Sample records for du prix nobel

  1. Club of Rome

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2006-04-18

    Le Club de Rome s'est fait connaître du grand public par la publication du premier ouvrage "Halte à la croissance" qui a fait l'object d'un débat, il y a 2 ans. Le Prof. Tinbergen a commencé par s'adonner à la physique, il est docteur en physique et très tôt il s'est tourné vers les problèmes sociaux économiques. Il est expert auprès des nombreux gouvernements et organisations internationales et il a vu ses travaux couronnés par le prix Nobel en 1969.

  2. Club of Rome

    ScienceCinema

    None

    2017-12-09

    Le Club de Rome s'est fait connaître du grand public par la publication du premier ouvrage "Halte à la croissance" qui a fait l'object d'un débat, il y a 2 ans. Le Prof. Tinbergen a commencé par s'adonner à la physique, il est docteur en physique et très tôt il s'est tourné vers les problèmes sociaux économiques. Il est expert auprès des nombreux gouvernements et organisations internationales et il a vu ses travaux couronnés par le prix Nobel en 1969.

  3. The Development and Application of Novel Methods for the Solution of EMP Shielding Problems.

    DTIC Science & Technology

    1981-02-01

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  4. Entrevue avec le Dr Charley Zeanah

    PubMed Central

    2013-01-01

    Le Dr Charles Zeanah est titulaire de la chaire de psychiatrie Mary K. Sellars-Polchow, professeur de pédiatrie clinique et vice-président de la pédopsychiatrie au département de psychiatrie et des sciences du comportement de la faculté de médecine de l’Université Tulane, à la Nouvelle-Orléans. Il est également directeur général de l’institut de la santé mentale des nourrissons et des jeunes enfants de Tulane. Il est récipiendaire de nombreux prix, notamment le prix de prévention Irving Phillips (AACAP), la mention élogieuse présidentielle pour sa recherche et son leadership exceptionnels en santé mentale des nourrissons (American Orthopsychiatric Association), le prix d’excellence clinique Sarah Haley Memorial (International Society for Traumatic Stress Studies), le prix de recherche en pédopsychiatrie Blanche F. Ittelson (APA), et le prix Serge Lebovici Award soulignant les contributions internationales à la santé mentale des nourrissons (World Association for Infant Mental Health). Le Dr Zeanah est fellow distingué de l’AACAP, fellow distingué de l’APA et membre du conseil d’administration de Zero to Three. Il est l’éditeur scientifique de Handbook of Infant Mental Health (3e édition) qui est considéré comme étant le manuel de pointe et la référence de base du domaine de la santé mentale des nourrissons.

  5. Nobel laureates in fiction: From La fin du monde to The Big Bang Theory.

    PubMed

    Brodesco, Alberto

    2018-05-01

    The history of the Nobel Prize, since its establishment, interlaces with the history of the public image of science. The aim of this article is to illustrate cinematic scientists, portrayed precisely in their moment of maximum glory. The films and television shows upon which the study is based compose a corpus of 189 media texts. The article identifies three main areas that concern the relation between the Nobel Prize and its audiovisual representations: biopics of real Nobel laureates, the presence of real or fictional Nobel laureates in the film or the show plot, and films and TV series that depict the Nobel ceremony. The article then focuses on four texts that deserve a detailed examination: La fin du monde, The Prize, The Simpsons and The Big Bang Theory. The conclusion compares the representation of the Nobel scientist with general changes in the image of the scientist conveyed by cinema and television.

  6. Helicopter Propulsion Systems

    DTIC Science & Technology

    1981-09-01

    doessais do torborsotour MAKILA nous avons choisi trois easais gui ont pour objet die asiuier qoolguos ones des conditions oxposees prece6demisont et gui...46laLore one lin dv d~bit. Los ossais ao banc consistent A 6rablir cette loi poor 6n fonictionnement aui eol do sorte I cqutiie couvrei lensemble du...laisserons de c6t6 le facteur de ddcroissanco du prix en fonction du rang de s6rie ( loi de Wright) parce que, do par sa g6ndralit6, il n’est pas influenc6

  7. Seminar Andrej Sacharov

    ScienceCinema

    None

    2017-12-09

    A l'occasion de son 63me anniversaire 2 orateurs rendent hommage à A.Sacharov, physicien russe et né à Moscou, pour ses accomplissements scientifiques et son courage. A.Sacharov a dénoncé les dangers de la radioactivité et a tenté de persuader les autorités soviétiques de supprimer une série de test après le developpement de la bombe atomique en 1949 et la bombe à hydrogène en 1953 par un groupe de chercheurs soviétiques. Il a obtenu le prix Nobel en 1975.

  8. Historique en grandes enjambées de la thermodynamique de l'équilibre

    NASA Astrophysics Data System (ADS)

    Hertz, J.

    2004-12-01

    La Thermodynamique, une science totalement nouvelle au XIXème siècle, a germé en France en contrepoint des idées du siècle des Lumières, dans le milieu particulier des anciens élèves de l’Ecole Polytechnique, officiers supérieurs formés pour l’armée républicaine ou napoléonienne, mais qui ne trouvaient plus leur place dans l’armée de la Restauration. Ils se convertissaient en ingénieurs civils des métiers industriels en pleine expansion, comme le développement de la machine à vapeur ou des chemins de fer. La plupart d’entre eux, plutôt libre-penseurs, adhéraient aux idées scientistes du « positivisme », véhiculées dans les Loges de la Franc-Maçonnerie du Grand Orient de France et plus particulièrement dans les cercles Saint-Simoniens, premiers adeptes du socialisme industriel. C’est ainsi que naquit en 1824, dans le cerveau subtil mais brouillon de Sadi Carnot toute la vision illuminée de cette science nouvelle, incompréhensible pour ses contemporains. Elle ressuscita en 1834 sous la plume d’un Emile Clapeyron qui avait pris conscience de l’immensité de l’œuvre de Sadi Carnot. Mais le rappel de Clapeyron demeura également sans écho pendant dix années. Le réveil de la Thermodynamique se fera désormais hors de France par des hommes de grande pratique religieuse et généralement protestants. C’est ainsi que William Thomson en Ecosse et Rudolph Clausius, venu de Prusse, achevèrent l’œuvre de leurs deux prédécesseurs et que la Thermodynamique mécano-thermique fut définitivement établie en 1864. La thermodynamique chimique peut être attribuée à un seul génie mathématicien, Josiah Willard Gibbs qui travaillait tout seul au Yale College de New-Haven, dans le Connecticut, et rédigea sa nouvelle théorie entre 1875 et 1878. Enfin l’interprétation statistique du second principe sera l’œuvre en 1877 d’un Autrichien, Ludwig Boltzmann, homme génial mais fragile qui eut le temps d’insuffler ses idées sur la quantification de l’énergie à l’Allemand Max Planck, premier prix Nobel de la nouvelle discipline.

  9. Tunneling in Superconductors

    NASA Astrophysics Data System (ADS)

    Giaever, Ivar

    2002-03-01

    It has been said that Thomas Edison's greatest invention was that of the "Research Laboratory" as a social institution. My greatest discovery was when I learned at 29 years of age that it was possible to work in such an institution and get paid for doing research. I had become interested in physics, gotten a job at General Electric Research Laboratory and found a great mentor in John C. Fischer, who besides instructing me in physics told me that sooner or later we all would become historians of science. I guess for me that time is now, because I have been asked to tell you about my second greatest discovery: Tunneling in superconductors. My great fortune was to be at the right place at the right time, where I had access to outstanding and helpful (not necessary an oxymoron) physicists. Hopefully I will be able to convey to you some of the fun and excitement of that area in this recollection. If you become real interested you may find a written version in my Nobel Prize talk: "Electron Tunneling and Superconductivity" Les Prix Nobel en 1973 or Science 183, 1253-1258 1974 or Reviews of Modern Physics 46 (2), 245-250 1974

  10. Polio and Nobel prizes: looking back 50 years.

    PubMed

    Norrby, Erling; Prusiner, Stanley B

    2007-05-01

    In 1954, John Enders, Thomas Weller, and Frederick Robbins were awarded the Nobel Prize in Physiology or Medicine "for their discovery of the ability of poliomyelitis viruses to grow in cultures of various types of tissue."5370 This discovery provided for the first time opportunities to produce both inactivated and live polio vaccines. By searching previously sealed Nobel Committee archives, we were able to review the deliberations that led to the award. It appears that Sven Gard, who was Professor of Virus Research at the Karolinska Institute and an adjunct member of the Nobel Committee at the time, played a major role in the events leading to the awarding of the Prize. It appears that Gard persuaded the College of Teachers at the Institute to decide not to follow the recommendation by their Nobel Committee to give the Prize to Vincent du Vigneaud. Another peculiar feature of the 1954 Prize is that Weller and Robbins were included based on only two nominations submitted for the first time that year. In his speech at the Nobel Prize ceremony, Gard mentioned the importance of the discovery for the future production of vaccines, but emphasized the implications of this work for growing many different, medically important viruses. We can only speculate on why later nominations highlighting the contributions of scientists such as Jonas Salk, Hilary Koprowski, and Albert Sabin in the development of poliovirus vaccines have not been recognized by a Nobel Prize.

  11. Andrei Sakharov

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2006-07-07

    Ce discours donné par Mons.Jonauch qui est né en Tchécoslovaquie et a fait ses études à Leningrad, Moscou et Prague, est organisé par le comité Youri Orlov. Le conférencier parle de Andrei Sakharov, ce physicien et homme soviétique qui fit ses études à Moscou, effectua des recherches sur les armes thermonucléaires et entra à l'Académie des Sciences d'URSS en 1953. Il participa à la mise au point de la bombe à hydrogène, mais s'opposa quelques années plus tard à la poursuite des expériences nucléaires. Il créa en 1970 le comité pour la défense des droits de l'homme ce que luimore » valut le prix Nobel de la paix en 1975.« less

  12. Rappels vaccinaux hors programme élargi de vaccination dans deux écoles de l’éducation de base de Yaoundé, Cameroun

    PubMed Central

    Vougmo Meguejio Njua, Clémence; Nguefack, Félicitée; Chelo, David; Tejiokem, Mathurin; Kago, Innocent; Kobela, Marie

    2011-01-01

    Introduction L'absence des rappels vaccinaux est problématique dans les pays en développement où certaines maladies évitables par la vaccination font encore des victimes chez les enfants en raison d'une immunisation incomplète. L'identification des raisons de non rappel vaccinaux permettrait de proposer des solutions adaptées afin d'améliorer le statut vaccinal des enfants au-delà de 12 mois. Méthodes Cette étude descriptive transversale avait pour objectif d’évaluer le taux de rappels vaccinaux des enfants au-delà de la cible du programme élargi de vaccination (PEV). Elle s'est déroulée de Septembre à Novembre 2009 dans deux écoles d’éducation de base de Yaoundé. L’échantillonnage était consécutif et limité aux élèves âgés de deux à sept ans possédant des carnets de vaccination. Par souci d'uniformité, nous n'avons pas analysé les rappels des vaccins contre l'hépatite B et l'haemophilus introduits tardivement au Cameroun. Résultats L’étude a porté sur 310 élèves. La tranche d’âge de 2 à 4 ans représentait 69%. Seul 223 enfants (71,9%) étaient correctement vaccinés. Quant aux rappels vaccinaux diphtérie-tétanos-coqueluche et poliomyélite, les couvertures étaient insignifiantes (2,7% et 0% respectivement pour la première et la deuxième dose). Les raisons évoquées étaient l'absence de sensibilisation des parents (50%), le prix élevé des vaccins (48,69%) et la désinformation (1,31%). Conclusion Le recyclage du personnel de santé sur la vaccination est une nécessité. Les parents doivent être informés sur le déroulement, les prix et les lieux des rappels vaccinaux. La réduction des prix de vaccins faciliterait l'accès à une large tranche de la population. PMID:22187602

  13. 75 FR 20920 - Safety Zone; Lake Havasu Grand Prix, Lake Havasu, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ...-AA00 Safety Zone; Lake Havasu Grand Prix, Lake Havasu, AZ AGENCY: Coast Guard, DHS. ACTION: Temporary... of Lake Havasu on the Colorado River in Lake Havasu City, Arizona for the Lake Havasu Grand Prix... established in support of the Lake Havasu Grand Prix, a marine event that includes participating vessels...

  14. Andrei Sakharov

    ScienceCinema

    None

    2017-12-09

    Ce discours donné par Mons.Jonauch qui est né en Tchécoslovaquie et a fait ses études à Leningrad, Moscou et Prague, est organisé par le comité Youri Orlov. Le conférencier parle de Andrei Sakharov, ce physicien et homme soviétique qui fit ses études à Moscou, effectua des recherches sur les armes thermonucléaires et entra à l'Académie des Sciences d'URSS en 1953. Il participa à la mise au point de la bombe à hydrogène, mais s'opposa quelques années plus tard à la poursuite des expériences nucléaires. Il créa en 1970 le comité pour la défense des droits de l'homme ce que lui valut le prix Nobel de la paix en 1975.

  15. 78 FR 22814 - Special Local Regulations; Miami Super Boat Grand Prix, Atlantic Ocean; Miami Beach, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ...-AA08 Special Local Regulations; Miami Super Boat Grand Prix, Atlantic Ocean; Miami Beach, FL AGENCY... Super Boat Grand Prix. The Miami Super Boat Grand Prix will consist of a series of high-speed boat races... of the participants, spectators, and the general public during the high-speed boat races. The special...

  16. 78 FR 33969 - Special Local Regulations; Daytona Beach Grand Prix of the Sea, Atlantic Ocean; Daytona Beach, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... 1625-AA08 Special Local Regulations; Daytona Beach Grand Prix of the Sea, Atlantic Ocean; Daytona Beach... Daytona Beach Grand Prix of the Sea, a series of high-speed boat races. The event is scheduled to take... United States during the Daytona Beach Grand Prix of the Sea. C. Discussion of the Final Rule On Friday...

  17. 76 FR 26931 - Safety Zone; Second Annual Space Coast Super Boat Grand Prix, Atlantic Ocean, Cocoa Beach, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ...-AA00 Safety Zone; Second Annual Space Coast Super Boat Grand Prix, Atlantic Ocean, Cocoa Beach, FL... Annual Space Coast Super Boat Grand Prix. The Second Annual Space Coast Super Boat Grand Prix will consist of a series of high- speed boat races. The event is scheduled to take place on Saturday, May 21...

  18. Vincent du Vigneaud: following the sulfur trail to the discovery of the hormones of the posterior pituitary gland at Cornell Medical College.

    PubMed

    Ottenhausen, Malte; Bodhinayake, Imithri; Banu, Matei A; Stieg, Philip E; Schwartz, Theodore H

    2016-05-01

    In 1955, Vincent du Vigneaud (1901-1978), the chairman of the Department of Biochemistry at Cornell University Medical College, was awarded the Nobel Prize for Chemistry for his research on insulin and for the first synthesis of the posterior pituitary hormones-oxytocin and vasopressin. His tremendous contribution to organic chemistry, which began as an interest in sulfur-containing compounds, paved the way for a better understanding of the pituitary gland and for the development of diagnostic and therapeutic tools for diseases of the pituitary. His seminal research continues to impact neurologists, endocrinologists, and neurosurgeons, and enables them to treat patients who had no alternatives prior to du Vigneaud's breakthroughs in peptide structure and synthesis. The ability of neurosurgeons to aggressively operate on parasellar pathology was directly impacted and related to the ability to replace these hormones after surgery. The authors review the life and career of Vincent du Vigneaud, his groundbreaking discoveries, and his legacy of the understanding and treatment of the pituitary gland in health and disease.

  19. Commerce de detail de l'essence automobile: Modelisation de l'impact a court terme des facteurs endogenes et exogenes sur les ventes d'essence dans les stations-service a Montreal

    NASA Astrophysics Data System (ADS)

    Nguimbus, Raphael

    La determination de l'impact des facteurs sous controle et hors controle qui influencent les volumes de vente des magasins de detail qui vendent des produits homogenes et fortement substituables constitue le coeur de cette these. Il s'agit d'estimer un ensemble de coefficients stables et asymtotiquement efficaces non correles avec les effets specifiques aleatoires des sites d'essence dans le marche de Montreal (Quebec, Canada) durant is periode 1993--1997. Le modele econometrique qui est ainsi specifie et teste, isole un ensemble de quatre variables dont le prix de detail affiche dans un site d'essence ordinaire, la capacite de service du site pendant les heures de pointe, les heures de service et le nombre de sites concurrents au voisinage du site dans un rayon de deux kilometres. Ces quatre facteurs influencent les ventes d'essence dans les stations-service. Les donnees en panel avec les methodes d'estimation robustes (estimateur a distance minimale) sont utilisees pour estimer les parametres du modele de vente. Nous partons avec l'hypothese generale selon laquelle il se developpe une force d'attraction qui attire les clients automobilistes dans chaque site, et qui lui permet de realiser les ventes. Cette capacite d'attraction varie d'un site a un autre et cela est du a la combinaison de l'effort marketing et de l'environnement concurrentiel autour du site. Les notions de voisinage et de concurrence spatiale expliquent les comportements des decideurs qui gerent les sites. Le but de cette these est de developper un outil d'aide a la decision (modele analytique) pour permettre aux gestionnaires des chaines de stations-service d'affecter efficacement les ressources commerciales dans ies points de vente.

  20. Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster.

    PubMed

    Holzer, Sandro; Yan, Jiangyu; Kilkenny, Mairi L; Bell, Stephen D; Pellegrini, Luca

    2017-11-23

    DNA replication depends on primase, the specialised polymerase responsible for synthesis of the RNA primers that are elongated by the replicative DNA polymerases. In eukaryotic and archaeal replication, primase is a heterodimer of two subunits, PriS and PriL. Recently, a third primase subunit named PriX was identified in the archaeon Sulfolobus solfataricus. PriX is essential for primer synthesis and is structurally related to the Fe-S cluster domain of eukaryotic PriL. Here we show that PriX contains a nucleotide-binding site required for primer synthesis, and demonstrate equivalence of nucleotide-binding residues in PriX with eukaryotic PriL residues that are known to be important for primer synthesis. A primase chimera, where PriX is fused to a truncated version of PriL lacking the Fe-S cluster domain retains wild-type levels of primer synthesis. Our evidence shows that PriX has replaced PriL as the subunit that endows primase with the unique ability to initiate nucleic acid synthesis. Importantly, our findings reveal that the Fe-S cluster is not required for primer synthesis.

  1. 75 FR 21194 - Special Local Regulation; Harrison Township Grand Prix, Lake St. Clair; Harrison Township, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ...-AA08 Special Local Regulation; Harrison Township Grand Prix, Lake St. Clair; Harrison Township, MI... establishing a temporary special local regulation in the Captain of the Port Detroit Zone on Lake St. Clair... Lake St. Clair during the Harrison Township Grand Prix. This special local regulation is necessary to...

  2. 75 FR 22333 - Safety Zone; Michigan City Super Boat Grand Prix, Lake Michigan, Michigan City, IN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ...-AA00 Safety Zone; Michigan City Super Boat Grand Prix, Lake Michigan, Michigan City, IN AGENCY: Coast... temporary safety zone on Lake Michigan near Michigan City, Indiana. This zone is intended to restrict... ensure the safety of vessels from the hazards associated with the Michigan City Super Boat Grand Prix...

  3. 75 FR 34932 - Safety Zone; Michigan City Super Boat Grand Prix, Lake Michigan, Michigan City, IN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ...-AA00 Safety Zone; Michigan City Super Boat Grand Prix, Lake Michigan, Michigan City, IN AGENCY: Coast... zone on Lake Michigan near Michigan City, Indiana. This zone is intended to restrict vessels from a... of proposed rulemaking (NPRM) entitled Safety Zone; Michigan City Super Boat Grand Prix, Lake...

  4. 77 FR 15600 - Special Local Regulation; Emerald Coast Super Boat Grand Prix; Saint Andrew Bay; Panama City, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ...-AA08 Special Local Regulation; Emerald Coast Super Boat Grand Prix; Saint Andrew Bay; Panama City, FL... navigable waters during the Emerald Coast Super Boat Grand Prix high speed boat races. Entry into... Marine Event Permit on January 31, 2011 from Super Boat International, Inc. to conduct a high speed boat...

  5. 77 FR 15006 - Special Local Regulations; Third Annual Space Coast Super Boat Grand Prix, Atlantic Ocean, Cocoa...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ...-AA08 Special Local Regulations; Third Annual Space Coast Super Boat Grand Prix, Atlantic Ocean, Cocoa..., Florida during the Third Annual Space Coast Super Boat Grand Prix, a series of high-speed boat races. The event is scheduled to take place on Sunday, May 20, 2012. Approximately 30 high-speed race boats are...

  6. 78 FR 28164 - Special Local Regulation; Aguada Offshore Grand Prix, Bahia de Aguadilla; Aguada, PR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... Aguada Offshore Grand Prix, a high speed boat race. The event is scheduled to take place on Sunday, August 4, 2013. Approximately 30 high-speed power boats will be participating in the races. It is... Series, Inc. is sponsoring the Aguada Offshore Grand Prix, a series of high-speed boat races. The races...

  7. Suivi thérapeutique pharmacologique de trois médicaments antiépileptiques: retour sur vingt années d’expérience

    PubMed Central

    Serragui, Samira; Zalagh, Fatima; Tanani, Driss Soussi; Ouammi, Lahcen; Moussa, Latifa Ait; Badrane, Narjis; Bencheikh, Rachida Soulaymani

    2016-01-01

    Introduction Le suivi thérapeutique pharmacologique (STP) des médicaments antiépileptiques (MAE) est un outil très utilisé dans la gestion de l'épilepsie. Au Maroc, ce dosage est réalisé au Centre Anti Poison et de Pharmacovigilance du Maroc (CAPM) depuis Avril 1995. Méthodes Il s'agit d'une étude rétrospective s'étalant sur 20 ans. Elle concerne le STP du Phénobarbital (PB), de la Carbamazépine (CBZ) et de l'Acide Valproique (AVP). Résultats Le STP des 3 MAE représentaient 58,85% de l'ensemble des demandes de STP reçue par le CAPM. Le dosage du PB était classé en première position suivi par celui de la CBZ et enfin par l'AVP. La faible demande de STP au Maroc pouvait être expliquée par le faible nombre de neurologues auquel s'ajoutaient des facteurs sociaux. Grâce à son prix très accessible par les patients, le PB est le MAE le plus prescrit dans notre pays expliquant ainsi la demande élevée de son dosage. Quant aux motifs de STP des 3 MAE, ils étaient essentiellement liés à l'âge, à l'apparition d'effets indésirables, à l'association de MAE ou dans le cas de vérification de l'observance des malades. Conclusion Des efforts sont à fournir pour promouvoir l'intérêt du STP des MAE dans la prise en charge de l'épilepsie au Maroc. PMID:28154702

  8. Design and Test Results of AMIGO: A Novel Remote Ground Sensor System

    DTIC Science & Technology

    2007-01-01

    prix ou dans l’IR à prix élevé); le corps principal équipé de capteurs et de composants électroniques de base à faible prix ; et une plate-forme...reine, représentée par le ministre de la Défense nationale, 2007 DRDC Valcartier TR 2005-272 i Abstract The objectives of the project...Observation) a pour but d’étudier les technologies relatives aux systèmes de détecteurs autonomes au sol (DAS) et de mettre au point, puis de

  9. Review of National Work Programme on the Long Term Effects of Sustained High G on the Cervical Spine (Analyse du programme de travail national : les effets long terme sur la colonne cervicale d’un nombre de G lev et prolong )

    DTIC Science & Technology

    2008-12-01

    Prof. Karin Harms-Ringdahl, PhD, RPT Karolinska Institutet Department of Neurobiology, Care Sciences, and Society Division of Physiotherapy 23100...Äng Karolinska Institutet Department of Neurobiology, Care Sciences, and Society Division of Physiotherapy Alfred Nobels Allé 23100 SE-14183...report is in preparation. The RAF has an ongoing project (from August 2006 to September 2007) determining the need for physiotherapy for aircrew on the

  10. Les brulures electriques chez les voleurs de cuivre

    PubMed Central

    Belmir, R.; Fejjal, N.; Achbouk, H.; El Mazouz, S.; Gharib, N.; Abassi, A.; Belmahi, A.

    2011-01-01

    Summary Les vols de biens fabriqués avec le cuivre semblent en hausse depuis un certain temps du fait de son prix élevé de revente, ce qui est à l’origine d’une augmentation du nombre d’accidents électriques par haut voltage (AEHV) qui sont graves du fait des brûlures profondes qu’elles provoquent le long des axes vasculo-nerveux. Les Auteurs rapportent une série de neuf cas d’AEHV traités au service de chirurgie plastique et de brûlés de l’Hôpital Ibn Sina de Rabat, Maroc, à travers laquelle ils étudient les caractéristiques épidémiologiques, cliniques et thérapeutiques. La population intéressée était jeune et active. Les brûlures étaient secondaires à un contact avec des câbles à haute tension lors de tentatives de vol par arrachement de conducteurs en cuivre dans les transformateurs dans 67% des cas, et lors de tentatives de coupure de caténaires alimentant les trains électriques sur le réseau ferroviaire dans 33% des cas. Le traitement des lésions électrothermiques a nécessité des interventions itératives avec amputation et désarticulation des segments de membres nécrosés dans 66% des cas, dont les suites étaient marquées par des séquelles fonctionnelles invalidantes. La prévention de ce type d’AEHV reste fondamentale. PMID:22262961

  11. 33 CFR 100.912 - Detroit Bell Isle Grand Prix, Detroit, MI.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Detroit Bell Isle Grand Prix, Detroit, MI. 100.912 Section 100.912 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.912 Detroit Bell Isle Grand...

  12. 78 FR 7331 - SLR; Fajardo Offshore Grand Prix; Rada Fajardo; Fajardo, PR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ... waters of Rada Fajardo in Fajardo, Puerto Rico during the Fajardo Offshore Grand Prix, a high speed boat race. The event is scheduled to take place on Sunday, March 17, 2013. Approximately 30 high-speed power... vessels participating in the high-speed boat races, are prohibited from entering, transiting through...

  13. Caracterisation thermique de modules de refroidissement pour la photovoltaique concentree

    NASA Astrophysics Data System (ADS)

    Collin, Louis-Michel

    Pour rentabiliser la technologie des cellules solaires, une reduction du cout d'exploitation et de fabrication est necessaire. L'utilisation de materiaux photovoltaiques a un impact appreciable sur le prix final par quantite d'energie produite. Une technologie en developpement consiste a concentrer la lumiere sur les cellules solaires afin de reduire cette quantite de materiaux. Or, concentrer la lumiere augmente la temperature de la cellule et diminue ainsi son efficacite. Il faut donc assurer a la cellule un refroidissement efficace. La charge thermique a evacuer de la cellule passe au travers du recepteur, soit la composante soutenant physiquement la cellule. Le recepteur transmet le flux thermique de la cellule a un systeme de refroidissement. L'ensemble recepteur-systeme de refroidissement se nomme module de refroidissement. Habituellement, la surface du recepteur est plus grande que celle de la cellule. La chaleur se propage donc lateralement dans le recepteur au fur et a mesure qu'elle traverse le recepteur. Une telle propagation de la chaleur fournit une plus grande surface effective, reduisant la resistance thermique apparente des interfaces thermiques et du systeme de refroidissement en aval vers le module de refroidissement. Actuellement, aucune installation ni methode ne semble exister afin de caracteriser les performances thermiques des recepteurs. Ce projet traite d'une nouvelle technique de caracterisation pour definir la diffusion thermique du recepteur a l'interieur d'un module de refroidissement. Des indices de performance sont issus de resistances thermiques mesurees experimentalement sur les modules. Une plateforme de caracterisation est realisee afin de mesurer experimentalement les criteres de performance. Cette plateforme injecte un flux thermique controle sur une zone localisee de la surface superieure du recepteur. L'injection de chaleur remplace le flux thermique normalement fourni par la cellule. Un systeme de refroidissement est installe a la surface opposee du recepteur pour evacuer la chaleur injectee. Les resultats mettent egalement en evidence l'importance des interfaces thermiques et les avantages de diffuser la chaleur dans les couches metalliques avant de la conduire au travers des couches dielectriques du recepteur. Des recepteurs de multiples compositions ont ete caracterises, demontrant que les outils developpes peuvent definir la capacite de diffusion thermique. La repetabilite de la plateforme est evaluee par l'analyse de l'etendue des mesures repetees sur des echantillons selectionnes. La plateforme demontre une precision et reproductibilite de +/- 0.14 ° C/W. Ce travail fournit des outils pour la conception des recepteurs en proposant une mesure qui permet de comparer et d'evaluer l'impact thermique de ces recepteurs integres a uri module de refroidissement. Mots-cles : cellule solaire, photovoltaique, transfert de chaleur, concentration, resistances thermiques, plateforme de caracterisation, refroidissement

  14. 76 FR 37875 - Temporary Closure of I-395 Just South of Conway Street in the City of Baltimore to Vehicular...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-28

    ... the Construction and Operation of the Baltimore Grand Prix AGENCIES: Federal Highway Administration... construction and operation of the Baltimore Grand Prix (BGP), which will use the streets of downtown Baltimore.... John C. Nicholas, Truck Size and Weight Team, Office of Operations, (202) 366-2317, Mr. Bill Winne...

  15. 77 FR 52784 - 2012 Temporary Closure of I-395 Just South of Conway Street in the City of Baltimore to Vehicular...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ... Accommodate the Construction and Operation of the Baltimore Grand Prix AGENCY: Federal Highway Administration.... The closure is requested to accommodate the construction and operation of the Baltimore Grand Prix... most arriving by private vehicle. The construction and operation of the race course will create safety...

  16. 78 FR 28011 - 2013 Temporary Closure of I-395 Just South of Conway Street in the City of Baltimore to Vehicular...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... Accommodate the Construction and Operation of the Baltimore Grand Prix AGENCIES: Federal Highway... accommodate the construction and operation of the Baltimore Grand Prix (BGP), which will use the streets of... Freight Management and Operations, Office of Operations, (202) 366-2976, Mr. Bill Winne, Office of the...

  17. 75 FR 39445 - Special Local Regulation; Harrison Township Grand Prix, Lake St. Clair, Harrison Township, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ...-AA08 Special Local Regulation; Harrison Township Grand Prix, Lake St. Clair, Harrison Township, MI... temporary special local regulation in the Captain of the Port Detroit Zone on Lake St. Clair, Harrison Township, Michigan. This special local regulation is intended to restrict vessels from portions of Lake St...

  18. Alt-Energy Grand Prix Inspires an "I Can" Attitude

    ERIC Educational Resources Information Center

    Tessmer, Al; Trzeciak, Mark

    2010-01-01

    This article describes how a team comprised largely of high school students builds and races an E85-fueled car and takes first place at the Bowling Green (Ohio) State University (BGSU) Grand Prix. Free and open to the public, the event features student drivers and crews, racing go-karts powered by renewable, ethanol-based E85 fuel. The track is a…

  19. 77 FR 47522 - Special Local Regulation; Port Huron Offshore Gran Prix, St. Clair River; Port Huron, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ...-AA08 Special Local Regulation; Port Huron Offshore Gran Prix, St. Clair River; Port Huron, MI AGENCY... regulation on the St. Clair River, Port Huron, Michigan. This action is necessary and intended to ensure... movement of, vessels in a portion of the St. Clair River. During the enforcement period, no person or...

  20. 78 FR 25574 - Special Local Regulations; Third Annual Space Coast Super Boat Grand Prix, Atlantic Ocean; Cocoa...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-02

    ... the Space Coast Super Boat Grand Prix, a series of high-speed boat races. The event is scheduled to take place on Saturday and Sunday, May 18-19, 2013, and approximately 30 high-speed race boats are... inherent dangers involved with a high-speed race and the number of vessels involved, it is in the best...

  1. Heike Kamerlingh Onnes: Master of Experimental Technique and Quantitative Research

    NASA Astrophysics Data System (ADS)

    Reif-Acherman, Simón

    Heike Kamerlingh Onnes (1853-1926), born a century and a half ago, was a major protagonist in the so-called Second Golden Age of Dutch Science. He devoted his career to the emerging field of low-temperature physics. His particular concern was to test the theories of his older compatriot Johannes Diderik van der Waals (1837-1923) by creating a style of research that was characterized by meticulous planning, precise measurement, and constant improvement of techniques and instruments. He made numerous contributions to low-temperature physics, but I focus on his liquefaction of helium, for which he received the Nobel Prize in Physics for 1913, and on his discovery of superconductivity. He became known internationally as le gentleman du zéro absolu.

  2. La tuberculose cutanée: observation de six cas confirmés au CHU Souro SANOU (CHUSS) de Bobo-Dioulasso (Burkina Faso)

    PubMed Central

    Andonaba, Jean Baptiste; Barro-Traoré, Fatou; Yaméogo, Téné; Diallo, Boukary; Korsaga-Somé, Nina; Traoré, Adama

    2013-01-01

    La localisation cutanée de la maladie tuberculeuse demeure une forme rare et représente seulement 2,1% des localisations. L'objet de cette étude est de rapporter le profil épidémiologique, anatomoclinique et évolutif des cas de tuberculose ganglio-cutanée diagnostiqués dans un CHU au Burkina Faso. La fréquence de la tuberculose cutanée est très faible au CHUSS. Six cas ont été diagnostiqués entre 2004 et 2010, soit une fréquence de un cas par an. La durée d’évolution des cas allait de deux jusqu’à dix ans avant leur diagnostic. Les lésions observées étaient: trois scrofulodermes, trois gommes, une tuberculose testiculaire associée à un mal de Pott, un cas de polyadénopathies et des cicatrices atropho-rétractiles dans la plupart des cas. Sur le plan anatomopathologique, des granulomes tuberculoïdes ont été mis en évidence dans tous les cas avec une forte réaction tuberculinique à l'IDR. Sous antituberculeux pendant six mois, l’évolution a été bonne dans tous les cas mais au prix de séquelles cutanées cicatricielles inesthétiques. Son ampleur reste peut-être encore méconnue. Le renforcement du plateau technique du CHU et une bonne collaboration interdisciplinaire contribuerait à un meilleur diagnostic et prise en charge de cette affection. PMID:24648863

  3. Scientific Productivity and Idea Acceptance in Nobel Laureates

    ERIC Educational Resources Information Center

    Charyton, Christine; DeDios, Samantha Lynn; Nygren, Thomas Eugene

    2015-01-01

    We investigated how new ideas become accepted for Nobel laureates in science. Archival data were collected for 204 Nobel laureates from 1980 to 2009 in physics, chemistry, and medicine or physiology. Acceptance was evaluated for Nobel laureates by Prize area and three key publications in the Nobel laureates' publishing careers: (a) first…

  4. Smoot Group Cosmology

    Science.gov Websites

    __________________________________________________ Nobel Prize funds will be donated to Fellowships: Berkeley Nobel laureates donate prize money to charity SF Gate New Nobel Laureate Donates Prize Money to Local Charity The Daily Californian Nobel laureate

  5. Television Experience Patterns in Children and Juveniles; Illustrated by the Prize-Winning Programmes of the Prix Jeunesse 1964. Research Report. Publications of the International Central Institute for Youth and Educational Television. No.1.

    ERIC Educational Resources Information Center

    Keilhacker, Margarete; Vogg, Gunther

    A study to test the appeal, reception, and response quality in the case of programs screened at the 1st. Prix Jeunesse contest in Munich by the observation of children and juveniles (age-grouped 6 to 12, 12 to 15, and 15 and over) is described in this paper. Specific questions considered are: 1. What conditions govern appeal? 2. Are age and sex…

  6. Nominee and nominator, but never Nobel Laureate: Vincenz Czerny and the Nobel Prize.

    PubMed

    Hansson, Nils; Tuffs, Annette

    2016-12-01

    The Heidelberg surgeon Vincenz Czerny (1842-1916) is remembered as pioneer of innovative operations as well as entrepreneur of interdisciplinary cancer therapy. The purpose of this paper is to describe his role during the early history of the Nobel Prize in physiology or medicine. Based on documents from the Nobel Archive, this paper investigates how Czerny contributed, both as nominee and nominator, in shaping the early years of Nobel Prize history. Vincenz Czerny was nominated at least three times for the Nobel Prize, but he was never selected. Czerny's own nomination letters pinpoint important trends in medicine around the turn of the century. At least seven of the candidates he put forward, became Nobel Laureates. Czerny-like many other internationally renowned surgeons during the first decades of the twentieth century-missed out on the Nobel Prize, partly because it is not a lifetime award and his work would have to have been more recent. However, with his nominations, Czerny helped to shape the Nobel Prize to become the most important scientific award worldwide.

  7. When a misperception favors a tragedy: Carlos Chagas and the Nobel Prize of 1921.

    PubMed

    Bestetti, Reinaldo B; Couto, Lucélio B; Cardinalli-Neto, Augusto

    2013-11-20

    Carlos Chagas, the discoverer of Chagas' disease was nominated to the Nobel Prize in 1921, but none did win the prize in that year. As a leader of a young scientist team, he discovered all aspects of the new disease from 1909 to 1920. It is still obscure why he did not win the Nobel Prize in 1921. Chagas was discarded by Gunnar Hedrèn on April 16, 1921. Hedrèn should have made a written report about the details of his evaluation to the Nobel Committee. However, such a document has not been found in the Nobel Committee Archives. No evidence of detractions made by Brazilian scientists on Chagas was found. Since Chagas nomination was consistent with the Nobel Committee requirements, as seen in the presentation letter by until now unknown Cypriano de Freitas, it become clear that Chagas did not win the Nobel Prize exclusively because the Nobel Committee did not perceive the importance of his discovery. Thus, it would be fair a posthumous Nobel Prize of 1921 to Carlos Chagas. A diploma of the Nobel Prize, as precedent with Dogmack in 1947, would recognize the merit of the scientist who made the most complete medical discovery of all times. © 2013 Elsevier Ireland Ltd. All rights reserved.

  8. The Nobel Legacy: A Journey through Chemistry Inspired by the Achievements of Nobel Laureates.

    PubMed

    Novara, Francesca Rita; Ross, Haymo

    2018-03-15

    The Prize is right! Chemistry-A European Journal will start an exciting journey exploring the significance of Nobel Prize awards in Chemistry in the corresponding contemporary chemistry fields. In this new journal feature called "The Nobel Legacy", a recurring series of invited Review-type articles each one connected to a particular Nobel Prize in Chemistry will be published. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Old Fire/Grand Prix Fire, California

    NASA Image and Video Library

    2003-11-19

    On November 18, 2003, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite acquired this image of the Old Fire/Grand Prix fire east of Los Angeles. The image is being processed by NASA's Wildfire Response Team and will be sent to the United States Department of Agriculture's Forest Service Remote Sensing Applications Center (RSAC) which provides interpretation services to Burned Area Emergency Response (BAER) teams to assist in mapping the severity of the burned areas. The image combines data from the visible and infrared wavelength regions to highlight the burned areas. http://photojournal.jpl.nasa.gov/catalog/PIA04879

  10. [Commentary on the Nobel Prize that has been granted in Medicine-Physiology, Chemistry and Physics to noteable investigators].

    PubMed

    Zárate, Arturo; Apolinar, Leticia Manuel; Saucedo, Renata; Basurto, Lourdes

    2015-01-01

    The Nobel Prize was established by Alfred Nobel in 1901 to award people who have made outstanding achievements in physics, chemistry and medicine. So far, from 852 laureates, 45 have been female. Marie Curie was the first woman to receive the Nobel Prize in 1903 for physics and eight years later also for chemistry It is remarkable that her daughter Irene and her husband also received the Nobel Prize for chemistry in 1935. Other two married couples, Cori and Moser, have also been awarded the Nobel Prize. The present commentary attempts to show the female participation in the progress of scientific activities.

  11. The Nobel Peace Prizes as Teaching Tools. Educational Resources.

    ERIC Educational Resources Information Center

    Abrams, Irwin

    1994-01-01

    Asserts that the Nobel Peace Prize provides a gateway for teaching the critical issue of peace in history courses. Presents an overview of the origin, development, and history of the Nobel Peace Prize, with special focus on U.S. winners. Includes six suggested student projects and a list of U.S. Nobel Peace Prize winners. (CFR)

  12. Shirin Ebadi: A Muslim Woman Nobel Peace Laureate

    ERIC Educational Resources Information Center

    Ahmad, Iftikhar

    2004-01-01

    The Nobel Peace Prize is recognized as one of the most prestigious global awards. Each year the Norwegian Nobel Committee, which is appointed by Norway's parliament to select the winner, receives many nominations from around the world. Shirin Ebadi, who is from Iran, became the eleventh female Nobel Peace laureate in 2003. Ebadi is the third…

  13. Gender and Science: Women Nobel Laureates

    ERIC Educational Resources Information Center

    Charyton, Christine; Elliott, John O.; Rahman, Mohammed A.; Woodard, Jeness L.; DeDios, Samantha

    2011-01-01

    Women and their creativity are underrepresented in science. To date, few women have been awarded the Nobel Prize in science. Eleven female Nobel laureates in physics, chemistry and physiology/medicine between 1901 and 2006 were compared with 37 males who received the Nobel Prize in the same area one year prior and one year after the women. Data…

  14. Herbert A. Simon: Nobel Prize in Economic Sciences, 1978.

    PubMed

    Leahey, Thomas H

    2003-09-01

    In 1978, Herbert A. Simon won the Nobel Prize in Economic Sciences, the same Nobel won by Daniel Kahneman in 2002. Simon's work in fact paved the way for Kahneman's Nobel. Although trained in political science and economics rather than psychology, Simon applied psychological ideas to economic theorizing. Classical and neoclassical economic theories assume that people are perfectly rational and strive to optimize economic outcomes. Simon argued that human rationality is constrained, not perfect, and that people seek satisfactory rather than ideal outcomes. Despite his Nobel, Simon felt isolated in economics and ultimately moved into psychology. Nevertheless, his ideas percolated through the economic community, so that Kahneman, whose research advanced Simon's broad perspective, could be the psychologist who won the Nobel in economics.

  15. The first year as a neophyte RSO at a liberal arts college.

    PubMed

    Sowa, J R

    1999-11-01

    Union College is a small liberal arts college in the northeast with a good reputation in science. It is also one of the oldest schools in the nation, having been founded in 1795. Langmuir and Steinmetz taught here as did Chandler, the founder of the American Chemical Society and Ellery, one of the longest tenured Secretaries of Sigma Xi. Arthur and Carter became U.S. Presidents. We claim a Nobel Prize winner, the inventor of transistors, the person who developed the methods for producing quartz crystals and fiber optics. The presidents of du Pont and Kodak attended Union College. We are referred to as the "Mother of Fraternities," and we had the first radio station on a college campus (although not through the airways). Still, until recently, our reputation has been less than admirable among radiation safety experts. This article highlights some of the experiences of a new RSO at this well-acknowledged institution.

  16. Department of Energy - Nobel Prize in Chemistry News Release 10/5/2005

    Science.gov Websites

    -Supported Researchers Are Co-Winners of 2005 Nobel Prize in Chemistry Secretary of Energy Samuel W. Bodman . Grubbs of the California Institute of Technology for co-winning the 2005 Nobel Prize in Chemistry. " . Schrock and Yves Chauvin of France for winning the 2005 Nobel Prize in Chemistry for their discoveries

  17. Sources of funding for Nobel Prize-winning work: public or private?

    PubMed

    Tatsioni, Athina; Vavva, Effie; Ioannidis, John P A

    2010-05-01

    Funding is important for scientists' work and may contribute to exceptional research outcomes. We analyzed the funding sources reported in the landmark scientific papers of Nobel Prize winners. Between 2000 and 2008, 70 Nobel laureates won recognition in medicine, physics, and chemistry. Sixty five (70%) of the 93 selected papers related to the Nobel-awarded work reported some funding source including U.S. government sources in 53 (82%), non-U.S. government sources in 19 (29%), and nongovernment sources in 33 (51%). A substantial portion of this exceptional work was unfunded. We contacted Nobel laureates whose landmark papers reported no funding. Thirteen Nobel laureates responded and offered their insights about the funding process and difficulties inherent in funding. Overall, very diverse sources amounting to a total of 64 different listed sponsors supported Nobel-related work. A few public institutions, in particular the U.S. National Institutes of Health (with n=26 funded papers) and the National Science Foundation (with n=17 papers), stood out for their successful record for funding exceptional research. However, Nobel-level work arose even from completely unfunded research, especially when institutions offered a protected environment for dedicated scientists.

  18. The image of the Nobel Prize.

    PubMed

    Källstrand, Gustav

    2018-05-01

    This article traces the origins of the Nobel Prize as a ubiquitous symbol of excellence in science. The public image of the Nobel Prize was created and became established quickly, which can be explained by it being such a useful phenomenon for the co-production of other values and ideas such as national prestige. Through being an easily recognizable symbol for excellence, the Nobel Prize is an important factor for the public image of science. And the image of the Nobel Prize is co-produced with several other sets of values and images that range from the large and thematic to the local and specific.

  19. The Underpinnings of American Foreign Policy

    DTIC Science & Technology

    2010-03-01

    speeches , those given in December 2009, first at the United States Military Academy at West Point and later as he accepted his Nobel Peace Prize... speeches , those given in December 2009, first at the United States Military Academy at West Point and later as he accepted his Nobel Peace Prize...Nobel Acceptance Speech , December 10th, 2009. President Obama’s Nobel Peace Prize acceptance speech in December, 2009, dismayed many of his

  20. Is the Nobel Prize good for science?

    PubMed

    Casadevall, Arturo; Fang, Ferric C

    2013-12-01

    The Nobel Prize is arguably the best known and most prestigious award in science. Here we review the effect of the Nobel Prize and acknowledge that it has had many beneficial effects on science. However, ever since its inaugural year in 1901, the Nobel Prize has also been beset by controversy, mostly involving the selection of certain individuals and the exclusion of others. In this regard, the Nobel Prize epitomizes the winner-takes-all economics of credit allocation and distorts the history of science by personalizing discoveries that are truly made by groups of individuals. The limitation of the prize to only 3 individuals at a time when most scientific discovery is the result of collaborative and cooperative research is arguably the major cause of Nobel Prize controversies. A simple solution to this problem would be to eliminate the restriction on the number of individuals who could be awarded the prize, a measure that would recognize all who contribute, from students to senior investigators. There is precedent for such a change in the Nobel Peace Prize, which has often gone to organizations. Changing the Nobel Prize to more fairly allocate credit would reduce the potential for controversy and directly benefit the scientific enterprise by promoting cooperation and collaboration of scientists within a field to reduce the negative consequences of competition between individual scientists.

  1. Global and local "teachable moments": The role of Nobel Prize and national pride.

    PubMed

    Baram-Tsabari, Ayelet; Segev, Elad

    2018-05-01

    This study examined to what extent Nobel Prize announcements and awards trigger global and local searches or "teachable moments" related to the laureates and their discoveries. We examined the longitudinal trends in Google searches for the names and discoveries of Nobel laureates from 2012 to 2017. The findings show that Nobel Prize events clearly trigger more searches for laureates, but also for their respective discoveries. We suggest that fascination with the Nobel prize creates a teachable moment not only for the underlying science, but also about the nature of science. Locality also emerged as playing a significant role in intensifying interest.

  2. ["In Stockholm they apparently had some kind of countermovement" - Ferdinand Sauerbruch (1875-1951) and the Nobel prize].

    PubMed

    Hansson, Nils; Schagen, Udo

    2014-01-01

    The archive of the Nobel Assembly for Physiology or Medicine in Solna, Sweden, is a remarkable repository that contains reports and dossiers of the Nobel Prize nominations of senior and junior physicians from around the world. Although this archive has begun to be used more by scholars, it has been insufficiently examined by historians of surgery. No other German surgeon was nominated as often as Ferdinand Sauerbruch for the Nobel Prize for Physiology or Medicine in the first half of the 20th century. This contribution reconstructs why and by whom Sauerbruch was nominated, and discusses the Nobel committee evaluations of his work. Political factors did not play an obvious role in the Nobel committee discussions, in spite of the fact that Adolf Hitler in 1937 had prohibited all German citizens to accept the Nobel Prize. The main reasons why Sauerbruch ultimately was not considered prize- worthy were that Sauerbruch's achievements were marked by scientific priority disputes, and that his work was not seen as original enough.

  3. Venkatraman Ramakrishnan, Thomas A. Steitz, Ada E. Yonath, and Ribosome

    Science.gov Websites

    'studies of the structure and function of the ribosome", the 2009 Nobel Prize in Chemistry has been ORNL Researcher Wins Nobel Prize Oak Ridge National Laboratory Ex-ORNL Researcher Wins Nobel Prize

  4. Nobel prizes: contributions to cardiology.

    PubMed

    Mesquita, Evandro Tinoco; Marchese, Luana de Decco; Dias, Danielle Warol; Barbeito, Andressa Brasil; Gomes, Jonathan Costa; Muradas, Maria Clara Soares; Lanzieri, Pedro Gemal; Gismondi, Ronaldo Altenburg

    2015-08-01

    The Nobel Prize was created by Alfred Nobel. The first prize was awarded in 1901 and Emil Adolf von Behring was the first laureate in medicine due to his research in diphtheria serum. Regarding cardiology, Nobel Prize's history permits a global comprehension of progress in pathophysiology, diagnosis and therapeutics of various cardiac diseases in last 120 years. The objective of this study was to review the major scientific discoveries contemplated by Nobel Prizes that contributed to cardiology. In addition, we also hypothesized why Carlos Chagas, one of our most important scientists, did not win the prize in two occasions. We carried out a non-systematic review of Nobel Prize winners, selecting the main studies relevant to heart diseaseamong the laureates. In the period between 1901 and 2013, 204 researches and 104 prizes were awarded in Nobel Prize, of which 16 (15%) studies were important for cardiovascular area. There were 33 (16%) laureates, and two (6%) were women. Fourteen (42%) were American, 15 (45%) Europeans and four (13%) were from other countries. There was only one winner born in Brazil, Peter Medawar, whose career was all in England. Reviewing the history of the Nobel Prize in physiology or medicine area made possible to identify which researchers and studies had contributed to advances in the diagnosis, prevention and treatment of cardiovascular diseases. Most winners were North Americans and Europeans, and male.

  5. Formula one night race in Singapore: a 4-year analysis of a planned mass gathering.

    PubMed

    Ho, Weng Hoe; Koenig, Kristi L; Quek, Lit Sin

    2014-10-01

    Every mass gathering presents its unique characteristics that influence medical resource utilization. Medical planning for mass gatherings involves both use of predictive models and analysis of data from similar past events. This study aimed to describe the medical presentations and the unique challenges influencing medical planning at the Formula One Singtel Singapore Grand Prix, the inaugural Formula One night race. Patient presentation characteristics, rates of patient presentation, and transportation to hospitals in association with attendance and heat index were evaluated over a 4-year period from 2009 through 2012. This will facilitate medical planning for similar events. A database containing patient presentations from the 3-day Singapore Grand Prix in 2009, 2010, 2011, and 2012 was analyzed. Patient presentations were categorized by time of day and presenting complaints. Patient presentation rates (PPRs) were analyzed to determine correlation with attendance numbers and heat index. The average annual attendance at the Singapore Grand Prix was 81,992 from 2009 through 2012. The average PPR was 2.17 (SD=0.63)/1,000 attendees. The average transport to hospital rate (TTHR) was 0.033 (SD=0.026)/1,000 attendees. While medical coverage was provided at the circuit park between 2:00 pm to 1:00 am daily, most attendees presented from 5:00 pm to 10:00 pm. The most common presenting complaints included: musculoskeletal conditions (59%) and heat related illnesses (19%). There was no correlation between attendance numbers and PPR and the heat index and PPR. Musculoskeletal conditions and heat-related illnesses were the most common presenting complaints at the Singapore Grand Prix from 2009-2012. The lack of correlation between heat index and PPR is a new finding compared with prior studies. This could be due to the minimal heat variation that occurred during the night event. Further study is required to refine models that can be used in specialized events.

  6. [The first three Nordic Nobel laureates in physiology or medicine].

    PubMed

    Pernow, B

    1997-01-01

    Among all the Nobel Laureates in physiology or medicine there are five from Denmark and seven from Sweden. The first three Laureates are presented in this paper. Over 50 years have elapsed since they were awarded and the Nobel archives are now open for scrutiny, providing insight into how the Nobel committee interpreted the instruction given in Nobel's will at that time. Niels Finsen (1860-1904, Nobel Laureate 1903) devoted his short life to a continuous study of the biological effects of sunshine, which resulted in a method aimed at utilizing the bacteriocide properties of sun rays in the treatment of various skin diseases and especially tuberculosis. Finsen published his first paper on this topic in 1896 and his method revolutionized the current treatment of this disease. Approximately forty Finsen Institutes were established in Europe and the USA within the subsequent five years. Alvar Gullstrand (1869-1930, Nobel Laureate 1911) was an ophthalmologist but his main interest was mathematical physics, where he achieved results of utmost importance for clinical opthalmology. He systematically studied the optical system, from the physical properties of light rays to optimal images in different media of the eye. He formulated general laws if image, which he extrapolated to the human eye. He also devised several techniques, some of which still used in ophthalmology. August Krogh (1874-1949, Nobel Laureate 1920) was a zoological physiologist, actively involved in various fields, including human muscle physiology and metabolism, capillary circulation in the frog, water regulation in the desert rat and the jumping capacity of the grasshopper. He was the founder of modern human exercise physiology and sport medicine. Krogh received the Nobel prize the year after he published his first paper on the regulation of the motor activity of capillaries, which reflected the Nobel committee's desire at that time to support a young scientist in the most successul period of his career. Through his continuous brilliant research during three decades Krogh eminently demonstrated that the committee had indeed use far-sighted judgement.

  7. [Surgeons and Neurosurgeons as Nobel Prize Winners].

    PubMed

    Chrastina, Jan; Jančálek, Radim; Hrabovský, Dušan; Novák, Zdeněk

    Since 1901 Nobel Prize is awarded for exceptional achievements in physics, chemistry, literature, peace, economy (since 1968) and medicine or physiology. The first aim of the paper is to provide an overview of surgeons - winners of Nobel Prize for medicine or physiology. Although the prominent neurosurgeons were frequently nominated as Nobel Prize candidates, surprisingly no neurosurgeon received this prestigious award so far despite that the results of their research transgressed the relatively narrow limits of neurosurgical speciality.The most prominent leaders in the field of neurosurgery, such as Victor Horsley, Otfrid Foerster, Walter Dandy and Harvey Cushing are discussed from the point of their nominations. The overview of the activity of the Portuguese neurologists and Nobel Prize Winter in 1949 Egas Moniz (occasionally erroneously reported as neurosurgeon) is also provided. Although his work on brain angiography has fundamentally changed the diagnostic possibilities in neurology and neurosurgery, he was eventually awarded Nobel Prize for the introduction of the currently outdated frontal lobotomy.The fact that none of the above mentioned prominent neurosurgeons has not been recognised by Nobel Prize, may be attributed to the fact that their extensive work cannot be captured in a short summary pinpointing its groundbreaking character.

  8. An Astrosocial Observation: The Nobel Connection to the Space Program

    NASA Technical Reports Server (NTRS)

    Ng, Edward W.; Nash, Rebecca L.

    2007-01-01

    The 2006 Nobel Prize in Physics was heralded by some in the press as the 'First Nobel Prize for Space Exploration.' Indeed the Nobel Foundation's announcement specifically cited the Cosmic Background Explorer (COBE) satellite launched by NASA in 1989 as the prime-enabling instrument It elaborated further, 'The COBE results provided increased support for the Big Bang scenario for the origin of the Universe... These measurements also marked the inception of cosmology as a precise science.' NASA also seized this unique moment of fame to honor its favorite son, the first Nobel scientist of the agency, John Mather, of the Goddard Space Flight Center, who shared the honor with Professor G. Smoot of the University of California, the Principal Investigator of the COBE measurement. It is without any dispute that the Nobel Prize is the highest scientific honor and best-known award of admiration and inspiration to the public and educational sectors. Unfortunately in the American culture, youths are mostly exposed to success icons in the sports, entertainment, and business domains. Science icons (of either gender) are largely unknown to them. We sincerely hope that success stories of Nobel scientists will become part of the learning curriculum in the K-16 educational experience. In this paper, we examine the pedigree of a number of Nobel Prizes over the years, and discuss their interactions with, and connections to, the space program. It is advantageous for the context of educational and public outreach to see such connections, because in a number of public surveys, one important customer expectation for the space program is the search for new knowledge, to which the Nobel Prize is a prominent benchmark.

  9. [The Nobel Prize database as an indicator of the internationalization of Brazilian science from 1901 to 1966].

    PubMed

    Pittella, José Eymard Homem

    2018-01-01

    Working with the Nobel Prize database, covering 1901-1966, the article examines the analytical potential of the participation of Brazilians both as nominees for the world's most prestigious award in science, the Nobel Prize, and also as invited nominators. Of the 18 Brazilians nominated for the Nobel, nine were in the category Peace, four in Literature, four in Physiology or Medicine, and one in Physics. The article comments on the nominations of Brazilian scientists in the categories of Physics and Physiology or Medicine, as well as on nominations by Brazilian nominators in these same two categories. It also discusses the process of science evaluation, based on the information attained through analysis of these data on the Nobel award.

  10. Synthesis and the Nobel Prize in Chemistry

    NASA Astrophysics Data System (ADS)

    Seeman, Jeffrey I.

    2017-10-01

    The question often arises as to who may have deserved a Nobel Prize but was not awarded one. Rarely is this discussion extended to who should have received more than one Nobel Prize, but in the field of organic synthesis there are some compelling candidates.

  11. [On the Awarding of the First Nobel Prize for Physiology or Medicine to Emil von Behring].

    PubMed

    Hansson, Nils; Enke, Ulrike

    2015-12-01

    In his will of 1895, the Swedish inventor Alfred Nobel laid the foundation for prizes in physics, chemistry, physiology or medicine, literature, and peace to those who had "conferred the greatest benefit on mankind" during the last year. The Nobel Prize is today widely considered as the most prestigious international symbol of scientific excellence, but it still is an exciting research question how it gained such prestige. Drawing on files from the Emil von Behring Archive in Marburg, Germany, and the Archive of the Nobel Assembly for Physiology or Medicine in Stockholm this essay aims at shedding light on why the first Nobel Prize for Physiology or Medicine in 1901 was awarded the German immunologist Emil von Behring, and how this decision was viewed at that time. This study is part of a research project that explores mechanisms leading to scientific recognition by using the example of the Nobel Prize for Physiology or Medicine. © Georg Thieme Verlag KG Stuttgart · New York.

  12. ["If Berger had survived the second world war - he certainly would have been a candidate for the Nobel Prize". Hans Berger and the legend of the Nobel Prize].

    PubMed

    Gerhard, U-J; Schönberg, A; Blanz, B

    2005-03-01

    The public opinion pays much attention to the Nobel Prize as an indicator for the scientific efficiency of a university or a country in connection with foundation of so-called elite universities. The former holder of the psychiatric chair in Jena and discoverer of the electroencephalogram Hans Berger (1873 - 1941) came into discussion as candidate for the Nobel Prize in physiology or medicine. The current medical-historical publications maintain the view that Berger should have received the Nobel Prize in 1936 as well as in 1949. This was prevented in 1936 by an enactment from Hitler, which forbid him to accept the prize, and later in 1949 by Berger's own death. According to documents of the Nobel archives these statements can be disproved. Berger was only nominated three times out of 65 nominations in 1940. Because of his death the other two recommendations in 1942 and 1947 were never evaluated.

  13. Isotopic micro generators 1 volt; Les microgenerateurs radioisotopiques 1 volt (in French)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bomal, R.; Devin, B.; Delaquaize, P.

    1969-07-01

    Various configurations for electrical isotopic generators in the milliwatt range are investigated; these generators are not of the classical thermoelectric type. The four following energy conversion method are examined : thermionic, thermo-photovoltaic, radio-voltaic, wired thermoelectric. The calculus has been conducted having in view not the best energy conversion efficiency, but the need to attain directly 1 volt output voltage. High temperature {sup 238}Pu sources (T above 1000 ) are isolated by multi layer thermal insulation material of the Moly/Alumina type. Optimised application is given for number 1 and 2 here above. Thermionic is interesting by its compactness and Wired-thermoelectric ismore » cheap, simple and rugged. Both method do not allow to extend output voltage range far above 1 volt. TPV and RV, can be designed for multi volt application. Radio-voltaic is 1 per cent efficient but irradiation defects in the semiconductor induced by high energy radiations can strongly limit the lifetime of the generator. Isotope sources technology is the determining factor for these micro generators. (author) [French] Cette etude examine les types de generateurs electriques realisables a partir de sources isotopiques en dehors du procede thermoelectrique classique. Les quatre procedes suivants sont examines: thermoionique, thermophoto-voltaique, radiovoltaique, thermoelectrique a fils. Les calculs sont conduits sans souci exagere du rendement de conversion pour aboutir a une puissance electrique delivree de 0,2 a 1 mW sous une tension au moins egale a 1 volt. Le probleme des sources thermiques de {sup 238}Pu a haute temperature (T > 1000 C) est resolu avec une isolation a structure multi-couche moly-alumine. L'optimalisation est calculee en vue d'une utilisation dans les procedes 1 et 2. Le procede 1 est interessant par sa compacite et le procede 4 par sa simplicite, sa robustesse et son prix de revient; mais avec ces deux generateurs on ne peut obtenir plus d'un volt en charge. Les procedes 2 et 3 peuvent delivrer des tensions de plusieurs volts. Le radiovoltaique donne des rendements de 1 pour cent, mais la creation de defauts dans le reseau cristallin du semiconducteur avec les particules de grande energie peut limiter son utilisation. Les performances de ces differents modes de conversion sont conditionnees avant tout par les technologies des sources isotopiques. (auteur)« less

  14. L’enclouage centromédullaire dans les fractures complexes de l’extrémité supérieure de l’humérus: résultats préliminaire à propos de 6 cas

    PubMed Central

    Jamal, Louaste; Cherrad, Taoufik; Bousbaa, Hicham; Wahidi, Mohammed; Amhajji, Larbi; Rachid, Khalid

    2016-01-01

    L’enclouage centromédullaire antérograde s’est imposé comme un des traitements de référence des fractures céphalotubérositaires à deux, trois et quatre fragments. Nous présentons une étude rétrospective de 06 patients ayant bénéficié d’un enclouage centromédullaire depuis janvier 2012. Le Recul moyen est de 12 mois, l’âge moyen était de 57 ans. Evaluation clinique se basait sur le score de Constant et Murley, en brut et pondéré en fonction de l’âge et du sexe, avec un comparatif avec le coté sain. Le bilan radiologique nous a permis d’évaluer la consolidation osseuse, l’apparition d’Ostéonécrose de la tête ou arthrose post traumatique. Surveille aussi l’Etat des tubérosités avec l’existence ou non d’ostéolyse du trochiter. Elle recherche aussi les critères de bonne réduction à savoir l’angle calotte céphalique et l’axe diaphysaire (αF) sur les clichés de face. Tous les patients ont été traités selon la même technique chirurgicale. Le score de Constant et Murley sur l’ensemble des patients était de 64.13 points. Le score pondéré en fonction de l’age et du sexe était de 73%. Les mobilités articulaires étaient en moyenne sur l’ensemble des patients 116° en élévation antérieure, 99.9° en élévation latérale, et 42° en rotation externe. Angle αF moyen s’élève à 42°. Tous les patients présentaient des critères de bonne réduction à savoir αF. L’enclouage centromédullaire permet une synthèse osseuse simple et au prix d’un abord limité avec des résultats fonctionnels très prometteurs. La comminution fracturaire et l’ostéoporose peuvent limiter ces indications. PMID:28250878

  15. Smoot Cosmology Group

    Science.gov Websites

    . Interview with 2006 Nobel Laureates in Physics: George Smoot and John Mather Interview excerpt with 2006 Nobel Prize Laureates in Physics John Mather and George Smoot answer a question from the public on how has their research effects everyday life. Nobel Prize in Physics, 2006 Cosmologist George F. Smoot led

  16. Yellow fever and Max Theiler: the only Nobel Prize for a virus vaccine

    PubMed Central

    Norrby, Erling

    2007-01-01

    In 1951, Max Theiler of the Rockefeller Foundation received the Nobel Prize in Physiology or Medicine for his discovery of an effective vaccine against yellow fever—a discovery first reported in the JEM 70 years ago. This was the first, and so far the only, Nobel Prize given for the development of a virus vaccine. Recently released Nobel archives now reveal how the advances in the yellow fever vaccine field were evaluated more than 50 years ago, and how this led to a prize for Max Theiler. PMID:18039952

  17. Blueprint for an Indian Nobel Laureate in Psychiatry*

    PubMed Central

    Singh, Ajai R.

    2015-01-01

    There are a number of spoofs and light-hearted writings in blogs, journalistic pieces and book form (even from former Nobel Laureates), which attempt at ‘understanding’ the secret of getting a Nobel. This is not one of them. It is more pedantic without necessarily being dry. It first analyses the meaning of the concept, ‘the greatest benefit of mankind’, which is the crux of the Nobel Will and the overarching requirement for a Nobel in Medicine. Further discussion in the paper is divided into 5 parts: (1)General qualities for a Nobel: The need to be really bright is a given; what is necessary is to be sufficiently crazy about a research topic to make it an obsession; be ready to forgo many creature comforts for long stretches of time; and after all this, be ready to accept that the Nobel may never happen, yet continue to do a type of research solely because it is intrinsically worth doing.(2)Nobel in Physiology or Medicine: Here, the key is to do fundamental/basic research to answer persistent, nagging, unanswered questions of medicine which others neglect because they are discomforting. Or, find treatments that change the whole manner a disease has been hitherto treated.(3)Nobel in Psychiatry: There are many Nobels waiting to be won, provided: (a) The branch becomes more precise; (b) Science, quantitative study and biology remain its bedrock; and (c) There is an almost obsessive preoccupation with unravelling the mysteries of the brain. One has to choose wisely where to put in efforts, e.g., fields like fundamental research into the causes of psychiatric disorders, especially schizophrenia, depression, bipolar disorders. Or their definitive treatments. Or, work at the cellular or molecular level of the neuron and brain; or, the glandular or genetic level of the systems connected with psychiatric disorders; or, in brain radio imaging. If other, or allied, fields are chosen, to work with finding quantitative data and attempt to pinpoint their precise biological correlates.(4)Indian Nobel in Medicine: There is first the need to give up the colonial mindset that everything trend-setting in science comes only from the West. As also, for Departmental Heads, to protect and nurture those with research excellence rather than the mediocre and the sycophants. For governments, to set up an autonomous Research Excellence Council to expressly and exclusively cater to promoting research excellence, with a sizeable fund to put this into practice.All these four points are summarised as four rules.(5)Indian Nobel in psychiatry: Practical suggestions are presented in the form of an 11 Point Action Plan based on 1-4 above. PMID:25838739

  18. The Alfred Nobel rocket camera. An early aerial photography attempt

    NASA Astrophysics Data System (ADS)

    Ingemar Skoog, A.

    2010-02-01

    Alfred Nobel (1833-1896), mainly known for his invention of dynamite and the creation of the Nobel Prices, was an engineer and inventor active in many fields of science and engineering, e.g. chemistry, medicine, mechanics, metallurgy, optics, armoury and rocketry. Amongst his inventions in rocketry was the smokeless solid propellant ballistite (i.e. cordite) patented for the first time in 1887. As a very wealthy person he actively supported many Swedish inventors in their work. One of them was W.T. Unge, who was devoted to the development of rockets and their applications. Nobel and Unge had several rocket patents together and also jointly worked on various rocket applications. In mid-1896 Nobel applied for patents in England and France for "An Improved Mode of Obtaining Photographic Maps and Earth or Ground Measurements" using a photographic camera carried by a "…balloon, rocket or missile…". During the remaining of 1896 the mechanical design of the camera mechanism was pursued and cameras manufactured. In April 1897 (after the death of Alfred Nobel) the first aerial photos were taken by these cameras. These photos might be the first documented aerial photos taken by a rocket borne camera. Cameras and photos from 1897 have been preserved. Nobel did not only develop the rocket borne camera but also proposed methods on how to use the photographs taken for ground measurements and preparing maps.

  19. Osseointegration of three-dimensional designed titanium implants manufactured by selective laser melting.

    PubMed

    Shaoki, Algabri; Xu, Jia-Yun; Sun, Haipeng; Chen, Xian-Shuai; Ouyang, Jianglin; Zhuang, Xiu-Mei; Deng, Fei-Long

    2016-10-27

    The selective laser melting (SLM) technique is a recent additive manufacturing (AM) technique. Several studies have reported success in the SLM-based production of biocompatible orthopaedic implants and three-dimensional bone defect constructs. In this study, we evaluated the surface properties and biocompatibility of an SLM titanium implant in vitro and compared them with those of a machined (MA) titanium control surface. In addition, we evaluated the osseointegration capability of the SLM implants in vivo and compared it with those of MA and Nobel-speedy (Nobel-S) implants. SLM microtopographical surface analysis revealed porous and high roughness with varied geometry compared with a smooth surface in MA Ti samples but with similar favourable wettability. Osteoblast proliferation and alkaline phosphatase activity were significantly enhanced on the SLM surface. Histological analysis of the bone-implant contact ratio revealed no significant difference among SLM, MA, and Nobel-S implants. Micro-CT assessment indicated that there was no significant difference in bone volume fraction around the implant among SLM implants and other types of surface modification implants. The removal torque value measurement of SLM implants was significantly lower that of than Nobel-S implants P < 0.001 and higher than that of MA implants. The study demonstrates the capability of SLM implants to integrate with living bone. The SLM technique holds promise as a new dental implant manufacturing technique.

  20. Evaluation of three different validation procedures regarding the accuracy of template-guided implant placement: an in vitro study.

    PubMed

    Vasak, Christoph; Strbac, Georg D; Huber, Christian D; Lettner, Stefan; Gahleitner, André; Zechner, Werner

    2015-02-01

    The study aims to evaluate the accuracy of the NobelGuide™ (Medicim/Nobel Biocare, Göteborg, Sweden) concept maximally reducing the influence of clinical and surgical parameters. Moreover, the study was to compare and validate two validation procedures versus a reference method. Overall, 60 implants were placed in 10 artificial edentulous mandibles according to the NobelGuide™ protocol. For merging the pre- and postoperative DICOM data sets, three different fusion methods (Triple Scan Technique, NobelGuide™ Validation software, and AMIRA® software [VSG - Visualization Sciences Group, Burlington, MA, USA] as reference) were applied. Discrepancies between the virtual and the actual implant positions were measured. The mean deviations measured with AMIRA® were 0.49 mm (implant shoulder), 0.69 mm (implant apex), and 1.98°mm (implant axis). The Triple Scan Technique as well as the NobelGuide™ Validation software revealed similar deviations compared with the reference method. A significant correlation between angular and apical deviations was seen (r = 0.53; p < .001). A greater implant diameter was associated with greater deviations (p = .03). The Triple Scan Technique as a system-independent validation procedure as well as the NobelGuide™ Validation software are in accordance with the AMIRA® software. The NobelGuide™ system showed similar or less spatial and angular deviations compared with others. © 2013 Wiley Periodicals, Inc.

  1. Following Zahka: Using Nobel Prize Winners' Speeches and Ideas to Teach Economics

    ERIC Educational Resources Information Center

    Shanahan, Martin P.; Wilson, John K.; Becker, William E.

    2012-01-01

    Over 20 years ago, the late William Zahka (1990, 1998) outlined how the acceptance speeches of those who received the Nobel Memorial Prize in Economic Science could be used to teach undergraduates. This article updates and expands Zahka's work, identifying some of the issues discussed by recent Nobel Laureates, classifying their speeches by topic…

  2. The Nobel Prize in the Physics Class: Science, History, and Glamour

    ERIC Educational Resources Information Center

    Eshach, Haim

    2009-01-01

    This paper introduces a novel strategy for teaching physics: using the Nobel Physics Prize as an organizational theme for high school or even first year university physics, bringing together history, social contexts of science, and central themes in modern physics. The idea underlying the strategy is that the glamour and glitter of the Nobel Prize…

  3. 78 FR 48649 - Purified Carboxymethylcellulose From the Netherlands: Preliminary Results of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... producers/exporters of the subject merchandise, Akzo Nobel Functional Chemicals, B.V. (Akzo Nobel) and CP Kelco, B.V. (CP Kelco). We preliminarily determine that sales of subject merchandise by Akzo Nobel were made at less than normal value and CP Kelco had no shipments of subject merchandise during the POR...

  4. The Nobel Connection to the Space Program

    NASA Astrophysics Data System (ADS)

    Ng, E. N.; Nash, R. L.

    2007-09-01

    The 2006 Nobel Prize in Physics was heralded by some in the press as the "First Nobel Prize for Space Exploration." Indeed the Nobel Foundation's announcement specifically cited the Cosmic Background Explorer (COBE) satellite launched by NASA in 1989 as the prime-enabling instrument It elaborated further, "The COBE results provided increased support for the Big Bang scenario for the origin of the Universe. These measurements also marked the inception of cosmology as a precise science." NASA also seized this unique moment of fame to honor its favorite son, the first Nobel scientist of the agency, John Mather, of the Goddard Space Flight Center, who shared the honor with Professor G. Smoot of the University of California, the Principal Investigator of the COBE measurement. It is without any dispute that the Nobel Prize is the highest scientific honor and best-known award of admiration and inspiration to the public and educational sectors. Unfortunately in the American culture, youths are mostly exposed to success icons in the sports, entertainment, and business domains. Science icons are largely unknown to them. We sincerely hope that success stories of Nobel scientists will become part of the learning curriculum in the K-16 educational experience. In this paper, we examine the pedigree of a number of Nobel Prizes over the years, and discuss their interactions with, and connections to, the space program. It is advantageous for the context of educational and public outreach to see such connections, because in a number of public surveys, one important customer expectation for the space program is the search for new knowledge, to which the Nobel Prize is a prominent benchmark. We have organized this lengthy paper into nine, fairly independent sections for ease of reading:1."Michael Jordan or Mia Hamm" - Introduction and Background2."Connecting the Dots Between the Heavens and Earth" - From Newton to Bethe3."From Cosmic Noise to the Big Bang" - The First Nobel Recognition about Space Exploration4."Gone with the Win d" - Ozone Depletion Galore5."The Great Observatories" - From Einstein to Spitzer6."And the Winner is: Chandra" - How an Unpronounceable Name Won Over the Household Name "Mother X-ray"7."From the Mother of X-ray to the Father of X-ray Astronomy"8."To Catch a Ghost" - Hunting for That Elusive Cosmic Messenger9."The Stars Spell Your Name" - Christa's 73 Seconds in Space!Reprint can be downloaded from http://www.geocities.com/edw_ng/ -- reference link entitled "Nobel Connection"

  5. Supernovae, Dark Energy and the Accelerating Universe: How DOE Helped to Win (yet another) Nobel Prize

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Perlmutter, Saul

    2012-01-13

    The Department of Energy (DOE) hosted an event Friday, January 13, with 2011 Physics Nobel Laureate Saul Perlmutter. Dr. Perlmutter, a physicist at the Department’s Lawrence Berkeley National Laboratory and a professor of physics at the University of California at Berkeley, won the 2011 Nobel Prize in Physics “for the discovery of the accelerating expansion of the Universe through observations of distant supernovae.” DOE’s Office of Science has supported Dr. Perlmutter’s research at Berkeley Lab since 1983. After the introduction from Secretary of Energy Steven Chu, Dr. Perlmutter delivered a presentation entitled "Supernovae, Dark Energy and the Accelerating Universe: Howmore » DOE Helped to Win (yet another) Nobel Prize." [Copied with editing from DOE Media Advisory issued January 10th, found at http://energy.gov/articles/energy-department-host-event-2011-physics-nobel-laureate-saul-perlmutter]« less

  6. Vision and the Nobel Prize.

    PubMed

    Morais, Fábio Barreto

    2018-04-01

    The Nobel Prize is the world's foremost honor for scientific advances in medicine and other areas. Founded by Alfred Nobel, the prizes have been awarded annually since 1901. We reviewed the literature on persons who have won or competed for this prize in subjects related to vision and ophthalmology. The topics were divided into vision physiology, diagnostic and therapeutic methods, disease mechanism, and miscellaneous categories. Allvar Gullstrand is the only ophthalmologist to win a Nobel Prize; he is also the only one to receive it for work in ophthalmology. Other ophthalmologists that have been nominated were Hjalmar Schiötz (tonometer), Karl Koller (topical anesthesia), and Jules Gonin (retinal detachment). Other scientists have won the prize for eye-related research: Ragnar Granit, Haldan Hartline and George Wald (chemistry and physiology of vision), and David Hubel and Torsten Wiesel (processing in the visual system). Peter Medawar is the only person born in Brazil to have won the Nobel Prize.

  7. Berkeley Lab's Saul Perlmutter wins Nobel Prize in Physics | Berkeley Lab

    Science.gov Websites

    astrophysics, dark energy, physics Connect twitter instagram LinkedIn facebook youtube This form needs Berkeley Lab's Saul Perlmutter wins Nobel Prize in Physics News Release Paul Preuss 510-486-6249 * October professor of physics at the University of California at Berkeley, has won the 2011 Nobel Prize in Physics

  8. Researcher Supported by Atomic Energy Commission and U.S. Department of

    Science.gov Websites

    Energy is Co-Winner Of 2008 Nobel Prize in Physics October 7, 2008 Researcher Supported by Atomic Energy Commission and U.S. Department of Energy is Co-Winner Of 2008 Nobel Prize in Physics -winning the 2008 Nobel Prize in Physics for their theoretical insights that provide a deeper understanding

  9. Nobel Connection to the Space Program

    NASA Astrophysics Data System (ADS)

    Ng, Edward W.; Nash, Rebecca

    2007-09-01

    The 2006 Nobel Prize in Physics was heralded by some in the press as the "First Nobel Prize for Space Exploration." Indeed the Nobel Foundation's announcement specifically cited the Cosmic Background Explorer (COBE) satellite launched by NASA in 1989 as the prime-enabling instrument It elaborated further, "The COBE results provided increased support for the Big Bang scenario for the origin of the Universe... These measurements also marked the inception of cosmology as a precise science." NASA also seized this unique moment of fame to honor its favorite son, the first Nobel scientist of the agency, John Mather, of the Goddard Space Flight Center, who shared the honor with Professor G. Smoot of the University of California, the Principal Investigator of the COBE measurement. It is without any dispute that the Nobel Prize is the highest scientific honor and best-known award of admiration and inspiration to the public and educational sectors. Unfortunately in the American culture, youths are mostly exposed to success icons in the sports, entertainment, and business domains. Science icons (of either gender) are largely unknown to them. We sincerely hope that success stories of Nobel scientists will become part of the learning curriculum in the K-16 educational experience. In this paper, we examine the pedigree of a number of Nobel Prizes over the years, and discuss their interactions with, and connections to, the space program. It is advantageous for the context of educational and public outreach to see such connections, because in a number of public surveys, one important customer expectation for the space program is the search for new knowledge, to which the Nobel Prize is a prominent benchmark. We have organized this paper into nine, fairly independent sections for ease of reading: I. "Michael Jordan or Mia Hamm" - Introduction and Background II. "Connecting the Dots Between the Heavens and Earth" - From Newton to Bethe III. "From Cosmic Noise to the Big Bang" - The First Nobel Recognition about Space Exploration IV. "Gone with the Wind" - Ozone Depletion Galore V. "The Great Observatories" - From Einstein to Spitzer VI. "And the Winner is... Chandra" - How an Unpronounceable Name Won Over the Household Name "Mother X-ray" VII. "From the Mother of X-ray to the Father of X-ray Astronomy" VIII. "ToCatchaGhost" - Hunting for That Elusive Cosmic Messenger IX. "The Stars Spell Your Name" - Christa's 73 Seconds in Space

  10. Postage Stamps and Peace Education: The Nobel Peace Prize. Peace Education Miniprints No. 79.

    ERIC Educational Resources Information Center

    Abrams, Irwin

    This paper suggests how peace stamps can be used to further understanding of the movement for world peace. In this effort the Nobel Peace Prize, the most prestigious award in the world for peacemaking, is used as a focus. In the prizes from 1901 to the present, the Norwegian Nobel committees have recognized the major paths to peace. This variety…

  11. 33 CFR 100.1103 - Northern California annual marine events.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the parade route. Race the Straits Offshore Grand Prix Festival Sponsor Pacific Offshore Powerboat... Van Sickle Island and Chipps Island and returning to the point of origin. Festival of the Sea Sponsor...

  12. Chemistry in the News: 1998 Nobel Prizes in Chemistry and Medicine

    NASA Astrophysics Data System (ADS)

    Miller, Jennifer B.

    1999-01-01

    The Royal Swedish Academy of Sciences has awarded the 1998 Nobel Prize in Chemistry to Walter Kohn (University of California at Santa Barbara) for his development of the density-functional theory and to John A. Pople (Northwestern University at Evanston, Illinois) for his development of computational methods in quantum chemistry. The Nobel Assembly at the Karolinska Institute has awarded the 1998 Nobel Prize in Physiology or Medicine jointly to Robert F. Fuchgott (State University of New York Health Science Center at Brooklyn), Louis J. Ignarro (University of California at Los Angeles), and Ferid Murad (University of Texas Medical School at Houston) for identifying nitric oxide as a key biological signaling molecule in the cardiovascular system.

  13. Diagnostic value of NobelGuide to minimize the need for reconstructive surgery of jaws before implant placement: a review.

    PubMed

    Scotti, Roberto; Pellegrino, Gerardo; Marchetti, Claudio; Corinaldesi, Guiseppe; Ciocca, Leonardo

    2010-01-01

    To test if using a CAD/CAM system might reduce the necessity of bone augmentation in patients with atrophic maxillary arches before implant therapy. Twenty male and female patients consecutively scheduled for bone augmentation of the jaw before implant surgery were included in this study, with a total of 29 jaws (maxillary and mandibular) to analyze for the implant-supported fixed prosthesis group and 19 maxillary arches for the implant-supported removable prosthesis group. NobelGuide System (Nobel Biocare), Autocad System (Autodesk), and routine manual CT measurements of available bone were used in this study. The total results of the mean values of the fixed prosthesis group plus the mean values of the removable prosthesis group showed a statistically significant difference between the NobelGuide intervention score and both manual (P = .004) and Autocad (P = .001) measurements. The NobelGuide System represents a viable diagnostic device to reduce the entity or avoid bone reconstructive surgery before implant placements in the atrophic maxilla and mandible.

  14. Supernovae, Dark Energy and the Accelerating Universe: How DOE Helped to Win (yet another) Nobel Prize

    ScienceCinema

    Perlmutter, Saul; Chu, Steven

    2018-05-31

    The Department of Energy (DOE) hosted an event Friday, January 13, with 2011 Physics Nobel Laureate Saul Perlmutter. Dr. Perlmutter, a physicist at the Department’s Lawrence Berkeley National Laboratory and a professor of physics at the University of California at Berkeley, won the 2011 Nobel Prize in Physics “for the discovery of the accelerating expansion of the Universe through observations of distant supernovae.” DOE’s Office of Science has supported Dr. Perlmutter’s research at Berkeley Lab since 1983. After the introduction from Secretary of Energy Steven Chu, Dr. Perlmutter delivered a presentation entitled "Supernovae, Dark Energy and the Accelerating Universe: How DOE Helped to Win (yet another) Nobel Prize." [Copied with editing from DOE Media Advisory issued January 10th, found at http://energy.gov/articles/energy-department-host-event-2011-physics-nobel-laureate-saul-perlmutter

  15. Gore's Nobel May Bring Even More Attention on Campuses to Environmental Issues: Award for Combating Climate Change Implicitly Honors the Work of Academic Scientists

    ERIC Educational Resources Information Center

    Byrne, Richard; Monastersky, Richard

    2007-01-01

    When the Norwegian Nobel Committee announced that the 2007 Nobel Peace Prize would be shared by Al Gore, the former U.S. vice president, and the Intergovernmental Panel on Climate Change, the award implicitly celebrated a third party--academic institutions. Much of the research on global warming has come from university scientists, and higher…

  16. Why there should be more science Nobel prizes and laureates - And why proportionate credit should be awarded to institutions.

    PubMed

    Charlton, Bruce G

    2007-01-01

    The four science Nobel prizes (physics, chemistry, medicine/physiology and economics) have performed extremely well as a method of recognizing the highest level of achievement. The prizes exist primarily to honour individuals but also have a very important function in science generally. In particular, the institutions and nations which have educated, nurtured or supported many Nobel laureates can be identified as elite in world science. However, the limited range of subjects and a maximum of 12 laureates per year mean that many major scientific achievements remain un-recognized; and relatively few universities can gather sufficient Nobel-credits to enable a precise estimate of their different levels of quality. I advocate that the Nobel committee should expand the number of Nobel laureates and Prize categories as a service to world science. (1) There is a large surplus of high quality prize candidates deserving of recognition. (2) There has been a vast expansion of research with a proliferation of major sub-disciplines in the existing categories. (3) Especially, the massive growth of the bio-medical sciences has created a shortage of Nobel recognition in this area. (4) Whole new fields of major science have emerged. I therefore suggest that the maximum of three laureates per year should always be awarded in the categories of physics, chemistry and economics, even when these prizes are for diverse and un-related achievements; that the number of laureates in the 'biology' category of physiology or medicine should be increased to six or preferably nine per year; and that two new Prize categories should be introduced to recognize achievements in mathematics and computing science. Together, these measures could increase the science laureates from a maximum of 12 to a minimum of 24, and increase the range of scientific coverage. In future, the Nobel committee should also officially allocate proportionate credit to institutions for each laureate, and a historical task force could also award institutional credit for past prizes.

  17. [Posthumous nomination for Medicine Nobel Prizes II. The positivism era (1849-1899)].

    PubMed

    Cruz-Coke, R

    1997-06-01

    The author proposes the nomination of great physicians of the second half of the XIX century for a posthumous Medicine Nobel Prize. The valorization given by medical historians Garrison, Lavastine, Castiglioni, Lain Entralgo and Guerra, is used to select the better candidates. One to three names are assigned by year from 1849 to 1899. Four categories of Nobel prizes are assigned: a) Basic biological disciplines, b) Clinical and surgical medicine, pathology and specialties, c) Discoverers of transcendental diseases that are eponyms and d) New medical technologies. A total of 84 nominees for the Nobel Prize are presented. These lists are presented as preliminary and tentative to allow an extensive debate about the history of medicine during the nineteenth century.

  18. Muller's Nobel Prize Lecture: when ideology prevailed over science.

    PubMed

    Calabrese, Edward J

    2012-03-01

    This paper extends and confirms the report of Calabrese (Calabrese, E. J. (2011b). Muller's Nobel Lecture on dose-response for ionizing radiation: Ideology or science? Arch. Toxicol. 85, 1495-1498) that Hermann J. Muller knowingly made deceptive comments in his 1946 Nobel Prize Lecture (Muller, H. J. (1946). Nobel Prize Lecture. Stockholm, Sweden. Available at http://www.nobelprize.org/. Accessed December 12) concerning the dose-response. Supporting a linearity perspective, Muller stated there is "no escape from the conclusion that there is no threshold" while knowing the results of a recent study by Ernst Caspari and Curt Stern contradicted these comments. Recently uncovered private correspondence between Muller and Stern reveals Muller's scientific assessment of the Caspari and Stern manuscript in a letter from Muller to Stern 5 weeks (14 January 1947) after his Nobel Prize Lecture of 12 December 1946. Muller indicated that the manuscript was of acceptable scientific quality; he indicated the manuscript should be published, but the findings needed replication because it significantly challenged the linearity hypothesis. These findings complement the previous letter (12 November 1946 letter from Muller to Stern), which revealed that Muller received the Caspari and Stern manuscript, recognized it as significant, and recommended its replication 5 weeks before his Nobel Prize Lecture. Muller therefore supported this position immediately before and after his Nobel Prize Lecture. Muller's opinions on the Caspari and Stern manuscript therefore had not changed during the time leading up to his Lecture, supporting the premise that his Lecture comments were deceptive. These findings are of historical and practical significance because Muller's comments were a notable contributory factor, changing how risks would be assessed for carcinogens (i.e., changing from a threshold to a linear model) throughout the 20th century to the present.

  19. Nobel Prize Literature; A Selection of the Works of Forty-Four Nobel Prize Winning Authors in the Library of Dutchess Community College, with Biographical and Critical Sketches.

    ERIC Educational Resources Information Center

    Hubbard, Terry E., Comp.

    This bibliography is a compilation of works by 44 Nobel Prize winning authors presently available at the Dutchess Community College library. Each entry describes the piece of literature for which the author received an award, provides a brief sketch of the writer, includes a commentary on the themes of major works, and lists the writer's works. An…

  20. Introducing Taiwanese undergraduate students to the nature of science through Nobel Prize stories

    NASA Astrophysics Data System (ADS)

    Eshach, Haim; Hwang, Fu-Kwun; Wu, Hsin-Kai; Hsu, Ying-Shao

    2013-06-01

    Although there is a broad agreement among scientists and science educators that students should not only learn science, but also acquire some sense of its nature, it has been reported that undergraduate students possess an inadequate grasp of the nature of science (NOS). The study presented here examined the potential and effectiveness of Nobel Prize stories as a vehicle for teaching NOS. For this purpose, a 36-hour course, “Albert Einstein’s Nobel Prize and the Nature of Science,” was developed and conducted in Taiwan Normal University. Ten undergraduate physics students participated in the course. Analysis of the Views of Nature of Science questionnaires completed by the students before and after the course, as well as the students’ own presentations of Nobel Prize stories (with an emphasis on how NOS characteristics are reflected in the story), showed that the students who participated in the course enriched their views concerning all aspects of NOS. The paper concludes with some suggestions for applying the novel idea of using Nobel Prize stories in physics classrooms.

  1. 33 CFR 100.720 - Annual Suncoast Offshore Grand Prix; Gulf of Mexico, Sarasota, FL.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of the racecourse. All coordinates referenced use datum: NAD 83. (4) Big Sarasota Pass will be closed... datum: NAD 1983. (b) Special local regulations. (1) No anchoring will be permitted seaward of the...

  2. 33 CFR 100.720 - Annual Suncoast Offshore Grand Prix; Gulf of Mexico, Sarasota, FL.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... datum: NAD 1983. (b) Special local regulations. (1) No anchoring will be permitted seaward of the... of the racecourse. All coordinates referenced use datum: NAD 83. (4) Big Sarasota Pass will be closed...

  3. 77 FR 37808 - Special Local Regulation; East Tawas Offshore Gran Prix, Tawas Bay; East Tawas, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... race. This special local regulation will establish restrictions upon, and control movement of, vessels... result in serious injuries or fatalities. C. Discussion of Rule With the aforementioned hazards in mind...

  4. 33 CFR 100.720 - Annual Suncoast Offshore Grand Prix; Gulf of Mexico, Sarasota, FL.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of the racecourse. All coordinates referenced use datum: NAD 83. (4) Big Sarasota Pass will be closed... datum: NAD 1983. (b) Special local regulations. (1) No anchoring will be permitted seaward of the...

  5. 33 CFR 100.720 - Annual Suncoast Offshore Grand Prix; Gulf of Mexico, Sarasota, FL.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of the racecourse. All coordinates referenced use datum: NAD 83. (4) Big Sarasota Pass will be closed... datum: NAD 1983. (b) Special local regulations. (1) No anchoring will be permitted seaward of the...

  6. 33 CFR 100.720 - Annual Suncoast Offshore Grand Prix; Gulf of Mexico, Sarasota, FL.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of the racecourse. All coordinates referenced use datum: NAD 83. (4) Big Sarasota Pass will be closed... datum: NAD 1983. (b) Special local regulations. (1) No anchoring will be permitted seaward of the...

  7. The Role of United States Army Special Forces in Operation NOBEL OBELISK

    DTIC Science & Technology

    2001-06-01

    This thesis will examine U.S. Special Forces contributions to Operation NOBEL OBELISK, a Marine- led joint NEO in Sierra Leone in 1997. It is further...success of Joint Task Force NOBEL OBELISK. This operation led to the eventual safety of in excess of 2,500 civilians. Many of those civilians were... led many observers, both within and outside the country, to be optimistic about the future of democracy and the rule of law.”6 Unfortunately, twenty

  8. Nobel Prize in Physiology or Medicine

    MedlinePlus

    ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Quick Facts Nomination Nomination Physics Prize Chemistry ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Nomination Archive Ceremonies Ceremonies Ceremony Archive Nobel ...

  9. Gerhard Ertl, Nobel Laureate for Chemistry 2007

    NASA Astrophysics Data System (ADS)

    Kawai, Maki

    In year 2007, Nobel prize for Chemistry was awarded to Prof. Gerhard Ertl, former director of Fritz Haber Institute, Berlin. The article is to introduce the brilliant achievement of Prof. Ertl in part.

  10. DOE Research and Development Accomplishments Fielded Search

    Science.gov Websites

    Physicists Nobel Chemists Medicine Nobels Explore dropdown arrow Insights Blog Archive SC Stories Snapshots R /Issue Date Ascending Descending All Fields Bibliographic Data Title Author(s) Number Submit Clear Some

  11. 33 CFR 165.158 - Safety Zone: Patchogue Grand Prix, Patchogue Bay, Patchogue, NY.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... American Datum 1983. (b) Definitions. The following definitions apply to this section: Designated on-scene... zone on VHF-16 or via phone at (203) 468-4401. (d) Enforcement period. This rule will be enforced from...

  12. 33 CFR 165.158 - Safety Zone: Patchogue Grand Prix, Patchogue Bay, Patchogue, NY.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... American Datum 1983. (b) Definitions. The following definitions apply to this section: Designated on-scene... zone on VHF-16 or via phone at (203) 468-4401. (d) Enforcement period. This rule will be enforced from...

  13. 76 FR 29642 - Special Local Regulations; Miami Super Boat Grand Prix, Miami Beach, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ... INFORMATION CONTACT: If you have questions on this rule, call or e-mail Lieutenant Paul A. Steiner, Sector Miami Prevention Department, Coast Guard; telephone 305-535-8724, e-mail Paul.A.Steiner@uscg.mil . If...

  14. Perspectives on the 2010 Nobel Prize in physics for graphene.

    PubMed

    Dresselhaus, Mildred S; Araujo, Paulo T

    2010-11-23

    The 2010 Nobel Prize in physics was awarded to Andre Geim and Konstantin Novoselov for their groundbreaking experiments regarding the two-dimensional material graphene. Some personal perspectives about this award are presented.

  15. Heike Kamerlingh Onnes and the Nobel Prize in Physics for 1913: The Highest Honor for the Lowest Temperatures

    NASA Astrophysics Data System (ADS)

    Reif-Acherman, Simón

    2013-12-01

    One century ago this year the Dutch experimental physicist Heike Kamerlingh Onnes (1853-1926) was awarded the Nobel Prize in Physics for his work in low-temperature physics, in particular for his production of liquid helium. I trace the route to his Nobel Prize within the context of his and his colleagues' research in his laboratory at the University of Leiden, and in light of his nominators and the nominations he received in the five years 1909-1913.

  16. Effect of implant angulation and impression technique on impressions of NobelActive implants.

    PubMed

    Alexander Hazboun, Gillian Brewer; Masri, Radi; Romberg, Elaine; Kempler, Joanna; Driscoll, Carl F

    2015-05-01

    How the configuration of the NobelActive internal conical connection affects implant impressions is uncertain. The purpose of this study was to measure the effect in vitro of closed and open tray impression techniques for NobelActive implants placed at various angulations. Six NobelActive implants were placed in a master maxillary cast as follows: 0 degrees of angulation to a line drawn perpendicular to the occlusal plane in the first molar area, 15 degrees of angulation to a line drawn perpendicular to the occlusal plane in the first premolar area, and 30 degrees of angulation to a line drawn perpendicular to the occlusal plane in the lateral incisor area. Twelve open tray and 12 closed tray impressions were made. Occlusal, lateral, and frontal view photographs of the resulting casts were used to measure the linear and angular displacement of implant analogs. Statistical analysis was performed with a factorial analysis of variance (ANOVA), followed by the Tukey HSD test (α=.05). No significant difference was found in the impressions made of NobelActive implants with the open or closed tray technique (linear displacement: F=0.93, P=.34; angular displacement: F=2.09, P=.15). In addition, implant angulation (0, 15, or 30 degrees) had no effect on the linear or angular displacement of impressions (linear displacement: F=2.72, P=.07; angular displacement: F=0.86, P=.43). Finally, no significant interaction was found between impression technique and implant angulation on NobelActive implants (F=0.25, P=.77; F=1.60, P=.20). Within the limitations of this study, impression technique (open vs closed tray) and implant angulation (0, 15, and 30 degrees) had no significant effect on in vitro impressions of NobelActive implants. Copyright © 2015 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  17. The laureate as celebrity genius: How Scientific American's John Horgan profiled Nobel Prize winners.

    PubMed

    Fahy, Declan

    2018-05-01

    When scientists become Nobel laureates, they become famous in science and public life, but few studies have examined the nature of their scientific celebrity. This article examines how Scientific American portrayed laureates in order to identify and explain core features of Nobel fame. It examines the portrayals of seven laureates - Francis Crick, Linus Pauling, Hans Bethe, Murray Gell-Mann, Brian Josephson, Philip Anderson and Subrahmanyan Chandrasekhar - in magazine profiles written between 1992 and 1995 by science writer John Horgan. Its textual analysis finds the scientists are portrayed as combining the sociological characteristics of genius, including enormous productivity and lasting impact, with the representational characteristics of celebrities, such as the merging of public and private lives. Their form of scientific celebrity is grounded in their field-changing research, which is presented as a product of their idiosyncratic personalities. Nobel science is presented as knowledge created by an ultra-elite of exceptional individuals.

  18. The character of scientists in the Nobel Prize speeches.

    PubMed

    Condit, Celeste M

    2018-05-01

    This essay describes the ethos (i.e. the character projected to specific audiences) of the 25 Nobel Lectures in Physics, Chemistry, and Physiology or Medicine given in 2013-2015 and the 15 Presentation Speeches given at the Nobel Banquets between 2011 and 2015. A thematically focused qualitative analysis grounded in theories of epideictic discourse indicates the Nobel speakers demonstrated a range of strategies for and degrees of success in negotiating the tensions created by the implicit demands of ceremonial speeches, the scientific emphasis on didactic style and research content, and the different potential audiences (scientific experts and interested publics). Relatively few speeches explicitly displayed goodwill toward humanity instead of primarily toward the scientific community. Some speakers emphasized qualities of goodness in line with social values shared by broad audiences, but some reinforced stereotypes of scientists as anti-social. Speakers were variable in their ability to bridge the substantial gaps in resources for shared good sense.

  19. Scientometric identification of elite 'revolutionary science' research institutions by analysis of trends in Nobel prizes 1947-2006.

    PubMed

    Charlton, Bruce G

    2007-01-01

    Most research is 'normal science' using Thomas Kuhn's term: checking, trial-and-error improvement and incremental extrapolation of already existing paradigms. By contrast, 'revolutionary science' changes the fundamental structures of science by making new theories, discoveries or technologies. Science Nobel prizes (in Physics, Chemistry, Physiology/Medicine and Economics) have the potential to be used as a new metric for measuring revolutionary science. Nobel laureates' nations and research institutions were measured between 1947 and 2006 in 20 year segments. The minimum threshold for inclusion was 3 Nobel prizes. Credit was allocated to each laureate's institution and nation of residence at the time of award. Over 60 years, the USA has 19 institutions which won three-plus Nobel prizes in 20 years, the UK has 4, France has 2 and Sweden and USSR 1 each. Four US institutions won 3 or more prizes in all 20 year segments: Harvard, Stanford, Berkeley and CalTech. The most successful institution in the past 20 years was MIT, with 11 prizes followed by Stanford (9), Columbia and Chicago (7). But the Western United States has recently become the world dominant region for revolutionary science, generating a new generation of elite public universities: University of Colorado at Boulder; University of Washington at Seattle; and the University of California institutions of Santa Barbara, Irvine, UCSF, and UCLA; also the Fred Hutchinson CRC in Seattle. Since 1986 the USA has 16 institutions which have won 3 plus prizes, but elsewhere in the world only the College de France has achieved this. In the UK Cambridge University, Cambridge MRC unit, Oxford and Imperial College have declined from 17 prizes in 1967-86 to only 3 since then. Harvard has also declined as a revolutionary science university from being the top Nobel-prize-winning institution for 40 years, to currently joint sixth position. Although Nobel science prizes are sporadically won by numerous nations and institutions, it seems that long term national strength in revolutionary science is mainly a result of sustaining and newly-generating multi-Nobel-winning research centres. At present these elite institutions are found almost exclusively in the USA. The USA is apparently the only nation with a research system that nurtures revolutionary science on a large scale.

  20. LED firm rejects Nobel laureate's olive branch

    NASA Astrophysics Data System (ADS)

    Banks, Michael

    2014-12-01

    Nobel laureate Shuji Nakamura says that he is not going to try and improve relations with his former employer, which he sued in 2001 over his development of the blue light-emitting diode (LED), after receiving a snub from them last month.

  1. Ames Lab 101: Danny Shechtman Returns to the Ames Laboratory

    ScienceCinema

    Shechtman, Danny

    2018-05-07

    Danny Shechtman, Ames Laboratory Scientist and winner of the Nobel Prize in Chemistry 2011, returned to the Ames Lab on February 14, 2012. During this time, the Nobel Laureate met with the press as well as ISU students.

  2. Nobel Lecture: Topological quantum matter*

    NASA Astrophysics Data System (ADS)

    Haldane, F. Duncan M.

    2017-10-01

    Nobel Lecture, presented December 8, 2016, Aula Magna, Stockholm University. I will describe the history and background of three discoveries cited in this Nobel Prize: The "TKNN" topological formula for the integer quantum Hall effect found by David Thouless and collaborators, the Chern insulator or quantum anomalous Hall effect, and its role in the later discovery of time-reversal-invariant topological insulators, and the unexpected topological spin-liquid state of the spin-1 quantum antiferromagnetic chain, which provided an initial example of topological quantum matter. I will summarize how these early beginnings have led to the exciting, and currently extremely active, field of "topological matter."

  3. Fame or footnote?

    NASA Astrophysics Data System (ADS)

    2008-08-01

    The award of a Nobel prize can leave some deserving researchers empty-handed In 1968 the late sociologist Robert Merton published a study in the journal Science in which he addressed how various "psychosocial" factors can affect the attribution of merit in science (159 56). Drawing on insights provided by interviews with Nobel laureates, Merton realized that, contrary to popular perception, good things do not always come to those who scream Eureka!. "They [Nobel-prize winners] repeatedly observe that eminent scientists get disproportionately great credit for their contributions to science," he wrote, "while relatively unknown scientists tend to get disproportionately little credit for comparable contributions".

  4. The Black-Scholes option pricing problem in mathematical finance: generalization and extensions for a large class of stochastic processes

    NASA Astrophysics Data System (ADS)

    Bouchaud, Jean-Philippe; Sornette, Didier

    1994-06-01

    The ability to price risks and devise optimal investment strategies in thé présence of an uncertain "random" market is thé cornerstone of modern finance theory. We first consider thé simplest such problem of a so-called "European call option" initially solved by Black and Scholes using Ito stochastic calculus for markets modelled by a log-Brownien stochastic process. A simple and powerful formalism is presented which allows us to generalize thé analysis to a large class of stochastic processes, such as ARCH, jump or Lévy processes. We also address thé case of correlated Gaussian processes, which is shown to be a good description of three différent market indices (MATIF, CAC40, FTSE100). Our main result is thé introduction of thé concept of an optimal strategy in the sense of (functional) minimization of the risk with respect to the portfolio. If the risk may be made to vanish for particular continuous uncorrelated 'quasiGaussian' stochastic processes (including Black and Scholes model), this is no longer the case for more general stochastic processes. The value of the residual risk is obtained and suggests the concept of risk-corrected option prices. In the presence of very large deviations such as in Lévy processes, new criteria for rational fixing of the option prices are discussed. We also apply our method to other types of options, `Asian', `American', and discuss new possibilities (`doubledecker'...). The inclusion of transaction costs leads to the appearance of a natural characteristic trading time scale. L'aptitude à quantifier le coût du risque et à définir une stratégie optimale de gestion de portefeuille dans un marché aléatoire constitue la base de la théorie moderne de la finance. Nous considérons d'abord le problème le plus simple de ce type, à savoir celui de l'option d'achat `européenne', qui a été résolu par Black et Scholes à l'aide du calcul stochastique d'Ito appliqué aux marchés modélisés par un processus Log-Brownien. Nous présentons un formalisme simple et puissant qui permet de généraliser l'analyse à une grande classe de processus stochastiques, tels que les processus ARCH, de Lévy et ceux à sauts. Nous étudions également le cas des processus Gaussiens corrélés, dont nous montrons qu'ils donnent une bonne description de trois indices boursiers (MATIF, CAC40, FTSE100). Notre résultat principal consiste en l'introduction du concept de stratégie optimale dans le sens d'une minimisation (fonctionnelle) du risque en fonction du portefeuille d'actions. Si le risque peut être annulé pour les processus `quasi-Gaussien' non-corrélés, dont le modèle de Black et Scholes est un exemple, cela n'est plus vrai dans le cas général, le risque résiduel permettant de proposer des coûts d'options "corrigés". En présence de très grandes fluctuations du marché telles que décrites par les processus de Lévy, de nouveaux critères pour fixer rationnellement le prix des options sont nécessaires et sont discutés. Nous appliquons notre méthode à d'autres types d'options, telles que `asiatiques', `américaines', et à de nouvelles options que nous introduisons comme les `options à deux étages'... L'inclusion des frais de transaction dans le formalisme conduit à l'introduction naturelle d'un temps caractéristique de transaction.

  5. Nobel physics laureate migration

    NASA Astrophysics Data System (ADS)

    Johnston, Hamish

    2015-11-01

    The movement of talented researchers across international borders has been the lifeblood of physics for more than a century. In these infographics, Hamish Johnston delves into the archives to discover which countries have gained the most physics Nobel laureates, and which have suffered the worst brain drains.

  6. Hazardous Waste Cleanup: Akzo Nobel Polymer Chemicals, LLC, Burt, New York

    EPA Pesticide Factsheets

    Akzo Nobel Polymer Chemicals, LLC is located in northern Niagara County, south of Lake Ontario. The facility encompasses 350 acres, of which 30 acres are used for the production of organic peroxides. Eighteen Mile Creek is located immediately west of the

  7. PILOT-SCALE INCINERATION OF CONTAMINATED SLUDGES FROM THE BOFORS-NOBEL SUPERFUND SITE

    EPA Science Inventory

    A detailed test program was performed at the U.S. Environmental Protection Agency’s (EPA’s) Incineration Research Facility (IRF) to help determine the effectiveness of incineration in treating two contaminated lagoon sludges from the Bofors-Nobel Superfund site in Mus...

  8. 75 FR 770 - Acrylic acid-benzyl methacrylate-1-propanesulfonic acid, 2-methyl-2-[(1-oxo-2-propenyl)amino...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-06

    ....960. Akzo Nobel Surface Chemistry LLC submitted a petition to EPA under the Federal Food, Drug, and... the receipt of a pesticide petition (PP 9E7599) filed by Akzo Nobel Surface Chemistry LLC. The...

  9. Reflections on the Nobel Prize for Medicine 2015--The Public Health Legacy and Impact of Avermectin and Artemisinin.

    PubMed

    Molyneux, David H; Ward, Steve A

    2015-12-01

    The award of the Nobel Prize to Dr Bill Campbell and Professor Satoshi Ōmura for their role in the discovery of avermectin and Professor Youyou Tu for her work on the development of artemisinin has been universally welcomed by the International Health community for what the Nobel Committee described as 'The discoveries of Avermectin and Artemisinin have revolutionized therapy for patients suffering from devastating parasitic diseases. Campbell, Ōmura and Tu have transformed the treatment of parasitic diseases. The global impact of their discoveries and the resulting benefit to mankind are immeasurable'. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. The History of Cortisone Discovery and Development.

    PubMed

    Burns, Christopher M

    2016-02-01

    Philip Hench, Edward Kendall, and Tadeus Reichstein received the Nobel Prize in medicine and physiology in 1950 for their "investigations of the hormones of the adrenal cortex." Hench and Kendall took compound E from the laboratory to the clinic to the Nobel Prize in a span of 2 years. This article examines the paths that led to the day when the first rheumatoid arthritis patient received cortisone, and from there to the 1950 Nobel Prize ceremony. The aftermath of this achievement is also discussed. Although there have been significant advances in corticosteroid preparations and use since 1950, the side effects remain daunting. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. X-ray Studies Key to Nobel Prize Winning Work on Protein Receptors

    ScienceCinema

    Janet Smith; Robert Fischetti

    2018-05-08

    It was the advent of the first micro X-ray beam for structural biology at the Advanced Photon Source at Argonne National Laboratory that enabled the research that earned the 2012 Nobel Prize in Chemistry and lays the groundwork for countless new pharmaceuticals.

  12. X-ray Studies Key to Nobel Prize Winning Work on Protein Receptors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Janet Smith; Robert Fischetti

    2013-02-04

    It was the advent of the first micro X-ray beam for structural biology at the Advanced Photon Source at Argonne National Laboratory that enabled the research that earned the 2012 Nobel Prize in Chemistry and lays the groundwork for countless new pharmaceuticals.

  13. Using the Nobel Laureates in Economics to Teach Quantitative Methods

    ERIC Educational Resources Information Center

    Becker, William E.; Greene, William H.

    2005-01-01

    The authors show how the work of Nobel Laureates in economics can enhance student understanding and bring them up to date on topics such as probability, uncertainty and decision theory, hypothesis testing, regression to the mean, instrumental variable techniques, discrete choice modeling, and time-series analysis. (Contains 2 notes.)

  14. PEOPLE IN PHYSICS: Nobel prize winners in physics from 1901 to 1990: simple statistics for physics teachers

    NASA Astrophysics Data System (ADS)

    Zhang, Weijia; Fuller, Robert G.

    1998-05-01

    A demographic database for the 139 Nobel prize winners in physics from 1901 to 1990 has been created from a variety of sources. The results of our statistical study are discussed in the light of the implications for physics teaching.

  15. Recognizing the Achievements of Women in Science.

    ERIC Educational Resources Information Center

    Dujari, Anuradha

    2000-01-01

    Lists the women Nobel Prize laureates and questions why, with the exception of Marie Curie, all these women scientists are not well known by the public. Explains why so few women have won the Nobel Prize in science and medicine as compared to other fields. (Contains 18 references.) (YDS)

  16. Hazardous Waste Cleanup: Dyno Nobel Incorporated in Ulster Park, New York

    EPA Pesticide Factsheets

    Dyno Nobel is located on Ulster Avenue in Ulster Park, approximately one mile south of the village of Port Ewen in Ulster County, New York, in a small valley bordered by Hussey Hill on the west and a low lying ridge (adjacent to the Hudson River) to the

  17. Smoot Cosmology Group

    Science.gov Websites

    annually at Nasa Ames Research Center, in the heart of Silicon Valley, for 10 weeks of discussions on how _____________________________________________________________________________________ Hawking, NASA Head, Nobel Winners Visit The African Institute for Mathematical Sciences (AIMS) AIMS Stephen Hawking, the NASA Administrator Michael Griffin, and the winners of the 2004 and 2006 Nobel Prizes

  18. The Competition "First Step to Nobel Prize in Physics"

    ERIC Educational Resources Information Center

    Gorzkowski, W.; Surya, Y; Zuberek, R

    2011-01-01

    This paper presents the history of the competition First Step to Nobel Prize in Physics organized by Poland, its development from a national workshop in 1991/92 to an international competition nowadays and its organization, as well as the results obtained by the participants. (Contains 1 table.)

  19. 78 FR 42804 - SST Truck Company, LLC, a Navistar, Inc. Company Including On-Site Leased Workers From Employee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ... Contract Services, Encore, International Business Machines (IBM), Akzo Nobel, US Security, ASF Logistics... Services, Encore, International Business Machines (IBM), Akzo Nobel, US Security, ASF Logistics, LLC... class 4-8 trucks. The company reports that workers leased from Encore, International Business Machines...

  20. Owen Chamberlain - Patents

    Science.gov Websites

    Physicists Nobel Chemists Medicine Nobels Explore dropdown arrow Insights Blog Archive SC Stories Snapshots R * Resources with Additional Information US 2,521,656 IONIZATION CHAMBER - Segre, E. G.; Chamberlain, O COINCIDENCE CIRCUIT - Chamberlain, O.; Wiegand, C. E.; April 22, 1952 (to the U.S. Atomic Energy Commission

  1. FORTRAN Based Linear Programming for Microcomputers.

    DTIC Science & Technology

    1982-12-01

    OB.JECTIVE FUNCTION I C COEFFICIENTS AND MAXINIZATIONiIINIZATION CHOICE OF THE I c CURRENT NOBEL . USED IN CORRECTION OF MOST RECENi NOEL INPUT I C OP...WRITE (1, 200) 200 FeRNAT/5WINyALID ENTRY, PLEASE REENTER’) 60 TO 150 ENDIF C NOBEL WRTTEN TO DISK WAItE (3) PN, NXNN,NN,K1 , NE-C, N6C,NLC DO 250 121,10...CHAR4I2) WRITE’A,’Ql1’/,1X,’’INSCRE DISK( LPI1 5I AVAIL43LE.’’,7(/)’f PAUSE C NME OF NOBEL LAST SAVED WRITTEN TO TR.ANSFER FILE OFEN(3,FILEx’LPIsLPDATA

  2. 78 FR 22811 - Special Local Regulations; Mayaguez Grand Prix, Mayaguez Bay; Mayaguez, PR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ..., a high speed boat race. The event is scheduled to take place on Sunday, June 9, 2013. Approximately 30 high- speed power boats will be participating in the races. The special local regulation is... area, where all persons and vessels, except those persons and vessels participating in the high-speed...

  3. Thomas R. Cech, RNA, and Ribozymes

    Science.gov Websites

    RSS Archive Videos XML DOE R&D Accomplishments DOE R&D Accomplishments searchQuery × Find searchQuery x Find DOE R&D Acccomplishments Navigation dropdown arrow The Basics dropdown arrow Home About Physicists Nobel Chemists Medicine Nobels Explore dropdown arrow Insights Blog Archive SC Stories Snapshots R

  4. The Nobel Prize in Medicine for Magnetic Resonance Imaging

    ERIC Educational Resources Information Center

    Fry, Charles G.

    2004-01-01

    Nobel Prize in Medicine awarded in December 2003 to chemist Paul C. Lauterbur and physicist Peter Mansfield for the development of magnetic resonance imaging (MRI), a long overdue recognition of the huge impact MRI has had in medical diagnostics and research is mentioned. MRI was derived, and remains an extension of nuclear magnetic resonance…

  5. Modular Curriculum: English, American Nobel Prize Winners in Literature.

    ERIC Educational Resources Information Center

    Phillips, James A.

    This independent study module treats those Americans who have been awarded the Nobel Prize in Literature. They include Sinclair Lewis, Eugene O'Neill, T. S. Eliot, William Faulkner, Ernest Hemingway, John Steinbeck, and Pearl Buck. Selections from the writings of these authors are included. Their works represent many literary genres and also…

  6. The Design of Curriculum Development Based on Entrepreneurship through Balanced Scorecard Approach

    ERIC Educational Resources Information Center

    Hidayat, Muhammad; Musa, Chalid Imran; Haerani, Siti; Sudirman, Indrianti

    2015-01-01

    This research is intended to develop curriculum based on entrepreneurship through balanced scorecard approach at the School of Business or "Sekolah Tinggi Ilmu Ekonomi" (STIE) Nobel Indonesia. In order to develop the curriculum, a need analysis in terms of curriculum development that involves all stakeholders at STIE Nobel in Indonesia…

  7. Alfred Nobel and His Prizes: From Dynamite to DNA.

    PubMed

    Lichtman, Marshall A

    2017-07-01

    Alfred Nobel was one of the most successful chemists, inventors, entrepreneurs, and businessmen of the late nineteenth century. In a decision later in life, he rewrote his will to leave virtually all his fortune to establish prizes for persons of any nationality who made the most compelling achievement for the benefit of mankind in the fields of chemistry, physics, physiology or medicine, literature, and peace among nations. The prizes were first awarded in 1901, five years after his death. In considering his choice of prizes, it may be pertinent that he used the principles of chemistry and physics in his inventions and he had a lifelong devotion to science, he suffered and died from severe coronary and cerebral atherosclerosis, and he was a bibliophile, an author, and mingled with the literati of Paris. His interest in harmony among nations may have derived from the effects of the applications of his inventions in warfare ("merchant of death") and his friendship with a leader in the movement to bring peace to nations of Europe. After some controversy, including Nobel's citizenship, the mechanisms to choose the laureates and make four of the awards were developed by a foundation established in Stockholm; the choice of the laureate for promoting harmony among nations was assigned to the Norwegian Storting, another controversy. The Nobel Prizes after 115 years remain the most prestigious of awards. This review describes the man, his foundation, and the prizes with a special commentary on the Nobel Prize in Physiology or Medicine.

  8. Erosive potential of vitamin and vitamin+mineral effervescent tablets.

    PubMed

    Wegehaupt, Florian J; Lunghi, Nancy; Hogger, Vanessa M G; Attin, Thomas

    2016-01-01

    The extrinsic sources for erosion-causing acids are primarily acidic beverages and foodstuffs. Effervescent tablets also contain organic acids (e.g. citric, tartaric, malic) in order to form carbon dioxide by contact with water – with the help of the carbonate salts of the tablets. To adequately inform patients about the possible erosive potential of effervescent tablets, this study was undertaken in order to investigate the erosive potential of effervescent tablets (ET), containing either a combination of vitamins and minerals or vitamins only, commercially available in Switzerland. One hundred and ninety-two bovine enamel samples were prepared and allocated to 16 groups (A–H and 1–8; n = 12/group). Samples were eroded (120 s/erosive cycle) in freshly prepared solutions (200 ml/12 samples) comprised of tap water and a supplement as follows: none (control groups, A and 1); vitamin+mineral ET: Qualite and Prix (B), Optisana (C), Well and Active (D), Actilife All in One (E), Berocca (F), Isostar (G) and Qualite and Prix Mg + Vit C (H); vitamin ET: Actilife-Multivitamin (2), Sunlife Vitamin C (3), Optisana Vitamin C (4), Optisana Multivitamin (5), Well and Active Multivitamin (6), Kneipp Vitamin C+Zink (7) and Sunlife Multivitamin (8). Enamel loss was measured using profilometry after 10 and 20 erosive cycles. For the vitamin+mineral ET, no loss was observed in groups B–E. Significantly highest enamel loss (mean ± SD) after 20 cycles was observed for Isostar (5.26 ± 0.76 µm) and Qualite and Prix Mg + Vit C (5.12 ± 0.67 µm). All vitamine ET showed erosive enamel loss. Significantly highest loss was observed for Sunlife Multivitamin (8.45 ± 1.08 µm), while the lowest loss was observed for Actilife-Multivitamin (5.61 ± 1.08 µm) after 20 cycles. Some of the tested effervescent tablets showed a considerable erosive potential and patients should be informed accordingly.

  9. DOE Research and Development Accomplishments: Visions of Success I

    Science.gov Websites

    RSS Archive Videos XML DOE R&D Accomplishments DOE R&D Accomplishments searchQuery × Find searchQuery x Find DOE R&D Acccomplishments Navigation dropdown arrow The Basics dropdown arrow Home About Physicists Nobel Chemists Medicine Nobels Explore dropdown arrow Insights Blog Archive SC Stories Snapshots R

  10. DOE Research and Development Accomplishments Contact Us

    Science.gov Websites

    RSS Archive Videos XML DOE R&D Accomplishments DOE R&D Accomplishments searchQuery × Find searchQuery x Find DOE R&D Acccomplishments Navigation dropdown arrow The Basics dropdown arrow Home About Physicists Nobel Chemists Medicine Nobels Explore dropdown arrow Insights Blog Archive SC Stories Snapshots R

  11. DOE Research and Development Accomplishments QR Code

    Science.gov Websites

    RSS Archive Videos XML DOE R&D Accomplishments DOE R&D Accomplishments searchQuery × Find searchQuery x Find DOE R&D Acccomplishments Navigation dropdown arrow The Basics dropdown arrow Home About Physicists Nobel Chemists Medicine Nobels Explore dropdown arrow Insights Blog Archive SC Stories Snapshots R

  12. DOE Research and Development Accomplishments What's New

    Science.gov Websites

    RSS Archive Videos XML DOE R&D Accomplishments DOE R&D Accomplishments searchQuery × Find searchQuery x Find DOE R&D Acccomplishments Navigation dropdown arrow The Basics dropdown arrow Home About Physicists Nobel Chemists Medicine Nobels Explore dropdown arrow Insights Blog Archive SC Stories Snapshots R

  13. DOE Research and Development Accomplishments: Fast Facts

    Science.gov Websites

    RSS Archive Videos XML DOE R&D Accomplishments DOE R&D Accomplishments searchQuery × Find searchQuery x Find DOE R&D Acccomplishments Navigation dropdown arrow The Basics dropdown arrow Home About Physicists Nobel Chemists Medicine Nobels Explore dropdown arrow Insights Blog Archive SC Stories Snapshots R

  14. Nobel Prize Honors Autophagy Discovery.

    PubMed

    2016-12-01

    Japanese cell biologist Yoshinori Ohsumi, PhD, was awarded this year's Nobel Prize in Physiology or Medicine for his discovery of autophagy. His groundbreaking studies in yeast cells illuminated how cells break down and recycle damaged material, a process that is critical to the survival of both normal cells and some cancer cells. ©2016 American Association for Cancer Research.

  15. Nobel Laureate Mohamed ElBaradei: Preventing Nuclear Proliferation Peacefully

    ERIC Educational Resources Information Center

    Dufour, Joanne

    2006-01-01

    The 2005 Nobel Peace Prize was awarded 60 years after the first atomic bombs fell on the Japanese cities of Hiroshima and Nagasaki, killing more than 200,000 people; the peace prize raises the hopes of those working to rejuvenate global efforts to prevent the spread and development of nuclear arms. This article profiles the International Atomic…

  16. DOE-Supported Physicists are Co-Winners of 2004 Nobel Prize in Physics

    Science.gov Websites

    in Physics WASHINGTON, DC -- "On behalf of the U.S. Department of Energy, I congratulate Frank Wilczek, H. David Politzer and David J. Gross for winning the 2004 Nobel Prize in Physics," said agencies, have been the leading Federal supporter of research in physics, enabling vital advances and

  17. Eppur Si Muove! The 2013 Nobel Prize in Chemistry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, Jeremy C.; Roux, Benoit

    2013-12-03

    The 2013 Nobel Prize in Chemistry has been awarded to Martin Karplus, Michael Levitt, and Arieh Warshel for their work on developing computational methods to study complex chemical systems. Hence, their work has led to mechanistic critical insights into chemical systems both large and small and has enabled progress in a number of different fields, including structural biology.

  18. How Robert A. Millikan Got the Physics Nobel Prize

    ERIC Educational Resources Information Center

    Panusch, Martin; Heering, Peter; Singh, Rajinder

    2010-01-01

    In 1923, R.A. Millikan was awarded the Nobel Prize in Physics for his work on the elementary charge of electricity and on the photoelectric effect. Recently, historical research had a focus on Millikan's publication practice, as well as on the role of his assistant, Harvey Fletcher. Several studies have raised doubts on whether Millikan can…

  19. Does Cometary Panspermia Falsify Dark Energy?

    NASA Astrophysics Data System (ADS)

    Gibson, Carl H.

    2011-10-01

    The 2011 Nobel Prize for physics has been awarded to Saul Perlmutter, Brian P. Schmidt, and Adam G. Riess "for the discovery of the accelerating expansion of the Universe through observations of distant supernovae", judged to be the "most important discovery or invention within the field of physics" (Excerpt from the will of Alfred Nobel). Are we forced by this claimed discovery to believe the universe is dominated by anti- gravitational dark energy? Can the discovery be falsified? Because life as we observe it on Earth is virtually impossible by the standard ΛCDMHC model, extraterrestrial life and cometary panspermia may provide the first definitive falsification of a Nobel Prize in Physics since its first award in 1901 to Wilhelm Röntgen for his discovery of X-rays.

  20. [The 69th Congress-urologists nominated for the Nobel Prize : Not everyone got a prize: four biographical sketches].

    PubMed

    Moll, F H; Halling, T; Krischel, M; Hansson, N; Fangerau, H

    2017-09-01

    Our research group has reconstructed why the board certified urologists Werner Forssmann (1904-1979) and Charles Huggins (1901-1997) received the Nobel Prize in physiology or medicine (1956, and 1966, respectively). But the history of "Urology and the Nobel Prize" is in fact more multifaceted than the success stories of these two laureates suggest. James Israel (1848-1926), Berlin, Félix Guyon (1831-1920), Paris, Peter J. Freyer (1852-1921), London and Edwin Beer (1876-1938), New York were nominated for the award during the first three decades of the 20th century. Their candidacies mirror trends among leading urologists during the time when urology became a specialty in its own right.

  1. From the Big Bang to the Nobel Prize and the JWST

    NASA Technical Reports Server (NTRS)

    Mather, John C.

    2007-01-01

    I will describe the history of the universe, from the Big Bang to 2013, when the JWST is to be launched to look back towards our beginnings. I will discuss how the COBE results led to the Nobel Prize, how the COBE results have been confirmed and extended, and their implications for future observations. The James Webb Space Telescope will be used to examine every part of our history from the first stars and galaxies to the formation of individual stars and planets and the delivery of life-supporting materials to the Earth. I will describe the plans for the JWST and how observers may use it. With luck, the JWST may produce a Nobel Prize for some discovery we can only guess today.

  2. Media Literacy, Congratulations! Now, the Next Step

    ERIC Educational Resources Information Center

    Torrent, Jordi

    2011-01-01

    Media Literacy Education has definitely come a long way. The author remembers mentioning Media Literacy at a Prix Jeunesse presentation in New York City in the early-mid 1990s-- all the participants looked at him as a weirdo and politely ignored his comment on the necessity for TV producers to include or at least reflect upon media…

  3. 78 FR 52231 - 2013 Temporary Closure of I-395 Just South of Conway Street in the City of Baltimore to Vehicular...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-22

    ... Accommodate the Construction and Operation of the Baltimore Grand Prix AGENCY: Federal Highway Administration..., September 3, 2013. The closure is requested to accommodate the construction and operation of the Baltimore... FURTHER INFORMATION CONTACT: Ms. Crystal Jones, Office of Freight Management and Operations, Office of...

  4. 76 FR 52380 - Temporary Closure of I-395 Just South of Conway Street in the City of Baltimore to Vehicular...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... the Construction and Operation of the Baltimore Grand Prix AGENCIES: Federal Highway Administration..., September 6, 2011. The closure is requested to accommodate the construction and operation of the Baltimore... most arriving by private vehicle. The construction and operation of the race course will create safety...

  5. 33 CFR 100.717 - Annual Fort Myers Beach Offshore Grand Prix; Fort Myers, FL.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...°58.30′ W). All coordinates referenced use datum: NAD 83. (b) Special local regulations. (1) No vessel... coordinates referenced use datum: NAD 83. (3) All vessel traffic, not involved with the Fort Myers Beach... clear of the racecourse. All coordinates referenced use datum: NAD 83. (4) All vessel traffic, not...

  6. Lunar Roving Vehicle gets speed workout by Astronaut John Young

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The Lunar Roving Vehicle (LRV) gets a speed workout by Astronaut John W. Young in the 'Grand Prix' run during the third Apollo 16 extravehicular activity (EVA-3) at the Descartes landing site. This view is a frame from motion picture film exposed by a 16mm Maurer camera held by Astronaut Charels M. Duke Jr.

  7. 78 FR 34568 - Special Local Regulation; Heritage Coast Offshore Grand Prix, Tawas Bay; East Tawas, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... of any grant or loan recipients, and will not raise any novel legal or policy issues. The Coast Guard... special local regulation. 2. Impact on Small Entities The Regulatory Flexibility Act of 1980 (RFA), 5 U.S... small entities during rulemaking. The term ``small entities'' comprises small businesses, not-for-profit...

  8. 33 CFR 100.717 - Annual Fort Myers Beach Offshore Grand Prix; Fort Myers, FL.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...°58.30′ W). All coordinates referenced use datum: NAD 83. (b) Special local regulations. (1) No vessel... coordinates referenced use datum: NAD 83. (3) All vessel traffic, not involved with the Fort Myers Beach... clear of the racecourse. All coordinates referenced use datum: NAD 83. (4) All vessel traffic, not...

  9. 33 CFR 100.717 - Annual Fort Myers Beach Offshore Grand Prix; Fort Myers, FL.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...°58.30′ W). All coordinates referenced use datum: NAD 83. (b) Special local regulations. (1) No vessel... coordinates referenced use datum: NAD 83. (3) All vessel traffic, not involved with the Fort Myers Beach... clear of the racecourse. All coordinates referenced use datum: NAD 83. (4) All vessel traffic, not...

  10. 33 CFR 100.717 - Annual Fort Myers Beach Offshore Grand Prix; Fort Myers, FL.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...°58.30′ W). All coordinates referenced use datum: NAD 83. (b) Special local regulations. (1) No vessel... coordinates referenced use datum: NAD 83. (3) All vessel traffic, not involved with the Fort Myers Beach... clear of the racecourse. All coordinates referenced use datum: NAD 83. (4) All vessel traffic, not...

  11. 33 CFR 100.717 - Annual Fort Myers Beach Offshore Grand Prix; Fort Myers, FL.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...°58.30′ W). All coordinates referenced use datum: NAD 83. (b) Special local regulations. (1) No vessel... coordinates referenced use datum: NAD 83. (3) All vessel traffic, not involved with the Fort Myers Beach... clear of the racecourse. All coordinates referenced use datum: NAD 83. (4) All vessel traffic, not...

  12. [The Nobel Prize for nitric oxide. The unjust exclusion of Dr. Salvador Moncada].

    PubMed

    de Berrazueta, J R

    1999-04-01

    The 1998 Nobel Prize in Physiology and Medicine has been awarded jointly to North-American scientists, Dr Robert F. Furchgott, Louis J. Ignarro and Ferid Murad, for their discoveries in relation to "nitric oxide as a signalling molecule in the cardiovascular system". This has raised an important polemic because of the exclusion the South-American scientist, now nationalized British, Dr. Salvador Moncada. This short historical review examines some of the fundamental contributions to the knowledge in this field. It shows the sequence of the discoveries and the communication of them to the scientific community by the rewarded scientists and by Dr. Moncada. It is based on some fundamental publications in order to better understand this story, which does not coincide with the writing in 1996 by the Lasker Prize Committee, and which in 1998 was re-written again by the Nobel Committee of the Swedish Academy. More than 90 universities, academies and societies have acknowledged Dr. Moncada up to now with priority in the discovery of the fact that nitric oxide is released by endothelial cells, and the revealing of its metabolic way. More than 20,000 citations of their fundamental papers endorse in the scientific community his primacy in this field. Even Robert Furchgott, author of the brilliant discovery of the endothelium derived relaxing factor, that opened this field to the science, declared about the award of the 1998 Nobel Prize: "I feel that the Nobel Prize Committee could have made an exception this year and chosen a fourth person, Salvador Moncada (to share the prize)".

  13. Nobel Prize Recipient Eric Betzig Presents Lecture on Efforts to Improve High-Resolution Microscopy | Poster

    Cancer.gov

    Eric Betzig, Ph.D., a 2014 recipient of the Nobel Prize in Chemistry and a scientist at Janelia Research Campus (JRC), Howard Hughes Medical Institute, in Ashburn, Va., visited NCI at Frederick on Sept. 10 to present a Distinguished Scientist lecture and discuss the latest high-resolution microscopy techniques. Betzig co-invented photoactivation localization microscopy (PALM)

  14. Pat Thiel talks about attending the Nobel Prize Award Ceremony

    ScienceCinema

    Thiel, Pat

    2018-05-07

    Pat Thiel, Ames Laboratory senior scientist and Iowa State University Distinguished Professor of Chemistry, was invited to be a guest at the ceremony on December 10th, in Stockholm, Sweden, where Danny Shechtman, Ames Laboratory scientist, received the 2011 Nobel Prize in Chemistry. Following her return to the Lab, Thiel shared some of her recollections of the momentous event.

  15. An Elusive Honor: Psychology, Behavior, and the Nobel Prize

    ERIC Educational Resources Information Center

    Pickren, Wade E.

    2003-01-01

    Apart from economics, the human sciences have not generally been rewarded with high honors from the world community. Psychology has been awarded the distinction of a Nobel Prize only when it has served a role in explicating human behavior in relation to economics. Yet psychological science has played no small part in the work of a number of Nobel…

  16. John Bardeen: The Only Person to Win Two Nobel Prizes in Physics

    ERIC Educational Resources Information Center

    Hoddeson, L.

    2011-01-01

    John Bardeen worked on the theory of solids throughout his physics career, winning two Nobel Prizes: the first in 1956 for the invention of the transistor with Walter Brattain and William Shockley; and the second in 1972 for the development with Leon Cooper and J Robert Schrieffer of the Bardeen-Cooper-Schrieffer (BCS) theory of superconductivity.…

  17. Pat Thiel talks about attending the Nobel Prize Award Ceremony

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thiel, Pat

    2012-01-01

    Pat Thiel, Ames Laboratory senior scientist and Iowa State University Distinguished Professor of Chemistry, was invited to be a guest at the ceremony on December 10th, in Stockholm, Sweden, where Danny Shechtman, Ames Laboratory scientist, received the 2011 Nobel Prize in Chemistry. Following her return to the Lab, Thiel shared some of her recollections of the momentous event.

  18. Communication; A Discussion at the Nobel Conference (5th, Gustavus Adolphus College, St. Peter, Minnesota, January 8-9, 1969).

    ERIC Educational Resources Information Center

    Roslansky, John D., Ed.

    This book consists of five lectures on communication given at the fifth Nobel Conference. Leroy G. Augenstein explores the positive and negative consequences of man's increasing capacity to manipulate and control the human mind. Peter Marler demonstrates that all the elements necessary for a communication system to qualify as a language exist…

  19. Climate Change Draws World Attention: The 2007 Nobel Peace Award Goes to Gore and IPCC

    ERIC Educational Resources Information Center

    Bisland, Beverly Milner; Ahmad, Iftikhar

    2008-01-01

    In the fall of 2007, the Nobel Committee awarded their Peace Prize to the Intergovernmental Panel on Climate Change (a scientific intergovernmental body set up by the World Meteorological Organization and by the United Nations Environment Program) and to former Vice-President Al Gore, Jr. The committee praised the United Nations panel for creating…

  20. Nobel Peace Laureate Muhammad Yunus: A Banker Who Believes Credit is a Human Right

    ERIC Educational Resources Information Center

    Szpara, Michelle Yvonne; Ahmad, Iftikhar; Pederson, Patricia Velde

    2007-01-01

    The article profiles Nobel Peace Laureate Muhammad Yunus, founder of Grameen Bank (an independent financial institution in Bangladesh), as well as an economics professor at the University of Chittagong. In his birthplace of Bangladesh, 49.8 percent of people exist below the poverty line, and 73.2 percent of the women are categorized as…

  1. Ralph Bunche's International Legacy: The Middle East, Congo, and United Nations Peacekeeping

    ERIC Educational Resources Information Center

    Lyman, Princeton N.

    2004-01-01

    Ralph Bunche is remembered most for three major achievements in the international field. His mediation of the end of the first Israel-Arab war, for which he won the Nobel Peace Prize; his work in the tumultuous period of independence in the Congo; and his "invention" of United Nations peacekeeping, which itself won the Nobel Peace Prize…

  2. Enhancing the public impact of the Higgs discovery and other fundamental physics research

    NASA Astrophysics Data System (ADS)

    Lidstrom, Suzy; Read, Alex; Parke, Stephen; Allen, Roland; Goldfarb, Steven; Mehlhase, Sascha; Ekelof, Tord; Walker, Alan

    2014-03-01

    The recent experimental discovery of a Higgs boson by the ATLAS and CMS collaborations at the LHC, together with the awarding of the 2013 Nobel Prize for its theoretical prediction, has presented an exceptional opportunity for public outreach regarding the goals and importance of fundamental research in physics. We discuss novel avenues for further extending this outreach in all areas. These range from tutorial papers addressing students and teachers to internet resources and presentations to unconventional, but captivating, educational materials such as musical videos and LEGO models. Interaction with active scientists can be particularly stimulating. We account how this was encouraged (by means such as badges inviting questions from the public) during Nobel week and afterwards. The 2013 Nobel Prize in Physics explained Physica Scripta, Royal Swedish Academy of Sciences.

  3. Préface

    NASA Astrophysics Data System (ADS)

    Paulus, Werner; Meinnel, Jean

    2003-02-01

    En 1994, l'attribution du prix Nobel à Cliff Shull et Bert Brockhouse pour leurs travaux de pionniers pendant les années 50, concernant tant la diffusion élastique des neutrons que la diffusion inélastique, a été la reconnaissance éclatante de l'importance de la diffusion neutronique pour toute la communauté scientifique.Le grand intérêt du neutron pour la recherche s'appuie principalement sur ses propriétés physiques particulières :- les neutrons utilisés pour la caractérisation de la matière (et fournis en relativement grandes quantités par les réacteurs ou les sources à spallation) disposent de longueurs d'onde et d'énergies correspondant directement aux distances interatomiques et aux énergies d'agitation de la matière. Ainsi, par diffusion neutronique, on peut étudier en même temps la structure et le comportement dynamique de la matière ;- le fait que le neutron soit doué d'un moment magnétique lui permet d'interagir avec tout atome porteur d'un moment magnétique. Ceci permet de caractériser intimement le comportement magnétique de la matière à l'échelle microscopique ;- la possibilité de pouvoir varier facilement le contraste d'un même élément en utilisant ses différents isotopes fait du neutron un outil irremplaçable en chimie et physique du solide ainsi qu'en biologie et matière molle ;- enfin, n'ayant pas de charge électrique, les neutrons peuvent pénétrer la matière sans être absorbés significativement, ce qui rend possible une caractérisation non destructive des contraintes et textures sur de grosses pièces des matériaux.Toutes les qualités des neutrons mentionnées ci-dessus permettent de comprendre l'importance de la diffusion neutronique pour des domaines très nombreux et très différents à la fois en recherche fondamentale mais aussi pour des applications industrielles. L'utilisation de l'outil-neutron demande toutefois non seulement une bonne connaissance des différents mécanismes d'interaction entre le neutron et la matière, mais également une haute spécificité dans la conception et l'utilisation des diffractomètres et spectromètres neutroniques. Pour ces raisons, l'accès aux neutrons est souvent limité, sinon réservé à des spécialistes, ce qui freine tout naturellement l'utilisation par des chercheurs non familiarisés à ce domaine.Pour combattre ce déficit d'information et cet état de fait, en accord avec de nombreux collègues Rennais, nous avons proposé à la Société Française de Neutronique d'organiser une École d'été qui s'adresse plus spécialement à de non-spécialistes de la diffusion neutronique. Le public visé concernait donc à la fois les chercheurs confirmés mais peu familiarisés avec le domaine neutronique, mais aussi les jeunes chercheurs dès le niveau doctorant. En effet pour ces derniers, l'utilisation des “grands instruments" s'avère nécessaire pour qu'ils soient à la hauteur de leur sujet de thèse. Pour cette raison, il était évident d'intégrer cette École d'été dans le programme de l'École Doctorale “Sciences des Matériaux" de l'Université de Rennes 1 qui rassemble chimistes, physiciens et géologues. Dans le même contexte, notre intérêt était de proposer un large spectre de cours couvrant la diversité des applications de la diffusion neutronique dans les différents domaines de recherche en chimie et physique des matériaux, en sciences de la terre ainsi qu'en sciences pour l'ingénieur. Un deuxième but était de montrer de plus la complémentarité des neutrons et des rayons X et plus spécifiquement des X produits par rayonnement synchrotron.Dans l'avenir, nous sommes persuadés que la diffusion neutronique va jouer un rôle clé pour le développement de nouveaux matériaux et de leur caractérisation. Dans cette optique, des efforts considérables ont été déjà engagés aux États-Unis ainsi qu'au Japon où deux nouvelles sources de neutrons sont en cours de construction. Du point de vue européen, si les sources de l'ILL et d'ISIS peuvent encore être considérées comme des leaders au point de vue mondial, il est évidemment souhaitable que la nouvelle source neutronique à spallation (European Spallation Source : ESS) soit rapidement réalisée. Aujourd'hui ce projet est bien avancé, cette source devrait dépasser le flux des sources actuelles par près de deux ordres de grandeur et ainsi de maintenir au meilleur niveau les compétences Européennes. Il est évident qu'une utilisation efficace et intelligente des sources existantes, mais aussi de celles de la nouvelle génération, implique une certaine infrastructure nationale tant au niveau de la conception, de la réalisation que du fonctionnement des différents spectromètres. Ceci implique un très fort engagement des universités dans les différents projets de recherche. Le devoir des universités qui en résulte est donc d'intégrer l'utilisation des “grands instruments" dans leur programme d'enseignement. Dans ce sens, nous souhaitons que ce cours, entièrement rédigé en français, contribue à la fois à aider les chercheurs “non spécialistes” à accéder plus facilement au domaine neutronique, mais aussi à servir de base aux enseignants pour l'organisation et la préparation de leurs cours.Nous tenons à remercier tous les collègues qui ont accepté de rédiger de façon détaillée les cours qu'ils avaient présentés oralement dans la grande salle du VVF de Trégastel, ainsi que toutes les personnes qui ont contribué à la réussite du séjour ou à la réalisation de ce fascicule. Nous gardons un excellent souvenir de l'atmosphère de l'École qui a eu lieu à Trégastel, en plein centre de la côte de granite rose en Bretagne, en mai 2001 et était jumelée avec les Journées de la diffusion neutronique, elles aussi organisées sous l'égide de la SFN.Nous souhaitons que la lecture de cet ouvrage soit utile à un maximum de chercheurs.

  4. In vitro fertilization, the Nobel Prize, and human embryonic stem cells.

    PubMed

    Gearhart, John; Coutifaris, Christos

    2011-01-07

    Robert Edwards was awarded the 2010 Nobel Prize in Physiology or Medicine for the development of human in vitro fertilization. His work not only provided the means to overcome many forms of infertility, but it also enabled research on early stages of human embryos and the derivation of human embryonic stem cells. Copyright © 2011 Elsevier Inc. All rights reserved.

  5. DOE Research and Development Accomplishments Alfred Nobel Laureates

    Science.gov Websites

    Science DOE Nobel Laureates Alphabetical Listing Chronological Listing A B C D E F G H I J K L M N O P Q R Politzer Richard P. Feynman 1965 Physics 2003 Val L. Fitch 1980 Physics Alexei A. Abrikosov Physics Paul J 1973 Physics 2000 Donald A. Glaser 1960 Physics Alan Heeger Chemistry Sheldon L. Glashow 1979 Physics

  6. 33 CFR 100.501 - Special Local Regulations; Marine Events in the Fifth Coast Guard District.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and times of the effective period of the regulation with respect to each event, the geographical area... operation of any vessel participating in the event, at any time it is deemed necessary for the protection of... Railroad Bridge. 56 September—4th or last Sunday Crystal Coast Super Boat Grand Prix Super Boat...

  7. 33 CFR 100.501 - Special Local Regulations; Marine Events in the Fifth Coast Guard District.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and times of the effective period of the regulation with respect to each event, the geographical area... the event, or the operation of any vessel participating in the event, at any time it is deemed... Crystal Coast Grand Prix North Carolina East Sports, Inc. N/P The waters of Bogue Sound, adjacent to...

  8. 33 CFR 100.106 - Freeport Grand Prix, Long Beach, NY.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Long Island to the south of Long Beach, New York. The regulated area is one and one quarter (11/4) miles south of Long Beach and three and one quarter (31/4) miles north of the northern boundary of... quarter miles southwest of Jones Inlet breakwater at coordinates 40-33-42 North; 073-35-43 West. (2...

  9. 33 CFR 100.106 - Freeport Grand Prix, Long Beach, NY.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of Long Island to the south of Long Beach, New York. The regulated area is one and one quarter (11/4) miles south of Long Beach and three and one quarter (31/4) miles north of the northern boundary of... quarter miles southwest of Jones Inlet breakwater at coordinates 40-33-42 North; 073-35-43 West. (2...

  10. Local vs Nonlocal States in FeTiO3 Probed with 1s2pRIXS: Implications for Photochemistry

    PubMed Central

    2017-01-01

    Metal–metal charge transfer (MMCT) is expected to be the main mechanism that enables the harvesting of solar light by iron–titanium oxides for photocatalysis. We have studied FeTiO3 as a model compound for MMCT with 1s2pRIXS at the Fe K-edge. The high-energy resolution XANES enables distinguishing five pre-edge features. The three first well distinct RIXS features are assigned to electric quadrupole transitions to the localized Fe* 3d states, shifted to lower energy by the 1s core–hole. Crystal field multiplet calculations confirm the speciation of divalent iron. The contribution of electric dipole absorption due to local p-d mixing allowed by the trigonal distortion of the cation site is supported by DFT and CFM calculations. The two other nonlocal features are assigned to electric dipole transitions to excited Fe* 4p states mixed with the neighboring Ti 3d states. The comparison with DFT calculations demonstrates that MMCT in ilmenite is favored by the hybridization between the Fe 4p and delocalized Ti 3d orbitals via the O 2p orbitals. PMID:28872322

  11. Local vs Nonlocal States in FeTiO3 Probed with 1s2pRIXS: Implications for Photochemistry.

    PubMed

    Hunault, Myrtille O J Y; Khan, Wilayat; Minár, Jan; Kroll, Thomas; Sokaras, Dimosthenis; Zimmermann, Patric; Delgado-Jaime, Mario U; de Groot, Frank M F

    2017-09-18

    Metal-metal charge transfer (MMCT) is expected to be the main mechanism that enables the harvesting of solar light by iron-titanium oxides for photocatalysis. We have studied FeTiO 3 as a model compound for MMCT with 1s2pRIXS at the Fe K-edge. The high-energy resolution XANES enables distinguishing five pre-edge features. The three first well distinct RIXS features are assigned to electric quadrupole transitions to the localized Fe* 3d states, shifted to lower energy by the 1s core-hole. Crystal field multiplet calculations confirm the speciation of divalent iron. The contribution of electric dipole absorption due to local p-d mixing allowed by the trigonal distortion of the cation site is supported by DFT and CFM calculations. The two other nonlocal features are assigned to electric dipole transitions to excited Fe* 4p states mixed with the neighboring Ti 3d states. The comparison with DFT calculations demonstrates that MMCT in ilmenite is favored by the hybridization between the Fe 4p and delocalized Ti 3d orbitals via the O 2p orbitals.

  12. Conception et calibration d'un sonoreacteur pour l'oxydation de la cellulose par le systeme TEMPO/NaOCl/NaBr

    NASA Astrophysics Data System (ADS)

    Paquin, Michel

    Avec le contexte economique actuel dans le domaine des pates et papiers au Canada, l'industrie se doit de diversifier ses produits mis en marche. La fermeture de plus de 20 usines depuis 2005, une baisse du PIB de l'industrie de 1,4 milliard CAD entre 1999--2008, une baisse de la demande de 2,4 %, une diminution du prix de la pate de 20,9 % depuis juillet 2009. La delocalisation du secteur vers l'Asie et l'hemisphere sud sont autant de raisons pour laquelle l'industrie se doit d'etre a l'avant plan de nouvelle technologie a base de fibre de bois. Pour augmenter leur rentabilite, l'industrie se doit de diversifier ses produits dans d'autres secteurs que le simple fabricant de papier impression-ecriture. Sa diversification passe par l'elaboration de nouveaux papiers a valeur ajoutee (papier conducteur, papier bioactif, etc.), par l'utilisation de la biomasse forestiere pour la production d'energie, par l'utilisation de la biomasse forestiere pour l'elaboration d'une plateforme de chimie verte, par l'utilisation de la lignine pour le developpement de polymeres et par l'utilisation de la fibre cellulosique pour la fabrication de nanomateriaux. La fabrication de nanofibrille de cellulose peut devenir un des produits qui servira a diversifier la production des usines de pates et papiers. Les nanofibrilles de cellulose possedent des proprietes mecaniques et chimiques exceptionnelles. Les nanofibrilles de cellulose sont fabriquees a partir d'une oxydation selective de la pate kraft de feuillu avec le systeme TEMPO-NaOCl-NaBr. L'oxydation selective de l'alcool primaire en C6 du monomere de glucose sous forme de carboxylates engendre une modification chimique de la cellulose qui accroit l'hydrophilicite des fibrilles. Suite a cette oxydation, nous devons effectuer une desintegration mecanique de la fibre kraft de feuillu oxydee pour separer les fibrilles. Le processus d'oxydation de la fibre par le systeme TEMPO-NaOCl-NaBr et sa defibrillation par la suite engendre une grande consommation d'energie et de reactif qui rend le procede difficilement accessible au milieu industriel. L'utilisation des ultrasons lors de la reaction d'oxydation permet de reduire de 50% le temps de reaction et d'autant la consommation de produits chimiques. Actuellement le processus d'oxydation s'effectue en mode discontinu pour une quantite de 20 grammes de pate dans un reacteur en verre dans un bain a ultrason. L'objectif principal de ce travail est d'elaborer un sonoreacteur en mode semi-continu afin d'etre en mesure de transferer une reaction d'oxydation du mode discontinu en mode semi-continu. Le transfert de reaction sera effectue en realisant la calibration de l'activite acoustique des deux differents reacteurs, discontinu et semi-continu, par la methode de Weissler. La methode de Weissler quantifie le taux de production radicalaire en mesurant la formation d'iode moleculaire d'une solution aqueuse d'iodure de potassium sous ultrason. Suite a sa calibration, le sonoreacteur pilote (mode semi-continu) a demontre une augmentation de la production radicalaire de 683 % a 170 kHz en comparaison avec l'utilisation d'un bain a ultrason a la meme frequence. Lors de la reaction d'oxydation, la puissance optimale utilisee dans le bain a ultrason a 170 kHz est de 1000 W. La puissance utilisee selon les resultats de calibration obtenue dans le sonoreacteur pilote est de 125 W soit une diminution de l'energie appliquee de 87,5 %. Lors de la reaction d'oxydation, le taux de production des groupements carboxylates est de 2,6 mmol COOH kg/min dans le bain a ultrason et de 6,87 mmol COOH kg/min dans le sonoreacteur pilote soit une augmentation de 164% du taux de formation. Selon les resultats obtenus, l'utilisation d'un sonoreacteur en mode continu peut etre envisageable pour la reaction d'oxydation de la cellulose par le systeme TEMPO-NaOCl-NaBr en industrie au niveau industriel.

  13. Written on the Writer's Face: Facial Width-to-Height Ratio among Nominees and Laureates of the Nobel Prize in Literature

    ERIC Educational Resources Information Center

    Lebuda, Izabela; Karwowski, Maciej

    2016-01-01

    This study examined the relationship between facial width-to-height ratio (fWHR), an established marker of testosterone level and dominance, and eminent writers' achievement. The fWHR of laureates (N = 39) and nominees (N = 247) of the Nobel Prize in Literature 1901-1950 was measured together with historiometric data. It was demonstrated that…

  14. Message from the Worldwide Ahmadiyya Muslim Community

    NASA Astrophysics Data System (ADS)

    Ahmad, Mirza Masroor

    2008-07-01

    Abdus Salam was an Ahmadi Muslim from Pakistan, a renowned theoretical physicist who received the Nobel Prize in 1979 for his work in electroweak theory. Although he was the first Muslim Nobel Laureate, Pakistan's military dictator at that time could not admit that its brilliant scientist was a Muslim citizen. Dr Salam's entire award was devoted to the furtherance of education: he did not spend a penny on himself or his family...

  15. Nobel Chemistry in the Laboratory: Synthesis of a Ruthenium Catalyst for Ring-Closing Olefin Metathesis--An Experiment for the Advanced Inorganic or Organic Laboratory

    ERIC Educational Resources Information Center

    Greco, George E.

    2007-01-01

    An experiment for the upper-level undergraduate laboratory is described in which students synthesize a ruthenium olefin metathesis catalyst, then use the catalyst to carry out the ring-closing metathesis of diethyl diallylmalonate. The olefin metathesis reaction was the subject of the 2005 Nobel Prize in chemistry. The catalyst chosen for this…

  16. Air Force Office of Scientific Research, 1993 Research Highlights.

    DTIC Science & Technology

    1993-01-01

    used to describe the behavior of critical point phenomena by Nobel laureate Dr. Kenneth Wilson. Their research has produced useful engineering...40 years of its existence, AFOSR has supported the work of about two dozen scientists who, later, have been awarded the Nobel prize as well as a...locations and types of sensor or actuator elements that are suitable for structurally- integrated nondestructive evaluation ( NDE ) systems. The basic

  17. Advanced Computational Models for Fabric-Reinforced Composites

    DTIC Science & Technology

    2001-10-01

    composites. Trans-Science Corporation 3655 Nobel Drive Suite 440 San Diego, CA 92122-1005 Tel (858) 459-1240 http://www.compositesolutionsinc.com...also based in XP! Material Suppliers San Diego, recently developed the only Newsletters comprehensive design software for the seismic NDT, NDE , NDI...composite bus. Trans-Science Corporation 3655 Nobel Drive Suite 440 San Diego, CA 92122-1005 Tel (858) 459-1240 Fax (858) 459-0210 •’(S-HOME SERVICES

  18. The 2017 Nobel Prize in Chemistry: cryo-EM comes of age.

    PubMed

    Shen, Peter S

    2018-03-01

    The 2017 Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson for "developing cryo-electron microscopy (cryo-EM) for the high-resolution structure determination of biomolecules in solution." This feature article summarizes some of the major achievements leading to the development of cryo-EM and recent technological breakthroughs that have transformed the method into a mainstream tool for structure determination.

  19. NASA STS-132 Air and Space Museum

    NASA Image and Video Library

    2010-07-26

    Dr. John Mather, NASA Goddard Space Flight Center scientist and Nobel Laureate, center, presents Gen. John R. “Jack” Dailey, director of the Smithsonian National Air and Space Museum, left, with a a replica of Mather’s Nobel Prize medal that flew in space aboard STS-132, as astronaut Piers Sellers looks on, during a ceremony at the museum, Tuesday, July 27, 2010, in Washington. Photo Credit: (NASA/Paul E. Alers)

  20. Energetics Applications for the Oil and Gas Industry

    DOE PAGES

    Brinsden, Mark; Boock, Andrea; Baum, Dennis

    2015-08-07

    Here, early motivation and use of energetic materials in the Western World by Alfred Nobel was intended to facilitate mining, construction, and demolition activities. The motivation for the work was the recognized need for a safer energetic material as an alternate to unstabilized nitroglycerine. The invention of dynamite by Nobel was widely adopted in the civilian world and brought a fortune to Nobel, resulting in the formation of the annual Nobel Prize awards, recognizing significant achievements across many fields of endeavour. Nonetheless, further development of energetics was primarily motivated by and funded for military purposes, rather than civilian usage. Andmore » indeed much investment has been given to the development and characterization of military energetics and their application. An example application is the precision shaped charge, primarily developed as a means of focusing energy in a narrow metallic jet for deep penetration of heavy armor. However, the largest costumer today and for many years for shaped charges is not the military, but rather the oil and gas industry, which has adapted the military technology for perforation of oil and gas wells. While there are similar aspects to desired penetration capabilities in both applications, there are enough differences to warrant energetics R & D focused on oil and gas industry needs.« less

  1. Special Issue on "Neutrino Oscillations: Celebrating the Nobel Prize in Physics 2015" in Nuclear Physics B

    NASA Astrophysics Data System (ADS)

    Ohlsson, Tommy

    2016-07-01

    In 2015, the Nobel Prize in Physics was awarded jointly to Takaaki Kajita from the Super-Kamiokande Collaboration and Arthur B. McDonald from the SNO Collaboration ;for the discovery of neutrino oscillations, which shows that neutrinos have mass;. Furthermore, the Daya Bay, K2K and T2K, KamLAND, SNO, and Super-Kamiokande Collaborations shared the Fundamental Physics Breakthrough Prize the same year. In order to celebrate this successful and fruitful year for neutrino oscillations, the editors and the publisher of Nuclear Physics B decided to publish a Special Issue on neutrino oscillations. We invited prominent scientists in the area of neutrino physics that relates to neutrino oscillations to write contributions for this Special Issue, which was open to both original research articles as well as review articles. The authors of this Special Issue consist of e.g. the two Nobel Laureates, International Participants of the Nobel Symposium 129 on Neutrino Physics at Haga Slott in Enköping, Sweden (August 19-24, 2004), selected active researchers, and members from large experimental collaborations with major results in the last ten years. In total, this Special Issue consists of 28 contributions. Please note that the cover of this Special Issue contains a figure from each of the 26 contributions that have figures included.

  2. LHC Nobel Symposium Proceedings

    NASA Astrophysics Data System (ADS)

    Ekelöf, Tord

    2013-12-01

    In the summer of 2012, a great discovery emerged at the Large Hadron Collider (LHC) at CERN in Geneva. A plethora of new precision data had already by then been collected by the ATLAS and CMS experiments at LHC, providing further extensive support for the validity of the Standard Model of particle physics. But what now appeared was the first evidence for what was not only the last unverified prediction of the Standard Model, but also perhaps the most decisive one: the prediction made already in 1964 of a unique scalar boson required by the theory of François Englert and Peter Higgs on how fundamental particles acquire mass. At that moment in 2012, it seemed particularly appropriate to start planning a gathering of world experts in particle physics to take stock of the situation and try to answer the challenging question: what next? By May 2013, when the LHC Nobel Symposium was held at the Krusenberg Mansion outside Uppsala in Sweden, the first signs of a great discovery had already turned into fully convincing experimental evidence for the existence of a scalar boson of mass about 125 GeV, having properties compatible with the 50-year-old prediction. And in October 2013, the evidence was deemed so convincing that the Swedish Royal Academy of Sciences awarded the Nobel Prize in Physics to Englert and Higgs for their pioneering work. At the same time the search at the LHC for other particles, beyond those predicted by the Standard Model, with heavier masses up to—and in some cases beyond—1 TeV, had provided no positive result. The triumph of the Standard Model seems resounding, in particular because the mass of the discovered scalar boson is such that, when identified with the Higgs boson, the Standard Model is able to provide predictions at energies as high as the Planck mass, although at the price of accepting that the vacuum would be metastable. However, even if there were some feelings of triumph, the ambience at the LHC Nobel Symposium was more one of puzzlement. The apparent absence of hints in the LHC experimental data of new phenomena that could relate to dark matter, dark energy, the dominance of matter over antimatter in the Universe, the unification of the strong and the electroweak interactions and their further unification with gravity left the Symposium with no guidance as to how to answer the question: what next? And in experimental fundamental science it is not the confirmation of already established theories that thrills the most; it is the appearance of the unexpected that creates the greatest excitement. However, the LHC is only at the beginning of its voyage into the uncharted territories of higher energies and smaller dimensions that it was built for, so the possibilities for unexpected discoveries are only starting to be explored. The LHC will start up again in 2015 with nearly twice its previous energy and with increased luminosity—new discoveries might then appear sooner than we even dare hope for! The LHC Nobel Symposium was attended by about 60 invited participants and lasted four days. The program was divided into seven sessions; QCD and Heavy Ion Physics, B Physics, Electroweak Physics, The Higgs Boson, Connections to Neutrino Physics and Astroparticle Physics, Beyond the Standard Model and Forward Look. There were 27 plenary invited talks given by participants, each followed by lively discussions. All but one of the speakers have submitted write-ups of their talks for these proceedings. We are hopeful that the remaining talk will be published in a forthcoming issue of Physica Scripta . I am gratified that Professor Roland Allen has agreed to write a paper on the essence of the Higgs boson discovery to be published in Physica Scripta , intended for undergraduate students and educated physicists, regardless of their field of research. I wish to express my deep gratitude to all Speakers and Participants in the Symposium, to the Members of the Local and International Organizing Committees, to the referees of these Proceedings and to the staff at Uppsala University, in particular my Administrative Assistant for the Symposium, Marja Fahlander, at the Royal Swedish Academy of Sciences, at the Nobel Foundation and at the Institute of Physics Publishing Company for Physica Scripta for realizing this enlightening Symposium at its proceedings. The Nobel Symposium was financed by the Nobel Foundation. Tord Ekelöf Chair of the LHC Nobel Symposium Local Organizing Committee and LHC Nobel Guest Editor for the Symposium Proceedings Members of the Local Organizing Committee of the LHC Nobel Symposium Tord Ekelöf (Uppsala University, Chair) Kerstin Jon-And (Stockholms University) Bengt Lund-Jensen (Royal Institute of Technology) Anders Oskarsson (Lunds University) Torsten Åkesson (Lund University) Barbro Åsman (Swedish Royal Academy of Sciences) Members of the International Advisory Committee of the LHC Nobel Symposium Pierluigi Campana (INFN Frascati) Fabiola Gianotti (CERN) Paolo Giubellino (INFN-Torino) Joe Incandela (UC Santa Barbara) Young-Kee Kim (FNAL) Michelangelo Mangano (CERN) Lisa Randall (Harvard University)

  3. Swift Trust in Hastily Formed Networks

    DTIC Science & Technology

    2002-01-01

    in the Engineering School. 1983 Grand Prix Award, Sales Promotion Association of Australia A national award received for the best promotion of the...deposit of over $500. The average deposit was over $2,000. 1983 Best Small Budget Award, Sales Promotion Association of Australia A national award...Australian Sales Promotion Awards. Implemented the introduction of new financial services such as automatic bill paying and telephone bill paying. Planned

  4. Durable Hybrid Coatings Annual Performance Report (2009)

    DTIC Science & Technology

    2009-10-01

    results based on lengths of cracks on different topcoat/primer combinations. Non- topcoated High gloss Low gloss White enamel 0 5 10 15 20 25 30...SR-285, showed extensive cracking and delamination upon cure and, thus, were eliminated from further investigation. Figure 3.15 shows the viscosity...solids polyurethane gloss enamel (AKZO NOBEL 646-58-7925 with AKZO NOBEL X- 501 curing component) and a Mg-rich primer developed at NDSU.16 In this

  5. Values most extolled in Nobel Peace Prize speeches.

    PubMed

    Kinnier, Richard T; Kernes, Jerry L; Hayman, Jessie Wetherbe; Flynn, Patricia N; Simon, Elia; Kilian, Laura A

    2007-11-01

    The authors randomly selected 50 Nobel Peace Prize speeches and content analyzed them to determine which values the speakers extolled most frequently. The 10 most frequently mentioned values were peace (in 100% of the speeches), hope (92%), security (86%), justice (85%), responsibility (81%), liberty (80%), tolerance (79%), altruism (75%), God (49%), and truth (38%). The authors discuss the interplay of these values in the modern world and implications regarding the search for universal moral values.

  6. Light is a Messenger - The Life and Science of William Lawrence Bragg

    NASA Astrophysics Data System (ADS)

    Hunter, Graeme K.

    2004-10-01

    Light is a Messenger , is the first biography of William Lawrence Bragg, who was only 25 when he won the 1915 Nobel Prize in Physics-the youngest person ever to win a Nobel Prize. It describes how bragg discovered how to use X-rays to determine the arrangement of atoms in crystals and his pivotal role in developing this technique to the point that the structures of the most complex molecules known to man-the proteins and nucelic acids-could be solved. Although Bragg's Nobel Prize was for Physics, his research profoundly affected chemistry and the new field of molecular biology, of which he became a founding figure. This book explains how these revolutionary scientific events occurred while Bragg struggled to emerge from the shadow of his father, Sir William Bragg, and amidst a career-long rivalry with the brilliant American chemist, Linus Pauling.

  7. [The 2009 Nobel Prize in Medicine and its surprising message: lifestyle is associated with telomerase activity].

    PubMed

    Falus, András; Marton, István; Borbényi, Erika; Tahy, Adám; Karádi, Pál; Aradi, János; Stauder, Adrienne; Kopp, Mária

    2010-06-13

    The 2009 Nobel Prize in Physiology and Medicine was awarded to three scientists for their pioneer research on telomeres - and the enzyme that forms them - telomerase. Their work highlighted the considerable connection between the length of telomeres and intensive changes in lifestyle and nutrition (Ornish method) as well as behavioral and psychological factors. In this review the various elements of molecular, cell biological, nutritional and lifestyle changes are introduced and discussed.

  8. Birth of neutrino astrophysics (Nobel Lecture).

    PubMed

    Koshiba, Masatoshi

    2003-07-14

    The KamiokaNDE experiment for the observation of proton decay, an array of photomultipliers containing over 3000 tons of water, allowed the observation of charged particles travelling faster than the velocity of light in water. The subsequently developed Super-KamiokaNDE could be used to measure the amounts, the path, the energies, and the oscillation parameters of neutrinos, generated either by supernova explosions in the sun, or in the atmosphere. This work was awarded the 2002 Nobel Prize in Physics.

  9. Color variation induced by abutments in the superior anterior maxilla: an in vitro study in the pig gingiva.

    PubMed

    Atash, Ramin; Boularbah, Mohamed-Reda; Sibel, Cetik

    2016-12-01

    The aim of this work is to evaluate different types of materials used for making implant abutments, by means of an in vitro study and a review of the literature, in order to identify the indications for a better choice of an implant-supported restoration in the anterior section. 5 implant abutments were tested in a random order in the superior anterior maxilla of pig gingiva (n = 8): titanium dioxide (Nobel Biocare); zirconium dioxide, Standard BO shade (Nobel Biocare, Kloten, Switzerland); zirconium dioxide, Light BI shade (Nobel Biocare); zirconium dioxide, Intense A 3.5 shade (Nobel Biocare); and aluminium oxide. Each abutment was tested for 2 mm and 3 mm thickness. To determine color variation, VITA Easyshade Advance spectrophotometer (Vita Zahnfabrik, Bad Sackingen, Germany) was used. Results showed that the color variation induced by the abutment would be affected by the abutment material and gingival thickness, when the gingival thickness is 2 mm. All materials except zirconium dioxide (Standard shade) caused a visible change of color. Then, as the thickness of the gingiva increased to 3 mm, the color variation was attenuated in a significant manner and became invisible for all types of abutments, except those made of aluminium oxide. Zirconium dioxide is the material causing the lowest color variation at 2 mm and at 3 mm, whereas aluminium oxide causes the highest color variation no matter the thickness.

  10. The 2008 Lindau Nobel Laureate Meeting: Robert Huber, Chemistry 1988. Interview by Klaus J. Korak.

    PubMed

    Huber, Robert

    2008-11-25

    Robert Huber and his colleagues, Johann Deisenhofer and Hartmut Michel, elucidated the three-dimensional structure of the Rhodopseudomonas viridis photosynthetic reaction center. This membrane protein complex is a basic component of photosynthesis - a process fundamental to life on Earth - and for their work, Huber and his colleagues received the 1988 Nobel Prize in Chemistry. Because structural information is central to understanding virtually any biological process, Huber likens their discovery to "switching on the light" for scientists trying to understand photosynthesis. Huber marvels at the growth of structural biology since the time he entered the field, when crystallographers worked with hand-made instruments and primitive computers, and only "a handful" of crystallographers would meet annually in the Bavarian Alps. In the "explosion" of structural biology since his early days of research, Huber looks to the rising generation of scientists to solve the remaining mysteries in the field - such as the mechanisms that underlie protein folding. A strong proponent of science mentorship, Huber delights in meeting young researchers at the annual Nobel Laureate Meetings in Lindau, Germany. He hopes that among these young scientists is an "Einstein of biology" who, he says with a twinkle in his eye, "doesn't know it yet." The interview was conducted by JoVE co-founder Klaus J. Korak at the Lindau Nobel Laureate Meeting 2008 in Lindau, Germany.

  11. The 2008 Lindau Nobel Laureate Meeting: Robert Huber, Chemistry 1988

    PubMed Central

    Huber, Robert

    2008-01-01

    Robert Huber and his colleagues, Johann Deisenhofer and Hartmut Michel, elucidated the three-dimensional structure of the Rhodopseudomonas viridis photosynthetic reaction center. This membrane protein complex is a basic component of photosynthesis – a process fundamental to life on Earth – and for their work, Huber and his colleagues received the 1988 Nobel Prize in Chemistry. Because structural information is central to understanding virtually any biological process, Huber likens their discovery to “switching on the light” for scientists trying to understand photosynthesis. Huber marvels at the growth of structural biology since the time he entered the field, when crystallographers worked with hand-made instruments and primitive computers, and only “a handful” of crystallographers would meet annually in the Bavarian Alps. In the “explosion” of structural biology since his early days of research, Huber looks to the rising generation of scientists to solve the remaining mysteries in the field – such as the mechanisms that underlie protein folding. A strong proponent of science mentorship, Huber delights in meeting young researchers at the annual Nobel Laureate Meetings in Lindau, Germany. He hopes that among these young scientists is an “Einstein of biology” who, he says with a twinkle in his eye, “doesn’t know it yet.” The interview was conducted by JoVE co-founder Klaus J. Korak at the Lindau Nobel Laureate Meeting 2008 in Lindau, Germany. PMID:19066525

  12. Lunar Roving Vehicle gets speed workout by Astronaut John Young

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The Lunar Roving Vehicle (LRV) gets a speed workout by Astronaut John W. Young in the 'Grand Prix' run during the third Apollo 16 extravehicular activity (EVA-3) at the Descartes landing site. Note the front wheels of the LRV are off the ground. This view is a frame from motion picture film exposed by a 16mm Maurer camera held by Astronaut Charles M. Duke Jr.

  13. Artemisinin, a miracle of traditional Chinese medicine.

    PubMed

    Kong, Ling Yi; Tan, Ren Xiang

    2015-12-19

    The 2015 Nobel Prize in Physiology or Medicine, shared by Professor Youyou Tu, focused worldwide attention on artemisinin, a natural product antimalarial drug inspired by traditional Chinese medicine (TCM). This is the first Nobel Prize in natural sciences presented to a Chinese scientist for her impactful research work in China in collaboration with other Chinese scientists. We are delighted to provide the background and implications of the discovery of artemisinin, along with our personal viewpoints toward the affordability of modern medicines from natural products.

  14. ["When all of you will be forgotten, the name Israel will still be shining" : James Israel (1848-1926): a career in the German Empire and his nomination for the Nobel Prize].

    PubMed

    Moll, Friedrich H; Halling, Thorsten; Hansson, Nils; Fangerau, Heiner

    2017-03-01

    In 1902, the Berlin Jewish urologist James Israel was nominated for the Nobel Prize in physiology or medicine. Taking scholar, social, and political aspects into consideration, this biographical essay traces how James Israel gained a sound scientific reputation especially in kidney surgery within Imperial Germany and its antisemitic attitude and how he promoted urology to become a specialty in its own right.

  15. Multiscale modeling of nerve agent hydrolysis mechanisms: a tale of two Nobel Prizes

    NASA Astrophysics Data System (ADS)

    Field, Martin J.; Wymore, Troy W.

    2014-10-01

    The 2013 Nobel Prize in Chemistry was awarded for the development of multiscale models for complex chemical systems, whereas the 2013 Peace Prize was given to the Organisation for the Prohibition of Chemical Weapons for their efforts to eliminate chemical warfare agents. This review relates the two by introducing the field of multiscale modeling and highlighting its application to the study of the biological mechanisms by which selected chemical weapon agents exert their effects at an atomic level.

  16. ECONOMICS NOBEL: Dealing With Biases and Discrete Choices.

    PubMed

    Seife, C

    2000-10-20

    This year's Bank of Sweden Prize in Economic Sciences, given in honor of Alfred Nobel, goes to two researchers who gave the field of microeconomics--the study of individuals' economic behavior--new tools to help draw conclusions from imperfect data. James Heckman of the University of Chicago wins half of this year's prize for coming up with ways to deal with selection biases. Daniel McFadden of the University of California, Berkeley, tackled a different conundrum: how to quantify discrete choices rather than continuous ones.

  17. A great honor and a huge challenge for China: You-you TU getting the Nobel Prize in Physiology or Medicine.

    PubMed

    Yuan, Da; Yang, Xue; Guo, Jun-Chao

    2016-05-01

    Public excitement over the award of the 2015 Nobel Prize in Physiology or Medicine to the Chinese medical scientist You-you TU for the discovery of a herbal anti-malarial, may mislead the Chinese people into believing that traditional Chinese herbal medi-cine can be used to cure all disease without any ad-verse effects. The aim of this paper is to explain the advantages and disadvantages of herbal traditional Chinese medicine (TCM) objectively.

  18. Abdus Salam at Imperial College

    NASA Astrophysics Data System (ADS)

    Duff, M. J.

    The death of Abdus Salam in 1996 was a great loss not only to his family and the scientific community; it was a loss to all mankind. For he was not only one of the finest physicists of the twentieth century, having unified two of the four fundamental forces of nature, but he dedicated his life to the betterment of science and education in the developing world. So although he won the Nobel Prize for physics, a Nobel Peace Prize would have been equally appropriate...

  19. How to get the Nobel Prize in physics

    NASA Astrophysics Data System (ADS)

    Nordling, Carl

    1995-01-01

    Every year, on the 10th of December, one piece is added to the history of science. This is the day when the Nobel Prizes are awarded to those scientists who "during the preceding year have conferred the greatest benefit on mankind". The Nobel Prize carries the highest prestige and fame of all distinctions in the world of science. There have been many speculations regarding the prize: What effect does it have on its recipients? Does it boost their research activities or does it kill them? Is it merely an after-the-fact recognition of important steps in the history of science, or does it also create history by changing the directions along which science develops? What role does it play in the sociology of science? Is it a prize for leaders of big research teams or is there a preference for the genius working completely on his own? Are there equal opportunities for men and women, for Swedes and Russians, for black and white? Where does one find the track that leads to Stockholm?

  20. Alfred nobel.

    PubMed

    Holmin, L R

    1996-10-01

    Alfred Nobel never spoke publicly about his problems of ill health, but a detailed, subjective record has recently been published in the form of 216 letters written to his mistress during an 18-year period. His descriptions of constant pain, debilitating migraine, and "paralyzing" fatigue permit a hypothesis that he might have had a long struggle with fibromyalgia. This does not preclude his having suffered other illnesses as well. He thought he had heart disease, which his physicians denied until his final years, when he was diagnosed with angina pectoris. He died of a cerebral hemorrhage in 1896 at the age of 63. His letters describe a 30-year search for diagnosis from the best physicians in Europe. He was ridiculed by many people as a hypochondriac, and he never received a diagnosis for "the pain that will not go away." This may well have contributed to the bitterness and depression of his final years. Increasing worldwide interest and research in this elusive syndrome will hopefully prevent a repetition of the Nobel story of a century ago.

  1. Editorial

    NASA Astrophysics Data System (ADS)

    Rudolph, Dirk; Elding, Lars-Ivar; Fahlander, Claes; Åberg, Sven

    2016-12-01

    Science often develops most vigorously through challenging studies of extreme phenomena. Superheavy elements fall into such a category. What is the heaviest element that can exist in Nature? Driven by the continued search for an anticipated "island of stability" of superheavy atomic nuclei and the understanding of their underlying nuclear (in)stability and atomic structure hence chemical properties, the past decades have seen a tremendous progress in experimental ingenuity and theoretical methodology to study and characterize superheavy elements. Therefore, we are very grateful that the Nobel Foundation [1] approved and, jointly with the Knut and Alice Wallenberg Foundation [2], provided the financial resources to organize and conduct the Nobel Symposium NS160, entitled Chemistry and Physics of Heavy and Superheavy Elements. These symposia "are devoted to areas of science where breakthroughs are occurring or deal with other topics of primary cultural or social significance" [1]. About three symposia are held each year, roughly every fourth symposium promotes a topic in physics as primary research area, and from about every third symposium a contemporary Nobel Price is being awarded.

  2. A Simple Index for the High-Citation Tail of Citation Distribution to Quantify Research Performance in Countries and Institutions

    PubMed Central

    Rodríguez-Navarro, Alonso

    2011-01-01

    Background Conventional scientometric predictors of research performance such as the number of papers, citations, and papers in the top 1% of highly cited papers cannot be validated in terms of the number of Nobel Prize achievements across countries and institutions. The purpose of this paper is to find a bibliometric indicator that correlates with the number of Nobel Prize achievements. Methodology/Principal Findings This study assumes that the high-citation tail of citation distribution holds most of the information about high scientific performance. Here I propose the x-index, which is calculated from the number of national articles in the top 1% and 0.1% of highly cited papers and has a subtractive term to discount highly cited papers that are not scientific breakthroughs. The x-index, the number of Nobel Prize achievements, and the number of national articles in Nature or Science are highly correlated. The high correlations among these independent parameters demonstrate that they are good measures of high scientific performance because scientific excellence is their only common characteristic. However, the x-index has superior features as compared to the other two parameters. Nobel Prize achievements are low frequency events and their number is an imprecise indicator, which in addition is zero in most institutions; the evaluation of research making use of the number of publications in prestigious journals is not advised. Conclusion The x-index is a simple and precise indicator for high research performance. PMID:21647383

  3. A simple index for the high-citation tail of citation distribution to quantify research performance in countries and institutions.

    PubMed

    Rodríguez-Navarro, Alonso

    2011-01-01

    Conventional scientometric predictors of research performance such as the number of papers, citations, and papers in the top 1% of highly cited papers cannot be validated in terms of the number of Nobel Prize achievements across countries and institutions. The purpose of this paper is to find a bibliometric indicator that correlates with the number of Nobel Prize achievements. This study assumes that the high-citation tail of citation distribution holds most of the information about high scientific performance. Here I propose the x-index, which is calculated from the number of national articles in the top 1% and 0.1% of highly cited papers and has a subtractive term to discount highly cited papers that are not scientific breakthroughs. The x-index, the number of Nobel Prize achievements, and the number of national articles in Nature or Science are highly correlated. The high correlations among these independent parameters demonstrate that they are good measures of high scientific performance because scientific excellence is their only common characteristic. However, the x-index has superior features as compared to the other two parameters. Nobel Prize achievements are low frequency events and their number is an imprecise indicator, which in addition is zero in most institutions; the evaluation of research making use of the number of publications in prestigious journals is not advised. The x-index is a simple and precise indicator for high research performance.

  4. Alfred Nobel and His Prizes: From Dynamite to DNA

    PubMed Central

    Lichtman, Marshall A.

    2017-01-01

    Alfred Nobel was one of the most successful chemists, inventors, entrepreneurs, and businessmen of the late nineteenth century. In a decision later in life, he rewrote his will to leave virtually all his fortune to establish prizes for persons of any nationality who made the most compelling achievement for the benefit of mankind in the fields of chemistry, physics, physiology or medicine, literature, and peace among nations. The prizes were first awarded in 1901, five years after his death. In considering his choice of prizes, it may be pertinent that he used the principles of chemistry and physics in his inventions and he had a lifelong devotion to science, he suffered and died from severe coronary and cerebral atherosclerosis, and he was a bibliophile, an author, and mingled with the literati of Paris. His interest in harmony among nations may have derived from the effects of the applications of his inventions in warfare (“merchant of death”) and his friendship with a leader in the movement to bring peace to nations of Europe. After some controversy, including Nobel’s citizenship, the mechanisms to choose the laureates and make four of the awards were developed by a foundation established in Stockholm; the choice of the laureate for promoting harmony among nations was assigned to the Norwegian Storting, another controversy. The Nobel Prizes after 115 years remain the most prestigious of awards. This review describes the man, his foundation, and the prizes with a special commentary on the Nobel Prize in Physiology or Medicine. PMID:28786809

  5. Responses to the Competitive State Anxiety Inventory-2 by the Athletes Participated in the (IJF) Judo Grand Prix Competition, Samsun 2015 in Turkey

    ERIC Educational Resources Information Center

    Agaoglu, Yavuz Selim

    2016-01-01

    The judo is a popular sport which people engaged in more than 178 countries at any age in the world. Besides its popularity, the studies on this field continue to increase gradually. The purpose of this study, therefore, is to measure pre-competition anxieties, and to evaluate data obtained of the pre-competition concerns of the judo athletes who…

  6. Apollo 16: Nothing So Hidden

    NASA Technical Reports Server (NTRS)

    1972-01-01

    This film shows the landing and the three lunar traverses in the highland region of the moon, near the crater descartes. It includes an astronaut's eye view from the rover, lunar grand prix, discovery of the house-sized rock, lunar lift-off and eva 173,000 miles above the earth. Microphones and cameras in mission control record the emergency problem solving during the prelanding crisis and the reactions of scientists on earth as the astronauts explore the moon.

  7. OPENING ADDRESS: Heterostructures in Semiconductors

    NASA Astrophysics Data System (ADS)

    Grimmeiss, Hermann G.

    1996-01-01

    Good morning, Gentlemen! On behalf of the Nobel Foundation, I should like to welcome you to the Nobel Symposium on "Heterostructures in Semiconductors". It gives me great pleasure to see so many colleagues and old friends from all over the world in the audience and, in particular, to bid welcome to our Nobel laureates, Prof. Esaki and Prof. von Klitzing. In front of a different audience I would now commend the scientific and technological importance of heterostructures in semiconductors and emphatically emphasise that heterostructures, as an important contribution to microelectronics and, hence, information technology, have changed societies all over the world. I would also mention that information technology is one of the most important global key industries which covers a wide field of important areas each of which bears its own character. Ever since the invention of the transistor, we have witnessed a fantastic growth in semiconductor technology, leading to more complex functions and higher densities of devices. This development would hardly be possible without an increasing understanding of semiconductor materials and new concepts in material growth techniques which allow the fabrication of previously unknown semiconductor structures. But here and today I will not do it because it would mean to carry coals to Newcastle. I will therefore not remind you that heterostructures were already suggested and discussed in detail a long time before proper technologies were available for the fabrication of such structures. Now, heterostructures are a foundation in science and part of our everyday life. Though this is certainly true, it is nevertheless fair to say that not all properties of heterostructures are yet understood and that further technologies have to be developed before a still better understanding is obtained. The organisers therefore hope that this symposium will contribute not only to improving our understanding of heterostructures but also to opening new perspectives for future applications. We are most grateful that you agreed with the special format of the symposium which clearly does not follow conven- tional conferences. Allow me to call your special attention once again to two main differences: The presentations are not review papers praising already achieved break-throughs but introductions to a list of open questions and issues for which our understanding is still unsatisfactory. To give such presentations requires courage and scientific integrity. I would like to thank all speakers now already for their willingness to cope with such a difficult task. We have allocated at least 50 minutes for discussion after each presentation not only for discussing the paper as such but, if possible, to find answers to the open questions. If one or several participants in the audience during the discussion think they can contribute to improving our understanding of heterostructures, they are invited to write their ideas up and, if the referees agree, we are more than happy to publish these ideas in the proceedings. We admit that the program is rather demanding. For that reason, we plan to have a break on Thursday afternoon by first going to Denmark and touring the Hamlet castle of Kronborg. We then sail back to Sweden and will be hosted by the Krapperup castle where we will have a candle-light dinner and thereafter a baroque music concert featuring the Concerto Copenhagen. All participants, observers, and accompanying spouses are invited and we hope you will all enjoy the excur- sion. The local organising committee acknowledges with pleasure the financial and all other support received from the Nobel Foundation and the Nobel Institute of Physics as well as the initial initiative taken by the chairman of the Nobel Com- mittee for Physics, Prof. Nordling, who was the first to suggest this Nobel Symposium on "Heterostructures in Semicon- ductors". Special thanks also to the members of the program committee who have been of inestimable value in putting together the program and suggesting speakers and potential participants. Moreover, I should like to thank Mrs. Medborg, Dr. Olajos, Dr. Mats Kleverman and in particular Dr. Ask who took care of all time-consuming negotiations and details. Without their help, the Symposium would not be what it is. The Nobel Foundation, the Nobel Committee for Physics, the Nobel Institute of Physics and the local organisers hope that you will enjoy the Symposium and I promise you, we will all do our best to make your stay as pleasant as possible and this Symposium a success. Once again welcome to Arild and the Symposium!

  8. On the Human Aspect of Nobel Prize

    NASA Astrophysics Data System (ADS)

    Durand, G.

    1990-10-01

    One night, Nico invited for dinner all his postdoc and graduate students, in a German restaurant close to Harvard Square. Just before we were to pay for our meal, he told us: "Tomorrow, we shall know the Nobel prize winner. Can you people make a guess on his name?" All my colleagues nominated great physicists. In my turn, I suggested naively (and perhaps nationalistically) the name of Alfred Kastler who had been my thesis adviser. "Come on," joked Nico, "I know a lot of physicists who would deserve it much better.."

  9. The Beatles, the Nobel Prize, and CT scanning of the chest.

    PubMed

    Goodman, Lawrence R

    2010-01-01

    From its first test scan on a mouse, in 1967, to current medical practice, the CT scanner has become a core imaging tool in thoracic diagnosis. Initially financed by money from Beatles' record sales, the first patient scan was performed in 1971. Only 8 years later, a Nobel Prize in Physics and Medicine was awarded to Hounsfield and Cormack for their discovery. This article traces the history of CT scanner development and how each technical advance expanded chest diagnostic frontiers. Chest imaging now accounts for 30% of all CT scanning.

  10. Revisiting the 1981 Nobel Prize to Roger Sperry, David Hubel, and Torsten Wiesel on the occasion of the centennial of the Prize to Golgi and Cajal.

    PubMed

    Berlucchi, Giovanni

    2006-12-01

    In 1981 the Nobel Prize for Medicine or Physiology was awarded to Roger Sperry for his work on the functional specialization of the cerebral hemispheres, and to David Hubel and Torsten Wiesel for their work on information processing in the visual system. The present paper points to some important links between the work of Sperry and that of Hubel and Wiesel and to their influences on neuroscience in the best tradition going back to Cajal.

  11. “Advice to the medical students in my service”: the rediscovery of a golden book by Jean Hamburger, father of nephrology and of medical humanities

    PubMed Central

    2013-01-01

    Jean Hamburger (1909–1992) is considered the founder of the concept of medical intensive care (réanimation médicale) and the first to propose the name Nephrology for the branch of medicine dealing with kidney diseases. One of the first kidney grafts in the world (with short-term success), in 1953, and the first dialysis session in France, in 1955, were performed under his guidance. His achievements as a writer were at least comparable: Hamburger was awarded several important literary prizes, including prix Femina, prix Balzac and the Cino del Duca prize (1979), awarded, among others, to Jorge Luis Borges and Konrad Lorenz. Here we would like to offer a selected reading of a “golden” book, “Conseils aux étudiants en medicine de mon service” (“Advice to the Medical Students in my Service”), the first book dedicated to patient-physician relationship in Nephrology, written when dialysis and transplantation were becoming clinical options (1963). The themes include: the central role of the patient, who should be known by name, profession, life style, and not by disease; the importance of the setting of the care; the need for truth-telling and for leaving hope; the role of research not only in the progression of science, but also in the daily clinical practice. PMID:23497662

  12. "Advice to the medical students in my service": the rediscovery of a golden book by Jean Hamburger, father of nephrology and of medical humanities.

    PubMed

    Barbara, Piccoli Giorgina

    2013-03-15

    Jean Hamburger (1909-1992) is considered the founder of the concept of medical intensive care (réanimation médicale) and the first to propose the name Nephrology for the branch of medicine dealing with kidney diseases. One of the first kidney grafts in the world (with short-term success), in 1953, and the first dialysis session in France, in 1955, were performed under his guidance. His achievements as a writer were at least comparable: Hamburger was awarded several important literary prizes, including prix Femina, prix Balzac and the Cino del Duca prize (1979), awarded, among others, to Jorge Luis Borges and Konrad Lorenz.Here we would like to offer a selected reading of a "golden" book, "Conseils aux étudiants en medicine de mon service" ("Advice to the Medical Students in my Service"), the first book dedicated to patient-physician relationship in Nephrology, written when dialysis and transplantation were becoming clinical options (1963). The themes include: the central role of the patient, who should be known by name, profession, life style, and not by disease; the importance of the setting of the care; the need for truth-telling and for leaving hope; the role of research not only in the progression of science, but also in the daily clinical practice.

  13. A comparative study of the accuracy between plastic and metal impression transfer copings for implant restorations.

    PubMed

    Fernandez, Monica A; Paez de Mendoza, Carmen Y; Platt, Jeffrey A; Levon, John A; Hovijitra, Suteera T; Nimmo, Arthur

    2013-07-01

    A precise transfer of the position and orientation of the antirotational mechanism of an implant to the working cast is particularly important to achieve optimal fit of the final restoration. This study evaluated and compared the accuracy of metal and plastic impression copings for use in a full-arch mandibular edentulous simulation with four implants. Metal and plastic impression transfer copings for two implant systems, Nobel Biocare™ Replace and Straumann SynOcta®, were assessed on a laboratory model to simulate clinical practice. The accuracy of producing stone casts using these plastic and metal impression transfer copings was measured against a standard prosthetic framework consisting of a cast gold bar. A total of 20 casts from the four combinations were obtained. The fit of the framework on the cast was tested by a noncontact surface profilometer, the Proscan 3D 2000 A, using the one-screw test. The effects of implant/system and impression/coping material on gap measurements were analyzed using repeated measures ANOVA. The findings of this in vitro study were as follows: plastic copings demonstrated significantly larger average gaps than metal for Straumann (p = 0.001). Plastic and metal copings were not significantly different for Nobel (p = 0.302). Nobel had significantly larger average gaps than Straumann for metal copings (p = 0.003). Nobel had marginally smaller average gaps than Straumann (p = 0.096) for plastic copings. The system-by-screw location interaction was significant as well (p < 0.001), indicating significant differences among the four screw locations, but the location differences were not the same for the two systems. A rank transformation of the data was necessary due to the nonnormal distribution of the gap measurements. No adjustments were made for multiple comparisons. The metal impression copings were more accurate than plastic copings when using the Straumann system, and there was no difference between metal and plastic copings for the Nobel Replace system. The system-by-screw location was not conclusive, showing no correlation within each system. © 2013 by the American College of Prosthodontists.

  14. The Nobel Prize as a Reward Mechanism in the Genomics Era: Anonymous Researchers, Visible Managers and the Ethics of Excellence

    PubMed Central

    2010-01-01

    The Human Genome Project (HGP) is regarded by many as one of the major scientific achievements in recent science history, a large-scale endeavour that is changing the way in which biomedical research is done and expected, moreover, to yield considerable benefit for society. Thus, since the completion of the human genome sequencing effort, a debate has emerged over the question whether this effort merits to be awarded a Nobel Prize and if so, who should be the one(s) to receive it, as (according to current procedures) no more than three individuals can be selected. In this article, the HGP is taken as a case study to consider the ethical question to what extent it is still possible, in an era of big science, of large-scale consortia and global team work, to acknowledge and reward individual contributions to important breakthroughs in biomedical fields. Is it still viable to single out individuals for their decisive contributions in order to reward them in a fair and convincing way? Whereas the concept of the Nobel prize as such seems to reflect an archetypical view of scientists as solitary researchers who, at a certain point in their careers, make their one decisive discovery, this vision has proven to be problematic from the very outset. Already during the first decade of the Nobel era, Ivan Pavlov was denied the Prize several times before finally receiving it, on the basis of the argument that he had been active as a research manager (a designer and supervisor of research projects) rather than as a researcher himself. The question then is whether, in the case of the HGP, a research effort that involved the contributions of hundreds or even thousands of researchers worldwide, it is still possible to “individualise” the Prize? The “HGP Nobel Prize problem” is regarded as an exemplary issue in current research ethics, highlighting a number of quandaries and trends involved in contemporary life science research practices more broadly. PMID:20730106

  15. The History of Molecular Structure Determination Viewed through the Nobel Prizes

    NASA Astrophysics Data System (ADS)

    Jensen, William P.; Palenik, Gus J.; Suh, Il-Hwan

    2003-07-01

    For the past 100 years, with only a few exceptions during war times, Nobel Prizes have been awarded annually to men and women who have made exceptionally important discoveries in science. In thirteen of those years, prizes were awarded to individuals whose contributions helped explain the molecular world of matter through interactions of waves or particles with atoms. From William C. Röntgen, who received the very first Nobel Prize in Physics in 1901 for his work with X-rays, to von Laue and the father-and-son Bragg team in the second decade of the century, who used X-rays to understand atomic arrangements, much progress had been made revealing secrets at the molecular level of matter. In the 1930s Debye, Davisson, and Thomson revealed further information using, among other techniques, diffraction of electrons by matter. In the 1960s Crick, Watson, Wilkins, Perutz, Kendrew, and Hodgkin received Nobel Prizes for revealing structures of significantly more complex molecules including the DNA double helix, myoglobin, hemoglobin, and vitamin B12. In the 1970s and 1980s Lipscomb would be recognized for organizing our picture of boron hydrides, Klug would use electron diffraction to determine structures of important nucleic acid protein complexes, Hauptman and Karle would bring us a powerful new way to solve structures, and Deisenhofer, Huber, and Michel would determine the three-dimensional structure of a photosynthetic reaction center. Finally, in 1994 Brockhouse and Shull were recognized for their work with neutrons. Crystallography has been used to answer increasingly complex questions in the past, and will certainly remain an important tool in the future.

  16. Towards Producing Black Nobel Laureates Affiliated with ``African Universities''

    NASA Astrophysics Data System (ADS)

    Kenneth, Jude

    While Africa has produced a handful Nobel laureate in literature and peace, it has continued to shy away from producing any in the other categories. The reason is not farfetched; our university system is not up to standard. It is saddening that in this century, African countries place emphasis on certificates and not on knowledge. This has made the continent produce students that lack the intellectual capability, experimental ability, fundamental training, creativity, and motivation to excel except they get a foreign training. It is this backdrop that precipitated the research into the methods of teaching and research in universities across Africa. The study is designed to identify the problems and proffer solution to them. Two important questions immediately come to mind. (1) What factors account for the difficulty in producing Nobel laureates affiliated with African universities? (2) What strategies could be adopted to improve teaching and research in African universities? Several factors were investigated which revolve around funding, the competence of the lecturers, quality of students admitted, attitude of the students, parents and government. Nigerian universities were investigated and important deductions were made. During the study an inquiry was made on the method of instruction at various universities, from result obtained, the study therefore concluded that adequate funding, the presence of erudite scholars and brilliant minds will produce future Nobel laureate affiliated with the continent. The study therefore recommended admission and employment of only students and lecturers who have got a thing for academics into the universities and adequate funding of universities and research centres.

  17. Dissecting slander and crying for justice: Carlos Chagas and the Nobel Prize of 1921.

    PubMed

    Bestetti, Reinaldo B; Cardinalli-Neto, Augusto

    2013-10-03

    Chagas disease was discovered by Carlos Chagas in 1909. Chagas worked at Oswaldo Cruz Institute, where the bases of experimental medicine were settled in Brazil, and that had no connection with the Faculty of Medicine of Rio de Janeiro. Chagas had several enemies at Oswaldo Cruz Institute mainly because of his election to Head of Service in 1910, and for the position of Oswaldo Cruz Directorship in 1917. Furthermore, Chagas gained enemies at Faculty of Medicine of Rio de Janeiro, which did not like to see the economical political autonomy of Oswaldo Cruz Institute. This allowed the Institute not only to perform top experimental research, but also to take the leadership of research in the country. Chagas was nominated to the Nobel Prize of 1921 in December, 1920. None was awarded the Nobel Prize in that year. He seems to have been evaluated by the Noble Committee of Karolinska Institute from March to May of 1921. At that time, his enemies were denying his discovery of Trypanosoma cruzi, a key point in Chagas' nomination by Karolinska Institute, and giving no epidemiological importance for the disease. By the same way, the obligation of small pox vaccination was tarnishing his public image. Having taken into account the epidemiologic importance of Chagas disease, the strong historical mistake in the process of Chagas evaluation, and the inequity behind all these facts, we insist on a posthumous Nobel Prize for the man who made the most complete medical-scientist discovery of all time. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  18. Joining Dental Ceramic Layers With Glass

    PubMed Central

    Saied, MA; Lloyd, IK; Haller, WK; Lawn, BR

    2011-01-01

    Objective Test the hypothesis that glass-bonding of free-form veneer and core ceramic layers can produce robust interfaces, chemically durable and aesthetic in appearance and, above all, resistant to delamination. Methods Layers of independently produced porcelains (NobelRondo™ Press porcelain, Nobel BioCare AB and Sagkura Interaction porcelain, Elephant Dental) and matching alumina or zirconia core ceramics (Procera alumina, Nobel BioCare AB, BioZyram yttria stabilized tetragonal zirconia polycrystal, Cyrtina Dental) were joined with designed glasses, tailored to match thermal expansion coefficients of the components and free of toxic elements. Scanning electron microprobe analysis was used to characterize the chemistry of the joined interfaces, specifically to confirm interdiffusion of ions. Vickers indentations were used to drive controlled corner cracks into the glass interlayers to evaluate the toughness of the interfaces. Results The glass-bonded interfaces were found to have robust integrity relative to interfaces fused without glass, or those fused with a resin-based adhesive. Significance The structural integrity of the interfaces between porcelain veneers and alumina or zirconia cores is a critical factor in the longevity of all-ceramic dental crowns and fixed dental prostheses. PMID:21802131

  19. The mantle of the heavens: Reflections on the 2014 Nobel Prize for medicine or physiology.

    PubMed

    Morris, Richard G M

    2015-06-01

    The award of the Nobel Prize in Medicine or Physiology in 2014 for the discovery of place and grid cells was both a personal award to three great scientists and also a mark of the maturity of systems neuroscience as a discipline. This article offers both personal and scientific reflections on these discoveries, detailing both how getting to know all three winners had an impact on my life and the research questions that we shared in common work together. It ends with brief reflections on three important outstanding questions. © 2015 Wiley Periodicals, Inc.

  20. Paul Ehrlich: the Nobel Prize in physiology or medicine 1908.

    PubMed

    Piro, Anna; Tagarelli, Antonio; Tagarelli, Giuseppe; Lagonia, Paolo; Quattrone, Aldo

    2008-01-01

    We wish to commemorate Paul Ehrlich on the centennial of his being awarded the Nobel Prize in Physiology or Medicine in 1908. His studies are now considered as milestones in immunology: the morphology of leukocytes; his side-chain theory where he defined the cellular receptor for first time; and his clarification of the difference between serum therapy and chemotherapy. Ehrlich also invented the first chemotherapeutic drug: compound 606, or Salvarsan. We have used some original documents from the Royal Society of London, where Ehrlich was a fellow, and from Leipzig University, where he took a degree in medicine.

  1. Optics pioneers scoop Nobel prize

    NASA Astrophysics Data System (ADS)

    Banks, Michael

    2009-11-01

    Three physicists who carried out pioneering work in former industrial research labs have picked up this year's Nobel Prize for Physics. One half of the SEK 10m prize has been awarded to Charles Kao, 75, for his work at the UK-based Standard Telephones and Cables (STC) on the transmission of light in optical fibres, which underpinned the telecommunications revolution. The other half of the prize is shared between Willard Boyle, 85, and George Smith, 79, of Bell Laboratories in New Jersey, US, for inventing the charge-coupled device (CCD) - an imaging semiconductor circuit that forms the basis of most digital cameras.

  2. Characterization and Application of a Large Animal Model of Penetrating Ballistic Brain Injury (PBBI)

    DTIC Science & Technology

    2012-03-01

    Jump, South American Track and Field Grand Prix. Cuenca, Ecuador , 2004. - Goodwill Ambassador, Ministry of Tourism of Ecuador . Quito, Ecuador , 2000...they only comprise 11.5% of all-cause injury deaths and have a case fatality rate (CFR) of less than 1% [33]. In contrast, penetrating TBIs due to...because many cases of mild closed TBI are not detected post-injury and because the bodily distribution of wounds for all combat casualties (e.g. Wounded In

  3. Alternatives to Anti-Personnel Landmines (Solutions de remplacement aux mines antipersonnel)

    DTIC Science & Technology

    2003-05-01

    remplacement ont un prix : elles sont plus pesantes sur le plan logistique et impliquent des risques opérationnels pour les forces de l’OTAN. En...très importante, de l’interopérabilité dans le transfert de secteurs qui ont été minés par un pays non-signataire de la Convention d’Ottawa. Le...SEINE CEDEX, FRANCE RTO TECHNICAL REPORT 40(I) Alternatives to Anti-Personnel Landmines (Solutions de remplacement aux mines antipersonnel) Military

  4. Aspects épidemiocliniques et évolutifs chez 157 cas de leishmaniose cutanée au Maroc

    PubMed Central

    Hjira, Naoufal; Frikh, Rachid; Marcil, Tarik; Lamsyah, Hanane; Oumakhir, Siham; Baba, Noureddine; Boui, Mohammed

    2014-01-01

    Connue au Maroc depuis la fin du XIX siècle, la leishmaniose cutanée (LC) constitue un problème de santé publique dans notre pays. Le but de notre travail est de décrire le profil épidémioclinique et l’évolution post thérapeutique chez les patients ayant une leishmaniose cutanée dans notre contexte. Nous avons effectué une étude rétrospective, basée sur l'exploitation des dossiers de malades ayant présenté une leishmaniose cutanée confirmée entre janvier 2003 et décembre 2012. Nous avons colligés 157 cas de leishmaniose cutanée. L’âge moyen des patients était de 34.5 ans avec des extrêmes de 6 ans à 63 ans. Le sex-ratio était de 2.34 H/F. La durée d’évolution moyenne des lésions était de 3,6 mois avec des extrêmes de 2 semaines à 10 mois. Les lésions étaient uniques dans 29.5% des cas. Les lésions siégeaient sur membres dans 63%. La forme ulcèro- croûteuse touchait plus de 48%. Le Glucantime était utilisé dans 29.3% des cas, l'azote liquide était utilisé chez 111 autres. L’évolution post-thérapeutique était favorable avec disparition quasi-complète des lésions dans un délai variant de 6 à 10 semaines, au prix de cicatrices inesthétiques chez 14 patients. La leishmaniose cutanée continue à poser un vrai problème de santé publique dans notre pays. L’émergence de formes sévères et résistantes à travers le monde doit inciter à multiplier et renforcer les mesures prophylactiques. PMID:25309671

  5. History of Diabetes Insipidus.

    PubMed

    Valenti, Giovanna; Tamma, Grazia

    2016-02-01

    Under physiological conditions, fluid and electrolyte homoeostasis is maintained by the kidney adjusting urine volume and composition according to body needs. Diabetes Insipidus is a complex and heterogeneous clinical syndrome affecting water balance and characterized by constant diuresis, resulting in large volumes of dilute urine. With respect to the similarly named Diabetes Mellitus, a disease already known in ancient Egypt, Greece and Asia, Diabetes Insipidus has been described several thousand years later. In 1670s Thomas Willis, noted the difference in taste of urine from polyuric subjects compared with healthy individuals and started the differentiation of Diabetes Mellitus from the more rare entity of Diabetes Insipidus. In 1794, Johann Peter Frank described polyuric patients excreting nonsaccharine urine and introduced the term of Diabetes Insipidus. An hystorical milestone was the in 1913, when Farini successfully used posterior pituitary extracts to treat Diabetes Insipidus. Until 1920s the available evidence indicated Diabetes Insipidus as a disorder of the pituitary gland. In the early 1928, De Lange first observed that some patients with Diabetes Insipidus did not respond to posterior pituitary extracts and subsequently Forssman and Waring in 1945 established that the kidney had a critical role for these forms of Diabetes Insipidus resistant to this treatment. In 1947 Williams and Henry introduced the term Nephrogenic Diabetes Insipidus for the congenital syndrome characterized by polyuria and renal concentrating defect resistant to vasopressin. In 1955, du Vigneaud received the 1955 Nobel Prize in chemistry for the first synthesis of the hormone vasopressin representing a milestone for the treatment of Central Diabetes Insipidus.

  6. Diabetes insipidus: celebrating a century of vasopressin therapy.

    PubMed

    Qureshi, Sana; Galiveeti, Sneha; Bichet, Daniel G; Roth, Jesse

    2014-12-01

    Diabetes mellitus, widely known to the ancients for polyuria and glycosuria, budded off diabetes insipidus (DI) about 200 years ago, based on the glucose-free polyuria that characterized a subset of patients. In the late 19th century, clinicians identified the posterior pituitary as the site of pathology, and pharmacologists found multiple bioactivities there. Early in the 20th century, the amelioration of the polyuria with extracts of the posterior pituitary inaugurated a new era in therapy and advanced the hypothesis that DI was due to a hormone deficiency. Decades later, a subset of patients with polyuria unresponsive to therapy were recognized, leading to the distinction between central DI and nephrogenic DI, an early example of a hormone-resistant condition. Recognition that the posterior pituitary had 2 hormones was followed by du Vigneaud's Nobel Prize winning isolation, sequencing, and chemical synthesis of oxytocin and vasopressin. The pure hormones accelerated the development of bioassays and immunoassays that confirmed the hormone deficiency in vasopressin-sensitive DI and abundant levels of hormone in patients with the nephrogenic disorder. With both forms of the disease, acquired and inborn defects were recognized. Emerging concepts of receptors and of genetic analysis led to the recognition of patients with mutations in the genes for 1) arginine vasopressin (AVP), 2) the AVP receptor 2 (AVPR2), and 3) the aquaporin 2 water channel (AQP2). We recount here the multiple skeins of clinical and laboratory research that intersected frequently over the centuries since the first recognition of DI.

  7. Chronobiology --2017 Nobel Prize in Physiology or Medicine.

    PubMed

    Yuan, Li; Li, Yi-Rou; Xu, Xiao-Dong

    2018-01-20

    Chronobiology is a field of biology that examines the generation of biological rhythms in various creatures and in many parts of body, and their adaptive fitness to solar- and lunar-related periodic phenomena. The synchronization of internal circadian clocks with external timing signals confers accurate phase response and tissue homeostasis. Herein we state a series of studies on circadian rhythms and introduce the brief history of chronobiology. We also present a detailed timeline of the discoveries on molecular mechanisms controlling circadian rhythm in Drosophila, which was awarded the 2017 Nobel Prize in Physiology or Medicine. The latest findings and new perspectives are further summarized to indicate the significance of circadian research.

  8. Youyou Tu: significance of winning the 2015 Nobel Prize in Physiology or Medicine.

    PubMed

    Liu, Wenxiu; Liu, Yue

    2016-02-01

    Youyou Tu, a female scientist at the China Academy of Traditional Chinese Medicine in Beijing, is the first Chinese winner of the Nobel Prize in Physiology or Medicine. Based on the study of recipes which had been used for thousands of years to treat fever, Tu's group discovered that the plant artemesia annua, sweet wormwood, showed substantial inhibition of rodent malaria parasites. Her achievement and experience have inspired other researchers and emphasized the development of traditional Chinese medicine. Her award has led to a heated discussion about scientific research investment, fair treatment of research staff, and intellectual property right (IPR) protection in China.

  9. Robert F. Furchgott, Nobel laureate (1916–2009) – a personal reflection

    PubMed Central

    Martin, William

    2009-01-01

    Robert F. Furchgott, pharmacologist and joint winner of the Nobel Prize for Medicine or Physiology (1998) died on the 12th of May 2009 aged 92. By unlocking the astonishingly diverse biological actions of nitric oxide, Furchgott leaves behind a rich legacy that has both revolutionized our understanding of human physiology and stimulated new and exciting opportunities for drug development in a wide range of pathological conditions. In this article, William Martin, who worked with Furchgott for 2 years (1983–1985), following the exciting discovery of endothelium-derived relaxing factor/nitric oxide, pays tribute to his close friend and colleague. PMID:19681890

  10. Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker's yeast fuel advances in biomedical research

    PubMed Central

    Levine, Beth; Klionsky, Daniel J.

    2017-01-01

    Autophagy is an ancient pathway in which parts of eukaryotic cells are self-digested within the lysosome or vacuole. This process has been studied for the past seven decades; however, we are only beginning to gain a molecular understanding of the key steps required for autophagy. Originally characterized as a hormonal and starvation response, we now know that autophagy has a much broader role in biology, including organellar remodeling, protein and organelle quality control, prevention of genotoxic stress, tumor suppression, pathogen elimination, regulation of immunity and inflammation, maternal DNA inheritance, metabolism, and cellular survival. Although autophagy is usually a degradative pathway, it also participates in biosynthetic and secretory processes. Given that autophagy has a fundamental role in many essential cellular functions, it is not surprising that autophagic dysfunction is associated with a wide range of human diseases. Genetic studies in various fungi, particularly Saccharomyces cerevisiae, provided the key initial breakthrough that led to an explosion of research on the basic mechanisms and the physiological connections of autophagy to health and disease. The Nobel Committee has recognized this breakthrough by the awarding of the 2016 Nobel Prize in Physiology or Medicine for research in autophagy. PMID:28039434

  11. Learning by Viewing - Nobel Labs 360

    NASA Technical Reports Server (NTRS)

    Mather, John C.

    2013-01-01

    First of all, my thanks to the Nobel Lindau Foundation for their inspiration and leadership in sharing the excitement of scientific discovery with the public and with future scientists! I have had the pleasure of participating twice in the Lindau meetings, and recently worked with the Nobel Labs 360 project to show how we are building the world's greatest telescope yet, the James Webb Space Telescope (JWST). For the future, I see the greatest challenges for all the sciences in continued public outreach and inspiration. Outreach, so the public knows why we are doing what we are doing, and what difference it makes for them today and in the long-term future. Who knows what our destiny may be? It could be glorious, or not, depending on how we all behave. Inspiration, so that the most creative and inquisitive minds can pursue the scientific and engineering discoveries that are at the heart of so much of human prosperity, health, and progress. And, of course, national and local security depend on those discoveries too; scientists have been working with "the government" throughout recorded history. For the Lindau Nobel experiment, we have a truly abundant supply of knowledge and excitement, through the interactions of young scientists with the Nobelists, and through the lectures and the video recordings we can now share with the whole world across the Internet. But the challenge is always to draw attention! With 7 billion inhabitants on Earth, trying to earn a living and have some fun, there are plenty of competing opportunities and demands on us all. So what will draw attention to our efforts at Lindau? These days, word of mouth has become word of (computer) mouse, and ideas propagate as viruses ( or memes) across the Internet according to the interests of the participants. So our challenge is to find and match those interests, so that the efforts of our scientists, photographers, moviemakers, and writers are rewarded by our public. The world changes every day, so there is no one way to go, and everything is an experiment - sounds scientific, yes? I think our partnership with Volker Steger in the Nobel Labs 360 is one of the most interesting I have seen. Computer viewers can see our scientific habitats and begin to experience being there in person, panning a viewpoint up, down, and all around us, and seeing or hearing explanations of what we are doing.

  12. Excrétion rénale des ions divalents après homotransplantation rénale

    PubMed Central

    Cartier, F.; Popovtzer, M. M.; Robinette, J.; Pinggera, W. F.; Halgrimson, C. G.; Starzl, T. E.

    2010-01-01

    RÉSUMÉ L’élimination rénale des ions divalents, celle du Na et du K, ont été étudiées de façon comparative dans les suites immédiates de l’homotransplantation rénale chez 6 patients. Durant la période initiale polyurique (> 3ml/mn), le taux d’excrétion du Ca filtré (Cca/Ccr), du Mg, du P, du Na et du K, est élevé et il existe une corrélation étroite et quasi constante entre l’élimination du Ca, du Mg et du Na ; la corrélation n’est pas constante entre l’élimination du Na et du K, du Mg et du K. Pendant les deux jours suivants, le taux d’excrétion diminue, sauf pour le P ; il existe encore une corrélation entre l’excrétion du Ca, du Mg et du Na, non entre celle du Na et du K, du Mg et du K. L’excrétion du Ca l’emporte sur celle du Na au cours de la première période, non au cours de la seconde. A la lumière de ces données, on envisage l’intervention possible de divers facteurs, tels l’inflation hydrosique et l’hyperazotémie préalables, l’ischémie rénale contemporaine de la transplantation, les effets de la dénervation rénale, du traitement cortisonique, de l’hyperparathyroïdie et ceux des modifications circulatoires rénales. PMID:4574592

  13. The 2014 Nobel Prize in Physiology or Medicine: a spatial model for cognitive neuroscience.

    PubMed

    Burgess, Neil

    2014-12-17

    Understanding how the cognitive functions of the brain arise from its basic physiological components has been an enticing final frontier in science for thousands of years. The Nobel Prize in Physiology or Medicine 2014 was awarded one half to John O'Keefe, the other half jointly to May-Britt Moser and Edvard I. Moser "for their discoveries of cells that constitute a positioning system in the brain." This prize recognizes both a paradigm shift in the study of cognitive neuroscience, and some of the amazing insights that have followed from it concerning how the world is represented within the brain. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. From engaged citizen to lone hero: Nobel Prize laureates on British television, 1962-2004.

    PubMed

    Gouyon, Jean-Baptiste

    2018-05-01

    Between 1962 and 2004, Nobel Prize laureates appear in the British television science programme Horizon in various roles, denoting differing understandings of science in relation to society and culture. These representations are the outcome of an interplay of cultural and institutional factors. They vary with the broadcasting environment. Notably, the article establishes that the choice of presenting scientists as heroic characters in strongly determined storylines from the late-1990s onwards originates in a reaction to institutional imperatives as a means to preserve the existence of the Horizon series. The article shows that exigencies of the institutional context in which media professionals operate are major factors influencing the representation of science in public.

  15. Radiation risk and nuclear medicine: An interview with a Nobel Prize winner

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yalow, R.S.

    1995-12-01

    In a speech given years ago at the Veterans Administration Medical Center, Bronx, NY, Rosalyn S. Yalow, 1977 Nobel Prize recipient for her invention of radioimmunoassay, made several salient points on the perception of fear or hazards from exposure to low-level radiation and low-level radioactive wastes. For the past three years, Yalow has been concerned with the general fear of radiation. In this interview, Newsline solicited Yalow`s views on public perceptions on radiation risk and what the nuclear medicine community can do to emphasize the fact that, if properly managed, the use of isotopes in medicine and other cases ismore » not dangerous.« less

  16. Selman A. Waksman, winner of the 1952 Nobel Prize for physiology or medicine.

    PubMed

    Woodruff, H Boyd

    2014-01-01

    The history of the discovery and development of streptomycin is reviewed here from the personal standpoint of a member of Dr. Selman Waksman's antibiotic screening research team. The team approach of eight individuals illustrates how the gradual enhancement of the screening methodology was developed. I illustrate three study periods with key aspects in the development of streptomycin which led to a Nobel Prize being granted to Professor Waksman. One item not previously emphasized is the employment of a submerged culture technique for large-scale production of streptomycin, thus enabling rapid animal testing and human clinical trials with Mycobacterium tuberculosis. Another is that purified streptomycin was shown by Dr. Waksman to be distinctly different from the substances called natural products, which are no longer patentable in the United States; therefore, streptomycin was found to be patentable. A third item not previously emphasized is his emphasis on the screening of actinomycetes, including the newly named Streptomyces genus. All of these factors contributed to the success of streptomycin in the treatment of tuberculosis. In combination, their successes led to Dr. Waksman's department becoming a new pharmacological research area, specializing in drug discovery. These unique accomplishments all burnish the prior rationales used by the Karolinska Institute in granting Dr. Waksman alone the 1952 Nobel Prize for Physiology or Medicine.

  17. Biomedical applications of green synthesized Nobel metal nanoparticles.

    PubMed

    Khan, Zia Ul Haq; Khan, Amjad; Chen, Yongmei; Shah, Noor S; Muhammad, Nawshad; Khan, Arif Ullah; Tahir, Kamran; Khan, Faheem Ullah; Murtaza, Behzad; Hassan, Sadaf Ul; Qaisrani, Saeed Ahmad; Wan, Pingyu

    2017-08-01

    Synthesis of Nobel metal nanoparticles, play a key role in the field of medicine. Plants contain a substantial number of organic constituents, like phenolic compounds and various types of glycosides that help in synthesis of metal nanoparticles. Synthesis of metal nanoparticles by green method is one of the best and environment friendly methods. The major significance of the green synthesis is lack of toxic by-products produced during metal nanoparticle synthesis. The nanoparticles, synthesized by green method show various significant biological activities. Most of the research articles report the synthesized nanoparticles to be active against gram positive and gram negative bacteria. Some of these bacteria include Escherichia coli, Bacillus subtilis, Klebsiella pneumonia and Pseudomonas fluorescens. The synthesized nanoparticles also show significant antifungal activity against Trichophyton simii, Trichophyton mentagrophytes and Trichophyton rubrum as well as different types of cancer cells such as breast cancer cell line. They also exhibit significant antioxidant activity. The activities of these Nobel metal nano-particles mainly depend on the size and shape. The particles of small size with large surface area show good activity in the field of medicine. The synthesized nanoparticles are also active against leishmanial diseases. This research article explores in detail the green synthesis of the nanoparticles and their uses thereof. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Tadeus Reichstein, co-winner of the Nobel Prize for Physiology or Medicine: on the occasion of the 110th anniversary of his birth in Poland.

    PubMed

    Wincewicz, Andrzej; Sulkowska, Mariola; Sulkowski, Stanislaw

    2007-01-01

    Tadeus Reichstein (1897-1996) was the first scientist born in Poland to receive the Nobel Prize in Medicine or Physiology (1950) for the "discovery of hormones of the adrenal cortex, their structure and biological effects", as stated by the Nobel Prize Committee. His family being deeply devoted to Polish cultural and historical heritage, his first name was given to him after Tadeus Kosciuszko, a chief commander of the 18th century Polish uprising named the Kosciuszko Insurrection. As a child, he emigrated with his family to Switzerland, where he was much later to become involved in numerous research studies on steroids on an international scale. It was Tadeus Reichstein who isolated and synthesized desoxycorticosterone, which still remains the drug of first choice in the treatment of Addison's disease. Additionally, thanks to his strategy for the mass production of Vitamin C, the cost of this agent was drastically reduced thus enabling its widespread therapeutic use. In our divided world so often torn by tremendous conflicts, there is a great need to both remember and commemorate such distinguished people as Tadeus Reichstein who, despite the apparent "borders" between different nationalities and cultures, have demonstrated through their work the huge need for harmonious collaboration in the development of science.

  19. The combined effect of dismantling for steam sterilization and aging on the accuracy of spring-style mechanical torque devices

    PubMed Central

    Mahshid, Minoo; Sadr, Seyed Jalil; Fayyaz, Ali; Kadkhodazadeh, Mahdi

    2013-01-01

    Purpose This study aimed to assess the combined effect of dismantling before sterilization and aging on the accuracy (±10% of the target torque) of spring-style mechanical torque devices (S-S MTDs). Methods Twenty new S-SMTDs from two different manufacturers (Nobel Biocare and Straumann: 10 of each type) were selected and divided into two groups, namely, case (group A) and control (group B). For sterilization, 100 cycles of autoclaving were performed in 100 sequences. In each sequence, 10 repetitions of peak torque values were registered for aging. To measure and assess the output of each device, a Tohnichi torque gauge was used (P<0.05). Results Before steam sterilization, all of the tested devices stayed within 10% of their target values. After 100 cycles of steam sterilization and aging with or without dismantling of the devices, the Nobel Biocare devices stayed within 10% of their target torque. In the Straumann devices, despite the significant difference between the peak torque and target torque values, the absolute error values stayed within 10% of their target torque. Conclusion Within the limitations of this study, there was no significant difference between the mean and absolute value of error between Nobel Biocare and Straumann S-S MTDs. PMID:24236244

  20. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thiel, Pat

    Ames Laboratory senior scientist and Iowa State University Distinguished Professor of Chemistry Pat Thiel talks about her friend and colleague Dan Shechtman who received the 2011 Nobel Prize for Chemistry.

  1. Toward a Concept of Risk for Effective Military Decision Making

    DTIC Science & Technology

    2007-12-01

    gestion intégrée du risque de 2001 par le Secrétariat du Conseil du Trésor du Canada, (b) de la doctrine interarmées sur la gestion du risque pour les...opérations des FC de 2002 et les documents de politique et les directives de l’intégration de la gestion du risque de 2005 du ministère de la Défense...a) le gouvernement du Canada dans le Cadre de gestion intégrée du risque de

  2. Population, behavioural and physiological responses of an urban population of black swans to an intense annual noise event.

    PubMed

    Payne, Catherine J; Jessop, Tim S; Guay, Patrick-Jean; Johnstone, Michele; Feore, Megan; Mulder, Raoul A

    2012-01-01

    Wild animals in urban environments are exposed to a broad range of human activities that have the potential to disturb their life history and behaviour. Wildlife responses to disturbance can range from emigration to modified behaviour, or elevated stress, but these responses are rarely evaluated in concert. We simultaneously examined population, behavioural and hormonal responses of an urban population of black swans Cygnus atratus before, during and after an annual disturbance event involving large crowds and intense noise, the Australian Formula One Grand Prix. Black swan population numbers were lowest one week before the event and rose gradually over the course of the study, peaking after the event, suggesting that the disturbance does not trigger mass emigration. We also found no difference in the proportion of time spent on key behaviours such as locomotion, foraging, resting or self-maintenance over the course of the study. However, basal and capture stress-induced corticosterone levels showed significant variation, consistent with a modest physiological response. Basal plasma corticosterone levels were highest before the event and decreased over the course of the study. Capture-induced stress levels peaked during the Grand Prix and then also declined over the remainder of the study. Our results suggest that even intensely noisy and apparently disruptive events may have relatively low measurable short-term impact on population numbers, behaviour or physiology in urban populations with apparently high tolerance to anthropogenic disturbance. Nevertheless, the potential long-term impact of such disturbance on reproductive success, individual fitness and population health will need to be carefully evaluated.

  3. Population, Behavioural and Physiological Responses of an Urban Population of Black Swans to an Intense Annual Noise Event

    PubMed Central

    Payne, Catherine J.; Jessop, Tim S.; Guay, Patrick-Jean; Johnstone, Michele; Feore, Megan; Mulder, Raoul A.

    2012-01-01

    Wild animals in urban environments are exposed to a broad range of human activities that have the potential to disturb their life history and behaviour. Wildlife responses to disturbance can range from emigration to modified behaviour, or elevated stress, but these responses are rarely evaluated in concert. We simultaneously examined population, behavioural and hormonal responses of an urban population of black swans Cygnus atratus before, during and after an annual disturbance event involving large crowds and intense noise, the Australian Formula One Grand Prix. Black swan population numbers were lowest one week before the event and rose gradually over the course of the study, peaking after the event, suggesting that the disturbance does not trigger mass emigration. We also found no difference in the proportion of time spent on key behaviours such as locomotion, foraging, resting or self-maintenance over the course of the study. However, basal and capture stress-induced corticosterone levels showed significant variation, consistent with a modest physiological response. Basal plasma corticosterone levels were highest before the event and decreased over the course of the study. Capture-induced stress levels peaked during the Grand Prix and then also declined over the remainder of the study. Our results suggest that even intensely noisy and apparently disruptive events may have relatively low measurable short-term impact on population numbers, behaviour or physiology in urban populations with apparently high tolerance to anthropogenic disturbance. Nevertheless, the potential long-term impact of such disturbance on reproductive success, individual fitness and population health will need to be carefully evaluated. PMID:23024783

  4. Os isotopes in SNC meteorites and their implications to the early evolution of Mars and Earth

    NASA Technical Reports Server (NTRS)

    Jagoutz, E.; Luck, J. M.; Othman, D. Ben; Wanke, H.

    1993-01-01

    A new development on the measurement of the Os isotopic composition by mass spectrometry using negative ions opened a new field of applications. The Re-Os systematic provides time information on the differentiation of the nobel metals. The nobel metals are strongly partitioned into metal and sulphide phases, but also the generation of silicate melts might fractionate the Re-Os system. Compared to the other isotopic systems which are mainly dating the fractionation of the alkalis and alkali-earth elements, the Re-Os system is expected to disclose entirely new information about the geochemistry. Especially the differentiation and early evolution of the planets such as the formation of the core will be elucidated with this method.

  5. Nanoscopy—imaging life at the nanoscale: a Nobel Prize achievement with a bright future

    NASA Astrophysics Data System (ADS)

    Blom, Hans; Bates, Mark

    2015-10-01

    A grand scientific prize was awarded last year to three pioneering scientists, for their discovery and development of molecular ‘ON-OFF’ switching which, when combined with optical imaging, can be used to see the previously invisible with light microscopy. The Royal Swedish Academy of Science announced on October 8th their decision and explained that this achievement—rooted in physics and applied in biology and medicine—was awarded with the Nobel Prize in Chemistry for controlling fluorescent molecules to create images of specimens smaller than anything previously observed with light. The story of how this noble switch in optical microscopy was achieved and how it was engineered to visualize life at the nanoscale is highlighted in this invited comment.

  6. William Henry Bragg, man and scientist, Nobel Laureate and First Professor of Physics, University of Adelaide 1886-1909.

    PubMed

    Patterson, John; George, Robert

    2018-03-01

    In London, November 1915, a telegram was received at the home of William Henry Bragg from the secretary of the Academy of Science in Stockholm announcing the award of the Nobel Prize in Physics for "the analysis of crystal structures by means of X-rays". A second similar telegram was addressed to his 25 year old son William Lawrence Bragg (Jenkin, 2008). This article commemorates the centenary of that event and the unveiling of a bust of Sir William Bragg alongside that of his son, Sir Lawrence Bragg, on North Terrace in Adelaide where he spent 23 years of his early career. Copyright © 2018. Published by Elsevier Ltd.

  7. Mrs. Chandrasekhar poses with contest winners

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Mrs. Lalitha Chandrasekhar (left), wife of the late Indian- American Nobel Laureate Subrahmanyan Chandrasekhar, poses with a model of the Chandra X-ray Observatory and the winners of the contest to rename the telescope in the TRW Media Hospitality Tent at the NASA Press Site at KSC. The winners of the contest are Jatila van der Veen (center), academic coordinator and lecturer, Physics Dept., University of Santa Barbara, Calif., and Tyrel Johnson (right), high school student, Laclede, Idaho. The name 'Chandra,' a shortened version of Chandrasekhar's name which he preferred among friends and colleagues, was chosen to honor the Nobel Laureate. 'Chandra' also means 'Moon' or 'luminous' in Sanskrit. The observatory is scheduled to be launched aboard Columbia on Space Shuttle mission STS-93.

  8. The 1973 Nobel Prize for Physiology or Medicine: recognition for behavioral science?

    PubMed

    Dewsbury, Donald A

    2003-09-01

    The Nobel Prize for Physiology or Medicine for 1973 was awarded to 3 ethologists: Karl von Frisch, Konrad Lorenz, and Nikolaas Tinbergen. This was a landmark event in the history of the field of ethology and potentially for the behavioral sciences more broadly. For the first time, the prize was awarded for research of a purely behavioral nature. The language used in making the award emphasized the implications of ethological work for human health and appeared to suggest that more such awards might be forthcoming; few were. The author provides an overview of the 3 men, their work, the events surrounding the award, the controversy that arose, and the significance of the award as viewed in contemporary perspective.

  9. Fullerene discoverers win nobel prize

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rotman, D.

    1996-10-16

    Two Rice University (Houston) chemists, Robert F. Curl and Richard E. Smalley, and a scientist at the University of Sussex (Brighton, U.K.), Harold W. Kroto, have won the 1996 Nobel Prize in Chemistry for the joint discovery of buckminsterfullerenes - soccer ball-shaped carbon molecules. The novel form of carbon, which was initially synthesized by the scientists in 1985 as C{sub 60} and C{sub 70} has led to the development of {open_quotes}an entirely new branch of chemistry... with consequences in such diverse areas as astrochemistry, superconductivity, and material chemistry/physics,{close_quotes} according to the Swedish Academy of Sciences (Stockholm). For chemists, the structuremore » is {open_quotes}uniquely beautiful and satisfying,{close_quotes} the academy says.« less

  10. Single molecules, cells, and super-resolution optics (Presentation Video)

    NASA Astrophysics Data System (ADS)

    Betzig, Eric

    2015-03-01

    In this plenary presentation, Eric Betzig talks about his scientific journey that led to the Nobel Prize. He made waves early in his career by helping to develop a technique known as near-field microscopy, which brought into focus structures that scientists had long considered too small to see with a light microscope. Eric Betzig is a group leader at Janelia Research Campus of the Howard Hughes Medical Institute (HHMI) in Ashburn, VA. He recieved a BS in physics from California Institute of Technology and a PhD in applied and engineering physics from Cornell University. Betzig received the 2014 Nobel Prize in Chemistry, along with William Moerner and Stefan Hell, for their development of super-resolved fluorescence microscopy.

  11. KSC-99pp0975

    NASA Image and Video Library

    1999-07-19

    KENNEDY SPACE CENTER, FLA. -- Mrs. Lalitha Chandrasekhar (left), wife of the late Indian-American Nobel Laureate Subrahmanyan Chandrasekhar, poses with a model of the Chandra X-ray Observatory and the winners of the contest to rename the telescope in the TRW Media Hospitality Tent at the NASA Press Site at KSC. The winners of the contest are Jatila van der Veen (center), academic coordinator and lecturer, Physics Dept., University of Santa Barbara, Calif., and Tyrel Johnson (right), high school student, Laclede, Idaho. The name "Chandra," a shortened version of Chandrasekhar's name which he preferred among friends and colleagues, was chosen to honor the Nobel Laureate. "Chandra" also means "Moon" or "luminous" in Sanskrit. The observatory is scheduled to be launched aboard Columbia on Space Shuttle mission STS-93

  12. An observational cohort study of patients with newly diagnosed digital ulcer disease secondary to systemic sclerosis registered in the EUSTAR database.

    PubMed

    Brand, Monika; Hollaender, Rebecca; Rosenberg, Daniel; Scott, Martin; Hunsche, Elke; Tyndall, Alan; Denaro, Valentina; Carreira, Patricia; Varju, Cecilia; Gabrielli, Barbara; Zingarelli, Stefania; Caramaschi, Paola; Simic-Pasalic, Katarina; Müller-Ladner, Ulf; Vasile, Massimiliano; Mihai, Carina; Rosato, Edoardo; Vacca, Alessandra; Zenone, Thierry; Mohamed, Walid A; Ancuta, Codrina; Zampogna, Giuseppe; Rednic, Simona; Jabaar, Nadia; Belloli, Laura; Pozzi, Maria R; Foti, Rosario; Walker, Ulrich A

    2015-01-01

    This study describes clinical characteristics, prognostic factors, and quality of life in patients with newly diagnosed (incident) digital ulcers (DU). Observational cohort study of 189 consecutive SSc patients with incident DU diagnosis identified from the EUSTAR database (22 centres in 10 countries). Data were collected from medical charts and during one prospective visit between 01/2004 and 09/2010. Median age at DU diagnosis was 51 years, majority of patients were female (88%), and limited cutaneous SSc was the most common subtype (61%). At incident DU diagnosis, 41% of patients had one DU and 59% had ≥2 DU; at the prospective visit 52% had DU. Pulmonary arterial hypertension (PAH) and multiple DU at diagnosis were associated with presence of any DU at the prospective visit (odds ratios: 4.34 and 1.32). During the observation period (median follow-up was 2 years) 127 patients had ≥1 hospitalisation. The event rate of new DU per person-year was 0.66, of DU-associated complications was 0.10, and of surgical or diagnostic procedures was 0.12. At the prospective visit, patients with ≥1 DU reported impairment in daily activities by 57%, those with 0 DU by 37%. The mean difference between patients with or without DU in the SF-36 physical component was 2.2, and in the mental component 1.4. DU patients were not routinely prescribed endothelin receptor antagonists or prostanoids. This real world cohort demonstrates that DU require hospital admission, and impair daily activity. PAH and multiple DU at diagnosis were associated with future occurrence of DU.

  13. Cancer du sein bilatéral synchrone au Maroc: caractéristiques épidémiologiques et cliniques

    PubMed Central

    Boufettal, Houssine; Samouh, Naïma

    2015-01-01

    Préciser la fréquence, les facteurs de risque et le pronostic du cancer du sein bilatéral, à partir d'une étude rétrospective de 22 cas de cancer du sein bilatéral synchrone dans un pays du Maghreb. De 2002 à 2010, 625 patientes étaient prises en charge pour cancer du sein au service de Gynécologie-Obstétrique «C» du centre hospitalier universitaire de Casablanca. 22 cas de cancer bilatéral synchrone étaient diagnostiqués. Nos résultats sont comparés avec ceux de la littérature. La fréquence de la bilatéralité du cancer du sein synchrone était de 3,52% (22/625). L'intervalle de temps moyen entre les deux cancers est de 4 mois (0 à 6 mois). Les patientes âgées de moins de 40 ans lors du premier cancer avaient six fois plus de risque de développer un cancer au niveau du sein controlatéral que les femmes âgées de plus de 40 ans. Les patientes atteintes d'une tumeur T3 ou T4 avaient un risque neuf fois plus élevé que les autres. 90,9% (2/22) des cas des premiers cancers sont des adénocarcinomes infiltrants. Les types histologiques du premier et du douzième cancer étaient identiques dans 86,4% (19/22) des cas. Quant au pronostic, il dépend à la fois du stade du premier et du deuxième cancer et le traitement de ce dernier doit obéir aux mêmes règles du traitement du premier cancer. L'incidence du cancer bilatéral synchrone du sein est de 3,52% dans notre série. Le cancer du sein unilatéral constitue un facteur de risque de développement d'un cancer du sein controlatéral. Une surveillance à vie est nécessaire au cours d'un cancer du sein pour détecter un cancer controlatéral. PMID:26090066

  14. The Evolution of Depleted Uranium as an Environmental Risk Factor: Lessons from Other Metals

    PubMed Central

    Briner, Wayne E.

    2006-01-01

    Depleted uranium (DU) is used in both civilian and military applications. Civilian uses are primarily limited to ballast and counterweights in ships and aircraft with limited risk of environmental release. The very nature of the military use of DU releases DU into the environment. DU released into the environment from military use takes the form of large fragments that are chemically unchanged and dust in the form of oxides. DU dust is nearly insoluble, respirable and shows little mobility in the soil. Exposure to DU occurs primarily from inhalation of dust and possible hand to mouth activity. Toxicity of DU is believed to be primarily chemical in nature with radiological activity being a lesser problem. DU has been shown to have a variety of behavioral and neurological effects in experimental animals. DU has been used the Balkans, Afghanistan, and both Iraq wars and there is a high probability of its use in future conflicts. Further, other nations are developing DU weaponry; some of these nations may use DU with a greater radiological risk than those currently in use. The toxicity of DU has been studied mostly as an issue of the health of military personnel. However, many tons of DU have been left in the former theater of war and indigenous populations continue to be exposed to DU, primarily in the form of dust. Little epidemiological data exists concerning the impact of DU on these groups. It may be possible to extrapolate what the effects of DU may be on indigenous groups by examining the data on similar metals. DU has many similarities to lead in its route of exposure, chemistry, metabolic fate, target organs, and effect of experimental animals. Studies should be conducted on indigenous groups using lead as a model when ascertaining if DU has an adverse effect. PMID:16823086

  15. Corrections corner

    NASA Astrophysics Data System (ADS)

    Miller, Arthur I.; Shanklin, Jon

    2015-09-01

    In your otherwise informative article on “Curing the Curie complex” (Features, August pp25-28), you wrote “Albert Einstein was awarded a Nobel prize for his discovery of the photoelectric effect”.

  16. Presidential Green Chemistry Challenge: 2012 Small Business Award

    EPA Pesticide Factsheets

    Presidential Green Chemistry Challenge 2012 award winner, Elevance Renewable Sciences, used Nobel-prize-winning metathesis catalysis to produce high-value difunctional chemicals from renewable feedstocks including natural oils.

  17. The 2009 Nobel Prize in Chemistry: Thomas A. Steitz and the structure of the ribosome.

    PubMed

    Zhao, Peter

    2011-06-01

    Over the past 200 years, there have been countless groundbreaking discoveries in biology and medicine at Yale University. However, one particularly noteworthy discovery with profoundly important and broad consequences happened here in just the past two decades. In 2009, Thomas Steitz, the Sterling Professor of Molecular Biophysics & Biochemistry, was awarded the Nobel Prize in Chemistry for "studies of the structure and function of the ribosome," along with Venkatraman Ramakrishnan of the MRC Laboratory of Molecular Biology and Ada E. Yonath of the Weizmann Institute of Science. This article covers the historical context of Steitz's important discovery, the techniques his laboratory used to study the ribosome, and the impact that this research has had, and will have, on the future of biological and medical research.

  18. Superfund Record of Decision (EPA Region 5): Bofors Nobel Site, Muskegon, MI. (First remedial action), (amendment), July 1992. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    The 85-acre Bofors Nobel site contains an active specialty chemical production plant in Egelston Township, Muskegon County, Michigan. Site features include an unused landfill. The ROD amends a 1990 ROD written by the state, which consisted of onsite incineration and onsite landfilling of lagoon area soil, construction of RCRA-type secure landfill cells to hold non-incinerated material and ash from the incinerated sludge. The selected amended remedial action for the site includes excavating and containing approximately 767,000 cubic yards of untreated sludge and soil in onsite RCRA-type secure landfill cells constructed as part of the original remedial action. The ROD Amendmentmore » does not address any issue associated with ground water treatment.« less

  19. Nobel Prize Recipient Eric Betzig Presents Lecture on Efforts to Improve High-Resolution Microscopy | Poster

    Cancer.gov

    Eric Betzig, Ph.D., a 2014 recipient of the Nobel Prize in Chemistry and a scientist at Janelia Research Campus (JRC), Howard Hughes Medical Institute, in Ashburn, Va., visited NCI at Frederick on Sept. 10 to present a Distinguished Scientist lecture and discuss the latest high-resolution microscopy techniques. Betzig co-invented photoactivation localization microscopy (PALM) in collaboration with scientists at NIH. PALM achieves 10-fold improvement in spatial resolution of cells, going from the resolution limit of approximately 250 nm in standard optical microscopy down to approximately 20 nm, thus producing a so-called “super-resolution” image. Spatial resolution refers to the clarity of an image or, in other words, the smallest details that can be observed from an image.

  20. Science Underlying 2008 Nobel Prizes

    NASA Astrophysics Data System (ADS)

    Caldwell, Bernadette A.

    2009-01-01

    JCE offers a wealth of materials for teaching and learning chemistry that you can explore online. In the list below, Bernadette Caldwell of the Editorial Staff suggests additional resources that are available through JCE for teaching the science behind some of the 2008 Nobel Prizes . Discovering and Applying the Chemistry of GFP The Royal Swedish Academy of Sciences awarded the 2008 Nobel Prize in Chemistry for the discovery and development of the green fluorescent protein, GFP to three scientists: Osamu Shimomura, Martin Chalfie, and Roger Y. Tsien. These scientists led the field in discovering and introducing a fluorescing protein from jellyfish into cells and genes under study, which allows researchers to witness biochemistry in action. Now tags are available that emit light in different colors, revealing myriad biological processes and their interactions simultaneously. Identifying HPV and HIV, HIV's Replication Cycle, and HIV Virus-Host Interactions The Nobel Assembly at Karolinska Institutet awarded the 2008 Nobel Prize in Medicine or Physiology for their discovery of human immunodeficiency virus (HIV) to two scientists: Françoise Barré-Sinoussi and Luc Montagnier; and for his discovery of human papilloma viruses [HPV] causing cervical cancer to one scientist, Harald zur Hausen. Diseases caused by these infectious agents significantly affect global health. While isolating and studying the virus, researchers discovered HIV is an uncommon retrovirus that infects humans and relies on the host to make its viral DNA, infecting and killing the host's white blood cells, ultimately destroying the immune systems of infected humans. Related Resources at JCE Online The Journal has published articles relating to GFP specifically, and more generally to fluorescing compounds applied to biochemistry. The Journal has also published an article and a video on protease inhibition—a strategy to suppress HIV's biological processes. With the video clips, an accompanying guide for teachers includes instructions for three student activities that use enzymes. The resources below may help introduce students to the science behind some of these Nobel Prizes. Turning on the Light: Lessons from Luminescence. O'Hara, P. B.; Engelson, C.; St. Peter, W. J. Chem. Educ. 2005, 82, 49 . (See especially the bioluminescence section on page 51 that concisely explains GFP.) JCE Classroom Activity #68: Turning on the Light. O'Hara, P. B.; Engelson, C.; St. Peter, W. J. Chem. Educ. 2005, 82, 48A . JCE Classroom Activity #81: pHantastic Fluorescence. Muyskens, M. J. Chem. Educ. 2006, 83, 768A . Recombinant Green Fluorescent Protein Isoforms: Exercises To Integrate Molecular Biology, Biochemistry, and Biophysical Chemistry. Hicks, B. W. J. Chem. Educ. 1999, 76, 409 . C-SNARF-1 as a Fluorescent Probe for pH Measurements in Living Cells: Two-Wavelength-Ratio Method versus Whole-Spectral-Resolution Method. Ribou, A-C.; Vigo, J.; Salmon, J-M. J. Chem. Educ. 2002, 79, 1471 . An Attack on the AIDS Virus: Inhibition of the HIV-1 Protease: New Drug Development Based on the Structure and Activity of the Protease and Its Role in the Replication and Maturation of the Virus. Volker, E. J. J. Chem. Educ. 1993, 70, 3 . From Chemistry Comes Alive!, five video clips demonstrate properties and mechanisms involved in the chemistry of HIV. HIV-1 Protease: An Enzyme at Work . All articles from Volume 1 to the current issue are available in full-text PDF at JCE Online : Browse by year, month, and page , or choose title and author searching of all issues of JCE.

  1. Vitamin B1

    MedlinePlus

    ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Quick Facts Nomination Nomination Physics Prize Chemistry ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Nomination Archive Ceremonies Ceremonies Ceremony Archive Nobel ...

  2. Traumatismes fermés et pénétrants de l'abdomen: analyse rétrospective sur 175 cas et revue de la littérature

    PubMed Central

    Fanomezantsoa, Raherinantenaina; Davidà, Rakotomena Solonirina; Tianarivelo, Rajaonarivony; Fabienne, Rabetsiahiny Lalao; Aina, Rajaonanahary Toky Mamin'Ny; Auberlin, Rakototiana Felantsoa; Allen, Hunald Francis; Nirina, Rakoto Ratsimba Hery

    2015-01-01

    Les traumatismes abdominaux sont relativement fréquents mais graves dans les pays en développement. Le but de cette étude était de décrire les aspects épidémiologiques, diagnostiques, thérapeutiques et évolutifs des contusions et plaies pénétrantes de l'abdomen prises en charge dans un pays à faibles ressources. Patients et méthodes: Il s'agissait d'une étude rétrospective et descriptive de 2 ans (2011-2012) ayant colligé 175 cas de traumatisés abdominaux au CHU-JRA Tananarive Madagascar. Parmi ces blessés (144 hommes et 31 femmes), il existait 122 vivants (69,7%) et 53 décès (30,3%) avant tout geste thérapeutique hospitalier. Les étiologies étaient dominées par les accidents à responsabilité civile (52,5%) et de la voie publique (38,5%). Les contusions et plaies pénétrantes représentaient respectivement 41,8% et 58,2%. Parmi les blessés vivants, 112 ont été opérés (91,8%). L’évolution hospitalière était favorable dans 94,3%. Quatre patients avaient des suites opératoires compliquées (3,6%). Sept patients étaient décédés (5,7%). Parmi les décès préhospitaliers, nous avons observé 73,6% de polytraumatisme (n = 39) et 26,4% de traumatismes abdominaux isolés (n = 14). A l'autopsie, les lésions abdominales étaient hémorragiques dans 94,3% incluant des plaies vasculaires rétropéritonéales, des ruptures hépatospléniques et des traumatismes graves du bassin. En situation précaire, les traumatismes abdominaux ont une mortalité préhospitalière assez importante. A l'hôpital, l’évolution était généralement favorable au prix d'un acte opératoire invasif. PMID:26097633

  3. Depleted uranium induces neoplastic transformation in human lung epithelial cells.

    PubMed

    Xie, Hong; LaCerte, Carolyne; Thompson, W Douglas; Wise, John Pierce

    2010-02-15

    Depleted uranium (DU) is commonly used in military armor and munitions, and thus, exposure of soldiers and noncombatants is frequent and widespread. Previous studies have shown that DU has both chemical and radiological toxicity and that the primary route of exposure of DU to humans is through inhalation and ingestion. However, there is limited research information on the potential carcinogenicity of DU in human bronchial cells. Accordingly, we determined the neoplastic transforming ability of particulate DU to human bronchial epithelial cells (BEP2D). We observed the loss of contact inhibition and anchorage independent growth in cells exposed to DU after 24 h. We also characterized these DU-induced transformed cell lines and found that 40% of the cell lines exhibit alterations in plating efficiency and no significant changes in the cytotoxic response to DU. Cytogenetic analyses showed that 53% of the DU-transformed cell lines possess a hypodiploid phenotype. These data indicate that human bronchial cells are transformed by DU and exhibit significant chromosome instability consistent with a neoplastic phenotype.

  4. Play the Mosquito Game

    MedlinePlus

    ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Quick Facts Nomination Nomination Physics Prize Chemistry ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Nomination Archive Ceremonies Ceremonies Ceremony Archive Nobel ...

  5. Play the MRI Game

    MedlinePlus

    ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Quick Facts Nomination Nomination Physics Prize Chemistry ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Nomination Archive Ceremonies Ceremonies Ceremony Archive Nobel ...

  6. Play the Tuberculosis Game

    MedlinePlus

    ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Quick Facts Nomination Nomination Physics Prize Chemistry ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Nomination Archive Ceremonies Ceremonies Ceremony Archive Nobel ...

  7. Play the Electrocardiogram Game

    MedlinePlus

    ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Quick Facts Nomination Nomination Physics Prize Chemistry ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Nomination Archive Ceremonies Ceremonies Ceremony Archive Nobel ...

  8. An examination of past and present influences on university chemistry education

    NASA Astrophysics Data System (ADS)

    Soliman, William Atef

    This study examined the historical influences that have contributed to past and present-day university level chemistry education. The study was organized into three sections: First, by analyzing the academic genealogy, education origins of prominent chemists, Nobel Prize winners in chemistry and scientific patents awarded by countries; the major historical contributors to chemical education during the 19th century were identified; Secondly, by analyzing the educational backgrounds of current chemistry professors (n=12,120) in 407 universities in 40 countries around the world and six chemical education indicators for 25 countries; and finally the relationship, if any, between a country's chemical, biotechnology, defense, and petroleum industries to its level of chemistry education was investigated utilizing a multiple regression analysis between the monetary value of the industries and the extent of chemical education within each country. The findings indicated that the U.S., Britain, Germany, and France were major influencers of 19th century chemical education while the major present-day influencers of university chemical education are the U.S., Germany, Britain, France, Italy, and Japan. Pearson correlation coefficients indicated that the value of the chemical industry for a country was significantly related to (a) the number of chemistry doctorates awarded (p=.05), (b) chemistry Nobel awards (p=.001), (c) the number of chemistry publications (p=.001), and (d) prominence of the country in the chemical literature (p=.05). Multiple regression analysis indicated that the value of the biotechnology industry was significantly related to the number of Nobel awards (p=.007) and the number of chemistry publications (p=.001). The value of the defense industry was significantly related to chemistry doctorates (p=.002), chemistry Nobel awards (p=.001), the number of chemistry publications (p=.001), and prominence in the literature (p=.001). The value of the petroleum industry was not significantly related to any education variables. The findings suggest that university chemical education is influenced by a select group of countries and that chemical, biotechnology, and defense industry values are significantly related to the level of a country's chemical education. These findings may be valuable to those interested in the industrial and societal applications of chemical education.

  9. The impact of homologous recombination repair deficiency on depleted uranium clastogenicity in Chinese hamster ovary cells: XRCC3 protects cells from chromosome aberrations, but increases chromosome fragmentation.

    PubMed

    Holmes, Amie L; Joyce, Kellie; Xie, Hong; Falank, Carolyne; Hinz, John M; Wise, John Pierce

    2014-04-01

    Depleted uranium (DU) is extensively used in both industry and military applications. The potential for civilian and military personnel exposure to DU is rising, but there are limited data on the potential health hazards of DU exposure. Previous laboratory research indicates DU is a potential carcinogen, but epidemiological studies remain inconclusive. DU is genotoxic, inducing DNA double strand breaks, chromosome damage and mutations, but the mechanisms of genotoxicity or repair pathways involved in protecting cells against DU-induced damage remain unknown. The purpose of this study was to investigate the effects of homologous recombination repair deficiency on DU-induced genotoxicity using RAD51D and XRCC3-deficient Chinese hamster ovary (CHO) cell lines. Cells deficient in XRCC3 (irs1SF) exhibited similar cytotoxicity after DU exposure compared to wild-type (AA8) and XRCC3-complemented (1SFwt8) cells, but DU induced more break-type and fusion-type lesions in XRCC3-deficient cells compared to wild-type and XRCC3-complemented cells. Surprisingly, loss of RAD51D did not affect DU-induced cytotoxicity or genotoxicity. DU induced selective X-chromosome fragmentation irrespective of RAD51D status, but loss of XRCC3 nearly eliminated fragmentation observed after DU exposure in wild-type and XRCC3-complemented cells. Thus, XRCC3, but not RAD51D, protects cells from DU-induced breaks and fusions and also plays a role in DU-induced chromosome fragmentation. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Consequences experimentales des effets des fluctuations du vide sur la fluorescence parametrique et la generation du second harmonique en milieu confine

    NASA Astrophysics Data System (ADS)

    Robichaud, Luc

    Les fluctuations du vide, qui consistent en l'apparition momentanee de particules, ce qui est permit par le principe d'incertitude de Heisenberg, joue un role primordial dans les processus photoniques, en particulier les processus non-lineaires. Par la manipulation de ces fluctuations du vide a l'aide de confinement optique, on retrouve deux phenomenes particuliers : l'intensification de la fluorescence parametrique (Walker, 2008) et l'inhibition de la generation du second harmonique (Collette, 2013). Dans ce travail, on presente les resultats dans le cas classique ; c'est-a-dire sans fluctuations du vide et confinement. Par la suite, on presente les effets des fluctuations du vide et du confinement, ce qui mene aux deux effets mentionnes. Dans le cas de la fluorescence parametrique, le bruit quantique sur le champ interne et externe est calcule, le role du desaccord de phase dans le modele est expose et une generalisation tridimensionnelle est etudiee afin de generaliser la conception du modele d'un cas unidimensionnel a un cas tridimensionnel planaire. Dans le cas de la generation du second harmonique, les difficultes d'un modele purement tridimensionnel sont exposees et ensuite le cas limite planaire est etudie.

  11. What Happens during Prenatal Visits?

    MedlinePlus

    ... Snapshot of Adult & Family Health Advances NICHD Nobel Prize Winners Leadership & Other Staff Profiles Leadership Biosketches Get ... health care providers won't schedule a visit any earlier unless you have a medical condition, have ...

  12. Play the Blood Typing Game

    MedlinePlus

    ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Quick Facts Nomination Nomination Physics Prize Chemistry ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Nomination Archive Ceremonies Ceremonies Ceremony Archive Nobel ...

  13. Universal Truths.

    ERIC Educational Resources Information Center

    Horgan, John

    1990-01-01

    Described is a symposium of Nobel laureates held in the summer of 1990 to discuss cosmology. Different views on the structure and evolution of the universe are presented. Evidence for different theories of cosmology is discussed. (CW)

  14. ARC-2007-ACD07-0189-018

    NASA Image and Video Library

    2007-10-02

    International Space Station (ISS) National Laboratory Workshop L-R Lynn Harper, Ames and Baruch Blumberg, Nobel Laureate, Fox Chase Cancer Center during talk on Science on the international Space Station, Past and Future.

  15. An alternative for cost-effective remediation of depleted uranium (DU) at certain environmental restoration sites.

    PubMed

    Miller, M; Galloway, B; VanDerpoel, G; Johnson, E; Copland, J; Salazar, M

    2000-02-01

    Numerous sites in the United States and around the world are contaminated with depleted uranium (DU) in various forms. A prevalent form is fragmented DU originating from various scientific tests involving high explosives and DU during weapon development programs, at firing practice ranges, or war theaters where DU was used in armor-piercing projectiles. The contamination at these sites is typically very heterogeneous, with discreet, visually identifiable DU fragments mixed with native soil. That is, the bulk-averaged DU activity is quite low, while specific DU fragments, which are distinct from the soil matrix, have much higher specific activity. DU is best known as a dark, black metal that is nearly twice as dense as lead, but DU in the environment readily weathers (oxidizes) to a distinctive bright yellow color that is readily visible. While the specific activity (amount of radioactivity per mass of soil) of DU is relatively low and presents only a minor radiological hazard, the fact that it is radioactive and visually identifiable makes it desirable to remove the DU "contamination" from the environment. The typical approach to conducting this DU remediation is to use radiation detection instruments to identify the contaminant and separate it from the adjacent soil, packaging it for disposal as radioactive waste. This process can be performed manually or by specialized, automated equipment. Alternatively, in certain situations a more cost-effective approach might be simple mechanical or gravimetric separation of the DU fragments from the host soil matrix. At SNL/NM, both the automated and simple mechanical approaches have recently been employed. This paper discusses the pros/cons of the two approaches.

  16. Cirque du Monde en tant qu’intervention en santé

    PubMed Central

    Fournier, Cynthia; Drouin, Mélodie-Anne; Marcoux, Jérémie; Garel, Patricia; Bochud, Emmanuel; Théberge, Julie; Aubertin, Patrice; Favreau, Gil; Fleet, Richard

    2014-01-01

    Résumé Objectif Présenter le programme Cirque du Monde du Cirque du Soleil et son potentiel en tant qu’intervention en soins de santé de première ligne pour les médecins de famille. Sources des données Une revue de la littérature menée dans les bases de données PubMed, Cochrane Library, PsycINFO, La Presse, Eureka, Google Scholar et Érudit à l’aide des mots-clés circus, social circus, Cirque du Monde et Cirque du Soleil. Une initiative à Montréal nommée Espace Transition qui s’inspire directement de Cirque du Monde. Communication personnelle avec le conseiller principal en formation en cirque social du Cirque du Soleil. Sélection d’études Les 50 premiers articles ou sites Internet répertoriés pour chaque mot-clé dans chacune des bases de données ciblées ont été révisés sur la base des titres et des résumés, s’il s’agissait d’un article, ou sur la base du titre et du contenu de la page, s’il s’agissait d’une page Internet. Ensuite, les articles et les sites Internet qui étudiaient un aspect du cirque social ou qui présentaient une intervention impliquant le cirque étaient retenus pour une révision. Aucune contrainte d’année de publication n’a été appliquée étant donné qu’on cherchait une littérature générale sur le cirque social. Synthèse Aucun article n’a été trouvé sur le cirque social en tant qu’intervention en santé. Nous avons trouvé une étude sur l’utilisation du cirque en tant qu’intervention en milieu scolaire. Cette étude a démontré une augmentation de l’estime personnelle des enfants grâce à l’intervention. Nous avons trouvé une étude sur l’utilisation du cirque en tant qu’intervention sur une réserve amérindienne. Cette étude présente des résultats qualitatifs non spécifiques au programme du cirque social. Les autres articles répertoriés n’étaient que des descriptions du cirque social. Un site web concernant l’utilisation du cirque social pour faciliter la réintégration sociale de jeunes traités en milieu hospitalier pour un trouble psychiatrique majeur a été répertorié. L’équipe du département de pédopsychiatrie du Centre hospitalier universitaire Sainte-Justine responsable de ce projet nommé Espace Transition a été contactée. Des résultats préliminaires non publiés du projet pilote montrent des améliorations significatives du fonctionnement général des patients. Selon le Cirque du Soleil, plusieurs projets de recherche portant sur l’impact thérapeutique du cirque social sont en cours à travers le monde. Conclusion Cirque du Monde rejoint une clientèle marginalisée difficilement accessible par le système de santé. Ce programme revêt un potentiel thérapeutique de par sa clientèle cible, sa promotion de saines habitudes de vie et le soutien qu’il offre par l’intermédiaire du groupe et des intervenants. Compte tenu des investissements financiers importants du Cirque du Soleil dans ce projet, le manque de littérature donnant accès à des données probantes constitue un enjeu important.

  17. Depleted uranium contamination by inhalation exposure and its detection after approximately 20 years: implications for human health assessment.

    PubMed

    Parrish, Randall R; Horstwood, Matthew; Arnason, John G; Chenery, Simon; Brewer, Tim; Lloyd, Nicholas S; Carpenter, David O

    2008-02-01

    Inhaled depleted uranium (DU) aerosols are recognised as a distinct human health hazard and DU has been suggested to be responsible in part for illness in both military and civilian populations that may have been exposed. This study aimed to develop and use a testing procedure capable of detecting an individual's historic milligram-quantity aerosol exposure to DU up to 20 years after the event. This method was applied to individuals associated with or living proximal to a DU munitions plant in Colonie New York that were likely to have had a significant DU aerosol inhalation exposure, in order to improve DU-exposure screening reliability and gain insight into the residence time of DU in humans. We show using sensitive mass spectrometric techniques that when exposure to aerosol has been unambiguous and in sufficient quantity, urinary excretion of DU can be detected more than 20 years after primary DU inhalation contamination ceased, even when DU constitutes only approximately 1% of the total excreted uranium. It seems reasonable to conclude that a chronically DU-exposed population exists within the contamination 'footprint' of the munitions plant in Colonie, New York. The method allows even a modest DU exposure to be identified where other less sensitive methods would have failed entirely. This should allow better assessment of historical exposure incidence than currently exists.

  18. Play the Immune System Defender Game

    MedlinePlus

    ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Quick Facts Nomination Nomination Physics Prize Chemistry ... Medicine Prize Literature Prize Peace Prize Prize in Economic Sciences Nomination Archive Ceremonies Ceremonies Ceremony Archive Nobel ...

  19. Fisher Center for Alzheimer's Research Foundation

    MedlinePlus

    ... We are making a major impact on Alzheimer’s research. Our scientific discoveries are featured in top publications ... is vetted by scientists for accuracy. Explore Our Research Nobel Prize Winner Dr. Paul Greengard leads our ...

  20. Hepatitis B Foundation Newsletter: B Informed

    MedlinePlus

    ... CDC Awards Hepatitis B Foundation 5-Year Cooperative Agreement It Takes a Coalition to Fight Hepatitis B ... Dr. Baruch S. Blumberg HBF Awarded 3-Year Cooperative Agreement from CDC About "A Nobel Challenge" Cure Agenda ...

  1. GSFC_20170308_2017-8679_041

    NASA Image and Video Library

    2017-03-08

    Lt. Governor Rutherford and staff visited Goddard on March 8, 2017. They toured James Webb Space Telescope with Bill Ochs and Robotics Operations Center with Ben Reed. They also met John Mather, Nobel Prize winner.

  2. How Are Newborn Screening Tests Done?

    MedlinePlus

    ... Health Advances NICHD Nobel Prize Winners Leadership & Other Staff Profiles Leadership Biosketches Get to Know NICHD Budget & ... Listservs About NICHD Organization History Accomplishments Leadership & Other Staff Profiles Budget & Appropriations Advisory Groups Jobs at NICHD ...

  3. GSFC_20170308_2017-8679_036

    NASA Image and Video Library

    2017-03-08

    Lt. Governor Rutherford and staff visited Goddard on March 8, 2017. They toured James Webb Space Telescope with Bill Ochs and Robotic Operations Center with Ben Reed. They also met John Mather, Nobel Prize winner.

  4. GSFC_20170308_2017-8679_015

    NASA Image and Video Library

    2017-03-08

    Lt. Governor Rutherford and staff visited Goddard on March 8, 2017. They toured James Webb Space Telescope with Bill Ochs and Robotic Operations Center with Ben Reed. They also met John Mather, Nobel Prize winner.

  5. Featured Image | Galaxy of Images

    Science.gov Websites

    our most popular images is that of renowned female scientist (and the first recipient of two Nobel cameras as the perfect way to capture summer memories. This adventurous female copilot attempts to

  6. Chlorinated hydrocarbon insecticides

    USGS Publications Warehouse

    Friend, M.; Franson, J.C.

    1999-01-01

    Chlorinated hydrocarbon insecticides (OCs) are diverse synthetic chemicals that belong to several groups, based on chemical structure. DDT is the best known of these insecticides. First synthesized in 1874, DDT remained obscure until its insecticidal properties became known in 1939, a discovery that earned a Nobel Prize in 1948. The means of synthesizing the cyclodiene group, the most toxic of the OCs, was discovered in 1928 and resulted in a Nobel Prize in 1950. The insecticidal properties of cyclodienes, which include aldrin, dieldrin, and endrin (Table 40.1), were discovered about 1945. OCs became widely used in the United States following World War II. Their primary uses included broad spectrum applications for agricultural crops and forestry and, to a lesser extent, human health protection by spraying to destroy mosquitoes and other potential disease carriers. These compounds also became widely used to combat insect carriers of domestic animal diseases.

  7. Pavlov and Cajal: Two different pathways to a Nobel Prize.

    PubMed

    Rozo, Jairo A; Andrade-Talavera, Yuniesky; Rodríguez-Moreno, Antonio

    2017-01-01

    Ivan Pavlov (1849-1936) and Santiago Ramón y Cajal (1852-1934) were two contemporary scientists who not only had a great impact on Russian and Spanish science but also on the international stage. Both shared several common features in their life and work, yet they followed fundamentally different paths during their training as scientists. While Pavlov received his laboratory training under the guidance of Ilya Tsion (1843-1912), Cajal did not receive any formal training within a particular laboratory nor did he have a mentor in the traditional sense, rather he was mainly self-taught, although he was supported by key figures like Maestre de San Juan (1828-1890) and Luis Simarro (1851-1921). In this article, we compare the scientific training of these two Nobel Prize laureates and the influences they received during their scientific lives.

  8. Approche de prise en charge du trouble du spectre de l’autisme

    PubMed Central

    Lee, Patrick F.; Thomas, Roger E.; Lee, Patricia A.

    2015-01-01

    Résumé Objectif Se pencher sur les critères diagnostiques du trouble du spectre de l’autisme (TSA) comme les définit le Manuel diagnostique et statistique des troubles mentaux, cinquième édition (DSM-V), et concevoir une approche de prise en charge du TSA à l’aide du cadre CanMEDS–Médecine familiale (CanMEDS-MF). Sources d’information Le DSM-V, publié par l’American Psychiatric Association en mai 2013, énonce de nouveaux critères diagnostiques du TSA. Le cadre CanMEDS-MF du Collège des médecins de famille du Canada fournit un plan d’orientation pour la prise en charge complexe du TSA. Nous avons utilisé des données recueillies par le Centers for Disease Control and Prevention afin de déterminer la prévalence du TSA, ainsi que la revue systématique et méta-analyse détaillée effectuée par le National Institute for Health and Care Excellence du R.-U. pour ses lignes directrices sur le TSA dans le but d’évaluer les données probantes issues de plus de 100 interventions. Message principal Selon les données du Centers for Disease Control and Prevention, la prévalence du TSA se chiffrait à 1 sur 88 en 2008 aux États-Unis. La classification du TSA dans la quatrième édition du DSM incluait l’autisme, le syndrome d’Asperger, le trouble envahissant du développement et le trouble désintégratif de l’enfance. La dernière révision du DSM-V réunit tous ces troubles sous la mention TSA, avec différents niveaux de sévérité. La prise en charge du TSA est complexe; elle exige les efforts d’une équipe multidisciplinaire ainsi que des soins continus. Les rôles CanMEDS-MF fournissent un cadre de prise en charge. Conclusion Les médecins de famille sont au cœur de l’équipe de soins multidisciplinaire pour le TSA, et le cadre CanMEDS-MF tient lieu de plan détaillé pour guider la prise en charge d’un enfant atteint de TSA et aider la famille de cet enfant.

  9. Methodology for Assessing Disruptions (MAD) Game Part I: Report and Analysis

    DTIC Science & Technology

    2012-12-01

    élaborées dans le Guide de planification fonctionnelle du groupe du SMA(S& T ). Le présent mémorandum technique est principalement destiné au Bureau du...le Guide de planification fonctionnelle du groupe du SMA(S& T ). Le présent mémorandum technique est principalement destiné au Bureau du scientifique en...2010 2012-009 Principal Author Original signed by G . Adlakha-Hutcheon, M. Hazen, P. Hubbard, S. McLelland, K. Sprague G . Adlakha

  10. Participation des médecins généralistes de la province de Benimellal (Maroc) dans le dépistage du cancer du col

    PubMed Central

    Nani, Samira; Benallal, Mohamed; Hassoune, Samira; Kissi, Dounia; Maaroufi, Abderrahmane

    2013-01-01

    Introduction Au Maroc, chaque année il y aurait environ 2000 nouveaux cas de cancer du col et les 2/3 des cas sont pris en charge à un stade très avancé. Nous avons mené une étude transversale, exhaustive incluant les 71 médecins généralistes exerçant dans les établissements de soins de santé de base du secteur public et privé de la province de Benimellal. Le but était d’évaluer leurs connaissances et leur participation au dépistage du cancer du col. Méthodes Nous avons mené une étude transversale, exhaustive incluant les 71 médecins généralistes exerçant dans les établissements de soins de santé de base du secteur public et privé de la province de Benimellal. Le but était d’évaluer leurs connaissances et leur participation au dépistage du cancer du col. Résultats Le niveau de connaissance était relativement modeste, 22 médecins généraliste avaient répondu à la question sur l'incidence du cancer du col au Maroc, Parmi eux (81,8%) avaient donné une réponse incorrecte. L'Herpes Papilloma virus comme facteur de risque du cancer du col a été identifié par seulement 21% des médecins généralistes. La participation au dépistage était également défaillante, 92,8% n'avaient jamais pratiqué le FCV chez leurs patientes à cause principalement du manque de formation (95,5%). Conclusion Les résultats montrent la nécessité d'améliorer les connaissances théoriques et pratique des médecins généralistes concernant le dépistage du cancer du col. PMID:23785557

  11. A Review of Depleted Uranium Biological Effects: In vivo Studies

    DTIC Science & Technology

    2010-11-01

    organs - Uranium retention is long-term - DU causes some neurotoxicity - DU induces genotoxicity - DU urine is mutagenic - DU causes adverse oncogene...Behavior; Locomotor Brain Accumulation Sperm Effects Immune Effects Offspring Effects Behavior Yes Yes Yes No effects Decreased Inflammatory...in Unexposed Offspring Finding: DU Internalized Exposure Induces Germ Cell DNA Damage Uranium Distribution Behavior Neurobio Histopathology Sperm

  12. Non-destructive analysis of DU content in the NIF hohlraums

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gharibyan, Narek; Moody, Ken J.; Shaughnessy, Dawn A.

    2015-12-16

    The advantage of using depleted uranium (DU) hohlraums in high-yield deuterium-tritium (DT) shots at the National Ignition Facility (NIF) is addressed by Döppner, et al., in great detail [1]. This DU based hohlraum incorporates a thin layer of DU, ~7 μm thick, on the inner surface along with a thin layer of a gold coating, ~0.7 μm thick, while the outer layer is ~22 μm thick gold. A thickness measurement of the DU layer can be performed using an optical microscope where the total DU weight can be computed provided a uniform DU layer. However, the uniformity of the thicknessmore » is not constant throughout the hohlraum since CAD drawing calculations of the DU weight do not agree with the computed values from optical measurements [2]. Therefore, a non-destructive method for quantifying the DU content in hohlraums has been established by utilizing gamma-ray spectroscopy. The details of this method, along with results from several hohlraums, are presented in this report.« less

  13. Metallographic Characterization of Wrought Depleted Uranium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Forsyth, Robert Thomas; Hill, Mary Ann

    Metallographic characterization was performed on wrought depleted uranium (DU) samples taken from the longitudinal and transverse orientations from specific locations on two specimens. Characterization of the samples included general microstructure, inclusion analysis, grain size analysis, and microhardness testing. Comparisons of the characterization results were made to determine any differences based on specimen, sample orientation, or sample location. In addition, the characterization results for the wrought DU samples were also compared with data obtained from the metallographic characterization of cast DU samples previously characterized. No differences were observed in microstructure, inclusion size, morphology, and distribution, or grain size in regard tomore » specimen, location, or orientation for the wrought depleted uranium samples. However, a small difference was observed in average hardness with regard to orientation at the same locations within the same specimen. The longitudinal samples were slightly harder than the transverse samples from the same location of the same specimen. This was true for both wrought DU specimens. Comparing the wrought DU sample data with the previously characterized cast DU sample data, distinct differences in microstructure, inclusion size, morphology and distribution, grain size, and microhardness were observed. As expected, the microstructure of the wrought DU samples consisted of small recrystallized grains which were uniform, randomly oriented, and equiaxed with minimal twinning observed in only a few grains. In contrast, the cast DU microstructure consisted of large irregularly shaped grains with extensive twinning observed in most grains. Inclusions in the wrought DU samples were elongated, broken and cracked and light and dark phases were observed in some inclusions. The mean inclusion area percentage for the wrought DU samples ranged from 0.08% to 0.34% and the average density from all wrought DU samples was 1.62E+04/cm 2. Inclusions in the cast DU samples were equiaxed and intact with light and dark phases observed in some inclusions. The mean inclusion area percentage for the cast DU samples ranged from 0.93% to 1.00% and the average density from all wrought DU samples was 2.83E+04/cm 2. The average mean grain area from all wrought DU samples was 141 μm 2 while the average mean grain area from all cast DU samples was 1.7 mm2. The average Knoop microhardness from all wrought DU samples was 215 HK and the average Knoop microhardness from all cast DU samples was 264 HK.« less

  14. The Early Antiproton Work [Nobel Lecture

    DOE R&D Accomplishments Database

    Chamberlain, O.

    1959-12-15

    Early work on the antiproton, particularly that part which led to the first paper on the subject, is described. Conclusions that can be drawn purely from the existence of the antiproton are discussed. (W.D.M.)

  15. Marie Curie's Doctoral Thesis: Prelude to a Nobel Prize.

    ERIC Educational Resources Information Center

    Wolke, Robert L.

    1988-01-01

    Traces the life and research techniques of Marie Curie's doctoral dissertation leading to the discovery and purification of radium from ore. Reexamines the discoveries of other scientists that helped lead to this separation. (ML)

  16. Smoot Cosmology Group

    Science.gov Websites

    Nobel Prize for physics. He led a team that mapped the early universe, revealing its primal form and the said these fifteen billion-year-old fossils are the primordial seeds that grew into the galaxies and

  17. Martin Karplus and Computer Modeling for Chemical Systems

    Science.gov Websites

    &D Nuggets Database dropdown arrow Search Tag Cloud Browse Reports Database Help Finding Aids with two-time Nobel laureate Linus Pauling, whom Karplus described as an important early influence. He

  18. The International Science and Politics of Depleted Uranium (Briefing charts)

    DTIC Science & Technology

    2010-11-01

    lied before …” • Cite each other’s websites • Uniqueness: “DU + Anthrax Vaccine + Diet Soda + Flea Collars + Stress = Gulf War Illness • Demand proving...Activist Quotes • “DU was used in Iraq, Soldiers were in Iraq, Soldiers are sick, DU made the soldiers sick” • “DU is more dangerous than natural uranium...1 atom of DU will kill you” • “DU is more dangerous the further you are from the source” • “Depleted uranium is nuclear waste” • “U.S. is using

  19. Connaissances des médecins généralistes de Mohammedia (Maroc) concernant le dépistage du cancer du sein

    PubMed Central

    Zine, Karima; Nani, Samira; Lahmadi, Imad Ait; Maaroufi, Abderrahmane

    2016-01-01

    Introduction Le cancer du sein représente un problème de santé publique majeur au Maroc. C'est le premier cancer chez la femme. L'objectif de ce travail était d'évaluer les connaissances des médecins généralistes (MG) en matière de dépistage du cancer du sein dans la préfecture de Mohammedia Maroc. Méthodes Nous avons mené une étude transversale, descriptive, exhaustive incluant les 97 MG exerçant dans les établissements de soins de santé de base du secteur public et privé de la province de Mohammedia. Résultats Le taux de participation était de 87%. L'âge moyen des MG était de 49,6 ± 8,1. Quatre-vingt pour cent (n=55) des MG ont donné une incidence incorrecte, 77,6% (n=85) ont reconnu l'existence d'un plan national de prévention et de contrôle du cancer (PNPCC) au Maroc, et 67,1 des MG ont rapporté l'existence d'un registre du cancer au Maroc. Le secteur d'activité était associé significativement avec les connaissances des MG sur le PNPCC et sur l'existence d'un guide de détection précoce du cancer du sein avec respectivement (p=0,003 et p=0,001). Une association significative entre l'ancienneté et l'existence d'un guide de détection précoce du cancer du sein et d'un registre du cancer du sein a été retrouvée avec (respectivement p=0,005 et p=0.002). Conclusion À la lumière de ces résultats il faudra renforcer les connaissances et les pratiques des MG par la promotion de la formation initiale et continue sur le dépistage. PMID:27800098

  20. Depleted and natural uranium: chemistry and toxicological effects.

    PubMed

    Craft, Elena; Abu-Qare, Aquel; Flaherty, Meghan; Garofolo, Melissa; Rincavage, Heather; Abou-Donia, Mohamed

    2004-01-01

    Depleted uranium (DU) is a by-product from the chemical enrichment of naturally occurring uranium. Natural uranium is comprised of three radioactive isotopes: (238)U, (235)U, and (234)U. This enrichment process reduces the radioactivity of DU to roughly 30% of that of natural uranium. Nonmilitary uses of DU include counterweights in airplanes, shields against radiation in medical radiotherapy units and transport of radioactive isotopes. DU has also been used during wartime in heavy tank armor, armor-piercing bullets, and missiles, due to its desirable chemical properties coupled with its decreased radioactivity. DU weapons are used unreservedly by the armed forces. Chemically and toxicologically, DU behaves similarly to natural uranium metal. Although the effects of DU on human health are not easily discerned, they may be produced by both its chemical and radiological properties. DU can be toxic to many bodily systems, as presented in this review. Most importantly, normal functioning of the kidney, brain, liver, and heart can be affected by DU exposure. Numerous other systems can also be affected by DU exposure, and these are also reviewed. Despite the prevalence of DU usage in many applications, limited data exist regarding the toxicological consequences on human health. This review focuses on the chemistry, pharmacokinetics, and toxicological effects of depleted and natural uranium on several systems in the mammalian body. A section on risk assessment concludes the review.

  1. Ghrelin protects against depleted uranium-induced apoptosis of MC3T3-E1 cells through oxidative stress-mediated p38-mitogen-activated protein kinase pathway

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hao, Yuhui; Liu, Cong; Huang, Jiawei

    Depleted uranium (DU) mainly accumulates in the bone over the long term. Osteoblast cells are responsible for the formation of bone, and they are sensitive to DU damage. However, studies investigating methods of reducing DU damage in osteoblasts are rarely reported. Ghrelin is a stomach hormone that stimulates growth hormones released from the hypothalamic–pituitary axis, and it is believed to play an important physiological role in bone metabolism. This study evaluates the impact of ghrelin on DU-induced apoptosis of the osteoblast MC3T3-E1 and investigates its underlying mechanisms. The results show that ghrelin relieved the intracellular oxidative stress induced by DU,more » eliminated reactive oxygen species (ROS) and reduced lipid peroxidation by increasing intracellular GSH levels; in addition, ghrelin effectively suppressed apoptosis, enhanced mitochondrial membrane potential, and inhibited cytochrome c release and caspase-3 activation after DU exposure. Moreover, ghrelin significantly reduced the expression of DU-induced phosphorylated p38-mitogen-activated protein kinase (MAPK). A specific inhibitor (SB203580) or specific siRNA of p38-MAPK could significantly suppress DU-induced apoptosis and related signals, whereas ROS production was not affected. In addition, ghrelin receptor inhibition could reduce the anti-apoptosis effect of ghrelin on DU and reverse the effect of ghrelin on intracellular ROS and p38-MAPK after DU exposure. These results suggest that ghrelin can suppress DU-induced apoptosis of MC3T3-E1 cells, reduce DU-induced oxidative stress by interacting with its receptor, and inhibit downstream p38-MAPK activation, thereby suppressing the mitochondrial-dependent apoptosis pathway. - Highlights: • Ghrelin suppressed DU-induced apoptosis of MC3T3-E1 cells. • Ghrelin inhibited DU-induced oxidative stress and further p38-MAPK activation. • Ghrelin further suppressed mitochondrial-dependent apoptosis pathway. • The anti-oxidation effect of ghrelin was regulated through its receptor. • Ghrelin has the potential for use in drug therapies for DU poisoning.« less

  2. Depleted and enriched uranium exposure quantified in former factory workers and local residents of NL Industries, Colonie, NY USA.

    PubMed

    Arnason, John G; Pellegri, Christine N; Moore, June L; Lewis-Michl, Elizabeth L; Parsons, Patrick J

    2016-10-01

    Between 1958 and 1982, NL Industries manufactured components of enriched (EU) and depleted uranium (DU) at a factory in Colonie NY, USA. More than 5 metric tons of DU was deposited as microscopic DU oxide particles on the plant site and surrounding residential community. A prior study involving a small number of individuals (n=23) indicated some residents were exposed to DU and former workers to both DU and EU, most probably through inhalation of aerosol particles. Our aim was to measure total uranium [U] and the uranium isotope ratios: (234)U/(238)U; (235)U/(238)U; and (236)U/(238)U, in the urine of a cohort of former workers and nearby residents of the NLI factory, to characterize individual exposure to natural uranium (NU), DU, and EU more than 3 decades after production ceased. We conducted a biomonitoring study in a larger cohort of 32 former workers and 99 residents, who may have been exposed during its period of operation, by measuring Total U, NU, DU, and EU in urine using Sector Field Inductively Coupled Plasma - Mass Spectrometry (SF-ICP-MS). Among workers, 84% were exposed to DU, 9% to EU and DU, and 6% to natural uranium (NU) only. For those exposed to DU, urinary isotopic and [U] compositions result from binary mixing of NU and the DU plant feedstock. Among residents, 8% show evidence of DU exposure, whereas none shows evidence of EU exposure. For residents, the [U] geometric mean is significantly below the value reported for NHANES. There is no significant difference in [U] between exposed and unexposed residents, suggesting that [U] alone is not a reliable indicator of exposure to DU in this group. Ninety four percent of workers tested showed evidence of exposure to DU, EU or both, and were still excreting DU and EU decades after leaving the workforce. The study demonstrates the advantage of measuring multiple isotopic ratios (e.g., (236)U/(238)U and (235)U/(238)U) over a single ratio ((235)U/(238)U) in determining sources of uranium exposure. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. The EJ Curriculum Catalog: A Directory of Units and Electives

    ERIC Educational Resources Information Center

    Koch, Susan, comp.

    1977-01-01

    Describes fourteen innovative high school English units dealing with such subjects as literature (e.g., "Nobel Prize Winning World Literature,""The Eskimo and His Literature," and "Women's Literature"), the mass media, and Greek mythology. (DD)

  4. Roger D. Kornberg Polymerase, DNA, RNA, and Transcription

    Science.gov Websites

    D. Kornberg was awarded the 2006 Nobel Prize in Chemistry "for his studies of the molecular transcription works at a molecular level in the important group of organisms called eukaryotes (organisms whose

  5. Looking Back on Books and Other Guides.

    ERIC Educational Resources Information Center

    Anderson, Carl D.

    1981-01-01

    Presents 11 responses received from U.S. scientists who have won Nobel Prizes (physics or physics-related work) indicating what books, discoveries, people, or issues of the last 50 years have most decisively influenced them. (Author/JN)

  6. [From the Scrapie syndrome of sheep and goat to the mad cow disease - the history of the discovery of prion].

    PubMed

    Liu, Rui; Weng, Yi

    2009-05-01

    Since the discovery of Scrapie Syndrome in sheep and goats in 1730, there emerged a series of diseases such as Creutzfeldt-Jakob disease, kuru disease and mad cow disease etc. In the research of kuru disease, the American scientist D. Carlteton Gajdusek found a new virus without the characteristic of DNA and RNA, which was awarded the Nobel Prize in physiology in 1976. Since then another American scientist, Stanley B. Prusiner, found a new virus-prion, taking protein as the genetic medium, which was awarded the Nobel prize in physiology and medicine in 1997. The discovery of prion is a great landmark in the research of life science, which laid a theoretical foundation for people to conquer a series of diseases such as Scrapie syndrome in sheep and goats, Creutzfeldt-Jakob disease, kuru disease and mad cow disease etc.

  7. Magnetocapacitance and the physics of solid state interfaces

    NASA Astrophysics Data System (ADS)

    Hebard, Arthur

    2008-10-01

    When Herbert Kroemer stated in his Nobel address [1] that ``the interface is the device,'' he was implicitly acknowledging the importance of understanding the physics of interfaces. If interfaces are to have character traits, then ``impedance'' (or complex capacitance) would be a commonly used descriptor. In this talk I will discuss the use of magnetic fields to probe the ``character'' of a variety of interfaces including planar capacitor structures with magnetic electrodes, simple metal/semiconductor contacts (Schottky barriers) and the interface-dominated competition on microscopic length scales between ferromagnetic metallic and charge-ordered insulating phases in complex oxides. I will show that seeking experimental answers to surprisingly simple questions often leads to striking results that seriously challenge theoretical understanding. Perhaps Herbert Kroemer should have said, ``the interface is the device with a magnetic personality that continually surprises.'' [3pt] [1] Herbert Kroemer, ``Quasielectric fields and band offsets: teaching electron s new tricks,'' Nobel Lecture, December 8, 2000:

  8. Nobel prize winner trading card (CIRCA 1952). Elie Metchnikoff.

    PubMed

    Hammerschmidt, Dale E

    2003-03-01

    Russian doctor and bacteriologist, born in Ivanowca in 1845. He began his studies in Kharkov, continuing them at the Universities of Giessen, Gothingen, and Munich, later being named Professor of Zoology in Odessa in 1870. In the Canary Islands, he completed some anthropological works, but dedicated himself especially to studies of marine fauna. In 1887, much taken by the work of Pasteur, he wrote to him asking for a position in his laboratories; in a short time he became one of the principal collaborators with the master, especially in works concerning bacteriology. These were an inspiration to him, and led him to his famous theory of phagocytosis, the defensive act whereby white blood cells protect an organism against pathogenic microbes. Metchnikoff supposed that old age was avoidable, and subscribed to the materialistic school of thought. He was awarded the Nobel Prize in 1908. (With the complements of the Jose Lopez Luis Cigarillo Factory, Tenerife).

  9. Mrs. Chandrasekhar addresses the media in TRW Media Hospitality Tent

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Mrs. Lalitha Chandrasekhar (at podium), wife of the late Indian- American Nobel Laureate Subrahmanyan Chandrasekhar, addresses the media and other invited guests in the TRW Media Hospitality Tent at the NASA Press Site at KSC. Other participants in the program (seated facing the audience, left to right) are the winners of the contest to rename the telescope, Jatila van der Veen, academic coordinator and lecturer, Physics Dept., University of Santa Barbara, Calif., and Tyrel Johnson, high school student, Laclede, Idaho; Joanne Maguire, vice-president and general manager, TRW Space & Laser Programs Division; and Dr. Alan Bunner, Science Program Director, Structure and Evolution of the Universe, Office of Space Science, NASA Headquarters, Washington, D.C. The name 'Chandra,' a shortened version of Chandrasekhar, was the name the Nobel Laureate preferred among friends and colleagues. 'Chandra' also means 'Moon' or 'luminous' in Sanskrit. The observatory is scheduled to be launched aboard Columbia on Space Shuttle mission STS-93.

  10. The Basel Institute for Immunology.

    PubMed

    Melchers, Fritz

    2012-01-01

    At the Centennial Exhibition of the Nobel Prize, the Nobel Foundation called it one of the ten cradles of creativity. The journal Nature likened its ideals to those of the French revolution--Liberté, Egalité, Fraternité--and called it a paradise devoted to the science of immune systems: the Basel Institute for Immunology (BII). Founded by Roche in 1968, inaugurated in 1971, and closed in 2000, it was home to almost 450 scientific members, over 1,000 scientific visitors, and nearly 100 scientific advisors from more than 30 countries who worked in complete academic freedom and without commercial motives on over 3,500 projects, publishing more than 3,200 scientific papers, almost all of them on the structure and functions of immune systems of different species. This review contains a first collection of historical facts and dates that describe the background of the exceptionally successful performance and the strong scientific impact of the institute on the field of immunology.

  11. How molecular motors work – insights from the molecular machinist's toolbox: the Nobel prize in Chemistry 2016

    PubMed Central

    Astumian, R. D.

    2017-01-01

    The Nobel prize in Chemistry for 2016 was awarded to Jean Pierre Sauvage, Sir James Fraser Stoddart, and Bernard (Ben) Feringa for their contributions to the design and synthesis of molecular machines. While this field is still in its infancy, and at present there are no commercial applications, many observers have stressed the tremendous potential of molecular machines to revolutionize technology. However, perhaps the most important result so far accruing from the synthesis of molecular machines is the insight provided into the fundamental mechanisms by which molecular motors, including biological motors such as kinesin, myosin, FoF1 ATPase, and the flagellar motor, function. The ability to “tinker” with separate components of molecular motors allows asking, and answering, specific questions about mechanism, particularly with regard to light driven vs. chemistry driven molecular motors. PMID:28572896

  12. Julius Wagner-Jauregg and the Legacy of Malarial Therapy for the Treatment of General Paresis of the Insane

    PubMed Central

    Tsay, Cynthia J.

    2013-01-01

    Julius Wagner-Jauregg, a preeminent Austrian psychiatrist was awarded the Nobel Prize in Medicine in 1927 for the development of malaria therapy for the treatment of neurosyphilis, or general paresis of the insane. Despite being only one of three psychiatrists to win a Nobel Prize, he has faded from public consciousness and his name recognition pales in comparison to his contemporary and fellow Austrian, Sigmund Freud. This paper explores his contributions to the field of biological psychiatry and also touches upon reasons, such as the growing bioethics movement, his controversial affiliation with the Nazi Party, and the evolution of neurosyphilis, that explain why Wagner-Jauregg is not more widely celebrated for his contributions to the field of psychiatry, even though his malarial treatment could be considered the earliest triumph of biological psychiatry over psychoanalysis. PMID:23766744

  13. KSC-99pp0978

    NASA Image and Video Library

    1999-07-19

    Mrs. Lalitha Chandrasekhar (at podium), wife of the late Indian-American Nobel Laureate Subrahmanyan Chandrasekhar, addresses the media and other invited guests in the TRW Media Hospitality Tent at the NASA Press Site at KSC. Other participants in the program (seated facing the audience, left to right) are the winners of the contest to rename the telescope, Jatila van der Veen, academic coordinator and lecturer, Physics Dept., University of Santa Barbara, Calif., and Tyrel Johnson, high school student, Laclede, Idaho; Joanne Maguire, vice-president and general manager, TRW Space & Laser Programs Division; and Dr. Alan Bunner, Science Program Director, Structure and Evolution of the Universe, Office of Space Science, NASA Headquarters, Washington, D.C. The name "Chandra," a shortened version of Chandrasekhar, was the name the Nobel Laureate preferred among friends and colleagues. "Chandra" also means "Moon" or "luminous" in Sanskrit. The observatory is scheduled to be launched aboard Columbia on Space Shuttle mission STS-93

  14. The 2015 Nobel Prize in Chemistry The Discovery of Essential Mechanisms that Repair DNA Damage.

    PubMed

    Lindahl, Tomas; Modrich, Paul; Sancar, Aziz

    2016-01-01

    The Royal Swedish Academy awarded the Nobel Prize in Chemistry for 2015 to Tomas Lindahl, Paul Modrich and Aziz Sancar for their discoveries in fundamental mechanisms of DNA repair. This pioneering research described three different essential pathways that correct DNA damage, safeguard the integrity of the genetic code to ensure its accurate replication through generations, and allow proper cell division. Working independently of each other, Tomas Lindahl, Paul Modrich and Aziz Sancar delineated the mechanisms of base excision repair, mismatch repair and nucleotide excision repair, respectively. These breakthroughs challenged and dismissed the early view that the DNA molecule was very stable, paving the way for the discovery of human hereditary diseases associated with distinct DNA repair deficiencies and a susceptibility to cancer. It also brought a deeper understanding of cancer as well as neurodegenerative or neurological diseases, and let to novel strategies to treat cancer.

  15. Depleted and enriched uranium exposure quantified in former factory workers and local residents of NL Industries, Colonie, NY USA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Arnason, John G.

    Background: Between 1958 and 1982, NL Industries manufactured components of enriched (EU) and depleted uranium (DU) at a factory in Colonie NY, USA. More than 5 metric tons of DU was deposited as microscopic DU oxide particles on the plant site and surrounding residential community. A prior study involving a small number of individuals (n=23) indicated some residents were exposed to DU and former workers to both DU and EU, most probably through inhalation of aerosol particles. Objectives: Our aim was to measure total uranium [U] and the uranium isotope ratios: {sup 234}U/{sup 238}U; {sup 235}U/{sup 238}U; and {sup 236}U/{supmore » 238}U, in the urine of a cohort of former workers and nearby residents of the NLI factory, to characterize individual exposure to natural uranium (NU), DU, and EU more than 3 decades after production ceased. Methods: We conducted a biomonitoring study in a larger cohort of 32 former workers and 99 residents, who may have been exposed during its period of operation, by measuring Total U, NU, DU, and EU in urine using Sector Field Inductively Coupled Plasma - Mass Spectrometry (SF-ICP-MS). Results: Among workers, 84% were exposed to DU, 9% to EU and DU, and 6% to natural uranium (NU) only. For those exposed to DU, urinary isotopic and [U] compositions result from binary mixing of NU and the DU plant feedstock. Among residents, 8% show evidence of DU exposure, whereas none shows evidence of EU exposure. For residents, the [U] geometric mean is significantly below the value reported for NHANES. There is no significant difference in [U] between exposed and unexposed residents, suggesting that [U] alone is not a reliable indicator of exposure to DU in this group. Conclusions: Ninety four percent of workers tested showed evidence of exposure to DU, EU or both, and were still excreting DU and EU decades after leaving the workforce. The study demonstrates the advantage of measuring multiple isotopic ratios (e.g., {sup 236}U/{sup 238}U and {sup 235}U/{sup 238}U) over a single ratio ({sup 235}U/{sup 238}U) in determining sources of uranium exposure. - Highlights: • Biomonitoring study of residents and former workers exposed to DU in Colonie NY. • Urine (99 residents+32 former workers) analyzed for depleted uranium (DU). • DU detected in 84% of workers and 8% of residents >30 years after plant closed. • Enriched uranium detected in 6% of former workers based on isotope ratios.« less

  16. Neurogenic Causes of Detrusor Underactivity

    PubMed Central

    Kadow, Brian T.; Tyagi, Pradeep; Chermansky, Christopher J.

    2015-01-01

    Detrusor underactivity (DU) is a poorly understood dysfunction of the lower urinary tract which arises from multiple etiologies. Symptoms of DU are non-specific, and a pressure-flow urodynamic study is necessary to differentiate DU from other conditions such as overactive bladder (OAB) or bladder outlet obstruction (BOO). The prevalence of DU ranges from 10–48%, and DU is most prevalent in elderly males. The pathophysiology underlying DU can be from both neurogenic and non-neurogenic causes. In this article, we review the neurogenic causes of detrusor underactivity, including diabetic bladder dysfunction, spinal cord injury, multiple sclerosis, Parkinson’s disease, cerebrovascular accident, traumatic brain injury, and Fowler’s syndrome. As knowledge about the underlying causes of DU advances, there have been several potential therapeutic approaches proposed to help those who suffer from this condition. PMID:26715948

  17. Rupture simultanée du ligament croisé antérieur et du ligament patellaire: à propos d'un cas

    PubMed Central

    Achkoun, Abdessalam; Houjairi, Khalid; Quahtan, Omar; Hassoun, Jalal; Arssi, Mohamed; Rahmi, Mohamed; Garch, Abdelhak

    2016-01-01

    La rupture simultanée du tendon rotulien et du ligament croisé antérieur est une lésion relativement rare. Son diagnostic peut facilement manquer lors de l'examen initial. Les options de traitement incluent la réparation immédiate du tendon rotulien avec soit la reconstruction simultanée ou différée de ligament croisé antérieur. Nous rapportons le cas d'une rupture combinée du tendon rotulien et du ligament croisé antérieur chez un jeune footballeur de 22 ans. Une approche de traitement en deux temps a été effectuée avec un excellent résultat fonctionnel. PMID:27366288

  18. ^1H NMR studies of the diamagnetic gallium (III) and paramagnetic iron (III) complexes of a chiral macrobicyclic ligand of bicapped tris (binaphtol) type

    NASA Astrophysics Data System (ADS)

    Baret, P.; Beaujolais, V.; Bougault, C.; Gaude, D.; Pierre, J.-L.

    1998-01-01

    ^1H NMR studies of the diamagnetic gallium (III) and paramagnetic iron (III) complexes of a chiral macrobicyclic ligand of bicapped tris (binaphtol) type are described. The study of the gallium complex emphasizes: (i) that the inversion of the octahedral center is not observed and: (ii) the absence of exchange between free ligand and complex, at room temperature. In the case of the iron complex, assignments of the hyperfine shifted resolved resonances are achieved, based on temperature-behavior studies, which evidence the D3 symmetry of the complex. These assignments are in complete agreement with measured T1 values and proton-to-iron distances obtained from molecular modelling. Les complexes du gallium (III) et du fer (III) d'un ligand macrobicyclique chiral impliquant trois sous-unités de type binaphtol sont étudiés en RMN du proton en solution méthanolique. L'étude du complexe (diamagnétique) du gallium permet de montrer que le complexe : (i) ne subit pas d'inversion de la configuration (Δ/Λ) du site octaédrique et : (ii) qu'il n'y a pas d'échange entre ligand libre et complexe à la température ambiante. L'évolution du spectre du complexe paramagnétique du fer avec la température permet une attribution des protons du ligand et met en évidence la symétrie D3 du complexe. Une bonne corrélation est obtenue entre la distance fer-proton (donnée par la modélisation moléculaire) et le T1 du proton considéré.

  19. Dynamic Testing of Signal Transduction Deregulation During Breast Cancer Initiation

    DTIC Science & Technology

    2012-07-01

    Std. Z39.18 Victoria Seewaldt, M.D. Dynamic Testing of Signal Transduction Deregulation During Breast Cancer Initiation Duke University Durham...attomole- zeptomole range. Internal dilution curves insure a high-dynamic calibration range. DU -26 8L DU -26 6L DU -29 5R DU -22 9.2 L DU...3: Nanobiosensor technology is translated to test for pathway deregulation in RPFNA cytology obtained from 10 high-risk women with cytological

  20. How Citation Boosts Promote Scientific Paradigm Shifts and Nobel Prizes

    PubMed Central

    Mazloumian, Amin; Eom, Young-Ho; Helbing, Dirk; Lozano, Sergi; Fortunato, Santo

    2011-01-01

    Nobel Prizes are commonly seen to be among the most prestigious achievements of our times. Based on mining several million citations, we quantitatively analyze the processes driving paradigm shifts in science. We find that groundbreaking discoveries of Nobel Prize Laureates and other famous scientists are not only acknowledged by many citations of their landmark papers. Surprisingly, they also boost the citation rates of their previous publications. Given that innovations must outcompete the rich-gets-richer effect for scientific citations, it turns out that they can make their way only through citation cascades. A quantitative analysis reveals how and why they happen. Science appears to behave like a self-organized critical system, in which citation cascades of all sizes occur, from continuous scientific progress all the way up to scientific revolutions, which change the way we see our world. Measuring the “boosting effect” of landmark papers, our analysis reveals how new ideas and new players can make their way and finally triumph in a world dominated by established paradigms. The underlying “boost factor” is also useful to discover scientific breakthroughs and talents much earlier than through classical citation analysis, which by now has become a widespread method to measure scientific excellence, influencing scientific careers and the distribution of research funds. Our findings reveal patterns of collective social behavior, which are also interesting from an attention economics perspective. Understanding the origin of scientific authority may therefore ultimately help to explain how social influence comes about and why the value of goods depends so strongly on the attention they attract. PMID:21573229

  1. How citation boosts promote scientific paradigm shifts and nobel prizes.

    PubMed

    Mazloumian, Amin; Eom, Young-Ho; Helbing, Dirk; Lozano, Sergi; Fortunato, Santo

    2011-05-04

    Nobel Prizes are commonly seen to be among the most prestigious achievements of our times. Based on mining several million citations, we quantitatively analyze the processes driving paradigm shifts in science. We find that groundbreaking discoveries of Nobel Prize Laureates and other famous scientists are not only acknowledged by many citations of their landmark papers. Surprisingly, they also boost the citation rates of their previous publications. Given that innovations must outcompete the rich-gets-richer effect for scientific citations, it turns out that they can make their way only through citation cascades. A quantitative analysis reveals how and why they happen. Science appears to behave like a self-organized critical system, in which citation cascades of all sizes occur, from continuous scientific progress all the way up to scientific revolutions, which change the way we see our world. Measuring the "boosting effect" of landmark papers, our analysis reveals how new ideas and new players can make their way and finally triumph in a world dominated by established paradigms. The underlying "boost factor" is also useful to discover scientific breakthroughs and talents much earlier than through classical citation analysis, which by now has become a widespread method to measure scientific excellence, influencing scientific careers and the distribution of research funds. Our findings reveal patterns of collective social behavior, which are also interesting from an attention economics perspective. Understanding the origin of scientific authority may therefore ultimately help to explain how social influence comes about and why the value of goods depends so strongly on the attention they attract.

  2. An interview with Nobel laureate Roy Glauber, Physics 2005.

    PubMed

    Glauber, Roy

    2009-06-26

    The field of quantum optics rests on the work of Roy Glauber, who helped elucidate the nature of light as both particles and waves. According to Glauber, quantum optics allowed "all sorts of experiments...that never could have been done before." He suggests that it was not his "small revelation" that the Nobel Committee awarded, but rather the decades of research that followed his own. Nonetheless, Glauber received one-half of the 2005 Nobel Prize in Physics "for his contribution to the quantum theory of optical coherence" while the other half was shared by John Hall and Theodor Hänsch for their work on laser-based precision spectroscopy. Glauber admits that the behavior of light seems strange and unintuitive--yet the phenomena that Einstein called "spooky action at a distance" may have many practical applications. In this candid interview, Glauber shares his thoughts about working at Los Alamos National Laboratory--his shock to learn that he was helping to build The Bomb, and his dismay about how it was used. At Los Alamos, Glauber met two of his major influences: Julian Schwinger, who was Glauber's thesis advisor at Harvard, and Los Alamos scientific director Robert Oppenheimer, who facilitated his early post-doctoral research. Glauber also tells a poignant account of how his marriage fell victim to the social upheaval of the 1960's, and how he was left to raise two children alone. Despite the difficulties of reconciling academia with family, Glauber is amused to find himself revered by women as "someone who has raised children and nonetheless had a successful academic career."

  3. Biomechanical evaluation of one-piece and two-piece small-diameter dental implants: In-vitro experimental and three-dimensional finite element analyses.

    PubMed

    Wu, Aaron Yu-Jen; Hsu, Jui-Ting; Chee, Winston; Lin, Yun-Te; Fuh, Lih-Jyh; Huang, Heng-Li

    2016-09-01

    Small-diameter dental implants are associated with a higher risk of implant failure. This study used both three-dimensional finite-element (FE) simulations and in-vitro experimental tests to analyze the stresses and strains in both the implant and the surrounding bone when using one-piece (NobelDirect) and two-piece (NobelReplace) small-diameter implants, with the aim of understanding the underlying biomechanical mechanisms. Six experimental artificial jawbone models and two FE models were prepared for one-piece and two-piece 3.5-mm diameter implants. Rosette strain gauges were used for in-vitro tests, with peak values of the principal bone strain recorded with a data acquisition system. Implant stability as quantified by Periotest values (PTV) were also recorded for both types of implants. Experimental data were analyzed statistically using Wilcoxon's rank-sum test. In FE simulations, the peak value and distribution of von-Mises stresses in the implant and bone were selected for evaluation. In in-vitro tests, the peak bone strain was 42% lower for two-piece implants than for one-piece implants. The PTV was slightly lower for one-piece implants (PTV = -6) than for two-piece implants (PTV = -5). In FE simulations, the stresses in the bone and implant were about 23% higher and 12% lower, respectively, for one-piece implants than those for two-piece implants. Due to the higher peri-implant bone stresses and strains, one-piece implants (NobelDirect) might be not suitable for use as small-diameter implants. Copyright © 2016. Published by Elsevier B.V.

  4. Hazardous Waste Cleanup: E.I. DuPont de Nemours & Company in Pompton Lakes, New Jersey

    EPA Pesticide Factsheets

    E.I. DuPont De Nemours & Company is located at 2000 Cannonball Road, Pompton Lakes, New Jersey. The DuPont Pompton Lakes Works site (DuPont) occupies approximately 570 acres of land in Pompton Lakes and Wanaque.

  5. Metallothionein deficiency aggravates depleted uranium-induced nephrotoxicity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hao, Yuhui; Huang, Jiawei; Gu, Ying

    Depleted uranium (DU) has been widely used in both civilian and military activities, and the kidney is the main target organ of DU during acute high-dose exposures. In this study, the nephrotoxicity caused by DU in metallothionein-1/2-null mice (MT −/−) and corresponding wild-type (MT +/+) mice was investigated to determine any associations with MT. Each MT −/− or MT +/+ mouse was pretreated with a single dose of DU (10 mg/kg, intraperitoneal injection) or an equivalent volume of saline. After 4 days of DU administration, kidney changes were assessed. After DU exposure, serum creatinine and serum urea nitrogen in MTmore » −/− mice significantly increased than in MT +/+ mice, with more severe kidney pathological damage. Moreover, catalase and superoxide dismutase (SOD) decreased, and generation of reactive oxygen species and malondialdehyde increased in MT −/− mice. The apoptosis rate in MT −/− mice significantly increased, with a significant increase in both Bax and caspase 3 and a decrease in Bcl-2. Furthermore, sodium-glucose cotransporter (SGLT) and sodium-phosphate cotransporter (NaPi-II) were significantly reduced after DU exposure, and the change of SGLT was more evident in MT −/− mice. Finally, exogenous MT was used to evaluate the correlation between kidney changes induced by DU and MT doses in MT −/− mice. The results showed that, the pathological damage and cell apoptosis decreased, and SOD and SGLT levels increased with increasing dose of MT. In conclusion, MT deficiency aggravated DU-induced nephrotoxicity, and the molecular mechanisms appeared to be related to the increased oxidative stress and apoptosis, and decreased SGLT expression. - Highlights: • MT −/− and MT +/+ mice were used to evaluate nephrotoxicity of DU. • Renal damage was more evident in the MT −/− mice after exposure to DU. • Exogenous MT also protects against DU-induced nephrotoxicity. • MT deficiency induced more ROS and apoptosis after exposure to DU. • MT deficiency down-regulated SGLT expression after exposure to DU.« less

  6. Identification des objets et detection de leur alignement en utilisant la technologie RFID

    NASA Astrophysics Data System (ADS)

    Rahma, Zayoud

    De nos jours, les vehicules motorises sont essentiels dans notre vie quotidienne, d'ou la necessite de leur approvisionnement en carburant. L'approvisionnement en carburant peut entrainer certains inconvenients, tels que: les files d'attente, la disponibilite non-continuelle du carburant et les fraudes. Les problemes d'attente et de disponibilite non-continuelle du carburant peuvent etre facilement resolus en allant a une autre station d'essence aux alentours si disponibles. Par contre le probleme de fraudes est plus difficile a resoudre. De ce fait, decoule notre solution qui consiste a developper un systeme intelligent pour la gestion d'approvisionnement en carburant afin de remedier a ce probleme de fraudes. Pour des raisons de surete, il faut eviter les risques d'etincelles dans l'environnement du carburant. En particulier, il convient de ne pas utiliser un systeme utilisant 1'electricite proche de la pompe, du tuyau ou du reservoir du carburant du vehicule. Nous avons choisi la technologie RFID (Radio Frequency IDentification) et avons opte pour l'utilisation des etiquettes passives, etant donne que les etiquettes semi-passives ou actives contiennent une batterie electrique et sont nettement plus cheres. Un vehicule motorise sera identifie avec une etiquette RFID passive collee au-dessus du goulot de son reservoir. Deux autres etiquettes RFID seront placees sur le pistolet de sorte que le flux du carburant ne sera autorise que lorsque les trois etiquettes sont alignees. Notre travail etait a la demande d'une entreprise petroliere ayant une chaine internationale de stations de carburant. Le travail consiste en la conception, par la recherche, du systeme requis et s'articule sur l'optimisation de la topologie des antennes et des etiquettes de sorte que le systeme juge qu'il y a alignement lorsque le bec du pistolet est fonce dans le goulot du reservoir, et par consequent autorise le versement du carburant. Dans tous les autres cas, le systeme doit juger qu'il n'y a pas alignement et par consequent le flux du carburant n'est pas autorise. Mots cles: RFID, identification, localisation, alignement, fraudes, station-service.

  7. Selection for fertility in mice - the selection plateau and how to overcome it.

    PubMed

    Schüler, L

    1985-04-01

    A long-term experiment for increasing the traits first day litter size (LS1) and litter weight (LW1) was conducted with two populations for 33 generations. The selection plateau was reached in population DU-C (selection and estrus synchronization (h(2) = 0.02±0.01); in population DU-K (selection) the plateau (h(2) = 0.05±0.2) was nearly reached. Selection progress per generation was in LS1 b = 0.11±0.02; b = 0.12±0.04 (1st to 18th generation DU-K, DU-C) and b = 0.10±0.03; b = 0.07±0.05 (19th to 33rd generation, DU-K, DU-C) in LW1 b = 0.16±0.04 g; 0.19±0.07 g (DU-K, DU-C) b = 0.20±0.09 g; 0.001±0.09 g (DU-K, DU-C). Reverse and relaxe selection as well as systematic inbreeding was applied for 10 generations. Reverse selection yielded h(2) = 0.28±0.11 (R-DU-K) and h(2) = 0.17±0.05 (R-DU-C) and showed that there was still additive genetic variance. Relaxe selection did not cause alterations in the selection parameters, whereas inbreeding lead to inbred depressions (b = LS1 = -0.42±0.15; -0.45±0.12; b = LW1 = -1.13±0.20; -0.82±0.18 I-DU-K, I-DU-C). The plateau was based upon the heterozygote advantage. Several methods for overcoming the plateau were applied. A new selective useful variance could be created by crossing the plateau populations (h(2) = 0.14±0.04). A short-term progress in overcoming the plateau (1st to 3rd generation) could be obtained by litter size standardization (LS = 388). Tandem selection (selection for body weight - BW42) as well as crossing of inbred strains were not suitable for overcoming the selection plateau. Altering the environmental conditions as a possibility for overcoming the plateau has been discussed.

  8. Beyond Themselves: Students Work for Human Rights.

    ERIC Educational Resources Information Center

    Mayher, William S.

    1985-01-01

    How students and teachers in a private secondary school started a chapter of Amnesty International, the international human rights organization that received the 1977 Nobel Prize for Peace, is described. The many positive results of the experience are discussed. (RM)

  9. George Hoyt Whipple and the Impact of Liver on Anemia

    Science.gov Websites

    Nobel Prize for his discovery that liver fed to anemic dogs reverses the effects of the anemia. This Effects of Ionizing Radiation Cycle, DOE Technical Report, 1952 Top Additional Web Pages: George H

  10. JILA BEC/Ultracold Atoms Homepage

    Science.gov Websites

    JILA BEC & Ultracold Atoms Bose Einstein Condensate Eric Cornell Cornell Group Debbie Jin Jin Group Jun Ye Ye Group Dana Anderson Anderson Group What is BEC? Easy BEC Machine Nobel BEC BibTek Papers

  11. The Year in Science.

    ERIC Educational Resources Information Center

    Discover, 1983

    1983-01-01

    Highlights major accomplishments, developments, and research in the sciences during 1982, focusing on the space sciences, astronomy, medicine, biology, psychology, chemistry, physics, environment, and zoology. Includes a brief statement of the 1982 Nobel Prize winners' research in medicine, chemistry, and physics. (JN)

  12. A Conversation about Observation

    NASA Technical Reports Server (NTRS)

    Mather, John C.; Mao, Minnie Yuan

    2012-01-01

    In the spirit of the Lindau Meeting, we present a dialogue between a Nobel laureate and a young researcher. This interchange started online, where it continues to unfold. Here is a digest of this conversation, which has developed across time and space.

  13. Prevalence of duck circovirus infection of subclinical pekin ducks in South Korea.

    PubMed

    Cha, Se-Yeoun; Song, Eu-Tteum; Kang, Min; Wei, Bai; Seo, Hye-Suk; Roh, Jae-Hee; Yoon, Ran-Hee; Moon, Oun-Kyoung; Jang, Hyung-Kwan

    2014-04-01

    An investigation was carried out to determine the prevalence and infection pattern of duck circovirus (DuCV) in subclinical Pekin ducks on South Korean duck farms. A total of 147 samples collected from 92 duck farms in five provinces were examined from 2011 to 2012. The overall prevalence of DuCV PCR-positive pooled bursa of Fabricius and liver samples was 21.8% (32/147). The prevalence of DuCV PCR-positive samples increased significantly in 3-week-old ducks compared with that in 1-week-old ducks (P<0.05). DuCV in association with Riemerella and Salmonella infections (10.9%; 16/147) occurred at the same level as infection with DuCV alone (10.9%; 16/147). In comparison of the relationship between bacterial diseases (salmonellosis, Riemerella infection) and morbidity in farms with and without DuCV, morbidity was higher in circovirus-positive farms (50%; 16/32) than in circovirus-negative farms (26.1%; 30/115). Our findings provide baseline information on the degree of DuCV infection and distribution and pattern of DuCV in ducks, and it is evident that DuCV can be associated with subclinical diseases and that subclinical infection could be economically important.

  14. Acceptabilité du test VIH proposé aux nourrissons dans les services pédiatriques, en Côte d'Ivoire, Significations pour la couverture du diagnostic pédiatrique

    PubMed Central

    Oga, Maxime; Brou, Hermann; Dago-Akribi, Hortense; Coffie, Patrick; Amani-Bossé, Clarisse; Ékouévi, Didier; Yapo, Vincent; Menan, Hervé; Ndondoki, Camille; Timité-Konan, M.; Leroy, Valériane

    2014-01-01

    Résumé Problème: Le dépistage VIH chez les enfants a rarement été au centre des préoccupations des chercheurs. Quand le dépistage pédiatrique a retenu l'attention, cela a été pour éclairer seulement sur les performances diagnostiques en ignorant même que le test pédiatrique comme bien d'autres peut s'accepter ou se refuser. Cet article met au cœur de son analyse les raisons qui peuvent expliquer qu'on accepte ou qu'on refuse de faire dépister son enfant. Objectif: Etudier chez les parents, les mères, les facteurs explicatifs de l'acceptabilité du test VIH des nourrissons de moins de six mois. Méthodes: Entretien semi-directif à passages répétés avec les parents de nourrissons de moins de six mois dans les formations sanitaires pour la pesée/vaccination et les consultations pédiatriques avec proposition systématique d'un test VIH pour leur nourrisson. Résultats: Nous retenons que la réalisation effective du test pédiatrique du VIH chez le nourrisson repose sur trois éléments. Primo, le personnel de santé par son discours (qui dénote de ses connaissances et perceptions même sur l'infection) orienté vers les mères influence leur acceptation ou non du test. Secundo, la mère qui par ses connaissances et perceptions même sur le VIH, dont le statut particulier, l'impression de bien-être chez elle et son enfant influence toute réalisation du test pédiatrique VIH. Tertio, l'environnement conjugal de la mère, particulièrement caractérisé par les rapports au sein du couple, sur la facilité de parler du test VIH et sa réalisation chez les deux parents ou chez la mère seulement sont autant de facteurs qui influencent la réalisation effective du dépistage du VIH chez l'enfant. Le principe préventif du VIH, et le désir de faire tester l'enfant ne suffisent pas à eux seuls pour aboutir à sa réalisation effective, selon certaines mères confrontées au refus du conjoint. A l'opposé, les autres mères refusant la réalisation du test pédiatrique disent s'y opposer ; bien entendu, même dans le cas où le conjoint l'accepterait. Discussion: Les mères sont les principales mises en cause et craignent les réprimandes et la stigmatisation. Le père, le conjoint peut être un obstacle, quand il s'oppose au test VIH du nourrisson, ou devenir le facilitateur de sa réalisation s'il est convaincu. Le positionnement du père demeure donc essentiel dans la question de l'acceptabilité du VIH pédiatrique. Les mères en ont conscience et présagent des difficultés à faire dépister ou non les enfants sans avis préalable du conjoint à la fois père, et chef de famille. Conclusion: La question du dépistage pédiatrique du VIH, au terme de notre analyse, met en face trois éléments qui exigent une gestion globale pour assurer une couverture effective. Ces trois éléments n'existeraient pas sans s'influencer, donc ils sont constamment en interaction et empêchent ou favorisent la réalisation ou non du test pédiatrique. Aussi, dans une intention d'aboutir à une couverture effective du dépistage VIH des nourrissons, faut-il tenir compte d'une gestion harmonieuse de ces trois éléments: La première, la mère seule (avec ses connaissances, ses perceptions), son environnement conjugal (de proposition du test intégrant 1- l’époux et / ou père de l'enfant avec ses perceptions et connaissances sur l'infection 2- la facilité de parler du test et sa réalisation chez les deux ou un des parents, la mère) et les connaissances, attitudes et pratiques du personnel de l’établissement sanitaire sur l'infection du VIH. Recommandations: Nos recommandations proposent une redéfinition de l'approche du VIH/sida vers des familles exposées au VIH et une intégration plus accentuée du père facilitant leur propre acceptation du test VIH et celle de leur enfant. PMID:25088574

  15. Pathogenesis of duck circovirus genotype 1 in experimentally infected Pekin ducks.

    PubMed

    Hong, Y-T; Kang, M; Jang, H-K

    2018-05-17

    Ducks infected with duck circovirus (DuCV) exhibit feathering disorder, growth retardation, and low body weight. The virus can induce immunosuppression and increase rates of infection caused by other pathogens. The purpose of the present study was to investigate the pathogenesis of DuCV in experimentally infected Pekin ducks. At postmortem examination, gross lesions were observed in the immune organs including bursa of Fabricius (BF), thymus, and spleen. Hemorrhage, lymphocytic depletion, necrosis, and degeneration were observed in the bursal tissues by histological examination. The TUNEL assay was performed with bursal tissue. There was a significant difference of the apoptosis rate between the negative and DuCV-infected ducks. The earliest time point for detection of DuCV DNA in sera, cloacal swabs, and organs was 1 wk post-infection (WPI). Viral shedding was persistent and detectable at the end of the experiment (10 WPI). The findings provide evidence that horizontal transmission and persistent infection are the characteristics of DuCV. The organ with the highest mean viral load was the spleen, followed by BF, cecal tonsil, lung, thymus, liver, and kidney. We successfully established an experimental DuCV genotype 1 (DuCV-1) infection in Pekin ducks and demonstrated the pathogenicity and persistence of DuCV-1. In conclusion, DuCV-1 caused extensive damage to the immune organs that may have resulted in immunosuppression. Pathobiological characteristics of DuCV-1 include systemic infection, persistent infection, and horizontal transmission. These features allow DuCV-1 to circulate more easily in farms and increase the susceptibility of ducks to other diseases.

  16. Personnel

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2006-10-13

    Le président du conseil M.Doran explique la décision que le conseil du Cern vient de prendre sur la 4.étape du régime complémentaire des pensions. Le président du comité des finances le Dr.Andersen ainsi que le Prof.Connor(?) prennent aussi la parole

  17. 27 CFR 12.21 - List of examples of names by country.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...-Fronsac, Cassis, Cerons, Charlemagne, Chateau Chalon, Chateau-Grillet, Chinon, Chorey-les-Beaunes, Clos de Tart, Clos des Lambrays, Clos Saint-Denis, Collioure, Condrieu, Cornas, Coteaux de l'Aubance, Coteaux du Languedoc, Coteaux du Loir, Coteaux du Lyonnais, Coteaux du Tricastin, Cotes de Duras, Cotes de...

  18. 27 CFR 12.21 - List of examples of names by country.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...-Fronsac, Cassis, Cerons, Charlemagne, Chateau Chalon, Chateau-Grillet, Chinon, Chorey-les-Beaunes, Clos de Tart, Clos des Lambrays, Clos Saint-Denis, Collioure, Condrieu, Cornas, Coteaux de l'Aubance, Coteaux du Languedoc, Coteaux du Loir, Coteaux du Lyonnais, Coteaux du Tricastin, Cotes de Duras, Cotes de...

  19. Estimates of groundwater age from till and carbonate bedrock hydrogeologic units at Jefferson Proving Ground, Southeastern Indiana, 2007-08

    USGS Publications Warehouse

    Buszka, Paul M.; Lampe, David C.; Egler, Amanda L.

    2010-01-01

    During 2007-08, the U.S. Geological Survey, in cooperation with the U.S. Department of the Army, conducted a study to evaluate the relative age of groundwater in Pre-Wisconsinan till and underlying shallow and deep carbonate bedrock units in and near an area at Jefferson Proving Ground (JPG), southeastern Indiana, which was used during 1984-94 to test fire depleted uranium (DU) penetrators. The shallow carbonate unit includes about the upper 40 feet of bedrock below the bedrock-till surface; the deeper carbonate unit includes wells completed at greater depth. Samples collected during April 2008 from 15 wells were analyzed for field water-quality parameters, dissolved gases, tritium, and chlorofluorocarbon (CFC) compounds; samples from 14 additional wells were analyzed for tritium only. Water-level gradients in the Pre-Wisconsinan till and the shallow carbonate unit were from topographically higher areas toward Big Creek and Middle Fork Creek, and their tributaries. Vertical gradients were strongly downward from the shallow carbonate unit toward the deep carbonate unit at 3 of 4 paired wells where water levels recovered after development; indicating the general lack of flow between the two units. The lack of post development recovery of water levels at 4 other wells in the deep carbonate unit indicate that parts of that unit have no appreciable permeability. CFC and tritium-based age dates of Pre-Wisconsinan till groundwater are consistent with infiltration of younger (typically post-1960 age) recharge that 'mixes' with older recharge from less permeable or less interconnected strata. Part of the recharge to three till wells dated from the early to mid-1980s (JPG-DU-03O, JPG-DU-09O, and JPG-DU-10O). Age dates of young recharge in water from two till wells predated 1980 (JPG-DU-04O and JPG-DU-06O). Tritium-based age dates of water from seven other till wells indicated post-1972 age recharge. Most wells in the Pre-Wisconsinan till have the potential to produce groundwater that partially was recharged during or after DU penetrator testing; their water quality can indicate the presence of DU-related contaminants. The shallow carbonate unit near Big Creek is a karst flow system that may be recharged in part from areas with smaller thicknesses of overlying till or through more permeable parts of the till. This is indicated by CFC- and tritium-based piston-flow (non-mixing) model age dates of early-1980s for water from JPG-DU-02I, similar tritium-based ages of water produced from nearby wells MW-5 and MW-11, and cave development along the creek. The CFC and tritium-based age dates indicate that water samples from JPG-DU-01I and JPG-DU-03I were best described as mixtures of post-1984 modern recharge and submodern (1953 or older) recharge. These five wells produced groundwater that was recharged, at least partially, during or after DU-penetrator testing and are within or downgradient from the DU Impact Area with respect to groundwater flow directions inferred from water-level contours. Wells with groundwater age dates that are near to or after the onset (1984) of DU penetrator testing and that have a plausible connection to a contaminant source can be used to indicate the presence or absence of contaminants from DU penetrator or DU-related corrosion products in groundwater. Groundwater-age dates indicate that the ages of recharge sampled from shallow carbonate unit wells JPG-DU-04I, JPG-DU-05I, JPG-DU-06I, JPG-DU-09I, and JPG-DU-10D in easternmost (upgradient) and southernmost wells in the shallow carbonate unit are submodern (1953 or older) and predate the DU testing by at least 30 or more years. Water-quality data from these five wells are not likely to represent effects from DU-projectile testing or corrosion for years. Well JPG-DU-09D in the deep carbonate unit produced groundwater samples with a submodern (1953 or older) age date. The slow recovery of water levels in most wells in the deep carbonate unit is consis

  20. Depleted Uranium—Experience of the United Nations Environmental Programme Missions

    NASA Astrophysics Data System (ADS)

    Åkerblom, Gustav

    2008-08-01

    Depleted Uranium (DU) is used in ammunition designed for armour-piercing. DU was used in the Gulf war 1991, wars in Bosnia 1994-1995, Kosovo 1999 and Iraq 2003. The United Nations Environmental Programme (UNEP) Post-Conflict Branch investigated sites where DU was used and evaluated health and environmental risks during missions to Kosovo, Serbia and Bosnia. During a mission to Lebanon in 2006, UNEP also sampled areas where DU was supposed to have been used but did not find any DU. Due to the grave risks to the lives of UN personnel, no UNEP mission was carried out in Iraq. UNEP has provided training for personnel engaged in decontamination of DU in Bosnia and Iraq.

  1. Choice & Freedom.

    ERIC Educational Resources Information Center

    Kane, Pearl Rock

    2003-01-01

    Interview with Milton Friedman, Nobel Laureate economist, who discusses his ideas on school vouchers, recalling his famous 1955 essay in which he argued that there is no need for government to run schools. Also discusses the power of teacher unions and offers advice to preservice teachers. (WFA)

  2. Nuclear cloning and direct reprogramming: the long and the short path to Stockholm.

    PubMed

    Jaenisch, Rudolf

    2012-12-07

    The two winners of the 2012 Nobel Prize in Physiology or Medicine share more than just this honor; they are both also fearless adventurers, in science and beyond. Copyright © 2012 Elsevier Inc. All rights reserved.

  3. Cosmic Balloons

    ERIC Educational Resources Information Center

    El Abed, Mohamed

    2014-01-01

    A team of French high-school students sent a weather balloon into the upper atmosphere to recreate Viktor Hess's historical experiment that demonstrated the existence of ionizing radiation from the sky--later called cosmic radiation. This discovery earned him the Nobel Prize for Physics in 1936.

  4. Rewarding success

    NASA Astrophysics Data System (ADS)

    captainbonkers

    2015-01-01

    In reply to the news article "LED firm rejects Nobel laureate's olive branch" (December 2014 p7, http://ow.ly/EgLs7) about the long-running feud between Shuji Nakamura and his former employer, Nichia, over compensation for patents on efficient blue light-emitting diodes.

  5. Credit where credit's due?

    NASA Astrophysics Data System (ADS)

    Hargittai, Magdolna

    2012-09-01

    It is often said that physicist Chien-Shiung Wu, who was born 100 years ago, should have received a share in the 1957 Nobel Prize for Physics but missed out as a result of gender discrimination. Magdolna Hargittai investigates the truth of the matter.

  6. Genetic Engineering: and the Law

    ERIC Educational Resources Information Center

    Australian Journal of Mental Retardation, 1977

    1977-01-01

    In a transcript from a radio show, Nobel Prize Winner Sir Macfarlane Burnet stresses the critical need for scientists to regulate their own activities in genetic research and cites the potential danger of creating a new form of polio which might escape. (CL)

  7. Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel

    PubMed Central

    Kharaziha, Pedram; Chioureas, Dimitris; Rutishauser, Dorothea; Baltatzis, George; Lennartsson, Lena; Fonseca, Pedro; Azimi, Alireza; Hultenby, Kjell; Zubarev, Roman; Ullén, Anders; Yachnin, Jeffrey; Nilsson, Sten; Panaretakis, Theocharis

    2015-01-01

    Docetaxel is a cornerstone treatment for metastatic, castration resistant prostate cancer (CRPC) which remains a leading cause of cancer-related deaths, worldwide. The clinical usage of docetaxel has resulted in modest gains in survival, primarily due to the development of resistance. There are currently no clinical biomarkers available that predict whether a CRPC patient will respond or acquire resistance to this therapy. Comparative proteomics analysis of exosomes secreted from DU145 prostate cancer cells that are sensitive (DU145 Tax-Sen) or have acquired resistance (DU145 Tax-Res) to docetaxel, demonstrated significant differences in the amount of exosomes secreted and in their molecular composition. A panel of proteins was identified by proteomics to be differentially enriched in DU145 Tax-Res compared to DU145 Tax-Sen exosomes and was validated by western blotting. Importantly, we identified MDR-1, MDR-3, Endophilin-A2 and PABP4 that were enriched only in DU145 Tax-Res exosomes. We validated the presence of these proteins in the serum of a small cohort of patients. DU145 cells that have uptaken DU145 Tax-Res exosomes show properties of increased matrix degradation. In summary, exosomes derived from DU145 Tax-Res cells may be a valuable source of biomarkers for response to therapy. PMID:25844599

  8. Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.

    PubMed

    Kharaziha, Pedram; Chioureas, Dimitris; Rutishauser, Dorothea; Baltatzis, George; Lennartsson, Lena; Fonseca, Pedro; Azimi, Alireza; Hultenby, Kjell; Zubarev, Roman; Ullén, Anders; Yachnin, Jeffrey; Nilsson, Sten; Panaretakis, Theocharis

    2015-08-28

    Docetaxel is a cornerstone treatment for metastatic, castration resistant prostate cancer (CRPC) which remains a leading cause of cancer-related deaths, worldwide. The clinical usage of docetaxel has resulted in modest gains in survival, primarily due to the development of resistance. There are currently no clinical biomarkers available that predict whether a CRPC patient will respond or acquire resistance to this therapy. Comparative proteomics analysis of exosomes secreted from DU145 prostate cancer cells that are sensitive (DU145 Tax-Sen) or have acquired resistance (DU145 Tax-Res) to docetaxel, demonstrated significant differences in the amount of exosomes secreted and in their molecular composition. A panel of proteins was identified by proteomics to be differentially enriched in DU145 Tax-Res compared to DU145 Tax-Sen exosomes and was validated by western blotting. Importantly, we identified MDR-1, MDR-3, Endophilin-A2 and PABP4 that were enriched only in DU145 Tax-Res exosomes. We validated the presence of these proteins in the serum of a small cohort of patients. DU145 cells that have uptaken DU145 Tax-Res exosomes show properties of increased matrix degradation. In summary, exosomes derived from DU145 Tax-Res cells may be a valuable source of biomarkers for response to therapy.

  9. Depleted Uranium and Human Health.

    PubMed

    Faa, Armando; Gerosa, Clara; Fanni, Daniela; Floris, Giuseppe; Eyken, Peter V; Lachowicz, Joanna I; Nurchi, Valeria M

    2018-01-01

    Depleted uranium (DU) is generally considered an emerging pollutant, first extensively introduced into environment in the early nineties in Iraq, during the military operation called "Desert Storm". DU has been hypothesized to represent a hazardous element both for soldiers exposed as well as for the inhabitants of the polluted areas in the war zones. In this review, the possible consequences on human health of DU released in the environment are critically analyzed. In the first part, the chemical properties of DU and the principal civil and military uses are summarized. A concise analysis of the mechanisms underlying absorption, blood transport, tissue distribution and excretion of DU in the human body is the subject of the second part of this article. The following sections deal with pathological condition putatively associated with overexposure to DU. Developmental and birth defects, the Persian Gulf syndrome, and kidney diseases that have been associated to DU are the arguments treated in the third section. Finally, data regarding DU exposure and cancer insurgence will be critically analyzed, including leukemia/lymphoma, lung cancer, uterine cervix cancer, breast cancer, bladder cancer and testicular cancer. The aim of the authors is to give a contribution to the debate on DU and its effects on human health and disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  10. Characterization of FaDu-R, a radioresistant head and neck cancer cell line, and cancer stem cells.

    PubMed

    Cho, Kwang-Jae; Park, Eun-Ji; Kim, Min-Sik; Joo, Young-Hoon

    2018-06-01

    The aim of this study was to evaluate the impact of CSC on insensitivity to radiotherapy in HNSCC. A radioresistant cell line, FaDu-R, was established using fractionated ionizing radiation. Cells with high and low CD44/ALDH activity were isolated. FaDu-R cells demonstrated significantly increased cell viability after radiation exposure compared with parental cells. CD44 high /ALDH high FaDu-R cells demonstrated significantly faster wound closure (p<0.05) and more efficient invasion (p<0.05) compared to the CD44 high /ALDH high FaDu cells or the CD44 low /ALDH low FaDu-R cells. There was a significant difference in tumor volume between the CD44 high /ALDH high FaDu-R cells and the CD44 high /ALDH high FaDu cells (p<0.05) as well as the CD44 low /ALDH low FaDu-R cells (p<0.05). Cancer stem cells (CSC) were associated with invasion and tumorigenesis in a radioresistant head and neck squamous cell carcinoma (HNSCC) cell line. This concept might help to improve the understanding of these mechanisms and to develop drugs that can overcome radioresistance during radiotherapy. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Gulf war depleted uranium risks.

    PubMed

    Marshall, Albert C

    2008-01-01

    US and British forces used depleted uranium (DU) in armor-piercing rounds to disable enemy tanks during the Gulf and Balkan Wars. Uranium particulate is generated by DU shell impact and particulate entrained in air may be inhaled or ingested by troops and nearby civilian populations. As uranium is slightly radioactive and chemically toxic, a number of critics have asserted that DU exposure has resulted in a variety of adverse health effects for exposed veterans and nearby civilian populations. The study described in this paper used mathematical modeling to estimate health risks from exposure to DU during the 1991 Gulf War for both US troops and nearby Iraqi civilians. The analysis found that the risks of DU-induced leukemia or birth defects are far too small to result in an observable increase in these health effects among exposed veterans or Iraqi civilians. The analysis indicated that only a few ( approximately 5) US veterans in vehicles accidentally targeted by US tanks received significant exposure levels, resulting in about a 1.4% lifetime risk of DU radiation-induced fatal cancer (compared with about a 24% risk of a fatal cancer from all other causes). These veterans may have also experienced temporary kidney damage. Iraqi children playing for 500 h in DU-destroyed vehicles are predicted to incur a cancer risk of about 0.4%. In vitro and animal tests suggest the possibility of chemically induced health effects from DU internalization, such as immune system impairment. Further study is needed to determine the applicability of these findings for Gulf War exposure to DU. Veterans and civilians who did not occupy DU-contaminated vehicles are unlikely to have internalized quantities of DU significantly in excess of normal internalization of natural uranium from the environment.

  12. Identification of alternatively spliced isoforms of interleukin-2/15 receptor β chain in ducks.

    PubMed

    Jeong, Jipseol; Kim, Woo H; Yeo, Jaeseung; Fernandez, Cherry P; Kim, Suk; Lee, Youn-Jeong; Lillehoj, Hyun S; Min, Wongi

    2014-12-15

    Interleukin (IL)-2 and IL-15 receptor β (IL-2/15Rβ, CD122) play important roles in signal transduction for biological functions of IL-2 and IL-15. We found that ducks possess three different IL-2/15Rβ transcripts, a conventional form (duIL-2/15Rβ) and two variants. Comparisons between the cDNA and genomic sequences revealed that the two variants, duIL-2/15Rβ-d7 and duIL-2/15Rβ-d9, were novel spliced transcripts resulting from skipping exons 7 and 9, respectively. Expression profiles of duIL-2/15Rβ and its isoforms were examined in healthy tissues, concanavalin A (ConA)-stimulated splenic lymphocytes and in livers and spleens of Riemerella anatipestifer-infected ducks using quantitative real-time PCR (qRT-PCR). Generally, duIL-2/15Rβ-d9 expression was undetectable in healthy tissues, ConA-activated samples, and R. anatipestifer-infected ducks. Expression levels of duIL-2/15Rβ transcript were relatively high to moderate in all healthy tissues tested, while duIL-2/15Rβ-d7 expression was low. Compared to untreated controls, expression levels of duIL-2/15Rβ were elevated in ConA-activated splenic lymphocytes and in livers on day 7 in R. anatipestifer-infected ducks, while duIL-2/15Rβ-d7 expression was unchanged. Additionally, COS-7 cells transfected with duIL-2/15Rβ, duIL-2/15Rβ-d7, or duIL-2/15Rβ-d9 constructs generated 73 kilodalton (kDa), 31kDa, and 40kDa proteins, respectively. This study identified three different IL-2/15Rβ transcripts, including two isoforms generated by alternative splicing and their gene expression patterns in stimulated conditions. Copyright © 2014 Elsevier B.V. All rights reserved.

  13. Lignes directrices sur l’aiguillage des cas soupçonnés de cancer du poumon par un médecin de famille ou autre professionnel des soins primaires

    PubMed Central

    Del Giudice, M. Elisabeth; Young, Sheila-Mae; Vella, Emily T.; Ash, Marla; Bansal, Praveen; Robinson, Andrew; Skrastins, Roland; Ung, Yee; Zeldin, Robert; Levitt, Cheryl

    2014-01-01

    Résumé Objectif Les présentes lignes directrices visent à aider les médecins de famille et autres généralistes à reconnaître les manifestations cliniques devant éveiller les soupçons quant à la présence d’un cancer du poumon chez les patients. Composition du comité Les membres du comité ont été choisis parmi les leaders régionaux en soins primaires du Réseau provincial des soins primaires et de la lutte contre le cancer d’Action Cancer Ontario et parmi les membres du Groupe sur le siège de la maladie, Cancer du poumon d’Action Cancer Ontario. Méthodes Les présentes lignes directrices sont le fruit d’une revue systématique des données probantes, d’une synthèse des données et d’un examen externe formel effectué par des intervenants canadiens qui ont validé la pertinence des recommandations. Rapport Ces lignes directrices fondées sur des données probantes ont été formulées pour améliorer la prise en charge en contexte canadien des patients qui présentent des manifestations cliniques du cancer du poumon. Conclusion Le dépistage et l’aiguillage précoces des patients atteints de cancer du poumon pourraient en fin de compte aider à réduire les morbidités et mortalités liées au cancer. Ces lignes directrices pourraient aussi s’avérer utiles dans la mise sur pied de programmes de diagnostic du cancer du poumon et pour aider les décideurs à veiller à ce que les ressources appropriées soient en place.

  14. High frequency EMI sensing for estimating depleted uranium radiation levels in soil

    NASA Astrophysics Data System (ADS)

    Shubitidze, Fridon; Barrowes, Benjamin E.; Ballard, John; Unz, Ron; Randle, Adam; Larson, Steve L.; O'Neill, Kevin A.

    2018-04-01

    This paper studies high (100 kHz up to 15 MHz) frequency electromagnetic responses (HFEMI) for DU metallic pieces and DU contaminated soils and derives a simple empirical expression from the measured HFEMI data for estimating DU contamination levels in soil. Depleted uranium (DU) is the byproduct of uranium enrichment and contains 33% less radioactive isotopes than natural uranium. There are at least thirty facilities at fourteen separate locations in the US, where munitions containing DU have been evaluated or used for training. At these sites, which vary in size, evaluation studies have been conducted with and without catch boxes. In addition, the DoD used DU at open firing ranges as large as thousands of acres (hundreds of hectares), for both artillery and aircraft training. These activities have left a legacy of DU contamination. Currently at military sites where DU munitions have been or are being used, cleanup activities mainly are done by excavating and shipping large volumes of site soil and berm materials to a hazardous material radiation disposal site. This approach is very time consuming, costly, and associated with the potential for exposure of personnel performing excavation and transportation. It also limits range use during the operation. So, there is an urgent need for technologies for rapid surveying of large areas to detect, locate, and removal of DU contaminants at test sites. Additionally, the technologies are needed to detect material at a depth of at least 30 cm as well as discriminate between DU metals and oxides from natural uranium and from other conductive metals such as natural and man-made range clutter. One of the potential technologies for estimating DU radiation levels in soils is HFEMI sensing. In this paper, HFEMI signals are collected for DU metal pieces, sodium diunarate (Na2U2 O3) and tri-uranium octoxide (U3O8). The EMI signal's sensitivity with respect to DU material composition and conditions are illustrated and analyzed. A new scheme for extracting near-surface soil's EM parameters is formulated.

  15. Prévalence du portage asymptomatique du plasmodium chez les donneurs bénévoles de sang à Kisangani, République Démocratique du Congo

    PubMed Central

    Bassandja, Jacques Ossinga; Agasa, Salomon Batina; Likwela, Joris Losimba

    2014-01-01

    Introduction Le paludisme transfusionnel est une réalité en Afrique Sub-saharienne, en raison des transfusions sanguines répétées, peu ou non contrôlées et où les donneurs sont en majorité potentiellement porteurs d'hématozoaires. L'objectif de cette étude était de déterminer la prévalence du portage asymptomatique du plasmodium chez les donneurs bénévoles de sang à Kisangani. Méthodes Une étude transversale a été menée au Centre Provincial de Transfusion Sanguine à Kisangani du 1er Décembre 2012 au 31 Mars 2013 et a concerné 480 donneurs bénévoles de sang. Résultats La prévalence du portage asymptomatique du plasmodium chez les donneurs bénévoles de sang était de 28,3%. Plasmodium falciparum était l'espèce la plus répandue (96,3%). Près de la moitié des donneurs avait une parasitémie supérieure à 2000 parasites/µl. Les facteurs qui étaient significativement associés à la parasitémie étaient le jeune âge, le 1er don, et la non utilisation de la moustiquaire imprégnée d'insecticide à longue durée (MILD). Conclusion Les résultats de cette étude montrent que la prévalence du portage asymptomatique du plasmodium chez les donneurs bénévoles de sang était élevée, constituant ainsi un risque important de transmission du parasite aux receveurs souvent en mauvais état général. Cependant, l'utilisation de la MILD et la fidélisation des donneurs bénévoles semblent constituer des moyens utiles de réduction du risque de portage asymptomatique du Plasmodium. Une sensibilisation et éventuellement des distributions ciblées de MILD aux donneurs, en particuliers les plus jeunes, pourraient réduire considérablement le portage du Plasmodium parmi les donneurs de sang et ainsi réduire le risque de paludisme transfusionnel. PMID:25328616

  16. Le role du phytoplancton de petite taille (<20 mum) dans les variations des proprietes optiques des eaux du Saint-Laurent

    NASA Astrophysics Data System (ADS)

    Mas, Sebastien

    Les mesures satellitaires de couleur des oceans sont largement determinees par les proprietes optiques inherentes (IOPs) des eaux de surface. D'autre part, le phytoplancton de petite taille (<20 mum) est le plus souvent dominant dans les oceans, et peut donc etre une source importante de variation des IOPs dans les oceans. Dans ce contexte, le but principal de ce doctorat etait de definir l'impact du phytoplancton (<20 mum) sur les variations des proprietes optiques de l'Estuaire et du Golfe du Saint-Laurent (Canada). Afin d'atteindre cet objectif, il etait necessaire de determiner en milieu controle les facteurs de variabilite des proprietes optiques cellulaires et des IOPs du phytoplancton (<20 mum) des eaux du Saint-Laurent, et d'evaluer la contribution du phytoplancton (<20 mum) aux proprietes optiques totales des eaux du Saint-Laurent. Des experiences en laboratoire ont montre que les variations des proprietes optiques des cellules phytoplanctoniques soumises a un cycle jour-nuit, ainsi qu'a des changements concomitants d'intensite lumineuse, peuvent contribuer significativement a la variabilite des proprietes optiques observee en milieu naturel. D'autres experiences ont, quant a elles, mis en evidence que les variations des proprietes optiques des cellules phytoplanctoniques dues aux phases de croissance peuvent alterer les IOPs des oceans, particulierement pendant les periodes de floraison. De plus, la presence de bacteries et de particules detritiques peut egalement affecter la variabilite des IOPs totales, notamment la diffusion. Au printemps, dans l'Estuaire et le Golfe du Saint-Laurent, la contribution du phytoplancton <20 mum aux IOPs presentait des differences regionales evidentes pour les proprietes d'absorption et de diffusion. En plus de la variabilite spatiale, les proprietes optiques cellulaires presentaient des variations journalieres, et ce particulierement pour le picophytoplancton. Enfin, la plupart des differences observees dans les proprietes biooptiques, particulierement l'absorption, etaient attribuables a la contribution du phytoplancton <20 mum. Ceci confirme l'importance de la structure de taille des communautes phytoplanctoniques dans les modeles bio-optiques appliques au Saint-Laurent. L'ensemble des resultats a permis de mettre en evidence l'importance des mecanismes de photoacclimatation et de synchronisation du cycle cellulaire du phytoplancton sur les variations journalieres des IOPs, ainsi que de l'etat physiologique relie au stade de croissance sur les variations temporelles a long terme des IOPs. De plus, le phytoplancton <20 mum contribue de maniere importante aux IOPs et a leur variabilite dans l'Estuaire et le Golfe du St-Laurent, et ce particulierement pour l'absorption. Cette etude de doctorat souligne donc l'importance du phytoplancton <20 mum sur la variabilite des IOPs des oceans.

  17. Genomic characterization of putative allergen genes in peach/almond and their synteny with apple

    PubMed Central

    Chen, Lin; Zhang, Shuiming; Illa, Eudald; Song, Lijuan; Wu, Shandong; Howad, Werner; Arús, Pere; Weg, Eric van de; Chen, Kunsong; Gao, Zhongshan

    2008-01-01

    Background Fruits from several species of the Rosaceae family are reported to cause allergic reactions in certain populations. The allergens identified belong to mainly four protein families: pathogenesis related 10 proteins, thaumatin-like proteins, lipid transfer proteins and profilins. These families of putative allergen genes in apple (Mal d 1 to 4) have been mapped on linkage maps and subsequent genetic study on allelic diversity and hypoallergenic traits has been carried out recently. In peach (Prunus persica), these allergen gene families are denoted as Pru p 1 to 4 and for almond (Prunus dulcis)Pru du 1 to 4. Genetic analysis using current molecular tools may be helpful to establish the cause of allergenicity differences observed among different peach cultivars. This study was to characterize putative peach allergen genes for their genomic sequences and linkage map positions, and to compare them with previously characterized homologous genes in apple (Malus domestica). Results Eight Pru p/du 1 genes were identified, four of which were new. All the Pru p/du 1 genes were mapped in a single bin on the top of linkage group 1 (G1). Five Pru p/du 2 genes were mapped on four different linkage groups, two very similar Pru p/du 2.01 genes (A and B) were on G3, Pru p/du 2.02 on G7,Pru p/du 2.03 on G8 and Pru p/du 2.04 on G1. There were differences in the intron and exon structure in these Pru p/du 2 genes and in their amino acid composition. Three Pru p/du 3 genes (3.01–3.03) containing an intron and a mini exon of 10 nt were mapped in a cluster on G6. Two Pru p/du 4 genes (Pru p/du 4.01 and 4.02) were located on G1 and G7, respectively. The Pru p/du 1 cluster on G1 aligned to the Mal d 1 clusters on LG16; Pru p/du 2.01A and B on G3 to Mal d 2.01A and B on LG9; the Pru p/du 3 cluster on G6 to Mal d 3.01 on LG12; Pru p/du 4.01 on G1 to Mal d 4.03 on LG2; and Pru p/du 4.02 on G7 to Mal d 4.02 on LG2. Conclusion A total of 18 putative peach/almond allergen genes have been mapped on five linkage groups. Their positions confirm the high macro-synteny between peach/almond and apple. The insight gained will help to identify key genes causing differences in allergenicity among different cultivars of peach and other Prunus species. PMID:19014629

  18. INTRODUCTION: Physics of Low-dimensional Systems: Nobel Symposium 73

    NASA Astrophysics Data System (ADS)

    Lundqvist, Stig

    1989-01-01

    The physics of low-dimensional systems has developed in a remarkable way over the last decade and has accelerated over the last few years, in particular because of the discovery of the new high temperature superconductors. The new developments started more than fifteen years ago with the discovery of the unexpected quasi-one-dimensional character of the TTF-TCNQ. Since then the field of conducting quasi-one-dimensional organic systems have been rapidly growing. Parallel to the experimental work there has been an important theoretical development of great conceptual importance, such as charge density waves, soliton-like excitations, fractional charges, new symmetry properties etc. A new field of fundamental importance was the discovery of the Quantum Hall Effect in 1980. This field is still expanding with new experimental and theoretical discoveries. In 1986, then, came the totally unexpected discovery of high temperature superconductivity which started an explosive development. The three areas just mentioned formed the main themes of the Symposium. They do not in any way exhaust the progress in low-dimensional physics. We should mention the recent important development with both two-dimensional and one-dimensional and even zero-dimensional structures (quantum dots). The physics of mesoscopic systems is another important area where the low dimensionality is a key feature. Because of the small format of this Symposium we could unfortunately not cover these areas. A Nobel Symposium provides an excellent opportunity to bring together a group of prominent scientists for a stimulating exchange of new ideas and results. The Nobel Symposia are very small meetings by invitation only and the number of key international participants is typically in the range 25-40. These Symposia are arranged through a special Nobel Symposium Committee after proposal from individuals. This Symposium was sponsored by the Nobel Foundation through its Nobel Symposium Fund with grants from The Tercentenary Fund of the Bank of Sweden and The Knut and Alice Wallenberg Foundation. Additional support was obtained from the Royal Academy of Sciences, the Nordic Institute for Theoretical Atomic Physics (NORDITA), Chalmers University of Technology and Gothenburg University. To arrange a Nobel Symposium on such hot topics is an open invitation for criticism and trouble. The organizers tried their best to select a few topics of current interest in order to generate a strong interaction between participants and to stimulate a good discussion. I would like to express our apologies to all these prominent scientists who could not be invited because of the small format of the Symposium and the planning of the organizers. These Proceedings contain most of the material presented at the Symposium. A few participants found it inconvenient to prepare a full length paper, which would just have been a modified version of material to appear in regular journals. Others might have felt that a conference proceeding be too slow a medium in comparison with e.g. the New York Times. On the whole however these proceedings give a good report of the science discussed during the Symposium. We would like to place on record our sincere thanks to the participants who contributed substantially in the planning by making valuable suggestions about participants and topics. In particular, Bob Schrieffer did a great job in organizing the programme and effectively to run the Symposium. My co-organizers played a crucial role in the planning and during the Symposium week. Our secretary, Yvonne Steen, deserves our very special thanks for her outstanding work. I would finally like to say something about Gräftåvallen and our hosts, Annica and Tommy Hagström. We decided to take the Symposium out of academia and chose this charming tiny mountain resort on a mountain slope in the northern Swedish mountains about 20 miles from the nearest village. Annica and Tommy Hagström welcomed us with such warm hospitality and offered us throughout the week the very best of the local mountain delicacies. Also the local community greeted us as some very special guests and arranged an evening programme at a nearby shieling with goats, sheep, dairy maids, folk music and folk dancing. They also arranged a wonderful concert in their beautiful church from the 12th century. We, the organizers, experienced this symposium as a scientific event with an excellent discussion of the progress in these fields thanks to the outstanding contributions of the participants. We hope that these Proceedings will convey to the reader something of the excitement felt during the symposium week.

  19. Personnel

    ScienceCinema

    None

    2017-12-09

    Le président du conseil M.Doran explique la décision que le conseil du Cern vient de prendre sur la 4.étape du régime complémentaire des pensions. Le président du comité des finances le Dr.Andersen ainsi que le Prof.Connor(?) prennent aussi la parole

  20. W.E.B. DuBois and the Concepts of Race and Class.

    ERIC Educational Resources Information Center

    Green, Dan S.; Smith, Earl

    1983-01-01

    Summarizes and analyzes W.E.B. DuBois's publications on race and class, particularly as he observed the relationships between White and Black Americans from about 1890 to the 1960s. Contends that DuBois's work has been seriously underrated and cites William J. Wilson's work as corroborating and extending DuBois's theories. (CJM)

  1. Toward the Development of a Canadian Less Lethal Weapon Approval Process: A Study of Contemporary Process Models

    DTIC Science & Technology

    2011-10-01

    la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011...validés par l’autorité d’approbation. Lorsqu’il n’existe pas de normes officielles, on utilise une approche de gestion du risque qui comprend une plus...gouvernance qui reprend les éléments clés du modèles du Royaume-Uni, l’incorporation d’un processus de gestion du risque, un énoncé des

  2. Colloquium P.G.de Gennes

    ScienceCinema

    None

    2018-05-18

    Lecture from Professor Pierre Gilles from Gennes, who received the Nobel Prize for Physics in 1991, became a professor at the Collège de France in 1971, director of the Ecole de Physique et Chimie (School of Physics and Chemistry) in Paris, etc.

  3. George Smoot, Blackbody, and Anisotropy of the Cosmic Microwave Background

    Science.gov Websites

    , ... has been awarded the 2006 Nobel Prize for physics. He shares the award with John C. Mather of NASA we continue to support him today. In addition, one of the principal instruments for the NASA COBE

  4. 'Shockley park' stirs racism row

    NASA Astrophysics Data System (ADS)

    Gwynne, Peter

    2009-07-01

    A local authority in Northern California has encountered unexpected resistance to its decision to name a park after the Nobel-prize-winning physicist William Shockley, with a coalition of churches and civic groups preparing to petition against the name at a meeting scheduled for 23 July.

  5. Recipients of major scientific awards: A descriptive and predictive analysis

    NASA Astrophysics Data System (ADS)

    Barbee, Andrew Calvin

    Recent trends demonstrate an increase of women in leadership roles, STEM fields, and participating in higher education including graduate and doctoral programs, which is a result of Title IX. This quantitative study considered major scientific awards awarded to females and examines demographic characteristics of awardees from the Nobel, National Academy of Sciences (NAS), and National Science Foundation (NSF). More specifically, the following awards were examined the Nobel Prize in Chemistry, the NAS Public Welfare Medal, and the NSF National Medal of Science within the discipline of Physical Science. Also, this study focused on equality to determine if a fair playing field and equal opportunity for women in academics has improved since Title IX. A limited amount of research has explored female award recipients. Specifically, existing research, has not examined the pinnacle of academic performance in the form of national and international awards. In the present study, I posed research questions relating to demographic characteristics of award recipients from the Nobel, NAS, and NSF between 1975 and 2015. Additionally, I examined if sex and age of the awardees could predict early career award obtainment. Through the frame of Social cognitive theory (Bandura, 1986, 1997, and 2005) I considered how perceptions of gender roles are a product of influence by society and the possible connection to performance. Results indicated a limited number of females have received these scientific awards and the awardees age could predict receiving an award early in their career. Additionally, the study provided insight into the progression of Title IX within the context of athletics and academics. It addressed the incremental and systematic increase in academics for women at high school, college, career, and scientific awards. Perhaps most importantly, it identified an observed pattern for female science award recipients reaching a critical mass and a tipping point.

  6. Histomorphometric and whole-genome expression analysis of peri-implant soft tissue healing: a comparison of flapless and open surgery.

    PubMed

    Mueller, Cornelia Katharina; Thorwarth, Michael; Schultze-Mosgau, Stefan

    2011-01-01

    The structure of peri-implant soft tissue that is regenerated after flapless and flap surgery has been shown to differ. However, its underlying mechanisms are relatively unknown. The present study sought to identify differences in the inflammatory cell infiltration and expression of gene transcripts during transmucosal healing between the two approaches with two different implant designs. All mandibular premolars were removed from 12 minipigs. One month later, four implants (two NobelReplace Tapered Groovy and two NobelPerfect Groovy, Nobel Biocare) were placed in each quadrant. One quadrant was randomized to flapless insertion, while the other was chosen for flap surgery in each animal. Following 1, 2, 4, and 12 weeks of transmucosal implant healing, biopsy specimens were retrieved from the peri-implant soft tissue according to a standardized procedure to avoid crossover effects. Samples were subjected to a leukocyte count and a gene expression analysis. When the flapless placement technique was used, leukocyte influx in the peri-implant soft tissue was significantly smaller compared to open surgery for both implant designs. Gene expression analysis revealed significant overexpression of molecules associated with detoxification and reepithelialization in the flapless group. In contrast, myofibroblast-associated gene transcripts were significantly enriched in the flap surgery group. The present data indicate perpetuation of inflammatory reactions as well as increased fibrotic scar tissue deposition in the peri-implant area following implant placement by the flap approach. Flapless implant insertion results in less inflammation and early reepithelialization, providing the potential for the formation of a fully functioning as well as esthetically preferable peri-implant soft tissue collar.

  7. Digital ulcers in systemic sclerosis: role of flow-mediated dilatation and capillaroscopy as risk assessment tools.

    PubMed

    Silva, Ivone; Loureiro, Tiago; Teixeira, Andreia; Almeida, Isabel; Mansilha, Armando; Vasconcelos, Carlos; Almeida, Rui

    2015-01-01

    The aim of this study was to evaluate macrovascular endothelial dysfunction and microvascular damage as clinical markers of peripheral microangiopathy in patients with Raynaud's phenomenon (RP). Seventy-seven secondary RP with systemic sclerosis, 32 primary RP and 34 healthy controls were included in our study. Secondary RP patients were divided into two subgroups: 39 with digital ulcers (DU) and 38 without digital ulcers (non-DU). Patients with DU had significantly lower flow-mediated dilatation values (5.34 ± 7.49%) compared to non-DU patients (16.21 ± 11.31%), primary RP (17.96 ± 12.78%) and controls (20.17 ± 8.86%), p<0.001, favouring macrovascular endothelium dysfunction. Regarding microvascular damage, the DU group had a predominately capillaroscopic late pattern (71.1%) whereas non-DU patients had an active pattern (56.4%). The microangiopathy evolution score was significantly higher in the DU group compared to the non-DU group (4.79 ± 1.82 vs. 1.79 ± 1.56, p<0.001). Flow-mediated dilation was significantly lower in late pattern (6.13 ± 7.09%) compared to active (12.58 ± 10.66%) and early patterns (17.72 ± 14.90%), p = 0.016 and p = 0.044 respectively. Low flow-mediated dilatation and microvascular damage in capillaroscopy are early clinical markers of DU risk in RP patients.

  8. Applications of Capstone depleted uranium aerosol risk data to military combat risk management.

    PubMed

    Daxon, Eric G; Parkhurst, Mary Ann; Melanson, Mark A; Roszell, Laurie E

    2009-03-01

    Risks to personnel engaged in military operations include not only the threat of enemy firepower but also risks from exposure to other hazards such as radiation. Combatant commanders of the U.S. Army carefully weigh risks of casualties before implementing battlefield actions using an established paradigm that takes these risks into consideration. As a result of the inclusion of depleted uranium (DU) anti-armor ammunition in the conventional (non-nuclear) weapons arsenal, the potential for exposure to DU aerosols and its associated chemical and radiological effects becomes an element of the commanders' risk assessment. The Capstone DU Aerosol Study measured the range of likely DU oxide aerosol concentrations created inside a combat vehicle perforated with a DU munition, and the Capstone Human Health Risk Assessment (HHRA) estimated the associated doses and calculated risks. This paper focuses on the development of a scientific approach to adapt the risks from DU's non-uniform dose distribution within the body using the current U.S. Department of Defense radiation risk management approach. The approach developed equates the Radiation Exposure Status categories to the estimated radiological risks of DU and makes use of the Capstone-developed Renal Effects Group as a measure of chemical risk from DU intake. Recommendations are provided for modifying Army guidance and policy in order to better encompass the potential risks from DU aerosol inhalation during military operations.

  9. Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage

    PubMed Central

    Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; Abbassi, A.; Belmahi, A.M.

    2011-01-01

    Summary Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondaires à des brûlures électriques par haut voltage de diamètre allant de 8 à 11 cm et siégeant dans la région tonsurale. Ces patients ont été opérés dans la première semaine suivant l’accident. Les pertes de substance du scalp de taille moyenne secondaires à ces brûlures peuvent être couvertes per primam de façon fiable par des lambeaux locaux axialisés et multiples. Nous relatons l’expérience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc, dans la gestion et la prise en charge de ces brûlures. PMID:22262963

  10. The brain is a target organ after acute exposure to depleted uranium.

    PubMed

    Lestaevel, P; Houpert, P; Bussy, C; Dhieux, B; Gourmelon, P; Paquet, F

    2005-09-01

    The health effects of depleted uranium (DU) are mainly caused by its chemical toxicity. Although the kidneys are the main target organs for uranium toxicity, uranium can also reach the brain. In this paper, the central effects of acute exposure to DU were studied in relation to health parameters and the sleep-wake cycle of adult rats. Animals were injected intraperitoneally with 144+/-10 microg DU kg-1 as nitrate. Three days after injection, the amounts of uranium in the kidneys represented 2.6 microg of DU g-1 of tissue, considered as a sub-nephrotoxic dosage. The central effect of uranium could be seen through a decrease in food intake as early as the first day after exposure and shorter paradoxical sleep 3 days after acute DU exposure (-18% of controls). With a lower dosage of DU (70+/-8 microg DU kg-1), no significant effect was observed on the sleep-wake cycle. The present study intends to illustrate the fact that the brain is a target organ, as are the kidneys, after acute exposure to a moderate dosage of DU. The mechanisms by which uranium causes these early neurophysiological perturbations shall be discussed.

  11. A review of the environmental corrosion, fate and bioavailability of munitions grade depleted uranium.

    PubMed

    Handley-Sidhu, Stephanie; Keith-Roach, Miranda J; Lloyd, Jonathan R; Vaughan, David J

    2010-11-01

    Depleted uranium (DU) is a by-product of nuclear fuel enrichment and is used in antitank penetrators due to its high density, self-sharpening, and pyrophoric properties. Military activities have left a legacy of DU waste in terrestrial and marine environments, and there have been only limited attempts to clean up affected environments. Ten years ago, very little information was available on the dispersion of DU as penetrators hit their targets or the fate of DU penetrators left behind in environmental systems. However, the marked increase in research since then has improved our knowledge of the environmental impact of firing DU and the factors that control the corrosion of DU and its subsequent migration through the environment. In this paper, the literature is reviewed and consolidated to provide a detailed overview of the current understanding of the environmental behaviour of DU and to highlight areas that need further consideration. Copyright © 2010 Elsevier B.V. All rights reserved.

  12. How diet and lifestyle affect duodenal ulcers. Review of the evidence.

    PubMed Central

    Ryan-Harshman, Milly; Aldoori, Walid

    2004-01-01

    OBJECTIVE: To demonstrate the role of diet in reducing or aggravating risk of duodenal ulcer (DU). QUALITY OF EVIDENCE: MEDLINE was searched from January 1966 to December 2001 for articles on the relationship between diet and lifestyle and DU using the key words duodenal ulcer and diet, fibre, or lifestyle. Evidence that these factors are associated with DU arose mainly from three case-control and three prospective studies (level II evidence) and from expert opinion (level III evidence). MAIN MESSAGE: A high-fibre diet appears to reduce risk of DU; soluble fibre might be associated with reduced risk also. Vitamin A intake is associated with lower risk of DU. Little evidence indicates that fat, type of fat, protein intake, or consumption of alcohol or caffeine affect the etiology of DU. CONCLUSION: A high-fibre diet, particularly if the fibre comes from fruit and vegetables, could reduce risk of DU; vitamin A might also be beneficial. PMID:15171675

  13. Hématome spontané du méso de l'angle colique droit et du colon transverse compliquant un traitement par anti vitamine K: à propos d'un cas et revue de la littérature

    PubMed Central

    Traoré, Ibrahim Alain; Zaré, Cyprien; Barro, Sié Drissa; Guibla, Ismaël

    2016-01-01

    L'hématome spontané du méso de l'angle colique droit et du transverse est une complication rare du traitement anticoagulant par antivitamine K. Nous rapportons un cas d'hématome spontané du méso de l'angle colique droit et du transverse associé à un hémopéritoine de grande abondance chez un patient traité par antivitamine K pour embolie pulmonaire consécutive à une fracture des plateaux tibiaux droits. Le diagnostic doit être fait en urgence. L’échographie abdominale et la tomodensitométrie confirment le diagnostic. Le traitement non opératoire est la règle. Le traitement chirurgical est indiqué en cas de complications telles que la rupture de l'hématome. PMID:27217878

  14. Command and Control (C2) Agility (Agilite du commandement et du controle (C2))

    DTIC Science & Technology

    2014-10-01

    de la rigueur et de l’emploi des méthodes de mesure et d’amélioration de l’agilité du C2. Le spectre des missions... Control and Intelligence (C2I) Section DRDC Valcartier 2459 de la Bravoure Road Québec (Québec) G3J 1X5 CANADA Email: Micheline.Belanger@drdc...Agilité du commandement et du contrôle (C2) (STO-TR-SAS-085) Synthèse L’agilité est la capacité à effectuer avec succès, s’occuper de

  15. Dynamique d'un oscillateur photoréfractif : instabilités et analogie avec la loi de Curie-Weiss

    NASA Astrophysics Data System (ADS)

    Mathey, P.; Odoulov, S. G.; Rytz, D.

    2002-06-01

    La dynamique et l'état stationnaire du faisceau issu d'une cavité oscillante comprenant un cristal non-linéaire de titanate de baryum utilisé en tant que miroir à conjugaison de phase sont étudiés. Le paramètre du système étant le gain du milieu non-linéaire, les dépendances de l'intensité de l'oscillation et de l'inverse du temps de réponse sont similaires aux lois de Curie en physique du solide.

  16. Les traces matérielles de la Carte du Ciel. Le cas des observatoires d'Alger et de Bordeaux.

    NASA Astrophysics Data System (ADS)

    Le Guet Tully, F.; Davoigneau, J.; Lamy, J.; de La Noë, J.; Rousseau, J.-M.; Sadsaoud, H.

    2008-06-01

    Le chapitre évoque les traces matérielles de la Carte du ciel subsistant dans les observatoires d'Alger et de Bordeaux. Les auteurs examinent d'abord l'opération d'inventaire du patrimoine astronomique entreprise à partir du milieu des années 1990. Ils examinent ensuite les éléments concrets constituant aujourd'hui le patrimoine de la Carte du Ciel : lunettes, abris, accessoires, laboratoires, réseaux, plaques de verre, registres, machines à mesurer les clichés, et cartes.

  17. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Guilmette, Ray A.; Hahn, Fletcher F.; Durbin, P. W.

    A number of U. S. veterans of the Persian Gulf War were wounded with depleted uranium (DU) metal fragments as a result of 'friendly fire' incidents, in which Abrams tanks and Bradley fighting vehicles were struck by DU anti-armor munitions. Some of the crew members who survived were left with multiple small fragments of DU in their muscles and soft tissues. The number, size and location of the fragments made them inoperable in general, and therefore subject to long-term retention. Because there was inadequate data to predict the potential carcinogenicity of DU fragments in soft tissues, Hahn et al. (2003)more » conducted a lifespan cancer study in rats. As part of that study, a number of rats were maintained to study the biokinetics and dosimetry of DU implanted intramuscularly in male Wistar rats. Typically, four metal fragments, either as cylindrical pellets or square wafers were implanted into the biceps femoris muscles of the rats. Urine samples were collected periodically during their lifespans, and DU was analyzed in kidneys and eviscerated carcass (minus the implant sites) at death. The daily DU urinary excretion rate increased steeply during the first 30 d after implantation peaking at about 90 d at 3-10 x 10{sup -3}%/d. During the first 150 d, the average excretion rate was 2.4 x 10{sup -3}%/d, decreasing thereafter to about 1 x 10{sup -3}%/d. Serial radiographs were made of the wound sites to monitor gross morphologic changes in the DU implant and the surrounding tissue. As early as 1 w after implantation, radiographs showed the presence of surface corrosion and small, dense bodies near the original implant, presumably DU. This corrosion from the surface of the implant continued with time, but did not result in an increasing amount of DU reaching the blood and urine after the first 3 mo. During this 3-mo period, connective tissue capsules formed around the implants, and are hypothesized to have reduced the access of DU to tissue fluids by limiting the diffusion rate of dissolved chemical forms of DU. Using a model of wound-site retention being developed by a committee of the U.S. National Council of Radiation Protection and Measurements (NCRP), it was found that the average retention of DU in the wound site could be described by a two-component exponential function in which 0.5% of the DU was retained with a half time of 80 d and the remainder with a half time of about 300 y.« less

  18. Nicolaas Bloembergen as a scientist and a mentor

    NASA Astrophysics Data System (ADS)

    Liu, Jia-Ming

    2018-03-01

    Nicolaas Bloembergen made rich contributions to nuclear magnetic resonance, masers and lasers, nonlinear optics and ultrafast laser-matter interactions. The Nobel laureate sadly passed away on 5 September 2017. Here are my memories of my Harvard mentor, a remarkable person and a wonderful scientist.

  19. Toni Morrison: Writing above the Ground.

    ERIC Educational Resources Information Center

    Lacour, Claudia Brodsky

    1996-01-01

    Discusses and appraises the work of Nobel Prize winning black author Toni Morrison. Locates thematic and stylistic antecedents in the works of Fyodor Dostoevsky and Ernest Hemingway. Compares and contrasts Morrison's work with Ralph Ellison's "Invisible Man" and discusses the critical reception of black authors. (MJP)

  20. A resolution congratulating the recipients of the 2012 Nobel Prize in Chemistry.

    THOMAS, 112th Congress

    Sen. Burr, Richard [R-NC

    2012-12-12

    Senate - 12/12/2012 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

  1. Smoot Group Cosmology

    Science.gov Websites

    Image: NASA WMAP George F. Smoot and John Mather share the 2006 Nobel prize "for their the Universe About Cosmology Planck Satellite Launched Cosmology Videos Professor George Smoot's group science goals regarding cosmology. George Smoot named Director of Korean Cosmology Institute The GRB

  2. General George C. Marshall

    NASA Technical Reports Server (NTRS)

    2004-01-01

    The Marshall Space Flight Center, a NASA field installation, was established at Huntsville, Alabama, in 1960. The Center was named in honor of General George C. Marshall, the Army Chief of Staff during World War II, Secretary of State, and Nobel Prize Wirner for his world-renowned Marshall Plan.

  3. On viruses, discovery, and recognition.

    PubMed

    Weiss, Robin A

    2008-12-12

    This year's Nobel Prize in Physiology or Medicine rewards the discoverers of two viruses that cause major afflictions of humankind. Identifying human papilloma virus (HPV) and human immunodeficiency virus (HIV) might now appear to have been simple, but the way forward was far from obvious at the time.

  4. The Social Responsibility of Scientists.

    ERIC Educational Resources Information Center

    Sakharov, Andrei

    1981-01-01

    Presents supportive statements from a member of the Academy of Sciences of the USSR and a Nobel Peace Prize winner that the scientific community has an obligation to inform the public fully about the impact of scientific developments. Autobiographical data concerning the author is also included. (CS)

  5. Fermilab Today

    Science.gov Websites

    (NOTE LOCATION) - One West Speaker: Regis Kopper, Duke University Title: Understanding the Benefits of DATE) - One West Speaker: Regina Demina, University of Rochester Title: Top Forward-Backward Asymmetry I play is a very interesting one," says Nobel Laureate Richard Feynman in a low-resolution

  6. What Chemists Do

    ERIC Educational Resources Information Center

    Olmsted, John, III

    2010-01-01

    An analysis is presented of the varieties of activities that have been recognized in the Nobel Prizes in chemistry. Five different varieties are identified: exploration, description, synthesis, theorizing, and measurement. Prizes in chemistry have been distributed roughly equally among these five categories. The number of awards in each category…

  7. Fermilab Today

    Science.gov Websites

    go back to my regular existence." The complete interview and Nobel Prize Veltman book Martinus Veltman's book was published in 2003. autobiography are available online. The title of Veltman's colloquium is taken from his recently published book. "Facts and Mysteries in Elementary Particle Physics

  8. Was Muller's 1946 Nobel Prize research for radiation-induced gene mutations peer-reviewed?

    PubMed

    Calabrese, Edward J

    2018-06-06

    This historical analysis indicates that it is highly unlikely that the Nobel Prize winning research of Hermann J. Muller was peer-reviewed. The published paper of Muller lacked a research methods section, cited no references, and failed to acknowledge and discuss the work of Gager and Blakeslee (PNAS 13:75-79, 1927) that claimed to have induced gene mutation via ionizing radiation six months prior to Muller's non-data Science paper (Muller, Science 66(1699):84-87, 1927a). Despite being well acclimated into the scientific world of peer-review, Muller choose to avoid the peer-review process on his most significant publication. It appears that Muller's actions were strongly influenced by his desire to claim primacy for the discovery of gene mutation. The actions of Muller have important ethical lessons and implications today, when self-interest trumps one's obligations to society and the scientific culture that supports the quest for new knowledge and discovery.

  9. Werner Forssmann, Eberswalde, the 1956 Nobel Prize for medicine.

    PubMed

    Hollmann, Wildor

    2006-10-27

    Since October 1949 Werner Forssmann was a regular guest of Prof. Dr. Hugo Wilhelm Knipping in the Medical University Clinic of Cologne. Established himself as urologist in Bad Kreuznach, Werner Forssmann had read about the American further development of heart catherization, which was invented by himself. Prof. Wilhelm Bolt, who was one of the medical station doctors of the Cologne Clinic, had already learned the technique of heart catherization in 1947. Thus, it was routinely performed in patients at the Cologne University Hospital. A close collaboration between Werner Forssmann and our research group (Hugo Wilhelm Knipping, Wilhelm Bolt, Helmut Valentin, Helmut Venrath, Hans Rink, Wildor Hollmann) was established. After the notification that Werner Forssmann had been awarded the Nobel Prize for Medicine in 1956, Hugo Wilhelm Knipping instructed me to help Werner Forssmann with the preparation of his lecture. Details of events in the year 1956 are illustrated. One of the important developments in which Werner Forssmann participated with the Medical University Clinic of Cologne was the selective pulmonary angiography.

  10. The impossible interview with the man of the hidden biological structures. Interview by Paolo Mazzarello.

    PubMed

    Golgi, Camillo

    2006-12-01

    This paper presents an "impossible interview" to Professor Camillo Golgi, placed in time in December 1906. The Italian Professor Golgi from Pavia has been awarded the Nobel Prize for Physiology or Medicine ex aequo with the Spanish anatomist Santiago Ramón y Cajal. Both scientists have obtained the award for their work on the anatomy of the nervous system. However, they have opposite views on the mechanisms underlying nervous functions. Golgi believes that the axons stained by his "black reaction" form a continuous anatomical or functional network along which nervous impulses propagate. Ramón y Cajal is the paladin of the neuron theory, a hypothesis questioned by Golgi in his Nobel lecture of Tuesday, December 11. After the ceremony, an independent journalist has interviewed Professor Golgi in the Grand Hotel in Stockholm. Excerpts about his education, his main scientific discoveries, and his personal life are here given (reconstructing the "impossible interview" on the basis of Golgi's original writings).

  11. [Ilya Ilich Metchnikov and Paul Ehrlich: 1908 Nobel Prize winners for their research on immunity].

    PubMed

    Lokaj, J; John, C

    2008-11-01

    The Nobel Prize in Physiology or Medicine in 1908 was awarded to Ilya I. Mechnikov and Paul Ehrlich for recognition of their work on immunity. Mechnikov have discovered phagocytes and phagocytosis as the basis of natural cellular immunity. His ,,phagocytic theory" is the principle of immunological concept "self and not self" as the prerequisition of physiological inflammation, and selfmaintaining of organism. Ehrlich developed the methods for standardization of antibody activity in immune sera, described neutralizing and complement-depending effect of antibodies and enunciated the ,"ide-chain" theory of the formation of antibodies. Their concept of the key-stone of immunity was different, but they expressed the basic paradigma of immunology: immunity imply the protection of identity and guarantee the integrity of organism. Both are the founders of immunology as the scientific discipline. Discoveries and conceptions of I. Mechnikov and P. Ehrlich exceedingly influenced development of immunology and are also applicable, instructive and suggestive in contemporary immunology and microbiology.

  12. Maria Goeppert Mayer and the Nobel Prize

    NASA Astrophysics Data System (ADS)

    Johnson, Karen E.

    2013-04-01

    When Maria Goeppert Mayer was awarded the Nobel Prize in Physics in 1963, she was only the second woman to receive that award and there have been no additional female physics laureates since. Mayer was uniquely prepared to carry out her prize-winning work on the nuclear shell model. Furthermore, she worked with some of the most well-known figures in mid-twentieth century physics, and her award came at a time when American science was in ascendance. Why, then, is her name so little known beyond the physics community? There are several possible answers to this question, ranging from the personal (her modest reaction to public acclaim) and the scientific (the mathematically abstract nature of her prize-winning work), to the national (the nature of the issues commanding public attention in the 1960s). In this talk I will present an overview of the circumstances that enabled Mayer to make exceptional contributions to nuclear physics, and then examine some of the possible reasons why her exceptional status is not more widely known.

  13. The meaning of the 2006 Nobel Peace Prize. Microcredit evangelism, health, and social policy.

    PubMed

    Bond, Patrick

    2007-01-01

    The awarding of the 2006 Nobel Peace Prize to Muhammad Yunus, founder of the Grameen Bank, provides an opportunity to consider the use and abuse of microfinancing, especially because credit continues to be touted as a poverty-reduction strategy associated with health education and health care financing strategies. Not only is the Grameen diagnosis of poverty dubious, but many structural problems also plague the model, ranging from financial accounting to market failures. In Southern Africa, to illustrate, microcredit schemes for peasants and small farmers have been attempted for more than 70 years, on the basis that modem capitalism and peasant/informal system gaps can be bridged by an expanded financial system. The results have been disappointing. A critical reading of political economy posits an organic linkage between the "developed" and "underdeveloped" economies that is typically not mitigated by capitalist financial markets, but instead is often exacerbated. When applied to health and social policy, microcredit evangelism becomes especially dangerous.

  14. EDITORIAL: Nobel Prize in Physiology or Medicine 2003 awarded to Paul Lauterbur and Peter Mansfield for discoveries concerning magnetic resonance imaging

    NASA Astrophysics Data System (ADS)

    Leach, Martin O.

    2004-02-01

    The award of the Nobel Prize in Physiology or Medicine recognizes discoveries concerning the use of magnetic resonance to visualize different structures. The Assembly's decision to recognize the discoveries underpinning efficient spatial mapping of biological properties reflects the singular importance of imaging to the medical application of this technique. Without this, abnormalities in morphology cannot be recognized. Equally, the wealth of physiological information that can be obtained by manipulation of the magnetic resonance signal is of little value unless localized to identified organs, pathology or areas of tissue. Based on these early discoveries, a wide range of imaging and measurement techniques, together with enabling instrumentation, have been developed over the last 30 years. Commercial equipment became available in the early 1980s, and some 60 million MRI examinations are now performed each year. The power of the technique, and the range of applications, continues to develop rapidly. The full text of this editorial is given in the PDF file below.

  15. Unusual anchor pins placement and protocol deviations during computer-based implant placement in a patient with severe mandibular bone atrophy. A case report.

    PubMed

    Pozzi, A; Tallarico, M; Barlattani, A

    2012-06-01

    The aim of the study was to describe an unusual method to stabilize the surgical template during the treatment of a severely resorbed edentulous mandible by means of computer-guided implant surgery. Pre-operative computer-based planning revealed the difficulty to stabilize the surgical template in a 67-year-old healthy woman. A deviation of the original NobelGuide™ protocol was performed to ensure the stability of the surgical template: four anchor pins were used to stabilize the surgical template, two in the buccal side of the anterior template and two unusual pins were placed in the lingual site. Four straight TiUnite® Nobel Biocare™ implants were then placed, according to a modified All-on-4™ concept procedure, to avoid graft procedures and to reduce the cumulative chair-side treatment time and costs. A temporary restoration was placed immediately after implant placement. Three months later a definitive, full acrylic restoration was delivered.

  16. Coalition Battle Management Language (C-BML) (Language de gestion du champ de bataille (C-BML)

    DTIC Science & Technology

    2012-02-01

    de gestion du champ de bataille (C-BML)) NMSG-048 Final Report. This document...BML) (Langage de gestion du champ de bataille (C-BML)) NMSG-048 Final Report. This document contains information authorized by NATO RTA for...Technical Readiness Level (TRL) that is consistent with an operational deployment. ES - 2 RTO-TR-MSG-048 Langage de gestion du champ de

  17. Characterization of Depleted-Uranium Strength and Damage Behavior

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gray, III, George T.; Chen, Shuh-Rong; Bronkhorst, Curt A.

    2012-12-17

    The intent of this report is to document the status of our knowledge of the mechanical and damage behavior of Depleted Uranium(DU hereafter). This report briefly summaries the motivation of the experimental and modeling research conducted at Los Alamos National Laboratory(LANL) on DU since the early 1980’s and thereafter the current experimental data quantifying the strength and damage behavior of DU as a function of a number of experimental variables including processing, strain rate, temperature, stress state, and shock prestraining. The effect of shock prestraining on the structure-property response of DU is described and the effect on post-shock mechanical behaviormore » of DU is discussed. The constitutive experimental data utilized to support the derivation of two constitutive strength (plasticity) models, the Preston-Tonks-Wallace (PTW) and Mechanical Threshold Stress (MTS) models, for both annealed and shock prestrained DU are detailed and the Taylor cylinder validation tests and finite-element modeling (FEM) utilized to validate these strength models is discussed. The similarities and differences in the PTW and MTS model descriptions for DU are discussed for both the annealed and shock prestrained conditions. Quasi-static tensile data as a function of triaxial constraint and spallation test data are described. An appendix additionally briefly describes low-pressure equation-of-state data for DU utilized to support the spallation experiments. The constitutive behavior of DU screw/bolt material is presented. The response of DU subjected to dynamic tensile extrusion testing as a function of temperature is also described. This integrated experimental technique is planned to provide an additional validation test in the future. The damage data as a function of triaxiality, tensile and spallation data, is thereafter utilized to support derivation of the Tensile Plasticity (TEPLA) damage model and simulations for comparison to the DU spallation data are presented. Finally, a discussion of future needs in the area of needed DU strength and damage research at LANL is presented to support the development of physically-based predictive strength and damage modeling capability.« less

  18. Evaluation of the effect of implanted depleted uranium on male reproductive success, sperm concentration, and sperm velocity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Arfsten, Darryl P.; Schaeffer, David J.; Johnson, Eric W.

    Depleted uranium (DU) projectiles have been used in battle in Iraq and the Balkans and will continue to be a significant armor-penetrating munition for the US military. As demonstrated in the Persian Gulf War, battle injury from DU projectiles and shrapnel is a possibility, and removal of embedded DU fragments from the body is not always practical because of their location in the body or their small size. Previous studies in rodents have demonstrated that implanted DU mobilizes and translocates to the gonads, and natural uranium may be toxic to spermatazoa and the male reproductive tract. In this study, themore » effects of implanted DU pellets on sperm concentration, motility, and male reproductive success were evaluated in adult (P1) Sprague-Dawley rats implanted with 0, 12, or 20, DU pellets of 1x2 mm or 12 or 20 tantalum (Ta) steel pellets of 1x2 mm. Twenty DU pellets of 1x2 mm (760 mg) implanted in a 500-g rat are equal to approximately 0.2 pound of DU in a 154-lb (70-kg) person. Urinary analysis found that male rats implanted with DU were excreting uranium at postimplantation days 27 and 117 with the amount dependent on dose. No deaths or evidence of toxicity occurred in P1 males over the 150-day postimplantation study period. When assessed at postimplantation day 150, the concentration, motion, and velocity of sperm isolated from DU-implanted animals were not significantly different from those of sham surgery controls. Velocity and motion of sperm isolated from rats treated with the positive control compound {alpha}-chlorohydrin were significantly reduced compared with sham surgery controls. There was no evidence of a detrimental effect of DU implantation on mating success at 30-45 days and 120-145 days postimplantation. The results of this study suggest that implantation of up to 20 DU pellets of 1x2 mm in rats for approximately 21% of their adult lifespan does not have an adverse impact on male reproductive success, sperm concentration, or sperm velocity.« less

  19. Cancer du sein au Maroc: profil phénotypique des tumeurs

    PubMed Central

    Khalil, Ahmadaye Ibrahim; Bendahhou, Karima; Mestaghanmi, Houriya; Saile, Rachid; Benider, Abdellatif

    2016-01-01

    Le cancer du sein est le plus fréquent chez la femme et figure parmi les principales causes de mortalité liées au cancer. La curabilité de ce type tumoral est en augmentation, grâce aux programmes de dépistage et aux progrès thérapeutiques, qui ont certes augmenté la survie des patients. Mais des défis restent à relever en rapport avec l’instabilité phénotypique des cellules cancéreuses. L’objectif de ce travail est d’étudier le profil phénotypique du cancer du sein chez les patients pris en charge au Centre Mohammed VI pour le traitement des Cancers, durant les années 2013-2014. Il s’agit d’une étude transversale sur deux années, incluant les cas du cancer du sein pris en charge au Centre. Le recueil des données était fait à partir des dossiers des patients et analysés par le logiciel Epi Info. 1277 patients ont été pris en charge au sein de notre centre. 99,5% des cas de sexe féminin, l’âge moyen était 50,20 ± 11,34 ans. Le type histologique le plus fréquent était le carcinome canalaire infiltrant (80,7% des cas). Le stade diagnostic était précoce (56,9%). Le phénotype moléculaire le plus fréquent était le luminal A (41,4% des cas). Le luminal B, le HER2 et les triples négatifs étaient dans respectivement 10,4%, 6,3%, 11,2% des cas. L’étude du phénotype tumoral des patients atteints du cancer du sein permet l’orientation du clinicien dans le choix du traitement, et des décideurs dans la planification de programmes de lutte contre cette pathologie. PMID:28292037

  20. Polymorphisme de l'apolipoprotéine E dans la population du nord du Maroc: fréquence et influence sur les paramètres lipidiques

    PubMed Central

    Benyahya, Fatiha; Barakat, Amina; Ghailani, Naima; Bennani, Mohcine

    2013-01-01

    Introduction L'objectif de ce travail est de déterminer les fréquences alléliques et génotypiques des sites polymorphes situés dans le gène de l'apolipoprotéine E (apo E) ainsi que leur impact sur les paramètres cliniques et lipidiques dans un échantillon de la population du nord du Maroc cliniquement diagnostiqué ADH. Méthodes Le génotype de l'apo E a été analysé par séquençage direct chez 46 patients cliniquement diagnostiqués ADH selon les critères standards. Résultats Les fréquences des allèles epsilon 3, epsilon 2 et epsilon 4 ont été respectivement 78.3%, 2.2% et 19.6%. La fréquence de l'allèle epsilon 4 est très élevée chez la population du nord du Maroc en comparaison avec les populations des autres régions marocaines. Elle est similaire à celle rapportée dans les pays de l'Europe du nord. Les taux du cholestérol total, du cholestérol LDL ainsi que la présence des xanthomes et les maladies cardiovasculaires ne différent pas entre les génotypes de l'apoE. En revanche, les résultats ont montré une influence de l'allèle epsilon4 sur le taux des triglycérides chez les sujets obèses. Conclusion Le génotype de l'apoE ne peut expliquer le phénotype clinique et biochimique présenté par des patients du Nord du Maroc cliniquement diagnostiqués ADH. PMID:24396563

  1. Lifelong obesity in a polygenic mouse model prevents age- and diet-induced glucose intolerance- obesity is no road to late-onset diabetes in mice.

    PubMed

    Renne, Ulla; Langhammer, Martina; Brenmoehl, Julia; Walz, Christina; Zeissler, Anja; Tuchscherer, Armin; Piechotta, Marion; Wiesner, Rudolf J; Bielohuby, Maximilian; Hoeflich, Andreas

    2013-01-01

    Visceral obesity holds a central position in the concept of the metabolic syndrome characterized by glucose intolerance in humans. However, until now it is unclear if obesity by itself is responsible for the development of glucose intolerance. We have used a novel polygenic mouse model characterized by genetically fixed obesity (DU6) and addressed age- and high fat diet-dependent glucose tolerance. Phenotype selection over 146 generations increased body weight by about 2.7-fold in male 12-week DU6 mice (P<0.0001) if compared to unselected controls (Fzt:DU). Absolute epididymal fat mass was particularly responsive to weight selection and increased by more than 5-fold (P<0.0001) in male DU6 mice. At an age of 6 weeks DU6 mice consumed about twice as much food if compared to unselected controls (P<0.001). Absolute food consumption was higher at all time points measured in DU6 mice than in Fzt:DU mice. Between 6 and 12 weeks of age, absolute food intake was reduced by 15% in DU6 mice (P<0.001) but not in Fzt:DU mice. In both mouse lines feeding of the high fat diet elevated body mass if compared to the control diet (P<0.05). In contrast to controls, DU6 mice did not display high fat diet-induced increases of epididymal and renal fat. Control mice progressively developed glucose intolerance with advancing age and even more in response to the high fat diet. In contrast, obese DU6 mice did neither develop a glucose intolerant phenotype with progressive age nor when challenged with a high fat diet. Our results from a polygenic mouse model demonstrate that genetically pre-determined and life-long obesity is no precondition of glucose intolerance later in life.

  2. Investigation de l'anisotropie du gap supraconducteur dans les composes Ba(Fe(1-x)Co(x))2As2, Ba(1-x)K(x)Fe2As2, LiFeAs et Fe1-deltaTe(1-x)Se(x)

    NASA Astrophysics Data System (ADS)

    Reid, Jean-Philippe

    ommaire La structure du gap supraconducteur et sa modulation sont intimement liees au potentiel d'interaction responsable de l'appariement des electrons d'un supraconducteur. Ainsi, l'etude de la structure du gap-SC et de sa modulation permettent de faire la lumiere sur la nature du mecanisme d'appariement des electrons. A cet egard, les resultats experimentaux des supraconducteurs a base de fer ne cadrent pas dans un seul ensemble, ce qui est en opposition au gap-SC universel des cuprates. Dans ce qui suit, nous presenterons une etude systematique du gap-SC pour plusieurs pnictides. En effet, en utilisant la conductivite thermique, une sonde directionnelle du gap-SC, nous avons ete en mesure de reveler la structure du gap-SC pour les composes suivants : Ba1-xKxFe 2As2, Ba(Fe1-xCo x)2As2, LiFeAs et Fe1-deltaTe 1-xSex. L'etude de ces quatre composes, de trois differentes familles structurales, a pu etablir un tableau partiel mais tres exhaustif de la structure du gap-SC de pnictides. En effet, tel qu'illustre dans cette these, ces quatre composes ne possedent aucun noeud dans leur structure du gap-SC a dopage optimal. Toutefois, a une concentration differente de celle optimale pour les composes K-Ba122 et Co-Ba122, des noeuds apparaissent sur la surface de Fermi, aux extremites 'du dome supraconducteur. Ceci suggere fortement que, pour ces composes, la presence de noeuds sur la surface de Fermi est nuisible a la phase supraconductrice. Mots-cles: Supraconducteurs a base de fer, Pnictides, Structure du gap supraconducteur, Conductivite thermique

  3. Properties, use and health effects of depleted uranium (DU): a general overview.

    PubMed

    Bleise, A; Danesi, P R; Burkart, W

    2003-01-01

    Depleted uranium (DU), a waste product of uranium enrichment, has several civilian and military applications. It was used as armor-piercing ammunition in international military conflicts and was claimed to contribute to health problems, known as the Gulf War Syndrome and recently as the Balkan Syndrome. This led to renewed efforts to assess the environmental consequences and the health impact of the use of DU. The radiological and chemical properties of DU can be compared to those of natural uranium, which is ubiquitously present in soil at a typical concentration of 3 mg/kg. Natural uranium has the same chemotoxicity, but its radiotoxicity is 60% higher. Due to the low specific radioactivity and the dominance of alpha-radiation no acute risk is attributed to external exposure to DU. The major risk is DU dust, generated when DU ammunition hits hard targets. Depending on aerosol speciation, inhalation may lead to a protracted exposure of the lung and other organs. After deposition on the ground, resuspension can take place if the DU containing particle size is sufficiently small. However, transfer to drinking water or locally produced food has little potential to lead to significant exposures to DU. Since poor solubility of uranium compounds and lack of information on speciation precludes the use of radioecological models for exposure assessment, biomonitoring has to be used for assessing exposed persons. Urine, feces, hair and nails record recent exposures to DU. With the exception of crews of military vehicles having been hit by DU penetrators, no body burdens above the range of values for natural uranium have been found. Therefore, observable health effects are not expected and residual cancer risk estimates have to be based on theoretical considerations. They appear to be very minor for all post-conflict situations, i.e. a fraction of those expected from natural radiation.

  4. Chemical toxicity and radioactivity of depleted uranium: The evidence from in vivo and in vitro studies.

    PubMed

    Asic, Adna; Kurtovic-Kozaric, Amina; Besic, Larisa; Mehinovic, Lejla; Hasic, Azra; Kozaric, Mirza; Hukic, Mirsada; Marjanovic, Damir

    2017-07-01

    The main aim of this review is to summarize and discuss the current state of knowledge on chemical toxicity and radioactivity of depleted uranium (DU) and their effect on living systems and cell lines. This was done by presenting a summary of previous investigations conducted on different mammalian body systems and cell cultures in terms of potential changes caused by either chemical toxicity or radioactivity of DU. In addition, the authors aimed to point out the limitations of those studies and possible future directions. The majority of both in vitro and in vivo studies performed using animal models regarding possible effects caused by acute or chronic DU exposure has been reviewed. Furthermore, exposure time and dose, DU particle solubility, and uranium isotopes as factors affecting the extent of DU effects have been discussed. Special attention has been dedicated to chromosomal aberrations, DNA damage and DNA breaks, as well as micronuclei formation and epigenetic changes, as DU has recently been considered a possible causative factor of all these processes. Therefore, this approach might represent a novel area of study of DU-related irradiation effects on health. Since different studies offer contradictory results, the main aim of this review is to summarize and briefly discuss previously obtained results in order to identify the current opinion on DU toxicity and radioactivity effects in relation to exposure type and duration, as well as DU properties. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. NATO Human Resources (Manpower) Management (Gestion des ressources humaines (effectifs) de l’OTAN)

    DTIC Science & Technology

    2012-02-01

    performances , la gestion des récompenses et du salaire, et la motivation du personnel. En conséquence, il faut que la gestion des ressources humaines...importance au fil du temps. Les ressources humaines, chargées à l’origine de l’embauche, du licenciement, de la paie et de la gestion des ...les effets des systèmes d’évaluation des performances ;

  6. The Seamless Maritime Concept

    DTIC Science & Technology

    2005-03-01

    example demonstrating both the power and profitability of this strategy is the Cirque du Soleil . The Cirque du Soleil is a result of the effort to...ballet, and recognizing the value of the strengths of each and leveraging those strengths into a new market. The Cirque du Soleil is a dramatic...reduce the production costs and over head associated with running a circus, improve the entertainment value, and create a new market. Cirque du

  7. W.E.B. Du Bois and Caste Education: Racial Capitalist Schooling from Reconstruction to Jim Crow

    ERIC Educational Resources Information Center

    Pierce, Clayton

    2017-01-01

    This essay provides the first account and examination of caste education in the work of W.E.B. Du Bois. In so doing, I argue that caste education plays a central role in realizing the political and social goals of racial capitalist society for Du Bois. Using Du Bois's caste analytic, I take up and articulate three biopolitical governing strategies…

  8. Ecological risk assessment of depleted uranium in the environment at Aberdeen Proving Ground

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Clements, W.H.; Kennedy, P.L.; Myers, O.B.

    1993-01-01

    A preliminary ecological risk assessment was conducted to evaluate the effects of depleted uranium (DU) in the Aberdeen Proving Ground (APG) ecosystem and its potential for human health effects. An ecological risk assessment of DU should include the processes of hazard identification, dose-response assessment, exposure assessment, and risk characterization. Ecological risk assessments also should explicitly examine risks incurred by nonhuman as well as human populations, because risk assessments based only on human health do not always protect other species. To begin to assess the potential ecological risk of DU release to the environment we modeled DU transport through the principalmore » components of the aquatic ecosystem at APG. We focused on the APG aquatic system because of the close proximity of the Chesapeake Bay and concerns about potential impacts on this ecosystem. Our objective in using a model to estimate environmental fate of DU is to ultimately reduce the uncertainty about predicted ecological risks due to DU from APG. The model functions to summarize information on the structure and functional properties of the APG aquatic system, to provide an exposure assessment by estimating the fate of DU in the environment, and to evaluate the sources of uncertainty about DU transport.« less

  9. Ecological risk assessment of depleted uranium in the environment at Aberdeen Proving Ground. Annual report, 1991

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Clements, W.H.; Kennedy, P.L.; Myers, O.B.

    1993-03-01

    A preliminary ecological risk assessment was conducted to evaluate the effects of depleted uranium (DU) in the Aberdeen Proving Ground (APG) ecosystem and its potential for human health effects. An ecological risk assessment of DU should include the processes of hazard identification, dose-response assessment, exposure assessment, and risk characterization. Ecological risk assessments also should explicitly examine risks incurred by nonhuman as well as human populations, because risk assessments based only on human health do not always protect other species. To begin to assess the potential ecological risk of DU release to the environment we modeled DU transport through the principalmore » components of the aquatic ecosystem at APG. We focused on the APG aquatic system because of the close proximity of the Chesapeake Bay and concerns about potential impacts on this ecosystem. Our objective in using a model to estimate environmental fate of DU is to ultimately reduce the uncertainty about predicted ecological risks due to DU from APG. The model functions to summarize information on the structure and functional properties of the APG aquatic system, to provide an exposure assessment by estimating the fate of DU in the environment, and to evaluate the sources of uncertainty about DU transport.« less

  10. Molecular characterization of allelic variants of (GATA)n microsatellite loci in parthenogenetic lizards Darevskia unisexualis (Lacertidae).

    PubMed

    Korchagin, V I; Badaeva, T N; Tokarskaya, O N; Martirosyan, I A; Darevsky, I S; Ryskov, A P

    2007-05-01

    Populations of parthenogenetic lizards of the genus Darevskia consist of genetically identical animals, and represent a unique model for studying the molecular mechanisms underlying the variability and evolution of hypervariable DNA repeats. As unisexual lineages, parthenogenetic lizards are characterized by some level of genetic diversity at microsatellite loci. We cloned and sequenced a number of (GATA)n microsatellite loci of Darevskia unisexualis. PCR products from these loci were also sequenced and the degree of intraspecific polymorphism was assessed. Among the five (GATA)n loci analysed, two (Du215 and Du281) were polymorphic. Cross-species analysis of Du215 and Du281 indicate that the priming sites at the D. unisexualis loci are conserved in the bisexual parental species, D. raddei and D. valentini. Sequencing the PCR products amplified from Du215 and Du281 and from monomorphic Du323 showed that allelic differences at the polymorphic loci are caused by microsatellite mutations and by point mutations in the flanking regions. The haplotypes identified among the allelic variants of Du281 and among its orthologues in the parental species provide new evidence of the cross-species origin of D. unisexualis. To our knowledge, these data are the first to characterize the nucleotide sequences of allelic variants at microsatellite loci within parthenogenetic vertebrate animals.

  11. Molecular cloning and functional characterization of duck nucleotide-binding oligomerization domain 1 (NOD1).

    PubMed

    Li, Huilin; Jin, Hui; Li, Yaqian; Liu, Dejian; Foda, Mohamed Frahat; Jiang, Yunbo; Luo, Rui

    2017-09-01

    Nucleotide-binding oligomerization domain 1 (NOD1) is an imperative cytoplasmic pattern recognition receptor (PRR) and considered as a key member of the NOD-like receptor (NLR) family which plays a critical role in innate immunity through sensing microbial components derived from bacterial peptidoglycan. In the current study, the full-length of duck NOD1 (duNOD1) cDNA from duck embryo fibroblasts (DEFs) was cloned. Multiple sequence alignment and phylogenetic analysis demonstrated that duNOD1 exhibited a strong evolutionary relationship with chicken and rock pigeon NOD1. Tissue-specific expression analysis showed that duNOD1 was widely distributed in various organs, with the highest expression observed in the liver. Furthermore, duNOD1 overexpression induced NF-κB activation in DEFs and the CARD domain is crucial for duNOD1-mediated NF-κB activation. In addition, silencing the duNOD1 decreased the activity of NF-κB in DEFs stimulated by iE-DAP. Overexpression of duNOD1 significantly increased the expression of TNF-α, IL-6, and RANTES in DEFs. These findings highlight the crucial role of duNOD1 as an intracellular sensor in duck innate immune system. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Portage vaginal du streptocoque du groupe B chez la femme enceinte au niveau de la région de Marrakech

    PubMed Central

    Bassir, Ahlam; Dhibou, Hanane; Farah, Majdi; Mohamed, Lharmis; Amal, Addebous; Nabila, Souraa; Abderahim, Aboulfalah; Asmouki, Hamid; Soummani, Abderraouf

    2016-01-01

    Introduction Le streptocoque du groupe B est le principal agent impliqué dans les infections materno-fœtales, les septicémies et les méningites du nouveau-né à terme. L'objectif est de déterminer le taux de portage maternel du streptocoque du groupe B (SGB) à terme. Méthodes Un prélèvement vaginal a été réalisé de manière prospective chez 275 parturientes lors de l'entrée en salle d'accouchement sur une période de 06 mois. Résultats Le taux de portage était de 20,2%. Le portage était variable en fonction de l’âge gestationnel, il constitue 57.5% entre 37 et 38 semaines d'aménorrhée. Aucun des facteurs de risque n'a était statistiquement prédictif du portage maternel du SGB. Conclusion Le dépistage doit être réalisé à partir de 37 semaines d'aménorrhée, et comme le portage est intermittent, un prélèvement négatif ne garantirait pas que le portage soit négatif à l'accouchement. PMID:27222693

  13. Guideline on Scenario Development for (Distributed) Simulation Environments (Guide en vue du developpement de scenario dans le cadre de simulation distribuee)

    DTIC Science & Technology

    2015-01-01

    des lacunes de M&S du MORS du NMSG a déterminé que le manque d’interopérabilité de la simulation constituait la lacune prioritaire à combler en...matière de capacité, une équipe exploratoire (ET-027) a été constituée au sein du NMSG pour étudier l’interopérabilité de la simulation. L’ET-027 a...élevés (autrement dit, aux niveaux pratique, dynamique et conceptuel) de même que l’automatisation relative du développement, de

  14. Microeconomics and Psychology

    ERIC Educational Resources Information Center

    Beckman, Steven; Chen, Lanxin; DeAngelo, Greg; Smith, W. James; Zhang, Xieting

    2011-01-01

    Psychologists such as the Nobel Prize-winner Daniel Kahneman challenge the major assumptions of microeconomics: the rational pursuit of self-interest given unchanging tastes. One may explore these issues through a questionnaire that may be distributed in class. How many of your students behave as the psychologists predict? Should economists adapt…

  15. The Case, If Any, for Economic Literacy.

    ERIC Educational Resources Information Center

    Stigler, George J.

    1983-01-01

    This article, which first appeared in the Spring 1970 issue of the "Journal of Economic Education," is reprinted as a tribute to Nobel Memorial Prize winner Stigler with the expectation that it will provoke current discussion about the goals and accomplishments of the economic education movement. (Author/RM)

  16. Scientific Cooperation and Human Rights: An East-West Exchange of Views.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1979

    1979-01-01

    Presents a translation of an article written by five members of the Soviet Academy of Sciences on the US-Soviet scientific cooperation and human rights. An open letter written by five American Nobel laureates as a rebuttal to this article is also presented. (HM)

  17. Choices for Science. Symposium Proceedings. Bunting Institute Working Paper.

    ERIC Educational Resources Information Center

    Radcliffe Coll., Cambridge, MA. Mary Ingraham Bunting Inst.

    These proceedings result from a symposium designed to provide a forum for the consideration of major social issues confronting science today. Participants (including scientists at different stages of career development from undergraduate concentrator to Nobel laureate) discussed issues related to the scientist's responsibilities as scientist and…

  18. Computer Intelligence: Unlimited and Untapped.

    ERIC Educational Resources Information Center

    Staples, Betsy

    1983-01-01

    Herbert Simon (Nobel prize-winning economist/professor) expresses his views on human and artificial intelligence, problem solving, inventing concepts, and the future. Includes comments on expert systems, state of the art in artificial intelligence, robotics, and "Bacon," a computer program that finds scientific laws hidden in raw data.…

  19. The Blue LED Nobel Prize: Historical context, current scientific understanding, human benefit

    DOE PAGES

    Tsao, Jeffrey Y.; Han, Jung; Haitz, Roland H.; ...

    2015-06-19

    Here, the paths that connect scientific understanding with tools and technology are rarely linear. Sometimes scientific understanding leads and enables, sometimes tools and technologies lead and enable. But by feeding on each other, they create virtuous spirals of forward and backward innovation.

  20. The Blue LED Nobel Prize: Historical context, current scientific understanding, human benefit

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tsao, Jeffrey Y.; Han, Jung; Haitz, Roland H.

    Here, the paths that connect scientific understanding with tools and technology are rarely linear. Sometimes scientific understanding leads and enables, sometimes tools and technologies lead and enable. But by feeding on each other, they create virtuous spirals of forward and backward innovation.

  1. Secretory products of macrophages: twenty-five years on.

    PubMed

    Nathan, Carl

    2012-04-01

    No longer do scientists look down on macrophages as "garbage men" that act "nonspecifically." Last fall's Nobel Prizes honored two of the few scientists who studied macrophages three decades ago. Now perhaps thousands do, and the subtypes they describe reflect ongoing discoveries of macrophages' extraordinary plasticity.

  2. The Dispute over Nuclear Fission.

    ERIC Educational Resources Information Center

    Sime, Ruth Lewin

    1996-01-01

    Reveals the stormy relationship and ongoing controversy surrounding the scientific collaboration of Otto Hahn and Lise Meitner. Discusses the controversial 1944 Nobel Prize award to Hahn (ignoring the equal contribution of Meitner), the reaction of the scientific community, and the post-war years of both Meitner and Hahn. (MJP)

  3. Q&A: Boson beginnings

    NASA Astrophysics Data System (ADS)

    Daphney Bucher, Thifhelimbilu

    2015-10-01

    François Englert shared the 2013 Nobel Prize in Physics with Peter Higgs for the theoretical discovery of a mechanism that gives mass to subatomic particles. For this work, he collaborated with Robert Brout, who died in 2011. He looks back on his contribution to science with Thifhelimbilu Daphney Bucher.

  4. Profile of a Peace Historian: Irwin Abrams.

    ERIC Educational Resources Information Center

    OAH Magazine of History, 1994

    1994-01-01

    Discusses the significance of Irwin Abrams to the field of peace history. Describes Abrams' personal life, his work with the American Friends Service Committee, his scholarly work, and his leadership in peace history. Concludes by discussing his research on the Nobel Peace Prize and its recipients. (CFR)

  5. Nex-Gen Space Observatory

    NASA Image and Video Library

    2011-10-26

    Adam Reiss, recipient of the 2011 Nobel Prize in Physics and professor of astronomy and physics at Johns Hopkins University speaks at the presentation of the permanent exhibit of the James Webb Space Telescope at the Maryland Science Center on Wednesday, Oct. 26, 2011 in Baltimore. Photo Credit: (NASA/Carla Cioffi)

  6. Good scientists and honest people

    NASA Astrophysics Data System (ADS)

    Robinson, Andrew

    2014-06-01

    In early 1948, less than three years after the end of the Second World War in Europe, Werner Heisenberg - the Nobel laureate and physicist leader of the failed German atomic bomb project - was invited to the UK as part of an attempt to repair relations between British and German physicists.

  7. Western Dilemma

    ScienceCinema

    None

    2017-12-09

    L'association du personnel présente Anthony Sampson, écrivain connu dans le monde entier par ses nombreux ouvrages et publications (International Harold Tribune, Observer, News Week). Il nous parle du commerce des armes et du Moyen Orient.

  8. Nobel Prize In Physics Awarded To Astronomer For NASA-Funded Research

    NASA Astrophysics Data System (ADS)

    2002-10-01

    Riccardo Giacconi, the "father of X-ray astronomy," has received the Nobel Prize in physics for "pioneering contributions to astrophysics," which have led to the discovery of cosmic X-ray sources. Giaconni, president of the Associated Universities Inc., in Washington, and Research Professor of Physics and Astronomy at Johns Hopkins University, Baltimore, discovered the first X-ray stars and the X-ray background in the 1960s and conceived of and led the implementation of the Uhuru and High Energy Astronomy Observatory-2 (HEAO-2) X-ray observatories in the 1970s. With funding from NASA, he also detected sources of X-rays that most astronomers now consider to contain black holes. Giacconi said that receiving the award confirms the importance of X-ray astronomy. "I think I'm one of the first to get the Nobel prize for work with NASA, so that's good for NASA and I think it's also good for the field," he said. "It's also nice for all the other people who've worked in this field. I recognize that I was never alone. I'm happy for me personally, I'm happy for my family, and I'm happy for the field and for NASA," Giacconi added. In 1976, Giacconi along with Harvey Tananbaum of the Harvard- Smithsonian Center for Astrophysics, Cambridge, Mass., submitted a proposal letter to NASA to initiate the study and design of a large X-ray telescope. In 1977 work began on the program, which was then known as the Advanced X-ray Astrophysics Facility and in 1998 renamed the Chandra X-ray Observatory. "Partnerships with universities and scientists are essential in our quest to answer the fundamental questions of the universe," said Dr. Ed Weiler, NASA Associate Administrator for Space Science, Headquarters, Washington. "Dr. Giacconi's achievements are a brilliant example of this synergy among NASA, universities and their community of scientists and students," he said. Giacconi is Principal Investigator for the ultradeep survey with Chandra - the "Chandra Deep Field South" - that has already obtained the deepest X-ray exposures to date with a million-second observation. He was also the first director of the Hubble Space Telescope Science Institute in Baltimore. Giacconi, 71, received half the prize. Raymond Davis Jr., 87, of the University of Pennsylvania and Masatoshi Koshiba, 76, of the University of Tokyo will share the other half of the prize, worth about $1 million, for their research into cosmic neutrinos. For more information visit: http://nobelprize.org/ Chandra Chronicles: A High-Energy Visonary Wins Nobel Prize

  9. Kyste hydatique mammaire primitive

    PubMed Central

    Boufettal, Houssine; Samouh, Naïma

    2015-01-01

    La localisation mammaire du kyste hydatique est exceptionnelle. De ce fait, le diagnostic est difficile avant l'examen anatomopathologique. Nous rapportons une observation d'un cas de kyste hydatique du sein chez une femme de 32 ans, qui consultait pour un nodule du sein, dont l'imagerie montrait une lésion en rétro-aréolaire du sein gauche, homogène, ovalaire et de contours réguliers. L'examen anatomopathologique objectivait un kyste hydatique à localisation mammaire. Les suites opératoires étaient simples. L'hydatidose est une maladie ubiquitaire, pouvant atteindre tous les organes. Le diagnostic peut être évoqué devant une masse kystique du sein avec des aspects très évocateurs à l'imagerie. La confirmation du diagnostic n'est confirmée qu'après une cytoponction ou une chirurgie d'exérèse qui réalise le traitement de cette pathologique. La négativité du bilan d'extension hydatique permet de retenir une localisation primitive de l’échinococcose. PMID:26185575

  10. Etude de l'affaiblissement du comportement mecanique du pergelisol du au rechauffement climatique

    NASA Astrophysics Data System (ADS)

    Buteau, Sylvie

    Le rechauffement climatique predit pour les prochaines decennies, aura des impacts majeurs sur le pergelisol qui sont tres peu documentes pour l'instant. La presente etude a pour but d'evaluer ces impacts sur les proprietes mecaniques du pergelisol et sa stabilite a long terme. Une nouvelle technique d'essai de penetration au cone a taux de deformation controle, a ete developpee pour caracteriser en place le pergelisol. Ces essais geotechniques et la mesure de differentes proprietes physiques ont ete effectues sur une butte de pergelisol au cours du printemps 2000. Le developpement et l'utilisation d'un modele geothermique 1D tenant compte de la thermodependance du comportement mecanique ont permis d'evaluer que les etendues de pergelisol chaud deviendraient instables a la suite d'un rechauffement de l'ordre de 5°C sur cent ans. En effet, la resistance mecanique du pergelisol diminuera alors rapidement jusqu'a 11,6 MPa, ce qui correspond a une perte relative de 98% de la resistance par rapport a un scenario sans rechauffement.

  11. [Effects of overexpression of miR-17-92 gene cluster on the biological characteristics of prostate cancer cells and its mechanism].

    PubMed

    Zhou, P; Ma, L; Zhou, J; Xu, J J; Liu, F; Guo, F

    2017-05-23

    Objective: To explore the effect and mechanism of over-expression of miR-17-92 gene cluster on the biological characteristics of prostate cancer cells. Methods: DU145 cells were transfected with miR-17-92 gene expression plasmid and clones with stable ectopic miR-17-92 overexpression were established. The cell viabilities of DU145-17-92 and DU145-control cells were monitored by xCELLigence system. Cell proliferation and apoptosis were analyzed by Ki-67 and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Cell cycle was detected by flow cytometry. Expression levels of proteins involved in apoptosis and Akt pathway were determined by western blotting. Results: xCELLigence RTCA array data showed that the growth rate of DU145-17-92 cells was significantly higher than that of DU145-control cells after 24 h of seeding ( P <0.01). The Ki-67-positive rates of the DU145-control group at 24, 48 and 72 hours were (56.57±1.68)%, (85.48±0.26)% and (90.85±2.08)%, respectively. While the Ki-67 positive rates of the DU145-17-92 group at the desired time points were (73.64±0.68)%, (93.43±1.23)% and (97.36±0.86)%, respectively, with a statistically significant difference at 24 hours ( P <0.01). The percentages of apoptotic cells of the DU145-control group at 24, 48 and 72 hours were (6.76±0.09)%, (14.51±0.86)% and (20.73±1.64)%, respectively, while the apoptotic percentages of the DU145-17-92 group were (1.86±0.15)%, (7.90±0.40)% and (4.92±0.48)%, respectively. The percentages of apoptotic cells of the DU145-control group at different time were significantly higher than those of DU145-17-92 group ( P <0.01 for all). The result of western blotting showed that the protein expression levels of Bcl-2 interacting mediator of cell death (BIM) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in DU145-control cells were 0.83±0.00 and 0.91±0.00, respectively, significantly higher than 0.16±0.00 and 0.13±0.00 of DU145-17-92 cells (both P <0.01). Overexpression of miR17-92 induced the phosphorylation of protein kinase B (Akt) at Ser473 while no appreciable effect on the phosphorylation of Akt at Thr308. The phosphorylated level of extracellular regulated protein kinases (ERK) in DU145-control cells was 0.21±0.01, significantly lower than 0.72±0.01 of DU145-17-92 cells ( P <0.01). Conclusions: Overexpression of miR-17-92 gene plays a pivotal role in growth, proliferation, apoptosis and cell cycle of DU145 cells through down-regulation of apoptotic protein BIM and tumor suppressor PTEN and activation of Akt and ERK signaling pathway.

  12. Séroprévalence et facteurs associés à l’acceptation du Conseil et Dépistage Volontaire du VIH chez l’enfant à Lubumbashi, République Démocratique du Congo

    PubMed Central

    Ngwej, Dieudonné Tshikwej; Mukuku, Olivier; Malonga, Françoise Kaj; Luboya, Oscar Numbi; Kakoma, Jean-Baptiste Sakatolo; Wembonyama, Stanis Okitotsho

    2017-01-01

    Résumé Introduction Malgré le dépistage du VIH proposé lors de la naissance ou au cours des consultations préscolaires, la proportion des enfants qui croissent ou décèdent sous statut sérologique au VIH inconnu est importante en République Démocratique du Congo (RDC). L’objectif de cette étude était de déterminer la séroprévalence au cours d’un dépistage volontaire et d’identifier les facteurs associés à l’acceptation du conseil et dépistage du VIH (CDV) en dehors de la maladie ou de toute exposition au VIH dans une population pédiatrique à Lubumbashi, RDC. Méthodes Il s’agissait d’une étude prospective transversale à visée analytique menée du 1er août 2006 au 31 septembre 2007. Elle avait été réalisée dans 4 centres communautaires de CDV répartis dans 4 zones de santé de la ville de Lubumbashi en RDC (Lubumbashi, Ruashi, Kampemba et de Kenya). L’étude avait consisté à faire le dépistage volontaire du VIH chez les enfants de moins de 15 ans. Les caractéristiques sociodémographiques et les paramètres relatifs au conseil et dépistage volontaire ont été étudiés. Les analyses statistiques descriptives usuelles et une régression logistique ont été réalisées. Résultats Sur 463 enfants dépistés du VIH, 41 (8,9%; IC 95%: 6,5%-11,9%) ont été testés positifs. L’acceptation du conseil et dépistage volontaire du VIH en dehors de la maladie ou de l’exposition au VIH était significativement plus élevée lorsque l’enfant était âgé de plus de 2 ans (Odds ratio ajusté (ORa) = 3,6 [IC 95%: 1,1-12,2]), lorsque le statut sérologique du VIH des parents était négatif ou inconnu (ORa = 27,4 [IC 95%: 9,4-80,0]), lorsque l’un ou l’autre ou les deux parents biologiques étaient en vie (ORa = 24,9 [IC 95%: 2,4-250,8]) et lorsque la connaissance du lieu de dépistage était fait par des moyens autres que le professionnel de santé (ORa = 2,9 [IC 95%: 1,0-7,9]). Conclusion Notre étude montre une forte prévalence du VIH chez les enfants justifiant la nécessité de réaliser le CDV qui est significativement accepté par leurs parents et tuteurs dans la ville de Lubumbashi. PMID:29255552

  13. Chemours Pompton Lakes Works Site, Pompton Lakes, NJ

    EPA Pesticide Factsheets

    E.I. DuPont De Nemours & Company is located at 2000 Cannonball Road, Pompton Lakes, New Jersey. The DuPont Pompton Lakes Works site (DuPont) occupies approximately 570 acres of land in Pompton Lakes and Wanaque.

  14. La reconstruction du sourcil par greffon composite du cuir chevelu: une astuce pour faciliter la technique

    PubMed Central

    El Omari, Mounia; El Mazouz, Samir; Gharib, Noureddine; EL Abbassi, Abdallah

    2015-01-01

    Les sourcils jouent un rôle important dans l’équilibre esthétique du visage. Leur reconstruction ou ophriopoïése, après séquelle de brûlure fait partie intégrante du programme de réhabilitation de la face brûlée. Plusieurs techniques ont été décrites. Nous insistons ici sur l'intérêt d'une technique simple, à la portée de tous les chirurgiens, et dont la méthode et les résultats peuvent être améliorés par un dessin bien planifié des zones donneuse et receveuse: la greffe composite prélevée au niveau du cuir chevelu dessinée à l'aide d'un calque du sourcil controlatéral. PMID:26401195

  15. In Vivo Detection of Hyperoxia-Induced Pulmonary Endothelial Cell Death Using 99mTc-Duramycin

    PubMed Central

    Audi, Said H.; Jacobs, Elizabeth R.; Zhao, Ming; Roerig, David L.; Haworth, Steven T.; Clough, Anne V.

    2014-01-01

    Introduction: 99mTc-duramycin, DU, is a SPECT biomarker of tissue injury identifying cell death. The objective of this study is to investigate the potential of DU imaging to quantify capillary endothelial cell death in rat lung injury resulting from hyperoxia exposure as a model of acute lung injury. Methods: Rats were exposed to room air (normoxic) or >98% O2 for 48 or 60 hours. DU was injected i.v. in anesthetized rats, scintigraphy images were acquired at steady-state, and lung DU uptake was quantified from the images. Post-mortem, the lungs were removed for histological studies. Sequential lung sections were immunostained for caspase activation and endothelial and epithelial cells. Results: Lung DU uptake increased significantly (p < 0.001) by 39% and 146% in 48-hr and 60-hr exposed rats, respectively, compared to normoxic rats. There was strong correlation (r2 = 0.82, p = 0.005) between lung DU uptake and the number of cleaved caspase 3 (CC3) positive cells, and endothelial cells accounted for more than 50% of CC3 positive cells in the hyperoxic lungs. Histology revealed preserved lung morphology through 48 hours. By 60 hours there was evidence of edema, and modest neutrophilic infiltrate. Conclusions: Rat lung DU uptake in vivo increased after just 48 hours of >98% O2 exposure, prior to the onset of any substantial evidence of lung injury. These results suggest that apoptotic endothelial cells are the primary contributors to the enhanced DU lung uptake, and support the utility of DU imaging for detecting early endothelial cell death in vivo. PMID:25218023

  16. Teratogenicity of depleted uranium aerosols: A review from an epidemiological perspective

    PubMed Central

    Hindin, Rita; Brugge, Doug; Panikkar, Bindu

    2005-01-01

    Background Depleted uranium is being used increasingly often as a component of munitions in military conflicts. Military personnel, civilians and the DU munitions producers are being exposed to the DU aerosols that are generated. Methods We reviewed toxicological data on both natural and depleted uranium. We included peer reviewed studies and gray literature on birth malformations due to natural and depleted uranium. Our approach was to assess the "weight of evidence" with respect to teratogenicity of depleted uranium. Results Animal studies firmly support the possibility that DU is a teratogen. While the detailed pathways by which environmental DU can be internalized and reach reproductive cells are not yet fully elucidated, again, the evidence supports plausibility. To date, human epidemiological data include case examples, disease registry records, a case-control study and prospective longitudinal studies. Discussion The two most significant challenges to establishing a causal pathway between (human) parental DU exposure and the birth of offspring with defects are: i) distinguishing the role of DU from that of exposure to other potential teratogens; ii) documentation on the individual level of extent of parental DU exposure. Studies that use biomarkers, none yet reported, can help address the latter challenge. Thoughtful triangulation of the results of multiple studies (epidemiological and other) of DU teratogenicity contributes to disentangling the roles of various potentially teratogenic parental exposures. This paper is just such an endeavor. Conclusion In aggregate the human epidemiological evidence is consistent with increased risk of birth defects in offspring of persons exposed to DU. PMID:16124873

  17. Long-term fate of depleted uranium at Aberdeen and Yuma Proving Grounds

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ebinger, M.H.; Essington, E.H.; Gladney, E.S.

    1990-06-01

    The environmental fate of fragments of depleted uranium (DU) penetrators in soils and waters at Aberdeen Proving Ground (APG) and Yuma Proving Ground (YPG) is a concern to the Testing and Evaluation Command (TECOM) of the US Army. This report presents the information from preliminary soil and water samples that were collected from the humid woodlands of APG and the arid Sonoran Desert of YPG. Soil samples collected beneath a penetrator fragment of the firing range at APG showed approximately 12% DU by weight in the surface horizon and DU significantly above background to a depth of about 20 cm.more » Samples of surface water at APG showed U only at background levels, and bottom sediments showed background U levels but with isotopic ratios of DU instead of natural U. Soil samples beneath a penetrator fragment at YPG showed about 0.5% by weight U in the surface horizon, but only background concentrations and isotopic ratios of U between 8 and 20 cm depth. Results from this preliminary study indicate that DU at APG was redistributed primarily be dissolution and transport with water and possibly by migration of DU colloids or DU attached to small particles. Redistribution at YPG, however, was mainly due to erosion of DU fragments from the impact area and redeposition in washes that drain the area. Proposed work for FY90-FY92 includes additional field sampling, laboratory column studies, and the development of a computer model of DU redistribution at both sites. 39 refs., 11 figs., 5 tabs.« less

  18. Selection and life history traits of tebufenozide-resistant sugarcane borer (Lepidoptera: Crambidae).

    PubMed

    Akbar, W; Ottea, J A; Beuzelin, J M; Reagan, T E; Huang, F

    2008-12-01

    Varying susceptibility to tebufenozide was recorded in the sugarcane borer, Diatraea saccharalis (F.) (Lepidoptera: Crambidae), collected from Louisiana sugarcane locations with different selection pressures. Results from diet incorporation bioassays with tebufenozide indicated significant increases in LC50 (3.78-fold) and LC90 (7-fold) values for a colony from Duson (DU), an area with higher selection pressure, compared with a colony from Alexandria (ALEX), an area with no selection pressure. Differences were not detected in LC50 values among colonies from areas where use of tebufenozide was discontinued or rotated with other chemistries. Selections with tebufenozide of DU larvae over 12 generations resulted in a highly resistant colony (DU-R) with 27.1- and 83.3-fold increases in LC50 and LC90 values, respectively. Comparison of pupal weight, days to pupation, and emergence after exposure to an equitoxic (LC20) concentration of tebufenozide revealed a decrease in pupal weight (34 and 33% for males and females, respectively), and an increase in days to pupation (47 and 40% for males and females, respectively), and emergence (43 and 33% for males and females, respectively) for the DU-R colony compared with the parent DU colony. Fecundity of DU-R females decreased to 72 eggs per female compared with 180 (DU) and 261 (ALEX). Egg viability of the ALEX and DU colonies was 61 and 56%, respectively, whereas only 27% of eggs laid by females from the DU-R colony hatched. These results are discussed in terms of their practical implications for control of D. saccharalis in Louisiana sugarcane.

  19. Mise à jour sur le nouveau vaccin 9-valent pour la prévention du virus du papillome humain

    PubMed Central

    Yang, David Yi; Bracken, Keyna

    2016-01-01

    Résumé Objectif Informer les médecins de famille quant à l’efficacité, à l’innocuité, aux effets sur la santé publique et à la rentabilité du vaccin 9-valent contre le virus du papillome humain (VPH). Qualité des données Des articles pertinents publiés dans PubMed jusqu’en mai 2015 ont été examinés et analysés. La plupart des données citées sont de niveau I (essais randomisés et contrôlés et méta-analyses) ou de niveau II (études transversales, cas-témoins et épidémiologiques). Des rapports et recommandations du gouvernement sont aussi cités en référence. Message principal Le vaccin 9-valent contre le VPH, qui offre une protection contre les types 6, 11, 16, 18, 31, 33, 45, 52 et 58 du VPH, est sûr et efficace et réduira encore plus l’incidence des infections à VPH, de même que les cas de cancer lié au VPH. Il peut également protéger indirectement les personnes non immunisées par l’entremise du phénomène d’immunité collective. Un programme d’immunisation efficace peut prévenir la plupart des cancers du col de l’utérus. Les analyses montrent que la rentabilité du vaccin 9-valent chez les femmes est comparable à celle du vaccin quadrivalent original contre le VPH (qui protège contre les types 6, 11, 16 et 18 du VPH) en usage à l’heure actuelle. Toutefois, il faut investiguer plus en profondeur l’utilité d’immuniser les garçons avec le vaccin 9-valent contre le VPH. Conclusion en plus d’être sûr, le vaccin 9-valent protège mieux contre le VPH que le vaccin quadrivalent. Une analyse coûtefficacité en favorise l’emploi, du moins chez les adolescentes. Ainsi, les médecins devraient recommander le vaccin 9-valent à leurs patients plutôt que le vaccin quadrivalent contre le VPH.

  20. Pseudarthrose de l'extrémité inférieure du fémur traitée par mégaprothèse: à propos d'un cas et revue de la littérature

    PubMed Central

    Elidrissi, Mohammed; Hammou, Nassereddine; Shimi, Mohammed; Elibrahimi, Abdelhalim; Elmrini, Abdelmajid

    2013-01-01

    Les pseudarthroses de l'extrémité distale du fémur sont relativement rares du fait de la qualité de la vascularisation de cette région. La prise en charge d'une telle complication pose un certain nombre de difficultés. Le traitement chirurgical fait appel à plusieurs techniques conservatrices, le traitement par prothèse peut s'avérer utile quand la perte de substance est importante chez le sujet âgé. L'objectif de ce travail est de discuter l'intérêt de la mégaprothèse du genou dans le traitement de la pseudarthrose de l'extrémité distale du fémur, à travers l’étude de l'observation d'une patiente et revue de la littérature. Il s'agit d'une patiente âgée de 62 ans qui présente une pseudarthrose de l'extrémité distale du fémur gauche. Sur le plan clinique la patiente présente des douleurs du genou gauche, avec gène fonctionnelle importante. Le score de l'IKS préopératoire était de 60. Elle a bénéficié d'un remplacement prothétique par une mégaprothèse du genou. En postopératoire la flexion du genou était à 90°, le score de l'IKS était de 130. A travers l’étude de cette observation, et la revue de la littérature, nous pensons que l'utilisation de mégaprothèse du genou, constitue une solution efficace et durable pour le traitement des pseudarthroses du fémur distal et particulièrement chez le sujet âgé. Cette technique permet de répondre aux impératifs d'un tel aléa de la consolidation: lutter contre la douleur et garantir une mobilité satisfaisante permettant de répondre aux besoins de la vie quotidienne du patient et ainsi améliorer sa qualité de vie. PMID:24396555

  1. Analyse de L'ancrage des Vortex Intergrains pour le Yttrium BARYUM(2) CUIVRE(3) OXYGENE(7) Polycristallin

    NASA Astrophysics Data System (ADS)

    Fournier, Patrick

    Le Modele de l'Etat Critique Generalise (MECG) est utilise pour decrire les proprietes magnetiques et de transport du YBa_2Cu_3O _7 polycristallin. Ce modele empirique permet de relier la densite de courant critique a la densite de lignes de flux penetrant dans la region intergrain. Deux techniques de mesures sont utilisees pour caracteriser nos materiaux. La premiere consiste a mesurer le champ au centre d'un cylindre creux en fonction du champ magnetique applique pour des temperatures comprises entre 20 et 85K. En variant l'epaisseur de la paroi du cylindre creux, il est possible de suivre l'evolution des cycles d'hysteresis et de determiner des champs caracteristiques qui varient en fonction de cette dimension. En utilisant un lissage des resultats experimentaux, nous determinons J _{co}, H_ {o} et n, les parametres du MECG. La forme des cylindres, avec une longueur comparable au diametre externe, entrai ne la presence d'un champ demagnetisant qui peut etre inclus dans le modele theorique. Ceci nous permet d'evaluer la fraction du volume ecrante, f _{g}, ainsi que le facteur demagnetisant N. Nous trouvons que J_{ co}, H_{o} et f_{g} dependent de la temperature, tandis que n et N (pour une epaisseur de paroi fixe) n'en dependent pas. La deuxieme technique consiste a mesurer le courant critique de lames minces en fonction du champ applique pour differentes temperatures. Nous utilisons un montage que nous avons developpe permettant d'effectuer ces mesures en contact direct avec le liquide refrigerant, i.e. dans l'azote liquide. Nous varions la temperature du liquide en variant la pression du gaz au-dessus du bain d'azote. Cette methode nous permet de balayer des temperatures entre 65K et la temperature critique du materiau ({~ }92K). Nous effectuons le lissage des courbes de courant critique en fonction du champ applique encore a l'aide du MECG, pour a nouveau obtenir ses parametres. Pour trois echantillons avec des traitements thermiques differents, les parametres sont differents confirmant que la variation des proprietes macroscopiques de ces supraconducteurs est intimement reliee a la nature des jonctions entre les grains et de la surface des grains. L'oxygenation prolongee retablit les proprietes initiales des echantillons qui se sont degrades durant le recuit des contacts.

  2. Vitamin D and Influenza

    DTIC Science & Technology

    2008-07-01

    industrial absenteeism caused by colds and respiratory illness; days of missed work was reduced by 30%. (n=3031) Homes AD, et al. Industrial...greater than ~87nmol/L. Vitamin D from sunlight affects TB The 1903 Nobel prize was awarded for the discovery that vitamin D from sunlight could cure cutaneous TB….

  3. Richard Schrock, Robert Grubbs, and Metathesis Method in Organic Synthesis

    Science.gov Websites

    Organic Synthesis Resources with Additional Information Richard R. Schrock of the Massachusetts Institute Nobel Prize in Chemistry "for the development of the metathesis method in organic synthesis" ] Chauvin, Grubbs and Schrock "for the development of the metathesis method in organic synthesis,"

  4. Primary Schooling in West Bengal

    ERIC Educational Resources Information Center

    Sen, Amartya

    2010-01-01

    With his Nobel Prize award money, Amartya Sen set up the Pratichi Trust which carries out research, advocacy and experimental projects in basic education, primary health care, and women's development in West Bengal and Bangladesh. Professor Sen himself took active interest in this work--helping set the agenda, looking at the evidence from…

  5. Globalizing the English Curriculum through Caribbean Literature.

    ERIC Educational Resources Information Center

    Spoelman, Linda; Thomas, Katherine

    Although Caribbean (English) writers hold differing views on the effectiveness of making connections in an area of so much diversity, Caribbean literature can be connected to the English curriculum to promote diversity and understanding. V. S. Naipaul, Nobel Prize winning author from the region, presents a pessimistic view of Caribbean society in…

  6. An iconoclast's career

    NASA Astrophysics Data System (ADS)

    Anderson, Philip

    2013-03-01

    The "maverick genius" referred to in the title of Phillip Schewe's book is Freeman Dyson: a truly great mathematical physicist, bestselling author, longest-serving member of the US military's JASON advisory group, and occupant of the "fourth chair" when the Nobel Prize for Physics was awarded for quantum electrodynamics (QED) - among many other distinctions.

  7. Problem-Solving Test: Telomere Replication

    ERIC Educational Resources Information Center

    Szeberenyi, Jozsef

    2010-01-01

    The Nobel Prize in Physiology or Medicine in 2009 was awarded to Elizabeth H. Blackburn, Carol W. Greider, and Jack W. Szostak for the discovery of "how chromosomes are protected by telomeres and the enzyme telomerase." The discovery has important implications in the processes of cellular aging and carcinogenesis. Telomeres are satellite DNA…

  8. Home | University of Illinois Urbana-Champaign

    Science.gov Websites

    Students Faculty & Staff Alumni Parents Campus Resources The Next 150 Strategic Plan Inclusive Illinois Search Directory Quicklinks A-Z Index & Directory Map Library Give Now Resources for Students Faculty & Staff Alumni Parents About About Links Overview Leadership Facts Research Milestones Nobels &

  9. How a century of ammonia synthesis changed the world

    NASA Astrophysics Data System (ADS)

    Erisman, Jan Willem; Sutton, Mark A.; Galloway, James; Klimont, Zbigniew; Winiwarter, Wilfried

    2008-10-01

    On 13 October 1908, Fritz Haber filed his patent on the ``synthesis of ammonia from its elements'' for which he was later awarded the 1918 Nobel Prize in Chemistry. A hundred years on we live in a world transformed by and highly dependent upon Haber-Bosch nitrogen.

  10. Physics Meets Biology (LBNL Summer Lecture Series)

    ScienceCinema

    Chu, Steven

    2018-05-09

    Summer Lecture Series 2006: If scientists could take advantage of the awesomely complex and beautiful functioning of biology's natural molecular machines, their potential for application in many disciplines would be incalculable. Nobel Laureate and Director of the Lawrence Berkeley National Laboratory Steve Chu explores Possible solutions to global warming and its consequences.

  11. Twentieth-Century Literature in the Survey and in the Special Course.

    ERIC Educational Resources Information Center

    Adamson, Lynda G.

    1980-01-01

    Provides a semester syllabus for a course in twentieth-century world literature and suggests selections to add to a world literature survey based on works of Nobel Prize winners. Includes an annotated bibliography of background information on both the literature and the philosophies of the twentieth century. (MKM)

  12. Origin of Marshall Space Flight Center (MSFC)

    NASA Image and Video Library

    2004-04-15

    The Marshall Space Flight Center, a NASA field installation, was established at Huntsville, Alabama, in 1960. The Center was named in honor of General George C. Marshall, the Army Chief of Staff during World War II, Secretary of State, and Nobel Prize Wirner for his world-renowned Marshall Plan.

  13. Mechanism of dehydration of phenols on nobel metals using first-principles micokinetic modeling

    USDA-ARS?s Scientific Manuscript database

    Phenolic compounds constitute a sizable fraction of depolymerized biomass and are an ideal feedstock for the production of chemicals such as benzene and toluene. However, these compounds require catalytic upgrade via hydrodeoxygenation (HDO), a process whereby oxygen is removed as water by adding hy...

  14. Synthesis and photochemistry of pH-sensitive GFP chromophore analogues

    USDA-ARS?s Scientific Manuscript database

    Nobel GFP chromophore analogues containing 2-thienyl-, 5-methyl-2-furyl-, 2-pyrryl, and 6-methyl-2-pyridyl-groups were synthesized, and their fluorescence spectra were recorded across pH range of 1 to 7. The GFP chromophores prevent photoisomerizaiton in acidic media and increase their fluorescent a...

  15. Molecular plant breeding

    USDA-ARS?s Scientific Manuscript database

    “Nevertheless, the number of farmers, small as well as large, who are adopting the new seeds and new technology is increasing very rapidly, and the increase in numbers during the past three years has been phenomenal.” – Dr. Norman Borlaug This excerpt from Dr. Norman Borlaug’s Nobel Lecture at the...

  16. A Celebration of Richard Feynman

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Feynman, Richard

    In honor of the 2005 World Year of Physics, on the birthday of Nobel Prize-winning physicist Richard Feynman, BSA sponsored this celebration. Actor Norman Parker reads from Feynman's bestselling books, and Ralph Leighton and Tom Rutishauser, who played bongos with Feynman, reminisce on what it was like to drum with him.

  17. A Celebration of Richard Feynman

    ScienceCinema

    Feynman, Richard

    2018-01-05

    In honor of the 2005 World Year of Physics, on the birthday of Nobel Prize-winning physicist Richard Feynman, BSA sponsored this celebration. Actor Norman Parker reads from Feynman's bestselling books, and Ralph Leighton and Tom Rutishauser, who played bongos with Feynman, reminisce on what it was like to drum with him.

  18. The Transuranium Elements - Present Status: Nobel Lecture

    DOE R&D Accomplishments Database

    Seaborg, G. T.

    1951-12-12

    The discovery of the transuranium elements and the work done on them up to the present time are reviewed. The properties of these elements, their relationship to other elements, their place in the periodic table, and the possibility of production and identification of other transuranium elements are discussed briefly.

  19. New Languages of Possibility: Early Experiments in Education as Dissent

    ERIC Educational Resources Information Center

    Walsh, Brendan; Lalor, John

    2015-01-01

    This paper reviews the work of four early radical educators: the cultural nationalist Rabindranath Tagore (1861-1941), Asia's first Nobel Laureate; Bertrand Russell (1872-1970), Cambridge mathematician and philosopher; the Irish educationalist and insurgent Patrick Pearse (1879-1916) and Leonard Elmhirst (1893-1975), co-founder of Dartington Hall…

  20. Gender, Self-Concept, and Reading Disabilities.

    ERIC Educational Resources Information Center

    Fink, Rosalie P.

    2000-01-01

    A study of highly successful men and women with reading disabilities used a developmental approach to investigate how, and under what conditions, males and females with reading disabilities develop high literacy levels and resilient self-concepts. The 60 participants in the study included a Nobel laureate, a member of the National Academy of…

  1. Artificial recharge through a well in fissured carbonate rock, west St. Paul, Minnesota

    USGS Publications Warehouse

    Reeder, Harold O.; Wood, Warren W.; Ehrlich, G.G.; Sun, Ren Jen

    1976-01-01

    The injection test demonstrated that it is hydrologically feasible to recharge the Prairie du Chien Group and the Jordan Sandstone artificially through wells completed in the Prairie du Chien Group. The fissures in the Prairie du Chien Group act as conduits through which water spreads. The water passes into the Jordan Sandstone from the Prairie du Chien over a larger area than it would if it were injected directly into the Jordan.

  2. Prevalence of duodenal ulcer-promoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population.

    PubMed

    Arachchi, H S Jayasinghe; Kalra, Vijay; Lal, Banwari; Bhatia, Vikram; Baba, C S; Chakravarthy, S; Rohatgi, S; Sarma, Priyangshu M; Mishra, V; Das, Bimal; Ahuja, Vineet

    2007-12-01

    The duodenal ulcer (DU)-promoting gene (dupA) of Helicobacter pylori has been identified as a novel virulent marker associated with an increased risk for DU. The presence or absence of dupA gene of H. pylori present in patients with DU and functional dyspepsia in North Indian population was studied by polymerase chain reaction (PCR) and hybridization analysis. One hundred and sixty-six patients (96 DU and 70 functional dyspepsia) were included in this study. In addition, sequence diversity of dupA gene of H. pylori found in these patients was analyzed by sequencing the PCR products jhp0917 and jhp0918 on both strands with appropriate primers. PCR and hybridization analyses indicated that dupA gene was present in 37.5% (36/96) of H. pylori strains isolated from DU patients and 22.86% (16/70) of functional dyspepsia patients (p < or = .05). Of these, 35 patients with DU (97.2%) and 14 patients with functional dyspepsia (81.25%) were infected by H. pylori positive for cagA genotype. Furthermore, the presence of dupA was significantly associated with the cagA-positive genotype (p < or = .02). Results of our study have shown that significant association of dupA gene with DU in this population. The dupA gene can be considered as a novel virulent marker for DU in this population.

  3. Hazardous Waste Cleanup: DuPont Imaging Department in Parlin, New Jersey

    EPA Pesticide Factsheets

    DuPont has owned and operated a chemical manufacturing plant on Cheesequake Road in Parlin, New Jersey, since 1904. DuPont manufactured a variety of products at the plant including, photographic films, automotive paints, pigments, adhesives, thinners,

  4. Can preoperative detrusor underactivity influence surgical outcomes of 120 W HPS vaporization of the prostate (PVP) or holmium laser enucleation of the prostate (HoLEP)? A serial 3-year follow-up study.

    PubMed

    Cho, Min Chul; Park, Juhyun; Kim, Jung Kwon; Cho, Sung Yong; Jeong, Hyeon; Oh, Seung-June; Paick, Jae-Seung; Son, Hwancheol

    2018-01-01

    To determine the influence of preoperative detrusor underactivity (DU) on serial long-term outcomes of HPS/PVP or HoLEP for LUTS/BPH, and to compare the influence between the two surgeries. A total of 382 men, who underwent 120W-HPS/PVP or HoLEP for LUTS/BPH and for whom 36-month follow-up data were available, were classified into four groups: HPS with DU (n = 145), HPS without DU (n = 44), HoLEP with DU (n = 105), and HoLEP without DU (n = 88). DU was defined as bladder contractility index of <100. Surgical outcomes were assessed at postoperative 6, 12, 24, and 36 months using IPSS, uroflowmetry, and serum PSA. All four groups maintained improvements in voiding symptom score (VSS), storage symptom score, total-IPSS, QOL index, maximum flow rate (Qmax), post-void residual urine volume (PVR), and bladder voiding efficiency (BVE) compared with baseline up to 3 years postoperatively. There were no significant differences in improvements of postoperative IPSS parameters including QOL index between men with and without DU throughout the follow-up period after HPS or HoLEP. In men with DU, there were no significant differences in improvements of postoperative QOL index, Qmax, PVR, or BVE between HPS and HoLEP groups throughout the follow-up period, except for VSS and total IPSS. Serum PSA reductions after HoLEP were greater than after PVP. Improvements in LUTS, Qmax, and BVE can maintain up to 3 years after HPS or HoLEP for LUTS/BPH, irrespective of the presence or absence of preoperative DU. Although HoLEP may provide more durable improvement of VS in men with DU than HPS, there seems to be no difference in improvement of QOL or Qmax or BVE between HPS and HoLEP. © 2017 Wiley Periodicals, Inc.

  5. Depleted uranium exposure and health effects in Gulf War veterans

    PubMed Central

    Squibb, Katherine S; McDiarmid, Melissa A

    2006-01-01

    Health effects stemming from depleted uranium (DU) exposure in a cohort of Gulf War veterans who were in or on US Army vehicles hit by friendly fire involving DU munitions are being carefully monitored through the Baltimore Veterans Affairs (VA) DU Follow-Up Program initiated in 1993. DU exposure in this cohort has been directly measured using inductively coupled plasma-mass spectrometer (ICP-MS) isotopic analysis for DU in urine specimens. Soldiers with embedded DU fragments continue to excrete elevated concentrations of U in their urine, documenting ongoing systemic exposure to U released from their fragments. Biennial surveillance visits provide a detailed health assessment that includes basic clinical measures and surveillance for early changes in kidney function, an expected target organ for U. Tests also include measurements of genotoxicity and neuroendocrine, neurocognitive and reproductive function. With the exception of the elevated urine U excretion, no clinically significant expected U-related health effects have been identified to date. Subtle changes in renal function and genotoxicity markers in veterans with urine U concentrations greater than 0.1 μg−1 creatinine, however, indicate the need for continued surveillance of these DU-exposed veterans. PMID:16687268

  6. CFD Simulations of a Ferry in Head Seas

    DTIC Science & Technology

    2011-03-01

    la durée de vie en fatigue globale du navire. Il est important, pour la conception, l’exploitation et la gestion du cycle de ...vibration de frottement qui exerce une contrainte sur la structure de coque primaire et qui a un effet défavorable sur la durée de vie en fatigue globale du ...laquelle ne peut simuler directement la physique du tossage. Le présent rapport contient les résultats d’une étude faisant

  7. Development of Measures of Effectiveness and Performance from Cognitive Work Analysis Products

    DTIC Science & Technology

    2012-02-01

    la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2012 DRDC Atlantic CR 2011...le nouveau concept du système. Ce rapport vise à déterminer si les résultats du travail de conception peuvent aider à élaborer des mesures de ...l’information (IIDS). Le contrat actuel comportait deux objectifs : élaborer des mesures de l’efficacité (MOE) et du rendement (MOP) pour

  8. V2010 Security Planning and Operations: A Social Network Study of Key Information Sharing Relationships

    DTIC Science & Technology

    2011-05-01

    la scurit. Je vous remercie de votre temps et de votre contribution. Susan G. McIntyre Knowledge Management/ Gestion du savoir...National Defence, 2011 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 DRDC CSS TR 2011...avantages du renforcement de la communication horizontale au sein du gouvernement fédéral, surtout en présence d’organismes de

  9. Depleted uranium: properties, military use and health risks.

    PubMed

    Fairlie, Ian

    2009-01-01

    This article describes uranium and depleted uranium (DU), their similar isotopic compositions, how DU arises, its use in munitions and armour-proofing, and its pathways for human exposures. Particular attention is paid to the evidence of DU's health effects from cell and animal experiments and from epidemiology studies. It is concluded that a precautionary approach should be adopted to DU and that there should be a moratorium on its use by military forces. International efforts to this end are described.

  10. In vivo detection of hyperoxia-induced pulmonary endothelial cell death using (99m)Tc-duramycin.

    PubMed

    Audi, Said H; Jacobs, Elizabeth R; Zhao, Ming; Roerig, David L; Haworth, Steven T; Clough, Anne V

    2015-01-01

    (99m)Tc-duramycin, DU, is a SPECT biomarker of tissue injury identifying cell death. The objective of this study is to investigate the potential of DU imaging to quantify capillary endothelial cell death in rat lung injury resulting from hyperoxia exposure as a model of acute lung injury. Rats were exposed to room air (normoxic) or >98% O2 for 48 or 60 hours. DU was injected i.v. in anesthetized rats, scintigraphy images were acquired at steady-state, and lung DU uptake was quantified from the images. Post-mortem, the lungs were removed for histological studies. Sequential lung sections were immunostained for caspase activation and endothelial and epithelial cells. Lung DU uptake increased significantly (p<0.001) by 39% and 146% in 48-hr and 60-hr exposed rats, respectively, compared to normoxic rats. There was strong correlation (r(2)=0.82, p=0.005) between lung DU uptake and the number of cleaved caspase 3 (CC3) positive cells, and endothelial cells accounted for more than 50% of CC3 positive cells in the hyperoxic lungs. Histology revealed preserved lung morphology through 48 hours. By 60 hours there was evidence of edema, and modest neutrophilic infiltrate. Rat lung DU uptake in vivo increased after just 48 hours of >98% O2 exposure, prior to the onset of any substantial evidence of lung injury. These results suggest that apoptotic endothelial cells are the primary contributors to the enhanced DU lung uptake, and support the utility of DU imaging for detecting early endothelial cell death in vivo. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. W. E. B. Du Bois at the center: from science, civil rights movement, to Black Lives Matter.

    PubMed

    Morris, Aldon

    2017-03-01

    I am honoured to present the 2016 British Journal of Sociology Annual Lecture at the London School of Economics. My lecture is based on ideas derived from my new book, The Scholar Denied: W.E.B. Du Bois and the Birth of Modern Sociology. In this essay I make three arguments. First, W.E.B. Du Bois and his Atlanta School of Sociology pioneered scientific sociology in the United States. Second, Du Bois pioneered a public sociology that creatively combined sociology and activism. Finally, Du Bois pioneered a politically engaged social science relevant for contemporary political struggles including the contemporary Black Lives Matter movement. © London School of Economics and Political Science 2017.

  12. The du Bois sign.

    PubMed

    Voelpel, James H; Muehlberger, Thomas

    2011-03-01

    According to the current literature, the term "du Bois sign" characterizes the condition of a shortened fifth finger as a symptom of congenital syphilis, Down syndrome, dyscrania, and encephalic malformation. Modern medical dictionaries and text books attribute the eponym to the French gynecologist Paul Dubois (1795-1871). Yet, a literature analysis revealed incorrect references to the person and unclear definitions of the term. Our findings showed that the origin of the term is based on observations made by the Swiss dermatologist Charles du Bois (1874-1947) in connection with congenital syphilis. In addition, a further eponymical fifth finger sign is closely associated with the du Bois sign. In conclusion, the du Bois sign has only limited diagnostic value and is frequently occurring in the normal healthy population.

  13. Révision de la sous-famille des Metaracoelophryinae de Puytorac 1972 (Oligohymenophora : Hoplytophryida : Hoplytophryidae), ciliés astomes du tube digestif d’oligochètes terricoles d’Afrique : description de cinq espèces nouvelles

    PubMed Central

    Fokam, Z.; Ngassam, P.; Nana, P.A.; Bricheux, G.; Bouchard, P.; Sime Ngando, T.

    2012-01-01

    Cinq nouvelles espèces de ciliés astomes, présentes dans le tube digestif de vers oligochètes du genre Alma du Cameroun, ont été décrites. Les techniques utilisées sont : l’observation vitale, la coloration au DAPI, la microscopie électronique à balayage et les imprégnations argentiques selon Fernandez Galiano, 1966. Ce travail confirme la présence des genres Paracoelophrya et Dicoelophrya dans le tube digestif des oligochètes du genre Alma du Gabon et du Cameroun ; il permet de faire une synthèse récapitulative de la sous-famille des Metaracoelophryinae. De plus, est confirmée l’homogénéité de ce groupe, et est reposée la question de la parenté phylogénétique des Hoplitophryida. PMID:22314239

  14. An investigation of duck circovirus and co-infection in Cherry Valley ducks in Shandong Province, China.

    PubMed

    Zhang, Xingxiao; Jiang, Shijin; Wu, Jiaqiang; Zhao, Qin; Sun, Yani; Kong, Yibo; Li, Xiaoxia; Yao, Meiling; Chai, Tongjie

    2009-01-13

    The co-infection of duck circovirus (DuCV) with Riemerella anatipestifer (RA) or/and Escherichia coli (E. coli) or/and duck hepatitis virus I (DHV-I) in Cherry Valley ducks in China's Shandong Province was investigated by using polymerase-chain-reaction (PCR)-based methods. For this study, 742 ducks sampled at random from 70 duck farms during 2006-2007 were examined using PCR and dot-blot hybridisation (DBH) tests. Overall the DuCV infection rate was 33.29%. Compared with those at 2 weeks of age, the ducks at 3-4 weeks of age were more susceptible to DuCV infection. Compared with the DuCV-negative ones, the DuCV-positive ducks had a higher rate of infection by DHV-I (25.5% vs. 7.475%), RA (23.48% vs. 8.28%) and E. coli (16.19% vs. 4.85%). This investigation shows that DuCV infection is common in Cherry Valley ducks on some farms in Shandong Province.

  15. Etude thermo-hydraulique de l'ecoulement du moderateur dans le reacteur CANDU-6

    NASA Astrophysics Data System (ADS)

    Mehdi Zadeh, Foad

    Etant donne la taille (6,0 m x 7,6 m) ainsi que le domaine multiplement connexe qui caracterisent la cuve des reacteurs CANDU-6 (380 canaux dans la cuve), la physique qui gouverne le comportement du fluide moderateur est encore mal connue de nos jours. L'echantillonnage de donnees dans un reacteur en fonction necessite d'apporter des changements a la configuration de la cuve du reacteur afin d'y inserer des sondes. De plus, la presence d'une zone intense de radiations empeche l'utilisation des capteurs courants d'echantillonnage. En consequence, l'ecoulement du moderateur doit necessairement etre etudie a l'aide d'un modele experimental ou d'un modele numerique. Pour ce qui est du modele experimental, la fabrication et la mise en fonction de telles installations coutent tres cher. De plus, les parametres de la mise a l'echelle du systeme pour fabriquer un modele experimental a l'echelle reduite sont en contradiction. En consequence, la modelisation numerique reste une alternative importante. Actuellement, l'industrie nucleaire utilise une approche numerique, dite de milieu poreux, qui approxime le domaine par un milieu continu ou le reseau des tubes est remplace par des resistances hydrauliques distribuees. Ce modele est capable de decrire les phenomenes macroscopiques de l'ecoulement, mais ne tient pas compte des effets locaux ayant un impact sur l'ecoulement global, tel que les distributions de temperatures et de vitesses a proximite des tubes ainsi que des instabilites hydrodynamiques. Dans le contexte de la surete nucleaire, on s'interesse aux effets locaux autour des tubes de calandre. En effet, des simulations faites par cette approche predisent que l'ecoulement peut prendre plusieurs configurations hydrodynamiques dont, pour certaines, l'ecoulement montre un comportement asymetrique au sein de la cuve. Ceci peut provoquer une ebullition du moderateur sur la paroi des canaux. Dans de telles conditions, le coefficient de reactivite peut varier de maniere importante, se traduisant par l'accroissement de la puissance du reacteur. Ceci peut avoir des consequences majeures pour la surete nucleaire. Une modelisation CFD (Computational Fluid Dynamics) detaillee tenant compte des effets locaux s'avere donc necessaire. Le but de ce travail de recherche est de modeliser le comportement complexe de l'ecoulement du moderateur au sein de la cuve d'un reacteur nucleaire CANDU-6, notamment a proximite des tubes de calandre. Ces simulations servent a identifier les configurations possibles de l'ecoulement dans la calandre. Cette etude consiste ainsi a formuler des bases theoriques a l'origine des instabilites macroscopiques du moderateur, c.-a-d. des mouvements asymetriques qui peuvent provoquer l'ebullition du moderateur. Le defi du projet est de determiner l'impact de ces configurations de l'ecoulement sur la reactivite du reacteur CANDU-6.

  16. Products of in Situ Corrosion of Depleted Uranium Ammunition in Bosnia and Herzegovina Soils.

    PubMed

    Wang, Yuheng; von Gunten, Konstantin; Bartova, Barbora; Meisser, Nicolas; Astner, Markus; Burger, Mario; Bernier-Latmani, Rizlan

    2016-11-15

    Hundreds of tons of depleted uranium (DU) ammunition were used in previous armed conflicts in Iraq, Bosnia and Herzegovina, and Serbia/Kosovo. The majority (>90%) of DU penetrators miss their target and, if left in the environment, corrode in these postconflict zones. Thus, the best way to understand the fate of bulk DU material in the environment is to characterize the corrosion products of intact DU penetrators under field conditions for extended periods of time. However, such studies are scarce. To fill this knowledge gap, we characterized corrosion products formed from two intact DU penetrators that remained in soils in Bosnia and Herzegovina for over seven years. We used a combination of X-ray powder diffraction, electron microscopy, and X-ray absorption spectroscopy. The results show that metaschoepite (UO 3 (H 2 O) 2 ) was a main component of the two DU corrosion products. Moreover, studtite ((UO 2 )O 2 (H 2 O) 2 ·2(H 2 O)) and becquerelite (Ca(UO 2 ) 6 O 4 (OH) 6 ·8(H 2 O)) were also identified in the corrosion products. Their formation through transformation of metaschoepite was a result of the geochemical conditions under which the penetrators corroded. Moreover, we propose that the transformation of metaschoepite to becquerelite or studtite in the DU corrosion products would decrease the potential for mobilization of U from corroded DU penetrators exposed to similar environments in postconflict areas.

  17. Applications of Capstone Depleted Uranium Aerosol Risk Data to Military Combat Risk Management

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Daxon, Eric G.; Parkhurst, MaryAnn; Melanson, Mark A.

    2009-03-01

    Risks to personnel engaged in military operations include not only the threat of enemy firepower but also risks from exposure to other hazards such as radiation. Combatant commanders of the U. S. Army carefully weigh risks of casualties before implementing battlefield actions using an established paradigm that take these risks into consideration. As a result of the inclusion of depleted uranium (DU) anti-armor ammunition in the conventional (non-nuclear) weapons arsenal, the potential for exposure to DU aerosols and its associated chemical and radiological effects becomes an element of the commanders’ risk assessment. The Capstone DU Aerosol Study measured the rangemore » of likely DU oxide aerosol concentrations created inside a combat vehicle perforated with a DU munition, and the Capstone Human Health Risk Assessment (HHRA) estimated the associated doses and calculated risks. This paper focuses on the development of a scientific approach to adapt the risks from DU’s non uniform dose distribution within the body using the current U.S. Department of Defense (DoD) radiation risk management approach. The approach developed equates the Radiation Exposure Status (RES) categories to the estimated radiological risks of DU and makes use of the Capstone-developed Renal Effects Group (REG) as a measure of chemical risk from DU intake. Recommendations are provided for modifying Army guidance and policy in order to better encompass the potential risks from DU aerosol inhalation during military operations.« less

  18. Are dentists enough aware of infectious risk associated with dental unit waterlines ?

    PubMed

    Robert, Amélie; Bousseau, Anne; Costa, Damien; Barbot, Vanessa; Imbert, Christine

    2013-07-10

    Environmental conditions in DU encourage biofilm development. This biofilm may represent a risk for patients and dental staff exposed to water and aerosols generated during dental cares, particularly for immunocompromised persons. A survey was conducted on the 175 dental surgeons of the department of Vienne (France) to investigate the motivations of dental practitioners to renew their DU, their awareness levels with respect to infectious risks related to water circulating within DU, and methods used for the maintenance of DU waterlines. These dentists were only partially aware of the need for maintaining DU waterlines. For this maintaining, chemical treatments and purges of pipes were carried out by 88% and 91.5% of dentists respectively ; chemical treatments were usually on a continous mode and dentists seemed to have complete confidence in their DU supplier regarding the choice and the use of chemical treatments. Flushes were performed only once per day in most cases (63%). This survey also highlighted that dentists were not enough aware of water related infectous risk, even though 68% estimated that the development of a biofilm within DU waterlines was an actual risk. Finally, very positively, dentists strongly indicated their wish to be more informed regarding all these risks. Although these results are based on a relatively small sample, corresponding to dentists of a French department, they clearly suggest that awareness of dental surgeons is still insufficient and must be performed to permit an effective prevention of infectious risk related to DU waterlines.

  19. Sources of Financial Support for Research Prize Winners.

    ERIC Educational Resources Information Center

    National Science Foundation, Washington, DC.

    The principal objective of this study was to determine the organizational sources of support for the scientists and engineers who have received the Nobel and other major scientific prizes. A secondary objective was to determine what role the National Science Foundation (NSF) may have played in the recipients' research careers. The results of the…

  20. Collection Development: Celebrating Chemistry, February 1, 2011

    ERIC Educational Resources Information Center

    Hamm, Susannah

    2011-01-01

    A hundred years after Marie Curie received her Nobel Prize in Chemistry, this arm of science is pointing the way to a more sustainable future. Growing movements like green chemistry, which strives to create alternative and new chemical reactions that produce no harmful waste products, and molecular engineering hold great potential for industry,…

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