanaka [5] have proposed similar models that can qualitatively explain the anomalously high fracture energy, assuming that the DN gel is locally damaged (yielded) around the crack tip and that the energy dissipated for damage accumulation enhances the effective fracture energy. Using AFM measurements [6] and 3D color laser microscope[7], we successfully detected the existence of softened regions, of several hundreds μm in thickness, at the crack tip just below the fracture surfaces, which supports the assumption of localized damage accumulation. A linear relationship between the thickness of the softened yielding zone and the fracture energy of the gel was observed, which is in agreement with the local yielding zone explanation. [4pt] [1] Gong, J. P.; Katsuyama, Y.; Kurokawa, T.; Osada, Y. Adv. Mater. 2003, 15, 1155. [0pt] [2] Na Y.H., Tanaka Y., Kawauchi Y., Furukawa H., Sumiyoshi T., Gong J. P., Osada Y., Macromolecules 2006, 39(14), 4641. [0pt] [3] Webber, R. E.; Creton, C.; Brown, H. R.; Gong, J. P. Macromolecules 2007, 40, 2919. [0pt] [4] Brown, H. R. Macromolecules 2007, 40, 3815. [0pt] [5] Tanaka, Y. Euro Phys. Letter. 2007, 78, 56005. [0pt] [6] Tanaka Y.; Kawauchi Y.; Kurokawa T.; Furukawa H.; Okajima T.; Gong J. P. Macrom. Rapid Comm

  14. 40 CFR 73.70 - Auctions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.70 Auctions.... Sales of offered allowances, including, but not limited to, allowances offered by more than one offeror... Administrator will transfer to the Allowance Tracking System account of each source that includes a unit...

  15. 7 CFR 29.36 - Auction market.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Auction market. 29.36 Section 29.36 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.36 Auction market. A place to which tobacco is delivered by the...

  16. 7 CFR 29.36 - Auction market.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Auction market. 29.36 Section 29.36 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.36 Auction market. A place to which tobacco is delivered by the...

  17. 19 CFR 127.34 - Auctioneer's commissions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Auctioneer's commissions. 127.34 Section 127.34 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY GENERAL ORDER, UNCLAIMED, AND ABANDONED MERCHANDISE Proceeds of Sale § 127.34 Auctioneer's...

  18. 19 CFR 127.34 - Auctioneer's commissions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Auctioneer's commissions. 127.34 Section 127.34 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY GENERAL ORDER, UNCLAIMED, AND ABANDONED MERCHANDISE Proceeds of Sale § 127.34 Auctioneer's...

  19. 7 CFR 1955.131 - Auctioneers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property Use of Contractors to Dispose of Inventory Property § 1955.131 Auctioneers. The services of licensed auctioneers, if required, may be used to...

  20. 7 CFR 29.36 - Auction market.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Auction market. 29.36 Section 29.36 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.36 Auction market. A place to which tobacco is delivered by...

  1. 7 CFR 29.36 - Auction market.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Auction market. 29.36 Section 29.36 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.36 Auction market. A place to which tobacco is delivered by...

  2. 7 CFR 29.36 - Auction market.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Auction market. 29.36 Section 29.36 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.36 Auction market. A place to which tobacco is delivered by...

  3. Collusion in Auctions for Emission Permits: An Experimental Analysis

    ERIC Educational Resources Information Center

    Burtraw, Dallas; Goeree, Jacob; Holt, Charles A.; Myers, Erica; Palmer, Karen; Shobe, William

    2009-01-01

    Environmental markets have several institutional features that provide a new context for the use of auctions and that have not been studied previously. This paper reports on laboratory experiments testing three auction forms--uniform and discriminatory price sealed-bid auctions and an ascending clock auction. We test the ability of subjects to…

  4. 29 CFR 780.617 - Adjunct livestock auction operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Adjunct livestock auction operations. 780.617 Section 780... Employment in Agriculture and Livestock Auction Operations Under the Section 13(b)(13) Exemption Requirements for Exemption § 780.617 Adjunct livestock auction operations. The livestock auction...

  5. 77 FR 57085 - Mobility Fund Phase I Auction; Release of Files with Recalculated Road Miles for Auction 901...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... COMMISSION Mobility Fund Phase I Auction; Release of Files with Recalculated Road Miles for Auction 901; Mock... updated data files of census blocks eligible for the Mobility Fund Phase I support to be offered in Auction 901, which is to be held on September 27, 2012, and the change of the mock auction date from...

  6. Auction-based resource allocation game under a hierarchical structure

    NASA Astrophysics Data System (ADS)

    Cui, Yingying; Zou, Suli; Ma, Zhongjing

    2016-01-01

    This paper studies a class of auction-based resource allocation games under a hierarchical structure, such that each supplier is assigned a certain amount of resource from a single provider and allocates it to its buyers with auction mechanisms. To implement the efficient allocations for the underlying hierarchical system, we first design an auction mechanism, for each local system composed of a supplier and its buyers, which inherits the advantages of the progressive second price mechanism. By employing a dynamic algorithm, each local system converges to its own efficient Nash equilibrium, at which the efficient resource allocation is achieved and the bidding prices of all the buyers in this local system are identical with each other. After the local systems reach their own equilibria respectively, the resources assigned to suppliers are readjusted via a dynamic hierarchical algorithm with respect to the bidding prices associated with the implemented equilibria of local systems. By applying the proposed hierarchical process, the formulated hierarchical system can converge to the efficient allocation under certain mild conditions. The developed results in this work are demonstrated with simulations.

  7. Sequential Auctions in Uncertain Information Settings

    NASA Astrophysics Data System (ADS)

    Fatima, Shaheen; Wooldridge, Michael; Jennings, Nicholas R.

    This paper analyzes sequential auctions for private value objects using second-price sealed-bid rules. Now, the equilibrium bids for such auctions depend on the information uncertainty of the bidders. Specifically, there are three key auction parameters that the bidders could be uncertain about: the valuations of the objects for sale, the number of objects for sale, and the number of participating bidders. We analyse the bidding behaviour for each of these three sources of uncertainty. For each setting, we first find the equilibrium bidding strategies for the individual auctions that comprise a series. Then we analyze the effect of these uncertainties on the computational and economic properties of the equilibrium solution. The former analysis is essential if we want to use software agents to bid on our behalf. The latter is essential because both the auctioneer and the bidders want to know how these uncertainties affect their profits. Thus we compare the outcomes for these settings from the perspective of the bidders (i.e., in terms of their profits), from the perspective of the auctioneer (i.e., in terms of his revenue), and from a global perspective (i.e., in terms of auction efficiency).

  8. Electrical power generation by mechanically modulating electrical double layers.

    PubMed

    Moon, Jong Kyun; Jeong, Jaeki; Lee, Dongyun; Pak, Hyuk Kyu

    2013-01-01

    Since Michael Faraday and Joseph Henry made their great discovery of electromagnetic induction, there have been continuous developments in electrical power generation. Most people today get electricity from thermal, hydroelectric, or nuclear power generation systems, which use this electromagnetic induction phenomenon. Here we propose a new method for electrical power generation, without using electromagnetic induction, by mechanically modulating the electrical double layers at the interfacial areas of a water bridge between two conducting plates. We find that when the height of the water bridge is mechanically modulated, the electrical double layer capacitors formed on the two interfacial areas are continuously charged and discharged at different phases from each other, thus generating an AC electric current across the plates. We use a resistor-capacitor circuit model to explain the results of this experiment. This observation could be useful for constructing a micro-fluidic power generation system in the near future.

  9. Quantum auctions: Facts and myths

    NASA Astrophysics Data System (ADS)

    Piotrowski, Edward W.; Sładkowski, Jan

    2008-06-01

    Quantum game theory, whatever opinions may be held due to its abstract physical formalism, have already found various applications even outside the orthodox physics domain. In this paper we introduce the concept of a quantum auction, its advantages and drawbacks. Then we describe the models that have already been put forward. A general model involves Wigner formalism and infinite dimensional Hilbert spaces - we envisage that the implementation might not be an easy task. But a restricted model advocated by the Hewlett-Packard group (Hogg et al.) seems to be much easier to implement. We focus on problems related to combinatorial auctions and technical assumptions that are made. Powerful quantum algorithms for finding solutions would extend the range of possible applications. Quantum strategies, being qubits, can be teleported but are immune from cloning - therefore extreme privacy of the agent’s activity could in principle be guaranteed. Then we point out some key problems that have to be solved before commercial use would be possible. With present technology, optical networks, single photon sources and detectors seems to be sufficient for an experimental realization in the near future.

  10. Auction-based distributed efficient economic operations of microgrid systems

    NASA Astrophysics Data System (ADS)

    Zou, Suli; Ma, Zhongjing; Liu, Xiangdong

    2014-12-01

    This paper studies the economic operations of the microgrid in a distributed way such that the operational schedule of each of the units, like generators, load units, storage units, etc., in a microgrid system, is implemented by autonomous agents. We apply and generalise the progressive second price (PSP) auction mechanism which was proposed by Lazar and Semret to efficiently allocate the divisible network resources. Considering the economic operation for the microgrid systems, the generators play as sellers to supply energy and the load units play as the buyers to consume energy, while a storage unit, like battery, super capacitor, etc., may transit between buyer and seller, such that it is a buyer when it charges and becomes a seller when it discharges. Furthermore in a connected mode, each individual unit competes against not only the other individual units in the microgrid but also the exogenous main grid possessing fixed electricity price and infinite trade capacity; that is to say, the auctioneer assigns the electricity among all individual units and the main grid with respect to the submitted bid strategies of all individual units in the microgrid in an economic way. Due to these distinct characteristics, the underlying auction games are distinct from those studied in the literature. We show that under mild conditions, the efficient economic operation strategy is a Nash equilibrium (NE) for the PSP auction games, and propose a distributed algorithm under which the system can converge to an NE. We also show that the performance of worst NE can be bounded with respect to the system parameters, say the energy trading price with the main grid, and based upon that, the implemented NE is unique and efficient under some conditions.

  11. Waveguide formation mechanism generated by double doping in ferroelectric crystals

    NASA Astrophysics Data System (ADS)

    Atuchin, V. V.; Ziling, C. C.; Savatinova, I.; Armenise, M. N.; Passaro, V. M. N.

    1995-12-01

    Physical mechanisms causing the refractive index increase Δn in uniaxial oxidized ferroelectric crystals subjected to double doping are discussed. The analysis shows that the index changes of the two different dopants, ΔnA and ΔnB, are additive only if the corresponding changes of the spontaneous polarization are small. Ti indiffusion and proton exchange (TIPE) waveguides in LiNbO3 are considered as an example of the case when this condition is not fulfilled. The hydrogen-lithium substitution in such waveguides leads to a strong reduction of the spontaneous polarization of the virgin crystals and the final index change Δn is not a sum of ΔnA and ΔnB. A physical model is developed to explain light waveguiding in double-doped ferroelectric structures. Experimental data obtained for TIPE waveguides confirm the model.

  12. Sold!: Auction Methods for Multirobot Coordination

    DTIC Science & Technology

    2002-10-01

    758 IEEE TRANSACTIONS ON ROBOTICS AND AUTOMATION, VOL. 18, NO. 5, OCTOBER 2002 Sold!: Auction Methods for Multirobot Coordination Brian P. Gerkey and...Auctions have been 760 IEEE TRANSACTIONS ON ROBOTICS AND AUTOMATION, VOL. 18, NO. 5, OCTOBER 2002 demonstrated in the control of simulated robots...different robots execute the same task using different resources. 762 IEEE TRANSACTIONS ON ROBOTICS AND AUTOMATION, VOL. 18, NO. 5, OCTOBER 2002 is

  13. 40 CFR 73.73 - Delegation of auctions and sales and termination of auctions and sales.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.73 Delegation of auctions and sales and termination of... consecutive calendar years, fewer than 20 percent of the allowances available in the subaccount for...

  14. 76 FR 81932 - Auction of FM Broadcast Construction Permits; Revised Construction Permit Number in Auction 93

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... FURTHER INFORMATION CONTACT: Linda Sanderson, Wireless Telecommunications Bureau, Auctions and Spectrum...://wireless.fcc.gov/auctions/93/ , or by using the search function for AU Docket No. 11-146 on the Commission... Wireless Telecommunications and Media Bureaus announce a change to the construction permit number for...

  15. Double-exchange mechanism in rare-earth compounds

    SciTech Connect

    Gulacsi, M.

    2015-03-15

    We show that double-exchange mechanism is responsible for ferromagnetism in low dimensional rare-earth compounds. We use the bosonized version of the one-dimensional Anderson lattice model in Toulouse limit to characterize the properties of the emerging ferromagnetic phase. We give a comprehensive description of the ferromagnetic ordering of the correlated electrons which appears at intermediate couplings and doping. The obtained ferromagnetic phase transitions have been identified to be an order–disorder transition of the quantum random transverse-field Ising type.

  16. Design Implications of Real-Time Feedback in Continuous Combinatorial Auctions: An Experimental Investigation

    ERIC Educational Resources Information Center

    Sanyal, Pallab

    2009-01-01

    Information Technology (IT) has spawned the growth of novel and innovative market mechanisms (such as online auctions) and associated businesses (such as eBay and Priceline) that were not feasible without the capabilities and reach of these modern information technologies. Previous studies on designing trading mechanisms for online markets…

  17. Design Implications of Real-Time Feedback in Continuous Combinatorial Auctions: An Experimental Investigation

    ERIC Educational Resources Information Center

    Sanyal, Pallab

    2009-01-01

    Information Technology (IT) has spawned the growth of novel and innovative market mechanisms (such as online auctions) and associated businesses (such as eBay and Priceline) that were not feasible without the capabilities and reach of these modern information technologies. Previous studies on designing trading mechanisms for online markets…

  18. A Bayesian formulation for auction-based task allocation in heterogeneous multi-agent teams

    NASA Astrophysics Data System (ADS)

    Pippin, Charles E.; Christensen, Henrik

    2011-06-01

    In distributed, heterogeneous, multi-agent teams, agents may have different capabilities and types of sensors. Agents in dynamic environments will need to cooperate in real-time to perform tasks with minimal costs. Some example scenarios include dynamic allocation of UAV and UGV robot teams to possible hurricane survivor locations, search and rescue and target detection. Auction based algorithms scale well because agents generally only need to communicate bid information. In addition, the agents are able to perform their computations in parallel and can operate on local information. Furthermore, it is easy to integrate humans and other vehicle types and sensor combinations into an auction framework. However, standard auction mechanisms do not explicitly consider sensors with varying reliability. The agents sensor qualities should be explicitly accounted. Consider a scenario with multiple agents, each carrying a single sensor. The tasks in this case are to simply visit a location and detect a target. The sensors are of varying quality, with some having a higher probability of target detection. The agents themselves may have different capabilities, as well. The agents use knowledge of their environment to submit cost-based bids for performing each task and an auction is used to perform the task allocation. This paper discusses techniques for including a Bayesian formulation of target detection likelihood into this auction based framework for performing task allocation across multi-agent heterogeneous teams. Analysis and results of experiments with multiple air systems performing distributed target detection are also included.

  19. Electrical Power Generation by Mechanically Modulating Electrical Double Layers

    NASA Astrophysics Data System (ADS)

    Pak, Hyuk Kyu; Moon, Jong Kyun

    2014-11-01

    Since Michael Faraday and Joseph Henry made their great discovery of electromagnetic induction, there have been continuous developments in electrical power generation. Most people today get electricity from thermal, hydroelectric, or nuclear power generation systems, which use this electromagnetic induction phenomenon. Here we propose a new method for electrical power generation, without using electromagnetic induction, by mechanically modulating the electrical double layers at the interfacial areas of a water bridge between two conducting plates. We find that when the height of the water bridge is mechanically modulated, the electrical double layer capacitors formed on the two interfacial areas are continuously charged and discharged at different phases from each other, thus generating an AC electric current across the plates. We use a resistor-capacitor circuit model to explain the results of this experiment. This observation could be useful for constructing a micro-fluidic power generation system and for understanding the interfacial charge distribution in solid-liquid interfaces in the near future. This work was supported by Center for Soft and Living Matter through IBS prgram in Korea.

  20. Auctionable fixed transmission rights for congestion management

    NASA Astrophysics Data System (ADS)

    Alomoush, Muwaffaq Irsheid

    the transaction by the ISO, take a decision to expand the existing system, or retain the original structure of the system. Also, the thesis investigates the impact of wheeling transactions on congestion management, where we present a generalized mathematical model for the Fixed Transmission Right (FTR) auction. The auction guarantees FTR availability to all participants on a non-discriminatory basis, in which system users are permitted to buy, sell and trade FTRs through an auction. When FTRs are utilized with LMPs, they increase the efficient use of the transmission system and let a transmission customer gain advantageous features such as acquiring a mechanism to offset the extra cost due to congestion charges, providing financial and operational certainty and making system users pay for the actual use of the congested paths. The thesis also highlighted FTR trading in secondary markets to self-arrange access across different paths, create long-term transmission rights and provide more commercial certainty.

  1. Prior-Free Multi-Unit Auctions with Ordered Bidders

    DTIC Science & Technology

    2014-05-01

    case, the Bayesian optimal auction awards items to the (at most k) bidders with the highest positive virtual valuations. The payment of a winning...Prior-Free Multi-Unit Auctions with Ordered Bidders∗ Sayan Bhattacharya† Elias Koutsoupias‡ Janardhan Kulkarni§ Stefano Leonardi¶ Tim Roughgarden...Xiaoming Xu∗∗ Abstract Prior-free auctions are robust auctions that assume no distribution over bidders’ valuations and provide worst-case (input-by

  2. The value of victory: social origins of the winner's curse in common value auctions

    PubMed Central

    van den Bos, Wouter; Li, Jian; Lau, Tatiana; Maskin, Eric; Cohen, Jonathan D.; Montague, P. Read; McClure, Samuel M.

    2009-01-01

    Auctions, normally considered as devices facilitating trade, also provide a way to probe mechanisms governing one's valuation of some good or action. One of the most intriguing phenomena in auction behavior is the winner's curse — the strong tendency of participants to bid more than rational agent theory prescribes, often at a significant loss. The prevailing explanation suggests that humans have limited cognitive abilities that make estimating the correct bid difficult, if not impossible. Using a series of auction structures, we found that bidding approaches rational agent predictions when participants compete against a computer. However, the winner's curse appears when participants compete against other humans, even when cognitive demands for the correct bidding strategy are removed. These results suggest the humans assign significant future value to victories over human but not over computer opponents even though such victories may incur immediate losses, and that this valuation anomaly is the origin of apparently irrational behavior. PMID:20305741

  3. Control mechanism of double-rotator-structure ternary optical computer

    NASA Astrophysics Data System (ADS)

    Kai, SONG; Liping, YAN

    2017-03-01

    Double-rotator-structure ternary optical processor (DRSTOP) has two characteristics, namely, giant data-bits parallel computing and reconfigurable processor, which can handle thousands of data bits in parallel, and can run much faster than computers and other optical computer systems so far. In order to put DRSTOP into practical application, this paper established a series of methods, namely, task classification method, data-bits allocation method, control information generation method, control information formatting and sending method, and decoded results obtaining method and so on. These methods form the control mechanism of DRSTOP. This control mechanism makes DRSTOP become an automated computing platform. Compared with the traditional calculation tools, DRSTOP computing platform can ease the contradiction between high energy consumption and big data computing due to greatly reducing the cost of communications and I/O. Finally, the paper designed a set of experiments for DRSTOP control mechanism to verify its feasibility and correctness. Experimental results showed that the control mechanism is correct, feasible and efficient.

  4. A mechanism that triggers double arcing during plasma arc cutting

    NASA Astrophysics Data System (ADS)

    Nemchinsky, Valerian

    2009-10-01

    Double arcing (DA) is a phenomenon when a transferred arc, flowing inside an electrically insulated nozzle, breaks into two separate arcs: one that connects the cathode and the nozzle and another that connects the nozzle and a work-piece. It is a commonly accepted opinion that the reason for DA is high voltage drop in the plasma inside the nozzle. However, the specific mechanism that triggers the DA development is not clear. In this paper, we propose such a mechanism. Dielectric films deposited inside the nozzle's orifice play the key role in this mechanism. These films are charged by ion current from plasma. A strong electric field is created inside the film and at the boundary of the film and clean metal of the nozzle. This gives rise to a thermo-field electron emission from the clean metal that borders the film. Emitted electrons are accelerated at the voltage drop between the nozzle and plasma. These electrons produce extra ions, which in turn move back to the film and additionally charge it. This sequence of events leads to explosive instability if the voltage drop inside the nozzle is high enough. Experiments to check the proposed mechanism are suggested.

  5. Bidding Agents That Perpetrate Auction Fraud

    NASA Astrophysics Data System (ADS)

    Trevathan, Jarrod; McCabe, Alan; Read, Wayne

    This paper presents a software bidding agent that inserts fake bids on the seller's behalf to inflate an auction's price. This behaviour is referred to as shill bidding. Shill bidding is strictly prohibited by online auctioneers, as it defrauds unsuspecting buyers by forcing them to pay more for the item. The malicious bidding agent was constructed to aid in developing shill detection techniques. We have previously documented a simple shill bidding agent that incrementally increases the auction price until it reaches the desired profit target, or it becomes too risky to continue bidding. This paper presents an adaptive shill bidding agent which when used over a series of auctions with substitutable items, can revise its strategy based on bidding behaviour in past auctions. The adaptive agent applies a novel prediction technique referred to as the Extremum Consistency (EC) algorithm, to determine the optimal price to aspire for. The EC algorithm has successfully been used in handwritten signature verification for determining the maximum and minimum values in an input stream. The agent's ability to inflate the price has been tested in a simulated marketplace and experimental results are presented.

  6. Shock interaction mechanisms on a double wedge at Mach 7

    NASA Astrophysics Data System (ADS)

    Durna, Ahmet Selim; El Hajj Ali Barada, Mohamad; Celik, Bayram

    2016-09-01

    Present computational study investigates formation and interaction mechanisms of shocks and boundary layer for low enthalpy Mach 7 flows of nitrogen over double wedges, which have fixed fore and various aft angles of 30° and 45°-60°, respectively. We use a density based finite-volume Navier-Stokes solver to simulate low enthalpy Mach 7 flows of nitrogen over double wedges. The solver is first and second order accurate in time and space, respectively. The meshes used in simulations of two-dimensional laminar flows consist of multiple blocks of structured mesh. Depending on the intensity, impingement angle, and impingement location of transmitted shock wave, the resulting adverse pressure gradient related disturbances on the wedge surface can trigger complex flow physics both in subsonic and supersonic regions. We observe a strong interaction between the deformation of the boundary layer and the bow shock as well as the transmitted shock for high aft angles. Comparison of the obtained results in terms of general flow physics shows that there exists an aft angle threshold value for such interaction which is in the range of 45°-50°.

  7. Reciprocity in Online Markets: Empirical Studies of Auction and Barter Markets

    ERIC Educational Resources Information Center

    Ye, Shun

    2013-01-01

    My dissertation seeks to understand how reciprocity affects transaction outcomes and mechanism design in online markets. The first essay examines negative reciprocity illustrated as feedback-revoking behavior in the eBay auction market, focusing on its impact and implications for reputation system design. I utilize the biggest policy change of…

  8. Analysis of Bidding Behaviors in Non-monetary Incentivized, Real-Time Uniform Auctions

    DTIC Science & Technology

    2010-12-01

    of experimentation for all participants. The study focuses primarily on implementing an improved SRB program using auction mechanisms incorporating...of Management and Budget, Paperwork Reduction Project (0704-0188) Washington DC 20503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE December...47 C. CONCLUSION AND RECOMMENDATION FOR FURTHER STUDY

  9. Reciprocity in Online Markets: Empirical Studies of Auction and Barter Markets

    ERIC Educational Resources Information Center

    Ye, Shun

    2013-01-01

    My dissertation seeks to understand how reciprocity affects transaction outcomes and mechanism design in online markets. The first essay examines negative reciprocity illustrated as feedback-revoking behavior in the eBay auction market, focusing on its impact and implications for reputation system design. I utilize the biggest policy change of…

  10. China’s Land Market Auctions: Evidence of Corruption?

    PubMed Central

    Cai, Hongbin; Henderson, J. Vernon; Zhang, Qinghua

    2013-01-01

    This paper studies the urban land market in China in 2003—2007. In China, all urban land is owned by the state. Leasehold use rights for land for (re)development are sold by city governments and are a key source of city revenue. Leasehold sales are viewed as a major venue for corruption, prompting a number of reforms over the years. Reforms now require all leasehold rights be sold at public auction. There are two main types of auction: regular English auction and an unusual type which we call a “two stage auction”. The latter type of auction seems more subject to corruption, and to side deals between potential bidders and the auctioneer. Absent corruption, theory suggests that two stage auctions would most likely maximize sales revenue for properties which are likely to have relatively few bidders, or are “cold”, which would suggest negative selection on property unobservables into such auctions. However, if such auctions are more corruptible, that could involve positive selection as city officials divert hotter properties to a more corruptible auction form. The paper finds that, overall, sales prices are lower for two stage auctions, and there is strong evidence of positive selection. The price difference is explained primarily by the fact that two stage auctions typically have just one bidder, or no competition despite the vibrant land market in Chinese cities. PMID:25506125

  11. 47 CFR 1.2208 - Public notice of auction completion and auction results.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PROCEDURE Grants by Random Selection Competitive Bidding Proceedings Broadcast Television Spectrum Reverse... broadcast television spectrum incentive auction conducted under section 6403 of the Spectrum Act, public... indicate that the reassignments of television channels and reallocations of broadcast television...

  12. Analysis of femtosecond quantum control mechanisms with colored double pulses

    SciTech Connect

    Vogt, Gerhard; Nuernberger, Patrick; Selle, Reimer; Dimler, Frank; Brixner, Tobias; Gerber, Gustav

    2006-09-15

    Fitness landscapes based on a limited number of laser pulse shape parameters can elucidate reaction pathways and can help to find the underlying control mechanism of optimal pulses determined by adaptive femtosecond quantum control. In a first experiment, we employ colored double pulses and systematically scan both the temporal subpulse separation and the relative amplitude of the two subpulses to acquire fitness landscapes. Comparison with results obtained from a closed-loop experiment demonstrates the capability of fitness landscapes for the revelation of possible control mechanisms. In a second experiment, using transient absorption spectroscopy, we investigate and compare the dependence of the excitation efficiency of the solvated dye molecule 5,5{sup '}-dichloro-11-diphenylamino-3,3{sup '}-diethyl-10,12-ethylene thiatricarbocyanine perchlorate (IR140) on selected pulse shapes in two parametrizations. The results show that very different pulse profiles can be equivalently adequate to maximize a given control objective. Fitness landscapes thus provide valuable information about different pathways along which a molecular system can be controlled with shaped laser pulses.

  13. Books at Auction: The Art of Deaccessioning.

    ERIC Educational Resources Information Center

    Model, Peter

    1981-01-01

    Lack of space and budget cuts force many libraries to weed out books and to be selective in accepting collection bequests. The approach for deciding which books to weed out and whether to dispose of these books through dealers or auctions are decisions private clubs and many libraries must make. (RBF)

  14. Books at Auction: The Art of Deaccessioning.

    ERIC Educational Resources Information Center

    Model, Peter

    1981-01-01

    Lack of space and budget cuts force many libraries to weed out books and to be selective in accepting collection bequests. The approach for deciding which books to weed out and whether to dispose of these books through dealers or auctions are decisions private clubs and many libraries must make. (RBF)

  15. 43 CFR 2546.4 - Public auctions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Public auctions. 2546.4 Section 2546.4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) COLOR-OF-TITLE AND OMITTED LANDS Snake...

  16. 43 CFR 2546.4 - Public auctions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Public auctions. 2546.4 Section 2546.4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) COLOR-OF-TITLE AND OMITTED LANDS Snake...

  17. 43 CFR 2546.4 - Public auctions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Public auctions. 2546.4 Section 2546.4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) COLOR-OF-TITLE AND OMITTED LANDS Snake...

  18. 43 CFR 2546.4 - Public auctions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Public auctions. 2546.4 Section 2546.4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) COLOR-OF-TITLE AND OMITTED LANDS Snake...

  19. Experiments in Deaccessioning: Archives and Online Auctions.

    ERIC Educational Resources Information Center

    Doylen, Michael

    2001-01-01

    Discussion of the need for archives to remove duplicate or unneeded materials from their collection focuses on the legal and ethical issues raised for archives by the use of online auction venues in deaccessioning unwanted materials, based on experiences at the University of Wisconsin. (Author/LRW)

  20. Fluid mechanics of DNA double-strand filter elution.

    PubMed

    Rudinger, George; Blazek, Ed Robert

    2002-01-01

    Measurement of infrequent DNA double-strand breaks (DSB) in mammalian cells is essential for the understanding of cell damage by ionizing radiation and many DNA-reactive drugs. One of the most important assays for measuring DSB in cellular DNA is filter elution. This study is an attempt to determine whether standard concepts of fluid mechanics can yield a self-consistent model of this process. Major assumptions of the analysis are reptation through a channel formed by surrounding strands, with only strand ends captured by filter pores. Both viscosity and entanglement with surrounding strands are considered to determine the resistance to this motion. One important result is that the average elution time of a strand depends not only on its length, but also on the size distribution of the surrounding strands. This model is consistent with experimental observations, such as the dependence of elution kinetics upon radiation dose, but independence from the size of the DNA sample up to a critical filter loading, and possible overlap of elution times for strands of different length. It indicates how the dependence of elution time on the flow rate could reveal the relative importance of viscous and entanglement resistance, and also predicts the consequences of using different filters.

  1. Fluid mechanics of DNA double-strand filter elution.

    PubMed Central

    Rudinger, George; Blazek, Ed Robert

    2002-01-01

    Measurement of infrequent DNA double-strand breaks (DSB) in mammalian cells is essential for the understanding of cell damage by ionizing radiation and many DNA-reactive drugs. One of the most important assays for measuring DSB in cellular DNA is filter elution. This study is an attempt to determine whether standard concepts of fluid mechanics can yield a self-consistent model of this process. Major assumptions of the analysis are reptation through a channel formed by surrounding strands, with only strand ends captured by filter pores. Both viscosity and entanglement with surrounding strands are considered to determine the resistance to this motion. One important result is that the average elution time of a strand depends not only on its length, but also on the size distribution of the surrounding strands. This model is consistent with experimental observations, such as the dependence of elution kinetics upon radiation dose, but independence from the size of the DNA sample up to a critical filter loading, and possible overlap of elution times for strands of different length. It indicates how the dependence of elution time on the flow rate could reveal the relative importance of viscous and entanglement resistance, and also predicts the consequences of using different filters. PMID:11751292

  2. Double Higgs mechanisms, supermassive stable particles and the vacuum energy

    NASA Astrophysics Data System (ADS)

    Santillán, Osvaldo P.; Gabbanelli, Luciano

    2016-07-01

    In the present work, a hidden scenario which cast a long-lived superheavy particle A0 and simultaneously an extremely light particle a with mass ma ˜ 10-32-10-33 eV is presented. The potential energy V (a) of the particle a models the vacuum energy density of the universe ρc ≃ 10-47GeV4. On the other hand, the A0 particle may act as superheavy dark matter at present times and the products of its decay may be observed in high energy cosmic ray events. The hidden sector proposed here include light fermions with masses near the neutrino mass mν ˜ 10-2 eV and superheavy ones with masses of the order of the GUT scale, interacting through a hidden SU(2)L interaction which also affects the ordinary sector. The construction of such combined scenario is nontrivial since the presence of light particles may spoil the stability of the heavy particle A0. However, double Higgs mechanisms may be helpful for overcoming this problem. In this context, the stability of the superheavy particle A0 is ensured due to chiral symmetry arguments elaborated in the text.

  3. Increasing the Effectiveness of Navy Retention Compensation by Evaluating Different Auction Compensation Formats

    DTIC Science & Technology

    2015-06-01

    distribution. This thesis studies three different types of auctions, and examines which auction would be utilized best by the government as a retention...results of the experiment showed that discriminatory auctions fared best overall. Sealed bid- discriminatory auctions had a significant savings of 5.1...examines which auction would be utilized best by the government as a retention tool. The three auctions analyzed were a sealed bid-discriminatory

  4. On Revenue-Optimal Dynamic Auctions for Bidders with Interdependent Values

    NASA Astrophysics Data System (ADS)

    Constantin, Florin; Parkes, David C.

    In a dynamic market, being able to update one's value based on information available to other bidders currently in the market can be critical to having profitable transactions. This is nicely captured by the model of interdependent values (IDV): a bidder's value can explicitly depend on the private information of other bidders. In this paper we present preliminary results about the revenue properties of dynamic auctions for IDV bidders. We adopt a computational approach to design single-item revenue-optimal dynamic auctions with known arrivals and departures but (private) signals that arrive online. In leveraging a characterization of truthful auctions, we present a mixed-integer programming formulation of the design problem. Although a discretization is imposed on bidder signals the solution is a mechanism applicable to continuous signals. The formulation size grows exponentially in the dependence of bidders' values on other bidders' signals. We highlight general properties of revenue-optimal dynamic auctions in a simple parametrized example and study the sensitivity of prices and revenue to model parameters.

  5. Ribonuclease III mechanisms of double-stranded RNA cleavage.

    PubMed

    Nicholson, Allen W

    2014-01-01

    Double-stranded(ds) RNA has diverse roles in gene expression and regulation, host defense, and genome surveillance in bacterial and eukaryotic cells. A central aspect of dsRNA function is its selective recognition and cleavage by members of the ribonuclease III (RNase III) family of divalent-metal-ion-dependent phosphodiesterases. The processing of dsRNA by RNase III family members is an essential step in the maturation and decay of coding and noncoding RNAs, including miRNAs and siRNAs. RNase III, as first purified from Escherichia coli, has served as a biochemically well-characterized prototype, and other bacterial orthologs provided the first structural information. RNase III family members share a unique fold (RNase III domain) that can dimerize to form a structure that binds dsRNA and cleaves phosphodiesters on each strand, providing the characteristic 2 nt, 3'-overhang product ends. Ongoing studies are uncovering the functions of additional domains, including, inter alia, the dsRNA-binding and PAZ domains that cooperate with the RNase III domain to select target sites, regulate activity, confer processivity, and support the recognition of structurally diverse substrates. RNase III enzymes function in multicomponent assemblies that are regulated by diverse inputs, and at least one RNase III-related polypeptide can function as a noncatalytic, dsRNA-binding protein. This review summarizes the current knowledge of the mechanisms of catalysis and target site selection of RNase III family members, and also addresses less well understood aspects of these enzymes and their interactions with dsRNA. © 2013 The Authors. WIREs RNA published by John Wiley & Sons, Ltd.

  6. Market power in auction and efficiency in emission permits allocation.

    PubMed

    Jiang, Min Xing; Yang, Dong Xiao; Chen, Zi Yue; Nie, Pu Yan

    2016-12-01

    This paper analyzes how to achieve the cost-effectiveness by initial allocation of CO2 emission permits when a single dominant firm in production market has market power in auction, and compare two prevalent allocation patterns, mixed allocation and single auction. We show how the firm with market power may manipulate the auction price, thereby this leads to fail to achieve cost-effective solution by auction unless the total permits for allocation equal to the effective emissions cap. Provided that the market power firm receives strictly positive free permits, the effective emissions cap of mixed allocation is larger than that of single auction. The production market share of dominant firm is increasing with the free permits it holds. Finally, we examine the compliance costs and welfare of mixed allocation and single auction, the result show that the former is preferred to the later when policy makers consider economic welfare without welfare cost due to CO2 emissions.

  7. Auction design and the market for sulfur dioxide emissions

    SciTech Connect

    Joskow, P.L.; Schmalensee, R.; Bailey, E.M.

    1997-12-31

    Title IV of the Clean Air Act Amendments of 1990 created a market for electric utility emissions of sulfur dioxide (SO{sub 2}). Recent papers have argued that flaws in the design of the auctions that are part of this market have adversely affected its performance. These papers incorrectly assume that trade can only occur at auctions, however. Our empirical analysis of the SO{sub 2} emissions market shows that the auctions have become a small part of a relatively efficient market and that the auction design problems that have attracted the most attention have had no effect on actual market prices.

  8. Auctions vs negotiations: a study of price differentials.

    PubMed

    Kjerstad, Egil

    2005-12-01

    Recent contributions in auction and bargaining theory suggest that a procurer should place more faith in the power of competition among alternative suppliers than in his or her own negotiating skill. Based on data from 216 contracts between procurers and suppliers of medical and surgical articles, we test whether auctions and bargaining result in significantly different prices. The main results are that auctions give 'thicker' markets compared with negotiations, as expected, but that auctions do not result in significantly lower prices compared with negotiations.

  9. Mechanisms of Strong-Field Double Ionization of Xe

    NASA Astrophysics Data System (ADS)

    Sun, Xufei; Li, Min; Ye, Difa; Xin, Guoguo; Fu, Libin; Xie, Xiguo; Deng, Yongkai; Wu, Chengyin; Liu, Jie; Gong, Qihuang; Liu, Yunquan

    2014-09-01

    We perform a fully differential measurement on strong-field double ionization of Xe by 25 fs, 790 nm laser pulses in intensity region (0.4-3)×1014 W/cm2. We observe that the two-dimensional correlation momentum spectra along the laser polarization direction show a nonstructured distribution for double ionization of Xe when decreasing the laser intensity from 3×1014 to 4×1013 W /cm2. The electron correlation behavior is remarkably different with the low-Z rare gases, i.e., He, Ne, and Ar. We find that the electron energy cutoffs increase from 2.9Up to 7.8Up when decreasing the laser intensities from the sequential double ionization to the nonsequential double ionization regime. The experimental observation indicates that multiple rescatterings play an important role for the generation of high energy photoelectrons. We have further studied the shielding effect on the strong-field double ionization of high-Z atoms.

  10. Deformation effect simulation and optimization for double front axle steering mechanism

    NASA Astrophysics Data System (ADS)

    Wu, Jungang; Zhang, Siqin; Yang, Qinglong

    2013-03-01

    This paper research on tire wear problem of heavy vehicles with Double Front Axle Steering Mechanism from the flexible effect of Steering Mechanism, and proposes a structural optimization method which use both traditional static structural theory and dynamic structure theory - Equivalent Static Load (ESL) method to optimize key parts. The good simulated and test results show this method has high engineering practice and reference value for tire wear problem of Double Front Axle Steering Mechanism design.

  11. Health Auctions: a Valuation Experiment (HAVE) study protocol

    PubMed Central

    Kularatna, Sanjeewa; Petrie, Dennis; Scuffham, Paul A; Byrnes, Joshua

    2016-01-01

    Introduction Quality-adjusted life years are derived using health state utility weights which adjust for the relative value of living in each health state compared with living in perfect health. Various techniques are used to estimate health state utility weights including time-trade-off and standard gamble. These methods have exhibited limitations in terms of complexity, validity and reliability. A new composite approach using experimental auctions to value health states is introduced in this protocol. Methods and analysis A pilot study will test the feasibility and validity of using experimental auctions to value health states in monetary terms. A convenient sample (n=150) from a population of university staff and students will be invited to participate in 30 auction sets with a group of 5 people in each set. The 9 health states auctioned in each auction set will come from the commonly used EQ-5D-3L instrument. At most participants purchase 2 health states, and the participant who acquires the 2 ‘best’ health states on average will keep the amount of money they do not spend in acquiring those health states. The value (highest bid and average bid) of each of the 24 health states will be compared across auctions to test for reliability across auction groups and across auctioneers. A test retest will be conducted for 10% of the sample to assess reliability of responses for health states auctions. Feasibility of conducting experimental auctions to value health states will also be examined. The validity of estimated health states values will be compared with published utility estimates from other methods. This pilot study will explore the feasibility, reliability and validity in using experimental auction for valuing health states. Ethics and dissemination Ethical clearance was obtained from Griffith University ethics committee. The results will be disseminated in peer-reviewed journals and major international conferences. PMID:27056589

  12. Health Auctions: a Valuation Experiment (HAVE) study protocol.

    PubMed

    Kularatna, Sanjeewa; Petrie, Dennis; Scuffham, Paul A; Byrnes, Joshua

    2016-04-07

    Quality-adjusted life years are derived using health state utility weights which adjust for the relative value of living in each health state compared with living in perfect health. Various techniques are used to estimate health state utility weights including time-trade-off and standard gamble. These methods have exhibited limitations in terms of complexity, validity and reliability. A new composite approach using experimental auctions to value health states is introduced in this protocol. A pilot study will test the feasibility and validity of using experimental auctions to value health states in monetary terms. A convenient sample (n=150) from a population of university staff and students will be invited to participate in 30 auction sets with a group of 5 people in each set. The 9 health states auctioned in each auction set will come from the commonly used EQ-5D-3L instrument. At most participants purchase 2 health states, and the participant who acquires the 2 'best' health states on average will keep the amount of money they do not spend in acquiring those health states. The value (highest bid and average bid) of each of the 24 health states will be compared across auctions to test for reliability across auction groups and across auctioneers. A test retest will be conducted for 10% of the sample to assess reliability of responses for health states auctions. Feasibility of conducting experimental auctions to value health states will also be examined. The validity of estimated health states values will be compared with published utility estimates from other methods. This pilot study will explore the feasibility, reliability and validity in using experimental auction for valuing health states. Ethical clearance was obtained from Griffith University ethics committee. The results will be disseminated in peer-reviewed journals and major international conferences. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a

  13. Elucidating the mechanisms of double ionization using intense half-cycle, single-cycle, and double half-cycle pulses

    SciTech Connect

    Kamta, G. Lagmago; Starace, Anthony F.

    2003-10-01

    We investigate the interaction of a two-active electron system (Li{sup -}) with intense single-cycle and double half-cycle pulses. The 'intensity' and 'frequency' considered correspond to the 'multiphoton above-barrier regime'. For the single-cycle pulse (SCP), the electric field changes sign once, allowing electron wave packets created during the first half cycle to recollide with the parent ion when driven back by the field. For the double half-cycle pulse (DHP), however, the electric field does not change sign, and electron wave packets created during the first half cycle are not driven back to the parent ion. We find that both single and double ionization are significantly larger for the SCP than for the DHP, thereby elucidating the role of the rescattering mechanism. On the other hand, doubly ionized electrons produced by a half-cycle pulse and a DHP are found to have angular distributions in which one electron is ejected in the direction of the pulse field, and the other in the opposite direction. This clear signature of electron correlations suggests that 'shake-off', 'knockout', and, possibly, 'multiphoton-sharing' processes are alternative contributing mechanisms for double ionization in this regime.

  14. The Double-Well Potential in Quantum Mechanics: A Simple, Numerically Exact Formulation

    ERIC Educational Resources Information Center

    Jelic, V.; Marsiglio, F.

    2012-01-01

    The double-well potential is arguably one of the most important potentials in quantum mechanics, because the solution contains the notion of a state as a linear superposition of "classical" states, a concept which has become very important in quantum information theory. It is therefore desirable to have solutions to simple double-well potentials…

  15. The Double-Well Potential in Quantum Mechanics: A Simple, Numerically Exact Formulation

    ERIC Educational Resources Information Center

    Jelic, V.; Marsiglio, F.

    2012-01-01

    The double-well potential is arguably one of the most important potentials in quantum mechanics, because the solution contains the notion of a state as a linear superposition of "classical" states, a concept which has become very important in quantum information theory. It is therefore desirable to have solutions to simple double-well potentials…

  16. Double breaks in vacuum: Technical benefit and flashover mechanism

    SciTech Connect

    Sentker, P.; Kaerner, H.C.

    1996-12-31

    The success of vacuum medium voltage switchgears bases on the high performance of vacuum interrupters for clearances up to 15 mm. Due to the vacuum specific flashover processes a degressive rise of the breakdown voltage with enlarging gap space is observed. This effect prevents nowadays an economic inset of vacuum technology in high-voltage applications above 53 kV. The authors investigate the breakdown voltage of double break arrangements because of the high performance of small vacuum gaps. A possible high voltage interrupter could consist of a static mid-electrode and two movable contact elements. Their aim is to show whether double (or multiple) breaks are able to increase the electric strength in vacuum.

  17. Efficient power control via auction in WCDMA systems

    NASA Astrophysics Data System (ADS)

    Zhang, Chi; Zhang, Xia; Wei, Jiaolong; Zhou, Manli

    2002-08-01

    This paper investigates the power control mechanism in the context of third generation multimedia multirate wideband CDMA (WCDMA) mobile communications. We first present the system model and get the sufficient condition for the existence of feasible power assignment. Under this constraint, we reformulate the power control problem as a non-cooperative game in allocating the normalized QoS products, and propose a new call admission control (CAC) algorithm based on uniform-price auction (UPA) to control the power. Properties of UPA Nash equilibrium, especially its efficiency, are also discussed in wireless system environment. The results of comparison show that our scheme charging users on the QoS products has the enormous advantage over other pricing schemes charging users directly on the transmit powers. Numerical results which demonstrate the viability of the proposed algorithm are presented.

  18. Mechanical Response and Shear Initiation of Double-Base Propellants

    DTIC Science & Technology

    2009-08-01

    dynamic shear punch test using a modified split- Hopkinson bar. Varying the striker bar’s velocity and length controls the shear rate and duration. Shear...for double-base propellants and computational results of the shear punch test . For the simulations, the viscoSCRAM constitutive model was used to...initiation is determined based on their ability to predict the observed response from the dynamic shear punch test . 15. SUBJECT TERMS insensitive

  19. A Combinatorial Auction among Versatile Experts and Amateurs

    NASA Astrophysics Data System (ADS)

    Ito, Takayuki; Yokoo, Makoto; Matsubara, Shigeo

    Auctions have become an integral part of electronic commerce and a promising field for applying multi-agent technologies. Correctly judging the quality of auctioned goods is often difficult for amateurs, in particular, in Internet auctions. However, experts can correctly judge the quality of goods. In this situation, it is difficult to make experts tell the truth and attain an efficient allocation, since experts have a clear advantage over amateurs and they would not reveal their valuable information without some reward. In our previous work, we have succeeded in developing such auction protocols under the following two cases: (1) the case of a single-unit auction among experts and amateurs, and (2) the case of a combinatorial auction among single-skilled experts and amateurs. In this paper, we focus on versatile experts. Versatile experts have an interest in, and expert knowledge on the qualities of several goods. In the case of versatile experts, there would be several problems, e.g., free riding problems, if we simply extended the previous VCG-style auction protocol. Thus, in this paper, we employ PORF (price-oriented, rationing-free) protocol for designing our new protocol to realize a strategy-proof auction protocol for experts. In the protocol, the dominant strategy for experts is truth-telling. Also, for amateurs, truth-telling is the best response when two or more experts select the dominant strategy. Furthermore, the protocol is false-name-proof.

  20. A Classroom Auction with Externalities: Applied to Mergers and Acquisitions

    ERIC Educational Resources Information Center

    Meister, J. Patrick; Anderson, Kyle J.

    2007-01-01

    The authors describe an in-class exercise in which students participate in an auction to buy US Airways. The exercise is based on events of late 1995, in which neither United nor American Airlines decided to bid for US Airways. Two teams of students participate in an English auction. Students learn that the equilibrium of the sequential game is…

  1. A Classroom Auction with Externalities: Applied to Mergers and Acquisitions

    ERIC Educational Resources Information Center

    Meister, J. Patrick; Anderson, Kyle J.

    2007-01-01

    The authors describe an in-class exercise in which students participate in an auction to buy US Airways. The exercise is based on events of late 1995, in which neither United nor American Airlines decided to bid for US Airways. Two teams of students participate in an English auction. Students learn that the equilibrium of the sequential game is…

  2. 77 FR 38803 - Mobility Fund Phase I Auction Updated Data For Auction 901

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... subsequently released geographic information system (GIS) formats of the data shown in the interactive map. The... search function for AU Docket No. 12-25 on the Commission's Electronic Comment Filing System (ECFS) Web... with the release of Auction 901 Procedures Public Notice, the Bureaus released an interactive map...

  3. Detecting Fraud in Internet Auction Systems

    NASA Astrophysics Data System (ADS)

    Peng, Yanlin; Zhang, Linfeng; Guan, Yong

    Fraud compromises the thriving Internet auction market. Studies have shown that fraudsters often manipulate their reputations through sophisticated collusions with accomplices, enabling them to defeat the reputation-based feedback systems that are used to combat fraud. This paper presents an algorithm that can identify colluding fraudsters in real time. Experiments with eBay transaction data show that the algorithm has low false negative and false positive rates. Furthermore, the algorithm can identify fraudsters who are innocent at the time of the data collection, but engage in fraudulent transactions soon after they accumulate good feedback ratings.

  4. On The Physical Mechanism At The Origin Of Multiple Double Layers Appearance In Plasma

    SciTech Connect

    Dimitriu, D. G.; Gurlui, S.; Aflori, M.; Ivan, L. M.

    2006-01-15

    Double layer in plasma are nonlinear potential structures consisting of two adjacent layers of positive and negative space charges, respectively. Between these layers a potential jump exists, creating an electric field. A common way to obtain a double layer structure is to positively bias an electrode immersed into stable plasma. Under certain experimental conditions, a more complex structure in form of two or more subsequent double layers was observed, which was called multiple double layers. It appears as several bright and concentric plasma shells attached to the electrode. The successive double layers are located at the abrupt changes of luminosity between two adjacent plasma shells. However, if the electrode is large, the multiple double layers structure appears non-concentrically, as a network of plasma spots, near each other, almost equally distributed on the electrode surface. Each of the plasma spots is confined by an electrical double layer. Here, we will present experimental results on the appearance and dynamics of concentric, as well as non-concentric multiple double layers. The results prove that the same physical mechanism is at the origin of their appearance in plasma. In this mechanism, the electron-neutral impact excitations and ionizations play the key role.

  5. Attacks and Improvement of Quantum Sealed-Bid Auction with EPR Pairs

    NASA Astrophysics Data System (ADS)

    Liu, Wen-Jie; Wang, Fang; Ji, Sai; Qu, Zhi-Guo; Wang, Xiao-Jun

    2014-06-01

    Recently, an experimentally feasible three-party quantum sealed-bid auction protocol based on EPR pairs [Z.Y. Wang, Commun. Theor. Phys. 54 (2010) 997] was proposed. However, this study points out Wang's protocol cannot resist some internal bidders' attacks, such as the Twice-CNOT attack, the collusion attack. A malicious bidder can launch the Twice-CNOT attack to obtain the other's bid, or the dishonest auctioneer may collude with one bidder and help him/her win the action by changing his/her bid. For preventing against these attacks, a simple solution by using the QKD-based message encryption and a post-confirmation mechanism by adopting the hash function are proposed.

  6. Rationality, Irrationality and Escalating Behavior in Lowest Unique Bid Auctions

    PubMed Central

    Radicchi, Filippo; Baronchelli, Andrea; Amaral, Luís A. N.

    2012-01-01

    Information technology has revolutionized the traditional structure of markets. The removal of geographical and time constraints has fostered the growth of online auction markets, which now include millions of economic agents worldwide and annual transaction volumes in the billions of dollars. Here, we analyze bid histories of a little studied type of online auctions – lowest unique bid auctions. Similarly to what has been reported for foraging animals searching for scarce food, we find that agents adopt Lévy flight search strategies in their exploration of “bid space”. The Lévy regime, which is characterized by a power-law decaying probability distribution of step lengths, holds over nearly three orders of magnitude. We develop a quantitative model for lowest unique bid online auctions that reveals that agents use nearly optimal bidding strategies. However, agents participating in these auctions do not optimize their financial gain. Indeed, as long as there are many auction participants, a rational profit optimizing agent would choose not to participate in these auction markets. PMID:22279553

  7. Rationality, irrationality and escalating behavior in lowest unique bid auctions.

    PubMed

    Radicchi, Filippo; Baronchelli, Andrea; Amaral, Luís A N

    2012-01-01

    Information technology has revolutionized the traditional structure of markets. The removal of geographical and time constraints has fostered the growth of online auction markets, which now include millions of economic agents worldwide and annual transaction volumes in the billions of dollars. Here, we analyze bid histories of a little studied type of online auctions--lowest unique bid auctions. Similarly to what has been reported for foraging animals searching for scarce food, we find that agents adopt Lévy flight search strategies in their exploration of "bid space". The Lévy regime, which is characterized by a power-law decaying probability distribution of step lengths, holds over nearly three orders of magnitude. We develop a quantitative model for lowest unique bid online auctions that reveals that agents use nearly optimal bidding strategies. However, agents participating in these auctions do not optimize their financial gain. Indeed, as long as there are many auction participants, a rational profit optimizing agent would choose not to participate in these auction markets.

  8. The communications spectrum: Frequency allocations and auctions

    NASA Astrophysics Data System (ADS)

    Pritchard, Wilbur

    1997-01-01

    Demands on the communications spectrum have increased sharply because of the growth in radio communication services, the large bandwidths now required, and the rapid increases in world population. The problem will be exacerbated by the requirements of high definition television and the enormous amounts of information that will be transmitted by radio. The electromagnetic spectrum is a finite natural resource of great value used for emergency communications and military operations as well as for commercial purposes. Both government and the marketplace have proper roles in the allocation of its resources. There are no viable alternatives to international organizations such as the International Telecommunication Union or to agencies such as the Federal Communications Commission for the regulation of radio communication and the assignment of spectrum to essential public services. Although government auctions of spectrum are justifiable where there is no way to distinguish among commercial entities seeking to use the same bands for similar services, the practice is inherently inequitable and discourages development of new uses for the spectrum by removing investment protection. Recommended alternatives to auctions are: (1) lotteries, which keep assets and proceeds in the economy; and (2) ongoing charges for current as well as new users of the spectrum.

  9. Non-double-couple earthquake mechanisms at the Geysers geothermal area, California

    USGS Publications Warehouse

    Ross, A.; Foulger, G.R.; Julian, B.R.

    1996-01-01

    Inverting P- and S-wave polarities and P:SH amplitude ratios using linear programming methods suggests that about 20% of earthquakes at The Geysers geothermal area have significantly non-double-couple focal mechanisms, with explosive volumetric components as large as 33% of the seismic moment. This conclusion contrasts with those of earlier studies, which interpreted data in terms of double couples. The non-double-couple mechanisms are consistent with combined shear and tensile faulting, possibly caused by industrial water injection. Implosive mechanisms, which might be expected because of rapid steam withdrawal, have not been found. Significant compensated-linear-vector-dipole (CLVD) components in some mechanisms may indicate rapid fluid flow accompanying crack opening. Copyright 1996 by the American Geophysical Union.

  10. On the Economic Effects of Competition between Double Auction Markets

    NASA Astrophysics Data System (ADS)

    Cai, Kai; Niu, Jinzhong; Parsons, Simon

    Real market institutions, stock and commodity exchanges for example, do not occur in isolation. The same stocks and commodities may be listed on multiple exchanges, and traders who want to deal in those goods have a choice of markets in which to trade. While there has been extensive research into agent-based trading in individual markets, there is little work on this kind of multiple market scenario. Our work seeks to address this imbalance. In particular, this paper examines how allocative efficiency, the standard measure of a market's ability to extract surplus, is affected by the presence of multiple markets for the same good. We find that while dividing traders between several small markets typically leads to lower efficiency than grouping them into one large market, the movement of traders between markets, and price incentives for changing markets, can reduce this loss of efficiency.

  11. A double vacuum window mechanism for space-borne applications.

    PubMed

    Zilic, K; Aboobaker, A; Aubin, F; Geach, C; Hanany, S; Jarosik, N; Milligan, M; Sagiv, I

    2017-04-01

    We present a vacuum window mechanism that is useful for applications requiring two different vacuum windows in series, with one of them movable and resealable. Such applications include space borne instruments that can benefit from a thin vacuum window at low ambient pressures but must also have an optically open aperture at atmospheric pressures. We describe the implementation and successful operation with the E and B experiment balloon-borne payload, a millimeter-wave instrument designed to measure the polarization of the cosmic microwave background radiation.

  12. 6. East rear, cattle auction arena below in background, Omaha ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. East rear, cattle auction arena below in background, Omaha livestock market offices above. View to west. - South Omaha Union Stock Yards, Stock Yards Autopark, 2900 "O" Plaza, Omaha, Douglas County, NE

  13. Double deck bridge behavior and failure mechanism under seismic motions using nonlinear analyzes

    NASA Astrophysics Data System (ADS)

    Alali, Shirin; Li, Jianzhong; Guo, Guanzhong

    2013-09-01

    This paper investigates the behavior and the failure mechanism of a double deck bridge constructed in China through nonlinear time history analysis. A parametric study was conducted to evaluate the influence of different structural characteristics on the behavior of the double deck bridge under transverse seismic motions, and to detect the effect of bidirectional loading on the seismic response of this type of bridge. The results showed that some characteristics, such as the variable lateral stiffness, the foundation modelling, and the longitudinal reinforcement ratio of the upper and lower columns of the bridge pier bents have a major impact on the double deck bridge response and its failure mechanism under transverse seismic motions. It was found that the soft story failure mechanism is not unique to the double deck bridge and its occurrence is related to some conditions and structural characteristics of the bridge structure. The analysis also showed that the seismic vulnerability of the double deck bridge under bi-directional loading was severely increased compared to the bridge response under unidirectional transverse loading, and out-of-phase movements were triggered between adjacent girders.

  14. Physical mechanisms of active control of sound transmission through rib stiffened double-panel structure

    NASA Astrophysics Data System (ADS)

    Ma, Xiyue; Chen, Kean; Ding, Shaohu; Yu, Haoxin

    2016-06-01

    This paper presents an analytical investigation on physical mechanisms of actively controlling sound transmission through a rib stiffened double-panel structure using point source in the cavity. The combined modal expansion and vibro-acoustic coupling methods are applied to establish the theoretical model of such active structure. Under the condition of minimizing radiated power of the radiating ribbed plate, the physical mechanisms are interpreted in detail from the point of view of modal couplings similar as that used in existed literatures. Results obtained demonstrate that the rule of sound energy transmission and the physical mechanisms for the rib stiffened double-panel structure are all changed, and affected by the coupling effects of the rib when compared with the analytical results obtained for unribbed double-panel case. By taking the coupling effects of the rib into considerations, the cavity modal suppression and rearrangement mechanisms obtained in existed investigations are modified and supplemented for the ribbed plate case, which gives a clear interpretation for the physical nature involved in the active rib stiffened double-panel structure.

  15. 31 CFR 356.23 - How are the auction results announced?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... conclusion of the auction, we will announce the auction results through a press release that is available on our Web site at http://www.treasurydirect.gov. (b) The press release will include such information...

  16. Competition in decentralized electricity markets: Three papers on electricity auctions

    NASA Astrophysics Data System (ADS)

    Harbord, David William Cameron

    This thesis consists of three self-contained papers on the analysis of electricity auctions written over a period of twelve years. The first paper models price competition in a decentralized wholesale market for electricity as a first-price, sealed-bid, multi-unit auction. In both the pure and mixed-strategy equilibria of the model, above marginal cost pricing and inefficient despatch of generating units occur. An alternative regulatory pricing rule is considered and it is shown that offering to supply at marginal cost can be induced as a dominant strategy for all firms. The second paper analyses strategic interaction between long-term contracts and price competition in the British electricity wholesale market, and confirms that forward contracts will tend to put downward pressure on spot market prices. A 'strategic commitment' motive for selling forward contracts is also identified: a generator may commit itself to bidding lower prices into the spot market in order to ensure that it will be despatched with its full capacity. The third paper characterizes bidding behavior and market outcomes in uniform and discriminatory electricity auctions. Uniform auctions result in higher average prices than discriminatory auctions, but the ranking in terms of productive efficiency is ambiguous. The comparative effects of other market design features, such as the number of steps in suppliers' bid functions, the duration of bids and the elasticity of demand are analyzed. The paper also clarifies some methodological issues in the analysis of electricity auctions. In particular we show that analogies with continuous share auctions are misplaced so long as firms are restricted to a finite number of bids.

  17. 9 CFR 2.76 - Records: Operators of auction sales and brokers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Records: Operators of auction sales..., DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Records § 2.76 Records: Operators of auction sales and brokers. (a) Every operator of an auction sale or broker shall make, keep, and maintain records or...

  18. Using Laboratory Experiments for Policymaking: An Example from the Georgia Irrigation Reduction Auction

    ERIC Educational Resources Information Center

    Cummings, Ronald G.; Holt, Charles A.; Laury, Susan K.

    2004-01-01

    In recent years, interest has been growing in policy applications of different auction systems. This paper reports a series of experiments that were used to design and implement an auction in a unique policymaking environment. In April 2000, the Georgia legislature passed a law that mandated that the state hold an auction in drought years to pay…

  19. Using Laboratory Experiments for Policymaking: An Example from the Georgia Irrigation Reduction Auction

    ERIC Educational Resources Information Center

    Cummings, Ronald G.; Holt, Charles A.; Laury, Susan K.

    2004-01-01

    In recent years, interest has been growing in policy applications of different auction systems. This paper reports a series of experiments that were used to design and implement an auction in a unique policymaking environment. In April 2000, the Georgia legislature passed a law that mandated that the state hold an auction in drought years to pay…

  20. Energy transmission in a mechanically-linked double-wall structure coupled to an acoustic enclosure

    NASA Astrophysics Data System (ADS)

    Cheng, L.; Li, Y. Y.; Gao, J. X.

    2005-05-01

    The energy transmission in a mechanically linked double-wall structure into an acoustic enclosure is studied in this paper. Based on a fully coupled vibro-acoustic formulation, focus is put on investigating the effect of the air gap and mechanical links between the two panels on the energy transmission and noise insulation properties of such structures. An approximate formula reflecting the gap effect on the lower-order coupled frequencies of the system is proposed. A criterion, based on the ratio between the aerostatic stiffness of the gap cavity and the stiffness of the link, is proposed to predict the dominant transmitting path, with a view to provide guidelines for the design of appropriate control strategies. Numerical results reveal the existence of three distinct zones, within which energy transmission takes place following different mechanisms and transmitting paths. Corresponding effects on noise insulation properties of the double-wall structure are also investigated. .

  1. Energy transmission in a mechanically-linked double-wall structure coupled to an acoustic enclosure.

    PubMed

    Cheng, L; Li, Y Y; Gao, J X

    2005-05-01

    The energy transmission in a mechanically linked double-wall structure into an acoustic enclosure is studied in this paper. Based on a fully coupled vibro-acoustic formulation, focus is put on investigating the effect of the air gap and mechanical links between the two panels on the energy transmission and noise insulation properties of such structures. An approximate formula reflecting the gap effect on the lower-order coupled frequencies of the system is proposed. A criterion, based on the ratio between the aerostatic stiffness of the gap cavity and the stiffness of the link, is proposed to predict the dominant transmitting path, with a view to provide guidelines for the design of appropriate control strategies. Numerical results reveal the existence of three distinct zones, within which energy transmission takes place following different mechanisms and transmitting paths. Corresponding effects on noise insulation properties of the double-wall structure are also investigated.

  2. Double-slit experiment with single wave-driven particles and its relation to quantum mechanics.

    PubMed

    Andersen, Anders; Madsen, Jacob; Reichelt, Christian; Rosenlund Ahl, Sonja; Lautrup, Benny; Ellegaard, Clive; Levinsen, Mogens T; Bohr, Tomas

    2015-07-01

    In a thought-provoking paper, Couder and Fort [Phys. Rev. Lett. 97, 154101 (2006)] describe a version of the famous double-slit experiment performed with droplets bouncing on a vertically vibrated fluid surface. In the experiment, an interference pattern in the single-particle statistics is found even though it is possible to determine unambiguously which slit the walking droplet passes. Here we argue, however, that the single-particle statistics in such an experiment will be fundamentally different from the single-particle statistics of quantum mechanics. Quantum mechanical interference takes place between different classical paths with precise amplitude and phase relations. In the double-slit experiment with walking droplets, these relations are lost since one of the paths is singled out by the droplet. To support our conclusions, we have carried out our own double-slit experiment, and our results, in particular the long and variable slit passage times of the droplets, cast strong doubt on the feasibility of the interference claimed by Couder and Fort. To understand theoretically the limitations of wave-driven particle systems as analogs to quantum mechanics, we introduce a Schrödinger equation with a source term originating from a localized particle that generates a wave while being simultaneously guided by it. We show that the ensuing particle-wave dynamics can capture some characteristics of quantum mechanics such as orbital quantization. However, the particle-wave dynamics can not reproduce quantum mechanics in general, and we show that the single-particle statistics for our model in a double-slit experiment with an additional splitter plate differs qualitatively from that of quantum mechanics.

  3. Damping mechanisms of single-clamped and prestressed double-clamped resonant polymer microbeams

    NASA Astrophysics Data System (ADS)

    Schmid, S.; Hierold, C.

    2008-11-01

    In this article, an investigation of the damping mechanisms of resonant single- and double-clamped polymer microbeams for a frequency range from 10 kHz to 5 MHz is presented. The suspended structures are made of SU-8, an epoxy-type photoresist, by means of a sacrificial layer technique. The vibration was measured with a laser-Doppler vibrometer in high vacuum at different temperatures and at atmospheric pressure. The influence of air damping in rarefied air was investigated and the intrinsic damping mechanisms were determined in high vacuum (p <0.05 Pa). After excluding a variety of possible damping factors, the dominant intrinsic dissipation mechanism of the single-clamped microbeams was understood to be the material damping with maximum quality factors (Q) of around 70 at 20 °C. Quality factors of up to 720 at 20 °C were measured for stringlike double-clamped microbeams, which suggest a different intrinsic damping mechanism than material loss. It is shown that internal damping mechanisms due to flexure and elongation have a small impact on the damping of stretched strings. Modeling the clamping loss based on the wave transmission into the suspended anchor plates indicates that it is the dominant intrinsic dissipation in the prestressed double-clamped microresonators. At atmospheric pressure it was shown that at low frequencies the quality factors of single-clamped and stringlike double-clamped microbeams are limited by the squeeze-film air damping. At high frequencies the quality factors are limited by the specific intrinsic damping. In between the two particular regions with a specific dominant damping mechanism the quality factors show a maximum.

  4. Double-slit experiment with single wave-driven particles and its relation to quantum mechanics

    NASA Astrophysics Data System (ADS)

    Andersen, Anders; Madsen, Jacob; Reichelt, Christian; Rosenlund Ahl, Sonja; Lautrup, Benny; Ellegaard, Clive; Levinsen, Mogens T.; Bohr, Tomas

    2015-07-01

    In a thought-provoking paper, Couder and Fort [Phys. Rev. Lett. 97, 154101 (2006), 10.1103/PhysRevLett.97.154101] describe a version of the famous double-slit experiment performed with droplets bouncing on a vertically vibrated fluid surface. In the experiment, an interference pattern in the single-particle statistics is found even though it is possible to determine unambiguously which slit the walking droplet passes. Here we argue, however, that the single-particle statistics in such an experiment will be fundamentally different from the single-particle statistics of quantum mechanics. Quantum mechanical interference takes place between different classical paths with precise amplitude and phase relations. In the double-slit experiment with walking droplets, these relations are lost since one of the paths is singled out by the droplet. To support our conclusions, we have carried out our own double-slit experiment, and our results, in particular the long and variable slit passage times of the droplets, cast strong doubt on the feasibility of the interference claimed by Couder and Fort. To understand theoretically the limitations of wave-driven particle systems as analogs to quantum mechanics, we introduce a Schrödinger equation with a source term originating from a localized particle that generates a wave while being simultaneously guided by it. We show that the ensuing particle-wave dynamics can capture some characteristics of quantum mechanics such as orbital quantization. However, the particle-wave dynamics can not reproduce quantum mechanics in general, and we show that the single-particle statistics for our model in a double-slit experiment with an additional splitter plate differs qualitatively from that of quantum mechanics.

  5. Model of Auctioneer Estimation of Swordtip Squid (Loligo edulis) Quality

    NASA Astrophysics Data System (ADS)

    Nakamura, Makoto; Matsumoto, Keisuke; Morimoto, Eiji; Ezoe, Satoru; Maeda, Toshimichi; Hirano, Takayuki

    The knowledge of experienced auctioneers regarding the circulation of marine products is an essential skill and is necessary for evaluating product quality and managing aspects such as freshness. In the present study, the ability of an auctioneer to quickly evaluate the freshness of swordtip squid (Loligo edulis) at fish markets was analyzed. Evaluation characteristics used by an auctioneer were analyzed and developed using a fuzzy logic model. Forty boxes containing 247 swordtip squid with mantles measuring 220 mm that had been evaluated and assigned to one of five quality categories by an auctioneer were used for the analysis and the modeling. The relationships between the evaluations of appearance, body color, and muscle freshness were statistically analyzed. It was found that a total of four indexes of the epidermis color strongly reflected evaluations of appearance: dispersion ratio of the head, chroma on the head-end mantle and the difference in the chroma and brightness of the mantle. The fuzzy logic model used these indexes for the antecedent-part of the linguistic rules. The results of both simulation and evaluations demonstrate that the model is robust, with the predicted results corresponding with more than 96% of the quality assignments of the auctioneers.

  6. 76 FR 1158 - Auction of 700 MHz Band Licenses Scheduled for July 19, 2011; Comment Sought on Competitive...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ... particular license). Under this proposal, the FCC Auction System interface will list the acceptable bid... and during the auction, through the Commission's Integrated Spectrum Auction System (FCC Auction System). 11. For purposes of complying with 47 CFR 1.2105(c), the Commission's rule prohibiting...

  7. 75 FR 61752 - Auction of FM Broadcast Construction Permits Scheduled for March 29, 2011; Comment Sought on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... COMMISSION Auction of FM Broadcast Construction Permits Scheduled for March 29, 2011; Comment Sought on... March 29, 2011 (Auction 91). This document also seeks comment on competitive bidding procedures for... March 29, 2011. II. Construction Permits In Auction 91 2. Auction 91 will offer 147 construction permits...

  8. Wave propagation in double walled carbon nanotubes by using doublet mechanics theory

    NASA Astrophysics Data System (ADS)

    Gul, Ufuk; Aydogdu, Metin

    2017-09-01

    Flexural and axial wave propagation in double walled carbon nanotubes embedded in an elastic medium and axial wave propagation in single walled carbon nanotubes are investigated. A length scale dependent theory which is called doublet mechanics is used in the analysis. Governing equations are obtained by using Hamilton principle. Doublet mechanics results are compared with classical elasticity and other size dependent continuum theories such as strain gradient theory, nonlocal theory and lattice dynamics. In addition, experimental wave frequencies of graphite are compared with the doublet mechanics theory. It is obtained that doublet mechanics gives accurate results for flexural and axial wave propagation in nanotubes. Thus, doublet mechanics can be used for the design of electro-mechanical nano-devices such as nanomotors, nanosensors and oscillators.

  9. Multi-unit auctions with budget-constrained bidders

    NASA Astrophysics Data System (ADS)

    Ghosh, Gagan Pratap

    In my dissertation, I investigate the effects of budget-constraints in multi-unit auctions. This is done in three parts. First, I analyze a case where all bidders have a common budget constraint. Precisely, I analyze an auction where two units of an object are sold at two simultaneous, sealed bid, first-price auctions, to bidders who have demand for both units. Bidders differ with respect to their valuations for the units. All bidders have an identical budget constraint which binds their ability to spend in the auction. I show that if valuation distribution is atom-less, then their does not exist any symmetric equilibrium in this auction game. In the second and third parts of my thesis, I analyze the sale of licenses for the right to drill for oil and natural gas in the Outer Continental Shelf (OCS) of the United States. These sales are conducted using simultaneous sealed-bid first-price auctions for multiple licenses, each representing a specific area (called a tract). Using aspects of observed bidding-behavior, I first make a prima facie case that bidders are budget-constrained in these auctions. In order to formalize this argument, I develop a simple extension of the standard model (where bidders differ in their valuations for the objects) by incorporating (random) budgets for the bidders. The auction-game then has a two-dimensional set of types for each player. I study the theoretical properties of this auction, assuming for simplicity that two units are being sold. I show that this game has an equilibrium in pure strategies that is symmetric with respect to the players and with respect to the units. The strategies are essentially pure in the sense that each bidder-type has a unique split (up to a permutation) of his budget between the two auctions. I then characterize the equilibrium in terms of the bid-distribution and iso-bid curves in the value-budget space. I derive various qualitative features of this equilibrium, among which are: (1) under mild

  10. Application for Single Price Auction Model (SPA) in AC Network

    NASA Astrophysics Data System (ADS)

    Wachi, Tsunehisa; Fukutome, Suguru; Chen, Luonan; Makino, Yoshinori; Koshimizu, Gentarou

    This paper aims to develop a single price auction model with AC transmission network, based on the principle of maximizing social surplus of electricity market. Specifically, we first formulate the auction market as a nonlinear optimization problem, which has almost the same form as the conventional optimal power flow problem, and then propose an algorithm to derive both market clearing price and trade volume of each player even for the case of market-splitting. As indicated in the paper, the proposed approach can be used not only for the price evaluation of auction or bidding market but also for analysis of bidding strategy, congestion effect and other constraints or factors. Several numerical examples are used to demonstrate effectiveness of our method.

  11. Mechanical properties and buckling behaviors of condensed double-walled carbon nanotubes.

    PubMed

    Zhang, Yingyan; Wang, Chien Ming; Tan, Vincent Beng Chye

    2009-08-01

    Molecular dynamics (MD) simulations are performed on condensed double-walled carbon nanotubes (CDWCNTs) to investigate the effects of compressed interwall spacings on their mechanical properties, in particular their buckling behavior under axial compression, torsion and bending. In CDWCNTs, the inner and outer nanotubes have diameters that are closer to each other than the nanotubes of conventional double-walled carbon nanotubes (DWCNTs). This leads to a smaller interwall spacing. The mechanical properties of the CDWCNTs, such as Young's modulus, interwall shear modulus, and the buckling strain under axial compression, torsion and bending are found to be greatly enhanced when compared with those of conventional DWCNTs. The enhancement is found to be inversely proportional to the interwall spacing.

  12. Mechanical reliability of double clad fibers in typical fiber laser deployment conditions

    NASA Astrophysics Data System (ADS)

    Walorny, Michael; Abramczyk, Jaroslaw; Jacobson, Nick; Tankala, Kanishka

    2016-03-01

    With the rapid acceptance of fiber lasers and amplifiers for various materials processing and defense applications the long term optical and mechanical reliability of the fiber laser, and therefore the components that make up the laser, is of significant interest to the industrial and defense communities. The double clad fiber used in a fiber laser is a key component whose lifetime in typical deployment conditions needs to be understood. The optical reliability of double clad fiber has recently been studied and a predictive model of fiber lifetime has been published. In contrast, a rigorous model for the mechanical reliability of the fiber and an analysis of the variables affecting the lifetime of the fiber in typical deployment conditions has not been studied. This paper uses the COST-218 model which is widely used for analyzing the mechanical lifetime of fiber used in the telecom industry. The factors affecting lifetime are analyzed to make the reader aware of the design choices a laser manufacturer can make, and the information they must seek from fiber suppliers, to ensure excellent lifetime for double clad fiber and consequently for the fiber laser. It is shown that the fiber's stress corrosion susceptibility, its proof strength, the coil diameter and the length of fiber coiled to achieve good beam quality all have important implications on fiber lifetime.

  13. [Arc spectrum diagnostic and heat coupling mechanism analysis of double wire pulsed MIG welding].

    PubMed

    Liu, Yong-qiang; Li, Huan; Yang, Li-jun; Zheng, Kai; Gao, Ying

    2015-01-01

    A double wire pulsed MIG welding test system was built in the present paper, in order to analyze the heat-coupling mechanism of double wire pulsed MIG welding, and study are temperature field. Spectroscopic technique was used in diagnostic analysis of the are, plasma radiation was collected by using hollow probe method to obtain the arc plasma optical signal The electron temperature of double wire pulsed MIG welding arc plasma was calculated by using Boltzmann diagram method, the electron temperature distribution was obtained, a comprehensive analysis of the arc was conducted combined with the high speed camera technology and acquisition means of electricity signal. The innovation of this paper is the combination of high-speed camera image information of are and optical signal of arc plasma to analyze the coupling mechanism for dual arc, and a more intuitive analysis for are temperature field was conducted. The test results showed that a push-pull output was achieved and droplet transfer mode was a drop in a pulse in the welding process; Two arcs attracted each other under the action of a magnetic field, and shifted to the center of the arc in welding process, so a new heat center was formed at the geometric center of the double arc, and flowing up phenomenon occurred on the arc; Dual arc electronic temperature showed an inverted V-shaped distribution overall, and at the geometric center of the double arc, the arc electron temperature at 3 mm off the workpiece surface was the highest, which was 16,887.66 K, about 4,900 K higher than the lowest temperature 11,963.63 K.

  14. Interpreting nonlinear vibrational spectroscopy with the classical mechanical analogs of double-sided Feynman diagrams.

    PubMed

    Noid, W G; Loring, Roger F

    2004-10-15

    Observables in coherent, multiple-pulse infrared spectroscopy may be computed from a vibrational nonlinear response function. This response function is conventionally calculated quantum-mechanically, but the challenges in applying quantum mechanics to large, anharmonic systems motivate the examination of classical mechanical vibrational nonlinear response functions. We present an approximate formulation of the classical mechanical third-order vibrational response function for an anharmonic solute oscillator interacting with a harmonic solvent, which establishes a clear connection between classical and quantum mechanical treatments. This formalism permits the identification of the classical mechanical analog of the pure dephasing of a quantum mechanical degree of freedom, and suggests the construction of classical mechanical analogs of the double-sided Feynman diagrams of quantum mechanics, which are widely applied to nonlinear spectroscopy. Application of a rotating wave approximation permits the analytic extraction of signals obeying particular spatial phase matching conditions from a classical-mechanical response function. Calculations of the third-order response function for an anharmonic oscillator coupled to a harmonic solvent are compared to numerically correct classical mechanical results.

  15. An Auctioning Reputation System Based on Anomaly Detection

    DTIC Science & Technology

    2005-01-01

    systems used by online auction houses do not address the concern of a buyer shopping for commodities—finding a good bargain. These systems do not provide...INTRODUCTION Online auction houses such as eBay have emerged as a conve- nient way to buy and sell items over the Internet. eBay alone has over 147 million...Pattern Classification. John Wiley and Sons, Inc., New York, NY, 2nd edition, 2000. [11] eBay Inc. Policy: Seller shill bidding. Published online at http

  16. Tilting double-prism scanner driven by cam-based mechanism.

    PubMed

    Li, Anhu; Yi, Wanli; Sun, Wansong; Liu, Liren

    2015-06-20

    A pair of orthogonal tilting prisms has been explored in our previous work to perform the orientation and position tracking function with tracking accuracy better than submicroradian order. Crucial to the function implementation, however, is the real-time nonlinear control of the tilting angles of double prisms for tracking a given target trajectory. In previous papers [Proc. SPIE5892, 1-5 (2005).PSISDG0277-786X; Appl. Opt.45, 8063 (2006).PSISDG0277-786X; Proc. SPIE6709, 41 (2007).PSISDG0277-786X; Appl. Opt.51, 356 (2011).10.1364/AO.51.000356APOPAI1559-128X; Appl. Opt.53, 3712 (2014).10.1364/AO.53.003712APOPAI1559-128X], a new driving method by a cam-based mechanism, which can transfer the control problem to the design of corresponding cam configuration, is investigated. The design process of a cam-based mechanism is explained from the mapping relation between the tilting angles of a prism and the configuration curve of a corresponding cam. Based on the designed cam-based mechanism, a tracking error less than 0.375% is depicted between the tracking trajectory and the original one. Moreover, the dynamic characteristic of the tracking mechanism is discussed in detail as well as the impacts of different tilting speeds on the tracking trajectory. The proposed tracking mechanism of a tilting double-prism scanner can create a new avenue for passively tracking a given target.

  17. Steady-state mechanical squeezing in a double-cavity optomechanical system

    PubMed Central

    Wang, Dong-Yang; Bai, Cheng-Hua; Wang, Hong-Fu; Zhu, Ai-Dong; Zhang, Shou

    2016-01-01

    We study the physical properties of double-cavity optomechanical system in which the mechanical resonator interacts with one of the coupled cavities and another cavity is used as an auxiliary cavity. The model can be expected to achieve the strong optomechanical coupling strength and overcome the optomechanical cavity decay, simultaneously. Through the coherent auxiliary cavity interferences, the steady-state squeezing of mechanical resonator can be generated in highly unresolved sideband regime. The validity of the scheme is assessed by numerical simulation and theoretical analysis of the steady-state variance of the mechanical displacement quadrature. The scheme provides a platform for the mechanical squeezing beyond the resolved sideband limit and solves the restricted experimental bounds at present. PMID:27917939

  18. A novel flexure-based microgripper with double amplification mechanisms for micro/nano manipulation

    NASA Astrophysics Data System (ADS)

    Sun, Xiantao; Chen, Weihai; Tian, Yanling; Fatikow, Sergej; Zhou, Rui; Zhang, Jianbin; Mikczinski, Manuel

    2013-08-01

    This paper describes the design, modeling, and testing of a novel flexure-based microgripper for a large jaw displacement with high resolution. Such a microgripper is indispensable in micro/nano manipulation. In achieving a large jaw displacement, double amplification mechanisms, namely, Scott-Russell mechanism and leverage mechanism arranged in series, are utilized to overcome the limited output of microgrippers driven by piezoelectric actuators. The mechanical performance of the microgripper is analyzed using the pseudo rigid body model approach. Finite element analysis is conducted to evaluate the performance and validate the established models for further optimum design of the microgripper. The prototype of the developed microgripper is fabricated, with which experimental tests are carried out. The experimental results show that the developed microgripper is capable of handling various sized micro-objects with a maximum jaw displacement of 134 μm and a high amplification ratio of 15.5.

  19. Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair.

    PubMed

    Ward, Jordan D; Muzzini, Diego M; Petalcorin, Mark I R; Martinez-Perez, Enrique; Martin, Julie S; Plevani, Paolo; Cassata, Giuseppe; Marini, Federica; Boulton, Simon J

    2010-01-29

    Homologous recombination (HR) is essential for repair of meiotic DNA double-strand breaks (DSBs). Although the mechanisms of RAD-51-DNA filament assembly and strand exchange are well characterized, the subsequent steps of HR are less well defined. Here, we describe a synthetic lethal interaction between the C. elegans helicase helq-1 and RAD-51 paralog rfs-1, which results in a block to meiotic DSB repair after strand invasion. Whereas RAD-51-ssDNA filaments assemble at meiotic DSBs with normal kinetics in helq-1, rfs-1 double mutants, persistence of RAD-51 foci and genetic interactions with rtel-1 suggest a failure to disassemble RAD-51 from strand invasion intermediates. Indeed, purified HELQ-1 and RFS-1 independently bind to and promote the disassembly of RAD-51 from double-stranded, but not single-stranded, DNA filaments via distinct mechanisms in vitro. These results indicate that two compensating activities are required to promote postsynaptic RAD-51 filament disassembly, which are collectively essential for completion of meiotic DSB repair.

  20. Mechanical and microstructural characterization of single and double pass Aluminum AA6061 friction stir weld joints

    NASA Astrophysics Data System (ADS)

    Othman, N. H.; Shah, L. H.; Ishak, M.

    2015-12-01

    This study focuses on the effect of single pass (SP), double sided pass (DSP) and normal double pass (NDP) method on friction stir welding of aluminum AA6061. Two pieces of AA6061 alloy with thickness of 6 mm were friction stir welded by using conventional milling machine. The rotational speeds that were used in this study were 800 rpm, 1000 rpm and 1200 rpm, respectively. The welding speed is fixed to 100 mm/min. Microstructure observation of welded area was studied by using optical microscope. Tensile test and Vickers hardness test were used to evaluate the mechanical properties of this specimen. Mechanical property analysis results indicate that at low rotational speeds, defects such as surface lack of fill and tunneling in the welded area can be observed. Vickers hardness of specimens however did not vary much when rotational speed is varied. Welded specimens using single pass method shows higher tensile strength and hardness value compared to both double pass methods up to 180.61 MPa. Moreover, DSP showed better tensile test and hardness test compared to NDP method. The optimum parameters were found to be single pass method with 1200 rpm of rotational speed. Therefore economically sound to only perform SP method to obtain maximum tensile strength for AA6061 FSW with thickness of 6 mm.

  1. Thermo-mechanical and experimental analysis of double pass line heating

    NASA Astrophysics Data System (ADS)

    Biswas, Pankaj; Mandal, N. R.; Sha, O. P.; Mahapatra, M. M.

    2011-06-01

    The present investigation deals with process analysis of oxy-acetylene flame assisted double pass line heating for varying plate thickness. oxy-acetylene flame as the heat source for multi pass line heating to achieve 3-D bending of plates with varying thicknesses was studied. The oxy-acetylene flame was modeled as the moving heat source in the FEM analysis. The transient thermal histories were predicted taking into account the temperature dependent thermo-mechanical properties. A comparative study between single pass and double pass line heating residual deformation was also carried out. The temperature distribution and residual deformations predicted by the numerical model developed in the present work compared fairly well with those of the experimental ones.

  2. Making Marketing Principles Tangible: Online Auctions as Living Case Studies

    ERIC Educational Resources Information Center

    Wood, Charles M.; Suter, Tracy A.

    2004-01-01

    This article presents an effective course supplement for Principles of Marketing classes. An experiential project involving online auctions is offered to instructors seeking to create a more participatory student environment and an interactive teaching style. A number of learning points are illustrated that allow instructors to use an auction…

  3. Predicting the Demand for Spectrum Allocation through Auctions (PREPRINT)

    DTIC Science & Technology

    2010-06-01

    part of new approach it is required to predict the customer needs . The customer needs will be predicted using automated collaborative filtering (ACF...the customer history, and bid for resources to meet customer needs . Dynamic spectrum allocation (DSA) using cognitive radios and DSA by auction

  4. Making Marketing Principles Tangible: Online Auctions as Living Case Studies

    ERIC Educational Resources Information Center

    Wood, Charles M.; Suter, Tracy A.

    2004-01-01

    This article presents an effective course supplement for Principles of Marketing classes. An experiential project involving online auctions is offered to instructors seeking to create a more participatory student environment and an interactive teaching style. A number of learning points are illustrated that allow instructors to use an auction…

  5. 15. Detail view of the original auction podium in the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Detail view of the original auction podium in the 1937 arena (main section), with the west bleachers at the left, the north bleachers at the right, and the monitor roof structure, supported by posts, above; looking northwest - Ewing Livestock Market, South side of First Avenue North, 500 feet west of Route 724, Ewing, Lee County, VA

  6. Understanding Persuasive Online Sales Messages from eBay Auctions

    ERIC Educational Resources Information Center

    White, Barbara Jo; Clapper, Danial; Noel, Rita; Fortier, Jenny; Grabolosa, Pierre

    2007-01-01

    Online auctions are dominated by eBay, which started bringing together buyers and sellers in 1995. eBay product listings can easily be used in business communication courses to better understand online sales messages. One great advantage is that the vast majority of nearly 15 million listings a day are written and assembled by everyday consumers…

  7. Teaching Auction Strategy Using Experiments Administered Via the Internet

    ERIC Educational Resources Information Center

    Asker, John; Grosskopf, Brit; McKinney, C. Nicholas; Niederle, Muriel; Roth, Alvin E.; Weizsacker, Georg

    2004-01-01

    The authors present an experimental design used to teach concepts in the economics of auctions and implications for e-Business procurement. The experiment is easily administered and can be adapted to many different treatments. The chief innovation is that it does not require the use of a lab or class time. Instead, the design can be implemented on…

  8. Empirical regularities of opening call auction in Chinese stock market

    NASA Astrophysics Data System (ADS)

    Gu, Gao-Feng; Ren, Fei; Ni, Xiao-Hui; Chen, Wei; Zhou, Wei-Xing

    2010-01-01

    We study the statistical regularities of an opening call auction using the ultra-high-frequency data of 22 liquid stocks traded on the Shenzhen Stock Exchange in 2003. The distribution of the relative price, defined as the relative difference between the order price in the opening call auction and the closing price on the last trading day, is asymmetric and that the distribution displays a sharp peak at the zero relative price and a relatively wide peak at the negative relative price. The detrended fluctuation analysis (DFA) method is adopted to investigate the long-term memory of relative order prices. We further study the statistical regularities of order sizes in the opening call auction, and observe a phenomenon of number preference, known as order size clustering. The probability density function (PDF) of order sizes could be well fitted by a q-Gamma function, and the long-term memory also exists in order sizes. In addition, both the average volume and the average number of orders decrease exponentially with the price level away from the best bid or ask price level in the limit-order book (LOB) established immediately after the opening call auction, and a price clustering phenomenon is observed.

  9. Understanding Persuasive Online Sales Messages from eBay Auctions

    ERIC Educational Resources Information Center

    White, Barbara Jo; Clapper, Danial; Noel, Rita; Fortier, Jenny; Grabolosa, Pierre

    2007-01-01

    Online auctions are dominated by eBay, which started bringing together buyers and sellers in 1995. eBay product listings can easily be used in business communication courses to better understand online sales messages. One great advantage is that the vast majority of nearly 15 million listings a day are written and assembled by everyday consumers…

  10. Disentangling the various Mechanisms of neutrinoless double beta decay to extract the neutrino mass

    NASA Astrophysics Data System (ADS)

    Vergados, J. D.

    2011-12-01

    It is well known that there exist many mechanisms that may contribute to neutrinoless double beta decay. By exploiting the fact that the associated nuclear matrix elements are target dependent we show that, given definite experimental results on a sufficient number of targets, one can determine or sufficiently constrain all lepton violating parameters including the mass term. As a specific example we show that, given the observation of the 0νββ-decay in three different nuclei, e.g. 76Ge, 100Mo and 130Te, and assuming just three active lepton number violating parameters, e.g. light and heavy neutrino mass mechanisms in left handed currents as well as R-parity breaking SUSY mechanism, one may determine all lepton violating parameters, provided that they are relatively real.

  11. Non-double-couple mechanisms of microearthquakes induced by hydraulic fracturing

    USGS Publications Warehouse

    Sileny, J.; Hill, D.P.; Eisner, L.; Cornet, F.H.

    2009-01-01

    We have inverted polarity and amplitude information of representative microearthquakes to investigate source mechanisms of seismicity induced by hydraulic fracturing in the Carthage Cotton Valley, east Texas, gas field. With vertical arrays of four and eight three-component geophones in two monitoring wells, respectively, we were able to reliably determine source mechanisms of the strongest events with the best signal-to-noise ratio. Our analysis indicates predominantly non-double-couple source mechanisms with positive volumetric component consistent with opening cracks oriented close to expected hydraulic fracture orientation. Our observations suggest the induced events are directly the result of opening cracks by fluid injection, in contrast to many previous studies where the seismicity is interpreted to be primarily shearing caused by pore pressure diffusion into the surrounding rock or associated with shear stresses created at the hydraulic fracture tip. Copyright 2009 by the American Geophysical Union.

  12. Disentangling the various Mechanisms of neutrinoless double beta decay to extract the neutrino mass

    SciTech Connect

    Vergados, J. D.

    2011-12-16

    It is well known that there exist many mechanisms that may contribute to neutrinoless double beta decay. By exploiting the fact that the associated nuclear matrix elements are target dependent we show that, given definite experimental results on a sufficient number of targets, one can determine or sufficiently constrain all lepton violating parameters including the mass term. As a specific example we show that, given the observation of the 0{nu}{beta}{beta}-decay in three different nuclei, e.g. {sup 76}Ge, {sup 100}Mo and {sup 130}Te, and assuming just three active lepton number violating parameters, e.g. light and heavy neutrino mass mechanisms in left handed currents as well as R-parity breaking SUSY mechanism, one may determine all lepton violating parameters, provided that they are relatively real.

  13. Kinetic-Dominated Charging Mechanism within Representative Aqueous Electrolyte-based Electric Double-Layer Capacitors.

    PubMed

    Yang, Huachao; Yang, Jinyuan; Bo, Zheng; Chen, Xia; Shuai, Xiaorui; Kong, Jing; Yan, Jianhua; Cen, Kefa

    2017-08-03

    The chemical nature of electrolytes has been demonstrated to play a pivotal role in the charge storage of electric double-layer capacitors (EDLCs), whereas primary mechanisms are still partially resolved but controversial. In this work, a systematic exploration into EDL structures and kinetics of representative aqueous electrolytes is performed with numerical simulation and experimental research. Unusually, a novel charging mechanism exclusively predominated by kinetics is recognized, going beyond traditional views of manipulating capacitances preferentially via interfacial structural variations. Specifically, strikingly distinctive EDL structures stimulated by diverse ion sizes, valences, and mixtures manifest a virtually identical EDL capacitance, where the dielectric nature of solvents attenuates ionic effects on electrolyte redistributions, in stark contradiction with solvent-free counterpart and traditional Helmholtz theory. Meanwhile, corresponding kinetics evolve conspicuously with ionic species, intimately correlated with ion-solvent interactions. The achieved mechanisms are subsequently illuminated by electrochemical measurements, highlighting the crucial interplay between ions and solvents in regulating EDLC performances.

  14. Mechanisms governing the interfacial delamination of thermal barrier coating system with double ceramic layers

    NASA Astrophysics Data System (ADS)

    Xu, Rong; Fan, Xueling; Wang, T. J.

    2016-05-01

    A systematic study of factors affecting the interfacial delamination of thermal barrier coating system (TBCs) with double ceramic layers (DCL) is presented. Crack driving forces for delaminations at two weak interfaces are examined. The results show that a thicker outermost ceramic layer can induce dramatic increase in crack driving force and make the interface between two ceramic coatings become more prone to delamination. The behavior is shown to be more prominent in TBCs with stiffer outmost coating. The thickness ratio of two ceramic layers is an important parameter for controlling the failure mechanisms and determining the lifetime of DCL TBCs under inservice condition. By accounting for the influences of thickness ratio of two ceramic layers and interfacial fracture toughnesses of two involved interfaces, the fracture mechanism map of DCL TBCs has been constructed, in which different failure mechanisms are identified. The results quanlitatively agree with the aviliable experimental data.

  15. Shock Wave Boundary Layer Interaction Mechanism on a Double Wedge Geometry

    NASA Astrophysics Data System (ADS)

    Celik, Bayram; Barada, Mohammad Adel El Hajj Ali; Durna, Ahmet Selim

    2015-11-01

    A hypersonic test series by Swantek & Austin report complex shock wave boundary layer interaction mechanisms and unsteady surface heat flux from a double wedge geometry in a low enthalpy Mach 7 flow. In order to understand the physics of the flow and the heat transfer, we study the flow computationally and compare the results for the double wedge geometries, whose second angle is higher and lower than the maximum deflection angle at Mach 7. Apart from the numbers of comprehensive computational studies on the subject available in open literature, our study aims to describe the flow physics by taking the influence of both boundary layers that are formed on the two walls of the wedge into account. In addition to describing the flow and heat transfer mechanisms, we investigate the time for the flows to reach steady state. We evaluate the interaction mechanisms in term of instant and time average surface heat flux distributions. We perform all computations using a finite volume based compressible Navier-Stokes solver, rhoCentralFoam, which is one of the several compressible flow solvers of an open source software, openFOAM.

  16. 78 FR 61350 - Tribal Mobility Fund Phase I Auction (Auction 902); Short-Form Application Filing Window...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ...-areas . The Bureaus are also making available geographic information system (GIS) data for the eligible... list of eligible areas for Auction 902. FOR FURTHER INFORMATION CONTACT: Wireless Telecommunications... and Governmental Affairs Bureau at (202) 418-0530 or (202) 418-0432 (TTY). SUPPLEMENTARY INFORMATION...

  17. Suppression mechanism of inter-tube transfer in double-wall carbon nanotubes

    NASA Astrophysics Data System (ADS)

    Uryu, Seiji

    2005-03-01

    Double-wall carbon nanotubes have incommensurate lattice structure and are quasi-periodic[1,2]. Therefore, inter-tube transfer of electrons between incommensurate tubes is the key to understanding of double-wall tubes. Although some theoretical studies reported suppression of inter-tube transfer in multiwall tubes[3], the mechanism has not been well understood. The purpose of this paper is to clarify effects of inter-tube transfer in double-wall tubes. Using a tight-binding model length-dependence of conductance due to inter-tube transfer is calculated. The conductance is negligibly small in comparison to the conductance quantum and oscillates around an average which is approximately independent of the length. It is revealed based on the first-order perturbation theory that the result is attributed to quasi-periodic oscillation of position dependence of small local effective inter-tube coupling. [1] M. Kociak, K. Suenaga, K. Hirahara, Y. Saito, T. Nakahira, and S. Iijima, Phys. Rev. Lett. 89 (2002) 155501. [2] J. M. Zuo, I. Vartanyants, M. Gao, R. Zhang, and L. A. Nagahara, Science 300 (2003) 1419. [3] Y.-G. Yoon, P. Delaney, and S. G. Louie, Phys. Rev. B 66 (2002) 073407.

  18. Generic mechanisms of decoherence of quantum oscillations in magnetic double-well systems

    NASA Astrophysics Data System (ADS)

    M. Chudnovsky, Eugene

    2004-05-01

    Fundamental conservation laws mandate parameter-free generic mechanisms of decoherence of quantum oscillations in double-well systems. We consider two examples: tunneling of the magnetic moment in nanomagnets and tunneling between macroscopic current states in SQUIDs. In both cases the decoherence occurs via emission of phonons and photons at the oscillation frequency. We also show that in a system of identical qubits the decoherence greatly increases due to the superradiance of electromagnetic and sound waves. Our findings have important implications for building elements of quantum computers based upon nanomagnets and SQUIDs.

  19. Bolted Double-Lap Composite Joints Under Mechanical and Thermal Loading

    NASA Technical Reports Server (NTRS)

    Kradinov, V.; Barut, A.; Madenci, E.; Walker, Sandra P. (Technical Monitor)

    2000-01-01

    This study concerns the determination of the contact stresses and contact region around bolt holes and the bolt load distribution in single- and double-lap joints of composite laminates with arbitrarily located bolts under general mechanical loading conditions and uniform temperature change. The unknown contact stress distribution and contact region between the bolt and laminates and the interaction among the bolts require the bolt load distribution, as well as the contact stresses, to be as part of the solution. The present method is based on the complex potential theory and the variational formulation in order to account for bolt stiffness, bolt-hole clearance, and finite geometry of the composite laminates.

  20. Revealing a double-inversion mechanism for the F⁻+CH₃Cl SN2 reaction.

    PubMed

    Szabó, István; Czakó, Gábor

    2015-01-19

    Stereo-specific reaction mechanisms play a fundamental role in chemistry. The back-side attack inversion and front-side attack retention pathways of the bimolecular nucleophilic substitution (SN2) reactions are the textbook examples for stereo-specific chemical processes. Here, we report an accurate global analytic potential energy surface (PES) for the F(-)+CH₃Cl SN2 reaction, which describes both the back-side and front-side attack substitution pathways as well as the proton-abstraction channel. Moreover, reaction dynamics simulations on this surface reveal a novel double-inversion mechanism, in which an abstraction-induced inversion via a FH···CH₂Cl(-) transition state is followed by a second inversion via the usual [F···CH₃···Cl](-) saddle point, thereby opening a lower energy reaction path for retention than the front-side attack. Quasi-classical trajectory computations for the F(-)+CH₃Cl(ν1=0, 1) reactions show that the front-side attack is a fast direct, whereas the double inversion is a slow indirect process.

  1. Non-double-couple earthquake mechanisms at the Hengill-Grensdalur volcanic complex, southwest Iceland

    USGS Publications Warehouse

    Julian, B.R.; Miller, A.D.; Foulger, G.R.

    1997-01-01

    The Hengill-Grensdalur area in Iceland generates frequent small non-double-couple earthquakes with explosive volumetric components. We collected high quality three-component digital recordings of 4,000 earthquakes on a purpose-designed, 32-station network in 1991, and determined focal mechanisms for 100 of the best-recorded earthquakes by inverting amplitude ratios. Many of the mechanisms are consistent, within the errors, with simultaneous shear and tensile faulting, with tensile faults parallel to the local spreading ridge, and shear faulting similar to that in the South Iceland transform-fault zone. Some events cannot be explained by this model, however, and require other processes, such as crack closing and partial compensation of tensile cracks by fluid flow.

  2. Auction development for the price-based electric power industry

    NASA Astrophysics Data System (ADS)

    Dekrajangpetch, Somgiat

    The restructuring of the electric power industry is to move away from the cost-based monopolistic environment of the past to the priced-based competitive environment. As the electric power industry is restructuring in many places, there are still many problems that need to be solved. The work in this dissertation contributes to solve some of the electric power auction problems. The majority of this work is aimed to help develop good markets. A LaGrangian relaxation (LR) Centralized Daily Commitment Auction (CDCA) has been implemented. It has been shown that the solution might not be optimal nor fair to some generation companies (GENCOs) when identical or similar generating units participate in a LR CDCA based auction. Supporting information for bidding strategies on how to change unit data to enhance the chances of bid acceptance has been developed. The majority of this work is based on Single Period Commodity Auction (SPCA). Alternative structures for the SPCA are outlined. Whether the optimal solution is degenerated is investigated. Good pricing criteria are summarized and the pricing method following good pricing criteria is developed. Electricity is generally considered as a homogeneous product. When availability level is used as additional characteristic to distinct electricity, electricity can be considered a heterogeneous product. The procedure to trade electricity as a heterogeneous product is developed. The SPCA is formulated as a linear program. The basic IPLP algorithm has been extended so that sensitivity analysis can be performed as in the simplex method. Sensitivity analysis is used to determine market reach. Additionally, sensitivity analysis is used in combination with the investigation of historical auction results to provide raw data for power system expansion. Market power is a critical issue in electric power deregulation. Firms with market power have an advantage over other competitor firms in terms of market reach. Various approaches to

  3. Design and Promotion Strategy of Marketing Platform of Aquatic Auction based on Internet

    NASA Astrophysics Data System (ADS)

    Peng, Jianliang

    For the online trade and promotion of aquatic products and related materials through the network between supply and demand, the design content and effective promotional strategies of aquatic auctions online marketing platform is proposed in this paper. Design elements involve the location of customer service, the basic function of the platform including the purchase of general orders, online auctions, information dissemination, and recommendation of fine products, human services, and payment preferences. Based on network and mobile e-commerce transaction support, the auction platform makes the transaction of aquatic products well in advance. The results are important practical value for the design and application of online marketing platform of aquatic auction.

  4. A GRAVITATIONAL DOUBLE-SCATTERING MECHANISM FOR GENERATING HIGH-VELOCITY OBJECTS DURING HALO MERGERS

    SciTech Connect

    Samsing, Johan

    2015-02-01

    We present a dynamical model that describes how halo particles can receive a significant energy kick from the merger between their own host halo and a target halo. This could provide a possible explanation for some high-velocity objects, including extended systems like globular clusters (GCs). In the model we especially introduce a double-scattering mechanism, where a halo particle receives a significant part of its total energy kick by first undergoing a gravitational deflection by the target halo and subsequently by its original host halo. This generates an energy kick that is due to the relative velocity between the halos during the deflections. We derive analytically the total kick energy of the particle, which is composed of energy from the double-scattering mechanism and tidal fields, as a function of its position in its original host halo just before merger. In the case of a 1:10 merger, we find that the presented mechanisms can easily generate particles with a velocity approximately two times the virial velocity of the target halo. This motivates us to suggest that the high velocity of the recently discovered GC HVGC-1 can be explained by a head-on halo merger. Finally, we illustrate the orbital evolution of high-velocity particles outside the virial sphere of the target halo by solving the equation of motion in an expanding universe. We find a sweet spot around a scale factor of 0.3-0.5 for ejecting particles into large orbits, which can easily reach beyond approximately five virial radii.

  5. A Gravitational Double-scattering Mechanism for Generating High-velocity Objects during Halo Mergers

    NASA Astrophysics Data System (ADS)

    Samsing, Johan

    2015-02-01

    We present a dynamical model that describes how halo particles can receive a significant energy kick from the merger between their own host halo and a target halo. This could provide a possible explanation for some high-velocity objects, including extended systems like globular clusters (GCs). In the model we especially introduce a double-scattering mechanism, where a halo particle receives a significant part of its total energy kick by first undergoing a gravitational deflection by the target halo and subsequently by its original host halo. This generates an energy kick that is due to the relative velocity between the halos during the deflections. We derive analytically the total kick energy of the particle, which is composed of energy from the double-scattering mechanism and tidal fields, as a function of its position in its original host halo just before merger. In the case of a 1:10 merger, we find that the presented mechanisms can easily generate particles with a velocity approximately two times the virial velocity of the target halo. This motivates us to suggest that the high velocity of the recently discovered GC HVGC-1 can be explained by a head-on halo merger. Finally, we illustrate the orbital evolution of high-velocity particles outside the virial sphere of the target halo by solving the equation of motion in an expanding universe. We find a sweet spot around a scale factor of 0.3-0.5 for ejecting particles into large orbits, which can easily reach beyond approximately five virial radii.

  6. Using auctions for contracting with hospitals when quality matters.

    PubMed

    Mougeot, Michel; Naegelen, Florence

    2003-03-01

    This paper analyzes the problem of contracting with hospitals with hidden information when the number of patients wanting treatment depends on the quality of health care services offered. The optimal policy is characterized in the case of a single hospital. It is demonstrated that the regulator can reduce the information rent by decreasing the quality. When the regulator is assumed to be able to organize an auction for awarding the right to provide the service, we characterize the optimal auction and the first score tendering procedure implementing it. The regulator can reimburse a unit price per treated patient and let the hospital choose the level of quality. It is proved that the expected quality of health care services is greater and the expected payment is lower than in the monopoly case.

  7. Determination of effective mechanical properties of a double-layer beam by means of a nano-electromechanical transducer

    SciTech Connect

    Hocke, Fredrik; Pernpeintner, Matthias; Gross, Rudolf; Zhou, Xiaoqing; Kippenberg, Tobias J.; Schliesser, Albert; Huebl, Hans

    2014-09-29

    We investigate the mechanical properties of a doubly clamped, double-layer nanobeam embedded into an electromechanical system. The nanobeam consists of a highly pre-stressed silicon nitride and a superconducting niobium layer. By measuring the mechanical displacement spectral density both in the linear and the nonlinear Duffing regime, we determine the pre-stress and the effective Young's modulus of the nanobeam. An analytical double-layer model quantitatively corroborates the measured values. This suggests that this model can be used to design mechanical multilayer systems for electro- and optomechanical devices, including materials controllable by external parameters such as piezoelectric, magnetostrictive, or in more general multiferroic materials.

  8. Dynamic Characteristics of Mechanical Ventilation System of Double Lungs with Bi-Level Positive Airway Pressure Model

    PubMed Central

    Shen, Dongkai; Zhang, Qian

    2016-01-01

    In recent studies on the dynamic characteristics of ventilation system, it was considered that human had only one lung, and the coupling effect of double lungs on the air flow can not be illustrated, which has been in regard to be vital to life support of patients. In this article, to illustrate coupling effect of double lungs on flow dynamics of mechanical ventilation system, a mathematical model of a mechanical ventilation system, which consists of double lungs and a bi-level positive airway pressure (BIPAP) controlled ventilator, was proposed. To verify the mathematical model, a prototype of BIPAP system with a double-lung simulators and a BIPAP ventilator was set up for experimental study. Lastly, the study on the influences of key parameters of BIPAP system on dynamic characteristics was carried out. The study can be referred to in the development of research on BIPAP ventilation treatment and real respiratory diagnostics. PMID:27660646

  9. Novel HCN sorbents based on layered double hydroxides: sorption mechanism and performance.

    PubMed

    Zhao, Qian; Tian, Senlin; Yan, Linxia; Zhang, Qiulin; Ning, Ping

    2015-03-21

    Layered double hydroxides (LDHs) and layered double oxides (LDOs) have been prepared and used as sorbents for hydrogen cyanide (HCN). Based on results from sorbent optimization experiments, the optimal performance for HCN removal was found in Ni-Al LDH. As evidenced by fixed-bed sorption studies, the Ni-Al LDO with the greatest surface area showed better performance and outperformed products calcined at 200, 400, or 500 °C, whereas, the Ni-Al LDH showed a more twofold higher sorption capacity than the Ni-Al LDO. Investigation of the mechanisms between HCN and sorbents reveals that the HCN removal by the Ni-Al LDH and Ni-Al LDO leads to the formation of the complex anion, [Ni(CN)4](2-). Nevertheless, the [Ni(CN)4](2-) can enter interlayer region of the Ni-Al LDH due to its anion exchangeability, which endows this LDH with more binding sites, not only on its external surfaces, but also on its internal surfaces located in the interlayer region. In contrast, [Ni(CN)4](2-) were only adsorbed on the external surface of the Ni-Al LDO. As a result, the sorption capacity of the Ni-Al LDH for HCN is twice as high as that of the Ni-Al LDO, which is at 21.55 mg/g.

  10. Improved Mechanical Compatibility and Cytocompatibility of Ta/Ti Double-Layered Composite Coating

    NASA Astrophysics Data System (ADS)

    Ding, Ding; Xie, Youtao; Li, Kai; Huang, Liping; Zheng, Xuebin

    2017-08-01

    In order to improve the mechanical compatibility and cytocompatibility of titanium implants, a composite coating with double layers composed of tantalum and titanium was designed and prepared using plasma spraying technology. In the composite coating, the upper tantalum layer provides a good biocompatibility, and the sublayer of titanium with a porous structure ensures the low elastic modulus. Results show that the fabricated composite coating exhibits a relatively low elastic modulus of 26.7 GPa, which is close to the elastic modulus of human cortical bone. In vitro cytocompatibility evaluation of the composite coating shows that the human bone marrow stromal cells exhibit enhanced adhesion and spreading performance on the double-layered composite coating in comparison with the single-layered titanium coating. In order to eliminate the misgivings of chemical stability of the composite coating in clinical application, electrochemical corrosion of the coating was examined. The results obtained revealed a very weak galvanic corrosion between the tantalum and titanium in the composite coating, which would ensure the safety of the coating in vivo.

  11. Improved Mechanical Compatibility and Cytocompatibility of Ta/Ti Double-Layered Composite Coating

    NASA Astrophysics Data System (ADS)

    Ding, Ding; Xie, Youtao; Li, Kai; Huang, Liping; Zheng, Xuebin

    2017-07-01

    In order to improve the mechanical compatibility and cytocompatibility of titanium implants, a composite coating with double layers composed of tantalum and titanium was designed and prepared using plasma spraying technology. In the composite coating, the upper tantalum layer provides a good biocompatibility, and the sublayer of titanium with a porous structure ensures the low elastic modulus. Results show that the fabricated composite coating exhibits a relatively low elastic modulus of 26.7 GPa, which is close to the elastic modulus of human cortical bone. In vitro cytocompatibility evaluation of the composite coating shows that the human bone marrow stromal cells exhibit enhanced adhesion and spreading performance on the double-layered composite coating in comparison with the single-layered titanium coating. In order to eliminate the misgivings of chemical stability of the composite coating in clinical application, electrochemical corrosion of the coating was examined. The results obtained revealed a very weak galvanic corrosion between the tantalum and titanium in the composite coating, which would ensure the safety of the coating in vivo.

  12. Forming mechanism of the bipolar resistance switching in double-layer memristive nanodevices.

    PubMed

    Lee, S B; Yoo, H K; Kim, K; Lee, J S; Kim, Y S; Sinn, S; Lee, D; Kang, B S; Kahng, B; Noh, T W

    2012-08-10

    To initiate resistance switching phenomena, it is usually necessary to apply a strong electric field to a sample. This forming process poses very serious obstacles in real nanodevice applications. In unipolar resistance switching (URS), it is well known that the forming originates from soft dielectric breakdown. However, the forming in bipolar resistance switching (BRS) is poorly understood. In this study, we investigated the forming processes in Pt/Ta₂O₅/TaOx/Pt and Pt/TaOx/Pt nanodevices, which showed BRS and URS, respectively. By comparing the double- and single-layer systems, we were able to observe differences in the BRS and URS forming processes. Using computer simulations based on an 'interface-modified random circuit breaker network model', we could explain most of our experimental observations. This success suggests that the BRS forming in our Pt/Ta₂O₅/TaOx/Pt double-layer system can occur via two processes, i.e., polarity-dependent resistance switching in the Ta₂O₅ layer and soft dielectric breakdown in the TaOx layer. This forming mechanism can be used to improve the performance of BRS devices. For example, we could improve the endurance properties of Pt/Ta₂O₅/TaOx/Pt cells by using a small forming voltage.

  13. 78 FR 2260 - Auction of FM Broadcast Construction Permits Rescheduled for April 23, 2013; Notice of Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS... Communications Commission. ACTION: Notice. SUMMARY: This document announces the auction of certain FM broadcast... all public notices pertaining to this auction. ii. Prohibited Communications and Compliance...

  14. Quantum Interactive Learning Tutorial on the Double-Slit Experiment to Improve Student Understanding of Quantum Mechanics

    ERIC Educational Resources Information Center

    Sayer, Ryan; Maries, Alexandru; Singh, Chandralekha

    2017-01-01

    Learning quantum mechanics is challenging, even for upper-level undergraduate and graduate students. Research-validated interactive tutorials that build on students' prior knowledge can be useful tools to enhance student learning. We have been investigating student difficulties with quantum mechanics pertaining to the double-slit experiment in…

  15. Structural Basis for Elastic Mechanical Properties of the DNA Double Helix

    PubMed Central

    Kim, Young-Joo; Kim, Do-Nyun

    2016-01-01

    In this article, we investigate the principal structural features of the DNA double helix and their effects on its elastic mechanical properties. We develop, in the pursuit of this purpose, a helical continuum model consisting of a soft helical core and two stiff ribbons wrapping around it. The proposed model can reproduce the negative twist-stretch coupling of the helix successfully as well as its global stretching, bending, and torsional rigidities measured experimentally. Our parametric study of the model using the finite element method further reveals that the stiffness of phosphate backbones is a crucial factor for the counterintuitive overwinding behavior of the duplex and its extraordinarily high torsional rigidity, the major-minor grooves augment the twist-stretch coupling, and the change of the helicity might be responsible for the transition from a negative to a positive twist-stretching coupling when a tensile force is applied to the duplex. PMID:27055239

  16. Ab initio bubble-driven denaturation of double-stranded DNA: Self-mechanical theory.

    PubMed

    Kuetche, Victor K

    2016-07-21

    Among the different theoretical models of the open-site-driven DNA-denaturation found in the literature, very few interests are actually paid to the fundamental unzipping process of the double-stranded DNA within the vicinity of its ground state condensate. In this paper, we address an alternative to better understand the process of denaturation of such a macromolecule by investigating the onset of its dynamics around its equilibrium state. We show that from the initiation of the transcription bubble by the promoter to the termination state, the open-states of the strands evolve dynamically while generating some localized waveguide channels with elastic scattering properties. We properly discuss the nonlinear dynamics of these structures within the viewpoint of the self-mechanical theory while inferring to the physical structure of the findings and their potential issues. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. [Plasma temperature calculation and coupling mechanism analysis of laser-double wire hybrid welding].

    PubMed

    Zheng, Kai; Li, Huan; Yang, Li-Jun; Gu, Xiao-Yan; Gao, Ying

    2013-04-01

    The plasma radiation of laser-double wire hybrid welding was collected by using fiber spectrometer, the coupling mechanism of arc with laser was studied through high-speed photography during welding process, and the temperature of hybrid plasma was calculated by using the method of Boltzmann plot. The results indicated that with laser hybrid, luminance was enhanced; radiation intensity became stronger; arc was attracted to the laser point; cross section contracted and arc was more stable. The laser power, welding current and arc-arc distance are important factors that have great influence on electron temperature. Increase in the laser power, amplification of welding current and reduction of arc-arc distance can all result in the rise of temperature.

  18. DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair.

    PubMed

    Sibanda, Bancinyane L; Chirgadze, Dimitri Y; Ascher, David B; Blundell, Tom L

    2017-02-03

    DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a central component of nonhomologous end joining (NHEJ), repairing DNA double-strand breaks that would otherwise lead to apoptosis or cancer. We have solved its structure in complex with the C-terminal peptide of Ku80 at 4.3 angstrom resolution using x-ray crystallography. We show that the 4128-amino acid structure comprises three large structural units: the N-terminal unit, the Circular Cradle, and the Head. Conformational differences between the two molecules in the asymmetric unit are correlated with changes in accessibility of the kinase active site, which are consistent with an allosteric mechanism to bring about kinase activation. The location of KU80ct194 in the vicinity of the breast cancer 1 (BRCA1) binding site suggests competition with BRCA1, leading to pathway selection between NHEJ and homologous recombination.

  19. An experimental study of double-peeling mechanism inspired by biological adhesive systems

    NASA Astrophysics Data System (ADS)

    Heepe, Lars; Raguseo, Saverio; Gorb, Stanislav N.

    2017-02-01

    Double- (or multiple-) peeling systems consist of two (or numerous) tapes adhering to a substrate and having a common hinge, where the pulling force is applied. Biological systems, consisting of tape-like (or spatula-like) contact elements, are widely observed in adhesive pads of flies, beetles, spiders, and geckos. It was previously hypothesized and analytically modeled that the simultaneous use of two or more such tape-like contacts in the opposite movement of contralateral legs during ceiling locomotion leads to enhanced, robust, and stable overall attachment, if compared to independently working contact points. In this paper, this biological solution for smart adhesion is demonstrated in an experiment using elastic adhesive tapes. The obtained results not only aided in explaining the functional mechanism of biological adhesive systems, but also in providing an experimental proof for biological observations and previous theoretical models.

  20. Double negative elastic metamaterial design through electrical-mechanical circuit analogies.

    PubMed

    Pope, Simon A

    2013-07-01

    Previous studies into solid elastic metamaterials which have a simultaneously negative effective bulk modulus and density have proposed designs for materials with relatively narrow bandwidths, because of the reliance on resonators to provide the dispersive material properties. Some of the proposed novel applications for metamaterials, such as invisibility cloaks and sub-wavelength lenses, generally require materials with inherently larger bandwidths for practical exploitation. In this paper, a well-known electromagnetic metamaterial design is used together with the electrical-mechanical circuit analogies to propose a simultaneously double negative elastic metamaterial design which does not suffer from the narrow bandwidth constraints of previous designs. An interesting consequence of the proposed design is that it has an effective wavelength which asymptotically goes to infinity with frequency.

  1. Structural Basis for Elastic Mechanical Properties of the DNA Double Helix.

    PubMed

    Kim, Young-Joo; Kim, Do-Nyun

    2016-01-01

    In this article, we investigate the principal structural features of the DNA double helix and their effects on its elastic mechanical properties. We develop, in the pursuit of this purpose, a helical continuum model consisting of a soft helical core and two stiff ribbons wrapping around it. The proposed model can reproduce the negative twist-stretch coupling of the helix successfully as well as its global stretching, bending, and torsional rigidities measured experimentally. Our parametric study of the model using the finite element method further reveals that the stiffness of phosphate backbones is a crucial factor for the counterintuitive overwinding behavior of the duplex and its extraordinarily high torsional rigidity, the major-minor grooves augment the twist-stretch coupling, and the change of the helicity might be responsible for the transition from a negative to a positive twist-stretching coupling when a tensile force is applied to the duplex.

  2. Nonmetallic rigid-flexible outer sheath with pneumatic shapelocking mechanism and double curvature structure.

    PubMed

    Zuo, Siyang; Masamune, Ken; Kuwana, Kenta; Tomikawa, Morimasa; Ieiri, Satoshi; Ohdaira, Takeshi; Hashizume, Makoto; Dohi, Takeyoshi

    2011-01-01

    Single port access (SPA) surgery is a laparoscopic procedure using only one transumbilical-placed port. Natural orifice transluminal endoscopic surgery (NOTES) offers the possibility of surgery without visible scars. To address the access and stability problems in SPA and NOTES, we developed a device called rigid-flexible outer sheath. This sheath can be switched between flexible and rigid modes by a novel pneumatic shapelocking mechanism, and it has a double curvature structure that enables it to flex in four directions at the distal end and three directions on the rigid-flexible shaft. The insertion part of the prototype is 300 mm long with a 20 mm outer diameter, and the part is equipped with four working channels. In vivo experiments using a swine show that the outer sheath has high potential for solving access and stability problems. We expect that the outer sheath will be useful for SPA and NOTES.

  3. Dense surface seismic data confirm non-double-couple source mechanisms induced by hydraulic fracturing

    USGS Publications Warehouse

    Pesicek, Jeremy; Cieślik, Konrad; Lambert, Marc-André; Carrillo, Pedro; Birkelo, Brad

    2016-01-01

    We have determined source mechanisms for nine high-quality microseismic events induced during hydraulic fracturing of the Montney Shale in Canada. Seismic data were recorded using a dense regularly spaced grid of sensors at the surface. The design and geometry of the survey are such that the recorded P-wave amplitudes essentially map the upper focal hemisphere, allowing the source mechanism to be interpreted directly from the data. Given the inherent difficulties of computing reliable moment tensors (MTs) from high-frequency microseismic data, the surface amplitude and polarity maps provide important additional confirmation of the source mechanisms. This is especially critical when interpreting non-shear source processes, which are notoriously susceptible to artifacts due to incomplete or inaccurate source modeling. We have found that most of the nine events contain significant non-double-couple (DC) components, as evident in the surface amplitude data and the resulting MT models. Furthermore, we found that source models that are constrained to be purely shear do not explain the data for most events. Thus, even though non-DC components of MTs can often be attributed to modeling artifacts, we argue that they are required by the data in some cases, and can be reliably computed and confidently interpreted under favorable conditions.

  4. Double-ionization mechanisms of the argon dimer in intense laser fields

    SciTech Connect

    Ulrich, B.; Vredenborg, A.; Malakzadeh, A.; Meckel, M.; Cole, K.; Jahnke, T.; Doerner, R.; Smolarski, M.; Chang, Z.

    2010-07-15

    We have measured the two-site double ionization of argon dimers by ultrashort laser pulses leading to fragmentation into two singly charged argon ions. Contrary to the expectations from a pure Coulomb explosion following rapid removal of one electron from each of the atoms, we find three distinct peaks in the kinetic energy release (KER) distribution. By measuring the angular distribution of the fragment ions and the vector momentum of one of the emitted electrons for circular and linear laser polarization, we are able to unravel the ionization mechanisms leading to the three features in the KER. The most abundant one results from tunnel ionization at one site followed by charge-enhanced tunnel ionization of the second atom. The second mechanism, which leads to a higher KER we identify as sequential tunnel ionization of both atoms accompanied by excitation. The third mechanism is present with linearly polarized light only. It is most likely a frustrated triple ionization, where the third electron does not escape but is trapped in a Rydberg state.

  5. Classical and quantum-mechanical treatments of nonsequential double ionization with few-cycle laser pulses

    NASA Astrophysics Data System (ADS)

    Figueira de Morisson Faria, C.; Liu, X.; Sanpera, A.; Lewenstein, M.

    2004-10-01

    We address nonsequential double ionization induced by strong, linearly polarized laser fields of only a few cycles, considering a physical mechanism in which the second electron is dislodged by the inelastic collision of the first electron with its parent ion. The problem is treated classically, using an ensemble model, and quantum mechanically, within the strong-field and uniform saddle-point approximations. In the latter case, the results are interpreted in terms of “quantum orbits,” which can be related to the trajectories of a classical electron in an electric field. We obtain highly asymmetric electron momentum distributions, which strongly depend on the absolute phase, i.e., on the phase difference between the pulse envelope and its carrier frequency. Around a particular value of this parameter, the distributions shift from the region of positive to that of negative momenta, or vice versa, in a radical fashion. This behavior is investigated in detail for several driving-field parameters, and provides a very efficient method for measuring the absolute phase. Both models yield very similar distributions, which share the same physical explanation. There exist, however, minor discrepancies due to the fact that, beyond the region for which electron-impact ionization is classically allowed, the yields from the quantum-mechanical computation decay exponentially, whereas their classical counterparts vanish.

  6. A new, double-inversion mechanism of the F(-) + CH3Cl SN2 reaction in aqueous solution.

    PubMed

    Liu, Peng; Wang, Dunyou; Xu, Yulong

    2016-11-23

    Atomic-level, bimolecular nucleophilic substitution reaction mechanisms have been studied mostly in the gas phase, but the gas-phase results cannot be expected to reliably describe condensed-phase chemistry. As a novel, double-inversion mechanism has just been found for the F(-) + CH3Cl SN2 reaction in the gas phase [Nat. Commun., 2015, 6, 5972], here, using multi-level quantum mechanics methods combined with the molecular mechanics method, we discovered a new, double-inversion mechanism for this reaction in aqueous solution. However, the structures of the stationary points along the reaction path show significant differences from those in the gas phase due to the strong influence of solvent and solute interactions, especially due to the hydrogen bonds formed between the solute and the solvent. More importantly, the relationship between the two double-inversion transition states is not clear in the gas phase, but, here we revealed a novel intermediate complex serving as a "connecting link" between the two transition states of the abstraction-induced inversion and the Walden-inversion mechanisms. A detailed reaction path was constructed to show the atomic-level evolution of this novel double reaction mechanism in aqueous solution. The potentials of mean force were calculated and the obtained Walden-inversion barrier height agrees well with the available experimental value.

  7. Insect-like flapping wing mechanism based on a double spherical Scotch yoke

    PubMed Central

    Galiński, Cezary; Żbikowski, Rafał

    2005-01-01

    We describe the rationale, concept, design and implementation of a fixed-motion (non-adjustable) mechanism for insect-like flapping wing micro air vehicles in hover, inspired by two-winged flies (Diptera). This spatial (as opposed to planar) mechanism is based on the novel idea of a double spherical Scotch yoke. The mechanism was constructed for two main purposes: (i) as a test bed for aeromechanical research on hover in flapping flight, and (ii) as a precursor design for a future flapping wing micro air vehicle. Insects fly by oscillating (plunging) and rotating (pitching) their wings through large angles, while sweeping them forwards and backwards. During this motion the wing tip approximately traces a ‘figure-of-eight’ or a ‘banana’ and the wing changes the angle of attack (pitching) significantly. The kinematic and aerodynamic data from free-flying insects are sparse and uncertain, and it is not clear what aerodynamic consequences different wing motions have. Since acquiring the necessary kinematic and dynamic data from biological experiments remains a challenge, a synthetic, controlled study of insect-like flapping is not only of engineering value, but also of biological relevance. Micro air vehicles are defined as flying vehicles approximately 150 mm in size (hand-held), weighing 50–100 g, and are developed to reconnoitre in confined spaces (inside buildings, tunnels, etc.). For this application, insect-like flapping wings are an attractive solution and hence the need to realize the functionality of insect flight by engineering means. Since the semi-span of the insect wing is constant, the kinematics are spatial; in fact, an approximate figure-of-eight/banana is traced on a sphere. Hence a natural mechanism implementing such kinematics should be (i) spherical and (ii) generate mathematically convenient curves expressing the figure-of-eight/banana shape. The double spherical Scotch yoke design has property (i) by definition and achieves (ii) by

  8. 47 CFR 27.1213 - Designated entity provisions for BRS in Commission auctions commencing prior to January 1, 2004.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Commission auctions commencing prior to January 1, 2004. (a) Eligibility for small business provisions. For purposes of Commission auctions commencing prior to January 1, 2004 for BRS licenses, a small business is..., 2004 for BTA service areas are eligible for special incentives in the auction process. See 47 CFR...

  9. 47 CFR 27.1213 - Designated entity provisions for BRS in Commission auctions commencing prior to January 1, 2004.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Commission auctions commencing prior to January 1, 2004. (a) Eligibility for small business provisions. For purposes of Commission auctions commencing prior to January 1, 2004 for BRS licenses, a small business is..., 2004 for BTA service areas are eligible for special incentives in the auction process. See 47 CFR...

  10. 75 FR 8703 - Auction of Lower and Upper Paging Bands Licenses Scheduled for May 25, 2010; Notice and Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... licensees to use certain portions of the electromagnetic spectrum or provide service to certain areas in... INFORMATION CONTACT: Wireless Telecommunications Bureau, Auctions and Spectrum Access Division: For legal... the upcoming auction of 9,603 licenses for lower and upper paging bands spectrum. This auction,...

  11. 78 FR 24404 - Auction of Lower and Upper Paging Band Licenses Scheduled for July 16, 2013; Notice of Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-25

    ... licensees to use certain portions of the electromagnetic spectrum or provide service to certain areas in... Spectrum Access Division: For legal and general auction questions: Howard Davenport (attorney) at (202) 418... lower and upper ] paging bands spectrum. This auction, which is designated as Auction 95, is...

  12. 7 CFR 29.75b - Display of baled flue-cured tobacco on auction warehouse floors in designated markets.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Display of baled flue-cured tobacco on auction... Inspection § 29.75b Display of baled flue-cured tobacco on auction warehouse floors in designated markets. Each lot of baled flue-cured tobacco displayed for sale on auction warehouse floors shall have...

  13. 29 CFR 516.13 - Livestock auction employees exempt from overtime pay requirements under section 13(b)(13) of the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Livestock auction employees exempt from overtime pay....13 Livestock auction employees exempt from overtime pay requirements under section 13(b)(13) of the... employee is employed both in agriculture and in connection with livestock auction operations: (a) The...

  14. 77 FR 60690 - Auction of FM Broadcast Construction Permits Scheduled for March 26, 2013; Comment Sought on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-04

    ... amounts. Under this proposal, the FCC Auction System interface will list the acceptable bid amounts for... on the Commission's Electronic Comment Filing System (ECFS) Web page at http://www.fcc.gov/cgb/ecfs... Auction System (FCC Auction System). Bidders will also have the option of placing bids by...

  15. 76 FR 60830 - Auction of FM Broadcast Construction Permits Scheduled for March 27, 2012; Comment Sought on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... COMMISSION Auction of FM Broadcast Construction Permits Scheduled for March 27, 2012; Comment Sought on... commence on March 27, 2012. This document also seeks comment on competitive bidding procedures for this... used for this auction. This auction is scheduled to commence on March 27, 2012, and is designated as...

  16. 78 FR 11179 - Auction of Lower and Upper Paging Bands Licenses Scheduled for July 16, 2013; Comment Sought on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ..., please provide the appropriate FCC document number, for example, DA 13-60. The Auction 95 Comment Public... in Auction 95. Due to the large number of licenses in Auction 95, the complete list of licenses... that the lower band licenses should be awarded in each of the 175 geographic areas known as Economic...

  17. Genetic mechanisms of allopolyploid speciation through hybrid genome doubling: novel insights from wheat (Triticum and Aegilops) studies.

    PubMed

    Matsuoka, Yoshihiro; Takumi, Shigeo; Nasuda, Shuhei

    2014-01-01

    Polyploidy, which arises through complex genetic and ecological processes, is an important mode of plant speciation. This review provides an overview of recent advances in understanding why plant polyploid species are so ubiquitous and diverse. We consider how the modern framework for understanding genetic mechanisms of speciation could be used to study allopolyploid speciation that occurs through hybrid genome doubling, that is, whole genome doubling of interspecific F1 hybrids by the union of male and female unreduced gametes. We outline genetic and ecological mechanisms that may have positive or negative impacts on the process of allopolyploid speciation through hybrid genome doubling. We also discuss the current status of studies on the underlying genetic mechanisms focusing on the wheat (Triticum and Aegilops) hybrid-specific reproductive phenomena that are well known but deserve renewed attention from an evolutionary viewpoint.

  18. Sold! The Elementary Classroom Auction as Learning Tool of Communication and Economics

    ERIC Educational Resources Information Center

    Boyd, Josh; Boyd, Gina

    2014-01-01

    An auction, though an economic tool, is essentially a performance dependent on communication (Smith, 1989). The auctioneer dictates the pace, asks for bids, and acknowledges responses; the enterprise is controlled by a voice (Boyce, 2001). Bidders must listen and respond strategically to the communication of the people around them. An auction…

  19. 29 CFR 780.620 - Minimum wage for livestock auction work.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Minimum wage for livestock auction work. 780.620 Section 780.620 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR... for Exemption § 780.620 Minimum wage for livestock auction work. The application of the exemption is...

  20. Sold! The Elementary Classroom Auction as Learning Tool of Communication and Economics

    ERIC Educational Resources Information Center

    Boyd, Josh; Boyd, Gina

    2014-01-01

    An auction, though an economic tool, is essentially a performance dependent on communication (Smith, 1989). The auctioneer dictates the pace, asks for bids, and acknowledges responses; the enterprise is controlled by a voice (Boyce, 2001). Bidders must listen and respond strategically to the communication of the people around them. An auction…

  1. 9 CFR 2.76 - Records: Operators of auction sales and brokers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Records: Operators of auction sales and brokers. 2.76 Section 2.76 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Records § 2.76 Records: Operators of auction sales and...

  2. 9 CFR 2.76 - Records: Operators of auction sales and brokers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Records: Operators of auction sales and brokers. 2.76 Section 2.76 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Records § 2.76 Records: Operators of auction sales and...

  3. 9 CFR 2.76 - Records: Operators of auction sales and brokers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Records: Operators of auction sales and brokers. 2.76 Section 2.76 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Records § 2.76 Records: Operators of auction sales and...

  4. 9 CFR 2.76 - Records: Operators of auction sales and brokers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Records: Operators of auction sales and brokers. 2.76 Section 2.76 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Records § 2.76 Records: Operators of auction sales and...

  5. 29 CFR 780.620 - Minimum wage for livestock auction work.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Minimum wage for livestock auction work. 780.620 Section 780.620 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR... for Exemption § 780.620 Minimum wage for livestock auction work. The application of the exemption is...

  6. 29 CFR 780.620 - Minimum wage for livestock auction work.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Minimum wage for livestock auction work. 780.620 Section 780.620 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR... for Exemption § 780.620 Minimum wage for livestock auction work. The application of the exemption is...

  7. 29 CFR 780.620 - Minimum wage for livestock auction work.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Minimum wage for livestock auction work. 780.620 Section 780.620 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR... for Exemption § 780.620 Minimum wage for livestock auction work. The application of the exemption is...

  8. 29 CFR 780.620 - Minimum wage for livestock auction work.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Minimum wage for livestock auction work. 780.620 Section 780.620 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR... for Exemption § 780.620 Minimum wage for livestock auction work. The application of the exemption is...

  9. 31 CFR 356.22 - Does the Treasury have any limitations on auction awards?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Does the Treasury have any limitations on auction awards? 356.22 Section 356.22 Money and Finance: Treasury Regulations Relating to Money..., PUBLIC DEBT SERIES NO. 1-93) Determination of Auction Awards; Settlement § 356.22 Does the Treasury...

  10. Are Structural Estimates of Auction Models Reasonable? Evidence from Experimental Data

    ERIC Educational Resources Information Center

    Bajari, Patrick; Hortacsu, Ali

    2005-01-01

    Recently, economists have developed methods for structural estimation of auction models. Many researchers object to these methods because they find the strict rationality assumptions to be implausible. Using bid data from first-price auction experiments, we estimate four alternative structural models: (1) risk-neutral Bayes-Nash, (2) risk-averse…

  11. Comment on "Cryptanalysis and improvement of the secure quantum sealed-bid auction with post confirmation"

    NASA Astrophysics Data System (ADS)

    Zhao, Zhangji; Wang, Weijia

    2014-11-01

    In a recent paper, an improvement of quantum sealed-bid auction protocol is proposed by introducing hash function. However, in this comment, it is shown that the improvement brings in other problems which would not complete the task of a sealed-bid auction fairly.

  12. 77 FR 38061 - Mobility Fund Phase I Auction Supplemental Short-Form Instructions and Other Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... Phase I Auction for completing FCC Form 180, announce the availability of certain updated files and..., please provide the appropriate FCC document number, for example, DA 12-947. The Supplemental Filing... site: http://wireless.fcc.gov/auctions/901/ or by using the search function for AU Docket No. 12-25...

  13. Robust Multi-unit Auction Protocol against False-name Bids

    NASA Astrophysics Data System (ADS)

    Yokoo, Makoto; Sakurai, Yuko; Matsubara, Shigeo

    This paper presents a new multi-unit auction protocol (IR protocol) that is robust against false-name bids. Internet auctions have become an integral part of Electronic Commerce and a promising field for applying agent and Artificial Intelligence technologies. Although the Internet provides an excellent infrastructure for executing auctions, the possibility of a new type of cheating called false-name bids has been pointed out. A false-name bid is a bid submitted under a fictitious name. A protocol called LDS has been developed for combinatorial auctions of multiple different items and has proven to be robust against false-name bids. Although we can modify the LDS protocol to handle multi-unit auctions, in which multiple units of an identical item are auctioned, the protocol is complicated and requires the auctioneer to carefully pre-determine the combination of bundles to obtain a high social surplus or revenue. For the auctioneer, our newly developed IR protocol is easier to use than the LDS, since the combination of bundles is automatically determined in a flexible manner according to the declared evaluation values of agents. The evaluation results show that the IR protocol can obtain a better social surplus than that obtained by the LDS protocol.

  14. 29 CFR 780.619 - Work “in connection with” livestock auction operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Work âin connection withâ livestock auction operations. 780... FAIR LABOR STANDARDS ACT Employment in Agriculture and Livestock Auction Operations Under the Section 13(b)(13) Exemption Requirements for Exemption § 780.619 Work “in connection with” livestock...

  15. Are Structural Estimates of Auction Models Reasonable? Evidence from Experimental Data

    ERIC Educational Resources Information Center

    Bajari, Patrick; Hortacsu, Ali

    2005-01-01

    Recently, economists have developed methods for structural estimation of auction models. Many researchers object to these methods because they find the strict rationality assumptions to be implausible. Using bid data from first-price auction experiments, we estimate four alternative structural models: (1) risk-neutral Bayes-Nash, (2) risk-averse…

  16. 30 CFR 585.220 - What auction format may BOEM use in a lease sale?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Issuance of OCS Renewable Energy Leases Competitive Lease Award Process § 585.220 What auction format may... award renewable energy leases and will use one of the following auction formats, as determined...

  17. 30 CFR 585.220 - What auction format may BOEM use in a lease sale?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Issuance of OCS Renewable Energy Leases Competitive Lease Award Process § 585.220 What auction format may... award renewable energy leases and will use one of the following auction formats, as determined...

  18. 30 CFR 585.220 - What auction format may BOEM use in a lease sale?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Issuance of OCS Renewable Energy Leases Competitive Lease Award Process § 585.220 What auction format may... award renewable energy leases and will use one of the following auction formats, as determined...

  19. 30 CFR 285.220 - What auction format may MMS use in a lease sale?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Issuance of OCS Renewable Energy Leases Competitive Lease Award Process § 285... competitive auctions to award renewable energy leases and will use one of the following auction formats,...

  20. Theoretical study on the mechanism of double proton transfer in porphycene by path-integral molecular dynamics simulations

    NASA Astrophysics Data System (ADS)

    Yoshikawa, Takehiro; Sugawara, Shuichi; Takayanagi, Toshiyuki; Shiga, Motoyuki; Tachikawa, Masanori

    2010-08-01

    Full-dimensional path-integral molecular dynamics simulations were performed to determine whether the double proton transfer tautomerization of porphycene is a concerted or a stepwise process. We employed an on-the-fly direct dynamics technique at the semiempirical PM6 method whose parameters were determined so as that the relative energies of the stationary points approximately reproduce previously reported electronic structure calculations. It was found that double proton transfer occurs dominantly through the concerted pathway via the second-order saddle point structure and that contribution of the stepwise mechanism increases with a temperature increase. Nuclear quantum effects play essential roles in determining the proton transfer mechanism.

  1. 78 FR 45524 - Auction of H Block Licenses in the 1915-1920 MHz and 1995-2000 MHz Bands; Comment Sought on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    .... SUMMARY: This document announces the intention to hold an auction of H Block licenses in the 1915-1920 and... INFORMATION CONTACT: Wireless Telecommunications Bureau, Auctions and Spectrum Access Division: For auction... INFORMATION: This is a summary of the Auction 96 Comment Public Notice released on July 15, 2013. The complete...

  2. Telomere Dysfunction Triggers Palindrome Formation Independently of Double-Strand Break Repair Mechanisms

    PubMed Central

    Raykov, Vasil; Marvin, Marcus E.; Louis, Edward J.; Maringele, Laura

    2016-01-01

    Inverted chromosome duplications or palindromes are linked with genetic disorders and malignant transformation. They are considered by-products of DNA double-strand break (DSB) repair: the homologous recombination (HR) and the nonhomologous end joining (NHEJ). Palindromes near chromosome ends are often triggered by telomere losses. An important question is to what extent their formation depends upon DSB repair mechanisms. Here we addressed this question using yeast genetics and comparative genomic hybridization. We induced palindrome formation by passaging cells lacking any form of telomere maintenance (telomerase and telomere recombination). Surprisingly, we found that DNA ligase 4, essential for NHEJ, did not make a significant contribution to palindrome formation induced by telomere losses. Moreover RAD51, important for certain HR-derived mechanisms, had little effect. Furthermore RAD52, which is essential for HR in yeast, appeared to decrease the number of palindromes in cells proliferating without telomeres. This study also uncovered an important role for Rev3 and Rev7 (but not for Pol32) subunits of polymerase ζ in the survival of cells undergoing telomere losses and forming palindromes. We propose a model called short-inverted repeat-induced synthesis in which DNA synthesis, rather than DSB repair, drives the inverted duplication triggered by telomere dysfunction. PMID:27334270

  3. Characterization and mechanism of glass microwelding by double-pulse ultrafast laser irradiation.

    PubMed

    Wu, Sizhu; Wu, Dong; Xu, Jian; Hanada, Yasutaka; Suganuma, Ryo; Wang, Haiyu; Makimura, Testuya; Sugioka, Koji; Midorikawa, Katsumi

    2012-12-17

    We investigated the physical mechanism of high-efficiency glass microwelding by double-pulse ultrafast laser irradiation by measuring the dependences of the size of the heat-affected zone and the bonding strength on the delay time between the two pulses for delay time up to 80 ns. The size of the heat-affected zone increases rapidly when the delay time is increased from 0 to 12.5 ps. It then decreases dramatically when the delay time is further increased to 30 ps. It has a small peak around 100 ps. For delay time up to 40 ns, the size of the heat-affected zone exceeds that for a delay time of 0 ps, whereas for delay time over 60 ps, it becomes smaller than that for a delay time of 0 ps. The bonding strength exhibits the same tendency. The underlying physical mechanism is discussed in terms of initial electron excitation by the first pulse and subsequent excitation by the second pulse: specifically, the first pulse induces multiphoton ionization or tunneling ionization, while the second pulse induces electron heating or avalanche ionization or the second pulse is absorbed by the localized state. Transient absorption of glass induced by the ultrafast laser pulse was analyzed by an ultrafast pump-probe technique. We found that the optimum pulse energy ratio is unity. These results provide new insights into high-efficiency ultrafast laser microwelding of glass and suggest new possibilities for further development of other ultrafast laser processing techniques.

  4. A three-dimensional statistical mechanical model of folding double-stranded chain molecules

    NASA Astrophysics Data System (ADS)

    Zhang, Wenbing; Chen, Shi-Jie

    2001-05-01

    Based on a graphical representation of intrachain contacts, we have developed a new three-dimensional model for the statistical mechanics of double-stranded chain molecules. The theory has been tested and validated for the cubic lattice chain conformations. The statistical mechanical model can be applied to the equilibrium folding thermodynamics of a large class of chain molecules, including protein β-hairpin conformations and RNA secondary structures. The application of a previously developed two-dimensional model to RNA secondary structure folding thermodynamics generally overestimates the breadth of the melting curves [S-J. Chen and K. A. Dill, Proc. Natl. Acad. Sci. U.S.A. 97, 646 (2000)], suggesting an underestimation for the sharpness of the conformational transitions. In this work, we show that the new three-dimensional model gives much sharper melting curves than the two-dimensional model. We believe that the new three-dimensional model may give much improved predictions for the thermodynamic properties of RNA conformational changes than the previous two-dimensional model.

  5. Mechanisms and Consequences of Double-strand DNA Break Formation in Chromatin

    PubMed Central

    Cannan, Wendy J.; Pederson, David S.

    2016-01-01

    All organisms suffer double-strand breaks (DSBs) in their DNA as a result of exposure to ionizing radiation. DSBs can also form when replication forks encounter DNA lesions or repair intermediates. The processing and repair of DSBs can lead to mutations, loss of heterozygosity, and chromosome rearrangements that result in cell death or cancer. The most common pathway used to repair DSBs in metazoans (non-homologous DNA end joining) is more commonly mutagenic than the alternative pathway (homologous recombination mediated repair). Thus, factors that influence the choice of pathways used DSB repair can affect an individual’s mutation burden and risk of cancer. This review describes radiological, chemical and biological mechanisms that generate DSBs, and discusses the impact of such variables as DSB etiology, cell type, cell cycle, and chromatin structure on the yield, distribution, and processing of DSBs. The final section focuses on nucleosome-specific mechanisms that influence DSB production, and the possible relationship between higher order chromosome coiling and chromosome shattering (chromothripsis). PMID:26040249

  6. Experimental evidence of a mechanical coupling between layers in an individual double-walled carbon nanotube.

    PubMed

    Levshov, D; Than, T X; Arenal, R; Popov, V N; Parret, R; Paillet, M; Jourdain, V; Zahab, A A; Michel, T; Yuzyuk, Yu I; Sauvajol, J-L

    2011-11-09

    We perform transmission electron microscopy, electron diffraction, and Raman scattering experiments on an individual suspended double-walled carbon nanotube (DWCNT). The first two techniques allow the unambiguous determination of the DWCNT structure: (12,8)@(16,14). However, the low-frequency features in the Raman spectra cannot be connected to the derived layer diameters d by means of the 1/d power law, widely used for the diameter dependence of the radial-breathing mode of single-walled nanotubes. We discuss this disagreement in terms of mechanical coupling between the layers of the DWCNT, which results in collective vibrational modes. Theoretical predictions for the breathing-like modes of the DWCNT, originating from the radial-breathing modes of the layers, are in a very good agreement with the observed Raman spectra. Moreover, the mechanical coupling qualitatively explains the observation of Raman lines of breathing-like modes, whenever only one of the layers is in resonance with the laser energy.

  7. Pricing strategies, the strength of bidding intentions, and online auction performance: a cross-cultural study.

    PubMed

    Peng, Yu-Shu; Jan, Lih-Tsyr

    2009-10-01

    Over the past decade, electronic markets based on the Internet, particularly online auctions, have become popular venues for conducting business. Previous studies often focused on the construction of the best bidding model, while few studies have tried to integrate multiple pricing strategies to predict the probability of closing an auction and the price premium. This study constructs a mediated model to examine the relationship among pricing strategies, the strength of bidding intentions, and online auction performance. The sample consists of 1,055 auctions of iPod MP3 players from eBay Web sites in Hong Kong, Singapore, Belgium, and France. Empirical results show that the pricing strategies directly influence both the probability of closing an auction and the level of price premium. The pricing strategies also indirectly influence the price premium through the mediating effect of the strength of bidding intentions.

  8. 7 CFR 1955.131 - Auctioneers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property Use of Contractors to Dispose of..., location, advertising, broker cooperation, innovations, mechanics of sale, sample advertising,...

  9. Differences and correlations in knee and hip mechanics during single-leg landing, single-leg squat, double-leg landing, and double-leg squat tasks.

    PubMed

    Donohue, Michael R; Ellis, Samantha M; Heinbaugh, Erika M; Stephenson, Mitchell L; Zhu, Qin; Dai, Boyi

    2015-01-01

    Landing and squat tasks have been utilized to assess lower extremity biomechanics associated with anterior cruciate ligament loading and injury risks. The purpose of this study was to identify the differences and correlations in knee and hip mechanics during a single-leg landing, a single-leg squat, a double-leg landing, and a double-leg squat. Seventeen male and 17 female recreational athletes performed landings and squats when kinematic and kinetic data were collected. ANOVAs showed significant differences (p < 0.00001) for maximum knee flexion angles, maximum hip flexion angles, maximum knee abduction angles, maximum hip adduction angles, and maximum external knee abduction moments among squats and landings. For maximum knee and hip flexion angles, significant correlations (r ≥ 0.5, p ≤ 0.003) were observed between the two landings and between the two squats. For maximum knee abduction and hip adduction angles and maximum external knee abduction moments, significant correlations were mostly found between the two landings, and between the single-leg squat and landings (r ≥ 0.54, p ≤ 0.001). Individuals are likely to demonstrate different profiles of injury risks when screened using different tasks. While a double-leg landing should be considered as a priority in screening, a single-leg squat may be used as a surrogate to assess frontal plane motion and loading.

  10. Exploring the mechanism of IR-UV double-resonance for quantitative spectroscopy of protonated polypeptides and proteins.

    PubMed

    Nagornova, Natalia S; Rizzo, Thomas R; Boyarkin, Oleg V

    2013-06-03

    Spectroscopic fingerprint: Infrared–ultraviolet double resonance photodissociation is used for conformational assignment of the electronic spectra of a cold protonated decapeptide (see picture). A mechanism of the IR–UV depletion spectroscopy is proposed and a procedure of using it for measurements of absolute absorption cross-sections of vibrational transitions is elaborated.

  11. Methotrexatum intercalated layered double hydroxides: statistical design, mechanism explore and bioassay study.

    PubMed

    Wang, Xiao-Feng; Liu, Su-Qing; Li, Shu-Ping

    2015-04-01

    A series of methotrexatum intercalated layered double hydroxide (MTX/LDH for short) hybrids have been synthesized by a mechanochemical-hydrothermal method, the statistical experiments are planned and conducted to find out the critical factor influencing the physicochemical properties. Four variables, i.e., addition of NaOH solution, grinding duration, hydrothermal temperature and time, are chosen to play as the examined factors in the orthogonal design. Furthermore, three respective levels, i.e., high, medium and low levels, are conducted in the design. The resulting hybrids are then characterized by X-ray diffraction (XRD) patterns, transmission electron microscope (TEM) graphs and Zeta potentials. XRD diffractions indicate that MTX anions have been successfully intercalated into LDH interlayers and the amount of NaOH solution can change the gallery height greatly. The information from TEM graphs and Zeta potentials state that the increase of alkali solution gives rise to regular morphology and the increase of Zeta potentials. As a result of the statistical analysis, addition of alkali solution is the major factor affecting the morphology and drug-loading capacity. At last, the mechanism of particle growth is explored emphatically, and the anticancer efficacy of some MTX/LDH hybrids is estimated by MTT assay on A549 cells as well.

  12. A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin

    DOE PAGES

    Janssen, Aniek; Breuer, Gregory A.; Brinkman, Eva K.; ...

    2016-07-15

    Repair of DNA double-strand breaks (DSBs) must be properly orchestrated in diverse chromatin regions to maintain genome stability. The choice between two main DSB repair pathways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), is regulated by the cell cycle as well as chromatin context. Pericentromeric heterochromatin forms a distinct nuclear domain that is enriched for repetitive DNA sequences that pose significant challenges for genome stability. Heterochromatic DSBs display specialized temporal and spatial dynamics that differ from euchromatic DSBs. Although HR is thought to be the main pathway used to repair heterochromatic DSBs, direct tests of this hypothesis are lacking. Here,more » we developed an in vivo single DSB system for both heterochromatic and euchromatic loci in Drosophila melanogaster. Live imaging of single DSBs in larval imaginal discs recapitulates the spatio-temporal dynamics observed for irradiation (IR)-induced breaks in cell culture. Importantly, live imaging and sequence analysis of repair products reveal that DSBs in euchromatin and heterochromatin are repaired with similar kinetics, employ both NHEJ and HR, and can use homologous chromosomes as an HR template. This direct analysis reveals important insights into heterochromatin DSB repair in animal tissues and provides a foundation for further explorations of repair mechanisms in different chromatin domains.« less

  13. A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin

    SciTech Connect

    Janssen, Aniek; Breuer, Gregory A.; Brinkman, Eva K.; van der Meulen, Annelot I.; Borden, Sean V.; van Steensel, Bas; Bindra, Ranjit S.; LaRocque, Jeannine R.; Karpen, Gary H.

    2016-07-15

    Repair of DNA double-strand breaks (DSBs) must be properly orchestrated in diverse chromatin regions to maintain genome stability. The choice between two main DSB repair pathways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), is regulated by the cell cycle as well as chromatin context. Pericentromeric heterochromatin forms a distinct nuclear domain that is enriched for repetitive DNA sequences that pose significant challenges for genome stability. Heterochromatic DSBs display specialized temporal and spatial dynamics that differ from euchromatic DSBs. Although HR is thought to be the main pathway used to repair heterochromatic DSBs, direct tests of this hypothesis are lacking. Here, we developed an in vivo single DSB system for both heterochromatic and euchromatic loci in Drosophila melanogaster. Live imaging of single DSBs in larval imaginal discs recapitulates the spatio-temporal dynamics observed for irradiation (IR)-induced breaks in cell culture. Importantly, live imaging and sequence analysis of repair products reveal that DSBs in euchromatin and heterochromatin are repaired with similar kinetics, employ both NHEJ and HR, and can use homologous chromosomes as an HR template. This direct analysis reveals important insights into heterochromatin DSB repair in animal tissues and provides a foundation for further explorations of repair mechanisms in different chromatin domains.

  14. Research on the Mechanical Properties of "Z" Type Double-Decker Ball Bearings.

    PubMed

    Yu, Chengtao; Xu, Longxiang; Yu, Xudong

    2014-01-01

    The mechanical model of a "Z" type double-decker ball bearing under the action of radial load is established in this paper on the basis of the Hertz contact theory. According to the security contact angle theory, the influences of inner and outer bearings' internal clearances on the bearing's static load carrying capacity, radial deformation, radial stiffness, and load distribution of balls are analyzed. This model is verified in both stationary and rotational loading experiments. Moreover, the simulation results show that the static load carrying capacity of Z type bearing is smaller than that of either inner bearing or outer bearing that is contributed to compose the Z type bearing. The static load carrying capacity of a Z type bearing reduces with the increase of the inner and outer bearings' internal clearance. These simulation results also indicate that the contact angle of the maximum loaded ball in the outer bearing easily exceeds its security contact angle compared with the inner bearing, which, as the main factor, may cause the Z type bearing to overload and to fail. In this sense, the investigated Z type bearings are unfit to apply to situations with heavy load, high speed, or high precision.

  15. Multiple mechanisms contribute to double-strand break repair at rereplication forks in Drosophila follicle cells

    PubMed Central

    Alexander, Jessica L.; Beagan, Kelly; Orr-Weaver, Terry L.; McVey, Mitch

    2016-01-01

    Rereplication generates double-strand breaks (DSBs) at sites of fork collisions and causes genomic damage, including repeat instability and chromosomal aberrations. However, the primary mechanism used to repair rereplication DSBs varies across different experimental systems. In Drosophila follicle cells, developmentally regulated rereplication is used to amplify six genomic regions, two of which contain genes encoding eggshell proteins. We have exploited this system to test the roles of several DSB repair pathways during rereplication, using fork progression as a readout for DSB repair efficiency. Here we show that a null mutation in the microhomology-mediated end-joining (MMEJ) component, polymerase θ/mutagen-sensitive 308 (mus308), exhibits a sporadic thin eggshell phenotype and reduced chorion gene expression. Unlike other thin eggshell mutants, mus308 displays normal origin firing but reduced fork progression at two regions of rereplication. We also find that MMEJ compensates for loss of nonhomologous end joining to repair rereplication DSBs in a site-specific manner. Conversely, we show that fork progression is enhanced in the absence of both Drosophila Rad51 homologs, spindle-A and spindle-B, revealing homologous recombination is active and actually impairs fork movement during follicle cell rereplication. These results demonstrate that several DSB repair pathways are used during rereplication in the follicle cells and their contribution to productive fork progression is influenced by genomic position and repair pathway competition. Furthermore, our findings illustrate that specific rereplication DSB repair pathways can have major effects on cellular physiology, dependent upon genomic context. PMID:27849606

  16. Mechanisms of DNA Packaging by Large Double-Stranded DNA Viruses

    PubMed Central

    Rao, Venigalla B.; Feiss, Michael

    2016-01-01

    Translocation of viral double-stranded DNA (dsDNA) into the icosahedral prohead shell is catalyzed by TerL, a motor protein that has ATPase, endonuclease, and translocase activities. TerL, following endonucleolytic cleavage of immature viral DNA concatemer recognized by TerS, assembles into a pentameric ring motor on the prohead’s portal vertex and uses ATP hydrolysis energy for DNA translocation. TerL’s N-terminal ATPase is connected by a hinge to the C-terminal endonuclease. Inchworm models propose that modest domain motions accompanying ATP hydrolysis are amplified, through changes in electrostatic interactions, into larger movements of the C-terminal domain bound to DNA. In phage φ29, four of the five TerL subunits sequentially hydrolyze ATP, each powering translocation of 2.5 bp. After one viral genome is encapsidated, the internal pressure signals termination of packaging and ejection of the motor. Current focus is on the structures of packaging complexes and the dynamics of TerL during DNA packaging, endonuclease regulation, and motor mechanics. PMID:26958920

  17. Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanism.

    PubMed

    Beishline, Kate; Kelly, Crystal M; Olofsson, Beatrix A; Koduri, Sravanthi; Emrich, Jacqueline; Greenberg, Roger A; Azizkhan-Clifford, Jane

    2012-09-01

    Sp1 is a ubiquitously expressed transcription factor that is phosphorylated by ataxia telangiectasia mutated kinase (ATM) in response to ionizing radiation and H(2)O(2). Here, we show by indirect immunofluorescence that Sp1 phosphorylated on serine 101 (pSp1) localizes to ionizing radiation-induced foci with phosphorylated histone variant γH2Ax and members of the MRN (Mre11, Rad50, and Nbs1) complex. More precise analysis of occupancy of DNA double-strand breaks (DSBs) by chromatin immunoprecipitation (ChIP) shows that Sp1, like Nbs1, resides within 200 bp of DSBs. Using laser microirradiation of cells, we demonstrate that pSp1 is present at DNA DSBs by 7.5 min after induction of damage and remains at the break site for at least 8 h. Depletion of Sp1 inhibits repair of site-specific DNA breaks, and the N-terminal 182-amino-acid peptide, which contains targets of ATM kinase but lacks the zinc finger DNA binding domain, is phosphorylated, localizes to DSBs, and rescues the repair defect resulting from Sp1 depletion. Together, these data demonstrate that Sp1 is rapidly recruited to the region immediately adjacent to sites of DNA DSBs and is required for DSB repair, through a mechanism independent of its sequence-directed transcriptional effects.

  18. Anti-Capture to the Continuum via a Double Collision Mechanism in (e,2e) Collisions

    NASA Astrophysics Data System (ADS)

    Ward, S. J.; Roth, E. G.; Guo, B. N.; Golden, D. E.; Mueller, D. W.

    1997-04-01

    Recently, anti-capture to the continuum occurring via the (Thomas) double collision mechanism has been reported.(D. E. Golden, J. Xu, D. W. Mueller and J. Bernhard, Nucl. Inst. and Meth. in Phys. Res. B 99) 202 (1995).^,(D. E. Golden, Z. Xu, J. Bernhard and D. W. Mueller, J. Phys. B: At. Mol. Opt. Phys. 29) 3741 (1996). The doubly differential cross section was measured in coplanar geometry for electron-impact ionization of argon at a 1000 eV incident energy. The cross section is differential with respect to the solid angle of the ejected electron and scattered electron. The detector (split anode detector) measures the two outgoing electrons at approximately the same angle. Both a sharp dip---the signature of anti-electron capture to the continuum---and the Thomas peak were observed in the cross section. We computed the doubly differential cross section for electron-impact ionization of hydrogen. This was done by including in the Bethe-Born approximation a normalization factor that approximately incorporates electron-electron interactions in the final state. We considered hydrogen both in the ground state and the 2p excited state and were able to reproduce the main features of the measurements.

  19. Studying dielectric mechanism and magnetization of double perovskite Gd2NiMnO6 ceramic

    NASA Astrophysics Data System (ADS)

    Mohapatra, S. R.; Sahu, B.; Kaushik, S. D.; Singh, A. K.

    2016-05-01

    In the present work, the structure, dielectric and magnetic properties of Gd2NiMnO6 double perovskite have been studied. X-Ray diffraction study reveals the phase pure formation of the material that crystallizes into monoclinic phase (space group 'P21/n'). Surface morphology depicts heterogeneous grain distribution with average grain size of ~1 µm. Temperature dependent (50 - 330 K) dielectric measurements at different frequencies (0.5 - 50 kHz) relate to Maxwell-Wagner interfacial polarization model. Giant dielectric constant at 1 kHz for 300 K (ɛ' ~1900) is noticed as compared to that of 50 K (ɛ' ~10) coupled with a peak shift in tan loss towards higher temperature with frequency. The activation energy (0.24 eV) obtained using Arrhenius relation for thermally activated relaxor behavior of the material signifies an electron hopping mechanism between Ni2+ and Mn4+ cations. Lastly, M-H study shows `S' shape hysteresis loop at 50 K with remnant magnetization (Mr) of 0.72 µB/f.u. along with a linear plot for 300 K which reveals paramagnetic nature of the material.

  20. Large displacement behavior of double parallelogram flexure mechanisms with underconstraint eliminators

    SciTech Connect

    Panas, Robert M.

    2016-06-23

    This paper presents a new analytical method for predicting the large displacement behavior of flexural double parallelogram (DP) bearings with underconstraint eliminator (UE) linkages. This closed-form perturbative Euler analysis method is able to – for the first time – directly incorporate the elastomechanics of a discrete UE linkage, which is a hybrid flexure element that is linked to ground as well as both stages on the bearing. The models are used to understand a nested linkage UE design, however the method is extensible to other UE linkages. Design rules and figures-of-merit are extracted from the analysis models, which provide powerful tools for accelerating the design process. The models, rules and figures-of-merit enable the rapid design of a UE for a desired large displacement behavior, as well as providing a means for determining the limits of UE and DP structures. This will aid in the adoption of UE linkages into DP bearings for precision mechanisms. Models are generated for a nested linkage UE design, and the performance of this DP with UE structure is compared to a DP-only bearing. As a result, the perturbative Euler analysis is shown to match existing theories for DP-only bearings with distributed compliance within ≈2%, and Finite Element Analysis for the DP with UE bearings within an average 10%.

  1. A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin

    PubMed Central

    Janssen, Aniek; Breuer, Gregory A.; Brinkman, Eva K.; van der Meulen, Annelot I.; Borden, Sean V.; van Steensel, Bas; Bindra, Ranjit S.; LaRocque, Jeannine R.; Karpen, Gary H.

    2016-01-01

    Repair of DNA double-strand breaks (DSBs) must be properly orchestrated in diverse chromatin regions to maintain genome stability. The choice between two main DSB repair pathways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), is regulated by the cell cycle as well as chromatin context. Pericentromeric heterochromatin forms a distinct nuclear domain that is enriched for repetitive DNA sequences that pose significant challenges for genome stability. Heterochromatic DSBs display specialized temporal and spatial dynamics that differ from euchromatic DSBs. Although HR is thought to be the main pathway used to repair heterochromatic DSBs, direct tests of this hypothesis are lacking. Here, we developed an in vivo single DSB system for both heterochromatic and euchromatic loci in Drosophila melanogaster. Live imaging of single DSBs in larval imaginal discs recapitulates the spatio–temporal dynamics observed for irradiation (IR)-induced breaks in cell culture. Importantly, live imaging and sequence analysis of repair products reveal that DSBs in euchromatin and heterochromatin are repaired with similar kinetics, employ both NHEJ and HR, and can use homologous chromosomes as an HR template. This direct analysis reveals important insights into heterochromatin DSB repair in animal tissues and provides a foundation for further explorations of repair mechanisms in different chromatin domains. PMID:27474442

  2. Large displacement behavior of double parallelogram flexure mechanisms with underconstraint eliminators

    SciTech Connect

    Panas, Robert M.

    2016-06-23

    This paper presents a new analytical method for predicting the large displacement behavior of flexural double parallelogram (DP) bearings with underconstraint eliminator (UE) linkages. This closed-form perturbative Euler analysis method is able to – for the first time – directly incorporate the elastomechanics of a discrete UE linkage, which is a hybrid flexure element that is linked to ground as well as both stages on the bearing. The models are used to understand a nested linkage UE design, however the method is extensible to other UE linkages. Design rules and figures-of-merit are extracted from the analysis models, which provide powerful tools for accelerating the design process. The models, rules and figures-of-merit enable the rapid design of a UE for a desired large displacement behavior, as well as providing a means for determining the limits of UE and DP structures. This will aid in the adoption of UE linkages into DP bearings for precision mechanisms. Models are generated for a nested linkage UE design, and the performance of this DP with UE structure is compared to a DP-only bearing. As a result, the perturbative Euler analysis is shown to match existing theories for DP-only bearings with distributed compliance within ≈2%, and Finite Element Analysis for the DP with UE bearings within an average 10%.

  3. Large displacement behavior of double parallelogram flexure mechanisms with underconstraint eliminators

    DOE PAGES

    Panas, Robert M.

    2016-06-23

    This paper presents a new analytical method for predicting the large displacement behavior of flexural double parallelogram (DP) bearings with underconstraint eliminator (UE) linkages. This closed-form perturbative Euler analysis method is able to – for the first time – directly incorporate the elastomechanics of a discrete UE linkage, which is a hybrid flexure element that is linked to ground as well as both stages on the bearing. The models are used to understand a nested linkage UE design, however the method is extensible to other UE linkages. Design rules and figures-of-merit are extracted from the analysis models, which provide powerfulmore » tools for accelerating the design process. The models, rules and figures-of-merit enable the rapid design of a UE for a desired large displacement behavior, as well as providing a means for determining the limits of UE and DP structures. This will aid in the adoption of UE linkages into DP bearings for precision mechanisms. Models are generated for a nested linkage UE design, and the performance of this DP with UE structure is compared to a DP-only bearing. As a result, the perturbative Euler analysis is shown to match existing theories for DP-only bearings with distributed compliance within ≈2%, and Finite Element Analysis for the DP with UE bearings within an average 10%.« less

  4. Hydroxy double salts loaded with bioactive ions: Synthesis, intercalation mechanisms, and functional performance

    SciTech Connect

    Kaassis, Abdessamad Y.A.; Xu, Si-Min; Guan, Shanyue; Evans, David G.; Wei, Min; Williams, Gareth R.

    2016-06-15

    The intercalation of the anions of diclofenac (Dic), naproxen (Nap), and valproic acid (Val) into three hydroxy double salts (HDSs) has been explored in this work. Experiments were performed with [Co{sub 1.2}Zn{sub 3.8}(OH){sub 8}](NO{sub 3}){sub 2}·2H{sub 2}O (CoZn-NO{sub 3}), [Ni{sub 2}Zn{sub 3}(OH){sub 8}](NO{sub 3}){sub 2}·2H{sub 2}O (NiZn-NO{sub 3}) and [Zn{sub 5}(OH){sub 8}](NO{sub 3}){sub 2}·2H{sub 2}O (Zn-NO{sub 3}). It proved possible to intercalate diclofenac and naproxen into all three HDSs. In contrast, Val could be intercalated into CoZn-NO{sub 3} but when it was reacted with Zn-NO{sub 3} the HDS structure was destroyed, and the product comprised ZnO. Successful intercalation was verified by X-ray diffraction, IR spectroscopy, and elemental microanalysis. Molecular dynamics simulations showed the Dic and Nap ions to arrange themselves in an “X” shape in the interlayer space, forming a bilayer. Val was found to adopt a position with its aliphatic groups parallel to the HDS layer, again in a bilayer. In situ time resolved X-ray diffraction experiments revealed that intercalation of Dic and Nap into CoZn-NO{sub 3} and Zn-NO{sub 3} is mechanistically complex, with a number of intermediate phases observed. In contrast, the intercalation of all three guests into NiZn-NO{sub 3} and of Val into CoZn-NO{sub 3} are simple one step reactions proceeding directly from the starting material to the product. The HDS-drug composites were found to have sustained release profiles. - Graphical abstract: Seven new drug intercalates of hydroxy double salts (HDSs) have been prepared and characterised. The intercalation mechanisms have been explored, and the drug release properties of the HDS/drug composites quantified. Display Omitted.

  5. A possible formation mechanism of double-walled and multi-walled carbon nanotube: a molecular dynamics study

    NASA Astrophysics Data System (ADS)

    Han, Dianrong; Luo, Chenglin; Dai, Yafei; Zhu, Xingfeng

    2016-09-01

    Molecular dynamics simulations based on an empirical potential were performed to study the interaction of graphene nanoribbons and the single-walled carbon nanotubes. The results indicated that a piece of graphene nanoribbon can form a tube structure inside or outside single-walled carbon nanotubes spontaneously under certain condition. Based on this kind of spontaneous phenomenon, we proposed a new possible formation mechanism of double walled carbon nanotube and multi-walled carbon nanotube, and suggested the possibility of controlling the structure of double-walled carbon nanotube and/or multi-walled carbon nanotube.

  6. Multi-level quantum mechanics theories and molecular mechanics study of the double-inversion mechanism of the F(-) + CH3I reaction in aqueous solution.

    PubMed

    Liu, Peng; Zhang, Jingxue; Wang, Dunyou

    2017-06-07

    A double-inversion mechanism of the F(-) + CH3I reaction was discovered in aqueous solution using combined multi-level quantum mechanics theories and molecular mechanics. The stationary points along the reaction path show very different structures to the ones in the gas phase due to the interactions between the solvent and solute, especially strong hydrogen bonds. An intermediate complex, a minimum on the potential of mean force, was found to serve as a connecting-link between the abstraction-induced inversion transition state and the Walden-inversion transition state. The potentials of mean force were calculated with both the DFT/MM and CCSD(T)/MM levels of theory. Our calculated free energy barrier of the abstraction-induced inversion is 69.5 kcal mol(-1) at the CCSD(T)/MM level of theory, which agrees with the one at 72.9 kcal mol(-1) calculated using the Born solvation model and gas-phase data; and our calculated free energy barrier of the Walden inversion is 24.2 kcal mol(-1), which agrees very well with the experimental value at 25.2 kcal mol(-1) in aqueous solution. The calculations show that the aqueous solution makes significant contributions to the potentials of mean force and exerts a big impact on the molecular-level evolution along the reaction pathway.

  7. Identification of shareholder ethics and responsibilities in online reverse auctions for construction projects.

    PubMed

    Hatipkarasulu, Yilmaz; Gill, James H

    2004-04-01

    The increasing number of companies providing internet services and auction tools helped popularize the online reverse auction trend for purchasing commodities and services in the last decade. As a result, a number of owners, both public and private, accepted the online reverse auctions as the bidding technique for their construction projects. Owners, while trying to minimize their costs for construction projects, are also required to address their ethical responsibilities to the shareholders. In the case of online reverse auctions for construction projects, the ethical issues involved in the bidding technique directly reflects on the owner's ethical and social responsibilities to their shareholders. The goal of this paper is to identify the shareholder ethics and responsibilities in online reverse auctions for construction projects by analyzing the ethical issues for the parties involved in the process. The identification of the ethical issues and responsibilities requires clear definition and understanding of professional ethics and the roles of the involved parties. In this paper, first, the concept of professional ethics and social responsibility is described in a general form. To illustrate the ethical issues and responsibilities, a sample case of bidding for a construction project using online reverse auction techniques is presented in which the shareholders were actively involved in questioning the ethical issues. The issues involved in the bidding process and their reflection on the shareholder responsibilities are described and analyzed for each stage of the process. A brief discussion of the overall process is also included to address the general ethical issues involved in online reverse auctions.

  8. A mechanical spectrum study of double perovskite Y 1- xCa xBaCuFeO 5+δ

    NASA Astrophysics Data System (ADS)

    Ying, X. N.; Xu, Z. C.

    2008-05-01

    The mechanical spectrum of double perovskite Y BaCuFeO 5+δ was measured using the vibrating reed method from 100 K to room temperature at kilohertz frequency. A sharp internal friction peak around 203 K and a broad one around 260 K were observed in Y BaCuFeO 5+δ. A deviation of the temperature dependent reduced modulus from linear behavior above 203 K is observed which is concurrent with the sharp internal friction peak. This suggests a phase transition mechanism of the sharp internal friction peak. The intensities of the two internal friction peaks were both depressed upon partial Ca substitution of Y. By comparison of the mechanical spectrum with the bilayer superconductor Y Ba 2Cu 3O 7+δ, one kind of transition in double perovskite oxide is proposed for the sharp internal friction peak.

  9. Single- and double-row repair for rotator cuff tears - biology and mechanics.

    PubMed

    Papalia, Rocco; Franceschi, Francesco; Vasta, Sebastiano; Zampogna, Biagio; Maffulli, Nicola; Denaro, Vincenzo

    2012-01-01

    We critically review the existing studies comparing the features of single- and double-row repair, and discuss suggestions about the surgical indications for the two repair techniques. All currently available studies comparing the biomechanical, clinical and the biological features of single and double row. Biomechanically, the double-row repair has greater performances in terms of higher initial fixation strength, greater footprint coverage, improved contact area and pressure, decreased gap formation, and higher load to failure. Results of clinical studies demonstrate no significantly better outcomes for double-row compared to single-row repair. Better results are achieved by double-row repair for larger lesions (tear size 2.5-3.5 cm). Considering the lack of statistically significant differences between the two techniques and that the double row is a high cost and a high surgical skill-dependent technique, we suggest using the double-row technique only in strictly selected patients. Copyright © 2012 S. Karger AG, Basel.

  10. Multiagent model and mean field theory of complex auction dynamics

    NASA Astrophysics Data System (ADS)

    Chen, Qinghua; Huang, Zi-Gang; Wang, Yougui; Lai, Ying-Cheng

    2015-09-01

    Recent years have witnessed a growing interest in analyzing a variety of socio-economic phenomena using methods from statistical and nonlinear physics. We study a class of complex systems arising from economics, the lowest unique bid auction (LUBA) systems, which is a recently emerged class of online auction game systems. Through analyzing large, empirical data sets of LUBA, we identify a general feature of the bid price distribution: an inverted J-shaped function with exponential decay in the large bid price region. To account for the distribution, we propose a multi-agent model in which each agent bids stochastically in the field of winner’s attractiveness, and develop a theoretical framework to obtain analytic solutions of the model based on mean field analysis. The theory produces bid-price distributions that are in excellent agreement with those from the real data. Our model and theory capture the essential features of human behaviors in the competitive environment as exemplified by LUBA, and may provide significant quantitative insights into complex socio-economic phenomena.

  11. Using Experimental Auctions to Examine Demand for E-Cigarettes.

    PubMed

    O'Connor, Richard; Rousu, Matthew C; Bansal-Travers, Maansi; Vogl, Lisa; Corrigan, Jay R

    2017-06-01

    E-cigarettes are the latest in a line of potentially reduced exposure products that have garnered interest among smokers. In this paper, we use experimental auctions to estimate smokers' demand for e-cigarettes and to assess the impact of advertisements on willingness to pay. These are actual auctions, with winners and losers, which means hypothetical biases often seen in surveys are minimized. We find smokers have positive demand for e-cigarettes, and that the print advertisements used in our study had greater effectiveness than video ads (b = 2.00, p < .05) in terms of increasing demand for disposable e-cigarettes. Demand was greater for reusable versus disposable e-cigarettes. In multivariate models, demand for e-cigarettes was higher among non-white participants and among smokers willing to pay more for cigarettes. Our findings suggest that cigarette smokers are interested in e-cigarettes as alternatives to traditional products, particularly for reusable forms, and that this demand can be influenced by messaging/advertising. Given these reduced harm products are appealing, if smokers are able to switch completely to e-cigarettes, there is a good chance for accrual of significant harm reduction.

  12. Mechanisms of fast and stringent search in homologous pairing of double-stranded DNA

    PubMed Central

    Chiang, Wei-Yin; Prentiss, Mara

    2017-01-01

    Self-organization in the cell relies on the rapid and specific binding of molecules to their cognate targets. Correct bindings must be stable enough to promote the desired function even in the crowded and fluctuating cellular environment. In systems with many nearly matched targets, rapid and stringent formation of stable products is challenging. Mechanisms that overcome this challenge have been previously proposed, including separating the process into multiple stages; however, how particular in vivo systems overcome the challenge remains unclear. Here we consider a kinetic system, inspired by homology dependent pairing between double stranded DNA in bacteria. By considering a simplified tractable model, we identify different homology testing stages that naturally occur in the system. In particular, we first model dsDNA molecules as short rigid rods containing periodically spaced binding sites. The interaction begins when the centers of two rods collide at a random angle. For most collision angles, the interaction energy is weak because only a few binding sites near the collision point contribute significantly to the binding energy. We show that most incorrect pairings are rapidly rejected at this stage. In rare cases, the two rods enter a second stage by rotating into parallel alignment. While rotation increases the stability of matched and nearly matched pairings, subsequent rotational fluctuations reduce kinetic trapping. Finally, in vivo chromosome are much longer than the persistence length of dsDNA, so we extended the model to include multiple parallel collisions between long dsDNA molecules, and find that those additional interactions can greatly accelerate the searching. PMID:28257444

  13. Mechanisms of fast and stringent search in homologous pairing of double-stranded DNA.

    PubMed

    Bitran, Amir; Chiang, Wei-Yin; Levine, Erel; Prentiss, Mara

    2017-03-01

    Self-organization in the cell relies on the rapid and specific binding of molecules to their cognate targets. Correct bindings must be stable enough to promote the desired function even in the crowded and fluctuating cellular environment. In systems with many nearly matched targets, rapid and stringent formation of stable products is challenging. Mechanisms that overcome this challenge have been previously proposed, including separating the process into multiple stages; however, how particular in vivo systems overcome the challenge remains unclear. Here we consider a kinetic system, inspired by homology dependent pairing between double stranded DNA in bacteria. By considering a simplified tractable model, we identify different homology testing stages that naturally occur in the system. In particular, we first model dsDNA molecules as short rigid rods containing periodically spaced binding sites. The interaction begins when the centers of two rods collide at a random angle. For most collision angles, the interaction energy is weak because only a few binding sites near the collision point contribute significantly to the binding energy. We show that most incorrect pairings are rapidly rejected at this stage. In rare cases, the two rods enter a second stage by rotating into parallel alignment. While rotation increases the stability of matched and nearly matched pairings, subsequent rotational fluctuations reduce kinetic trapping. Finally, in vivo chromosome are much longer than the persistence length of dsDNA, so we extended the model to include multiple parallel collisions between long dsDNA molecules, and find that those additional interactions can greatly accelerate the searching.

  14. The design and analysis of a double swivel toggle release mechanism for the Orbiter stabilized payload deployment system

    NASA Technical Reports Server (NTRS)

    King, Guy L.; Tsai, Ted

    1989-01-01

    The NASA Stabilized Payload Deployment System (SPDS) is discussed. The lightweight and heavy-duty system rolls payloads over the orbiter's side rather than ejecting them upward. The system will enhance the orbiter capability of carrying larger and heavier payloads. The design, function, and analysis of a new three-pin double swivel toggle release mechanism which is crucial to the successful deployment of the SPDS are described.

  15. Double-inversion mechanisms of the X⁻ + CH₃Y [X,Y = F, Cl, Br, I] SN2 reactions.

    PubMed

    Szabó, István; Czakó, Gábor

    2015-03-26

    The double-inversion and front-side attack transition states as well as the proton-abstraction channels of the X(-) + CH3Y [X,Y = F, Cl, Br, I] reactions are characterized by the explicitly correlated CCSD(T)-F12b/aug-cc-pVTZ(-PP) level of theory using small-core relativistic effective core potentials and the corresponding aug-cc-pVTZ-PP bases for Br and I. In the X = F case the double-inversion classical(adiabatic) barrier heights are 28.7(25.6), 15.8(13.4), 13.2(11.0), and 8.6(6.6) kcal mol(-1) for Y = F, Cl, Br, and I, respectively, whereas the barrier heights are in the 40-90 kcal mol(-1) range for the other 12 reactions. The abstraction channels are always above the double-inversion saddle points. For X = F, the front-side attack classical(adiabatic) barrier heights, 45.8(44.8), 31.0(30.3), 24.7(24.2), and 19.5(19.3) kcal mol(-1) for Y = F, Cl, Br, and I, respectively, are higher than the corresponding double-inversion ones, whereas for the other systems the front-side attack saddle points are in the 35-70 kcal mol(-1) range. The double-inversion transition states have XH···CH2Y(-) structures with Cs point-group symmetry, and the front-side attack saddle points have either Cs (X = F or X = Y) or C1 symmetry with XCY angles in the 78-88° range. On the basis of the previous reaction dynamics simulations and the minimum energy path computations along the inversion coordinate of selected XH···CH2Y(-) systems, we suggest that the double inversion may be a general mechanism for SN2 reactions.

  16. A mechanism for weak double layers and coherent low-frequency electrostatic wave activity in the solar wind

    NASA Astrophysics Data System (ADS)

    Singh Lakhina, Gurbax; Singh, Satyavir

    2016-07-01

    A mechanism for the weak double layers and coherent low-frequency electrostatic wave activity observed by Wind spacecraft in the solar wind at 1 AU is proposed in terms of ion-acoustic solitons and double layers. The solar wind plasma is modelled by a three component plasma consisting of fluid hot protons, hot alpha particles streaming with respect to protons, and suprathermal electrons having κ- distribution. This system supports two types of, slow and fast, ion-acoustic solitary waves. The fast ion-acoustic mode is similar to the ion-acoustic mode of proton-electron plasma, and can support only positive potential solitons. The slow ion-acoustic mode is a new mode that occurs due to the presence of alpha particles. This mode can support both positive and negative solitons and double layers. An increase of the κ- index leads to an increase in the critical Mach number, maximum Mach number and the maximum amplitude of both slow and fast ion-acoustic solitons. The slow ion-acoustic double layer can explain the amplitudes and widths, but not shapes, of the weak double layers (WDLs) observed in the solar wind at 1 AU by Wind spacecraft. The Fourier transform of the slow ion-acoustic solitons/double layers would produce broadband low-frequency electrostatic waves having main peaks between 0.35 kHz to 1.6 kHz, with electric field in the range of E = (0.01 - 0.7 ) mV/m, in excellent agreement with the observed low-frequency electrostatic wave activity in the solar wind at 1 AU.

  17. Understanding overbidding: using the neural circuitry of reward to design economic auctions.

    PubMed

    Delgado, Mauricio R; Schotter, Andrew; Ozbay, Erkut Y; Phelps, Elizabeth A

    2008-09-26

    We take advantage of our knowledge of the neural circuitry of reward to investigate a puzzling economic phenomenon: Why do people overbid in auctions? Using functional magnetic resonance imaging (fMRI), we observed that the social competition inherent in an auction results in a more pronounced blood oxygen level-dependent (BOLD) response to loss in the striatum, with greater overbidding correlated with the magnitude of this response. Leveraging these neuroimaging results, we design a behavioral experiment that demonstrates that framing an experimental auction to emphasize loss increases overbidding. These results highlight a role for the contemplation of loss in understanding the tendency to bid "too high." Current economic theories suggest overbidding may result from either "joy of winning" or risk aversion. By combining neuroeconomic and behavioral economic techniques, we find that another factor, namely loss contemplation in a social context, may mediate overbidding in auctions.

  18. Understanding Overbidding: Using the Neural Circuitry of Reward to Design Economic Auctions

    PubMed Central

    Delgado, Mauricio R.; Schotter, Andrew; Ozbay, Erkut Y.; Phelps, Elizabeth A.

    2011-01-01

    We take advantage of our knowledge of the neural circuitry of reward to investigate a puzzling economic phenomenon: Why do people overbid in auctions? Using functional magnetic resonance imaging (fMRI), we observed that the social competition inherent in an auction results in a more pronounced blood oxygen level–dependent (BOLD) response to loss in the striatum, with greater overbidding correlated with the magnitude of this response. Leveraging these neuroimaging results, we design a behavioral experiment that demonstrates that framing an experimental auction to emphasize loss increases overbidding. These results highlight a role for the contemplation of loss in understanding the tendency to bid “too high.” Current economic theories suggest overbidding may result from either “joy of winning” or risk aversion. By combining neuroeconomic and behavioral economic techniques, we find that another factor, namely loss contemplation in a social context, may mediate overbidding in auctions. PMID:18818362

  19. Bid distribution derived from consistent mixed strategy in lowest unique bid auction

    NASA Astrophysics Data System (ADS)

    Zhao, Yinan; Chen, Qinghua; Wang, Yougui

    2014-12-01

    The Lowest Unique Bid Auction (LUBA) booms recently through the Internet. A typical distribution pattern of bid price in this reverse auction has been found and needs to be interpreted. The distribution curve is a decreasing one whose slope has a close relationship with the number of agents participating in the auction. To explain this stylized fact, we develop a model assuming that agents prefer to bid on the price at which the probability of winning is higher. The bid distributions of actual auctions with the number of agents less than 200 can be fitted very well using the parameters for the value of items and the number of bids. When this number becomes larger, however, a deviation occurs between prediction and empirical data, which can be adjusted by introducing cognitive illusion of the bid number.

  20. 31 CFR 356.11 - How are bids submitted in an auction?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... participating in our auctions. (3) In contingency situations, such as a power outage, we may accept bids by a... Identification Number. (4) In contingency situations, such as a power outage, we may accept bids by other...

  1. 78 FR 56874 - Comment Sought on Petition for Reconsideration of Auction 902 Procedures Public Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ... must refer to AU Docket No. 13-53. The Wireless Telecommunications Bureau and Wireline Competition... Commission's Web site: http://wireless.fcc.gov/auctions/902/ , or by using the search function for AU Docket...

  2. Fault structure and mechanics of the Hayward Fault, California from double-difference earthquake locations

    USGS Publications Warehouse

    Waldhauser, F.; Ellsworth, W.L.

    2002-01-01

    The relationship between small-magnitude seismicity and large-scale crustal faulting along the Hayward Fault, California, is investigated using a double-difference (DD) earthquake location algorithm. We used the DD method to determine high-resolution hypocenter locations of the seismicity that occurred between 1967 and 1998. The DD technique incorporates catalog travel time data and relative P and S wave arrival time measurements from waveform cross correlation to solve for the hypocentral separation between events. The relocated seismicity reveals a narrow, near-vertical fault zone at most locations. This zone follows the Hayward Fault along its northern half and then diverges from it to the east near San Leandro, forming the Mission trend. The relocated seismicity is consistent with the idea that slip from the Calaveras Fault is transferred over the Mission trend onto the northern Hayward Fault. The Mission trend is not clearly associated with any mapped active fault as it continues to the south and joins the Calaveras Fault at Calaveras Reservoir. In some locations, discrete structures adjacent to the main trace are seen, features that were previously hidden in the uncertainty of the network locations. The fine structure of the seismicity suggest that the fault surface on the northern Hayward Fault is curved or that the events occur on several substructures. Near San Leandro, where the more westerly striking trend of the Mission seismicity intersects with the surface trace of the (aseismic) southern Hayward Fault, the seismicity remains diffuse after relocation, with strong variation in focal mechanisms between adjacent events indicating a highly fractured zone of deformation. The seismicity is highly organized in space, especially on the northern Hayward Fault, where it forms horizontal, slip-parallel streaks of hypocenters of only a few tens of meters width, bounded by areas almost absent of seismic activity. During the interval from 1984 to 1998, when digital

  3. Physical Mechanisms and Scaling Laws of K-Shell Double Photoionization

    SciTech Connect

    Hoszowska, J.; Dousse, J.-Cl.; Berset, M.; Cao, W.; Fennane, K.; Kayser, Y.; Szlachetko, J.; Szlachetko, M.; Kheifets, A. K.; Bray, I.; Kavcic, M.

    2009-02-20

    We report on the photon energy dependence of the K-shell double photoionization (DPI) of Mg, Al, and Si. The DPI cross sections were derived from high-resolution measurements of x-ray spectra following the radiative decay of the K-shell double vacancy states. Our data evince the relative importance of the final-state electron-electron interaction to the DPI. By comparing the double-to-single K-shell photoionization cross-section ratios for neutral atoms with convergent close-coupling calculations for He-like ions, the effect of outer shell electrons on the K-shell DPI process is assessed. Universal scaling of the DPI cross sections with the effective nuclear charge for neutral atoms is revealed.

  4. Physical Mechanisms and Scaling Laws of K-Shell Double Photoionization

    NASA Astrophysics Data System (ADS)

    Hoszowska, J.; Kheifets, A. K.; Dousse, J.-Cl.; Berset, M.; Bray, I.; Cao, W.; Fennane, K.; Kayser, Y.; Kavčič, M.; Szlachetko, J.; Szlachetko, M.

    2009-02-01

    We report on the photon energy dependence of the K-shell double photoionization (DPI) of Mg, Al, and Si. The DPI cross sections were derived from high-resolution measurements of x-ray spectra following the radiative decay of the K-shell double vacancy states. Our data evince the relative importance of the final-state electron-electron interaction to the DPI. By comparing the double-to-single K-shell photoionization cross-section ratios for neutral atoms with convergent close-coupling calculations for He-like ions, the effect of outer shell electrons on the K-shell DPI process is assessed. Universal scaling of the DPI cross sections with the effective nuclear charge for neutral atoms is revealed.

  5. Synthetic aperture double exposure digital holographic interferometry for wide angle measurement and monitoring of mechanical displacements

    NASA Astrophysics Data System (ADS)

    Kujawinska, M.; Makowski, P.; Finke, G.; Zak, J.; Józwik, M.; Kozacki, T.

    2015-08-01

    A novel approach for wide angle registration and display of double exposure digital holograms of 3D objects under static or step-wise load is presented. The registration setup concept combines digital Fourier holography with synthetic aperture (SA) technique, which is equivalent to usage of a wide angle, spherically curved detector. The coherent object wavefields extracted from a pair of acquisitions collected in the synthetic aperture double exposure digital holographic interferometry scheme (SA DEDH) are utilized as the input for two different scenarios of investigation, which include (i) numerical determination of 2D phase difference fringes representing deformation of an object and (ii) physical displaying of a 3D image resulting from interference of two object (slightly different) wavefronts registered at the SA double exposure hologram. The capture and display processes are analyzed and implemented. The applicability of both numerical and experimental approach to SA DEDH for testing engineering objects is discussed.

  6. The Allocation of Runway Slots by Auction. Volume III. Theory and Technical Issues for Implementation.

    DTIC Science & Technology

    1980-04-15

    air polution , noise, landside traffic c.)ngestion and so on--dictate a different approach at l_ ast for some congested airports (notably Washington...approaches to slot auctions have not allowed for the inter- dependency of slot values to the air carriers--a single slot for a landing of an aircraft is...slot exchange. 17. Key Woeds II. Distrlbution Stmtome Slot, exchange, auction, trading, air Document is available to the public carriers, allocation

  7. Product definition for future electricity supply auctions: the 2006 Illinois experience

    SciTech Connect

    de Castro, Luciano; Negrete-Pincetic, Matias; Gross, George

    2008-08-15

    Much of the discussion about new markets for electricity contracts focuses on the auction format to be used. Far less attention has been paid to the contract definition itself. An analysis of the 2006 Illinois Electricity Auction shows how a poorly formulated product definition can erode the performance of such markets. The authors propose an improved product definition to overcome the key problems they have identified. (author)

  8. The mechanism of double-exponential growth in hyper-inflation

    NASA Astrophysics Data System (ADS)

    Mizuno, T.; Takayasu, M.; Takayasu, H.

    2002-05-01

    Analyzing historical data of price indices, we find an extraordinary growth phenomenon in several examples of hyper-inflation in which, price changes are approximated nicely by double-exponential functions of time. In order to explain such behavior we introduce the general coarse-graining technique in physics, the Monte Carlo renormalization group method, to the price dynamics. Starting from a microscopic stochastic equation describing dealers’ actions in open markets, we obtain a macroscopic noiseless equation of price consistent with the observation. The effect of auto-catalytic shortening of characteristic time caused by mob psychology is shown to be responsible for the double-exponential behavior.

  9. Combining auctions and performance-based payments in a forest enrichment field trial in Western Kenya.

    PubMed

    Khalumba, Mercelyne; Wünscher, Tobias; Wunder, Sven; Büdenbender, Mirjam; Holm-Müller, Karin

    2014-06-01

    Cost-effectiveness is an important aspect in the assessment of payments for environmental services (PES) initiatives. In participatory field trials with communities in Western Kenya, we combined procurement auctions for forest enrichment contracts with performance-based payments and compared the outcomes with a baseline scenario currently used by the Kenyan Forest Service. Procurement auctions were the most cost-effective. The competitive nature of the auction reduced contracting expenses (provision costs), and the result-oriented payments provided additional incentives to care for the planted seedlings, resulting in their improved survival rates (service quantity). These gains clearly exceeded increases in transaction costs associated with conducting an auction. The number of income-poor auction participants and winners was disproportionately high and local institutional buy-in was remarkably strong. Our participatory approach may, however, require adaptations when conducted at a larger scale. Although the number of contracts we monitored was limited and prohibited the use of statistical tests, our study is one of the first to reveal the benefits of using auctions for PES in developing countries. © 2014 Society for Conservation Biology.

  10. Argentine drilling equipment to go on auction block

    SciTech Connect

    Not Available

    1992-04-27

    Yacimientos Petroliferos Fiscales (YPF) is preparing to sell all state owned drilling rigs and related assets as part of a plan to privatize Argnetina's oil and gas industry. YPF expects to offer the equipment to private companies by summer in a sealed bid auction in Buenos Aires. More than 30 mostly late model U.S. and Romanian rigs rated to 1,800-7,000 m will be included in the sale. Drilling contracts covering all major Argentina exploration areas will be offered with many of the rigs being sold. This paper reports that the YPF sale will include well completion units, drill pipe and collars, large equipment yards, shops, and warehouses, and possibly the largest inventory of fishing tools in South America, says a company helping to organize the sale. YPF will set up a data room in Buenos Aires to provide information about drilling, conditions, rigs and equipment, and other assets.

  11. Effects of whole-body mechanical stimulation at double the heart rate on the blood pressure waveform in rats.

    PubMed

    Hsiu, H; Jan, M Y; Wang, W K; Wang, Y Y Lin

    2006-02-01

    The effects of mechanical stimulation on hemodynamics, such as due to mechanotransduction in vascular endothelial cells, have been widely discussed recently. We previously proposed a resonance model in which the arterial system is treated as a pressure-transmitting system, and suggested that the application of external mechanical stimulation with frequencies near the heart rate (HR) or harmonics thereof can be sensed by the arterial system and induce hemodynamic changes. In this study, we monitored the effects of external mechanical stimulation at a frequency of double the HR on BPW (blood pressure waveform), HRV (HR variability) and BPHV (blood-pressure-harmonics variability) in rats. A motor beating a waterbed mattress was used to generate pressure variations of 0.5 mmHg to apply onto the rats. The experiments were performed on three groups of rats with different beating frequencies: (A) double the HR, (B) 5% deviation from double the HR and (C) 1.5 times the HR. The experimental procedure was a 15 min control period followed by application of the mechanical stimulation for 15 min and further recording for 15 min (OFF period). During the OFF period, the amplitude of the second harmonic in the BPW significantly increased by >5% in group A with decreased HRV and BPHV. The second harmonic increased less in group B, and decreased in group C. The increase in the second-harmonic amplitude in group A may be due to the filtering properties of the renal arterial structure. This mechanism could be used to improve the local blood supply into the kidneys, and hence provide a new treatment modality for some important diseases, such as renal hypertension or nephrosis.

  12. Improvement of Thermo-Mechanical Properties of Short Natural Fiber Reinforced Recycled Polypropylene Composites through Double Step Grafting Process

    NASA Astrophysics Data System (ADS)

    Saputra, O. A.; Rini, K. S.; Susanti, T. D.; Mustofa, R. E.; Prameswari, M. D.; Pramono, E.

    2017-07-01

    This study focused on the effect of a compatibilizer addition, maleic anhydrides (MAH) on mechanical, thermal and water absorption properties of oil palm empty fruit bunches (EFB) fiber reinforced recycled polypropylene (rPP) biocomposites. The double steps grafting process were conducted by incorporated MAH on both rPP and EFB to improve the surface adhesion between these materials, to result in a good mechanical properties as well as biocompatibility to nature. The chemical test was carried out using FTIR (Fourier Transform Infra-Red) spectroscopy technique to evaluated grafting process. The mechanical test was investigated and found that the addition of 10 phr MAH to both rPP and EFB improved mechanical strength of the biocomposites higher than another formulas. In this study, thermal properties of biocomposites also characterized. Water absorption (WA) analysis showed the presence of EFB fiber increased the water uptake of the material.

  13. RecBCD is required to complete chromosomal replication: Implications for double-strand break frequencies and repair mechanisms.

    PubMed

    Courcelle, Justin; Wendel, Brian M; Livingstone, Dena D; Courcelle, Charmain T

    2015-08-01

    Several aspects of the mechanism of homologous double-strand break repair remain unclear. Although intensive efforts have focused on how recombination reactions initiate, far less is known about the molecular events that follow. Based upon biochemical studies, current models propose that RecBCD processes double-strand ends and loads RecA to initiate recombinational repair. However, recent studies have shown that RecBCD plays a critical role in completing replication events on the chromosome through a mechanism that does not involve RecA or recombination. Here, we examine several studies, both early and recent, that suggest RecBCD also operates late in the recombination process - after initiation, strand invasion, and crossover resolution have occurred. Similar to its role in completing replication, we propose a model in which RecBCD is required to resect and resolve the DNA synthesis associated with homologous recombination at the point where the missing sequences on the broken molecule have been restored. We explain how the impaired ability to complete chromosome replication in recBC and recD mutants is likely to account for the loss of viability and genome instability in these mutants, and conclude that spontaneous double-strand breaks and replication fork collapse occur far less frequently than previously speculated.

  14. [Research on the mechanical properties of bone scaffold reinforced by magnesium alloy/bioceramics composite with stereolithography double channels].

    PubMed

    Li, Changhai; Lian, Qin; Zhuang, Pei; Wang, Junzhong; Li, Dichen

    2015-02-01

    Focusing on the poor mechanical strength of porous bioceramics bone scaffold, and taking into account of the good mechanical properties of biodegradable magnesium alloy, we proposed a novel method to fabricate magnesium alloy/bioceramics composite bone scaffold with stereolithography double channels. Firstly, a scaffold structure without mutually connected double channels was designed. Then, an optimized bioceramics scaffold was fabricated according to stereolithography and gel-casing. Molten AZ31 magnesium alloy was perfused into the secondary channel of scaffold by low-pressure casting, and magnesium alloy/bioceramics composite bone scaffold was obtained when magnesium alloy was solidified. The compression test showed that the strength of bioceramics scaffold with only one channel and without magnesium alloy was (9.76 ± 0.64) MPa, while the strength of magnesium alloy/bioceramics composite scaffold with double channels was (17.25 ± 0.88) MPa. It can be concluded that the magnesium alloy/bioceramics composite is obviously able to improve the scaffold strength.

  15. 76 FR 78645 - Auction of FM Broadcast Construction Permits Scheduled for March 27, 2012; Notice and Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ... white lights in residential neighborhoods or excessive radio frequency emission. C. Auction Specifics i... power television, television translator or FM translator facilities will not be counted among the...

  16. Green auctions and reduction of information rents in payments for environmental services: an experimental investigation in Sunan County, northwestern China.

    PubMed

    Deng, Xiaohong; Xu, Zhongmin

    2015-01-01

    Reducing information rents is an important task for government agencies wishing to purchase maximal environmental services with limited budgets. This paper reports on several green auction options for reducing information rents and improving the performance of the "Grain for Green" Payments for environmental services (PES) program implemented in northwestern China. In r experimental auctions and investigations, door-to-door interviews were conducted and bidding envelopes and survey questionnaires were used to determine the offers and the foregone profits of the participants. Three scenarios are analyzed in this paper: a uniform price auction, a discriminatory price auction, and an opportunity-cost system. The results show that compared to the uniform price auction system, the other auction systems can increase the cost-effectiveness of conservation contracting. Competitive bidding can reveal true opportunity costs and can reduce information rents extracted from the government by farmers using private information. The demographics and average bids of these auction types were also analyzed. "Perfect information" in the opportunity-cost offer system has the best performance but is very hard to implement in reality. The results of this research show that the auction is a valuable tool for purchasing conservation contracts in northwestern China, but that in the future, the performance of these auctions should be studied with relaxed model assumptions.

  17. Green Auctions and Reduction of Information Rents in Payments for Environmental Services: An Experimental Investigation in Sunan County, Northwestern China

    PubMed Central

    Deng, Xiaohong; Xu, Zhongmin

    2015-01-01

    Reducing information rents is an important task for government agencies wishing to purchase maximal environmental services with limited budgets. This paper reports on several green auction options for reducing information rents and improving the performance of the “Grain for Green” Payments for environmental services (PES) program implemented in northwestern China. In r experimental auctions and investigations, door-to-door interviews were conducted and bidding envelopes and survey questionnaires were used to determine the offers and the foregone profits of the participants. Three scenarios are analyzed in this paper: a uniform price auction, a discriminatory price auction, and an opportunity-cost system. The results show that compared to the uniform price auction system, the other auction systems can increase the cost-effectiveness of conservation contracting. Competitive bidding can reveal true opportunity costs and can reduce information rents extracted from the government by farmers using private information. The demographics and average bids of these auction types were also analyzed. “Perfect information” in the opportunity-cost offer system has the best performance but is very hard to implement in reality. The results of this research show that the auction is a valuable tool for purchasing conservation contracts in northwestern China, but that in the future, the performance of these auctions should be studied with relaxed model assumptions. PMID:25793263

  18. The detection system of local mechanical strength of material based on double-hole micro-shear

    NASA Astrophysics Data System (ADS)

    Ding, Shoucheng; Li, Wenhui; Yang, Shizhou; Yuan, Guici

    2008-12-01

    The paper introduces a detection system of local mechanical strength of material. The principle of the system is based on the double-hole micro-shear test method. The core of detection system is MSP430F149 SCM. The working principle of the system is that the shear tool is driven by the stepper motor; the data is gathered by the load sensor and the displacement sensor; after it is processed by A/D converter of MSP430F149 SCM, we can gain the load and the displacement curve and get the maximum point of yield strength; according to the load value, the system determines the material mechanical intensity; Thus, a real-time detection system is set up. Experimental results show that detecting system based on double-hole micro-shear is fast, easy, accurate and intuitive to detect mechanical strength of the local material. So it can be widely applied to detect the local mechanical strength of kinds of mining and load bearing equipment via setting reasonable load value, which can avoid the accident of overload or super strength effectively.

  19. Quantum interactive learning tutorial on the double-slit experiment to improve student understanding of quantum mechanics

    NASA Astrophysics Data System (ADS)

    Sayer, Ryan; Maries, Alexandru; Singh, Chandralekha

    2017-06-01

    Learning quantum mechanics is challenging, even for upper-level undergraduate and graduate students. Research-validated interactive tutorials that build on students' prior knowledge can be useful tools to enhance student learning. We have been investigating student difficulties with quantum mechanics pertaining to the double-slit experiment in various situations that appear to be counterintuitive and contradict classical notions of particles and waves. For example, if we send single electrons through the slits, they may behave as a "wave" in part of the experiment and as a "particle" in another part of the same experiment. Here we discuss the development and evaluation of a research-validated Quantum Interactive Learning Tutorial (QuILT) which makes use of an interactive simulation to improve student understanding of the double-slit experiment and strives to help students develop a good grasp of foundational issues in quantum mechanics. We discuss common student difficulties identified during the development and evaluation of the QuILT and analyze the data from the pretest and post test administered to the upper-level undergraduate and first-year physics graduate students before and after they worked on the QuILT to assess its effectiveness. These data suggest that on average, the QuILT was effective in helping students develop a more robust understanding of foundational concepts in quantum mechanics that defy classical intuition using the context of the double-slit experiment. Moreover, upper-level undergraduates outperformed physics graduate students on the post test. One possible reason for this difference in performance may be the level of student engagement with the QuILT due to the grade incentive. In the undergraduate course, the post test was graded for correctness while in the graduate course, it was only graded for completeness.

  20. Formating double layer mechanism by electric charged particle stream in plasma

    NASA Astrophysics Data System (ADS)

    Shan-jun, Ma; Qian-li, Yang; Xiao-qing, Li

    1998-08-01

    In this paper, two-fluid equations have been solved after having considered magnetic field generated by charged particle stream. Finally, the distribution of electric field Ez(z, r) and its growth rate γ in plasma have been obtained. From the expression of Ez(z, r) it can be known that the double layer has been formed. With the increase of disturbance γ will be larger, and finally this will result in the interruption of electric current and occurrence of burst.

  1. Fabrication of double-aperture hololens imaging system: application to mechanics

    NASA Astrophysics Data System (ADS)

    Yadav, H. L.; Kumari, Neelam; Bhushan, Ravi; Mallick, Anshuman; Gupta, B. N.

    2004-06-01

    Duffy suggested the use of double-aperture imaging system for the measurement of in-plane displacement component. In this arrangement, twin apertures are placed symmetrically over the imaging lens. This imaging system is used in speckle metrology to measure component of displacement parallel to the line joining the two apertures. The imaging lens used in such configuration need not be diffraction limited over the entire lens aperture, but only over the two small areas encompassed by the two apertures. In present work, compact holographic lenses have been used to generate the two apertures of Duffy's double-aperture interferometer. This imaging system has been used in speckle metrology to measure crack mouth opening displacement (CMOD) in an aluminium beam specimen having central edge crack subjected to three point bending. Experimental results are in good agreement with theoretical predictions. Present experimental investigation reveals that compact holographic lenses can be used advantageously to generate apertures of double-aperture speckle interferometer for its use in the measurement of in-plane displacement component.

  2. Determination of Constitutive Equation for Thermo-mechanical Processing of INCONEL 718 Through Double Multivariate Nonlinear Regression Analysis

    NASA Astrophysics Data System (ADS)

    Hussain, Mirza Zahid; Li, Fuguo; Wang, Jing; Yuan, Zhanwei; Li, Pan; Wu, Tao

    2015-07-01

    The present study comprises the determination of constitutive relationship for thermo-mechanical processing of INCONEL 718 through double multivariate nonlinear regression, a newly developed approach which not only considers the effect of strain, strain rate, and temperature on flow stress but also explains the interaction effect of these thermo-mechanical parameters on flow behavior of the alloy. Hot isothermal compression experiments were performed on Gleeble-3500 thermo-mechanical testing machine in the temperature range of 1153 to 1333 K within the strain rate range of 0.001 to 10 s-1. The deformation behavior of INCONEL 718 is analyzed and summarized by establishing the high temperature deformation constitutive equation. The calculated correlation coefficient ( R) and average absolute relative error ( AARE) underline the precision of proposed constitutive model.

  3. Elucidating double aggregation mechanisms in the morphology optimization of diketopyrrolopyrrole-based narrow bandgap polymer solar cells.

    PubMed

    Gao, Jing; Chen, Wei; Dou, Letian; Chen, Chun-Chao; Chang, Wei-Hsuan; Liu, Yongsheng; Li, Gang; Yang, Yang

    2014-05-21

    The power conversion efficiency (PCE) of a DPP-based polymer solar cell is significantly improved by using DIO or DCB as processing additives. The discovery that DCB outperforms DIO with a significantly wider solvent mixture operation window suggests different optimization mechanisms. Although both solvent mixture systems involve double aggregation processes, including a similar solution-to-film aggregation, however, two distinct solution-stage aggregations are observed: relatively amorphous polymer aggregates form in the CF-DIO solution, while more crystalline polymer aggregates form in CF-DCB solution.

  4. Double proton transfer mechanism in the adenine-uracil base pair and spontaneous mutation in RNA duplex

    NASA Astrophysics Data System (ADS)

    Cerón-Carrasco, José P.; Requena, Alberto; Perpète, Eric A.; Michaux, Catherine; Jacquemin, Denis

    2009-12-01

    We study the mechanism of double proton transfer (DPT) in the adenine-uracil (AU) base pair, both in gas phase and under the influence of surrounding water molecules. According to our ab initio calculations, no stable proton transfer product exists in gas phase, while in solution, the DPT process may occur only through the catalysis of water molecules. Nevertheless, a thermodynamic analysis confirms that AU does not contribute to spontaneous mutation in RNA duplex, and thus guanine-cytosine (GC) would be the only base pair contributing to spontaneous mutation.

  5. The unexpected mechanism of carbonyl hydrosilylation catalyzed by (Cp)(ArN[double bond, length as m-dash])Mo(H)(PMe(3)).

    PubMed

    Shirobokov, Oleg G; Gorelsky, Serge I; Simionescu, Razvan; Kuzmina, Lyudmila G; Nikonov, Georgii I

    2010-11-07

    Complex (Cp)(ArN[double bond, length as m-dash])Mo(H)(PMe(3)) (2, Ar = 2,6-diisopropylphenyl) catalyzes the hydrosilylation of carbonyls by an unexpected associative mechanism. Complex 2 also reacts with PhSiH(3) by a σ-bond metathesis mechanism to give the silyl derivative (Cp)(ArN[double bond, length as m-dash])Mo(SiH(2)Ph)(PMe(3)).

  6. Mechanisms of photo double ionization of helium by 530 eV photons.

    PubMed

    Knapp, A; Kheifets, A; Bray, I; Weber, Th; Landers, A L; Schössler, S; Jahnke, T; Nickles, J; Kammer, S; Jagutzki, O; Schmidt, L Ph H; Osipov, T; Rösch, J; Prior, M H; Schmidt-Böcking, H; Cocke, C L; Dörner, R

    2002-07-15

    We have measured fully differential cross sections for photo double ionization of helium 450 eV above the threshold. We have found an extremely asymmetric energy sharing between the photoelectrons and an angular asymmetry parameter beta approximately 2 and beta approximately 0 for the fast and slow electrons, respectively. The electron angular distributions show a dominance of the shakeoff for 2 eV electrons and clear evidence of an inelastic electron-electron scattering at an electron energy of 30 eV. The data are in excellent agreement with convergent close-coupling calculations.

  7. A fully coupled Thermo-Hydro-Mechanical Double Porosity Formulation for Modeling Multiphysics Problems in Geological Media

    NASA Astrophysics Data System (ADS)

    Sanchez, M. J.; Gens, A.; Jarecki, Z.; Olivella, S.

    2012-12-01

    This work presents a coupled Thermo-Hydro-Mechanical (THM) formulation developed to handle multiphysic problems in porous media with two dominant void levels. The proposed framework assumes the presence of two porous media linked through a mass transfer term between them. In many cases, the use of a double porosity formulation is more realistic because it is possible to take explicitly into account the different physical phenomena that take place in each void level, and also their mutual interactions. The formulation is especially suitable for cases in which the material exhibits a strong coupling between the mechanical and the hydraulic problem in both media. The problem is approached using a multi-phase, multi-species formulation that expresses mathematically the main coupled thermo-hydro-mechanical phenomena in terms of: balance equations, constitutive equations and equilibrium restrictions. In its more general form, the proposed approach allows the consideration of multiphase flow in the two pore levels coupled with the mechanical problem. The formulation presented is quite open and general, and able to incorporate different constitutive laws for each basic structural level considered; for the mechanical, hydraulic and thermal problems. The double structure formulation has been implemented in the finite element program CODE_BRIGHT and it has been used to analyze a variety of engineering problems associated with the design of radioactive waste disposal in deep geological media and petroleum engineering problems. This work presents two case studies; one is related to oil production in a heterogeneous reservoir, and the other case focuses on the analysis of a repository for nuclear waste in a clayed formation. Both cases show the potential of the proposed formation to tackle coupled multiphysics problems in porous media.

  8. Probable new type of reaction mechanism: Double. cap alpha. direct transfer process

    SciTech Connect

    Xu Shu-wei; Wu Guo-hua; Miao Rong-zhi; Han Fei

    1983-10-01

    It is assumed that /sup 8/Be consists of two ..cap alpha.. particles which are close to each other in configuration space. A spectroscopic density of /sup 8/Be cluster in the residue nuclei is then obtained, which is proportional to the square of the preformation probability of ..cap alpha.. particle at nuclear surface. Using the improved method of parametrization of EFR-DWBA overlap integral,/sup 1//sup en-dash//sup 2/ we calculate the double differential energy spectra and angular distributions of ..cap alpha.. particles for the reactions /sup 209/Bi (/sup 12/C, ..cap alpha..) /sup 217/Fr and extract the preformation probability of ..cap alpha.. particle at the surface of /sup 217/Fr nuclei from fitting the experimental data. The agreement within the range of calculation error between the preformation probabilities extracted from transfer reactions and ..cap alpha.. decay suggests that the reaction /sup 209/Bi(/sup 12/C, ..cap alpha..) /sup 217/Fr may be explained as a double ..cap alpha.. direct transfer process.

  9. Competitive bidding for health insurance contracts: lessons from the online HMO auctions.

    PubMed

    Gupta, Alok; Parente, Stephen T; Sanyal, Pallab

    2012-12-01

    Healthcare is an important social and economic component of modern society, and the effective use of information technology in this industry is critical to its success. As health insurance premiums continue to rise, competitive bidding may be useful in generating stronger price competition and lower premium costs for employers and possibly, government agencies. In this paper, we assess an endeavor by several Fortune 500 companies to reduce healthcare procurement costs for their employees by having HMOs compete in open electronic auctions. Although the auctions were successful in generating significant cost savings for the companies in the first year, i.e., 1999, they failed to replicate the success and were eventually discontinued after two more years. Over the past decade since the failed auction experiment, effective utilization of information technologies have led to significant advances in the design of complex electronic markets. Using this knowledge, and data from the auctions, we point out several shortcomings of the auction design that, we believe, led to the discontinuation of the market after three years. Based on our analysis, we propose several actionable recommendations that policy makers can use to design a sustainable electronic market for procuring health insurance.

  10. 7 CFR 29.75b - Display of baled flue-cured tobacco on auction warehouse floors in designated markets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Display of baled flue-cured tobacco on auction... AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS TOBACCO INSPECTION Regulations Mandatory Inspection § 29.75b Display of baled flue-cured tobacco on auction warehouse floors in designated...

  11. 7 CFR 29.75b - Display of baled flue-cured tobacco on auction warehouse floors in designated markets.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Display of baled flue-cured tobacco on auction... AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS TOBACCO INSPECTION Regulations Mandatory Inspection § 29.75b Display of baled flue-cured tobacco on auction warehouse floors in designated...

  12. 78 FR 68839 - Tribal Mobility Fund Phase I Auction Rescheduled for February 25, 2014; Notice of Changes to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-15

    ... COMMISSION Tribal Mobility Fund Phase I Auction Rescheduled for February 25, 2014; Notice of Changes to... single-round reverse auction that will award up to $50 million in one-time Tribal Mobility Fund Phase I... Rescheduling Public Notice, the Bureaus adopt schedule changes intended to give potential bidders and...

  13. 75 FR 28278 - Notice of amendment to Notice of Realty Action: Competitive Online Auction of Public Lands in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR...: 14X5232] Notice of amendment to Notice of Realty Action: Competitive Online Auction of Public Lands in... online auction will be conducted by the GSA. Bidders may register on the GSA Web site, https://www...

  14. 7 CFR 29.75b - Display of baled flue-cured tobacco on auction warehouse floors in designated markets.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... warehouse floors in designated markets. 29.75b Section 29.75b Agriculture Regulations of the Department of... Inspection § 29.75b Display of baled flue-cured tobacco on auction warehouse floors in designated markets. Each lot of baled flue-cured tobacco displayed for sale on auction warehouse floors shall have...

  15. Electronic Reverse Auctions: Integrating an E-Sourcing Tool into a Sales and Purchasing Cross-Course Negotiation Project

    ERIC Educational Resources Information Center

    Williams, Jacqueline A.; Dobie, Kathryn

    2011-01-01

    Electronic reverse auctions are increasingly being used by firms to improve firm financial and operational performance. The described teaching innovation serves as a model for introducing electronic reverse auctions as a central element in a comprehensive negotiation exercise involving sales management and purchasing management students. Results…

  16. 31 CFR 356.17 - How and when do I pay for securities awarded in an auction?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false How and when do I pay for securities... securities awarded in an auction? (a) General. By bidding in an auction, you agree to pay the settlement amount for any securities awarded to you. (See § 356.25.) For notes and bonds, the settlement amount may...

  17. Electronic Reverse Auctions: Integrating an E-Sourcing Tool into a Sales and Purchasing Cross-Course Negotiation Project

    ERIC Educational Resources Information Center

    Williams, Jacqueline A.; Dobie, Kathryn

    2011-01-01

    Electronic reverse auctions are increasingly being used by firms to improve firm financial and operational performance. The described teaching innovation serves as a model for introducing electronic reverse auctions as a central element in a comprehensive negotiation exercise involving sales management and purchasing management students. Results…

  18. Unconventional Tough Double-Network Hydrogels with Rapid Mechanical Recovery, Self-Healing, and Self-Gluing Properties.

    PubMed

    Jia, Haiyan; Huang, Zhangjun; Fei, Zhaofu; Dyson, Paul J; Zheng, Zhen; Wang, Xinling

    2016-11-16

    Hydrogels are polymeric materials that have a relatively high capacity for holding water. Recently, a double network (DN) technique was developed to fabricate hydrogels with a toughness comparable to rubber. The mechanical properties of DN hydrogels may be attributed to the brittle sacrificial bonding network of one hydrogel, facilitating stress dispersion, combined with ductile polymer chains of a second hydrogel. Herein, we report a novel class of tunable DN hydrogels composed of a polyurethane hydrogel and a stronger, dipole-dipole and H-bonding interaction reinforced (DHIR) hydrogel. Compared to conventional DN hydrogels, these materials show remarkable improvements in mechanical recovery, modulus, and yielding, with excellent self-healing and self-gluing properties. In addition, the new DN hydrogels exhibit excellent tensile and compression strengths and possess shape-memory properties, which make them promising for applications in engineering, biomedicine, and other domains where load bearing is required.

  19. Methotrexate intercalated layered double hydroxides with the mediation of surfactants: Mechanism exploration and bioassay study.

    PubMed

    Dai, Chao-Fan; Tian, De-Ying; Li, Shu-Ping; Li, Xiao-Dong

    2015-12-01

    Methotrexatum intercalated layered double hydroxides (MTX/LDHs) hybrids were synthesized by the co-precipitation method and three kinds of nonionic surfactants with different hydrocarbon chain lengths were used. The resulting hybrids were then characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and transmission electron microscopy (TEM). XRD and FTIR investigations manifest the successful intercalation of MTX anions into the interlayer of LDHs. TEM graphs indicate that the morphology of the hybrids changes with the variation of the chain length of the surfactants, i.e., the particles synthesized using polyethylene glycol (PEG-7) present regular disc morphology with good monodispersity, while samples with the mediation of alkyl polyglycoside (APG-14) are heavily aggregated and samples with the addition of polyvinylpyrrolidone (PVP-10) exhibit irregular branches. Furthermore, the release and bioassay experiments show that monodisperse MTX/LDHs present good controlled-release and are more efficient in the suppression of the tumor cells.

  20. Mechanical coupled vibrations in an individual double-walled carbon nanotube

    NASA Astrophysics Data System (ADS)

    Boutahir, Mourad; Rahmani, Abdelhai; Chadli, Hassan; Rahmani, Abdelali

    2016-05-01

    In this paper we calculate the Raman spectra of different double-walled carbon nanotubes (DWCNTs) by using the spectral moments method. Using a convenient Lennard-Jones expression of the van der Waals intermolecular interaction between the inner and outer tubes, the optimized structures of DWCNT are derived. We found that the C-C bond length in DWCNT is depending on the metallic (M) or semiconducting (Sc) character of the inner and outer nanotubes. We show that the radial breathing-like modes (RBLM) of DWCNT are characterized by concerted inner and outer wall motions. Comparison with Raman spectra measurements is given. Contribution to the topical issue "Materials for Energy Harvesting, Conversion and Storage (ICOME 2015) - Elected submissions", edited by Jean-Michel Nunzi, Rachid Bennacer and Mohammed El Ganaoui

  1. An investigation into the mechanics of double-sided incremental forming using finite element methods

    NASA Astrophysics Data System (ADS)

    Moser, Newell; Zhang, Zixuan; Ren, Huaqing; Ehmann, Kornel; Cao, Jian

    2016-10-01

    Double-Sided Incremental Forming (DSIF) is a developing sheet metal manufacturing process that has gained a lot of attention in recent years due to its inherent flexibility, low-overhead cost, and die-less nature. However, it can be challenging to define the tool gap so as to achieve a desired pressure through the sheet thickness since one must first predict sheet thinning. In this investigation, a novel part design is proposed which varies in-plane curvature as a function of depth. A finite element model for DSIF is developed and the strain histories in various regions are extracted. It was concluded that if the supporting tool loses contact with the sheet, localized necking can occur prior to part failure. Additionally, part geometry can have significant effects on the tool contact area which, consequently, affects the evolution of strain.

  2. Mechanisms of double-strand break repair in somatic mammalian cells

    PubMed Central

    Hartlerode, Andrea J.; Scully, Ralph

    2010-01-01

    DNA chromosomal DSBs (double-strand breaks) are potentially hazardous DNA lesions, and their accurate repair is essential for the successful maintenance and propagation of genetic information. Two major pathways have evolved to repair DSBs: HR (homologous recombination) and NHEJ (non-homologous end-joining). Depending on the context in which the break is encountered, HR and NHEJ may either compete or co-operate to fix DSBs in eukaryotic cells. Defects in either pathway are strongly associated with human disease, including immunodeficiency and cancer predisposition. Here we review the current knowledge of how NHEJ and HR are controlled in somatic mammalian cells, and discuss the role of the chromatin context in regulating each pathway. We also review evidence for both co-operation and competition between the two pathways. PMID:19772495

  3. Water promoting electron hole transport between tyrosine and cysteine in proteins via a special mechanism: double proton coupled electron transfer.

    PubMed

    Chen, Xiaohua; Ma, Guangcai; Sun, Weichao; Dai, Hongjing; Xiao, Dong; Zhang, Yanfang; Qin, Xin; Liu, Yongjun; Bu, Yuxiang

    2014-03-26

    The proton/electron transfer reactions between cysteine residue (Cys) and tyrosinyl radical (Tyr(•)) are an important step for many enzyme-catalyzed processes. On the basis of the statistical analysis of protein data bank, we designed three representative models to explore the possible proton/electron transfer mechanisms from Cys to Tyr(•) in proteins. Our ab initio calculations on simplified models and quantum mechanical/molecular mechanical (QM/MM) calculations on real protein environment reveal that the direct electron transfer between Cys and Tyr(•) is difficult to occur, but an inserted water molecule can greatly promote the proton/electron transfer reactions by a double-proton-coupled electron transfer (dPCET) mechanism. The inserted H2O plays two assistant roles in these reactions. The first one is to bridge the side chains of Tyr(•) and Cys via two hydrogen bonds, which act as the proton pathway, and the other one is to enhance the electron overlap between the lone-pair orbital of sulfur atom and the π-orbital of phenol moiety and to function as electron transfer pathway. This water-mediated dPCET mechanism may offer great help to understand the detailed electron transfer processes between Tyr and Cys residues in proteins, such as the electron transfer from Cys439 to Tyr730(•) in the class I ribonucleotide reductase.

  4. A Mathematical Model for the Detection Mechanism of DNA Double-Strand Breaks Depending on Autophosphorylation of ATM

    PubMed Central

    Mouri, Kazunari; Nacher, Jose C.; Akutsu, Tatsuya

    2009-01-01

    Background After IR stress, DNA double-strand breaks (DSBs) occur and repair proteins (RPs) bind to them, generating DSB-RP complexes (DSBCs), which results in repaired DSBs (RDSBs). In recent experimental studies, it is suggested that the ATM proteins detect these DNA lesions depending on the autophosphorylation of ATM which exists as a dimer before phosphorylation. Interestingly, the ATM proteins can work as a sensor for a small number of DSBs (approximately 18 DSBs in a cell after exposure to IR). Thus the ATM proteins amplify the small input signals based on the phosphorylation of the ATM dimer proteins. The true DSB-detection mechanism depending on ATM autophosphorylation has yet to be clarified. Methodology/Principal Findings We propose a mathematical model for the detection mechanism of DSBs by ATM. Our model includes both a DSB-repair mechanism and an ATM-phosphorylation mechanism. We model the former mechanism as a stochastic process, and obtain theoretical mean values of DSBs and DSBCs. In the latter mechanism, it is known that ATM autophosphorylates itself, and we find that the autophosphorylation induces bifurcation of the phosphorylated ATM (ATM*). The bifurcation diagram depends on the total concentration of ATM, which makes three types of steady state diagrams of ATM*: monostable, reversible bistable, and irreversible bistable. Bistability exists depending on the Hill coefficient in the equation of ATM autophosphorylation, and it emerges as the total concentration of ATM increases. Combining these two mechanisms, we find that ATM* exhibits switch-like behaviour in the presence of bistability, and the detection time after DNA damage decreases when the total concentration of ATM increases. Conclusions/Significance This work provides a mathematical model that explains the DSB-detection mechanism depending on ATM autophosphorylation. These results indicate that positive auto-regulation works both as a sensor and amplifier of small input signals. PMID

  5. A deployment mechanism for the double roll-out flexible solar array on the space telescope

    NASA Technical Reports Server (NTRS)

    Cawsey, T. R.

    1982-01-01

    A roll-out flexible array which provides more than 4 kW of power for the space telescope was developed. The Array is configured as two wings. The deployment mechanism for each wing is based on flight-proven FRUSA design. Modifications have been incorporated to accommodate an increase in size and mission requirements. The assembly and operation of the deployment mechanism are described together with environmental and functional tests results.

  6. Physical contact influences how much people pay at celebrity auctions.

    PubMed

    Newman, George E; Bloom, Paul

    2014-03-11

    Contagion is a form of magical thinking in which people believe that a person's immaterial qualities or essence can be transferred to an object through physical contact. Here we investigate how a belief in contagion influences the sale of celebrity memorabilia. Using data from three high-profile estate auctions, we find that people's expectations about the amount of physical contact between the object and the celebrity positively predicts the final bids for items that belonged to well-liked individuals (e.g., John F. Kennedy) and negatively predicts final bids for items that belonged to disliked individuals (e.g., Bernard Madoff). A follow-up experiment further suggests that these effects are driven by contagion beliefs: when asked to bid on a sweater owned by a well-liked celebrity, participants report that they would pay substantially less if it was sterilized before they received it. However, sterilization increases the amount they would pay for a sweater owned by a disliked celebrity. These studies suggest that magical thinking may still have effects in contemporary Western societies and they provide some unique demonstrations of contagion effects on real-world purchase decisions.

  7. Physical contact influences how much people pay at celebrity auctions

    PubMed Central

    Newman, George E.; Bloom, Paul

    2014-01-01

    Contagion is a form of magical thinking in which people believe that a person’s immaterial qualities or essence can be transferred to an object through physical contact. Here we investigate how a belief in contagion influences the sale of celebrity memorabilia. Using data from three high-profile estate auctions, we find that people’s expectations about the amount of physical contact between the object and the celebrity positively predicts the final bids for items that belonged to well-liked individuals (e.g., John F. Kennedy) and negatively predicts final bids for items that belonged to disliked individuals (e.g., Bernard Madoff). A follow-up experiment further suggests that these effects are driven by contagion beliefs: when asked to bid on a sweater owned by a well-liked celebrity, participants report that they would pay substantially less if it was sterilized before they received it. However, sterilization increases the amount they would pay for a sweater owned by a disliked celebrity. These studies suggest that magical thinking may still have effects in contemporary Western societies and they provide some unique demonstrations of contagion effects on real-world purchase decisions. PMID:24567388

  8. Bidding process in online auctions and winning strategy: Rate equation approach

    NASA Astrophysics Data System (ADS)

    Yang, I.; Kahng, B.

    2006-06-01

    Online auctions have expanded rapidly over the last decade and have become a fascinating new type of business or commercial transaction in this digital era. Here we introduce a master equation for the bidding process that takes place in online auctions. We find that the number of distinct bidders who bid k times up to the t th bidding progresses, called the k -frequent bidder, seems to scale as nk(t)˜tk-2.4 . The successfully transmitted bidding rate by the k -frequent bidder is likely to scale as qk(t)˜k-1.4 , independent of t for large t . This theoretical prediction is close to empirical data. These results imply that bidding at the last moment is a rational and effective strategy to win in an eBay auction.

  9. Bidding process in online auctions and winning strategy: Rate equation approach.

    PubMed

    Yang, I; Kahng, B

    2006-06-01

    Online auctions have expanded rapidly over the last decade and have become a fascinating new type of business or commercial transaction in this digital era. Here we introduce a master equation for the bidding process that takes place in online auctions. We find that the number of distinct bidders who bid k times up to the tth bidding progresses, called the k-frequent bidder, seems to scale as n(k)(t) approximately tk(-2.4). The successfully transmitted bidding rate by the k-frequent bidder is likely to scale as q(k)(t) approximately k(-1.4), independent of t for large t. This theoretical prediction is close to empirical data. These results imply that bidding at the last moment is a rational and effective strategy to win in an eBay auction.

  10. Spiral of Hatred: Social Effects in Buyer-Seller Cross-Comments Left on Internet Auctions

    NASA Astrophysics Data System (ADS)

    Nielek, Radoslaw; Wawer, Aleksander; Wierzbicki, Adam

    An auction platform is a dynamic environment where a rich variety of social effects can be observed. Most of those effects remain unnoticed or even hidden to ordinary users. The in-depth studies of such effects should allow us to identify and understand the key factors influencing users’ behaviour. The material collected from the biggest Polish auction house has been analyzed. NLP algorithms were applied to extract sentiment-related content from collected comments. Emotional distance between negative, neutral and positive comments has been calculated. The obtained results confirm the existence of the spiral-of-hatred effect but also indicate that much more complex patterns of mutual relations between sellers and buyers exist. The last section contains a several suggestions which can prove useful to improve trustworthiness of users’ reports and security of an auction platform in general.

  11. The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End Joining Pathway

    PubMed Central

    Lieber, Michael R.

    2011-01-01

    Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous recombination and nonhomologous DNA end joining (NHEJ). The diverse causes of DSBs result in a diverse chemistry of DNA ends that must be repaired. Across NHEJ evolution, the enzymes of the NHEJ pathway exhibit a remarkable degree of structural tolerance in the range of DNA end substrate configurations upon which they can act. In vertebrate cells, the nuclease, polymerases and ligase of NHEJ are the most mechanistically flexible and multifunctional enzymes in each of their classes. Unlike repair pathways for more defined lesions, NHEJ repair enzymes act iteratively, act in any order, and can function independently of one another at each of the two DNA ends being joined. NHEJ is critical not only for the repair of pathologic DSBs as in chromosomal translocations, but also for the repair of physiologic DSBs created during V(D)J recombination and class switch recombination. Therefore, patients lacking normal NHEJ are not only sensitive to ionizing radiation, but also severely immunodeficient. PMID:20192759

  12. Heat transfer augmentation in double pipe heat exchanger using mechanical turbulators

    NASA Astrophysics Data System (ADS)

    Kamboj, Kushal; Singh, Gurjeet; Sharma, Rohit; Panchal, Dilbagh; Hira, Jaspreet

    2017-02-01

    The work presented here focuses on heat transfer augmentation by means of divergent-convergent spring turbulator (the enhancement device). Aim of the present work is to find such an optimum pitch at which the augmentation in heat transfer is maximum and the amount of power consumption is minimum, so that an economic design can be created with maximum thermal efficiency. So, the concept of pitch variation is introduced, which is defined as the horizontal distance between two consecutive turbulators. It describes that, the lesser is the pitch the more number of turbulators that can be inserted in inner pipe of double pipe heat exchanger, hence more will be the friction factor. This physics increases convective ability of the heat transfer process from the surface of inner pipe. There is a certain limit to which a pitch can be decreased, lesser the pitch the more the pressure drop and friction factor and hence the more will be the pumping power requirement to maintain a desired mass flow rate of hot water. Analysis of thermal factors such as Nusselts number, friction factor, with different pitches of divergent convergent spring turbulators of circular cross-section 15, 10, and 5 cm at Reynolds's number ranging between 9000 < Re < 40,000 is done graphically.

  13. Measuring electrical and mechanical properties of red blood cells with a double optical tweezers

    NASA Astrophysics Data System (ADS)

    Fontes, Adriana; Fernandes, Heloise P.; Barjas-Castro, Maria L.; de Thomaz, André A.; Pozzo, Liliana d. Y.; Barbosa, Luiz C.; Cesar, Carlos L.

    2006-08-01

    The fluid lipid bilayer viscoelastic membrane of red blood cells (RBC) contains antigen glycolproteins and proteins which can interact with antibodies to cause cell agglutination. This is the basis of most of the immunohematologic tests in blood banks and the identification of the antibodies against the erythrocyte antigens is of fundamental importance for transfusional routines. The negative charges of the RBCs creates a repulsive electric (zeta) potential between the cells and prevents their aggregation in the blood stream. The first counterions cloud strongly binded moving together with the RBC is called the compact layer. This report proposes the use of a double optical tweezers for a new procedure for measuring: (1) the apparent membrane viscosity, (2) the cell adhesion, (3) the zeta potential and (4) the compact layer's size of the charges formed around the cell in the electrolytic solution. To measure the membrane viscosity we trapped silica beads strongly attached to agglutinated RBCs and measured the force to slide one RBC over the other as a function of the relative velocity. The RBC adhesion was measured by slowly displacing two RBCs apart until the disagglutination happens. The compact layer's size was measured using the force on the silica bead attached to a single RBC in response to an applied voltage and the zeta potential was obtained by measuring the terminal velocity after releasing the RBC from the optical trap at the last applied voltage. We believe that the methodology here proposed can improve the methods of diagnosis in blood banks.

  14. Experimental investigation of combustion mechanisms of kerosene-fueled scramjet engines with double-cavity flameholders

    NASA Astrophysics Data System (ADS)

    Pan, Yu; Tan, Jian-Guo; Liang, Jian-Han; Liu, Wei-Dong; Wang, Zhen-Guo

    2011-12-01

    A scramjet combustor with double cavitybased flameholders was experimentally studied in a directconnected test bed with the inflow conditions of M = 2.64, P t = 1.84MPa, T t = 1 300 K. Successful ignition and self-sustained combustion with room temperature kerosene was achieved using pilot hydrogen, and kerosene was vertically injected into the combustor through 4×ϕ0.5mm holes mounted on the wall. For different equivalence ratios and different injection schemes with both tandem cavities and parallel cavities, flow fields were obtained and compared using a high speed camera and a Schlieren system. Results revealed that the combustor inside the flow field was greatly influenced by the cavity installation scheme, cavities in tandem easily to form a single side flame distribution, and cavities in parallel are more likely to form a joint flame, forming a choked combustion mode. The supersonic combustion flame was a kind of diffusion flame and there were two kinds of combustion modes. In the unchoked combustion mode, both subsonic and supersonic combustion regions existed. While in the choked mode, the combustion region was fully subsonic with strong shock propagating upstream. Results also showed that there was a balance point between the boundary separation and shock enhanced combustion, depending on the intensity of heat release.

  15. Sorption mechanisms of arsenate on Mg-Fe layered double hydroxides: A combination of adsorption modeling and solid state analysis.

    PubMed

    Hudcová, Barbora; Veselská, Veronika; Filip, Jan; Číhalová, Sylva; Komárek, Michael

    2017-02-01

    Layered double hydroxides have been proposed as effective sorbents for As(V), but studies investigating adsorption mechanisms usually lack a comprehensive mechanistic/modeling approach. In this work, we propose coupling surface complexation modeling with various spectroscopic techniques. To this end, a series of batch experiments at different pH values were performed. Kinetic data were well fitted by a pseudo-second order kinetic model, and the equilibrium data were fitted by the Freundlich model. Moreover, the pH-dependent As(V) sorption data were satisfactorily fitted by a diffuse layer model, which described the formation of >SOAsO3H(-) monodentate and >(SO)2AsO2(-) bidentate inner-sphere complexes (">S" represents a crystallographically-bound group on the surface). Additionally, XPS analyses confirmed the adsorption mechanisms. The sorption mechanisms were affected by anion exchange, which was responsible for the formation of outer sphere complexes, as identified by XRD and FTIR analyses. Furthermore, a homogenous distribution of As(V) was determined by HR-TEM with elemental mapping. Using low-temperature Mössbauer spectroscopy on isotope (57)Fe, a slight shift of the hyperfine parameters towards higher values following As(V) sorption was measured, indicating a higher degree of structural disorder. In general, mechanistic adsorption modeling coupled with solid state analyses presents a powerful approach for investigating the adsorption mechanism of As(V) on Mg-Fe LDH or other sorbents.

  16. Mechanical Properties of Double-Layer and Graded Composite Coatings of YSZ Obtained by Atmospheric Plasma Spraying

    NASA Astrophysics Data System (ADS)

    Carpio, Pablo; Rayón, Emilio; Salvador, María Dolores; Lusvarghi, Luca; Sánchez, Enrique

    2016-04-01

    Double-layer and graded composite coatings of yttria-stabilized zirconia were sprayed on metallic substrates by atmospheric plasma spray. The coating architecture was built up by combining two different feedstocks: one micro- and one nanostructured. Microstructural features and mechanical properties (hardness and elastic modulus) of the coatings were determined by FE-SEM microscopy and nanoindentation technique, respectively. Additional adherence and scratch tests were carried out in order to assess the failure mechanisms occurring between the layers comprising the composites. Microstructural inspection of the coatings confirms the two-zone microstructure. This bimodal microstructure which is exclusive of the layer obtained from the nanostructured feedstock negatively affects the mechanical properties of the whole composite. Nanoindentation tests suitably reproduce the evolution of mechanical properties through coatings thickness on the basis of the position and/or amount of nanostructured feedstock used in the depositing layer. Adhesion and scratch tests show the negative effect on the coating adhesion of layer obtained from the nanostructured feedstock when this layer is deposited on the bond coat. Thus, the poor integrity of this layer results in lower normal stresses required to delaminate the coating in the adhesion test as well as minor critical load registered by using the scratch test.

  17. Double-Negative Mechanical Metamaterials Displaying Simultaneous Negative Stiffness and Negative Poisson's Ratio Properties.

    PubMed

    Hewage, Trishan A M; Alderson, Kim L; Alderson, Andrew; Scarpa, Fabrizio

    2016-12-01

    A scalable mechanical metamaterial simultaneously displaying negative stiffness and negative Poisson's ratio responses is presented. Interlocking hexagonal subunit assemblies containing 3 alternative embedded negative stiffness (NS) element types display Poisson's ratio values of -1 and NS values over two orders of magnitude (-1.4 N mm(-1) to -160 N mm(-1) ), in good agreement with model predictions.

  18. Practical Application of Principle-Agent and Auction Theory: A Contracting Guide

    DTIC Science & Technology

    2015-05-01

    Capt Will Griffin C1C Ryan Holler C1C Jimmy Manuel C1C Ryan McVay Practical Application of Principle-Agent and Auction Theory: A Contracting... Auction Theory: A Contracting Guide 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER...Statement of the Problem  The DOD holds an inferior position when bargaining with the private sector (known budget). This creates inefficiencies in

  19. A new quantum sealed-bid auction protocol with secret order in post-confirmation

    NASA Astrophysics Data System (ADS)

    Wang, Jing-Tao; Chen, Xiu-Bo; Xu, Gang; Meng, Xiang-Hua; Yang, Yi-Xian

    2015-10-01

    A new security protocol for quantum sealed-bid auction is proposed to resist the collusion attack from some malicious bidders. The most significant feature of this protocol is that bidders prepare their particles with secret order in post-confirmation for encoding bids. In addition, a new theorem and its proof are given based on the theory of combinatorial mathematics, which can be used as evaluation criteria for the collusion attack. It is shown that the new protocol is immune to the collusion attack and meets the demand for a secure auction. Compared with those previous protocols, the security, efficiency and availability of the proposed protocol are largely improved.

  20. Folding mechanism of a multiple independently-folding domain protein: double B domain of protein A.

    PubMed

    Arora, Pooja; Hammes, Gordon G; Oas, Terrence G

    2006-10-10

    The antibody binding properties of staphylococcal protein A (SpA) can be attributed to the presence of five highly homologous domains (E, D, A, B, and C). Although the folding of the B domain of protein A (BdpA) is well-characterized, the folding behavior of this domain in the context of full-length SpA in the cell remains unexplored. The sequence of the B domain is 89 and 91% identical to those of domains A and C, respectively. We have fused B domain sequences (BBdpA) as a close approximation of the A-B or B-C portion of SpA. Circular dichroism and fluorescence-detected denaturation curves of BBdpA are experimentally indistinguishable from those of BdpA. The rate constants for folding and unfolding from NMR line shape analysis for the single- and double-domain proteins are the same within experimental uncertainties (+/-20%). These results support the designation of SpA as a multiple independently-folding domain (MIFD) protein. We develop a mathematical model that describes the folding thermodynamics and kinetics of MIFD proteins. The model depicts MIFD protein folding and unfolding as a parallel network and explicitly calculates the flux through all parallel pathways. These fluxes are combined to give a complete description of the global thermodynamics and kinetics of the folding and unfolding of MIFD proteins. The global rates for complete folding and unfolding of a MIFD protein and those of the individual domains depend on the stability of the protein. We show that the global unfolding rate of a MIFD protein may be many orders of magnitude slower than that of the constituent domains.

  1. Studying red blood cell agglutination by measuring electrical and mechanical properties with a double optical tweezers

    NASA Astrophysics Data System (ADS)

    Fontes, Adriana; Fernandes, Heloise P.; de Thomaz, André A.; Barbosa, Luiz C.; Barjas-Castro, Maria L.; Cesar, Carlos L.

    2007-07-01

    The red blood cell (RBC) viscoelastic membrane contains proteins and glycolproteins embedded in, or attached, to a fluid lipid bilayer and are negatively charged, which creates a repulsive electric (zeta) potential between the cells and prevents their aggregation in the blood stream. The basis of the immunohematologic tests is the interaction between antigens and antibodies that causes hemagglutination. The identification of antibodies and antigens is of fundamental importance for the transfusional routine. This agglutination is induced by decreasing the zeta-potential through the introduction of artificial potential substances. This report proposes the use of the optical tweezers to measure the membrane viscosity, the cell adhesion, the zeta-potential and the size of the double layer of charges (CLC) formed around the cell in an electrolytic solution. The adhesion was quantified by slowly displacing two RBCs apart until the disagglutination. The CLC was measured using the force on the bead attached to a single RBC in response to an applied voltage. The zeta-potential was obtained by measuring the terminal velocity after releasing the RBC from the optical trap at the last applied voltage. For the membrane viscosity experiment, we trapped a bead attached to RBCs and measured the force to slide one RBC over the other as a function of the relative velocity. After we tested the methodology, we performed measurements using antibody and potential substances. We observed that this experiment can provide information about cell agglutination that helps to improve the tests usually performed in blood banks. We also believe that this methodology can be applied for measurements of zeta-potentials in other kind of samples.

  2. Hydroxy double salts loaded with bioactive ions: Synthesis, intercalation mechanisms, and functional performance

    NASA Astrophysics Data System (ADS)

    Y. A. Kaassis, Abdessamad; Xu, Si-Min; Guan, Shanyue; Evans, David G.; Wei, Min; Williams, Gareth R.

    2016-06-01

    The intercalation of the anions of diclofenac (Dic), naproxen (Nap), and valproic acid (Val) into three hydroxy double salts (HDSs) has been explored in this work. Experiments were performed with [Co1.2Zn3.8(OH)8](NO3)2·2H2O (CoZn-NO3), [Ni2Zn3(OH)8](NO3)2·2H2O (NiZn-NO3) and [Zn5(OH)8](NO3)2·2H2O (Zn-NO3). It proved possible to intercalate diclofenac and naproxen into all three HDSs. In contrast, Val could be intercalated into CoZn-NO3 but when it was reacted with Zn-NO3 the HDS structure was destroyed, and the product comprised ZnO. Successful intercalation was verified by X-ray diffraction, IR spectroscopy, and elemental microanalysis. Molecular dynamics simulations showed the Dic and Nap ions to arrange themselves in an "X" shape in the interlayer space, forming a bilayer. Val was found to adopt a position with its aliphatic groups parallel to the HDS layer, again in a bilayer. In situ time resolved X-ray diffraction experiments revealed that intercalation of Dic and Nap into CoZn-NO3 and Zn-NO3 is mechanistically complex, with a number of intermediate phases observed. In contrast, the intercalation of all three guests into NiZn-NO3 and of Val into CoZn-NO3 are simple one step reactions proceeding directly from the starting material to the product. The HDS-drug composites were found to have sustained release profiles.

  3. Double beat-wave mechanism to keep particle in phase with accelerating plasma wave

    SciTech Connect

    Csonka, P.L.

    1985-01-01

    Two mechanisms are described by which the phase matching between accelerated particle and accelerating plasma wave in a plasma beat-wave accelerator can be maintained indefinitely. (1) Interference between two beat-waves to cancel (a) the fields in the interfering electromagnetic waves, and (b) electron oscillations which would otherwise be set up by those waves. (2) Alternating plasma density used in conjunction with one or two beat-waves.

  4. Mechanism of single- and double-sided inhibition of dual topology fluoride channels by synthetic monobodies.

    PubMed

    Turman, Daniel L; Stockbridge, Randy B

    2017-04-03

    The Fluc family of proteins comprises small, electrodiffusive fluoride channels, which prevent accumulation of toxic F(-) ions in microorganisms. Recent crystal structures have confirmed their unusual architecture, in which a pair of antiparallel subunits convenes to form a dimer with a twofold symmetry axis parallel to the plane of the membrane. These structures have also revealed the interactions between Fluc channels and several different fibronectin domain monobodies that inhibit Fluc-mediated F(-) currents; in all structures, each channel binds to two monobodies symmetrically, one on either side of the membrane. However, these structures do not reveal the mechanism of monobody inhibition. Moreover, the results appear to diverge from a recent electrophysiological study indicating that monobody binding is negatively cooperative; that is, a bound monobody on one side of a Fluc channel decreases the affinity of an oppositely bound monobody by ∼10-fold. In this study, we reconcile these observations by probing the mechanism of monobody binding and its negative cooperativity using electrophysiological experiments in planar lipid bilayers. Our results indicate that monobody inhibition occurs via a pore-blocking mechanism and that negative cooperativity arises from electrostatic repulsion between the oppositely bound monobodies. A single glutamate residue, on a loop of the monobody that extends into the channel interior, is responsible for negatively cooperative binding. This glutamate side chain also confers voltage dependence and sensitivity to the concentration of trans-F(-) ion to monobody binding. Neutralization by mutation to glutamine abolishes these electrostatic effects. Monobodies that are amenable to cocrystallization with Fluc channels lack an analogous negatively charged side chain and bind independently to opposite sides of the channel. Thus, this work reveals the source of voltage dependence and negative cooperativity of monobody binding to Fluc

  5. Analysis on strength and stiffness of double-deck plates filter system of mechanical water treatment plant

    NASA Astrophysics Data System (ADS)

    Feng, De-zhen; Yu, Qi-qi

    2017-01-01

    Domestic water treatment is a very important technology field. Now, mechanical water treatment technology is getting wide use in production. In the process of life water treatment, filter process is a very important step. In this paper, the strength and deformation of double-deck plates filter system which includes upper filter plate, lower filter plate and reinforced ribs were analyzed with ANSYS and useful results were got. Through the analysis on strength and deformation, the paper found the advantages and disadvantages of production and design of filter systems. After analyzing and comparing the stresses and deformations of several different design schemes, the paper provided the optimized design plan of filter system which can satisfy the strength need and decrease the creep deformation of plastic filter plates.

  6. Double frequency absorption induced by Al-Si Schottky barrier potential and mechanism of two-photon response

    NASA Astrophysics Data System (ADS)

    Zhang, Xiaoting; Gao, Yanjun; Chen, Zhanguo; Jia, Gang; Liu, Yunlong; Liu, Xiuhuan; Zh, Yuhong

    2006-01-01

    By observing two-photon response and anisotropy of the light-induced voltage in Si-Al Schottky barrier potential of the Si MSM (Metal-Semiconductor-Metal) planar structure two-photon response optical detector. It is certified from the experimental and theoretical analysis that the built-in electric field generated by the Schottky barrier potential will induce the phenomena of optical rectification in Si photodiode. Thus, it is deduced that there must be double-frequency absorption (DFA) caused by phase-mismatch in the mechanism of two-photon response of Si photodiode. If the intensity of the built-in electric field is strong enough, the DFA will be the main feature of the two-photon response.

  7. Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell

    PubMed Central

    2014-01-01

    Introduction Ventilator-induced lung injury (VILI) impacts clinical outcomes in acute respiratory distress syndrome (ARDS), which is characterized by neutrophil-mediated inflammation and loss of alveolar barrier function. Recent epidemiological studies suggest that smoking may be a risk factor for the development of ARDS. Because alveolar type II cells are central to maintaining the alveolar epithelial barrier during oxidative stress, mediated in part by neutrophilic inflammation and mechanical ventilation, we hypothesized that exposure to cigarette smoke and mechanical strain have interactive effects leading to the activation of and damage to alveolar type II cells. Methods To determine if cigarette smoke increases susceptibility to VILI in vivo, a clinically relevant rat model was established. Rats were exposed to three research cigarettes per day for two weeks. After this period, some rats were mechanically ventilated for 4 hours. Bronchoalveolar lavage (BAL) and differential cell count was done and alveolar type II cells were isolated. Proteomic analysis was performed on the isolated alveolar type II cells to discover alterations in cellular pathways at the protein level that might contribute to injury. Effects on levels of proteins in pathways associated with innate immunity, oxidative stress and apoptosis were evaluated in alveolar type II cell lysates by enzyme-linked immunosorbent assay. Statistical comparisons were performed by t-tests, and the results were corrected for multiple comparisons using the false discovery rate. Results Tobacco smoke exposure increased airspace neutrophil influx in response to mechanical ventilation. The combined exposure to cigarette smoke and mechanical ventilation significantly increased BAL neutrophil count and protein content. Neutrophils were significantly higher after smoke exposure and ventilation than after ventilation alone. DNA fragments were significantly elevated in alveolar type II cells. Smoke exposure did not

  8. Study of Electrical Conduction Mechanism of Organic Double-Layer Diode Using Electric Field Induced Optical Second Harmonic Generation Measurement.

    PubMed

    Nishi, Shohei; Taguchi, Dai; Manaka, Takaaki; Iwamoto, Mitsumasa

    2016-04-01

    By using electric field induced optical second harmonic generation (EFISHG) and current voltage (I-V) measurements, we studied the electrical transport mechanism of organic double-layer diodes with a structure of Au/N, N'-di-[(1-naphthyl)-N, N'-diphenyl]-(1,1'-biphenyl)-4,4'-diamine (a-NPD)/poly(methyl methacrylate) (PMMA)/indium zinc oxide (IZO). Here the α-NPD is a carrier transport layer and the PMMA is an electrical insulating layer. The current level was very low, but the I-V characteristics showed a rectifying behavior. The EFISHG measurement selectively and directly probed the electric field across the α-NPD layer, and showed that the electric field across the a-NPD layer is completely relaxed owing to the charge accumulation at the a-NPD/PMMA interface in the region V > 0, whereas the carrier accumulation was not significant in the region V < 0. On the basis of these experimental results, we proposed a model of the rectification. Further, by coupling the I-V characteristics with the EFISHG measurement, the I-V characteristics of the diodes were well converted into the current-electric field (I-E) characteristics of the α-NPD layer and the PMMA layer. The I-E characteristics suggested the Schottky-type conduction governs the carrier transport. We conclude that the I-V measurement coupled with the EFISHG measurement is very useful to study carrier transport mechanism of the organic double-layer diodes.

  9. Double torsion fracture mechanics testing of shales under chemically reactive conditions

    NASA Astrophysics Data System (ADS)

    Chen, X.; Callahan, O. A.; Holder, J. T.; Olson, J. E.; Eichhubl, P.

    2015-12-01

    Fracture properties of shales is vital for applications such as shale and tight gas development, and seal performance of carbon storage reservoirs. We analyze the fracture behavior from samples of Marcellus, Woodford, and Mancos shales using double-torsion (DT) load relaxation fracture tests. The DT test allows the determination of mode-I fracture toughness (KIC), subcritical crack growth index (SCI), and the stress-intensity factor vs crack velocity (K-V) curves. Samples are tested at ambient air and aqueous conditions with variable ionic concentrations of NaCl and CaCl2, and temperatures up to 70 to determine the effects of chemical/environmental conditions on fracture. Under ambient air condition, KIC determined from DT tests is 1.51±0.32, 0.85±0.25, 1.08±0.17 MPam1/2 for Marcellus, Woodford, and Mancos shales, respectively. Tests under water showed considerable change of KIC compared to ambient condition, with 10.6% increase for Marcellus, 36.5% decrease for Woodford, and 6.7% decrease for Mancos shales. SCI under ambient air condition is between 56 and 80 for the shales tested. The presence of water results in a significant reduction of the SCI from 70% to 85% compared to air condition. Tests under chemically reactive solutions are currently being performed with temperature control. K-V curves under ambient air conditions are linear with stable SCI throughout the load-relaxation period. However, tests conducted under water result in an initial cracking period with SCI values comparable to ambient air tests, which then gradually transition into stable but significantly lower SCI values of 10-20. The non-linear K-V curves reveal that crack propagation in shales is initially limited by the transport of chemical agents due to their low permeability. Only after the initial cracking do interactions at the crack tip lead to cracking controlled by faster stress corrosion reactions. The decrease of SCI in water indicates higher crack propagation velocity due to

  10. Nonsequential Double Ionization of Atoms in Strong Laser Field: Identifying the Mechanisms behind the Correlated-Electron Momentum Spectra

    NASA Astrophysics Data System (ADS)

    Ye, Difa; Fu, Libin; Liu, Jie

    Within the strong-field physics community, there has been increasing interest on nonsequential double ionization (NSDI) induced by electron-electron (e-e) correlation. A large variety of novel phenomena has been revealed in experiments during the past decades. However, the theoretical understanding and interpretation of this process is still far from being complete. The most accurate simulation, i.e. the exact solution of the time-dependent Schrödinger equation (TDSE) for two electrons in a laser field is computationally expensive. In order to overcome the difficulty, we proposed a feasible semiclassical model, in which we treat the tunneling ionization of the outmost electron quantum mechanically according to the ADK theory, sample the inner electron from microcanonical distribution and then evolve the two electrons with Newton's equations. With this model, we have successfully explained various NSDI phenomena, including the excessive DI yield, the energy spectra and angular distribution of photoelectrons. Very recently, it is adopted to reveal the physical mechanisms behind the fingerlike structure in the correlated electron momentum spectra, the unexpected correlation-anticorrelation transition close to the recollision threshold, and the anomalous NSDI of alkaline-earth-metal atoms in circularly polarized field. The obvious advantage of our model is that it gives time-resolved insights into the complex dynamics of NSDI, from the turn-on of the laser field to the final escape of the electrons, thus allowing us to disentangle and thoroughly analyze the underlying physical mechanisms.

  11. Mutant poisoning demonstrates a nonsequential mechanism for digestion of double-stranded DNA by λ exonuclease trimers.

    PubMed

    Pan, Xinlei; Yan, Jing; Patel, Aalapi; Wysocki, Vicki H; Bell, Charles E

    2015-01-27

    λ Exonuclease (λexo) is a highly processive 5'-3' exonuclease that binds double-stranded DNA (dsDNA) ends and digests the 5'-strand into mononucleotides. The enzyme forms a toroidal homotrimer with a central tapered channel for tracking along the DNA. During catalysis, dsDNA enters the open end of the channel, and the 5'-strand is digested at one of the three active sites. It is currently not known if λexo uses a sequential mechanism, in which the DNA moves from one active site to the next around the trimer for each round of catalysis or a nonsequential mechanism, in which the DNA locks onto a single active site for multiple rounds. To understand how λexo uses its three active sites, we used a mutant poisoning approach, in which a 6xHis-tagged K131A inactive mutant of λexo was mixed with untagged wild type (WT) to form hybrid trimers. Nickel-spin pull-down analysis confirmed complete subunit exchange after 1 h at 37 °C. Exonuclease assays revealed an approximately linear decrease in activity with increasing fraction of mutant, as expected for a nonsequential mechanism. By fitting the observed rates of digestion to a simple mathematical model, the individual rates of the two hybrid species of trimer were determined. This analysis showed that trimers containing only one or two WT subunits contribute significantly to the observed activity, in further agreement with a nonsequential mechanism. Finally, purification of hybrid trimer mixtures by Ni-spin chromatography, to remove the contribution from fully WT trimers, also resulted in significant levels of activity, again consistent with a nonsequential mechanism.

  12. Studies on the Dynamic Mechanical Properties of the Composite Modified Double-Base Propellant,

    DTIC Science & Technology

    1986-05-29

    between the DII and PVC composite propellants asid depend on its binder system, and that the CMDB propellant has the spec;fic properties of both higher...the mechanical properties of cMDB propellants, is discussed by using a viscoelastometer. 1. Samples and Experimental Method 1.1 Samples The detailed...r -rr~rw.w w - W ’S - -’ -fj -9f W 2 W W- W- W- 1 From Figure 3.3 it is seen that the impulsive strength of CMDB propellant increases in two stages

  13. Separation mechanism for double cylinder with shrink fitting system used for ceramics conveying rollers

    NASA Astrophysics Data System (ADS)

    Li, Wenbin; Sakai, Hiromasa; Harada, Shota; Takase, Yasushi; Noda, Nao-Aki

    2011-09-01

    Steel conveying rollers used in hot rolling mills must be exchanged frequently at great cost because hot conveyed strips induce wear and deterioration on the surface of roller in short periods. In previous studies, new roller structure was considered which has a ceramics sleeve connected with two steel shafts at both ends by shrink fitting. Here, although the ceramics sleeve can be used for many years, the steel shafts sometimes have to be exchanged for maintenance and reconstruction under the corrosive atmosphere. Since the thermal expansion coefficient of steel is about five times larger than that of ceramics, it is necessary to investigate how to separate the shrink fitting system by heating outside of sleeve and cooling inside of the shaft. Although how to separate the real roller has been discussed in the previous study, the separation mechanism has not been clarified yet. Therefore, in this study, several types of more fundamental models are investigated to understand the separation mechanism of real roller by the application of the finite element method. The results may be useful for designs of new rollers.

  14. A double-ratchet mechanism of transcription elongation and its control

    NASA Astrophysics Data System (ADS)

    Ruckenstein, Andrei

    2005-03-01

    Transcription, the process by which the genetic information encoded in DNA is transferred into RNA, is the first step in gene expression and it is the step at which most regulation occurs. A detailed understanding of the structural and mechanistic aspects of each step of transcription (initiation, elongation, termination and regulation) is one of the holy grails of biology. Here we characterize the motion of RNA polymerase (RNAP), the multi-subunit molecular motor that carries out the transcription process, during the elongation stage. We argue that during elongation RNAP moves by a complex Brownian ratchet mechanism in which the translocation along DNA and the binding of nucleotides into RNAP's catalytic center are coupled to a fluctuating internal degree of freedom associated with a protein sub-unit (the F-bridge) of RNAP. More precisely, the model is defined by a set of kinetic equations^ describing the competition for the catalytic site between an incoming nucleotide, the 3'-end of RNA, and the F-bridge which in its bent conformation blocks the active center. An important aspect of the model is the incorporation of the three ``active'' processes describing (i) the ejection of bound nucleotides from the active center through steric clashes with either the F-bridge in its bent conformation or with the 3'-end of RNA; and (ii) the forward translocation induced by bending of the F-bridge pushing against the 3'-end of RNA. The ``active'' processes do not imply a ``power stroke'' mechanism since the energy driving them is purely thermal. Indeed the model displays a route by which the system uses thermal fluctuations to control the rate, processivity and fidelity of transcription already before the irreversible chemical incorporation step. Moreover, the model qualitatively explains many aspects of both bio-chemicalootnotetextBar-Nahum, G., Epshtein, V., Ruckenstein, A.E., Rafikov, R., Mustaev, A., and Nudler, E. A ratchet mechanism of transcription elongation and its

  15. The nature of massive neutrinos and multiple mechanisms in neutrinoless double-beta decay

    NASA Astrophysics Data System (ADS)

    Meroni, Aurora

    2015-11-01

    Determining the nature -Dirac or Majorana- of massive neutrinos is one of the most pressing and challenging problems in the field of neutrino physics. We discuss how one can possibly extract information on the couplings, if any, which might be involved in (ββ)_{0ν}-decay using a multi-isotope approach. We investigate as well the potential of combining data on the half-lives of nuclides with largely different Nuclear Matrix Elements such as 136Xe and of one or more of the four nuclei 76Ge, 82Se, 100Mo and 130Te, for discriminating between different pairs of noninterfering or interfering mechanisms of (ββ)_{0ν}-decay. The case studies do not extend to the evaluation of the theoretical uncertainties of the results, due to the nuclear matrix elements calculations and other causes.

  16. Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones.

    PubMed

    Johansson, Renzo; Jonna, Venkateswara Rao; Kumar, Rohit; Nayeri, Niloofar; Lundin, Daniel; Sjöberg, Britt-Marie; Hofer, Anders; Logan, Derek T

    2016-06-07

    Ribonucleotide reductases (RNRs) reduce ribonucleotides to deoxyribonucleotides. Their overall activity is stimulated by ATP and downregulated by dATP via a genetically mobile ATP cone domain mediating the formation of oligomeric complexes with varying quaternary structures. The crystal structure and solution X-ray scattering data of a novel dATP-induced homotetramer of the Pseudomonas aeruginosa class I RNR reveal the structural bases for its unique properties, namely one ATP cone that binds two dATP molecules and a second one that is non-functional, binding no nucleotides. Mutations in the observed tetramer interface ablate oligomerization and dATP-induced inhibition but not the ability to bind dATP. Sequence analysis shows that the novel type of ATP cone may be widespread in RNRs. The present study supports a scenario in which diverse mechanisms for allosteric activity regulation are gained and lost through acquisition and evolutionary erosion of different types of ATP cone.

  17. Tax deductions, environmental policy, and the double dividend hypothesis

    SciTech Connect

    Parry, I.W.H.; Bento, A.M.

    2000-01-01

    Recent studies find that environmental tax swaps typically exacerbate the costs of the tax system and therefore do not produce a double dividend. The authors extend previous models by incorporating tax-favored consumption goods (e.g., housing, medical care). The efficiency gains from recycling environmental tax revenues are therefore larger because pre-existing income taxes distort both consumption decisions and factor markets. In this setting a revenue-neutral emissions tax (or auctioned permits) produces a double dividend. Moreover, the overall costs of environmental tax swaps are negative, for modest emissions reduction. The efficiency gains from emissions taxes over grandfathered permits are also much larger than previously recognized.

  18. Revisiting "The Loophole of the Improved Secure Quantum Sealed-Bid Auction with Post-Confirmation and Solution"

    NASA Astrophysics Data System (ADS)

    Wang, Qing-Le; Zhang, Wei-Wei; Su, Qi

    2014-09-01

    Recently, Luo et al. make a detailed analysis on the security of quantum sealed-bid auction with post-confirmation protocol (Quantum Information Processing, Volume 11, Issue 6, pp 1359-1369, 2012) and present the corresponding improved strategy for its loophole. Unfortunately, we find their improved version is still not as secure as expected, since it is vulnerable to malicious bidders in collusion with the auctioneer. And there is an unreasonable suspicion in the honesty of the auctioneer for special situation. Then we propose an improved strategy, which can perfectly defeat kinds of attacks.

  19. 31 CFR 356.20 - How does the Treasury determine auction awards?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false How does the Treasury determine auction awards? 356.20 Section 356.20 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT SALE AND ISSUE...

  20. 25 CFR 215.4 - Leases to be sold at public auction.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Leases to be sold at public auction. 215.4 Section 215.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEAD AND ZINC MINING... provided in the regulations in this part, no lead and zinc mining lease under this part of restricted or...

  1. 25 CFR 215.4 - Leases to be sold at public auction.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Leases to be sold at public auction. 215.4 Section 215.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEAD AND ZINC MINING... provided in the regulations in this part, no lead and zinc mining lease under this part of restricted or...

  2. 25 CFR 215.4 - Leases to be sold at public auction.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Leases to be sold at public auction. 215.4 Section 215.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEAD AND ZINC MINING... provided in the regulations in this part, no lead and zinc mining lease under this part of restricted or...

  3. 25 CFR 215.4 - Leases to be sold at public auction.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Leases to be sold at public auction. 215.4 Section 215.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEAD AND ZINC MINING... provided in the regulations in this part, no lead and zinc mining lease under this part of restricted or...

  4. 31 CFR 356.10 - What is the purpose of an auction announcement?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... announcement? 356.10 Section 356.10 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT SALE AND ISSUE OF MARKETABLE...? By issuing an auction announcement, we provide public notice of the sale of bills, notes, and...

  5. 31 CFR 356.10 - What is the purpose of an auction announcement?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... announcement? 356.10 Section 356.10 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT SALE AND ISSUE OF MARKETABLE...? By issuing an auction announcement, we provide public notice of the sale of bills, notes, and...

  6. 77 FR 69933 - Expanding the Economic and Innovation Opportunities of Spectrum Through Incentive Auctions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... Economic and Innovation Opportunities of Spectrum Through Incentive Auctions; Proposed Rule #0;#0;Federal... COMMISSION 47 CFR Parts 1, 27, and 73 Expanding the Economic and Innovation Opportunities of Spectrum Through... of Proposed Rulemaking, ``Expanding the Economic and Innovation Opportunities of Spectrum...

  7. 31 CFR 356.23 - How are the auction results announced?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false How are the auction results announced? 356.23 Section 356.23 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... is available on our Web site at http://www.treasurydirect.gov. (b) The press release will include...

  8. 31 CFR 356.23 - How are the auction results announced?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false How are the auction results announced? 356.23 Section 356.23 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... our Web site at http://www.treasurydirect.gov. (b) The press release will include such information as...

  9. See Art History in a New Light: Have an Art Auction

    ERIC Educational Resources Information Center

    Benter, Doris J.

    2008-01-01

    At Portledge School in Locust Valley, New York, ninth graders in their upper school study art history for one semester. The visual arts department has created a vigorous new syllabus culminating in an hour-long mock art auction. The department selects several art movements (e.g., Post-Impressionism, Cubism, Abstract Expressionism, Social Realism,…

  10. 30 CFR 285.220 - What auction format may MMS use in a lease sale?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What auction format may MMS use in a lease sale? 285.220 Section 285.220 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Issuance of...

  11. 49 CFR Appendix F to Part 599 - Salvage Auction Certification Form

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Salvage Auction Certification Form F Appendix F to Part 599 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY... CONSUMER ASSISTANCE TO RECYCLE AND SAVE ACT PROGRAM Pt. 599, App. F Appendix F to Part 599—Salvage...

  12. 49 CFR Appendix F to Part 599 - Salvage Auction Certification Form

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Salvage Auction Certification Form F Appendix F to Part 599 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY... CONSUMER ASSISTANCE TO RECYCLE AND SAVE ACT PROGRAM Pt. 599, App. F Appendix F to Part 599—Salvage...

  13. 49 CFR Appendix F to Part 599 - Salvage Auction Cerification Form

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Salvage Auction Cerification Form F Appendix F to Part 599 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY... CONSUMER ASSISTANCE TO RECYCLE AND SAVE ACT PROGRAM Pt. 599, App. F Appendix F to Part 599—Salvage...

  14. 40 CFR 97.521 - Recordation of TR NOX Ozone Season allowance allocations and auction results.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Recordation of TR NOX Ozone Season allowance allocations and auction results. 97.521 Section 97.521 Protection of Environment ENVIRONMENTAL... under § 52.38(b)(4) or (5) of this chapter, for the control period in 2014 and 2015. (d) By July 1, 2014...

  15. 40 CFR 97.421 - Recordation of TR NOX Annual allowance allocations and auction results.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Recordation of TR NOX Annual allowance allocations and auction results. 97.421 Section 97.421 Protection of Environment ENVIRONMENTAL PROTECTION... the control period in 2014 and 2015. (d) By July 1, 2014, the Administrator will record in each TR NOX...

  16. 31 CFR 356.33 - Does the Treasury have any discretion in the auction process?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Does the Treasury have any discretion... CIRCULAR, PUBLIC DEBT SERIES NO. 1-93) Miscellaneous Provisions § 356.33 Does the Treasury have any discretion in the auction process? (a) We have the discretion to: (1) Accept, reject, or refuse to...

  17. See Art History in a New Light: Have an Art Auction

    ERIC Educational Resources Information Center

    Benter, Doris J.

    2008-01-01

    At Portledge School in Locust Valley, New York, ninth graders in their upper school study art history for one semester. The visual arts department has created a vigorous new syllabus culminating in an hour-long mock art auction. The department selects several art movements (e.g., Post-Impressionism, Cubism, Abstract Expressionism, Social Realism,…

  18. 75 FR 57947 - Auction of VHF Commercial Television Station Construction Permits Scheduled for February 15, 2011...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ... page at http://www.fcc.gov/cgb/ecfs/ . I. Introduction 1. The Wireless Telecommunications and the Media... TTY: 202-418-0432. The Wireless Telecommunications Bureau requests that a copy of all comments and... INFORMATION CONTACT: Wireless Telecommunications Bureau, Auctions and Spectrum Access Division: For...

  19. Teaching Undergraduate Money and Banking: T-Bill Auctions and Stock Market Models

    ERIC Educational Resources Information Center

    Saros, Daniel E.

    2009-01-01

    The author offers innovative approaches to 3 topics that are typically only briefly mentioned (if at all) in money and banking courses. The first topic is a Treasury bill auction experiment in which students have an opportunity to participate directly. The results from a class of 14 money and banking students are used to explain how an instructor…

  20. Doesticks' Assault on Slavery: Style and Technique in "The Great Auction Sale, at Savannah, Georgia."

    ERIC Educational Resources Information Center

    Piacentino, Edward J.

    1987-01-01

    Analyzes "The Great Auction Sale of Slaves, at Savannah, Georgia" (1859), a popular work by Mortimer Neal Thompson, an American humorist better known by his pseudonym, Q.K. Philander Doesticks, P.B. The book is one of the most readable, credibly authentic accounts of the abuses of slavery. (BJV)

  1. Initial Approaches to Mitigating the Impacts of the AWS-3 Auction (1755-1780 MHz)

    DTIC Science & Technology

    2015-05-13

    and subsequent initial approaches to mitigating the impacts of that auction on Aeronautical Mobile Telemetry (AMT) operations in the 1780-1850 MHz...AWS-3, Aeronautical Mobile Telemetry, LTE-A, Transition Plan, Transmitters, Receivers, Antenna Systems, Bandwidth Efficient Modulation, Spectrum 16

  2. The Use of Reverse Auction Within the U.S. Army

    DTIC Science & Technology

    2016-12-01

    that leverage the power of fluid market conditions through a dynamic pricing environment. This project examines the use of RAs within the Army...of the U.S. Army’s use of reverse auctions (RAs) in regard to contracting. RAs are powerful procurement tools that leverage the power of fluid market ... Market -Based Pricing ..................................................................19  I.  THE PRICING HIERARCHY

  3. 31 CFR 356.20 - How does the Treasury determine auction awards?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... point, for example, 17.13%. (b) Determining the interest rate for new note and bond issues. We set the interest rate at a 1/8 of one percent increment. If a Treasury note or bond auction results in a yield lower than 0.125 percent, the interest rate will be set at 1/8 of one percent, and successful bidders...

  4. 31 CFR 356.11 - How are bids submitted in an auction?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... us to issue the awarded securities in the commercial book-entry system, in TreasuryDirect ®, or in..., our computer time stamp will establish the receipt time. You are bound by your bids after the closing... auctions. (4) Submitters are responsible for bids submitted using computer equipment on their premises...

  5. Ordering competition: the interactional accomplishment of the sale of art and antiques at auction.

    PubMed

    Heath, Christian; Luff, Paul

    2007-03-01

    Auctions provide an institutional solution to a social problem; they enable the legitimate pricing and exchange of goods where those goods are of uncertain value. In turn, auctions raise a number of social and organizational issues that are resolved within the interaction that arise in sales by auction. In this paper, we examine sales of fine art, antiques and objets d'art and explore the ways in which auctioneers mediate competition between buyers and establish a value for goods. In particular, we explore how bids are elicited, co-ordinated and revealed so as to rapidly escalate the price of goods in a transparent manner that enables the legitimate valuation and exchange of goods. In directing attention towards the significance of the social interaction, including talk, visual and material conduct, the paper contributes to the growing corpus of ethnographic studies of markets. It suggests that to understand the operation of markets and their outcomes, and to unpack issues of agency, trust and practice, we need to place the 'interaction order' at the heart of analytic agenda.

  6. Teaching Undergraduate Money and Banking: T-Bill Auctions and Stock Market Models

    ERIC Educational Resources Information Center

    Saros, Daniel E.

    2009-01-01

    The author offers innovative approaches to 3 topics that are typically only briefly mentioned (if at all) in money and banking courses. The first topic is a Treasury bill auction experiment in which students have an opportunity to participate directly. The results from a class of 14 money and banking students are used to explain how an instructor…

  7. 77 FR 73969 - Expanding the Economic and Innovation Opportunities of Spectrum Through Incentive Auctions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Parts 1, 27 and 73 Expanding the Economic and Innovation Opportunities of Spectrum Through... implement an incentive auction of broadcast television spectrum. The NPRM set deadlines for filing...

  8. 49 CFR 580.9 - Odometer record retention for auction companies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Odometer record retention for auction companies. 580.9 Section 580.9 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) ODOMETER DISCLOSURE REQUIREMENTS § 580.9 Odometer record retention fo...

  9. 49 CFR 580.9 - Odometer record retention for auction companies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Odometer record retention for auction companies. 580.9 Section 580.9 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) ODOMETER DISCLOSURE REQUIREMENTS § 580.9 Odometer record retention fo...

  10. 49 CFR 580.9 - Odometer record retention for auction companies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Odometer record retention for auction companies. 580.9 Section 580.9 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) ODOMETER DISCLOSURE REQUIREMENTS § 580.9 Odometer record retention fo...

  11. 49 CFR 580.9 - Odometer record retention for auction companies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Odometer record retention for auction companies. 580.9 Section 580.9 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) ODOMETER DISCLOSURE REQUIREMENTS § 580.9 Odometer record retention fo...

  12. 49 CFR 580.9 - Odometer record retention for auction companies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Odometer record retention for auction companies. 580.9 Section 580.9 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) ODOMETER DISCLOSURE REQUIREMENTS § 580.9 Odometer record retention fo...

  13. Mechanisms of cellular penetration and nuclear localization of an anti-double strand DNA autoantibody.

    PubMed

    Zack, D J; Stempniak, M; Wong, A L; Taylor, C; Weisbart, R H

    1996-09-01

    An anti-dsDNA Ab, mAb 3E10, was identified that bound membranes of fixed human renal tubular cells, penetrated live murine renal tubular cells in vivo, and localized in the cell nucleus. mAb 3E10 binds both dsDNA and an extracellular matrix protein, HP8/HEVIN, expressed in high endothelial venules. Previous studies showed both shared and distinct binding determinants of mAb 3E10 VH for DNA and HP8/HEVIN. To independently assess the requirement of DNA and HP8/HEVIN in cellular penetration, site-directed mutants of mAb 3E10 VH and V kappa were studied for penetrating kidney cell lines. The results showed that residues required for binding DNA, but not HP8/HEVIN, were necessary for Ab penetration, indicating that cellular penetration required the presence of DNA or binding of Ab to a membrane determinant precisely resembling DNA. Ab Fab penetrated cells, indicating that neither the Fc nor multivalent Ab binding is necessary for cellular penetration. Ab synthesized in the cytoplasm as a result of deleting heavy and light chain signal peptides was not translocated to the nucleus, indicating a mechanism distinct from the usual protein nuclear localization signals and suggesting the need for a membrane-mediated pathway or for post-translational modification of the Ab.

  14. Double-Barrier mechanism for chromium immobilization: A quantitative study of crystallization and leachability.

    PubMed

    Liao, Changzhong; Tang, Yuanyuan; Liu, Chengshuai; Shih, Kaimin; Li, Fangbai

    2016-07-05

    Glass-ceramics are well known for the excellent combination properties provided by their components, a glassy matrix and crystalline phases, and have promising applications in the immobilization and detoxification of solid waste containing toxic metals. Glass-ceramic products were successfully synthesized in CaO-MgO-SiO2-Al2O3 -Cr2O3 system. Two key measures--partitioning ratio of Cr in the spinel and Cr leaching ratio--were used to investigate the mechanism of Cr immobilization in the glass-ceramic products. The results of powder X-ray diffraction revealed that both spinel and diopside were major crystalline phases in the products. The value of x in the MgCr(x)Al(2-x)O4 spinel was highly related to the amount of Cr2O3 added to the glass-ceramic system. As Cr2O3 content increased, the proportion of spinel phase increased, while that of glass phase decreased. The partitioning ratio of Cr in spinel phase was about 70% for 2 wt.% Cr2O3, and increased to 90% when loaded with 10 wt.% of Cr2O3. According to the results of the prolonged toxicity characteristic leaching procedure, the Cr leaching ratio decreased with the increase of Cr partitioning ratio into the spinel phase. The findings of this study clearly indicate that glass-ceramic formed by spinel structure and residual glass successfully immobilized Cr.

  15. A prospective, randomized, double-blind, multicenter study comparing remifentanil with fentanyl in mechanically ventilated patients.

    PubMed

    Spies, Claudia; Macguill, Martin; Heymann, Anja; Ganea, Christina; Krahne, Daniel; Assman, Angelika; Kosiek, Heinrich-Rudolf; Scholtz, Kathrin; Wernecke, Klaus-Dieter; Martin, Jörg

    2011-03-01

    To compare the quality of analgesia provided by a remifentanil-based analgesia regime with that provided by a fentanyl-based regime in critically ill patients. This was a registered, prospective, two-center, randomized, triple-blind study involving adult medical and surgical patients requiring mechanical ventilation (MV) for more than 24 h. Patients were randomized to either remifentanil infusion or a fentanyl infusion for a maximum of 30 days. Sedation was provided using propofol (and/or midazolam if required). Primary outcome was the proportion of patients in each group maintaining a target analgesia score at all time points. Secondary outcomes included duration of MV, discharge times, and morbidity. At planned interim analysis (n = 60), 50% of remifentanil patients (n = 28) and 63% of fentanyl patients (n = 32) had maintained target analgesia scores at all time points (p = 0.44). There were no significant differences between the groups with respect to mean duration of ventilation (135 vs. 165 h, p = 0.80), duration of hospital stay, morbidity, or weaning. Interim analysis strongly suggested futility and the trial was stopped. The use of remifentanil-based analgesia in critically ill patients was not superior regarding the achievement and maintenance of sufficient analgesia compared with fentanyl-based analgesia.

  16. Double-stranded DNA translocase activity of transcription factor TFIIH and the mechanism of RNA polymerase II open complex formation.

    PubMed

    Fishburn, James; Tomko, Eric; Galburt, Eric; Hahn, Steven

    2015-03-31

    Formation of the RNA polymerase II (Pol II) open complex (OC) requires DNA unwinding mediated by the transcription factor TFIIH helicase-related subunit XPB/Ssl2. Because XPB/Ssl2 binds DNA downstream from the location of DNA unwinding, it cannot function using a conventional helicase mechanism. Here we show that yeast TFIIH contains an Ssl2-dependent double-stranded DNA translocase activity. Ssl2 tracks along one DNA strand in the 5' → 3' direction, implying it uses the nontemplate promoter strand to reel downstream DNA into the Pol II cleft, creating torsional strain and leading to DNA unwinding. Analysis of the Ssl2 and DNA-dependent ATPase activity of TFIIH suggests that Ssl2 has a processivity of approximately one DNA turn, consistent with the length of DNA unwound during transcription initiation. Our results can explain why maintaining the OC requires continuous ATP hydrolysis and the function of TFIIH in promoter escape. Our results also suggest that XPB/Ssl2 uses this translocase mechanism during DNA repair rather than physically wedging open damaged DNA.

  17. Strong modulation of ectopic focus as a mechanism of repetitive interpolated ventricular bigeminy with heart rate doubling.

    PubMed

    Takayanagi, Kan; Nakahara, Shiro; Toratani, Noritaka; Chida, Ryuji; Kobayashi, Sayuki; Sakai, Yoshihiko; Takeuchi, Akihiro; Ikeda, Noriaki

    2013-10-01

    Repetitive interpolated ventricular bigeminy (RIVB) can introduce a doubling of the ventricular rate. To clarify the mechanism of RIVB, we hypothesized that it was introduced by a strong modulation of the ventricular automatic focus. RIVB, defined as more than 7 bigeminy events, was detected by instantaneous heart rate and bigeminy interval (BI) tachograms in 1450 successive patients with frequent ventricular premature contractions (≥3000 per day). Postextrasystolic interval bigeminy interval curves were plotted to determine the degree of modulation. Mean sinus cycle length bigeminy interval curves were plotted for selection. RIVB was simulated by using a computer-based parasystole model. RIVB was observed in 7 patients (age 60 ± 16 years; 2 men and 5 women) with a heart rate of 58.2 ± 6.5 beats/min during a rest period both during the day and at night. The tachograms disclosed the onset of the RIVB with a doubled ventricular rate to 112.3 ± 8.5 beats/min. On the postextrasystolic interval bigeminy interval curves, compensatory bigeminy and interpolated bigeminy constituted overlapping regression lines with slopes close to 1.00 and RIVB was located in the lower left portion. RIVB lasting for up to 3 hours was quickly detected by mean sinus cycle length bigeminy interval curve. The PQ interval immediately after RIVB was prolonged in comparison with baseline (0.18 ± 0.02 to 0.21 ± 0.02 seconds; P < .001). The simulation was able to reproduce RIVB faithfully at a slow heart rate. Our findings support the hypothesis that RIVB was introduced by strongly modulated ventricular pacemaker accelerated by an intervening normal QRS. © 2013 Heart Rhythm Society. All rights reserved.

  18. [Mechanical properties of polylactic acid/beta-tricalcium phosphate composite scaffold with double channels based on three-dimensional printing technique].

    PubMed

    Lian, Qin; Zhuang, Pei; Li, Changhai; Jin, Zhongmin; Li, Dichen

    2014-03-01

    To improve the poor mechanical strength of porous ceramic scaffold, an integrated method based on three-dimensional (3-D) printing technique is developed to incorporate the controlled double-channel porous structure into the polylactic acid/beta-tricalcium phosphate (PLA/beta-TCP) reinforced composite scaffolds (double-channel composite scaffold) to improve their tissue regeneration capability and the mechanical properties. The designed double-channel structure inside the ceramic scaffold consisted of both primary and secondary micropipes, which parallel but un-connected. The set of primary channels was used for cell ingrowth, while the set of secondary channels was used for the PLA perfusion. Integration technology of 3-D printing technique and gel-casting was firstly used to fabricate the double-channel ceramic scaffolds. PLA/beta-TCP composite scaffolds were obtained by the polymer gravity perfusion process to pour PLA solution into the double-channel ceramic scaffolds through the secondary channel set. Microscope, porosity, and mechanical experiments for the standard samples were used to evaluate the composite properties. The ceramic scaffold with only the primary channel (single-channel scaffold) was also prepared as a control. Morphology observation results showed that there was no PLA inside the primary channels of the double-channel composite scaffolds but a dense interface layer between PLA and beta-TCP obviously formed on the inner wall of the secondary channels by the PLA penetration during the perfusion process. Finite element simulation found that the compressive strength of the double-channel composite scaffold was less than that of the single-channel scaffold; however, mechanical tests found that the maximum compressive strength of the double-channel composite scaffold [(21.25 +/- 1.15) MPa] was higher than that of the single-channel scaffold[ (9.76 +/- 0.64) MPa]. The double-channel composite scaffolds fabricated by 3-D printing technique have

  19. 77 FR 7152 - Mobility Fund Phase I Auction Scheduled for September 27, 2012; Comment Sought on Competitive...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    .... If commenters propose to use different road categories, they should explain their reasoning and... bids, the auction system would use a mathematical optimization procedure to identify the set of...

  20. Analysis, Evaluation and Improvement of Sequential Single-Item Auctions for the Cooperative Real-Time Allocation of Tasks

    DTIC Science & Technology

    2013-03-30

    ICRA Workshop on Search and Pursuit/Evasion in the Physical World: Efficiency, Scalability, and Guarantees in 2010. • Sven Koenig became a member of...that fit the risk preferences of human decision makers in high-stake one- shot decision situations better than current systems. We also describe how to...auction-like algorithm, called Sequential Incremental-Value (SIV) auction, which assigns tasks to robots in multiple rounds. The idea behind SIV

  1. Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms.

    PubMed

    Kostyrko, Kaja; Mermod, Nicolas

    2016-04-07

    DNA double stranded breaks (DSBs) are one of the most deleterious types of DNA lesions. The main pathways responsible for repairing these breaks in eukaryotic cells are homologous recombination (HR) and non-homologous end-joining (NHEJ). However, a third group of still poorly characterized DSB repair pathways, collectively termed microhomology-mediated end-joining (MMEJ), relies on short homologies for the end-joining process. Here, we constructed GFP reporter assays to characterize and distinguish MMEJ variant pathways, namely the simple MMEJ and the DNA synthesis-dependent (SD)-MMEJ mechanisms. Transfection of these assay vectors in Chinese hamster ovary (CHO) cells and characterization of the repaired DNA sequences indicated that while simple MMEJ is able to mediate relatively efficient DSB repair if longer microhomologies are present, the majority of DSBs were repaired using the highly error-prone SD-MMEJ pathway. To validate the involvement of DNA synthesis in the repair process, siRNA knock-down of different genes proposed to play a role in MMEJ were performed, revealing that the knock-down of DNA polymerase θ inhibited DNA end resection and repair through simple MMEJ, thus favoring the other repair pathway. Overall, we conclude that this approach provides a convenient assay to study MMEJ-related DNA repair pathways.

  2. A high security double lock and key mechanism in HUH relaxases controls oriT-processing for plasmid conjugation

    PubMed Central

    Carballeira, José Daniel; González-Pérez, Blanca; Moncalián, Gabriel; de la Cruz, Fernando

    2014-01-01

    Relaxases act as DNA selection sieves in conjugative plasmid transfer. Most plasmid relaxases belong to the HUH endonuclease family. TrwC, the relaxase of plasmid R388, is the prototype of the HUH relaxase family, which also includes TraI of plasmid F. In this article we demonstrate that TrwC processes its target nic-site by means of a highly secure double lock and key mechanism. It is controlled both by TrwC–DNA intermolecular interactions and by intramolecular DNA interactions between several nic nucleotides. The sequence specificity map of the interaction between TrwC and DNA was determined by systematic mutagenesis using degenerate oligonucleotide libraries. The specificity map reveals the minimal nic sequence requirements for R388-based conjugation. Some nic-site sequence variants were still able to form the U-turn shape at the nic-site necessary for TrwC processing, as observed by X-ray crystallography. Moreover, purified TrwC relaxase effectively cleaved ssDNA as well as dsDNA substrates containing these mutant sequences. Since TrwC is able to catalyze DNA integration in a nic-site-containing DNA molecule, characterization of nic-site functionally active sequence variants should improve the search quality of potential target sequences for relaxase-mediated integration in any target genome. PMID:25123661

  3. A high security double lock and key mechanism in HUH relaxases controls oriT-processing for plasmid conjugation.

    PubMed

    Carballeira, José Daniel; González-Pérez, Blanca; Moncalián, Gabriel; de la Cruz, Fernando

    2014-01-01

    Relaxases act as DNA selection sieves in conjugative plasmid transfer. Most plasmid relaxases belong to the HUH endonuclease family. TrwC, the relaxase of plasmid R388, is the prototype of the HUH relaxase family, which also includes TraI of plasmid F. In this article we demonstrate that TrwC processes its target nic-site by means of a highly secure double lock and key mechanism. It is controlled both by TrwC-DNA intermolecular interactions and by intramolecular DNA interactions between several nic nucleotides. The sequence specificity map of the interaction between TrwC and DNA was determined by systematic mutagenesis using degenerate oligonucleotide libraries. The specificity map reveals the minimal nic sequence requirements for R388-based conjugation. Some nic-site sequence variants were still able to form the U-turn shape at the nic-site necessary for TrwC processing, as observed by X-ray crystallography. Moreover, purified TrwC relaxase effectively cleaved ssDNA as well as dsDNA substrates containing these mutant sequences. Since TrwC is able to catalyze DNA integration in a nic-site-containing DNA molecule, characterization of nic-site functionally active sequence variants should improve the search quality of potential target sequences for relaxase-mediated integration in any target genome. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  4. Study of the negative ion extraction mechanism from a double-ion plasma in negative ion sources

    SciTech Connect

    Goto, I.; Nishioka, S.; Hatayama, A.; Miyamoto, K.

    2015-04-08

    We have developed a 2D3V-PIC model of the extraction region, aiming to clarify the basic extraction mechanism of H{sup −} ions from the double-ion plasma in H{sup −} negative ion sources. The result shows the same tendency of the H{sup −} ion density n{sub H{sup −}} as that observed in the experiments, i.e.,n{sub H{sup −}} in the upstream region away from the plasma meniscus (H{sup −} emitting surface) has been reduced by applying the extraction voltage. At the same time, relatively slow temporal oscillation of the electric potential compared with the electron plasma frequency has been observed in the extraction region. Results of the systematic study using a 1D3V-PIC model with the uniform magnetic field confirm the result that the electrostatic oscillation is identified to be lower hybrid wave. The effect of this oscillation on the H{sup −} transport will be studied in the future.

  5. Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms

    PubMed Central

    Kostyrko, Kaja; Mermod, Nicolas

    2016-01-01

    DNA double stranded breaks (DSBs) are one of the most deleterious types of DNA lesions. The main pathways responsible for repairing these breaks in eukaryotic cells are homologous recombination (HR) and non-homologous end-joining (NHEJ). However, a third group of still poorly characterized DSB repair pathways, collectively termed microhomology-mediated end-joining (MMEJ), relies on short homologies for the end-joining process. Here, we constructed GFP reporter assays to characterize and distinguish MMEJ variant pathways, namely the simple MMEJ and the DNA synthesis-dependent (SD)-MMEJ mechanisms. Transfection of these assay vectors in Chinese hamster ovary (CHO) cells and characterization of the repaired DNA sequences indicated that while simple MMEJ is able to mediate relatively efficient DSB repair if longer microhomologies are present, the majority of DSBs were repaired using the highly error-prone SD-MMEJ pathway. To validate the involvement of DNA synthesis in the repair process, siRNA knock-down of different genes proposed to play a role in MMEJ were performed, revealing that the knock-down of DNA polymerase θ inhibited DNA end resection and repair through simple MMEJ, thus favoring the other repair pathway. Overall, we conclude that this approach provides a convenient assay to study MMEJ-related DNA repair pathways. PMID:26657630

  6. Stimulating somatosensory psychophysics: a double-blind, sham-controlled study of the neurobiological mechanisms of tDCS

    PubMed Central

    Hanley, Claire J.; Tommerdahl, Mark; McGonigle, David J.

    2015-01-01

    The neuromodulation technique transcranial direct current stimulation (tDCS) is thought to produce its effects on behavior by altering cortical excitability. Although the mechanisms underlying the observed effects are thought to rely on the balance of excitatory and inhibitory neurotransmission, the physiological principles of the technique are not completely understood. In this study, we examine the influence of tDCS on vibrotactile adaptation, using a simple amplitude discrimination paradigm that has been shown to exhibit modifications in performance due to changes in inhibitory neurotransmission. Double-blind tDCS (Anodal/Sham) of 1 mA was delivered for 600 s to electrodes positioned in a somatosensory/contralateral orbit montage. Stimulation was applied as part of a pre/post design, between blocks of the behavioral tasks. In accordance with previous work, results obtained before the application of tDCS indicated that amplitude discrimination thresholds were significantly worsened during adaptation trials, compared to those achieved at baseline. However, tDCS failed to modify amplitude discrimination performance. Using a Bayesian approach, this finding was revealed to constitute substantial evidence for the null hypothesis. The failure of DC stimulation to alter vibrotactile adaptation thresholds is discussed in the context of several factors that may have confounded the induction of changes in cortical plasticity. PMID:26500499

  7. Studying dielectric mechanism and magnetization of double perovskite Gd{sub 2}NiMnO{sub 6} ceramic

    SciTech Connect

    Mohapatra, S. R.; Sahu, B. Singh, A. K.; Kaushik, S. D.

    2016-05-23

    In the present work, the structure, dielectric and magnetic properties of Gd{sub 2}NiMnO{sub 6} double perovskite have been studied. X-Ray diffraction study reveals the phase pure formation of the material that crystallizes into monoclinic phase (space group ’P2{sub 1}/n’). Surface morphology depicts heterogeneous grain distribution with average grain size of ~1 µm. Temperature dependent (50 – 330 K) dielectric measurements at different frequencies (0.5 - 50 kHz) relate to Maxwell-Wagner interfacial polarization model. Giant dielectric constant at 1 kHz for 300 K (ε’ ~1900) is noticed as compared to that of 50 K (ε’ ~10) coupled with a peak shift in tan loss towards higher temperature with frequency. The activation energy (0.24 eV) obtained using Arrhenius relation for thermally activated relaxor behavior of the material signifies an electron hopping mechanism between Ni{sup 2+} and Mn{sup 4+} cations. Lastly, M-H study shows ‘S’ shape hysteresis loop at 50 K with remnant magnetization (M{sub r}) of 0.72 µ{sub B}/f.u. along with a linear plot for 300 K which reveals paramagnetic nature of the material.

  8. I-SceI endonuclease, a new tool for studying DNA double-strand break repair mechanisms in Drosophila.

    PubMed Central

    Bellaiche, Y; Mogila, V; Perrimon, N

    1999-01-01

    As a step toward the development of a homologous recombination system in Drosophila, we have developed a methodology to target double-strand breaks (DSBs) to a specific position in the Drosophila genome. This method uses the mitochondrial endonuclease I-SceI that recognizes and cuts an 18-bp restriction site. We find that >6% of the progeny derived from males that carry a marker gene bordered by two I-SceI sites and that express I-SceI in their germ line lose the marker gene. Southern blot analysis and sequencing of the regions surrounding the I-SceI sites revealed that in the majority of the cases, the introduction of DSBs at the I-SceI sites resulted in the complete deletion of the marker gene; the other events were associated with partial deletion of the marker gene. We discuss a number of applications for this novel technique, in particular its use to study DSB repair mechanisms. PMID:10388822

  9. In vitro MRI of biodegradable hybrid (iron oxide/polycaprolactone) magnetic nanoparticles prepared via modified double emulsion evaporation mechanism.

    PubMed

    Ahmed, Naveed; Ahmad, Nasir M; Fessi, Hatem; Elaissari, Abdelhamid

    2015-06-01

    Hybrid magnetic particles are being applied in biomedical field for various aims. One of such aim is use of magnetic particles for diagnostic purposes especially in imaging mechanisms. In vitro magnetic resonance imaging of biodegradable hybrid (iron oxide/polycaprolactone) magnetic nanoparticles is carried out. Hybrid magnetic nanoparticles were prepared by encapsulation of iron oxide nanoparticles (IONPs) in polycaprolactone (PCL) via modified double emulsion evaporation technique. Both the IONPs and hybrid nanoparticles were characterized for their sizes, zeta potential, microscopic, thermogravimetric, and magnetism. Prepared particles were investigated for T1 and T2 weighted enhancement of contrast in vitro in water. A comparison of the prepared particles was done with commercially available Gadolinium for the contrast efficiency in MRI. Results showed the prepared particles exhibited nanosize range, good morphology and superparamagnetic character. The enhancement in the MRI contrast of the prepared particles was observed and found to depend on type of the prepared particles. Comparison of the MRI contrast of the prepared particles with the commercial Gadolinium suggests their usefulness as T2 contrast agent. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Scaling of volume to surface ratio and doubling time in growing unicellular organisms: Do cells appear quantum-mechanical systems?

    SciTech Connect

    Atanasov, Atanas Todorov

    2014-10-06

    The scaling of physical and biological characteristics of the living organisms is a basic method for searching of new biophysical laws. In series of previous studies the author showed that in Poikilotherms, Mammals and Aves, the volume to surface ratio V×S{sup −1} (m) of organisms is proportional to their generation time T{sub gt}(s) via growth rate v (m s{sup −1}): V×S{sup −1} = v{sub gr}×T{sup r}. The power and the correlation coefficients are near to 1.0. Aim of this study is: i) to prove with experimental data the validity of the above equation for Unicellular organisms and ii) to show that perhaps, the cells are quantum-mechanical systems. The data for body mass M (kg), density ρ (kg/m{sup 3}), minimum and maximum doubling time T{sub dt} (s) for 50 unicellular organisms are assembled from scientific sources, and the computer program ‘Statistics’ is used for calculations. In result i) the analytical relationship from type: V×S{sup −1} = 4.46⋅10{sup −11}×T{sub dt} was found, where v{sub gr} = 4.46×10{sup −11} m/s and ii) it is shown that the products between cell mass M, cell length expressed by V/S ratio and growth rate v{sub gr} satisfied the Heisenberg uncertainty principle i.e. the inequalities V/S×M×v{sub gr}>h/2π and T{sub dt}×M×v{sub gr}{sup 2}>h/2π are valid, where h= 6.626×10{sup −34} J⋅s is the Planck constant. This rise the question: do cells appear quantum-mechanical systems?.

  11. Scaling of volume to surface ratio and doubling time in growing unicellular organisms: Do cells appear quantum-mechanical systems?

    NASA Astrophysics Data System (ADS)

    Atanasov, Atanas Todorov

    2014-10-01

    The scaling of physical and biological characteristics of the living organisms is a basic method for searching of new biophysical laws. In series of previous studies the author showed that in Poikilotherms, Mammals and Aves, the volume to surface ratio V×S-1 (m) of organisms is proportional to their generation time Tgt(s) via growth rate v (m s-1): V×S-1 = vgr×Tr. The power and the correlation coefficients are near to 1.0. Aim of this study is: i) to prove with experimental data the validity of the above equation for Unicellular organisms and ii) to show that perhaps, the cells are quantum-mechanical systems. The data for body mass M (kg), density ρ (kg/m3), minimum and maximum doubling time Tdt (s) for 50 unicellular organisms are assembled from scientific sources, and the computer program `Statistics' is used for calculations. In result i) the analytical relationship from type: V×S-1 = 4.46ṡ10-11×Tdt was found, where vgr = 4.46×10-11 m/s and ii) it is shown that the products between cell mass M, cell length expressed by V/S ratio and growth rate vgr satisfied the Heisenberg uncertainty principle i.e. the inequalities V/S×M×vgr>h/2π and Tdt×M×vgr2>h/2π are valid, where h= 6.626×10-34 Jṡs is the Planck constant. This rise the question: do cells appear quantum-mechanical systems?

  12. A Structure-Activity Analysis for Probing the Mechanism of Processive Double-Stranded DNA Digestion by λ Exonuclease Trimers.

    PubMed

    Pan, Xinlei; Smith, Christopher E; Zhang, Jinjin; McCabe, Kimberly A; Fu, Jun; Bell, Charles E

    2015-10-06

    λ exonuclease (λexo) is an ATP-independent 5'-to-3' exonuclease that binds to double-stranded DNA (dsDNA) ends and processively digests the 5'-strand into mononucleotides. The crystal structure of λexo revealed that the enzyme forms a ring-shaped homotrimer with a central funnel-shaped channel for tracking along the DNA. On the basis of this structure, it was proposed that dsDNA enters the open end of the channel, the 5'-strand is digested at one of the three active sites, and the 3'-strand passes through the narrow end of the channel to emerge out the back. This model was largely confirmed by the structure of the λexo-DNA complex, which further revealed that the enzyme unwinds the DNA by 2 bp prior to cleavage, to thread the 5'-end of the DNA into the active site. On the basis of this structure, an "electrostatic ratchet" model was proposed, in which the enzyme uses a hydrophobic wedge to insert into the base pairs to unwind the DNA, a two-metal mechanism for nucleotide hydrolysis, a positively charged pocket to bind to the terminal 5'-phosphate generated after each round of cleavage, and an arginine residue (Arg-45) to bind to the minor groove of the downstream end of the DNA. To test this model, in this study we have determined the effects of 11 structure-based mutations in λexo on DNA binding and exonuclease activities in vitro, and on DNA recombination in vivo. The results are largely consistent with the model for the mechanism that was proposed on the basis of the structure and provide new insights into the roles of particular residues of the protein in promoting the reaction. In particular, a key role for Arg-45 in DNA binding is revealed.

  13. Double Mantle Plume Upwelling—A Possible Formation Mechanism of Beta Plateau and Devana Chasma,Venus

    NASA Astrophysics Data System (ADS)

    Ding, N.

    2009-12-01

    Ning Ding,Zuoxun Zeng,China University of Geosciences,Wuhan,430074,China NingDing.eagle@gmail.com Introduction:Venus represents a‘one plate planet’[1],and the uplift,fractures and volcanism in Beta Regio on Venus are considered to be formed by lithosphere uplift driven by a hot plume[2]. Based on the double peaking saddle landform,we suggest the tectonic pattern of double mantle plume upwelling to interpret the formation mechanism of Beta Plateau and Devana Chasma.We take a physical modeling to validate this possibility. Model:There is no ductile shear in Venus[3],so we use quartz sands to simulate the crust of Venus.We use two wood stickes 1.5cm in diameter rising from the rubber canvas slowly and straight till about half of the model,then falling down slowly and straight.The base is a hard rubber plate,in the center of which,there are two holes 3cm in diameter,and the distance between them is 5cm.The holes are covered by rubber canvas.We use the quartz sands in colours of white, red and black with particle size of 70 mess as the model materials. Result:Fig.1:At the beginning of the wood stickes upwelling,only fine radial cracks are formed above the upwelling from central to outside.With the upwelling continue,surface energy of the fine radial cracks increase and make the cracks unstable,finally,the fine radial cracks connect each other and form a fracture zone.And then the two mantle plume downwelling,the fracture zone is developed to form a chasma at the end. Fig.2:The four profiles all form reverse faults outside and normal faults inside.But the difference is the faults in the middle of the chasma goes deeper than others.It is the pattern of Beta Plateau where the tectonic rising is cut by Devana Chasma zone in the topographic features. Fig.3:From the tow fig., we can see two points similar:a.the elevation is high and distribution area is large around the area of two upwelling and it is high around the area of chasma,but the distribution area is small

  14. Shear-tensile crack as a tool for reliable estimates of the non-double-couple mechanism: West Bohemia-Vogtland earthquake 1997 swarm

    NASA Astrophysics Data System (ADS)

    Šílený, Jan; Horálek, Josef

    2016-10-01

    Shear-tensile crack is a model for an earthquake mechanism that is more constrained than the moment tensor but that can still describe a non-shear focus. As such, the shear-tensile crack model is more robust than the moment tensor model and yields more reliable estimates for the earthquake mechanism. Such an advantage verifies the credibility of the non-double-couple component found for some events of the 1997 West Bohemia-Vogtland earthquake swarm. As expected, in several cases, a significantly resolved non-double-couple component was obtained where the moment tensor approach failed. Additionally, for non-shear sources, the shear-tensile crack model offers optimization of the Poisson number within the focus, concurrently with retrieval of the mechanism. However, results obtained for the joint inversion of the 1997 swarm indicate that resolution is low. A series of synthetic experiments indicated that limited observations during 1997 were not the cause. Rather, hypothetical experiments of both very good and extremely poor network configurations similarly yielded a low resolution for the Poisson number. Applying this method to data for recent swarms is irrelevant because the small non-double-couple components detected within the inversion are spurious and, thus, the events are pure double-couple phenomena.

  15. Analytical approaches for clarification of DNA-double decker phthalocyanine binding mechanism: As an alternative anticancer chemotherapeutic

    NASA Astrophysics Data System (ADS)

    Bağda, Esra; Yabaş, Ebru; Bağda, Efkan

    2017-02-01

    In the present study a novel water soluble double-decker phthalocyanine was synthesized and calf thymus DNA interaction of the synthesized double-decker phthalocyanine was investigated. 5-(3-pyridyl)-1,3,4-oxadiazole substituted phthalonitrile 1 was prepared by a nucleophilic displacement reaction of 4-nitrophthalonitrile with 5-(3-pyridyl)-1,3,4-oxadiazole-2-thiol. Lutetium(III) double-decker phthalocyanine 2 was prepared by cyclotetramerization of compound 1. Water soluble lutetium(III) double-decker phthalocyanine 3 was prepared with quaternarization of compound 2. The synthesized double-decker phthalocyanine and calf thymus DNA interaction was investigated with UV-vis titrimetric methods, gel electrophoresis, and viscosity measurements. The fluorometric ethidium bromide replacement assay was conducted to clarify the binding mode of water soluble double-decker phthalocyanine. The thermodynamic parameters for interaction, K, ΔG0, ΔH0 and ΔS0 were calculated between the temperature ranges of 25 °C-75 °C. To the best of our knowledge, this is the first study about a double-decker phthalocyanine and DNA interaction.

  16. Analytical approaches for clarification of DNA-double decker phthalocyanine binding mechanism: As an alternative anticancer chemotherapeutic.

    PubMed

    Bağda, Esra; Yabaş, Ebru; Bağda, Efkan

    2017-02-05

    In the present study a novel water soluble double-decker phthalocyanine was synthesized and calf thymus DNA interaction of the synthesized double-decker phthalocyanine was investigated. 5-(3-pyridyl)-1,3,4-oxadiazole substituted phthalonitrile 1 was prepared by a nucleophilic displacement reaction of 4-nitrophthalonitrile with 5-(3-pyridyl)-1,3,4-oxadiazole-2-thiol. Lutetium(III) double-decker phthalocyanine 2 was prepared by cyclotetramerization of compound 1. Water soluble lutetium(III) double-decker phthalocyanine 3 was prepared with quaternarization of compound 2. The synthesized double-decker phthalocyanine and calf thymus DNA interaction was investigated with UV-vis titrimetric methods, gel electrophoresis, and viscosity measurements. The fluorometric ethidium bromide replacement assay was conducted to clarify the binding mode of water soluble double-decker phthalocyanine. The thermodynamic parameters for interaction, K, ΔG(0), ΔH(0) and ΔS(0) were calculated between the temperature ranges of 25°C-75°C. To the best of our knowledge, this is the first study about a double-decker phthalocyanine and DNA interaction.

  17. Double screening

    SciTech Connect

    Gratia, Pierre; Hu, Wayne; Joyce, Austin; Ribeiro, Raquel H.

    2016-06-15

    Attempts to modify gravity in the infrared typically require a screening mechanism to ensure consistency with local tests of gravity. These screening mechanisms fit into three broad classes; we investigate theories which are capable of exhibiting more than one type of screening. Specifically, we focus on a simple model which exhibits both Vainshtein and kinetic screening. We point out that due to the two characteristic length scales in the problem, the type of screening that dominates depends on the mass of the sourcing object, allowing for different phenomenology at different scales. We consider embedding this double screening phenomenology in a broader cosmological scenario and show that the simplest examples that exhibit double screening are radiatively stable.

  18. Encouraging information sharing to boost the name-your-own-price auction

    NASA Astrophysics Data System (ADS)

    Chen, Yahong; Li, Jinlin; Huang, He; Ran, Lun; Hu, Yusheng

    2017-08-01

    During a name-your-own-price (NYOP) auction, buyers can learn a lot of knowledge from their socially connected peers. Such social learning process makes them become more active to attend the auction and also helps them make decisions on what price to submit. Combining an information diffusion model and a belief decision model, we explore three effects of bidders' information sharing on the buyers' behaviors and the seller profit. The results indicate that information sharing significantly increases the NYOP popularity and the seller profit. When enlarging the quality or quantity of information sharing, or increasing the spreading efficiency of the network topology, the number of attenders and the seller profit are increased significantly. However, the spread of information may make bidders be more likely to bid higher and consequently lose surplus. In addition, the different but interdependent influence of the successful information and failure information are discussed in this work.

  19. Equilibrium Strategy and Population-Size Effects in Lowest Unique Bid Auctions

    NASA Astrophysics Data System (ADS)

    Pigolotti, Simone; Bernhardsson, Sebastian; Juul, Jeppe; Galster, Gorm; Vivo, Pierpaolo

    2012-02-01

    In lowest unique bid auctions, N players bid for an item. The winner is whoever places the lowest bid, provided that it is also unique. We use a grand canonical approach to derive an analytical expression for the equilibrium distribution of strategies. We then study the properties of the solution as a function of the mean number of players, and compare them with a large data set of internet auctions. The theory agrees with the data with striking accuracy for small population-size N, while for larger N a qualitatively different distribution is observed. We interpret this result as the emergence of two different regimes, one in which adaptation is feasible and one in which it is not. Our results question the actual possibility of a large population to adapt and find the optimal strategy when participating in a collective game.

  20. Biased Random-Key Genetic Algorithms for the Winner Determination Problem in Combinatorial Auctions.

    PubMed

    de Andrade, Carlos Eduardo; Toso, Rodrigo Franco; Resende, Mauricio G C; Miyazawa, Flávio Keidi

    2015-01-01

    In this paper we address the problem of picking a subset of bids in a general combinatorial auction so as to maximize the overall profit using the first-price model. This winner determination problem assumes that a single bidding round is held to determine both the winners and prices to be paid. We introduce six variants of biased random-key genetic algorithms for this problem. Three of them use a novel initialization technique that makes use of solutions of intermediate linear programming relaxations of an exact mixed integer linear programming model as initial chromosomes of the population. An experimental evaluation compares the effectiveness of the proposed algorithms with the standard mixed linear integer programming formulation, a specialized exact algorithm, and the best-performing heuristics proposed for this problem. The proposed algorithms are competitive and offer strong results, mainly for large-scale auctions.

  1. A Supplier Bidding Strategy Through Q-Learning Algorithm in Electricity Auction Markets

    NASA Astrophysics Data System (ADS)

    Xiong, Gaofeng; Hashiyama, Tomonori; Okuma, Shigeru

    One of the most important issues for power suppliers in the deregulated electric industry is how to bid into the electricity auction market to satisfy their profit-maximizing goals. Based on the Q-Learning algorithm, this paper presents a novel supplier bidding strategy to maximize supplier’s profit in the long run. In this approach, the supplier bidding strategy is viewed as a kind of stochastic optimal control problem and each supplier can learn from experience. A competitive day-ahead electricity auction market with hourly bids is assumed here, where no supplier possesses the market power. The dynamics and the incomplete information of the market are considered. The impacts of suppliers’ strategic bidding on the market price are analyzed under uniform pricing rule and discriminatory pricing rule. Agent-based simulations are presented. The simulation results show the feasibility of the proposed bidding strategy.

  2. A Q-Learning-Based Supplier Bidding Strategy in Electricity Auction Market

    NASA Astrophysics Data System (ADS)

    Xiong, Gaofeng; Hashiyama, Tomonori; Okuma, Shigeru

    One of the most important issues for power suppliers in the deregulated electric industry is how to bid into the electricity auction market to satisfy their profit-maximizing goals. Based on the Q-Learning algorithm, this paper presents a novel supplier bidding strategy to maximize supplier’s profit in the long run. In this approach, the supplier bidding strategy is viewed as one kind of stochastic optimal control problem and each supplier can learn from experience. A competitive day-ahead electricity auction market with hourly bids is assumed here, where no supplier possesses the market power and all suppliers winning the market are paid based on their own bid prices. The dynamics and the incomplete information of the market are considered. The impact of suppliers’ strategic bidding on the market price is analyzed. Agent-based simulations are presented. The simulation results show the feasibility of the proposed bidding strategy.

  3. Collective induction without cooperation? Learning and knowledge transfer in cooperative groups and competitive auctions.

    PubMed

    Maciejovsky, Boris; Budescu, David V

    2007-05-01

    There is strong evidence that groups perform better than individuals do on intellective tasks with demonstrably correct solutions. Typically, these studies assume that group members share common goals. The authors extend this line of research by replacing standard face-to-face group interactions with competitive auctions, allowing for conflicting individual incentives. In a series of studies involving the well-known Wason selection task, they demonstrate that competitive auctions induce learning effects equally impressive as those of standard group interactions, and they uncover specific and general knowledge transfers from these institutions to new reasoning problems. The authors identify payoff feedback and information pooling as the driving factors underlying these findings, and they explain these factors within the theoretical framework of collective induction.

  4. The transition mechanism from a symmetric single period discharge to a period-doubling discharge in atmospheric helium dielectric-barrier discharge

    SciTech Connect

    Zhang, Dingzong; Wang, Yanhui; Wang, Dezhen

    2013-06-15

    Period-doubling and chaos phenomenon have been frequently observed in atmospheric-pressure dielectric-barrier discharges. However, how a normal single period discharge bifurcates into period-doubling state is still unclear. In this paper, by changing the driving frequency, we study numerically the transition mechanisms from a normal single period discharge to a period-doubling state using a one-dimensional self-consistent fluid model. The results show that before a discharge bifurcates into a period-doubling state, it first deviates from its normal operation and transforms into an asymmetric single period discharge mode. Then the weaker discharge in this asymmetric discharge will be enhanced gradually with increasing of the frequency until it makes the subsequent discharge weaken and results in the discharge entering a period-doubling state. In the whole transition process, the spatial distribution of the charged particle density and the electric field plays a definitive role. The conclusions are further confirmed by changing the gap width and the amplitude of the applied voltage.

  5. Research at the auction block: Problems for the fair benefits approach to international research.

    PubMed

    London, Alex John; Zollman, Kevin J S

    2010-01-01

    The "fair benefits" approach to international research is designed to produce results that all can agree are fair without taking a stand on divisive questions of justice. But its appealing veneer of collaboration masks ambiguities at both a conceptual and an operational level. An attempt to put it into practice would look a lot like an auction, leaving little reason to think the outcomes will satisfy even minimal conditions of fairness.

  6. 31 CFR 356.20 - How does the Treasury determine auction awards?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... hundredth of a whole percentage point, for example, 17.13%. (b) Determining the interest rate for new note and bond issues. We set the interest rate at a 1/8 of one percent increment. If a Treasury note or bond auction results in a yield lower than 0.125 percent, the interest rate will be set at 1/8 of one...

  7. 31 CFR 356.20 - How does the Treasury determine auction awards?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... hundredth of a whole percentage point, for example, 17.13%. (b) Determining the interest rate for new note and bond issues. We set the interest rate at a 1/8 of one percent increment. If a Treasury note or bond auction results in a yield lower than 0.125 percent, the interest rate will be set at 1/8 of one...

  8. 31 CFR 356.20 - How does the Treasury determine auction awards?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... hundredth of a whole percentage point, for example, 17.13%. (b) Determining the interest rate for new note and bond issues. We set the interest rate at a 1/8 of one percent increment. If a Treasury note or bond auction results in a yield lower than 0.125 percent, the interest rate will be set at 1/8 of one...

  9. The mechanism of adenosine to inosine conversion by the double-stranded RNA unwinding/modifying activity: A high-performance liquid chromatography-mass spectrometry analysis

    SciTech Connect

    Polson, A.G.; Crain, P.F.; Pomerantz, S.C.; McCloskey, J.A.; Bass, B.L. )

    1991-12-10

    The authors have used directly combined high-performance liquid chromatography-mass spectrometry (LC/MS) to examine the mechanism of the reaction catalyzed by the double-stranded RNA unwinding/modifying activity. A double-stranded RNA substrate in which all adenosines were uniformly labeled with {sup 13}C was synthesized. An LC/MS analysis of the nucleoside products from the modified, labeled substrate confirmed that adenosine is modified to inosine during the unwinding/modifying reaction. Most importantly, they found that no carbons are exchanged during the reaction. By including H{sub 2} {sup 18}O in the reaction, they showed that water serves efficiently as the oxygen donor in vitro. These results are consistent with a hydrolytic deamination mechanism and rule out a base replacement mechanism. Although the double-stranded RNA unwinding/modifying activity appears to utilize a catalytic mechanism similar to that of adenosine deaminase, coformycin, a transition-state analogue, will not inhibit the unwinding/modifying activity.

  10. Mechanical characteristics of a double-fed machine in asynchronous mode and prospects of its application in the electric drive of mining machines

    NASA Astrophysics Data System (ADS)

    Ostrovlyanchik, V. Yu; Popolzin, I. Yu; Kubarev, V. A.; Marshev, D. A.

    2017-09-01

    The concept of a double-fed machine as an asynchronous motor with a phase rotor and a source of additional voltage is defined. Based on the analysis of a circuit replacing the double-fed machine, an expression is derived relating the moment, slip, amplitude and phase of additional voltage across the rotor. The conditions maximizing the moment with respect to amplitude and phase of additional voltage in the rotor circuit are also obtained, the phase surface of function of machine electromagnetic moment is constructed. The analysis of basic equation of electric drive motion in relation to electric drive of mine hoisting installations and the conclusion about the necessity of work in all four quadrants of coordinate plane “moment-slip” are made. Family of mechanical characteristics is constructed for a double-fed machine and its achievable speed control range in asynchronous mode is determined. Based on the type of mechanical characteristics and the calculated range of speed control, the conclusion is made about the suitability of using a dual-fed asynchronous machine for driving mine mechanisms with a small required speed control range and the need for organizing a combined operating mode for driving mine hoisting installations and other mechanisms with a large speed control range.

  11. The answer to concerted versus step-wise controversy for the double proton transfer mechanism of 7-azaindole dimer in solution

    PubMed Central

    Takeuchi, Satoshi; Tahara, Tahei

    2007-01-01

    The dynamics and mechanism of the double proton transfer reaction of the 7-azaindole dimer was investigated in solution by excitation wavelength dependence in steady-state and femtosecond time-resolved fluorescence spectroscopy. Femtosecond measurements in the UV region revealed that the dynamics of the dimer fluorescence exhibits remarkable change as the excitation wavelength was scanned from 280 to 313 nm. The fluorescence showed a biexponential decay (0.2 and 1.1 ps) with 280-nm excitation, whereas it exhibited a single exponential decay (1.1 ps) with 313-nm excitation (the red-edge of the dimer absorption). This observation clearly indicates that the 0.2-ps component is irrelevant to the proton transfer. In the visible region, we found that the tautomer fluorescence rises in accordance with the decay of the dimer fluorescence with a common time constant of 1.1 ps. This finding unambiguously denies the appearance of any intermediate species in between the dimer and tautomer excited states, indicating that the double proton transfer reaction is essentially a single-step process. We conclude that the double proton transfer of the 7-azaindole dimer in solution proceeds in the concerted manner from the lowest excited state with the 1.1-ps time constant. On the basis of the experimental data obtained, we discuss the long-lasting concerted versus step-wise controversy for the double proton transfer mechanism in solution. PMID:17374721

  12. The answer to concerted versus step-wise controversy for the double proton transfer mechanism of 7-azaindole dimer in solution.

    PubMed

    Takeuchi, Satoshi; Tahara, Tahei

    2007-03-27

    The dynamics and mechanism of the double proton transfer reaction of the 7-azaindole dimer was investigated in solution by excitation wavelength dependence in steady-state and femtosecond time-resolved fluorescence spectroscopy. Femtosecond measurements in the UV region revealed that the dynamics of the dimer fluorescence exhibits remarkable change as the excitation wavelength was scanned from 280 to 313 nm. The fluorescence showed a biexponential decay (0.2 and 1.1 ps) with 280-nm excitation, whereas it exhibited a single exponential decay (1.1 ps) with 313-nm excitation (the red-edge of the dimer absorption). This observation clearly indicates that the 0.2-ps component is irrelevant to the proton transfer. In the visible region, we found that the tautomer fluorescence rises in accordance with the decay of the dimer fluorescence with a common time constant of 1.1 ps. This finding unambiguously denies the appearance of any intermediate species in between the dimer and tautomer excited states, indicating that the double proton transfer reaction is essentially a single-step process. We conclude that the double proton transfer of the 7-azaindole dimer in solution proceeds in the concerted manner from the lowest excited state with the 1.1-ps time constant. On the basis of the experimental data obtained, we discuss the long-lasting concerted versus step-wise controversy for the double proton transfer mechanism in solution.

  13. Improving the secrecy rate by turning foes to allies: An auction scheme

    NASA Astrophysics Data System (ADS)

    Ma, Ya-Yan; Wang, Bao-Yun

    2015-09-01

    Security against eavesdroppers is a critical issue in cognitive radio networks (CRNs). In this paper, a scenario consisting of one primary pair and multiple secondary pairs is considered. The secondary transmitters (STs) work in half-duplex mode and they are potential eavesdroppers on the primary transmission unless they are allowed to simultaneously transmit with the primary transmitter (PT). A modified second-price sealed-bid auction scheme is employed to model the interaction between the PT and STs. With the proposed auction scheme, the hostile relationship between the PT and STs is transformed into a cooperative relationship. An iterative algorithm based on the max-min criteria is proposed to find the optimal bidding power of the STs for an access chance in the presence of multiple eavesdroppers. Numerical results show that the proposed auction scheme not only improves the PT’s security but also increases the access opportunities of the STs. Project supported by the National Natural Science Foundation of China (Grant Nos. 61271232 and 61372126) and the University Postgraduate Research and Innovation Project in Jiangsu Province, China (Grant No. CXZZ12-0472).

  14. Quantum sealed-bid auction using a modified scheme for multiparty circular quantum key agreement

    NASA Astrophysics Data System (ADS)

    Sharma, Rishi Dutt; Thapliyal, Kishore; Pathak, Anirban

    2017-07-01

    A feasible, secure and collusion attack-free quantum sealed-bid auction protocol is proposed using a modified scheme for multiparty circular quantum key agreement. In the proposed protocol, the set of all ( n) bidders is grouped into l subsets (sub-circles) in such a way that only the initiator (who prepares the quantum state to be distributed for a particular round of communication and acts as the receiver in that round) is a member of all the subsets (sub-circles) prepared for a particular round, while any other bidder is part of only a single subset. All n bidders and auctioneer initiate one round of communication, and each of them prepares l copies of a ( r-1) -partite entangled state (one for each sub-circle), where r=n/l+1. The efficiency and security of the proposed protocol are critically analyzed. It is shown that the proposed protocol is free from the collusion attacks that are possible on the existing schemes of quantum sealed-bid auction. Further, it is observed that the security against collusion attack increases with the increase in l, but that reduces the complexity (number of entangled qubits in each entangled state) of the entangled states to be used and that makes the scheme scalable and implementable with the available technologies. The additional security and scalability are shown to arise due to the use of a circular structure in place of a complete-graph or tree-type structure used earlier.

  15. Probing the Mechanism of the Double C—H (De)Activation Route of a Ru-Based Olefin Metathesis Catalyst

    NASA Astrophysics Data System (ADS)

    Poater, Albert; Cavallo, Luigi

    A theoretical study of a double C—H activation mechanism that deactivates a family of second generation Ru-based catalysts is presented. DFT calculations are used to rationalize the complex mechanistic pathway from the starting precatalyst to the experimentally characterized decomposition products. In particular, we show that all the intermediates proposed by Grubbs and coworkers are indeed possible intermediates in the deactivation pathway, although the sequence of steps is somewhat different

  16. Multisoliton solutions in terms of double Wronskian determinant for a generalized variable-coefficient nonlinear Schroedinger equation from plasma physics, arterial mechanics, fluid dynamics and optical communications

    SciTech Connect

    Lue Xing Zhu Hongwu; Yao Zhenzhi; Meng Xianghua; Zhang Cheng; Zhang Chunyi; Tian Bo

    2008-08-15

    In this paper, the multisoliton solutions in terms of double Wronskian determinant are presented for a generalized variable-coefficient nonlinear Schroedinger equation, which appears in space and laboratory plasmas, arterial mechanics, fluid dynamics, optical communications and so on. By means of the particularly nice properties of Wronskian determinant, the solutions are testified through direct substitution into the bilinear equations. Furthermore, it can be proved that the bilinear Baecklund transformation transforms between (N - 1)- and N-soliton solutions.

  17. 75 FR 32773 - Auction of 218-219 MHz Service and Phase II 220 MHz Service Licenses Scheduled for December 7...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    ... certain portions of the electromagnetic spectrum or provide service to certain areas in their geographic..., Auctions and Spectrum Access Division: For auction legal questions: Sayuri Rajapakse at (202) 418-0660; for... 89 will include a total of 1,868 licenses. These include licenses for spectrum not previously...

  18. Elaboration and controlling excited state double proton transfer mechanism of 2,5-bis(benzoxazol-2-yl)thiophene-3,4-diol

    NASA Astrophysics Data System (ADS)

    Zhao, Jinfeng; Zheng, Yujun

    2017-03-01

    In the present work, we theoretically illuminate the excited state double proton transfer (ESDPT) process about a novel synthesized system 2,5-bis(benzoxazol-2-yl)thiophene-3,4-diol (BBTD). Minor changes of both structure and charge redistribution deriving from photoexcitation result in obviously different excited state dynamical process. Exploration about our constructed S1-state potential energy surface (PES) indicates a stepwise ESDPT mechanism for BBTD. In addition, we present a new mechanism about regulating and controlling stepwise ESDPT process via external electric field.

  19. Elaboration and controlling excited state double proton transfer mechanism of 2,5-bis(benzoxazol-2-yl)thiophene-3,4-diol

    PubMed Central

    Zhao, Jinfeng; Zheng, Yujun

    2017-01-01

    In the present work, we theoretically illuminate the excited state double proton transfer (ESDPT) process about a novel synthesized system 2,5-bis(benzoxazol-2-yl)thiophene-3,4-diol (BBTD). Minor changes of both structure and charge redistribution deriving from photoexcitation result in obviously different excited state dynamical process. Exploration about our constructed S1-state potential energy surface (PES) indicates a stepwise ESDPT mechanism for BBTD. In addition, we present a new mechanism about regulating and controlling stepwise ESDPT process via external electric field. PMID:28327590

  20. Resolution of concerted versus sequential mechanisms in photo-induced double-proton transfer reaction in 7-azaindole H-bonded dimer

    PubMed Central

    Catalán, Javier; del Valle, Juan Carlos; Kasha, Michael

    1999-01-01

    The experimental and theoretical bases for a synchronous or concerted double-proton transfer in centro-symmetric H-bonded electronically excited molecular dimers are presented. The prototype model is the 7-azaindole dimer. New research offers confirmation of a concerted mechanism for excited-state biprotonic transfer. Recent femtosecond photoionization and coulombic explosion techniques have given rise to time-of-flight MS observations suggesting sequential two-step biprotonic transfer for the same dimer. We interpret the overall species observed in the time-of-flight experiments as explicable without conflict with the concerted mechanism of proton transfer. PMID:10411876

  1. The conversion of cholest-7-en-3β-ol into cholesterol. General comments on the mechanism of the introduction of double bonds in enzymic reactions

    PubMed Central

    Dewhurst, S. Marsh; Akhtar, M.

    1967-01-01

    Convenient syntheses of 6β-tritiated Δ7-cholestenol and 3α-tritiated Δ7-cholestene-3β,5α-diol are described. It was shown that the conversion of 6β-tritiated Δ7-cholestenol into cholesterol is accompanied by the complete retention of label. It was unambiguously established that the overall reaction leading to the introduction of the double bond in the 5,6-position in cholesterol occurs via a cis-elimination involving the 5α- and 6α-hydrogen atoms and that during this process the 6β-hydrogen atom remains completely undisturbed. Metabolic studies with 3α-tritiated Δ7-cholestene-3β,5α-diol revealed that under anaerobic conditions the compound is not converted into cholesterol. This observation, coupled with the previous work of Slaytor & Bloch (1965), is interpreted to exclude a hydroxylation–dehydration mechanism for the origin of the 5,6-double bond in cholesterol. It was also shown that under aerobic conditions 3α-tritiated Δ7-cholestene-3β,5α-diol is efficiently converted into cholesterol and that this conversion occurs through the intermediacy of 7-dehydrocholesterol. Cumulative experimental evidence presented in this paper and elsewhere is used to suggest that the 5,6-double bond in cholesterol originates through an oxygen-dependent dehydrogenation process and a hypothetical mechanism for this and related reactions is outlined. PMID:16742545

  2. The impact of product information and trials on demand for smokeless tobacco and cigarettes: Evidence from experimental auctions

    PubMed Central

    Rousu, Matthew C.; O'Connor, Richard; Thrasher, James F; June, Kristie; Bansal-Travers, Maansi; Pitcavage, James

    2014-01-01

    Introduction Epidemiological and toxicological evidence suggests lower risk of smokeless tobacco (ST) products compared to cigarettes. Less is known, however, about consumer perceptions and use of novel forms of ST, including snus and dissolvable tobacco. Methods In this study, we conducted in-person experimental auctions in Buffalo, NY, Columbia, SC, and Selinsgrove, PA with 571 smokers to test the impact of information and product trials on smokers’ preferences. Auctions were conducted between November 2010-November 2011. Results We found no evidence of an impact of product trials on demand in our auctions. Anti-ST information increased demand for cigarettes when presented alone, but when presented with Pro-ST information it decreased demand for cigarettes. It did not decrease demand for ST products. Anti-smoking information increased demand for ST products, but did not affect cigarette demand. Conclusions These findings suggest that credible and effective communications about tobacco harm reduction should reinforce the negative effects of smoking. PMID:24321456

  3. Double Your Pleasure, Double Your Funds.

    ERIC Educational Resources Information Center

    McCall, Miles; Sitton, Bob

    1999-01-01

    Discusses a variety of fun activities that college and universities can develop as alumni fund-raising events: a golf tournament; scholarship auctions (silent, on-the-spot, live televised, and live); charitable raffles; duck dashes; themed banquets; and a tuition raffle. (MSE)

  4. Double Your Pleasure, Double Your Funds.

    ERIC Educational Resources Information Center

    McCall, Miles; Sitton, Bob

    1999-01-01

    Discusses a variety of fun activities that college and universities can develop as alumni fund-raising events: a golf tournament; scholarship auctions (silent, on-the-spot, live televised, and live); charitable raffles; duck dashes; themed banquets; and a tuition raffle. (MSE)

  5. Challenges posed to the traceability of weaner pigs following live auction.

    PubMed

    Sithole, F; Toribio, J; Schembri, N; Holyoake, P K

    2009-04-01

    To gather demographic data on live pig sales through a peri-urban saleyard in Camden, New South Wales, and to demonstrate the difficulties in tracing the subsequent movements of pigs, particularly weaner pigs. Records of pig sales held weekly at the Camden saleyards for the 2003/2004 and 2004/2005 financial years were analysed. Saleyard data on a number of variables were entered into a purpose-designed database. Distributions of pig sales according to pig class (weaner/porker/baconer/backfatter), purchaser type (butcher/non-butcher), and transaction type (cash/account) were determined. More weaners (3192 in 2003/2004 and 3940 in 2004/2005) were sold than any other class of pig, accounting for 45% of the total pigs sold during this period. During 2003/2004, 3802 pigs were bought by 329 non-butcher purchasers including 1631 weaners (43%) purchased by 153 non-butchers (47%). The majority of these non-butchers during the study period (86%) paid cash for their pigs and did not provide the necessary information to allow the end destination of pigs to be determined. Location data was available for all vendors but only 25% of purchasers. This study highlights the challenges posed in tracing movement of pigs following sale by auction. A high proportion of weaners sold at this peri-urban saleyard would not have been slaughtered immediately. This study highlights the potential difficulties in tracing pig movements after sale, for disease control purposes. We recommend that legislation be amended requiring the identification of weaner pigs sold live at auction in all states of Australia and the recording of the property identification code of all vendors and purchasers of pigs sold live at auction.

  6. The Allocation of Runway Slots by Auction. Volume I. Executive Summary.

    DTIC Science & Technology

    1980-04-15

    7.3 Net Earnings After Slot Payments, After Taxes 32 7.4 Small Communities Average Enplanements/Day 34 Vill I. BACKGROUND The Airline Deregulation Act...34 HUREAU OF TANDARLS 1%3 Volume I The Allocation ofRunway Slots by----IN__ Auction Office of Aviation Policy Washington, D.C. 20590 xecutive Summary...Princeton, NJ 08540 / DOT-FA79WA-4374 , 13 Type of Repor, end Ps.,od Co.e.ed 12. Sp.onseorn Agency Name and Addess Office of Aviation Policy Final Report

  7. A Winner Determination Algorithm for Combinatorial Auctions Based on Hybrid Artificial Fish Swarm Algorithm

    NASA Astrophysics Data System (ADS)

    Zheng, Genrang; Lin, ZhengChun

    The problem of winner determination in combinatorial auctions is a hotspot electronic business, and a NP hard problem. A Hybrid Artificial Fish Swarm Algorithm(HAFSA), which is combined with First Suite Heuristic Algorithm (FSHA) and Artificial Fish Swarm Algorithm (AFSA), is proposed to solve the problem after probing it base on the theories of AFSA. Experiment results show that the HAFSA is a rapidly and efficient algorithm for The problem of winner determining. Compared with Ant colony Optimization Algorithm, it has a good performance with broad and prosperous application.

  8. Dielectric relaxation and electrical conduction mechanism in A2HoSbO6 (A=Ba, Sr, Ca) Double Perovskite Ceramics: An impedance spectroscopic analysis

    NASA Astrophysics Data System (ADS)

    Halder, Saswata; Dutta, Alo; Sinha, T. P.

    2017-03-01

    The AC electrical properties of polycrystalline double perovskite oxides A2HoSbO6 (A=Ba, Sr, Ca; AHS) synthesized by solid state reaction technique has been explored by using impedance spectroscopic studies. The Rietveld refinement of the room temperature X-ray diffraction data show that Ba2HoSbO6 (BHS) has cubic phase and Sr2HoSbO6 (SHS) and Ca2HoSbO6 (CHS) crystallize in monoclinic phase. The samples show significant frequency dispersion in their dielectric properties. The polydispersive nature of the relaxation mechanism is explained by the modified Cole-Cole model. The scaling behavior of dielectric loss indicate the temperature independence of the relaxation mechanism. The magnitude of the activation energy indicates that the hopping mechanism is responsible for carrier transport in AHS. The frequency dependent conductivity spectra follow the double power law. Impedance spectroscopic data presented in the Nyquist plot (Z" versus Z‧) are used to identify an equivalent circuit along with to know the grain, grain boundary and interface contributions. The constant phase element (CPE) is used to analyze the experimental response of BHS, SHS and CHS comprehending the contribution of different microstructural features to the conduction process. The temperature dependent electrical conductivity shows a semiconducting behavior.

  9. An Effective Power Saving Mechanism for IEEE 802.11 PSM in Double-Layered Mobile P2P Systems

    NASA Astrophysics Data System (ADS)

    Lee, Ju-Hee; Kim, Taek-Hun; Song, Jin-Woo; Lee, Kwang-Jo; Yang, Sung-Bong

    In this paper, we propose a scheme for double-layered mobile P2P systems that enhances energy efficiency by modifying PSM(Power Saving Mode) defined in 802.11. The proposed scheme lengthens the beacon interval adaptively and adopts a known power saving scheme for more power saving. The experimental results showed that the proposed scheme improved 58.3% in terms of the average energy saving and 10% in terms of the average success ratio for file searches over the system with the standard PSM.

  10. Double metalization for VLSI

    NASA Technical Reports Server (NTRS)

    Trotter, J. D.; Wade, T. E.

    1980-01-01

    Postsintering process increases yield of double-layer metal conductors to almost 100 percent. When wafers containing double-metalized chips are sintered, metal layers react with oxide film remaining in insulation layer holes, breaking it up so that it no longer impedes electric current. Cooling also mechanically disrupts oxide film.

  11. Replication-dependent and transcription-dependent mechanisms of DNA double-strand break induction by the topoisomerase 2-targeting drug etoposide.

    PubMed

    Tammaro, Margaret; Barr, Peri; Ricci, Brett; Yan, Hong

    2013-01-01

    Etoposide is a DNA topoisomerase 2-targeting drug widely used for the treatment of cancer. The cytoxicity of etoposide correlates with the generation of DNA double-strand breaks (DSBs), but the mechanism of how it induces DSBs in cells is still poorly understood. Catalytically, etoposide inhibits the re-ligation reaction of Top2 after it nicks the two strands of DNA, trapping it in a cleavable complex consisting of two Top2 subunits covalently linked to the 5' ends of DNA (Top2cc). Top2cc is not directly recognized as a true DSB by cells because the two subunits interact strongly with each other to hold the two ends of DNA together. In this study we have investigated the cellular mechanisms that convert Top2ccs into true DSBs. Our data suggest that there are two mechanisms, one dependent on active replication and the other dependent on proteolysis and transcription. The relative contribution of each mechanism is affected by the concentration of etoposide. We also find that Top2α is the major isoform mediating the replication-dependent mechanism and both Top2α and Top2 mediate the transcription-dependent mechanism. These findings are potentially of great significance to the improvement of etoposide's efficacy in cancer therapy.

  12. Replication-Dependent and Transcription-Dependent Mechanisms of DNA Double-Strand Break Induction by the Topoisomerase 2-Targeting Drug Etoposide

    PubMed Central

    Tammaro, Margaret; Barr, Peri; Ricci, Brett; Yan, Hong

    2013-01-01

    Etoposide is a DNA topoisomerase 2-targeting drug widely used for the treatment of cancer. The cytoxicity of etoposide correlates with the generation of DNA double-strand breaks (DSBs), but the mechanism of how it induces DSBs in cells is still poorly understood. Catalytically, etoposide inhibits the re-ligation reaction of Top2 after it nicks the two strands of DNA, trapping it in a cleavable complex consisting of two Top2 subunits covalently linked to the 5’ ends of DNA (Top2cc). Top2cc is not directly recognized as a true DSB by cells because the two subunits interact strongly with each other to hold the two ends of DNA together. In this study we have investigated the cellular mechanisms that convert Top2ccs into true DSBs. Our data suggest that there are two mechanisms, one dependent on active replication and the other dependent on proteolysis and transcription. The relative contribution of each mechanism is affected by the concentration of etoposide. We also find that Top2α is the major isoform mediating the replication-dependent mechanism and both Top2α and Top2 mediate the transcription-dependent mechanism. These findings are potentially of great significance to the improvement of etoposide’s efficacy in cancer therapy. PMID:24244448

  13. Spectrum sharing in cognitive radio networks--an auction-based approach.

    PubMed

    Wang, Xinbing; Li, Zheng; Xu, Pengchao; Xu, Youyun; Gao, Xinbo; Chen, Hsiao-Hwa

    2010-06-01

    Cognitive radio is emerging as a promising technique to improve the utilization of the radio frequency spectrum. In this paper, we consider the problem of spectrum sharing among primary (or "licensed") users (PUs) and secondary (or "unlicensed") users (SUs). We formulate the problem based on bandwidth auction, in which each SU makes a bid for the amount of spectrum and each PU may assign the spectrum among the SUs by itself according to the information from the SUs without degrading its own performance. We show that the auction is a noncooperative game and that Nash equilibrium (NE) can be its solution. We first consider a single-PU network to investigate the existence and uniqueness of the NE and further discuss the fairness among the SUs under given conditions. Then, we present a dynamic updating algorithm in which each SU achieves NE in a distributed manner. The stability condition of the dynamic behavior for this spectrum-sharing scheme is studied. The discussion is generalized to the case in which there are multiple PUs in the network, where the properties of the NE are shown under appropriate conditions. Simulations were used to evaluate the system performance and verify the effectiveness of the proposed algorithm.

  14. The impact of free trial acceptance on demand for alternative nicotine products: evidence from experimental auctions.

    PubMed

    Rousu, Matthew C; O'Connor, Richard J; Bansal-Travers, Maansi; Pitcavage, James M; Thrasher, James F

    2015-06-11

    This study explored the relationship between product trials and consumer demand for alternative nicotine products (ANP). An experimental auction was conducted with 258 adult smokers, wherein participants were randomly assigned to one of four experimental conditions. The participants received the opportunity to try, but did not have to accept, one of three relatively novel ST products (i.e., snus, dissolvable tobacco, or medicinal nicotine), or they were placed into a control group (i.e., no trial). All the participants then bid on all three of these products, as well as on cigarettes. We assessed interest in using ANP based on both trial of the product and bids placed for the products in the experimental auction. Fewer smokers were willing to try snus (44%) than dissolvable tobacco (64%) or medicine nicotine (68%). For snus, we find modest evidence suggesting that willingness to try is associated with greater demand for the product. For dissolvable tobacco or medicinal nicotine, we find no evidence that those who accept the product trial have higher demand for the product. Free trials of a novel ANP were not strongly associated with product demand, as assessed by willingness to pay. Given the debate over the potential for ANP to reduce the harm from smoking, these results are important in understanding the impact of free trial offers on adoption of ST product as a strategy to reduce harm from tobacco use.

  15. Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action.

    PubMed

    Chukwudi, Chinwe U; Good, Liam

    2016-08-01

    The 16S rRNA binding mechanism proposed for the antibacterial action of the tetracyclines does not explain their mechanism of action against non-bacterial pathogens. In addition, several contradictory base pairs have been proposed as their binding sites on the 16S rRNA. This study investigated the binding of minocycline and doxycycline to short double-stranded RNAs (dsRNAs) of random base sequences. These tetracyclines caused a dose-dependent decrease in the fluorescence intensities of 6-carboxyfluorescein (FAM)-labelled dsRNA and ethidium bromide (EtBr)-stained dsRNA, indicating that both drugs bind to dsRNA of random base sequence in a manner that is competitive with the binding of EtBr and other nucleic acid ligands often used as stains. This effect was observable in the presence of Mg(2+). The binding of the tetracyclines to dsRNA changed features of the fluorescence emission spectra of the drugs and the CD spectra of the RNA, and inhibited RNase III cleavage of the dsRNA. These results indicate that the double-stranded structures of RNAs may have a more important role in their interaction with the tetracyclines than the specific base pairs, which had hitherto been the subject of much investigation. Given the diverse functions of cellular RNAs, the binding of the tetracyclines to their double-stranded helixes may alter the normal processing and functioning of the various biological processes they regulate. This could help to explain the wide range of action of the tetracyclines against various pathogens and disease conditions.

  16. 75 FR 22792 - Closed Auction of Broadcast Construction Permits Scheduled for July 20, 2010; Notice and Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... guarantee of business success. iv. Use of Integrated Spectrum Auction System 27. The Commission will make... deadline, such as the acquisition of attributable interests in media of mass communications, may cause... deadline. Thus, any change in control of an applicant, resulting from a merger, for example, will be...

  17. 76 FR 21350 - Auction of 700 MHz Band Licenses Scheduled for July 19, 2011; Notice and Filing Requirements...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... such geographic area licensees to use certain portions of the electromagnetic spectrum or provide... of the electromagnetic spectrum or provide ] service to certain areas in their geographic license... Telecommunications Bureau, Auctions and Spectrum Access Division: For legal questions: Lynne Milne at (202)...

  18. 30 CFR 285.308 - How will MMS conduct an auction for ROW grants and RUE grants?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and RUE grants? 285.308 Section 285.308 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING... Renewable Energy Activities Obtaining Row Grants and Rue Grants § 285.308 How will MMS conduct an auction...

  19. 30 CFR 285.308 - How will MMS conduct an auction for ROW grants and RUE grants?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How will MMS conduct an auction for ROW grants and RUE grants? 285.308 Section 285.308 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL...

  20. 40 CFR 97.721 - Recordation of TR SO2 Group 2 allowance allocations and auction results.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Recordation of TR SO2 Group 2 allowance allocations and auction results. 97.721 Section 97.721 Protection of Environment ENVIRONMENTAL... control period in 2014 and 2015. (d) By July 1, 2014, the Administrator will record in each TR SO2 Group 2...

  1. 40 CFR 97.621 - Recordation of TR SO2 Group 1 allowance allocations and auction results.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Recordation of TR SO2 Group 1 allowance allocations and auction results. 97.621 Section 97.621 Protection of Environment ENVIRONMENTAL... control period in 2014 and 2015. (d) By July 1, 2014, the Administrator will record in each TR SO2 Group 1...

  2. 49 CFR 599.402 - Requirements and limitations for salvage auctions that are consigned trade-in vehicles under the...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Requirements and limitations for salvage auctions that are consigned trade-in vehicles under the CARS program. 599.402 Section 599.402 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED)...

  3. 49 CFR 599.402 - Requirements and limitations for salvage auctions that are consigned trade-in vehicles under the...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Requirements and limitations for salvage auctions that are consigned trade-in vehicles under the CARS program. 599.402 Section 599.402 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED)...

  4. 81 FR 3465 - Notice of Realty Action: Proposed Competitive Sealed-Bid, Oral Auction Sale and Segregation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2016-01-21

    ... Competitive Sealed-Bid, Oral Auction Sale and Segregation of Public Land in Owyhee County, ID AGENCY: Bureau... to offer a parcel of public land totaling 120.84 acres in Owyhee County, Idaho, by competitive sealed... sale is consistent with the 1999 Owyhee Resource Management Plan (RMP), Record of Decision,...

  5. 77 FR 22575 - The Auction Block Company, an Alaska Corporation v. the City of Homer, a Municipal Corporation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-16

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION The Auction Block Company, an Alaska Corporation v. the City of Homer, a Municipal Corporation and Its Port of Homer; Notice of Filing of Complaint and Assignment Notice is given that a complaint has been...

  6. 78 FR 50086 - Notice of Competitive Auction for Solar Energy Development on Public Lands in the State of Colorado

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... Bureau of Land Management Notice of Competitive Auction for Solar Energy Development on Public Lands in... applicant to submit a right-of-way (ROW) application and a plan of development for solar energy projects on... solicitations of interest and ROW applications within two designated Solar Energy Zones (SEZ): Los Mogotes East...

  7. The influence of an online auction's product price and e-retailer reputation on consumers' perception, attitude, and behavioral intention.

    PubMed

    Wu, Wann-Yih; Huang, Po-Ching; Fu, Chen-Su

    2011-06-01

    Online auctions combine the conventional auction model with information technology. However, information asymmetry within such auctions causes risks and uncertainties that influence consumer purchase intentions. In this study, a 2 (product price: high vs. low) × 2 (e-retailer reputation: high vs. low) experimental design was used to understand whether the product price and e-retailer reputation will influence consumers' perceived risk, attitude toward the website and purchase intention. The results of this study indicate that perceived risk negatively influences consumer attitude toward the website and online purchase intention, while consumer attitude toward the website positively influences purchase intention. Moreover, involvement moderates the influence of product price and e-retailer reputation only on social risk but does not have a significant effect on consumer attitude toward the website. This study contributes to a more comprehensive understanding of online auction users' behavior. Finally, the managerial implications, limitations and future research directions are also provided. © 2011 The Authors. Scandinavian Journal of Psychology © 2011 The Scandinavian Psychological Associations.

  8. 75 FR 38545 - Notice of Realty Action: Competitive Auction of Public Lands in White Pine County, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... Bureau of Land Management [LLNVL01000 L14300000.EU0000 241A; N-86667; 10-08807; MO 4500012445; TAS: 14X5232] Notice of Realty Action: Competitive Auction of Public Lands in White Pine County, NV AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Realty Action. SUMMARY: The Bureau of...

  9. 47 CFR 27.1213 - Designated entity provisions for BRS in Commission auctions commencing prior to January 1, 2004.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Designated entity provisions for BRS in Commission auctions commencing prior to January 1, 2004. 27.1213 Section 27.1213 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS...

  10. 47 CFR 27.1213 - Designated entity provisions for BRS in Commission auctions commencing prior to January 1, 2004.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Designated entity provisions for BRS in Commission auctions commencing prior to January 1, 2004. 27.1213 Section 27.1213 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS...

  11. 47 CFR 27.1213 - Designated entity provisions for BRS in Commission auctions commencing prior to January 1, 2004.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Designated entity provisions for BRS in Commission auctions commencing prior to January 1, 2004. 27.1213 Section 27.1213 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS...

  12. 76 FR 76174 - Request for Information on the State of the Offshore Renewable Energy Industry-Auction Format...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... Bureau of Ocean Energy Management Request for Information on the State of the Offshore Renewable Energy... auction formats which may be used to issue commercial renewable energy leases on the Outer Continental... offshore renewable energy industry, including economic matters that promote or detract from continued...

  13. 78 FR 72081 - Closed Auction of AM Broadcast Construction Permits Scheduled for May 6, 2014; Comment Sought on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... number, for example, DA 13-2168. The Auction 84 Comment Public Notice and related documents also are... will be awarded for each MX group identified in Attachment A. III. Due Diligence 4. Each potential... existence of pending administrative or judicial proceedings that might affect its decisions regarding...

  14. Mechanism of adsorption of single and double stranded DNA on gold and silver nanoparticles: Investigating some important parameters in bio-sensing applications.

    PubMed

    Farkhari, Nahid; Abbasian, Sara; Moshaii, Ahmad; Nikkhah, Maryam

    2016-12-01

    The mechanism of adsorption of single and double stranded DNAs on colloidal gold and silver nanoparticles has been studied by measuring the resistance of the nanoparticles, surrounded by various oligonucleotides, against salt induced aggregation. It is shown that both single and double stranded DNAs can be adsorbed on the metal nanoparticles and the adsorption strength is determined by the interaction between various bases of DNA and the nanoparticles. By changing the salt concentration, the difference between adsorption of various DNA strands on the nanoparticles can be specified. The results indicate that a key parameter in success of a sensing assay of DNA hybridization is the salt concentration which should be greater than a minimum threshold depending on the nanoparticles characteristics. We have also investigated the interaction mechanism between various DNA bases with the metal nanoparticles. For both gold and silver nanoparticles, adenine has the highest and thymine has the lowest attachment to the nanoparticles. From surface enhanced Raman spectroscopy (SERS) data of various bases in the presence of gold nanoparticles, the probable interaction points in the bases with the nanoparticles have been determined, which are mainly the nitrogen sites of these oligonucleotides. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Double-Network Hydrogel with Tunable Mechanical Performance and Biocompatibility for the Fabrication of Stem Cells-Encapsulated Fibers and 3D Assemble

    PubMed Central

    Liang, Zhe; Liu, Chenguang; Li, Lili; Xu, Peidi; Luo, Guoan; Ding, Mingyu; Liang, Qionglin

    2016-01-01

    Fabrication of cell-encapsulated fibers could greatly contribute to tissue engineering and regenerative medicine. However, existing methods suffered from not only unavoidability of cell damaging conditions and/or sophisticated equipment, but also unavailability of proper materials to satisfy both mechanical and biological expectations. In this work, a simple method is proposed to prepare cell-encapsulated fibers with tunable mechanical strength and stretching behavior as well as diameter and microstructure. The hydrogel fibers are made from optimal combination of alginate and poly(N-iso-propylacrylamide)-poly(ethylene glycol), characteristics of double-network hydrogel, with enough stiffness and flexibility to create a variety of three dimensional structures like parallel helical and different knots without crack. Furthermore, such hydrogel fibers exhibit better compatibility as indicated by the viability, proliferation and expression of pluripotency markers of embryonic stem cells encapsulated after 4-day culture. The double-network hydrogel possesses specific quick responses to either of alginate lyase, EDTA or lower environmental temperature which facilitate the optional degradation of fibers or fibrous assemblies to release the cells encapsulated for subsequent assay or treatment. PMID:27628933

  16. Modeling effects of gas bubbles on the mechanical behaviors of Ag/Bi-2212 round wires using a double cantilever beam bridge model

    NASA Astrophysics Data System (ADS)

    Lu, Yurong; Wang, Zhongtong; Yong, Huadong; Zhou, Youhe

    2016-07-01

    Due to the larger current-carrying property, Bi2Sr2CaCu2Ox (Bi2212) superconductors have a great potential application in high field magnet. Bi2212 superconducting material can be fabricated as an isotropic round wire. However, there is 30% void space in the wire, such as gas bubbles. The void space has a larger influence on the property of the wire. In this paper, we will study the effect of gas bubble on the fracture behavior. Based on the double cantilever beam model and critical state theory, the mechanical behavior of Bi2212 wire is studied for decreasing field. Two different damage mechanisms are discussed using the strain energy release rate and strain of bridge. The results show that the large gas bubble can increase the strain of bridge. The central filaments with gas bubble are easier to be damaged than the edge filaments with gas bubble.

  17. The mechanical properties and cytotoxicity of cell-laden double-network hydrogels based on photocrosslinkable gelatin and gellan gum biomacromolecules

    PubMed Central

    Shin, Hyeongho; Olsen, Bradley D.; Khademhosseini, Ali

    2012-01-01

    A major goal in the application of hydrogels for tissue engineering scaffolds, especially for load-bearing tissues such as cartilage, is to develop hydrogels with high mechanical strength. In this study, a double-network (DN) strategy was used to engineer strong hydrogels that can encapsulate cells. We improved upon previously studied double-network (DN) hydrogels by using a processing condition compatible with cell survival. The DN hydrogels were created by a two-step photocrosslinking using gellan gum methacrylate (GGMA) for the rigid and brittle first network, and gelatin methacrylamide (GelMA) for the soft and ductile second network. We controlled the degree of methacrylation of each polymer so that they obtain relevant mechanical properties as each network. The DN was formed by photocrosslinking the GGMA, diffusing GelMA into the first network, and photocrosslinking the GelMA to form the second network. The formation of the DN was examined by diffusion tests of the large GelMA molecules into the GGMA network, the resulting enhancement in the mechanical properties, and the difference in mechanical properties between GGMA/GelMA single networks (SN) and DNs. The resulting DN hydrogels exhibited the compressive failure stress of up to 6.9 MPa, which approaches the strength of cartilage. It was found that there is an optimal range of the crosslink density of the second network for high strength of DN hydrogels. DN hydrogels with a higher mass ratio of GelMA to GGMA exhibited higher strength, which shows promise in developing even stronger DN hydrogels in the future. Three dimensional (3D) encapsulation of NIH-3T3 fibroblasts and the following viability test showed the cell-compatibility of the DN formation process. Given the high strength and the ability to encapsulate cells, the DN hydrogels made from photocrosslinkable macromolecules could be useful for the regeneration of load-bearing tissues. PMID:22265786

  18. The mechanical properties and cytotoxicity of cell-laden double-network hydrogels based on photocrosslinkable gelatin and gellan gum biomacromolecules.

    PubMed

    Shin, Hyeongho; Olsen, Bradley D; Khademhosseini, Ali

    2012-04-01

    A major goal in the application of hydrogels for tissue engineering scaffolds, especially for load-bearing tissues such as cartilage, is to develop hydrogels with high mechanical strength. In this study, a double-network (DN) strategy was used to engineer strong hydrogels that can encapsulate cells. We improved upon previously studied double-network (DN) hydrogels by using a processing condition compatible with cell survival. The DN hydrogels were created by a two-step photocrosslinking using gellan gum methacrylate (GGMA) for the rigid and brittle first network, and gelatin methacrylamide (GelMA) for the soft and ductile second network. We controlled the degree of methacrylation of each polymer so that they obtain relevant mechanical properties as each network. The DN was formed by photocrosslinking the GGMA, diffusing GelMA into the first network, and photocrosslinking the GelMA to form the second network. The formation of the DN was examined by diffusion tests of the large GelMA molecules into the GGMA network, the resulting enhancement in the mechanical properties, and the difference in mechanical properties between GGMA/GelMA single networks (SN) and DNs. The resulting DN hydrogels exhibited the compressive failure stress of up to 6.9 MPa, which approaches the strength of cartilage. It was found that there is an optimal range of the crosslink density of the second network for high strength of DN hydrogels. DN hydrogels with a higher mass ratio of GelMA to GGMA exhibited higher strength, which shows promise in developing even stronger DN hydrogels in the future. Three dimensional (3D) encapsulation of NIH-3T3 fibroblasts and the following viability test showed the cell-compatibility of the DN formation process. Given the high strength and the ability to encapsulate cells, the DN hydrogels made from photocrosslinkable macromolecules could be useful for the regeneration of load-bearing tissues. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. [Lethal effect after transmutation of 33P incorporated into bacteriophage S 13 and mechanisms of DNA double helix rupture].

    PubMed

    Apelgot, S

    1980-04-01

    The experiments show the lethal effect of the beta decay of 33P incorporated in DNA of bacteriophage S 13. The lethal efficiency is high, 0.72 at 0 degrees C and 0.55 at--197 degrees C. The presence of a radical scavenger like AET has no influence. It was found previously that for such phages with single-stranded DNA, the lethal efficiency of 32P decay is unity, and that the lethal event is a DNA single-strand break, owing to the high energy of the nucleogenic 32S atom. As the recoil energy of the 33S atom is too low to account for such a break, it is suggested that the reorganization of the phosphate molecule into sulphate is able to bring about a DNA single-strand break with an efficiency as high as 0.7, at 0 degrees C. A model for the DNA double-strand-break produced by a transmutation processes is suggested.

  20. Human remains sold to the highest bidder! A snapshot of the buying and selling of human skeletal remains on eBay, an Internet auction site.

    PubMed

    Huxley, Angie K; Finnegan, Michael

    2004-01-01

    Internet auction sites have become increasingly popular, with diverse items up for sale to the public worldwide. The purposes of this paper are to inform the forensic community that human skeletal remains, old and new, are for sale on the eBay internet auction site, and to advise forensic scientists that eBay does not use a forensic anthropologist to assess photographs of these materials. Over the last few years, this website was "surfed," with numerous auctions during this period. After contacting eBay by email, representatives responded that they adhere to Native American Grave Protection and Repatriation Act (NAGPRA) and that their website indicates that auctions must state that sale of human remains is for instructional purposes only. Based on the photographs, the remains appear to be of prehistoric and modern origin. An unfortunate consequence of such sale may generate interest in stealing remains from graves, mortuaries, hospitals, or county morgues worldwide.