Sample records for dr brian cox

  1. Maniac Talk - Dr. Brian Dennis

    NASA Image and Video Library

    2014-09-24

    Brian Dennis Maniac Lecture, September 24, 2014 NASA Solar Physicist Dr. Brian Dennis presented a Maniac Talk entitled "From Picking Potatoes to Measuring the Biggest Bangs in the Solar System -- Always a Farm Boy!" Brian described his formative years in England, then summarized our present understanding of how solar flares work and reviewed possible advances in instrumentation that could lead to major breakthroughs in the future.

  2. The Children's Inn at NIH - Three Stories | NIH MedlinePlus the Magazine

    MedlinePlus

    ... in the school environment." Dr. Brian Brooks—The Team Co-Leader Dr. Brian Brooks uses a puppet ... much experience with." He coordinates a multi-disciplinary team of researchers, geneticists, nurses, counselors, and patients' families— ...

  3. Analyst Performance Measures. Volume 2: Information Quality Tools for Persistent Surveillance Data Sets

    DTIC Science & Technology

    2011-10-01

    Marina Altynova Ed Wasser Telford Berkey Dr. Sanjay Boddhu Tin Sa Qbase, LLC 2619 Commons Boulevard Dayton OH 45431 Brian Tsou Forecasting...Altynova, Ed Wasser , Telford Berkey, Dr. Sanjay Boddhu, Tin Sa, Brian Tsou 5d. PROJECT NUMBER 7184 5e. TASK NUMBER 06 5f. WORK UNIT NUMBER

  4. Is the 'Cox effect' good for us?

    NASA Astrophysics Data System (ADS)

    Mellor, Felicity

    2012-10-01

    Some claim that recent increases in the number of students studying physics in the UK are due to the TV appearances of physicist Brian Cox. But as Felicity Mellor warns, the "Cox effect" may not be all good news.

  5. Who Do You Think You Are?

    ERIC Educational Resources Information Center

    Banerji, Shilpa

    2005-01-01

    Harvard psychologist Dr. Mahzarin R. Banaji is helping explore the world of subconscious bias with the Implicit Association Test (IAT). Banaji teamed up with fellow psychology professors Dr. Anthony Greenwald of the University of Washington and Dr. Brian Nosek of the University of Virginia to develop the IAT. The IAT was created as a tool to…

  6. SSC San Diego Command History Calendar Year 2006

    DTIC Science & Technology

    2007-03-01

    Year: Dr. Visarath In, Yong Kho, Dr. Adi Bulsara, Dr. Joseph Neff, Dr. Brian Meadows, “Self-Induced Oscillations in Coupled Fluxgate Magnetometer : A... digital assistant. The USCG’s Underwater Port Security Working Group reviews ongoing efforts and provides direction to the USCG and the Department...provides the data link gateway as the JDN communications equipment that is used in MDSE to exchange Tactical Digital Information Link (TADIL) J, Satellite

  7. Architecting Human Operator Trust in Automation to Improve System Effectiveness in Multiple Unmanned Aerial Vehicles (UAV) Control

    DTIC Science & Technology

    2009-03-01

    like to extend our appreciation to our research sponsor Dr. Janet Miller from the Air Force Research Labs, and her colleague Dr. Cheryl Batchelor, for...for single-operator control of multiple UAVs. Drs. Brian Tsou, Lamar Warfield , Justin Estepp and Benjamin Knott , meanwhile, contributed to our

  8. Sesquinaries, Magnetics and Atmospheres: Studies of the Terrestrial Moons and Exoplanets

    DTIC Science & Technology

    2016-12-01

    support provided by Red Sky Research, LLC. Computational support was provided by the NASA Ames Mission Design Division (Code RD) for research...Systems Branch (Code SST), NASA Ames Research Center, provided supercomputer access and computational resources for the work in Chapter 5. I owe a...huge debt of gratitude to Dr. Pete Worden, Dr. Steve Zornetzer, Dr. Alan Weston ( NASA ), and Col. Carol Welsch, Lt. Col Joe Nance and Lt. Col Brian

  9. 77 FR 12568 - Fishing Capacity Reduction Program for the Southeast Alaska Purse Seine Salmon Fishery

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... 99921 23 TREINEN CHARLES W... 60055 2054 ARLINGTON DR... ANCHORAGE AK 99517 24 SIMPSON BRIAN... SVENSON MIKE W...... 56237 104 SHARON DR....... SITKA AK 99835 269 OLSON CHARLES R..... 55989 3009 HALIBUT... KODIAK AK 99615 291 CHRISTENSEN CHARLES 56722 BOX 824 PETERSBURG AK 99833 L. 292 MATHISEN WAYNE T...

  10. Coastal Storm Surge Analysis: Storm Forcing. Report 3. Intermediate Submission No. 1.3

    DTIC Science & Technology

    2013-07-01

    No. 1.3 C oa st al a n d H yd ra u lic s La b or at or y Peter Vickery, Dhiraj Wadhera, Andrew Cox, Vince Cardone , Jeffrey Hanson, and Brian...Andrew Cox and Vince Cardone Oceanweather, Inc 5 River Road, Suite 1 Cos Cob, CT 06807 Jeffrey L. Hanson Field Research Facility US Army Engineer...Zou Modeling Mesh Modeling Mesh Modeling Mesh Elizabeth City State University Jinchun Yuan Web/GIS Oceanweather Vince Cardone Andrew Cox Wind

  11. Structural Optimization of a Distributed Actuation System in a Flexible In-Plane Morphing Wing

    DTIC Science & Technology

    2007-06-01

    Captain, USAF Approved: /signed/ 11 Jun 2007 Dr. Robert Canfield (Chairman) date /signed/ 11 Jun 2007 Dr. Brian Sanders (Member) date /signed/ 11 Jun...can be seen here at the Camp Roberts Flight Test Range [11]. separation, which ultimately increased the overall lift. During wind tunnel tests, the...Matlabr . The outermost loop was written by Mark Spillman and Dr. Robert Canfield and was based on Schittkowski’s Sequential Quadratic Programming (SQP

  12. Influence of Geometry on a High Surface Area-Solid Phase Microextraction Sampler for Chemical Vapor Collection

    DTIC Science & Technology

    2007-06-04

    LCDR Greg Cook , PhD Date...Science Research Unit • Dr. Robert Mustacich of RVM Scientific • My thesis advisory committee: LtCol Peter LaPuma, LCDR Greg Cook , and Dr. Brian...which constitutes a mass spectrum. A computer compares the mass spectrum to a mass spectral library like a fingerprint. (McMaster and McMaster, 1997

  13. Coastal Storm Surge Analysis: Modeling System Validation. Report 4: Intermediate Submission No. 2.0

    DTIC Science & Technology

    2013-07-01

    Oceanweather Vince Cardone Andrew Cox Wind Field Reconstructions Renaissance Computing Institute (RENCI) Brian Blanton Lisa Stillwell Kevin...Greenwood, V. J. Cardone , and V. R. Swail. 1995. An interactive objective kinematic analysis system. In Proceedings of the 4th International Workshop...A. Cox, V. Cardone , J. Hanson, and B. Blanton. Coastal storm surge analysis: Storm forcing, Submittal 1.3 to FEMA. In preparation. Vicksburg, MS

  14. Losartan reverses COX-2-dependent vascular dysfunction in offspring of hyperglycaemic rats.

    PubMed

    de Queiroz, Diego Barbosa; Ramos-Alves, Fernanda Elizabethe; Santos-Rocha, Juliana; Duarte, Gloria Pinto; Xavier, Fabiano Elias

    2017-09-01

    This study examined whether chronic treatment with losartan, an angiotensin II type 1 receptor (AT 1 R) antagonist, might reverse COX-2-mediated vascular dysfunction in mesenteric resistance arteries (MRA) from offspring of hyperglycaemic rats. Male 12-month-old offspring of hyperglycaemic (O-DR) and normoglycaemic (O-CR) rats were treated with losartan (15mg·kg·day -1 ) during 2months. Third order MRA of untreated and losartan-treated O-DR and O-CR were mounted in wire myograph for isometric tension measurements. COX-2 expression was analyzed by Western blot; TxA 2 , PGE 2 and PGF 2α release was measured using commercial kits. O-DR showed increased blood pressure, impaired acetylcholine-induced vasodilation and increased noradrenaline-induced vasoconstriction than O-CR. All these parameters were normalized by losartan in O-DR. Pre-incubation of MRA with indomethacin (COX-1/2 inhibitor), NS-398 (COX-2 inhibitor) or tempol (superoxide dismutase mimetic) increased relaxation to acetylcholine and reduced contraction to noradrenaline only in O-DR. COX-2 expression, TxA 2 , PGE 2 and PGF 2α release were increased in O-DR. In losartan-treated O-DR, NS-398, indomethacin or tempol failed to produce any effect on acetylcholine or noradrenaline responses. Losartan treatment reduced COX-2 expression, TxA 2 , PGE 2 and PGF 2α release in O-DR. The present results reveal that chronic losartan administration in O-DR normalizes endothelial function in MRA by correcting the existing COX-2 overexpression and the imbalance between endothelium-derived relaxing and contracting factors. These findings not only support the beneficial effects of AT 1 receptor antagonist in O-DR, but also suggest the implication of angiotensin II as a putative mediator of hyperglycemia-programmed vascular dysfunction in rats. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. People

    NASA Astrophysics Data System (ADS)

    2005-07-01

    WORLD YEAR OF PHYSICS Physics around the world: America Julio Benegas, Don Metz, Jesús Vázquez-Abad, Eduardo Molto, Josip Slisko and Rick Holmes INTERVIEW Things can only get better: a rock star tells of his hopes for popular physics David Smith talks to Brian Cox

  16. Gigabit Nectar: Architecture and Performance.

    DTIC Science & Technology

    1995-09-01

    proposed American National Standard for Information Systems, 1992. [3] Jose Arabe, Adam Beguelin, Bruce Lowekamp, Eric Seligman , Mike Starkey, and Peter...Shekhar Borkar, Robert Cohn, George Cox, Sha Gleason, Thomas Gross, H. T. Kung, Monica Lam, Brian Moore, Craig Peterson, John Pieper, Linda Rankin, P

  17. The Cyber Defense Review. Volume 1, Number 1, Spring 2016

    DTIC Science & Technology

    2016-04-20

    in the Land and Cyber Domains Lieutenant General Edward C. Cardon The U.S. Navy’s Evolving Cyber/ Cybersecurity Story Rear Admiral Nancy Norton...Olav Lysne Cyber Situational Awareness Maj. Gen. Earl D. Matthews, USAF, Ret Dr. Harold J. Arata III Mr. Brian L. Hale Is There a Cybersecurity ...Kallberg The Decision to Attack: Military and Intelligence Cyber Decision-Making by Dr. Aaron F. Brantly The Cyber Defense Review

  18. Directory of Manufacturing Research Centers

    DTIC Science & Technology

    1989-06-01

    Martin W. 51 Graff, Karl 176 Dornfeld, David 88 Gray, James 76 Doty, Keith 119 Gray, Vic 6 Driels, Morris 142 Green Jr., Robert E. 51 Drury , Colin 39...Buffalo Dr. Colin Drury , Executive Director Mr. Brian Kleiner, Administrative Director Technical areas include cost analysis, strategic planning

  19. Coastal Storm Surge Analysis: Storm Surge Results. Report 5: Intermediate Submission No. 3

    DTIC Science & Technology

    2013-11-01

    Vickery, P., D. Wadhera, A. Cox, V. Cardone , J. Hanson, and B. Blanton. 2012. Coastal storm surge analysis: Storm forcing (Intermediate Submission No...CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Jeffrey L. Hanson, Michael F. Forte, Brian Blanton

  20. Use of Recombinant Factor VIIA for Control of Combat-Related Haemorrhage

    DTIC Science & Technology

    2010-02-25

    Pallav Bhatnagar, Henno Schoombee, Brian Burgess Southend University Hospital, NHS Foundation Trust, Westcliff -on-Sea, Essex, UK Correspondence to Dr...transfusion requirements, did not result in better survival.11 1San Diego State University , School of Social Work, San Diego, USA 2Health Solutions

  1. The Role of Simulation in Test and Evaluation

    DTIC Science & Technology

    2010-01-01

    manual N MUM platform (handshake) checklist N Operational test agency milestone C assessment report input N Recorded mission vignettes (LUT training re...Journal Acknowledgments AB3 FDT&E test team (Figure 5): MAJ Cornelius L. Allen, Jr. (test officer), Dr. Bruce Wardlow (analyst), LTC Brian Apgar

  2. Detection of Newly Deposited Sediments Via Frequency Response Measurements: Dredging Residuals Density Profiler (DRDP)

    EPA Science Inventory

    The laboratory evaluation of the DRDP summarized in this report was conducted for the U.S. Environmental Protection Agency (EPA). Dr. Brian Schumacher of the EPA’s Environmental Sciences Division (ESD) of the Office of Research and Development’s National Exposure Research Laborat...

  3. NIF featured on BBC "Horizon"

    ScienceCinema

    Brian Cox

    2017-12-09

    The National Ignition Facility, the world's largest laser system, located at Lawrence Livermore National Laboratory, was featured in the BBC broadcast "Horizon" hosted by physicist Brian Cox. Here is the NIF portion of the program, which was entitled "Can We Make A Star On Earth?" This video is used with the express permission of the BBC.

  4. NIF featured on BBC "Horizon"

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brian Cox

    2010-01-12

    The National Ignition Facility, the world's largest laser system, located at Lawrence Livermore National Laboratory, was featured in the BBC broadcast "Horizon" hosted by physicist Brian Cox. Here is the NIF portion of the program, which was entitled "Can We Make A Star On Earth?" This video is used with the express permission of the BBC.

  5. ESO 50th Anniversary Gala Dinner

    NASA Astrophysics Data System (ADS)

    Sirey, R.

    2012-12-01

    To formally mark the 50th anniversary of the signing of the ESO Convention, a gala dinner was held in the Munich Residenz. A brief report of the event is presented and the speeches are reproduced. The speakers were the President of the Council, Xavier Barcons; the German Minister for Education and Research, Prof. Dr Annette Schavan; the Bavarian State Minister for Science, Research and the Arts, Dr Wolfgang Heubisch; physics Nobel Laureate, Brian Schmidt; the current Director General, Tim de Zeeuw and the Chilean Minister of Foreign Affairs, Alfredo Moreno Charme.

  6. 75 FR 78212 - Proposed Information Collection; Comment Request; Center for Economic Studies Research Proposal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-15

    ... Economic Studies Research Proposal Process and Project Management AGENCY: U.S. Census Bureau, Commerce... Project Management System by visiting the CES Web site ( http://www.ces.census.gov/index/php ) and click...) and instructions should be directed to Dr. Brian P. Holly, Project Review Coordinator, Center for...

  7. X-ray Variability Constraints on Compton Cloud Models of Cygnus X-1

    NASA Technical Reports Server (NTRS)

    Vaughan, Brian

    1999-01-01

    We have now completed this work, and all related publications have either appeared in print or are currently in press. A list of these publications is given below. There have been essentially three works that have arisen from this proposal. Spectral analysis of the data is presented in Dove et al. (1998a). Timing analysis is presented in Nowak et al. (1999a). Theoretical implications of the data analysis are discussed in Nowak et al. (1999b). Preliminary versions of all these works were presented at various conferences, and are reported in Nowak et al. (1997, 1998), Wilms et al. (1997), and Dove et al. (1998b). The grant was predominantly used for salary support for Dr. Michael Nowak, Dr. James Dove, and Dr. J. Wilms during the course of these projects. Grant funds were also used for Dr. Nowak to travel to Caltech to perform data analysis with Dr. Brian Vaughan, and for Dr. Wilms to visit JILA, University of Colorado, where much of this work was performed.

  8. Increased Cyclooxygenase-2-Derived Prostanoids Contributes to the Hyperreactivity to Noradrenaline in Mesenteric Resistance Arteries from Offspring of Diabetic Rats

    PubMed Central

    Santos-Rocha, Juliana; Duarte, Gloria P.; Xavier, Fabiano E.

    2012-01-01

    This study analyzed the effect of in utero exposure to maternal diabetes on contraction to noradrenaline in mesenteric resistance arteries (MRA) from adult offspring, focusing on the role of cyclooxygenase (COX)-derived prostanoids. Diabetes in the maternal rat was induced by a single injection of streptozotocin (50 mg/kg body weight) on day 7 of pregnancy. Contraction to noradrenaline was analyzed in isolated MRA from offspring of diabetic (O-DR) and non-diabetic (O-CR) rats at 3, 6 and 12 months of age. Release of thromboxane A2 (TxA2) and prostaglandins E2 (PGE2) and F2α (PGF2α), was measured by specific enzyme immunoassay kits. O-DR developed hypertension from 6 months of age compared with O-CR. Arteries from O-DR were hyperactive to noradrenaline only at 6 and 12 months of age. Endothelial removal abolished this hyperreactivity to noradrenaline between O-CR and O-DR. Preincubation with either the COX-1/2 (indomethacin) or COX-2 inhibitor (NS-398) decreased noradrenaline contraction only in 6- and 12-month-old O-DR, while it remained unmodified by COX-1 inhibitor SC-560. In vessels from 6-month-old O-DR, a similar reduction in the contraction to noradrenaline produced by NS-398 was observed when TP and EP receptors were blocked (SQ29548+AH6809). In 12-month-old O-DR, this effect was only achieved when TP, EP and FP were blocked (SQ29548+AH6809+AL8810). Noradrenaline-stimulated TxB2 and PGE2 release was higher in 6- and 12-month-old O-DR, whereas PGF2α was increased only in 12-month-old O-DR. Our results demonstrated that in utero exposure to maternal hyperglycaemia in rats increases the participation of COX-2-derived prostanoids on contraction to noradrenaline, which might help to explain the greater response to this agonist in MRA from 6- and 12-month-old offspring. As increased contractile response in resistance vessels may contribute to hypertension, our results suggest a role for these COX-2-derived prostanoids in elevating vascular resistance and blood pressure in offspring of diabetic rats. PMID:23209788

  9. House Committee on Science, Space, and Technology Hearing

    NASA Image and Video Library

    2018-05-17

    NASA Associate Administrator for the Human Exploration and Operations Mission Directorate William Gerstenmaier, left, Dr. Bhavya Lal, a researcher at the Institute for Defense Analysis's Science and Technology Policy Institute, center, and Dr. Elizabeth Cantwell, chief executive officer at the Arizona State University Research Enterprise, right, listen as Rep. Brian Babin, R-Texas, is seen on screen as he delivers an opening statement during a House Committee on Science, Space, and Technology hearing titled "America's Human Presence in Low-Earth Orbit" on Thursday, May 17, 2018 in the Rayburn House Office Building in Washington. Photo Credit: (NASA/Joel Kowsky)

  10. Dividing Our Enemies

    DTIC Science & Technology

    2005-11-01

    Hashem President Dr. Brian A. Maher Vice President Strategic Studies Department Lieutenant Colonel Michael C. McMahon Director James D . Anderson... Internet messages and held face-to-face brief- ings with tribal, political and religious leaders. After U.S. and Iraqi forces retook Fallujah, the Joint...Eric Micheletti, Special Forces: War on Terrorism in Afghanistan, 2001- 2003 (Paris: Histoire & Collections, 2004), pages 6-12. 10. David Pugliese

  11. Disabilities from an Insider's Perspective

    ERIC Educational Resources Information Center

    Naughton, Jacqueline

    2011-01-01

    Brian Schorr is an adult with ADHD. Dr. Gabrielle D'Amato, Ph.D., first diagnosed him with ADHD in 2003 when he was living in Ronkonkoma, New York. His main reason for seeking professional help at that time was that he was unable to understand why he had so many piles of papers in his office, why he kept forgetting things, and why he hated a part…

  12. Uniformed Services University of the Health Sciences. 2008 Report

    DTIC Science & Technology

    2008-01-01

    Maryland. 72008 Report HJF Fellowships Three promising USU doctoral students were selected by the Henry M . Jackson Foundation for the Advancement of...program, was chosen pharmacology department chairman, succeeding Brian Cox, Ph.D., who stepped down after 17 years. Mary Lou Cutler, Ph.D., a...spent Father’s Day backstage at Nissan Pavilion in Bristow, Virginia, as volunteers for the Tug McGraw Foundation and guests of Grammy- winning

  13. Regulation of Intracellular Free Calcium in Neuronal Cells by Opioids

    DTIC Science & Technology

    1995-06-19

    APPROVAL SHEET Title of Dissertation: "Regulation ofIntracellular Free Calcium in Neuronal Cells by Opioids" Name of Candidate: Tianlai Tang Doctor...Calcium in Neuronal Cells by Opioids" beyond brief excerpts is with the pennission of the copyright owner, and will save and hold harmless the...Intracellular Free Calcium in Neuronal Cells by Opioids Doctor of Philosophy, 1995 Brian M. Cox, Professor, Department of Pharmacology The

  14. News Education: Physics Education Networks meeting has global scale Competition: Competition seeks the next Brian Cox Experiment: New measurement of neutrino time-of-flight consistent with the speed of light Event: A day for all those who teach physics Conference: Students attend first Anglo-Japanese international science conference Celebration: Will 2015 be the 'Year of Light'? Teachers: Challenging our intuition in spectacular fashion: the fascinating world of quantum physics awaits Research: Science sharpens up sport Learning: Kittinger and Baumgartner: on a mission to the edge of space International: London International Youth Science Forum calls for leading young scientists Competition: Physics paralympian challenge needs inquisitive, analytical, artistic and eloquent pupils Forthcoming events

    NASA Astrophysics Data System (ADS)

    2012-05-01

    Education: Physics Education Networks meeting has global scale Competition: Competition seeks the next Brian Cox Experiment: New measurement of neutrino time-of-flight consistent with the speed of light Event: A day for all those who teach physics Conference: Students attend first Anglo-Japanese international science conference Celebration: Will 2015 be the 'Year of Light'? Teachers: Challenging our intuition in spectacular fashion: the fascinating world of quantum physics awaits Research: Science sharpens up sport Learning: Kittinger and Baumgartner: on a mission to the edge of space International: London International Youth Science Forum calls for leading young scientists Competition: Physics paralympian challenge needs inquisitive, analytical, artistic and eloquent pupils Forthcoming events

  15. New Research Methods Developed for Studying Diabetic Foot Ulceration

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Dr. Brian Davis, one of the Cleveland Clinic Foundation's researchers, has been investigating the risk factors related to diabetic foot ulceration, a problem that accounts for 20 percent of all hospital admissions for diabetic patients. He had developed a sensor pad to measure the friction and pressure forces under a person's foot when walking. As part of NASA Lewis Research Center's Space Act Agreement with the Cleveland Clinic Foundation, Dr. Davis requested Lewis' assistance in visualizing the data from the sensor pad. As a result, Lewis' Interactive Data Display System (IDDS) was installed at the Cleveland Clinic. This computer graphics program is normally used to visualize the flow of air through aircraft turbine engines, producing color two- and three-dimensional images.

  16. Non-Magnetic On-Chip Resonant Acousto-Optic Isolator at 780 nm

    DTIC Science & Technology

    2017-08-04

    SPONSOR/MONITOR’S ACRONYM(S) Air Force Research Laboratory Space Vehicles Directorate 3550 Aberdeen Avenue SE Kirtland AFB, NM 87117-5776 AFRL /RVBYE 11...Belvoir, VA 22060-6218 AFRL /RVIL Kirtland AFB, NM 87117-5776 Official Record Copy AFRL /RVBYE/Dr. Brian Kasch 1 cy Approved for public release... AFRL -RV-PS- AFRL -RV-PS- TR-2017-0170 TR-2017-0170 NON-MAGNETIC ON-CHIP RESONANT ACOUSTO- OPTIC ISOLATOR AT 780 nm Gaurav Bahl University of

  17. Symmetrized Nearest Neighbor Regression Estimates.

    DTIC Science & Technology

    1987-12-01

    TELEPHONE NUMBER 22C. OFFICE SYMBO0L (Inetude A me. Code) Major Brian Woodruff 1(202) 767-5026 1 Dr -’ 00 PORN 147,303- APR EDI1TION OF I JAN 73 IS...in tenth of a pence) in 1973. The data come from the Family Ex- penditure Survey, Annual Base Tapes 1968-198S, Department of Employment, Statistics...Statistics, 13, 1465- 1481. Hildenbrand, K. and Hildenbrand, W. (1986). On the mean income effect: a data analysis of the U.K. family expenditure

  18. Big Bang Day : Physics Rocks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2009-10-07

    Is particle physics the new rock 'n' roll? The fundamental questions about the nature of the universe that particle physics hopes to answer have attracted the attention of some very high profile and unusual fans. Alan Alda, Ben Miller, Eddie Izzard, Dara O'Briain and John Barrowman all have interests in this branch of physics. Brian Cox - CERN physicist, and former member of 90's band D:Ream, tracks down some very well known celebrity enthusiasts and takes a light-hearted look at why this subject can appeal to all of us.

  19. Big Bang Day : Physics Rocks

    ScienceCinema

    None

    2017-12-09

    Is particle physics the new rock 'n' roll? The fundamental questions about the nature of the universe that particle physics hopes to answer have attracted the attention of some very high profile and unusual fans. Alan Alda, Ben Miller, Eddie Izzard, Dara O'Briain and John Barrowman all have interests in this branch of physics. Brian Cox - CERN physicist, and former member of 90's band D:Ream, tracks down some very well known celebrity enthusiasts and takes a light-hearted look at why this subject can appeal to all of us.

  20. 2K09 and thereafter : the coming era of integrative bioinformatics, systems biology and intelligent computing for functional genomics and personalized medicine research.

    PubMed

    Yang, Jack Y; Niemierko, Andrzej; Bajcsy, Ruzena; Xu, Dong; Athey, Brian D; Zhang, Aidong; Ersoy, Okan K; Li, Guo-Zheng; Borodovsky, Mark; Zhang, Joe C; Arabnia, Hamid R; Deng, Youping; Dunker, A Keith; Liu, Yunlong; Ghafoor, Arif

    2010-12-01

    Significant interest exists in establishing synergistic research in bioinformatics, systems biology and intelligent computing. Supported by the United States National Science Foundation (NSF), International Society of Intelligent Biological Medicine (http://www.ISIBM.org), International Journal of Computational Biology and Drug Design (IJCBDD) and International Journal of Functional Informatics and Personalized Medicine, the ISIBM International Joint Conferences on Bioinformatics, Systems Biology and Intelligent Computing (ISIBM IJCBS 2009) attracted more than 300 papers and 400 researchers and medical doctors world-wide. It was the only inter/multidisciplinary conference aimed to promote synergistic research and education in bioinformatics, systems biology and intelligent computing. The conference committee was very grateful for the valuable advice and suggestions from honorary chairs, steering committee members and scientific leaders including Dr. Michael S. Waterman (USC, Member of United States National Academy of Sciences), Dr. Chih-Ming Ho (UCLA, Member of United States National Academy of Engineering and Academician of Academia Sinica), Dr. Wing H. Wong (Stanford, Member of United States National Academy of Sciences), Dr. Ruzena Bajcsy (UC Berkeley, Member of United States National Academy of Engineering and Member of United States Institute of Medicine of the National Academies), Dr. Mary Qu Yang (United States National Institutes of Health and Oak Ridge, DOE), Dr. Andrzej Niemierko (Harvard), Dr. A. Keith Dunker (Indiana), Dr. Brian D. Athey (Michigan), Dr. Weida Tong (FDA, United States Department of Health and Human Services), Dr. Cathy H. Wu (Georgetown), Dr. Dong Xu (Missouri), Drs. Arif Ghafoor and Okan K Ersoy (Purdue), Dr. Mark Borodovsky (Georgia Tech, President of ISIBM), Dr. Hamid R. Arabnia (UGA, Vice-President of ISIBM), and other scientific leaders. The committee presented the 2009 ISIBM Outstanding Achievement Awards to Dr. Joydeep Ghosh (UT Austin), Dr. Aidong Zhang (Buffalo) and Dr. Zhi-Hua Zhou (Nanjing) for their significant contributions to the field of intelligent biological medicine.

  1. 2K09 and thereafter : the coming era of integrative bioinformatics, systems biology and intelligent computing for functional genomics and personalized medicine research

    PubMed Central

    2010-01-01

    Significant interest exists in establishing synergistic research in bioinformatics, systems biology and intelligent computing. Supported by the United States National Science Foundation (NSF), International Society of Intelligent Biological Medicine (http://www.ISIBM.org), International Journal of Computational Biology and Drug Design (IJCBDD) and International Journal of Functional Informatics and Personalized Medicine, the ISIBM International Joint Conferences on Bioinformatics, Systems Biology and Intelligent Computing (ISIBM IJCBS 2009) attracted more than 300 papers and 400 researchers and medical doctors world-wide. It was the only inter/multidisciplinary conference aimed to promote synergistic research and education in bioinformatics, systems biology and intelligent computing. The conference committee was very grateful for the valuable advice and suggestions from honorary chairs, steering committee members and scientific leaders including Dr. Michael S. Waterman (USC, Member of United States National Academy of Sciences), Dr. Chih-Ming Ho (UCLA, Member of United States National Academy of Engineering and Academician of Academia Sinica), Dr. Wing H. Wong (Stanford, Member of United States National Academy of Sciences), Dr. Ruzena Bajcsy (UC Berkeley, Member of United States National Academy of Engineering and Member of United States Institute of Medicine of the National Academies), Dr. Mary Qu Yang (United States National Institutes of Health and Oak Ridge, DOE), Dr. Andrzej Niemierko (Harvard), Dr. A. Keith Dunker (Indiana), Dr. Brian D. Athey (Michigan), Dr. Weida Tong (FDA, United States Department of Health and Human Services), Dr. Cathy H. Wu (Georgetown), Dr. Dong Xu (Missouri), Drs. Arif Ghafoor and Okan K Ersoy (Purdue), Dr. Mark Borodovsky (Georgia Tech, President of ISIBM), Dr. Hamid R. Arabnia (UGA, Vice-President of ISIBM), and other scientific leaders. The committee presented the 2009 ISIBM Outstanding Achievement Awards to Dr. Joydeep Ghosh (UT Austin), Dr. Aidong Zhang (Buffalo) and Dr. Zhi-Hua Zhou (Nanjing) for their significant contributions to the field of intelligent biological medicine. PMID:21143775

  2. Defense Science Board 2003 Summer Study on DoD Roles and Missions in Homeland Security. Volume 1

    DTIC Science & Technology

    2003-11-01

    were used to develop a web-based "deployment picture." (A little money -a few million dollars-can go a long way in the combatant commands). OSD critical...AND MISSIONS f1 HOMELAND SECURJTY 91 APP8VD&XH Dr. Mark Harper U.S. Naval Academy Mr. Art Money Private Consultant Mr. Walter Morrow, Jr. MIT Lincoln...Protection BrigGen Irv Halter Discussion Mr. John Lauder Overview of NRO support to Homeland Security Mr. Brian Hack and Mr. Alan NRO Comms - NRO backbone

  3. ARC-2007-ACD07-0056-077

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/ shown here are Dr Chris McKay and Monika Kress, Professor of Astronomy at San Jose State University

  4. ARC-2007-ACD07-0056-072

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/ shown here are Dr Chris McKay and Monika Kress, Professor of Astronomy at San Jose State University

  5. ARC-2007-ACD07-0056-073

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/ shown here are Dr Chris McKay and Monika Kress, Professor of Astronomy at San Jose State University

  6. Ethnic Affirmation versus Social Desirability as a Determinant of Discrepancies in the Responses of Hispanic Bilinguals to Spanish and English Versions of a Questionnaire.

    DTIC Science & Technology

    1982-08-01

    and/or Dist Special Unclassified SEUIYCLASSIFPICATION OF THIS PAGE (When Data Nat efeQ REPORT DOCUMENTATION PAGE uu"o CO CMINOF 1. REPORT NUMINER...1) versus expected (7) 5.3 5.8 -2.99 .004 You feel that is undesirable (1) versus desirable (7) 5.1 5.7 -2.13 .038 You are talking with your co ...McPherson, GA 30330 Dr. Brian Usilaner GAO Army Research Institute Washington, DC 20548 Field Unit - Leavenworth P.O. Box 3122 Nat’l Institute of

  7. Remembering John M. Olson (1929-2017).

    PubMed

    Blankenship, Robert E; Brune, Daniel C; Olson, Jon C

    2018-02-19

    Here we provide reflections of and a tribute to John M. Olson, a pioneering researcher in photosynthesis. We trace his career, which began at Wesleyan University and the University of Pennsylvania, and continued at Utrech in The Netherlands, Brookhaven National Laboratory, and Odense University in Denmark. He was the world expert on pigment organization in the green photosynthetic bacteria, and discovered and characterized the first chlorophyll-containing protein, which has come to be known as the Fenna-Matthews-Olson (FMO) protein. He also thought and wrote extensively on the origin and early evolution of photosynthesis. We include personal comments from Brian Matthews, Raymond Cox, Paolo Gerola, Beverly Pierson and Jon Olson.

  8. Genomics, molecular imaging, bioinformatics, and bio-nano-info integration are synergistic components of translational medicine and personalized healthcare research.

    PubMed

    Yang, Jack Y; Yang, Mary Qu; Arabnia, Hamid R; Deng, Youping

    2008-09-16

    Supported by National Science Foundation (NSF), International Society of Intelligent Biological Medicine (ISIBM), International Journal of Computational Biology and Drug Design and International Journal of Functional Informatics and Personalized Medicine, IEEE 7th Bioinformatics and Bioengineering attracted more than 600 papers and 500 researchers and medical doctors. It was the only synergistic inter/multidisciplinary IEEE conference with 24 Keynote Lectures, 7 Tutorials, 5 Cutting-Edge Research Workshops and 32 Scientific Sessions including 11 Special Research Interest Sessions that were designed dynamically at Harvard in response to the current research trends and advances. The committee was very grateful for the IEEE Plenary Keynote Lectures given by: Dr. A. Keith Dunker (Indiana), Dr. Jun Liu (Harvard), Dr. Brian Athey (Michigan), Dr. Mark Borodovsky (Georgia Tech and President of ISIBM), Dr. Hamid Arabnia (Georgia and Vice-President of ISIBM), Dr. Ruzena Bajcsy (Berkeley and Member of United States National Academy of Engineering and Member of United States Institute of Medicine of the National Academies), Dr. Mary Yang (United States National Institutes of Health and Oak Ridge, DOE), Dr. Chih-Ming Ho (UCLA and Member of United States National Academy of Engineering and Academician of Academia Sinica), Dr. Andy Baxevanis (United States National Institutes of Health), Dr. Arif Ghafoor (Purdue), Dr. John Quackenbush (Harvard), Dr. Eric Jakobsson (UIUC), Dr. Vladimir Uversky (Indiana), Dr. Laura Elnitski (United States National Institutes of Health) and other world-class scientific leaders. The Harvard meeting was a large academic event 100% full-sponsored by IEEE financially and academically. After a rigorous peer-review process, the committee selected 27 high-quality research papers from 600 submissions. The committee is grateful for contributions from keynote speakers Dr. Russ Altman (IEEE BIBM conference keynote lecturer on combining simulation and machine learning to recognize function in 4D), Dr. Mary Qu Yang (IEEE BIBM workshop keynote lecturer on new initiatives of detecting microscopic disease using machine learning and molecular biology, http://ieeexplore.ieee.org/servlet/opac?punumber=4425386) and Dr. Jack Y. Yang (IEEE BIBM workshop keynote lecturer on data mining and knowledge discovery in translational medicine) from the first IEEE Computer Society BioInformatics and BioMedicine (IEEE BIBM) international conference and workshops, November 2-4, 2007, Silicon Valley, California, USA.

  9. Genomics, molecular imaging, bioinformatics, and bio-nano-info integration are synergistic components of translational medicine and personalized healthcare research

    PubMed Central

    2008-01-01

    Supported by National Science Foundation (NSF), International Society of Intelligent Biological Medicine (ISIBM), International Journal of Computational Biology and Drug Design and International Journal of Functional Informatics and Personalized Medicine, IEEE 7th Bioinformatics and Bioengineering attracted more than 600 papers and 500 researchers and medical doctors. It was the only synergistic inter/multidisciplinary IEEE conference with 24 Keynote Lectures, 7 Tutorials, 5 Cutting-Edge Research Workshops and 32 Scientific Sessions including 11 Special Research Interest Sessions that were designed dynamically at Harvard in response to the current research trends and advances. The committee was very grateful for the IEEE Plenary Keynote Lectures given by: Dr. A. Keith Dunker (Indiana), Dr. Jun Liu (Harvard), Dr. Brian Athey (Michigan), Dr. Mark Borodovsky (Georgia Tech and President of ISIBM), Dr. Hamid Arabnia (Georgia and Vice-President of ISIBM), Dr. Ruzena Bajcsy (Berkeley and Member of United States National Academy of Engineering and Member of United States Institute of Medicine of the National Academies), Dr. Mary Yang (United States National Institutes of Health and Oak Ridge, DOE), Dr. Chih-Ming Ho (UCLA and Member of United States National Academy of Engineering and Academician of Academia Sinica), Dr. Andy Baxevanis (United States National Institutes of Health), Dr. Arif Ghafoor (Purdue), Dr. John Quackenbush (Harvard), Dr. Eric Jakobsson (UIUC), Dr. Vladimir Uversky (Indiana), Dr. Laura Elnitski (United States National Institutes of Health) and other world-class scientific leaders. The Harvard meeting was a large academic event 100% full-sponsored by IEEE financially and academically. After a rigorous peer-review process, the committee selected 27 high-quality research papers from 600 submissions. The committee is grateful for contributions from keynote speakers Dr. Russ Altman (IEEE BIBM conference keynote lecturer on combining simulation and machine learning to recognize function in 4D), Dr. Mary Qu Yang (IEEE BIBM workshop keynote lecturer on new initiatives of detecting microscopic disease using machine learning and molecular biology, http://ieeexplore.ieee.org/servlet/opac?punumber=4425386) and Dr. Jack Y. Yang (IEEE BIBM workshop keynote lecturer on data mining and knowledge discovery in translational medicine) from the first IEEE Computer Society BioInformatics and BioMedicine (IEEE BIBM) international conference and workshops, November 2-4, 2007, Silicon Valley, California, USA. PMID:18831773

  10. The Evolution of Stellar Dynamos; Survey for Low Mass Members of NGC2232; An X-Ray Survey of the Open Cluster CR140; Towards a Better Understanding of the Rotation-Activity Relation for Solar-Type Members of the Pleiades

    NASA Technical Reports Server (NTRS)

    Stauffer, John R.; Petre, Robert (Technical Monitor)

    2000-01-01

    This grant was originally awarded to Dr. Charles Prosser, who died tragically in a car accident in Tucson in 1998. We had hoped to finish the work Charles had started, which involved analysis of ROSAT data for three programs (observations of the clusters NGC2232, Crl4O and the Pleiades) and also analysis of optical data for each cluster in order to allow interpretation of the ROSAT observations. The Pleiades portion of the program was completed during the past year, and a paper published. We have obtained optical imaging of the other two clusters, and those data are being analyzed. Dr. Brian Patten intends to complete analysis of the ROSAT observations and to combine those data with the optical photometry, but progress on those efforts has been slow due to the press of other work (Dr. Patten is responsible for the pipeline processing of data from SWAS). We intend to publish those results as soon as we can, but it will now be completed without further support from this grant.

  11. Inhibitors for Androgen Receptor Activation Surfaces

    DTIC Science & Technology

    2008-09-01

    such as FKBP52 or HSP90 bind in vivo, and started a collaboration with Marc Cox at UT El Paso to test these possibilities. Our assays of mutated amino...will complete testing the compounds in full length AR constructs and publish the results. We have begun two collaborations, one with Marc Cox on...Prof. Marc Cox and Dr. Paul Rennie to identify proteins that bind to BF3 so that we may form crystals of the receptor with these proteins and learn more about function of the human androgen receptor.

  12. Brian Smith | NREL

    Science.gov Websites

    Smith Photo of Brian Smith Brian Smith Laboratory Program Manager II - Mechanical Engineering Brian.Smith@nrel.gov | 303-384-6911 Brian Smith is Partnership Manager for the NWTC and focuses on portfolio

  13. U.S. Navy Capstone Strategies and Concepts: Introduction, Background and Analyses

    DTIC Science & Technology

    2011-12-01

    Zumwalt  Jun 1974 ADM James Holloway  Jul 1978 ADM Thomas Hayward  Jun 1982 ADM James Watkins  Jul 1986 ADM Carlisle Trost  Jun 1990 ADM Frank...RDML Bill Center USN (Ret) • Dr. Eugene Cobble (CNA) • CAPT Bud Cole USN (Ret) • Mr. Tim Colton • Dr. Greg Cox (CNA) • Hon. Seth Cropsey • RDML

  14. Brian Bush | NREL

    Science.gov Websites

    W Bush Photo of Brian Bush Brian Bush Researcher VI-Systems Engineering Brian.Bush@nrel.gov | 303 -384-7472 Orcid ID http://orcid.org/0000-0003-2864-7028 Brian W Bush is a member of the Systems Modeling team within the Systems Modeling & Geospatial Data Science Group in the Strategic Energy

  15. Savannah River Ecology Laboratory. Annual technical progress report of ecological research

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, M.H.

    1996-07-31

    The Savannah River Ecology Laboratory (SREL) is a research unit of the University of Georgia (UGA). The overall mission of the Laboratory is to acquire and communicate knowledge of ecological processes and principles. SREL conducts basic and applied ecological research, as well as education and outreach programs, under a contract with the U.S. Department of Energy (DOE) at the Savannah River Site (SRS) near Aiken, South Carolina. Significant accomplishments were made during the past year in the areas of research, education and service. The Laboratory`s research mission was fulfilled with the publication of two books and 143 journal articles andmore » book chapters by faculty, technical and students, and visiting scientists. An additional three books and about 80 journal articles currently are in press. Faculty, technician and students presented 193 lectures, scientific presentations, and posters to colleges and universities, including minority institutions. Dr. J Vaun McArthur organized and conducted the Third Annual SREL Symposium on the Environment: New Concepts in Strewn Ecology: An Integrative Approach. Dr. Michael Newman conducted a 5-day course titled Quantitative Methods in Ecotoxicology, and Dr. Brian Teppen of The Advanced Analytical Center for Environmental Sciences (AACES) taught a 3-day short course titled Introduction to Molecular Modeling of Environmental Systems. Dr. I. Lehr Brisbin co-hosted a meeting of the Crocodile Special Interest Group. Dr. Rebecca Sharitz attended four symposia in Japan during May and June 1996 and conducted meetings of the Executive Committee and Board of the International Association for Ecology (ENTECOL).« less

  16. Novel Fatty Acid Lipoxygenases in the Development of Human and Murine Prostate Cancer

    DTIC Science & Technology

    2000-10-01

    expression of COX-2 mRNA in benign and malignant prostate samples by RNase protection assays in collaboration with Dr. Matthew Breyer at Vanderbilt. COX-2...Shappell,* William E. Boeglin,t prostate adenocarcinomas. (Am J Pathol 1999, Sandy J. Olson,* Susan Kasper,f and 155:235-245) Alan R. Brasht From the...possible role of this novel enzyme in secretory function, 33157-331605. Samuelssor,- B. Dahlen SE, Lindgren JA, Rouzer CA, Serhan CN: Reduced expression in

  17. ERK1/2/COX-2/PGE2 signaling pathway mediates GPR91-dependent VEGF release in streptozotocin-induced diabetes

    PubMed Central

    Li, Tingting; Hu, Jianyan; Du, Shanshan; Chen, Yongdong; Wang, Shuai

    2014-01-01

    Purpose Retinal vascular dysfunction caused by vascular endothelial growth factor (VEGF) is the major pathological change that occurs in diabetic retinopathy (DR). It has recently been demonstrated that G protein-coupled receptor 91 (GPR91) plays a major role in both vasculature development and retinal angiogenesis. In this study, we examined the signaling pathways involved in GPR91-dependent VEGF release during the early stages of retinal vascular change in streptozotocin-induced diabetes. Methods Diabetic rats were assigned randomly to receive intravitreal injections of shRNA lentiviral particles targeting GPR91 (LV.shGPR91) or control particles (LV.shScrambled). Accumulation of succinate was assessed by gas chromatography-mass spectrometry (GC-MS). At 14 weeks, the ultrastructure and function of the retinal vessels of diabetic retinas with or without shRNA treatment were assessed using hematoxylin and eosin (HE) staining, transmission electron microscopy (TEM), and Evans blue dye permeability. The expression of GPR91, extracellular signal-regulated kinases 1 and 2 (ERK1/2) and cyclooxygenase-2 (COX-2) were measured using immunofluorescence and western blotting. COX-2 and VEGF mRNA were determined by quantitative RT–PCR. Prostaglandin E2 (PGE2) and VEGF secretion were detected using an enzyme-linked immunosorbent assay. Results Succinate exhibited abundant accumulation in diabetic rat retinas. The retinal telangiectatic vessels, basement membrane thickness, and Evans blue dye permeability were attenuated by treatment with GPR91 shRNA. In diabetic rats, knockdown of GPR91 inhibited the activities of ERK1/2 and COX-2 as well as the expression of PGE2 and VEGF. Meanwhile, COX-2, PGE2, and VEGF expression was inhibited by ERK1/2 inhibitor U0126 and COX-2 inhibitor NS-398. Conclusions Our data suggest that hyperglycemia causes succinate accumulation and GPR91 activity in retinal ganglion cells, which mediate VEGF-induced retinal vascular change via the ERK1/2/COX-2/PGE2 pathway. This study highlights the signaling pathway as a potential target for intervention in DR. PMID:25324681

  18. ARC-2007-ACD07-0056-035

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  19. ARC-2007-ACD07-0056-031

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  20. ARC-2007-ACD07-0056-067

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  1. ARC-2007-ACD07-0056-065

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  2. ARC-2007-ACD07-0056-050

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  3. ARC-2007-ACD07-0056-071

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  4. ARC-2007-ACD07-0056-115

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  5. ARC-2007-ACD07-0056-085

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  6. ARC-2007-ACD07-0056-119

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  7. ARC-2007-ACD07-0056-051

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  8. ARC-2007-ACD07-0056-058

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Desert , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  9. ARC-2007-ACD07-0056-136

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  10. ARC-2007-ACD07-0056-042

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  11. ARC-2007-ACD07-0056-027

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  12. ARC-2007-ACD07-0056-137

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  13. ARC-2007-ACD07-0056-135

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  14. ARC-2007-ACD07-0056-140

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  15. ARC-2007-ACD07-0056-075

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  16. ARC-2007-ACD07-0056-032

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  17. ARC-2007-ACD07-0056-117

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  18. ARC-2007-ACD07-0056-034

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  19. ARC-2007-ACD07-0056-043

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  20. ARC-2007-ACD07-0056-096

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  1. ARC-2007-ACD07-0056-063

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  2. ARC-2007-ACD07-0056-081

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  3. ARC-2007-ACD07-0056-024

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  4. ARC-2007-ACD07-0056-023

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Desert , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  5. ARC-2007-ACD07-0056-108

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  6. ARC-2007-ACD07-0056-132

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  7. ARC-2007-ACD07-0056-044

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  8. ARC-2007-ACD07-0056-089

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  9. ARC-2007-ACD07-0056-138

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  10. ARC-2007-ACD07-0056-021

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  11. ARC-2007-ACD07-0056-041

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  12. ARC-2007-ACD07-0056-110

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  13. ARC-2007-ACD07-0056-109

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  14. ARC-2007-ACD07-0056-134

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  15. ARC-2007-ACD07-0056-102

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  16. ARC-2007-ACD07-0056-139

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  17. ARC-2007-ACD07-0056-028

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  18. ARC-2007-ACD07-0056-070

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  19. ARC-2007-ACD07-0056-133

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  20. ARC-2007-ACD07-0056-018

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  1. ARC-2007-ACD07-0056-020

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  2. ARC-2007-ACD07-0056-112

    NASA Image and Video Library

    2007-03-27

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  3. ARC-2007-ACD07-0056-054

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  4. ARC-2007-ACD07-0056-048

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  5. ARC-2007-ACD07-0056-080

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  6. ARC-2007-ACD07-0056-030

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/

  7. Proceedings of the First All-USGS Modeling Conference, November 14-17, 2005

    USGS Publications Warehouse

    Frondorf, Anne

    2007-01-01

    Preface: The First All-USGS Modeling Conference was held November 14-17, 2005, in Port Angeles, Washington. U.S. Geological Survey (USGS) participants at the conference came from USGS headquarters and all USGS regions and represented all four science disciplines-Biology, Geography, Geology, and Water. The conference centered on selected oral case study presentations and posters on current USGS scientific modeling capabilities and activities. Abstracts for these case study presentations and posters are presented here. On behalf of all the participants of the First All-USGS Modeling Conference, we appreciate the support of Dee Ann Nelson and the staff of the Olympic Park Institute in providing the conference facilities; Dr. Jerry Freilich and Dr. Brian Winter of the National Park Service, Olympic National Park, for organizing and leading the conference field trip; and Debra Becker and Amy Newman, USGS Western Fisheries Research Center, Seattle, Washington, and Tammy Hansel, USGS Geospatial Information Office, Reston, Virginia, for providing technical support for the conference. The organizing committee for the conference included Jenifer Bracewell, Jacoby Carter, Jeff Duda, Anne Frondorf, Linda Gundersen, Tom Gunther, Pat Jellison, Rama Kotra, George Leavesley, and Doug Muchoney.

  8. 7. O'BRIAN CANAL After its bifurcation with the DenverHudson Canal, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. O'BRIAN CANAL After its bifurcation with the Denver-Hudson Canal, flowing into Barr Lake through a protected eagle nesting area - O'Brian Canal, South Platte River Drainage Area Northest of Denver, Brighton, Adams County, CO

  9. Importance of holographic light in the emerging field of mind-body healing

    NASA Astrophysics Data System (ADS)

    Booth, Roberta

    2000-10-01

    Healing with color has been researched and documented worldwide for centuries. Every single part of the brain and every cell in the body is effected by light. Chinese and Russian scientists demonstrated that the acupuncture meridians transmit light. Dr. Peter Mandel, German chiropractic physician and acupuncturist, states that the acupuncture points are especially sensitive to electromagnetic waves within the spectrum of visible light and microwave energy, and all cells constantly emit and absorb small pockets of electromagnetic radiation or light, called biophotons. The harmony or disharmony of cells has been documented. Kirlian photography, to photography the aura was invented by Russians Semyon and Valentina Kirlian. Photo therapy and light research are being practiced worldwide. In the United States, Dr. Jacob Lieberman has written an influential book Light Medicine of the Future. In 1992 the first Light Years Ahead conference was held. (#5 1996) Dr. Brian Breiling and Dr. Lee Hartley brought together experts in the field to discuss the many potentials of light therapy. My present research in this area has focused on narrow band frequencies through the use of holography. Its therapeutic applications of color healing in this research are both critical and fundamental. My current work, The Chakras, seven reflection holograms on silver halide, relate to the wheels of light described in the earliest recorded Indian history. I will discus the chakras, this ancient metaphysical system under the new light of popular western metaphors and visionary art, how the chakras relate to the seven colors of the rainbow, the electromagnetic waves, and the connection to color holography in healing light therapy. I will be citing concurrent research in color healing, and the important areas of research that are necessary to have significant impact on future directions. Holography in the future will constitute a major frontier in discovery.

  10. The Origin of The Piz Terri-Lunschania zone (Central Alps, Switzerland)

    NASA Astrophysics Data System (ADS)

    Galster, Federico; Stockli, Daniel

    2017-04-01

    The Piz Terri-Lunschania zone (PTLZ) represents a band of metasedimentary rocks embedded in a crucial knot at the NE border of the Lepontine dome, at the intersection of the Gotthard, Lucomagno, Simano, Adula and Grava nappes. Its origin and its position in the tectonostratigraphy of the Central Alps are still not completely understood. A better understanding of this sedimentary zone and its tectonic position could shed lights on the Helvetic-Penninic connection and facilitate the disentanglement of the Lepontine dome tectonics. In this study we combine structural and stratigraphic observations with detrital zircon (DZ) and detrital rutile (DR) U-Pb geochronology as well as mineral trace element data from Permian, Triassic and Jurassic sandstones. We compare these data with those from adjacent tectonic units and coeval strata in other portions of the Alpine chain. Maximal depositional ages, abrupt changes in provenances and stratigraphic correlations based on new DZ and DR U-Pb and trace element data allow for a better understanding of the sedimentary evolution of the Terri basin and its palaeogeographic position along the northern margin of the Alpine Tethys. In particular the DZ U-Pb signatures, with its abundant 260-280 Ma zircons and the scarcity of 290-350 Ma zircons, corroborates an Ultra-Adula origin of the PTLZ as proposed by Galster et al (2010; 2012) based on stratigraphic arguments and reinforces the notion of a Briançonnais influence on the stratigraphic record of this complex zone, a fact that has important tectonic and Palaeogeographic implications. Galster F, Cavargna-Sani M, Epard J-L, Masson H (2012) New stratigraphic data from the Lower Penninic between the Adula nappe and the Gotthard massif and consequences for the tectonics and the paleogeography of the Central Alps. Tectonophysics 579:37-55. doi: 10.1016/j.tecto.2012.05.029 Galster F, Epard J-L, Masson H (2010) The Soja and Luzzone-Terri nappes: Discovery of a Briançonnais element below the front of the Adula nappe (NE Ticino, Central Alps). Bulletin de la Société Vaudoise des Sciences naturelles 92:61-75.

  11. 76 FR 7836 - Rich, Brian R.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6467-000] Rich, Brian R.; Notice of Filing Take notice that on December 31, 2010, Brian R. Rich submitted for filing, an application for authority to hold interlocking positions, pursuant to part 45 of Title 18 of the Code of...

  12. Brian: a simulator for spiking neural networks in python.

    PubMed

    Goodman, Dan; Brette, Romain

    2008-01-01

    "Brian" is a new simulator for spiking neural networks, written in Python (http://brian. di.ens.fr). It is an intuitive and highly flexible tool for rapidly developing new models, especially networks of single-compartment neurons. In addition to using standard types of neuron models, users can define models by writing arbitrary differential equations in ordinary mathematical notation. Python scientific libraries can also be used for defining models and analysing data. Vectorisation techniques allow efficient simulations despite the overheads of an interpreted language. Brian will be especially valuable for working on non-standard neuron models not easily covered by existing software, and as an alternative to using Matlab or C for simulations. With its easy and intuitive syntax, Brian is also very well suited for teaching computational neuroscience.

  13. "Different is nice, but it sure isn't easy": differentiating the spectrum of autism from the spectrum of normalcy.

    PubMed

    Costello, Eileen; Blenner, Stephanie; Augustyn, Marilyn

    2010-01-01

    Brian is a 15-year-old boy who has been just changed to your practice because of a change in insurance plans. When taking the social history, his parents note that he has "the hardest time relating to other kids." Sometimes he will be in the middle of a conversation with a friend and then discuss tangential topics. His father reports that Brian "...has always been an easy target. He has always been sort of bigger than other kids, but being bigger than other kids, he has a hard time standing up for himself." He seems to expect to be picked on in any new social situation. When Brian likes something, he really goes after it with a passion; for example, he is very interested in knowing all about the dynasties in China. His interests are dinosaurs and anime. He is described as "An all-or-nothing type kid" when it comes to his interests. If his father tries to explain to Brian why he would like something done in a particular way, Brian will explode, and at times, he has even tried to shove his father. He does not really have any friends. His mother finds it hard knowing that Brian cannot make friends because he "is the sweetest kid you will ever meet." Brian sometimes thinks he needs to master things right away. He is not very good at abstract thinking, and "he can't think outside of the box." Eye contact has always been something that has been difficult for Brian as well. He can sit in front of the TV watching a show and repeat the entire series word for word. His parents initially had concerns about Brian, when he was 3 or 4 years old. After a specialty evaluation, he was diagnosed with sensory integration disorder and attention-deficit hyperactivity disorder. He is currently starting the 10th grade this year. Brian was born at 9 months, weighing 7 pounds 10 ounces. There were no complications. He was treated with stimulants for attention-deficit hyperactivity disorder in the past, and he is currently on a long-acting amphetamine with equivocal efficacy. The parents are primarily here to refill his medication, but you wonder about their understanding about Brian's condition and where to head next during this visit.

  14. STS-72 Liftoff viewed from left side of Pad 39B

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The Space Shuttle Endeavour lights up the night sky as it thunders aloft from Launch Pad 39B. Liftoff of Mission STS- 72 occurred at 4:41:00.072 am EST, January 11, kicking off the 1996 Shuttle launch schedule. On board Endeavour are a crew of six: Commander Brian Duffy; Pilot Brent W. Jett; and Mission Specialists Dr. Daniel T. Barry, Leroy Chiao, Winston E. Scott, and Koichi Wakata, who represents the National Space Development Agency (NASDA) of Japan. During their planned nine-day mission, the crew will retrieve the Japanese Space Flyer Unit (SFU), deploy and later retrieve the Office of Aeronautics and Space Technology-Flyer (OAST- Flyer), and conduct two extravehicular activities (EVAs). STS-72 is the 74th Shuttle mission and the 10th flight of the orbiter Endeavour.

  15. ARC-2007-ACD07-0056-064

    NASA Image and Video Library

    2007-03-26

    Spaceward Bound event in the Mojave Deser , CA (an outreach exercise) with Dr Chris McKay and Ames Education department personnel Brian Day, Barbara Bazar and a accompaning (learning for the the classroom) team of teachers will be studying side-by-side with NASA scientists who search for life in extreme environments, closely approximating what they expect to find on other planets. Why the Mojave -- an inhospitable, sun-drenched spot in the California Desert? This natural setting presents scientists with opportunities to study environments that are analogous to what explorers will find on the Moon and Mars. Teachers and scientists will perform scientific fieldwork in lunar geology, Mars astrobiology, Mars geology, and issues of temperature and solar inundation and radiation. for additional information and Outreach projects see http://quest.arc.nasa.gov/ shown here: Monika Kress, Professor of Astronomy at San Jose State University

  16. 75 FR 36060 - Notice of Request for Extension of Approval of an Information Collection; Blood and Tissue...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-24

    ... Paperwork Reduction Act of 1995, this notice announces the Animal and Plant Health Inspection Service's... establishments, contact Dr. Debra Cox, Senior Staff Veterinarian, Surveillance and Identification Programs, NCAHP... information collection. Abstract: Under the Animal Health Protection Act (7 U.S.C. 8301 et seq.), the Animal...

  17. The discovery of Caligus temnodontis Brian, 1924 (Copepoda: Caligidae) from the bluefish Pomatomus saltatrix (Linnaeus) in the eastern Mediterranean Sea.

    PubMed

    Ozak, Argun A; El-Rashidy, Hoda H; Demirkale, Ibrahim; Boxshall, Geoff A

    2010-07-01

    The temnodontis variety of Caligus mauritanicus Brian, 1924 described by Brian (1924) is a valid species known only from a single host species, Pomatomus saltatrix (Linnaeus). New material of this species has been examined from the same host fish caught from Abuqir Bay, Alexandria (Egypt), from Iskenderun Bay (Turkey) and from off the coast of South Africa. Using this material, C. temnodontis Brian, 1924 is redescribed and compared with related species. It is most closely related to the Indo-Pacific species C. pagrosomi Yamaguti, 1939.

  18. Neglected Women Historians: The Case of Joan Simon

    ERIC Educational Resources Information Center

    Martin, Jane

    2014-01-01

    Joan Simon (née Peel, 1915-2005) was the life-long partner of Brian Simon who helped launch FORUM in September 1958. Like Brian, she embraced a Communist outlook and engagement in the area of education. Unlike Brian, she practiced the historian's craft outside the male academic hierarchy. Based on newly available personal papers this study…

  19. The contribution of major diagnostic causes to socioeconomic differences in disability retirement.

    PubMed

    Polvinen, Anu; Laaksonen, Mikko; Gould, Raija; Lahelma, Eero; Martikainen, Pekka

    2014-07-01

    The aim of this study was twofold: to investigate socioeconomic differences in disability retirement (DR) due to major diseases and find out which diseases contribute most to the overall socioeconomic differences in DR. The data were longitudinal register-based (10% sample of Finns) from Statistics Finland. These data included 258 428 participants aged 35-64 years during the follow-up. The participants were employed or unemployed before the follow-up period 1997-2010. Of all participants, 14 303 men and 13 188 women ended up in DR during the follow-up. Socioeconomic status was categorized into upper- and lower-class non-manual employees, manual workers, and self-employed persons. Cox models were used to estimate hazard ratios for DR due to different diseases. Compared to upper-class non-manual employees, DR was especially high for manual workers whose retirement diagnoses included psychoactive substance use, musculoskeletal diseases (MSD), or cardiovascular diseases. Socioeconomic differences in DR were stronger for younger age groups and men versus women. For females and males, the largest part of the excess DR among manual workers compared to upper-class non-manual employees was due to MSD. In the age group 54-64 years, the contribution of MSD to the total excess was >50% among male manual workers and 75% among female manual workers. Excess DR due to mental disorders concerned only 35-54-year-old manual workers (among 23% men and 26% women). The contribution of MSD to the total excess DR among lower socioeconomic groups was large. Prevention of MSD among manual workers would likely reduce socioeconomic differences in DR.

  20. Brian Barry: innovative contributions to transdermal and topical drug delivery.

    PubMed

    Williams, A C

    2013-01-01

    Brian Barry published over 300 research articles across topics ranging from colloid science, vasoconstriction and the importance of thermodynamics in dermal drug delivery to exploring the structure and organisation of the stratum corneum barrier lipids and numerous strategies for improving topical and transdermal drug delivery, including penetration enhancers, supersaturation, coacervation, eutectic formation and the use of varied liposomes. As research in the area blossomed in the early 1980s, Brian wrote the book that became essential reading for both new and established dermal delivery scientists, explaining the background mathematics and principles through to formulation design. Brian also worked with numerous scientists, as collaborators and students, who have themselves taken his rigorous approach to scientific investigation into their own research groups. This paper can only describe a small fraction of the many significant contributions that Brian made to the field during his 40-year academic career.

  1. Simpler and equitable allocation of kidneys from postmortem donors primarily based on full HLA-DR compatibility.

    PubMed

    Doxiadis, Ilias I N; de Fijter, Johan W; Mallat, Marko J K; Haasnoot, Geert W; Ringers, Jan; Persijn, Guido G; Claas, Frans H J

    2007-05-15

    The introduction of human leukocyte antigen (HLA)-matching in nonliving kidney transplantation has resulted into a better graft outcome, but also in an increase of waiting time, especially for patients with rare HLA phenotypes. We addressed the question of the differential influence of HLA-DR-matching versus HLA-A,B in clinical kidney transplantation. We used Kaplan-Meier product limit method to estimate survival rates, and Cox proportional hazard regression for the estimation of relative risks (Hazard-ratios) for different variables. A single center study (n=456 transplants, performed between 1985 and 1999) showed that full HLA-DR compatibility leads to a lower incidence of biopsy confirmed acute rejections in the first 180 posttransplantation days. These results were substantiated using the Eurotransplant database (n=39,205 transplants performed between 1985 and 2005) where graft survival in the full HLA-DR compatible group was significantly better than in the incompatible. An additional positive effect of HLA-A,B matching was only found in the full HLA-DR compatible group. In both studies, the introduction of a single HLA-DR incompatibility eliminates the HLA-A,B matching effect. We propose to allocate postmortem kidneys only to patients with full HLA-DR compatibility, and use HLA-A,B compatibility as an additional selection criterion. All patients, irrespective of their ethnic origin, will profit since the polymorphism of HLA-DR is by far lower than that of HLA-A,B. Excessive kidney travel and cold ischemia time will be significantly reduced.

  2. Creation of Vapor/Gas Impermeable Coatings for CB Hardening of Existing Structures

    DTIC Science & Technology

    2013-04-05

    TEST REPORT for POLYMERight, Inc. Coating Agent Testing Prepared for: POLYMERight, Inc. Prepared by: Edward Soja Brian Blackstone ...POLYMERight, Inc. Mr. Alex Vainer 4404-C Enterprise Place Fremont, CA 94538 Prepared by: Edward Soja Brian Blackstone Battelle 505 King Ave...Inc. Coating Agent Testing 24 7.0 Contacts Contact Role Location Phone Brian Blackstone Program Manager Battelle, West Jefferson (614) 424

  3. Character Development of U.S. Army Leaders: A Laissez Faire Approach

    DTIC Science & Technology

    2013-03-01

    Character Development of U.S. Army Leaders: A Laissez Faire Approach by Colonel Brian M. Michelson United States Army...Army Leaders: A Laissez Faire Approach 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Colonel Brian M...STRATEGY RESEARCH PROJECT Character Development of U.S. Army Leaders: A Laissez Faire Approach by Colonel Brian M

  4. OPTIMIZATION OF MUD HAMMER DRILLING PERFORMANCE - A PROGRAM TO BENCHMARK THE VIABILITY OF ADVANCED MUD HAMMER DRILLING

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gordon Tibbitts; Arnis Judzis

    2002-07-01

    This document details the progress to date on the OPTIMIZATION OF MUD HAMMER DRILLING PERFORMANCE -- A PROGRAM TO BENCHMARK THE VIABILITY OF ADVANCED MUD HAMMER DRILLING contract for the quarter starting April 2002 through June 2002. Even though we are awaiting the optimization portion of the testing program, accomplishments include the following: (1) Presentation material was provided to the DOE/NETL project manager (Dr. John Rogers) for the DOE exhibit at the 2002 Offshore Technology Conference. (2) Two meeting at Smith International and one at Andergauge in Houston were held to investigate their interest in joining the Mud Hammer Performancemore » study. (3) SDS Digger Tools (Task 3 Benchmarking participant) apparently has not negotiated a commercial deal with Halliburton on the supply of fluid hammers to the oil and gas business. (4) TerraTek is awaiting progress by Novatek (a DOE contractor) on the redesign and development of their next hammer tool. Their delay will require an extension to TerraTek's contracted program. (5) Smith International has sufficient interest in the program to start engineering and chroming of collars for testing at TerraTek. (6) Shell's Brian Tarr has agreed to join the Industry Advisory Group for the DOE project. The addition of Brian Tarr is welcomed as he has numerous years of experience with the Novatek tool and was involved in the early tests in Europe while with Mobil Oil. (7) Conoco's field trial of the Smith fluid hammer for an application in Vietnam was organized and has contributed to the increased interest in their tool.« less

  5. Autonomic nervous system function assessed by conventional and spectral analysis might be useful in terms of predicting retinal deterioration in persons with type 1 diabetes mellitus.

    PubMed

    Duvnjak, L; Tomić, M; Blaslov, K; Vučković Rebrina, S

    2016-06-01

    To determine whether cardiac autonomic dysfunction represents a risk factor for diabetic retinopathy (DR) development and progression in persons with type 1 diabetes mellitus (T1DM). The study comprised 154 normoalbuminuric persons with T1DM divided into two groups according to the DR presence: with and without DR. Cardiovascular autonomic functioning was measured at baseline using conventional and spectral analysis. Participants were re-examined for the DR presence 18months after. The group with DR had longer disease duration compared to the group without DR (20 vrs 11.5years, p<0.001), heart rate coefficient of variation (HRV-CV) at rest and during deep breathing were lower in participants with DR (p=0.001 and 0.004), as well did spectral indices of HRV: low frequency (LF) band, high frequency (HF) band (p=0.003 and 0.022) while LF/HF ratio indicating sympathovagal balance was higher (p=0.037). No difference in glycaemic control or blood pressure value were observed. Twenty-one (13.36%) participants developed non proliferative DR or progressed to proliferative DR. Cox proportional regression showed that the 18months risk from retinal deterioration was reduced by 33.4% by each increase in the HRV-CV of 1%, 12.7% for the same HRV-CV increase during deep breathing while LF band of 1ms(2) results in 8.6% risk reduction. This study provides evidence that DR should not be considered merely a metabolic control manifestation and that HRV-CV as well as spectral indices of HRV might serve as a practical tool to identify a subgroup of T1DM patients with higher risk of retinal deterioration. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  6. Remaining Relevant: Historical Contributions, Civil-Military Challenges, and Anti-Submarine Warfare Capabilities on Coast Guard Cutters

    DTIC Science & Technology

    2018-03-01

    HISTORICAL CONTRIBUTIONS, CIVIL-MILITARY CHALLENGES, AND ANTI-SUBMARINE WARFARE CAPABILITIES ON COAST GUARD CUTTERS by Brian A. Smicklas...CONTRIBUTIONS, CIVIL- MILITARY CHALLENGES, AND ANTI-SUBMARINE WARFARE CAPABILITIES ON COAST GUARD CUTTERS 5. FUNDING NUMBERS 6. AUTHOR(S) Brian A...MILITARY CHALLENGES, AND ANTI-SUBMARINE WARFARE CAPABILITIES ON COAST GUARD CUTTERS Brian A. Smicklas Commander, U.S. Coast Guard B.S., Coast

  7. Aspirin in the Management of Patients with Prostate Cancer Undergoing Radiotherapy: Friend or Foe?

    PubMed

    Mascan, Bianca; Marignol, Laure

    2018-04-01

    Aspirin has cyclooxygenase-2 (COX2)-mediated anti-inflammatory and anti-coagulant properties that may confer a positive effect in preventing and limiting the progression of prostate cancer. Prostate cancer has been shown to have poor treatment outcomes due to therapeutic resistance; therefore, COX2 inhibition caused by aspirin could represent an opportunity to augment current therapies. This is particularly of interest to patients undergoing radiation therapy (RT) where inflammation is a common side-effect. This review discusses the evidence for the potential role of aspirin in the management of patients with prostate cancer undergoing RT. Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  8. American Tertiary mollusks of the genus Clementia

    USGS Publications Warehouse

    Woodring, W.P.

    1927-01-01

    Aside from its value as an aid in determining the age of Tertiary beds, the chief interest of the genus Clementia lies in the anomalous features of its present and former distribution. An attempt is made in this paper to trace its geologic history, to point out its paleobiologic significance, and to describe all the known American Tertiary species. The fossils from Colombia used in preparing this report were collected during explorations made under the direction of Dr. 0. B. Hopkins, chief geologist of the Imperial Oil Co. (Ltd.), who kindly donated them to the United States National Museum. Dr. T. Wayland Vaughan, of the Scripps Institution of Oceanography, furnished information relating to specimens collected by him in Mexico. Dr. Bruce L. Clark, of the University of California; Dr. G. Dallas Hanna, of the California Academy of Sciences; Dr. H. A. Pilsbry, of the Philadelphia Academy of Natural Sciences; and Dr. W. D. Matthew, of the American Museum of Natural History, generously loaned type specimens and other material. Doctor Clark and Doctor Hanna also gave information concerning the Tertiary species from California. Mr. Ralph B. Stewart, of the University of California, read the manuscript, and I have taken advantage of his suggestions. I am also indebted to Mr. L. R. Cox, of the British Museum, for information relating to the fossil species from Persia, Zanzibar, and Burma, and to Dr. Axel A. Olsson, of the International Petroleum Co., for data concerning undescribed Tertiary species from Peru.

  9. Survival analysis of cervical cancer using stratified Cox regression

    NASA Astrophysics Data System (ADS)

    Purnami, S. W.; Inayati, K. D.; Sari, N. W. Wulan; Chosuvivatwong, V.; Sriplung, H.

    2016-04-01

    Cervical cancer is one of the mostly widely cancer cause of the women death in the world including Indonesia. Most cervical cancer patients come to the hospital already in an advanced stadium. As a result, the treatment of cervical cancer becomes more difficult and even can increase the death's risk. One of parameter that can be used to assess successfully of treatment is the probability of survival. This study raises the issue of cervical cancer survival patients at Dr. Soetomo Hospital using stratified Cox regression based on six factors such as age, stadium, treatment initiation, companion disease, complication, and anemia. Stratified Cox model is used because there is one independent variable that does not satisfy the proportional hazards assumption that is stadium. The results of the stratified Cox model show that the complication variable is significant factor which influent survival probability of cervical cancer patient. The obtained hazard ratio is 7.35. It means that cervical cancer patient who has complication is at risk of dying 7.35 times greater than patient who did not has complication. While the adjusted survival curves showed that stadium IV had the lowest probability of survival.

  10. Thin Film Thermoelectric Metal-Organic Framework with High Seebeck Coefficient and Low Thermal Conductivity. Supporting Information

    DTIC Science & Technology

    2015-04-28

    François Léonard, Vitalie Stavila, Michael E. Foster, Catalin D. Spataru, Reese E. Jones, Brian M. Foley, Patrick E. Hopkins, Mark D. Allendorf, A. Alec...Léonard, Vitalie Stavila, Michael E. Foster, Catalin D. Spataru, Reese E. Jones, Brian M. Foley, Patrick E. Hopkins, Mark D. Allendorf, and A. Alec Talin...Kristopher J. Erickson, François Léonard, Vitalie Stavila, Michael E. Foster, Catalin D. Spataru, Reese E. Jones, Brian M. Foley, Patrick E. Hopkins, Mark D

  11. G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases.

    PubMed

    Hu, Jianyan; Li, Tingting; Du, Xinhua; Wu, Qiang; Le, Yun-Zheng

    2017-10-01

    G protein-coupled receptor 91 (GPR91) is a succinate-specific receptor and activation of GPR91 could initiate a complex signal transduction cascade and upregulate inflammatory and pro-angiogenic cytokines. In the retina, GPR91 is predominately expressed in ganglion cells, a major cellular entity involved in the pathogenesis of diabetic retinopathy (DR) and other hypoxic retinal diseases. During the development of DR and retinopathy of prematurity (ROP), chronic hypoxia causes an increase in the levels of local succinate. Succinate-mediated GPR91 activation upregulates vascular endothelial growth factor (VEGF) through ERK1/2-C/EBP β (c-Fos) and/or ERK1/2-COX-2/PGE2 signaling pathways, which in turn, leads to the breakdown of blood-retina barriers in these disorders. In this review, we will have a brief introduction of GPR91 and its biological functions and a more detailed discussion about the role and mechanisms of GPR91 in DR and ROP. A better understanding of GPR91 regulation may be of great significance in identifying new biomarkers and drug targets for the prediction and treatment of DR, ROP, and hypoxic retinal diseases. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. 76 FR 73666 - Notice of Inventory Completion: Paul H. Karshner Memorial Museum, Puyallup, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ..., 2011. ADDRESSES: Brian Fox, Director of Instructional Leadership, Puyallup School District, Paul H... criteria in 43 CFR 10.11(c)(1) should contact Brian Fox, Director of Instructional Leadership, Paul H...

  13. Effect of Cytomegalovirus Infection on Survival of Older Kidney Transplant Patients (D+/R+): Impact of Valganciclovir Prophylaxis Versus Preemptive Therapy.

    PubMed

    Luna, E; Caravaca, F; Ferreira, F; Fernandez, N; Martín, P; Vargas, M L; Saenz de Santamaría, J; Garcia Pino, G; Azevedo, L; Muñoz Sanz, A

    2016-11-01

    Kidney transplant patients with D+/R+ serology can be treated with either prophylaxis or preemptive valganciclovir. The older transplant population suffers severe immunosenescence, especially patients with latent cytomegalovirus (CMV) infection (R+). They are more likely to develop indirect CMV effects. Likewise, many patients have significant cardiovascular comorbidity, which makes them more sensitive to these indirect effects. The aim of this study was to evaluate the incidence of CMV viremia and indirect effects on survival, comparing prophylaxis (V) against preemptive (P) valganciclovir in an older kidney transplant population. We analyzed the data of 233 recipients from 2002 (age, >55 years; D+/R+) with ≥6 months of follow-up. The patients were divided into 2 groups: 167 (71.7%) in the V group and 66 (28.3%) in the P group. The incidence of CMV infection in the P group was 32% versus 6% in V group. Patients with CMV viremia showed worse survival values than patients without viremia (log rank P = .031). Five-year survivals were 74% vs 88%, respectively. Cox regression showed that the adjusted effect of CMV infection on overall survival was a significant risk (hazard ratio [HR], 2.07; 95% CI, 1.003-4.29). Patients with CMV viremia showed worse cardiovascular survival than patients without viremia, with 5-year survivals of 79% vs 94%. Cox regression showed that the adjusted effect of CMV infection was a significant risk (HR, 2.62). CMV infection has a detrimental effect on the survival of older patients. Valganciclovir prophylaxis induces a protective effect against CMV infection and could improve survival of older patients with cardiovascular comorbidities. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Angiographic evidence of proliferative retinopathy predicts neuropsychiatric morbidity in diabetic patients.

    PubMed

    Serlin, Yonatan; Shafat, Tali; Levy, Jaime; Winter, Aaron; Shneck, Marina; Knyazer, Boris; Parmet, Yisrael; Shalev, Hadar; Ur, Ehud; Friedman, Alon

    2016-05-01

    Diabetic retinopathy (DR) is a common vasculopathy categorized as either non-proliferative (NPDR) or proliferative (PDR),characterized by dysfunctional blood-retinal barrier (BRB) and diagnosed using fluorescein angiography (FA). Since the BRB is similar in structure and function to the blood-brain barrier (BBB) and BBB dysfunction plays a key role in the pathogenesis of brain disorders, we hypothesized that PDR, the severe form of DR, is likely to mirror BBB damage and to predict a worse neuropsychiatric outcome. A retrospective cohort study was conducted among subjects with diabetes (N=2982) with FA-confirmed NPDR (N=2606) or PDR (N=376). Incidence and probability to develop brain pathologies and mortality were investigated in a 10-year follow-up study. We used Kaplan-Meier, Cox and logistic regression analyses to examine association between DR severity and neuropsychiatric morbidity adjusting for confounders. Patients with PDR had significantly higher rates of all-cause brain pathologies (P<0.001), specifically stroke (P=0.005), epilepsy (P=0.006) and psychosis (P=0.024), and a shorter time to develop any neuropsychiatric event (P<0.001) or death (P=0.014) compared to NPDR. Cox adjusted hazard ratio for developing all-cause brain impairments was higher for PDR (HR=1.37, 95% CI 1.16-1.61, P<0.001) which was an independent predictor for all-cause brain impairments (OR 1.30, 95% CI 1.04-1.64, P=0.022), epilepsy (OR 2.16, 95% CI 1.05-4.41, P=0.035) and mortality (HR=1.35, 95% CI 1.06-1.70, P=0.014). This is the first study to confirm that angiography-proven microvasculopathy identifies patients at high risk for neuropsychiatric morbidity and mortality. Copyright © 2016. Published by Elsevier Ltd.

  15. HLA-DRB1 alleles associated with polymyalgia rheumatica in northern Italy: correlation with disease severity

    PubMed Central

    Salvarani, C.; Boiardi, L.; Mantovani, V.; Ranzi, A.; Cantini, F.; Olivieri, I.; Bragliani, M.; Collina, E.; Macchioni, P.

    1999-01-01

    OBJECTIVE—To examine the association of HLA-DRB1 alleles with polymyalgia rheumatica (PMR) in a Mediterranean country and to explore the role of HLA-DRB1 genes in determining disease severity.
METHODS—A five year prospective follow up study of 92 consecutive PMR patients diagnosed by the secondary referral centre of rheumatology of Reggio Emilia, Italy was conducted. HLA-DRB1 alleles were determined in the 92 patients, in 29 DR4 positive rheumatoid arthritis (RA) patients, and in 148 controls from the same geographical area by polymerase chain reaction amplification and oligonucleotide hybridisation.
RESULTS—No significant differences were observed in the frequencies of HLA-DRB1 types and in the expression of HLA-DRB 70-74 shared motif between PMR and controls. The frequency of the patients with double dose of epitope was low and not significantly different in PMR and in controls. No significant differences in the distribution of HLA-DR4 subtypes were observed between DR4+ PMR, DR+ RA, and DR4+ controls. Results of the univariate analysis indicated that an erythrocyte sedimentation rate (ESR) at diagnosis > 72 mm 1st h, the presence of HLA-DR1, DR10, rheumatoid epitope, and the type of rheumatoid epitope were significant risk factors associated with relapse/recurrence. Cox proportional hazards modelling identified two variables that independently increased the risk of relapse/recurrence: ESR at diagnosis > 72 mm 1st h (RR=1.5) and type 2 (encoded by a non-DR4 allele) rheumatoid epitope (RR=2.7).
CONCLUSION—These data from a Mediterranean country showed no association of rheumatoid epitope with PMR in northern Italian patients. A high ESR at diagnosis and the presence of rheumatoid epitope encoded by a non-DR4 allele are independent valuable markers of disease severity.

 PMID:10225816

  16. 78 FR 12411 - Shipping Coordinating Committee Notice of Renewal of Charter

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-22

    ... shorter notice. For further information, please contact: Lieutenant Commander Brian W. Robinson, Executive Secretary, Shipping Coordinating Committee, U.S. Department of State, Office of Oceans Affairs, at Robinson... . Dated: January 22, 2013. Brian W. Robinson, Executive Secretary, Shipping Coordinating Committee...

  17. Educational differences in disability retirement among young employees in Helsinki, Finland.

    PubMed

    Sumanen, Hilla; Rahkonen, Ossi; Pietiläinen, Olli; Lahelma, Eero; Roos, Eira; Lahti, Jouni

    2016-04-01

    Disability retirement (DR) among young employees is an increasing problem affecting work life and public health, given the potential major loss of working time. Little is known about educational differences in the risk of DR among young employees, despite the need for such knowledge in targeting preventive measures. We examined the association between education and DR due to any cause and to mental and non-mental causes among young employees. Personnel register data of the City of Helsinki from the years 2002-2013 for 25-to-34-year-old employees (n= 41225) were linked to register data from the Finnish Centre for Pensions on DR (n= 381), and from Statistics Finland on education. Education was categorised into four hierarchical groups. The mean follow-up time was 5.7 years. Cox regression analysis was used. There were 381 DR events and of the events, over 70% were due to mental disorders and 72% were temporary. A consistent educational gradient was found. Those with a basic education were at the highest risk of DR due to any cause (HR 4.64, 95% CI 3.07, 7.02), and to mental (HR 4.79, 95% CI 2.89, 7.94) and non-mental causes (HR 4.32, 95% CI 2.10, 8.91). DR due to any cause, and to mental and non-mental causes, followed a clear educational gradient. Early intervention, treatment and rehabilitation with a view to maintaining work ability are needed among young employees, especially those with low education. Adapting working conditions to their health and work ability may also help to avoid premature exit from work. © The Author 2015. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

  18. Is a SIMPLe smartphone application capable of improving biological rhythms in bipolar disorder?

    PubMed

    Hidalgo-Mazzei, Diego; Reinares, María; Mateu, Ainoa; Juruena, Mario F; Young, Allan H; Pérez-Sola, Víctor; Vieta, Eduard; Colom, Francesc

    2017-12-01

    Biological rhythms (BR) disturbance has been suggested as a potential mediator of mood episodes in Bipolar Disorder (BD). The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) was designed as an assessment tool to evaluate BR domains comprehensively. In the context of a trial evaluating a smartphone application delivering personalized psychoeducational contents for BD (SIMPLe 1.0), the main aim of this study is to evaluate the potential impact of SIMPLe 1.0 in BR regulation using the BRIAN scale. 51 remitted BD patients were asked to use the application for 3 months. Paired t-test analyses were employed to compare baseline and follow-up BRIAN´s total and domains scores. The sample was divided into completers and non-completers of the study to evaluate differences between groups regarding BRIAN scores using ANCOVA analyses. The BRIAN's mean total score of the whole sample significantly decreased from baseline to post-intervention (35.89 (SD 6.64) vs. 31.18 (SD 6.33), t = 4.29, p = 0.001). At post-intervention, there was a significant difference between groups regarding the total BRIAN mean score (29.47 (SD 6.21) completers vs. 35.92 (SD 3.90) non-completers, t = 2.50, p = 0.02). This difference was maintained after conducting a one-way ANCOVA controlling for pre-intervention BRIAN scores, F (1, 46) = 10.545, p=0.002. A limited sample, pre-post measures, and a short study timeframe could have affected the results. Additional factors affecting BR, such as medication, could not be ruled out. Our results suggest that there are potential positive effects of a psychoeducational smartphone application as an adjunctive to treatment as usual on BD patients' BR. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. The brian simulator.

    PubMed

    Goodman, Dan F M; Brette, Romain

    2009-09-01

    "Brian" is a simulator for spiking neural networks (http://www.briansimulator.org). The focus is on making the writing of simulation code as quick and easy as possible for the user, and on flexibility: new and non-standard models are no more difficult to define than standard ones. This allows scientists to spend more time on the details of their models, and less on their implementation. Neuron models are defined by writing differential equations in standard mathematical notation, facilitating scientific communication. Brian is written in the Python programming language, and uses vector-based computation to allow for efficient simulations. It is particularly useful for neuroscientific modelling at the systems level, and for teaching computational neuroscience.

  20. Competitive Technologies for National Security: Review and Recommendations

    DTIC Science & Technology

    2008-02-29

    Carafano, Brian C. Goebel, and Josh Kussman , “Coming to America: Initiatives for Better, Faster, and More Secure Visas,” Heritage Foundation Backgrounder No...First published as Heritage Foundation Backgrounder No. 2071, September 21, 2007. 20. James Jay Carafano, Brian C. Goebel, and Josh Kussman , “Coming

  1. Q & A with Ed Tech Leaders: Interview with Brian Lewis

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Fulgham, Susan M.

    2013-01-01

    Brian Lewis, International Society for Technology in Education (ISTE) chief executive officer, is an education advocate and leader specializing in management and governance, policy, corporate communications, branding, and marketing. He provides leadership to ISTE's Washington, DC, and Eugene, Oregon, offices and directs organizational…

  2. Finding a Voice

    ERIC Educational Resources Information Center

    Skouge, James R.; Kajiyama, Brian

    2009-01-01

    In this article, the authors relate a story about the transformative power of technologies for voice. They relate Brian Kajiyama's personal odyssey--what might be described as a journey from unvoiced to vocal--in learning to use a DynaWrite, a type-and-talk device that Brian uses as a communication tool.

  3. Guidelines for Hosted Payloads Integration Product Overview

    DTIC Science & Technology

    2014-05-08

    nro.mil NRO Hans Koenigsmann hans.koenigsmann@spacex.com SpaceX James Koory james.koory@rocket.com Rocket Brian Kosinski Kosinski.Brian@ssd.loral.com...Milligen fvanmilligen@jdsu.com JDSU Marvin VanderWeg marvin.vanderwag@spacex.com SpaceX Gerrit VanOmmering gerrit.vanommering@sslmda.com SSL Michael

  4. Rosiglitazone: a disappointing DREAM.

    PubMed

    Nissen, Steven

    2007-09-01

    Dr Steven Nissen is a heart specialist and currently holds the position of chairman of cardiovascular medicine at the Cleveland Clinic, OH, USA. His work has involved the development of miniaturised ultrasound imaging devices that can be threaded into a patient's heart that allow measurement of the size and composition of plaques, which indicate early artery damage. The ability to characterize and measure the size of plaques provided a novel, effective method to evaluate the efficacy of anticholesterol medications, and for the past two decades Dr Nissen has been using these and other techniques to examine the efficacy of drugs. He has also developed a strong interest in drug safety. His work linked COX-2 inhibitors such as Celebrex and Vioxx (Merck, NJ, USA) with heart attacks, and prevented Merck's similar product, Arcoxia, from being approved. He also highlighted the serious heart attack risk associated with the experimental drug Pargluva and the drug was subsequently not approved by the US FDA. More recently, Dr Nissen's work has focused on the drug rosiglitazone, which was shown to have high cardiovascular risks and has since been given a FDA warning. Here, Dr Nissen discusses the publication of the rosiglitazone meta-analysis and why he considers work in this area to be crucially important for patients.

  5. Humanism in Education

    ERIC Educational Resources Information Center

    Armstrong, Michael

    2015-01-01

    This is the text of Michael Armstrong's address to the Brian Simon Centenary conference, held at the Institute of Education on 26 March 2015. Michael Armstrong celebrates the humanism that underlay Brian's belief in a common system of education, democratic and non-selective, and finds its counterpart in the creative practice of school children.

  6. Commercial Acquisition Demystified. How Commercial Satellite Acquisition Conforms to FAR Part 12

    DTIC Science & Technology

    2011-01-01

    Spittle n Brian P. Brodfuehrer n Michael J. Giomi n John Krieger Initiatives announced by Department of Defense Secretary Robert Gates in August...contacted at spittlee@ssd.loral. com, brian.brodfuehrer@dau.mil, giomim@ssd.loral.com, and john . krieger @dau.mil. There is an opportunity to

  7. Personal Area Networks in Tactical Mobile Devices

    DTIC Science & Technology

    2014-08-01

    TECHNICAL DOCUMENT 2047 August 2014 Personal Area Networks in Tactical Mobile Devices Brian Visser...Tactical Mobile Devices Brian Visser Approved for public release. SSC Pacific San Diego, CA 92152-5001 SB...consistent power source, which is normally not available to patrols. In addition to the lack of computer resources, robust network infrastructure

  8. Brian Honyouti: Send in the Clowns

    ERIC Educational Resources Information Center

    Pearlstone, Zena

    2012-01-01

    Hopi Brian Honyouti's "clown" sculptures stem from his personal and political views and comment on commercialism, big business, greed, over indulgence, and irresponsible and sexual behavior. This essay explores the meaning of these carvings to Honyouti, to Hopiit, and to the buying public, as well as their relationship to "tithu," the carved…

  9. At Work in the Genre Laboratory: Brian DePalma's "Scarface."

    ERIC Educational Resources Information Center

    Welsch, Tricia

    1997-01-01

    Postulates that, if genres serve as problem-solving constructs for the cultures they reflect and are fundamentally conservative structures committed to temporary resolutions of the hopeless contradictions that produce their dramas, then Brian DePalma's "Scarface" exemplifies the ways gangster films of the 1980s redefined generic…

  10. Interview with Brian Tomlinson on Humanising Education

    ERIC Educational Resources Information Center

    Nimehchisalem, Vahid

    2016-01-01

    Brian Tomlinson is a Visiting Professor at The University of Liverpool and a Teaching English to Speakers of Other Languages (TESOL) Professor at Anaheim University. He has worked as a teacher, teacher trainer, curriculum developer, university academic and soccer coach in Indonesia, Japan, Nigeria, Oman, Singapore, Vanuatu, UK and Zambia and has…

  11. Technical Risk Identification at Program Inception Product Overview

    DTIC Science & Technology

    2014-05-08

    hans.koenigsmann@spacex.com SpaceX James Koory james.koory@rocket.com Rocket Brian Kosinski Kosinski.Brian@ssd.loral.com SSL John Kowalchik john.j.kowalchik...Marvin VanderWeg marvin.vanderwag@spacex.com SpaceX Gerrit VanOmmering gerrit.vanommering@sslmda.com SSL Michael Verzuh mverzuh@ball.com Ball John Vilja

  12. Root Cause Investigation Best Practices Guide

    DTIC Science & Technology

    2014-05-30

    Koenigsmann hans.koenigsmann@spacex.c om SpaceX James Koory james.koory@rocket.com Rocket Brian Kosinski Kosinski.Brian@ssd.loral.co m SSL John...Fred Van Milligen fvanmilligen@jdsu.com JDSU Marvin VanderWeg marvin.vanderwag@spacex.c om SpaceX Gerrit VanOmmering gerrit.vanommering@sslmda. com SSL

  13. RF Breakdown Prevention in Spacecraft Components Product Overview

    DTIC Science & Technology

    2014-05-08

    Koenigsmann SpaceX hans.koenigsmann@spacex.com James Koory Rocket james.koory@rocket.com Brian Kosinski SSL Kosinski.Brian@ssd.loral.com John Kowalchik...fvanmilligen@jdsu.com Marvin VanderWeg SpaceX marvin.vanderwag@spacex.com Gerrit VanOmmering SSL gerrit.vanommering@sslmda.com Michael Verzuh Ball mverzuh

  14. Alpine Palaeogeography: new constraints from detrital zircon geochronology

    NASA Astrophysics Data System (ADS)

    Galster, Federico; Stockli, Daniel

    2017-04-01

    Schardt's (1898) discovery of the "allochtony" of the Préalpes Médianes and its exotic character, provided Alpine geologist with a first picture of Alpine palaeogeography: a Middle Jurassic sea divided in two branches by the rise of an emerged island. Later on, Schardt's island had been recognized at the scale of the Alpine belt and took the name of Briançonnais "geoanticline". In many Alpine palaeogeographic reconstructions, the Briançonnais and its exotic character have played a crucial role (e.g. Stampfli 1993; Manatschal et al., 2006;). In particular some of them explained the exotic character of the Briançonnais facies by proposing a pre-Cretaceous position located far from the Helvetic domain. In this view, the Briançonnais terrain was related to the Iberian plate and entered the Central Alpine system only after a Lower Cretaceous eastward drift associated with anticlockwise rotation of Iberia, opening of the northern Atlantic and closure of the Vardar ocean. In the Central Alps, the remnants of the northern Jurassic margin of the Alpine Tethys (sensu Stampfli) are contained in the Helvetic (s.l.) and Lower Penninic units. The basements and original substrate of these nappes are exposed in the crystalline external massifs and in the gneissic Lepontine dome. The highest, more internal, gneissic units within this dome are the Monte Leone, the Maggia and the Adula nappe. Theses units, as well as the autochthonous basement of the European margin, are characterized by large "Variscan" granitoids with ages between 290 and 330 Ma. The "ophiolite-bearing" units thrust on top of the Adula nappe are composed of Cretaceous and younger sedimentary rocks, with thin soles of Triassic and Jurassic strata. In addition to Variscan, Cambro-Ordovician and Proterozoic ages, detrital zircons in these soles show a peak at 260-280 Ma accompanied by a cluster of ca. 230 Ma zircons, similarly to what is observed in the Schams and Préalpes Médianes nappes (Briançonnais s.l.). This is particularly evident in the Tomul nappe, located at the top of the Lower Penninic pile below Briançonnais-derived units and in the Piz Terri-Lunschania zone (PTLZ), tectonically located between the Adula nappe and the "ophiolite-bearing" Grava nappe. In the PTLZ a Permo-Triassic of Briançonnais type is in stratigraphic contact with a Lower Jurassic of Helvetic type. Detrital zircon signatures in the Lower Jurassic sandstones of the PTLZ are very similar to those of the Helvetic. In contrast, locally sourced Permian and Middle Jurassic strata of the PTLZ show two remarkable features: a peak at 260-280Ma and the scarcity or absence of Variscan zircons (gap between 290 and 350Ma). Considering the basement of the different alpine domains, this characteristic is best explained by a Briançonnais-type basemet source that lacks widespread Variscan intrusions and is characterized by large "mid Permian" intrusions. The occurrence of different types of Briançonnais DZ U-Pb signatures in the pre-Cretaceous stratigraphic record of the distal Helvetic-North Penninic margin favors a Jurassic palaeogeography with the Briançonnais domain located south of the Helvetic domain and not directly related to the Iberian plate and its Cretaceous tectonic juxtaposition.

  15. Incidence and Risk Factors for Developing Diabetic Retinopathy among Youths with Type 1 or Type 2 Diabetes throughout the United States.

    PubMed

    Wang, Sophia Y; Andrews, Chris A; Herman, William H; Gardner, Thomas W; Stein, Joshua D

    2017-04-01

    Despite the increasing prevalence of type 2 diabetes mellitus (T2DM) among children and adolescents, little is known about their risk of developing diabetic retinopathy (DR). We sought to identify risk factors for DR in youths with diabetes mellitus, to compare DR rates for youths with type 1 diabetes mellitus (T1DM) and those with T2DM, and to assess whether adherence to DR screening guidelines promoted by the American Academy of Ophthalmology, American Academy of Pediatrics, and American Diabetes Association adequately capture youths with DR. Retrospective observational longitudinal cohort study. Youths aged ≤21 years with newly diagnosed T1DM or T2DM who were enrolled in a large US managed-care network. In this study of youths aged ≤21 years with newly diagnosed T1DM or T2DM who were under ophthalmic surveillance, we identified the incidence and timing of DR onset. Kaplan-Meier survival curves assessed the timing of initial diagnosis of DR for participants. Multivariable Cox proportional hazard regression modeling identified factors associated with the hazard of developing DR. Model predictors were age and calendar year at initial diabetes mellitus diagnosis, sex, race/ethnicity, net worth, and glycated hemoglobin A 1c fraction (HbA 1c ). Hazard ratios (HRs) with 95% confidence intervals (CIs) for developing DR. Among the 2240 youths with T1DM and 1768 youths with T2DM, 20.1% and 7.2% developed DR over a median follow-up time of 3.2 and 3.1 years, respectively. Survival curves demonstrated that youths with T1DM developed DR faster than youths with T2DM (P < 0.0001). For every 1-point increase in HbA 1c , the hazard for DR increased by 20% (HR = 1.20; 95% CI 1.06-1.35) and 30% (HR = 1.30; 95% CI 1.08-1.56) among youths with T1DM and T2DM, respectively. Current guidelines suggest that ophthalmic screening begin 3 to 5 years after initial diabetes mellitus diagnosis, at which point in our study, >18% of youths with T1DM had already received ≥1 DR diagnosis. Youths with T1DM or T2DM exhibit a considerable risk for DR and should undergo regular screenings by eye-care professionals to ensure timely DR diagnosis and limit progression to vision-threatening disease. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  16. Synergistic Effect of Nitrogen in Cobalt Nitride and Nitrogen-Doped Hollow Carbon Spheres for Oxygen Reduction Reaction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhong, Xing; Liu, Lin; Jiang, Yu

    The need for inexpensive and high-activity oxygen reduction reaction (ORR) electrocatalysts has attracted considerable research interest over the past years. Here we report a novel hybrid that contains cobalt nitride/nitrogen-rich hollow carbon spheres (CoxN/NHCS) as a high-performance catalyst for ORR. The CoxN nanoparticles were uniformly dispersed and confined in the hollow NHCS shell. The performance of the resulting CoxN/NHCS hybrid was comparable with that of a commercial Pt/C at the same catalyst loading toward ORR, but the mass activity of the former was 5.7 times better than that of the latter. The nitrogen in both CoxN and NHCS, especially CoxN,more » could weaken the adsorption of reaction intermediates (O and OOH), which follows the favourable reaction pathway on CoxN/NHCS according to the DFT-calculated Gibbs free energy diagrams. Our results demonstrated a new strategy for designing and developing inexpensive, non-precious metal electrocatalysts for next-generation fuels. The authors acknowledge the financial support from the National Basic Research Program (973 program, No. 2013CB733501) and the National Natural Science Foundation of China (No. 21306169, 21101137, 21136001, 21176221 and 91334013). Dr. D. Mei is supported by the US Department of Energy (DOE), Office of Science, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences & Biosciences. Pacific Northwest National Laboratory (PNNL) is a multiprogram national laboratory operated for DOE by Battelle. Computing time was granted by the grand challenge of computational catalysis of the William R. Wiley Environmental Molecular Sciences Laboratory (EMSL). EMSL is a national scientific user facility located at Pacific Northwest National Laboratory (PNNL) and sponsored by DOE’s Office of Biological and Environmental Research.« less

  17. Rethinking Cultural Influences on Warfare

    DTIC Science & Technology

    2012-05-17

    36 Jarole B. Manheim, Richard C. Lars Willnat, and Craig Brians , Empirical Political...Willnat, and Craig Brians , Empirical Political Analysis: Quantitative and Qualitative Research Methods (New York: Pearson Education Inc, 2008... Boxer Rebellions. In 1950, China was emerging from 13 years of protracted warfare with Japan and a civil war between the Chinese Communist Party (CCP

  18. Interview with Brian Kotz: Data Science at Two-Year Colleges

    ERIC Educational Resources Information Center

    Rossman, Allan; Kotz, Brian

    2018-01-01

    Brian Kotz is Professor of Mathematics and Statistics at Montgomery College. He is a former member of the American Statistical Association/American Mathematical Association of Two-Year Colleges (ASA)/(AMATYC) Joint Committee and the current chair of the AMATYC Data Science Subcommittee. This interview took place via email on November 23,…

  19. Connecting Brian Cambourne's Conditions of Learning Theory to Brain/Mind Principles: Implications for Early Childhood Educators.

    ERIC Educational Resources Information Center

    Rushton, Stephen P.; Eitelgeorge, Janice; Zickafoose, Ruby

    2003-01-01

    Relates each of the eight conditions of learning in Brian Cambourne's theory of literacy to findings in brain research within a constructivist approach to early childhood education. Cites sample classroom dialogues demonstrating classroom elements that foster a brain-based, developmentally appropriate learning environment supporting Cambourne's…

  20. Note on Conditional Compilation in Standard ML

    DTIC Science & Technology

    1993-06-01

    eOmputer-Science No-te on Coridhitiom Cominliati"I~n Standard ML1 Nicholas Haines Edoardo Biagioni Robert Hiarper mom Brian G. Mimnes June 1993 CMU...CS-93. 11 TIC ELECTE f 00..7733 %goo~~OO Note on Conditioual Compilation in Standard ML Nicholas Haines Edoardo Biagioni Robert Harper Brian G. Milnes

  1. Novel Techniques for Retroperitoneal Implantation of Telemetry Transmitters for Physiologic Monitoring in Gottingen Minipigs (Sus scrofa domesticus)

    DTIC Science & Technology

    2014-12-01

    scrofa domesticus) Scott Willens,1,* David M Cox,3 Ernest H Braue,1 Todd M Myers,1 and Matthew D Wegner2 Telemetric monitoring of physiologic parameters...BMC Vet Res 4:51. 15. Hulet SW, Sommerville DR, Crosier RB, Dabisch PA, Miller DB, Benton BJ, Forster JS, Scotto JA, Jarvis JR , Krauthauser C...domestic white pig. Basic Clin Pharmacol Toxicol 97:35–38. 6. Crawshaw GJ, Mills KJ, Mosley C, Patterson BR. 2007. Field im- plantation of

  2. Common variants of HNF1A gene are associated with diabetic retinopathy and poor glycemic control in normal-weight Japanese subjects with type 2 diabetes mellitus.

    PubMed

    Morita, Kazunori; Saruwatari, Junji; Tanaka, Takahiro; Oniki, Kentaro; Kajiwara, Ayami; Miyazaki, Hiroko; Yoshida, Akira; Jinnouchi, Hideaki; Nakagawa, Kazuko

    2017-02-01

    This study investigated the associations between the common hepatocyte nuclear factor-1A (HNF1A) variants and the risk of diabetic retinopathy (DR) in relation to the glycemic control and weight status. A retrospective longitudinal analysis was conducted among 354 Japanese patients with type 2 diabetes mellitus (T2DM) (mean follow-up duration: 5.8±2.5 years). The multivariable-adjusted hazard ratio (HR) for the cumulative incidence of DR was calculated using a Cox proportional hazard model. During the observation period, the longitudinal associations of the HNF1A diplotypes with the risk of DR and the clinical parameters were also analyzed using the generalized estimating equations approach. The combination of risk variants, i.e., rs1169288-C, rs1183910-A and rs2464196-A, was defined as the H1 haplotype. The incidence of DR was higher in the H1/H1 diplotype cases than in the others (HR 2.75 vs. non-H1/non-H1; p=0.02). Only in normal-weight subjects, the risks of DR and poor glycemic control were higher in the H1/H1 diplotype cases than in the others [odds ratio 4.08 vs. non-H1/non-H1, p=0.02; odds ratio 3.03, p=0.01; respectively]. This study demonstrated that the common HNF1A diplotype of three risk variants may be an independent risk factor for the development of DR resulting from poor glycemic control in normal-weight patients with T2DM. These results need to be replicated in larger and more varied study populations. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Network Science Experimentation Vision

    DTIC Science & Technology

    2015-09-01

    Brian Rivera, Kevin Chan, Lisa Scott, Reginald Hobbs, Alice Leung, Will Dron , and Ritu Chadha Approved for public...release; distribution is unlimited. NOTICES Disclaimers The findings in this report are not to be construed as an official Department of the...Kott, Brian Rivera, Kevin Chan, Lisa Scott, and Reginald Hobbs Computational and Information Sciences Directorate, ARL Alice Leung and Will Dron

  4. Tools for Rapid Understanding of Malware Code

    DTIC Science & Technology

    2015-05-07

    cloaking techniques. We used three malware detectors, covering a wide spectrum of detection technologies, for our experiments: VirusTotal, an online ...Analysis and Manipulation ( SCAM ), 2014. [9] Babak Yadegari, Brian Johannesmeyer, Benjamin Whitely, and Saumya Debray. A generic approach to automatic...and Manipulation ( SCAM ), 2014. [9] Babak Yadegari, Brian Johannesmeyer, Benjamin Whitely, and Saumya Debray. A generic approach to automatic

  5. A Second Look at Brian Simon's "Bending the Rules"

    ERIC Educational Resources Information Center

    Cox, Sue

    2016-01-01

    In this article the author revisits an important book: Brian Simon's "Bending the Rules: the Baker reform of education." Written by a key figure in the history of the journal FORUM as well as in the history of education, Simon's book documented the features of the Education Reform Bill of 1987 (the precursor to the Education Reform Act…

  6. The Return of the Mentor: Strategies for Workplace Learning. Education Policy Perspectives Series.

    ERIC Educational Resources Information Center

    Caldwell, Brian J., Ed.; Carter, Earl M. A., Ed.

    This book contains the following papers about the framework of mentoring as a workplace learning strategy and the role of mentoring the education, health, and industrial cultures: "Preface" (Brian J. Caldwell, Earl M.A. Carter); "The Workplace of the 1990s" (Brian J. Caldwell, Earl M.A. Carter); "The Principles and…

  7. Incidence and Risk Factors for Developing Diabetic Retinopathy Among Youth with Type 1 and Type 2 Diabetes Throughout the United States

    PubMed Central

    Wang, Sophia Y.; Andrews, Chris A.; Herman, William H.; Gardner, Thomas W.; Stein, Joshua D.

    2017-01-01

    Objectives Despite the increasing prevalence of Type 2 diabetes mellitus (T2DM) among children and adolescents, little is known about their risk of developing diabetic retinopathy (DR). We sought to identify risk factors for DR in youth with DM, to compare DR rates for youth with Type 1 diabetes mellitus (T1DM) and T2DM, and to assess whether adherence to DR screening guidelines promoted by the American Academy of Ophthalmology, American Academy of Pediatrics, and American Diabetes Association adequately capture youth with DR. Design Retrospective observational longitudinal cohort study. Participants Youth aged ≤ 21 years with newly diagnosed T1DM or T2DM enrolled in a large U.S. managed care network. Main Outcome Measure Hazard ratios (HR) with 95% confidence intervals (CIs) for developing DR. Methods In this study of youth aged ≤ 21 years with newly diagnosed T1DM or T2DM enrolled in a large U.S. managed care network who were under ophthalmic surveillance, we identified the incidence and timing of DR onset for youth with T1DM and T2DM. Kaplan-Meier survival curves assessed the timing of initial diagnosis of DR for youth with each type of diabetes. Multivariable Cox proportional hazard regression modeling identified factors associated with the hazard of developing DR. Model predictors were age and calendar year at initial diabetes mellitus diagnosis, sex, race/ethnicity, net worth, and glycosylated hemoglobin (HbA1c). Results Among the 2240 youth with T1DM and 1768 youth with T2DM, 20.1% and 7.2% developed DR, over a median follow-up of 3.2 and 3.1 years, respectively. Survival curves demonstrated that youth with T1DM developed DR faster than youth with T2DM (P<0.0001). For every one-point increase in HbA1c, the hazard for DR increased by 20% (HR=1.20, CI 1.06–1.35) and 30% (HR=1.30, CI 1.08–1.56) among youth with T1DM and T2DM, respectively. Current guidelines suggest ophthalmic screening begin 3–5 years after initial DM diagnosis, at which point in our study, over 18% of youth with T1DM had already had received ≥1 DR diagnosis. Conclusions Youth with T1DM or T2DM exhibit a considerable risk for DR and should undergo regular screenings by eye-care professionals to ensure timely DR diagnosis and limit progression to vision-threatening disease. PMID:27914837

  8. Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burgos, W.D.

    2009-09-02

    This report summarizes research conducted in conjunction with a project entitled “Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center”, which was funded through the Integrative Studies Element of the former NABIR Program (now the Environmental Remediation Sciences Program) within the Office of Biological and Environmental Research. Dr. William Burgos (The Pennsylvania State University) was the overall PI/PD for the project, which included Brian Dempsey (Penn State), Gour-Tsyh (George) Yeh (Central Florida University), and Eric Roden (formerly at The University of Alabama, now at the University of Wisconsin) as separately-fundedmore » co-PIs. The project focused on development of a mechanistic understanding and quantitative models of coupled Fe(III)/U(VI) reduction in FRC Area 2 sediments. The work builds on our previous studies of microbial Fe(III) and U(VI) reduction, and was directly aligned with the Scheibe et al. ORNL FRC Field Project at Area 2.« less

  9. Skylab

    NASA Image and Video Library

    1972-08-21

    Youngstown, Ohio high school student, W. Brian Dunlap (center), discusses with Dr. Robert Head (right), and Henry Floyd, both of the Marshall Space Flight Center (MSFC), his experiment to be performed aboard the Skylab the following year. His experiment, “Wave Motion Trough A Liquid in Zero Gravity” used a container attached to the end of a leaf spring which was oscillated at specific rates using two thickness differentiated types of liquids. Dunlap was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year’s Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment. The equipment for the experiments was manufactured at MSFC.

  10. Training Adult Educators. Proceedings of a National Conference (2nd, Wodonga, Victoria, Australia, May 25-28, 1985). The AAAE Monograph Series in Adult and Continuing Education Number Two.

    ERIC Educational Resources Information Center

    Peace, Brian, Ed.; Foster, Keith, Ed.

    The following papers are included: "Setting the Scene" (Brian Peace); "Different Training for Different Adult Educators?" (Michael Newman); "The Training of Part-Time Teachers in Adult Education: The UK Experience" (Brian Graham); "Adult Education Tutor Support" (Aileen Kelly); "Six Category…

  11. How Insurgencies End

    DTIC Science & Technology

    2010-01-01

    Peter Chalk, Sara  A. Daly, Brian A. Jackson, Seth G. Jones, William Rosenau, Paraag Shukla, and Anna-Marie Vilamovska conducted the quantita- tive...T. Hosmer, Daniel Byman, Jasen J. Castillo, Katharine Watkins Webb, John Gordon, and Christopher Paul all offered men- torship and critical guidance...Peter Chalk, Sara Daly, Brian Jackson, Seth Jones, Martin Libicki, Bill Rosenau, Paraag Shukla, and Anna-Marie Vilamovska formed the research staff

  12. Trick or Treat or Trouble: Featuring Brian McDaniel. The Kids on the Block Book Series.

    ERIC Educational Resources Information Center

    Aiello, Barbara; Shulman, Jeffrey

    One of a series of children's books written from the point of view of an elementary grade child with a disability or other problem, the stories emphasize the similarities in childhood experience while providing information specific to the disability. In this book, fifth-grader Brian, who has epilepsy, finds that his misconceptions about a funeral…

  13. A Study in Teaching CPR to a Disabled Student

    ERIC Educational Resources Information Center

    Brady, Bill; Sanders, Cindy

    2004-01-01

    This article describes a CPR training course modified for a student with cerebral palsy. Brian is a 10th grade student with cerebral palsy affecting his right side. Brian had a difficult time in the class and was not able to meet the standards required to pass his CPR training. Here, the author discusses how two adaptations were utilized, that…

  14. Caspian Sea Environmental Security Game: 16-17 November 1998

    DTIC Science & Technology

    1999-07-01

    17 Robert E. Ebel Caspian Basin Oil and Gas: An Overview . . . . . . . . . . . 21 Brian R . Shaw Environmental Baseline...threat to security of supply. 32 ENVIRONMENTAL BASELINE ANALYSIS OF THE CASPIAN SEA REGION BRIAN R . SHAW TERRY PALUSZKIEWICZ SUSAN A. THOMAS...Caspian Sea level. Sources of water include runoff ( R ), precipitation (P), and groundwater flow (G); sink include evaporation (E), and discharge of water

  15. Q&A: Brian Greene on music and string theory

    NASA Astrophysics Data System (ADS)

    Hoffman, Jascha

    2010-05-01

    Brian Greene, author of best-selling books The Elegant Universe and The Fabric of the Cosmos, is a theoretical physicist at Columbia University, New York. As an orchestral work based on his 2008 children's book, Icarus at the Edge of Time, premieres next week, Greene discusses black holes and how music might portray the physics of warped space-time.

  16. Higher levels of physical activity are independently associated with a lower incidence of diabetic retinopathy in Japanese patients with type 2 diabetes: A prospective cohort study, Diabetes Distress and Care Registry at Tenri (DDCRT15).

    PubMed

    Kuwata, Hirohito; Okamura, Shintaro; Hayashino, Yasuaki; Tsujii, Satoru; Ishii, Hitoshi

    2017-01-01

    We assessed the prospective association between baseline levels of physical activity (PA) and the incidence of newly developed diabetic retinopathy (DR) in patients with type 2 diabetes. Data from 1,814 patients with type 2 diabetes without DR were obtained from a Japanese diabetes registry at Tenri Hospital, Nara, Japan. To assess the independent correlations between baseline PA levels and newly developed DR, the participants were divided into five categories based on their PA levels. A Cox proportional hazards model with time-varying exposure information was used and adjusted for potential confounders to assess the independent correlations. At baseline, the mean age, BMI, and hemoglobin A1c levels of the patients were 65.5 years, 24.5 kg/m2, and 7.2% (54 mmol/mol), respectively. After 2 years, newly developed DR was confirmed in 184 patients (10.1%). Patients with newly developed DR had longer duration of type 2 diabetes (14.7 versus 11.0 years, p < 0.0001), higher systolic blood pressure (139.2 versus 135.1 mmHg, p = 0.0012), lower estimated glomerular filtration rate (74.0 versus 77.1 mL/min/1.73 m2, p = 0.0382), greater urinary albumin-creatinine ratio (4.00 versus 2.45 mg/mmol, p < 0.0039), and higher HbA1c levels (7.5 versus 7.2%, p = 0.0006) than those without newly developed DR. The multivariable-adjusted hazard ratios for DR development were 0.87 (95% CI, 0.53-1.40; p = 0.557), 0.83 (95% CI, 0.52-1.31; p = 0.421), 0.58 (95% CI, 0.35-0.94; p = 0.027), and 0.63 (95% CI, 0.42-0.94; p = 0.025)for the second, third, fourth, and fifth PA categories, respectively, compared with the reference category of patients with a mean PA of 0 metabolic equivalent of task-hours/week). Higher PA levels are independently associated with a lower incidence of DR in Japanese patients with type 2 diabetes.

  17. Germany, the European Union, and the Euro: The Primacy of Politics in Treasure

    DTIC Science & Technology

    2013-09-01

    2 Brian Blackstone and Charles Forelle, “Germany, France Back Pledge to Save Euro,” The Wall Street Journal, July 27...member 114 Blackstone , “Germany, France Back Pledge to Save Euro.” 115 Liz Alderman, “Right-Wing...Pontusson, eds. Coping with Crisis: Government Reactions to the Great Recession. New York: Russell Sage Foundation, 2012. 76 Blackstone , Brian and

  18. A People's History of Education: Brian Simon, the British Communist Party and "Studies in the History of Education, 1780-1870"

    ERIC Educational Resources Information Center

    McCulloch, Gary

    2010-01-01

    Brian Simon's "Studies in the History of Education", 1780-1870, published in 1960, set out to counter nearly all work previously produced on the history of education in Britain in this period, and to direct the field towards a new course. It provided a Marxist perspective that drew upon Simon's involvement in campaigns for educational…

  19. A Taxonomy of Operational Risks

    DTIC Science & Technology

    2005-09-01

    the operational organization. Con - tractual constraints or requirements can impose risk if the mission delivers products or services under contract...Carnegie Mellon Software Engineering Institute A Taxonomy of Operational Risks CMU/SEI-2005-TN-036 Brian P. Gallagher Pamela J. Case DIST...Operational Risks CMU/SEI-2005-TN-036 Brian P. Gallagher Pamela J. Case Rita C. Creel Susan Kushner Ray C. Williams September2005 Acquisition Support Program

  20. A Critical Analysis of Attribute Development Programs for Army Leaders

    DTIC Science & Technology

    2016-06-10

    40 Col. Brian Michelon, “Character Development of U.S. Army Leaders: The Laissez - Faire Approach,” Military Review (2013...Accessed January 1, 2016. https://hbr.org/2001/12/what-leaders-really-do. Michelon, Brian. “Character Development of U.S. Army Leaders: The Laissez - Faire ...Leavenworth, Kansas 2016 Approved for public release; distribution is unlimited. Fair use determination or copyright permission has been obtained

  1. Cryomilling of Thermoplastic Powder for Prepreg Applications

    DTIC Science & Technology

    2013-09-01

    Cryomilling of Thermoplastic Powder for Prepreg Applications by Brian Parquette, Anit Giri, Daniel J. O’Brien, Sarah Brennan, Kyu Cho, and...MD 21005-5066 ARL-TR-6591 September 2013 Cryomilling of Thermoplastic Powder for Prepreg Applications Brian Parquette and Sarah Brennan...COVERED (From - To) 1 March 2012–30 May 2013 4. TITLE AND SUBTITLE Cryomilling of Thermoplastic Powder for Prepreg Applications 5a. CONTRACT

  2. Bioinspired Surface Treatments for Improved Decontamination: Slippery Omniphobic Covalently Attached Liquid (SOCAL)

    DTIC Science & Technology

    2017-12-13

    Omniphobic Covalently Attached Liquid (SOCAL) December 13, 2017 Approved for public release; distribution is unlimited. Brandy J. White Brian J. Melde...Bioinspired Surface Treatments for Improved Decontamination: Slippery Omniphobic Covalently Attached Liquid (SOCAL) Brandy J. White, Brian J. Melde, Anthony...decontamination capabilities for painted surfaces. This report details results for evaluation of a slippery omniphobic covalently attached liquid (SOCAL) and

  3. Politics and the People: Brian Simon and the Campaign against Intelligence Tests in British Schools

    ERIC Educational Resources Information Center

    Thom, Deborah

    2004-01-01

    The campaign against testing is a good place to reflect on the legacy of Brian Simon and to ask how far his politics and his professional life came together in what he himself called 'Education as a site of struggle'. History of education can be a critical discourse enabling reflection on the effects of policy and practice and the history of…

  4. A Communication Protocol for CyAMS and the Cyber Fighter Associate Interface

    DTIC Science & Technology

    2015-05-01

    by David Harman , Scott Brown, Brian Henz, and Lisa M Marvel Approved for public release; distribution unlimited...Laboratory A Communication Protocol for CyAMS and the Cyber Fighter Associate Interface by David Harman College Qualified Leaders Student...CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) David Harman , Scott Brown, Brian Henz, and Lisa M Marvel 5d. PROJECT

  5. Caspian Sea International Environmental Security Game. Held at Carlisle Barracks, Pennsylvania on 16-17 November 1998

    DTIC Science & Technology

    1999-07-01

    Environmental Security . . . . . . . . . . . . . . . . . . . . 17 Robert E. Ebel Caspian Basin Oil and Gas: An Overview . . . . . . . . . . . 21 Brian R ...choke point near Baku, posing a threat to security of supply. 32 ENVIRONMENTAL BASELINE ANALYSIS OF THE CASPIAN SEA REGION BRIAN R . SHAW TERRY...up to 70% of the seasonal Caspian Sea level. Sources of water include runoff ( R ), precipitation (P), and groundwater flow (G); sink include

  6. An Automated Weather Research and Forecasting (WRF)-Based Nowcasting System: Software Description

    DTIC Science & Technology

    2013-10-01

    14. ABSTRACT A Web service /Web interface software package has been engineered to address the need for an automated means to run the Weather Research...An Automated Weather Research and Forecasting (WRF)- Based Nowcasting System: Software Description by Stephen F. Kirby, Brian P. Reen, and...Based Nowcasting System: Software Description Stephen F. Kirby, Brian P. Reen, and Robert E. Dumais Jr. Computational and Information Sciences

  7. Association between aldehyde dehydrogenase 2 polymorphisms and the incidence of diabetic retinopathy among Japanese subjects with type 2 diabetes mellitus.

    PubMed

    Morita, Kazunori; Saruwatari, Junji; Miyagawa, Haruna; Uchiyashiki, Yoshihiro; Oniki, Kentaro; Sakata, Misaki; Kajiwara, Ayami; Yoshida, Akira; Jinnouchi, Hideaki; Nakagawa, Kazuko

    2013-09-13

    Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies reactive aldehydes in the micro- and macrovasculature. These substrates, including methylglyoxal and 4-hydroxynonenal formed from glucose and lipids, cause protein carbonylation and mitochondrial dysfunction, forming advanced glycation end products (AGEs). The present study aimed to confirm the association between the inactive ALDH2*2 allele and diabetic retinopathy (DR). A retrospective longitudinal analysis was conducted, among 234 Japanese patients with type 2 diabetes mellitus (DM) (156 males and 78 females) who had no DR signs at baseline and were treated for more than half a year. The ALDH2*1/*2 alleles were determined using a real-time TaqMan allelic discrimination assay. Multivariate-adjusted hazard ratios (HRs) and 95% confidential intervals (CIs) for the cumulative incidence of the development of DR were examined using a Cox proportional hazard model, taking drinking habits and the serum γ-glutamyltransferase (GGT) level into consideration. The frequency of the ALDH2*2 allele was 22.3%. Fifty-two subjects cumulatively developed DR during the follow-up period of 5.5 ± 2.5 years. The ALDH2*2 allele carriers had a significantly higher incidence of DR than the non-carriers (HR: 1.92; P = 0.02). The incidence of DR was significantly higher in the drinkers with the ALDH2*2 allele than in those with the ALDH2*1/*1 genotype (HR: 2.61; P = 0.03), while the incidence of DR in the non-drinkers did not differ significantly between the ALDH2 genotype groups (P > 0.05). The incidence of DR was significantly higher in the ALDH2*2 allele carriers with a high GGT level than in the non-carriers with a high or low GGT level (HR: 2.45; P = 0.03; and HR: 2.63; P = 0.03, respectively). To the best of our knowledge, this is the first report of a significant association between the ALDH2*2 allele and the incidence of DR. These findings provide additional evidence that ALDH2 protects both microvasculature and macrovasculature against reactive aldehydes generated under conditions of sustained oxidative stress, although further investigations in larger cohorts are needed to verify the results.

  8. Using Heart Rate to Predict Resilience and Susceptibility to PTSD in Soldiers

    DTIC Science & Technology

    2011-04-01

    Predict Resilience and Susceptibility to PTSD in Soldiers Authors Brian Chung Jonathan Lanier Lolita M. Burrell Michael D. Matthews...AUTHOR(S) Brian Chung; Jonathan Lanier; Lolita Burrell; Michael Matthews 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING...members of the control group were matched with one of the trauma or PTSD victims based on age and sex and both individuals were shown the same

  9. Accelerated Corrosion Results for Zinc/Nickel-Plated Automotive Parts Posttreated With Trivalent Chromate Rinse

    DTIC Science & Technology

    2010-09-01

    400 and 300 h in neutral salt spray. 5 Similarly plated samples post treated with trivalent chromium rinse lasted 450 and 200 h in neutral salt...Accelerated Corrosion Results for Zinc/Nickel-Plated Automotive Parts Posttreated With Trivalent Chromate Rinse by Chris E. Miller, Brian E...Posttreated With Trivalent Chromate Rinse Chris E. Miller and Brian E. Placzankis Weapons and Materials Research Directorate, ARL I. Carl Handsy

  10. Development of a Native Fractionation Antigen Microarray for Autoantibody Profiling in Breast Cancer

    DTIC Science & Technology

    2011-10-01

    Antigen Microarray for Autoantibody Profiling in Breast Cancer PRINCIPAL INVESTIGATOR: Brian C.-S. Liu, Ph.D...Profiling in Breast Cancer 5b. GRANT NUMBER W81XWH-09-1-0684 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Brian C.-S. Liu...NOTES 14. ABSTRACT The humoral response of a cancer patient may allow earlier detection of cancer than current methods allow. If so, the serum

  11. Medical Robotic and Telesurgical Simulation and Education Research

    DTIC Science & Technology

    2012-09-01

    Deutsch • Gerard Doherty • Brian Dunkin • Susan Dunlow • Gary Dunnington • Ricardo Estape • Peter Fabri • Vicenzo Ficarra • Marvin Fried • Gerald...Prokar Dasgupta • Ellen Deutsch • Gerard Doherty • Brian Dunkin • Susan Dunlow • Gary Dunnington • Ricardo Estape • Peter Fabri • Vicenzo Ficarra...further frontiers for more effective management or even a potential cure for several diseases . However, with the exponential growth of technology in

  12. Profile: Brian Schmidt

    NASA Astrophysics Data System (ADS)

    Bhathal, Ragbir

    2012-02-01

    Brian Schmidt was awarded the Nobel Prize for Physics in 2011 along with Saul Perlmutter and Adam Riess. He is a Fellow of the Australian Academy of Science and of the US National Academy of Sciences. Schmidt has made significant contributions in observational cosmology, supernovae, gamma-ray bursts and all-sky surveys. Ragbir Bhathal interviewed him in 2006 for the National Oral History Project on significant Australian Astronomers sponsored by the National Library of Australia. (Photos: Belinda Pratten)

  13. Understanding and Controlling the Electronic Properties of Graphene Using Scanning Probe Microscopy

    DTIC Science & Technology

    2014-07-21

    Dirac point in gated bilayer graphene, Applied Physics Letters, (12 2009): 243502. doi : 10.1063/1.3275755 Brian J. LeRoy, Adam T. Roberts, Rolf...of soliton motion and stacking in trilayer graphene, Nature Materials , (04 2014): 0. doi : 10.1038/nmat3965 Matthew Yankowitz, Joel I-Jan Wang...of bilayer graphene via quasiparticle scattering, APL Materials , (09 2014): 92503. doi : Matthew Yankowitz, Fenglin Wang, Chun Ning Lau, Brian J

  14. Astronauts Brian Duffy, in commander's seat, and Winston E. Scott discuss their scheduled flight

    NASA Technical Reports Server (NTRS)

    1996-01-01

    STS-72 TRAINING VIEW --- Astronauts Brian Duffy, in commander's seat, and Winston E. Scott discuss their scheduled flight aboard the Space Shuttle Endeavour. The two are on the flight deck of the Johnson Space Center's (JSC) fixed base Shuttle Mission Simulator (SMS). Duffy, mission commander, and Scott, mission specialist, will be joined for the winter flight by three other NASA astronauts and an international mission specialist representing NASDA.

  15. Source Contributions at Regional Distances

    DTIC Science & Technology

    1991-05-14

    Reston, VA 22091 Pasadena, CA 91125 Mr. William J. Best Prof. F. A. Dahlen 907 Westwood Drive Geological and Geophysical Sciences Vienna, VA 22180...PL-TR-91-2130 AD-A240 859 SOURCE CONTRIBUTIONS AT REGIONAL DISTANCES Karl Koch William Soroka Brian Stump Southern Methodist University Department of... William Soroka. Brian Stumo 13a. TYPE OF REPORT 13b. TIME COVERED 114 DATE OF REPORT (Year, Month, Day) 115. PAGE COUNT Final ReDort I FROM09AUG88

  16. L to R: STS-98 Mission Specialist Thomas Jones, Pilot Mark Polansky, and Commander Kenneth Cockrell greet STS-92 Commander Brian Duffy, Dryden Center Director Kevin Petersen, and AFFTC Commander Major General Richard Reynolds

    NASA Image and Video Library

    2001-02-20

    L to R: STS-98 Mission Specialist Thomas Jones, Pilot Mark Polansky, and Commander Kenneth Cockrell greet STS-92 Commander Brian Duffy, Dryden Center Director Kevin Petersen, and AFFTC Commander Major General Richard Reynolds after landing on the runway at Edwards Air Force Base, California, where NASA's Dryden Flight Research Center is located.

  17. Hydroprocessed Esters and Fatty Acids (HEFA) Bio-Based Jet Fuels: Sensory Irritation Study and Human Health Hazard Assessment

    DTIC Science & Technology

    2013-06-30

    AFRL-RH-FS-TR-2014-0001 Hydroprocessed Esters and Fatty Acids (HEFA) Bio -Based Jet Fuels: Sensory Irritation Study and Human Health Hazard...Karen L. Mumy Brian A. Wong R. Arden James James Reboulet Brian Sharits Michael Grimm Nathan Gargas Naval Medical Research Unit - Dayton...Wright-Patterson AFB OH Richard C. Striebich AFRL/RQTF Wright-Patterson AFB OH David R. Mattie Bioeffects Division Molecular Bioeffects Branch

  18. Astronaut Brian Duffy, mission commander for the STS-72 mission, prepares to ascend stairs to the

    NASA Technical Reports Server (NTRS)

    1996-01-01

    STS-72 TRAINING VIEW --- Astronaut Brian Duffy, mission commander for the STS-72 mission, prepares to ascend stairs to the flight deck of the fixed base Shuttle Mission Simulator (SMS) at the Johnson Space Center (JSC). Duffy will be joined by four other NASA astronauts and an international mission specialist aboard the Space Shuttle Endeavour for a scheduled nine-day mission, now set for the winter of this year.

  19. Staged Reading of the Play: Delicate Particle Logic

    NASA Astrophysics Data System (ADS)

    2016-03-01

    The play explores the relationship between science and art through the story of the discovery of nuclear fission. Under the harshly male-dominated science elite of the time, Lise Meitner broke through to become the leader of a major scientific institute, and the first woman to have the title of ``Professor'' in all of Germany. Along with her long-time partner, chemist Otto Hahn, she began a series of experiments that led to the discovery of nuclear fission. The play presents a meeting between Dr. Meitner and Hahn's wife, Edith, who was a painter. The complicated swirl of their intertwined lives, two women and one man, mixes with the violent upheavals in the world, as the Nazis take over Germany and everything changes. The playwright is Jennifer Blackmer who is a faculty member in theatre at Ball State University http://www.jenniferblackmer.com/ and the staged reading is performed by the Pioneer Theatre Company, http://www.pioneertheatre.org/ of Salt Lake City. After the performance, the director and the actors will be available for a talk-back audience discussion. Produced by Brian Schwartz, Brooklyn College and the Graduate Center of the City University of New York.

  20. Executive Function Computerized Training in Very Preterm-Born Children: A Pilot Study.

    PubMed

    Aarnoudse-Moens, Cornelieke S H; Twilhaar, E Sabrina; Oosterlaan, Jaap; van Veen, Heske G; Prins, Pier J M; van Kaam, Anton H L C; van Wassenaer-Leemhuis, Aleid G

    2018-06-01

    Attention problems are one of the most pronounced and documented consequences of very preterm birth (gestational age ≤32 weeks). However, up to now, there is no research published on suitable interventions at school age aimed to overcome these problems. Research in this population did show that executive functions (EFs) are strongly associated with inattention. BrainGame Brian is a newly developed computerized training, in which, in 25 training sessions, the core EFs, including working memory, impulse control, and cognitive flexibility, are trained. This pilot study aimed to examine the feasibility of studying BrainGame Brian in very preterm-born children with attention problems. Pilot feasibility intervention study with one baseline and one follow-up assessment. Feasibility was measured by the participation rate, dropout rate, and user experiences with regard to effort, training characteristics, and recommendation to others. From a larger cohort study, 15 very preterm-born children at age 10 years with parent-reported attention problems on the Child Behavior Checklist/6-18 years were invited to participate in this pilot study. BrainGame Brian was performed for a period of 6 weeks. Training outcome measures included visual working memory, impulse control, cognitive flexibility, speed variability, and parent-rated attention, for which pre- and post-training differences were examined at the group level by the Wilcoxon signed-rank test as well as for each individual child separately by the reliable change index. Twelve of 15 children and their parents agreed to participate and 11 children successfully completed BrainGame Brian in the 6-week period. Parents were positive about training characteristics and lack of interference with schooling, but scored the effort as high. We found clinically significant changes in visual working memory and speed variability in post-training assessments. BrainGame Brian is a feasible intervention for very preterm-born children with attention problems.

  1. The Strategic Defense Initiative. Issues and Implications for the Atlantic Alliance.

    DTIC Science & Technology

    1988-05-01

    Schwartz (Washington, D.C.: The Brookings Institution, 1984), p. 41. 10 Ibid., pp. 41-42. 11 Ibid., pp. 332-333. 12 Barash, p. 142. 13 Brian Green , "The...Initiative. New York: John Wiley and Sons, 1986. Freedman, Lawrence. Arms Control-Management or Reform? Chatham House Papers 31. London: Routledge and Kegan ...Delusions." Policy Review. (Summer 1986) : pp. 48-53. Green , Brian. "The New Case For Civil Defense." The Heritage Foundation Backgrounder. No. 377, August 29

  2. The Caliphates Global Workforce: An Inside Look at the Islamic States Foreign Fighter Paper Trail

    DTIC Science & Technology

    2016-04-01

    The Caliphate’s Global Workforce: An Inside Look at the Islamic State’s Foreign Fighter Paper Trail Brian Dodwell Daniel Milton Don Rassler The...Caliphate’s Global Workforce: An Inside Look at the Islamic State’s Foreign Fighter Paper Trail Brian Dodwell Daniel Milton Don Rassler Combating...Terrorism Center at West Point April 2016 Cover Photo: Image taken from the Islamic State’s Dabiq magazine United States Military Academy www.ctc.usma.edu

  3. Astronauts Brian Duffy and Dan Barry team up to prepare a meal

    NASA Image and Video Library

    1996-01-20

    STS072-306-004 (11-20 Jan. 1996) --- Astronauts Brian Duffy (left), mission commander, and Daniel T. Barry, mission specialist, team up to prepare a meal on the Space Shuttle Endeavour’s middeck. Duffy is also talking to ground controllers during a television tour of the spacecraft. A locker drawer, complete with pre-packaged food is in the foreground, while various smaller packets of food items are attached to nearby locker doors. Orient photo with socked feet at bottom.

  4. Surface Craft Motion Parameter Estimation Using Multipath Delay Measurements from Hydrophones

    DTIC Science & Technology

    2011-12-01

    the sensor is cd . The slant range of the source from the sensor at time t is given by 21222 ])([)( cc RtvtR +−= τ ( 1 ) where 2122 ])[( crtc dhhR...Surface Craft Motion Parameter Estimation Using Multipath Delay Measurements from Hydrophones Kam W. Lo # 1 and Brian G. Ferguson #2 # Maritime...Eveleigh, NSW 2015 Australia 1 kam.lo@dsto.defence.gov.au 2 brian.ferguson@dsto.defence.gov.au Abstract— An equation-error (EE) method is

  5. Competence is My Watchword: An Analysis of the Relationship between Competence and Character in the Army

    DTIC Science & Technology

    2016-06-10

    first is a 2013 Army War College manuscript by Colonel (COL) Brian M. Michelson entitled Character Development of U.S. Army Leaders: A Laissez Faire ...Leaders: A Laissez Faire Approach” (Strategy Research Project, US Army War College, 2013), 19. 21 Ibid., 6-7. 22 Ibid., 20. 23 Ibid., 16. 24...2014. Michelson, Brian M. “Character Development of U.S. Army Leaders: A Laissez Faire Approach.” Strategy Research Project, US Army War College

  6. Immunosuppressive Drug Discontinuation in Noninfectious Uveitis From Real-Life Clinical Practice: A Survival Analysis.

    PubMed

    Abásolo, Lydia; Rosales, Zulema; Díaz-Valle, David; Gómez-Gómez, Alejandro; Peña-Blanco, Rayma C; Prieto-García, Ángela; Benítez-Del-Castillo, José Manuel; Pato, Esperanza; García-Feijoo, Julián; Fernández-Gutiérrez, Benjamín; Rodriguez-Rodriguez, Luis

    2016-09-01

    To assess in uveitis patients the rate of immunosuppressive drug (ISD) discontinuation in real-life clinical practice, comparing this rate among ISDs. Longitudinal retrospective cohort study. We included uveitis patients attending a tertiary eye referral center from Madrid (Spain) between 1989 and 2015, prescribed any ISDs (cyclosporine, methotrexate, azathioprine, anti-TNF drugs, or others). Our main outcome was discontinuation of all ISDs owing to clinical efficacy, inefficacy, adverse drug reaction (ADR), and other medical causes. Discontinuation rates (DRs) per 100 patient-years were estimated. Variables associated with specific-cause discontinuations were analyzed using Cox bivariate and multivariate models. We analyzed 110 patients with 263 treatment courses and 665.2 patient-years of observation. Cyclosporine (66.4%), methotrexate (47.3%), azathioprine (30.9%), and anti-TNFs (30.9%) were the most frequently used ISDs. Treatment was suspended in 136 cases (mostly owing to clinical efficacy [38.2%], inefficacy [26.5%], and ADRs [22.8%]). All-cause DR with 95% confidence interval was 20.4 [17.3-24.2]. Retention rates at 1 and 10 years were 74% and 16%, respectively. In the multivariate analysis, combined treatment exhibited higher DRs owing to clinical efficacy than other ISDs in monotherapy. Conversely, nonbiologic combination therapy with azathioprine exhibited the highest DR owing to ADRs. Clinical efficacy was the most frequent cause for ISD discontinuation, followed by inefficacy and ADRs. DR owing to efficacy was higher for combination therapy. Furthermore, nonbiologic combination therapy with azathioprine was associated with a higher DR owing to ADRs. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Brian hears: online auditory processing using vectorization over channels.

    PubMed

    Fontaine, Bertrand; Goodman, Dan F M; Benichoux, Victor; Brette, Romain

    2011-01-01

    The human cochlea includes about 3000 inner hair cells which filter sounds at frequencies between 20 Hz and 20 kHz. This massively parallel frequency analysis is reflected in models of auditory processing, which are often based on banks of filters. However, existing implementations do not exploit this parallelism. Here we propose algorithms to simulate these models by vectorizing computation over frequency channels, which are implemented in "Brian Hears," a library for the spiking neural network simulator package "Brian." This approach allows us to use high-level programming languages such as Python, because with vectorized operations, the computational cost of interpretation represents a small fraction of the total cost. This makes it possible to define and simulate complex models in a simple way, while all previous implementations were model-specific. In addition, we show that these algorithms can be naturally parallelized using graphics processing units, yielding substantial speed improvements. We demonstrate these algorithms with several state-of-the-art cochlear models, and show that they compare favorably with existing, less flexible, implementations.

  8. Cyclooxygenase-2 Inhibition Enhances Proliferation of NKT Cells Derived from Patients with Laryngeal Cancer.

    PubMed

    Klatka, Janusz; Grywalska, Ewelina; Hymos, Anna; Guz, Małgorzata; Polberg, Krzysztof; Roliński, Jacek; Stepulak, Andrzej

    2017-08-01

    The aim of this study was to analyze whether inhibition of cyclooxygenase-2 by celecoxib and the subsequent enhancement in the proliferation of natural killer T (NKT) cells could play a role in dendritic cell (DC)-based laryngeal cancer (LC) immunotherapy. Peripheral blood mononuclear cells were obtained from 48 male patients diagnosed with LC and 30 control patients without cancer disease. Neoplastic cell lysate preparations were made from cancer tissues obtained after surgery and used for in vitro DCs generation. NKT cells proliferation assay was performed based on 3 H-thymidine incorporation assay. An increased proliferation of NKT cells was obtained from control patients compared to NKT cells obtained from LC patients regardless of the type of stimulation or treatment. In the patient group diagnosed with LC, COX-2 inhibition resulted in a significantly enhanced proliferation of NKT cells when stimulated with autologous DCs than NKT cells stimulated with DCs without COX-2 inhibition. These correlations were not present in the control group. Higher proliferation rate of NKT cells was also observed in non-metastatic and highly differentiated LC, which was independent of the type of stimulation or treatment. COX-2 inhibition could be regarded as immunotherapy-enhancing tool in patients with LC. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  9. PGE2 contributes to TGF-β induced T regulatory cell function in human non-small cell lung cancer

    PubMed Central

    Baratelli, Felicita; Lee, Jay M; Hazra, Saswati; Lin, Ying; Walser, Tonya C; Schaue, Dorthe; Pak, Peter S; Elashoff, David; Reckamp, Karen; Zhang, Ling; Fishbein, Michael C; Sharma, Sherven; Dubinett, Steven M

    2010-01-01

    CD4+CD25bright regulatory T cells (Treg) play an important role in cancer-mediated immunosuppression. We and others have previously shown that prostaglandin E2 (PGE2) and transforming growth factor beta (TGF-β) induce CD4+CD25brightFOXP3+Treg. Based on these studies, we investigated the requirement for PGE2 in Treg induction by TGF-β. TGF-β stimulation of human CD4+ T cells induced COX-2-dependent production of PGE2. PGE2-neutralizing antibody treatment significantly reduced the suppressive function of TGF-β-induced Treg (TGF-β-Treg) in vitro. TGF-β concentration measured in the plasma of non-small cell lung cancer (NSCLC) patients directly correlated with the frequency of circulating CD4+CD25brightFOXP3+T cells. Flow cytometry analysis showed increased FOXP3 expression in circulating CD4+CD25+HLA-DR- cells of lung cancer patients compared to control subjects. Immunohistochemical analysis revealed co-expression of TGF-β, COX-2, and FOXP3 in serial sections from resected lung tumor tissues. All together these observations suggest interplay between TGF-β and COX-2 in the induction of Treg activities. Interrupting TGF-β and PGE2 signaling may be important in therapeutic interventions that aim to limit Tregfunction in lung cancer. PMID:20733946

  10. KENNEDY SPACE CENTER, FLA. - (From left) Brian Duffy, Lockheed Martin vice president/associate program manager, Mildred Carter and Col. (Ret.) Herbert E. Carter, one of the Tuskegee Airmen, attend a dinner sponsored by the KSC Spaceflight and Life Sciences Office. Col. Carter was a guest speaker at the dinner.

    NASA Image and Video Library

    2003-07-18

    KENNEDY SPACE CENTER, FLA. - (From left) Brian Duffy, Lockheed Martin vice president/associate program manager, Mildred Carter and Col. (Ret.) Herbert E. Carter, one of the Tuskegee Airmen, attend a dinner sponsored by the KSC Spaceflight and Life Sciences Office. Col. Carter was a guest speaker at the dinner.

  11. Hugh O'Brian Youth Leadership: Using a Theoretical Model at the Intersection of Youth Leadership Education and Service-Learning.

    PubMed

    Ray, Vicki Ferrence

    2016-06-01

    This chapter presents the Hugh O'Brian Youth Leadership (HOBY) program as a case study, examining their gradual process of shifting all programs to integrate leadership development and service. As an organization with over 4,000 volunteers and a nationwide scope, the change process was a challenge but resulted in benefits that fit the organizations' values. The social change model for leadership development (Higher Education Research Institute, ) was used as a guiding framework. © 2016 Wiley Periodicals, Inc., A Wiley Company.

  12. You are my teachers.

    PubMed

    Edlich, Richard F

    2005-01-01

    Dr. Owen Wangensteen reminded Dr. Edlich that the chief responsibility of a teacher is to create an atmosphere friendly to learning. Dr Wangensteen indicated that the role of professor has been defined as that of teacher, clinician, and investigator. He then indicated that two more responsibilities must be added: (1) sideline cheerleader and (2) regimental water carrier. Above all those enumerated functions, he believed that the most important concern of a professor is to create an atmosphere friendly to learning. He/she must have the willingness to recognize every type of talent and ability and to encourage men/women of promise. He must be the professor of the open door, easily accessible to students, residents, and associates. The major goal of Dr. Edlich's comments, as he receives the Distinguished Medical Alumni Award from The Minneapolis Medical Alumni Association (Minneapolis, Minnesota, USA) is to acknowledge his distinguished colleagues and friends who have served as his teachers during his academic career. They include the following individuals: Theodore J. Edlich, III, President of Total Action Against Poverty; Elizabeth C. Edlic, Cofounder/Chairman and Chief Executive Officer of OneWorldLive; Richard F. Edlich, Jr., President of Edlich Realty; Rachel C. Edlich, Executive Vice President and Cofounder of OneWorldLive; William B. Long, III, MD, President and Medical Director of Trauma Specialists LLP; William P. Magee, MD, Cofounder and Director of Operation Smile; John Barrow, President of Coolibar Incorporated; Mary M. Barrow, Cofounder of Coolibar Incorporated; Kathryne L. Winters, Website Manager and Senior Research Assistant; Lise Borel, DDS, Independent Pharmaceutical/Biotechnical Consultant; Mary Jude Cox, MD, Board Certified Glaucoma Specialist, Teaching Staff at Wills Eye Hospital Glaucoma Service; John Wish, PhD, Member of the Board of The Association of Air Medical Services, Director of the Research Committee; and Dr. Andrew J. Gear, Plastic Surgical Resident, University of Minnesota Medical School.

  13. Brian Hears: Online Auditory Processing Using Vectorization Over Channels

    PubMed Central

    Fontaine, Bertrand; Goodman, Dan F. M.; Benichoux, Victor; Brette, Romain

    2011-01-01

    The human cochlea includes about 3000 inner hair cells which filter sounds at frequencies between 20 Hz and 20 kHz. This massively parallel frequency analysis is reflected in models of auditory processing, which are often based on banks of filters. However, existing implementations do not exploit this parallelism. Here we propose algorithms to simulate these models by vectorizing computation over frequency channels, which are implemented in “Brian Hears,” a library for the spiking neural network simulator package “Brian.” This approach allows us to use high-level programming languages such as Python, because with vectorized operations, the computational cost of interpretation represents a small fraction of the total cost. This makes it possible to define and simulate complex models in a simple way, while all previous implementations were model-specific. In addition, we show that these algorithms can be naturally parallelized using graphics processing units, yielding substantial speed improvements. We demonstrate these algorithms with several state-of-the-art cochlear models, and show that they compare favorably with existing, less flexible, implementations. PMID:21811453

  14. STS-92 - Crew with Dryden Director Kevin Petersen and Deputy Director Wally Saywer

    NASA Image and Video Library

    2000-10-24

    The seven-member crew of the Space Shuttle mission STS-92 gathered in front of the Shuttle Discovery shortly after landing at Edwards Air Force Base in Southern California October 24, 2000. They are seen here with NASA Dryden Fight Research Center Director Kevin Petersen and Deputy Director Wallace Sawyer. From left are mission specialists Koichi Wakata, Michael Lopez-Alegria, Jeff Wisoff, Bill McArthur and Leroy Chiao, pilot Pam Melroy and mission commander Brian Duffy. Between Jeff Wisoff and Brian McArthur are Kevin Petersen and Wally Sawyer, wearing ordinary civilian clothing.

  15. Biological dysrhythm in remitted bipolar I disorder.

    PubMed

    Iyer, Aishwarya; Palaniappan, Pradeep

    2017-12-01

    Recent treatment guidelines support treatment of biological rhythm abnormalities as a part of treatment of bipolar disorder, but still, literature examining various domains (Sleep, Activity, Social, and Eating) of biological rhythm and its clinical predictors are less. The main aim of our study is to compare various domains of biological rhythm among remitted bipolar I subjects and healthy controls. We also explored for any association between clinical variables and biological rhythm among bipolar subjects. 40 subjects with Bipolar I disorder and 40 healthy controls who met inclusion and exclusion criteria were recruited for the study. Diagnoses were ascertained by a qualified psychiatrist using MINI 5.0. Sociodemographic details, biological rhythm (BRIAN-Biological Rhythm Interview of assessment in Neuropsychiatry) and Sleep functioning (PSQI- Pittsburgh Sleep Quality Index) were assessed in all subjects. Mean age of the Bipolar subjects and controls were 41.25±11.84years and 38.25±11.25 years respectively. Bipolar subjects experienced more biological rhythm disturbance when compared to healthy controls (total BRIAN score being 34.25±9.36 vs 28.2±6.53) (p=0.002). Subsyndromal depressive symptoms (HDRS) had significant positive correlation with BRIAN global scores(r=0.368, p=0.02). Linear regression analysis showed that number of episodes which required hospitalization (β=0.601, t=3.106, P=0.004), PSQI (β=0.394, t=2.609, p=0.014), HDRS (β=0.376, t=2.34, t=0.036) explained 31% of variance in BRIAN scores in remitted bipolar subjects. Biological rhythm disturbances seem to persist even after clinical remission of bipolar illness. More studies to look into the impact of subsyndromal depressive symptoms on biological rhythm are needed. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Citizen-Scientist Digitization of a Complex Geologic Map of the McDowell Mountains (Scottsdale, Arizona).

    NASA Astrophysics Data System (ADS)

    Gruber, D.; Skotnicki, S.; Gootee, B.

    2016-12-01

    The work of citizen scientists has become very important to researchers doing field work and internet-based projects but has not been widely utilized in digital mapping. The McDowell Mountains - located in Scottsdale, Arizona, at the edge of the basin-and-range province and protected as part of the McDowell Sonoran Preserve - are geologically complex. Until recently, no comprehensive geologic survey of the entire range had been done. Over the last 9 years geologist Steven Skotnicki spent 2000 hours mapping the complex geology of the range. His work, born of personal interest and partially supported by the McDowell Sonoran Conservancy, resulted in highly detailed hand-drawn survey maps. Dr. Skotnicki's work provides important new information and raises interesting research questions about the geology of this range. Citizen scientists of the McDowell Sonoran Conservancy Field Institute digitized Dr. Skotnicki's maps. A team of 10 volunteers, trained in ArcMap digitization techniques and led by volunteer project leader Daniel Gruber, performed the digitization work. Technical oversight of mapping using ArcMap, including provision of USGS-based mapping toolbars, was provided by Arizona Geological Survey (AZGS) research geologist Brian Gootee. The map digitization process identified and helped resolve a number of mapping questions. The citizen-scientist team spent 900 hours on training, digitization, quality checking, and project coordination with support and review by Skotnicki and Gootee. The resulting digital map has approximately 3000 polygons, 3000 points, and 86 map units with complete metadata and unit descriptions. The finished map is available online through AZGS and can be accessed in the field on mobile devices. User location is shown on the map and metadata can be viewed with a tap. The citizen scientist map digitization team has made this important geologic information available to the public and accessible to other researchers quickly and efficiently.

  17. Affordability of Defense Acquisition Programs

    DTIC Science & Technology

    2015-02-01

    I N S T I T U T E F O R D E F E N S E A N A L Y S E S IDA Paper P-5243 Redacted February 2015 Affordability of Defense Acquisition Programs...Gene H. Porter, Project Leader Kathleen M. Conley C. Vance Gordon R . Royce Kneece, Jr. Brian Q. Rieksts Alan H. Shaw David M. Tate INSTITUTE FOR DEFENSE...Kathleen M. Conley C. Vance Gordon R . Royce Kneece, Jr. Brian Q. Rieksts Alan H. Shaw David M. Tate I N S T I T U T E F O R D E F E N S E A N A L Y S E

  18. PREFACE: Eighth International Conference on Dissociative Recombination (DR2010)

    NASA Astrophysics Data System (ADS)

    Guberman, Steven L.; Orel, Ann E.

    2011-07-01

    In dissociative recombination (DR), a molecular ion captures an electron and falls apart. One might initially conclude that this process is relatively simple. However, a review of the DR literature over the past 60 years, since the pioneering papers of Sir David Bates [1], shows that the study of DR has proved to be highly challenging for both theorists and experimentalists. Both this challenge and the ubiquitous importance of the process have made its study rewarding, endlessly interesting, and full of surprises. DR is fundamentally the interaction of an electronic continuum with a vibrational continuum often connected by quasibound intermediate states. Autoionization in the first continuum competes with dissociation in the second. DR occurs at the total energy of an ion plus a free electron and is in the same region as vibrationally excited Rydberg states and other neutral superexcited states. All these states interact with each other prior to dissociation, forming a complex that controls the quantum yields of products. The complexity of the process has required both innovation and ingenuity on the part of both theorists and experimentalists. Over the years, it has become apparent that in order to compare theoretical and experimental results, the experiments must identify the electronic, vibrational and for low mass ions, the rotational state. The traditional disagreement between theoretical and experimental results has been due, in part, to the sensitivity of DR cross sections and rate constants to the state of the recombining ion. Great progress has been made in recent years in both flowing afterglow and storage ring experiments aimed at reducing this uncertainty. The latest advances and insights in theory and experiment were the topics of the Eighth International Conference on Dissociative Recombination held at the Granlibakken Lodge at Lake, Tahoe, California, 16-20 August 2010. The conference was part of a series of conferences on DR that started at Chateau Lake Louise, Alberta, Canada in May, 1988 [2] and was followed in May 1992 [3] at L'Abbaye de Saint Jacut de la Mer, Brittany, France, in May, 1995 [4] at Ein Gedi, Israel, in June 1999 [5] on the island of Nässlingen in the Stockholm archipelago, Sweden, in August, 2001 [6] at Chicago, USA, in July, 2004 [7] at the Alte Mälzerei, Mosbach, Germany and in July, 2007 [8] at the Resort d'Amelander Kaap on the island of Ameland, The Netherlands. All papers from the last two conferences and this conference are freely available at http://iopscience.iop.org/1742-6596. In keeping with the tradition of prior DR conferences, all papers in this volume have been refereed. Our thanks go to the referees for their efforts. Travel support for conference participants was provided by NSF grant ATM-0838061 and NASA grant NNX09AQ73G to SLG. We thank Priscilla Kujawski for proofreading the Dedication. Steven L GubermanAnn E OrelEditors Conference photograph Participants of the 8th International Conference on Dissociative Recombination: Theory, Experiments and Applications. 1. Stephen Pratt18. Randy Vane35. Robert Continetti 2. Chris Greene19. Claude Krantz36. Henrik Buhr 3. Bastiaan Braams20. Xavier Urbain37. Mats Larsson 4. Ed Grant21. Hidekazu Takagi38. Dirk Schwalm 5. Christian Nordhorn22. Brian Mitchell39. Evelyne Roueff 6. Steen Brønsted Nielsen23. Andreas Wolf40. Pascal Pernot 7. Dermot Madden24. Daren Stotler41. Stefan Rosén 8. Radek Plašil25. Slava Kokoouline42. Rainer Johnsen 9. Daniel Savin26. David Schultz43. Xiaohong Cai 10. Jonathan Tennyson27. Mourad Telmini44. Dan Haxton 11. Peet Hickman28. Ruth Malenda45. Åsa Larson 12. Michael Fogle29. Slim Chourou46. Dahbia Talbi 13. Waffeu Tamo Francois Oliver30. Petr Dohnal47. Ann Orel 14. Christian Jungen31. Julia Stützel48. Steven Guberman 15. Ilya Fabrikant32. Ioan Schneider49. Jane Fox 16. Wolf Geppert33. Nicholas Shuman50. Richard Thomas 17. Oldřich Novotný34. Holger Kreckel51. Fangfang Ruan

  19. Resveratrol protects from lipopolysaccharide-induced inflammation in the uterus and prevents experimental preterm birth.

    PubMed

    Bariani, María Victoria; Correa, Fernando; Leishman, Emma; Domínguez Rubio, Ana Paula; Arias, Andreína; Stern, Aníbal; Bradshaw, Heather B; Franchi, Ana María

    2017-08-01

    Is resveratrol able to prevent the lipopolysaccharide (LPS)-induced preterm labor in 15-day pregnant BALB/c mice? Resveratrol prevented the LPS-induced onset of preterm labor in 64% of the cases and showed anti-inflammatory and tocolytic effects by downregulating COX-2 and iNOS expression and NOS activity, and by changing the uterine prostaglandin and endocannabinoid profiling. Genital tract infections by Gram-negative bacteria are a common complication in human pregnancy and have been shown to increase risk of preterm delivery. Bacterial LPS elicits a strong maternal inflammatory response that results in preterm delivery and fetal death in a murine model endotoxin-induced preterm labor. An in vivo animal study was conducted. On Day 15 of pregnancy, mice received at 8:00 h a dose of vehicle (40% ethanol in saline solution) or resveratrol (3 mg/kg in vehicle) via oral gavage followed by two doses of LPS or vehicle administered intraperitoneally (i.p.), the first one at 10:00 h (0.17 mg/kg in 0.1 ml of sterile saline solution) and the second at 13:00 h (0.5 mg/kg in 0.1 ml of sterile saline solution). The mice were closely observed for any signs of morbidity (piloerection, decreased movement, and diarrhea), vaginal bleeding or preterm delivery. The beginning of preterm delivery was defined by early delivery of the first pup. Normal term labor occurs on Day 19 of gestation. Time of labor, pregnancy outcome and morphological features were evaluated after LPS and/or resveratrol administration. Uterine stripes were collected 5 h after the last LPS injection and prostaglandin and endocannabinoid profiling was analyzed by mass spectrometry. Nitric oxide synthase (NOS) activity was measured by radioconversion assay. Cyclooxygenase-2 (Cox-2) and 15-hydroxyprostaglandin dehydrogenase (15-Pgdh) mRNA levels were analyzed by RT-PCR whilst the protein expression of inducible nitric oxide synthase (iNOS), COX-1 and COX-2 were studied by western blot. In vivo treatment of 15-day pregnant BALB/c mice with resveratrol prevented the LPS-induced preterm birth in 64% of the cases, whereas only 15% of mice with LPS alone escaped preterm birth. Treatment with resveratrol resulted in a reduced NOS activity (P < 0.05) in the uterus of LPS-treated mice. Similarly, resveratrol reduced the expression of LPS-induced pro-inflammatory agents such as iNOS (P < 0.05), COX-2 (P < 0.05), prostaglandin E2 (PGE2) (P < 0.05) and anandamide (AEA) (P < 0.05). Moreover, resveratrol administration resulted in changes in the uterine endocannabinoid profiling altered by LPS. N/A. Since our experimental design involves the use of mice, the extrapolation of the results presented here to humans is limited. Our findings provide evidence for the tocolytic effects of resveratrol. Dr Ana María Franchi was funded by Agencia Nacional para la Promoción Científica y Tecnológica (PICT 2013/0097) and by Consejo Nacional de Investigaciones Científicas y Técnicas (PIP 2012/0061). Dr Heather B. Bradshaw was funded by NIH (DA006668). The authors have no competing interests. © The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  20. STS-92 crew takes part in a Leak Seal Kit Fit Check in the SSPF

    NASA Technical Reports Server (NTRS)

    1999-01-01

    STS-92 crew members discuss results of a Leak Seal Kit Fit Check on the Pressurized Mating Adapter -3, part of their mission payload, with JSC and Boeing representatives. From left are Mission Specialists Michael E. Lopez-Alegria; Koichi Wakata, who represents the National Space Development Agency of Japan (NASDA); (standing) Peter J.K. 'Jeff' Wisoff (Ph.D.) and William Surles 'Bill' McArthur Jr.; (seated) Pilot Pamela A. Melroy; Dave Moore (behind Melroy), with Boeing; Mission Specialist Leroy Chiao (Ph.D.); Brian Warkentine, with JSC; and Commander Brian Duffy. The mission payload also includes an integrated truss structure (Z-1 truss). Launch of STS-92 is scheduled for Feb. 24, 2000.

  1. The Brian Simulator

    PubMed Central

    Goodman, Dan F. M.; Brette, Romain

    2009-01-01

    “Brian” is a simulator for spiking neural networks (http://www.briansimulator.org). The focus is on making the writing of simulation code as quick and easy as possible for the user, and on flexibility: new and non-standard models are no more difficult to define than standard ones. This allows scientists to spend more time on the details of their models, and less on their implementation. Neuron models are defined by writing differential equations in standard mathematical notation, facilitating scientific communication. Brian is written in the Python programming language, and uses vector-based computation to allow for efficient simulations. It is particularly useful for neuroscientific modelling at the systems level, and for teaching computational neuroscience. PMID:20011141

  2. The effect of different immunoprophylaxis regimens on post-transplant cytomegalovirus (CMV) infection in CMV-seropositive liver transplant recipients.

    PubMed

    Low, Chian Yong; Hosseini-Moghaddam, Seyed Mohammadmehdi; Rotstein, Coleman; Renner, Eberhard L; Husain, Shahid

    2017-10-01

    The effects of different immunoprophylaxis regimens on cytomegalovirus (CMV) infection in liver transplant recipients (LTRs) have not been compared. In a cohort, we studied 343 CMV-seropositive recipient (R+) and 83 seronegative donor/recipient (D-/R-) consecutive LTRs from 2004 to 2007. Immunoprophylaxis regimens included steroid-only, steroids plus rabbit anti-thymocyte globulin (rATG), and steroids plus basiliximab. Logistic regression analysis, Cox proportional hazards regression model, and log-rank test were performed for multivariate analysis as appropriate. In total, 164 (39%), 69 (16%), and 193 (45%) patients received steroid-only, basiliximab, and rATG immunoprophylaxis, respectively. CMV infection rates were 15.7% (54/343) in CMV R+ LTRs and 2.4% (2/83) in CMV R- LTRs. Among CMV R+ LTRs who received rATG, the use of at least 6 weeks of CMV prophylaxis reduced the rate of CMV infection from 24.4% (19/78) to 11.7% (9/77). In multivariate analysis, CMV R+ vs D-/R- (odds ratio [OR]=13.1, 95% confidence interval [CI]: 1.8-97.2), rATG >3 mg/kg vs steroid-only induction (OR=1.6, 95% CI: 1.1-2.3), and CMV prophylaxis <6 weeks vs ≥6 weeks (OR=2.7, 95% CI: 1.2-6.4) were independently associated with CMV infection. Subgroup analysis in CMV D-/R+ group who received rATG showed that ≥6 weeks of CMV prophylaxis significantly decreased the risk of CMV infection (OR=1.9, 95% CI: 1.1-3.9; P=.03). The use of rATG immunoprophylaxis increases the risk of CMV infection in CMV-seropositive LTRs, specifically in the CMV D-/R+ group. Prophylaxis with valganciclovir in this group for at least 6 weeks decreases the risk of CMV infection. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: a TransATAC study.

    PubMed

    Dowsett, Mitch; Cuzick, Jack; Wale, Christopher; Forbes, John; Mallon, Elizabeth A; Salter, Janine; Quinn, Emma; Dunbier, Anita; Baum, Michael; Buzdar, Aman; Howell, Anthony; Bugarini, Roberto; Baehner, Frederick L; Shak, Steven

    2010-04-10

    PURPOSE To determine whether the Recurrence Score (RS) provided independent information on risk of distant recurrence (DR) in the tamoxifen and anastrozole arms of the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Trial. PATIENTS AND METHODS RNA was extracted from 1,372 tumor blocks from postmenopausal patients with hormone receptor-positive primary breast cancer in the monotherapy arms of ATAC. Twenty-one genes were assessed by quantitative reverse transcriptase polymerase chain reaction, and the RS was calculated. Cox proportional hazards models assessed the value of adding RS to a model with clinical variables (age, tumor size, grade, and treatment) in node-negative (N0) and node-positive (N+) women. RESULTS Reportable scores were available from 1,231 evaluable patients (N0, n = 872; N+, n = 306; and node status unknown, n = 53); 72, 74, and six DRs occurred in N0, N+, and node status unknown patients, respectively. For both N0 and N+ patients, RS was significantly associated with time to DR in multivariate analyses (P < .001 for N0 and P = .002 for N+). RS also showed significant prognostic value beyond that provided by Adjuvant! Online (P < .001). Nine-year DR rates in low (RS < 18), intermediate (RS = 18 to 30), and high RS (RS > or = 31) groups were 4%, 12%, and 25%, respectively, in N0 patients and 17%, 28%, and 49%, respectively, in N+ patients. The prognostic value of RS was similar in anastrozole- and tamoxifen-treated patients. CONCLUSION This study confirmed the performance of RS in postmenopausal HR+ patients treated with tamoxifen in a large contemporary population and demonstrated that RS is an independent predictor of DR in N0 and N+ hormone receptor-positive patients treated with anastrozole, adding value to estimates with standard clinicopathologic features.

  4. Analysis of the Influence of HLA-A Matching Relative to HLA-B and -DR Matching on Heart Transplant Outcomes

    PubMed Central

    Ansari, David; Bućin, Dragan; Höglund, Peter; Ohlsson, Mattias; Andersson, Bodil; Nilsson, Johan

    2015-01-01

    Background There are conflicting reports on the effect of donor-recipient HLA matching on outcomes in heart transplantation. The objective of this study was to investigate the effects of HLA-A matching relative to HLA-B and -DR matching on long-term survival in heart transplantation. Methods A total of 25 583 patients transplanted between 1988 and 2011 were identified from the International Society for Heart and Lung Transplantation registry. Transplants were divided into 2 donor-recipient matching groups: HLA-A–compatible (no HLA-A mismatches) and HLA-A–incompatible (1-2 HLA-A mismatches). Primary outcome was all-cause mortality. Secondary outcomes were graft failure-, cardiovascular-, infection-, or malignancy-related deaths. Results The risk of all-cause mortality 15 years after transplantation was higher for HLA-A–compatible (vs HLA-A–incompatible) grafts in patients who had HLA-B–, HLA-DR–, or HLA-B,DR–incompatible grafts (P = 0.027, P = 0.007, and P = 0.002, respectively) but not in HLA-B– and/or HLA-DR–compatible grafts. This was confirmed in multivariable Cox regression analysis where HLA-A compatibility (vs HLA-A incompatibility) was associated with higher mortality in transplants incompatible for HLA-DR or HLA-B and -DR (hazard ratio [HR], 1.59; 95% confidence interval [95% CI], 1.11-2.28; P = 0.012 and HR, 1.69; 95% CI, 1.17-2.43; P = 0.005, respectively). In multivariable analysis, the largest compromise in survival for HLA-A compatibility (vs HLA-incompatibility) was for chronic rejection in HLA-B– and -DR–incompatible grafts (HR, 1.91; 95% CI, 1.22-3.01; P = 0.005). Conclusions Decreased long-term survival in heart transplantation was associated with HLA-A compatibility in HLA-B,DR–incompatible grafts. PMID:27500238

  5. SPS Fabric of the Cosmos Cafe

    NASA Astrophysics Data System (ADS)

    Chakrabarti, Anish

    2012-02-01

    Hosted by Brian Greene and based on his best-selling book of the same title, The Fabric of the Cosmos is a new four- part NOVA series that explores the deepest mysteries of space and time. The program was kicked-off by 30 ``Cosmic Cafes'' being held around the country funded by an NSF grant which allows SPS-NOVA to fund SPS chapters for these events. During the summer I assisted in planning this kick-off, reviewing and suggesting revisions of resources related to the NOVA series to make them relevant to an SPS audience. I also got to organize and moderate the first ``Cosmic Cafe.'' The Cosmic cafe that I organized was discussion based, with our speaker Dr. James Gates starting with a short talk and then opening the floor up for questions. By organizing a ``Cosmic cafe,'' I got real hand experience about the challenges an SPS chapter would face while organizing a cafe themselves. Based on my experience I shall also discuss the effectiveness of the first ever themed science cafe blitz. A science caf'e is an informal discussion with an expert in a very casual location, usually a restaurant, coffee shop, or a bar. A science cafe is mostly discussion based, but has a lot of freedom for the format. A ``Cosmic'' cafe is a science cafe which is based around the topics discussed in the documentary ``The Fabric of the Cosmos.''

  6. SPS 'Fabric of the Cosmos' Science Cafés

    NASA Astrophysics Data System (ADS)

    Chakrabarti, A.

    2011-12-01

    Hosted by Brian Greene and based on his best selling book of the same title, The Fabric of the Cosmos is a new four part NOVA series that explores the deepest mysteries of space and time. The program was kicked off by more than 30 'Cosmic Cafes' around the country, as part of a Society of Physics Students, NOVA outreach effort funded by an NSF grant. A Cosmic Café is a science café based on the topics discussed in The Fabric of the Cosmos. Science cafes are open events for non-scientists, where they can have an informal discussion with a scientist in a very casual location, usually a restaurant, coffee shop, or a bar. During the summer I assisted in planning this kick off, by reviewing science café and The Fabric of the Cosmos resources and suggesting revisions to make them more relevant for an SPS audience. I also organized and moderated the first Cosmic Café. The café that I organized was discussion based, with the speaker, Dr. James Gates, starting with a short talk and then opening up the floor for questions. Organizing a Cosmic Café gave me first-hand experience with the challenges an SPS chapter might face while organizing a café themselves. I will discuss lessons learned and the effectiveness of the first ever themed science café blitz.

  7. STS-92 crew takes part in a Leak Seal Kit Fit Check in the SSPF

    NASA Technical Reports Server (NTRS)

    1999-01-01

    In the Space Station Processing Facility, STS-92 crew members take part in a Leak Seal Kit Fit Check in connection with the Pressurized Mating Adapter -3 in the background. From left are Mission Specialist Peter J.K. 'Jeff' Wisoff (Ph.D.), Pilot Pamela A. Melroy, Commander Brian Duffy, Mission Specialist Koichi Wakata, who represents the National Space Development Agency of Japan (NASDA), Brian Warkentine, with JSC, and a Boeing worker at right. Also participating are other crew members Mission Specialists Leroy Chiao (Ph.D.), Michael E. Lopez-Alegria and William Surles 'Bill' McArthur Jr. The mission payload also includes an integrated truss structure (Z-1 truss). Launch of STS-92 is scheduled for Feb. 24, 2000.

  8. Brian Fluegel | NREL

    Science.gov Websites

    ordering. In addition, he became responsible for the continued upgrading of the laser and detection system nitride alloys and hybrid organic-inorganic semiconductors. Featured Publications View all NREL

  9. Summer Reading

    NASA Astrophysics Data System (ADS)

    Pagni, Dick; Frech, Cheryl; Coppola, Brian; Kovac, Jeffrey; Harris, Hal

    2007-06-01

    Summer, a great time for leisure reading, a great time to try something different! Dick Pagni, Cheryl Frech, Brian Coppola, Jeffrey Kovac, and Hal Harris provide plenty of suggestions to keep you reading!

  10. HLA-A, -B, and -DR zero-mismatched kidneys shipped to the University of Wisconsin, Madison, 1993-2006: superior graft survival despite longer preservation time.

    PubMed

    Burlingham, William J; Muñoz del Rio, Alejandro; Lorentzen, David; Sollinger, Hans W; Pirsch, John D; Jankowska-Gan, Ewa; D'Alessandro, Anthony

    2010-08-15

    To determine the impact at a single center of the United Network for Organ Sharing-mandated sharing program for human leukocyte antigen (HLA)-A/-B/-DR 0-mismatched (0MM) kidneys, we analyzed the results of 264 kidney transplants from 0MM distant donors between 1993 and 2006, with a follow-up through January 31, 2007. We compared these results with that of concurrent kidneys transplanted from HLA more than 0MM local donors and with shipped more than 0MM kidneys from "payback" donors. Despite a significantly longer preservation time, we found an 11% increase in 8-year graft survival (63% vs. 52%; P<0.003) of 0MM shipped versus locally procured, >0MM donor kidneys. Graft survival of 0MM shipped kidneys at 8 years was significantly better in nonsensitized (<20% panel reactive antibodies; 68% vs. 55%; P<0.0005) but not in sensitized (>or=20% panel reactive antibodies) recipients, who showed an early (2 years) but short-lived benefit. The benefit of receiving a HLA-A, -B, and -DR 0MM shipped kidney remained strong and statistically significant (0.71 relative risk of graft loss vs. local; P<0.02) when adjusted for 22 potentially confounding variables in a Cox proportional hazards analysis. The recent change in United Network for Organ Sharing policy restricting mandated sharing of 0MM kidneys to sensitized and pediatric recipients will give greater flexibility to the local organ procurement organization in allocating organs. However, the survival benefit to nonsensitized patients is real and long lasting and will be lost.

  11. Brian Ball | NREL

    Science.gov Websites

    Integration program, developing inverse modeling algorithms to calibrate building energy models, and is part related equipment. This work included developing an engineering grade operator training simulator for an

  12. Wired for Mathematics: A Conversation with Brian Butterworth.

    ERIC Educational Resources Information Center

    D'Arcangelo, Marcia

    2001-01-01

    Interview with neuropsychologist Brain Butterworth about what research has revealed about how the brain learns abstract concepts such as mathematics and the implications of these findings for teaching mathematics. (PKP)

  13. Summer Reading

    NASA Astrophysics Data System (ADS)

    Harris, Harold H.; Pagni, Richard M.; Kovac, Jeffrey; Coppola, Brian P.

    2003-06-01

    Summer, a great time for leisure reading! Try to set aside some time and find a quiet spot, because Hal Harris, Dick Pagni, Jeff Kovac, and Brian Coppola have a variety of interesting suggestions for you.

  14. Summer Reading

    NASA Astrophysics Data System (ADS)

    Pagni, Richard M.; Baldwin Frech, Cheryl; Coppola, Brian P.; Harris, Harold H.; Kovac, Jeffrey

    2005-06-01

    Summer, a great time for leisure reading, a great time to try something different! Cheryl Baldwin Frech joins regulars Dick Pagni, Brian Coppola, Hal Harris, and Jeff Kovac in providing plenty of suggestions to tempt you.

  15. Application of Compressive Sensing to Digital Holography

    DTIC Science & Technology

    2015-05-01

    WITH ASSIGNED DISTRIBUTION STATEMENT. // Signature// // Signature// DAVID J. RABB BRIAN D. EWERT, Chief Program Manager...Signature// TRACY W. JOHNSTON, Chief Multispectral Sensing and Detection Division Sensors Directorate This report is published in

  16. Piloted, Electric Propulsion-Powered Experimental Aircraft Underway

    NASA Image and Video Library

    2015-04-30

    Team members of the Leading Edge Asynchronous Propeller Technology Ground Test team include from left Brian Soukup, Sean Clarke, Douglas Howe, Dena Gruca, Kurt Papathakis, Jason Denman, Vincent Bayne and Freddie Graham.

  17. Learning in the third dimension.

    PubMed

    Boyd, Sharon; Clarkson, Eoghan; Mather, Brian

    2015-04-04

    Sharon Boyd, Eoghan Clarkson and Brian Mather explain how the Royal (Dick) School of Veterinary Studies is using the latest 3D modelling techniques to help students develop their clinical skills. British Veterinary Association.

  18. Ageing, exposure to pollution, and interactions between climate change and local seasons as oxidant conditions predicting incident hematologic malignancy at KINSHASA University clinics, Democratic Republic of CONGO (DRC).

    PubMed

    Nkanga, Mireille Solange Nganga; Longo-Mbenza, Benjamin; Adeniyi, Oladele Vincent; Ngwidiwo, Jacques Bikaula; Katawandja, Antoine Lufimbo; Kazadi, Paul Roger Beia; Nzonzila, Alain Nganga

    2017-08-23

    The global burden of hematologic malignancy (HM) is rapidly rising with aging, exposure to polluted environments, and global and local climate variability all being well-established conditions of oxidative stress. However, there is currently no information on the extent and predictors of HM at Kinshasa University Clinics (KUC), DR Congo (DRC). This study evaluated the impact of bio-clinical factors, exposure to polluted environments, and interactions between global climate changes (EL Nino and La Nina) and local climate (dry and rainy seasons) on the incidence of HM. This hospital-based prospective cohort study was conducted at Kinshasa University Clinics in DR Congo. A total of 105 black African adult patients with anaemia between 2009 and 2016 were included. HM was confirmed by morphological typing according to the French-American-British (FAB) Classification System. Gender, age, exposure to traffic pollution and garages/stations, global climate variability (El Nino and La Nina), and local climate (dry and rainy seasons) were potential independent variables to predict incident HM using Cox regression analysis and Kaplan Meier curves. Out of the total 105 patients, 63 experienced incident HM, with an incidence rate of 60%. After adjusting for gender, HIV/AIDS, and other bio-clinical factors, the most significant independent predictors of HM were age ≥ 55 years (HR = 2.4; 95% CI 1.4-4.3; P = 0.003), exposure to pollution and garages or stations (HR = 4.9; 95% CI 2-12.1; P < 0.001), combined local dry season + La Nina (HR = 4.6; 95%CI 1.8-11.8; P < 0.001), and combined local dry season + El Nino (HR = 4; 95% CI 1.6-9.7; P = 0.004). HM types included acute myeloid leukaemia (28.6% n = 18), multiple myeloma (22.2% n = 14), myelodysplastic syndromes (15.9% n = 10), chronic myeloid leukaemia (15.9% n = 10), chronic lymphoid leukaemia (9.5% n = 6), and acute lymphoid leukaemia (7.9% n = 5). After adjusting for confounders using Cox regression analysis, age ≥ 55 years, exposure to pollution, combined local dry season + La Nina and combined local dry season + El Nino were the most significant predictors of incident hematologic malignancy. These findings highlight the importance of aging, pollution, the dry season, El Nino and La Nina as related to global warming as determinants of hematologic malignancies among African patients from Kinshasa, DR Congo. Cancer registries in DRC and other African countries will provide more robust database for future researches on haematological malignancies in the region.

  19. Flood Lites: Resources for Gifted and Talented Children and Youth.

    ERIC Educational Resources Information Center

    Flood, Dennis

    1992-01-01

    Two educational resources for use with gifted students are evaluated. Positively rated are "The Gifted Evaluation Scale" (Stephen B. Carney) and "The Psychology of Achievement" (audiotape series by Brian Tracy). (DB)

  20. 77 FR 12331 - Membership of National Science Foundation's Senior Executive Service Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... Management, and Chief Financial Officer. Brian W. Stone, Director, Antarctic Infrastructure and Logistics... Resource Management and Chief Human Capital Officer. Deborah F. Lockhart, Deputy Director, Division of...

  1. Letter from Charles Jordon, Hercules, Inc., to Brian Young, MDEQ

    EPA Pesticide Factsheets

    Cover letter dated July 31, 1997 from Hercules, Inc. in Hattiesburg, Mississippi to Mississippi Department of Environmental Quality and an attached work plan for the installation of six monitoring wells.

  2. Summer Reading

    NASA Astrophysics Data System (ADS)

    Harris, Harold H.; Kovac, Jeffrey; Pagni, Richard M.; Coppola, Brian P.

    2004-06-01

    Summer, a great time for leisure reading! Try to set aside some time and find a quiet spot, because once again Hal Harris, Dick Pagni, Jeff Kovac, and Brian Coppola have a variety of interesting suggestions for you.

  3. STS-92 Commander Brian Duffy suits up for launch

    NASA Technical Reports Server (NTRS)

    2000-01-01

    In the Operations and Checkout Building, STS-92 Commander Brian Duffy solemnly undergoes suit check before heading out to the Astrovan for the ride to Launch Pad 39A. During the 11-day mission to the International Space Station, four extravehicular activities (EVAs), or spacewalks, are planned for construction. The payload includes the Integrated Truss Structure Z-1 and the third Pressurized Mating Adapter. The Z-1 truss is the first of 10 that will become the backbone of the Space Station, eventually stretching the length of a football field. PMA-3 will provide a Shuttle docking port for solar array installation on the sixth Station flight and Lab installation on the seventh Station flight. Launch is scheduled for 7:17 p.m. EDT. Landing is expected Oct. 22 at 2:10 p.m. EDT.

  4. Development of a Self-Consistent Model of Plutonium Sorption: Quantification of Sorption Enthalpy and Ligand-Promoted Dissolution

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Powell, Brian; Kaplan, Daniel I; Arai, Yuji

    2016-12-29

    This university lead SBR project is a collaboration lead by Dr. Brian Powell (Clemson University) with co-principal investigators Dan Kaplan (Savannah River National Laboratory), Yuji Arai (presently at the University of Illinois), Udo Becker (U of Michigan) and Rod Ewing (presently at Stanford University). Hypothesis: The underlying hypothesis of this work is that strong interactions of plutonium with mineral surfaces are due to formation of inner sphere complexes with a limited number of high-energy surface sites, which results in sorption hysteresis where Pu(IV) is the predominant sorbed oxidation state. The energetic favorability of the Pu(IV) surface complex is strongly influencedmore » by positive sorption entropies, which are mechanistically driven by displacement of solvating water molecules from the actinide and mineral surface during sorption. Objectives: The overarching objective of this work is to examine Pu(IV) and Pu(V) sorption to pure metal (oxyhydr)oxide minerals and sediments using variable temperature batch sorption, X-ray absorption spectroscopy, electron microscopy, and quantum-mechanical and empirical-potential calculations. The data will be compiled into a self-consistent surface complexation model. The novelty of this effort lies largely in the manner the information from these measurements and calculations will be combined into a model that will be used to evaluate the thermodynamics of plutonium sorption reactions as well as predict sorption of plutonium to sediments from DOE sites using a component additivity approach.« less

  5. 78 FR 22529 - Notice of Availability of Government-Owned Inventions; Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

    .... 101875: INERTIAL SENSORS USING SLIDING PLANE ELECTRON TUNNELING PROXIMITY SWITCHES//Navy Case No. 102181... TRIGGER FOR USE IN TIME-DOMAIN MEMS INERTIAL SENSORS. FOR FURTHER INFORMATION CONTACT: Brian Suh, Office...

  6. Susan Parker Bodine, Letter to Brian Jennings of American Coalition for Ethanol, November 7, 2006

    EPA Pesticide Factsheets

    This letter responds to correspondence concerning the applicability of EPA's Facility Response Plan (FRP) regulations to ethanol production and storage facilities and whether denatured ethanol is an oil.

  7. 76 FR 63922 - Environmental Impacts Statements; Notice of Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... City Charlotte to I-485 near the Mecklenburg-Cabarrus County Line, Charlotte-Mecklenburg County, NC, Review Period Ends: 11/ 14/2011, Contact: Brian C. Smart 404-865-5607. EIS No. 20110342, Draft Supplement...

  8. Culture.

    ERIC Educational Resources Information Center

    1997

    Twelve conference papers on cultural aspects of second language instruction include: "Towards True Multiculturalism: Ideas for Teachers" (Brian McVeigh); Comparing Cultures Through Critical Thinking: Development and Interpretations of Meaningful Observations" (Laurel D. Kamada); "Authority and Individualism in Japan and the…

  9. Summer Reading

    NASA Astrophysics Data System (ADS)

    Kovac, Jeffrey; Pagni, Richard M.; Harris, Harold H.; Coppola, Brian P.

    2002-06-01

    Ah, summer approaches! Perhaps you will find some time for leisure reading. With this hope in mind, here are a few suggestions that Jeff Kovac, our Book & Media Reviews Editor, has assembled with the help of Dick Pagni, Hal Harris, and Brian Coppola.

  10. Summer Reading

    NASA Astrophysics Data System (ADS)

    Kovac, Jeffrey; Pagni, Richard; Harris, Harold H.; Coppola, Brian P.

    2001-06-01

    Ah, summer approaches! Perhaps you will find some time for leisure reading. With this hope in mind, here are a few suggestions that Jeff Kovac, our Book & Media Reviews Editor, has assembled with the help of Dick Pagni, Hal Harris, and Brian Coppola.

  11. 77 FR 31355 - Environmental Impacts Statements; Notice of Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ...: https://cdx.epa.gov . EIS No. 20120157, Final EIS, FTA, GA, Tier 1--Atlanta Beltline City of Atlanta..., Review Period Ends: 06/ 25/2012, Contact: Brian Smart 404-865-5600. EIS No. 20120158, Draft EIS, USACE...

  12. Pre-Alpine (Variscan) Inheritance: A Key for the Location of the Future Valaisan Basin (Western Alps)

    NASA Astrophysics Data System (ADS)

    Ballèvre, M.; Manzotti, P.; Dal Piaz, G. V.

    2018-03-01

    The boundary between the Helvetic and the Penninic (=Briançonnais) Zones has long been recognized as a major fault ("Penninic Front") in the Western Alps. A narrow oceanic domain has been postulated at least along part of this boundary (the Valaisan Basin). However, the information provided by the pre-Triassic basement has not been fully exploited and will be discussed here in detail. The igneous and metamorphic history of the pre-Triassic basement shows significant differences between the External Massifs from the Helvetic Zone, with abundant Late Carboniferous granites, and the basement of the Briançonnais Zone, including the Internal Massifs (Dora-Maira, Gran Paradiso, and Monte Rosa), devoid of Carboniferous granites. A major coal-bearing basin, the "Zone Houillère," opened along this boundary. This limnic intramontane basin has never been properly investigated. The Zone Houillère is not comparable with the external, paralic, flexural, basins on both sides of the Variscan belt but shows similarities with the Saar-Saale Basin. Like the latter, we interpret the Zone Houillère as a transtensional basin opened along a major, crustal-scale, fault zone, namely, the East Variscan Shear Zone. The Permian magmatism and sedimentation displays contrasting distributions, being absent or very localized in the Helvetic Zone, and widespread in the Penninic Zone. The above data indicate that the structural inheritance from the Variscan belt plays a major role in defining the future location of the Valaisan Basin, that is, the boundary between the European paleomargin and the Briançonnais microcontinent.

  13. 78 FR 65978 - Application To Export Electric Energy; Powerex Corp.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... above, by accessing the program Web site at http://energy.gov/node/11845 , or by emailing Angela Troy at hq.doe.gov ">Angela.Troy@ hq.doe.gov . Issued in Washington, DC, on October 29, 2013. Brian Mills...

  14. Grammar! A Conference Report.

    ERIC Educational Resources Information Center

    King, Lid, Ed.; Boaks, Peter, Ed.

    Papers from a conference on the teaching of grammar, particularly in second language instruction, include: "Grammar: Acquisition and Use" (Richard Johnstone); "Grammar and Communication" (Brian Page); "Linguistic Progression and Increasing Independence" (Bernardette Holmes); "La grammaire? C'est du bricolage!" ("Grammar? That's Hardware!") (Barry…

  15. House NASA FY 19' Budget Hearing

    NASA Image and Video Library

    2018-03-07

    House Subcommittee on Space Chairman Rep. Brian Babin, R-Texas, is seen during a hearing overview of the NASA Budget for Fiscal Year 2019, Wednesday, March 7, 2018, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

  16. 75 FR 56080 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Notice AGENCY: Defense Nuclear Facilities... Facilities Safety Board's public hearing and meeting. FEDERAL REGISTER CITATION OF PREVIOUS ANNOUNCEMENT: 75... INFORMATION: Brian Grosner, General Manager, Defense Nuclear Facilities Safety Board, 625 Indiana Avenue, NW...

  17. Nurses hold the key to purchasing reforms in the NHS.

    PubMed

    Canning, S

    1994-07-13

    JUST over a year ago health minster Brian Mawhinney, speaking to the Royal College of Physicians, sowed a seed which could eventually lead to the nation's nurses branching out and playing the lead role in health care purchasing.

  18. CUHK Papers in Linguistics, Number 4.

    ERIC Educational Resources Information Center

    Tang, Gladys, Ed.

    1993-01-01

    Papers in this issue include the following: "Code-Mixing in Hongkong Cantonese-English Bilinguals: Constraints and Processes" (Brian Chan Hok-shing); "Information on Quantifiers and Argument Structure in English Learner's Dictionaries" (Thomas Hun-tak Lee); "Systematic Variability: In Search of a Linguistic…

  19. 77 FR 39678 - Census Bureau

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... Current Population Survey Annual Social and Economic Supplement Content Test AGENCY: U.S. Census Bureau...) and instructions should be directed to Brian O'Hara, Social and Economic Housing Statistics Division... INFORMATION: I. Abstract The Current Population Survey (CPS) Annual Social and Economic [[Page 39679...

  20. Defense.gov - Special Report: Travels with Mullen

    Science.gov Websites

    , 2010 Top Stories Mullen, USO Performers Thank Troops KUWAIT CITY, Kuwait, April 1, 2010 – U.S. Navy Sirico and Rose McGowan, and Brian Stinchcomb of the New Orleans Saints on a USO sponsored tour of

  1. 75 FR 70214 - Renewable Energy and Energy Efficiency Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... DEPARTMENT OF COMMERCE International Trade Administration Renewable Energy and Energy Efficiency... of an open meeting. SUMMARY: The Renewable Energy and Energy Efficiency Advisory Committee (RE&EEAC... INFORMATION CONTACT: Brian O'Hanlon, Office of Energy and Environmental Technologies Industries (OEEI...

  2. Postoperative Stereotactic Radiosurgery Without Whole-Brain Radiation Therapy for Brain Metastases: Potential Role of Preoperative Tumor Size

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hartford, Alan C., E-mail: Alan.C.Hartford@Hitchcock.org; Paravati, Anthony J.; Spire, William J.

    2013-03-01

    Purpose: Radiation therapy following resection of a brain metastasis increases the probability of disease control at the surgical site. We analyzed our experience with postoperative stereotactic radiosurgery (SRS) as an alternative to whole-brain radiotherapy (WBRT), with an emphasis on identifying factors that might predict intracranial disease control and overall survival (OS). Methods and Materials: We retrospectively reviewed all patients through December 2008, who, after surgical resection, underwent SRS to the tumor bed, deferring WBRT. Multiple factors were analyzed for time to intracranial recurrence (ICR), whether local recurrence (LR) at the surgical bed or “distant” recurrence (DR) in the brain, formore » time to WBRT, and for OS. Results: A total of 49 lesions in 47 patients were treated with postoperative SRS. With median follow-up of 9.3 months (range, 1.1-61.4 months), local control rates at the resection cavity were 85.5% at 1 year and 66.9% at 2 years. OS rates at 1 and 2 years were 52.5% and 31.7%, respectively. On univariate analysis (preoperative) tumors larger than 3.0 cm exhibited a significantly shorter time to LR. At a cutoff of 2.0 cm, larger tumors resulted in significantly shorter times not only for LR but also for DR, ICR, and salvage WBRT. While multivariate Cox regressions showed preoperative size to be significant for times to DR, ICR, and WBRT, in similar multivariate analysis for OS, only the graded prognostic assessment proved to be significant. However, the number of intracranial metastases at presentation was not significantly associated with OS nor with other outcome variables. Conclusions: Larger tumor size was associated with shorter time to recurrence and with shorter time to salvage WBRT; however, larger tumors were not associated with decrements in OS, suggesting successful salvage. SRS to the tumor bed without WBRT is an effective treatment for resected brain metastases, achieving local control particularly for tumors up to 3.0 cm diameter.« less

  3. Association of haemodynamic changes measured by serial central venous saturation during ultrafiltration for acutely decompensated heart failure with diuretic resistance and change in renal function.

    PubMed

    Vazir, Ali; Simpkin, Victoria L; Marino, Philip; Ludman, Andrew; Banya, Winston; Tavazzi, Guido; Bastin, Anthony J; Trenfield, Sarah; Ghori, Arshad; Alexander, Peter D; Griffiths, Mark; Price, Susanna; Sharma, Rakesh; Cowie, Martin R

    2016-10-01

    Patients with acute decompensated heart failure with diuretic resistance (ADHF-DR) have a poor prognosis. The aim of this study was to assess in patients with ADHF-DR, whether haemodynamic changes during ultrafiltration (UF) are associated with changes in renal function (Δcreatinine) and whether Δcreatinine post UF is associated with mortality. Seventeen patients with ADHF-DR underwent 20 treatments with UF. Serial bloods (4-6 hourly) from the onset of UF treatment were measured for renal function, electrolytes and central venous saturation (CVO2). Univariate and multivariate analysis were performed to assess the relationship between changes in markers of haemodynamics [heart rate (HR), systolic blood pressure (SBP), packed cell volume (PCV) and CVO2] and Δcreatinine. Patients were followed up and mortality recorded. Cox-regression survival analysis was performed to determine covariates associated with mortality. Renal function worsened after UF in 17 of the 20 UF treatments (baseline vs. post UF creatinine: 164±58 vs. 185±69μmol/l, P<0.01). ΔCVO2 was significantly associated with Δcreatinine [β-coefficient of -1.3 95%CI (-1.8 to -0.7), P<0.001] and remained significantly associated with Δcreatinine after considering changes in SBP, HR and PCV [P<0.001]. Ten (59%) patients died at 1-year and 15(88%) by 2-years. Δcreatinine was independently associated with mortality (adjusted-hazard ratio 1.03 (1.01 to 1.07) per 1μmol/l increase in creatinine; P=0.02). Haemodynamic changes during UF as measured by the surrogate of cardiac output was associated with Δcreatinine. Worsening renal function at end of UF treatment occurred in the majority of patients and was associated with mortality. Copyright © 2016. Published by Elsevier Ireland Ltd.

  4. 78 FR 62639 - National Eye Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Eye Institute... personal privacy. Name of Committee: National Eye Institute Special Emphasis Panel; NEI Clinical and.... Contact Person: Brian Hoshaw, Ph.D., Scientific Review Officer, National Eye Institute, National...

  5. Modeling the Effect of Temperature on Ozone-Related Mortality.

    EPA Science Inventory

    Modeling the Effect of Temperature on Ozone-Related Mortality. Wilson, Ander, Reich, Brian J, Neas, Lucas M., Rappold, Ana G. Background: Previous studies show ozone and temperature are associated with increased mortality; however, the joint effect is not well explored. Underst...

  6. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Administrator Michael Griffin, right, and Brian Chase, NASA's Assistant Administrator for Legislative Affairs confer prior to the start of a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  7. Annual Report 2011 (RAND Arroyo Center)

    DTIC Science & Technology

    2011-01-01

    Portfolio Management for Army Science and Technology Programs Under Uncertainties Brian G. Chow, Richard Silberglitt, Scott Hiromoto, Caroline Reilly, and...in the ceremony and requested publishing of the promotion order. LTC Speaks’s spouse, Catherine, and son, Mason, pinned the silver oak leaf to each

  8. The Effectiveness of an Interactive Map Display in Tutoring Geography

    DTIC Science & Technology

    1976-08-01

    MCIT LG Hanscom Field Bedford, MA 01730 Director, Office of Manpower Utilization Headquarters, Marine Corps (Code MPU ) MCB (Building 2009...Lantz University of Denver Denver Research Institute Industrial Economics Division Denver, CO 80210 Mr. Brian McNally Educational Testing Service

  9. Differences in incidence of diabetic retinopathy between type 1 and 2 diabetes mellitus: a nine-year follow-up study.

    PubMed

    Romero-Aroca, Pedro; Navarro-Gil, Raul; Valls-Mateu, Aida; Sagarra-Alamo, Ramon; Moreno-Ribas, Antonio; Soler, Nuria

    2017-10-01

    To determine the incidence of any diabetic retinopathy (any-DR), sight-threatening diabetic retinopathy (STDR) and diabetic macular oedema (DMO) and their risk factors in type 1 diabetes mellitus (T1DM) over a screening programme. Nine-year follow-up, prospective population-based study of 366 patients with T1DM and 15 030 with T2DM. Epidemiological risk factors were as follows: current age, age at DM diagnosis, sex, type of DM, duration of DM, arterial hypertension, levels of glycosylated haemoglobin (HbA 1c ), triglycerides, cholesterol fractions, serum creatinine, estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR). Sum incidence of any-DR was 47.26% with annual incidence 15.16±2.19% in T1DM, and 26.49% with annual incidence 8.13% in T2DM. Sum incidence of STDR was 18.03% with annual incidence 5.77±1.21% in T1DM, and 7.59% with annual incidence 2.64±0.15% in T2DM. Sum incidence of DMO was 8.46% with annual incidence 2.68±038% in patients with T1DM and 6.36% with annual incidence 2.19±0.18% in T2DM. Cox's survival analysis showed that current age and age at diagnosis were risk factors at p<0.001, as high HbA1c levels at p<0.001, LDL cholesterol was significant at p<0.001, eGFR was significant at p<0.001 and UACR at p=0.017. The incidence of any-DR and STDR was higher in patients with T1DM than those with T2DM. Also, the 47.26% sum incidence of any-DR in patients with T1DM was higher than in a previous study (35.9%), which can be linked to poor metabolic control of DM. Our results suggest that physicians should be encouraged to pay greater attention to treatment protocols for T1DM in patients. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  10. The effect size of type 2 diabetes mellitus on tuberculosis drug resistance and adverse treatment outcomes.

    PubMed

    Perez-Navarro, Lucia Monserrat; Restrepo, Blanca I; Fuentes-Dominguez, Francisco Javier; Duggirala, Ravindranath; Morales-Romero, Jaime; López-Alvarenga, Juan Carlos; Comas, Iñaki; Zenteno-Cuevas, Roberto

    2017-03-01

    To evaluate the effect size of type 2 diabetes mellitus (T2DM) on tuberculosis (TB) treatment outcomes and multi drug resistance (MDR). A cohort with 507 individuals with diagnosed TB included 183 with coexistence of T2DM and TB (TB-T2DM). Participants were identified at the time of TB diagnosis and followed during the course of TB treatment. Then we computed relative risks and adjustments by Cox proportional hazards for outcome variables (drug resistance, death, relapse, treatment failure), and the size of their effect as Cohen's-d. Patients with TB-T2DM were more likely to remain positive for acid-fast bacilli after two months of anti-TB treatment RR = [2.01 (95% CI: 1.3, 3.1)], to have drug resistant (DR) [OR 3.5 (95% CI: 1.8, 6.7)] and multi-drug resistant (MDR) TB [OR 3.5 (95% CI: 1.8, 7.1)]. The Cohen's-d for DR or MDR in T2DM was 0.69 when compared with non-DM subjects. The T2DM patients had higher odds of resistance to isoniazid (OR 3.9, 95% CI: 2.01, 7.9), rifampicin (OR 3.4, 95% CI: 1.6, 7.2) and pyrazinamide (OR 9.4, 95% CI: 2.8, 25.6), and their effect sizes were ≥0.67. Patients with TB-T2DM (versus no DM) were more likely to present with MDR TB (HR 3.1; 95% CI: 1.7, 5.8; p < 0.001), treatment failure (HR 2.04; 95% CI: 1.07, 3.8; p = 0.02) and relapse (HR 1.86; 95% CI: 1.09, 3.1; p = 0.02), with effect size ≥0.34. T2DM showed a substantial contribution to the presence of DR or MDR-TB and to adverse clinical outcomes during and after TB treatment. Our findings support the importance for routine screening of T2DM among newly-diagnosed TB patients in order to stratify them for immediate DR assessment, and highlight the need for clinical trials to evaluate variations to the standard TB treatment in TB-T2DM to prevent adverse treatment outcomes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. The Early Toarcian oceanic anoxic event: Paleoenvironmental and paleoclimatic change across the Alpine Tethys (Switzerland)

    NASA Astrophysics Data System (ADS)

    Fantasia, Alicia; Föllmi, Karl B.; Adatte, Thierry; Spangenberg, Jorge E.; Montero-Serrano, Jean-Carlos

    2018-03-01

    Paleoenvironmental and paleoclimatic change associated with the Toarcian oceanic anoxic event (T-OAE) was evaluated in five successions located in Switzerland. They represent different paleogeographic settings across the Alpine Tethys: the northern shelf (Gipf, Riniken and Rietheim), the Sub-Briançonnais basin (Creux de l'Ours), and the Lombardian basin (Breggia). The multi-proxy approach chosen (whole-rock and clay mineralogy, phosphorus, major and trace elements) shows that local environmental conditions modulated the response to the T-OAE across the Alpine Tethys. On the northern shelf and in the Sub-Briançonnais basin, high kaolinite contents and detrital proxies (detrital index, Ti, Zr, Si) in the T-OAE interval suggest a change towards a warmer and more humid climate coupled with an increase in the chemical weathering rates. In contrast, low kaolinite content in the Lombardian basin is likely related to a more arid climate along the southern Tethys margin and/or to a deeper and more distal setting. Redox-sensitive trace-element (V, Mo, Cu, Ni) enrichments in the T-OAE intervals reveal that dysoxic to anoxic conditions developed on the northern shelf, whereas reducing conditions were less severe in the Sub-Briançonnais basin. In the Lombardian basin well-oxygenated bottom water conditions prevailed. Phosphorus (P) speciation analysis was performed at Riniken and Creux de l'Ours. This is the first report of P speciation data for T-OAE sections, clearly suggesting that high P contents during this time interval are mainly linked to the presence of an authigenic phases and fish remains. The development of oxygen-depleted conditions during the T-OAE seems to have promoted the release of the organic-bound P back into the water column, thereby further sustaining primary productivity in a positive feedback loop.

  12. Factors associated with the development of cytomegalovirus infection following solid organ transplantation.

    PubMed

    da Cunha-Bang, Caspar; Sørensen, Søren S; Iversen, Martin; Sengeløv, Henrik; Hillingsø, Jens G; Rasmussen, Allan; Mortensen, Svend A; Fox, Zoe V; Kirkby, Nikolai S; Christiansen, Claus B; Lundgren, Jens D

    2011-05-01

    Infection with cytomegalovirus (CMV) remains a potentially serious complication in transplant patients. In this study we explored the risk factors for CMV infection in the 12 months following a solid organ transplantation (n = 242) in patients monitored for CMV infection from 2004 to 2007. CMV infection was defined as 2 consecutive quantifiable CMV-polymerase chain reaction (PCR) values or 1 measurement of >3000 copies/ml. Data describing pre- and post-transplantation variables were extracted from electronic health records. Time to CMV infection was investigated using Cox proportional hazards analysis. Overall, 31% (75/242) of solid organ transplant patients developed CMV infection: 4/8 (50.0%) heart, 15/43 (34.9%) liver, 30/89 (33.7%) lung and 26/102 (25.5%) kidney transplant patients. The risk of CMV infection according to donor (D)/recipient (R) CMV serostatus (positive + or negative-) was highest for D+/R-(adjusted hazard ratio 2.6, 95% confidence interval 1.6-4.2) vs D+/R+, and was reduced for D-/R+(adjusted hazard ratio 0.2, 95% confidence interval 0.2-0.8) vs D+/R+. Positive donor CMV-serostatus is a major risk factor for CMV-infection in CMV-na ve recipients, but also in recipients with positive CMV-serostatus. Conversely, if donor is CMV serostatus is negative, the risk of CMV infection is low, irrespective of recipients CMV-serostatus. These findings suggest poorer immune function towards donor-induced strains of CMV versus recipient own latent strains.

  13. Psoriasis Doesn't Slow Down Texan Brian LaFoy | NIH MedlinePlus the Magazine

    MedlinePlus

    ... I pretty much tried every topical there was." Quality of life issue By the time he reached his mid- ... the lesions common in psoriasis. "It became a quality of life issue for me," LaFoy says. "I'd lost ...

  14. Finding common ground: Montana forest restoration committee

    Treesearch

    Sharon Ritter

    2008-01-01

    What in the world made Brian Kahn think he could get consensus among 34 people representing timber, environmental, government, and off-highway vehicle groups - especially when the topic was forest restoration? "Actually," he said, "I didn't believe we could get 100% consensus. But we did

  15. 78 FR 46593 - National Eye Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Eye Institute... personal privacy. Name of Committee: National Eye Institute Special Emphasis Panel; NEI K99 Review. Date... Person: Brian Hoshaw, Ph.D. Scientific Review Officer, National Eye Institute, National Institutes of...

  16. Dyscalculia in Harrow

    ERIC Educational Resources Information Center

    Messenger, Chris; Emerson, Jane; Bird, Ronit

    2007-01-01

    In this article, the authors offer three definitions of dyscalculia, then describe the background and initial progress of the Harrow Dyscalculia Project. Their project in Harrow is associated with ongoing research into numeracy and brain development led by Brian Butterworth, Professor of Cognitive Neuropsychology at UCL. Pupils from Harrow schools…

  17. "The Chinatown Foray" as Sensational Pedagogy

    ERIC Educational Resources Information Center

    Springgay, Stephanie

    2011-01-01

    Thinking through affective theories by Alfred North Whitehead, Giles Deleuze, and Brian Massumi, this paper proposes an understanding of pedagogy that is sensational. To consider affective theories and their implications for educational research, I engage with a relational artwork, "The Chinatown Foray," by Toronto-based artist Diane…

  18. 78 FR 37210 - Notice of Intent To Grant Partially Exclusive Patent License; Jinga-hi, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-20

    ... Hull St., Bldg. A33 Room 2531, San Diego, CA 92152-5001. FOR FURTHER INFORMATION CONTACT: Brian Suh... 72120, 53560 Hull St., Bldg. A33 Room 2531, San Diego, CA 92152-5001, telephone 619-553-5118, email...

  19. 76 FR 10341 - Notice of Intent To Grant Partially Exclusive Patent License; Dakota Technologies, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ..., 53560 Hull St., Bldg. A33 Room 2305, San Diego, CA 92152-5001. FOR FURTHER INFORMATION CONTACT: Brian..., Code 72120, 53560 Hull St., Bldg. A33 Room 2305, San Diego, CA 92152-5001, telephone 619-553-5118, E...

  20. 1301163

    NASA Image and Video Library

    2013-10-29

    MSFC MECHANICAL ENGINEER BRIAN WEST, (L), DEMONSTRATES STRUCTURED LIGHT SCANNING PROCESS TO MEMBERS OF THE BREMEN, GERMANY, BUSINESS DELEGATION WHO VISITED MARSHALL RECENTLY. SENATOR MARTIN GÜNTHNER, MINISTRY OF ECONOMIC AFFAIRS, LABOUR AND PORTS (CENTER) VIEWS THE PRESSURE VESSEL BEING SCANNED. AT RIGHT IS BERND SCHMELING, SENIOR MANAGER PROCUREMENT, AIRBUS OPERATIONS GMBH

  1. NextGen Avionics Roadmap Version 1.0

    DTIC Science & Technology

    2008-10-24

    monetized benefit streams when available. Since the source analyses had been conducted at different times using a range of operational and economic...Mrkoci BAE Systems Dave Nakamura Boeing Rob Pappas FAA Dharmesh Patel Honeywell Art Politano FAA Jean- Claude Richard Thales Avionics Brian E. Smith

  2. Documentation of new mission control center White Flight Control Room (FLCR)

    NASA Image and Video Library

    1995-06-06

    Documentation of the new mission control center White Flight Control Room (FLCR). Excellent overall view of White FLCR with personnel manning console workstations (11221). Fisheye lens perspective from Flight Director station with Brian Austin (11222). Environmental (EECOM) workstation and personnel (11223).

  3. KSC-03PD-2144

    NASA Technical Reports Server (NTRS)

    2003-01-01

    KENNEDY SPACE CENTER, FLA. (From left) Brian Duffy, Lockheed Martin vice president/associate program manager, Mildred Carter and Col. (Ret.) Herbert E. Carter, one of the Tuskegee Airmen, attend a dinner sponsored by the KSC Spaceflight and Life Sciences Office. Col. Carter was a guest speaker at the dinner.

  4. Peregrine Rocket Motor Test at the Ames Outdoor Aerodynamic Rese

    NASA Image and Video Library

    2017-02-15

    From Left to Right: Ashley Karp (NASA JPL), Hunjoo Kim (NASA JPL), Brian Schratz (NASA JPL) and Kyle Botteon (NASA JPL) Testing the Peregrine Hybrid Rocket Engine at the Outdoor Aerodynamic Research Facility (building N249, OARF) at NASA’s Ames Research Center.

  5. Career Profile: Flight Operations Engineer (Aeronautics) Brian Griffin

    NASA Image and Video Library

    2014-10-17

    Operations engineers at NASA's Armstrong Flight Research Center help to advance science, technology, aeronautics, and space exploration by managing operational aspects of a flight research project. They serve as the governing authority on airworthiness related to the modification, operation, or maintenance of specialized research or support aircraft so those aircraft can be flown safely without jeopardizing the pilots, persons on the ground or the flight test project. With extensive aircraft modifications often required to support new research and technology development efforts, operations engineers are key leaders from technical concept to flight to ensure flight safety and mission success. Other responsibilities of an operations engineer include configuration management, performing systems design and integration, system safety analysis, coordinating flight readiness activities, and providing real-time flight support. This video highlights the responsibilities and daily activities of NASA Armstrong operations engineer Brian Griffin during the preparation and execution of flight tests in support of aeronautics research. http://www.nasa.gov/centers/armstrong/home/ http://www.nasa.gov/

  6. Network analysis of the Viking Age in Ireland as portrayed in Cogadh Gaedhel re Gallaibh.

    PubMed

    Yose, Joseph; Kenna, Ralph; MacCarron, Máirín; MacCarron, Pádraig

    2018-01-01

    Cogadh Gaedhel re Gallaibh ('The War of the Gaedhil with the Gaill') is a medieval Irish text, telling how an army under the leadership of Brian Boru challenged Viking invaders and their allies in Ireland, culminating with the Battle of Clontarf in 1014. Brian's victory is widely remembered for breaking Viking power in Ireland, although much modern scholarship disputes traditional perceptions. Instead of an international conflict between Irish and Viking, interpretations based on revisionist scholarship consider it a domestic feud or civil war. Counter-revisionists challenge this view and a long-standing and lively debate continues. Here, we introduce quantitative measures to the discussions. We present statistical analyses of network data embedded in the text to position its sets of interactions on a spectrum from the domestic to the international. This delivers a picture that lies between antipodal traditional and revisionist extremes; hostilities recorded in the text are mostly between Irish and Viking-but internal conflict forms a significant proportion of the negative interactions too.

  7. Brian Davison: Seeking New Challenges, Forging New Connections in Bioenergy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Davison, Brian

    Brian Davison has advice for anyone planning a long career in science, gleaned from more than three decades in the field: Appreciate the ‘eureka’ moments, both big and small. “You don’t find joy every day in any job, but if I find a moment at least once or twice a month, it makes everything else really worthwhile,” Davison said. “Having those moments when you helped articulate and crystallize something, to come up with a brand-new idea that no one thought of yet, it’s just exciting.” Davison is chief scientist for the Systems Biology and Biotechnology Initiative at the Department ofmore » Energy’s Oak Ridge National Laboratory and an adjunct professor of chemical and biomolecular engineering at the University of Tennessee. He is also a science coordinator in the BioEnergy Science Center, a DOE-funded research organization performing basic and applied science dedicated to improving yields of biofuels.« less

  8. The NSET Subcommittee | Nano

    Science.gov Websites

    Charles Ying Nuclear Regulatory Commission (NRC) Brian Thomas* U.S. Department of Agriculture (USDA ) Agriculture Research Service (ARS) James Lindsay Forest Service (FS) World L.S. Nieh National Institute of Food and Agriculture (NIFA) Hongda Chen U.S. International Trade Commission (USITC) Elizabeth R

  9. 78 FR 13689 - National Institute of General Medical Sciences; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... Person: Brian R. Pike, Ph.D., Scientific Review Officer, Office of Scientific Review, National Institute... R. Pike, Ph.D., Scientific Review Officer, National Institute of General Medical Sciences, National..., Cell Biology and Biophysics Research; 93.859, Pharmacology, Physiology, and Biological Chemistry...

  10. The Common Sense Revolution. The Iconoclast.

    ERIC Educational Resources Information Center

    McMurtry, John

    1996-01-01

    Presents a scathing review of supply-side economics and its effect on social programs. Argues that the Reagan administration purposefully incurred massive government debt in order to justify reducing social spending. Maintains that Canadian Prime Minister Brian Mulroney followed a similar course. Includes trenchant criticism of Canada's public…

  11. Transformation & Metamorphosis

    ERIC Educational Resources Information Center

    Lott, Debra

    2009-01-01

    The sculptures of Canadian artist Brian Jungen are a great inspiration for a lesson on creating new forms. Jungen transforms found objects into unique creations without fully concealing their original form or purpose. Frank Stella's sculpture series, including "K.132,2007" made of stainless steel and spray paint, is another great example of…

  12. Decisionmaker Forums

    DTIC Science & Technology

    2005-03-01

    Committee professional staff, Brian Hurley of Edward Martin & Associates, Michael Kussman of the VA, Steve Lillie of DoD, Steve Mirick ofAMSUSBob...Michael Kussman of VHA; Bruce Levine of VHA; Miklos Losonczy of VHA; Susan Mather of VHA; Theodore Nam of DoD; Harold Wain of DoD; Terry Washam of

  13. Developing a low cortisol responsive line of channel catfish, Ictalurus punctatus

    USDA-ARS?s Scientific Manuscript database

    Nagaraj G. Chatakondi and Brian C. Peterson USDA ARS Warmwater Aquaculture Research Unit, 141 Experiment Station Road, Stoneville, MS 38776. nagaraj.chatakondi@ars.usda.gov Channel catfish, Ictalurus punctatus is the most important farm-raised aquacultured species in the USA. Stressors in aquacultu...

  14. 35. Photo of concrete arch culvert constructed by Puget Sound ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. Photo of concrete arch culvert constructed by Puget Sound Construction Company, 1911, for the Northern Pacific Railroad, over flume. Photo by Brian C. Morris, Puget Power, 1989. - Puget Sound Power & Light Company, White River Hydroelectric Project, 600 North River Avenue, Dieringer, Pierce County, WA

  15. Lessons Learned in Part-of-Speech Tagging of Conversational Speech

    DTIC Science & Technology

    2010-10-01

    for conversational speech recognition. In Plenary Meeting and Symposium on Prosody and Speech Processing. Slav Petrov and Dan Klein. 2007. Improved...inference for unlexicalized parsing. In HLT-NAACL. Slav Petrov. 2010. Products of random latent variable grammars. In HLT-NAACL. Brian Roark, Yang Liu

  16. 77 FR 1752 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... POSTAL REGULATORY COMMISSION [Docket No. A2012-97; Order No. 1085] Post Office Closing AGENCY... the closing of the Ashton, Iowa, post office has been filed. It identifies preliminary steps and... office in Ashton, Iowa. The first petition for review received December 9, 2011, was filed by Brian D...

  17. Peregrine Rocket Motor Test at the Ames Outdoor Aerodynamic Rese

    NASA Image and Video Library

    2017-02-15

    From Left to Right: 1. Hunjoo Kim (NASA JPL) 2. Kyle Botteon (NASA JPL) 3. Ashley Karp (NASA JPL) 4. Brian Schratz (NASA JPL) Testing the Peregrine Hybrid Rocket Engine at the Outdoor Aerodynamic Research Facility (building N249, OARF) at Ames Research Center.

  18. Google Moon Press Conference

    NASA Image and Video Library

    2009-07-19

    Brian McLendon, VP of Engineering, Google, Inc., speaks during a press conference, Monday, July 20, 2009, announcing the launch of Moon in Google Earth, an immersive 3D atlas of the Moon, accessible within Google Earth 5.0, Monday, July 20, 2009, at the Newseum in Washington. Photo Credit: (NASA/Bill Ingalls)

  19. 76 FR 56745 - Notice of Availability of Government-Owned Inventions; Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... No. 12/175262: Coupled Electric Field Sensors for DC Target Electric Field Detection; U.S. Patent Application No. 12/732023: Coupled Bi-Stable Microcircuit System for Ultra-Sensitive Electrical and Magnetic... Electric Field Sensing Utilizing Differential Transistors Pairs. FOR FURTHER INFORMATION CONTACT: Brian Suh...

  20. The Resurgence of Cosmic Storytellers

    ERIC Educational Resources Information Center

    Swimme, Brian

    2013-01-01

    Brian Swimme's insights about the Story of the Universe look to the unifying impact of a "cosmic story" that speaks to all cultures and nations. Swimme suggests that humans are now able, through science and narrative, to present a story which will make us all a "cohesive tribe" while answering the universal questions of…

  1. New Hires at the National Cancer Institute at Frederick | Poster

    Cancer.gov

    Forty-nine people joined the facility in September and October 2013. The National Cancer Institute welcomes… Aamir Akram Clarissa Alexander Robert Buckheit Brian Chan Kelly Dempsey Christopher Descalzi Ahmed Fahim Devikala Gurusamy Jaewoo Hong Rhushikesh Kulkarni James Shaum Dionysios Watson Yuheng Xi Yi Xiang Thomas Zengeya

  2. 75 FR 22175 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ..., James Layfield, Dana O. Lundgren, Raymond Meza, Robert L. Moore, Charles Noll, George H. Southland..., Robert Key, Christopher D. Linden, Patrick W. Merkel, Gene M. Morris, James L. Putnam, Jr., Donald W.... Glaser, George Klopf, Luke R. Lafley, Brian K. La Joie, John L. Langill, Gregg A. Lindberg, John R...

  3. 75 FR 65528 - Membership of National Science Foundation's Senior Executive Service Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ..., Office of Budget, Finance and Award Management, and Chief Financial Officer; Brian W. Stone, Deputy... Director, Division of Human Resource Management and Chief Human Capital Officer, National Science..., Division of Human Resource Management and Chief Human Capital Officer; Mark L. Weiss, Director, Division of...

  4. DESIGNING SULFATE-REDUCING BACTERIA FIELD-BIOREACTORS USING THE BEST MODEL

    EPA Science Inventory

    DESIGNING SULFATE-REDUCING BACTERIA FIELD-BIOREACTORS USING THE BEST MODEL

    Marek H. Zaluski1,3, Brian T. Park1, Diana R. Bless2

    1 MSE Technology Applications; 200 Technology Way, Butte, Montana 59701, USA
    2 U.S. EPA, Office of Research and Development, Cincinna...

  5. Integrating Space into an Air Expeditionary Force

    DTIC Science & Technology

    1999-04-01

    National Guard in space. Further thanks go out to Col Andersson, Col Hoapili, CAPT Huffine, LTC Glen Collins, USA, LTC Bill Bayles, USA, Maj Brian Creelman ...should be the senior space professional in theater, regardless of service. The main questions regarding a JSpOTF pertain to this task force’s physical

  6. One Web Satellites Ground Breaking

    NASA Image and Video Library

    2017-03-16

    Brian Holz, CEO of OneWeb Satellites, speaks during the groundbreaking ceremony at Kennedy's Exploration Park for OneWeb. The company, in partnership with Airbus, is building a 150,000-square-foot factory to manufacture satellites that will connect all areas of the world to the Internet wirelessly. Photo credit: NASA/Kim Shiflett

  7. The Debate Over the National Standards: An Assessment by Three Historians.

    ERIC Educational Resources Information Center

    Adomanis, James F.; And Others

    1995-01-01

    Includes three brief essays responding to the current controversy over the National Standards for United States History. James F. Adomanis defends the standards and decries the media circus. Brian Boland casts a skeptical eye towards trendy educational reforms. Philip Reed Rulon finds the standards arbitrary and restrictive. (MJP)

  8. 78 FR 73919 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ... post all comments we receive, without change, to http://www.regulations.gov , including any personal... INFORMATION CONTACT: Mr. Brian Hancock, Flight Test Pilot, Project Support (ACE-112), Small Airplane....: FAA-2013-0795. Petitioner: Cirrus Design Corporation. Section of 14 CFR Affected: 14 CFR 23.177(b...

  9. Detection Capability of Linear-and-Power Processor for Random Burst Signals of Unknown Location

    DTIC Science & Technology

    1997-08-25

    Technology Directorate of the Office of Naval Research, Ronald Tipper (ONR-322B). The technical reviewer for this report was Brian F. Harrison (Code 2121...Research Laboratory, B. Adams R. Fiddler E. Franchi R. Wagstaff Naval Oceanographic Office, MS Naval Personnel Research and Development Center

  10. Isocrates, Sophistry, and Writing.

    ERIC Educational Resources Information Center

    Welch, Kathleen E.

    Some tentative connections can be made between 20th-century cultural and rhetorical reception of Isocrates' writing and selected issues in historical literacy. Specifically, two literacy scholars, David Bleich and Brian Street, the former a humanist and the latter an anthropologist, can be read concerning some issues in literacy as applied to…

  11. A Crew Exposure Study. Volume I. Offshore.

    DTIC Science & Technology

    1982-03-15

    in Percutaneous Penetra- tion in Man - Pesticides ," Archives of Environmental Health, Vol. 23, pp 208-211, 1971. 20. Bartek, M. J., et al., "Skin...OTO FI RCABNEISOS UT iA- 0 - . . -- • G. DISCHARGING OF HAZARDOUS WASTES FROM PLATFORMS 1. Middleditch, Brian S., Basile , Brenda, and Chang, Evelyn S

  12. Particulate Meso-scale Mechanics Diagnostics: Magnetic Sensors for Dynamic State Orientation

    DTIC Science & Technology

    2013-12-01

    Research Laboratory for giving this opportunity to work at the Eglin AFB, FL. REFERENCES 1. Brian D. Reding , “Development of Particulate Materials...Measurements," Sandia Report, 1984. 15. I.N. Tansel, B. Reding , W. L. Cooper, “Lagrangian Point State Estimation with Optimized, Redundant Induction Coil

  13. NOAA appoints members to Marine Protected Areas Federal Advisory Committee

    Science.gov Websites

    constituencies they represent are: Brian Baird, former assistant secretary for ocean and coastal policy , Portland, Oregon (conservation) Ryan Orgera, Ph.D., legislative representative, Coastal States Organization conserve and manage our coastal and marine resources. Join us on Twitter, Facebook, Instagram and our other

  14. Military Leadership Preparedness to Meet Counterinsurgency Requirements

    DTIC Science & Technology

    2008-03-19

    describes by Brian Holden Reid in a wicked spoof as a 6 “diminutive, blinking, bespectacled swot whose muscles compare with peas and who grows exhausted...Schoomaker “A Campaign Quality Army with Joint and Expeditionary Capabilities,” Parameters 34 (Summer 2004). 8 Lacquement, 212. 9 Steven M. Jones

  15. ENVIRONMENTAL PCB AND PESTICIDE EXPOSURE AND RISK OF ENDOMETRIOSIS

    EPA Science Inventory

    Environmental PCB and Pesticide Exposure and Risk of Endometriosis

    Germaine M. Buck1, John M. Weiner2, Hebe Greizerstein3, Brian Whitcomb1, Enrique Schisterman1, Paul Kostyniak3, Danelle Lobdell4, Kent Crickard5, and Ralph Sperrazza5

    1Epidemiology Branch, Division o...

  16. Ohio Water Resources Council

    Science.gov Websites

    Salt Storage Fact Sheet QUICK LINKS 2015-2019 Strategic Action Plan 2010-2014 Strategic Action Plan 2006 Strategic Action Plan OWRC Bylaws For More Information Brian Hall OWRC - State Agency Coordinating Program (Indirect Discharge) Primary Headwater Habitat Streams Remedial Action Plans (RAP) River Mile Maps

  17. Healthy Video Gaming: Oxymoron or Possibility?

    ERIC Educational Resources Information Center

    Yang, Stephen; Smith, Brian; Graham, George

    2008-01-01

    Stephen Yang, Brian Smith, and George Graham explore the potential of exergames as a tool to combat the growing problem of childhood and adolescent obesity. Exergames rely on sensing technology that allows on-screen activity to be controlled through physical activity, rather than through operation of a handheld controller. Researchers frequently…

  18. Naval Medical R and D News Special Edition: 2016 MHSRS Conference

    DTIC Science & Technology

    2016-09-01

    and Protect Against Dengue Virus At the Military Health System Research Symposium, Aug. 17, Lt. Brian Morrison, a scientist from Naval Medical...fight dengue virus. Fighting dengue is vital to operational health and readiness. This viral infection is spread through mosquito bites and can cause

  19. The Doubling Moment: Resurrecting Edgar Allan Poe

    ERIC Educational Resources Information Center

    Minnick, J. Bradley; Mergil, Fernando

    2008-01-01

    This article expands upon Jeffrey Wilhelm's and Brian Edmiston's (1998) concept of a doubling of viewpoints by encouraging middle level students to use dramatization to take on multiple perspectives, to pose interpretive questions, and to enhance critical inquiry from inside and outside of texts. The doubling moment is both the activation of…

  20. The Mcdonaldization of Academic Libraries and the Values of Transformational Change

    ERIC Educational Resources Information Center

    Nicholson, Karen P.

    2015-01-01

    In his article "The McDonaldization of Academic Libraries?" Brian Quinn explores to what extent and to what effect academic libraries have become "McDonaldized," according to the concept developed by sociologist George Ritzer. Quinn identifies a number of ways in which the four dimensions of…

  1. Meaningful Real-Time Graphics Workstation Performance Measurements

    DTIC Science & Technology

    1988-11-01

    alike can effectively operate the program with little or no help from user’s manuals or other users. A thorough and efficient design of command line...Specifica- tions, San Jose, California, 1988. 4. Apgar , Brian, Bersack, Bret and Mammen, Abraham, "A Display System for the Stellarr m Graphics

  2. 76 FR 67765 - Notice of Availability of Uranium Enrichment Fuel Cycle Facility's Inspection Reports Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... Uranium Enrichment Fuel Cycle Facility's Inspection Reports Regarding Louisiana Energy Services, National..., Uranium Enrichment Branch, Division of Fuel Cycle Safety and Safeguards, Office of Nuclear Material Safety... Commission. Brian W. Smith, Chief, Uranium Enrichment Branch, Division of Fuel Cycle Safety and Safeguards...

  3. Fast Movements, Slow Processes

    ERIC Educational Resources Information Center

    Jordan, Jay

    2016-01-01

    This semester, for the second time in the last couple of years, the author is leading a graduate seminar on histories of rhetoric. Little scholarship traces the development of multilingual composition in antiquity (with Brian Ray's article as a clear and excellent exception), so the author typically feels like students hit a rich but untapped…

  4. 75 FR 33167 - Technical Amendment Language Change From “Wholly” to “Fully”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... SOCIAL SECURITY ADMINISTRATION 20 CFR Parts 404, 405, 408, 416, and 418 [Docket No. SSA-2009-0062] RIN 0960-AH16 Technical Amendment Language Change From ``Wholly'' to ``Fully'' AGENCY: Social Security... these final rules, call Brian J. Rudick, Office of Regulations, Social Security Administration, 6401...

  5. An Inevitable Moment: US Brain Drain

    ERIC Educational Resources Information Center

    Coppola, Brian P.

    2015-01-01

    In this article, Brian Coppola begins by discussing the 2007 National Academies of Sciences (NAS) publication, "Rising Above the Gathering Storm" which called for for reprioritizing investments because "the world is changing rapidly, and our advantages are no longer unique. Without a renewed effort to bolster the foundations of our…

  6. Is the U.S. Army Field Artillery Prepared to Support the Next Major Combat Operation?

    DTIC Science & Technology

    2013-05-23

    Coyle, C. John Langley Jr., Brian J . Gibson, Robert A . Novack, Edward J . Bardi , Supply Chain Management; A Logistics Perspective (Mason, OH: South...Edward J . Bardi . Supply Chain Management; A Logistics Perspective. Mason, OH: South-Western Cengage Learning, 2008. Dastrup, Boyd. The Field...

  7. Design, Disability and Play: The Animal Politics of Education

    ERIC Educational Resources Information Center

    Jaarsma, Ada S.

    2016-01-01

    This article draws out the materialist import of the turn towards universal design in learning. Bringing Brian Massumi's recent work on play together with disability studies, it identifies design as integral to the embodied dynamics of classrooms. Contrasting neo-Darwinist presumptions with materialist insights by thinkers like Tim Ingold, the…

  8. Ranking by Medians

    ERIC Educational Resources Information Center

    Martin, Brian

    2016-01-01

    Brian Martin describes a difficult committee meeting he once attended which consisted of one representative from each department. When the meeting ended it left a bitter taste for many who participated. Having learned from this experience, Martin became a chair of the committee and tried a new system that overcame many of the previous problems.…

  9. Counterfeit Parts Prevention Strategies Guide

    DTIC Science & Technology

    2014-06-24

    Boeing Byron Knight knightby@nro.mil NRO Hans Koenigsmann hans.koenigsmann@spacex.c om SpaceX James Koory james.koory@rocket.com Rocket Brian Kosinski...Deborah Valley deborah.valley@ll.mit.edu MIT Fred Van Milligen fvanmilligen@jdsu.com JDSU Marvin VanderWeg marvin.vanderwag@spacex.c om SpaceX Gerrit

  10. Technical Risk Identification at Program Inception

    DTIC Science & Technology

    2014-04-20

    boeing.com Byron Knight NRO knightby@nro.mil Hans Koenigsmann SpaceX hans.koenigsmann@spacex.c om James Koory Rocket james.koory@rocket.com Brian Kosinski...Deborah Valley MIT deborah.valley@ll.mit.edu Fred Van Milligen JDSU fvanmilligen@jdsu.com Marvin VanderWeg SpaceX marvin.vanderwag@spacex.c om Gerrit

  11. Prognostic nomogram for previously untreated adult patients with acute myeloid leukemia

    PubMed Central

    Zheng, Zhuojun; Li, Xiaodong; Zhu, Yuandong; Gu, Weiying; Xie, Xiaobao; Jiang, Jingting

    2016-01-01

    This study was designed to perform an acceptable prognostic nomogram for acute myeloid leukemia. The clinical data from 311 patients from our institution and 165 patients generated with Cancer Genome Atlas Research Network were reviewed. A prognostic nomogram was designed according to the Cox's proportional hazard model to predict overall survival (OS). To compare the capacity of the nomogram with that of the current prognostic system, the concordance index (C-index) was used to validate the accuracy as well as the calibration curve. The nomogram included 6 valuable variables: age, risk stratifications based on cytogenetic abnormalities, status of FLT3-ITD mutation, status of NPM1 mutation, expression of CD34, and expression of HLA-DR. The C-indexes were 0.71 and 0.68 in the primary and validation cohort respectively, which were superior to the predictive capacity of the current prognostic systems in both cohorts. The nomogram allowed both patients with acute myeloid leukemia and physicians to make prediction of OS individually prior to treatment. PMID:27689396

  12. Ibuprofen: from invention to an OTC therapeutic mainstay.

    PubMed

    Rainsford, K D

    2013-01-01

    The discovery of ibuprofen's anti-inflammatory activity by Dr (now Professor) Stewart Adams and colleagues (Boots Pure Chemical Company Ltd, Nottingham, UK) 50 years ago represented a milestone in the development of anti-inflammatory analgesics. Subsequent clinical studies were the basis for ibuprofen being widely accepted for treating painful conditions at high anti-rheumatic doses (≤ 2400 mg/d), with lower doses (≤ 1200 mg/d for ≤ 10 days) for mild-moderate acute pain (e.g. dental pain, headache, dysmenorrhoea, respiratory symptoms and acute injury). The early observations have since been verified in studies comparing ibuprofen with newer cyclo-oxygenase-2 selective inhibitors ('coxibs'), paracetamol and other non-steroidal anti-inflammatory drugs (NSAIDs). The use of the low-dose, non-prescription, over-the-counter (OTC) drug was based on marketing approval in 1983 (UK) and 1984 (USA); and it is now available in over 80 countries. The relative safety of OTC ibuprofen has been supported by large-scale controlled studies. It has the same low gastro-intestinal (GI) effects as paracetamol (acetaminophen) and fewer GI effects than aspirin. Ibuprofen is a racemate. Its physicochemical properties and the short plasma-elimination half-life of the R(-) isomer, together with its limited ability to inhibit cyclo-oxygenase-1 (COX-1) and thus prostaglandin (PG) synthesis, compared with that of S(+)-ibuprofen, are responsible for the relatively low GI toxicity. The R(-) isomer is then converted in the body to the S(+) isomer after absorption in the GI tract. Ex vivo inhibition of COX-1 (thromboxane A(2)) and COX-2 (PGE(2)) at the plasma concentrations of S(+)-ibuprofen corresponding to those found in the plasma following ingestion of 400 mg ibuprofen in dental and other inflammatory pain models provides evidence of the anti-inflammatory mechanism at OTC dosages. R(-)-ibuprofen has effects on leucocytes, suggesting that ibuprofen has anti-leucocyte effects, which underlie its anti-inflammatory actions. Future developments include novel gastro-tolerant forms for 'at risk' patients, and uses in the prevention of neuro-inflammatory states and cancers. © 2012 Blackwell Publishing Ltd.

  13. The World Science Festival

    NASA Astrophysics Data System (ADS)

    Pazmino, J.

    2012-06-01

    (Abstract only) New York City in the late 20th century rose to be a planetary capital for the sciences, not just astronomy. This growth was mainly in the academic sector but a parallel growth occurred in the public and home field. With the millennium crossing, scientists in New York agitated for a celebration of the City as a place for a thriving science culture. In 2008 they began World Science Festival. 2011 is the fourth running, on June 1-5, following the AAVSO/AAS meetings. World Science Festival was founded by Dr. Brian Greene, Columbia University, and is operated through the World Science Foundation. The Festival is "saturation science" all over Manhattan in a series of lectures, shows, exhibits, performances. It is staged in "science" venues like colleges and musea, but also in off-science spaces like theaters and galleries. It is a blend from hard science, with lectures like those by us astronomers, to science-themed works of art, dance, music. Events are fitted for the public, either for free or a modest fee. While almost all events are on Manhattan, effort has been made to geographically disperse them, even to the outer boroughs. The grand finale of World Science Festival is a street fair in Washington Square. Science centers in booths, tents, and pavilions highlight their work. In past years this fair drew 100,000 to 150,000 visitors. The entire Festival attracts about a quarter-million attendees. NYSkies is a proud participant at the Washington Square fair. It interprets the "Earth to the Universe" display, debuting during IYA-2009. Attendance at "Earth..." on just the day of the fair plausibly is half of all visitors in America. The presentation shows the scale and scope of World Science Festival, its relation to the City, and how our astronomers work with it.

  14. The World Science Festival

    NASA Astrophysics Data System (ADS)

    Pazmino, John

    2011-05-01

    New York City in the late 20th century rose to be a planetary capital for the sciences, not just astronomy. This growth is mainly in the academic sector but a parallel growth occurred in the public and home field. With the millennium crossing scientists in New York agitated for a celebration of the City as a place for a thriving science culture. In 2008 they began World Science Festival. 2011 is the fourth running, on June 1st-5th, following AAVSO/AAS. World Science Festival was founded by Dr Brian Greene, Columbia University, and is operated thru World Science Foundation. The Festival is 'saturation science' all over Manhattan in a series of lectures, shows, exhibits, performances. It is staged in 'science' venues like colleges and musea, but also in off-science spaces like theaters and galleries. It is a blend of hard science, with lectures like those by us astronomers to science-themed works of art, dance, music. Events are fitted for the public, either for free or a modest fee. While almost all events are on Manhattan, effort is done to geographicly disperse them, even to the outer boros. The grand finale of World Science Festival is a street fair in Washington Square. Science centers in booths, tents, pavilions highlight their work. This fair drew in past years 100,000 to 150,000 visitors. The entire Festival attracts about a quarter million. NYSkies is a proud participant at the Washington Square fair. It interprets the 'Earth to the Universe' display, debuting during IYA-2009. Attendance at 'Earth ...' on just the day of the fair plausibly is half of all visitors in America. The presentation shows the scale and scope of World Science Festival, its relation to the City, and how our astronomers work with it.

  15. Advancing Scholarship and Intellectual Productivity: An Interview with Clifford A. Lynch

    ERIC Educational Resources Information Center

    Hawkins, Brian L.

    2006-01-01

    In this article, Brian L. Hawkins, President of EDUCAUSE, interviews Clifford A. Lynch, Executive Director of the Coalition for Networked Information (CNI), and the recipient of the 2005 EDUCAUSE Award for Leadership in Public Policy and Practice, about, among other things, the current CNI initiatives, digital assets preservation, e-science,…

  16. Learning and Liberal Education: The Case of the Simon Family, 1912-1939

    ERIC Educational Resources Information Center

    McCulloch, Gary; Woodin, Tom

    2010-01-01

    Ernest and Shena Simon were leading liberal thinkers and activists in early twentieth-century England who were committed to preparing their children for public life by educating them in liberal values and active citizenship. They produced two sons, Roger and Brian, and a daughter, Antonia (Tony). Their "liberal education", and the…

  17. 77 FR 55208 - Transcontinental Gas Pipe Line Company, LLC; Notice of Intent To Prepare an Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... Southside Expansion Project (Project) involving construction and operation of facilities by Transcontinental... Beginning at 6:30 p.m., Brian's Restaurant (upstairs room), 625 East Atlantic Ave., South Hill, VA 23970.... The Project would include construction and operation of the following facilities: Approximately 91.4...

  18. An Asymmetrical Symmetry: How Convention Has Become Innovative Military Thought

    DTIC Science & Technology

    2010-03-01

    inside the fortress. The insurgents were taken by surprise and the Romans were fast in mounting a major attack. The lack of discipline and of a proper...Catholic Biblical Quarterly 43 (1981): 410. 114 Ibid., 426. 115 Brian McAllister Linn, The U.S. Army and Counterinsurgency in the Philippine War, 1899

  19. 78 FR 76399 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-17

    ... Charles A. Adams, Jr. (CT), Thomas W. Allee (WI), J.D. Ashcraft, Jr. (AL), Robert J. Berger III (PA). Michael E. Bingham (WA), Danny W. Bradley (DE), Richard A. Clark (GA), Winfred G. Clemenson (WA), Romero...), Carolyn C. Gardner (CT), Brian L. Gregory (IL), Alfonso Grijalva (CA), Jason E. Jacobus (KY), Ervin A...

  20. Issues of Education at Community Colleges: Essays by Fellows in the Mid-Career Fellowship Program at Princeton University.

    ERIC Educational Resources Information Center

    Princeton Univ., NJ. Mid-Career Fellowship Program.

    This collection contains nine essays, written by fellows in Princeton University's Mid-Career Fellowship Program, on contemporary issues facing community colleges. The essays included are "Language Minority Crossover Students: A Program to Address a New Challenge at Bergen Community College" (Brian Altano); "Retention Strategies for…

  1. Is "Learning without Limits" a Framework of Values?

    ERIC Educational Resources Information Center

    Booth, Tony

    2015-01-01

    In this article the author connects his own work with Brian Simon's writing on IQ (intelligence quotient) testing and selection and with the Learning without Limits project. He discusses the significance he gives to a values framework in the development of education and asks whether "Learning without Limits," in part, stands for a…

  2. Overcoming the Mechanism of Radioresistance in Neuroblastoma

    DTIC Science & Technology

    2014-06-01

    of Radioresistance in Neuroblastoma PRINCIPAL INVESTIGATOR: Brian Marples PhD CONTRACTING ORGANIZATION: William Beaumont Hospital Inc...COVERED 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Overcoming the Mechanism of Radioresistance in Neuroblastoma 5b. GRANT NUMBER 5c. PROGRAM...for highly aggressive advanced-stage neuroblastoma remains poor despite a multidisciplinary approach involving aggressive surgery, chemotherapy and

  3. Beyond Mediocrity: The Dialectics of Crisis in the Continuing Miseducation of Black Youth

    ERIC Educational Resources Information Center

    Lozenski, Brian D.

    2017-01-01

    In this essay, Brian D. Lozenski explores why Gloria Ladson-Billings's 2006 pronouncement of the nation's "education debt," as opposed to "achievement gap," has not gained traction in the national discourse around educational disparity. He contends that education debt is a more nuanced, historically based, and generative…

  4. 77 FR 64812 - National Institute of General Medical Sciences; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... Hilton Bethesda, 8120 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Saraswathy Seetharam, Ph.D... Drive, Room 3An18K, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Brian R. Pike, Ph.D... Chemistry Research; 93.862, Genetics and Developmental Biology Research; 93.88, Minority Access to Research...

  5. Seeing Music--Hearing Art

    ERIC Educational Resources Information Center

    Stephens, Pam

    2007-01-01

    In this article, the author explores the digital artwork of Brian Evans, a composer-artist who creates visualizations of sound. Through the years Evans' love for music and visual art led him to explore ways to work concurrently with image and sound. Digital technology proved to be such a means. Digital technology is based upon the transcription of…

  6. Faith in Action: Heritage Literacy as a Synchronisation of Belief, Word and Deed

    ERIC Educational Resources Information Center

    Rumsey, Suzanne Kesler

    2010-01-01

    The concept that literacies are best understood when examined in their context has been promoted for decades by socio-cultural literacy researchers such as Brian Street and Shirley Brice Heath. Street's term "literacy practice" is a combination of the actual "events of literacy" and the cultural, social and political…

  7. 77 FR 49792 - Environmental Impacts Statements; Notice of Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ....epa.gov/compliance/nepa/ . Weekly receipt of Environmental Impact Statements Filed 08/06/2012 Through..., Comment Period Ends: 10/01/2012, Contact: Brian Hasselbach 406-441-3908. EIS No. 20120266, Draft EIS, USFS... Ends: 10/01/2012, Contact: Harold Dyer 719-852-6215. EIS No. 20120267, Draft EIS, USN, VA, Outdoor...

  8. 76 FR 61140 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... he does not have diabetic retinopathy. He holds a Class A Commercial Driver's License (CDL) from Iowa... that he does not have diabetic retinopathy. He holds a Class A CDL from Massachusetts. Brian H... that he does not have diabetic retinopathy. He holds a Class B CDL from Vermont. Eric D. Blocker, Sr...

  9. The Real "Toll" of A. G. Bell: Lessons about Eugenics

    ERIC Educational Resources Information Center

    Greenwald, Brian H.

    2009-01-01

    Historian Brian Greenwald offers a revisionist interpretation of Bell. He reviews Bell's role and influence within the American eugenics movement and shows that Bell had the respect of the most prominent American eugenicists. His intimate knowledge of deafness, from personal experience with his mother and wife and from his studies of deaf people…

  10. List of U.S. Army Research Institute Research and Technical Publications for Public Release/Unlimited Distribution, Fiscal Year 2010

    DTIC Science & Technology

    2011-04-01

    Combat Skills: Modeling and Research Methods Anna T. Cianciolo, Brian T. Crabb, Peter S. Schaefer, Steven Jackson, & Jeff Grover. January 2010...operations: Low fidelity simulations for assessment. In Bartone, P., Johnsen, B., Eid, J., Violanti, J. C., & Laberg , J. (Eds.) Enhancing human

  11. Arthur Ashe Jr. Sports Scholars 2009--Male Finalists

    ERIC Educational Resources Information Center

    Diverse: Issues in Higher Education, 2009

    2009-01-01

    This article features the male and female finalists of the Arthur Ashe Jr. Sports Scholars 2009. The male finalists are: (1) Sam Bradford (University of Oklahoma); (2) Jamaal Parker (University of Georgia); (3) Masumi Turnbull (University of Kentucky); and (4) Brian Robiskie (The Ohio State University). The female finalists are: (1) Shardea Croes…

  12. The Mulroney Program and the Third World. Review '84, Outlook '85.

    ERIC Educational Resources Information Center

    North-South Inst., Ottawa (Ontario).

    A brief report traces some important connections between the central choices facing Canada and the three quarters of the world's population that live in the developing regions of Asia, Africa, and Latin America. Specific aspects of Canadian Prime Minister Brian Mulroney's governmental policy are examined. The following topics are considered:…

  13. Overcoming Dyslexia in Children, Adolescents, and Adults. Third Edition.

    ERIC Educational Resources Information Center

    Jordan, Dale R.

    This book aims to interpret recent research on dyslexia into practical information for those who work with individuals with dyslexia. Chapter 1 summarizes new information about how genetic codes determine brian development and how differences in brain structure cause dyslexia. Chapter 2 explains the perceptual and emotional nature of dyslexia.…

  14. 77 FR 18991 - Channel Spacing and Bandwidth Limitations for Certain Economic Area (EA)-Based 800 MHz...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... No. 11-110; FCC 12-25, by any of the following methods: Federal eRulemaking Portal: http://www... SUPPLEMENTARY INFORMATION section of this document. FOR FURTHER INFORMATION CONTACT: Brian Regan, Mobility... technology; and (e) ways to further reduce the information collection burden on small business concerns with...

  15. Person-Centered Planning with Youth and Adults Who Have Developmental Disabilities.

    ERIC Educational Resources Information Center

    Impact, 1998

    1998-01-01

    This feature issue of "Impact" focuses on person-centered planning with youth and adults who have developmental disabilities. Featured articles include: (1) "Centering on People: A Quiet Revolution" (Judith A. Snow); (2) "Look-and Understand-before You Leap" (Brian Abery and Marijo McBride), which describes the basic principles and values…

  16. School Public Relations and the SARS Epidemic in Toronto: An Interview with Brian Woodland.

    ERIC Educational Resources Information Center

    Partlow, Michelle Chaplin

    2003-01-01

    In an interview, a school district director of communication shares his experiences about the Severe Acute Respiratory Syndrome (SARS) outbreak in Ontario and offers timely advice for practitioners, including a proactive communications team and coordination of information with state and local health, police, and fire departments. (MLF)

  17. HABS drawing field team at east entrance to Cyclorama Building. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HABS drawing field team at east entrance to Cyclorama Building. Front, left to right: Robyn Chrabascz (Roger Williams University), Brian Carnahan (University of Arkansas), Noelle McManus (Edinburgh College of Art, ICOMOS/Great Britian), Amanda Loughlin (Kansas State University). Standing: Steven Utz, Field Supervisor. - Cyclorama Building, 125 Taneytown Road, Gettysburg, Adams County, PA

  18. NREL Scientist Brian Gregg Named AAAS Fellow | News | NREL

    Science.gov Websites

    discovered an entirely new photovoltaic effect. Even when sandwiched between two identical electrodes (i.e ., with zero bandbending) a PV effect is observed in these devices. Such an observation was unprecedented and challenged common assumptions about how solar cells work. This research set off a lifelong passion

  19. Oral Cancer Foundation

    MedlinePlus

    ... Cancer Survivor My wish is that in December this year the Oral Cancer Foundation can count on your help to fund [...] Read More OCF Southern California Oral Cancer Walk Wrap-up – 2016 By Brian Hill | 2016-12-14T22:05:33+00:00 October, 2016 | This last weekend the OCF 3rd Annual Southern California ...

  20. Broad & Capacious: A New Norm for Instructional Development in a Research Setting

    ERIC Educational Resources Information Center

    Coppola, Brian P.

    2016-01-01

    In this article, Brian Coppola begins with the single key concept of Boyer, in "Scholarship Reconsidered." The statement appears as follows: "We believe the time has come to move beyond the tired old "teaching versus research" debate and give the familiar and honorable term "scholarship" a broader, more capacious…

  1. Reason and Rationalization: A Theory of Modern Play

    ERIC Educational Resources Information Center

    Henricks, Thomas S.

    2016-01-01

    The author reviews historical attempts--mostly by European thinkers--to characterize modernity and its relationship to play. He discusses ideas from Friederich Schiller to Brian Sutton-Smith, all to set the ground for a theory of play in the modern world. Emphasizing the ideas of Max Weber--in particular his theory of rationalization and its…

  2. Children First: An Alternative Approach to Assessment (The Brian Simon Memorial Lecture 2015)

    ERIC Educational Resources Information Center

    Peacock, Alison

    2016-01-01

    The author discusses the importance of listening to children and engaging them in dialogue about their learning. She does not accept that assessment should entail labelling children and believes such practices encourage a culture of fixed "ability" thinking. Through examples of specific children, the author illustrates the importance of…

  3. 78 FR 67361 - Public Water System Supervision Program Revision for the Commonwealth of Kentucky

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... Drinking Water Branch, 61 Forsyth Street SW., Atlanta, Georgia 30303. FOR FURTHER INFORMATION CONTACT: Mr. Brian Thames, the EPA Region 4, Safe Drinking Water Branch, at the address given above, by telephone at... Kentucky submitted requests that the Region approve revisions to the Commonwealth's Safe Drinking Water Act...

  4. An Unnecessary Divorce: Integrating the Study of Affect and Emotion in New Media

    ERIC Educational Resources Information Center

    Nelson, Julie D.

    2016-01-01

    Rhetoric and composition scholars' almost exclusive reliance on Brian Massumi's definition of affect has spurred a theoretical and practical divorce between "affect" and "emotion" in our field. This article returns to Lynn Worsham's "Going Postal" and argues that to fully scrutinize and respond to what she calls…

  5. Academic Pipeline and Futures Lab

    DTIC Science & Technology

    2016-02-01

    AFRL-RY-WP-TR-2015-0186 ACADEMIC PIPELINE AND FUTURES LAB Brian D. Rigling Wright State University FEBRUARY 2016...DD-MM-YY) 2. REPORT TYPE 3. DATES COVERED (From - To) February 2016 Final 12 June 2009 – 30 September 2015 4. TITLE AND SUBTITLE ACADEMIC ...6 3 WSU ACADEMIC PIPELINE AND LAYERED SENSING FUTURES LAB (prepared by K

  6. The Incompatibility of Science and Religion Sustained: A Reply to Our Critics.

    ERIC Educational Resources Information Center

    Mahner, Martin; Bunge, Mario

    1996-01-01

    Replies to a number of criticisms by Tom Settle, Hugh Lacey, Michael Poole, Brian Woolnough, John Wren-Lewis, and Harold Turner in a series of comments on the authors' paper entitled "Is Religious Education Compatible with Science Education?" Offers counterarguments and clarifies certain misunderstandings to show that these criticisms…

  7. Education Policy: Explaining, Framing and Forming

    ERIC Educational Resources Information Center

    Adams, Paul

    2016-01-01

    This paper presents a new heuristic device for the analysis of educational policy. Through an examination of the Evaluative State and the work of Brian Fay, the paper considers the way in which educational policy is subject to rational and linear forms of policy action and implementation. To counter this, positioning theory is deployed to consider…

  8. Determining adaptive and adverse oxidative stress responses in human bronical epithelial cells exposed to zinc

    EPA Science Inventory

    Determining adaptive and adverse oxidative stress responses in human bronchial epithelial cells exposed to zincJenna M. Currier1,2, Wan-Yun Cheng1, Rory Conolly1, Brian N. Chorley1Zinc is a ubiquitous contaminant of ambient air that presents an oxidant challenge to the human lung...

  9. Models of Music Therapy Intervention in School Settings

    ERIC Educational Resources Information Center

    Wilson, Brian L., Ed.

    2002-01-01

    This completely revised 2nd edition edited by Brian L. Wilson, addresses both theoretical issues and practical applications of music therapy in educational settings. 17 chapters written by a variety of authors, each dealing with a different setting or issue. A valuable resource for demonstrating the efficacy of music therapy to school…

  10. Sir Gawain Was Just Out of Middle School....

    ERIC Educational Resources Information Center

    Probst, Robert E.

    2002-01-01

    Notes that what all middle school students need is another kid like them but with words. Presents some examples of adolescents going through the rites of passage--someone like T.J. in Chris Crutcher's "Whale Talk," or Sara Louise Bradshaw in Katherine Paterson's "Jacob Have I Loved," or Brian in Gary Paulson's…

  11. 76 FR 9345 - Brian Hunter; Third Supplemental Notice of Designation of Commission Staff

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ...; Third Supplemental Notice of Designation of Commission Staff On February 1, 2008, the Commission issued an order that, inter alia, designated the staff of the Office of Enforcement as non- decisional in... Financial Regulation. On May 6, 2008, in a Supplemental Notice of Designation of Commission Staff, Shauna...

  12. DEVELOPMENT OF A 950-GENE DNA ARRAY FOR EXAMINING GENE EXPRESSION PATTERNS IN MOUSE TESTIS

    EPA Science Inventory

    Development of a 950-gene DNA array for examining gene expression patterns in mouse testis.

    Rockett JC, Christopher Luft J, Brian Garges J, Krawetz SA, Hughes MR, Hee Kirn K, Oudes AJ, Dix DJ.

    Reproductive Toxicology Division, National Health and Environmental Effec...

  13. Implementing No Child Left Behind in Three States. Research Brief

    ERIC Educational Resources Information Center

    Stecher, Brian M.; Epstein, Scott; Hamilton, Laura S.; Marsh, Julie A.; Robyn, Abby; McCombs, Jennifer Sloan; Russell, Jennifer; Naftel, Scott

    2008-01-01

    This research brief describes work done for RAND Education and documented in "Pain and Gain: Implementing No Child Left Behind in Three States, 2004-2006", Brian M. Stecher, Scott Epstein, Laura S. Hamilton, Julie A. Marsh, Abby Robyn, Jennifer Sloan McCombs, Jennifer Russell, and Scott Naftel." The three states discussed are:…

  14. An improved method for collecting and monitoring pine oleoresin

    Treesearch

    Dick Karsky; Brian Strom; Harold Thistle

    2004-01-01

    A new method for collecting and monitoring pine oleoresin has been developed through a cooperative project involving the Missoula Technology Development Center (MTDC), Southern Research Station (Brian Strom, research entomologist), and the Forest Health Technology Enterprise Team. The new sampling unit (figure 1) is cast from rugged plastic. It provides a closed system...

  15. 75 FR 11895 - National Institute of General Medical Sciences; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... confidential trade secrets or commercial property such as patentable material, and personal information... Sciences Special Emphasis Panel, Modeling the Scientific Workforce. Date: April 5, 2010. Time: 1 p.m. to 3..., Natcher Building, 45 Center Drive, Room 3AN.34, Bethesda, MD 20892. Contact Person: Brian R. Pike, PhD...

  16. A Center for Advanced Electrical and Structural Polymers

    DTIC Science & Technology

    1988-10-31

    REPORT I 3b. TIME COVERED 14. DATE OF REPORT (Year, Month, Oay) IS. PAGE COUNT Final j FROM TO 44 16. SUPPLEMENTARY NOTATION 17. COSATI CODES 18...Banhegyi Dr. N. Easwar Dr. Z. Chai Dr. K. Liang Dr. S. Choe Dr. G. Smyth Dr. P. Cifra Dr. J . Kim Dr. W. Huh Dr. Q. Bhatia Dr. J . Grobelny Dr. P... J . Chen (WSU) Dr. G. Quin Dr. M. Sinksy (WSU) Dr. N. Segudovic Dr. R. Miller (WSU) Dr. G. Shy Dr. Y. Gur Mr. L. Wu Dr. T. Bleha Dr. A. Sikora Dr. H

  17. COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis

    PubMed Central

    Aich, Abhishek; Wang, Cong; Chowdhury, Arpita; Ronsör, Christin; Pacheu-Grau, David; Richter-Dennerlein, Ricarda; Dennerlein, Sven

    2018-01-01

    Cytochrome c oxidase of the mitochondrial oxidative phosphorylation system reduces molecular oxygen with redox equivalent-derived electrons. The conserved mitochondrial-encoded COX1- and COX2-subunits are the heme- and copper-center containing core subunits that catalyze water formation. COX1 and COX2 initially follow independent biogenesis pathways creating assembly modules with subunit-specific, chaperone-like assembly factors that assist in redox centers formation. Here, we find that COX16, a protein required for cytochrome c oxidase assembly, interacts specifically with newly synthesized COX2 and its copper center-forming metallochaperones SCO1, SCO2, and COA6. The recruitment of SCO1 to the COX2-module is COX16- dependent and patient-mimicking mutations in SCO1 affect interaction with COX16. These findings implicate COX16 in CuA-site formation. Surprisingly, COX16 is also found in COX1-containing assembly intermediates and COX2 recruitment to COX1. We conclude that COX16 participates in merging the COX1 and COX2 assembly lines. PMID:29381136

  18. Diabetes prevention program in a Mediterranean environment: individual or group therapy? An effectiveness evaluation.

    PubMed

    Endevelt, R; Peled, R; Azrad, A; Kowen, G; Valinsky, L; Heymann, A D

    2015-04-01

    Diabetes as a multifactorial disorder requires prevention measures based upon the modification of several risk factors simultaneously; otherwise, there is insufficient potential for prevention. Following the success of the American Diabetes Prevention Program (DPP), we implemented an intervention program in a large Israeli healthcare organization with an emphasize on Mediterranean Diet (MedDiet) and physical activity. The objective was to evaluate the effectiveness of two types of intervention, individual and group therapies, in reducing risk factors and in preventing or delaying the development of type 2 diabetes. Out of 180 primary care physicians, 85 who agreed to participate, were randomly assigned, between the years 2005 and 2006, into two groups: those who would refer pre-diabetes adult patients for individual therapy and those who would refer for group therapy. The two groups of patients consisted of 111 and 112 in each group. The intervention lasted for 6 months and discussed: the benefits of MedDiet, planning nutritional behavior and mindful eating, and the importance of physical activity. All patients were invited to participate in walking groups. Follow up lasted for 24 months and logistic, mixed models, and Cox regressions were employed. No statistically significant differences were detected between the two intervention groups in age; gender and clinical measurements at recruitment. Thirty nine percent of both groups developed diabetes (entered the DR by 2012), including 38.7% from the individual therapy and 39.3% from the group therapy (P=0.933). The mean time from 2005 until entry to the Diabetes Registry (DR) was 2.9 and 2.5 years for the individual and group therapy respectively (P=0.542). Both interventions were equally effective in achieving the desired outcomes and time until entry to the DR. For large health organizations with a high number of pre-diabetes patients and scarce resources, group therapy, where 12 people are reached out by one team member are preferable and more costly effective, than a one on one therapy. Copyright © 2014 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

  19. Palonosetron versus older 5-HT3 receptor antagonists for nausea prevention in patients receiving chemotherapy: a multistudy analysis.

    PubMed

    Morrow, Gary R; Schwartzberg, Lee; Barbour, Sally Y; Ballinari, Gianluca; Thorn, Michael D; Cox, David

    2014-07-01

    No clinical standard currently exists for the optimal management of nausea induced by emetogenic chemotherapy, 7particularly delayed nausea. To compare the effcacy and safety of palonosetron with older 5-HT3 receptor antagonists (RAs) in preventing chemotherapy-induced nausea. Data were pooled from 4 similarly designed multicenter, randomized, double-blind, clinical trials that compared single intravenous doses of palonosetron 0.25 mg or 0.75 mg with ondansetron 32 mg, dolasetron 100 mg, or granisetron 40 μg/kg, administered 30 minutes before moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC). Pooled data within each chemotherapy category (MEC: n = 1,132; HEC: n = 1,781) were analyzed by a logistic regression model. Nausea endpoints were complete control rates (ie, no more than mild nausea, no vomiting, and no rescue medication), nausea-free rates, nausea severity, and requirement for rescue antiemetic/antinausea medication over 5 days following chemotherapy. Pooled safety data were summarized descriptively. Numerically more palonosetron-treated patients were nausea-free on each day, and fewer had moderate-severe nausea. Similarly, usage of rescue medication was less frequent among palonosetron-treated patients. Complete control rates for palonosetron and older 5-HT3 RAs in the acute phase were 66% vs 63%, 52% vs 42% in the delayed phase (24-120 hours), and 46% vs 37% in the overall phase. The incidence of adverse events was similar for palonosetron and older 5-HT3 RAs. This post hoc analysis summarized data for palonosetron and several other 5-HT3 RAs but was not powered for statistical comparisons between individual agents. Because nausea is inherently subjective, the reliability of assessments of some aspects (eg, severity) may be infuenced by interindividual variability. Palonosetron may be more effective than older 5-HT3 RAs in preventing nausea, with comparable tolerability. Dr Schwartzberg is a consultant to and Dr Cox an employee at Esai. Mr Ballinari is a member of staff at and Dr Thorn consults for Helsinn Healthcare SA. Funding to support this study and the preparation of this manuscript was provided by Eisai Inc. 2014 FrontlineMedical Communications.

  20. Obituary: Brian Marsden (1937-2010)

    NASA Astrophysics Data System (ADS)

    Williams, Gareth; Marsden, Cynthia

    2011-12-01

    Brian Geoffrey Marsden was born on 1937 August 5 in Cambridge, England. His father, Thomas, was the senior mathematics teacher at a local high school. It was his mother, Eileen (nee West), however, who introduced him to the study of astronomy, when he returned home on the Thursday during his first week in primary school in 1942 and found her sitting in the back yard watching an eclipse of the sun. Using now frowned-upon candle-smoked glass, they sat watching the changing bite out of the sun. What most impressed the budding astronomer, however, was not that the eclipse could be seen, but the fact that it had been predicted in advance, and it was the idea that one could make successful predictions of events in the sky that eventually led him to his career. When, at the age of 11, he entered the Perse School in Cambridge he was developing primitive methods for calculating the positions of the planets. He soon realized that earlier astronomers had come up with more accurate procedures for doing this over the centuries, and during the next couple of years this led to his introduction to the library of the Cambridge University Observatories and his study of how eclipses, for example, could be precisely computed. Together with a couple of other students he formed a school Astronomical Society, of which he served as the secretary. At the age of 16 he joined and began regularly attending the monthly London meetings of the British Astronomical Association. He quickly became involved with the Association's Computing Section, which was known specifically for making astronomical predictions other than those that were routinely being prepared by professional astronomers for publication in almanacs around the world. Under the watchful eyes of the director and assistant director of the Computing Section, this led him to prepare and publish predictions of the occasions when one of Jupiter's moons could be seen to pass directly in front of another. He also calculated the gravitational effects of the planets on the dates and sky positions of the returns of some periodic comets. He carried out these computations using seven-place logarithms. After all, this was long before pocket calculators had been invented, and the construction of large electronic computers was still then very much in its infancy. He always maintained that making such computations by primitive means significantly increased one's understanding of the science involved. During his last year of high school he also became a junior member of the Royal Astronomical Society. He was an undergraduate at New College, University of Oxford. In his first year there he persuaded the British Astronomical Association to lend him a mechanical calculating machine, allowing him thereby to increase his computational productivity. By the time he received his undergraduate degree, in mathematics, he had already developed somewhat of an international reputation for the computation of orbits of comets, including new discoveries. He spent part of his first two undergraduate summer vacations working at the British Nautical Almanac Office. He also responded to an inquiry from Dorothy L. Sayers involving the ancient Roman poet Lucan. Incensed by what she perceived as grossly unfair criticism of Lucan by A. E. Housman and Robert Graves, she elicited his assistance during the last year of her life to support her view that Lucan's understanding of astronomy and geography was reasonably valid. Dr. Sayers' extensive correspondence in the course of this study is included in the last volume of her collected letters. After Oxford, he took up an invitation to cross the pond and work at the Yale University Observatory. He had originally planned to spend just a year there carrying out research on orbital mechanics, but on his arrival in 1959 he was also enrolled as a Yale graduate student. With the ready availability of the university's IBM 650 computer in the observatory building, he had soon programmed it to compute the orbits of comets. Recalling his earlier interest in Jupiter's moons, he completed the requirements for his Ph.D. degree with a thesis on "The Motions of the Galilean Satellites of Jupiter". At the invitation of director Fred Whipple, he joined the staff of the Smithsonian Astrophysical Observatory in Cambridge (MA) in 1965. Dr. Whipple was probably best known for devising the "dirty snowball" model for the nucleus of a comet a decade and a half earlier. At that time there was only rather limited evidence that the motion of a comet was affected by forces over and above those of gravitation (limited because of the need to compute the orbit by hand), and the Whipple model had it that those forces were due to the comet's reaction to vaporization of the cometary snow or ice by solar radiation. Dr. Marsden therefore developed a way to incorporate such forces directly into the equations that governed the motion of a comet. Application of a computer program that included these nongravitational effects to several comets soon gave results that were nicely compatible with Dr. Whipple's original idea. Continued refinement of the nongravitational terms, much of it done in collaboration with Zdenek Sekanina, a Czech astronomer and friend of Dr. Marsden whom he and Dr. Whipple succeeded in bringing to the U.S. as a refugee following the Soviet invasion of Prague in 1968, resulted in a wealth of improved computations of cometary orbits by the time Dr. Sekanina moved to California in 1980. It is noteworthy that the procedure devised and developed by Dr. Marsden is still widely used to compute the nongravitational effects of comets, with relatively little further modification by other astronomers. The involvement of the Smithsonian Astrophysical Observatory with comets had been given a boost, shortly before Dr. Marsden's arrival there, by the transfer there from Copenhagen of the office of the Central Bureau for Astronomical Telegrams, a quaintly named organization that was established by the International Astronomical Union soon after its founding in 1920. The CBAT is responsible for disseminating information worldwide about the discoveries of comets, novae, supernovae and other objects of generally transient astronomical interest. It is the CBAT that actually names the comets (generally for their discoverers), and it has also been a repository for the observations of comets to which orbit computations need to be fitted. Dr. Marsden succeeded Dr. Owen Gingerich as the CBAT director in 1968. He was joined by Daniel Green as a student assistant a decade later, and Dr. Green took over as CBAT director in 2000. Until the early 1980s the Bureau really did receive and disseminate the discovery information by telegram (with dissemination also by postcard Circular), although e-mail announcements then understandably began to take over. The last time the CBAT received a telegram was when Thomas Bopp sent word of his discovery of a comet in 1995. Since word of this same discovery had already been received from Alan Hale a few hours earlier by e-mail, the object was very nearly just named Comet Hale, rather than the famous Comet Hale-Bopp that beautifully graced the world's skies for several weeks two years later. The comet prediction of which he was most proud was of the return of comet Swift-Tuttle, which is the comet associated with the Perseid meteors each August. It had been discovered in 1862, and the conventional wisdom was that it would return around 1981. He followed that line for much of a paper he published on the subject in 1973. He had a strong suspicion, however, that the 1862 comet was identical with one seen in 1737, and this assumption allowed him to predict that Swift-Tuttle would not return until late-1992. This prediction proved to be correct, and this comet has the longest orbital period of all the comets whose returns have been successfully predicted. Although the CBAT also traditionally made announcements of the discoveries of asteroids that came close to the earth, the official organization for attending to discoveries of asteroids (more than 99% of which are located in a belt between Mars and Jupiter) is the Minor Planet Center. Also operated by the International Astronomical Union, the MPC was located until 1978 at the Cincinnati Observatory. In that year the director, Dr. Paul Herget, was retiring, and it was necessary for the Center to find a new home. Accordingly, the IAU asked Dr. Marsden also to take over the direction of the MPC. Thanks to the transfer of associate director Conrad Bardwell with the MPC records from Cincinnati, this task was rendered easier. While the CBAT and the MPC still maintained their separate entities, there was a lot of common ground between them. Dr. Marsden was therefore able to introduce some efficiencies into their combined operation. On Mr. Bardwell's retirement at the end of 1989, Gareth Williams joined the MPC staff and later became associate director. The advances in electronic communication during the 1990s also permitted improvements in MPC operation. Perhaps the most important of these was the development, in 1996, of the Internet "Near-Earth Object Confirmation Page". This draws attention to candidate earth-approaching objects in need of follow-up observations as soon as they have been reported to the MPC, following the derivation by Dr. Marsden of a particularly ingenious method for estimating the uncertainty of the prediction by automatically computing a series of orbits that represent just the first and the last observations. In 1998 he developed a certain amount of notoriety by suggesting that an object called 1997 XF11 could collide with the earth. He did this as a last-ditch effort to encourage the acquisition of further observations, including searches for possible data from several years earlier. The recognition of some observations from 1990 made it quite clear that there could be no collision with 1997 XF11 during the foreseeable future. Without those 1990 observations, however, the object's orbit would have become very uncertain following a close to moderate approach to the earth in 2028; indeed, Dr. Marsden correctly demonstrated that there was the possibility of an earth impact in 2040 and in several neighboring years. He was thereby able eventually to persuade his principal critics routinely to perform similar uncertainty computations for all near-earth objects as they were announced. Again, as more data accrue, it is almost certain to happen that all possible impacts with moderately large objects (i.e., those at least several hundred feet across) during the next century, say, will disappear. While the production of such computations was directly due to his encouragement, it was always with some amusement that he saw cases where further data forced his former critics sheepishly to withdraw their earlier frightening statements about a potentially dangerous object. Dr. Marsden was particularly fascinated by the appearance of a group of comets that passed close to the sun. Known as members of the Kreutz group, after a German astronomer who studied them in the late nineteenth century, the discovery of three more of these sungrazing comets in the mid-twentieth century led him to undertake a detailed examination of how the individual comets may have evolved from each other. He published this examination in 1967, following it up with a further study in 1989 involving a more recent bright Kreutz comet, as well as several much fainter objects that had been detected from sun-observing coronagraphs out in space. Beginning in 1996, these were being found by the SOHO coronagraphs at rates ranging from a few dozen to more than one hundred per year. Unfortunately, the faintness of the comets and the poor accuracy with which they could be measured made it difficult to establish their orbits as satisfactorily as Dr. Marsden would have liked. More significantly, however, he was able to recognize that the SOHO data also contained another group of comets with similar orbits, these comets now known as members of the "Marsden group". Unlike the individual Kreutz comets, which have orbital periods of several centuries, it seems that the Marsden comets have orbital periods of only five or six years, leading him to try and recognize the same object at different passages near the sun and thereby predict future returns. Two other well-populated groups have also been detected in the SOHO data. Another series of astronomical discoveries that greatly interested him were what he always called the "transneptunian objects", although many of his colleagues have insisted on calling them "objects in the Kuiper Belt". When what those same colleagues considered to be the first of these was discovered in 1992, Dr. Marsden immediately remarked that this was untrue, because Pluto, discovered in 1930 and admittedly somewhat larger in size, had to be the first. More specifically, he was the first to suggest, correctly, that three further transneptunian objects discovered in 1993 were exactly like Pluto in the sense that they all orbit the sun twice while Neptune orbits it thrice. This particular recognition set him firmly on the quest to "demote" Pluto. Success required the discovery of transneptunian objects more comparable to Pluto in size, something that finally happened in 2005 with the discovery of the object that came to be known as Eris. At its triennial meeting in 2006 in Prague, the IAU voted to designate these objects, together with two further transneptunian objects now known as Makemake and Haumea, as well as the largest asteroid, Ceres, members of a new class of "dwarf planet". It was also at the IAU meeting in Prague that Dr. Marsden stepped down as MPC director, and he was quite entertained by the thought that both he and Pluto had been retired on the same day. While he remained working at the MPC (and also the CBAT) in an emeritus capacity, the directorship was passed to Dr. Timothy Spahr, whom he had brought to the MPC in 2000. Dr. Marsden served as an associate director of the Harvard-Smithsonian Center for Astrophysics (the combination of the Smithsonian Astrophysical Observatory and the Harvard College Observatory) for 15.75 years from the beginning of 1987 (the longest tenure for any of the Center's associate directors). He was chair of the Division of Dynamical Astronomy of the American Astronomical Society during 1976-1978 and president of the IAU commissions that oversaw the operation of the minor Planet Center (1976-1979) and the Central Bureau for Astronomical Telegrams (2000-2003). He continued to serve subsequently on the two solar-system nomenclature committees of the IAU, being the perennial secretary of the one that decides on names for asteroids. He also continued to publish a "Catalogue of Cometary Orbits," the first of these having appeared in 1972 and its successors roughly at intervals of two years. Among the various awards he received from the U.S., the U.K. and a handful of other European countries, the ones he particularly appreciated were the 1995 Dirk Brouwer Award (named for his mentor at Yale) of the AAS Division on Dynamical Astronomy and the 1989 Van Biesbroeck Award (named for an old friend and observer of comets and double stars), then presented by the University of Arizona, now by the AAS, for service to astronomy. Dr. Marsden married Nancy Lou Zissell, of Trumbull, Connecticut, on 1964 December 26, and fathered Cynthia (who is married to Gareth Williams, still MPC associate director), of Arlington, Massachusetts; and Jonathan, of San Mateo, California. There are three Californian grandchildren, Nikhilas, Nathaniel and Neena. A sister, Sylvia Custerson, continues to reside in Cambridge, England. From material written by Brian Marsden, edited by Gareth Williams, Cynthia Marsden, and HAD. First posted by the Minor Planet Center on 18 November 2010 as Minor Planet Electronic Circular 2010-W10.

  1. Emerging Technologies Program Integration Report. Volume 1. Narrative, Analyses and Assessment

    DTIC Science & Technology

    1987-05-04

    James S. (T) 31. GREGG, Dr. Michael C. (T) 61. REDDY, Dr. Raj (T) 2. ATLAS, Dr. David (T) 32. HADDAD, Dr. Genevieve M. 62. REDIKER, Dr. Robert H. 3...Dr. Martin C. 83. WEEKS, Dr. Wilford 6 24. FAETH, Dr. Gerald 54. MUNSON, Mr. John 84. WEINTRAUB, Dr. Daniel 1. (T) 25. FETTERMAN , Dr. Harold 55...T) 2. ATLAS, Dr. David (T) 32. HADDAD, Dr. Genevieve M. 62. REDIKER, Dr. Robert H. 3. BALDESCHWIELER, Dr. John (T) 33. HAMMOND, Dr. George S. 63

  2. "I Know Your Father Very, Very Well"

    ERIC Educational Resources Information Center

    Talbott, Brian L., II

    2012-01-01

    Many a young boy wishes to grow up to be like his father someday. The author's father, Brian L. Talbott, was named superintendent of Educational Service District 105 in Yakima, Washington, the same year he entered 1st grade. He continued in this position through his elementary years. His stomping grounds changed during the summer between 6th and…

  3. The National Research Center on the Gifted and Talented (NRC/GT) Newsletter, June 1991-Winter 1997.

    ERIC Educational Resources Information Center

    Gubbins, E. Jean, Ed.; Siegle, Del L., Ed.

    1997-01-01

    These 15 newsletters from the National Research Center on the Gifted and Talented (NRC/GT) contain the following articles: (1) "National Research Needs Assessment Process" (Brian D. Reid); (2) "NRC/GT: Update of Year 2 Activities" (E. Jean Gubbins); (3) "Parents: Their Impact on Gifted Adolescents" (Julie L. Sherman);…

  4. Dynamics of Interagency Cooperation Process at Provincial Reconstruction Team in Operations ISAF and Enduring Freedom

    DTIC Science & Technology

    2010-06-11

    Carlisle, PA, 2007. Lovelace Jr, Douglas C., Richard A Chilcoat, Jay W Boggs, Dennis C Jett, John F Troxell, H Allen Irish, Joseph J Collins, Carlos...Hernandorena, Katherine Rogers, 102 Patrick B Baetjer, James J Wirtz, Scott R Feil, Robert B Polk, Amanda Smith, Robert H Dorff, James M Smith, Brian

  5. NASA in the Park, 2018

    NASA Image and Video Library

    2018-06-20

    NASA in the Park on June 16 in Huntsville featured more than 60 exhibits and demonstrations by NASA experts, as well as performances by Marshall musicians, educational opportunities, games and hands-on activities for all ages. Brian Mitchell of Marshall’s Planetary Mission Planning Office gives attendees an opportunity to learn about Science missions managed by his office.

  6. 78 FR 40101 - Certain Tissue Paper Products from the People's Republic of China: Affirmative Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... CONTACT: Brian Smith or Gemal Brangman, AD/CVD Operations, Office 2, Import Administration, International... Antidumping Duty Order'' section, which are produced in India from PRC-origin jumbo rolls and/or cut sheets of tissue paper, and exported from India to the United States. This inquiry only covers such PRC-origin...

  7. 78 FR 78477 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ...) Duane C. Conway (NV) Ronald L. Cote (NV) Brian W. Curtis (IL) Albion C. Doe, Sr. (NH) Robin C. Duckett.... Gartin (OH) Dale L. Giardine (PA) Leslie W. Good (OR) Chester L. Gray (TX) Christian L. Gremillion (LA.... Weinert (NY) Joseph A. Wells (IL) Don S. Williams (VA) Robert L. Williams, Jr. (MS) Kevin W. Wunderlin (OH...

  8. 76 FR 70212 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    .... Hershberger Patrick J. Hogan, Jr. Todd A. McBrian Amilton T. Monteiro Harold W. Mumford John W. Myre David G. Oakley Charles D. Oestreich John S. Olsen Thomas J. Prusik Brent L. Seaux Glen W. Sterling The exemptions.... Bequeaith Lloyd K. Brown Larry Chinn Kecia D. Clark-Welch Tommy R. Crouse Ben W. Davis Charles A. DeKnikker...

  9. 77 FR 40946 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    .... Almeida (MA) Ronald B. Brown (ME) Trixie L. Brown (IN) Thomas L. Corey (IN) Brian G. Hagen (IL) Azizi A. Jamal (NJ) Willard L. Riggle (IN) Jose M. Suarez (TX) Lee F. Taylor (NJ) Barney J. Wade (MS) Richard G. Wendt (MS) Charles A. Winchell (OK) The exemptions are extended subject to the following conditions: (1...

  10. 76 FR 39645 - Exemptions for Advisers to Venture Capital Funds, Private Fund Advisers With Less Than $150...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ... FURTHER INFORMATION CONTACT: Brian McLaughlin Johnson, Tram N. Nguyen or David A. Vaughan, at (202) 551..., 100 F Street, NE., Washington, DC 20549-8549. SUPPLEMENTARY INFORMATION: The Commission is adopting... States 4. United States Person C. Foreign Private Advisers 1. Clients 2. Private Fund Investor 3. In the...

  11. Seconds Before Disaster. Air Force Civil Engineer, Volume 14, Number 1, 2006

    DTIC Science & Technology

    2006-01-01

    initiative—RED HORSE Way Ahead—to ensure that RH remains viable and relevant in the future. “We are taking what was previously 10 [unit type codes ...Hilary S. Edwards Brian A. Field David A. Frasier Robbin C. Freeberg Isaias S. Garza Lawrence R. Greebon William D. Grimes Duane S. Grubbs Danny D

  12. Changing Hearts and Minds: The Quest for Open Talk about Race in Educational Leadership

    ERIC Educational Resources Information Center

    Rusch, Edith A.; Horsford, Sonya Douglass

    2009-01-01

    Purpose: The purpose of this paper is to seek to conceptualize a theory of self-contribution as a framework for understanding and demonstrating the dispositions and skills academics and educational leaders need to break the silence and engage in constructive talk about race across color lines. Design/methodology/approach: Brian Fay's framework for…

  13. Teacher Evaluation: Alternate Measures of Student Growth. Q&A with Brian Gill. REL Mid-Atlantic Webinar

    ERIC Educational Resources Information Center

    Regional Educational Laboratory Mid-Atlantic, 2013

    2013-01-01

    This webinar described the findings of our literature review on alternative measures of student growth that are used in teacher evaluation. The review focused on two types of alternative growth measures: statistical growth/value-added models and teacher-developed student learning objectives. This Q&A addressed the questions participants had…

  14. Air Force Fixed-Wing Rescue: A Multifaceted Approach for Full-Spectrum Personnel Recovery

    DTIC Science & Technology

    2011-01-01

    to the author, e-mail, 29 June 2011. The cost per flying hour is in fiscal year 2011 constant dollars. 11. Ibid.; and Lt Col Brian Pitcher ...personnel could provide maintenance support for one or several small aircraft. This assumes fully trained and licensed air- frame and power- plant mechanics

  15. 77 FR 49789 - Record of Decision for Issuing a Presidential Permit to Energia Sierra Juarez U.S. Transmission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    .... Transmission Line EIS, contact Brian Mills as indicated in the ADDRESSES section above. For general information... Executive Order (E.O.) 10485 (September 9, 1953), as amended by E.O. 12038 (February 7, 1978), requires that... California State Historic Preservation Officer (SHPO) regarding potential impacts on historic properties, as...

  16. A Platform for Antenna Optimization with Numerical Electromagnetics Code Incorporated with Genetic Algorithms

    DTIC Science & Technology

    2006-03-01

    have been the concentration of many literature compositions [12, 30, 38, 39, 49, 53]. Van Veldhuizen et. al. [53] improved the geometries of wire...Electric Waves”. J. IEE (Japan), volume 47, 273–282. March 1926. 53. Veldhuizen , David A. Van , Brian S. Sandlin, Rober E. Marmelstein, Gary B. Lam- ont, and

  17. Young People Drawn to Aid in 2008 Race

    ERIC Educational Resources Information Center

    Klein, Alyson

    2008-01-01

    The scene in Brian Griffin's bedroom looks like a cross between a charity telethon and an intense cramming session the night before a final exam. Mr. Griffin and about 10 of his classmates--fellow members of the Plainfield High School (Indiana) chapter of Students for Barack Obama--are sprawled around the room, cellphones in hand, studying voter…

  18. - Domestic Vessels « Coast Guard Maritime Commons

    Science.gov Websites

    other commercial vessel regulations. 2/20/2018: Marine Safety Alert 2-18 Operational risk management , planning is essential to safe towing and salvage operations Marine Safety Alert 2-18 is issued to remind member, National Transportation Safety Board, and Mr. Brian Curtis, with NTSB's Office of Marine Safety

  19. VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY VIEW OF 2401 PIEDMONT, ALPHA EPSILON PHI HOUSE BY RATCLIFF & RATCLIFF, 1958. SEEN FROM NW CORNER LOOKING SE. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  20. Who's in the Mirror?: Issues Surrounding the Identity Construction of Music Educators

    ERIC Educational Resources Information Center

    Roberts, Brian

    2004-01-01

    The article presents the text of a guest lecture delivered at Richland College in Dallas, Texas, in April 2003, by Brian A. Roberts, professor of music education at the Memorial University of Newfoundland. Speaking to an audience of music education students, he discusses his ongoing research of the identity construction of music educators (do they…

  1. A Game Theoretic Model for the Optimal Disposition of Integrated Air Defense System Assets

    DTIC Science & Technology

    2015-03-26

    fellows of Miami Valley Philosophical and Lifting Society v Acknowledgements I want to thank LTC Brian J. Lunday and Lt Col Matthew J. Robbins for...on the defender’s valuation of tar- gets. However, if we assume that Hamas, the attacker, knows the layout of Israel’s defense, they may attack

  2. Cal State-Long Beach Heeds Call to Investigate Professors' Online Biographies

    ERIC Educational Resources Information Center

    Bartlett, Thomas

    2008-01-01

    This article reports that an essay by a film professor at California State University at Long Beach that questions the credentials of his colleagues is stirring controversy on the campus--and sparking investigations. The essay, written by Brian Alan Lane, an associate professor of film, accuses three of his colleagues in the department of film and…

  3. Professional Development for Transformational Technology Integration: An Experimental Study of In-Service Teachers' Self-Perceptions of Technological Pedagogical and Content Knowledge

    ERIC Educational Resources Information Center

    Tachau, Elena M.

    2017-01-01

    Professional Development for Transformational Technology Integration: An Experimental Study of In-Service Teachers' Self-Perceptions of Technological Pedagogical and Content Knowledge Elena M. Tachau Drexel University Chairperson: Brian K. Smith, Ph.D. The rapid advancement of technology tasks K-12 schools with providing professional development…

  4. Selected Papers from the International Conference on College Teaching and Learning (14th, Jacksonville, Florida, April 1-5, 2003).

    ERIC Educational Resources Information Center

    Chambers, Jack A., Ed.

    This collection of conference papers includes: "Building a Pedagogical Model for Synchronous Distance Learning Courses" (Panagiotes S. Anastasiades); "Delivery of Courseware using CD-ROM Media" (Brian Brighouse and Denis Edgar-Nevill); "Lessons Learned from Blended Biology Classes" (Arthur L. Buikema, Jr.); "Everything I Ever Needed to Know I…

  5. For Liability Purposes, Is a Student Worker an Employee?

    ERIC Educational Resources Information Center

    Franke, Ann H.

    2008-01-01

    Brian Lindsay, a chemistry major, participated in a summer research program at St. Olaf College. The 10-week program required him to work in a laboratory under the direction of a chemistry professor. Lindsay received a $3,500 stipend and free housing. On July 11, 2002, he was performing a procedure to clean, or "quench," a flask. The…

  6. Aerial Application of Acetaminophen treated Baits for Control of Brown Treesnakes

    DTIC Science & Technology

    2016-01-22

    Brian S. Dorr USDA/ Wildlife Services/National Wildlife Research Center, Starkville, MS Craig S. Clark USDA/ Wildlife Services, Honolulu, HI...Pete Savarie USDA/ Wildlife Services/National Wildlife Research Center, Ft. Collins, CO Distribution Statement A...7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER USDA/ Wildlife Services/National Wildlife

  7. 2016 Emerging Technology Domains Risk Survey

    DTIC Science & Technology

    2016-04-05

    2016 Emerging Technology Domains Risk Survey Christopher King Dan Klinedinst Todd Lewellen Garret Wassermann April 2016 TECHNICAL REPORT...Unlimited [Checkoway 2011] Checkoway, Stephen; McCoy, Damon; Kantor, Brian; Anderson, Danny; Shacham, Hovav; Savage, Stefan. Comprehensive Experimental ...Koscher 2010] Koscher, Karl et al. “ Experimental Security Analysis of a Modern Automobile,” 447-462. IEEE Symposium on Security and Privacy

  8. VALE: Rereading "Personal Response": A Reflection on the Contribution of Annette Patterson

    ERIC Educational Resources Information Center

    Moon, Brian

    2017-01-01

    Looking back now on the contribution of Annette Patterson, to whom this issue of "English in Australia" is dedicated, Brian Moon states that, "he is reminded not only of her intelligence and her capacity for independent thought and inquiry, but also of her courage in questioning some powerful orthodoxies in English education."…

  9. THE EFFECTS OF HYPERTHERMIA ON SPERMATOGENESIS, APOPTOSIS, GENE EXPRESSION AND FERTILITY IN ADULT MALE MICE

    EPA Science Inventory

    The effects of hyperthermia on spermatogenesis, apoptosis, gene expression and fertility in adult male mice
    John C. Rockett1, Faye L. Mapp1, J. Brian Garges1, J. Christopher Luft1, Chisato Mori2 and David J. Dix1.
    1Reproductive Toxicology Division, National Health and Envir...

  10. 76 FR 42055 - Data Availability Concerning Transport Rule Allowance Allocations to Existing Units

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 97 [FRL-9435-6] Data Availability Concerning Transport... concerning this action should be addressed to Brian Fisher, telephone (202) 343-9633, and e- mail fisher.... 97.411(a)(2), 97.511(a)(2), 97.611(a)(2), and 97.711(a)(2) (concerning termination of allocations of...

  11. VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY. SEEN FROM SW CORNER TOWARDS 2395 PIEDMONT, SIGMA PI HOUSE BY FREDERICK H. REIMERS, 1928. LOOKING NORTH. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  12. Pacific Armies Management Seminar (5th) Held at manila, Republic of the Philippines on 16-20 November 1981.

    DTIC Science & Technology

    1981-01-01

    0. C. Admin Wing, Bashar (BAS) MAJ ENAYET Hussain, General Staff Officer, Operations Directorate, Army Headquarters LTC Hugh M. BAKER, US Defense...L. BUTCHER **LTC Ronald TURNER MAJ Hercules CATALUNA LTC Paul SOMR MAJ ENAYET Hussain MAJ Frederick DREW MAJ SHIN 11 Soon MAJ Brian HALL MAJ TAN Khin

  13. 78 FR 27961 - Gordon Foster and Seneca Falls School, Deep Creek Energy LLC; Notice of Transfer of Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 5991-003] Gordon Foster and Seneca Falls School, Deep Creek Energy LLC; Notice of Transfer of Exemption 1. By letter filed March 20, 2013, Mr. Brian Gogarty, Deep Creek Energy LLC informed the Commission that the exemption from...

  14. Altering Perspectives: How the Implied Reader Invites Us to Rethink the Difficulty of Graphic Novels

    ERIC Educational Resources Information Center

    Connors, Sean P.

    2012-01-01

    This article reports the author's experiences using graphic novels with pre-service teachers in a young adult literature course. Drawing on critical response papers two students composed after reading "Pride of Baghdad," a graphic novel by Brian K. Vaughan and Niko Henrichon, the author argues that when readers possess the background…

  15. "Simon Says": A Response from Two Nineteenth-Century Educators

    ERIC Educational Resources Information Center

    Hirsch, Pam; McBeth, Mark

    2004-01-01

    Writing in the early 1980s in his essay "Why no pedagogy in England?", Brian Simon alleged that "The dominant educational institutions of this country have had no concern with theory, its relation to practice, with pedagogy", and, as a result, pedagogy was regarded as "either undesirable or impossible of achievement". In Simon's essay he composes…

  16. A New Teacher's Plea

    ERIC Educational Resources Information Center

    Jones, Brian K.

    2012-01-01

    New teachers are often too overwhelmed by their new responsibilities to be the effective teachers they wish to be. Brian K. Jones, a new teacher who loves his job but still thinks of quitting at least once a month, says that teachers need a more comprehensive system of supports before and after they enter the classroom. Such a system would include…

  17. Interview with Brian Kearsey about the Founding of Crossroads School, Brewster, NY.

    ERIC Educational Resources Information Center

    Kearsey, Brian; Kearsey, Kathy

    2000-01-01

    A husband and wife team of Montessori-trained teachers started a private school in Brewster (New York) that also serves as a home school resource center. Their practices include mixed-age grouping, learner-centered instruction, optional standardized tests, parents in the classrooms, and frequent field trips. They endured 3 years of dealing with…

  18. Differing Views of Human Intelligence

    ERIC Educational Resources Information Center

    Chitty, Clyde

    2011-01-01

    This article is based on a talk that was given by the author at the Institute of Historical Research on 3 February 2011, on the Victorian polymath Francis Galton and the malign legacy of his eugenic theories. It pays tribute to the pioneering work of the late Brian Simon in challenging the whole idea of "fixed innate intelligence" and in…

  19. 77 FR 20097 - Intent To Prepare an Environmental Impact Statement for the Georgia Multi-Modal Passenger Terminal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-03

    ... Smart, Federal Transit Administration, 230 Peachtree Street NW., Suite 800, Atlanta, GA 30327. Telephone: 404-865-5607. Email: brian.smart@dot.gov . SUPPLEMENTARY INFORMATION: In accordance with Section 6002...-city, regional and local modal services. At the same time, the Gulch creates a large void in the...

  20. 78 FR 29325 - Prestressed Concrete Steel Rail Tie Wire From Mexico, the People's Republic of China, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ...] Prestressed Concrete Steel Rail Tie Wire From Mexico, the People's Republic of China, and Thailand: Initiation... (Mexico), Brian Smith (the People's Republic of China (the ``PRC'')), or Kate Johnson (Thailand) at (202... Prestressed Concrete Steel Rail Tie Wire from the People's Republic of China, Mexico, and Thailand...

  1. Operational Sequencing: Coping with Contingency in Process Drama

    ERIC Educational Resources Information Center

    Nielsen, Thomas Rosendal; Hustvedt, Kjersti

    2017-01-01

    In 1979, Gavin Bolton posed a question that is still fundamental to the development of process drama: "Is it possible to steer a course that does not come down in support of any particular point of view but causes children to examine and re-examine their own views and values?" Inspired by Bakhtinian theory, Brian Edmiston developed a…

  2. The Best Kept Secret in Gifted Education

    ERIC Educational Resources Information Center

    Alvino, James

    2004-01-01

    It is perhaps one of the best-kept secrets in educating gifted high school youth, and yet for 45 years, Hugh O'Brian Youth Leadership (HOBY) has been going strong, "Motivating Tomorrow's Leaders Today." After spending nine inspirational days in 1958 with Albert Schweitzer (Nobel Prize physician and philosopher) at his clinic in the African jungle,…

  3. When the War Doesn’t End: Detainees in Legal Limbo

    DTIC Science & Technology

    2014-05-01

    Kha led el-Masri, who was abducted from Macedonia and held in Afghanistan.17 El-Masri sued the CIA, and Angela Merkel asked then Secretary of State...34 Ex-detainee suit overshadows Rice- Merkel visit," Dec. 6, 2005. 19 Knowlton, Brian, " Merkel and Bush in ’spirited’ and friendly talks", The New

  4. ADVANCED MANUFACTURING TEAM

    NASA Image and Video Library

    2016-03-17

    JOHNNIE CLARK, BRIAN WEST, AND ZACK JONES OF MSFC’S ADVANCED MANUFACTURING TEAM, WITH MSFC’S XLINE SELECTIVE LASER MELTING SYSTEM. CURRENTLY ONE OF THE LARGEST METAL 3D PRINTERS, THE XLINE AT MARSHALL IS BEING USED TO DEVELOP AND CERTIFY NICKEL ALLOY 718 MATERIAL PROPERTIES AND LARGE MANUFACTURING TECH DEMOS FOR THE RS25 ENGINE AND THE COMMERCIAL CREWED VEHICLE PROJECTS.

  5. Ahmad Pesaran Honored with DOE Assistant Secretary's 2017 EERE Outstanding

    Science.gov Websites

    lithium-ion battery performance for electric vehicles. No stranger to inspiring colleagues, providing Michelbacher (INL, VTO Battery and Electrification), Steven Boyd (DOE, VTO Battery and Electrification), Brian Cunningham (DOE, VTO Battery and Electrification), Samuel Gillard (DOE, VTO Battery and Electrification

  6. Battle of Narratives

    DTIC Science & Technology

    2012-06-01

    18 De Nooy, Wouter, Andrej Mrvar , and Vladimir Batagelj , Exploratory Social Network Analysis with Pajek (New York: Cambridge University Press, 2005... Mrvar , and Vladimir Batagelj . Exploratory Social Network Analysis with Pajek. New York: Cambridge University Press, 2005. Democratic National...Review 54(1):33-48; Brian Uzzi. 1996 . "The Sources and Consequences of Embeddedness for the Economic Performance of Organizations: The Network Effect

  7. Authorship Correction: Sampling Key Populations for HIV Surveillance: Results From Eight Cross-Sectional Studies Using Respondent-Driven Sampling and Venue-Based Snowball Sampling.

    PubMed

    Rao, Amrita; Stahlman, Shauna; Hargreaves, James; Weir, Sharon; Edwards, Jessie; Rice, Brian; Kochelani, Duncan; Mavimbela, Mpumelelo; Baral, Stefan

    2018-01-15

    [This corrects the article DOI: 10.2196/publichealth.8116.]. ©Amrita Rao, Shauna Stahlman, James Hargreaves, Sharon Weir, Jessie Edwards, Brian Rice, Duncan Kochelani, Mpumelelo Mavimbela, Stefan Baral. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 15.01.2018.

  8. 76 FR 76707 - Brian Hamilton; El Paso Natural Gas and El Paso Western Pipelines; Notice of Complaint

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-08

    ...; El Paso Natural Gas and El Paso Western Pipelines; Notice of Complaint Take notice that on December 2... Paso Natural Gas and El Paso Western Pipelines (Respondents) alleging that the Respondents failed to... a high pressure interstate natural gas pipeline. The Complainant certifies that copies of the...

  9. Can Higher Education Foster Economic Growth? A Conference Summary. Chicago Fed Letter. Number 236a

    ERIC Educational Resources Information Center

    Mattoon, Richard H.

    2007-01-01

    On October 30, 2006, the Federal Reserve Bank of Chicago and the Midwest Higher Education Compact held a conference on higher education and economic growth. Speakers included Michael Moskow, Richard Lester, Michael Luger, Sean Safford, Larry Isaak, Stefanie Lenway, Rod Shrader, Brian Fabes, Arthur Rothkopf, Randy Eberts, Gary Fethke, Victor…

  10. USING DNA MICROARRAYS TO CHARACTERIZE GENE EXPRESSION IN TESTES OF FERTILE AND INFERTILE HUMANS AND MICE

    EPA Science Inventory

    USING DNA MICROARRAYS TO CHARACTERIZE GENE EXPRESSION
    IN TESTES OF FERTILE AND INFERTILE HUMANS AND MICE

    John C. Rockett1, J. Christopher Luft1, J. Brian Garges1, M. Stacey Ricci2, Pasquale Patrizio2, Norman B. Hecht2 and David J. Dix1
    Reproductive Toxicology Divisio...

  11. Inhibitory effects of p-cresol and p-hydroxy anisole dimers on expression of the cyclooxygenase-2 gene and lipopolysaccharide-stimulated activation of nuclear factor-κB in RAW264.7 cells.

    PubMed

    Murakami, Yukio; Kawata, Akifumi; Ito, Shigeru; Katayama, Tadashi; Fujisawa, Seiichiro

    2014-01-01

    Phenolic compounds, particularly dihydroxybiphenyl-related compounds, possess efficient anti-oxidative and anti-inflammatory activity. We investigated the anti-inflammatory activity of 2,2'-dihydroxy-5,5'-dimethylbiphenol (p-cresol dimer), 2,2'-dihydroxy-5,5'-dimethoxybiphenol (pHA dimer), p-cresol, p-hydroxyanisole (pHA) and 2-t-butyl-4-hydroxyanisole (BHA). The cytotoxicity of the investigated compounds against RAW264.7 cells was determined using a cell counting kit (CCK-8). Their inhibitory effects on cyclooxygenase-2 (Cox2) mRNA expression stimulated by lipopolysaccharide (LPS) were determined using northern blot analysis, and their inhibition of LPS-stimulated nuclear factor-kappa B (Nf-κb) activation was evaluated using enzyme-linked immunosorbent assay-like microwell colorimetric transcription factor activity assay. The molecular orbital energy was calculated on the basis of density function theory BLYP/6-31G*. The cytotoxicity of the compounds declined in the order pHA dimer > p-cresol dimer > BHA > p-cresol > pHA. The inhibitory effect on Cox2 expression and Nf-κb activation was enhanced by p-cresol dimer and pHA dimer, particularly the former, suggesting potent anti-inflammatory activity, whereas p-cresol and pHA showed weak activity, and BHA no activity. Both p-cresol dimer and pHA dimer were highly electronegative, as determined by quantum chemical calculations. Dimerization of p-cresol and pHA enhances their anti-inflammatory activity. p-Cresol dimer and pHA dimer, particularly the former, are potent anti-inflammatory agents. Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  12. The Clinicopathological Factors Associated with Disease Progression in Luminal A Breast Cancer and Characteristics of Metastasis: A Retrospective Study from A Single Center in China.

    PubMed

    Ye, Jingming; Wang, Wenjun; Xin, Ling; Owen, Sioned; Xu, Ling; Duan, Xuening; Cheng, Yuanjia; Zhang, Hong; Zhang, Shuang; Li, Ting; Liu, Yinhua

    2017-08-01

    This study investigated the clinicopathological factors associated with outcomes in patients with Luminal A breast cancer. Retrospective analysis of the association of clinicopathological factors and breast cancer outcome in 421 patients with newly-diagnosed Luminal-A breast cancer that were enrolled from January 2008 to December 2014. Clinicopathological data were analyzed to validate the relationship with disease-free survival (DFS) and overall survival (OS). Kaplan-Meier curves and log-rank tests were used to analyze the value of clinicopathological factors (tumor size, node status and lymphovascular invasion), and subsequent Cox regression analysis revealed significant prognostic factors. With a median of 61 months follow-up, the 5-year DFS and 5-year OS rate were 98.3% and 99.3%. Cox multivariate regression analysis showed that clinical anatomic stage, tumor size, status of lymph nodes, lymphovascular invasion and systemic treatment are strong prognostic factors for clinical outcome in patients with Luminal-A breast cancer. Of all 413 patients with stage I-III breast cancer, 14 presented with metastasis (3.4%) during the follow up. Bone (6/14, 42.9%) was the most common site of metastasis followed by liver (5/14, 35.7%) and lung (4/14, 28.6%). The median survival time after metastasis was 20.4 months. Of all the sites of distant metastasis, liver metastasis was the only factor that affected survival time after metastasis (χ 2 =6.263, p=0.012). Patients with Luminal A breast cancer have excellent outcomes. Liver metastasis is an important factor compressing the survival time after distant metastasis presents. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  13. Index of Oral Histories Relating to Naval Research and Development

    DTIC Science & Technology

    1985-01-01

    Repositories: NWC, DTNSRDC, NHC Individuals mentioned: Amlie, Dr. Thomas S. LaBerge , Dr. Walter McLean, Dr. William B. Parsons, RADM William S. Smith...future of R&D in the Navy. Repositories: NWC, DTNSRDC, NHC Individuals mentioned: Bennett, Dr. Ira Hollingsworth, Dr. Guilford L. LaBerge , Dr. Walter...DTNSRDC, NHC Individuals mentioned: Hunter, Dr. Hugh LaBerge . Dr. Walter McLean, Dr. William B. Brode, Dr. Wallace C. Sage, Dr. Bruce Wilson, Dr. Haskell

  14. COX-1 vs. COX-2 as a determinant of basal tone in the internal anal sphincter

    PubMed Central

    de Godoy, Márcio A. F.; Rattan, Neeru; Rattan, Satish

    2009-01-01

    Prostanoids, produced endogenously via cyclooxygenases (COXs), have been implicated in the sustained contraction of different smooth muscles. The two major types of COXs are COX-1 and COX-2. The COX subtype involved in the basal state of the internal anal sphincter (IAS) smooth muscle tone is not known. To identify the COX subtype, we examined the effect of COX-1- and COX-2-selective inhibitors, SC-560 and rofecoxib, respectively, on basal tone in the rat IAS. We also determined the effect of selective deletion of COX-1 and COX-2 genes (COX-1−/− and COX-2−/− mice) on basal tone in murine IAS. Our data show that SC-560 causes significantly more efficacious and potent concentration-dependent decreases in IAS tone than rofecoxib. In support of these data, significantly higher levels of COX-1 than COX-2 mRNA were found in the IAS. In addition, higher levels of COX-1 mRNA and protein were expressed in rat IAS than rectal smooth muscle. In wild-type mice, IAS tone was decreased 41.4 ± 3.4% (mean ± SE) by SC-560 (1 × 10−5 M) and 5.4 ± 2.2% by rofecoxib (P < 0.05, n = 5). Basal tone was 0.172 ± 0.021 mN//mg in the IAS from wild-type mice and significantly less (0.080 ± 0.015 mN/mg) in the IAS from COX-1−/− mice (P < 0.05, n = 5). However, basal tone in COX-2−/− mice was not significantly different from that in wild-type mice. We conclude that COX-1-related products contribute significantly to IAS tone. PMID:19056763

  15. COX-1 vs. COX-2 as a determinant of basal tone in the internal anal sphincter.

    PubMed

    de Godoy, Márcio A F; Rattan, Neeru; Rattan, Satish

    2009-02-01

    Prostanoids, produced endogenously via cyclooxygenases (COXs), have been implicated in the sustained contraction of different smooth muscles. The two major types of COXs are COX-1 and COX-2. The COX subtype involved in the basal state of the internal anal sphincter (IAS) smooth muscle tone is not known. To identify the COX subtype, we examined the effect of COX-1- and COX-2-selective inhibitors, SC-560 and rofecoxib, respectively, on basal tone in the rat IAS. We also determined the effect of selective deletion of COX-1 and COX-2 genes (COX-1(-/-) and COX-2(-/-) mice) on basal tone in murine IAS. Our data show that SC-560 causes significantly more efficacious and potent concentration-dependent decreases in IAS tone than rofecoxib. In support of these data, significantly higher levels of COX-1 than COX-2 mRNA were found in the IAS. In addition, higher levels of COX-1 mRNA and protein were expressed in rat IAS than rectal smooth muscle. In wild-type mice, IAS tone was decreased 41.4 +/- 3.4% (mean +/- SE) by SC-560 (1 x 10(-5) M) and 5.4 +/- 2.2% by rofecoxib (P < 0.05, n = 5). Basal tone was 0.172 +/- 0.021 mN//mg in the IAS from wild-type mice and significantly less (0.080 +/- 0.015 mN/mg) in the IAS from COX-1(-/-) mice (P < 0.05, n = 5). However, basal tone in COX-2(-/-) mice was not significantly different from that in wild-type mice. We conclude that COX-1-related products contribute significantly to IAS tone.

  16. Estimating outcomes and cost effectiveness using a single-arm clinical trial: ofatumumab for double-refractory chronic lymphocytic leukemia.

    PubMed

    Hatswell, Anthony J; Thompson, Gwilym J; Maroudas, Penny A; Sofrygin, Oleg; Delea, Thomas E

    2017-01-01

    Ofatumumab (Arzerra ® , Novartis) is a treatment for chronic lymphocytic leukemia refractory to fludarabine and alemtuzumab [double refractory (DR-CLL)]. Ofatumumab was licensed on the basis of an uncontrolled Phase II study, Hx-CD20-406, in which patients receiving ofatumumab survived for a median of 13.9 months. However, the lack of an internal control arm presents an obstacle for the estimation of comparative effectiveness. The objective of the study was to present a method to estimate the cost effectiveness of ofatumumab in the treatment of DR-CLL. As no suitable historical control was available for modelling, the outcomes from non-responders to ofatumumab were used to model the effect of best supportive care (BSC). This was done via a Cox regression to control for differences in baseline characteristics between groups. This analysis was included in a partitioned survival model built in Microsoft ® Excel with utilities and costs taken from published sources, with costs and quality-adjusted life years (QALYs) were discounted at a rate of 3.5% per annum. Using the outcomes seen in non-responders, ofatumumab is expected to add approximately 0.62 life years (1.50 vs. 0.88). Using published utility values this translates to an additional 0.30 QALYs (0.77 vs. 0.47). At the list price, ofatumumab had a cost per QALY of £130,563, and a cost per life year of £63,542. The model was sensitive to changes in assumptions regarding overall survival estimates and utility values. This study demonstrates the potential of using data for non-responders to model outcomes for BSC in cost-effectiveness evaluations based on single-arm trials. Further research is needed on the estimation of comparative effectiveness using uncontrolled clinical studies.

  17. Evaluation of preventive and therapeutic activity of novel non-steroidal anti-inflammatory drug, CG100649, in colon cancer: Increased expression of TNF-related apoptosis-inducing ligand receptors enhance the apoptotic response to combination treatment with TRAIL.

    PubMed

    Woo, Jong Kyu; Kang, Ju-Hee; Jang, Yeong-Su; Ro, Seonggu; Cho, Joong Myung; Kim, Hwan-Mook; Lee, Sang-Jin; Oh, Seung Hyun

    2015-04-01

    Non-steroidal anti-inflammatory drugs (NSAIDs) have been suggested as the potential new class of preventive or therapeutic antitumor agents. The aim of the present study was to evaluate the antitumor activity of the novel NSAID, CG100649. CG100649 is a novel NSAID dual inhibitor for COX-2 and carbonic anhydrase (CA)-I/-II. In the present study, we investigated the alternative mechanism by which CG100649 mediated suppression of the colon cancer growth and development. The anchorage‑dependent and -independent clonogenic assay showed that CG100649 inhibited the clonogenicity of human colon cancer cells. The flow cytometric analysis showed that CG100649 induced the G2/M cell cycle arrest in colon cancer cells. Animal studies showed that CG100649 inhibited the tumor growth in colon cancer xenograft in nude mice. Furthermore, quantitative PCR and FACS analysis demonstrated that CG100649 upregulated the expression of TNF-related apoptosis-inducing ligand (TRAIL) receptors (DR4 and DR5) but decreased the expression of decoy receptors (DcR1 and DcR2) in colon cancer cells. The results showed that CG100649 treatment sensitized TRAIL‑mediated growth suppression and apoptotic cell death. The combination treatment resulted in significant repression of the intestinal polyp formation in APCmin/+ mice. Our data clearly demonstrated that CG100649 contains preventive and therapeutic activity for colon cancer. The present study may be useful for identification of the potential benefit of the NSAID CG100649, for the achievement of a better treatment response in colon cancer.

  18. Potency and selectivity of carprofen enantiomers for inhibition of bovine cyclooxygenase in whole blood assays.

    PubMed

    Brentnall, Claire; Cheng, Zhangrui; McKellar, Quintin A; Lees, Peter

    2012-12-01

    Whole blood in vitro assays were used to determine the potency and selectivity of carprofen enantiomers for inhibition of the isoforms of cyclooxygenase (COX), COX-1 and COX-2, in the calf. S(+)-carprofen possessed preferential activity for COX-2 inhibition but, because the slopes of inhibition curves differed, the COX-1:COX-2 inhibition ratio decreased from 9.04:1 for inhibitory concentration (IC)10 to 1.84:1 for IC95. R(-) carprofen inhibited COX-2 preferentially only for low inhibition of the COX isoforms (IC10 COX-1:COX-2=6.63:1), whereas inhibition was preferential for COX-1 for a high level of inhibition (IC95 COX-1:COX-2=0.20:1). S(+) carprofen was the more potent inhibitor of COX isoforms; potency ratios S(+):R(-) carprofen were 11.6:1 for IC10 and 218:1 for IC90. Based on serum concentrations of carprofen enantiomers obtained after administration of a therapeutic dose of 1.4 mg/kg to calves subcutaneously, S(+)-carprofen concentrations exceeded the in vitro IC80 COX-2 value for 32 h and the IC20 for COX-1 for 33 h. The findings are discussed in relation to efficacy and safety of carprofen in calves. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. Technial Programme Committee

    NASA Astrophysics Data System (ADS)

    2014-06-01

    Chairpersons Dr Dinesh Sathyamoorthy, Science & Technology Research Institute for Defence (STRIDE), Ministry of Defence, Malaysia Associate Professor Sr Dr Abdul Rashid Mohamed Shariff, Universiti Putra Malaysia (UPM), Malaysia Dr Ahmad Fikri Abdullah, Universiti Putra Malaysia (UPM), Malaysia Dr Farrah Melissa Muharram, Universiti Putra Malaysia (UPM), Malaysia Members Professor Dr Li Jing, Beijing Normal University, China Professor Dr Iyyanki Muralikrishna, Administrative Staff College of India (ASCI), India Professor Dr Alias Abdul Rahman, Universiti Teknologi Malaysia (UTM), Malaysia Professor Dr Ismat Mohamed El Hassan, King Saud University, Saudi Arabia Professor Dr George Miliaresis, Open University of Cyprus, Cyprus Professor Dr Christine Pohl, Universiti Teknologi Malaysia (UTM), Malaysia Professor Dr Mahender Kotha, Goa University, India Associate Professor Dr Paolo Gamba, University of Pavia, Italy Associate Professor Dr Behara Seshadri Daya Sagar, Indian Statistical Institute (ISI), India Associate Professor Sr Ranjit Singh, Infrastructure University Kuala Lumpur (IUKL), Malaysia Associate Professor Dr Abdul Nasir Matori, Universiti Teknologi Petronas (UTP), Malaysia Associate Dr Lucian Dragut, West University of Timişoara, Romania Associate Professor Dr Saied Pirasteh, Islamic Azad University, Iran Associate Professor Dr Peter Yuen, Cranfield University, United Kingdom Associate Professor Dr Lim Hwee San, Universiti Sains Malaysia (USM), Malaysia Associate Professor Dr Wayan Suparta, Universiti Kebangsaan Malaysia (UKM), Malaysia Associate Professor Dr Tuong Thuy Vu, The University of Nottingham Malaysia Campus, Malaysia Associate Professor Dr Maged Mahmoud Marghany, Universiti Teknologi Malaysia (UTM), Malaysia Associate Professor Dr Rami Al-Ruzouq, University of Sharjah, UAE Associate Professor Dr Biswajeet Pradhan, Universiti Putra Malaysia (UPM), Malaysia Associate Professor Dr Helmi Zulhaidi Mohd Shafri, Universiti Putra Malaysia (UPM), Malaysia Associate Professor Dr Benny Peter, Universiti Teknologi Malaysia (UTM), Malaysia Associate Professor Dr Norzailawati Mohd Nor, International Islamic University Malaysia (IIUM), Malaysia Dr Josée Lévesque, Defence Research and Development Canada (DRDC), Canada Dr Ali Ariapour, Islamic Azad University, Iran Dr Zulkiflee Abd Latif, Universiti Teknologi MARA (UiTM), Malaysia Dr Lim Tien Sze, Multimedia University (MMU), Malaysia Dr Ruzinoor Che Mat, Universiti Utara Malaysia (UUM), Malaysia Dr Eran Sadek Said Md Sadek, Universiti Teknologi MARA (UiTM), Malaysia Dr Siti Khairunniza Bejo, Universiti Putra Malaysia (UPM) Dr Ramin Nourqolipour, National Organization of Forest, Range and Watershed Manage Sr Mohktar Azizi Mohd Din, Universiti Malaya Col (Rt) Frederic Hernoust, Magelli Marzieh Mokarram, University of Isf Mohd Fadhil Abuhan, Royal Malaysian Police, Malaysia

  20. Fractals and self-organized criticality in anti-inflammatory drugs

    NASA Astrophysics Data System (ADS)

    Phillips, J. C.

    2014-12-01

    Nonsteroidal anti-inflammatory drugs (NSAIDs) act through inhibiting prostaglandin synthesis, a catalytic activity possessed by two distinct cyclooxygenase (COX-1 and COX-2) isozymes encoded by separate genes. The discovery of COX-2 launched a new era in NSAID pharmacology, resulting in the synthesis, marketing, and widespread use of COX-2 selective inhibitors. Extensive structural studies of the biology of prostaglandin synthesis and inhibition have explained some of the differences between COX-1 and COX-2 functionality, but others are still unexplained. Notably these include molecular differences that cause COX-1 inhibitors to produce a slight decrease, and COX-2 inhibitors to induce a significant increase, in heart attacks and strokes. These differences were unexpected because of the 60% overall COX-1 and COX-2 sequence similarity and the 1-2 conservation of catalytic sites. Hydropathic analysis shows important bicyclic differences between COX-1 and COX-2 on a large scale outside the catalytic pocket. These differences involve much stronger amphiphilic interactions in COX-2 than in COX-1, and may explain the selective antiplatelet effectiveness of COX-2. Success of the non-Euclidean structural analysis is the result of using the new Brazilian hydropathicity scale based on self-organized criticality (SOC) of universal protein modules.

  1. Constitutively expressed COX-2 in osteoblasts positively regulates Akt signal transduction via suppression of PTEN activity.

    PubMed

    Li, Ching-Ju; Chang, Je-Ken; Wang, Gwo-Jaw; Ho, Mei-Ling

    2011-02-01

    Cyclooxygenase-2 (COX-2) is thought to be an inducible enzyme, but increasing reports indicate that COX-2 is constitutively expressed in several organs. The status of COX-2 expression in bone and its physiological role remains undefined. Non-selective non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, which commonly suppress COX-2 activity, were reported to suppress osteoblast proliferation via Akt/FOXO3a/p27(Kip1) signaling, suggesting that COX-2 may be the key factor of the suppressive effects of NSAIDs on proliferation. Although Akt activation correlates with PTEN deficiency and cell viability, the role of COX-2 on PTEN/Akt regulation remains unclear. In this study, we hypothesized that COX-2 may be constitutively expressed in osteoblasts and regulate PTEN/Akt-related proliferation. We examined the localization and co-expression of COX-2 and p-Akt in normal mouse femurs and in cultured mouse (mOBs) and human osteoblasts (hOBs). Our results showed that osteoblasts adjacent to the trabeculae, periosteum and endosteum in mouse femurs constitutively expressed COX-2, while COX-2 co-expressed with p-Akt in osteoblasts sitting adjacent to trabeculae in vivo, and in mOBs and hOBs in vitro. We further used COX-2 siRNA to test the role of COX-2 in Akt signaling in hOBs; COX-2 silencing significantly inhibited PTEN phosphorylation, enhanced PTEN activity, and suppressed p-Akt level and proliferation. However, replenishment of the COX-2 enzymatic product, PGE2, failed to reverse COX-2-dependent Akt phosphorylation. Furthermore, transfection with recombinant human COX-2 (rhCOX-2) significantly reversed COX-2 siRNA-suppressed PTEN phosphorylation, but this effect was reduced when the enzymatic activity of rhCOX-2 was blocked. This finding indicated that the effect of COX-2 on PTEN/Akt signaling is not related to PGE2 but still dependent on COX-2 enzymatic activity. Conversely, COX-1 silencing did not affect PTEN/Akt signaling. Our findings provide new insight into bone physiology; namely, that COX-2 is constitutively expressed in osteoblasts in the dynamic bone growth area, which facilitates osteoblast proliferation via PTEN/Akt/p27(Kip1) signaling. Copyright © 2010 Elsevier Inc. All rights reserved.

  2. The U.S. Army Study of the Human Dimension in the Future 2015-2024

    DTIC Science & Technology

    2008-04-01

    136 6-3. Burnout ...They’d extolled the virtues of the course telling the students “Best leadership laboratory in the world!” Brian would find out first hand soon enough...in information age societies. Global demand for international higher education will increase from 1.8 million international students in 2000 to 7.2

  3. Advances in Flexible Hybrid Electronics Reliability

    DTIC Science & Technology

    2017-03-01

    Advances in Flexible Hybrid Electronics Reliability Douglas R. Hackler, Richard L. Chaney, Brian N. Meek, Darrell E. Leber, Seth D. Leija, Kelly J...www.americansemi.com Abstract: Flexible Hybrid Electronics combine the best characteristics of printed electronics and silicon ICs to create high performance...presented for flexible hybrid electronics systems. Keywords: FleX; flexible; flexible hybrid electronics ; FHE; Silicon-on-Polymer Introduction

  4. Condition of Access: Higher Education for Lower Income Students. ACE/Praeger Series on Higher Education.

    ERIC Educational Resources Information Center

    Heller, Donald E., Ed.

    Chapters in this collection discuss the state of access to U.S. higher education institutions for lower income students and the status of student aid programs. The chapters of part 1, "College Access Issues for Lower Income Students," contains: (1) "Educational Opportunity in America" (Brian K. Fitzgerald and Jennifer A. Delaney); and (2) "An…

  5. Foreign Language Analysis and Recognition (FLARe) Initial Progress

    DTIC Science & Technology

    2012-11-29

    University Language Modeling ToolKit CoMMA Count Mediated Morphological Analysis CRUD Create, Read , Update & Delete CPAN Comprehensive Perl Archive...DATES COVERED (From - To) 1 October 2010 – 30 September 2012 4. TITLE AND SUBTITLE Foreign Language Analysis and Recognition (FLARe) Initial Progress...AFRL-RH-WP-TR-2012-0165 FOREIGN LANGUAGE ANALYSIS AND RECOGNITION (FLARE) INITIAL PROGRESS Brian M. Ore

  6. Reflections on the "Site of Struggle": Girls' Experience of Secondary Education in the Late 1950s

    ERIC Educational Resources Information Center

    Spencer, Stephanie

    2004-01-01

    Brian Simon used the phrase 'site of struggle' to describe the class-based inequalities that were played out in the provisions for English compulsory education. In the nineteenth century, the growth of the state system for the working class alongside the predominantly middle-class independent sector simply confirmed existing class hierarchies with…

  7. One Web Satellites Ground Breaking

    NASA Image and Video Library

    2017-03-16

    Kelvin Manning, associate director of NASA's Kennedy Space Center, talks with Brian Holz, CEO of OneWeb Satellites, following the groundbreaking ceremony at Kennedy's Exploration Park for OneWeb. The company, in partnership with Airbus, is building a 150,000-square-foot factory to manufacture satellites that will connect all areas of the world to the Internet wirelessly. Photo credit: NASA/Kim Shiflett

  8. Improving Security in Software Acquisition and Runtime Integration With Data Retention Specifications

    DTIC Science & Technology

    2016-04-30

    Data Retention Specifications Daniel Smullen, Research Assistant, Carnegie Mellon University Travis Breaux, Assistant Professor, Carnegie Mellon... Carnegie Mellon University Travis Breaux, Assistant Professor, Carnegie Mellon University Cybersecurity Figure of Merit CAPT Brian Erickson, USN, SPAWAR...Integration With Data Retention Specifications Daniel Smullen—is a Research Assistant enrolled in the software engineering PhD program at Carnegie Mellon

  9. Friction Stir Welding of Thick Section Aluminum for Military Vehicle Applications

    DTIC Science & Technology

    2012-12-01

    Friction Stir Welding of Thick Section Aluminum for Military Vehicle Applications by Brian Thompson, Kevin Doherty, Craig Niese, Mike Eff...International Symposium on Friction Stir Welding (9ISFSW), Huntsville, AL, 15–17 May 2012. Approved for public release...Aberdeen Proving Ground, MD 21005-5069 ARL-RP-417 December 2012 Friction Stir Welding of Thick Section Aluminum for Military

  10. Proceedings of the Annual Conference on Manual Control (15th) held March 20 - 22, 1979, Wright State University, Dayton, Ohio

    DTIC Science & Technology

    1979-11-01

    Performance in a Precognitive Tracking Task," Proc. 13th Annual Conf. on Manual Control, pp. 152-165, June 1977. (32] Repa Brian S. and Robert S. Zucker...operators that have received attention in manual control. Precognitive manual control displays differ from the pursuit and compensatory displays of the

  11. Technology Transfer in the Navy Research and Development Community: An Analysis of Private Industry and Navy Laboratory Performance

    DTIC Science & Technology

    1990-09-01

    Managing Innovation in the Public Sector, Naval Postgraduate School, Mon- terey, California. -1975. "The Linker Role in the Technology Transfer Process", in...1984. n.p. Quinn, Brian. 1985. " Managing Innovation : Controlled Chaos." Harvard Business Review, May-June, pp. 62-68. Quinn, John. 1985. "How Companies

  12. The Adaptive Edge: Introducing Adaptive Skills Techniques to Army Special Forces

    DTIC Science & Technology

    2010-12-01

    Submitted in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE IN DEFENSE ANALYSIS from the NAVAL...Brian Greenshields Second Reader Gordon McCormick Chairman, Department of Defense Analysis iv THIS PAGE INTENTIONALLY LEFT BLANK v...Cultural Adaptability as: Taking action to learn about and understand the climate , orientation, needs, values of other groups, organizations, and

  13. Predictors of Organizational-Level Testability Attributes

    DTIC Science & Technology

    1987-05-01

    A. Elizabeth Gilreath Brian A. Kelley 13a. TYPE OF REPORT 13b. TIME COVERED 14. DATE OF REPORT (YearB, M RSnt, Day) 15.PAGECOUNT ’Final JFROM A TO 6... BRU count. These counts are "described in subsections 6,.2.1.1 and 6.2.1.2. and are further subdivided in Figure 6-4. 6.2.1.1 Functional Cross

  14. The Psychology of Delivering a Psychological Service: Self-Organised Learning as a Model for Consultation

    ERIC Educational Resources Information Center

    Clarke, Steve; Jenner, Simon

    2006-01-01

    The article describes how one Educational Psychology Service in the UK developed a service delivery based on self-organised learning (SOL). This model is linked to the paradigms and discourses within which educational psychology and special educational needs work. The work described here is dedicated to the memory of Brian Roberts, academic, close…

  15. DETAIL VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY. SEEN FROM EAST SIDE OF CIRCLE LOOKING NORTH AT 2395 PIEDMONT, SIGMA PI HOUSE BY FREDERICK H. REIMERS, 1928. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  16. Korean Unification: The Way Forward

    DTIC Science & Technology

    2009-03-01

    THE WAY FORWARD by Brian A. Forster March 2009 Thesis Advisor: Robert Weiner Second Reader: Christopher P .Twomey THIS PAGE ...INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information is...possibility of a unified Korean nation. 15. NUMBER OF PAGES 109 14. SUBJECT TERMS Korean Unification, The Republic of Korea, The Democratic People’s

  17. Co-Sponsorship of 1999 Conference on the Dynamics of Molecular Collision (17th) held in Lake Harmony, Pennslyvania on 18-23 July 1999.

    DTIC Science & Technology

    2000-02-25

    University of the Negev , BeerSheva 84105, Israel Abstract The fundamental symmetric CHj stretch (VCHX «nd the second (3*tM> and third (4VCH...the Institutes for Applied Research Ben-Gurion University of the Negev Beer-Sheva 84105, Israel Brian D. Bean Department of Chemistry Stanford

  18. Misplaced Modifier: Honors Students and Honors Education

    ERIC Educational Resources Information Center

    Etheridge, Brian C.

    2014-01-01

    The challenge posed by for-profit educators to the existing system is a real one that is not likely to go away any time soon and is, in fact, likely to intensify. Brian Etheridge describes Gary Bell's essay as a thoughtful exegesis on how we came to this point. He roots his narrative in the explosion of the profit motive, citing several instances…

  19. Merriwether Cherokee Potamology Study

    DTIC Science & Technology

    2017-05-01

    reference only and do not directly correlate to flow hydrographs created and utilized for this study . MRG&P Report No. 9 58 Figure 2-30...Mississippi Valley Division Engineer Research and Development Center Merriwether-Cherokee Potamology Study MRG&P Report No. 9 • May 2017...Mississippi River Geomorphology & Potamology (MRG&P) Program MRG&P Report No. 9 May 2017 Merriwether-Cherokee Potamology Study Brian M. Hall

  20. Brian K. Kobilka and G-protein-coupled Receptors (GPCR)

    Science.gov Websites

    the laboratory's Advanced Photon Source (APS) to make the first discovery of the structure of a human the structure of β2AR at the exact moment that the protein-receptor complex signals across the carrying out its biological mission. ... In order to obtain the structure of a GPCR, Kobilka and his

  1. Depth Optimization Study

    DOE Data Explorer

    Kawase, Mitsuhiro

    2009-11-22

    The zipped file contains a directory of data and routines used in the NNMREC turbine depth optimization study (Kawase et al., 2011), and calculation results thereof. For further info, please contact Mitsuhiro Kawase at kawase@uw.edu. Reference: Mitsuhiro Kawase, Patricia Beba, and Brian Fabien (2011), Finding an Optimal Placement Depth for a Tidal In-Stream Conversion Device in an Energetic, Baroclinic Tidal Channel, NNMREC Technical Report.

  2. NCI at Frederick Employees Receive Awards at the Spring Research Festival | Poster

    Cancer.gov

    NCI and Frederick National Laboratory staff members were among those honored at the Spring Research Festival Awards Ceremony on May 28. The ceremony was the culmination of the festival, which was sponsored by the National Interagency Confederation for Biological Research (NICBR), May 4–7. Maj. Gen. Brian Lein, commanding general, U.S. Army Medical Research and Materiel Command

  3. STS-57 Endeavour, Orbiter Vehicle (OV) 105, official crew portrait

    NASA Image and Video Library

    1993-07-01

    STS057-S-002 (February 1993) --- These seven astronauts are in training for NASA's mission scheduled for spring of this year. In front are astronauts Brian Duffy (left) and Ronald J. Grabe, pilot and commander, respectively. In back are (left to right) astronauts Peter J. Wisoff, Nancy J. Sherlock, Janice E. Voss, all mission specialists; and G. David Low, payload commander.

  4. Literacy as Value: Cultural Capital in Barbara Bush's Foundation for Family Literacy

    ERIC Educational Resources Information Center

    Westmoreland, Brandi Davis

    2010-01-01

    Many different views of literacy exist. In my study, I make use of Brian V. Street's two major models of literacy--the autonomous and the ideological. These models show contrasting views of literacy and are based on very different assumptions. I examine the views of literacy prevalent in family literacy campaigns, with special focus on Barbara…

  5. Committee for International Conference on Mechanical Engineering Research (ICMER 2011)

    NASA Astrophysics Data System (ADS)

    Yusoff, Ahmad Razlan Bin

    2012-09-01

    Scientific Advisory Committee: 1) Prof. Dr. Ahmad Kamal Ariffin (UKM) 2) Prof. Dr. Hj. Rosli Abu Bakar (UMP) 3) Prof. Dr. Hanafi Ismail (USM) 4) Prof. Ir. Dr. Mohd Jailani Mohd Nor (MoHE) 5) Prof. Dr. Zahari Taha (UMP) 6) Prof. Dr. Masjuki Haji Hassan 7) Prof. Ir. Dr. Ramesh Singh (UNITEN) 8) Prof. Dr. Razali Ayob (UTEM) 9) Prof. Dr. Wan Khairuddin (UTM) 10) Prof. Dr. Sulaiman Hj. Hasan (UTHM) 11) Prof. Dr. Zuraidah Mohd. Zain (UniMAP) 12) Prof. Dr. Horizon Gitano (USM) 13) Prof. Dr. K.V Sharma (UMP) 14) Prof. Dr. Shahrani Anuar (UMP) 15) Assoc. Prof. Dr. Abd Rashid Abd. Aziz (UTP) 16) Assoc. Prof. Dr. Aidy Ali (UPM) 17) Assoc. Prof. Dr. Saidur Rahman (UM) 18) Assoc. Prof. Dr. Md Abdul Maleque (UIA) Organizing Committee Chairman: Prof. Dr. Hj. Rosli Abu Bakar Co-Chair: Prof. Dr. Zahari Taha Co-Chair: Prof. Ir. Dr. Jailani Salihon Secretary: Dr. Rizalman Mamat Committee on Keynote Speaker 1) Kumaran Kadirgama (Chair) 2) Prof. Dr. K.V. Sharma 3) Haji Amirruddin Abdul Kadir 4) Miminorazeansuhaila Loman 5) Mohd Akramin Mohd Romlay Technical Committee (Peer Review & Proceedings) 1) Dr. Abdul Adam Abdullah (Chair) 2) Dr. Ahmad Razlan Yusoff 3) Mohd Yusof Taib 4) Dr. Md. Mustafizur Rahman 5) Dr. Hjh. Yusnita Rahayu 6) Dr. Gigih Priyandoko 7) Dr. Agung Sudrajad 8) Muhammad Hatifi Mansor 9) Mohd Fadzil Abdul Rahim Technical Committee (Panels & Session Chairs) 1) Dr. Mahadzir Ishak (Chair) 2) Prof. Dr. Shahrani Anuar 3) Dr. Maisara Mohyeldin Gasim Mohamed 4) Muhammad Ammar Nik Mu'tasim 5) Ahmad Basirul Subha bin Alias Technical Committee (Journal Publication) 1) Dr. Ahmad Razlan bin Yusoff (Chair) 2) Mohd Yusof Taib 3) Dr. Mahadzir Ishak 4) Dr. Abdul Adam Abdullah 5) Hj. Amirruddin Abdul Kadir 6) Hadi Abdul Salaam Bureau of Publicity & Website 1) Dr. Muhamad Arifpin Mansor (Chair) 2) Amir Abdul Razak 3) Idris Mat Sahat 4) Prof. Dr. Hj. Rosli Abu Bakar 5) Muhamad Zuhairi Sulaiman 6) Dr. Sugeng Ariyono 7) Asnul Hadi Ahmad 8) Mohd Tarmizy Che Kar 9) Mohd Padzly Radzi Bureau of Special Task & Poster 1) Lee Giok Chui (Chair) 2) Mohd Fadzil Abdul Rahim 3) Che Ku Eddy Nizwan 4) Hazami Che Hussain 5) Mohd Fazli Ismail 6) Mahdhir Mohd Yusof 7) Mohd Padzly Radzi 8) Rahimah Che Ramli Secretariats 1) Ir. Ahmad Rasdan Ismail (Chair) 2) Mohd Shahri Mohd Akhir 3) Luqman Hakim Ahmad Shah 4) Juliawati Alias 5) Nurazima Ismail 6) Mohamad Faizal Mohamed Zahri 7) Raja Allen Jordan Izzuddin Shah 8) Rosidah Mohd Norsat 9) Norshalawati Mat Yusof 10) Zainab Daud 11) Nur Sufiah Jamaludin 12) Azslinda Ibrahim 13) Nurul Azreen Zainal Abidin 14) Nurul Ashikin Mohd Khalil 15) Mohd Zaki Mohd Ali

  6. The influence of cyclooxygenase-1 expression on the efficacy of cyclooxygenase-2 inhibition in head and neck squamous cell carcinoma cell lines.

    PubMed

    Park, Seok-Woo; Kim, Hyo-Sun; Choi, Myung-Sun; Kim, Ji-Eun; Jeong, Woo-Jin; Heo, Dae-Seog; Sung, Myung-Whun

    2011-06-01

    We have previously observed that cyclooxygenase-2 (COX-2) inhibition blocked the production of vascular endothelial growth factor (VEGF) in some head and neck squamous cell carcinoma (HNSCC) cells. However, as some HNSCC cells showed little response to COX-2 inhibition, although they highly expressed COX-2 and prostaglandin E2, we set out to elucidate what made this difference between them and focused on the possibility of the differential expression of COX-1. In western blotting, we found that COX-1 was expressed in SNU-1041 and SNU-1066, but not in SNU-1076 and PCI-50. Only in those cell lines without expression of COX-1 was VEGF production blocked meaningfully by small interfering RNA of COX-2. However, by cotreating with small interfering RNAs of COX-2 and COX-1, VEGF synthesis and prostaglandin E2 were inhibited in SNU-1041 and SNU-1066, similarly in SNU-1076 and PCI-50 with high expression of only COX-2. We also found that there was no difference in the pattern of prostaglandin synthesis between COX-2 and COX-1 through enzyme-linked immunosorbent assay for various prostaglandins. Our study suggests that, as COX-1 and COX-2 express and affect VEGF synthesis in HNSCC cells, we should check COX-1 expression in investigations on cancer treatment by inhibiting COX-2-induced prostaglandins.

  7. The roles of the cyclo-oxygenases types one and two in prostaglandin synthesis in human fetal membranes at term.

    PubMed

    Sawdy, R J; Slater, D M; Dennes, W J; Sullivan, M H; Bennett, P R

    2000-01-01

    The aim of this study was to determine the relative contributions of cyclo-oxygenase (COX) types 1 and 2 to prostaglandin synthesis at term. Fetal membranes were collected from 6 pregnancies after elective caesarean section at term, prior to labour. The presence of COX-1 and COX-2 protein was determined using Western analysis. The relative contributions of the two isoforms of COX to prostaglandin synthesis were determined by incubation of fetal membrane discs with either a COX-2 selective inhibitor, SC236, or a COX-1 selective inhibitor, SC560, and measurement of prostaglandin release during 24 h using enzyme-linked immuno-sorbent assay (ELISA). Both COX-1 and COX-2 protein were demonstrated in amnion and chorion-decidua. The COX-2 selective inhibitor, SC-236, significantly reduced prostaglandin synthesis, both in its COX-2 specific and higher, non-specific concentration ranges. The COX-1 selective inhibitor, SC-560, had no effect upon prostaglandin synthesis in its COX-1 specific concentration range, but did significantly reduce prostaglandin synthesis at higher, non-selective concentrations. Fetal membranes contain both COX-1 and COX-2 at term, but only COX-2 contributes towards prostaglandin synthesis. COX-2 selective NSAI drugs will be as effective as non-selective agents in inhibition of fetal membrane prostaglandin synthesis and may represent a new strategy for tocolysis. Copyright 2000 Harcourt Publishers Ltd.

  8. Expression Analysis of Dopamine Receptor Subtypes in Normal Human Pituitaries, Nonfunctioning Pituitary Adenomas and Somatotropinomas, and the Association between Dopamine and Somatostatin Receptors with Clinical Response to Octreotide-LAR in Acromegaly

    PubMed Central

    Neto, Leonardo Vieira; Machado, Evelyn de O.; Luque, Raul M.; Taboada, Giselle F.; Marcondes, Jorge B.; Chimelli, Leila M. C.; Quintella, Leonardo Pereira; Niemeyer, Paulo; de Carvalho, Denise P.; Kineman, Rhonda D.; Gadelha, Mônica R.

    2009-01-01

    Context: Dopamine receptor (DR) and somatostatin receptor subtype expression in pituitary adenomas may predict the response to postsurgical therapies. Objectives: Our objectives were to assess and compare the mRNA levels of DR1-5 and somatostatin receptors 1–5 in normal pituitaries (NPs), nonfunctioning pituitary adenomas (NFPAs), and somatotropinomas. In addition, we determined whether the level of DR expression correlates with the in vivo response to octreotide-LAR in acromegalic patients. Design and Patients: Eight NPs, 30 NFPAs, and 39 somatotropinomas were analyzed for receptor mRNA levels by real-time RT-PCR. The DR2 short variant was estimated as the DR2 long/DR2 total (DR2T). The relationship between DR expression and the postsurgical response to octreotide-LAR was assessed in 19 of the acromegalic patients. Results: DR3 was not detected. The relationship between expression levels of DR subtypes in NPs and somatotropinomas was DR2T⋙DR4≫DR5>DR1, whereas in NFPAs, DR2T⋙DR4≫DR1>DR5. The DR2 short variant was the predominant DR2 variant in the majority of samples. In acromegalics treated with octreotide-LAR, DR1 was negatively correlated with percent GH reduction (3 months: r = −0.67, P = 0.002; and 6 months: r = −0.58, P = 0.009), and DR5 was positively correlated with percent IGF-I reduction (3 months: r = 0.55, P = 0.01; and 6 months: r = 0.47, P = 0.04). Conclusions: DR2 is the predominant DR subtype in NPs, NFPAs, and somatotropinomas. The fact that DR1, DR4, and DR5 are also expressed in many adenomas tested suggests that these receptors might also play a role in the therapeutic impact of postsurgical medical therapies in patients with NFPA and acromegaly. This was supported by the finding that the in vivo response to octreotide-LAR was negatively associated with DR1 and positively associated with DR5. PMID:19293270

  9. Cell-type-specific roles for COX-2 in UVB-induced skin cancer

    PubMed Central

    Herschman, Harvey

    2014-01-01

    In human tumors, and in mouse models, cyclooxygenase-2 (COX-2) levels are frequently correlated with tumor development/burden. In addition to intrinsic tumor cell expression, COX-2 is often present in fibroblasts, myofibroblasts and endothelial cells of the tumor microenvironment, and in infiltrating immune cells. Intrinsic cancer cell COX-2 expression is postulated as only one of many sources for prostanoids required for tumor promotion/progression. Although both COX-2 inhibition and global Cox-2 gene deletion ameliorate ultraviolet B (UVB)-induced SKH-1 mouse skin tumorigenesis, neither manipulation can elucidate the cell type(s) in which COX-2 expression is required for tumorigenesis; both eliminate COX-2 activity in all cells. To address this question, we created Cox-2 flox/flox mice, in which the Cox-2 gene can be eliminated in a cell-type-specific fashion by targeted Cre recombinase expression. Cox-2 deletion in skin epithelial cells of SKH-1 Cox-2 flox/flox;K14Cre + mice resulted, following UVB irradiation, in reduced skin hyperplasia and increased apoptosis. Targeted epithelial cell Cox-2 deletion also resulted in reduced tumor incidence, frequency, size and proliferation rate, altered tumor cell differentiation and reduced tumor vascularization. Moreover, Cox-2 flox/flox;K14Cre + papillomas did not progress to squamous cell carcinomas. In contrast, Cox-2 deletion in SKH-1 Cox-2 flox/flox; LysMCre + myeloid cells had no effect on UVB tumor induction. We conclude that (i) intrinsic epithelial COX-2 activity plays a major role in UVB-induced skin cancer, (ii) macrophage/myeloid COX-2 plays no role in UVB-induced skin cancer and (iii) either there may be another COX-2-dependent prostanoid source(s) that drives UVB skin tumor induction or there may exist a COX-2-independent pathway(s) to UVB-induced skin cancer. PMID:24469308

  10. Cell-type-specific roles for COX-2 in UVB-induced skin cancer.

    PubMed

    Jiao, Jing; Mikulec, Carol; Ishikawa, Tomo-o; Magyar, Clara; Dumlao, Darren S; Dennis, Edward A; Fischer, Susan M; Herschman, Harvey

    2014-06-01

    In human tumors, and in mouse models, cyclooxygenase-2 (COX-2) levels are frequently correlated with tumor development/burden. In addition to intrinsic tumor cell expression, COX-2 is often present in fibroblasts, myofibroblasts and endothelial cells of the tumor microenvironment, and in infiltrating immune cells. Intrinsic cancer cell COX-2 expression is postulated as only one of many sources for prostanoids required for tumor promotion/progression. Although both COX-2 inhibition and global Cox-2 gene deletion ameliorate ultraviolet B (UVB)-induced SKH-1 mouse skin tumorigenesis, neither manipulation can elucidate the cell type(s) in which COX-2 expression is required for tumorigenesis; both eliminate COX-2 activity in all cells. To address this question, we created Cox-2(flox/flox) mice, in which the Cox-2 gene can be eliminated in a cell-type-specific fashion by targeted Cre recombinase expression. Cox-2 deletion in skin epithelial cells of SKH-1 Cox-2(flox/flox);K14Cre(+) mice resulted, following UVB irradiation, in reduced skin hyperplasia and increased apoptosis. Targeted epithelial cell Cox-2 deletion also resulted in reduced tumor incidence, frequency, size and proliferation rate, altered tumor cell differentiation and reduced tumor vascularization. Moreover, Cox-2(flox/flox);K14Cre(+) papillomas did not progress to squamous cell carcinomas. In contrast, Cox-2 deletion in SKH-1 Cox-2(flox/flox); LysMCre(+) myeloid cells had no effect on UVB tumor induction. We conclude that (i) intrinsic epithelial COX-2 activity plays a major role in UVB-induced skin cancer, (ii) macrophage/myeloid COX-2 plays no role in UVB-induced skin cancer and (iii) either there may be another COX-2-dependent prostanoid source(s) that drives UVB skin tumor induction or there may exist a COX-2-independent pathway(s) to UVB-induced skin cancer. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  11. Differential cyclooxygenase-2 expression in squamous cell carcinoma and adenocarcinoma of the uterine cervix.

    PubMed

    Kim, Yong Bae; Kim, Gwi Eon; Pyo, Hong Ryull; Cho, Nam Hoon; Keum, Ki Chang; Lee, Chang Geol; Seong, Jinsil; Suh, Chang Ok; Park, Tchan Kyu

    2004-11-01

    To determine the differential expression of cyclooxygenase-2 (COX-2) in patients with squamous cell carcinoma (SCC) and adenocarcinoma (ADC) of the uterine cervix and the prognostic significance of COX-2 expression in these histologic types. A total of 105 International Federation of Gynecology and Obstetrics Stage IIB uterine cervical cancer patients were screened for COX-2 expression immunohistochemically. COX-2 expression was determined in invasive cervical SCC (n = 84) and invasive cervical ADC (n = 21). To determine the clinical significance of COX-2 expression by histologic type, the patients were arbitrarily divided into four groups: SCC/COX-2 negative (n = 64); SCC/COX-2 positive (n = 20); ADC/COX-2 negative (n = 9); and ADC/COX-2 positive (n = 12). The clinical response to treatment, patterns of treatment failure, and survival data by COX-2 expression were compared for these two major histologic types. Univariate and multivariate analyses were performed to identify the prognostic factors influencing survival. Immunohistochemical examination showed that COX-2 expression was more frequently observed in ADC than in SCC (57% vs. 24%, p = 0.007). Moreover, COX-2 expression was an important predictor of treatment response, irrespective of the histologic type. All COX-2-negative patients achieved complete remission after initial treatment; 17% of SCC patients and 33% of ADC patients with COX-2 expression did not have complete remission after the initial treatment. The incidence of local failure for those with COX-2 expression was significantly greater than for COX-2-negative patients, regardless of histologic type. With a minimal follow-up of 60 months, the overall 5-year actuarial survival rate for SCC and ADC patients was 79% and 62%, respectively (p = 0.05). The 5-year disease-free survival rate for SCC and ADC patients was 73% and 56%, respectively (p = 0.13). Irrespective of the pathologic type, COX-2-positive patients had an unfavorable prognosis. The overall 5-year actuarial survival rate was 57% for COX-2-positive patients and 83% for COX-2-negative patients (p = 0.001). When patients were stratified into the four groups according to histologic type and COX-2 expression status, ADC/COX-2-positive patients had the worst prognosis, with an overall 5-year actuarial survival rate of 49% compared with 78% for ADC/COX-2-negative patients, 62% for SCC/COX-2-positive, and 84% for SCC/COX-2-negative patients (p = 0.007, log-rank test). Irrespective of histologic type, COX-2 expression was an independent prognostic factor by univariate and multivariate analyses. In uterine cervical cancer, COX-2 was expressed in a greater proportion of ADC patients than SCC patients. COX-2 expression was also identified as a major determiner of a poor response to treatment and of an unfavorable prognosis, irrespective of the histologic type, reflecting the importance of the COX-2 protein in the acquisition of biologic aggressiveness and more malignant phenotype or increased resistance to the standard chemotherapy and radiotherapy in both histologic types. Given these observations, we believe that that ADC/COX-2-positive patients might be appropriate candidates for future trials of selective COX-2 inhibitor adjunctive therapy.

  12. Platelet cyclooxygenase expression in normal dogs.

    PubMed

    Thomason, J; Lunsford, K; Mullins, K; Stokes, J; Pinchuk, L; Wills, R; McLaughlin, R; Langston, C; Pruett, S; Mackin, A

    2011-01-01

    Human platelets express both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Variation in COX-2 expression could be a mechanism for variable response to aspirin. The hypotheses were that circulating canine platelets express COX-1 and COX-2, and that aspirin alters COX expression. The objective was to identify changes in platelet COX expression and in platelet function caused by aspirin administration to dogs. Eight female, intact hounds. A single population, repeated measures design was used to evaluate platelet COX-1 and COX-2 expression by flow cytometry before and after aspirin (10 mg/kg Q12h for 10 days). Platelet function was analyzed via PFA-100(®) (collagen/epinephrine), and urine 11-dehydro-thromboxane B(2) (11-dTXB(2)) was measured and normalized to urinary creatinine. Differences in COX expression, PFA-100(®) closure times, and urine 11-dTXB(2 ): creatinine ratio were analyzed before and after aspirin administration. Both COX-1 and COX-2 were expressed in canine platelets. COX-1 mean fluorescent intensity (MFI) increased in all dogs, by 250% (range 63-476%), while COX-2 expression did not change significantly (P = 0.124) after aspirin exposure, with large interindividual variation. PFA-100(®) closure times were prolonged and urine 11-dTXB(2) concentration decreased in all dogs after aspirin administration. Canine platelets express both COX isoforms. After aspirin exposure, COX-1 expression increased despite impairment of platelet function, while COX-2 expression varied markedly among dogs. Variability in platelet COX-2 expression should be explored as a potential mechanism for, or marker of, variable aspirin responsiveness. Copyright © 2011 by the American College of Veterinary Internal Medicine.

  13. Role of cyclooxygenase isoforms in the altered excitatory motor pathways of human colon with diverticular disease.

    PubMed

    Fornai, M; Colucci, R; Antonioli, L; Ippolito, C; Segnani, C; Buccianti, P; Marioni, A; Chiarugi, M; Villanacci, V; Bassotti, G; Blandizzi, C; Bernardini, N

    2014-08-01

    The COX isoforms (COX-1, COX-2) regulate human gut motility, although their role under pathological conditions remains unclear. This study examines the effects of COX inhibitors on excitatory motility in colonic tissue from patients with diverticular disease (DD). Longitudinal muscle preparations, from patients with DD or uncomplicated cancer (controls), were set up in organ baths and connected to isotonic transducers. Indomethacin (COX-1/COX-2 inhibitor), SC-560 (COX-1 inhibitor) or DFU (COX-2 inhibitor) were assayed on electrically evoked, neurogenic, cholinergic and tachykininergic contractions, or carbachol- and substance P (SP)-induced myogenic contractions. Distribution and expression of COX isoforms in the neuromuscular compartment were assessed by RT-PCR, Western blot and immunohistochemical analysis. In control preparations, neurogenic cholinergic contractions were enhanced by COX inhibitors, whereas tachykininergic responses were blunted. Carbachol-evoked contractions were increased by indomethacin or SC-560, but not DFU, whereas all inhibitors reduced SP-induced motor responses. In preparations from DD patients, COX inhibitors did not affect electrically evoked cholinergic contractions. Both indomethacin and DFU, but not SC-560, decreased tachykininergic responses. COX inhibitors did not modify carbachol-evoked motor responses, whereas they counteracted SP-induced contractions. COX-1 expression was decreased in myenteric neurons, whereas COX-2 was enhanced in glial cells and smooth muscle. In control colon, COX-1 and COX-2 down-regulate cholinergic motility, whereas both isoforms enhance tachykininergic motor activity. In the presence of DD, there is a loss of modulation by both COX isoforms on the cholinergic system, whereas COX-2 displays an enhanced facilitatory control on tachykininergic contractile activity. © 2014 The British Pharmacological Society.

  14. Role of cyclooxygenase isoforms in the altered excitatory motor pathways of human colon with diverticular disease

    PubMed Central

    Fornai, M; Colucci, R; Antonioli, L; Ippolito, C; Segnani, C; Buccianti, P; Marioni, A; Chiarugi, M; Villanacci, V; Bassotti, G; Blandizzi, C; Bernardini, N

    2014-01-01

    BACKGROUND AND PURPOSE The COX isoforms (COX-1, COX-2) regulate human gut motility, although their role under pathological conditions remains unclear. This study examines the effects of COX inhibitors on excitatory motility in colonic tissue from patients with diverticular disease (DD). EXPERIMENTAL APPROACH Longitudinal muscle preparations, from patients with DD or uncomplicated cancer (controls), were set up in organ baths and connected to isotonic transducers. Indomethacin (COX-1/COX-2 inhibitor), SC-560 (COX-1 inhibitor) or DFU (COX-2 inhibitor) were assayed on electrically evoked, neurogenic, cholinergic and tachykininergic contractions, or carbachol- and substance P (SP)-induced myogenic contractions. Distribution and expression of COX isoforms in the neuromuscular compartment were assessed by RT-PCR, Western blot and immunohistochemical analysis. KEY RESULTS In control preparations, neurogenic cholinergic contractions were enhanced by COX inhibitors, whereas tachykininergic responses were blunted. Carbachol-evoked contractions were increased by indomethacin or SC-560, but not DFU, whereas all inhibitors reduced SP-induced motor responses. In preparations from DD patients, COX inhibitors did not affect electrically evoked cholinergic contractions. Both indomethacin and DFU, but not SC-560, decreased tachykininergic responses. COX inhibitors did not modify carbachol-evoked motor responses, whereas they counteracted SP-induced contractions. COX-1 expression was decreased in myenteric neurons, whereas COX-2 was enhanced in glial cells and smooth muscle. CONCLUSIONS AND IMPLICATIONS In control colon, COX-1 and COX-2 down-regulate cholinergic motility, whereas both isoforms enhance tachykininergic motor activity. In the presence of DD, there is a loss of modulation by both COX isoforms on the cholinergic system, whereas COX-2 displays an enhanced facilitatory control on tachykininergic contractile activity. PMID:24758697

  15. Toward New Horizons. Volume 10. Explosives and Terminal Ballistics

    DTIC Science & Technology

    1946-05-01

    DuBridge Dr. W. J. Sweeney Dr. Pol Duwez Dr. H. S. Tsien Dr. G. Gamow Dr. G. E. Valley Dr. I. A. Getting Dr. F. L. Wattendorf Dr. L. P. Hammett Dr. F...can be calculated, if the heat quantities for the explosive are known, and some assumptions are made concerning the equation of the state of the

  16. Hypothyroidism as a predictive clinical marker of better treatment response to sunitinib therapy.

    PubMed

    Kust, Davor; Prpić, Marin; Murgić, Jure; Jazvić, Marijana; Jakšić, Blanka; Krilić, Dražena; Bolanča, Ante; Kusić, Zvonko

    2014-06-01

    Tyrosine kinase inhibitors are standard treatment in patients with metastatic renal cell carcinoma (mRCC). Several studies have indicated that side-effects including hypothyroidism may serve as potential predictive biomarkers of treatment efficacy. All patients with clear cell mRCC treated with sunitinib in the first-line setting in our Center between November 2008 and October 2013 were included. Thyroid function was assessed after every 2 cycles. Prognostic factors were tested using Cox proportional hazards model for univariate analysis. During treatment, 29.3% developed hypothyroidism, with a median of peak TSH values of 34.4 mIU/L. Patients who had both TSH >4 mIU/L and were receiving substitution therapy with levothyroxine had prolonged PFS compared to all other patients (25.3 months vs. 9.0 months; p=0.042). The rate of hypothyroidism as a side-effect of sunitinib in patients with mRCC is significant. Patients with symptomatic hypothyroidism experienced significantly longer PFS, but without difference in OS. Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  17. Prognostic nutritional index is associated with survival after total gastrectomy for patients with gastric cancer.

    PubMed

    Ishizuka, Mitsuru; Oyama, Yusuke; Abe, Akihito; Tago, Kazuma; Tanaka, Genki; Kubota, Keiichi

    2014-08-01

    To investigate the influence of clinical characteristics including nutritional markers on postoperative survival in patients undergoing total gastrectomy (TG) for gastric cancer (GC). One hundred fifty-four patients were enrolled. Uni- and multivariate analyses using the Cox proportional hazard model were performed to explore the most valuable clinical characteristic that was associated with postoperative survival. Multivariate analysis using twelve clinical characteristics selected from univariate analyses revealed that age (≤ 72/>72), carcinoembryonic antigen (≤ 20/>20) (ng/ml), white blood cell count (≤ 9.5/>9.5) (× 10(3)/mm(3)), prognostic nutritional index (PNI) (≤ 45/>45) and lymph node metastasis (negative/positive) were associated with postoperative survival. Kaplan-Meier analysis and log-rank test showed that patients with higher PNI (>45) had a higher postoperative survival rate than those with lower PNI (≤ 45) (p<0.001). PNI is associated with postoperative survival of patients undergoing TG for GC and is able to divide such patients into two independent groups before surgery. Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  18. Associations Between PET Textural Features and GLUT1 Expression, and the Prognostic Significance of Textural Features in Lung Adenocarcinoma.

    PubMed

    Koh, Young Wha; Park, Seong Yong; Hyun, Seung Hyup; Lee, Su Jin

    2018-02-01

    We evaluated the association between positron emission tomography (PET) textural features and glucose transporter 1 (GLUT1) expression level and further investigated the prognostic significance of textural features in lung adenocarcinoma. We evaluated 105 adenocarcinoma patients. We extracted texture-based PET parameters of primary tumors. Conventional PET parameters were also measured. The relationships between PET parameters and GLUT1 expression levels were evaluated. The association between PET parameters and overall survival (OS) was assessed using Cox's proportional hazard regression models. In terms of PET textural features, tumors expressing high levels of GLUT1 exhibited significantly lower coarseness, contrast, complexity, and strength, but significantly higher busyness. On univariate analysis, the metabolic tumor volume, total lesion glycolysis, contrast, busyness, complexity, and strength were significant predictors of OS. Multivariate analysis showed that lower complexity (HR=2.017, 95%CI=1.032-3.942, p=0.040) was independently associated with poorer survival. PET textural features may aid risk stratification in lung adenocarcinoma patients. Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  19. WIS Implementation Study Report. Volume 1. Main Report.

    DTIC Science & Technology

    1983-10-01

    Luenberger, Prof. David G. * Stanford University Ries, Dr. Daniel R. * Computer Corporation of America Schill, John Naval Ocean Systems Center Shrier , Dr...Robert E. 43 Kaczmarek, Dr. Thomas S. 45 Klein, Dr. Stanely A. 47 Kramer, Dr. John F. 49 Larsen, Dr. Robert E. 55 Luenberger, Prof. David G. 58...Riddle, Dr. William E. 76 Ries, Dr. Daniel R. 82 Sapp, Mr. John W. 88 Shelley, Mr. Stephen H. 89 Shrier , Dr. Stefan 94 Slusarczuk, Dr. Marko M.G. 96

  20. Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice.

    PubMed

    Kim, Joohwee; Vaish, Vivek; Feng, Mingxiao; Field, Kevin; Chatzistamou, Ioulia; Shim, Minsub

    2016-10-07

    Cyclooxygenase (COX) is a key enzyme in the biosynthesis of prostanoids, lipid signaling molecules that regulate various physiological processes. COX2, one of the isoforms of COX, is highly inducible in response to a wide variety of cellular and environmental stresses. Increased COX2 expression is thought to play a role in the pathogenesis of many age-related diseases. COX2 expression is also reported to be increased in the tissues of aged humans and mice, which suggests the involvement of COX2 in the aging process. However, it is not clear whether the increased COX2 expression is causal to or a result of aging. We have now addressed this question by creating an inducible COX2 transgenic mouse model. Here we show that post-natal expression of COX2 led to a panel of aging-related phenotypes. The expression of p16, p53, and phospho-H2AX was increased in the tissues of COX2 transgenic mice. Additionally, adult mouse lung fibroblasts from COX2 transgenic mice exhibited increased expression of the senescence-associated β-galactosidase. Our study reveals that the increased COX2 expression has an impact on the aging process and suggests that modulation of COX2 and its downstream signaling may be an approach for intervention of age-related disorders.

  1. Cyclooxygenases in human and mouse skin and cultured human keratinocytes: association of COX-2 expression with human keratinocyte differentiation

    NASA Technical Reports Server (NTRS)

    Leong, J.; Hughes-Fulford, M.; Rakhlin, N.; Habib, A.; Maclouf, J.; Goldyne, M. E.

    1996-01-01

    Epidermal expression of the two isoforms of the prostaglandin H-generating cyclooxygenase (COX-1 and COX-2) was evaluated both by immunohistochemistry performed on human and mouse skin biopsy sections and by Western blotting of protein extracts from cultured human neonatal foreskin keratinocytes. In normal human skin, COX-1 immunostaining is observed throughout the epidermis whereas COX-2 immunostaining increases in the more differentiated, suprabasilar keratinocytes. Basal cell carcinomas express little if any COX-1 or COX-2 immunostaining whereas both isozymes are strongly expressed in squamous cell carcinomas deriving from a more differentiated layer of the epidermis. In human keratinocyte cultures, raising the extracellular calcium concentration, a recognized stimulus for keratinocyte differentiation, leads to an increased expression of both COX-2 protein and mRNA; expression of COX-1 protein, however, shows no significant alteration in response to calcium. Because of a recent report that failed to show COX-2 in normal mouse epidermis, we also looked for COX-1 and COX-2 immunostaining in sections of normal and acetone-treated mouse skin. In agreement with a previous report, some COX-1, but no COX-2, immunostaining is seen in normal murine epidermis. However, following acetone treatment, there is a marked increase in COX-1 expression as well as the appearance of significant COX-2 immunostaining in the basal layer. These data suggest that in human epidermis as well as in human keratinocyte cultures, the expression of COX-2 occurs as a part of normal keratinocyte differentiation whereas in murine epidermis, its constitutive expression is absent, but inducible as previously published.

  2. Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rimon, Gilad; Sidhu, Ranjinder S.; Lauver, D. Adam

    Pain associated with inflammation involves prostaglandins synthesized from arachidonic acid (AA) through cyclooxygenase-2 (COX-2) pathways while thromboxane A{sub 2} formed by platelets from AA via cyclooxygenase-1 (COX-1) mediates thrombosis. COX-1 and COX-2 are both targets of nonselective nonsteroidal antiinflammatory drugs (nsNSAIDs) including aspirin whereas COX-2 activity is preferentially blocked by COX-2 inhibitors called coxibs. COXs are homodimers composed of identical subunits, but we have shown that only one subunit is active at a time during catalysis; moreover, many nsNSAIDS bind to a single subunit of a COX dimer to inhibit the COX activity of the entire dimer. Here, we reportmore » the surprising observation that celecoxib and other coxibs bind tightly to a subunit of COX-1. Although celecoxib binding to one monomer of COX-1 does not affect the normal catalytic processing of AA by the second, partner subunit, celecoxib does interfere with the inhibition of COX-1 by aspirin in vitro. X-ray crystallographic results obtained with a celecoxib/COX-1 complex show how celecoxib can bind to one of the two available COX sites of the COX-1 dimer. Finally, we find that administration of celecoxib to dogs interferes with the ability of a low dose of aspirin to inhibit AA-induced ex vivo platelet aggregation. COX-2 inhibitors such as celecoxib are widely used for pain relief. Because coxibs exhibit cardiovascular side effects, they are often prescribed in combination with low-dose aspirin to prevent thrombosis. Our studies predict that the cardioprotective effect of low-dose aspirin on COX-1 may be blunted when taken with coxibs.« less

  3. Flow cytometric analysis of platelet cyclooxygenase-1 and -2 and surface glycoproteins in patients with immune thrombocytopenia and healthy individuals.

    PubMed

    Rubak, Peter; Kristensen, Steen D; Hvas, Anne-Mette

    2017-06-01

    Immature platelets may contain more platelet enzymes such as cyclooxygenase (COX)-1 and COX-2 than mature platelets. Patients with immune thrombocytopenia (ITP) have a higher fraction of immature platelets and can therefore be utilized as a biological model for investigating COX-1 and COX-2 platelet expression. The aims were to develop flow cytometric assays for platelet COX-1 and COX-2 and to investigate the COX-1 and COX-2 platelet expression, platelet turnover, and platelet glycoproteins in ITP patients (n = 10) compared with healthy individuals (n = 30). Platelet count and platelet turnover parameters (mean platelet volume (MPV), immature platelet fraction (IPF), and immature platelet count (IPC)) were measured by flow cytometry (Sysmex XE-5000). Platelet COX-1, COX-2, and the glycoproteins (GP)IIb, IX, Ib, Ia, and IIIa were all analyzed by flow cytometry (Navios) and expressed as median fluorescence intensity. COX analyses were performed in both whole blood and platelet rich plasma (PRP), whereas platelet glycoproteins were analyzed in whole blood only. ITP patients had significantly lower platelet count (55 × 10 9 /L) than healthy individuals (240 × 10 9 /L, p < 0.01), but a higher MPV (p = 0.03) and IPF (p < 0.01). IPC was similar for the two groups (p = 0.74). PRP had significantly lower MPV (p < 0.01) and significantly higher platelet count and IPC (both p-values <0.03) when compared with whole blood. IPF was similar for PRP and whole blood (p = 0.18). COX-1 expression was 10 times higher and COX-2 expression was 50% higher in PRP than in whole blood (p COX-1 < 0.01, p COX-2 < 0.01). Platelet COX-1 expression was higher in ITP patients than healthy individuals using whole blood (p COX-1 < 0.01) and PRP, though this was nonsignificant in PRP (p COX-1 = 0.17). In ITP patients, positive correlations were found between platelet turnover and COX-1 expression (all p-values <0.01, rho = 0.80-0.94), whereas healthy individuals showed significant though weaker correlations between platelet turnover and COX-1 and COX-2 expressions (all p-values <0.03, rho = 0.44-0.71). GPIIb, IX, and Ib expression was increased in ITP patients compared with healthy individuals (all p-values < 0.03). GPIIb, IX, Ib, and IIIa showed positive correlations with platelet turnover in ITP patients (all p-values <0.02, rho = 0.71-0.94), but weak and nonsignificant correlations in healthy individuals (all p-values >0.14, rho = 0.11-0.28). In conclusion, ITP patients expressed higher COX-1 and platelet glycoprotein levels than healthy individuals. COX-1 and platelet glycoproteins demonstrated positive correlations with platelet turnover in ITP patients. In healthy individuals, COX-1 and COX-2 expression correlated positively with platelet turnover. PRP was more sensitive compared with whole blood as regards determination of COX. Therefore, PRP is the recommended matrix for investigating COX-1 and COX-2 in platelets.

  4. In Silico Analysis of the Potential of the Active Compounds Fucoidan and Alginate Derived from Sargassum Sp. as Inhibitors of COX-1 and COX-2

    PubMed Central

    Dewi, Lestari

    2016-01-01

    Introduction: The enzyme cyclooxygenase (COX) is an enzyme that catalyzes the formation of one of the mediators of inflammation, the prostaglandins. Inhibition of COX allegedly can improve inflammation-induced pathological conditions. Aim: The purpose of the present study was to evaluate the potential of Sargassum sp. components, Fucoidan and alginate, as COX inhibitors. Material and methods: The study was conducted by means of a computational (in silico) method. It was performed in two main stages, the docking between COX-1 and COX-2 with Fucoidan, alginate and aspirin (for comparison) and the analysis of the amount of interactions formed and the residues directly involved in the process of interaction. Results: Our results showed that both Fucoidan and alginate had an excellent potential as inhibitors of COX-1 and COX-2. Fucoidan had a better potential as an inhibitor of COX than alginate. COX inhibition was expected to provide a more favorable effect on inflammation-related pathological conditions. Conclusion: The active compounds Fucoidan and alginate derived from Sargassum sp. were suspected to possess a good potential as inhibitors of COX-1 and COX-2. PMID:27594740

  5. In Silico Analysis of the Potential of the Active Compounds Fucoidan and Alginate Derived from Sargassum Sp. as Inhibitors of COX-1 and COX-2.

    PubMed

    Dewi, Lestari

    2016-06-01

    The enzyme cyclooxygenase (COX) is an enzyme that catalyzes the formation of one of the mediators of inflammation, the prostaglandins. Inhibition of COX allegedly can improve inflammation-induced pathological conditions. The purpose of the present study was to evaluate the potential of Sargassum sp. components, Fucoidan and alginate, as COX inhibitors. The study was conducted by means of a computational (in silico) method. It was performed in two main stages, the docking between COX-1 and COX-2 with Fucoidan, alginate and aspirin (for comparison) and the analysis of the amount of interactions formed and the residues directly involved in the process of interaction. Our results showed that both Fucoidan and alginate had an excellent potential as inhibitors of COX-1 and COX-2. Fucoidan had a better potential as an inhibitor of COX than alginate. COX inhibition was expected to provide a more favorable effect on inflammation-related pathological conditions. The active compounds Fucoidan and alginate derived from Sargassum sp. were suspected to possess a good potential as inhibitors of COX-1 and COX-2.

  6. Beyond Charity: Partial Narratives as a Metaphor for Basic Writing

    ERIC Educational Resources Information Center

    Flores, Nelson

    2010-01-01

    In "A New World: Redefining the Legacy of Min-Zhan Lu"(JBW 27.2, Fall 2008), Brian Ray revisits the controversy that emerged in the early 1990s in response to critiques of the iconic Mina Shaughnessy made by Min-Zhan Lu. He offers a reading of the debate that focuses on common ground between the two sides through a metaphor of linguistic charity…

  7. Moving Clocks Do Not Always Appear to Slow down: Don't Neglect the Doppler Effect

    ERIC Educational Resources Information Center

    Wang, Frank

    2013-01-01

    In popular accounts of the time dilation effect in Einstein's special relativity, one often encounters the statement that moving clocks run slow. For instance, in the acclaimed PBS program "NOVA," Professor Brian Greene says, "[I]f I walk toward that guy... he'll perceive my watch ticking slower." Also in his earlier piece for The New York Times,…

  8. Bulgarian Modern Poetry [and] Dracula - Fact and Fiction, for a Western World Literature Class. Fulbright-Hays Summer Seminars Abroad, 1997. (Romania and Bulgaria).

    ERIC Educational Resources Information Center

    Rang, Barbara L.

    This project developed two units for secondary students, one dealing with the modern poetry of Bulgaria and one with the legend of Dracula. The first unit includes poems, discussion questions, and a background essay. The second unit includes discussion materials largely based on Brian Stoker's novel "Dracula," and an historical essay on…

  9. Agriculture and stability in Afghanistan

    DTIC Science & Technology

    2009-05-21

    national wealth are due to good political institutions. 16 He believes that geographical factors, including disproportionate disease burdens on human... Celia W. Dugger, “Ending Famine, Simply by Ignoring the Experts,” New York Times, December 2, 2007. 87 Dugger, Ending Famine, p 1. 88 J. Brian Atwood...is multidimensional, as well as a symptom of insecurity, corruption and poor governance. The Islamic Government of Afghanistan describes the opium

  10. Assessing the Strategic Utility of the High North: The Colder War

    DTIC Science & Technology

    2016-12-01

    FUNDING NUMBERS 6. AUTHOR(S) Brandon J. Daigle and Brian W. James 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School...Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING AGENCY NAME(S) AND ADDRESS(ES) N/A 10. SPONSORING...European Command GDP Gross domestic product ISR Intelligence, surveillance and reconnaissance NATO North Atlantic Treaty Organization NSR Northern

  11. The Army Lawyer

    DTIC Science & Technology

    2007-07-01

    Ratification, Implementation of Existing Conventions, U.N. Doc. SG/SM/799 (Oct. 22, 2001). 161 Thierry Tardy , The Inherent Difficulties of...Barbary Coast;32 pacified the Western Frontier;33 fought rebels in the Philippines ;34 conducted constabulary missions in Cuba, Panama, and Nicaragua;35...34 BRIAN MCALLISTER LINN, THE U.S. ARMY AND COUNTERINSURGENCY IN THE PHILIPPINE WAR 1899-1902 (2000). 35 LESTER D. LANGELY, THE UNITED STATES AND

  12. NATO and U.S. Ballistic Missile Defense Programs: Divergent or Convergent Paths?

    DTIC Science & Technology

    2008-12-01

    PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING AGENCY NAME(S) AND ADDRESS(ES) N /A 10. SPONSORING/MONITORING AGENCY...Gray, 280. 36 n alliances. insecurity are the norm and periods of peace are more akin to interwar...Destruction, ed. Janne E. Nolan, Bernard I. Finel and Brian D. Finlay (New York: Century Foundation Press, 2003), 204. 118 “Iran,” The European

  13. New England Wind Forum: A Wind Powering America Project, Volume 1, Issue 4 -- May 2008 (Newsletter)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Grace, R. C.; Gifford, J.

    2008-05-01

    The New England Wind Forum electronic newsletter summarizes the latest news in wind energy development activity, markets, education, and policy in the New England region. It also features an interview with a key figure influencing New England's wind energy development. Volume 1, Issue 4 features an interview with Brian Fairbank, president and CEO of Jiminy Peak Mountain Resort.

  14. NCI at Frederick Employees Receive Awards at the Spring Research Festival | Poster

    Cancer.gov

    NCI and Frederick National Laboratory staff members were among those honored at the Spring Research Festival Awards Ceremony on May 28. The ceremony was the culmination of the festival, which was sponsored by the National Interagency Confederation for Biological Research (NICBR), May 4–7. Maj. Gen. Brian Lein, commanding general, U.S. Army Medical Research and Materiel Command (USAMRMC), presented the awards.

  15. Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (PME) (24th, Hiroshima, Japan, July 23-27, 2000), Volume 3.

    ERIC Educational Resources Information Center

    Nakahara, Tadao, Ed.; Koyama, Masataka, Ed.

    The third volume of the 24th annual conference of the International Group for the Psychology of Mathematics Education contains full research report papers. Papers include: (1) "Mathematics classrooms functioning as communities of inquiry: Possibilities and constraints for changing practice" (Susie Groves, Brian Doig, and Laurance Splitter); (2)…

  16. Once the Beat Gets Going It Really Grooves: Informal Music Learning as Experienced by Two Irish Traditional Musicians

    ERIC Educational Resources Information Center

    Waldron, Janice

    2007-01-01

    The purpose of this ethnographic case study was to discover the manner in which two Irish musicians, Loretto Reid and Brian Taheny, taught/and or transmitted traditional music at the Celtic College Summer School in Goderich, Ontario. Two central questions, each followed by several sub-questions, served to focus the study: "How did you learn…

  17. Model-Based Reasoning in the Detection of Satellite Anomalies

    DTIC Science & Technology

    1990-12-01

    Conference on Artificial Intellegence . 1363-1368. Detroit, Michigan, August 89. Chu, Wei-Hai. "Generic Expert System Shell for Diagnostic Reasoning... Intellegence . 1324-1330. Detroit, Michigan, August 89. de Kleer, Johan and Brian C. Williams. "Diagnosing Multiple Faults," Artificial Intellegence , 32(1): 97...Benjamin Kuipers. "Model-Based Monitoring of Dynamic Systems," Proceedings of the Eleventh Intematianal Joint Conference on Artificial Intellegence . 1238

  18. Preparing for the Worst-Case Scenario--Planning Pays Off with First-Ever Stadium Evacuation

    ERIC Educational Resources Information Center

    Bradley, Carol C.

    2012-01-01

    It's Saturday, September 3, Notre Dame vs. South Florida--the first home game of the season--and nearing halftime. The only person feeling more pressure than Head Coach Brian Kelly is Mike Seamon, associate vice president for campus safety and director of game day operations. Bad weather is on the way, and he's about to make the call to evacuate…

  19. An Enterprise Model of Rising Ship Costs: Loss of Learning Due to Time between Ships and Labor Force Instability

    DTIC Science & Technology

    2007-04-30

    CAIGOSD CAIG/NAVYDDG/abbr LHDMr. Gary Bliss, Mr. Chris Deegan , Mr. Ed Foster, Mr. Brian Cuccias Oct 7, 2005 OSD CAIG, LHA 6 PMOSD CAIG/NAVYDDG/LHDLTC...Chris Deegan / Capt. Rich HooperSept 7, 2005 -SCEAALM 3ISPA/SCEA 2007Jun 12, 2007 Corporate DirectorNG HQDDGMs. Patti Tisone & NG Pricing CouncilSept 22

  20. Propagation of Statistical Noise Through a Two-Qubit Maximum Likelihood Tomography

    DTIC Science & Technology

    2018-04-01

    University Daniel E Jones, Brian T Kirby, and Michael Brodsky Computational and Information Sciences Directorate, ARL Approved for...collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources...gathering and maintaining the data needed, and completing and reviewing the collection information . Send comments regarding this burden estimate or any other

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