An Annotated Bibliography of MANPRINT-Related Assessments and Evaluations Conducted by the U.S. Army, 2nd Edition: 1953 to 2009. Volume 3 - Test and Evaluation Reports

DTIC Science & Technology

2010-02-01

bibliography of the 583 MA reports reviewed by this paper . MANPRINT Asssessments are performed according to the direction of AR 602-2. They consist of an...bibliography of the 443 T&ERs reviewed by this paper . A T&ER is a system evaluation performed according to AR 73-1 for all systems in development in the...of the Defense Technical Information Center (DTIC) web page: https://dtic-stinet.dtic.mil/.  National Technical Information Service (NTIS): http

The DoD Gateway Information System: Bibliography, Directory of Resources, Prototype Experience, [and] User Interface Design.

ERIC Educational Resources Information Center

Cotter, Gladys A.; And Others

The Defense Technical Information Center (DTIC), an organization charged with providing information services to the Department of Defense (DoD) scientific and technical community, actively seeks ways to promote access to and utilization of scientific and technical information (STI) databases, online services, and networks relevant to the conduct…

The Shared Bibliographic Input Network (SBIN): A Summary of the Experiment.

ERIC Educational Resources Information Center

Cotter, Gladys A.

As part of its mission to provide centralized services for the acquisition, storage, retrieval, and dissemination of scientific and technical information (STI) to support Department of Defense (DoD) research, development, and engineering studies programs, the Defense Technical Information Center (DTIC) sponsors the Shared Bibliographic Input…

Integrated Bibliographic Information System: Integrating Resources by Integrating Information Technologies.

ERIC Educational Resources Information Center

Cotter, Gladys A.; Hartt, Richard W.

The Defense Technical Information Center (DTIC), an organization charged with providing information services to the Department of Defense (DoD) scientific and technical community, actively seeks ways to promote resource sharing as a means for speeding access to information while reducing the costs of information processing throughout the technical…

Development of a Torque Sensor-Based Test Bed for Attitude Control System Verification and Validation

DTIC Science & Technology

2017-12-30

from the Defense Technical Information Center (DTIC) (http://www.dtic.mil). AFRL-RV-PS-TR-2018-0008 HAS BEEN REVIEWED AND IS APPROVED FOR...report is published in the interest of scientific and technical information exchange, and its publication does not constitute the Government’s approval... information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and

A PLATFORM FOR CONTEXTUAL MOBILE PRIVACY

DTIC Science & Technology

2017-12-01

cen- tralizes all permission management functionality. “Streamline the interface to require less touches to find the information about permissions...APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED STINFO COPY AIR FORCE RESEARCH LABORATORY INFORMATION DIRECTORATE...public, including foreign nationals. Copies may be obtained from the Defense Technical Information Center (DTIC) (http://www.dtic.mil). AFRL

The Integrated Bibliographic Information System: Resource Sharing Tailored for Local Needs.

ERIC Educational Resources Information Center

Cotter, Gladys A.; Hartt, Richard W.

The Defense Technical Information Center (DTIC), which is charged with providing information services to the scientific and technical community of the Department of Defense (DoD), actively seeks ways to promote resource sharing as a means for speeding access to information while reducing the costs of information processing throughout the defense…

Organizational structure and operation of defense/aerospace information centers in the United States of America

NASA Technical Reports Server (NTRS)

Sauter, H. E.; Lushina, L. N.

1983-01-01

U.S. Government aerospace and defense information centers are addressed. DTIC and NASA are described in terms of their history, operational authority, information services provided, user community, sources of information collected, efforts under way to improve services, and external agreements regarding the exchange of documents and/or data bases. Contents show how DTIC and NASA provide aerospace/defense information services in support of U.S. research and development efforts. In a general introduction, the importance of scientific and technical information and the need for information centers to acquire, handle, and disseminate it are stressed.

Feasibility Study for a Computerized Serials Control System in the Defense Communications Agency Technical and Management Information Center.

DTIC Science & Technology

1984-06-20

AD-A162 ±88 FEASIBILITY STUDY FOR A COMPUTERIZED SERIALS CONTROL 1/1 SYSTEM IN THE DEFENS (U) DEFENSE COMMUNICATIONS AGENCY WASHINGTON DC TECHNICAL...NATIONAL BUREAU OF STANDARDS- 1963-A 0FEASIBILITY STUDY FOR A COMPUTERIZED SERIALS CONTROL SYSTEM IN THE DEFENSE COMMUNICATIONS 0AGENCY TECHNICAL AND...ABSTRACT 21. ABSTRACT SECURITY CLASSIFICATION UNCLASSIFIED/UNLIMITED R1 SAME AS RPT. 0 DTIC USERS 0 UNCLASSIFIED 22&. NAME OF RESPONSIBLE INDIVIDUAL 22b

Thermal Transport in Diamond Films for Electronics Thermal Management

DTIC Science & Technology

2018-03-01

AFRL-RY-WP-TR-2017-0219 THERMAL TRANSPORT IN DIAMOND FILMS FOR ELECTRONICS THERMAL MANAGEMENT Samuel Graham Georgia Institute of Technology MARCH...general public, including foreign nationals. Copies may be obtained from the Defense Technical Information Center (DTIC) (http://www.dtic.mil...Signature// JOHN D. BLEVINS, Program Manager ROSS W. DETTMER, Chief Devices for Sensing Branch Devices for Sensing Branch Aerospace Components

The DTIC Review: Volume 2, Number 4, Surviving Chemical and Biological Warfare

DTIC Science & Technology

1996-12-01

CHROMATOGRAPHIC ANALYSIS, NUCLEAR MAGNETIC RESONANCE, INFRARED SPECTROSCOPY , ARMY RESEARCH, DEGRADATION, VERIFICATION, MASS SPECTROSCOPY , LIQUID... mycotoxins . Such materials are not attractive as weapons of mass destruction however, as large amounts are required to produce lethal effects. In...VERIFICATION, ATOMIC ABSORPTION SPECTROSCOPY , ATOMIC ABSORPTION. AL The DTIC Review Defense Technical Information Center AD-A285 242 AD-A283 754 EDGEWOOO

Aircraft Handling Qualities Data

DTIC Science & Technology

1972-12-01

WITH YOUR INQUIRY 02672-931227121247 DEPT OF DEFENSE DEFENSE TECHNICAL INFORMATION CENTER ATTN: DTIC-OCP/JOYCE CHIRAS CAMERON STATION BLDG 9...Handling Qualities, F-IO4A, Lockheed Rept. t No. LR 10794, 12 Dec. 19ř Andrews, William H., and Herman A. Rediess, Flight-Determined Eta- bility and

Foreign Language Analysis and Recognition (FLARE) Progress

DTIC Science & Technology

2015-02-01

Copies may be obtained from the Defense Technical Information Center (DTIC) (http://www.dtic.mil). AFRL- RH -WP-TR-2015-0007 HAS BEEN REVIEWED AND IS... retrieval (IR). 15. SUBJECT TERMS Automatic speech recognition (ASR), information retrieval (IR). 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF...to the Haystack Multilingual Multimedia Information Extraction and Retrieval (MMIER) system that was initially developed under a prior work unit

Instant Foundry Adaptive through Bits (iFAB)

DTIC Science & Technology

2012-07-01

Critical Technologies JULY 2012 Final Report Approved for public release; distribution unlimited. See additional restrictions described on inside...or permission to manufacture, use, or sell any patented invention that may relate to them. This report was cleared for public release by the...requestors may obtain copies of this report from the Defense Technical Information Center (DTIC) (http://www.dtic.mil). AFRL-RX-WP-TR-2012-0359 HAS

Effects of Variable Spot Size on Human Exposure to 95 GHz Millimeter Wave Energy

DTIC Science & Technology

2017-05-11

AFRL -RH-FS-TR-2017-0017 Effects of Variable Spot Size on Human Exposure to 95-GHz Millimeter Wave Energy James E. Parker Eric J. Nelson...Defense Technical Information Center (DTIC) (http://www.dtic.mil). ( AFRL -RH-FS- - - ) has been reviewed and is approved for publication in accordance with...REPORT NUMBER(S) AFRL -RH-FS-TR-2017-0017 12. DISTRIBUTION / AVAILABILITY STATEMENT Distribution A: Approved for public release; distribution

The DTIC Review. Volume 5, Number 2. Real-Time Communications

DTIC Science & Technology

2000-12-01

appreciate your comments. Kurt N. Molholm Administrator THIS PAGE INTENTIONALLY LEFT BLANK The DTIC Review Defense Technical Information Center TABLE OF...assisted by Captain Dino Perone, CW2 Kurt Prokarym, CW2 Earl Johnson, SSG Case, MSG Nancy MacDonald, SGM Jessie Husband, and many other junior non...Navy IT-21 Audit Policy 07 Jul 2000 28 PAGES 01 Sep 1999 61 PAGES PERSONAL AUTHORS: Gevelber, Michael; PERSONAL AUTHORS: Kremer , H. S. Wroblewski

A Review of Central Nervous System (CNS)/Cognitive Effects Due to Blast

DTIC Science & Technology

2007-02-01

head trauma: is brain damage overdiagnosed ? Part 1. J Clin Neurosci, 7(5), 400-8. Mayorga, M. A. (1997). The pathology of primary blast overpressure...Office and is available to the general public, including foreign nationals. Copies may be obtained from the Defense Technical Information Center (DTIC...http://www.dtic.mil). AFRL-RH-BR-TR-2007-0072 has been reviewed and is approved for publication in accordance with assigned distribution

A Delicate Balance: National Security vs. Public Access

ERIC Educational Resources Information Center

Klein, Bonnie; Schwalb, Sandy

2005-01-01

Sometimes people want to see data that the government thinks should be kept under wraps. How does the Department of Defense balance the scales of justice while still ensuring information security? In the aftermath of September 11, 2001, the Defense Technical Information Center (DTIC) found itself in the spotlight as journalists, academics, and…

DTIC (Defense Technical Information Center) Model Action Plan for Incorporating DGIS (DOD Gateway Information System) Capabilities.

DTIC Science & Technology

1986-05-01

Information System (DGIS) is being developed to provide the DD crmjnj t with a modern tool to access diverse dtabaiees and extract information products...this community with a modern tool for accessing these databases and extracting information products from them. Since the Defense Technical Information...adjunct to DROLS xesults. The study , thereor. centerd around obtaining background information inside the unit on that unit’s users who request DROLS

Hypermedia Laboratory, Defense Applied Information Technology Center; Review for 1988

DTIC Science & Technology

1988-12-01

Information System (DGIS): The Department of Defense Microcomputer User’s Gateway to the World;" Microcomputers for Information Management : An International...accessing. "Knowledge Gateways: The Building Blocks." Information Processing & Management , Volume 24, Number 4, pp. 459-468, 1988. Donald T. Hawkins...intelligence and hypermedia. This activity is managed by the Defense Technical Information Center (DTIC). Much of our development at this point is

Testing of Mortar Systems

DTIC Science & Technology

2010-03-11

IEP /TDP) or Independent Assessment Plan (IAP), and the test item and the procedures as outlined in this TOP. The following must also be considered...Command DTIC = Defense Technical Information Center DTP = Detailed Test Plan IAP = Independent Assessment Plan IEP = Independent Evaluation Plan IPT

Moka with Ristretto

DTIC Science & Technology

2017-11-01

MOKA WITH RISTRETTO ASSURED INFORMATION SECURITY, INC. NOVEMBER 2017 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED...STINFO COPY AIR FORCE RESEARCH LABORATORY INFORMATION DIRECTORATE AFRL-RI-RS-TR-2017-223  UNITED STATES AIR FORCE  ROME, NY 13441 AIR FORCE...report is available to the general public, including foreign nations. Copies may be obtained from the Defense Technical Information Center (DTIC

Total Quality Management Implementation at the Defense Technical Information Center

DTIC Science & Technology

1989-09-01

industry user groups, as well as the contracting process to emphasize the benefits of TQM to the private sector . 5. Demonstrate an Uncompromising... worklife enhancements are important elements in creating the environment in which DTIC personnel will grow, gain new experiences and capabilities, and

Proceedings of the CASE Adoption Workshop Held in Pittsburgh, Pennsylvania on 13-14 November 1990

DTIC Science & Technology

1992-05-01

position. It Is published in the interest of scientific and technical information exchange. Review and Approval This report has been reviewed and is...available through the Defense Technical Information Center. DTIC provides access so and transr of scientific and technical information for DoD... Metthods and Tools $1,850 P-Cube Corporation 572 East Lamibert Rd CASEbase (a PC-based CASE database) $495 Brea, CA 92621 (714) 990-3169 Foresite

An Operational System for Subject Switching between Controlled Vocabularies.

ERIC Educational Resources Information Center

Silvester, June P.; Klingbiel, Paul H.

1993-01-01

Describes a system developed at the National Aeronautics and Space Administration (NASA) that automatically converts index terms from the Defense Technical Information Center (DTIC) to NASA thesaurus terms. The NASA Lexical Dictionary (NLD) that generates thesaurus terms for indexing is explained, and the development of machine-aided indexing is…

Second Generation Weather Impacts Decision Aid User’s Manual

DTIC Science & Technology

2013-09-01

from the pulldown Base Reference Time menu. Most models start at times based on Coordinated Universal Time (UTC) or Zulu time (Z) with the selections...Effects Matrix Z Zulu time 31 No. of Copies Organization 1 DEFENSE TECHNICAL (PDF) INFORMATION CTR DTIC OCA 1 DIRECTOR (PDF) US

Disaster Response Preparedness and Training: A Capabilities Assessment of the Asia Pacific Military Health Exchange

DTIC Science & Technology

2018-02-01

that may relate to them. Qualified requestors may obtain copies of this report from the Defense Technical Information Center (DTIC) (http...report is published in the interest of scientific and technical information exchange, and its publication does not constitute the Government’s...collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources

Alpena, Michigan. Revised Uniform Summary of Surface Weather Observations. Parts A-F.

DTIC Science & Technology

1987-10-01

Rpoirt, Nober: USAFETACDS-87/059. 5. *mitorma Organization Report Nuber: USAIETAC/DS-87/059. Ga. Obaf of Performin Oranization: USAFETAC/OL-A Sb. Office...description of contents and Instructions for ue.- 20 DistrIbutieel/vmilability of Abstract: Same as report . 21 Abstract Security Clasalficatiem...large, or by the Defense Technical Information Center (DTIC) to the National Technical Information Service (NTIS). This document has been reviewed and

Defense Technical Information Center Thesaurus

DTIC Science & Technology

2000-10-01

acquisition radar 4 + Indicates existence of further generic levels of the term DTIC Thesaurus Actuators Acridines Actinide series (cont.) Activated sintering...BT Heterocyclic compounds+ Uranium+ BT Sintering Acrilan Actinide series compounds Activated sludge process use Acrylonitrile polymers RT Actinide...Waste treatment+ Protactinium compounds Acronyms Thorium compounds+ Activation use Abbreviations Transuranium compounds+ UF Energizing Uranium compounds

Investigation of Visual Performance after Administration of Cholinergic Blocking Agents. I. Benactyzine.

DTIC Science & Technology

1980-03-01

L.F., and Gillespie, H.K. (1971). Marihuana and the temporal span of awareness. Arch. Gen. Psychiat.,24,564-567. Masland, R.H. (1979) in Symposium 106...Defense Technical Information Center (rTIC) ATTN: DTIC-DDA Cameron Station Alexandria, VA 22314 1 copy Dean School of Medicine Uniformed Services

Executive Competencies and Skills Required by United States Coast Guard Health Care Administrators

DTIC Science & Technology

1999-08-01

into the 219t Century - Defense Technical Information Center, May 95 1996 Medical Service Corps Vision 21: Behavior for Career Success in the 2 1st...21: Behavior for Career Success in the 21st Century. Academy of Health Services (Army) Fort Sam Houston, TX: (DTIC no. ADA310081). FT Belvoir, VA

Proceedings of the 1985 Annual DTIC (Defense Technical Information Center) Users Conference Held in Alexandria, Virginia on 23-25 October 1985

DTIC Science & Technology

1985-10-01

Donovan Space Communications Company 1300 Quince Orchard Boulevard Gaithersburg, MD 20878 Joyce H. Deegan Rockwell International Corporation 1200 N...J. P. Norton Engineered Air Systems 1270 N. Price Road St. Louis, MO 63132 Craig L. Pelz Naval Weapons Center Information Services Branch Code

Surface Observation Climatic Summaries for Myrtle Beach AFB, South Carolina.

DTIC Science & Technology

1992-02-01

UNLIMITED DISTRIBUTION OF THIS DOCUMENT TO THE PUBLIC AT LARGE, OR BY THE DEFENSE TECHNICAL INMFOM ON CENTER (DTIC) TO THE fiATICVAL TECHNICAL INFOAm9... THE oNANDER Distribution I Availability Codes SCITEN A. - .4MDist Avail andIor SCMTECHNICAL I Dt Special 2 8 S ;E 1992 d.I USA MTAC/D8--92/269 - Page...PRODUCT REPLACED TWO USAFETAC DOCUMENTS FORMERLY NNONN AS THE REVISED UNIFORM SUM=RY OF SURFACE OBSERVATIONS (RUSSTO) AND THE LIMITED SURFACE

Functions of the Department of Defense and Its Major Components

DTIC Science & Technology

2010-12-21

Information Center (DTIC),” August 19, 2005 (ax) DoD Directive 5105.72, “Defense Technology Security Administration ( DTSA ),” July 28, 2005 (ay) DoD...Information Center (DTIC). See DoDD 5105.73 (Reference (aw)). (4) Defense Technology Security Administration ( DTSA ). See DoDD 5105.72

NEON VISUALIZATION ENVIRONMENT

DTIC Science & Technology

2017-07-28

STINFO COPY AIR FORCE RESEARCH LABORATORY INFORMATION DIRECTORATE AFRL-RI-RS-TR-2017-143  UNITED STATES AIR FORCE  ROME, NY 13441 AIR FORCE...report is available to the general public, including foreign nationals. Copies may be obtained from the Defense Technical Information Center (DTIC) (http...FOR THE CHIEF ENGINEER: / S / / S / PETER A. JEDRYSIK JULIE BRICHACEK Work Unit Manager Chief, Information Systems Division Information

Study of Online Instruction Methodologies for the DTIC Training Program.

DTIC Science & Technology

1981-02-01

Lockheed Information Retrieval Service (LIRS) (2 programs) b. University of Denver Graduate School of Librarianship and Information Management (GSLIM) c...program -for a reasonably typical lecture-based academic program University of Denver Graduate School of Librarianship and Information Management (GSLIM...Lockheed Information Retrieval Service (LIRS) University of Denver Graduate School of Librarianship and Information Management (GSLIM) Defense Technical

DTIC: Your Key to DoD Scientific & Technical Information

DTIC Science & Technology

2009-06-01

DTIC Online Unclassified on SIPRNET • DTIC Online Access Controlled Near Completion http://www.dtic.mil/dtic/ DTIC MultiSearch: Enhanced Federated ... Search MultiSearch – searches more than 400 DoD, federal, commercial & international S&T sources from 50 countries DTIC Online Unclassified on

32 CFR 287.6 - Duties of the DITCO and the DTIC FOIA officers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 287.6 Duties of the DITCO and the DTIC FOIA officers. (a) DITCO FOIA Officer. The...

2016 Service Academy Gender Relations Survey: Overview Report

DTIC Science & Technology

2017-02-01

2016 Service Academy Gender Relations Survey Overview Report Additional copies of this report may be obtained from: Defense Technical Information...report by DTIC # AD1029209 OPA Report No. 2016-043 February 2017 2016 SERVICE ACADEMY GENDER RELATIONS SURVEY Office of People Analytics 4800...Mark Center Drive, Suite 04E25-01 Alexandria, VA 22350-4000 2017 2016 Service Academy Gender Relations Survey DMDC | ii Acknowledgments The

2016 Service Academy Gender Relations Survey

DTIC Science & Technology

2017-02-01

2016 Service Academy Gender Relations Survey Overview Report Additional copies of this report may be obtained from: Defense Technical Information...report by DTIC # AD1029209 OPA Report No. 2016-043 February 2017 2016 SERVICE ACADEMY GENDER RELATIONS SURVEY Office of People Analytics 4800...Mark Center Drive, Suite 04E25-01 Alexandria, VA 22350-4000 2017 2016 Service Academy Gender Relations Survey DMDC | ii Acknowledgments The

Analysis of the Use of Defense Technical Information Center Resources By Research and Development Centers and Laboratories in the U.S. Army

DTIC Science & Technology

1985-11-08

and ." faster printers, they could significantly reduce problems exper- Sienced with slow turnaround for delivery of documents from DTIC. 5.35. Table...forgotten re- ports on rifle war games that proved very useful to our studies." (BRL) Saved 2 weeks and $3,000: "A new warhead development program

Symmetry- and Solvent-Dependent Photophysics of Fluorenes Containing Donor and Acceptor Groups (Postprint)

DTIC Science & Technology

2014-07-01

available to the general public, including foreign nationals. Copies may be obtained from the Defense Technical Information Center (DTIC) (http...EXPERIMENTAL SECTION Instrumentation. NMR spectra were obtained using a Bruker Avance 400 MHz spectrometer, and chemical shifts were referenced to...yields were determined using the actinometry method previously described.37 Quinine sulfate was used as an actinometer with a known fluorescence quantum

32 CFR 287.6 - Duties of the DITCO and the DTIC FOIA officers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Duties of the DITCO and the DTIC FOIA officers... INFORMATION ACT PROGRAM § 287.6 Duties of the DITCO and the DTIC FOIA officers. (a) DITCO FOIA Officer. The... duties stated in § 287.4 (d) and (h). (b) DTIC FOIA Officer. The DTIC FOIA Officer, located at 8725 John...

32 CFR 287.6 - Duties of the DITCO and the DTIC FOIA officers.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Duties of the DITCO and the DTIC FOIA officers... INFORMATION ACT PROGRAM § 287.6 Duties of the DITCO and the DTIC FOIA officers. (a) DITCO FOIA Officer. The... duties stated in § 287.4 (d) and (h). (b) DTIC FOIA Officer. The DTIC FOIA Officer, located at 8725 John...

32 CFR 287.6 - Duties of the DITCO and the DTIC FOIA officers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Duties of the DITCO and the DTIC FOIA officers... INFORMATION ACT PROGRAM § 287.6 Duties of the DITCO and the DTIC FOIA officers. (a) DITCO FOIA Officer. The... duties stated in § 287.4 (d) and (h). (b) DTIC FOIA Officer. The DTIC FOIA Officer, located at 8725 John...

32 CFR 287.6 - Duties of the DITCO and the DTIC FOIA officers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Duties of the DITCO and the DTIC FOIA officers... INFORMATION ACT PROGRAM § 287.6 Duties of the DITCO and the DTIC FOIA officers. (a) DITCO FOIA Officer. The... duties stated in § 287.4 (d) and (h). (b) DTIC FOIA Officer. The DTIC FOIA Officer, located at 8725 John...

DTIC review. Volume 1, Number 1: Nuclear proliferation and deterrence in a changing political world

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cupp, C.M.; Lee, C.; Foster, H.

1995-08-01

This collection of selected documents from the Defense Technical Information Center (DTIC) addresses the formidable issue of protecting the United States and its people from potential nuclear destruction. With the dissolution of the former Soviet Union and, concomitantly, the end of the Cold War, new strategies for nonproliferation and deterrence must be devised and implemented. Potential threats from countries not previously seen as a danger, the escalation of regional conflicts and the proliferation of weapons of mass destruction are but a few of the considerations to be addressed. The authors of the following papers propose various plans and tactics tomore » ensure United States national security and maintain world peace.« less

Applicability of existing C3 (command, control and communications) vulnerability and hardness analyses to sentry system issues. Technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, R.C.

1983-01-13

This report is a compilation of abstracts resulting from a literature search of reports relevant to Sentry Ballistic missile system C3 vulnerability and hardness. Primary sources consulted were the DOD Nuclear Information Analysis Center (DASIAC) and the Defense Technical Information Center (DTIC). Approximately 175 reports were reviewed and abstracted, including several related to computer programs for estimating nuclear effects on electromagnetic propagation. The reports surveyed were ranked in terms of their importance for Sentry C3 VandH issues.

Design of Experiments for Model Calibration of Multi-Physics Systems with Targeted Events of Interest

DTIC Science & Technology

2017-03-01

discrete set of specimen and instrumentation locations available to be studied in a high -speed tunnel, such as the 8-foot HTT, under the desired...Benjamin P. Smarslok Hypersonic Sciences Branch High Speed Systems Division Diane Villanueva Universal Technology Corporation MARCH 2017...and is available to the general public, including foreign nationals. Copies may be obtained from the Defense Technical Information Center (DTIC

Effects on Fuel Consumption and Diesel Engine Deposits from Nano-Particle Oil Additive

DTIC Science & Technology

2010-07-01

Disclaimers The findings in this report are not to be construed as an official Department of the Army position unless so designated by other...authorized documents. Trade names cited in this report do not constitute an official endorsement or approval of the use of such commercial hardware or...software. DTIC Availability Notice Qualified requestors may obtain copies of this report from the Defense Technical Information Center

Surface Observation Climatic Summaries for Nellis AFB, Nevada

DTIC Science & Technology

1992-05-01

DISTRIBUTION OF THIS DOMWI! TO THE PUBLIC AT LARGE, OR BY THE DEFENSE TECHNICAL IMKNMTI1M CENTER (DTIC) TO THE NATIOAL T•ECICRL INFO TION SERVICE (NTS). JOSEPH...DOCUMENTS FORMERLY KNOW AS THE REVISED UNIFON4 StlMMRRY OF SURFACE OBSERVATIONS (RUSSW) AND THE LIMITED SURFACE OBSERVATIONS CLIMATIC SWSU.R (LISOCS...RECORD (POR). -SUMMARY OF DAY- (SOD) INFOEATIOR IS SUMMARIZED )FRO ALL AVAILABLE DATA IN THE OL-A, USARETJC CLIMATIC DATABASE. 14. SUBJECT TOM

A Historical Study of the Effectiveness of U.S. Security Assistance to Panama, Costa Rica and Nicaragua

DTIC Science & Technology

1986-09-01

United States aid to the rebels (16:9). The United States policy toward Central America originated with the Monroe Doctrine. As explained in Chapter...crisis in the area. The most often used were Mexico and Central America Report, Latinamerica Press, Mesoamerica , and Hemisphere Hotline. Especially...Information Exchange (DLSIE) and the Defense Technical Information Center (DTIC) to determine what studies were available. In addition, the historical

NATO Scientific and Technical Information Service (NSTIS): functional description. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Molholm, K.N.; Blados, W.N.; Bulca, C.

1987-08-01

This report provides a functional description of the requirements for a NATO Scientific and Technical Information Service (NSTIS). The user requirements and much of the background information in this report were derived primarily from interviews with more than 60 NATO Headquarters staff members between 2 March and 25 March 1987. In addition, representatives of the Supreme Headquarters Applied Powers Europe (SHAPE) Technical Centre (STC), the Supreme Allied Commander Atlantic (Anti-Submarine Warfare Research) Centre (SACLANTCEN), the NATO Communications and Information Systems Agency (NACISA), The Advisory Group for Aerospace Research and Development (AGARD), the U.S. Defense Technical Information Center (DTIC), and themore » Technical Documentation Center for the Armed Forces in the Netherlands (TDCK), were interviewed, either in person or by telephone.« less

A General Retention Model Applied to the Naval Aviator.

DTIC Science & Technology

1980-06-01

California 00 ~DTIC ELE-CTE THESIS A GENERAL RETENTION MODEL APPLIED TO THE NAVAL AVIATOR by James Robert O’Donnell June 1980 ( Thesis Advisor: D . M ... Psychology , v. 62, p. 237-240, 1977. " NAVPERS 15658(A), FY-79 Annual Report , Navy Military Personnel Statistics Office, Washington, D.C., 30 September 1979... Psychology , v. 29, p. 57-60, 1976. 40 INITIAL DISTRIBUTION LIST No. Copies 1. Defense Technical Information Center 2 Cameron Station Alexandria

The Learning Curve: MACVs Grasp of Intelligence, PSYOP, and Their Coordination, 1965-1971

DTIC Science & Technology

2015-06-01

demonstrations break out on a number of US college campuses 4 May 1970 - Four students fatally shot during protest at Kent State University...Operational Art and Science from the Air Command and Staff College , and a Master’s of Philosophy in Military Strategy from the School of Advanced...Turned a Tactical Victory into a Political Defeat”, (Ft. Belvoir: Defense Technical Information Center, 2009), www.dtic.mil/cgi-bin/GetTRDoc?AD

The Role of Second Phase Intermetallic Particles on the Spall Failure of 5083 Aluminum

DTIC Science & Technology

2016-12-01

of mechanically processed 5083 aluminum (i.e., cold and hot rolled, extruded , etc.) has been previously studied by several researchers [1–4]. Results...Velocity Interferometry System for Any Reflector (VISAR) [6]. In addition, four end-state (ex situ spall recovery) experiments were conducted to augment all... extruded AMX602 Mg alloy (unpublished) J. dynamic behavior mater. (2016) 2:476–483 483 123 9 1 DEFENSE TECHNICAL (PDF) INFORMATION CTR DTIC OCA

Mobilization and Defense Management Technical Reports Series. The Use of Reactivation Networks to Improve Mobilization Preparedness of the Ammunition Industry

DTIC Science & Technology

1983-05-01

additional measures that if implemented • .could make the technique more effective . •j• . SECURITY CLASSIFICATION OF THIS PAGE t•’/en Data Ente red) qqp...preparedness, and recommends additional measures that if implemented could make the technique more effective . Accession For NTIS GRA&I DTIC .TAB...related to mobilization preparedness. I decided to limit this report to the effects of the application of VERM on the prepiredness of the ammunition

Space Launch Complex 6 Wastewater Treatment Facilities Evaluation, Vandenberg AFB, California.

DTIC Science & Technology

1987-02-01

Sgt Tammy Johnson, AiC Roberto Rolon and AlC Pete Davis without whose valuable assistance this survey could never have been accomplished. We also...lLt Francis E. Slavich, MSgt Horace C. Burbage, Sgt Tammy Johnson, AlCs Roberto Rolon and Pete Davis. The objectives of the survey were to evaluate the...TSK Brooks AFB TX 78235-5301 Defense Technical Information Center (DTIC) 2 Cameron Station Alexandria VA 22319 HQ USAF/LEEV 1 Bolling AFB DC 20330

Comparing the Effectiveness of Two KC-10 Concepts of Operation - An Examination of Tanker/Airlift Support in a Fighter Deployment to Europe

DTIC Science & Technology

1986-06-01

PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER ORGANIZATION (Ii’ ppticable) Sc. ADDRESS (City, State and ZIP Code) 10. SOURCE OF FUNDING NOS...total of 60 KC-10s were available to support the fighter deployment. This number represented the projected KC-10 procurement for the year 1990 as...search for relevant government studies was accomplished through the Defense Technical Information Center (DTIC). All their 3-9 research related to

Chernobyl Doses. Volume 3. Habitat and Vegetation Near the Chernobyl Nuclear Reactor Station

DTIC Science & Technology

1993-01-01

AD-A260 167 A lexandria, VA 22310-3398 l,* Defense Nuclear Agency Alexandria, VA 22310-.3398 DNA-TR-92-37-V3 Chernobyl Doses, Volume 3-Habitat and...Vegetation Near the Chernobyl Nuclear Reactor Station DTIC~ ELECTF. Elizabeth L. Painter i IN•9 199EIF F. Ward Whicker JAN % 93f Pacific-Sierra...930101 Technical 870929- 920228 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS Chernobyl Doses C - DNA 001-87-C-0104 Volume 3-Habitat and Vegetation Near the

Annual Report to Congress, Fiscal Year 1997. A Report by the Scientific Advisory Board of the Strategic Environmental Research and Development Program.

DTIC Science & Technology

1998-03-01

Environmental Research June 18, 1998 Ms. Joyce Chiras Defense Technical Information Center DTIC/OCA Suite 0944 8725 John J. Kingman Road Ft. Belvoir, VA 22060...6218 Re: Strategic Environmental Research and Development Program (SERDP) Annual Reports to Congress - FY 1997 Dear Ms. Chiras : Enclosed are copies of...Achievement in Water Science and Technology, National Water Research Institute, 1996; The Gordon Maskew Fair Award, American Academy of Environmental

Resistance to Total Quality Leadership Change: An Evaluation of Individual Marine Responses to TQL Principles and Change

DTIC Science & Technology

1991-12-01

those who still have no idea what it is.[ Shoop ] This scenario makes clear the importance of understanding individuals’ fear of change and possible...Technology Index (ASTI) • Defense Technical Information Center (DTIC) " OCLC Online Union Catalog (FirstSearch) " Old "key word" database searches currently...Marine Corps to fashion the transition in such a way that it meets with the fewest objections possible. B. RECOMMENDATIONS TQL methodology itself

Laser R and D in the armed services

NASA Astrophysics Data System (ADS)

Seidel, R. W.; Bromberg, J. L.

1984-09-01

During the year, September 15, 1983 - September 15, 1984, Dr. Joan Lisa Bromberg has investigated the history of the laser through the interviewing of laser industry pioneers and leaders in California's Bay area and the Murray Hill branch of AT & T's Bell Labs. The status of processing of the interviewee's tapes is listed. During the course of the first year of our project, Dr. Robert W. Seidel has investigated the history of military laser research and development through the exploitation of the Department of Defense's Research and Development data bases, including the Research and Development Plans, Work Unit Information Summaries, and the Technical Report Abstracts of the Defense Technical Information Center; published and unpublished technical reports of military laser research and development available through DTIC and at military installations; visits to military installations and research facilities holding manuscript materials relating to history of laser research and development; and formal and informal interviews with participants in military laser R&D projects.

Technology transfer and commercialization initiatives at TRI/Austin: Resources and examples

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matzkanin, G.A.; Dingus, M.L.

1995-12-31

Located at TRI/Austin, and operated under a Department of Defense contract, is the Nondestructive Testing Information Analysis Center (NTIAC). This is a full service Information Analysis Center sponsored by the Defense Technical Information Center (DTIC), although services of NTIAC are available to other government agencies, government contractors, industry and academia. The principal objective of NTIAC is to help increase the productivity of the nation`s scientists, engineers, and technical managers involved in, or requiring, nondestructive testing by providing broad information analysis services of technical excellence. TRI/Austin is actively pursuing commercialization of several products based on results from outside funded R andmore » D programs. As a small business, TRI/Austin has limited capabilities for large scale fabrication, production, marketing or distribution. Thus, part of a successful commercialization process involves making appropriate collaboration arrangements with other organizations to augment TRI/Austin`s capabilities. Brief descriptions are given here of two recent commercialization efforts at TRI/Austin.« less

Base Structure Annex to Manpower Requirements Report for FY 1985.

DTIC Science & Technology

1984-01-01

A 04 .I S DEPARTMENT OF DEFENSE BASE STRUCTURE ANNEX Toct 00 Manpower Requirements Report for FY 1985 JANUARY 1984 DTIC ELECTE FEB 2 7 4 >~fB OFFICE...JANUARY 1984 DTIC S ELECTE FEB27 1984 Prepared by Office of the Assistant Secretary of Defense (Manpower, Installations and Logistics) D&MM_ ffA-1ENo...individuals - Intelligence and Camunications 604 Individuals - Airlift/Sealift Forces 605 tndividua~ s - Guard and Reserves 609 Individ&ls - Training

32 CFR 159.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... policies related to personnel allowed to carry weapons for self defense. 2 Available at http://www.dtic.mil... 32 National Defense 1 2011-07-01 2011-07-01 false Definitions. 159.3 Section 159.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY PRIVATE SECURITY CONTRACTORS...

32 CFR 159.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... policies related to personnel allowed to carry weapons for self defense. 2 Available at http://www.dtic.mil... 32 National Defense 1 2010-07-01 2010-07-01 false Definitions. 159.3 Section 159.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY PRIVATE SECURITY CONTRACTORS...

32 CFR 13.5 - Policies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Policies. 13.5 Section 13.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS RESPONSIBILITIES OF THE CHIEF... or the General Counsel of the Department of Defense. 1 Available at http://www.dtic.mil/whs...

32 CFR 13.5 - Policies.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Policies. 13.5 Section 13.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS RESPONSIBILITIES OF THE CHIEF... or the General Counsel of the Department of Defense. 1 Available at http://www.dtic.mil/whs...

32 CFR 13.5 - Policies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Policies. 13.5 Section 13.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS RESPONSIBILITIES OF THE CHIEF... or the General Counsel of the Department of Defense. 1 Available at http://www.dtic.mil/whs...

32 CFR 159.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... weapons for self defense. 3 Available at http://www.dtic.mil/whs/directives/corres/pdf/302041p.pdf. PSC... 32 National Defense 1 2013-07-01 2013-07-01 false Definitions. 159.3 Section 159.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY PRIVATE SECURITY CONTRACTORS...

32 CFR 159.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... weapons for self defense. 3 Available at http://www.dtic.mil/whs/directives/corres/pdf/302041p.pdf. PSC... 32 National Defense 1 2012-07-01 2012-07-01 false Definitions. 159.3 Section 159.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY PRIVATE SECURITY CONTRACTORS...

32 CFR 159.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... weapons for self defense. 3 Available at http://www.dtic.mil/whs/directives/corres/pdf/302041p.pdf. PSC... 32 National Defense 1 2014-07-01 2014-07-01 false Definitions. 159.3 Section 159.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY PRIVATE SECURITY CONTRACTORS...

Proceedings of the Annual DTIC (Defense Technical Information Center) Users Conference Held at Alexandria, Virginia on 24-26 October 1984

DTIC Science & Technology

1984-10-26

conference packet and I would urge all of you to take a hard look at it and give us your ideas about the future in which we will be working. One of...scientist or engineer goes to the fiche and or the hard copy, spends a considerable amount of time researching—up to 3 or U hours—those hard copy...34 telecommuting ," meaning people do not necessarily have to go from one place to another but all ■we need is for the information to flow from one

Safety Characteristics of Non-Lithium Battery Systems. Revision 1

DTIC Science & Technology

1986-07-01

2» 1978, p. 81. 29. Ryan, D. M., Advanced Thermal Batteries , DTIC No. AD-A085193, Defense Logistics Agency, Alexandria, VA, 1980. 31. Erbacher, J...K., Hussey, C. L., and King, L. A., Proc. Power Sources Symp. 28, 1979, p. 84, 32. Ryan, D. M., Advanced Thermal Batteries , DTIC No. AD-A125581

Department of Defense Plan to Establish Public Access to the Results of Federally Funded Research

DTIC Science & Technology

2015-02-01

journal articles , data management plans, and will track metrics on compliance and public usage. The current DTIC infrastructure will be modified to...tokens to authors who submit digitally formatted scientific data and articles . DTIC will establish compliance metrics in FY15. DoD will explore...15 10. METRICS , COMPLIANCE and EVALUATION

Assistant to the secretary of defense for nuclear and chemical and biological defense programs (ATSD(NCB)). Change 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kennedy, R.

1996-03-01

This Change 1 to DoD Directive 5134.8, dated June 8, 1994, is provided to DTIC. NOTE: In accordance with Section 904 of the DoD Authorization Act for FY 1996 (P.L. 104-106), this change redesignates the Assistant to the Secretary of Defense for Atomic Energy (ATSD(AE)) as the Assistant to the Secretary of Defense for Nuclear and Chemical and Biological Defense Programs (ATSD(NCB)).

A Baseline Description of DTIC Scientific and Technical Information Support System

DTIC Science & Technology

1986-09-01

discussed below. Operations Research And Economic Analysis Office (DTIC-LO) This organizational element is currently being staffed. Its primary planned... Analysis Centers DASIAC - Ed Martin, Dave Reitz GACIAC - Richard Bartl* MCIAC - Helen Pestel * MMIAC - Sarah Ellingsworth...Overall Organization 2-5 Office Of The Administrator And Personal Staff 2-7 Equal Employment Opportunity Manager 2-7 Information Analysis

Improving Operational Readiness through Total Quality Management

DTIC Science & Technology

1991-06-21

DTIC AD-A236 611 EL CT F NAVAL WAR COLL GE C Newport, R. I. IMPROVING OPERATIONAL READINESS THROUGH TOTAL QUALITY MANAGEMENT by Herb Westphal Defense...IMPROVING OPERATIONAL READINESS THROUGH TOTAL QUALITY MANAGEMENT (TQM) A Case Study: The Defense Mapping Agency Combat Support Center (DMACSC) initiated a...of the Defense Mapping Agency Combat Support Center’s (DMACSC) Total Quality Management (TQM) improvement methodology. This allows the reader to

PROJMNG FORTRAN: An Interactive Computer Program for Use with the Defense Management Simulation Exercise.

DTIC Science & Technology

1984-03-01

DITACODE TEAfxx. They are used interactively by PRCJNG during the game sessions. The PROJENG Instructions (Appendix F) discuss the DATABASE and DATACODE...DA.7R148 709 PROJMNG FORTRAN: AN INTERACTIVE COMPUTER PROGRAM FOR 1/4 USE WITH THE DEFENSE MANAGEMENT SIMULRTION EXERCISE(U) NAVRL POSTGRADUATE...California DTIC ELECTE Y4 194 THESISB PROJMNG FORTRAN: AN INTERACTIVE COMPUTER PROGRAM FOR USE WITH THE DEFENSE MANAGEMENT SIMULATION EXERCISE by LU

Integration of communications with the Intelligent Gateway Processor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hampel, V.E.

1986-01-01

The Intelligent Gateway Processor (IGP) software is being used to interconnect users equipped with different personal computers and ASCII terminals to mainframe machines of different make. This integration is made possible by the IGP's unique user interface and networking software. Prototype systems of the table-driven, interpreter-based IGP have been adapted to very different programmatic requirements and have demonstrated substantial increases in end-user productivity. Procedures previously requiring days can now be carried out in minutes. The IGP software has been under development by the Technology Information Systems (TIS) program at Lawrence Livermore National Laboratory (LLNL) since 1975 and is in usemore » by several federal agencies since 1983: The Air Force is prototyping applications which range from automated identification of spare parts for aircraft to office automation and the controlled storage and distribution of technical orders and engineering drawings. Other applications of the IGP are the Information Management System (IMS) for aviation statistics in the Federal Aviation Administration (FAA), the Nuclear Criticality Information System (NCIS) and a nationwide Cost Estimating System (CES) in the Department of Energy, the library automation network of the Defense Technical Information Center (DTIC), and the modernization program in the Office of the Secretary of Defense (OSD). 31 refs., 9 figs.« less

Glossary: Defense Acquisition Acronyms and Terms. Revision 2

DTIC Science & Technology

1987-07-01

Approved REPORT DOCUMENTATION PAGE OMBNo. 070-O 18 la. REPORT SECURITY CLASSIFICATION lb. RESTRICTIVE MARKINGS % unclassified 2a. SECURITY CLASSIFICATION ...WORK UNIT Fort Belvoir, VA 22060-5426 ELEMENT NO. NO. NO. ACCESSION NO. 11. TITLE (Include Security Classification ) Glossary Defense Acquisition...DISTRIBUTION/AVAILABILITY OF ABSTRACT 21 ABSTRACT SECURITY CLASSIFICATION [RUNCLASSIFIED/UNLIMITED 0 SAME AS RPT 0 DTIC USERS unclassified 22a. NAME OF

Department of Defense Corporate Information Management

DTIC Science & Technology

1991-04-01

of the Congress on the status and progress of the Corporate Information Management (CIM) initiative. The enclosed report is forwarded in response to... responsibility for implementing the corporate information management program across the Department. This includes the development and implementation of...AD-A251 456//l//lllt//l//l/m//l/.DTIC t ELECTE RjlhSJUNi 1 1992 Department of Defense E Corporate Information Management Prepared by the Assistant

32 CFR 21.330 - How are the DoDGARs published and maintained?

Code of Federal Regulations, 2011 CFR

2011-07-01

... document on the World Wide Web at http://www.dtic.mil/whs/directives. (c) A standing working group recommends revisions to the DoDGARs to the Director of Defense Research and Engineering (DDR&E). The DDR&E...

32 CFR 21.330 - How are the DoDGARs published and maintained?

Code of Federal Regulations, 2010 CFR

2010-07-01

... document on the World Wide Web at http://www.dtic.mil/whs/directives. (c) A standing working group recommends revisions to the DoDGARs to the Director of Defense Research and Engineering (DDR&E). The DDR&E...

The DTIC Review. Volume 5, Number 4. Homeland Defense

DTIC Science & Technology

2001-07-01

proliferated enormously in recent years. Approximately 19 nations currently produce cruise missiles of some type , while more than 75 countries possess them... types are deployed in 81 different countries. 14. http://www.ceip.org/programs/npp/cruise4.htm. 15. The United States Commission on National Security...MD WASHINGTON DC NATIONAL SECURITY AND INTERNATIONAL AFFAIRS DIV Biological Warfare Improved Defense Program Response Decision Tree Workshop, 29-30

Of Tanks and Toyotas: An Assessment of Japan’s Defense Industry

DTIC Science & Technology

1993-01-01

AD-A282 389 A RAND NOTE Of Tants and Toyotas An Asmamnt of Jan’s Defense Idustry Arthur Alexander DTIC S ELECTEJUL 2 6 1994 0 G 94-22886 RAND 94 7 21...RAND NOTE N3542-AF Of Tanks and Toyotas : An Assesmen of Japan’s Defense Idus"r Arthur Alexander Prepared for the United States Air Force Accesion For...Japanese dfense expenditures are modest when compared to those of NATO countries such as Italy and France, whose economies are considerably smaller than

A Model of an Integrated Air Defense System (IADS) for the TACOPS program

DTIC Science & Technology

1991-09-01

SUBJECT TERMS (Continue on reverse If necessary and Identify by block number) FIELD GROUP SUB-GROUP Integrated Air Defense System, iADS, TACOPS...needed. Selection criteria for picking a Measurement Of Effectiveness (MOE) are presented. Acceslon For I NTIS CRA&I DTIC TAB 0 Unannouticed 1 ...Justification B y ............................................... Di.,t ibiation Av.iabilily Codes Avai i:.djor Dist A- 1 THESIS DISCLAIMER The reader is cautioned

Program Manager: the Journal of the Defense Systems Management College, Volume 14, Number 3, May-June 1985.

DTIC Science & Technology

1985-06-01

Z2~1 31DTIC TAR 31 Unaflnonc.-d Successful The S N wDefense Challenge: Distribul Systems Spare Parts Availability Dr. Joniathian D. Kaplan Lieutenant...Developing Human Perform- hardware software has not been ing that the resulting design be capable ance Specifications ( Kaplan & Crooks, developed at this...design to perform at the components: MOS-characteristics specified criteria. Although the map, analysis-characteristics map, and E Dr. Kaplan is a

Directory of AFRL/HEA Technical Publications Submitted to DTIC from 1969 to 2007

DTIC Science & Technology

2007-09-01

Research Division ( AFRL /HEA) 2004 to 30 September 1007 – Air Force Research Laboratory , Warfighter Readiness Research Division ( AFRL /HEA...NUMBER 2003 AIR FORCE RESEARCH LABORATORY WARFIGHTER TRAINING RESEARCH DIVISION ( AFRL /HEA) TECHNICAL DOCUMENTS AUTHOR(S) AFRL -HE-AZ-TP-2003...NUMBER WORK UNIT NUMBER 2002 AIR FORCE RESEARCH

32 CFR 260.5 - Responsibilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Available from http://www.dtic.mil/whs/directives/corres/html/416570.htm. (5) The On-Site Official shall be... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 260.5 Section 260.5 National... VENDING FACILITY PROGRAM FOR THE BLIND ON DOD-CONTROLLED FEDERAL PROPERTY § 260.5 Responsibilities. (a...

32 CFR 108.4 - Policy.

Code of Federal Regulations, 2013 CFR

2013-07-01

... (Health Affairs/TMA FHP&RP), 1200 Defense Pentagon, Room 3E1073, Washington, DC 20301-1200. (ii) DoD...://www.dtic.mil/whs/directives/corres/pdf/302041p.pdf. (h) Emergency Health Care. The Secretaries of the Military Departments and the USD(P&R) may designate emergency patients as eligible for emergency health...

32 CFR 108.4 - Policy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (Health Affairs/TMA FHP&RP), 1200 Defense Pentagon, Room 3E1073, Washington, DC 20301-1200. (ii) DoD...://www.dtic.mil/whs/directives/corres/pdf/302041p.pdf. (h) Emergency Health Care. The Secretaries of the Military Departments and the USD(P&R) may designate emergency patients as eligible for emergency health...

32 CFR 108.4 - Policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... (Health Affairs/TMA FHP&RP), 1200 Defense Pentagon, Room 3E1073, Washington, DC 20301-1200. (ii) DoD...://www.dtic.mil/whs/directives/corres/pdf/302041p.pdf. (h) Emergency Health Care. The Secretaries of the Military Departments and the USD(P&R) may designate emergency patients as eligible for emergency health...

Department of Defense General/Flag Officer Worldwide Roster, June 1994

DTIC Science & Technology

1994-06-01

9310 930701 CHIEF OF STAFF O’NEAL JAMES P BG÷ USA 9405 900301 CG 13TH CORPS SUPPORT COMMAND-FT HOOD,TX MAHAN CHARLES S JR BG USA 9306 930801 III...16 MEADE DAVID C ................... 13 MAHAN CHARLES S JR .............. 14 MEIGS MONTGOMERY C .............. 19 MAHER JOHN J III...AD-A28 2 953 M13 Department of Defense GENERAIFLAG OFFICER WORLDWIDE ROSTER JUNE 1994 DTIC JUNE 1ELECTE~ AUG 0 8 1994 S ..• F 94-248cre 󈧏 ?’ov2 di

Ethics and National Defense: The Timeless Issues

DTIC Science & Technology

1993-02-01

that responsibility while asserting a personal morality of pacifism is simply unconscionable. 6 A personal morality of ethical egoism , even en...contained in, Personal morality, 82 18-20, 30-31,64,80,90 of enlightened egoism , 12 professional value of, 21,29 of ethical egoism , 12 246 INDEX and...ADiiV264 467 JAM •STOJANIS DTIC 93-09884 ELECTE U, rllllllllclllilllll[) FFI I ICS .\\ N D \\)..I 0 N. X . )F F: PN S F ETHICS AND NATIONAL DEFENSE THE

ESPRIT Technical Week, Information Technology Forum Day

DTIC Science & Technology

1990-06-15

Brussels, the Information Technology (IT) grams have functioned better because of the lessons Forum Day of the ESPRIT Technical Week is devoted to learned ...ONREUR Report 90_3-C 1 iLL WEIP DTIC ELECTE AUG 221990 99rU ESPRIT Technical Week, Information Technology Forum Day J.F. Blackburn I-I Lfl 15 June...Classification) ESPRIT Technical Week, Information Technology Forum Day 12 PERSONAL AUTHOR(S) J.F. Blackburn 13a TYPE or REPORT I13b TIME (.OVERED 14 DATE

Legal Services: Military Justice

DTIC Science & Technology

1999-08-20

the element generally known as “ organized crime” including both traditional ( La Cosa Nostra) and nontraditional organizations whether or not the...RESPONSIBLE PERSON internet , (blank) lfenster@dtic.mil a. REPORT Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified 19b. TELEPHONE NUMBER...will promptly notify the appropriate Department of De - fense investigative agency of the initiation of the Department of Defense related

IEEE (Institute of Electrical and Electronics Engineers) International Pulsed Power Conference on (2nd) Held in Lubbock, Texas on 12-14 June 1979 (Digest of Technical Papers)

DTIC Science & Technology

1980-02-01

PHOTOGRAPH THIS SHEET 0 FILE P.IwLEVEL IVETRY U- AFP65,f-7YA ga- - II IDS DTIBUTION T ATEMNT A App.-ove~d for public release; Di.-tribuilon Unlinitod... PHOTOGRAPH THIS SHEET AND RETURN TO DTIC-FDAC DTIC FORM 70A DOCUMENT PROCESSING SHEET PREVIOUS EDITION MAY BE USED UNTIL MAR 86 STOCK IS EXHAUSTED. IEEE 2rd...Kolm devel- transfers momencum from a massive ch..ically diven oped the "mass driver" as part of two NASA -AMES sum- armacure to a much lighter, hi h r

The Leadership Improvement Modules of the Precommissioning Leadership Assessment Program

DTIC Science & Technology

1986-02-01

Institute - Patricia Knight Davis Development Dimensions International DTIC ELECTE SEP 0 3W U5 D Leadership and Management Technical Area Manpower and... Management skills Development Management training Interpersonal skills Remedial training Leadership skills Role playing IL ASISRACT (Cl -ewi rebb emem II by...Burke Army Research Institute Patricia Knight Davis Development Dimensions International Leadership and Management Technical Area William W. Haythorn

A Microprocessor-Based Real-Time Simulator of a Turbofan Engine

DTIC Science & Technology

1988-01-01

NASA AVSCOM Technical Memorandum 100889 Technical Report 88-C-011 Lfl A Microprocessor-Based Real-Time Simulator of a Turbofan Engine CD I Jonathan S...Accession For NTIS GRA&I A MICROPROCESSOR-BASED REAL-TIME SIMULATOR DTIC TABUnannounced OF A TURBOFAN ENGINE Justifiaation, Jonathan S. Litt Propulsion...the F100 engine without augmentation (without afterburning). HYTESS is a simplified simulation written in FORTRAN of a generalized turbofan engine . To

Army Industrial Fund Rate Stabilization Program.

DTIC Science & Technology

1986-11-01

orders. Most cost reimbursable orders fall outside of the four exclusions authorized by the revised DA policy on fixed rate orders. Of the cost reimbur ... reimbursable programs. , . 20 DISTRIBUTION/AVAILABILITY OF ABSTRArT 21 ABSTRACT SECURITY CLASSIFICATION M UNCLASSIFIED/UNLIMITED 0 SAME AS RPT - DTIC USERS...customers who reimburse the fund. Industrial funds are intended to be self-sustaining. Department of Defense (DOD) policy as enumerated in DOD

U.S. Army Student Detachment Student Handbook

DTIC Science & Technology

1991-06-06

submit a thesis or do a major research project to meet graduation requirements, you must submit copies of the final product to the DTIC system to give...34 Identification Cards .......................................... 34 DEERS (Defense Eligibility Enrollment Report System ...USASD has access to a CONUS-wide telephone system . Therefore, no collect calls will be accepted. 4. If you do not have access to an AUTOVON, you may

Systems Execution Modeling Technologies for Large-Scale Net-Centric Department of Defense Systems

DTIC Science & Technology

2011-12-01

pp. 303–338, 2002. [53] K. C. Kang, “Feature-oriented domain analysis ( FODA ) feasibility study,” DTIC Document, 1990. [54] V. Kumar, “Algorithms...29  5.2  PLA MODELING, DOMAIN  ANALYSIS , AND TESTING CHALLENGES...29  5.3  MODEL‐DRIVEN TESTING AND DOMAIN  ANALYSIS  TECHNIQUES FOR PRODUCT‐LINE ARCHITECTURES ................................. 30

Goal Reconstruction: How Teton Blends Situated Action and Planned Action

DTIC Science & Technology

1989-11-03

DTIC FILE COPy 00 P 1n GOAL RECONSTRUCTION: HOW TETON BLENDS N SITUATED ACTION AND PLANNED ACTION Technical Report AIP 125 Kurt VanLehn William Ball...distribiikn unlimited. so 08 21 2 GOAL RECONSTRUCTION: HOW TETON BLENDS SITUATED ACTION AND PLANNED ACTION Technical Report AlP 125 Kurt VanLehn William Ball...Architectures for Intelligence. This is the final report on the research supported by the Computer Science Division, Office of Naval Research, under

2015 QuickCompass of Sexual Assult-Related Responders: Statistical Methodology Report

DTIC Science & Technology

2016-02-01

2015 QuickCompass of Sexual Assault Prevention and Response- Related Responders Statistical Methodology Report Additional copies of this report...from: http://www.dtic.mil/ Ask for report by ADA630235 DMDC Report No. 2015-039 February 2016 2015 QUICKCOMPASS OF SEXUAL ASSAULT PREVENTION...Defense Research, Surveys, and Statistics Center (RSSC) 4800 Mark Center Drive , Suite 04E25-01, Alexandria, VA 22350-4000 ii Acknowledgments

TRADOC Library and Information Network (TRALINET)

DTIC Science & Technology

1979-03-01

by the Library of Congress, Dewey materials that have beer photographically reduced Decimal , or any other classification scheme adopted in size for...sites at Forts Hood, TX; Gordon, GA; Monroe, VA; Knox, KY, and Leavenworth, KS. DTIC, formally Defense Documentation Center ( DDC ), serves as the primary...locally expanded subject schedules, whether schedules aic for Dewey , Library of Congress, etc., particularly in the are& of Military Arts and Sciences. 1 4

Characterization of Rain Attenuation and Depolarization at W/V Bands

DTIC Science & Technology

2015-07-30

AIR FORCE BASE , NM 87117-5776 DTIC COPY NOTICE AND SIGNATURE PAGE Using Government drawings, specifications, or other data included in this...WITH ASSIGNED DISTRIBUTION STATEMENT. //SIGNED// //SIGNED// STEVEN A. LANE PAUL HAUSGEN, Ph.D. Program Manager Technical Advisor, Space Based Advanced... Stations ........................................................................................ 11  Figure 3. Transmitter Block Diagram

STI Handbook: Guidelines for Producing, Using, and Managing Scientific and Technical Information in the Department of the Navy. A Handbook for Navy Scientists and Engineers on the Use of Scientific and Technical Information

DTIC Science & Technology

1992-02-01

6 What Information Should Be Included in the TR Database? 2-6 What Types of Media Can Be Used to Submit Information to the TR Database? 2-9 How Is...reports. Contract administration documents. Regulations. Commercially published books. WHAT TYPES OF MEDIA CAN BE USED TO SUBMIT INFORMATION TO THE TR...TOWARD DTIC’S WUIS DATA- BASE ? The WUIS database, used to control and report technical and management data, summarizes ongoing research and technology

Annotated Computer Output for Illustrative Examples of Clustering Using the Mixture Method and Two Comparable Methods from SAS.

DTIC Science & Technology

1987-06-26

BUREAU OF STANDAR-S1963-A Nw BOM -ILE COPY -. 4eo .?3sa.9"-,,A WIN* MAT HEMATICAL SCIENCES _*INSTITUTE AD-A184 687 DTICS!ELECTE ANNOTATED COMPUTER OUTPUT...intoduction to the use of mixture models in clustering. Cornell University Biometrics Unit Technical Report BU-920-M and Mathematical Sciences Institute...mixture method and two comparable methods from SAS. Cornell University Biometrics Unit Technical Report BU-921-M and Mathematical Sciences Institute

Military Knowledge Handbook for Commanders (Selected Section)

DTIC Science & Technology

1988-03-28

8217 Accession For NTIS GRA&I DTIC TAB 0l Unannoun ed 0] ju,.it . " t ation Distri’muti on/ Availabilit %Codes Dist cSpeial GRAPHICS DISCLAIMER...cloud layers, the energy of ray radiation on the ground will increase due to reflection effect of the cloud layers. Water surface, ice, accumulated... water flow can direct the radioactive fallout into defense works and water sources to worsen contaminations; radioactive fallout can easily be retained in

The Operational Level of War

DTIC Science & Technology

1985-12-01

efforts at destruction, and subsequent bridging operations in the let U.S. Army area are described. SBounds, Gary L., et al. Larger Units: Theater Army...modern commanders. Chervonobab, V. P., et al. Army Operations. Moscow: Ministry of Defense, 1977. DTIC ADB-070776L. This Soviet study contains case...maneuver and mobility. His work is of limited value today. Crittenberger, W. D., Lt. Gen., et al. "Mobility in the Field Army. Armor 60 (September-October

Jointness: A Selected Bibliography

DTIC Science & Technology

2010-12-01

2010. 113pp. (U260 .E33 2010) http://www.rand.org/pubs/monographs/2010/RAND_MG675.pdf Button, Robert , et al . Maritime Prepositioning Force (Future...SiteCollectionDocuments/ILW%20Web-ExclusivePubs/ Land%20Warfare%20Papers/LWP69.pdf Cole, Ronald H., et al . The History of the Unified Command Plan...http://handle.dtic.mil/100.2/ADA479692 Conley, Raymond E., et al . Enhancing the Performance of Senior Department of Defense Civilian Executives

The DTIC Review; Volume 3 Number 4. Antimissile Defense: Strategic Interceptor

DTIC Science & Technology

1997-12-01

threat by pursuing policies and initiatives designed to both prevent and limit this aggression. Plans to improve the interception of missiles will...to this threat by pursuing policies and initiatives designed to both prevent and limit it. Plans to improve the interception of missiles will depend...the 21st Century, it must be able to deter adversaries possessing or planning to possess WMD. If not, threats of WMD use by adversaries will prevent

STARS Conceptual Framework for Reuse Process (CFRP). Volume 1. Definition. Version 3.0

DTIC Science & Technology

1993-10-25

Command, USAF Hanscom AFB, MA 01731-5000 DTIC QUALITY IN ,,P.’±U4) D Prepared by: The Boeing Company , IBM, Defense & Space Group, Federal Systems... Company , Unisys Corporation, P.O. Box 3999, MS 87-37 800 N. Frederick Pike, 12010 Sunrise Valley Drive, Seattle, WA 98124-2499 Gaithersburg, MD 20879...34 3.2.1.1 Domain Analysis and Modeling Process Category ............ 38 3.2.1.2 Domain Architecture Development Process

The Shock and Vibration Bulletin. Part 1. Welcome, Keynote Adddress, Invited Papers, Isolation and Damping and Damping Practices

DTIC Science & Technology

1985-06-01

HPFTP Blade Airfoil 1984. Mass VS Frequency of Excitation 5 . R.J. Dominic, "Turbine Blade Damping Study," University of ACHNOWLEDGEMENT Dayton Research ...Damping Practices JUNE 1985 A Publication of TH-E SHOCK ANI) VIBRATION INFORMATION CENTER Naval Research Laboratory, Washington, I).C.- DTIC OCT 1686...Office ofE The Under Secretary of Defense for Research and Engineering Approved for public release; distribution unlimited. 85 10 15 027

Identification and Mapping of Mechanically Exfoliated 1H-MoS2 Flakes for Field-Effect Transistors

DTIC Science & Technology

2014-08-01

structures directly onto 1H- and 2H-MoS2. A methyl methacrylate (MMA) and polymethyl methacrylate ( PMMA ) bilayer resist process will be used for all...the fiscal year. 9 5. References 1. Novoselov KS, Geim AK, Morozov SV, Jiang D, Zhang Y, Dubonos SV, Grigorieva IV, Firsov AA . Electric...photoluminescence PMMA polymethyl methacrylate TMDs transition metal dichalcogenides 12 1 DEFENSE TECH INFO CTR (PDF) ATTN DTIC OCA (PDF) 2

Computer-Aided System Needs for the Technical Design Section of the Base Level Civil Engineering Squadron.

DTIC Science & Technology

1986-09-01

iUADROi THESIS James P. ’Mi’tnik First Lieutenant, USAF AFIT/GEM/DEM/86S-1 9 Approved for public release; distribution unlimited DTIC F--I F CT ESDEC 16...9 COMPUTER-AIDED SYSTEM NEEDS FOR THE TECHNICAL DESIGN SECTION OF THE BASE LEVEL CIVIL ENGINEERING SQUADRON THESIS V :-. . Presented to the Faculty...directed his own thesis and then turned around as an AFIT instructor, and helped direct mine. His suggestions, talk and ability to calm me down

Toward a Theory of Representation Design

DTIC Science & Technology

1989-05-01

understanding. This report describes research done at the Artificial Inteligence Laboratory of the Massachusetts Institute of Technology. Support for this...AD-A210 885 Technical Report 1128 Toward a Theory of Representation Design Jeffrey Van Baale MIT Artificial Intelligence Laboratory DTIC ELECTE A... Artificial Intelligence Laboratory 545 Technology Square Cambridge, MA 02139 11. CONTROLLING OFFICE NAME AND ADDRESS 11. REPORT DATE Advanced Research

Comparison of a treatment strategy combining CCI-779 plus DTIC versus DTIC monotreatment in human melanoma in SCID mice.

PubMed

Thallinger, Christiane; Werzowa, Johannes; Poeppl, Wolfgang; Kovar, Florian M; Pratscher, Barbara; Valent, Peter; Quehenberger, Peter; Joukhadar, Christian

2007-10-01

This study compares the antineoplastic potential of a novel treatment strategy combining cell cycle inhibitor-779 (CCI-779) plus dacarbazine (DTIC) versus DTIC monotreatment, the current chemotherapeutic mainstay in combating metastatic melanoma. A controlled four-group parallel study design comprising 24-40 mice per tumor cell line was used in a severe combined immunodeficiency (SCID)-mouse xenotransplantation model. SCID mice were injected with 518A2, Mel-JUSO, or 607B human melanoma cells. After they developed tumors, mice received daily CCI-779 or solvent over 14 days. From treatment day 4-8 mice were additionally injected with DTIC or saline. Treatment with CCI-779 plus DTIC was superior to single agent DTIC in two out of three cell lines (P<0.05). The tumor weight reduction was 44+/-17 and 61+/-6% compared with DTIC monotreatment in Mel-JUSO and 607B melanomas, respectively (P<0.05). In contrast, in 518A2 xenotransplants, CCI-779 plus DTIC treatment was as effective as DTIC monotreatment. CCI-779 monotherapy exerted no statistically significant antitumor effect. Collectively, these data indicate that CCI-779 has the potential to increase the chemotherapeutic efficacy, as the combination of CCI-779 plus DTIC proved to be more efficacious compared to DTIC monotherapy in two out of three melanoma cell lines in vivo.

Iran’s Nuclear Future: Critical U.S. Policy Choices

DTIC Science & Technology

2011-01-01

embargo as an act of war, and it could respond by attempting to close the Strait of Hormuz, using mines , antiship cruise missiles, or fast patrol boats...even it means we have to compromise on sovereignty by having U.S. troops deployed here” (quoted in Barbara Opall -Rome, “U.S. to Deploy Radar, Troops...2009. As of January 13, 2011: http://handle.dtic.mil/100.2/ADA510110 Opall -Rome, Barbara, “U.S. to Deploy Radar, Troops in Israel,” Defense News, August

Agent-Based Modeling and Simulation: Proposal for Department of Defense Support to the Whole of Government Approach In Afghanistan

DTIC Science & Technology

2012-05-11

September 1, 2011). 5 Abraham Maslow , Motivation and Personality, Third Edition, Harper and Row Publishers, 1954, 91-236. 6 Joshua M. Epstein, “Why...Response Program." Joint Force Quarterly, no. 37 (2005): 46, http://www.dtic.mil/doctrine/jel/jfq_pubs/0937.pdf (accessed October 15, 2011). Maslow ... Abraham . Motivation and Personality. Third ed. New York, New York: Harper and Row, 1954. Mattis, James. US Central Command Commander’s Posture

Successes in the Small Business Innovative Research Program

DTIC Science & Technology

1989-03-01

SUCCESSES IN THE SMALL BUSINESS INNOVATIVE RESEARCH PROGRAM IC Report PL806R1 4. , March 1989 Aooession For I NTIS GRA&I DTIC TAB Unannounced 13 Just...pursuant to Department of Defense Contract MDA903-85-C-0139. The views expressed here are those of the Logistics Management Institute at the time of issue...obtained f om the Logistics Management Ins itute. F L TF LOGISTICS MANAGEMENT INSTITUTE S 1 Y0? 6400 Goldsboro Road Bethesda, Maryland 20817-5886 r0w89 5

Report of the Defense Science Board 1981 Summer Study Panel on Operational Readiness with High Performance Systems

DTIC Science & Technology

1982-04-01

Research and Engineering Colonel Francis D. Bettinger , USA Deputy Director, Soldier Support Center, National Capitol Region Major Andrew A . Gorman...WASHINGTON, D.C. NTIS GRA&I DTIC TABj Urlka ounced [] A 3Lstifi"•°to - APRIL 1982 COPY Distribution/__ Availability Codes Avail and/or 4o...SDSTRIBUTION STATEMENT A Appioved fox public teeoazel . Distribution Unlimited OFFICE OF THE SECRETARY OF Dm_..g TI- OFFICE Or WASHINGTON, D.C. Z0301 £ . 13

Machine aided indexing from natural language text

NASA Technical Reports Server (NTRS)

Silvester, June P.; Genuardi, Michael T.; Klingbiel, Paul H.

1993-01-01

The NASA Lexical Dictionary (NLD) Machine Aided Indexing (MAI) system was designed to (1) reuse the indexing of the Defense Technical Information Center (DTIC); (2) reuse the indexing of the Department of Energy (DOE); and (3) reduce the time required for original indexing. This was done by automatically generating appropriate NASA thesaurus terms from either the other agency's index terms, or, for original indexing, from document titles and abstracts. The NASA STI Program staff devised two different ways to generate thesaurus terms from text. The first group of programs identified noun phrases by a parsing method that allowed for conjunctions and certain prepositions, on the assumption that indexable concepts are found in such phrases. Results were not always satisfactory, and it was noted that indexable concepts often occurred outside of noun phrases. The first method also proved to be too slow for the ultimate goal of interactive (online) MAI. The second group of programs used the knowledge base (KB), word proximity, and frequency of word and phrase occurrence to identify indexable concepts. Both methods are described and illustrated. Online MAI has been achieved, as well as several spinoff benefits, which are also described.

Multistep Methods for Integrating the Solar System

DTIC Science & Technology

1988-07-01

Technical Report 1055 [Multistep Methods for Integrating the Solar System 0 Panayotis A. Skordos’ MIT Artificial Intelligence Laboratory DTIC S D g8...RMA ELEENT. PROECT. TASK Artific ial Inteligence Laboratory ARE1A G WORK UNIT NUMBERS 545 Technology Square Cambridge, MA 02139 IL. CONTROLLING...describes research done at the Artificial Intelligence Laboratory of the Massachusetts Institute of Technology, supported by the Advanced Research Projects

A Distributed User Information System

DTIC Science & Technology

1990-03-01

NOE08 Department of Computer Science NOVO 8 1990 University of Maryland S College Park, MD 20742 D Abstract Current user information database technology ...Transactions on Computer Systems, May 1988. [So189] K. Sollins. A plan for internet directory services. Technical report, DDN Network Information Center...2424 A Distributed User Information System DTiC Steven D. Miller, Scott Carson, and Leo Mark DELECTE Institute for Advanced Computer Studies and

JPRS Report, Science & Technology, USSR: Computers.

DTIC Science & Technology

1988-07-08

Computers DISTRIBUTION STAfpiEFTX Approved !CJ- public vekrase; Distribution Unla;u;ed DTIC QUALITY INSPECTED S REPRODUCED BY U.S. DEPARTMENT OF...COMMERCE National Technical Information Service SPRINGFIELD, VA. 22161 /O o f\\H JPRS-UCC-88-002 8 JULY 1988 SCIENCE & TECHNOLOGY USSR: COMPUTERS ...CONTENTS GENERAL Computers : Steps to the World Level ,nm^VA „ 17Q (V. Kovalenko; SOTSIAL1STICIIESKAYA INDUSTRIYA, No 178, 4 Aug 87

Solar Observations on Magneto-Convection

DTIC Science & Technology

1989-05-31

Technical Library National Solar Observatory Sunspot, NM 88349 Karl - Schwarzschild -Strasse 1 8046 Garching bei Mundhen Solar Observations On Magneto...Schmidt, Hermann-Ulrich Schmidt, Hans-Christoph Thomas (eds.) Max-Planck-Institut fir Physik und Astrophysik Institut fiur Astrophysik Karl ... Schwarzschild -St-. 1 D-8046 Garching, FklG 14TIS CRiA.&l DTIC TA. U~Jar,iou8:ed B ......... ... Distribution I -- Availability COcý----- Avail and or Dist special

78 FR 41331 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 225 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is making technical amendment to the Defense...

DR5 mAb-conjugated, DTIC-loaded immuno-nanoparticles effectively and specifically kill malignant melanoma cells in vivo.

PubMed

Ding, Baoyue; Zhang, Wei; Wu, Xin; Wang, Jeffrey; Xie, Chen; Huang, Xuan; Zhan, Shuyu; Zheng, Yongxia; Huang, Yueyan; Xu, Ningyin; Ding, Xueying; Gao, Shen

2016-08-30

We combined chemo- and immunotherapies by constructing dual therapeutic function immuno-nanoparticles (NPs) consisting of death receptor 5 monoclonal antibody (DR5 mAb)-conjugated nanoparticles loaded with dacarbazine (DTIC) (DTIC-NPs-DR5 mAb). We determined the in vivo targeting specificity of DTIC-NPs-DR5 mAb by evaluating distribution in tumor-bearing nude mice using a real-time imaging system. Therapeutic efficacy was assessed in terms of its effect on tumor volume, survival time, histomorphology, microvessel density (MVD), and apoptotic index (AI). Systemic toxicity was evaluated by measuring white blood cells (WBC) counts, alanine aminotransferase (ALT) levels, and creatinine clearance (CR).In vivo and ex vivo imaging indicates that DR5 mAb modification enhanced the accumulation of NPs within the xenograft tumor. DTIC-NPs-DR5 mAb inhibited tumor growth more effectively than DTIC or DR5 mAb alone, indicating that combining DTIC and DR5 mAb through pharmaceutical engineering achieves a better therapeutic effect. Moreover, the toxicity of DTIC-NPs-DR5 mAb was much lower than that of DTIC, implying that DR5 mAb targeting reduces nonspecific uptake of DTIC into normal tissue and thus decreases toxic side effects. These results demonstrate that DTIC-NPs-DR5 mAb is a safe and effective nanoparticle formulation with the potential to improve the efficacy and specificity of melanoma treatment.

Phase II study of second-line therapy with DTIC, BCNU, cisplatin and tamoxifen (Dartmouth regimen) chemotherapy in patients with malignant melanoma previously treated with dacarbazine.

PubMed

Propper, D J; Braybrooke, J P; Levitt, N C; O'Byrne, K; Christodoulos, K; Han, C; Talbot, D C; Ganesan, T S; Harris, A L

2000-06-01

This study assessed response rates to combination dacarbazine (DTIC), BCNU (carmustine), cisplatin and tamoxifen (DBPT) chemotherapy in patients with progressive metastatic melanoma previously treated with DTIC, as an evaluation of DBPT as a second-line regimen, and as an indirect comparison of DBPT with DTIC. Thirty-five consecutive patients received DBPT. The patients were divided into two groups. Group 1 comprised 17 patients with progressive disease (PD) on DTIC + tamoxifen therapy who were switched directly to DBPT. Group 2 comprised 18 patients not immediately switched to DBPT and included patients who had either a partial response (PR; one patient) or developed stable disease (SD; four patients) with DTIC, or received adjuvant DTIC (nine patients). All except four patients had received tamoxifen at the time of initial DTIC treatment. Median times since stopping DTIC were 22 days (range 20-41) and 285 days (range 50-1,240) in Groups 1 and 2 respectively. In Group 1, one patient developed SD for 5 months and the remainder had PD. In Group 2, there were two PRs, four patients with SD (4, 5, 6, and 6 months), and 11 with PD. These results indicate that the DBPT regimen is not of value in melanoma primarily refractory to DTIC. There were responses in patients not directly switched from DTIC to DBPT, suggesting combination therapy may be of value in a small subgroup of melanoma patients.

DR5 mAb-conjugated, DTIC-loaded immuno-nanoparticles effectively and specifically kill malignant melanoma cells in vivo

PubMed Central

Wang, Jeffrey; Xie, Chen; Huang, Xuan; Zhan, Shuyu; Zheng, Yongxia; Huang, Yueyan; Xu, Ningyin; Ding, Xueying; Gao, Shen

2016-01-01

We combined chemo- and immunotherapies by constructing dual therapeutic function immuno-nanoparticles (NPs) consisting of death receptor 5 monoclonal antibody (DR5 mAb)-conjugated nanoparticles loaded with dacarbazine (DTIC) (DTIC-NPs-DR5 mAb). We determined the in vivo targeting specificity of DTIC-NPs-DR5 mAb by evaluating distribution in tumor-bearing nude mice using a real-time imaging system. Therapeutic efficacy was assessed in terms of its effect on tumor volume, survival time, histomorphology, microvessel density (MVD), and apoptotic index (AI). Systemic toxicity was evaluated by measuring white blood cells (WBC) counts, alanine aminotransferase (ALT) levels, and creatinine clearance (CR).In vivo and ex vivo imaging indicates that DR5 mAb modification enhanced the accumulation of NPs within the xenograft tumor. DTIC-NPs-DR5 mAb inhibited tumor growth more effectively than DTIC or DR5 mAb alone, indicating that combining DTIC and DR5 mAb through pharmaceutical engineering achieves a better therapeutic effect. Moreover, the toxicity of DTIC-NPs-DR5 mAb was much lower than that of DTIC, implying that DR5 mAb targeting reduces nonspecific uptake of DTIC into normal tissue and thus decreases toxic side effects. These results demonstrate that DTIC-NPs-DR5 mAb is a safe and effective nanoparticle formulation with the potential to improve the efficacy and specificity of melanoma treatment. PMID:27494835

Dacarbazine-Loaded Hollow Mesoporous Silica Nanoparticles Grafted with Folic Acid for Enhancing Antimetastatic Melanoma Response.

PubMed

Liu, Qianqian; Xu, Nan; Liu, Liping; Li, Jun; Zhang, Yamin; Shen, Chen; Shezad, Khurram; Zhang, Lianbin; Zhu, Jintao; Tao, Juan

2017-07-05

Dacarbazine (DTIC) is one of the most important chemotherapeutic agents for the treatment of melanoma; however, its poor solubility, photosensitivity, instability, and serious toxicity to normal cells limit its clinical applications. In this article, we present a rationally designed nanocarrier based on hollow mesoporous silica nanoparticles (HMSNs) for the encapsulation and targeted release of DTIC for eradicating melanoma. The nanocarrier (DTIC@HMLBFs) is prepared by modifying HMSNs with carboxyl groups to enhance the loading of DTIC, followed by further enveloping of folic acid-grafted liposomes, which act as a melanoma active target for controlled and targeted drug release. In vitro, DTIC@HMLBFs exhibited the strongest cytotoxicity to melanoma cells compared with DTIC@HMSNs and free DTIC. The in vivo investigations demonstrate that the rationally designed nanocarrier loaded with DTIC achieves significant improvement against lung metastasis of melanoma via targeting melanoma cells and tumor-associated macrophages. This study provides a promising platform for the design and fabrication of multifunctional nanomedicines, which are potentially useful for the treatment of melanoma.

OPERATION CASTLE. Radiological Safety. Volume 1

DTIC Science & Technology

1985-09-01

OPERATION CASTLE Radiological Safety Final Report Volume I Headquarters Joint Task Force Seven Technical Branch, J-3 Division Washington, DC...Spring 1954 EXTRACTED VERSION DTIC -uECTE MAR031986 NOTICE: This is an extract of Operation CASTLE, Radiological Safety, Final Report, Volume I ...SYMBOL (If jpQiictbl») ■ i PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER 8c AOORESS (G(y, SU(t tncl ZIRCod») 10 SOURCE OF FUNDING NUMBERS PROGRAM

Spreadsheet-Like Image Analysis

DTIC Science & Technology

1992-08-01

1 " DTIC AD-A254 395 S LECTE D, ° AD-E402 350 Technical Report ARPAD-TR-92002 SPREADSHEET-LIKE IMAGE ANALYSIS Paul Willson August 1992 U.S. ARMY...August 1992 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS SPREADSHEET-LIKE IMAGE ANALYSIS 6. AUTHOR(S) Paul Willson 7. PERFORMING ORGANIZATION NAME(S) AND...14. SUBJECT TERMS 15. NUMBER OF PAGES Image analysis , nondestructive inspection, spreadsheet, Macintosh software, 14 neural network, signal processing

Measuring the Readability of Training Materials by the PLATO IV Computer-Based Instructional System,

DTIC Science & Technology

1974-09-15

Technical Information Center ATTN: DTIC-DDAB P83-0290 Cameron Sta BG 5 Alexandria VA 22314 1. I regret that it took so long to respond to your request...8217- ConeokeO -; ’ the~r grade .,evec tl"-a wr, er3 5:~ng -not e *QLrisse. TV- -are :~n. - ~-t-r ecked bv~ nine educatiorwtrainine 5ptCiaiist- using Vi

Reconfigurable C2 DDP System

DTIC Science & Technology

1988-07-01

should be easily provided if the service requests can be handled simultaneously. 2.3.2 Internal Structure of Subsystems The internal structure of...Public Affairs Division (PA) and is releasable to the National Technical Information Service (NTIS). At NTIS it will be releasable to the general public...nmua n m n Imm I DISCLAIMER NOTICE THIS DOCUMENT IS BEST QUALITY PRACTICABLE. THE COPY FURNISHED TO DTIC CONTAINED A SIGNIFICANT NUMBER OF PAGES WHICH DO

Psychological Analyses of Courageous Performance in Military Personnel

DTIC Science & Technology

1990-08-01

British Columbia ARI Scientific Coordination Office, London Milton Katz, Chief Office of Basic Research Michael Kaplan , Director OTIC August1990 ELECTE...For NTIS Ri University of British Columbia DTic TAB Just fitIcat lo Technical review by Dy __Dttibut ton/ Michael Kaplan Avallability CodesDIst...22c. OFFICE SYMBOL Michael Kaplan (202) 274-8722 PERT-BR DD Form 1473, JUN 86 Previous editions are obsolete. SECURITY CLASSIFICATION OF THIS PAGE

Phase II study of second-line therapy with DTIC, BCNU, cisplatin and tamoxifen (Dartmouth regimen) chemotherapy in patients with malignant melanoma previously treated with dacarbazine

PubMed Central

Propper, D J; Braybrooke, J P; Levitt, N C; O'Byrne, K; Christodoulos, K; Han, C; Talbot, D C; Ganesan, T S; Harris, A L

2000-01-01

This study assessed response rates to combination dacarbazine (DTIC), BCNU (carmustine), cisplatin and tamoxifen (DBPT) chemotherapy in patients with progressive metastatic melanoma previously treated with DTIC, as an evaluation of DBPT as a second-line regimen, and as an indirect comparison of DBPT with DTIC. Thirty-five consecutive patients received DBPT. The patients were divided into two groups. Group 1 comprised 17 patients with progressive disease (PD) on DTIC + tamoxifen therapy who were switched directly to DBPT. Group 2 comprised 18 patients not immediately switched to DBPT and included patients who had either a partial response (PR; one patient) or developed stable disease (SD; four patients) with DTIC, or received adjuvant DTIC (nine patients). All except four patients had received tamoxifen at the time of initial DTIC treatment. Median times since stopping DTIC were 22 days (range 20–41) and 285 days (range 50–1240) in Groups 1 and 2 respectively. In Group 1, one patient developed SD for 5 months and the remainder had PD. In Group 2, there were two PRs, four patients with SD (4, 5, 6, and 6 months), and 11 with PD. These results indicate that the DBPT regimen is not of value in melanoma primarily refractory to DTIC. There were responses in patients not directly switched from DTIC to DBPT, suggesting combination therapy may be of value in a small subgroup of melanoma patients. © 2000 Cancer Research Campaign PMID:10839287

DDN (Defense Data Network) New User Guide

DTIC Science & Technology

1987-11-01

0 -944604-00- 5 ,X UNIX is a registered trademark of AT&T Bell Laboratories...21 S 0 0 N S MR A 0w l.a. . ,d. s:’V * ,t*. P.. 0 64 INDEX Access Code 14, 24 Host computer 5 , 6 Acoustic coupler 18 Hostname 16 AMC 50 ARPANET...groups. U DTIC0 0 I NI ’u1ld 1A LJ ; .:r .: ,c d - J•,:: •’: ,, ,:.3 . I1..... .. < , • .. _’’ "LY"_."_,...! ( • ••: •,a•.. -•.¢."....

Ada Implementation Guide. Software Engineering With Ada. Volume 1

DTIC Science & Technology

1994-04-01

Staff, Department ofDefense Dictionary of Military and Associated Terms, Washington, D.C., 1989. STARS McDonal , C., and S . Redwine, *STARS Glossary: A...ADýA28 357> offj I Volume I I SI I t Ada Implementation II Guide 5 Software Engineering With AdaI I S DTIC QUALITY INSPECTED S 5 April 1994 g " 94...and Abbreviations ...................... I I N p a S I I I i I Libt of F4g u OW Tahl Figures 2-1 DON Directives and Instructions for Implementing Public

An Airfield Too Far, the Army’s Search for a Runway

DTIC Science & Technology

1990-05-01

just to keep the war going. Pilots flew to the point of e>ý.austion--often nine to ten hours a day witho.t leaving their cockpits. If the British...ground controlled. approach radar (GCA) of post-World War II vintage, However, it does not have a radiation signature as a threat air defense radar. Using...AD-A241 034 zx.R WARL COLLEGE RESEARCH REPORT AN AIRFIELD TOO FAR, THE ARMY’S 5EARCH FOR A RUNWAY DTIC, LIEU.TENANT COLO-NEL KENT V. H~JFFORD, USA

An Evaluation of Potential Countermeasures to the Strategic Defense Initiative.

DTIC Science & Technology

1986-03-01

96 UNCLASSIFIED F/S 07/4 N mhmhhhhhm 111IL2 1 32P. 12.2 MICRnrCOP’ CHART % * V @ 0- * NAVAL POSTGRADUATE SCHOOL Monterey, California DTIC L -fCTE.1 E...CLASSIFICATION OF THIS PAGE All other editions are obsolete U,.. 1. l .... .%.** .. . . . .. .... . . . . v- I-i -AN-~- M-%--w-W Approved for public release...RESEARCH from the NAVAL POSTGRADUATE SCHOOL L March 1986 Author: - /7 DuaneM abt J. wyma(Thss Advisor A. W s b r , C a rman, ...D* Lpartment of Optin

78 FR 11947 - 60-Day Notice of Proposed Information Collection: Directorate of Defense Trade Controls...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-20

...: Directorate of Defense Trade Controls Information Collection: Export Declaration of Defense Technical Data or... . SUPPLEMENTARY INFORMATION: Title of Information Collection: Export Declaration of Defense Technical Data or... collection: Actual export of defense technical data and defense services must be reported directly to the...

Chemotherapy of Malignant Melanoma with Dimethyl Triazeno Imidazole Carboxamide (DTIC) and Nitrosourea Derivatives (BCNU, CCNU)

PubMed Central

Hill, George J.; Ruess, Robert; Berris, Robert; Philpott, Gordon W.; Parkin, Priscilla

1974-01-01

Chemotherapy for metastatic melanoma was performed in 80 consecutive evaluable patients. DTIC, BCNU and CCNU produced responses in 28% of patients, alone or in combination with each other. Three of 62 patients treated with DTIC remain free of tumor, off therapy at 18-36 months following objective regression of metastases. Chemotherapy with commercially available drugs continued to be uniformly unsuccessful. DTIC was used successfully in treatment of extensive extracranial disease, including one patient with metastatic melanoma during pregnancy. Cerebral metastases were the sole or major cause of death in 8/9 patients who relapsed following control with DTIC for nine months or longer, and one patient developed a carcinoma of the breast following therapy with DTIC and BCNU. Remission was induced in two patients with intralesional BCG, after prior attempts to control metastases with DTIC and combination chemotherapy. ImagesFig. 2.Fig. 2b.Fig. 2c. PMID:4601984

Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth.

PubMed

Hervieu, Alice; Rébé, Cédric; Végran, Frédérique; Chalmin, Fanny; Bruchard, Mélanie; Vabres, Pierre; Apetoh, Lionel; Ghiringhelli, François; Mignot, Grégoire

2013-02-01

Dacarbazine (DTIC) is a cytotoxic drug widely used for melanoma treatment. However, the putative contribution of anticancer immune responses in the efficacy of DTIC has not been evaluated. By testing how DTIC affects host immune responses to cancer in a mouse model of melanoma, we unexpectedly found that both natural killer (NK) and CD8(+) T cells were indispensable for DTIC therapeutic effect. Although DTIC did not directly affect immune cells, it triggered the upregulation of NKG2D ligands on tumor cells, leading to NK cell activation and IFNγ secretion in mice and humans. NK cell-derived IFNγ subsequently favored upregulation of major histocompatibility complex class I molecules on tumor cells, rendering them sensitive to cytotoxic CD8(+) T cells. Accordingly, DTIC markedly enhanced cytotoxic T lymphocyte antigen 4 inhibition efficacy in vivo in an NK-dependent manner. These results underscore the immunogenic properties of DTIC and provide a rationale to combine DTIC with immunotherapeutic agents that relieve immunosuppression in vivo.

Evaluation of protective effect of amifostine on dacarbazine induced genotoxicity.

PubMed

Etebari, M; Jafarian-Dehkordi, A; Lame, V

2015-01-01

Anticancer therapy with alkylating agents has been used for many years. Dacarbazine (DTIC) as an alkylating agent is used alone or in combination with other chemotherapy drugs. In order to inhibit the formation of secondary cancers resulting from chemotherapy with DTIC, preventional strategies is necessary. The present study was undertaken to evaluate the genoprotective effect of amifostine on the genotoxic effects of DTIC in cell culture condition. To determine the optimum genotoxic concentration of DTIC, HepG2 cells were incubated with various DTIC concentrations including 5, 10 and 20 μg/ml for 2 h and the genotoxic effects were evaluated by the comet assay. The result of this part of the study showed that incubation of HepG2 cells with DTIC at 5 μg/ml was sufficient to produce genotoxic effect. In order to determine the protective effects of amifostine on genotoxicity induced by DTIC, HepG2 cells were incubated with different concentrations of amifostine (2, 3 and 5 mg/ml) for 1 h which was followed by incubation with DTIC at 5 μg/ml for 2 h. One hour incubation of cells with different concentrations of amifostine before incubation with DITC indicated that at least 5 mg/ml concentration of amifostine can prevent genotoxic effects induced by DTIC on HepG2 cells under described condition. In conclusion amifostine could prevent DNA damage induced by DTIC on HepG2 cells.

Prospective randomized comparison of dacarbazine (DTIC) versus DTIC plus interferon-alpha (IFN-alpha) in metastatic melanoma.

PubMed

Young, A M; Marsden, J; Goodman, A; Burton, A; Dunn, J A

2001-01-01

Dacarbazine (DTIC) has been the mainstay of chemotherapy for metastatic melanoma for over two decades, but only 15%-20% of patients respond and benefit is usually transient. Randomized studies combining DTIC with interferon-alpha (IFN-alpha) in advanced disease have so far been inconclusive in terms of response and survival. We report a randomized prospective pilot Phase III trial of DTIC +IFN-alpha in patients with metastatic melanoma. The primary endpoint was death. A total of 61 patients were randomized between April 1995 and April 1998. Differences in survival between groups were assessed using log-rank analysis. Quality of life was measured using the European Organization for Research on Treatment of Cancer QLQ C30 (+3) questionnaire. Fifty-seven patients died during the study. The median survival for patients receiving DTIC was 7.2 months (95% confidence interval (CI) 4.4-9.0); it was 4.8 months for DTIC + IFN-alpha (95% CI 2.0-8.0). There was no significant difference in survival between the two treatment arms (chi2 unadjusted = 0.15, P = 0.70; chi2 adjusted = 0.01, P = 0.91). The 6-month survival of those patients randomized to DTIC alone was 58% compared with 40% for those patients randomized to DTIC + IFN-alpha. There were no differences in quality of life between treatment groups. This study failed to demonstrate a survival benefit for patients receiving IFN-alpha in combination with DTIC. These results are inconclusive primarily owing to the small size of the trial. A meta-analysis is required to determine whether there is a role for the addition of IFN-alpha to DTIC in the treatment of this disease.

Randomized phase II study comparing gemcitabine plus dacarbazine versus dacarbazine alone in patients with previously treated soft tissue sarcoma: a Spanish Group for Research on Sarcomas study.

PubMed

García-Del-Muro, Xavier; López-Pousa, Antonio; Maurel, Joan; Martín, Javier; Martínez-Trufero, Javier; Casado, Antonio; Gómez-España, Auxiliadora; Fra, Joaquín; Cruz, Josefina; Poveda, Andrés; Meana, Andrés; Pericay, Carlos; Cubedo, Ricardo; Rubió, Jordi; De Juan, Ana; Laínez, Nuria; Carrasco, Juan Antonio; de Andrés, Raquel; Buesa, José M

2011-06-20

To assess the activity and toxicity of the combination of gemcitabine plus dacarbazine (DTIC) in patients with advanced soft tissue sarcoma (STS) in a randomized, multicenter, phase II study using DTIC alone as a control arm. Patients with previously treated advanced STS were randomly assigned to receive either fixed-dose rate gemcitabine (10 mg/m2/min) at 1800 mg/m2 followed by DTIC at 500 mg/m2 every 2 weeks, or DTIC alone at 1200 mg/m2 every 3 weeks. The primary end point of the study was progression-free rate (PFR) at 3 months. From November 2005 to September 2008, 113 patients were included. PFR at 3 months was 56% for gemcitabine plus DTIC versus 37% for DTIC alone (P = .001). Median progression-free survival was 4.2 months versus 2 months (hazard ratio [HR], 0.58; 95% CI, 0.39 to 0.86; P = .005), and median overall survival was 16.8 months versus 8.2 months (HR, 0.56; 95% CI, 0.36 to 0.90; P = .014); both favored the arm of gemcitabine plus DTIC. Gemcitabine plus DTIC was also associated with a higher objective response or higher stable disease rate than was DTIC alone (49% v 25%; P = .009). Severe toxicities were uncommon, and treatment discontinuation for toxicity was rare. Granulocytopenia was the more common serious adverse event, but febrile neutropenia was uncommon. Asthenia, emesis, and stomatitis were the most frequent nonhematologic effects. The combination of gemcitabine and DTIC is active and well tolerated in patients with STS, providing in this phase II randomized trial superior progression-free survival and overall survival than DTIC alone. This regimen constitutes a valuable therapeutic alternative for these patients.

Training for Retrieval of Knowledge under Stress through Algorithmic Decomposition

DTIC Science & Technology

1986-10-01

Light Bulb and Dyslexia problems used by Lichtenstein & MacGregor (1985). The problems are presented in Appendix D. All aspects of the problems were...this bulb as defective. What is the orobabilitv that this bulb is really defective? The Dyslaxia Problem Dyslexia iu a disorder characterized by an...Department of the Army * Calspan Corporation Technical review by Steve Kronheim and will be available only through DTIC or other reference service& such as

Goal Reconstruction: How Teton Blends Situated Action and Planned Action

DTIC Science & Technology

1989-11-03

DTIC FILE COPY CV), Goal reconstruction: How Teton blends N situated action and planned action N Tec~jcal Report PCG- 16 Kurt VanLehn I William Bali...situated action and planned action Technical Report PCG- 16 Kurt VanLehn William Bail Departments of Psychology and Computer Science Carnegie-Mellon...Research, under contract N00014-88-K-0086 and by the Information Sciences Division, Office of Naval Research, under contract N00014-K-0678

Development of High Efficiency, Stacked Multiple Bandgap Solar Cells.

DTIC Science & Technology

1982-09-01

1982 CL APPROVED FOR PUBLIC RELEASE; DISTRIBUION UNLIMITED LAJ DTIC A12o 201sION UCIA0.TORT ELECTE A=R 7ORM VUGM AZUOUUICM LMMORRIS iv IIGRH-PATTSON...connection with a definitely related Government procurement operation, the United States Government thereby incurs no responsibility nor any obligation... Public Affairs (ASD/PA) and is releasable to the National Technical Information Service (NTIS). At NTIS, it will be available to the general public

Improving the Selection Classification, and Utilization of Army Enlisted Personnel. Supplement

DTIC Science & Technology

1988-05-01

Consumer Research, 5, 103-123. Jain, Arun K ., Acito, Franklin, Malhotra , Naresh , and Mahajan, Vijay (1978). A comparison of predictive validity of...Technical Area Lawrence M. Hanser, Chief MANPOWER AND PERSONNEL RESEARCH LABORATORY Newell K . Eaton, Director DTIC "p S "LIEC T E .,J. JUN 221988 U. S. Army...8217 , w .. CONTENTS Page ’ Utility Estimation in Five Enlisted Occupations. . . . . . . . . . . . . Newell K . Eaton, Hilda Wing, and Alan Lau (ARI

Automatic Line Network Extraction from Aerial Imagery of Urban Areas through Knowledge Based Image Analysis

DTIC Science & Technology

1989-08-01

Automatic Line Network Extraction from Aerial Imangery of Urban Areas Sthrough KnowledghBased Image Analysis N 04 Final Technical ReportI December...Automatic Line Network Extraction from Aerial Imagery of Urban Areas through Knowledge Based Image Analysis Accesion For NTIS CRA&I DTIC TAB 0...paittern re’ognlition. blac’kboardl oriented symbollic processing, knowledge based image analysis , image understanding, aer’ial imsagery, urban area, 17

The Decision to Dismiss General MacArthur

DTIC Science & Technology

1966-04-22

this document can be found in the DTIC ® Technical Report Database. g DISTRIBUTION STATEMENT A. Approved for public release; distribution is... reporters pre- dicting a bloody stalemate unless major additions were made to his forces and new policies formulated by the United Nations. On 20 March...his decision to dismiss General MacArthur and return him to the United States. Due to a report of a leak of this decision to a newspaper, the

Acute toxic effects of single dose dacarbazine: hematological and histological changes in an animal model.

PubMed

Milijašević, B; Stefanović, D; Lalić-Popović, M; Tomić, Z; Kolarović, J; Lalošević, D; Mikov, M

2014-11-01

Treatment of advanced soft tissue sarcoma usually includes dacarbazine (DTIC), an alkylating agent that methylates DNA and is active during all phases of the cell cycle. Common side effects of DTIC include nausea, vomiting, impaired liver and kidney function, myelosuppression, and pneumonia. There are no accounts, however, of histological and hematological changes caused by DTIC. We investigated acute hematological and morphological changes in different organs and in tumors that were caused by a single dose of DTIC. Adult Syrian golden hamsters were inoculated with a suspension of tumorigenic baby hamster kidney (BHK) cells by subcutaneous injection. On day 14 after inoculation, doses of 1.4, 1.6, 1.8 or 2.0 g/m(2) DTIC were injected intraperitoneally into the hamsters. Hamsters in the control group were injected with physiological saline in the same way. Seven days after drug or saline injection the animals were sacrificed and samples of blood, heart, kidney, liver, lungs, spleen, small intestine and tumor were excised, processed and analyzed. Mitoses were counted using an ocular extension with engraved frame. Anemia, thrombocytopenia and leukocytosis were found in the control group of hamsters with fibrosarcoma, whereas animals with fibrosarcoma treated with DTIC developed anemia, thrombocytopenia and leukopenia. Severe pneumonia and moderate hepatitis were detected in all DTIC treated groups. Effects of DTIC on tumor cells included rounding and enlargement of nuclei and rarefaction of chromatin. The number of mitoses was reduced with increasing doses of DTIC. Hepatitis, myelosuppression, pneumonia, and dose-related inhibition of tumor cell proliferation were observed after a single dose of DTIC.

Anti-DR5 monoclonal antibody-mediated DTIC-loaded nanoparticles combining chemotherapy and immunotherapy for malignant melanoma: target formulation development and in vitro anticancer activity.

PubMed

Ding, Baoyue; Wu, Xin; Fan, Wei; Wu, Zhaoyong; Gao, Jing; Zhang, Wei; Ma, Lulu; Xiang, Wang; Zhu, Quangang; Liu, Jiyong; Ding, Xueying; Gao, Shen

2011-01-01

The increased incidence of malignant melanoma in recent decades, along with its high mortality rate and pronounced resistance to therapy pose an enormous challenge. Novel therapeutic strategies, such as immunotherapy and targeted therapy, are urgently needed for melanoma. In this study, a new active targeting drug delivery system was constructed to combine chemotherapy and active specific immunotherapy. The chemotherapeutic drug, dacarbazine (DTIC), that induces apoptosis through the intrinsic pathway which typically responds to severe DNA damage, was used as a model drug to prepare DTIC-loaded polylactic acid (PLA) nanoparticles (DTIC-NPs), which were covalently conjugated to a highly specific targeting functional TRAIL-receptor 2 (DR5) monoclonal antibody (mAb) that can contribute directly to cancer cell apoptosis or growth inhibition through the extrinsic pathway. Our in vitro experiments demonstrated that DTIC-PLA-DR5 mAb nanoparticles (DTIC-NPs-DR5 mAb) are an active targeting drug delivery system which can specifically target DR5-overexpressing malignant melanoma cells and become efficiently internalized. Most strikingly, compared with conventional DTIC-NPs, DTIC-NPs-DR5 mAb showed significantly enhanced cytotoxicity and increased cell apoptosis in DR5-positive malignant melanoma cells. The DTIC-NPs-DR5 mAb described in this paper might be a potential formulation for targeting chemotherapy and immunotherapy to DR5-overexpressing metastatic melanoma.

Mechanism of UVA-dependent DNA damage induced by an antitumor drug dacarbazine in relation to its photogenotoxicity.

PubMed

Iwamoto, Takuya; Hiraku, Yusuke; Okuda, Masahiro; Kawanishi, Shosuke

2008-03-01

It has been reported that dacarbazine (DTIC) is photogenotoxic. The purpose of this study is to clarify the mechanism of photogenotoxicity induced by DTIC. We examined DNA damage induced by UVA-irradiated DTIC using 32P-5'-end-labeled DNA fragments obtained from human genes. Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in calf thymus DNA was measured by high performance liquid chromatograph with an electrochemical detector. Electron spin resonance (ESR) spin-trapping experiments were performed to detect radical species generated from UVA-irradiated DTIC. UVA-irradiated DTIC caused DNA damage at guanine residues, especially at the 5'-GGT-3' sequence in the presence of Cu(II) and also induced 8-oxodG generation in calf thymus DNA. DTIC-induced photodamage to DNA fragments was partially inhibited by catalase, whereas 8-oxodG formation was significantly increased by catalase. NaN3, a carbene scavenger, inhibited DNA damage and 8-oxodG formation in a dose-dependent manner, suggesting that carbene intermediates are involved. The ESR spin-trapping experiments demonstrated the generation of aryl radicals in the process of photodegradation of DTIC. Photoactivated DTIC generates the carbene and aryl radicals, which may induce both DNA adduct and 8-oxodG formation, resulting in photogenotoxicity. This study could provide an insight into the safe usage of DTIC.

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2013-06-14

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Computer Supported Indexing: A History and Evaluation of NASA's MAI System

NASA Technical Reports Server (NTRS)

Silvester, June P.

1997-01-01

Computer supported or machine aided indexing (MAI) can be categorized in multiple ways. The system used by the National Aeronautics and Space Administration's (NASA's) Center for AeroSpace Information (CASI) is described as semantic and computational. It's based on the co-occurrence of domain-specific terminology in parts of a sentence, and the probability that an indexer will assign a particular index term when a given word or phrase is encountered in text. The NASA CASI system is run on demand by the indexer and responds in 3 to 9 seconds with a list of suggested, authorized terms. The system was originally based on a syntactic system used in the late 1970's by the Defense Technical Information Center (DTIC). The NASA mainframe-supported system consists of three components: two programs and a knowledge base (KB). The evolution of the system is described and flow charts illustrate the MAI procedures. Tests used to evaluate NASA's MAI system were limited to those that would not slow production. A very early test indicated that MAI saved about 3 minutes and provided several additional terms for each document indexed. It also was determined that time and other resources spent in careful construction of the KB pay off with high-quality output and indexer acceptance of MAI results.

Anti-DR5 monoclonal antibody-mediated DTIC-loaded nanoparticles combining chemotherapy and immunotherapy for malignant melanoma: target formulation development and in vitro anticancer activity

PubMed Central

Ding, Baoyue; Wu, Xin; Fan, Wei; Wu, Zhaoyong; Gao, Jing; Zhang, Wei; Ma, Lulu; Xiang, Wang; Zhu, Quangang; Liu, Jiyong; Ding, Xueying; Gao, Shen

2011-01-01

Background The increased incidence of malignant melanoma in recent decades, along with its high mortality rate and pronounced resistance to therapy pose an enormous challenge. Novel therapeutic strategies, such as immunotherapy and targeted therapy, are urgently needed for melanoma. In this study, a new active targeting drug delivery system was constructed to combine chemotherapy and active specific immunotherapy. Methods The chemotherapeutic drug, dacarbazine (DTIC), that induces apoptosis through the intrinsic pathway which typically responds to severe DNA damage, was used as a model drug to prepare DTIC-loaded polylactic acid (PLA) nanoparticles (DTIC-NPs), which were covalently conjugated to a highly specific targeting functional TRAIL-receptor 2 (DR5) monoclonal antibody (mAb) that can contribute directly to cancer cell apoptosis or growth inhibition through the extrinsic pathway. Results Our in vitro experiments demonstrated that DTIC-PLA-DR5 mAb nanoparticles (DTIC-NPs-DR5 mAb) are an active targeting drug delivery system which can specifically target DR5-overexpressing malignant melanoma cells and become efficiently internalized. Most strikingly, compared with conventional DTIC-NPs, DTIC-NPs-DR5 mAb showed significantly enhanced cytotoxicity and increased cell apoptosis in DR5-positive malignant melanoma cells. Conclusion The DTIC-NPs-DR5 mAb described in this paper might be a potential formulation for targeting chemotherapy and immunotherapy to DR5-overexpressing metastatic melanoma. PMID:21976975

Senior Leadership: An Annotated Bibliography of the Military and Nonmilitary Literature

DTIC Science & Technology

1981-06-01

by describing well over 100 principles of management . 3-09. Drucker , P. F. The Effective Executive. London: Heinemann, 1967. A "self-training" book by... MANAGEMENT TECHNICAL AREA DTIC S.JUN 2 aM2 U.S. Army Research Institute for the Behavioral and Social Sciences i-JJune 1981 Approved for public release...revrose aide If neceesry ind Identify by block number) Senior leadership Leadership skills Leadership Colonels Leadership functions Management General

Exploring Broad Area Quantum Cascade Lasers

DTIC Science & Technology

2017-10-01

Research Laboratory AFRL /RDLTD 3550 Aberdeen Ave SE Kirtland AFB, NM 87117-5776 11. SPONSOR/MONITOR’S REPORT NUMBER(S) AFRL -RD-PS-TP-2017-0008 12...LIST DTIC/OCP 8725 John J. Kingman Rd, Suite 0944 Ft Belvoir, VA 22060-6218 1 cy AFRL /RVIL Kirtland AFB, NM 87117-5776 1 cy Chunte Lu... AFRL -RD-PS- AFRL -RD-PS- TP-2017-0008 TP-2017-0008 EXPLORING BROAD AREA QUANTUM CASCADE LASERS Tim Newell, et. al. 1 October 2017 Technical

The NATO thesaurus project

NASA Technical Reports Server (NTRS)

Krueger, Jonathan

1990-01-01

This document describes functionality to be developed to support the NATO technical thesaurus. Described are the specificity of the thesaurus structure and function; the distinction between the thesaurus information and its representation in a given online, machine readable, or printed form; the enhancement of the thesaurus with the assignment of COSATI codes (fields and groups) to posting terms, the integration of DTIC DRIT and NASA thesauri related terminology, translation of posting terms into French; and the provision of a basis for system design.

U.S. Army Delayed Entry Program Optimization Model

DTIC Science & Technology

2004-08-01

United States Military Academy West Point, New York 10996 OPERATIONS RESEARCH CENTER OF EXCELLENCE TECHNICAL REPORT No. DSE-TR- 0428 DTIC #: ADAXXXXX...following entries: Author(s) Department of Systems Engineering 2 Mahan Hall West Point, NY 10996 Client USAAC CAR 4 1307 Third Ave., Fort Knox, KY 40121...Wolter, LTC Michael J. Kwinn, Jr., LTC John Halstead DSE-R- 0428 5S. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8

Organizational Effectiveness: Development and Validation of Integrated Models. Report II. Empirical Studies of Organizational Effectiveness Using Multivariate Models

DTIC Science & Technology

1982-04-01

34 ’Institute for Social Research LEADERSHIP AND MANAGEMENT TECHNICAL AREA DTIC ~EL ECT-ICI /AUG 2 1983 U. S. Army D C3 Research Institute for the Behavioral and...about or aIlowing changes within the organizatin itself (Georgopoulos, 1972; Georgopoulos & Tannenbaum, 1957). As open systems, organizations and their...in school organizations. Unpublished manuscript, The University of Michigan, 1980. Selznick, P. Leadership in administration. Evanston, Ill.: Row

Unified Theory of Inference for Text Understanding

DTIC Science & Technology

1986-11-25

Technical Report S. L. Graham Principal Investigator (4151 642-2059 DTIC ^ELECTE APR 2 21987 D "The views and conclusions contained in this document...obtain X? Function - Infer P will use X for its normal purpose, if it has one. Intervention - How could C keep P from obtaining X? Knowledge Propagation...likelihood is low otherwise, likelihood is moderate otherwise, does X have a normal function ? if so, does P do actions like this function ? if so

C-9A Interior Noise Evaluation.

DTIC Science & Technology

1983-02-01

OEHL REPORK 83-101EH174BNA Cqk C-9A INTERIOR NOISE EVALUATION FEBRUARY 1983 DTIC $! ELECTE 0 Lj" __ B DIUTFION STATEMENT A [ Appoved for public releasq...may in any way be related thereto. The mention of trade names or commercial products in this publication is for illustration purposes and does not...the Public Affa.rs Office and is releasable to the National Technical Information Service (NTIS). At NTIS, it will be available to the general public

Institute for Defense Analyses Tactical Warfare (TACWAR) Model. Program Maintenance Manual. Part II.

DTIC Science & Technology

1977-09-06

Accession For XTIS GRA&I DTIC TAB U1nannounced Q Just if latlon B vl an/o .0EgsTe. Distriution l3L-j b ’On/ n4I Availbilit Code CONTENTS Section Page...the TACWAR modeln xx GLOSSARY Abbreviation -Meaning AAA antiaircraft artillery ABA airbase attacker * ABAE airbase attacker escort ABAS airbase...Do011010 End KS: .. US 001102 rsr ll rlOf do 1001) K spoft O tad-mi IDT *)WISIT 10046 ,tca ft K fmUt dhl IST INS ____nl ABA mcNOA Es AZ *in

75 FR 78619 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-16

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 216 and 237 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations... the Defense Federal Acquisition Regulation Supplement (DFARS) to set forth references to supplementary...

32 CFR 37.895 - How is the final performance report to be sent to the Defense Technical Information Center?

Code of Federal Regulations, 2014 CFR

2014-07-01

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32 CFR 37.895 - How is the final performance report to be sent to the Defense Technical Information Center?

Code of Federal Regulations, 2011 CFR

2011-07-01

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Targeting nodal in conjunction with dacarbazine induces synergistic anticancer effects in metastatic melanoma.

PubMed

Hardy, Katharine M; Strizzi, Luigi; Margaryan, Naira V; Gupta, Kanika; Murphy, George F; Scolyer, Richard A; Hendrix, Mary J C

2015-04-01

Metastatic melanoma is a highly aggressive skin cancer with a poor prognosis. Despite a complete response in fewer than 5% of patients, the chemotherapeutic agent dacarbazine (DTIC) remains the reference drug after almost 40 years. More recently, FDA-approved drugs have shown promise but patient outcome remains modest, predominantly due to drug resistance. As such, combinatorial targeting has received increased attention, and will advance with the identification of new molecular targets. One attractive target for improving melanoma therapy is the growth factor Nodal, whose normal expression is largely restricted to embryonic development, but is reactivated in metastatic melanoma. In this study, we sought to determine how Nodal-positive human melanoma cells respond to DTIC treatment and to ascertain whether targeting Nodal in combination with DTIC would be more effective than monotherapy. A single treatment with DTIC inhibited cell growth but did not induce apoptosis. Rather than reducing Nodal expression, DTIC increased the size of the Nodal-positive subpopulation, an observation coincident with increased cellular invasion. Importantly, clinical tissue specimens from patients with melanomas refractory to DTIC therapy stained positive for Nodal expression, both in pre- and post-DTIC tumors, underscoring the value of targeting Nodal. In vitro, anti-Nodal antibodies alone had some adverse effects on proliferation and apoptosis, but combining DTIC treatment with anti-Nodal antibodies decreased cell growth and increased apoptosis synergistically, at concentrations incapable of producing meaningful effects as monotherapy. Targeting Nodal in combination with DTIC therapy holds promise for the treatment of metastatic melanoma. ©2015 American Association for Cancer Research.

Dacarbazine combined targeted therapy versus dacarbazine alone in patients with malignant melanoma: a meta-analysis.

PubMed

Jiang, Guan; Li, Rong-Hua; Sun, Chao; Liu, Yan-Qun; Zheng, Jun-Nian

2014-01-01

Malignant melanoma is the most aggressive and deadly form of skin cancer. Dacarbazine (DTIC) has been the approved first-line treatment for metastatic melanoma in routine clinical practice. However, response rates with single-agent DTIC are low. The objective of this study was to compare the efficacy and safety of DTIC with or without placebo and DTIC-based combination therapies in patients with advanced metastatic melanoma. We searched from electronic databases such as The Cochrane Library, MEDLINE, EBSCO, EMBASE, Ovid, CNKI, and CBMDisc from 2003 to 2013. The primary outcome measures were overall response and 1-year survival, and the secondary outcome measurements were adverse events. Nine randomized controlled trials (RCTs) involving 2,481 patients were included in the meta-analysis. DTIC-based combination therapies was superior to DTIC alone in overall response (combined risk ratio [RR]  = 1.60, 95% confidence interval [CI]: 1.27-2.01) and 1-year survival (combined RR = 1.26, 95% CI: 1.14-1.39). Patients with DTIC-based combination therapies had higher incidence of adverse events including nausea (combined RR = 1.23, 95% CI: 1.10-1.36), vomiting (combined RR = 1.73, 95% CI: 1.41-2.12) and neutropenia (combined RR = 1.75, 95% CI: 1.42-2.16) compared to the group for DTIC alone. These data suggested that DTIC-based combination therapies could moderately improve the overall response and the 1-year survival but increased the incidence of adverse events. Further large-scale, high-quality, placebo-controlled, double-blind trials are needed to confirm this conclusion.

Targeting Nodal in Conjunction with Dacarbazine Induces Synergistic Anti-cancer Effects in Metastatic Melanoma

PubMed Central

Hardy, Katharine M.; Strizzi, Luigi; Margaryan, Naira V.; Gupta, Kanika; Murphy, George F.; Scolyer, Richard A.; Hendrix, Mary J.C.

2015-01-01

Metastatic melanoma is a highly aggressive skin cancer with a poor prognosis. Despite a complete response in fewer than 5% of patients, the chemotherapeutic agent Dacarbazine (DTIC) remains the reference drug after almost 40 years. More recently FDA approved drugs have shown promise but patient outcome remains modest, predominantly due to drug resistance. As such, combinatorial targeting has received increased attention, and will advance with the identification of new molecular targets. One attractive target for improving melanoma therapy is the growth factor Nodal, whose normal expression is largely restricted to embryonic development, but is reactivated in metastatic melanoma. In this study, we sought to determine how Nodal-positive human melanoma cells respond to DTIC treatment and to ascertain if targeting Nodal in combination with DTIC would be more effective than monotherapy. A single treatment with DTIC inhibited cell growth but did not induce apoptosis. Rather than reducing Nodal expression, DTIC increased the size of the Nodal-positive subpopulation, an observation coincident with increased cellular invasion. Importantly, clinical tissue specimens from patients with melanomas refractory to DTIC therapy stained positive for Nodal expression, both in pre- and post-DTIC tumors, underscoring the value of targeting Nodal. In vitro, anti-Nodal antibodies alone had some adverse effects on proliferation and apoptosis, but combining DTIC treatment with anti-Nodal antibodies decreased cell growth and increased apoptosis synergistically, at concentrations incapable of producing meaningful effects as monotherapy. Implications Targeting Nodal in combination with DTIC therapy holds promise for the treatment of metastatic melanoma. PMID:25767211

Effect of dacarbazine on CD44 in live melanoma cells as measured by atomic force microscopy-based nanoscopy.

PubMed

Huang, Xun; He, Jiexiang; Zhang, Huan-Tian; Sun, Kai; Yang, Jie; Wang, Huajun; Zhang, Hongxin; Guo, Zhenzhao; Zha, Zhen-Gang; Zhou, Changren

2017-01-01

CD44 ligand-receptor interactions are known to be involved in regulating cell migration and tumor cell metastasis. High expression levels of CD44 correlate with a poor prognosis of melanoma patients. In order to understand not only the mechanistic basis for dacarbazine (DTIC)-based melanoma treatment but also the reason for the poor prognosis of melanoma patients treated with DTIC, dynamic force spectroscopy was used to structurally map single native CD44-coupled receptors on the surface of melanoma cells. The effect of DTIC treatment was quantified by the dynamic binding strength and the ligand-binding free-energy landscape. The results demonstrated no obvious effect of DTIC on the unbinding force between CD44 ligand and its receptor, even when the CD44 nanodomains were reduced significantly. However, DTIC did perturb the kinetic and thermodynamic interactions of the CD44 ligand-receptor, with a resultant greater dissociation rate, lower affinity, lower binding free energy, and a narrower energy valley for the free-energy landscape. For cells treated with 25 and 75 μg/mL DTIC for 24 hours, the dissociation constant for CD44 increased 9- and 70-fold, respectively. The CD44 ligand binding free energy decreased from 9.94 for untreated cells to 8.65 and 7.39 kcal/mol for DTIC-treated cells, which indicated that the CD44 ligand-receptor complexes on DTIC-treated melanoma cells were less stable than on untreated cells. However, affinity remained in the micromolar range, rather than the millimolar range associated with nonaffinity ligands. Hence, the CD44 receptor could still be activated, resulting in intracellular signaling that could trigger a cellular response. These results demonstrate DTIC perturbs, but not completely inhibits, the binding of CD44 ligand to membrane receptors, suggesting a basis for the poor prognosis associated with DTIC treatment of melanoma. Overall, atomic force microscopy-based nanoscopic methods offer thermodynamic and kinetic insight into the effect of DTIC on the CD44 ligand-binding process.

Effect of dacarbazine on CD44 in live melanoma cells as measured by atomic force microscopy-based nanoscopy

PubMed Central

Huang, Xun; He, Jiexiang; Zhang, Huan-tian; Sun, Kai; Yang, Jie; Wang, Huajun; Zhang, Hongxin; Guo, Zhenzhao; Zha, Zhen-gang; Zhou, Changren

2017-01-01

CD44 ligand–receptor interactions are known to be involved in regulating cell migration and tumor cell metastasis. High expression levels of CD44 correlate with a poor prognosis of melanoma patients. In order to understand not only the mechanistic basis for dacarbazine (DTIC)-based melanoma treatment but also the reason for the poor prognosis of melanoma patients treated with DTIC, dynamic force spectroscopy was used to structurally map single native CD44-coupled receptors on the surface of melanoma cells. The effect of DTIC treatment was quantified by the dynamic binding strength and the ligand-binding free-energy landscape. The results demonstrated no obvious effect of DTIC on the unbinding force between CD44 ligand and its receptor, even when the CD44 nanodomains were reduced significantly. However, DTIC did perturb the kinetic and thermodynamic interactions of the CD44 ligand–receptor, with a resultant greater dissociation rate, lower affinity, lower binding free energy, and a narrower energy valley for the free-energy landscape. For cells treated with 25 and 75 μg/mL DTIC for 24 hours, the dissociation constant for CD44 increased 9- and 70-fold, respectively. The CD44 ligand binding free energy decreased from 9.94 for untreated cells to 8.65 and 7.39 kcal/mol for DTIC-treated cells, which indicated that the CD44 ligand–receptor complexes on DTIC-treated melanoma cells were less stable than on untreated cells. However, affinity remained in the micromolar range, rather than the millimolar range associated with nonaffinity ligands. Hence, the CD44 receptor could still be activated, resulting in intracellular signaling that could trigger a cellular response. These results demonstrate DTIC perturbs, but not completely inhibits, the binding of CD44 ligand to membrane receptors, suggesting a basis for the poor prognosis associated with DTIC treatment of melanoma. Overall, atomic force microscopy-based nanoscopic methods offer thermodynamic and kinetic insight into the effect of DTIC on the CD44 ligand-binding process. PMID:29296081

Coupled Research in Ocean Acoustics and Signal Processing for the Next Generation of Underwater Acoustic Communication Systems

DTIC Science & Technology

2016-08-05

JPAnalytics LLC CC: DCMA Boston DTIC Director, NRL Progress Report #8 Coupled Research in Ocean Acoustics and Signal Processing for the Next...Generation of Underwater Acoustic Communication Systems Principal Investigator’s Name: Dr. James Preisig Period Covered By Report: 1/20/2016 to 4/19/2016...Technical work this period has spanned two areas. The first of these is VHF Acoustics . During this time period, the Principle Investigator worked with Dr

Engineering Development Tests Airdrop Controlled Exit System (ACES)

DTIC Science & Technology

1980-09-01

AIRDROP CONTROLLED EXIT SYSTEM ( ACES ) RECOVERY PARACHUTES TELEMETERING DATA 20. D5TFAC c• Cat •u•u am revers e• ift n•ceesafy ad Ide•lityf by block...rTECHNICAL REPORT , NATICK /TR-82 /017 f C’n Engineering Development Tests Airdropý Controlled Exit System ( ACES ) COPY CLV40ble to DTIC doe’ io C...and,50.,,,10) s. TYPE OF REPORT A PERIOn COVEnEo Test Report ENCINEERTNG DEVELOPMENT TESTS Oct 79 - Apr 80 AIRDROP CONTROLLED EXIT SYSTEM ( ACES ) 6

A Proposed Mechanism of Neuronal Injury in Pilots and Aircrew Personnel with Hypobaric Exposure

DTIC Science & Technology

2017-04-22

Technical Information Center (DTIC). DATE March 14, 2017 14. 59 MOW PRIMARY POINT OF CONTACT (Last Name, First Name, M.I., email) 15. DUTY PHONE/PAGER...will appear in the manuscript. LAST NAME, FIRST NAME AND M.I. GRADE/RANK SQUADRON/GROUP/OFFICE SYMBOL INSTITUTION (If not 59 MOW) a. Primary ...34,·" ••• • • U-2 pilots display an increased incidence of white-matter hyperintensities (WMH) on MRI compared to healthy age -matched controls (non-pilots

SocioEconomic Characteristics of the All Volunteer Force: Evidence from the National Longitudinal Survey, 1979

DTIC Science & Technology

1982-02-01

Fredland 0>-and DTIC Roger D. Little ELECTE 1 Economics Department S JUL 6 1982 U.S. Naval Academy Annapolis, Maryland 21402 D DISTRIBUTION STATEMENT A...NATIONAL LONGITUDINAL SURVEY, 1979 by J. Eric Fredland and Roger D. Little Economics Department U.S. Naval Academy Annapolis, MD 21402 ii; DISTRIBUTION...comments, Steven Lerch for technical assis- tance, and Doris Keating for typing support. i. 4 I• I SECURITY CLASSIFICATIONI OF THIS PAGE (When Dal* EnterNAU

Contamination Assessment Report, Site 26-6: Basin F. Version 3.3. Phase 1

DTIC Science & Technology

1988-05-01

88173R02 AD-A2 7 5 700 -’ lEtUIUI LITIGATION TECHNICAL SUPPORT AND SERVICES Rocky Mountain Arsenal DTIC r ELECTF- FINAL PHASE I Q FEB7 1994...PREPARED BY ENVIRONMENTAL SCIENCE AND ENGINEERING, INC. Harding Lawson Associates Midwest Research Institute (Prepared under Task 19) Rocky- Mountain ...Arspn• FILE COP y Information Center PREPARED FOR Commerce City, Colorad U.S. ARMY PROGRAM MANAGER’S OFFICE FOR ROCKY MOUNTAIN ARSENAL THE INFORMATION

Control Charts When the Observations Are Correlated.

DTIC Science & Technology

1987-05-01

l7 D-AiB6 388 CONTROL CHARTS WHEN THE OBSERVATIONS ARE CORRELATED(J) i/iPITTSBURGH UNIV PA CENTER FOR KULTIVARIATE ANALYSIS P R KRISHNAIAH ET AL MAY... Krishnaiah and B. Q. Miao F-49620-85-C-0008 S. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT. TASK AREA II WORK UNIT NUMBERS... Krishnaiah and B.Q. Miao Center for Multivariate Analysis University of Pittsburgh N DTIC E L 1Zk-, -I- OCT0 11987 Play 1987 Technical Report No. 87-09

Finite Birth-and-Death Models in Randomly Changing Environments.

DTIC Science & Technology

1982-02-01

7 AD-AL14 188 NAVAL POSTGRADUATE SCHOOL MONTEREY CA F/ 12/2 FINITE BIRTH-AND-DEATH MODELS IN RANDOMLY CHANGING ENVROENTS-(TC(U) FEB 82 D P 6AVER...Monterey, California DTIC $ELECTEMAY6 1982 B FINITE BIRTH-AND-DEATH MODELS IN RANDOMLY CHANGING ENVIRONMENTS by D. P. Gayer P. A. Jacobs G. Latouche February...CATALOG NUMUEi4NPS55-82-007 [iI. (. 4. TITLE (d Subtitle) S. TYPE OF REPORT A PERIOO COVERED FINITE BIRTH-AND-DEATH MODELS IN RANDOMLY Technical

Advanced Rechargeable Lithium Sulfur Dioxide Cell

DTIC Science & Technology

1991-11-01

AD-A274 908IIIIlIIIE McDonald , P. Harris, F. Goebel, S. Hossi ierra, M. Guentert, C. Todino 7 ad r nse TECHNICAL PRODUCTS INCY DTIC ELECTE JAN26 1994...Pawcatuck, CT 06379 94-02298 1425 Best Available Copy I ADVANCED RECHARGEABLE LITHIUM SULFUR DIOXIDE CELL I R.C. McDonald , P. Harris, F. Goebel, S. Hossain...20 minutes. The electrochemical measurements were carried out using a I Starbuck 20-station cycler system which is connected to a computer to monitor

Machine Learning

DTIC Science & Technology

1990-04-01

DTIC i.LE COPY RADC-TR-90-25 Final Technical Report April 1990 MACHINE LEARNING The MITRE Corporation Melissa P. Chase Cs) CTIC ’- CT E 71 IN 2 11990...S. FUNDING NUMBERS MACHINE LEARNING C - F19628-89-C-0001 PE - 62702F PR - MOlE S. AUTHO(S) TA - 79 Melissa P. Chase WUT - 80 S. PERFORMING...341.280.5500 pm I " Aw Sig rill Ia 2110-01 SECTION 1 INTRODUCTION 1.1 BACKGROUND Research in machine learning has taken two directions in the problem of

A User’s Manual for: Electromagnetic Surface Patch Code (ESP).

DTIC Science & Technology

1981-07-01

NEWMAN DAAG29-81-K-0020 UNCLASSIFIED ESL-713402- 1 AR0-17UU6.1-EL NL I OF | AD A 10 5 954 END DATE FILMED II-.8I1 DTIC SM * - III 1.0 :s...ma III ̂ ^= • ilia II I.I III— = 11.25 [I 11.4 1 ^6 t v 1 ...Ohio State University ElectroScience Laboratory Department of Electrical Engineering Columbu», Ohio 43212 Technical Report 713402- 1 Grant Number

22 CFR 125.1 - Exports subject to this part.

Code of Federal Regulations, 2011 CFR

2011-04-01

... EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.1 Exports subject to this part. (a) The controls of this part apply to the export of technical data and the export of classified defense articles... defense articles if the technical data is determined by the Directorate of Defense Trade Controls to be...

78 FR 13543 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 201, 204, 215, 225, 227, 242, 245, and 252 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is...

76 FR 27274 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 225 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations System... Federal Acquisition Regulation Supplement (DFARS) to direct contracting officers to additional guidance on...

Dacarbazine Combined Targeted Therapy versus Dacarbazine Alone in Patients with Malignant Melanoma: A Meta-Analysis

PubMed Central

Jiang, Guan; Li, Rong-Hua; Sun, Chao; Liu, Yan-Qun; Zheng, Jun-Nian

2014-01-01

Background Malignant melanoma is the most aggressive and deadly form of skin cancer. Dacarbazine (DTIC) has been the approved first-line treatment for metastatic melanoma in routine clinical practice. However, response rates with single-agent DTIC are low. The objective of this study was to compare the efficacy and safety of DTIC with or without placebo and DTIC-based combination therapies in patients with advanced metastatic melanoma. Methods We searched from electronic databases such as The Cochrane Library, MEDLINE, EBSCO, EMBASE, Ovid, CNKI, and CBMDisc from 2003 to 2013. The primary outcome measures were overall response and 1-year survival, and the secondary outcome measurements were adverse events. Results Nine randomized controlled trials (RCTs) involving 2,481 patients were included in the meta-analysis. DTIC-based combination therapies was superior to DTIC alone in overall response (combined risk ratio [RR]  = 1.60, 95% confidence interval [CI]: 1.27–2.01) and 1-year survival (combined RR = 1.26, 95% CI: 1.14–1.39). Patients with DTIC-based combination therapies had higher incidence of adverse events including nausea (combined RR = 1.23, 95% CI: 1.10–1.36), vomiting (combined RR = 1.73, 95% CI: 1.41–2.12) and neutropenia (combined RR = 1.75, 95% CI: 1.42–2.16) compared to the group for DTIC alone. Conclusion These data suggested that DTIC-based combination therapies could moderately improve the overall response and the 1-year survival but increased the incidence of adverse events. Further large-scale, high-quality, placebo-controlled, double-blind trials are needed to confirm this conclusion. PMID:25502446

Selective toxicity of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide toward hypoxic mammalian cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rauth, A.M.; Mohindra, J.K.

1981-12-01

The chemotherapeutic agent 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) is used in the treatment of malignant melanoma where response rates of 15 to 30% have been reported. Some current interest exists in combining DTIC chemotherapy with localized high-dose (800 rads)-per-fraction radiotherapy in the treatment of unresectable metastatic melanoma. The present work investigates the radiosensitizing and chemotherapeutic properties of DTIC in an in vitro system using Chinese hamster ovary or HeLa cells and in vivo, using the KHT transplantable murine tumor. No evidence of a radiosensitizing effect of DTIC was found towards hypoxic or aerobic cells either in vitro or in vivo. In vitro, highmore » drug concentrations (1 mg/ml) were approximately 5 times more effective in killing hypoxic Chinese hamster ovary or HeLa cells than in killing aerobic cells over exposure times of 0 to 12 hr. The degree of toxicity was drug dose and temperature dependent but was not highly dependent on cell number or cell type. In vivo plasma levels of DTIC were measured with high-pressure liquid chromatography after i.p. injection of drug into C3H mice. At the highest drug doses tested, near the 50% lethal dose in mice for DTIC (0.5 mg/g), the drug was toxic to both aerobic and hypoxic tumor cells with some evidence of increased toxicity towards hypoxic cells. The present work suggests that DTIC may be more efficiently activated under hypoxic conditions as compared to aerobic conditions. The increased toxicity of DTIC under hypoxic versus aerobic conditions may prove to be a feature of this drug that can be exploited in its clinical use and in the design of new analogs of DTIC.« less

22 CFR 126.17 - Exemption pursuant to the Defense Trade Cooperation Treaty between the United States and the...

Code of Federal Regulations, 2014 CFR

2014-04-01

...) and (j)(1)(ii) of this section; (ii) Technical data (including data packages, technical papers... entity or person who receives, but does not have access to, defense articles, including technical data...) Defense articles (other than technical data) shall be individually labeled with the appropriate...

32 CFR 159.6 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

...://www.dtic.mil/whs/directives/corres/pdf/520008r.pdf. 10 Available athttp://www.dtic.mil/whs/directives... hostile acts or demonstrated hostile intent. 11 Available athttp://www.dtic.mil/whs/directives/corres/pdf/110022p.pdf. (D) Documentation of individual training covering weapons familiarization and qualification...

Consideration of Preventing Local Venous Pain by Dacarbazine.

PubMed

Ohtsubo, Tatsuya; Tsuji, Takumi; Umeyama, Takayo; Sudou, Miho; Komesu, Kana; Matsumoto, Minako; Yoshida, Yuya; Banno, Rie; Tomogane, Kanji; Fujita, Atsuo; Kohno, Takeyuki; Mikami, Tadashi

2017-01-01

Local venous pain caused by dacarbazine (DTIC) injection is due to its photodegradation product 5-diazoimidazole-4-carboxamide (Diazo-IC). The production of Diazo-IC can be decreased by protecting the drug from light. Furthermore, the production of Diazo-IC reportedly increases with time; however, there are no studies reporting the association between the injection preparation time and local venous pain caused by the DTIC injection. We evaluated the efficacy of the following: (1) method used to shorten the injection preparation time and (2) method used to change the diluting solution for DTIC. We found that shortening the injection preparation time tended to decrease the local venous pain expression due to DTIC, and Veen F decreased the production of Diazo-IC compared with the normal saline and 5% glucose solution. These results indicate that shortening the injection preparation time may be effective in preventing the local venous pain caused by the DTIC injection; moreover, using Veen F for DTIC may also reduce the pain.

Phase I–II study of plitidepsin and dacarbazine as first-line therapy for advanced melanoma

PubMed Central

Plummer, R; Lorigan, P; Brown, E; Zaucha, R; Moiseyenko, V; Demidov, L; Soriano, V; Chmielowska, E; Andrés, R; Kudryavtseva, G; Kahatt, C; Szyldergemajn, S; Extremera, S; de Miguel, B; Cullell-Young, M; Calvert, H

2013-01-01

Background: This phase I–II trial compared plitidepsin 1-h infusion alone or combined with dacarbazine (DTIC) 1-h infusion as front-line therapy for advanced melanoma. Methods: The recommended dose (RD) for plitidepsin/DTIC was defined in the first stage. In the second stage, patients were randomised to receive single-agent plitidepsin 3.2 mg m−2 (n=20) on days 1, 8 and 15 every 4 weeks (q4wk) or plitidepsin 2.4 mg m−2 on days 1, 8 and 15 q4wk combined with DTIC 800 mg m−2 q4wk (n=38). Results: The overall response rate with plitidepsin/DTIC was 21.4% all responders had normal serum lactate dehydrogenase (LDH) levels and performance status ⩽1 at baseline. Median progression-free survival (PFS) with plitidepsin/DTIC was 3.3 months in all patients, and 4.3 months in those with baseline normal LDH. No responses occurred with single-agent plitidepsin and median PFS was 1.5 months. Both regimens were well tolerated. Haematological abnormalities were more common and transaminase increases more severe with plitidepsin/DTIC. Treatment-related transaminase increases leading to infusion omission on day 8 were relatively common. No drug–drug pharmacokinetic interactions were found. Conclusion: This plitidepsin/DTIC schedule has antitumour activity and manageable toxicity in advanced melanoma. Further evaluation of plitidepsin 2.4 mg m−2 fortnightly and DTIC 800 mg m−2 q4wk is recommended. PMID:23989947

Phase I-II study of plitidepsin and dacarbazine as first-line therapy for advanced melanoma.

PubMed

Plummer, R; Lorigan, P; Brown, E; Zaucha, R; Moiseyenko, V; Demidov, L; Soriano, V; Chmielowska, E; Andrés, R; Kudryavtseva, G; Kahatt, C; Szyldergemajn, S; Extremera, S; de Miguel, B; Cullell-Young, M; Calvert, H

2013-09-17

This phase I-II trial compared plitidepsin 1-h infusion alone or combined with dacarbazine (DTIC) 1-h infusion as front-line therapy for advanced melanoma. The recommended dose (RD) for plitidepsin/DTIC was defined in the first stage. In the second stage, patients were randomised to receive single-agent plitidepsin 3.2 mg m(-2) (n = 20) on days 1, 8 and 15 every 4 weeks (q4wk) or plitidepsin 2.4 mg m(-2) on days 1, 8 and 15 q4wk combined with DTIC 800 mg m(-2) q4wk (n = 38). The overall response rate with plitidepsin/DTIC was 21.4%; all responders had normal serum lactate dehydrogenase (LDH) levels and performance status ≤ 1 at baseline. Median progression-free survival (PFS) with plitidepsin/DTIC was 3.3 months in all patients, and 4.3 months in those with baseline normal LDH. No responses occurred with single-agent plitidepsin and median PFS was 1.5 months. Both regimens were well tolerated. Haematological abnormalities were more common and transaminase increases more severe with plitidepsin/DTIC. Treatment-related transaminase increases leading to infusion omission on day 8 were relatively common. No drug-drug pharmacokinetic interactions were found. This plitidepsin/DTIC schedule has antitumour activity and manageable toxicity in advanced melanoma. Further evaluation of plitidepsin 2.4 mg m(-2) fortnightly and DTIC 800 mg m(-2) q4wk is recommended.

Orally administered rapamycin, dacarbazine or both for treatment of human melanoma evaluated in severe combined immunodeficiency mice.

PubMed

Thallinger, Christiane; Skorjanec, Sophie; Soleiman, Afschin; Tzaneva, Stanislava; Griss, Johannes; Rous, Wolfgang; Poeppl, Wolfgang; Weinlich, Georg; Karimian-Teherani, Daniela; Joukhadar, Christian

2008-01-01

In this experimental study, the antineoplastic potential of orally administered rapamycin in human melanoma was evaluated and compared with dacarbazine (DTIC) as well as with the antineoplastic effect of the combination of both drugs. The substances were tested using 2 human melanoma cell lines, 518A2, which is highly susceptible to DTIC, and 607B, which is moderately susceptible. A human melanoma severe combined immunodeficiency mouse xenotransplantation model was used. After development of palpable tumors, mice received oral rapamycin or saline over 18 days. Additionally, from treatment day 4 to 8, mice were randomly chosen to receive either DTIC or saline treatment. The oral rapamycin treatment (1.5, 7.5, 15 and 30 mg/kg body weight) had an antineoplastic effect, ranging from 35 to 78% tumor weight reduction compared with the saline group. In DTIC less sensitive 607B tumors, rapamycin treatment (15 and 30 mg/kg body weight) was superior to DTIC treatment (p < 0.05). DTIC monotreatment reduced tumor weight in 518A2 tumors by 85% on average, whereas in 607B xenografts, no significant tumor weight reduction was observed compared with the saline group (p > 0.05). The combination of rapamycin and DTIC was not superior to rapamycin monotreatment in any cell line. These data indicate that oral rapamycin exerts a relevant antineoplastic effect on human melanoma cells. This effect appeared to be more pronounced in DTIC less sensitive melanoma xenografts. Copyright 2008 S. Karger AG, Basel.

32 CFR 108.2 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Internet at http://www.dtic.mil/whs/directives/corres/pdf/300005p.pdf. 2 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/220502p.pdf. 3 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/231008p.pdf. ...

32 CFR 108.2 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Internet at http://www.dtic.mil/whs/directives/corres/pdf/300005p.pdf. 2 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/220502p.pdf. 3 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/231008p.pdf. ...

32 CFR 108.2 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Internet at http://www.dtic.mil/whs/directives/corres/pdf/300005p.pdf. 2 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/220502p.pdf. 3 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/231008p.pdf. ...

48 CFR 235.010 - Scientific and technical reports.

Code of Federal Regulations, 2014 CFR

2014-10-01

... reports. 235.010 Section 235.010 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.010 Scientific and technical reports. (b) For DoD, the Defense Technical Information Center is...

48 CFR 235.010 - Scientific and technical reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... reports. 235.010 Section 235.010 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.010 Scientific and technical reports. (b) For DoD, the Defense Technical Information Center is...

48 CFR 235.010 - Scientific and technical reports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... reports. 235.010 Section 235.010 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.010 Scientific and technical reports. (b) For DoD, the Defense Technical Information Center is...

48 CFR 235.010 - Scientific and technical reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... reports. 235.010 Section 235.010 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.010 Scientific and technical reports. (b) For DoD, the Defense Technical Information Center is...

48 CFR 235.010 - Scientific and technical reports.

Code of Federal Regulations, 2011 CFR

2011-10-01

... reports. 235.010 Section 235.010 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.010 Scientific and technical reports. (b) For DoD, the Defense Technical Information Center is...

Dacarbazine inhibits proliferation of melanoma FEMX-1 cells by up-regulating expression of miRNA-200.

PubMed

Chen, Y-N

2017-03-01

Melanoma is a highly aggressive tumour, and treatment efficacy depends on the stage of the tumour. Early stage cutaneous melanoma is efficiently treated by surgical excision. In contrast, late-stage melanoma requires chemotherapy with dacarbazine (DTIC). Unfortunately, advanced melanoma can often be resistant to DTIC. The mechanisms of anti-melanoma effects of DTIC are still poorly understood, which hinders development of more potent therapies. In this study, we examined the effects of DTIC on growth inhibition of FEMX-1 melanoma cell line, expression of apoptosis-related proteins, and expression of micro (mi)RNA-200 (miRNA-200a, miRNA-200b, miRNA-200c, and miRNA-141). DTIC was used at 50 (low dose) or 100 (high dose) mg/ml. Cell growth inhibition was documented by MTT assay. Cell apoptosis was quantified by propidium iodide staining and caspase 3-8 activity assay. Expression of apoptosis-related proteins Bim, Bak, BAX, and Bad were documented by Western blot analysis, while expression of miRNA-200 by PCR. DTIC dose-dependently inhibited growth of FEMX-1 melanoma cell line, induced cell apoptosis, modulated the levels of apoptosis-related proteins, and up-regulated expression of miRNA-200 family members. DTIC inhibits the growth of melanoma cells by up-regulating expression of miRNA-200.

A Medical Research and Evaluation Facility (MREF) and Studies Supporting the Medical Chemical Defense Program on Task 89-03: Test Up to 20 Candidate Topical Protectants

DTIC Science & Technology

1992-02-01

Snider, B.S., O.A.B.T. Date Study Supervisor I (.’ ’Quali tycsra-e Unit Date Health and Enviror snt Group . ... NTIS C7ŕ,1 DTIC IAtj U r, iv1: cu. 1v...the Federal Animal Welfare Act. Battelle’s statement of I] assurance regarding the Department of Health and Human Services policy on 4g I ] 1 humane...care of laboratory animals was accepted by the Office of Protection from Research Risks, National Institutes of Health , on August 27, 1973. Animals at

32 CFR 203.17 - Technical assistance provider reporting requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Technical assistance provider reporting requirements. 203.17 Section 203.17 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY... technical assistance provider shall submit progress reports, financial status reports, materials prepared...

32 CFR 203.17 - Technical assistance provider reporting requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Technical assistance provider reporting requirements. 203.17 Section 203.17 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY... technical assistance provider shall submit progress reports, financial status reports, materials prepared...

32 CFR 203.17 - Technical assistance provider reporting requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Technical assistance provider reporting requirements. 203.17 Section 203.17 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY... technical assistance provider shall submit progress reports, financial status reports, materials prepared...

32 CFR 203.17 - Technical assistance provider reporting requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Technical assistance provider reporting requirements. 203.17 Section 203.17 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY... technical assistance provider shall submit progress reports, financial status reports, materials prepared...

32 CFR 203.17 - Technical assistance provider reporting requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Technical assistance provider reporting requirements. 203.17 Section 203.17 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY... technical assistance provider shall submit progress reports, financial status reports, materials prepared...

32 CFR 117.53 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

...,” (available at http://www.dtic.mil/whs/directives/corres/pdf/520507p.pdf). Classified contract. As defined in... Military and Associated Terms” (available at http://www.dtic.mil/doctrine/new_pubs/jp1_02.pdf). Company. As..., “Joint Communication System” (available at http://www.dtic.mil/doctrine/new_pubs/jp6_0.pdf). Contractor...

32 CFR 117.55 - Responsibilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

...))” (available at http://www.dtic.mil/whs/directives/corres/pdf/514301p.pdf) and DoD Instruction 5220.22, “National Industrial Security Program” (see http://www.dtic.mil/whs/directives/corres/pdf/522022p.pdf): (1...://www.dtic.mil/whs/directives/corres/pdf/522022p.pdf). (1) Make FOCI determinations on a case-by-case...

32 CFR 108.4 - Policy.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/100013p.pdf. (2) Non... Internet at http://www.dtic.mil/whs/directives/corres/pdf/605501p.pdf. (3) Any health care services...://www.dtic.mil/whs/directives/corres/pdf/302041p.pdf. (h) Emergency Health Care. The Secretaries of the...

Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma.

PubMed

Yang, Chunhua; Cao, Hang; Liu, Ning; Xu, Kai; Ding, Meng; Mao, Li-Jun

2016-01-01

Conditionally replicating adenoviruses have emerged as novel therapeutic agents for cancer. This study aimed to evaluate synergistic antitumor activity of replication-competent adenovirus armed with interleukin (IL)-18 (ZD55-IL-18) and dacarbazine (DTIC) against melanoma. Melanoma A375 cells or nude mouse tumor xenografts were treated with ZD55-IL-18 alone or together with DTIC. The results showed that ZD55-IL-18 competently replicated in A375 cells and expressed IL-18, and these were not affected by DTIC. ZD55-IL-18 enhanced the cytotoxicity of DTIC accompanied by increased apoptosis. Moreover, ZD55-IL-18 and DTIC synergistically inhibited the growth but promoted the apoptosis of A375 xenografts and inhibited vascular endothelial growth factor expression and lung metastasis in xenografts of nude mice. In conclusion, this is the first study to show synergistic anticancer activity of ZD55-IL-18 and DTIC for malignant melanoma. Our results provide evidence that chemo-gene-viro therapeutic approach has greater potential for malignant cancers than conventional chemotherapy or gene therapy.

Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma

PubMed Central

Yang, Chunhua; Cao, Hang; Liu, Ning; Xu, Kai; Ding, Meng; Mao, Li-jun

2016-01-01

Conditionally replicating adenoviruses have emerged as novel therapeutic agents for cancer. This study aimed to evaluate synergistic antitumor activity of replication-competent adenovirus armed with interleukin (IL)-18 (ZD55-IL-18) and dacarbazine (DTIC) against melanoma. Melanoma A375 cells or nude mouse tumor xenografts were treated with ZD55-IL-18 alone or together with DTIC. The results showed that ZD55-IL-18 competently replicated in A375 cells and expressed IL-18, and these were not affected by DTIC. ZD55-IL-18 enhanced the cytotoxicity of DTIC accompanied by increased apoptosis. Moreover, ZD55-IL-18 and DTIC synergistically inhibited the growth but promoted the apoptosis of A375 xenografts and inhibited vascular endothelial growth factor expression and lung metastasis in xenografts of nude mice. In conclusion, this is the first study to show synergistic anticancer activity of ZD55-IL-18 and DTIC for malignant melanoma. Our results provide evidence that chemo-gene-viro therapeutic approach has greater potential for malignant cancers than conventional chemotherapy or gene therapy. PMID:27895465

32 CFR 701.38 - Technical data.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 5 2011-07-01 2011-07-01 false Technical data. 701.38 Section 701.38 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND... DOCUMENTS AFFECTING THE PUBLIC FOIA Definitions and Terms § 701.38 Technical data. Recorded information...

32 CFR 701.38 - Technical data.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Technical data. 701.38 Section 701.38 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND... DOCUMENTS AFFECTING THE PUBLIC FOIA Definitions and Terms § 701.38 Technical data. Recorded information...

Large randomized study of thymosin alpha 1, interferon alfa, or both in combination with dacarbazine in patients with metastatic melanoma.

PubMed

Maio, Michele; Mackiewicz, Andrzej; Testori, Alessandro; Trefzer, Uwe; Ferraresi, Virginia; Jassem, Jacek; Garbe, Claus; Lesimple, Thierry; Guillot, Bernard; Gascon, Pere; Gilde, Katalin; Camerini, Roberto; Cognetti, Francesco

2010-04-01

Thymosin alpha 1 (Talpha1) is an immunomodulatory polypeptide that enhances effector T-cell responses. In this large randomized study, we evaluated the efficacy and safety of combining Talpha1 with dacarbazine (DTIC) and interferon alfa (IFN-alpha) in patients with metastatic melanoma. Four hundred eighty-eight patients were randomly assigned to five treatment groups: DTIC+IFN-alpha+Talpha1 (1.6 mg); DTIC+IFN-alpha+Talpha1 (3.2 mg); DTIC+IFN-alpha+Talpha1 (6.4 mg); DTIC+Talpha1 (3.2 mg); DTIC+IFN-alpha (control group). The primary end point was best overall response at study end (12 months). Secondary end points included duration of response, overall survival (OS), and progression-free survival (PFS). Patients were observed for up to 24 months. Ten and 12 tumor responses were observed in the DTIC+IFN-alpha+Talpha1 (3.2 mg) and DTIC+Talpha1 (3.2 mg) groups, respectively, versus four in the control group, which was sufficient to reject the null hypothesis that P(0) < or = .05 (expected response rate of standard therapy) in these two arms. Duration of response ranged from 1.9 to 23.2 months in patients given Talpha1 and from 4.4 to 8.4 months in the control group. Median OS was 9.4 months in patients given Talpha1 versus 6.6 months in the control group (hazard ratio = 0.80; 9% CI, 0.63 to 1.02; P = .08). An increase in PFS was observed in patients given Talpha1 versus the control group (hazard ratio = 0.80; 95% CI, 0.63 to 1.01; P = .06). Addition of Talpha1 to DTIC and IFN-alpha did not lead to any additional toxicity. These results suggest Talpha1 has activity in patients with metastatic melanoma and provide rationale for further clinical evaluation of this agent.

32 CFR 37.1030 - What information must I report to the Defense Technical Information Center?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false What information must I report to the Defense Technical Information Center? 37.1030 Section 37.1030 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Executing the Award Reporting Information About the...

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Tribology of Ceramics. Report of the Committee on Tribology of Ceramics.

DTIC Science & Technology

1988-01-01

lt, Mat Iri t I S ,ne,i’-ch So ijet, and a Fe 1 low of the Ai’ h’ c P "lc; i". ...oi .... It S H 1- .S deHt11e in chemical engineering is from Vi...Committee on Tribology of Ceramics NATIONAL MATERIALS ADVISORY BOARD Commission on Engineering and Technical Systems National Research Council DTIC...the councils ot he National Academy of Sciences, the National Academy of Engineering , and the Institute Medicine. The members of the committee

Micro-Computer Network Architecture for Range Instrumentation Applications - Volume 1

DTIC Science & Technology

1991-12-18

AD-A247 836 MTI-R89-006-28 Micro-Computer Network Architecture for Range Instrumentation Applications Volume 1 Mitchell R. Belzer DTIC Yong M . Cho... M . Belzer, Y. Cho, J. Han 13a. TYPE OF REPORT 13b. TIME COVERED 14. DATE OF REPORT (Year, Month, Day) 15. PAGE COUNT Final Technical FROM 09SeDQ89...SpecialI I , 1 . . r l n l m s n u m mt l ~ i m I n : t l l l Contents page cover page ....................................................... 1 Report

Whither Ballistic Missile Defense?

DTIC Science & Technology

1992-11-30

Conference on Technical Marketing 2000: Opportunities and Strategies for a Changing World) I intend to discuss the prospects for SDI in a changing...Technical Marketing 2000: Opportunities and Strategies for a Changing World) Descriptors, Keywords: Cooper Speech Ballistic Missile Defense...WHITHER BALLISTIC MISSILE DEFENSE? BY AMBASSADOR HENRY F. COOPER NOVEMBER 30,1992 TECHNICAL MARKETING SOCIETY OF AMERICA WASHINGTON, DC

32 CFR 37.1040 - When and how do I report information required by § 37.1035?

Code of Federal Regulations, 2011 CFR

2011-07-01

... the central point for reporting to the DTIC must be: (a) Submitted by the dates that your central point establishes (which is consistent with the schedule DTIC specifies to DoD Components). (b) In the format that your central point provides (which is consistent with the format that the DTIC specifies to...

32 CFR 37.1040 - When and how do I report information required by § 37.1035?

Code of Federal Regulations, 2010 CFR

2010-07-01

... the central point for reporting to the DTIC must be: (a) Submitted by the dates that your central point establishes (which is consistent with the schedule DTIC specifies to DoD Components). (b) In the format that your central point provides (which is consistent with the format that the DTIC specifies to...

32 CFR 37.1040 - When and how do I report information required by § 37.1035?

Code of Federal Regulations, 2014 CFR

2014-07-01

... the central point for reporting to the DTIC must be: (a) Submitted by the dates that your central point establishes (which is consistent with the schedule DTIC specifies to DoD Components). (b) In the format that your central point provides (which is consistent with the format that the DTIC specifies to...

32 CFR 37.1040 - When and how do I report information required by § 37.1035?

Code of Federal Regulations, 2013 CFR

2013-07-01

... the central point for reporting to the DTIC must be: (a) Submitted by the dates that your central point establishes (which is consistent with the schedule DTIC specifies to DoD Components). (b) In the format that your central point provides (which is consistent with the format that the DTIC specifies to...

Dosage and cycle effects of dacarbazine (DTIC) and fotemustine on O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells.

PubMed Central

Lee, S. M.; Thatcher, N.; Dougal, M.; Margison, G. P.

1993-01-01

There is increasing experimental evidence to suggest that endogenous expression of O6-alkylguanine-DNA-alkyltransferase (ATase) is a major factor in cellular resistance to certain chemotherapeutic agents including dacarbazine (DTIC). We have recently shown wide interindividual variation in the depletion and subsequent regeneration of ATase in peripheral blood mononuclear cells (PMCs) following DTIC and this has now been extended to ascertain whether or not depletion is related to dosage of DTIC used and repeated treatment cycles of chemotherapy. ATase levels were measured in three groups of 25 patients (pts) up to 24 h after receiving DTIC at 400 mg m-2, 500 mg m-2 or 800 mg m-2. Each group also received fotemustine (100 mg m-2), 4 h after DTIC. The lowest extent of ATase depletion (highest nadir ATase) was seen in patients receiving 400 mg m-2. The mean nadir ATase, expressed as a percentage of pre-treatment ATase, was respectively 56.3%, 26.4% and 23.9% for 400 mg m-2, 500 mg m-2 and 800 mg m-2. The median nadir of ATase activity for pts receiving 800 mg m-2 pts was at 4-6 h and for pts given lower doses it was at 2-3 h. In addition, repeated measures analysis of variance of observations before chemotherapy, then at 2, 3, 4, 6 and 18 h after chemotherapy provides some evidence that ATase was depleted to a lesser extent after cycle 1 than after subsequent cycles (P = 0.025). It also provides evidence that the change in ATase activity over time varied with dose and cycle. The findings can be interpreted on the basis of a dosage-dependent metabolism of DTIC to an agent capable of methylation of DNA and subsequent depletion of PMC ATase: with higher DTIC doses, the extent of ATase depletion may be limited by the pharmacokinetics of DTIC metabolism. PMC ATase was measured in another group of 8 pts at various times after receiving only fotemustine (100 mg m-2) and in contrast to DTIC, no ATase depletion was seen suggesting that insufficient concentrations of fotemustine and/or its metabolites were available to react with DNA to produce a depletion of PMC ATase activity. PMID:8431354

32 CFR 28.300 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Professional and technical services. 28.300 Section 28.300 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS NEW RESTRICTIONS ON LOBBYING Activities by Other Than Own Employees § 28.300...

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32 CFR 203.12 - Technical assistance for public participation provider qualifications.

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2010-07-01

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32 CFR 286.30 - Collection of fees and fee rates for technical data.

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2014-07-01

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Acid Ceramidase Expression Modulates the Sensitivity of A375 Melanoma Cells to Dacarbazine*

PubMed Central

Bedia, Carmen; Casas, Josefina; Andrieu-Abadie, Nathalie; Fabriàs, Gemma; Levade, Thierry

2011-01-01

Dacarbazine (DTIC) is the treatment of choice for metastatic melanoma, but its response in patients remains very poor. Ceramide has been shown to be a death effector and to play an important role in regulating cancer cell growth upon chemotherapy. Among ceramidases, the enzymes that catabolize ceramide, acid ceramidase (aCDase) has been implicated in cancer progression. Here we show that DTIC elicits a time- and dose-dependent decrease of aCDase activity and an increase of intracellular ceramide levels in human A375 melanoma cells. The loss of enzyme activity occurred as a consequence of reactive oxygen species-dependent activation of cathepsin B-mediated degradation of aCDase. These events preceded autophagic features and loss of cell viability. Down-regulation of acid but not neutral or alkaline ceramidase 2 resulted in elevated levels of ceramide and sensitization to the toxic effects of DTIC. Conversely, inducible overexpression of acid but not neutral ceramidase reduced ceramide levels and conferred resistance to DTIC. In conclusion, we report that increased levels of ceramide, due to enhanced degradation of aCDase, are in part responsible for the cell death effects of DTIC. These results suggest that down-regulation of aCDase alone or in combination with DTIC may represent a useful tool in the treatment of metastatic melanoma. PMID:21700700

Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine.

PubMed

Bedia, Carmen; Casas, Josefina; Andrieu-Abadie, Nathalie; Fabriàs, Gemma; Levade, Thierry

2011-08-12

Dacarbazine (DTIC) is the treatment of choice for metastatic melanoma, but its response in patients remains very poor. Ceramide has been shown to be a death effector and to play an important role in regulating cancer cell growth upon chemotherapy. Among ceramidases, the enzymes that catabolize ceramide, acid ceramidase (aCDase) has been implicated in cancer progression. Here we show that DTIC elicits a time- and dose-dependent decrease of aCDase activity and an increase of intracellular ceramide levels in human A375 melanoma cells. The loss of enzyme activity occurred as a consequence of reactive oxygen species-dependent activation of cathepsin B-mediated degradation of aCDase. These events preceded autophagic features and loss of cell viability. Down-regulation of acid but not neutral or alkaline ceramidase 2 resulted in elevated levels of ceramide and sensitization to the toxic effects of DTIC. Conversely, inducible overexpression of acid but not neutral ceramidase reduced ceramide levels and conferred resistance to DTIC. In conclusion, we report that increased levels of ceramide, due to enhanced degradation of aCDase, are in part responsible for the cell death effects of DTIC. These results suggest that down-regulation of aCDase alone or in combination with DTIC may represent a useful tool in the treatment of metastatic melanoma.

In-vitro and in-vivo inhibition of melanoma growth and metastasis by the drug combination of celecoxib and dacarbazine.

PubMed

Sadhu, Satya S; Wang, Shenggang; Averineni, Ranjith K; Seefeldt, Teresa; Yang, Yang; Guan, Xiangming

2016-12-01

Celecoxib has been found to be effective in cancer prevention and treatment. Its combination with other chemotherapeutic agents was reported to produce synergistic/additive effects on various cancers. Dacarbazine (DTIC) is one of the most commonly used drugs in the treatment of metastatic melanoma. This investigation aimed to determine the in-vitro and in-vivo effects of the drug combination of celecoxib and DTIC on melanoma growth and metastasis. Melanoma cells B16-F10 and SK-MEL-28, and female C57BL/6 mice were used for the study. Our in-vitro data showed that significant synergistic effects were obtained when celecoxib was used together with various concentrations of DTIC. A study with B16-F10 cells using flow cytometry analysis showed that the drug combination induced significantly more apoptosis than each drug used individually. Our in-vivo results showed that the drug combination was much more effective than each drug used alone for the inhibition of both melanoma growth and metastasis in the B16-F10+C57BL/6 mouse models. For melanoma growth, the median survival rates for phosphate-buffered saline (PBS) (control), celecoxib (30 mg/kg), DTIC-1 (10 mg/kg), DTIC-2 (positive control, 50 mg/kg), and the drug combination (DTIC 10 mg/kg+celecoxib 30 mg/kg) were 6, 6.5, 7.5, 7.5, and 9 days, respectively. For melanoma metastasis, the average number of metastatic tumors in murine lungs was 53.7±10.7, 31.8±18.6, 21.2±21.7, 7.0±9.0, and 0.8±2.0 for PBS, DTIC-1, celecoxib, the drug combination, and DTIC-2. Our results warrant further investigation of the combination as an effective treatment for melanoma patients.

Randomized phase 2/3 trial of CpG oligodeoxynucleotide PF-3512676 alone or with dacarbazine for patients with unresectable stage III and IV melanoma.

PubMed

Weber, Jeffrey S; Zarour, Hassan; Redman, Bruce; Trefzer, Uwe; O'Day, Steven; van den Eertwegh, Alfons J M; Marshall, Ernest; Wagner, Stefan

2009-09-01

The primary objective of this phase 2 study was to assess the objective response rate (complete response [CR] + partial responses [PR]), by Response Evaluation Criteria in Solid Tumors, of PF-3512676, a CpG oligodeoxynucleotide, alone in 2 doses or in combination with dacarbazine (DTIC) in patients with unresectable stage IIIB/C or stage IV malignant melanoma, with the aim of selecting an arm to take forward to a phase 3 portion of the study. A total of 184 patients were randomized to 1 of 4 treatments: PF-3512676 10 mg (low dose), at 40 mg (high dose), 40 mg plus DTIC (850 mg/m(2)), or DTIC (850 mg/m(2)) alone. Patients received PF-3512676 subcutaneously weekly in a 3-week cycle and received DTIC intravenously on the first week of the cycle. The objective response rate (PR or CR, confirmed or unconfirmed) in the 40 mg + DTIC arm was 16% (7 patients) compared with 8% (3 patients) with DTIC alone. One (2%) patient in the 10-mg and 0 patients in the 40-mg arms achieved an objective response. Best response of CR or PR or stable disease (SD), with no minimum duration defined for SD, was achieved by 15 (33%) patients in the 40 mg + DTIC arm, 15 (38%) patients in the DTIC-only arm, 8 (17%) patients in the 10-mg arm, and 9 (20%) patients in the 40-mg arm. The most frequently reported adverse events were classified as local injection site reactions or systemic flu-like symptoms, specifically fatigue, rigors, and pyrexia. PF-3512676 at the doses used was generally well tolerated. The modest objective response rates observed in all arms did not warrant continuation to the phase 3 portion of the study.

Combination of CCNU and DTIC chemotherapy for treatment of resistant lymphoma in dogs.

PubMed

Flory, A B; Rassnick, K M; Al-Sarraf, R; Bailey, D B; Balkman, C E; Kiselow, M A; Autio, K

2008-01-01

Pleotropic-glycoprotein (P-gp)-mediated resistance is the usual cause of relapse in dogs with lymphoma. 1-(2-chloroethyl)3-cyclohexyl-1-nitrosurea (CCNU) and 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) are alkylating agents that are not affected by P-gp and lack cross-resistance to each other. A combination protocol offers the advantage of improved summation dose and synergistic activity. A combination of CCNU and DTIC that is well tolerated can be used to treat dogs with lymphoma that developed resistance or failed to respond to previously administered chemotherapy. Fifty-seven dogs with lymphoma that were resistant to treatment with standard chemotherapy (L-CHOP; L-asparaginase, cyclophosphamide, doxorubicin, vincristine, prednisone). Prospective phase I and II trials were performed. CCNU was given PO immediately before a 5-h IV infusion of DTIC. Concurrent antiemetics and prophylactic antibiotics were used. Treatments were administered every 4 weeks. Based on the results of 8 dogs in the phase I study, CCNU at 40 mg/m(2) PO combined with DTIC at 600 mg/m(2) IV was used to treat 57 dogs with resistant lymphoma. Thirteen (23%) dogs had a complete response (CR) for a median of 83 days and 7 (12%) had a partial response for a median of 25 days. The median L-CHOP CR duration of the dogs that did not respond to CCNU-DTIC was significantly longer than that of the dogs that did achieve remission with CCNU-DTIC (225 days versus 92 days, P= .02). The principal toxic event was neutropenia; the median neutrophil count 7 days after treatment was 1,275 cells/microL. Increases in alanine transaminase activity, possibly associated with hepatotoxicity, were detected in 7 dogs. A combination of CCNU and DTIC can be an effective option to rescue dogs with resistant lymphoma.

Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG.

PubMed

Schadendorf, D; Ugurel, S; Schuler-Thurner, B; Nestle, F O; Enk, A; Bröcker, E-B; Grabbe, S; Rittgen, W; Edler, L; Sucker, A; Zimpfer-Rechner, C; Berger, T; Kamarashev, J; Burg, G; Jonuleit, H; Tüttenberg, A; Becker, J C; Keikavoussi, P; Kämpgen, E; Schuler, G

2006-04-01

This randomized phase III trial was designed to demonstrate the superiority of autologous peptide-loaded dendritic cell (DC) vaccination over standard dacarbazine (DTIC) chemotherapy in stage IV melanoma patients. DTIC 850 mg/m2 intravenously was applied in 4-week intervals. DC vaccines loaded with MHC class I and II-restricted peptides were applied subcutaneously at 2-week intervals for the first five vaccinations and every 4 weeks thereafter. The primary study end point was objective response (OR); secondary end points were toxicity, overall (OS) and progression-free survival (PFS). At the time of the first interim analysis 55 patients had been enrolled into the DTIC and 53 into the DC-arm (ITT). OR was low (DTIC: 5.5%, DC: 3.8%), but not significantly different in the two arms. The Data Safety & Monitoring Board recommended closure of the study. Unscheduled subset analyses revealed that patients with normal serum LDH and/or stage M1a/b survived longer in both arms than those with elevated serum LDH and/or stage M1c. Only in the DC-arm did those patients with (i) an initial unimpaired general health status (Karnofsky = 100) or (ii) an HLA-A2+/HLA-B44- haplotype survive significantly longer than patients with a Karnofsky index <100 (P = 0.007 versus P = 0.057 in the DTIC-arm) or other HLA haplotypes (P = 0.04 versus P = 0.57 in DTIC-treated patients). DC vaccination could not be demonstrated to be more effective than DTIC chemotherapy in stage IV melanoma patients. The observed association of overall performance status and HLA haplotype with overall survival for patients treated by DC vaccination should be tested in future trials employing DC vaccines.

The efficacy of combination therapy with oncolytic herpes simplex virus HF10 and dacarbazine in a mouse melanoma model.

PubMed

Tanaka, Rui; Goshima, Fumi; Esaki, Shinichi; Sato, Yoshitaka; Murata, Takayuki; Nishiyama, Yukihiro; Watanabe, Daisuke; Kimura, Hiroshi

2017-01-01

Advanced melanoma has long been treated with chemotherapy using cytotoxic agents like dacarbazine (DTIC), but overall survival rates with these drugs have been generally low. Recently, immunoregulatory monoclonal antibodies and molecularly targeted therapy with a BRAF inhibitor and/or a MEK inhibitor, have been used to treat malignant melanoma and have improved the survival rate of patients with advanced melanoma. However, high prices of these drugs are problematic. In this study, we evaluated the oncolytic efficacy of HF10, an attenuated, replication-competent HSV, with DTIC in immunocompetent mice model of malignant melanoma. For in vitro studies, cytotoxicity assays were conducted in clone M3 mouse melanoma cells. For the in vivo studies, subcutaneous melanoma models were prepared in DBA/2 mice with clone M3 cells, and then HF10 was intratumorally inoculated with/without intraperitoneal DTIC injection. The efficacy of the therapies was evaluated by survival, growth of subcutaneous tumor, and histopathological and immunological analyses. Both HF10 infection and DTIC treatment showed cytotoxic effects in melanoma cells, but combination treatment with HF10 and DTIC showed a rapid and strong cytotoxic effect compared with monotherapy. In the subcutaneous melanoma model, intratumoral HF10 inoculation significantly inhibited tumor growth. HF10 also inhibited the growth of non-inoculated contralateral tumors when it was injected into the ipsilateral tumors of mice. In histologic and immunohistochemical analysis, tumor lysis and inflammatory cell infiltration were observed after intratumoral HF10 inoculation. When mice were treated with HF10 and DTIC, the combination therapy induced a robust systemic anti-tumor immune response and prolonged survival. IFN-γ secretion from splenocytes of the HF10-DTIC combination therapy group showed more IFN-γ secretion than did the other groups. These data showed the efficacy of HF10 and DTIC combination therapy in a mouse melanoma model.

The efficacy of combination therapy with oncolytic herpes simplex virus HF10 and dacarbazine in a mouse melanoma model

PubMed Central

Tanaka, Rui; Goshima, Fumi; Esaki, Shinichi; Sato, Yoshitaka; Murata, Takayuki; Nishiyama, Yukihiro; Watanabe, Daisuke; Kimura, Hiroshi

2017-01-01

Advanced melanoma has long been treated with chemotherapy using cytotoxic agents like dacarbazine (DTIC), but overall survival rates with these drugs have been generally low. Recently, immunoregulatory monoclonal antibodies and molecularly targeted therapy with a BRAF inhibitor and/or a MEK inhibitor, have been used to treat malignant melanoma and have improved the survival rate of patients with advanced melanoma. However, high prices of these drugs are problematic. In this study, we evaluated the oncolytic efficacy of HF10, an attenuated, replication-competent HSV, with DTIC in immunocompetent mice model of malignant melanoma. For in vitro studies, cytotoxicity assays were conducted in clone M3 mouse melanoma cells. For the in vivo studies, subcutaneous melanoma models were prepared in DBA/2 mice with clone M3 cells, and then HF10 was intratumorally inoculated with/without intraperitoneal DTIC injection. The efficacy of the therapies was evaluated by survival, growth of subcutaneous tumor, and histopathological and immunological analyses. Both HF10 infection and DTIC treatment showed cytotoxic effects in melanoma cells, but combination treatment with HF10 and DTIC showed a rapid and strong cytotoxic effect compared with monotherapy. In the subcutaneous melanoma model, intratumoral HF10 inoculation significantly inhibited tumor growth. HF10 also inhibited the growth of non-inoculated contralateral tumors when it was injected into the ipsilateral tumors of mice. In histologic and immunohistochemical analysis, tumor lysis and inflammatory cell infiltration were observed after intratumoral HF10 inoculation. When mice were treated with HF10 and DTIC, the combination therapy induced a robust systemic anti-tumor immune response and prolonged survival. IFN-γ secretion from splenocytes of the HF10-DTIC combination therapy group showed more IFN-γ secretion than did the other groups. These data showed the efficacy of HF10 and DTIC combination therapy in a mouse melanoma model. PMID:28861325

Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.

PubMed

Thangasamy, Thilakavathy; Sittadjody, Sivanandane; Limesand, Kirsten H; Burd, Randy

2008-01-01

Dacarbazine (DTIC) has been used for the treatment of melanoma for decades. However, monotherapy with this chemotherapeutic agent results only in moderate response rates. To improve tumor response to DTIC current clinical trials in melanoma focus on combining a novel targeted agent with chemotherapy. Here, we demonstrate that tyrosinase which is commonly overexpressed in melanoma activates the bioflavonoid quercetin (Qct) and promotes an ataxia telangiectasia mutated (ATM)-dependent DNA damage response. This response sensitizes melanoma cells that overexpress tyrosinase to DTIC. In DB-1 melanoma cells that overexpress tyrosinase (Tyr(+) cells), the threshold for phosphorylation of ATM and p53 at serine 15 was observed at a low dose of Qct (25 microM) when compared to the mock transfected pcDNA3 cells, which required a higher dose (75 microM). Both pcDNA3 and Tyr(+) DB-1 cells demonstrated similar increases in phosphorylation of p53 at other serine sites, but in the Tyr(+) cells, DNApk expression was found to be reduced compared to control cells, indicating a shift towards an ATM-mediated response. The DB-1 control cells were resistant to DTIC, but were sensitized to apoptosis with high dose Qct, while Tyr(+) cells were sensitized to DTIC with low or high dose Qct. Qct also sensitized SK Mel 5 (p53 wildtype) and 28 (p53 mutant) cells to DTIC. However, when SK Mel 5 cells were transiently transfected with tyrosinase and treated with Qct plus DTIC, SK Mel 5 cells demonstrated a more than additive induction of apoptosis. Therefore, this study demonstrates that tyrosinase overexpression promotes an ATM-dependent p53 phosphorylation by Qct treatment and sensitizes melanoma cells to dacarbazine. In conclusion, these results suggest that Qct or Qct analogues may significantly improve DTIC response rates in tumors that express tyrosinase.

Tyrosinase Overexpression Promotes ATM-Dependent p53 Phosphorylation by Quercetin and Sensitizes Melanoma Cells to Dacarbazine

PubMed Central

Thangasamy, Thilakavathy; Sittadjody, Sivanandane; H. Limesand, Kirsten; Burd, Randy

2008-01-01

Dacarbazine (DTIC) has been used for the treatment of melanoma for decades. However, monotherapy with this chemotherapeutic agent results only in moderate response rates. To improve tumor response to DTIC current clinical trials in melanoma focus on combining a novel targeted agent with chemotherapy. Here, we demonstrate that tyrosinase which is commonly overexpressed in melanoma activates the bioflavonoid quercetin (Qct) and promotes an ataxia telangiectasia mutated (ATM)-dependent DNA damage response. This response sensitizes melanoma cells that overexpress tyrosinase to DTIC. In DB-1 melanoma cells that overexpress tyrosinase (Tyr cells), the threshold for phosphorylation of ATM and p53 at serine 15 was observed at a low dose of Qct (25 μM) when compared to the mock transfected pcDNA3 cells, which required a higher dose (75 μM). Both pcDNA3 and Tyr DB-1 cells demonstrated similar increases in phosphorylation of p53 at other serine sites, but in the Tyr cells, DNApk expression was found to be reduced compared to control cells, indicating a shift towards an ATM-mediated response. The DB-1 control cells were resistant to DTIC, but were sensitized to apoptosis with high dose Qct, while Tyr cells were sensitized to DTIC with low or high dose Qct. Qct also sensitized SK Mel 5 (p53 wildtype) and 28 (p53 mutant) cells to DTIC. However, when SK Mel 5 cells were transiently transfected with tyrosinase and treated with Qct plus DTIC, SK Mel 5 cells demonstrated a more than additive induction of apoptosis. Therefore, this study demonstrates that tyrosinase overexpression promotes an ATM-dependent p53 phosphorylation by Qct treatment and sensitizes melanoma cells to dacarbazine. In conclusion, these results suggest that Qct or Qct analogues may significantly improve DTIC response rates in tumors that express tyrosinase. PMID:18791269

22 CFR 126.17 - Exemption pursuant to the Defense Trade Cooperation Treaty between the United States and the...

Code of Federal Regulations, 2013 CFR

2013-04-01

...; (ii) Technical data (including data packages, technical papers, manuals, presentations, specifications... person who receives defense articles, including technical data, but who does not have access to such... (other than technical data) shall be individually labeled with the appropriate identification detailed in...

22 CFR 126.16 - Exemption pursuant to the Defense Trade Cooperation Treaty between the United States and Australia.

Code of Federal Regulations, 2014 CFR

2014-04-01

... section; (ii) Technical data (including data packages, technical papers, manuals, presentations..., defense articles, including technical data, for the sole purpose of effecting onward movement to members... (other than technical data) shall be individually labeled with the appropriate identification detailed in...

2017 Workplace and Gender Relations Survey of Reserve Component Members: Overview Report

DTIC Science & Technology

2018-04-30

2017 Workplace and Gender Relations Survey of Reserve Component Members DoD Overview Report Additional copies of this report may be...www.dtic.mil/dtic/order.html Ask for report by DTIC# OPA Report No. 2018-026 April 2018 2017 Workplace and Gender Relations Survey of...OPA) 4800 Mark Center Drive, Suite 06E22, Alexandria, VA 22350-4000 OPA 2017 Workplace and Gender Relations Survey of Reserve Component Members ii

2017 Workplace and Gender Relations Survey of Reserve Component Members: Tabulations of Responses

DTIC Science & Technology

2018-04-30

2017 Workplace and Gender Relations Survey of Reserve Component Members Tabulations of Responses Additional copies of this report may be...http://www.dtic.mil/dtic/order.html Ask for report by DTIC# OPA Report No. 2018-012 April 2018 2017 Workplace and Gender Relations Survey of...Alexandria, VA 22350-4000 2017 Workplace and Gender Relations Survey of Reserve Component Members ii OPA Acknowledgments The Office of People Analytics

22 CFR 125.4 - Exemptions of general applicability.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., except detailed design, development, production or manufacturing information; (7) Technical data..., production, or manufacture of any defense article; (4) Copies of technical data, including classified..., development, production, or manufacture of any defense article; (9) Technical data, including classified...

HP-41CV Flight Performance Advisory System (FPAS) for the E-2C, E-2B, and C-2A Aircraft

DTIC Science & Technology

1982-06-01

NPS67-82- 003 NAVAL POSTGRADUATE SCHOOL Monterey, California DTIC HP-41CV FLIGHT PERFORMANCE ADVISORY SYSTEM (FPAS) FOR THE E-2C, E-2B, AND C-2A...A’P-𔃻"’f .00 ____________ 4. TITLE9 (and Subtil) SL TYPE OF REPORT & PERIOD COVERED H1P-41CV FLIGHT PERFORMANCE ADVISORY SYSTEM (FPAS) TECHNICAL REPORT...complement the original design of a Flight Performance Advisory System (FPAS) for the E-2C aircraft. The original design fulfilled the requirements of AE 3001

Comparison of Retention Patterns for Army National Guard and Army Reserve Units Participating in National Training Center, Reforger and Blazing Trails Exercises

DTIC Science & Technology

1990-01-01

Department of the Army RAND Corp. Accesion Fo, NTIS CRA&I Technical review by DTIC ! A6 0Undnno s: ced 0 David K. Home tl IC I Robert W. Tinney By Dist...changes to the Sixth Quadrennial Review of Military Compensation. viii COMPARISON OF RETENTION PATTERNS FOR NATIONAL GUARD AND ARMY RESERVE UNITS...duty time-- movies , volleyball, and time to go to the PX at Big Bear. Because of the work schedule, the soldiers did not have any free time in the

Application of homology modeling to generate CYP1A1 mutants with enhanced activation of the cancer chemotherapeutic prodrug dacarbazine.

PubMed

Lewis, Benjamin C; Mackenzie, Peter I; Miners, John O

2011-11-01

The chemotherapeutic prodrug dacarbazine (DTIC) has limited efficacy in human malignancies and exhibits numerous adverse effects that arise from systemic exposure to the cytotoxic metabolite. DTIC is activated by CYP1A1 and CYP1A2 catalyzed N-demethylation. However, structural features of these enzymes that confer DTIC N-demethylation have not been characterized. A validated homology model of CYP1A1 was employed to elucidate structure-activity relationships and to engineer CYP1A1 enzymes with altered DTIC activation. In silico docking demonstrated that DTIC orientates proximally to Ser122, Phe123, Asp313, Ala317, Ile386, Tyr259, and Leu496 of human CYP1A1. The site of metabolism is positioned 5.6 Å from the heme iron at an angle of 105.3°. Binding in the active site is stabilized by H-bonding between Tyr259 and the N(2) position of the imidazole ring. Twenty-seven CYP1A1 mutants were generated and expressed in Escherichia coli in yields ranging from 9 to 225 pmol P450/mg. DTIC N-demethylation by the E161K, E256K, and I458V mutants exhibited Michaelis-Menten kinetics, with decreases in K(m) (183-249 μM) that doubled the catalytic efficiency (p < 0.05) relative to wild-type CYP1A1 (K(m), 408 ± 43 μM; V(max), 28 ± 4 pmol · min(-1) · pmol of P450(-1)). The generation of enzymes with catalytically enhanced DTIC activation highlights the potential use of mutant CYP1A1 proteins in P450-based gene-directed enzyme prodrug therapy for the treatment of metastatic malignant melanoma.

Meta-Analysis of the Safety and Efficacy of Interferon Combined With Dacarbazine Versus Dacarbazine Alone in Cutaneous Malignant Melanoma.

PubMed

Xin, Yong; Huang, Qian; Zhang, Pei; Yang, Ming; Hou, Xiao-Yang; Tang, Jian-Qin; Zhang, Long Zhen; Jiang, Guan

2016-04-01

The aim of this study was to compare the efficacy and safety of interferon (IFN) combined with dacarbazine (DTIC) (experimental group) versus DTIC alone (control group) in cutaneous malignant melanoma. After searching all available databases, eligible articles were identified and subjected to quality assessment. Meta-analysis was performed using RevMan 5.3; combined relative risk (RR) and 95% confidence intervals (95% CIs) were calculated for survival rates, response rates, and adverse events. Eight randomized controlled trials published between 1990 and 2014 involving 795 patients were included in the meta-analysis. Compared with DTIC alone, IFN combined with DTIC significantly increased the overall response rate (RR = 1.59, 95% CI 1.21-2.08, P = 0.0008),the complete response rate (RR = 3.30, 95% CI 1.89-5.76, P < 0.0001), 2-year survival (RR = 1.59, 95% CI 0.99-2.54, P = 0.050) grade ≥3 hematologic toxicity (RR = 2.30, 95% CI 1.32-4.02, P = 0.003), neurotoxicity (RR = 18.15, 95% CI 5.34-61.74, P < 0.00001), and flu-like symptoms (RR = 6.31, 95% CI 1.95-20.39, P = 0.002). The partial response rate, grade ≥3 nausea and vomiting, treatment-related, and 1- and 3-year survival were not significantly different between IFN combined with DTIC and DTIC alone. IFN combined with DTIC may moderately improve the complete response rate, but increases the incidence of adverse events and has no significant effect on 1- and 3-year survival in cutaneous malignant melanoma.

Meta-Analysis of the Safety and Efficacy of Interferon Combined With Dacarbazine Versus Dacarbazine Alone in Cutaneous Malignant Melanoma

PubMed Central

Xin, Yong; Huang, Qian; Zhang, Pei; Yang, Ming; Hou, Xiao-Yang; Tang, Jian-Qin; Zhang, Long Zhen; Jiang, Guan

2016-01-01

Abstract The aim of this study was to compare the efficacy and safety of interferon (IFN) combined with dacarbazine (DTIC) (experimental group) versus DTIC alone (control group) in cutaneous malignant melanoma. After searching all available databases, eligible articles were identified and subjected to quality assessment. Meta-analysis was performed using RevMan 5.3; combined relative risk (RR) and 95% confidence intervals (95% CIs) were calculated for survival rates, response rates, and adverse events. Eight randomized controlled trials published between 1990 and 2014 involving 795 patients were included in the meta-analysis. Compared with DTIC alone, IFN combined with DTIC significantly increased the overall response rate (RR = 1.59, 95% CI 1.21–2.08, P = 0.0008),the complete response rate (RR = 3.30, 95% CI 1.89–5.76, P < 0.0001), 2-year survival (RR = 1.59, 95% CI 0.99–2.54, P = 0.050) grade ≥3 hematologic toxicity (RR = 2.30, 95% CI 1.32–4.02, P = 0.003), neurotoxicity (RR = 18.15, 95% CI 5.34–61.74, P < 0.00001), and flu-like symptoms (RR = 6.31, 95% CI 1.95–20.39, P = 0.002). The partial response rate, grade ≥3 nausea and vomiting, treatment-related, and 1- and 3-year survival were not significantly different between IFN combined with DTIC and DTIC alone. IFN combined with DTIC may moderately improve the complete response rate, but increases the incidence of adverse events and has no significant effect on 1- and 3-year survival in cutaneous malignant melanoma. PMID:27100429

MGMT expression levels predict disease stabilisation, progression-free and overall survival in patients with advanced melanomas treated with DTIC.

PubMed

Busch, Christian; Geisler, Jürgen; Lillehaug, Johan R; Lønning, Per Eystein

2010-07-01

Metastatic melanoma responds poorly to systemic treatment. We report the results of a prospective single institution study evaluating O(6)-methylguanine-DNA methyltransferase (MGMT) status as a potential predictive and/or prognostic marker among patients treated with dacarbazine (DTIC) 800-1000 mg/m(2) monotherapy administered as a 3-weekly schedule for advanced malignant melanomas. The study was approved by the Regional Ethical Committee. Surgical biopsies from metastatic or loco-regional deposits obtained prior to DTIC treatment were snap-frozen immediately upon removal and stored in liquid nitrogen up to processing. Median time from enrolment to end of follow-up was 67 months. MGMT expression levels evaluated by qRT-PCR correlated significantly to DTIC benefit (CR/PR/SD; p=0.005), time to progression (TTP) (p=0.005) and overall survival (OS) (p=0.003). MGMT expression also correlated to Breslow thickness in the primary tumour (p=0.014). While MGMT promoter hypermethylation correlated to MGMT expression, MGMT promoter hypermethylation did not correlate to treatment benefit, TTP or OS, suggesting that other factors may be critical in determining MGMT expression levels in melanomas. In a Cox proportional regression analysis, serum lactate dehydrogenase (LDH, p<0.001), MGMT expression (p=0.022) and p16(INK4a) expression (p=0.037) independently predicted OS, while TTP correlated to DTIC benefit after 6 weeks only (p=0.001). Our data reveal MGMT expression levels to be associated with disease stabilisation and prognosis in patients receiving DTIC monotherapy for advanced melanoma. The role of MGMT expression as a predictor to DTIC sensitivity versus a general prognostic factor in advanced melanomas warrants further evaluation. Copyright 2010 Elsevier Ltd. All rights reserved.

A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naïve patients with advanced melanoma.

PubMed

Hersh, Evan M; O'Day, Steven J; Powderly, John; Khan, Khuda D; Pavlick, Anna C; Cranmer, Lee D; Samlowski, Wolfram E; Nichol, Geoffrey M; Yellin, Michael J; Weber, Jeffrey S

2011-06-01

Ipilimumab is a fully human, anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody that has demonstrated antitumor activity in advanced melanoma. We evaluated the safety and efficacy of ipilimumab alone and in combination with dacarbazine (DTIC) in patients with unresectable, metastatic melanoma. Chemotherapy-naïve patients were randomized in this multicenter, phase II study to receive ipilimumab at 3 mg/kg every 4 weeks for four doses either alone or with up to six 5-day courses of DTIC at 250 mg/m(2)/day. The primary efficacy endpoint was objective response rate. Seventy-two patients were treated per-protocol (ipilimumab plus DTIC, n = 35; ipilimumab, n = 37). The objective response rate was 14.3% (95% CI, 4.8-30.3) with ipilimumab plus DTIC and was 5.4% (95% CI, 0.7-18.2) with ipilimumab alone. At a median follow-up of 20.9 and 16.4 months for ipilimumab plus DTIC (n = 32) and ipilimumab alone (n = 32), respectively, median overall survival was 14.3 months (95% CI, 10.2-18.8) and 11.4 months (95% CI, 6.1-15.6); 12-month, 24-month, and 36-month survival rates were 62%, 24% and 20% for the ipilimumab plus DTIC group and were 45%, 21% and 9% for the ipilimumab alone group, respectively. Immune-related adverse events were, in general, medically manageable and occurred in 65.7% of patients in the combination group versus 53.8% in the monotherapy group, with 17.1% and 7.7% ≥grade 3, respectively. Ipilimumab therapy resulted in clinically meaningful responses in advanced melanoma patients, and the results support further investigations of ipilimumab in combination with DTIC.

Anti-melanoma activity of the 9.2.27PE immunotoxin in dacarbazine resistant cells.

PubMed

Risberg, Karianne; Fodstad, Oystein; Andersson, Yvonne

2010-04-01

We have earlier shown that the 9.2.27 Pseudomonas Exotoxin A (PE) immunotoxin (IT) efficiently kills melanoma cells through inhibition of protein synthesis followed by some morphologic and biochemical features of apoptosis, a different cell killing mechanism than the one caused by Dacarbazine (DTIC), a chemotherapeutic drug used to treat malignant melanoma. To examine whether induced DTIC resistance also is a determining factor for the effectiveness of 9.2.27PE IT, we developed a DTIC resistant subline, FEMX-200DR, from the DTIC sensitive cell line FEMX. The cell variants were treated with 9.2.27PE, an IT binding to the high molecular weight-melanoma associated antigen (HMW-MAA) expressed on most malignant melanoma cells. The IT was equally effective in killing the FEMX-200DR and the FEMX cells, and the cell death was primarily caused by inhibition of protein synthesis. The DNA repair enzyme and apoptotic marker PARP, a substrate of caspase-3, was inactivated, although we observed only a minor activation of caspase-3 and caspase-8, intracellular proteases involved in apoptosis. In addition to being DTIC resistant, the FEMX-200DR cells were also more resistant to apoptosis than the parent cells as a 3 times higher concentration of the apoptotic inducer Staurosporine was needed to obtain IC50. Furthermore, in early passage malignant melanoma cell lines established from lymph node metastases, the 9.2.27PE caused a time-dependent and dose-dependent decrease in cell viability independent of their DTIC sensitivity. These findings show that the 9.2.27PE IT efficiently can cause cell death in malignant melanoma cells independent of their level of resistance to apoptosis and DTIC.

Impact of Therapy Sequence with Alkylating Agents and MGMT Status in Patients with Advanced Neuroendocrine Tumors.

PubMed

Krug, Sebastian; Boch, Michael; Rexin, Peter; Gress, Thomas M; Michl, Patrick; Rinke, Anja

2017-05-01

Alkylating chemotherapeutics with either a streptozotocin-(STZ) or temozolomide-(TEM) backbone are routinely used in patients with progressive and unresectable pancreatic neuroendocrine tumors (PNET). In addition, dacarbazine (DTIC) was described as an alternative alkylating therapy option for PNETs. The optimal treatment sequence with alkylating compounds and a potential use of O6-methylguanine-DNA methyltransferase (MGMT) level as predictive biomarker have not yet been sufficiently elucidated. The aim of our study was the evaluation of therapy sequence with either STZ-based treatment followed by DTIC (group A) or the inverse schedule with upfront DTIC (group B) and to correlate MGMT status with clinicopathological characteristics and response to therapy. We retrospectively analyzed 28 patients with neuroendocrine tumors (NET) who were treated with STZ-based therapy and DTIC. Additionally, in a second group MGMT immunohistochemistry was performed from primary and metastatic tumor sites. For statistical evaluation Kaplan-Meier analysis, Cox regression methods and Fisher's exact test were used. There was no difference of objective response and disease control between either STZ-based therapy followed by DTIC treatment (group A) after progression or the reverse sequence (group B). Median time to progression (TTP) was estimated to be 21 months in both arms. First-line STZ-based chemotherapy was not superior to first-line DTIC treatment (16 vs. 13 months; p=0.8). MGMT status did not correlate with clinicopathological characteristics or response to therapy with these alkylating agents. Upfront chemotherapy with either STZ-based treatment or DTIC monotherapy showed similar efficacy and median TTP rates. In this study, MGMT protein expression assessed by immunohistochemistry did not play an important role as a predictive marker for alkylating agents. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Sequential Combination Chemotherapy of Dacarbazine (DTIC) with Carboplatin and Paclitaxel for Patients with Metastatic Mucosal Melanoma of Nasal Cavity and Paranasal Sinuses.

PubMed

Omata, W; Tsutsumida, A; Namikawa, K; Takahashi, A; Oashi, K; Yamazaki, N

2017-01-01

By the recent introduction of molecular targeting drugs against BRAF mutation and immune checkpoint inhibitors, the prognosis of patients with melanoma in advanced stage is now improving, but still in the minority. Mucosal melanoma lacks the BRAF mutations, and hence conventional chemotherapeutic regimens must be improved. We have conventionally used dacarbazine (DTIC) for patients with metastatic mucosal melanoma. However, the efficacy of DTIC in patients with metastatic mucosal melanoma has been limited. Therefore, we explored other possibilities to improve the prognosis of patients suffering from metastatic mucosal melanoma. In this communication, we present a retrospective analysis of the sequential combination chemotherapy of DTIC with carboplatin and paclitaxel (CP) for metastatic mucosal melanoma of nasal cavity and paranasal sinuses. The objective response rate of seven patients is 14.3% by RECIST 1.1 and the overall survival (OS) is 12.5 months. These data indicate that the sequential combination chemotherapy of DTIC with CP could be an option for patients with metastatic mucosal melanoma of nasal cavity and paranasal sinuses who are currently ending into dismal prognosis.

48 CFR 252.235-7011 - Final scientific or technical report.

Code of Federal Regulations, 2014 CFR

2014-10-01

... technical report. 252.235-7011 Section 252.235-7011 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... of the report; and (c) For submission of reports in other than paper copy, contact the Defense...

48 CFR 252.235-7011 - Final scientific or technical report.

Code of Federal Regulations, 2012 CFR

2012-10-01

... technical report. 252.235-7011 Section 252.235-7011 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... of the report; and (c) For submission of reports in other than paper copy, contact the Defense...

48 CFR 252.235-7011 - Final scientific or technical report.

Code of Federal Regulations, 2010 CFR

2010-10-01

... technical report. 252.235-7011 Section 252.235-7011 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... of the report; and (c) For submission of reports in other than paper copy, contact the Defense...

48 CFR 252.235-7011 - Final scientific or technical report.

Code of Federal Regulations, 2011 CFR

2011-10-01

... technical report. 252.235-7011 Section 252.235-7011 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... of the report; and (c) For submission of reports in other than paper copy, contact the Defense...

48 CFR 252.235-7011 - Final scientific or technical report.

Code of Federal Regulations, 2013 CFR

2013-10-01

... technical report. 252.235-7011 Section 252.235-7011 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... of the report; and (c) For submission of reports in other than paper copy, contact the Defense...

[Hypersensitivity to dacarbazine in patients with metastatic malignant melanoma].

PubMed

Levy, A; Guitera, P; Kerob, D; Ollivaud, L; Archimbaud, A; Dubertret, L; Basset-Seguin, N

2006-02-01

Dacarbazine (DTIC) is the first-line chemotherapy for metastatic malignant melanoma without cerebral metastasis. Its clinical and hematological safety is usually good. Hypersensitivity in hepatic failure patients is the most serious side effect described. This was a retrospective study of the prevalence of hypersensitivity in patients treated with DTIC for metastatic melanoma between 11/01/2002 and 10/31/2003. Hypersensitivity was diagnosed in the event of fever, hypereosinophilia (> 500/mm3) with or without liver dysfunction (> twice pre-therapeutic values). Clinical data, DTIC administration modalities, number of courses and clinical and laboratory safety data were recorded. Twenty patients were included, 11 women and 9 men of median age 58.6 years (22-82 years) with multiple metastases in all cases. DTIC was the first-line treatment for 19 patients, being administered for 4 days to 10 patients and for 1 day to the other 10 patients, depending on their overall health status. Five hypersensitivity-like manifestations were observed, all in the 4-day treatment group. In 3 patients, fever and hypereosinophilia were seen without liver dysfunction at D3 of the second course of treatment. In 2 patients, treatment was stopped after the second course because of disease progression. In the third patient, 4 courses were given with recurrence of symptoms, although the latter were controlled during the fifth course with corticosteroids and antihistamines given 15 minutes before the start of treatment. Two patients experienced severe forms of hypersensitivity with fever, hypereosinophilia, liver dysfunction (cytolysis and cholestasis) and delayed medullar aplasia, after the first and second course respectively. In one patient, bone marrow examination showed a block at the promyelocytic stage consistent with a toxic etiology. Treatment with DTIC was stopped, and all signs regressed with symptomatic treatment. Hypersensitivity with DTIC seems to be frequent, being observed in 20% of our patients, with early onset (after the first or second course) and absence of dose-dependence. We describe for the first time two cases of medullar aplasia occurring in association with DTIC hypersensitivity. During phase I studies, the hematologic toxicity of DTIC was moderate, rarely affecting red cells, and was observed with higher doses than those used in metastatic malignant melanoma. We suggest that this aplasia forms part of the signs of hypersensitivity because of the bone marrow morphology, the existence of anemia and concomitant resolution with all the others signs of hypersensitivity. Laboratory monitoring (NFS, liver enzymes) is thus justified, particularly after the first and second courses of DTIC. In case of fever and hypereosinophilia without liver dysfunction, DTIC may be continued together with symptomatic treatment. In the event of hepatic dysfunction, and of course severe hematological disorders, potentially fatal complications can occur and treatment must be stopped.

22 CFR 124.3 - Exports of technical data in furtherance of an agreement.

Code of Federal Regulations, 2010 CFR

2010-04-01

... approved in writing by the Directorate of Defense Trade Controls (DDTC) and the technical data does not... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exports of technical data in furtherance of an... REGULATIONS AGREEMENTS, OFF-SHORE PROCUREMENT AND OTHER DEFENSE SERVICES § 124.3 Exports of technical data in...

FY 2004 Top 200 Users Survey Report

DTIC Science & Technology

2004-10-01

Rating 82% 79% 80% ACSI Federal Government Benchmark* 71.1% 70.2% 70.9% DTIC Excels by +10.9 +8.8 +9.1 *ACSI is the official service quality benchmark...ACSI Federal Government Benchmark* 71.1% 70.2% 70.9% DTIC Excels by +10.9 +8.8 +9.1 *ACSI is the official service quality benchmark for the Federal...Users Survey % DTIC’s Other Overall Product/ Service Quality and Performance: Not only were we able to ascertain product and service usage data from

An operational system for subject switching between controlled vocabularies

NASA Technical Reports Server (NTRS)

Silvester, June P.; Klingbiel, Paul H.

1993-01-01

The NASA system of automatically converting sets of terms assigned by Department of Defense indexers to sets of NASA's authorized terms is described. This little-touted system, which has been operating successfully since 1983, matches concepts, rather than words. Subject Switching uses a translation table, known as the Lexical Dictionary, accessed by a program that determines which rules to follow in making the transition from DTIC's to NASA's authorized terms. The authors describe the four phases of development of Subject Switching, changes that have been made, evaluating the system, and benefits. Benefits to NASA include saving indexers' time, the addition of access points for documents indexed, the utilization of other government indexing, and a contribution towards the now-operational NASA, online, interactive, machine aided indexing.

76 FR 23641 - Proposed Information Collection: Export Declaration of Defense Technical Data or Services

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-27

... DEPARTMENT OF STATE [Public Notice: 7431] Proposed Information Collection: Export Declaration of Defense Technical Data or Services AGENCY: Department of State. ACTION: Notice of request for public..., Directorate of Defense Trade Controls, Bureau of Political-Military Affairs, U.S. Department of State...

78 FR 30898 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Rights in...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-23

... Data and Computer Software AGENCY: Defense Acquisition Regulations System; Department of Defense (DoD... in Technical Data, and Subpart 227.72, Rights in Computer Software and Computer Software... are associated with rights in technical data and computer software. DoD needs this information to...

75 FR 6640 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... information collection requirement is necessary to assess the level of service the DTIC provides to its... Customer Service Standards.'' Respondents are DTIC registered users who are components of the DoD, military...

32 CFR 50.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... policy governing commercial sponsorship. 1 Copies may be obtained at http://www.dtic.mil/whs/directives... Dictionary of Military and Associated Terms.” 2 2 See http://www.dtic.mil/doctrine/jel/doddict/indexs.html...

Dacarbazine as single-agent therapy for relapsed lymphoma in dogs.

PubMed

Griessmayr, P C; Payne, S E; Winter, J E; Barber, L G; Shofer, F S

2009-01-01

Multidrug resistance is the most common cause of treatment failure in dogs with multicentric lymphoma. 5-(3,3-Dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) is an atypical alkylator used as standard treatment in human Hodgkin's lymphoma, and has been effective in combination treatment to treat resistant lymphoma in dogs. However, no data are available on the use of DTIC as a single agent in the treatment of relapsed canine lymphoma. Single-agent DTIC is effective and safe in treating dogs with lymphoma that relapsed or failed to respond to previous chemotherapy. Forty client-owned dogs with relapsed lymphoma. Dogs were eligible for the retrospective study if they had a histologically or cytologically confirmed diagnosis of lymphoma and had relapsed. Dogs received DTIC (800-1,000 mg/m(2) every 2-3 weeks as a 4-5-hour IV infusion) and were evaluated for response rate and duration. Hematologic and gastrointestinal toxicity was assessed. The overall response rate for dogs being treated with DTIC was 35% (14 dogs) with a median progression-free interval of 43 days. Thirteen dogs had a partial response and 1 dog had a complete response. Stable disease was achieved in 3 dogs. Mild gastrointestinal toxicity was reported in 3 dogs posttreatment. Thrombocytopenia was the principal toxicity observed 7-14 days after the treatment. Treatments were delayed because of thrombocytopenia. DTIC, when used alone, is effective in the treatment of dogs with relapsed lymphoma.

Military and Security Developments Involving the People’s Republic of China 2013

DTIC Science & Technology

2013-01-01

discussions have stalled over pricing differences. China’s Top Crude Suppliers 2011 Country Volume (1,000 barrels per day) Percentage of...the transfer or disclosure of U.S.-origin defense articles, defense services, technical data, and/or technology to China. Additionally, Public Law... transfer or export of defense articles (including technical data) and defense services. Beijing primarily conducts arms sales to enhance foreign

Should Project Managers Buy Technical Data

DTIC Science & Technology

2017-04-06

Should Project Managers Buy Technical Data? Jerry Harper April 6, 2017 PUBLISHED BY The Defense...intellectual property (IP) management and technical data rights (TDR) strategies. According to DoD Instruction 5000.02 (DoD, 2017), project managers (PMs...Defense Authorization Act NDI ................nondevelopmental item PM ................. project manager R&D ...............research and development

Annual Historical Summary, Defense Documentation Center, 1 July 1968 to 30 June 1969.

ERIC Educational Resources Information Center

Defense Documentation Center, Alexandria, VA.

This summary describes the more significant activities and achievements of the Defense Documentation Center (DDC) including: DDC and the scientific and technical community. The DDC role in the Department of Defense Scientific and Technical Information Program continued to shift from the traditional concept of an archival repository and a…

32 CFR 701.54 - Collection of fees and fee rates for technical data.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 5 2013-07-01 2013-07-01 false Collection of fees and fee rates for technical data. 701.54 Section 701.54 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND...

32 CFR 701.54 - Collection of fees and fee rates for technical data.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 5 2012-07-01 2012-07-01 false Collection of fees and fee rates for technical data. 701.54 Section 701.54 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND...

32 CFR 701.54 - Collection of fees and fee rates for technical data.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 5 2011-07-01 2011-07-01 false Collection of fees and fee rates for technical data. 701.54 Section 701.54 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND...

Combination of dacarbazine and dimethylfumarate efficiently reduces melanoma lymph node metastasis.

PubMed

Valero, Teresa; Steele, Silvia; Neumüller, Karin; Bracher, Andreas; Niederleithner, Heide; Pehamberger, Hubert; Petzelbauer, Peter; Loewe, Robert

2010-04-01

Dimethylfumarate (DMF) has been shown to reduce melanoma growth and metastasis in animal models. We addressed the question of whether DMF is as effective in its antitumor activity as the US Food and Drug Administration-approved alkylating agent dacarbazine (DTIC). We also tested the possibility of an improved antitumoral effect when both therapeutics were used together. Using our severe combined immunodeficiency (SCID) mouse model, in which xenografted human melanoma cells metastasize from primary skin sites to sentinel nodes, we show that these treatments, alone or in combination, reduce tumor growth at primary sites. Our main finding was that metastasis to sentinel nodes is significantly delayed only in mice treated with a combination of DTIC and DMF. Subsequent experiments were able to show that a combination of DTIC/DMF significantly reduced lymph vessel density in primary tumors as examined by real-time PCR and immunohistochemistry. In addition, DTIC/DMF treatment significantly impaired melanoma cell migration in vitro. In vivo, DTIC/DMF therapy significantly reduced mRNA expression and protein concentration of the promigratory chemokines CXCL2 and CXCL11. In addition, our data suggest that this xenotransplantation model is suitable for preclinical testing of various combinations of antimelanoma agents.

32 CFR 65.5 - Responsibilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... elements and codes established by DoD Instruction 1336.5 (available at http://www.dtic.mil/whs/directives/corres/pdf/133605p.pdf) and DoD Instruction 7730.54 (available at http://www.dtic.mil/whs/directives...

32 CFR 65.5 - Responsibilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... elements and codes established by DoD Instruction 1336.5 (available at http://www.dtic.mil/whs/directives/corres/pdf/133605p.pdf) and DoD Instruction 7730.54 (available at http://www.dtic.mil/whs/directives...

32 CFR 65.5 - Responsibilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Data System (RCCPDS)” (see http://www.dtic.mil/whs/directives/corres/pdf/773054m_vol1.pdf). (11) Direct... of Active Duty Military Personnel Records” (see http://www.dtic.mil/whs/directives/corres/pdf/133605p...

32 CFR 65.5 - Responsibilities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... elements and codes established by DoD Instruction 1336.5 (available at http://www.dtic.mil/whs/directives/corres/pdf/133605p.pdf) and DoD Instruction 7730.54 (available at http://www.dtic.mil/whs/directives...

Annual Report to Congress: Military and Security Developments Involving the People’s Republic of China 2013

DTIC Science & Technology

2013-01-01

69 bcm of gas per year; discussions have stalled over pricing differences. China’s Top Crude Suppliers 2011 Country Volume (1,000...Tiananmen Sanctions – prohibits the transfer or disclosure of U.S.-origin defense articles, defense services, technical data, and/or technology to...which U.S. policy denies the transfer or export of defense articles (including technical data) and defense services. Beijing primarily conducts

Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour.

PubMed

Stacchiotti, S; Saponara, M; Frapolli, R; Tortoreto, M; Cominetti, D; Provenzano, S; Negri, T; Dagrada, G P; Gronchi, A; Colombo, C; Vincenzi, B; Badalamenti, G; Zuco, V; Renne, S L; Collini, P; Morosi, C; Dei Tos, A P; Bello, E; Pilotti, S; Casali, P G; D'Incalci, M; Zaffaroni, N

2017-05-01

Preclinical models that mimic pathological and molecular features of solitary fibrous tumour (SFT) represent an important tool to select effective regimes and novel compounds to be tested in the clinic. This study was aimed at developing two preclinical models of SFT, assessing their predictive value in the clinic and selecting potential novel effective treatments. Two dedifferentiated-SFT (D-SFT) models obtained from patients' biopsies were grown in immunodeficient mice. The antitumour activity on these models of doxorubicin, dacarbazine (DTIC), ifosfamide (monotherapy or combination), trabectedin and eribulin was tested. Twelve SFT patients were treated with doxorubicin and DTIC. Response by RECIST, progression-free survival and overall survival were retrospectively evaluated, distinguishing malignant-SFT (M-SFT) and D-SFT. Two D-SFT patient-derived xenografts (PDXs) that represent the first available preclinical in vivo models of SFT were developed and characterised. Doxorubicin/DTIC, DTIC/ifosfamide, doxorubicin/ifosfamide combinations consistently induced better antitumour activity than the single-agents. Particularly, doxorubicin/DTIC combination caused a max tumour volume inhibition >80% in both models. Doxorubicin/DTIC combo showed activity also in the case-series. Best RECIST responses were: 6 responses (M-SFT = 2 of 7, D-SFT = 4 of 5), 1 stable disease, 5 progressions, with a 6-month median progression-free survival (M-SFT = 6, D-SFT = 10 months). The PDXs were very sensitive to trabectedin and eribulin. Doxorubicin plus DTIC combination was effective in our two D-SFT mice models and appeared to be active also in the clinic, especially in high-grade D-SFT patients. Among additional drugs tested in the PDXs, trabectedin and eribulin were highly effective, providing a rational to test these drugs in D-SFT patients. Copyright © 2017 Elsevier Ltd. All rights reserved.

32 CFR 158.1 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-07-01

... guidance in DoD Directive 3020.49 (see http://www.dtic.mil/whs/directives/corres/pdf/302049p.pdf) and the authority in DOD Directive 5134.01 (see http://www.dtic.mil/whs/directives/corres/pdf/513401p.pdf). ...

32 CFR 158.1 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-07-01

... guidance in DoD Directive 3020.49 (see http://www.dtic.mil/whs/directives/corres/pdf/302049p.pdf) and the authority in DOD Directive 5134.01 (see http://www.dtic.mil/whs/directives/corres/pdf/513401p.pdf). ...

32 CFR 158.1 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-07-01

... guidance in DoD Directive 3020.49 (see http://www.dtic.mil/whs/directives/corres/pdf/302049p.pdf) and the authority in DOD Directive 5134.01 (see http://www.dtic.mil/whs/directives/corres/pdf/513401p.pdf). ...

77 FR 16591 - Implementation of the Defense Trade Cooperation Treaty Between the United States and the United...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-21

... data for purposes of the exemption. DDTC does not believe this change is necessary as the definition in Sec. 120.6 clearly identifies technical data as within the scope of the ``defense article'' definition. Unless specifically indicated otherwise, the use of the term ``defense article'' includes technical data...

22 CFR 125.1 - Exports subject to this part.

Code of Federal Regulations, 2010 CFR

2010-04-01

... EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.1 Exports subject to this part. (a) The controls of this part apply to the export of technical data and the export of classified defense articles... to the controls of this subchapter. (b) A license for the export of technical data and the exemptions...

Bibliographic Networks and Microcomputer Applications for Aerospace and Defense Scientific and Technical Information.

ERIC Educational Resources Information Center

Hartt, Richard W.

This report discusses the characteristics, operations, and automation requirements of technical libraries providing services to organizations involved in aerospace and defense scientific and technical work, and describes the Local Automation Model project. This on-going project is designed to demonstrate the concept of a fully integrated library…

[Methods for reducing dacarbazine photodegradation and its accompanying venous pain].

PubMed

Tsuji, Takumi; Ohtsubo, Tatsuya; Umeyama, Takayo; Sudou, Miho; Komesu, Kana; Matsumoto, Minako; Yoshida, Yuya; Banno, Rie; Mikami, Tadashi; Kohno, Takeyuki

2014-01-01

The anticancer drug dacarbazine (DTIC) is photosensitive, and the photodegradation product 5-diazoimidazole-4-carboxamide (diazo-IC) induces adverse reactions including local venous pain during intravenous injection. In this study we evaluated the effectiveness of colored shields (orange and red) to protect against photodegradation of DTIC as determined by ascertaining the concentration of diazo-IC. Samples were prepared and stored under four conditions: (1) no shield; (2) covered with an aluminum (opaque) shield; (3) covered with an orange shield; and (4) covered with a red shield. The samples were exposed to natural light for a specified time (0, 30, 60, 120, and 180 min) prior to measuring the concentration of diazo-IC by HPLC. We found that after 180 min, the diazo-IC concentration was 5.7±0.6 (S.D.) μg/mL with no shield and 1.9±0.2 μg/mL in both colored shield conditions. This production of diazo-IC under the colored shields was suppressed to a level similar to that under the aluminum shield (1.7±0.2 μg/mL). We also evaluated the effectiveness of NSAIDs (zaltoprofen, loxoprofen sodium, and diclofenac sodium) administered to mice prior to DTIC treatment on venous pain by counting their stretching and writhing reactions. Premedication with zaltoprofen significantly decreased expression of pain behavior in the DTIC-treated mice. These results suggest that storing DTIC under the protection of an orange or red shield is clinically beneficial because the shield prevents DTIC photodegradation, and that NSAIDs such as zaltoprofen are a promising premedication candidate for pain.

Technical-tactical analysis of youth olympic taekwondo combat.

PubMed

Tornello, Francesco; Capranica, Laura; Minganti, Carlo; Chiodo, Salvatore; Condello, Giancarlo; Tessitore, Antonio

2014-04-01

The purpose of this study was to define the technical and tactical profiles of official youth taekwondo competitions played under the most recent rules of the International Taekwondo Federation. Tactical actions (i.e., attack, defense, and block), technical executions (from 1- to 4-point scores), kicking legs (i.e., front/rear and right/left), and overall technical effectiveness were investigated in relation to match outcome of semifinal and final competitions (n = 50) of youth (aged 13-14 years) black belt athletes during the Italian Taekwondo Cadet Championship. Differences (p < 0.001) were found among all action typologies (Attack: 50.9 ± 2.2%; Defense: 27.7 ± 1.5%; Block: 21.3 ± 1.6%), with winners showing fewer (p = 0.005) offensive actions and more (p = 0.001) defensive actions with respect to non-winners. Independently from match outcome, technical exchanges showed differences (p < 0.001) for technical executions. Winners resulted more efficient (p < 0.001) for both technical and tactical variables. In general, these findings showed that Cadets tend to adopt an offensive strategy. In considering that the adoption of the new electronic system requires athletes to execute correct technical actions to have a score assigned, coaches should emphasize the effectiveness of scoring techniques and help athletes to effectively improve their defense and counterattack capabilities.

32 CFR 283.5 - Responsibilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... to enclosure 2 of DoD Directive 5118.3. 1 1 Available at http://www.dtic.mil/whs/directives/. (2) If... application pursuant to enclosure 2 of DoD Directive 1342.6. 2 2 Available at http://www.dtic.mil/whs...

32 CFR 283.5 - Responsibilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... to enclosure 2 of DoD Directive 5118.3. 1 1 Available at http://www.dtic.mil/whs/directives/. (2) If... application pursuant to enclosure 2 of DoD Directive 1342.6. 2 2 Available at http://www.dtic.mil/whs...

32 CFR 283.5 - Responsibilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... to enclosure 2 of DoD Directive 5118.3. 1 1 Available at http://www.dtic.mil/whs/directives/. (2) If... application pursuant to enclosure 2 of DoD Directive 1342.6. 2 2 Available at http://www.dtic.mil/whs...

32 CFR 283.5 - Responsibilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... to enclosure 2 of DoD Directive 5118.3. 1 1 Available at http://www.dtic.mil/whs/directives/. (2) If... application pursuant to enclosure 2 of DoD Directive 1342.6. 2 2 Available at http://www.dtic.mil/whs...

32 CFR 213.1 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-07-01

... obtained at http://www.dtic.mil/whs/directives/. (c) Designates the Secretary of the Army as the DoD Executive Agent (DoD EA) according to DoD Directive 5101.1: 2 2 Copies may be obtained at http://www.dtic...

32 CFR 213.1 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-07-01

... obtained at http://www.dtic.mil/whs/directives/. (c) Designates the Secretary of the Army as the DoD Executive Agent (DoD EA) according to DoD Directive 5101.1: 2 2 Copies may be obtained at http://www.dtic...

32 CFR 283.5 - Responsibilities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... to enclosure 2 of DoD Directive 5118.3. 1 1 Available at http://www.dtic.mil/whs/directives/. (2) If... application pursuant to enclosure 2 of DoD Directive 1342.6. 2 2 Available at http://www.dtic.mil/whs...

32 CFR 213.1 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-07-01

... obtained at http://www.dtic.mil/whs/directives/. (c) Designates the Secretary of the Army as the DoD Executive Agent (DoD EA) according to DoD Directive 5101.1: 2 2 Copies may be obtained at http://www.dtic...

32 CFR 213.1 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-07-01

... obtained at http://www.dtic.mil/whs/directives/. (c) Designates the Secretary of the Army as the DoD Executive Agent (DoD EA) according to DoD Directive 5101.1: 2 2 Copies may be obtained at http://www.dtic...

32 CFR 213.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... obtained at http://www.dtic.mil/whs/directives/. (c) Designates the Secretary of the Army as the DoD Executive Agent (DoD EA) according to DoD Directive 5101.1: 2 2 Copies may be obtained at http://www.dtic...

Bright Light Therapy for Treatment of Sleep Problems Following Mild TBI https://www.dacspr.documentservices.dla.mil/dtic/livelink func=formwf.formedit and workid=4132484 and subworkid=4132484 and taskid=8 and formID=1 and viewname=jhg and editable=1176347093 and nexturl=%2Fdtic%2Flivelink%3Ffunc%3Dwork%2Etaskdone%26workid%3D4132484%26subworkid%3D4132484%26taskid%3D8%26xAction%3Dsave%26paneindex%3D1%26nexturl%3D%252Fdtic%252Flivelink%253Ffunc%253Dllworkspace and noredisplay=1#

DTIC Science & Technology

2016-10-01

00) and at night (between 00:00 and 04:00), and found that participants reported lower levels of sleepiness and fatigue, pii: sp-00684-15 ht tp...Chief Psychologist, GovSource, Inc., U.S. Department of Defense (DoD) Contractor 8/08 Consulting Psychologist, The Brain Institute, University of

Pharmacokinetics of dacarbazine (DTIC) in pregnancy.

PubMed

Kantrowitz-Gordon, Ira; Hays, Karen; Kayode, Olumide; Kumar, Aditya R; Kaplan, Henry G; Reid, Joel M; Safgren, Stephanie L; Ames, Matthew M; Easterling, Thomas R; Hebert, Mary F

2018-03-01

The purpose of this report is to describe, for the first time, the pharmacokinetics of dacarbazine (DTIC) and its metabolites [5-[3-methyl-triazen-1-yl]-imidazole-4-carboxamide (MTIC), 5-[3-hydroxymethyl-3-methyl-triazen-1-yl]-imidazole-4-carboxamide (HMMTIC) and 5-aminoimidazole-4-carboxamide (AIC)] during pregnancy (n = 2) and postpartum (n = 1). Non-compartmental DTIC, MTIC, HMMTIC, and AIC pharmacokinetics (PK) were estimated in one case at 29 week gestation and 18 day postpartum and a second case at 32 week gestation, in women receiving DTIC in combination with doxorubicin, bleomycin, and vinblastine for treatment of Hodgkin's lymphoma. Drug concentrations were measured by HPLC. In the subject who completed both pregnancy and postpartum study days, DTIC area under the concentration-time curve (AUC) was 27% higher and metabolite AUCs were lower by 27% for HMMTIC, 38% for MTIC, and 83% of AIC during pregnancy compared to postpartum. At 7 and 9 year follow-up, both subjects were in remission of their Hodgkin's lymphoma. Based on these two case reports, pregnancy appears to decrease the metabolism of the pro-drug dacarbazine, likely through inhibition of CYP1A2 activity. Lower concentrations of active metabolites and decreased efficacy may result, although both these subjects experienced long-term remission of their Hodgkin's lymphoma.

Topical CpG enhances the response of murine malignant melanoma to dacarbazine.

PubMed

Najar, Hossain M; Dutz, Jan P

2008-09-01

Malignant melanoma is a potentially fatal skin cancer that is increasing in incidence. Standard chemoimmunotherapy consisting of dacarbazine (DTIC) given with IFN-alpha has had disappointing results. We describe a chemoimmunotherapy protocol for cutaneous melanoma that combines the administration of DTIC with the topical application of CpG oligodinucleotide (ODN). Subcutaneous B16 melanoma tumors in C57BL/6 mice were treated with intraperitoneal injections of DTIC followed by the topical application of CpG-ODN over the tumors. This therapeutic approach abrogated the growth of established tumors and significantly enhanced survival. Topical CpG application was more effective than intratumoral CpG. Cell depletion studies indicated that the antitumor effect was dependent on both CD4(+) and CD8(+) cells but not on natural killer (NK) cells. Tumor-specific cytotoxic T-lymphocyte activity was generated in treated animals and was highest in topically treated animals. Immunohistochemical analysis revealed that DTIC, but not CpG, enhanced tumor cell apoptosis. Further, topical CpG induced an expansion of a B220(+)CD8(+) subset of dendritic cells and a subset of NK1.1(+) CD11c(+) cells within the tumors. By enhancing both tumor cell death and local immune activation, DTIC/topical CpG chemoimmunotherapy induced an effective T-cell-dependent host-immune response against melanoma.

Results of a multicenter randomized study to evaluate the safety and efficacy of combined immunotherapy with interleukin-2, interferon-{alpha}2b and histamine dihydrochloride versus dacarbazine in patients with stage IV melanoma.

PubMed

Middleton, M; Hauschild, A; Thomson, D; Anderson, R; Burdette-Radoux, S; Gehlsen, K; Hellstrand, K; Naredi, P

2007-10-01

The safety and efficacy of immunotherapy with histamine dihydrochloride (HDC), interleukin-2 (IL-2) and interferon-alpha2b (IFN) compared with dacarbazine (DTIC) in adult patients with stage IV melanoma was evaluated. Two hundred and forty-one patients were randomized to either receive repeated 4-week cycles of IFN [3 MIU, s.c., once daily for 7 days], IL-2 (2.4 MIU/m(2), s.c., twice a day for 5 days) and HDC (1 mg, s.c., twice a day for 5 days) or DTIC 850 mg/m(2) i.v. every 3 weeks. The primary endpoint was overall survival. Median survival was longer for patients receiving HDC/IL-2/IFN (271 days) than for patients receiving DTIC (231 days), but this did not achieve statistical significance. Four patients receiving HDC/IL-2/IFN and nine receiving DTIC experienced at least one grade 4 adverse event. Striking differences in overall survival were observed between countries participating in the study. Treatment with HDC/IL-2/IFN was safely administered on an outpatient basis, but this immunotherapeutic regimen did not improve upon the response rate and overall survival seen with DTIC.

Validated hydrophilic interaction LC-MS/MS method for simultaneous quantification of dacarbazine and 5-amino-4-imidazole-carboxamide in human plasma.

PubMed

Liu, Yanhong; Zhang, Weihua; Yang, Yuhui

2008-10-19

A hydrophilic interaction high performance liquid chromatography-tandem mass spectrometric method has been developed and validated for simultaneous quantification of dacarbazine (DTIC) and its terminal metabolite, 5-amino-4-imidazole-carboxamide (AIC) in human plasma. The plasma samples are first extracted by a C8+SCX mixed-mode 96-well plate to extend the extraction stability of DTIC and AIC. The extracted residues are further cleaned by a primary and secondary amine (PSA) adsorbent for minimization of matrix effect. Analyses are done on an Amide-80 HPLC column coupled to a tandem mass spectrometer fitted with an atmospheric pressure turbo ion spray ionization interface in the positive-ion mode. Both DTIC and AIC have reproducible retention times on the Amide-80 HPLC column. This type of column not only has an excellent column life (over 4000 injections), but also has zero carryover effect. The injection volume should be limited at 10 microL or less to avoid the peak splitting. The validated concentration ranges are from 0.5 to 500 ng/mL for DTIC and from 2.0 to 500 ng/mL for AIC. The validated method has been successfully applied to determine the pharmacokinetic profiles for human patients receiving DTIC infusions.

Combined pitavastatin and dacarbazine treatment activates apoptosis and autophagy resulting in synergistic cytotoxicity in melanoma cells.

PubMed

Al-Qatati, Abeer; Aliwaini, Saeb

2017-12-01

Melanoma is an aggressive skin cancer and its incidence is increasing faster than any other type of cancer. Whilst dacarbazine (DTIC) is the standard chemotherapy for metastatic melanoma, it has limited success. Statins, including pitavastatin, have been demonstrated to have a range of anti-cancer effects in a number of human cancer cell lines. The present study therefore explored the anti-cancer activity of combined DTIC and pitavastatin in A375 and WM115 human melanoma cells. Cell survival assays demonstrated that combined DTIC and pitavastatin treatment resulted in synergistic cell death. Cell cycle analyses further revealed that this combined treatment resulted in a G1 cell cycle arrest, as well as a sub-G1 population, indicative of apoptosis. Activation of apoptosis was confirmed by Annexin V-fluorescein isothiocyanate/propidium iodide double-staining and an increase in the levels of active caspase 3 and cleaved poly (ADP-ribose) polymerase. Furthermore, it was demonstrated that apoptosis occurs through the intrinsic pathway, evident from the release of cytochrome c. Finally, combined DTIC and pitavastatin treatment was demonstrated to also activate autophagy as part of a cell death mechanism. The present study provides novel evidence to suggest that the combined treatment of DTIC and pitavastatin may be effective in the treatment of melanoma.

Combined pitavastatin and dacarbazine treatment activates apoptosis and autophagy resulting in synergistic cytotoxicity in melanoma cells

PubMed Central

Al-Qatati, Abeer; Aliwaini, Saeb

2017-01-01

Melanoma is an aggressive skin cancer and its incidence is increasing faster than any other type of cancer. Whilst dacarbazine (DTIC) is the standard chemotherapy for metastatic melanoma, it has limited success. Statins, including pitavastatin, have been demonstrated to have a range of anti-cancer effects in a number of human cancer cell lines. The present study therefore explored the anti-cancer activity of combined DTIC and pitavastatin in A375 and WM115 human melanoma cells. Cell survival assays demonstrated that combined DTIC and pitavastatin treatment resulted in synergistic cell death. Cell cycle analyses further revealed that this combined treatment resulted in a G1 cell cycle arrest, as well as a sub-G1 population, indicative of apoptosis. Activation of apoptosis was confirmed by Annexin V-fluorescein isothiocyanate/propidium iodide double-staining and an increase in the levels of active caspase 3 and cleaved poly (ADP-ribose) polymerase. Furthermore, it was demonstrated that apoptosis occurs through the intrinsic pathway, evident from the release of cytochrome c. Finally, combined DTIC and pitavastatin treatment was demonstrated to also activate autophagy as part of a cell death mechanism. The present study provides novel evidence to suggest that the combined treatment of DTIC and pitavastatin may be effective in the treatment of melanoma. PMID:29344241

75 FR 59102 - Defense Federal Acquisition Regulation Supplement; Part 204, Administrative Matters

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... indexing methodology across DoD. This technical amendment adds language to the Defense Federal Acquisition... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 204 Defense Federal Acquisition Regulation Supplement; Part 204, Administrative Matters AGENCY: Defense Acquisition Regulations...

Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines.

PubMed

Lillehammer, Trine; Engesaeter, Birgit O; Prasmickaite, Lina; Maelandsmo, Gunhild M; Fodstad, Oystein; Engebraaten, Olav

2007-06-01

Currently, dacarbazine (DTIC) is the only approved systemic treatment for metastatic malignant melanoma. However, the modest treatment effect encourages studies on novel therapeutic molecules, delivery systems and combination therapies. Full-length TRAIL, delivered from an adenoviral vector (Ad-hTRAIL), was studied in combination with DTIC or the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) in human melanoma cell lines. The cytotoxic potential of the combination treatments was assessed by cell viability measurements and CalcuSyn analysis. Involvement of apoptosis was analyzed by TUNEL staining, mitochondrial membrane potential measurements, and activation and expression levels of caspases and other mediators of apoptosis. Ad-hTRAIL in combination with DTIC or SAHA resulted in additive or synergistic growth inhibition compared to each treatment used as single agent. Both combinations augmented apoptosis, which was mediated through the death receptor (DR) pathway by enhanced activation of caspase-8, and through increased loss of mitochondrial integrity. Provoked cleavage of Bid, which bridges the extrinsic and intrinsic apoptosis pathways, and downregulation of the anti-apoptotic mediators Bcl-X(L), Mcl-1 and XIAP (but not Bcl-2) were critical contributing factors. Increased levels of DR4 and DR5 were not a common underlying mechanism as DTIC did not affect the levels of either of the receptors. However, SAHA-induced expression of DR4 may have reduced the TRAIL resistance in the SKMEL-28 cell line. Administration of Ad-hTRAIL in combination with DTIC or SAHA enhances apoptosis in human melanoma cell lines, and suggests that the therapeutic potential of such treatment strategies should be further evaluated for possible clinical use.

Low dose DTIC is effective and safe in pretreated patients with well differentiated neuroendocrine tumors.

PubMed

Mueller, Daniela; Krug, Sebastian; Majumder, Moushumee; Rinke, Anja; Gress, Thomas Matthias

2016-08-18

Streptozocin (STZ) based chemotherapy is recommended for patients with metastatic pancreatic neuroendocrine tumors (pNET). Temozolomide as mono- or combination therapy has been suggested to be a promising alternative. However, the treatment is costly and not approved for the treatment of pNETs. Dacarbazine (DTIC) shares the active metabolite with temozolomide and is broadly available at a low cost. The aim of this study was a retrospective evaluation of the efficacy and tolerability of a lower dose DTIC-regimen in patients with progressive advanced NETs. We retrospectively analyzed 75 patients with NETs predominantly of pancreatic origin treated at our center between 1998 and 2013. 650 mg/m(2) of DTIC were administered intravenously over 60 min every 4 weeks. Morphological response was assessed according to RECIST1.1 criteria. The median progression free survival (PFS) was calculated using Kaplan-Meier and Cox regression methods, respectively. Univariate analyses of possible prognostic markers were performed. The objective response rate (ORR) was 27 % for the entire cohort and 32 % in 50 pNET patients, respectively. Stable disease (SD) was documented in 29 patients (39 %). Median PFS (mPFS) in patients receiving DTIC was 7 months (3.9-10; 95 % confidence interval). Radiological and biochemical response were the only significant prognostic markers for longer PFS in univariate analysis. Treatment was well tolerated. Nausea was the most common side effect (31 %), only one case (1.3 %) of grade 3 toxicity (vomiting) occurred. Low dose DTIC chemotherapy is an effective and well-tolerated treatment option in patients with progressive well differentiated neuroendocrine neoplasms, especially of pancreatic origin.

Defense Information Systems Agency (DISA) GIG Convergence Master Plan 2012 (GCMP 2012). Volume 1

DTIC Science & Technology

2012-08-02

mapping, the complete DISA technical baseline, and the GIG Technical Guidance ( GTG ). The Department of Defense (DoD), as part of its IT Effectiveness...Guidance ( GTG ) to guide their development of service offerings, which are added to the technical baseline when approved by the CEP. 1.2. Background...corresponding hyperlinks; the complete set of GTPs is called the GIG Technical Guidance ( GTG ). These appendices also contain linkages between the GCMP

78 FR 24392 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-25

... Information Center (DTIC), Marketing and Registration Division, 8725 John J. Kingman Road, Suite 0944, ATTN: Ms. Angela Davis, Ft. Belvoir, VA 22060- 6218, or call the DTIC Marketing and Registration Division at (703) 767-8207. Title; Associated Form; and OMB Number: Customer Satisfaction Surveys--Generic...

Dental Fitness Class 3 Treatment Needs: A Report of Consultation

DTIC Science & Technology

1992-10-20

services of the Defense Technical Information Center (per DOD Instruction 5200.21) may purchase copies directly from the following: Defense Technical ...All other requests for these reports will be directed to the fowing: :9 U.S. Department of Commerce i’-? National Technical Information Services (NTIS...oral malignancies. 12 Temporomandibular joint disorders - myofascial pain dysfunction; dislocation, subluxation or other associated conditions. 13

78 FR 33994 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-06

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 252 RIN Number 0750-AG38 Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to Technical Data (DFARS 2009-D031); Correction AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD...

Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance

PubMed Central

Azimi, A; Pernemalm, M; Frostvik Stolt, M; Hansson, J; Lehtiö, J; Egyházi Brage, S; Hertzman Johansson, C

2014-01-01

Background: Disseminated cutaneous malignant melanoma (CMM) is commonly unresponsive to standard chemotherapies, and there are as yet no predictive markers of therapy response. Methods: In the present study we collected fresh-frozen pretreatment lymph-node metastasis samples (n=14) from melanoma patients with differential response to dacarbazine (DTIC) or temozolomide (TMZ) chemotherapy, to identify proteins with an impact on treatment response. We performed quantitative protein profiling using tandem mass spectrometry and compared the proteome differences between responders (R) and non-responders (NR), matched for age, gender and histopathological type of CMM. Results: Biological pathway analyses showed several signalling pathways differing between R vs NR, including Rho signalling. Gene expression profiling data was available for a subset of the samples, and the results were compared with the proteomics data. Four proteins with differential expression between R and NR were selected for technical validation by immunoblotting (ISYNA1, F13A1, CSTB and S100A13), and CSTB and S100A13 were further validated on a larger sample set by immunohistochemistry (n=48). The calcium binding protein S100A13 was found to be significantly overexpressed in NR compared with R in all analyses performed. Conclusions: Our results suggest that S100A13 is involved in CMM resistance to DTIC/TMZ. PMID:24722184

32 CFR 901.14 - Regular airmen category.

Code of Federal Regulations, 2010 CFR

2010-07-01

... application package from the technical training center CBPO to USAFA/RRS includes the following information on... National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE MILITARY TRAINING AND.... Applicants not selected are reassigned on Academy notification to the CBPO. Applicants to technical school...

32 CFR 318.4 - Policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Policy. 318.4 Section 318.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DEFENSE... administrative, technical, and physical safeguards shall be established, based on the media (e.g., paper...

32 CFR 318.4 - Policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Policy. 318.4 Section 318.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DEFENSE... administrative, technical, and physical safeguards shall be established, based on the media (e.g., paper...

32 CFR 249.1 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Purpose. 249.1 Section 249.1 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION... technical information in the possession or under the control of the Department of Defense at conferences and...

32 CFR 249.1 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Purpose. 249.1 Section 249.1 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION... technical information in the possession or under the control of the Department of Defense at conferences and...

32 CFR 249.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Purpose. 249.1 Section 249.1 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION... technical information in the possession or under the control of the Department of Defense at conferences and...

32 CFR 249.1 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Purpose. 249.1 Section 249.1 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION... technical information in the possession or under the control of the Department of Defense at conferences and...

32 CFR 249.1 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Purpose. 249.1 Section 249.1 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION... technical information in the possession or under the control of the Department of Defense at conferences and...

75 FR 6185 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Rights in...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-08

...; Defense Federal Acquisition Regulation Supplement; Rights in Technical Data and Computer Software (OMB... 227.72, Rights in Computer Software and Computer Software Documentation, and related provisions and... rights in technical data and computer software. DoD needs this information to implement 10 U.S.C. 2320...

78 FR 30233 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... Number 0750-AG38 Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access... Government support contractors to have access to proprietary technical data belonging to prime contractors and other third parties, provided that the technical data owner may require the support contractor to...

Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy.

PubMed

Lewis, Benjamin C; Korprasertthaworn, Porntipa; Miners, John O

2016-10-01

To extend our understanding of how interindividual variability mediates the efficacy of cancer treatment. The kinetics of dacarbazine (DTIC) N-demethylation by the most frequent polymorphic variants of CYP1A1 (T461N, I462V) and CYP1A2 (F186L, D348N, I386F, R431W, R456H) were characterized, along with kinetic parameters for the O-deethylation of the prototypic CYP1A substrate 7-ethoxyresorufin, using recombinant protein expression and high-performance liquid chromatographic techniques. A reduction of ∼30% in the catalytic efficiencies (measured as in-vitro intrinsic clearance, CLint) was observed for DTIC N-demethylation by the two CYP1A1 variants relative to wild type. Although a modest increase in the CLint value for DTIC N-demethylation was observed for the CYP1A2 D348N variant relative to the wild type, the CLint for the F186L variant was reduced and the I386F, R431W, and R456H variants all showed loss of catalytic function. Comparison of the kinetic data for DTIC N-demethylation and 7-ethoxyresorufin O-deethylation indicated that alterations in the kinetic parameters (Km, Vmax, CLint) observed with each of the CYP1A1 and CYP1A2 polymorphic variants were substrate dependent. These data indicate that cancer patients treated with DTIC who possess any of the CYP1A1-T461N and I462V variants or the CYP1A2-F186L, D348N, I386F, R431W, and R456H variants are likely to have decreased prodrug activation, and hence may respond less favorably to DTIC treatment compared with individuals with wild-type CYP1A alleles.

75 FR 51327 - Bureau of Political-Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-19

..., and defense services for the Hughes Air Defense Radar and Air Defense System (HADAR) in Taiwan for the... technical data, and defense services, for the GD-53 Multimode Radar on Taiwan's Indigenous Defensive Fighter... agreement associated with this notification consists of components of the GD-53 Multimode Radar. The end...

22 CFR 120.9 - Defense service.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Defense service. (a) Defense service means: (1) The furnishing of assistance (including training) to..., destruction, processing or use of defense articles; (2) The furnishing to foreign persons of any technical...) Military training of foreign units and forces, regular and irregular, including formal or informal...

76 FR 13297 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-11

... 215 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System... Director, Defense Procurement and Acquisition Policy. DATES: Effective Date: March 11, 2011. Applicability... adding a section at 215.300 with a reference to Director, Defense Procurement and Acquisition Policy...

Notes on Use of the Single Solution Ascorbic Acid Method for Phosphate Determinations: An Amended Method.

DTIC Science & Technology

1984-12-01

here. DTICS LECTE Accession For FEB 13 1985DNISP DTIC T ’ L] pL B ,.T’- -. DiO1 ’’ / Av .1t, ’V: (".i22 " Dist A’ 1’ o% . "o . N"""* L % % TA13LF OF

Detection of T-2 Toxin by an Improved Radioimmunoassay

DTIC Science & Technology

1983-02-01

M. A. Mehlman led.). Mycotoxins in human and animal health . of the extraction steps, the shorter incubation Pathotox Publishers Inc., Park Forest...and animal health . Pathotox 742. Publishers Inc.. Park Forest South. Ill. Accession For NTIS GRA&I DTIC TAB 0 Unannounced 5 DTIC Justification ELECTE 117_ _ Distribution/ OC Availability Codes B DIt special ,41 - .

32 CFR 161.4 - Policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Instruction 1000.1, “Identity Cards Required by the Geneva Convention” (available at http://www.dtic.mil/whs...” (available at http://www.dtic.mil/whs/directives/corres/pdf/100025p.pdf). (d) The CAC, a form of DoD ID card... Contractors” (available at http://www.dhs.gov/xabout/laws/gc_1217616624097.shtm). (e) ID cards, in a form...

German Women in the Five New Lander: Employment and Entrepreneurship

DTIC Science & Technology

1992-12-01

AD-A259 101 GERMAN WOMEN IN THE FIVE NEW LANDER: EMPLOYMENT AND ENTREPRENEURSHIP * DTIC_S EECTE = EC31992 J Maella Blalock Lohman Ai U Submitted to...iv II II TABLE OF CONTENTS CHAPTER 1: Introduction ................................ 1 Women Entrepreneurs ...................... 4 Entrepreneurship ...and Family Life ......... 19 Entrepreneurship in the GDR ............. 25 CHAPTER 3: Present Conditions ......................... 31 Unemployment and

Proceedings of the International Pyrotechnics Seminar (7th) Held at Vail, Colorado, 14-18 July 1980. Volume 1

DTIC Science & Technology

1980-07-18

DISTRIBUTION STAMP DATE RETURNED 84 08 28 040 DA rE RECEIVED IN DTIC REGISTERED OR CERTIFIED NO. PHOTOGRAPH THIS SHEET AND RETURN TO DTIC.I) DAC DTIC FORM 70A...indicated that pressed pyrotechnic and explosive samples 310 00 ;Z 41 -J -o Qj d• O Ob~e.o to 0 CLC 00 4-) 4.- cJC S4-)u0)0 to 0 CA 0)0 ,4) - a) S-4...1430, 1040 cm-1 (also 1295 and 1170 cm- 1 but not apparent due to CIO) TLC Rf .75..79 TA ,nm I, (moles/ý)- 1 I2 1 334 60 T’Ig Ag 464 60 326 15 The N

The Story of the Defense Technical Information Center 1945 - 1995, 50 Years of Information for Defense

DTIC Science & Technology

1995-07-01

necessary. As John Naisbitt observed in his 1982 book Megatrends , ...with the coming of the infor- mation society, we have for the first time an economy...information in the hands of many. —John Naisbitt Megatrends As the Defense Technical Information Center moves forward into the last decade of the...Gulf War, for example, Iraq’s leader, Saddam Hussein, threatened to use biological or biochemical warfare. To defend against this threat, the U.S

78 FR 38235 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-26

.... DATES: Effective Date: June 26, 2013. FOR FURTHER INFORMATION CONTACT: Mrs. Kortnee Stewart, Defense.... Kortnee Stewart, Editor, Defense Acquisition Regulations System. Therefore, 48 CFR parts 225 and 252 are...

78 FR 17993 - Defense Trade Advisory Group; Notice of Open Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-25

... policies, regulations, and technical issues affecting defense trade. The purpose of the meeting will be to... discussed: review of the current definitions of technical data, as well as the control language applied in... statement to the committee in writing. As seating is limited to 125 persons, those wishing to attend the...

FRINGE EFFECTS OF VALUE ENGINEERING. A SURVEY PREPARED BY THE TECHNICAL SUBCOMMITTEE, AOA SPECIAL COMMITTEE ON VALUE ENGINEERING FOR THE OFFICE OF THE ASSISTANT SECRETARY OF DEFENSE (INSTALLATIONS AND LOGISTICS).

DTIC Science & Technology

Fringe effects of value engineering. A survey prepared by the technical subcommittee, AOA special committee on value engineering for the office of the assistant secretary of defense (installations and logistics).

Mobilization and Defense Management Technical Reports Series. A Framework for Increasing Defense Production by Reducing Perceived Opportunity Costs.

DTIC Science & Technology

1983-05-01

advertising. Traditionally defense marketing and advertising focused on decision makers within the defense conuunity and Congress. While it appears that...focus may be- starting to change, marketing and advertising remain highly directed and concentrated in defense oriented media. marketing was oriented to

32 CFR 249.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Definitions. 249.3 Section 249.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.3 Definitions. Contracted...

32 CFR 249.5 - Procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... papers and (1) Inform the author that the Department of Defense has no objection to public presentation... proceedings and/or reprints of papers sponsored by the Department of Defense for all scientific and technical... Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION...

32 CFR 249.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Definitions. 249.3 Section 249.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.3 Definitions. Contracted...

32 CFR 249.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Definitions. 249.3 Section 249.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.3 Definitions. Contracted...

32 CFR 249.5 - Procedures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... papers and (1) Inform the author that the Department of Defense has no objection to public presentation... proceedings and/or reprints of papers sponsored by the Department of Defense for all scientific and technical... Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION...

32 CFR 249.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Definitions. 249.3 Section 249.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.3 Definitions. Contracted...

32 CFR 249.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Definitions. 249.3 Section 249.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.3 Definitions. Contracted...

32 CFR 249.5 - Procedures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... papers and (1) Inform the author that the Department of Defense has no objection to public presentation... proceedings and/or reprints of papers sponsored by the Department of Defense for all scientific and technical... Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION...

76 FR 21809 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-19

... Defense Logistics Agency. [cir] 252.216-7004. Provides needed editorial changes in the clause number in... ``Defense Logistics Agency'' in the definition of ``contracting activity'' to read as follows: 202.101 Definitions. * * * * * Contracting activity * * * Defense Logistics Agency DLA Acquisition (J-7) DLA Aviation...

Radiological Defense. Textbook.

ERIC Educational Resources Information Center

Defense Civil Preparedness Agency (DOD), Washington, DC.

This textbook has been prepared under the direction of the Defense Civil Preparedness Agency (DCPA) Staff College for use as a student reference manual in radiological defense (RADEF) courses. It provides much of the basic technical information necessary for a proper understanding of radiological defense and summarizes RADEF planning and expected…

32 CFR 249.6 - Responsibilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Responsibilities. 249.6 Section 249.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.6 Responsibilities. (a) The Under...

32 CFR 249.6 - Responsibilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 249.6 Section 249.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.6 Responsibilities. (a) The Under...

32 CFR 249.6 - Responsibilities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Responsibilities. 249.6 Section 249.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.6 Responsibilities. (a) The Under...

32 CFR 249.6 - Responsibilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Responsibilities. 249.6 Section 249.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.6 Responsibilities. (a) The Under...

32 CFR 249.6 - Responsibilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Responsibilities. 249.6 Section 249.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.6 Responsibilities. (a) The Under...

2017 Military Investigation and Justice Experience Survey: Overview Report

DTIC Science & Technology

2018-04-30

2016–2017 Military Investigation and Justice Experience Survey (MIJES) Overview Report Additional copies of this report may be obtained...www.dtic.mil/dtic/order.html OPA Report No. 2017-027 January 2018 2016–2017 Military Investigation and Justice Experience Survey (MIJES...Investigation and Justice Experience Survey (MIJES) ii Acknowledgments Acknowledgments The Office of People Analytics (OPA) is indebted to numerous

22 CFR 125.9 - Filing of licenses and other authorizations for exports of classified technical data and...

Code of Federal Regulations, 2010 CFR

2010-04-01

... Defense Trade Controls to the Defense Security Service of the Department of Defense in accordance with the provisions of the Department of Defense National Industrial Security Program Operating Manual (unless such... a copy of the license to the applicant for the applicant's information. The Defense Security Service...

The Potential Transfer of Industrial Skills from Defense to Nondefense Industries. Volume II, Technical Appendix.

ERIC Educational Resources Information Center

California State Dept. of Employment, Sacramento.

This study of skill transferability between missile production and nondefense industries provides the necessary data to help formulate retraining and other programs designed to help workers adjust to cutbacks in defense spending. This technical appendix to the project report contains the data upon which the report's conclusions are based. The…

Broad Overview of Energy Efficiency and Renewable Energy Opportunities for Department of Defense Installations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, E.; Antkowiak, M.; Butt, R.

The Strategic Environmental Research and Developmental Program (SERDP)/Environmental Security Technology Certification Program (ESTCP) is the Department of Defense?s (DOD) environmental science and technology program focusing on issues related to environment and energy for the military services. The SERDP/ESTCP Office requested that the National Renewable Energy Laboratory (NREL) provide technical assistance with strategic planning by evaluating the potential for several types of renewable energy technologies at DOD installations. NREL was tasked to provide technical expertise and strategic advice for the feasibility of geothermal resources, waste-to-energy technology, photovoltaics (PV), wind, microgrids, and building system technologies on military installations. This technical report ismore » the deliverable for these tasks.« less

DTIC 2010 Conference: Celebrating 65 Years of Providing Access to Defense Information. Held in Alexandria, Virginia on March 22-24, 2010

DTIC Science & Technology

2010-03-24

Training Objectives:     Refresh  your knowledge of crucial factors affecting protection and release of con‐ trolled information to non‐U.S. citizens...2009, in Washington, DC. The room was packed and not all had the op‐ portunity to learn details about the  bread ‐and‐butter tools used daily in Military...details about the  bread ‐ and‐butter tools used daily in military research libraries.   Venturing into this brave new realm requires  savvy, time, and

Ipilimumab for Previously Untreated Unresectable Malignant Melanoma: A Critique of the Evidence.

PubMed

Giannopoulou, Christina; Sideris, Eleftherios; Wade, Ros; Moe-Byrne, Thirimon; Eastwood, Alison; McKenna, Claire

2015-12-01

The National Institute for Health and Care Excellence (NICE) invited the manufacturer of ipilimumab (Bristol-Myers Squibb Pharmaceuticals Limited) to submit clinical and cost-effectiveness evidence for previously untreated advanced (unresectable or metastatic) melanoma as part of the Institute's Single Technology Appraisal process. The Centre for Reviews and Dissemination and Centre for Health Economics at the University of York were commissioned to act as the independent Evidence Review Group (ERG). This article presents a summary of the manufacturer's submission of ipilimumab, the ERG review and the resulting NICE guidance TA319, issued in July 2014. Ipilimumab at a recommended dose of 3 mg/kg monotherapy was previously granted marketing authorisation by the European Medicines Agency in adult patients who had received prior therapy and was recommended by NICE in guidance TA268. In October 2013, the EMA approved the extension of this indication to previously untreated advanced melanoma patients. NICE decisions are bound by the marketing authorisation; therefore, the decision problem faced by the NICE Appraisal Committee was whether ipilimumab at a recommended dose of 3 mg/kg monotherapy was effective and cost effective compared with first-line standard of care involving dacarbazine (DTIC) and vemurafenib (for BRAF V600 mutation-positive patients). The CA184-024 trial was the primary source of clinical evidence for ipilimumab. However, this was based on a dose of 10 mg/kg with concomitant DTIC. The results over a 5-year period indicated that ipilimumab 10 mg/kg plus DTIC demonstrated a significant increase in median overall survival (OS) of 2.1 months compared with DTIC plus placebo (11.2 vs. 9.1 months). The BRIM-3 trial, which was an open-label randomised controlled trial (RCT) in BRAF V600 mutation-positive patients, was the primary source of evidence for an indirect comparison with vemurafenib. The results showed that vemurafenib increased median OS by 3.6 months compared with DTIC (13.2 vs. 9.6 months). The economic evaluation compared the costs and outcomes of ipilimumab by assuming that the 3 mg/kg dosing regimen was clinically equivalent in efficacy to an ipilimumab 10 mg/kg dosing regimen plus DTIC and by using a treatment sequencing approach that incorporated second-line active therapy and third-line best supportive care (BSC). In the first appraisal meeting, the committee recommended ipilimumab only in the context of research as part of a clinical study. This was primarily based on the lack of robust evidence to support the assumption of clinical equivalence between dosages and the absence of evidence available to inform the sequential use of treatments. Following the consultation, the manufacturer submitted additional analyses and evidence to support the cost effectiveness of ipilimumab at first line. The manufacturer's response was based on concerns relating to uncertainty surrounding the relative efficacy of ipilimumab 3 mg/kg monotherapy compared with DTIC and vemurafenib, comparability of the patient populations at first and second line, and the effects of concomitant DTIC. These additional analyses indicated that the incremental cost-effectiveness ratio (ICER) was £ 47,900 per quality-adjusted life-year (QALY) gained for ipilimumab compared with DTIC and £ 28,600 per QALY gained for ipilimumab compared with vemurafenib. Following consideration of the additional evidence and the responses from a large number of consultees and commentators, the committee recommended ipilimumab as an option for adults with previously untreated advanced melanoma.

22 CFR 120.6 - Defense article.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Defense article. 120.6 Section 120.6 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.6 Defense article. Defense article means any item or technical data designated in § 121.1 of this subchapter...

22 CFR 120.6 - Defense article.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Defense article. 120.6 Section 120.6 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.6 Defense article. Defense article means any item or technical data designated in § 121.1 of this subchapter...

22 CFR 120.6 - Defense article.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Defense article. 120.6 Section 120.6 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.6 Defense article. Defense article means any item or technical data designated in § 121.1 of this subchapter...

22 CFR 120.6 - Defense article.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Defense article. 120.6 Section 120.6 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.6 Defense article. Defense article means any item or technical data designated in § 121.1 of this subchapter...

22 CFR 120.6 - Defense article.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Defense article. 120.6 Section 120.6 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.6 Defense article. Defense article means any item or technical data designated in § 121.1 of this subchapter...

77 FR 56743 - Federal Acquisition Regulation; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-13

... Regulation; Technical Amendments AGENCY: Department of Defense (DoD), General Services Administration (GSA... publication schedules. Please cite FAC 2005-61, Technical Amendments. SUPPLEMENTARY INFORMATION: In order to...

78 FR 6191 - Federal Acquisition Regulation; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-29

... Regulation; Technical Amendments AGENCY: Department of Defense (DoD), General Services Administration (GSA... publication schedules. Please cite FAC 2005-65, Technical Amendments. SUPPLEMENTARY INFORMATION: In order to...

2016 Military Investigation and Justice Experience Survey: Overview Report

DTIC Science & Technology

2017-05-01

2016 Military Investigation and Justice Experience Survey (MIJES) Overview Report Additional copies of this report may be obtained from...dtic/order.html Ask for report by DTIC # OPA Report No. 2017-003 March 2017 2016 MILITARY INVESTIGATION AND JUSTICE EXPERIENCE SURVEY (MIJES...Justice Experience Survey (MIJES) 2017 ii | OPA Acknowledgments The Office of People Analytics (OPA) is indebted to numerous people for their

FY 2002 Customer Satisfaction & Top 200 Users Survey Composite Report

DTIC Science & Technology

2002-11-01

Federal Government Benchmark 68.6% 71.1% DTIC Excels by +8.4 +11 *ACSI is the official service quality benchmark for the...care. § The American Customer Satisfaction Index (ACSI), the official service quality benchmark for the Federal Government, is currently 71.1%; DTIC...ACSI is the official service quality benchmark for the Federal GovernmentFig 1FY 20020Comparison of Customer Satisfaction (Customer Care

Identity Crisis between the Wars: How Doctrine Shaped the Marine Corps after World War I and Vietnam

DTIC Science & Technology

2017-06-21

in search of a new role, after decades as a constabulary force in the so-called Banana Wars and then its experience in World War I as very nearly...Officer (thesis, Marine Corps University, 2008), http://www.dtic.mil/dtic/tr/fulltext/u2/a492168.pdf; and Maj Collin A. Agee (USA), Peeling The Onion

Information Operations and Public Affairs: A Union of Influence

DTIC Science & Technology

2012-03-22

Information Operations,” (Quantico VA: United States Marine Corps, May 15, 1998) http://www.dtic.mil/dtic/tr/fulltext/u2/a400016.pdf (accessed December 11...Information Operations and Public Affairs: A Union of Influence by Lieutenant Colonel Duane A. Opperman United States Marine ...inform and influence audiences, gaps may exist. Both public affairs and information operations have defined mission sets and are necessarily separated

32 CFR 203.10 - Eligible activities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... with technical reports that summarize data and support cleanup decisions. Technical assistance may be provided to review plans and interpret technical reports for community members of RABs and TRCs. These...) MISCELLANEOUS TECHNICAL ASSISTANCE FOR PUBLIC PARTICIPATION (TAPP) IN DEFENSE ENVIRONMENTAL RESTORATION...

32 CFR 203.10 - Eligible activities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... with technical reports that summarize data and support cleanup decisions. Technical assistance may be provided to review plans and interpret technical reports for community members of RABs and TRCs. These...) MISCELLANEOUS TECHNICAL ASSISTANCE FOR PUBLIC PARTICIPATION (TAPP) IN DEFENSE ENVIRONMENTAL RESTORATION...

32 CFR 203.10 - Eligible activities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... with technical reports that summarize data and support cleanup decisions. Technical assistance may be provided to review plans and interpret technical reports for community members of RABs and TRCs. These...) MISCELLANEOUS TECHNICAL ASSISTANCE FOR PUBLIC PARTICIPATION (TAPP) IN DEFENSE ENVIRONMENTAL RESTORATION...

Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma.

PubMed

Yamazaki, N; Uhara, H; Fukushima, S; Uchi, H; Shibagaki, N; Kiyohara, Y; Tsutsumida, A; Namikawa, K; Okuyama, R; Otsuka, Y; Tokudome, T

2015-11-01

Ipilimumab (IPI), a monoclonal antibody against immune-checkpoint receptor cytotoxic T lymphocyte antigen-4, is designed to enhance antitumor T cell function. IPI 10 mg/kg plus dacarbazine (DTIC) significantly improved overall survival in a phase 3 study involving predominantly Caucasian patients, with an adverse event (AE) profile similar to that of IPI monotherapy. We conducted a single-arm, phase 2 study to evaluate the safety and efficacy of IPI plus DTIC in Japanese patients. Previously untreated patients with unresectable stage III or IV melanoma received IPI 10 mg/kg plus DTIC 850 mg/m(2) every 3 weeks for four doses (q3w × 4), followed by DTIC q3w × 4 and then IPI every 12 weeks until disease progression or intolerable toxicity. All 15 treated patients reported drug-related AEs, the most common of which were increases in alanine aminotransferase (n = 12, 80 %) and aspartate aminotransferase (n = 11, 73 %). Treatment-related serious AEs were reported in 11 (73 %) patients. Nine patients (60 %) discontinued treatment due to drug-related toxicities. Immune-related AEs (irAEs) were reported in 14 patients (93 %). The most frequent irAEs were liver (n = 12, 80 %) and skin (n = 10, 67 %) toxicities. Five deaths were reported; all were caused by progressive disease. Efficacy evaluation showed one complete response, one partial response and four patients with stable disease. Best overall response rate was 13 % (2/15), and the disease control rate was 40 % (6/15). The study was terminated early due to frequent, high-grade liver toxicities. IPI 10 mg/kg plus DTIC 850 mg/m(2) was not considered tolerable in the Japanese patient population. ClinicalTrials.gov identifier: NCT01681212.

32 CFR 37.895 - How is the final performance report to be sent to the Defense Technical Information Center?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Award Terms Related to Other Administrative Matters Financial and Programmatic Reporting § 37.895...

Combating Terrorism with Preparation of the Battlespace

DTIC Science & Technology

2003-04-01

and theater levels. 49 Ibid. For the Department of State official counterterrorist policy, see: Colin Powell, “U.S. Counterterrorism Policy...15 November 2002; James Bamford , “How to (De-)Centralize Intelligence,” New York Times, 24 November 2002, available from <http://ebird.dtic.mil...Angeles Times, 27 October 2002. Available from <http://ebird.dtic.mil/Oct2002/e20021028secret.html> Internet. Accessed 28 October 2002. Bamford

A Spoken English Recognition Expert System.

DTIC Science & Technology

1983-09-01

Davidson. "Representation of Knowledge," Handbook of Artificial Intelligence, edited by Avron Barr and Edward A. Felgenbaum. DTIC document number AD...Regents of the University of CalTorni, 1981. 9. Gardner, Anne. "Search," Handbook of Artificial Intelligence, edited by Avron Barr and Edward A...Felgenbaum, DTIC document number AD A074078, 1979. 10. Gardner, Anne,et al. "Natural Language Understanding," Handbook of Artificial Intelligence, edited

Chemotherapy of Rodent Malaria. Part 1.

DTIC Science & Technology

1986-09-01

r-.-n r ri it ,i n’ reat u i m t. i u r , o , eck f ’ aIny b: e interfe r e ,r.r Orn t tn. - References: 1. Mii l , * ii,? ta’,on . . .. (1d85) rd . i...Center (DTIC) ATTN: DTIC-DDAC Cameron Station Alexandria, VA 22304-6145 copy jen .cf ool of Miedicine ninformed Servies Univercit, of the H,-1it

Enhanced anti-tumor activity by the combination of a conditionally replicating adenovirus mediated interleukin-24 and dacarbazine against melanoma cells via induction of apoptosis.

PubMed

Jiang, Guan; Liu, Yan-Qun; Wei, Zhi-Ping; Pei, Dong-Sheng; Mao, Li-Jun; Zheng, Jun-Nian

2010-08-28

Malignant melanoma is one of the most lethal and aggressive human malignancies. It is notoriously resistant to all of the current therapeutic modalities, including chemotherapy. Suppressed apoptosis and extraordinary invasiveness are the distinctive features that contribute to the malignancy of melanoma. Dacarbazine (DTIC) has been considered as the gold standard for melanoma treatment with a response rate of 15-20%. Unfortunately, the resistance to this chemotherapeutic agent occurs frequently. ZD55-IL-24 is a selective conditionally replicating adenovirus that can mediate the expression of interleukin-24 (IL-24) gene, which has a strong anti-tumor effect. In this study, we hypothesized that a combination of ZD55-IL-24-mediated gene virotherapy and chemotherapy using DTIC would produce an increased cytotoxicity against human melanoma cells in comparison with these agents alone. Our results showed that the combination of ZD55-IL-24 and DTIC significantly enhanced the anti-tumor activity by more effectively inducing apoptosis in melanoma cells than either agent used alone without any overlapping toxicity against normal cells. This additive or synergistic effect of ZD55-IL-24 in combination with DTIC in killing human malignant melanoma cells implies a promising novel approach for melanoma therapy. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

Tailoring and Critical Thinking - Key Principles for Acquisition Success

DTIC Science & Technology

2015-10-01

Defense AT&L: September–October 2015 6 Tailoring and Critical Thinking— Key Principles for Acquisition Success Mike Kotzian, D.M. n Michael Paul...well as program success . 7 Defense AT&L: September–October 2015 The Long Range Anti-Ship Missile Opportunity To ensure DARPA maintains its ability... successful flight demonstra- tions that initially proved the technical approach. Concurrent with these technical accomplishments came two important

Department of Energy Actions Necessary to Improve DOE’s Training Program

DTIC Science & Technology

1999-02-01

assessments, the Department has completed analyses and implemented training programs for the defense nuclear facilities technical workforce and...certification standards, such as those examined by the Defense Nuclear Facilities Safety Board in its reviews of Department operations, impose... nuclear facilities will have their technical skills assessed and will receive continuing training to maintain certain necessary skills. Page 17 GAO/RCED

75 FR 18937 - Bureau of Political-Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-13

... transfer of defense articles, including technical data, and defense services for the manufacture of Small Diameter Bomb Increment I (SDB I) Weapon System in Italy for end-use by the Italian Air Force. The United...

77 FR 14007 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-08

... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Meeting Notice Federal Register CITATION OF... THE MEETING: The Defense Nuclear Facilities Safety Board (Board) is expanding the matters to be.../ resolution of safety and technical issues across the defense nuclear facilities complex. Since this panel...

77 FR 40140 - Bureau of Political-Military Affairs; Statutory Debarment of Pratt & Whitney Canada Corporation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... for the export of defense articles or defense services where the applicant, or any party to the export... indirectly in the export of defense articles, including technical data, or in the furnishing of defense... only after a full review of all circumstances, paying particular attention to the following factors...

48 CFR 212.211 - Technical data.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Technical data. 212.211 Section 212.211 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT... Acquisition of Commercial Items 212.211 Technical data. The DoD policy for acquiring technical data for...

48 CFR 212.211 - Technical data.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Technical data. 212.211 Section 212.211 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT... Acquisition of Commercial Items 212.211 Technical data. The DoD policy for acquiring technical data for...

48 CFR 212.211 - Technical data.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Technical data. 212.211 Section 212.211 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT... Acquisition of Commercial Items 212.211 Technical data. The DoD policy for acquiring technical data for...

48 CFR 212.211 - Technical data.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Technical data. 212.211 Section 212.211 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT... Acquisition of Commercial Items 212.211 Technical data. The DoD policy for acquiring technical data for...

48 CFR 212.211 - Technical data.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Technical data. 212.211 Section 212.211 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT... Acquisition of Commercial Items 212.211 Technical data. The DoD policy for acquiring technical data for...

Radiation Belt Dynamics

DTIC Science & Technology

2015-12-27

is unlimited. 15 DISTRIBUTION LIST DTIC/OCP 8725 John J. Kingman Rd, Suite 0944 Ft Belvoir, VA 22060-6218 1 cy AFRL /RVIL Kirtland AFB, NM 87117... AFRL -RV-PS- AFRL -RV-PS- TR-2016-0007 TR-2016-0007 RADIATION BELT DYNAMICS Jay M. Albert, et al. 27 December 2015 Final Report APPROVED FOR... KIRTLAND AIR FORCE BASE, NM 87117-5776 DTIC COPY NOTICE AND SIGNATURE PAGE Using Government drawings, specifications, or other data included in this

HTB140 melanoma cells under proton irradiation and/or alkylating agents

NASA Astrophysics Data System (ADS)

Korićanac, L.; Petrović, I.; Privitera, G.; Cuttone, G.; Ristić-Fira, A.

2007-09-01

Chemoresistance is a major problem in the treatment of malignant melanoma. The mainstay of treatment for melanoma is the DNA-alkylating agent dacarbazine (DTIC). Fotemustine (FM), a member of the chloroethylnitrosourea group of alkylating agents, has also demonstrated significant antitumor effects in malignant melanoma. However, the intrinsic and acquired resistance of melanoma limits the clinical application of these drugs. Melanomas are also extremely radioresistant. With the objective of enhancing growth inhibition of melanoma cells, combined treatments of FM or DTIC with proton irradiation have been investigated. These effects were studied on HTB140 melanoma cell viability and proliferation. Cells exposed to treatment with FM and protons have shown inhibition of cell growth and significant reduction of proliferation capacity compared to single irradiation or drug treatment. Treatment with DTIC and protons has shown improved growth inhibition compared to appropriate single drug treatment, while the effects of single proton irradiation have been the most pronounced.

22 CFR 125.2 - Exports of unclassified technical data.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., visual or documentary disclosure of technical data by U.S. persons to foreign persons. A license is... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exports of unclassified technical data. 125.2... THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.2 Exports of unclassified technical...

22 CFR 125.2 - Exports of unclassified technical data.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., visual or documentary disclosure of technical data by U.S. persons to foreign persons. A license is... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Exports of unclassified technical data. 125.2... THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.2 Exports of unclassified technical...

22 CFR 125.2 - Exports of unclassified technical data.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., visual or documentary disclosure of technical data by U.S. persons to foreign persons. A license is... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Exports of unclassified technical data. 125.2... THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.2 Exports of unclassified technical...

22 CFR 125.2 - Exports of unclassified technical data.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., visual or documentary disclosure of technical data by U.S. persons to foreign persons. A license is... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Exports of unclassified technical data. 125.2... THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.2 Exports of unclassified technical...

Defense of Defense Human Factors Engineering Technical Advisory Group Meeting Summary

DTIC Science & Technology

2012-07-01

Survivability ( Plaga ) • Wright, N; OSD and DSOC Helicopter Seating Studies Zehner, G; An Overview of USAF Anthropometry Plaga , J & Hill; SAFE Association...predictions. – 1230 - 1430 Standardization - 1472H (Poston) – 1230 - 1430 Human Factors in Extreme Environments & SS ( Plaga ) • Ganey, HCN...Classification (Personnel) LT Chris Foster Dr. Hector Acosta System Safety/Health Hazards/ Survivability (SS/HH/Sv) Mr. John Plaga Technical Society

32 CFR 203.10 - Eligible activities.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) MISCELLANEOUS TECHNICAL ASSISTANCE FOR PUBLIC PARTICIPATION (TAPP) IN DEFENSE ENVIRONMENTAL RESTORATION... at the facility do not have the necessary technical expertise for the proposed project, or the proposed technical assistance will contribute to the efficiency, effectiveness, or timeliness of...

77 FR 23631 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-20

..., 217, 242, 245, and 252 Government procurement. Mary Overstreet, Editor, Defense Acquisition... ``Deputy Assistant Secretary of the Army (Procurement)'' in alphabetical order; 0 b. In the Army list by... purchase, travel, and fuel card programs is available in the ``Department of Defense Government Charge Card...

32 CFR 28.300 - Professional and technical services.

Code of Federal Regulations, 2010 CFR

2010-07-01

... and technical services” shall be limited to advice and analysis directly applying any professional or... and analysis directly applying their professional or technical expertise and unless the advice or... 32 National Defense 1 2010-07-01 2010-07-01 false Professional and technical services. 28.300...

32 CFR 28.205 - Professional and technical services.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., “professional and technical services” shall be limited to advice and analysis directly applying any professional... provide advice and analysis directly applying their professional or technical expertise and unless the... 32 National Defense 1 2010-07-01 2010-07-01 false Professional and technical services. 28.205...

32 CFR 28.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., “professional and technical services” shall be limited to advice and analysis directly applying any professional... provide advice and analysis directly applying their professional or technical expertise and unless the... 32 National Defense 1 2011-07-01 2011-07-01 false Professional and technical services. 28.205...

77 FR 13013 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-05

... Organization Government Procurement Agreement and the Free Trade Agreements, as determined by the United States... 252 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System...

22 CFR 120.9 - Defense service.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., educational, or information publications and media of all kinds, training aid, orientation, training exercise..., destruction, processing or use of defense articles; (2) The furnishing to foreign persons of any technical...

22 CFR 120.9 - Defense service.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., educational, or information publications and media of all kinds, training aid, orientation, training exercise..., destruction, processing or use of defense articles; (2) The furnishing to foreign persons of any technical...

22 CFR 120.9 - Defense service.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., educational, or information publications and media of all kinds, training aid, orientation, training exercise..., destruction, processing or use of defense articles; (2) The furnishing to foreign persons of any technical...

22 CFR 120.9 - Defense service.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., educational, or information publications and media of all kinds, training aid, orientation, training exercise..., destruction, processing or use of defense articles; (2) The furnishing to foreign persons of any technical...

76 FR 20800 - Bureau of Political-Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

..., certification of a proposed manufacturing license agreement for the manufacture of significant military..., certification of a proposed manufacturing license agreement for the manufacture of significant military... transfer of defense articles, to include technical data, and defense services to support the design...

76 FR 30751 - Bureau of Political-Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-26

... transmitting, herewith, certification of a proposed manufacturing license agreement for the manufacture of... services to support the design, manufacture and delivery of the Es'Hail Satellite Program. The United... defense articles, including technical data, and defense services to support the design, manufacture...

22 CFR 125.3 - Exports of classified technical data and classified defense articles.

Code of Federal Regulations, 2010 CFR

2010-04-01

... in the Department of Defense National Industrial Security Program Operating Manual (unless such.... It should also list the facility security clearance code of all U.S. parties on the license and include the Defense Security Service cognizant security office of the party responsible for packaging the...

77 FR 58437 - 30-Day Notice of Proposed Information Collections: Two Directorate of Defense Trade Controls...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-20

.... Attention: Desk Officer for Department of State. FOR FURTHER INFORMATION CONTACT: Direct requests for... proposed collection: The export, temporary import, temporary export and brokering of defense articles... articles, defense services, and related technical data, or the brokering thereof, must register with the...

32 CFR Appendix A to Part 516 - References

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 3 2014-07-01 2014-07-01 false References A Appendix A to Part 516 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC... can be obtained at the National Technical Information Services, U.S. Department of Commerce, 5285 Port...

Naval Training Device Center Index of Technical Reports.

ERIC Educational Resources Information Center

Walker, Lemuel E.

Published Naval Training Device Center technical reports and some technical notes (those available through the Defense Documentation Center-DDC) which have resulted from basic research, exploratory development, and advanced development type projects are listed. The reports are indexed by technical note number, by title, and by contractor code. The…

22 CFR 124.6 - Termination of manufacturing license agreements and technical assistance agreements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... and technical assistance agreements. 124.6 Section 124.6 Foreign Relations DEPARTMENT OF STATE... Termination of manufacturing license agreements and technical assistance agreements. The U.S. party to a manufacturing license or a technical assistance agreement must inform the Directorate of Defense Trade Controls...

78 FR 21850 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

... Parts 215, 235, and 237 Government procurement. Manuel Quinones, Editor, Defense Acquisition Regulations...-79 for notifying affected incumbent contractors of Government in-sourcing actions, in accordance with...

A Modest Proposal: Permit Interlocutory Appeals of Summary Judgment Denials

DTIC Science & Technology

1994-04-01

DTIC.FDAC DTIC 70A DOCaum~ ROCESS INr GAT NB •LD U•E RTONK LOAN DOCUMENT Best Availab le Copy A MODEST PROPOSAL: PERMIT INTERLOCUTORY APPEALS OF SUMMARY...PERMIT INTERLOCUTORY APPEALS OF SUMMARY JUDGMENT DENIALS Michael J. Davidson Major, U.S. Army Judge Advocate General’s Corps ABSTRACT: In 1986, the... interpreting Rule 56 of the Federal Rules of Civil Procedure, discusses the shortcomings of potential avenues of appeal , and suggests two methods by which

Social Moderation and Dynamic Elements in Crowdsourced Geospatial Data: A Report on Quality Assessment, Dynamic Extensions and Mobile Device Engagement in the George Mason University Geocrowdsourcing Testbed

DTIC Science & Technology

2015-11-01

GMU) Associate Professor Dieter Pfoser describes an explosion of user generated content (UGC) available over the Internet (Pfoser 2011, Crooks et al...Crowdsourced and User - Generated Geospatial Data,” Annual (Fairfax, VA: George Mason University, November 29, 2012), http://www.dtic.mil/dtic/tr/fulltext/u2...area include GPS-enabled geosocial and 34 Dieter Pfoser, “On User - Generated

Research Abstracts of 1980.

DTIC Science & Technology

1980-12-01

ABSTRACTS OF 1980. 9 - DTIC ELECTEf ii S AN3O 1981j _NAVAL DISTRIBUTION SMT:MIT DENTAL RESEARCH Approved for PUbDiC T INSTITE iii~2 YA3 It81 Naval...Medical Research apd Development Command 30 £ Bethesda, Maryland ( *- i - NTIS - GRA&I DTIC TAB - Urrannouneed NAVAL DENTAL RESEARCH INSTITUTE...r1 w American Assoctat/ion for Dental Research, 58th Annual Session, Los Angeles, California, March 20-23, 1980. 1. AV6ERSON*, D. N., LANGELAND, K

Dacarbazine treatment before peptide vaccination enlarges T-cell repertoire diversity of melan-a-specific, tumor-reactive CTL in melanoma patients.

PubMed

Palermo, Belinda; Del Bello, Duilia; Sottini, Alessandra; Serana, Federico; Ghidini, Claudia; Gualtieri, Novella; Ferraresi, Virginia; Catricalà, Caterina; Belardelli, Filippo; Proietti, Enrico; Natali, Pier Giorgio; Imberti, Luisa; Nisticò, Paola

2010-09-15

Combination of chemotherapy and immunotherapy to increase the effectiveness of an antitumor immune response is currently regarded as an attractive antitumor strategy. In a pilot clinical trial, we have recently documented an increase of melanoma antigen A (Melan-A)-specific, tumor-reactive, long-lasting effector-memory CD8(+) T cells after the administration of dacarbazine (DTIC) 1 day before peptide vaccination in melanoma patients. Global transcriptional analysis revealed a DTIC-induced activation of genes involved in the immune response and leukocyte activation. To identify the possible mechanisms underlying this improved immune response, we have compared the endogenous and the treatment-induced anti-Melan-A response at the clonal level in patients treated with the vaccine alone or with DTIC plus vaccine. We report a progressive widening of T-cell receptor (TCR) repertoire diversity, accompanied by high avidity and tumor reactivity, only in Melan-A-specific T-cell clones of patients treated with chemoimmunotherapy, with a trend toward longer survival. Differently, patients treated with vaccine alone showed a tendency to narrowing the TCR repertoire diversity, accompanied by a decrease of tumor lytic activity in one patient. Collectively, our findings indicate that DTIC plus vaccination shapes the TCR repertoire in terms of diversity and antitumor response, suggesting that this combined therapy could be effective in preventing melanoma relapse. ©2010 AACR.

Curcumin analog DM-1 in monotherapy or combinatory treatment with dacarbazine as a strategy to inhibit in vivo melanoma progression.

PubMed

Faião-Flores, Fernanda; Quincoces Suarez, José Agustín; Fruet, Andréa Costa; Maria-Engler, Silvya Stuchi; Pardi, Paulo Celso; Maria, Durvanei Augusto

2015-01-01

Malignant melanoma is a highly aggressive form of skin cancer with a high mortality rate if not discovered in early stages. Although a limited number of treatment options for melanoma currently exist, patients with a more aggressive form of this cancer frequently decline treatment. DM-1 is a sodium phenolate and curcumin analog with proven anticancer, anti-proliferative and anti-metastatic properties. In this paper, the DM-1 compound showed in vivo antitumor activity alone or in combination with chemotherapeutic DTIC in B16F10 melanoma-bearing mice. Beneficial effects such as melanoma tumor burden reduction with pyknotic nuclei, decreased nuclei/cytoplasmic ratio and nuclear degradation occurred after DM-1 treatment. No toxicological changes were observed in the liver, kidneys, spleen and lungs after DM-1 monotherapy or DTIC combined therapy. DTIC+DM-1 treatment induced the recovery of anemia arising from melanoma and immunomodulation. Both DM-1 treatment alone and in combination with DTIC induced apoptosis with the cleavage of caspase-3, -8 and -9. Furthermore, melanoma tumors treated with DM-1 showed a preferential apoptotic intrinsic pathway by decreasing Bcl-2/Bax ratio. Considering the chemoresistance exhibited by melanoma towards conventional chemotherapy drugs, DM-1 compound in monotherapy or in combination therapy provides a promising improvement in melanoma treatment with a reduction of side effects.

Q-TWiST analysis comparing ipilimumab/dacarbazine vs placebo/dacarbazine for patients with stage III/IV melanoma.

PubMed

Sherrill, B; Wang, J; Kotapati, S; Chin, K

2013-07-09

Study CA184024 was a multinational, randomised, double-blind, phase 3 study comparing ipilimumab/dacarbazine (DTIC) vs placebo/DTIC in patients with untreated stage III/IV melanoma, which showed that ipilimumab significantly improves survival in patients with metastatic melanoma. The objective of this analysis was to compare the quality-adjusted survival experience among patients in this trial. Survival time was partitioned into health states: toxicity, time before progression without toxicity, and relapse until death or end of follow-up. Q-TWiST (quality-adjusted time without symptoms of disease or toxicity of treatment) was calculated as the utility-weighted sum of the mean health state durations. Analyses were repeated over extended follow-up periods. Based on a combination of trial-based and external utility scores, the Q-TWiST difference in this trial was 0.50 months (P=0.0326) favoring ipilimumab after 1 year. The Q-TWiST difference was 1.5 months with 2 years of follow-up (P=0.0091), 2.36 months at 3 years (P=0.005) and 3.28 months at 4 years (P=0.0074). During the first year of study, there was little difference between groups in quality-adjusted survival. However, after 2, 3 and 4 years follow-up for patients with extended survival, the benefits of IPI+DTIC vs PLA+DTIC for advanced melanoma continue to accrue.

Curcumin Analog DM-1 in Monotherapy or Combinatory Treatment with Dacarbazine as a Strategy to Inhibit In Vivo Melanoma Progression

PubMed Central

Faião-Flores, Fernanda; Quincoces Suarez, José Agustín; Fruet, Andréa Costa; Maria-Engler, Silvya Stuchi; Pardi, Paulo Celso; Maria, Durvanei Augusto

2015-01-01

Malignant melanoma is a highly aggressive form of skin cancer with a high mortality rate if not discovered in early stages. Although a limited number of treatment options for melanoma currently exist, patients with a more aggressive form of this cancer frequently decline treatment. DM-1 is a sodium phenolate and curcumin analog with proven anticancer, anti-proliferative and anti-metastatic properties. In this paper, the DM-1 compound showed in vivo antitumor activity alone or in combination with chemotherapeutic DTIC in B16F10 melanoma-bearing mice. Beneficial effects such as melanoma tumor burden reduction with pyknotic nuclei, decreased nuclei/cytoplasmic ratio and nuclear degradation occurred after DM-1 treatment. No toxicological changes were observed in the liver, kidneys, spleen and lungs after DM-1 monotherapy or DTIC combined therapy. DTIC+DM-1 treatment induced the recovery of anemia arising from melanoma and immunomodulation. Both DM-1 treatment alone and in combination with DTIC induced apoptosis with the cleavage of caspase-3, -8 and -9. Furthermore, melanoma tumors treated with DM-1 showed a preferential apoptotic intrinsic pathway by decreasing Bcl-2/Bax ratio. Considering the chemoresistance exhibited by melanoma towards conventional chemotherapy drugs, DM-1 compound in monotherapy or in combination therapy provides a promising improvement in melanoma treatment with a reduction of side effects. PMID:25742310

Technical Transfer Report on a TNT Enzyluminescent Vapor Detection System

DTIC Science & Technology

1991-02-01

Library) ATN: DELSD-L Aberdeen Proving Ground , MD 21005 Fort Monouth, NJ 07703-5301 1 Comm er President US Army Aberden Proving Ground US Army Aation Ten...I Director, Technical Information ATTN: AMXSY-MP Defense Advanced Research Projects Agency Aberdeen Proving Ground , MD 21005-5071 1400 Wilson...Blvd.Arlington, VA 22209 1 Director US Ballistics Research Laboratory I Director ATN: AMXBR-OD-ST (STINFO) Defense Nuclear Agency Aberdeen Proving Ground , MD

Our Theme for 2016: Sustaining Momentum

DTIC Science & Technology

2016-03-01

of design architectures and interfaces to make both open sys- tems and modularity a reality. This is “owning the technical baseline,” and the devil... write this year, although we will be implementing the changes required in the Fiscal Year (FY) 2016 National Defense Au- thorization Act. We still...Defense for Acquisition, Technology, and Logistics on the momentum we have gained as we get ready for a new administration next year. Promote Technical

32 CFR Appendix D to Part 286 - DD Form 2086-1, “Record of Freedom of Information (FOI) Processing Cost for Technical Data”

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false DD Form 2086-1, âRecord of Freedom of Information (FOI) Processing Cost for Technical Dataâ D Appendix D to Part 286 National Defense Department of... FREEDOM OF INFORMATION ACT PROGRAM REGULATION Pt. 286, App. D Appendix D to Part 286—DD Form 2086-1...

What to Do About That Pack of Wolves at the Door: A Binational Organization and Acquisitions Approach to Homeland Cruise Missile Defense

DTIC Science & Technology

2016-04-04

land attack cruise missiles (LACMs) within the context of the changing geopolitical environment. The research analyzes the current state of NORAD’s...homeland cruise missile defense apparatus with respect to its organization and technical capability. The principle argument is that land attack cruise...defense for the homeland. 15. SUBJECT TERMS: land attack cruise missiles, cruise missile defense, homeland defense, NORAD, directed energy 16

Toxicities, safeties and clinical response of dacarbazine-based chemotherapy on neuroendocrine tumors in Taiwan population.

PubMed

Chiu, Hwa-Yen; Lin, Liang-Yu; Chou, Wen-Chi; Fang, Wen-Liang; Shyr, Yi-Ming; Yeh, Yi-Chen; Mu-Hsin Chang, Peter; Chen, Ming-Han; Hung, Yi-Ping; Chao, Yee; Chien, Sheng-Hsuan; Chen, Ming-Huang

2018-05-01

Currently, the role of dacarbazine (DTIC) based chemotherapy in neuroendocrine tumors (NETs) in Asia is unclear. Here, we report the outcomes of dacarbazine (DTIC)-based chemotherapy in Taiwan population. DTIC alone (250 mg/m 2 /day), or 5-fluorouracil (5-FU, 500 mg/m 2 /day) and DTIC (200 mg/m 2 /day) with or without epirubicin (200 mg/m 2 /day), for 3 days, every 3-4 weeks. Subgroups were analyzed by grading, and by Ki-67 index. 48 patients were reviewed in this study, including 3 had grade 1 tumors, 23 had grade 2, while 22 were grade 3. In grade 3 NEC patients, the tumor Ki-67 index of 21-55% were noted in 8 patients, and >55% in 14 patients. Progression-free survival (PFS) was 5.1 months, and overall survival (OS) was 31.6 months. The PFS (in months) were 12.5 and 1.8 for patients with NETs and neuroendocrine carcinomas (NECs), respectively (p < 0.001). The OS were not reached and 5.9 months for patients with NETs and NECs, respectively (p = 0.001). Patients with NECs were divided into two groups, according to their Ki-67 index. In patients with a tumor Ki-67 index of 21-55%, PFS was 4.1 months, and OS was not reached; in those with a tumor Ki-67 index of >55%, they were 1.5 and 1.8 months, respectively (p < 0.001 and p = 0.013). NETs, and grade 3 NECs, with Ki-67 indices of 20-55% had good responses to DTIC-based chemotherapy, with acceptable side effects. Ki-67 index could predict prognosis for grade 3 NEC patients, and guide further chemotherapy choices. Copyright © 2017 the Chinese Medical Association. Published by Elsevier Taiwan LLC. All rights reserved.

Effects of fotemustine or dacarbasine on a melanoma cell line pretreated with therapeutic proton irradiation

PubMed Central

Ristić-Fira, Aleksandra M; Korićanac, Lela B; Žakula, Jelena J; Valastro, Lucia M; Iannolo, Gioacchin; Privitera, Giuseppe; Cuttone, Giacomo; Petrović, Ivan M

2009-01-01

Background Considering that HTB140 melanoma cells have shown a poor response to either protons or alkylating agents, the effects of a combined use of these agents have been analysed. Methods Cells were irradiated in the middle of the therapeutic 62 MeV proton spread out Bragg peak (SOBP). Irradiation doses were 12 or 16 Gy and are those frequently used in proton therapy. Four days after irradiation cells were treated with fotemustine (FM) or dacarbazine (DTIC). Drug concentrations were 100 and 250 μM, values close to those that produce 50% of growth inhibition. Cell viability, proliferation, survival and cell cycle distribution were assessed 7 days after irradiation that corresponds to more than six doubling times of HTB140 cells. In this way incubation periods providing the best single effects of drugs (3 days) and protons (7 days) coincided at the same time. Results Single proton irradiations have reduced the number of cells to ~50%. FM caused stronger cell inactivation due to its high toxicity, while the effectiveness of DTIC, that was important at short term, almost vanished with the incubation of 7 days. Cellular mechanisms triggered by proton irradiation differently influenced the final effects of combined treatments. Combination of protons and FM did not improve cell inactivation level achieved by single treatments. A low efficiency of the single DTIC treatment was overcome when DTIC was introduced following proton irradiation, giving better inhibitory effects with respect to the single treatments. Most of the analysed cells were in G1/S phase, viable, active and able to replicate DNA. Conclusion The obtained results are the consequence of a high resistance of HTB140 melanoma cells to protons and/or drugs. The inactivation level of the HTB140 human melanoma cells after protons, FM or DTIC treatments was not enhanced by their combined application. PMID:19358719

Effects of fotemustine or dacarbasine on a melanoma cell line pretreated with therapeutic proton irradiation.

PubMed

Ristić-Fira, Aleksandra M; Korićanac, Lela B; Zakula, Jelena J; Valastro, Lucia M; Iannolo, Gioacchin; Privitera, Giuseppe; Cuttone, Giacomo; Petrović, Ivan M

2009-04-09

Considering that HTB140 melanoma cells have shown a poor response to either protons or alkylating agents, the effects of a combined use of these agents have been analysed. Cells were irradiated in the middle of the therapeutic 62 MeV proton spread out Bragg peak (SOBP). Irradiation doses were 12 or 16 Gy and are those frequently used in proton therapy. Four days after irradiation cells were treated with fotemustine (FM) or dacarbazine (DTIC). Drug concentrations were 100 and 250 microM, values close to those that produce 50% of growth inhibition. Cell viability, proliferation, survival and cell cycle distribution were assessed 7 days after irradiation that corresponds to more than six doubling times of HTB140 cells. In this way incubation periods providing the best single effects of drugs (3 days) and protons (7 days) coincided at the same time. Single proton irradiations have reduced the number of cells to approximately 50%. FM caused stronger cell inactivation due to its high toxicity, while the effectiveness of DTIC, that was important at short term, almost vanished with the incubation of 7 days. Cellular mechanisms triggered by proton irradiation differently influenced the final effects of combined treatments. Combination of protons and FM did not improve cell inactivation level achieved by single treatments. A low efficiency of the single DTIC treatment was overcome when DTIC was introduced following proton irradiation, giving better inhibitory effects with respect to the single treatments. Most of the analysed cells were in G1/S phase, viable, active and able to replicate DNA. The obtained results are the consequence of a high resistance of HTB140 melanoma cells to protons and/or drugs. The inactivation level of the HTB140 human melanoma cells after protons, FM or DTIC treatments was not enhanced by their combined application.

48 CFR 252.205-7000 - Provision of information to cooperative agreement holders.

Code of Federal Regulations, 2013 CFR

2013-10-01

... has an agreement with the Defense Logistics Agency to furnish procurement technical assistance to... defense contracts. The list shall include the business address, telephone number, and area of...

48 CFR 252.205-7000 - Provision of information to cooperative agreement holders.

Code of Federal Regulations, 2010 CFR

2010-10-01

... has an agreement with the Defense Logistics Agency to furnish procurement technical assistance to... defense contracts. The list shall include the business address, telephone number, and area of...

48 CFR 252.205-7000 - Provision of information to cooperative agreement holders.

Code of Federal Regulations, 2014 CFR

2014-10-01

... has an agreement with the Defense Logistics Agency to furnish procurement technical assistance to... defense contracts. The list shall include the business address, telephone number, and area of...

48 CFR 252.205-7000 - Provision of information to cooperative agreement holders.

Code of Federal Regulations, 2011 CFR

2011-10-01

... has an agreement with the Defense Logistics Agency to furnish procurement technical assistance to... defense contracts. The list shall include the business address, telephone number, and area of...

48 CFR 252.205-7000 - Provision of information to cooperative agreement holders.

Code of Federal Regulations, 2012 CFR

2012-10-01

... has an agreement with the Defense Logistics Agency to furnish procurement technical assistance to... defense contracts. The list shall include the business address, telephone number, and area of...

Officer Career Development: Measures and Samples in the 1981-1989 Research Program

DTIC Science & Technology

1991-03-01

and Samples in the 1981-1989 Research Program Gerry L. Wilcove William C . Wilson DTIC S ELECTE APR25 19911 EU Approved for public release: distibution...Wilcove William C . Wilson A oosst~on For NIS GRA&I ’ -DTIC TAB Unannounced Q Just if I cation-,--, Reviewed by Distribution/ Robert F. Morrison...1989 Program Element 0602233N, Research Program Work Unit RM33M20.06 6. AUTHOR(S) Gerry L. Wilcove, William C . Wilson 7. PERFORMING ORGANIZATION NAME

What Good Are Warfare Models?

DTIC Science & Technology

1981-05-01

PROFESSIONAL PAPER 306 / May 1981 WHAT GOOD ARE WARFARE MODELS? Thomas E. Anger DTICS E LECTE ,JUN 2198 1 j CENTER FOR NAVAL ANALYSES 81 6 19 025 V...WHAT GOOD ARE WARFARE MODELS? Thomas E. /Anger J Accession For !ETIS GRA&I DTIC TAB thonnounceldŕ 5 By-C Availability Codes iAva il aand/or Di1st...least flows from a life-or-death incenLive to make good guesses when choosing weapons, forces, or strategies. It is not surprising, however, that

M.H.D. Diagnostics - Gas Temperature and Emittance

DTIC Science & Technology

1960-04-06

AD-A280 700 DTIC $ELECTE M.H.D. DIAGNOSTICS - GAS TEMPERATURE AND EMITTANCE by W. E. HILL REPORT NO. 60GL63 APRIL 6, 1960t i T i n n e iii, ic ie. n ...Accesion For NTIS CRA&I DTIC TAB Una;Olow;ced Justification Distribution y Availability C,.. Avail ard C.A Dist Special GENERAL* ELECTRIC _ l I SCHOWCTADY...from the Instrumen- tation viewpoint. Some of the instrumentation techniques developed $ n the allied field of combustion instrumentation can be expected

Electric Propulsion Study

DTIC Science & Technology

1990-08-01

DTIC FILE COPY AL-TR-89-040 AD: AD-A227 121 Final Report forteprod Electric Propulsion Study 21 Sep 1988 to 30 Nov 1989 DTIC ’ELECTE0OCT 0c 41990u... Electric Propulsion Study (U) 12. PERSONAL AUTHOR(S) Cravens, Dennis J. 13a. TYPE OF REPORT 13b. TIME COVERED 14. DATE OF REPORT (Year, Month, Day) 15. PAGE...identif bv block number) FIELD GROUP SUB-GROUP Inductive theories, electric propulsion, unified field 21 0- theories, Conservatc!±,n Laws, Dynamic

Air Force Office of Scientific Research Technical Report Summaries, Third Quarter 1991

DTIC Science & Technology

1991-09-01

a 0 . C VQ U. -J 0E JC - CO 0 - %. AL W M1 0 𔃾 -’ 0i - 4 CLIOU -ýze4uIn- 0 m *0 3) ()0 OU30 ON-. U WE u IL 01 0L L600 I L M 4U)) 1. -> -0 W.LL . E...ABSTRACT SECURITY CLASSIFICATION 0 UNCLASSIFIED/UNLIMITED C3 SAME AS RPT C DTIC USERS unclassfied 22a. NAME OF RESPONSIBLE INDIVIDUAL 22b. TELEPHONE...OF ’WIS PACE Cl0) 0 0) I- I-r Cl) 0 0 0. OzI :eat I- DD4wO % .0C 0- u. Lii 0-4I 0 IC 0- 0 -- 3, ~~50~ 2 0Oc U 4J- C I Q Li Li . LI~- 4LJ L.) 4. W

48 CFR 227.7103-10 - Contractor identification and marking of technical data to be furnished with restrictive markings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and marking of technical data to be furnished with restrictive markings. 227.7103-10 Section 227.7103... DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Technical Data 227.7103-10 Contractor identification and marking of technical data to be furnished with restrictive markings...

76 FR 2941 - Bureau of Political-Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-18

... services to support the design, manufacture and delivery of the Anik G1 Commercial Communication Satellite... proposed manufacturing license agreement for the manufacture of major defense equipment abroad. The... technical data, and defense services, to Germany for the design, manufacture, market and sale of High-G...

76 FR 76954 - Notice of Amendment No. 004 to the Solicitation for Cooperative Agreement Applications (SCAA...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-09

... Cooperative Agreement Applications (SCAA) Issued on July 7, 2010 AGENCY: Defense Logistics Agency, Department.... SUMMARY: The Defense Logistics Agency (DLA) executes the Department of Defense (DoD) Procurement Technical... applications will only be considered from entities proposing to provide service to an area that will not be...

Technical Concept Document. Central Archive for Reusable Defense Software (CARDS)

DTIC Science & Technology

1994-02-28

FeNbry 1994 INFORMAL TECHNICAL REPORT For The SOFTWARE TECHNOLOGY FOR ADAPTABLE, RELIABLE SYSTEMS (STARS) Technical Concept Document Central Archive for...February 1994 INFORMAL TECHNICAL REPORT For The SOFTWARE TECHNOLOGY FOR ADAPTABLE, RELIABLE SYSTEMS (STARS) Technical Concept Document Central Archive...accordance with the DFARS Special Works Clause Developed by: This document, developed under the Software Technology for Adaptable, Reliable Systems

32 CFR 555.7 - Submission of technical proposals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... research and development laboratories are authorized to submit technical proposals directly to other... 32 National Defense 3 2010-07-01 2010-07-01 true Submission of technical proposals. 555.7 Section... AND NATIONAL CEMETERIES CORPS OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY RESEARCH AND...

Interaction of dacarbazine and imexon, in vitro and in vivo, in human A375 melanoma cells.

PubMed

Samulitis, Betty K; Dorr, Robert T; Chow, H-H Sherry

2011-09-01

We evaluated mechanisms of interaction between the alkyating agent dacarbazine (DTIC) and the pro-oxidant, imexon, in the human A375 melanoma cell line. The effect of DTIC and imexon, alone and in combination, was evaluated for growth inhibition (MTT), radiolabeled drug uptake, cellular thiol content (HPLC), and DNA strand breaks (Comet assay). Pharmacokinetic and antitumor effects were evaluated in mice. Growth inhibition in vitro was additive with the two drugs. There was no effect on drug uptake or on the number of DNA strand breaks. There was a >75% reduction in cellular glutathione and cysteine with imexon but not DTIC. Co-administration of the two drugs in mice caused an increase in the area under the curve of both drugs, but the combination was not effective in reducing human A375 melanoma tumors in vivo. Imexon and dacarbazine show additive effects in vitro but not in vivo in human A375 melanoma cells.

Dacarbazine in melanoma: from a chemotherapeutic drug to an immunomodulating agent.

PubMed

Ugurel, Selma; Paschen, Annette; Becker, Jürgen C

2013-02-01

Chemotherapeutic drugs are clinically used to treat cancer because of their cytotoxic activities against tumor cells. Recently, however, evidence is accumulating-including the report of Hervieu et al. (2012) in the current issue of The Journal of Investigative Dermatology-indicating that at least some of these drugs have broader activities and that they should also be considered immunomodulatory agents. Indeed, Hervieu demonstrates that dacarbazine (DTIC) exerts immunostimulatory effects by inducing local activation of natural killer (NK) and T cells, suggesting that upon treatment with DTIC, the tumor participates in the initiation of an immune response: (i) DTIC treatment elicits the expression of ligands of the immunoreceptor NKG2D on melanoma cells; (ii) engagement of the ligands by NKG2D on NK cells leads to their activation, allowing enhanced tumor-cell killing and the release of IFN-γ; and (iii) IFN-γ in turn upregulates major histocompatibility complex class I expression on tumor cells, which favors their recognition by cytotoxic CD8+ T lymphocytes (CTLs).

An operational system for subject switching between controlled vocabularies: A computational linguistics approach

NASA Technical Reports Server (NTRS)

Silvester, J. P.; Newton, R.; Klingbiel, P. H.

1984-01-01

The NASA Lexical Dictionary (NLD), a system that automatically translates input subject terms to those of NASA, was developed in four phases. Phase One provided Phrase Matching, a context sensitive word-matching process that matches input phrase words with any NASA Thesaurus posting (i.e., index) term or Use reference. Other Use references have been added to enable the matching of synonyms, variant spellings, and some words with the same root. Phase Two provided the capability of translating any individual DTIC term to one or more NASA terms having the same meaning. Phase Three provided NASA terms having equivalent concepts for two or more DTIC terms, i.e., coordinations of DTIC terms. Phase Four was concerned with indexer feedback and maintenance. Although the original NLD construction involved much manual data entry, ways were found to automate nearly all but the intellectual decision-making processes. In addition to finding improved ways to construct a lexical dictionary, applications for the NLD have been found and are being developed.

48 CFR 216.402-2 - Technical performance incentives.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Technical performance incentives. 216.402-2 Section 216.402-2 Federal Acquisition Regulations System DEFENSE ACQUISITION... Contracts 216.402-2 Technical performance incentives. See PGI 216.402-2 for guidance on establishing...

Q-TWiST analysis comparing ipilimumab/dacarbazine vs placebo/dacarbazine for patients with stage III/IV melanoma

PubMed Central

Sherrill, B; Wang, J; Kotapati, S; Chin, K

2013-01-01

Background: Study CA184024 was a multinational, randomised, double-blind, phase 3 study comparing ipilimumab/dacarbazine (DTIC) vs placebo/DTIC in patients with untreated stage III/IV melanoma, which showed that ipilimumab significantly improves survival in patients with metastatic melanoma. The objective of this analysis was to compare the quality-adjusted survival experience among patients in this trial. Methods: Survival time was partitioned into health states: toxicity, time before progression without toxicity, and relapse until death or end of follow-up. Q-TWiST (quality-adjusted time without symptoms of disease or toxicity of treatment) was calculated as the utility-weighted sum of the mean health state durations. Analyses were repeated over extended follow-up periods. Results: Based on a combination of trial-based and external utility scores, the Q-TWiST difference in this trial was 0.50 months (P=0.0326) favoring ipilimumab after 1 year. The Q-TWiST difference was 1.5 months with 2 years of follow-up (P=0.0091), 2.36 months at 3 years (P=0.005) and 3.28 months at 4 years (P=0.0074). Conclusion: During the first year of study, there was little difference between groups in quality-adjusted survival. However, after 2, 3 and 4 years follow-up for patients with extended survival, the benefits of IPI+DTIC vs PLA+DTIC for advanced melanoma continue to accrue. PMID:23787916

48 CFR 227.7103-3 - Early identification of technical data to be furnished to the Government with restrictions on use...

Code of Federal Regulations, 2013 CFR

2013-10-01

... technical data to be furnished to the Government with restrictions on use, reproduction or disclosure. 227..., DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Technical Data 227.7103-3 Early identification of technical data to be furnished to the Government with restrictions...

48 CFR 227.7103-3 - Early identification of technical data to be furnished to the Government with restrictions on use...

Code of Federal Regulations, 2014 CFR

2014-10-01

... technical data to be furnished to the Government with restrictions on use, reproduction or disclosure. 227..., DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Technical Data 227.7103-3 Early identification of technical data to be furnished to the Government with restrictions...

48 CFR 227.7103-3 - Early identification of technical data to be furnished to the Government with restrictions on use...

Code of Federal Regulations, 2012 CFR

2012-10-01

... technical data to be furnished to the Government with restrictions on use, reproduction or disclosure. 227..., DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Technical Data 227.7103-3 Early identification of technical data to be furnished to the Government with restrictions...

Collegiate Cyber Defense Competition Effort

DTIC Science & Technology

2018-03-01

Energy – an electrical utility company. • 2016 : ODIN Security – a small aerospace and defense contracting firm Approved for Public Release...to secure supervisory control and data acquisition (SCADA) networks. Approved for Public Release; Distribution Unlimited 7 During the 2016 NCCDC...COLLEGIATE CYBER DEFENSE COMPETITION EFFORT UNIVERSITY OF TEXAS AT SAN ANTONIO MARCH 2018 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE

76 FR 78958 - Bureau of Political Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-20

..., including technical data, and defense services abroad in the amount of $25,000,000 or more. The transaction... data, and defense services abroad in the amount of $50,000,000 or more. The transaction described in.... Sincerely, David S. Adams, Assistant Secretary, Legislative Affairs. July 25, 2011 (Transmittal Number 11...

48 CFR 252.204-7008 - Export-Controlled Items.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Defense items, defined in the Arms Export Control Act, 22 U.S.C. 2778(j)(4)(A), as defense articles, defense services, and related technical data, and further defined in the ITAR, 22 CFR part 120. (2) Items, defined in the EAR as “commodities, software, and technology,” terms that are also defined in the EAR, 15...

48 CFR 252.204-7008 - Export-Controlled Items.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) Defense items, defined in the Arms Export Control Act, 22 U.S.C. 2778(j)(4)(A), as defense articles, defense services, and related technical data, and further defined in the ITAR, 22 CFR part 120. (2) Items, defined in the EAR as “commodities, software, and technology,” terms that are also defined in the EAR, 15...

48 CFR 252.204-7008 - Export-Controlled Items.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Defense items, defined in the Arms Export Control Act, 22 U.S.C. 2778(j)(4)(A), as defense articles, defense services, and related technical data, and further defined in the ITAR, 22 CFR part 120. (2) Items, defined in the EAR as “commodities, software, and technology,” terms that are also defined in the EAR, 15...

Internal Controls for the Military Sealift Command Portion of the Transportation Business Area of the FY 1994 Defense Business Operations Fund Financial Statements

DTIC Science & Technology

1995-06-28

Secondary Reports Dilution Unit, Audit Planning and Technical Support Directorate, at (703) 604-8937 (DSN 664-8937) or FAX (703) 604-8932. Suggestions...for Future Audits To suggest ideas for or to request future audits , contact the Planning and Coordination Branch, Audit Planning and Technical...Defense OAIG-AUD (ATTN: APTS Audit Suggestions) 400 Army Navy Drive (Room 801) Arlington, Virginia 22202-2884 DoD Hotline To report fraud, waste

Ballistic Missile Defense in the European Theater: Political, Military and Technical Considerations

DTIC Science & Technology

2007-04-15

currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 15 04 2007 2. REPORT TYPE...the European Security Strategy. These strategic documents implicitly and explicitly build a strong case for bolstering missile defense capabilities...states. The NMS advocates the building of a defense in depth by extending defensive capabilities well beyond United States borders, and uses the

Effective Treatment of Advanced Human Melanoma Metastasis in Immunodeficient Mice Using Combination Metronomic Chemotherapy Regimens

PubMed Central

Cruz-Munoz, William; Man, Shan; Kerbel, Robert S.

2009-01-01

Statement of translational relevance Despite significant efforts over the last two decades aimed at improving the efficacy of standard treatment (maximum tolerated dose (MTD) of dacarbazine), there has been no significant increase in the median survival of patients suffering from metastatic melanoma. Given the lack of success achieved, a rethinking of alternative treatment strategies is needed. Using preclinical models of advanced melanoma metastasis, we show that metronomic chemotherapeutic combinations results in improved survival, which is achieved with minimal toxicity. These results compare favorably with minimal effectiveness achieved by MTD dacarbazine therapy (alone or in combination with other chemotherapeutic agents or a VEGFR-blocking antibody), often accompanied by higher toxicity. Successes in preclinical setting of metastatic breast cancer have led to a clinical trial to examine the efficacy of metronomic therapy. A similar extension of the metronomic chemotherapeutic combinations presented here into the clinical setting of melanoma metastasis may be warranted. Purpose The development of effective therapeutic approaches for treatment of metastatic melanoma remains an immense challenge. Present therapies offer minimal benefit. While dacarbazine (DTIC) chemotherapy remains the standard therapy, it mediates only low response rates, usually of short duration, even when combined with other chemotherapeutic agents. Thus, new therapeutic strategies are urgently needed. Experimental design Using a newly developed preclinical model, we evaluated the efficacy of various doublet metronomic combination chemotherapy against established, advanced melanoma metastasis and compared these to the standard maximum tolerated dose (MTD) DTIC (alone or in combination with chemotherapeutic agents or VEGFR-blocking antibody) Results Whereas MTD DTIC therapy did not cause significant improvement in median survival, a doublet combination of low-dose metronomic (LDM) vinblastine (Vbl) and LDM cyclophosphamide (CTX) induced a significant increase in survival with only minimal toxicity. Furthermore, we show that the incorporation of the LDM Vbl/LDM CTX combination with a LDM DTIC regimen also results in a significant increase in survival, but not when combined with MTD DTIC therapy. We also show that a combination of metronomic Vbl therapy and a VEGFR2-blocking antibody (DC101) results in significant control of metastatic disease and that the combination of LDM Vbl/DC101 and LDM DTIC induced a significant improvement in median survival. Conclusions The effective control of advanced metastatic melanoma achieved by these metronomic-based chemotherapeutic approaches warrants clinical consideration of this treatment concept given the recent results of a number of metronomic-based chemotherapy clinical trials. PMID:19622578

77 FR 40937 - Defense Trade Advisory Group; Notice of Open Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-11

... policies, regulations, and technical issues affecting defense trade. The purpose of the meeting will be to... brief statement to the committee in writing. As seating is limited to 125 persons, those wishing to...

48 CFR 237.7300 - Scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... DEFENSE SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING Services of Students at Research and... intermittent services of students at institutions of higher learning for the purpose of providing technical support at Defense research and development laboratories (10 U.S.C. 2360). ...

48 CFR 242.7401 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Procedures. 242.7401 Section 242.7401 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Technical Representation at...

48 CFR 227.7103-9 - Copyright.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Technical Data 227.7103-9 Copyright. (a) Copyright license. (1) The clause at 252.227-7013, Rights in Technical Data... obtained under the clause. When non-standard license rights in technical data will be negotiated, negotiate...

48 CFR 227.7103-6 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Technical Data 227.7103-6 Contract clauses. (a) Use the clause at 252.227-7013, Rights in Technical Data... technical data to the Government. Do not use the clause when the only deliverable items are computer...

Report of the Defense Science Board Task Force on National Aero-Space Plane (NASP) Program

NASA Technical Reports Server (NTRS)

1992-01-01

Six years ago, the Defense Science Board (DSB) initiated a review of the concept, technical basis, program content, and missions of the National Aerospace Plane (NASP) program. The report was completed in Sep. 1988, and the recommendations contributed to strengthening the technical efforts in the NASP program. Since then, substantial technological progress has been made in the technology development phase (Phase 2) of the program. Phase 2 of the program is currently scheduled to end in late Fiscal Year 1993, with a decision whether to proceed to the experimental flight vehicle phase (Phase 3) to be made at that time. This decision will be a very significant one for the Department of Defense (DoD) and the National Aeronautics and Space Administration (NASA). In February of this year, the DSB was chartered to revisit the NASP program to assess the degree to which the many technical challenges of the program have been resolved, or are likely to be resolved by the end of Phase 2.

History of DCAS 1961. Volume V. Origins of the USAF Space Program 1945-1956

DTIC Science & Technology

1961-01-01

AVAILABILITY CODES N! _______________ PHOTOGRAPH TIS SHEET AND RETURN TO DTIC-DDA-2 FORM DOCUMENT PROCESSING SHEE~~DTIC OC 970A OCT 79 AFSC HISTORICAL I...IZ ION OR HIGHER A THO ITY IN T E DI ECT LI COMMAN SIi Prepredundr te poviion ofAirFore Rgultio 21-1 nd ir ori i Sytem ComandSuplemnt N. Itheetoas...information as it appears in the narrative. It is to be hoped that additional information bearing on the formative years of the space program will appear as a

A Review of Vapor Extraction Technology for Contaminated Soil Remediation

DTIC Science & Technology

1993-05-01

NUMBER DATE DTIC ACCESSION 23 MAY 94 NOTICE 1 . REPORT IDENTIFYING INFORMATION I. PU yurmiWin av W A. ORIGINATING anENCY m of ftm...NUMBER W 6 to8 8t. N00123-89-G-0531 2. DISTRIBUTION STATEMENT MTIr" 1 . Aswa AD Nuntw. ŕPPROVED FOR PUPLIC t•ELSASE; 2. ,elumtom ust,. DIST, Ri?-"jTO...8217 ,10" ’J’) ZL DTIC Form 50 PREVIOUS EDITIONS ARE OBSOLETE DEC 91 ,/ / 1 . - ’ < > i•" 1 A REVIEW OF VAPOR EXTRACTION TECHNOLOGY FOR CONTAMINATED SOIL

22 CFR 126.1 - Prohibited exports and sales to certain countries.

Code of Federal Regulations, 2010 CFR

2010-04-01

...-case basis, for supplies of arms and related materials or technical training and assistance intended... Haiti, supplies of arms and related materials for technical training and assistance intended solely for..., defense services or technical data subject to this subchapter may be made to any country referred to in...

22 CFR 125.6 - Certification requirements for exemptions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... LICENSES FOR THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.6 Certification requirements for exemptions. (a) To claim an exemption for the export of technical data under the provisions of.... Certifications consist of clearly marking the package or letter containing the technical data “22 CFR [insert...