Properties, use and health effects of depleted uranium (DU): a general overview.

PubMed

Bleise, A; Danesi, P R; Burkart, W

2003-01-01

Depleted uranium (DU), a waste product of uranium enrichment, has several civilian and military applications. It was used as armor-piercing ammunition in international military conflicts and was claimed to contribute to health problems, known as the Gulf War Syndrome and recently as the Balkan Syndrome. This led to renewed efforts to assess the environmental consequences and the health impact of the use of DU. The radiological and chemical properties of DU can be compared to those of natural uranium, which is ubiquitously present in soil at a typical concentration of 3 mg/kg. Natural uranium has the same chemotoxicity, but its radiotoxicity is 60% higher. Due to the low specific radioactivity and the dominance of alpha-radiation no acute risk is attributed to external exposure to DU. The major risk is DU dust, generated when DU ammunition hits hard targets. Depending on aerosol speciation, inhalation may lead to a protracted exposure of the lung and other organs. After deposition on the ground, resuspension can take place if the DU containing particle size is sufficiently small. However, transfer to drinking water or locally produced food has little potential to lead to significant exposures to DU. Since poor solubility of uranium compounds and lack of information on speciation precludes the use of radioecological models for exposure assessment, biomonitoring has to be used for assessing exposed persons. Urine, feces, hair and nails record recent exposures to DU. With the exception of crews of military vehicles having been hit by DU penetrators, no body burdens above the range of values for natural uranium have been found. Therefore, observable health effects are not expected and residual cancer risk estimates have to be based on theoretical considerations. They appear to be very minor for all post-conflict situations, i.e. a fraction of those expected from natural radiation.

Fiches pratiques: Systeme temporel du passe; Le Village, dossier langue (extraits); L'Inspecteur mene l'enquete; La ZUP (Practical Ideas: Temporal System of the Past Tense; The Village, Language File; The Inspector Leads the Investigation; The Urban Priority Zone).

ERIC Educational Resources Information Center

de Meyer, Bernard; And Others

1993-01-01

Four instructional ideas for use in the French second-language classroom are described, including an exercise in the temporal aspect of French past tenses; part of a series on simulating a French village community; a verb tense drill set in the context of a murder mystery; and an exercise in current French street slang. (MSE)

Systemes Fermioniques a Basse Dimension D'espace: Supraconductivite, Effet Hall Quantique et Statistique Fractionnaire

NASA Astrophysics Data System (ADS)

Sakhi, Said

Cette these est constituee de trois sujets de recherche distincts. Les deux premiers articles traitent du phenomene de supraconductivite dans un modele bidimensionnel, dans le troisieme article on etudie l'action effective d'un systeme electronique soumis a l'effet d'un champ magnetique (systeme de Hall) et le dernier article examine la quantification d'un systeme de particules identiques en deux dimensions d'espace et la possibilite des anyons. Le modele qu'on analyse dans les deux premiers articles est un systeme fermionique dont les particules chargees et de masse nulle interagissent entre elles avcc un couplage attractif et fort. L'analyse de l'action effective decrivant la physique a basse energie nous permet d'examiner la structure de l'espace de phase. A temperature nulle, le parametre d'ordre du systeme prend une valeur moyenne non nulle. Consequemment, la symetrie continue U(1) du modele est spontanement brisee et il en resulte l'apparition d'un mode de Goldstone. En presence d'un champ electromagnetique externe, ce mode disparait et le champ de jauge acquiert une masse donc l'effet Meissner caracteristique d'un supraconducteur. Bien que le modele ne soit pas renormalisable dans le sens perturbatif, on montre qu'il l'est dans le cadre du developpement en 1/N ou N est le nombre d'especes fermioniques. En outre, on montre que l'inclusion des effets thermiques change radicalement le mecanisme de supraconductivite. En effet, on montre que la brisure spontanee de la symetrie U(1) n'est plus possible a temperature finie a cause de tres severes divergences infrarouges. Par contre, la dynamique des tourbillons (vortex) existant dans le plan devient essentielle. On montre que le phenomene de supraconductivite resulte du confinement de ces objets topologiques et que la temperature critique s'identifie a celle de Kosterlitz -Thouless. Ce mecanisme de supraconductivite presente l'avantage d'aboutir a un rapport gap a la temperature critique plus eleve que celui du modele de BCS et la non violation de la symetrie par renversement du temps et de l'espace contrairement au modele anyonique. Dans le troisieme article, on a developpe une methode systematique pour calculer les determinants fermioniques en presence d'un champ magnetique perpendiculaire au plan de confinement des particules. Aussi bien les effets thermiques que ceux dus aux impuretes sont pris en consideration dans cette methode. La technique est illustree dans le cas du systeme de Hall quantique. Finalement, dans le dernier article, on discute la quantification d'un systeme de particules identiques dans le plan. Apres avoir correctement defini l'espace de phase classique du systeme, l'analyse fait ressortir deux parametres fondamentaux denotes par theta et alpha. Le premier parametre theta est associe a l'intensite du flux magnetique localise au vertex du cone et definit la statistique des particules. Pour des valeurs arbitraires de theta on parle d'anyons. L'autre parametre alpha est associe a l'extension auto-adjointe de l'hamiltonien et ressort de l'unitarite de la theorie. On montre par un exemple explicite que alpha peut etre vu comme le vestige d'une interaction a tres courte distance (haute energie) entre les particules du systeme. Finalement, on montre que le groupe de symetrie du systeme avec extension auto -adjointe n'est plus SO(2,1) car le generateur de dilatation de ce groupe n'est plus compatible avec un parametre alpha arbitraire. (Abstract shortened by UMI.).

Cirque du Monde as a health intervention: perceptions of medical students and social circus experts.

PubMed

Fournier, Cynthia; Drouin, Mélodie-Anne; Marcoux, Jérémie; Garel, Patricia; Bochud, Emmanuel; Théberge, Julie; Aubertin, Patrice; Favreau, Gil; Fleet, Richard

2014-11-01

To present Cirque du Soleil's social circus program, Cirque du Monde, to explore its potential as a primary health care tool for family physicians. A review of the literature in PubMed, the Cochrane Library, PsycINFO, LaPresse, Eureka, Google Scholar, and Érudit using the key words circus, social circus, Cirque du Monde, and Cirque du Soleil; a Montreal-based initiative, Espace Transition, modeled on Cirque du Monde; and personal communication with Cirque du Soleil's Social Circus Training Advisor. The first 50 articles or websites identified for each key word in each of the databases were examined on the basis of their titles and abstracts in the case of articles, and on the basis of their titles and page content in the case of websites. Articles and websites that explored an aspect of social circuses or that described an intervention that involved circuses were then retained for analysis. Because all literature on social circuses was searched, no criterion for year of publication was used. No articles on the social circus as a health intervention were found. One study on the use of the circus as an intervention in schools was identified. It demonstrated an increase in self-esteem in the children who took part. One study on the use of the circus in a First Nations community was found; it contained nonspecific, qualitative findings. The other articles identified were merely descriptions of social circuses. One website was identified on the use of the social circus to help youth who had been treated in a hospital setting for major psychiatric disorders to re-enter the community. The team in the pediatric psychiatry department at Centre Hospitalier Universitaire Sainte-Justine, the children's hospital in Montreal, Que, was contacted; they were leading this project, called Espace Transition. The unpublished preliminary findings of its pilot project demonstrate substantial improvements in overall patient functioning. According to Cirque du Soleil, there are several projects under way around the world researching the therapeutic value of social circuses. Cirque du Monde is able to reach a marginalized population that is otherwise difficult for the health system to reach. This program has therapeutic potential because of its target population, its promotion of healthy habits, and the support that it offers through the group and its workers. Cirque du Soleil is investing heavily in this project. The lack of literature yielding robust data on the social circus is therefore an important issue. Copyright© the College of Family Physicians of Canada.

Cirque du Monde as a health intervention

PubMed Central

Fournier, Cynthia; Drouin, Mélodie-Anne; Marcoux, Jérémie; Garel, Patricia; Bochud, Emmanuel; Théberge, Julie; Aubertin, Patrice; Favreau, Gil; Fleet, Richard

2014-01-01

Abstract Objective To present Cirque du Soleil’s social circus program, Cirque du Monde, to explore its potential as a primary health care tool for family physicians. Data sources A review of the literature in PubMed, the Cochrane Library, PsycINFO, LaPresse, Eureka, Google Scholar, and Érudit using the key words circus, social circus, Cirque du Monde, and Cirque du Soleil; a Montreal-based initiative, Espace Transition, modeled on Cirque du Monde; and personal communication with Cirque du Soleil’s Social Circus Training Advisor. Study selection The first 50 articles or websites identified for each key word in each of the databases were examined on the basis of their titles and abstracts in the case of articles, and on the basis of their titles and page content in the case of websites. Articles and websites that explored an aspect of social circuses or that described an intervention that involved circuses were then retained for analysis. Because all literature on social circuses was searched, no criterion for year of publication was used. Synthesis No articles on the social circus as a health intervention were found. One study on the use of the circus as an intervention in schools was identified. It demonstrated an increase in self-esteem in the children who took part. One study on the use of the circus in a First Nations community was found; it contained nonspecific, qualitative findings. The other articles identified were merely descriptions of social circuses. One website was identified on the use of the social circus to help youth who had been treated in a hospital setting for major psychiatric disorders to re-enter the community. The team in the pediatric psychiatry department at Centre Hospitalier Universitaire Sainte-Justine, the children’s hospital in Montreal, Que, was contacted; they were leading this project, called Espace Transition. The unpublished preliminary findings of its pilot project demonstrate substantial improvements in overall patient functioning. According to Cirque du Soleil, there are several projects under way around the world researching the therapeutic value of social circuses. Conclusion Cirque du Monde is able to reach a marginalized population that is otherwise difficult for the health system to reach. This program has therapeutic potential because of its target population, its promotion of healthy habits, and the support that it offers through the group and its workers. Cirque du Soleil is investing heavily in this project. The lack of literature yielding robust data on the social circus is therefore an important issue. PMID:25392449

A comparison of linear respiratory system models based on parameter estimates from PRN forced oscillation data.

PubMed

Diong, B; Grainger, J; Goldman, M; Nazeran, H

2009-01-01

The forced oscillation technique offers some advantages over spirometry for assessing pulmonary function. It requires only passive patient cooperation; it also provides data in a form, frequency-dependent impedance, which is very amenable to engineering analysis. In particular, the data can be used to obtain parameter estimates for electric circuit-based models of the respiratory system, which can in turn aid the detection and diagnosis of various diseases/pathologies. In this study, we compare the least-squares error performance of the RIC, extended RIC, augmented RIC, augmented RIC+I(p), DuBois, Nagels and Mead models in fitting 3 sets of impedance data. These data were obtained by pseudorandom noise forced oscillation of healthy subjects, mild asthmatics and more severe asthmatics. We found that the aRIC+I(p) and DuBois models yielded the lowest fitting errors (for the healthy subjects group and the 2 asthmatic patient groups, respectively) without also producing unphysiologically large component estimates.

Cellular Automata

NASA Astrophysics Data System (ADS)

Gutowitz, Howard

1991-08-01

Cellular automata, dynamic systems in which space and time are discrete, are yielding interesting applications in both the physical and natural sciences. The thirty four contributions in this book cover many aspects of contemporary studies on cellular automata and include reviews, research reports, and guides to recent literature and available software. Chapters cover mathematical analysis, the structure of the space of cellular automata, learning rules with specified properties: cellular automata in biology, physics, chemistry, and computation theory; and generalizations of cellular automata in neural nets, Boolean nets, and coupled map lattices. Current work on cellular automata may be viewed as revolving around two central and closely related problems: the forward problem and the inverse problem. The forward problem concerns the description of properties of given cellular automata. Properties considered include reversibility, invariants, criticality, fractal dimension, and computational power. The role of cellular automata in computation theory is seen as a particularly exciting venue for exploring parallel computers as theoretical and practical tools in mathematical physics. The inverse problem, an area of study gaining prominence particularly in the natural sciences, involves designing rules that possess specified properties or perform specified task. A long-term goal is to develop a set of techniques that can find a rule or set of rules that can reproduce quantitative observations of a physical system. Studies of the inverse problem take up the organization and structure of the set of automata, in particular the parameterization of the space of cellular automata. Optimization and learning techniques, like the genetic algorithm and adaptive stochastic cellular automata are applied to find cellular automaton rules that model such physical phenomena as crystal growth or perform such adaptive-learning tasks as balancing an inverted pole. Howard Gutowitz is Collaborateur in the Service de Physique du Solide et Résonance Magnetique, Commissariat a I'Energie Atomique, Saclay, France.

Ground-based total ozone column measurements and their diurnal variability

NASA Astrophysics Data System (ADS)

Silva, Abel A.

2013-07-01

Brewer spectrophotometers were set up in three tropical sites of South America (in the Bolivian Altiplano and seashore and biomass burning areas of Brazil) to measure the total ozone column (TOC). Only TOC measurements with uncertainties ≤1% (1σ) were considered. Typically, the standard deviation for the diurnal sets of measurements was predominantly ≤1% for two of these sites. The average variability in TOC ranged from 6.3 Dobson units (DU) to 16.8 DU, and the largest variability reached 54.3 DU. Comparisons between ground-based and satellite (Total Ozone Mapping Spectrometer (TOMS)) data showed good agreement with coefficients of determination ≤0.83. However, the quality of the ground-based measurements was affected by the weather condition, especially for one of the sites. Visual observation of the sky from the ground during the measurements with one of the Brewers added to the satellite data of reflectivity and aerosol index supports that statement.

Digital ulcers in systemic sclerosis: role of flow-mediated dilatation and capillaroscopy as risk assessment tools.

PubMed

Silva, Ivone; Loureiro, Tiago; Teixeira, Andreia; Almeida, Isabel; Mansilha, Armando; Vasconcelos, Carlos; Almeida, Rui

2015-01-01

The aim of this study was to evaluate macrovascular endothelial dysfunction and microvascular damage as clinical markers of peripheral microangiopathy in patients with Raynaud's phenomenon (RP). Seventy-seven secondary RP with systemic sclerosis, 32 primary RP and 34 healthy controls were included in our study. Secondary RP patients were divided into two subgroups: 39 with digital ulcers (DU) and 38 without digital ulcers (non-DU). Patients with DU had significantly lower flow-mediated dilatation values (5.34 ± 7.49%) compared to non-DU patients (16.21 ± 11.31%), primary RP (17.96 ± 12.78%) and controls (20.17 ± 8.86%), p<0.001, favouring macrovascular endothelium dysfunction. Regarding microvascular damage, the DU group had a predominately capillaroscopic late pattern (71.1%) whereas non-DU patients had an active pattern (56.4%). The microangiopathy evolution score was significantly higher in the DU group compared to the non-DU group (4.79 ± 1.82 vs. 1.79 ± 1.56, p<0.001). Flow-mediated dilation was significantly lower in late pattern (6.13 ± 7.09%) compared to active (12.58 ± 10.66%) and early patterns (17.72 ± 14.90%), p = 0.016 and p = 0.044 respectively. Low flow-mediated dilatation and microvascular damage in capillaroscopy are early clinical markers of DU risk in RP patients.

Identification des parametres du moteur de l'avion Cessna Citation X pour la phase de croisiere a partir des tests en vol et a base des reseaux de neurones =

NASA Astrophysics Data System (ADS)

Zaag, Mahdi

La disponibilite des modeles precis des avions est parmi les elements cles permettant d'assurer leurs ameliorations. Ces modeles servent a ameliorer les commandes de vol et de concevoir de nouveaux systemes aerodynamiques pour la conception des ailes deformables des avions. Ce projet consiste a concevoir un systeme d'identification de certains parametres du modele du moteur de l'avion d'affaires americain Cessna Citation X pour la phase de croisiere a partir des essais en vol. Ces essais ont ete effectues sur le simulateur de vol concu et fabrique par CAE Inc. qui possede le niveau D de la dynamique de vol. En effet, le niveau D est le plus haut niveau de precision donne par l'autorite federale de reglementation FAA de l'aviation civile aux Etats-Unis. Une methodologie basee sur les reseaux de neurones optimises a l'aide d'un algorithme intitule le "grand deluge etendu" est utilisee dans la conception de ce systeme d'identification. Plusieurs tests de vol pour differentes altitudes et differents nombres de Mach ont ete realises afin de s'en servir comme bases de donnees pour l'apprentissage des reseaux de neurones. La validation de ce modele a ete realisee a l'aide des donnees du simulateur. Malgre la nonlinearite et la complexite du systeme, les parametres du moteur ont ete tres bien predits pour une enveloppe de vol determinee. Ce modele estime pourrait etre utilise pour des analyses de fonctionnement du moteur et pourrait assurer le controle de l'avion pendant cette phase de croisiere. L'identification des parametres du moteur pourrait etre realisee aussi pour les autres phases de montee et de descente afin d'obtenir son modele complet pour toute l'enveloppe du vol de l'avion Cessna Citation X (montee, croisiere, descente). Cette methode employee dans ce travail pourrait aussi etre efficace pour realiser un modele pour l'identification des coefficients aerodynamiques du meme avion a partir toujours des essais en vol. None None None

Ecological risk assessment of depleted uranium in the environment at Aberdeen Proving Ground

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clements, W.H.; Kennedy, P.L.; Myers, O.B.

1993-01-01

A preliminary ecological risk assessment was conducted to evaluate the effects of depleted uranium (DU) in the Aberdeen Proving Ground (APG) ecosystem and its potential for human health effects. An ecological risk assessment of DU should include the processes of hazard identification, dose-response assessment, exposure assessment, and risk characterization. Ecological risk assessments also should explicitly examine risks incurred by nonhuman as well as human populations, because risk assessments based only on human health do not always protect other species. To begin to assess the potential ecological risk of DU release to the environment we modeled DU transport through the principalmore » components of the aquatic ecosystem at APG. We focused on the APG aquatic system because of the close proximity of the Chesapeake Bay and concerns about potential impacts on this ecosystem. Our objective in using a model to estimate environmental fate of DU is to ultimately reduce the uncertainty about predicted ecological risks due to DU from APG. The model functions to summarize information on the structure and functional properties of the APG aquatic system, to provide an exposure assessment by estimating the fate of DU in the environment, and to evaluate the sources of uncertainty about DU transport.« less

Ecological risk assessment of depleted uranium in the environment at Aberdeen Proving Ground. Annual report, 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clements, W.H.; Kennedy, P.L.; Myers, O.B.

1993-03-01

A preliminary ecological risk assessment was conducted to evaluate the effects of depleted uranium (DU) in the Aberdeen Proving Ground (APG) ecosystem and its potential for human health effects. An ecological risk assessment of DU should include the processes of hazard identification, dose-response assessment, exposure assessment, and risk characterization. Ecological risk assessments also should explicitly examine risks incurred by nonhuman as well as human populations, because risk assessments based only on human health do not always protect other species. To begin to assess the potential ecological risk of DU release to the environment we modeled DU transport through the principalmore » components of the aquatic ecosystem at APG. We focused on the APG aquatic system because of the close proximity of the Chesapeake Bay and concerns about potential impacts on this ecosystem. Our objective in using a model to estimate environmental fate of DU is to ultimately reduce the uncertainty about predicted ecological risks due to DU from APG. The model functions to summarize information on the structure and functional properties of the APG aquatic system, to provide an exposure assessment by estimating the fate of DU in the environment, and to evaluate the sources of uncertainty about DU transport.« less

Traumatic Brain Injury in a Military Operational Setting (Le traumatisme cranien dans un cadre militaire operationnel)

DTIC Science & Technology

2015-01-01

la gestion du TCCL lié à un déploiement. Les objectifs de ce rapport étaient de : 1) Décrire la pratique clinique... de la projection de débris et à l’accélération/décélération ou rotation. L’impact sur la santé publique du TCCL lié à un déploiement sur tout...montré que le cours clinique du TCCL provoqué par une déflagration présente de forts parallèles avec ce qu’on constate dans la littérature sur le

Radiation and Electromagnetic Induction Data Fusion for Detection of Buried Radioactive Metal Waste - 12282

DOE Office of Scientific and Technical Information (OSTI.GOV)

Long, Zhiling; Wei, Wei; Turlapaty, Anish

2012-07-01

At the United States Army's test sites, fired penetrators made of Depleted Uranium (DU) have been buried under ground and become hazardous waste. Previously, we developed techniques for detecting buried radioactive targets. We also developed approaches for locating buried paramagnetic metal objects by utilizing the electromagnetic induction (EMI) sensor data. In this paper, we apply data fusion techniques to combine results from both the radiation detection and the EMI detection, so that we can further distinguish among DU penetrators, DU oxide, and non- DU metal debris. We develop a two-step fusion approach for the task, and test it with surveymore » data collected on simulation targets. In this work, we explored radiation and EMI data fusion for detecting DU, oxides, and non-DU metals. We developed a two-step fusion approach based on majority voting and a set of decision rules. With this approach, we fuse results from radiation detection based on the RX algorithm and EMI detection based on a 3-step analysis. Our fusion approach has been tested successfully with data collected on simulation targets. In the future, we will need to further verify the effectiveness of this fusion approach with field data. (authors)« less

Approches pour la reduction de l'impact de defaut dans le transport d'energie du parc eolien offshore via VSC-HVDC =

NASA Astrophysics Data System (ADS)

Benadja, Mounir

Dans ce travail est presente un systeme de generation d'energie d'un parc eolien offshore et un systeme de transport utilisant les stations VSC-HVDC connectees au reseau principal AC onshore. Trois configurations ont ete etudiees, modelisees et validees par simulation. Dans chacune des configurations, des contributions ameliorant les cotes techniques et economiques sont decrites ci-dessous : La premiere contribution concerne un nouvel algorithme MPPT (Maximum Power Point Tracking) utilise pour l'extraction de la puissance maximale disponible dans les eoliennes des parcs offshores. Cette technique d'extraction du MPPT ameliore le rendement energetique de la chaine de conversion des energies renouvelables notamment l'energie eolienne a petite et a grande echelles (parc eolien offshore) qui constitue un probleme pour les constructeurs qui se trouvent confrontes a developper des dispositifs MPPT simples, moins couteux, robustes, fiables et capable d'obtenir un rendement energetique maximal. La deuxieme contribution concerne la reduction de la taille, du cout et de l'impact des defauts electriques (AC et DC) dans le systeme construit pour transporter l'energie d'un parc eolien offshore (OWF) vers le reseau principal AC onshore via deux stations 3L-NPC VSCHVDC. La solution developpee utilise des observateurs non-lineaires bases sur le filtre de Kalman etendu (EKF). Ce filtre permet d'estimer la vitesse de rotation et la position du rotor de chacune des generatrices du parc eolien offshore et de la tension du bus DC de l'onduleur DC-AC offshore et des deux stations 3L-NPC-VSC-HVDC (offshore et onshore). De plus, ce developpement du filtre de Kalman etendu a permis de reduire l'impact des defauts AC et DC. Deux commandes ont ete utilisees, l'une (commande indirect dans le plan abc) avec EKF integre destinee pour controler le convertisseur DC-AC offshore et l'autre (commande d-q) avec EKF integre pour controler les convertisseurs des deux stations AC-DC et DC-AC tout en tenant compte des entrees de chacune des stations. L'integration des observateurs non-lineaires (EKF) dans le controle des convertisseurs permet de resoudre le probleme des incertitudes de mesure, des incertitudes dans la modelisation, en cas du dysfonctionnement ou de panne des capteurs de mesure ainsi que le probleme de l'impact des defauts (AC et DC) sur la qualite d'energie dans les systemes de transmission. Ces estimations contribuent a rendre le cout global du systeme moins cher et sa taille moins encombrante ainsi que la reduction de l'impact des defauts (AC et DC) sur le systeme. La troisieme contribution concerne la reduction de la taille, du cout et de l'impact des defauts electriques (AC et DC) dans le systeme construit pour transporter l'energie d'un parc eolien offshore (OWF) vers le reseau principal AC onshore via deux stations VSC-HVDC. La solution developpee utilise des observateurs non-lineaires bases sur le filtre de Kalman etendu (EKF). Ce filtre permet d'estimer la vitesse de rotation et la position du rotor de chacune des generatrices du parc eolien et de la tension du bus DC de l'onduleur DC-AC offshore. La contribution porte surtout sur le developpement des deux commandes des deux stations. La premiere, la commande non-lineaire modifiee pour controler le premier convertisseur de la station VSC-HVDC offshore assurant le transfert de la puissance generee par le parc eolien vers la station VSC-HVDC onshore. La deuxieme commande non-lineaire modifiee avec integration de la regulation de la tension du bus DC et de la commande a modele de reference adaptative (MRAC) pour la compensation des surintensites et surtensions durant les defauts AC et DC. On peut constater que lors d'un defaut AC au PCC (Point of Common Coupling) du cote reseau onshore, la profondeur de l'impact du defaut AC sur l'amplitude des courants du reseau principal AC onshore qui etait reduit a 60% par les travaux de recherche (Erlich, Feltes et Shewarega, 2014), comparativement a la nouvelle commande proposee MRAC qui reduit la profondeur de l'impact a 35%. Lors de l'apparition des defauts AC et DC, une reduction de l'impact des defauts sur l'amplitude des courants de reseau AC terrestre et du temps de reponse a ete observee et la stabilite du systeme a ete renforcee par l'utilisation de la commande adaptative basee sur le modele de reference MRAC. La quatrieme contribution concerne une nouvelle commande basee sur le mode de glissement (SM) appliquee pour la station VSC-HVDC qui relie le parc eolien offshore (OWF) au reseau principal AC. Ce parc est compose de dix eoliennes basees sur des generatrices synchrones a aimant permanent (VSWT/PMSGs) connectees en parallele et chacune est controlee par son propre convertisseur DC-DC. Une comparaison des performances entre la commande SM et de la commande non-lineaire avec des controleurs PI pour les deux conditions (presence et absence de defaut DC) a ete analysee et montre la superiorite de la commande par SM. Un prototype du systeme etudie a echelle reduite a ete realise et teste au laboratoire GREPCI en utilisant la carte dSPACE-DS1104 pour la validation experimentale. L'analyse et la simulation des systemes etudies sont developpees sous l'environnement Matlab/Simulink/Simpowersystem. Les resultats obtenus a partir des configurations developpees sont valides par simulation et par experimentation. Les performances sont tres satisfaisantes du point de vue reponse dynamique, reponse en regime permanent, stabilite du systeme et qualite de l'energie.

An observational cohort study of patients with newly diagnosed digital ulcer disease secondary to systemic sclerosis registered in the EUSTAR database.

PubMed

Brand, Monika; Hollaender, Rebecca; Rosenberg, Daniel; Scott, Martin; Hunsche, Elke; Tyndall, Alan; Denaro, Valentina; Carreira, Patricia; Varju, Cecilia; Gabrielli, Barbara; Zingarelli, Stefania; Caramaschi, Paola; Simic-Pasalic, Katarina; Müller-Ladner, Ulf; Vasile, Massimiliano; Mihai, Carina; Rosato, Edoardo; Vacca, Alessandra; Zenone, Thierry; Mohamed, Walid A; Ancuta, Codrina; Zampogna, Giuseppe; Rednic, Simona; Jabaar, Nadia; Belloli, Laura; Pozzi, Maria R; Foti, Rosario; Walker, Ulrich A

2015-01-01

This study describes clinical characteristics, prognostic factors, and quality of life in patients with newly diagnosed (incident) digital ulcers (DU). Observational cohort study of 189 consecutive SSc patients with incident DU diagnosis identified from the EUSTAR database (22 centres in 10 countries). Data were collected from medical charts and during one prospective visit between 01/2004 and 09/2010. Median age at DU diagnosis was 51 years, majority of patients were female (88%), and limited cutaneous SSc was the most common subtype (61%). At incident DU diagnosis, 41% of patients had one DU and 59% had ≥2 DU; at the prospective visit 52% had DU. Pulmonary arterial hypertension (PAH) and multiple DU at diagnosis were associated with presence of any DU at the prospective visit (odds ratios: 4.34 and 1.32). During the observation period (median follow-up was 2 years) 127 patients had ≥1 hospitalisation. The event rate of new DU per person-year was 0.66, of DU-associated complications was 0.10, and of surgical or diagnostic procedures was 0.12. At the prospective visit, patients with ≥1 DU reported impairment in daily activities by 57%, those with 0 DU by 37%. The mean difference between patients with or without DU in the SF-36 physical component was 2.2, and in the mental component 1.4. DU patients were not routinely prescribed endothelin receptor antagonists or prostanoids. This real world cohort demonstrates that DU require hospital admission, and impair daily activity. PAH and multiple DU at diagnosis were associated with future occurrence of DU.

Chemical toxicity and radioactivity of depleted uranium: The evidence from in vivo and in vitro studies.

PubMed

Asic, Adna; Kurtovic-Kozaric, Amina; Besic, Larisa; Mehinovic, Lejla; Hasic, Azra; Kozaric, Mirza; Hukic, Mirsada; Marjanovic, Damir

2017-07-01

The main aim of this review is to summarize and discuss the current state of knowledge on chemical toxicity and radioactivity of depleted uranium (DU) and their effect on living systems and cell lines. This was done by presenting a summary of previous investigations conducted on different mammalian body systems and cell cultures in terms of potential changes caused by either chemical toxicity or radioactivity of DU. In addition, the authors aimed to point out the limitations of those studies and possible future directions. The majority of both in vitro and in vivo studies performed using animal models regarding possible effects caused by acute or chronic DU exposure has been reviewed. Furthermore, exposure time and dose, DU particle solubility, and uranium isotopes as factors affecting the extent of DU effects have been discussed. Special attention has been dedicated to chromosomal aberrations, DNA damage and DNA breaks, as well as micronuclei formation and epigenetic changes, as DU has recently been considered a possible causative factor of all these processes. Therefore, this approach might represent a novel area of study of DU-related irradiation effects on health. Since different studies offer contradictory results, the main aim of this review is to summarize and briefly discuss previously obtained results in order to identify the current opinion on DU toxicity and radioactivity effects in relation to exposure type and duration, as well as DU properties. Copyright © 2017 Elsevier Inc. All rights reserved.

Stuxnet Recruits the Proteasome to Take Down Polycomb.

PubMed

Karch, François

2016-06-20

In this issue of Developmental Cell, Du et al. (2016) describe a gene named stuxnet that regulates Polycomb protein stability, thereby influencing the activity of the Polycomb-group repressive chromatin complexes. Copyright © 2016 Elsevier Inc. All rights reserved.

[Effect of electroacupuncture of "Xiaohai" (SI 8) and "Xiajuxu" (ST 39) on serum TNF-α and duodenal high mobility group protein B 1 levels in duodenal ulcer rats].

PubMed

Zhang, Hong; Wang, Zhen-zhen; Zhang, Yu-chen; Yang, Lu-jia; Deng, Shi-feng; Ai, Kun; Zhang, Zhi-ping

2015-02-01

To observe the effect of electroacupuncture (EA) stimulation of "Xiaohai" (SI 8) and "Xiajuxu" (ST 39) on serum TNF-α and duodenal high mobility group protein B 1 (HMGB 1) levels in rats with duodenal ulcer (DU), so as to analyze its underlying mechanism in improving DU. Forty SD rats were randomly divided into normal control, model, Xiaohai (SI 8) and Xiajuxu (ST 39) groups (n=10 in each group). The DU model was established by intramuscular injection of 10% Cysteamine hydrochloride (300 mg/kg), followed by taking water containing 1% Cysteamine hydrochloride for 48 h. EA (10 Hz/50 Hz, 1-3 mA) was applied to bilateral SI 8 and ST 39 for 30 min, once a day for 10 days. The DU score (0-5 score) was evaluated according to Moraes' method. Serum TNF-α content was determined by ELISA and duodenal HMGB 1 expression was measured by immunohistochemistry. Compared to the normal control group, the DU score, serum TNF-α content, and duodenal HMGB 1 expression level of the model group were significantly higher (P<0.01). Following EA intervention, the increased DU score, serum TNF-α content, and duodenal HMGB 1 expression level were considerably down-regulated in the two EA groups in comparison with the model group (P<0.01, P<0.05) except HMGB 1 in the SI 8 group (P>0.05), and the effect of EA of "Xiajuxu" (ST 39), the lower-He point, was remarkably superior to that of "Xiaohai" (SI 8) in reducing DU score and TNF-α content (P<0.01). EA stimulation of SI 8 and ST 39 can improve duodenal ulceration in DU rats, which may be related to its effect in down-regulating serum TNF-α and duodenal HMGB 1 expression. The therapeutic effect of ST 39 is markedly better than SI 8 in relieving duodenal ulceration.

A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula

PubMed Central

Zhang, Fangbo; Tang, Shihuan; Liu, Xi; Gao, Yibo; Wang, Yanping

2013-01-01

At the molecular level, it is acknowledged that a TCM formula is often a complex system, which challenges researchers to fully understand its underlying pharmacological action. However, module detection technique developed from complex network provides new insight into systematic investigation of the mode of action of a TCM formula from the molecule perspective. We here proposed a computational approach integrating the module detection technique into a 2-class heterogeneous network (2-HN) which models the complex pharmacological system of a TCM formula. This approach takes three steps: construction of a 2-HN, identification of primary pharmacological units, and pathway analysis. We employed this approach to study Shu-feng-jie-du (SHU) formula, which aimed at discovering its molecular mechanism in defending against influenza infection. Actually, four primary pharmacological units were identified from the 2-HN for SHU formula and further analysis revealed numbers of biological pathways modulated by the four pharmacological units. 24 out of 40 enriched pathways that were ranked in top 10 corresponding to each of the four pharmacological units were found to be involved in the process of influenza infection. Therefore, this approach is capable of uncovering the mode of action underlying a TCM formula via module analysis. PMID:24376467

Unparticle physics.

PubMed

Georgi, Howard

2007-06-01

I discuss some simple aspects of the low-energy physics of a nontrivial scale invariant sector of an effective field theory-physics that cannot be described in terms of particles. I argue that it is important to take seriously the possibility that the unparticle stuff described by such a theory might actually exist in our world. I suggest a scenario in which some details of the production of unparticle stuff can be calculated. I find that in the appropriate low-energy limit, unparticle stuff with scale dimension dU looks like a nonintegral number dU of invisible particles. Thus dramatic evidence for a nontrivial scale invariant sector could show up experimentally in missing energy distributions.

L'Equin du Pied dans un Contexte de Brulure Grave - Interet du Bilan Photographique

PubMed Central

Girbon, J.P.; Maligot, B.; Coiffier, E.; Gonzalez-Gutierrez, L.; Gaussorgues, C.; Lacroix, P.; Braye, F.

2008-01-01

Summary The incorrect position of the foot in talipes equinus is common in the framework of prolonged confinement to bed in a patient in deep sedation. In the context of severe burns, this incorrect position is difficult to prevent and its fixation by cutaneous shrinkage, which is often associated with a musculotendinous fibrosis, constitutes an important functional after-effect. The onset of talipes equinus is insidious and progressive, and it is therefore important to be watchful both in detection and in prevention. Regular photographic assessment makes it possible to predict its appearance and to take appropriate preventive or curative action. PMID:21991119

Just methods in revolting times

PubMed Central

Fine, Michelle

2016-01-01

ABSTRACT This article takes up the challenge of critical methods in “revolting times,” as we conduct qualitative research on (in)justice festering within repulsive inequality gaps, and yet surrounded by the thrill of radical social movements dotting the globe. I introduce a call for “critical bifocality,” a term coined by Lois Weis and myself, to argue for research designs that interrogate how history, structures, and lives shape, reveal, and refract the conditions we study. Borrowing from critical researchers long gone, W. E. B. Du Bois in his text The Philadelphia Negro and Marie Jahoda in her stunning case study Marienthal, I offer up a set of epistemological muddles and methodological experiments, hoping to incite a conversation about our responsibilities as critical psychologists in deeply contentious times, refusing downstream analyses and resurrecting instead what Edward Said called “lost causes.” PMID:27812314

Argonne's 2012 Earth Day Event

ScienceCinema

Roberts, Jeff; Luck, Bill; Lynch, Peter; Lambiase,

2018-05-30

Argonne's 2012 Earth Day event drew crowds from across the laboratory. Argonne and U.S. Department of Energy employees toured booths and interactive displays set up by Argonne programs and clubs. Several of Argonne's partners participated, including U.S. Department of Energy, University of Chicago, Abri Credit Union, DuPage County Forest Preserve, DuPage Water Commission, PACE and Morton Arboretum. Argonne scientists and engineers also participated in a poster session, discussing their clean energy research.

Cost Structure and Life Cycle Cost (LCC) for Military Systems (structures de couts globaux de possession (LCC) pour systemes militaires)

DTIC Science & Technology

2003-06-01

variables. Dans le plan (p = 2), la méthode de régression linéaire ajuste au nuage de points une droite qui minimise la somme des écarts au carré entre...cohérence de la définition du produit. Par exemple, pour un blindé, il faut valider l ’ « harmonie » du trio masse, puissance du moteur et vitesse maximale. Il...en condition opérationnelle. De façon plus générale, la DGA devrait s’orienter vers l ‘élaboration et l’acquisition de modèle d’estimation de coûts du

Technology Demonstration Summary. DuPont/Oberlin Microfiltration System. Palmerton, Pennsylvania (EPA/540/S5-90/007)

EPA Science Inventory

In April and May 1990, the U.S. Environmental Protection Agency (EPA), under the Superfund Innovative Technology Evaluation (SITE) program, demonstrated DuPont/Oberlin's microfiltration system at the Palmerton Zinc Superfund (PZS) site In Palmerton, Pennsylvania. The microfiltr...

Graphs as a Managerial Tool: A Case Study of Du Pont's Use of Graphs in the Early Twentieth Century.

ERIC Educational Resources Information Center

Yates, JoAnne

1985-01-01

Sketches the development of business graphs in America. Examines their early use at Du Pont and the origin of the chart room around 1920, an important factor in the executive control systems at Du Pont. Draws lessons from this case study for managers and teachers of business communication. (PD)

Modélisation d'un transformateur à shunts magnétiques utilisé dans l'alimentation H.T. d'un générateur micro-ondes à magnétron

NASA Astrophysics Data System (ADS)

Chraygane, Mohamed; Teissier, Maurice; Jammal, Ahmad; Masson, Jean-Pierre

1994-11-01

The high voltage power supply for magnetron, used for the modular microwave generators in industrial applications, is of a classical design : a single phase leakage flux transformer supplying a cell, composed of a capacitor and a diode, which multiplies the voltage and stabilizes the current. A π model of this transformer is developed, taking the saturation phenomena and the stabilization process of the magnetron current into account. Three inductances are characterized by the non linear relations between flux and magnetizing current. This model was tested by E.M.T.P. software (Electro-Magnetic Transients Program), near the nominal state. The theoretical results were compared to experimental measurements with a good agreement. L'alimentation haute tension des magnétrons, utilisés comme source d'énergie microondes dans l'industrie, est de conception classique : un transformateur monophasé à fuites magnétiques alimentant une cellule doubleuse de tension et stabilisatrice de courant. Un schéma équivalent en π du transformateur est présenté, prenant en compte la saturation des différentes parties du fer et la stabilisation du courant du magnétron. Trois inductances sont caractérisées par les relations non linéaires entre flux et courant magnétisant. Ce modèle a été testé à l'aide du logiciel de calcul E.M.T.P. (Electro-Magnetic Transients Program), au voisinage du régime nominal. Les résultats théoriques, comparés aux mesures expérimentales, se trouvent en bon accord avec elles.

Âge 40K/ 40Ar, Carbonifère inférieur, du magmatisme basique filonien du synclinal paléozoïque de Tin Serririne, Sud-Est du Hoggar (Algérie)

NASA Astrophysics Data System (ADS)

Djellit, Hamou; Bellon, Hervé; Ouabadi, Aziouz; Derder, Mohamed E. M.; Henry, Bernard; Bayou, Boualem; Khaldi, Allaoua; Baziz, Kamal; Merahi, Mounir K.

2006-07-01

Palaeozoic formations of the Tassilis Oua-n-Ahaggar (southeastern Hoggar) include magmatic rocks in the Tin Serririne syncline. Slight contact metamorphism of the overlying bed and studies of anisotropy of magnetic susceptibility of these rocks show that the latter correspond to sills and NW-SE or north-south dykes. 40K/ 40Ar dating of separated feldspars and whole rock for one sample and of whole rock for two other samples give a mean age of 347.6±16.2Ma (at the 2- σ level), thus corresponding to a Lower Carboniferous (Tournaisian) age. Taking into account both the age of this magmatism and the stratigraphic and structural data for this region suggests that dolerites were emplaced within distensive zones that are related to the reactivation of Panafrican faults. To cite this article: H. Djellit et al., C. R. Geoscience 338 (2006).

Gestion des ressources hydriques adaptee aux changements climatiques pour la production optimale d'hydroelectricite. Etude de cas: Bassin versant de la riviere Manicouagan

NASA Astrophysics Data System (ADS)

Haguma, Didier

Il est dorenavant etabli que les changements climatiques auront des repercussions sur les ressources en eau. La situation est preoccupante pour le secteur de production d'energie hydroelectrique, car l'eau constitue le moteur pour generer cette forme d'energie. Il sera important d'adapter les regles de gestion et/ou les installations des systemes hydriques, afin de minimiser les impacts negatifs et/ou pour capitaliser sur les retombees positives que les changements climatiques pourront apporter. Les travaux de la presente recherche s'interessent au developpement d'une methode de gestion des systemes hydriques qui tient compte des projections climatiques pour mieux anticiper les impacts de l'evolution du climat sur la production d'hydroelectricite et d'etablir des strategies d'adaptation aux changements climatiques. Le domaine d'etude est le bassin versant de la riviere Manicouagan situe dans la partie centrale du Quebec. Une nouvelle approche d'optimisation des ressources hydriques dans le contexte des changements climatiques est proposee. L'approche traite le probleme de la saisonnalite et de la non-stationnarite du climat d'une maniere explicite pour representer l'incertitude rattachee a un ensemble des projections climatiques. Cette approche permet d'integrer les projections climatiques dans le probleme d'optimisation des ressources en eau pour une gestion a long terme des systemes hydriques et de developper des strategies d'adaptation de ces systemes aux changements climatiques. Les resultats montrent que les impacts des changements climatiques sur le regime hydrologique du bassin de la riviere Manicouagan seraient le devancement et l'attenuation de la crue printaniere et l'augmentation du volume annuel d'apports. L'adaptation des regles de gestion du systeme hydrique engendrerait une hausse de la production hydroelectrique. Neanmoins, une perte de la performance des installations existantes du systeme hydrique serait observee a cause de l'augmentation des deversements non productibles dans le climat futur. Des strategies d'adaptation structurale ont ete analysees pour augmenter la capacite de production et la capacite d'ecoulement de certaines centrales hydroelectriques afin d'ameliorer la performance du systeme. Une analyse economique a permis de choisir les meilleures mesures d'adaptation et de determiner le moment opportun pour la mise en oeuvre de ces mesures. Les resultats de la recherche offrent aux gestionnaires des systemes hydriques un outil qui permet de mieux anticiper les consequences des changements climatiques sur la production hydroelectrique, incluant le rendement de centrales, les deversements non productibles et le moment le plus opportun pour inclure des modifications aux systemes hydriques. Mots-cles : systemes hydriques, adaptation aux changements climatiques, riviere Manicouagan

A review of the environmental corrosion, fate and bioavailability of munitions grade depleted uranium.

PubMed

Handley-Sidhu, Stephanie; Keith-Roach, Miranda J; Lloyd, Jonathan R; Vaughan, David J

2010-11-01

Depleted uranium (DU) is a by-product of nuclear fuel enrichment and is used in antitank penetrators due to its high density, self-sharpening, and pyrophoric properties. Military activities have left a legacy of DU waste in terrestrial and marine environments, and there have been only limited attempts to clean up affected environments. Ten years ago, very little information was available on the dispersion of DU as penetrators hit their targets or the fate of DU penetrators left behind in environmental systems. However, the marked increase in research since then has improved our knowledge of the environmental impact of firing DU and the factors that control the corrosion of DU and its subsequent migration through the environment. In this paper, the literature is reviewed and consolidated to provide a detailed overview of the current understanding of the environmental behaviour of DU and to highlight areas that need further consideration. Copyright © 2010 Elsevier B.V. All rights reserved.

Taking Care of Business: Walter Carpenter and the Management of American Enterprise.

ERIC Educational Resources Information Center

Cheape, Charles W.

1996-01-01

Evaluates the life and career of DuPont corporate executive, Walter Carpenter, and uses it to illustrate the rise of the managerial class. Neither owners nor entrepreneurs, managers like Carpenter used their intelligence and skill to reorganize and expand the companies the companies where they worked. (MJP)

Application of Mathematical Signal Processing Techniques to Mission Systems. (l’Application des techniques mathematiques du traitement du signal aux systemes de conduite des missions)

DTIC Science & Technology

1999-11-01

represents the linear time invariant (LTI) response of the combined analysis /synthesis system while the second repre- sents the aliasing introduced into...effectively to implement voice scrambling systems based on time - frequency permutation . The most general form of such a system is shown in Fig. 22 where...92201 NEUILLY-SUR-SEINE CEDEX, FRANCE RTO LECTURE SERIES 216 Application of Mathematical Signal Processing Techniques to Mission Systems (1

Pathogenesis of duck circovirus genotype 1 in experimentally infected Pekin ducks.

PubMed

Hong, Y-T; Kang, M; Jang, H-K

2018-05-17

Ducks infected with duck circovirus (DuCV) exhibit feathering disorder, growth retardation, and low body weight. The virus can induce immunosuppression and increase rates of infection caused by other pathogens. The purpose of the present study was to investigate the pathogenesis of DuCV in experimentally infected Pekin ducks. At postmortem examination, gross lesions were observed in the immune organs including bursa of Fabricius (BF), thymus, and spleen. Hemorrhage, lymphocytic depletion, necrosis, and degeneration were observed in the bursal tissues by histological examination. The TUNEL assay was performed with bursal tissue. There was a significant difference of the apoptosis rate between the negative and DuCV-infected ducks. The earliest time point for detection of DuCV DNA in sera, cloacal swabs, and organs was 1 wk post-infection (WPI). Viral shedding was persistent and detectable at the end of the experiment (10 WPI). The findings provide evidence that horizontal transmission and persistent infection are the characteristics of DuCV. The organ with the highest mean viral load was the spleen, followed by BF, cecal tonsil, lung, thymus, liver, and kidney. We successfully established an experimental DuCV genotype 1 (DuCV-1) infection in Pekin ducks and demonstrated the pathogenicity and persistence of DuCV-1. In conclusion, DuCV-1 caused extensive damage to the immune organs that may have resulted in immunosuppression. Pathobiological characteristics of DuCV-1 include systemic infection, persistent infection, and horizontal transmission. These features allow DuCV-1 to circulate more easily in farms and increase the susceptibility of ducks to other diseases.

PHOTOMETRIC ANALYSIS OF HS Aqr, EG Cep, VW LMi, AND DU Boo

DOE Office of Scientific and Technical Information (OSTI.GOV)

Djurasevic, G.; Latkovic, O.; Bastuerk, Oe.

2013-03-15

We analyze new multicolor light curves for four close late-type binaries: HS Aqr, EG Cep, VW LMi, and DU Boo, in order to determine the orbital and physical parameters of the systems and estimate the distances. The analysis is done using the modeling code of G. Djurasevic, and is based on up-to-date measurements of spectroscopic elements. All four systems have complex, asymmetric light curves that we model by including bright or dark spots on one or both components. Our findings indicate that HS Aqr and EG Cep are in semi-detached, while VW LMi and DU Boo are in overcontact configurations.

[Effect of immunity in patients of duodenal ulcer deseases and the influence on its eradication and immunomodulational therapy in condtions rezbublic Uzbekistan].

PubMed

Suleĭmanov, S F

2008-01-01

The parameters systems of immunity was analyzed in 56 patients with duodenal ulcer (DU) and 36 healthy persons. The suppression of T-system and its subsets, a tension of humoral link of immunity was observed in patient. The use traditional method of treatmend was not made a result to disorder of second immunodificiency in patients with DU (group 1). The usage of immunomoduline, the dose of which was 1.0-1.2 mg (in one course) at second group patients (n=24) with DU cured immune disorder, increased cell immunity, and had immunocorrection and eradication features.

Molecular cloning and functional characterization of duck nucleotide-binding oligomerization domain 1 (NOD1).

PubMed

Li, Huilin; Jin, Hui; Li, Yaqian; Liu, Dejian; Foda, Mohamed Frahat; Jiang, Yunbo; Luo, Rui

2017-09-01

Nucleotide-binding oligomerization domain 1 (NOD1) is an imperative cytoplasmic pattern recognition receptor (PRR) and considered as a key member of the NOD-like receptor (NLR) family which plays a critical role in innate immunity through sensing microbial components derived from bacterial peptidoglycan. In the current study, the full-length of duck NOD1 (duNOD1) cDNA from duck embryo fibroblasts (DEFs) was cloned. Multiple sequence alignment and phylogenetic analysis demonstrated that duNOD1 exhibited a strong evolutionary relationship with chicken and rock pigeon NOD1. Tissue-specific expression analysis showed that duNOD1 was widely distributed in various organs, with the highest expression observed in the liver. Furthermore, duNOD1 overexpression induced NF-κB activation in DEFs and the CARD domain is crucial for duNOD1-mediated NF-κB activation. In addition, silencing the duNOD1 decreased the activity of NF-κB in DEFs stimulated by iE-DAP. Overexpression of duNOD1 significantly increased the expression of TNF-α, IL-6, and RANTES in DEFs. These findings highlight the crucial role of duNOD1 as an intracellular sensor in duck innate immune system. Copyright © 2017 Elsevier Ltd. All rights reserved.

Gulf war depleted uranium risks.

PubMed

Marshall, Albert C

2008-01-01

US and British forces used depleted uranium (DU) in armor-piercing rounds to disable enemy tanks during the Gulf and Balkan Wars. Uranium particulate is generated by DU shell impact and particulate entrained in air may be inhaled or ingested by troops and nearby civilian populations. As uranium is slightly radioactive and chemically toxic, a number of critics have asserted that DU exposure has resulted in a variety of adverse health effects for exposed veterans and nearby civilian populations. The study described in this paper used mathematical modeling to estimate health risks from exposure to DU during the 1991 Gulf War for both US troops and nearby Iraqi civilians. The analysis found that the risks of DU-induced leukemia or birth defects are far too small to result in an observable increase in these health effects among exposed veterans or Iraqi civilians. The analysis indicated that only a few ( approximately 5) US veterans in vehicles accidentally targeted by US tanks received significant exposure levels, resulting in about a 1.4% lifetime risk of DU radiation-induced fatal cancer (compared with about a 24% risk of a fatal cancer from all other causes). These veterans may have also experienced temporary kidney damage. Iraqi children playing for 500 h in DU-destroyed vehicles are predicted to incur a cancer risk of about 0.4%. In vitro and animal tests suggest the possibility of chemically induced health effects from DU internalization, such as immune system impairment. Further study is needed to determine the applicability of these findings for Gulf War exposure to DU. Veterans and civilians who did not occupy DU-contaminated vehicles are unlikely to have internalized quantities of DU significantly in excess of normal internalization of natural uranium from the environment.

Mesure et retroaction sur un qubit multi-niveaux en electrodynamique quantique en circuit non lineair

NASA Astrophysics Data System (ADS)

Boissonneault, Maxime

L'electrodynamique quantique en circuit est une architecture prometteuse pour le calcul quantique ainsi que pour etudier l'optique quantique. Dans cette architecture, on couple un ou plusieurs qubits supraconducteurs jouant le role d'atomes a un ou plusieurs resonateurs jouant le role de cavites optiques. Dans cette these, j'etudie l'interaction entre un seul qubit supraconducteur et un seul resonateur, en permettant cependant au qubit d'avoir plus de deux niveaux et au resonateur d'avoir une non-linearite Kerr. Je m'interesse particulierement a la lecture de l'etat du qubit et a son amelioration, a la retroaction du processus de mesure sur le qubit de meme qu'a l'etude des proprietes quantiques du resonateur a l'aide du qubit. J'utilise pour ce faire un modele analytique reduit que je developpe a partir de la description complete du systeme en utilisant principalement des transfprmations unitaires et une elimination adiabatique. J'utilise aussi une librairie de calcul numerique maison permettant de simuler efficacement l'evolution du systeme complet. Je compare les predictions du modele analytique reduit et les resultats de simulations numeriques a des resultats experimentaux obtenus par l'equipe de quantronique du CEASaclay. Ces resultats sont ceux d'une spectroscopie d'un qubit supraconducteur couple a un resonateur non lineaire excite. Dans un regime de faible puissance de spectroscopie le modele reduit predit correctement la position et la largeur de la raie. La position de la raie subit les decalages de Lamb et de Stark, et sa largeur est dominee par un dephasage induit par le processus de mesure. Je montre que, pour les parametres typiques de l'electrodynamique quantique en circuit, un accord quantitatif requiert un modele en reponse non lineaire du champ intra-resonateur, tel que celui developpe. Dans un regime de forte puissance de spectroscopie, des bandes laterales apparaissent et sont causees par les fluctuations quantiques du champ electromagnetique intra-resonateur autour de sa valeur d'equilibre. Ces fluctuations sont causees par la compression du champ electromagnetique due a la non-linearite du resonateur, et l'observation de leur effet via la spectroscopie d'un qubit constitue une premiere. Suite aux succes quantitatifs du modele reduit, je montre que deux regimes de parametres ameliorent marginalement la mesure dispersive d'un qubit avec un resonateur lineaire, et significativement une mesure par bifurcation avec un resonateur non lineaire. J'explique le fonctionnement d'une mesure de qubit dans un resonateur lineaire developpee par une equipe experimentale de l'Universite de Yale. Cette mesure, qui utilise les non-linearites induites par le qubit, a une haute fidelite, mais utilise une tres haute puissance et est destructrice. Dans tous ces cas, la structure multi-niveaux du qubit s'avere cruciale pour la mesure. En suggerant des facons d'ameliorer la mesure de qubits supraconducteurs, et en decrivant quantitativement la physique d'un systeme a plusieurs niveaux couple a un resonateur non lineaire excite, les resultats presentes dans cette these sont pertinents autant pour l'utilisation de l'architecture d'electrodynamique quantique en circuit pour l'informatique quantique que pour l'optique quantique. Mots-cles: electrodynamique quantique en circuit, informatique quantique, mesure, qubit supraconducteur, transmon, non-linearite Kerr

Report of the National Sub-Committee to the Interprovincial Standards Program Coordinating Committee on the Interprovincial Computerized Examination Management System=Rapport du Sous-Comite National presente au Comite de Coordination du Programme de Normes Interprovincials sur le systeme de gestion des examens informatises interprovinciaux.

ERIC Educational Resources Information Center

New Brunswick Dept. of Advanced Education and Training, Fredericton. Interprovincial Standards Program Coordinating Committee.

In January 1985, Employment and Immigration Canada funded a pilot project in New Brunswick for the development and testing of an Interprovincial Computerized Examination Management (ICEM) System. The resulting system is comprised of a dual interprovincial and provincial item bank facility, a software component offering the option of computerized…

Depleted uranium exposure and health effects in Gulf War veterans

PubMed Central

Squibb, Katherine S; McDiarmid, Melissa A

2006-01-01

Health effects stemming from depleted uranium (DU) exposure in a cohort of Gulf War veterans who were in or on US Army vehicles hit by friendly fire involving DU munitions are being carefully monitored through the Baltimore Veterans Affairs (VA) DU Follow-Up Program initiated in 1993. DU exposure in this cohort has been directly measured using inductively coupled plasma-mass spectrometer (ICP-MS) isotopic analysis for DU in urine specimens. Soldiers with embedded DU fragments continue to excrete elevated concentrations of U in their urine, documenting ongoing systemic exposure to U released from their fragments. Biennial surveillance visits provide a detailed health assessment that includes basic clinical measures and surveillance for early changes in kidney function, an expected target organ for U. Tests also include measurements of genotoxicity and neuroendocrine, neurocognitive and reproductive function. With the exception of the elevated urine U excretion, no clinically significant expected U-related health effects have been identified to date. Subtle changes in renal function and genotoxicity markers in veterans with urine U concentrations greater than 0.1 μg−1 creatinine, however, indicate the need for continued surveillance of these DU-exposed veterans. PMID:16687268

Insights into Action: Successful School Leaders Share What Works

ERIC Educational Resources Information Center

Sterrett, William L.

2011-01-01

What does it take to be a great school leader? An award-winning former principal poses this question to renowned school leaders and experts in the field to provide you with insight into the actions that lead to success. These giants in the field of educational leadership--including Baruti Kafele, Rick DuFour, Carol Ann Tomlinson, and James…

Words Du Jour: An Analysis of Traditional and Transitional Course Descriptors at Select J-Schools

ERIC Educational Resources Information Center

Spillman, Mary; Kuban, Adam J.; Smith, Suzy J.

2017-01-01

Journalism education may be at a tipping point. It is unclear, however, what new form curricula might take. Through an analysis of individual course titles and descriptions that appeared in the 2013-2014 undergraduate catalogs of 68 selected universities, this exploratory study finds that most departments/schools are not offering classes that…

Perspectives/Taking Stock of the Teaching Life

ERIC Educational Resources Information Center

Scherer, Marge

2016-01-01

Although they may not have to confront the physical dangers fire fighters, and pilots face every day, teachers, principals, and administrators are responsible for many children and to many adults, our authors note (Tomlinson, Danielson, DuFour, Collins, Anderson). What teachers do or don't do affects the well-being of many and they have to make…

Brought-Along Identities and the Dynamics of Ideology: Accomplishing Bivalent Stances in a Multilingual Interaction

ERIC Educational Resources Information Center

Williams, Ashley M.

2008-01-01

This paper examines how the interconnected aspects of the stance triangle (Du Bois 2007) allow speakers to tap into multiple ideological layers as they take a stance and reveal intra-ethnic group tensions. Using a detailed interaction analysis of a Chinese American family's multilingual interaction, the paper explores how such ideological dynamics…

Study of the Tributyl Phosphate--30 Percent Dodecane Solvent; ETUDE DU SOLVANT PHOSPHATE TRIBUTYLIQUE 30 PERCENT--DODECANE (in French)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leroy, P.

1967-07-01

This study, originating mainly from a literature survey, gives the principal chemical and physical features of the tributyl-phosphate (TBP) agent diluted at 30 volumes per cent in dodecane. The mixture is a very commonly used extractant in nuclear fuel processing. In this paper, the main following points are reported: -) the components (TBP and diluents) -) the TBP-diluents systems (non-loaded), -) the TBP-diluents-water systems, -) TBP-diluents-water-nitric acid systems, and -) industrial solvents. (author) [French] Cette etude, d'origine bibliographique, regroupe les caracteristiques physico-chimiques essentielles du phosphate tributylique (TBP) dilue a 30% en volume dans du dodecane. Ce melange constitue un agentmore » d'extraction tres utilise dans le traitement des combustibles nucleaires. Les principaux points traites sont les suivants: -) les constituants (TBP et diluants), -) les systemes TBP-diluants non charges, -) les systemes TBP-diluants-eau, -) les systemes TBP-diluants-eau-acide nitrique, et -) les solvants industriels. (auteur)« less

Modèle tridimensionnel pour coupler les équations magnétiques et électriques dans le cas de la magnétostatique

NASA Astrophysics Data System (ADS)

Piriou, F.; Razek, A.

1991-03-01

In this paper a 3D model for coupling of magnetic and electric equations is presented. The magnetic equations are solved with the help of finite element method using the magnetic vector potential formulation. To take into account the effects of magnetic saturation we use the Newton-Raphson algorithm. We develop the analysis permitting the coupling of magnetic and electric equations to obtain a difrerential system equations which can be solved with numerical integration. As example we model an iron core coil and the validity of our model is verified by a comparison of the obtained results with an analytical solution and a 2D code calculation. Dans cet article est présenté un modèle 3D qui permet de coupler les équations magnétiques et électriques. Les équations magnétiques sont résolues à l'aide de la méthode des éléments finis en utilisant une formulation en potentiel vecteur magnétique. Dans le modèle proposé les effets de la saturation du circuit magnétique sont pris en compte en utilisant l'algorithme de Newton-Raphson. On montre comment relier les équations magnétiques avec celles du circuit électrique pour aboutir à un système d'équations différentielles que l'on résout avec une intégration numérique. A titre d'exemple on modélise une bobine à noyau ferromagnétique et pour montrer la validité du modèle on compare les résultats obtenus avec une solution analytique et un code de calcul 2D.

Basie Instrumentation of a Low Speed Axial Compressor

NASA Astrophysics Data System (ADS)

Blidi, Sami; Miton, Hubert

1995-07-01

The flow modelling depending on test results allows a best aerodynamic comprehension. For this reason, a test bed of L.E.M.F.I.'s axial compressor has been set and instrumented for a detailed exploration of the flow in a four-stage turbomachine characterised by a little spacing between blade rows. In this paper, first are given brief descriptions of the geometrical characteristics of this compressor, the test bed's control system operation and the instrumentation set. Next, measures for the exploration of flow are discussed. Finally, typical results concerning the global and local performance measurements and their analysis are presented. This work permitted to instrument the L.E.M.F.I.'s four-stage axial compressor test bed and obtain the flow steady and unsteady characteristics using the five-hole and hot film probes. Les études de modélisation de l'écoulement dans les compresseurs axiaux doivent s'appuyer sur des résultats expérimentaux permettant une meilleure compréhension des phénomènes aérodynamiques et convenant à la validation des codes numériques. À cette fin, un banc d'essais de compresseur axial basse vitesse a été rais au point et instrumenté au L.E.M.F.I.[1] pour des explorations détaillées de l'écoulement dans une machine comportant 4étages, caractérisée par le faible espacement entre les rangées d'aubages. Dans cet article, nous décrivons brièvement les caractéristiques géométriques du compresseur axial, les systèmes de contrôle du fonctionnement du banc d'essais et l'instrumentation mise au point. Nous parlons ensuite des moyens d'explorations de l'écoulement utilisés. Nous fournissons enfin des exemples de résultats de mesure des performances globales et locales du compresseur et analysons brièvement ces résultats. Le travail effectué a permis de mettre au point et d'instrumenter un banc d'essais de compresseur axial basse vitesse au L.E.M.F.I. et rendu possible la détermination des grandeurs stationnaires et instationnaires de l'écoulement entre les rangées d'aubages en utilisant des sondes clinométriques de pression et des sondes à films chauds.

Assessing the performance of regional landslide early warning models: the EDuMaP method

NASA Astrophysics Data System (ADS)

Calvello, M.; Piciullo, L.

2015-10-01

The paper proposes the evaluation of the technical performance of a regional landslide early warning system by means of an original approach, called EDuMaP method, comprising three successive steps: identification and analysis of the Events (E), i.e. landslide events and warning events derived from available landslides and warnings databases; definition and computation of a Duration Matrix (DuMa), whose elements report the time associated with the occurrence of landslide events in relation to the occurrence of warning events, in their respective classes; evaluation of the early warning model Performance (P) by means of performance criteria and indicators applied to the duration matrix. During the first step, the analyst takes into account the features of the warning model by means of ten input parameters, which are used to identify and classify landslide and warning events according to their spatial and temporal characteristics. In the second step, the analyst computes a time-based duration matrix having a number of rows and columns equal to the number of classes defined for the warning and landslide events, respectively. In the third step, the analyst computes a series of model performance indicators derived from a set of performance criteria, which need to be defined by considering, once again, the features of the warning model. The proposed method is based on a framework clearly distinguishing between local and regional landslide early warning systems as well as among correlation laws, warning models and warning systems. The applicability, potentialities and limitations of the EDuMaP method are tested and discussed using real landslides and warnings data from the municipal early warning system operating in Rio de Janeiro (Brazil).

Anti-inflammatory and carbonic anhydrase restoring actions of yam powder (Dioscorea spp) contribute to the prevention of cysteamine-induced duodenal ulcer in a rat model.

PubMed

Park, Jong-Min; Kim, Yoon-Jae; Kim, Ju-Seung; Han, Young-Min; Kangwan, Napapan; Hahm, Ki Baik; Kim, Tae-Sok; Kwon, Oran; Kim, Eun-Hee

2013-08-01

Increased acid output, accompanied with a defective defense system, is considered a fundamental pathogenesis of duodenal ulcer (DU). However, relapse of DU occurs despite proton pump inhibitors and H2 receptor antagonists, hence imposing the enforcement of the defense system. Dried powder of the yam tuber (Dioscorea spp) has been used in traditional folk medicine as a nutritional fortification. We hypothesized that dried-yam powder would prevent DU through improvement of anti-inflammatory actions and carbonic anhydrase (CA) activity. Therefore, we investigated the preventive effects of dried-yam powder against the cysteamine-induced DU and elucidated the underlying mechanisms. Duodenal ulcers were induced in Sprague-Dawley rats by intragastric administration of 500 mg/kg cysteamine-HCl. The dried-yam powder was used as a pretreatment before the cysteamine-HCl. The number and size of DU were measured. The expressions of inflammation mediators were checked in duodenal tissues, and the expressions of CAs and malondialdehyde levels were also examined. Cysteamine provoked perforated DU, whereas dried-yam powder significantly prevented DU as much as pantoprazole and significantly reduced the incidence of perforation. The messenger RNA expressions of cyclooxygenase-2 and inducible nitric oxide synthase were remarkably decreased in the yam group compared with the cysteamine group, and the serum levels of proinflammatory cytokines including interleukin-1β, interleukin-6, and tumor necrosis factor were significantly attenuated in the yam group. Cysteamine significantly decreased the expression of CAs, whereas yam treatment significantly preserved the expressions of CA IX, XII, and XIV. In conclusion, dried-yam powder exerts a significant protective effect against cysteamine-induced DU by lowering the activity of inflammatory cytokines and free radicals and restoring the activity of CAs, except in CA IV. Copyright © 2013 Elsevier Inc. All rights reserved.

Differences between recalculated and original Dobson total ozone data from Hradec Kralove, Czechoslovakia, 1962-1990

NASA Technical Reports Server (NTRS)

Vanicek, Karel

1994-01-01

Backward reevaluation of long-term total ozone measurements from the Solar and Ozone Observatory of Czech Hydrometeorological Institute at Hradec Kralove, Czechoslovakia, was performed for the period 1962-1990. The homogenization was carried out with respect to the calibration level of the World Primary Standard Spectrophotometer No. 83 - WPSS by means of day-by-day recalculations of more than 25,000 individual measurements using the R-N tables reconstructed after international comparisons and regular standard lamp tests of the Dobson spectrophotometer No. 74. The results showed significant differences among the recalculated data and those original ones published in the bulletins Ozone Data for the World. In the period 1962-1979 they reached 10-19 D.U. (3.0-5.5%) for annual averages and even 26 D.U. (7.0%) for monthly averages of total ozone. Such differences exceed several times accuracy of measuring and can significantly influence character of trends of total ozone in Central Europe. Therefore the results from Hradec Kralove support the calls for reevaluation of all historical Dobson total ozone data sets at individual stations of Global Ozone Observing System.

Modeling of the 6DOF Missile Dynamics using the NED Axes System

DTIC Science & Technology

1997-08-01

representer le corps du missile, l’autodirecteur ainsi que Ia ligne missile-but. Le systeme d’axes le plus couramment utilise dans le domaine de la ...simulation de missiles tactiques ainsi que dans la librairie de composantes de modele de simulation du CRDV est le systeme d’axes NED, qui utilise l’axe x...RESEARCH ESTABLISHMENT CENTRE DE RECHERCHES POUR LA DEFENSE VALCARTIER,QuEBEC DREV- N-9703 MODELING OF THE 6DOF MISSILE DYNAMICS USING THE NED AXES

Digital ulcers and cutaneous subsets of systemic sclerosis: Clinical, immunological, nailfold capillaroscopy, and survival differences in the Spanish RESCLE Registry.

PubMed

Tolosa-Vilella, Carles; Morera-Morales, Maria Lluisa; Simeón-Aznar, Carmen Pilar; Marí-Alfonso, Begoña; Colunga-Arguelles, Dolores; Callejas Rubio, José Luis; Rubio-Rivas, Manuel; Freire-Dapena, Maika; Guillén-Del Castillo, Alfredo; Iniesta-Arandia, Nerea; Castillo-Palma, Maria Jesús; Egurbide-Arberas, Marivi; Trapiellla-Martínez, Luis; Vargas-Hitos, José A; Todolí-Parra, José Antonio; Rodriguez-Carballeira, Mónica; Marin-Ballvé, Adela; Pla-Salas, Xavier; Rios-Blanco, Juan José; Fonollosa-Pla, Vicent

2016-10-01

Digital ulcers (DU) are the most common vascular complication of systemic sclerosis (SSc). We compared the characteristics between patients with prior or current DU with those never affected and evaluated whether a history of DU may be a predictor of vascular, organ involvement, and/or death in patients with SSc. Data from SSc patients with or without prior or current DU were collected by 19 referral centers in an ongoing registry of Spanish SSc patients, named Registro de ESCLErodermia (RESCLE). Demographics, organ involvement, autoimmunity features, nailfold capillary pattern, survival time, and causes of death were analyzed to identify DU related characteristics and survival of the entire series and according to the following cutaneous subsets-diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc), and SSc sine scleroderma (ssSSc). Out of 1326, 552 patients enrolled in the RESCLE registry had prior or current DU, 88% were women, the mean age was 50 ± 16 years, and the mean disease duration from first SSc symptom was 7.6 ± 9.6 years. Many significant differences were observed in the univariate analysis between patients with and without prior/current DU. Multivariate analysis identified that history of prior/current DU in patients with SSc was independently associated to younger age at SSc diagnosis, diffuse cutaneous SSc, peripheral vascular manifestations such Raynaud's phenomenon, telangiectasia, and acro-osteolysis but no other vascular features such as pulmonary arterial hypertension or scleroderma renal crisis. DU was also associated to calcinosis cutis, interstitial lung disease, as well as worse survival. Multivariate analysis performed in the cutaneous subsets showed that prior/current DU were independently associated: (1) in dcSSc, to younger age at SSc diagnosis, presence of telangiectasia and calcinosis and rarely a non-SSc pattern on nailfold capillaroscopy; (2) in lcSSc, to younger age at SSc diagnosis, presence of Raynaud's phenomenon as well as calcinosis cutis, interstitial lung disease, and higher incidence of death from all causes; and (3) in ssSSc, to younger age at first SSc symptom and greater incidence of death from all causes. Digital ulcers develop in patients with SSc younger at diagnosis, mainly in patients with dcSSc and lcSSc, and they are associated to other peripheral vascular manifestations such as Raynaud's phenomenon, telangiectasia, and acro-osteolysis but also to calcinosis, and interstitial lung disease. History of DU in SSc leads to worse survival, also noticeable for lcSSc and ssSSc subsets but not for dcSSc patients. Copyright © 2016 Elsevier Inc. All rights reserved.

SU-G-IeP4-14: Prostate Brachytherapy Activity Measurement and Source Localization by Using a Dual Photon Emission Computed Tomography System: A Feasibility Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, C; Lin, H; Chuang, K

2016-06-15

Purpose: To monitor the activity distribution and needle position during and after implantation in operating rooms. Methods: Simulation studies were conducted to assess the feasibility of measurement activity distribution and seed localization using the DuPECT system. The system consists of a LaBr3-based probe and planar detection heads, a collimation system, and a coincidence circuit. The two heads can be manipulated independently. Simplified Yb-169 brachytherapy seeds were used. A water-filled cylindrical phantom with a 40-mm diameter and 40-mm length was used to model a simplified prostate of the Asian man. Two simplified seeds were placed at a radial distance of 10more » mm and tangential distance of 10 mm from the center of the phantom. The probe head was arranged perpendicular to the planar head. Results of various imaging durations were analyzed and the accuracy of the seed localization was assessed by calculating the centroid of the seed. Results: The reconstructed images indicate that the DuPECT can measure the activity distribution and locate the seeds dwelt in different positions intraoperatively. The calculated centroid on average turned out to be accurate within the pixel size of 0.5 mm. The two sources were identified when the duration is longer than 15 s. The sensitivity measured in water was merely 0.07 cps/MBq. Conclusion: Preliminary results show that the measurement of the activity distribution and seed localization are feasible using the DuPECT system intraoperatively. It indicates the DuPECT system has potential to be an approach for dose-distribution-validation. The efficacy of acvtivity distribution measurement and source localization using the DuPECT system will evaluated in more realistic phantom studies (e.g., various attenuation materials and greater number of seeds) in the future investigation.« less

Distributed utility technology cost, performance, and environmental characteristics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wan, Y; Adelman, S

1995-06-01

Distributed Utility (DU) is an emerging concept in which modular generation and storage technologies sited near customer loads in distribution systems and specifically targeted demand-side management programs are used to supplement conventional central station generation plants to meet customer energy service needs. Research has shown that implementation of the DU concept could provide substantial benefits to utilities. This report summarizes the cost, performance, and environmental and siting characteristics of existing and emerging modular generation and storage technologies that are applicable under the DU concept. It is intended to be a practical reference guide for utility planners and engineers seeking informationmore » on DU technology options. This work was funded by the Office of Utility Technologies of the US Department of Energy.« less

Correlative measurements of the stratospheric aerosols

NASA Astrophysics Data System (ADS)

Santer, R.; Brogniez, C.; Herman, M.; Diallo, S.; Ackerman, M.

1992-12-01

Joint experiments were organized or available during stratospheric flights of a photopolarimeter, referred to as RADIBAL (radiometer balloon). In May 1984, RADIBAL flew simultaneously with another balloonborne experiment conducted by the Institut d'Aeronomie Spatiale de Belgique (IASB), which provides multiwavelength vertical profiles of the aerosol scattering coefficient. At this time, the El Chichon layer was observable quite directly from mountain sites. A ground-based station set up at Pic du Midi allowed an extensive description of the aerosol optical properties. The IASB and the Pic du Midi observations are consistent with the aerosol properties derived from the RADIBAL measurement analysis.

[The Bulletin du cancer: the years before the First World War].

PubMed

Bernaudin, Jean-François

2013-12-01

Three years after its founding in 1909, the Association française pour l'étude du cancer is a major scientific society developing transdisciplinary debates particularly on innovative therapeutics in cancer, such as the developing use of radium. The Association at that time assembles together all the French medical elite. Reading the Bulletin offers a clear view of the brilliant monthly debates. First World War stopped the life of the Association for four years. After this break, the set up of dedicated centers for cancer treatment was responsible for a major turn in the Association's life.

The experience of bedaquiline implementation at a decentralised clinic in South Africa.

PubMed

Cariem, R; Cox, V; de Azevedo, V; Hughes, J; Mohr, E; Durán, L Triviño; Ndjeka, N; Furin, J

2016-09-01

Multidrug-resistant tuberculosis (MDR-TB) is a serious public health problem, but the new drugs bedaquiline (BDQ) and delamanid offer hope to improve outcomes and minimise toxicity. In Khayelitsha, South Africa, patients are routinely started on BDQ in the out-patient setting. This report from the field describes BDQ use in the out-patient setting at the Nolungile Clinic. The clinic staff overall report a positive experience using the drug. Challenges have been based largely on the logistics of drug supply and delivery. BDQ can be started successfully in the out-patient setting, and can be a positive experience for both patients and providers. La tuberculose multirésistante (TB-MDR) est un problème de santé publique grave, mais les nouveaux médicaments que sont la bédaquiline (BDQ) et le délamanide apportent un espoir d'améliorer les résultats tout en réduisant la toxicité. A Khayelitsha, Afrique du Sud, les patients démarrent leur traitement par BDQ en consultation externe en routine. Ce rapport du terrain décrit l'utilisation de la BDQ à la consultation externe du dispensaire Nolungile. Dans l'ensemble, le personnel du centre de santé exprime une expérience positive du médicament. Les défis ont surtout été liés à la logistique de l'approvisionnement et de la distribution du médicament. La BDQ peut être mise en route avec succès dans le cadre d'une consultation externe et peut constituer une expérience positive pour les patients et les prestataires de soins. La tuberculosis multirresistente (TB-MDR) representa un grave problema de salud pública, pero la utilización de nuevos medicamentos como la bedaquilina (BDQ) y el delamanid ofrece perspectivas de mejores desenlaces terapéuticos y disminución de la toxicidad asociada. En Khayelitsha, Suráfrica, se inicia de manera sistemática el tratamiento ambulatorio con BDQ. En el presente informe del terreno, se describe la utilización de BDQ en tratamiento antituberculoso ambulatorio en el centro de atención Nolungile. En general, los miembros del personal del centro refirieron una experiencia positiva con la administración del medicamento. Las dificultades surgieron en gran parte con respecto a aspectos logísticos del suministro y la administración del medicamento. Es posible iniciar un tratamiento eficaz con BDQ en condiciones ambulatorias, y represente una experiencia positiva para los pacientes y los profesionales de salud.

Beyond Schooling: Toward a Universalized System of Education.

ERIC Educational Resources Information Center

Kelly, Eugene W., Jr.

A comprehensive educational system should have enough internal identity and channels of communication so that educators in one setting can identify with those in other settings. The settings in which education takes place are not only schools and colleges, but also business, industry, and human services settings. The feasibility of establishing a…

Performance Prediction and Simulation of Gas Turbine Engine Operation (La presision des performances et la simulation du fonctionnement des turbomoteurs)

DTIC Science & Technology

2002-04-01

configuration associated with the HSCT program was analyzed in terms of inlet unstart and the effect of the regurgitated shock wave. Inlet start is a...heavily loaded take off or dog -fight phases of flight. Less critical issues, such as thrust loss during supersonic operations, may also appear. From the

Study on Cyber Security and Threat Evaluation in SCADA Systems

DTIC Science & Technology

2012-03-01

la sécurité de l’infrastructure essentielle du Canada. DRDC CSS CR 2012-06 vii • Les cadres de gestion des cybermenaces et des ...Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2012 DRDC CSS CR 2012-06 i Abstract …….. This...ii DRDC CSS CR 2012-06 Résumé …..... Le présent rapport fait la synthèse des résultats du projet PTSP 02-0347eSec

Helicopter Propulsion Systems

DTIC Science & Technology

1981-09-01

doessais do torborsotour MAKILA nous avons choisi trois easais gui ont pour objet die asiuier qoolguos ones des conditions oxposees prece6demisont et gui...46laLore one lin dv d~bit. Los ossais ao banc consistent A 6rablir cette loi poor 6n fonictionnement aui eol do sorte I cqutiie couvrei lensemble du...laisserons de c6t6 le facteur de ddcroissanco du prix en fonction du rang de s6rie ( loi de Wright) parce que, do par sa g6ndralit6, il n’est pas influenc6

The 1988 Antarctic ozone monitoring Nimbus-7 TOMS data atlas

NASA Technical Reports Server (NTRS)

Krueger, Arlin J.; Penn, Lanning M.; Larko, David E.; Doiron, Scott D.; Guimaraes, Patricia T.

1989-01-01

Because of the great environmental significance of ozone and to support continuing research at McMurdo, Syowa, and other Southern Hemisphere stations, the development of the 1988 ozone hole was monitored using data from the Nimbus-7 Total Ozone Mapping Spectrometer (TOMS) instrument, produced in near-real-time. This Atlas provides a complete set of daily polar orthographic projections of the TOMS total ozone measurements over the Southern Hemisphere for the period August 1 through November 17, 1988. Although total ozone in mini-holes briefly dropped below 150 DU in late August, the main ozone hole is seen to be much less pronounced than in 1987. Minimum values, observed in late September and early October 1988, were seldom less than 175 DU. Compared with the same period in 1987, when a pronounced ozone hole whose minimum value of 109 Dobson Units (DU) was the lowest total ozone ever observed, the 1988 ozone hole is displaced from the South Pole, opposing a persistent maximum with values consistently above 500 DU. Daily ozone values above selected Southern Hemisphere stations are presented, along with comparisons of the 1988 ozone distribution to that of other years.

Analyse des interactions energetiques entre un arena et son systeme de refrigeration

NASA Astrophysics Data System (ADS)

Seghouani, Lotfi

La presente these s'inscrit dans le cadre d'un projet strategique sur les arenas finance par le CRSNG (Conseil de Recherche en Sciences Naturelles et en Genie du Canada) qui a pour but principal le developpement d'un outil numerique capable d'estimer et d'optimiser la consommation d'energie dans les arenas et curlings. Notre travail s'inscrit comme une suite a un travail deja realise par DAOUD et coll. (2006, 2007) qui a developpe un modele 3D (AIM) en regime transitoire de l'arena Camilien Houde a Montreal et qui calcule les flux de chaleur a travers l'enveloppe du batiment ainsi que les distributions de temperatures et d'humidite durant une annee meteorologique typique. En particulier, il calcule les flux de chaleur a travers la couche de glace dus a la convection, la radiation et la condensation. Dans un premier temps nous avons developpe un modele de la structure sous la glace (BIM) qui tient compte de sa geometrie 3D, des differentes couches, de l'effet transitoire, des gains de chaleur du sol en dessous et autour de l'arena etudie ainsi que de la temperature d'entree de la saumure dans la dalle de beton. Par la suite le BIM a ete couple le AIM. Dans la deuxieme etape, nous avons developpe un modele du systeme de refrigeration (REFSYS) en regime quasi-permanent pour l'arena etudie sur la base d'une combinaison de relations thermodynamiques, de correlations de transfert de chaleur et de relations elaborees a partir de donnees disponibles dans le catalogue du manufacturier. Enfin le couplage final entre l'AIM +BIM et le REFSYS a ete effectue sous l'interface du logiciel TRNSYS. Plusieurs etudes parametriques on ete entreprises pour evaluer les effets du climat, de la temperature de la saumure, de l'epaisseur de la glace, etc. sur la consommation energetique de l'arena. Aussi, quelques strategies pour diminuer cette consommation ont ete etudiees. Le considerable potentiel de recuperation de chaleur au niveau des condenseurs qui peut reduire l'energie requise par le systeme de ventilation de l'arena a ete mis en evidence. Mots cles. Arena, Systeme de refrigeration, Consommation d'energie, Efficacite energetique, Conduction au sol, Performance annuelle.

Combined effects of depleted uranium and ionising radiation on zebrafish embryos.

PubMed

Ng, C Y P; Pereira, S; Cheng, S H; Adam-Guillermin, C; Garnier-Laplace, J; Yu, K N

2015-11-01

In the environment, living organisms are exposed to a mixture of stressors, and the combined effects are deemed as multiple stressor effects. In the present work, the authors studied the multiple stressor effect in embryos of the zebrafish (Danio rerio) from simultaneous exposure to alpha particles and depleted uranium (DU) through quantification of apoptotic signals at 24 h post-fertilisation (hpf) revealed by vital dye acridine orange staining. In each set of experiments, dechorionated zebrafish embryos were divided into 4 groups, each having 10 embryos: Group (C) in which the embryos did not receive any further treatment; Group (IU) in which the embryos received an alpha-particle dose of 0.44 mGy at 5 hpf and were then exposed to 100 µg l(-1) of DU from 5 to 6 hpf; Group (I) in which the embryos received an alpha-particle dose of 0.44 mGy at 5 hpf and Group (U) in which the dechorionated embryos were exposed to 100 µg l(-1) of DU from 5 to 6 hpf. The authors confirmed that an alpha-particle dose of 0.44 mGy and a DU exposure for 1 h separately led to hormetic and toxic effects assessed by counting apoptotic signals, respectively, in the zebrafish. Interestingly, the combined exposure led to an effect more toxic than that caused by the DU exposure alone, so effectively DU changed the beneficial effect (hormesis) brought about by alpha-particle irradiation into an apparently toxic effect. This could be explained in terms of the promotion of early death of cells predisposed to spontaneous transformation by the small alpha-particle dose (i.e. hormetic effect) and the postponement of cell death upon DU exposure. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice.

PubMed

Sawitzky, Mandy; Zeissler, Anja; Langhammer, Martina; Bielohuby, Maximilian; Stock, Peggy; Hammon, Harald M; Görs, Solvig; Metges, Cornelia C; Stoehr, Barbara J M; Bidlingmaier, Martin; Fromm-Dornieden, Carolin; Baumgartner, Bernhard G; Christ, Bruno; Brenig, Bertram; Binder, Gerhard; Metzger, Friedrich; Renne, Ulla; Hoeflich, Andreas

2012-01-01

We have investigated molecular mechanisms for muscle mass accretion in a non-inbred mouse model (DU6P mice) characterized by extreme muscle mass. This extreme muscle mass was developed during 138 generations of phenotype selection for high protein content. Due to the repeated trait selection a complex setting of different mechanisms was expected to be enriched during the selection experiment. In muscle from 29-week female DU6P mice we have identified robust increases of protein kinase B activation (AKT, Ser-473, up to 2-fold) if compared to 11- and 54-week DU6P mice or controls. While a number of accepted effectors of AKT activation, including IGF-I, IGF-II, insulin/IGF-receptor, myostatin or integrin-linked kinase (ILK), were not correlated with this increase, phosphatase and tensin homologue deleted on chromosome 10 (PTEN) was down-regulated in 29-week female DU6P mice. In addition, higher levels of PTEN phosphorylation were found identifying a second mechanism of PTEN inhibition. Inhibition of PTEN and activation of AKT correlated with specific activation of p70S6 kinase and ribosomal protein S6, reduced phosphorylation of eukaryotic initiation factor 2α (eIF2α) and higher rates of protein synthesis in 29-week female DU6P mice. On the other hand, AKT activation also translated into specific inactivation of glycogen synthase kinase 3ß (GSK3ß) and an increase of muscular glycogen. In muscles from 29-week female DU6P mice a significant increase of protein/DNA was identified, which was not due to a reduction of protein breakdown or to specific increases of translation initiation. Instead our data support the conclusion that a higher rate of protein translation is contributing to the higher muscle mass in mid-aged female DU6P mice. Our results further reveal coevolution of high protein and high glycogen content during the selection experiment and identify PTEN as gate keeper for muscle mass in mid-aged female DU6P mice.

Phenotype Selection Reveals Coevolution of Muscle Glycogen and Protein and PTEN as a Gate Keeper for the Accretion of Muscle Mass in Adult Female Mice

PubMed Central

Sawitzky, Mandy; Zeissler, Anja; Langhammer, Martina; Bielohuby, Maximilian; Stock, Peggy; Hammon, Harald M.; Görs, Solvig; Metges, Cornelia C.; Stoehr, Barbara J. M.; Bidlingmaier, Martin; Fromm-Dornieden, Carolin; Baumgartner, Bernhard G.; Christ, Bruno; Brenig, Bertram; Binder, Gerhard; Metzger, Friedrich; Renne, Ulla; Hoeflich, Andreas

2012-01-01

We have investigated molecular mechanisms for muscle mass accretion in a non-inbred mouse model (DU6P mice) characterized by extreme muscle mass. This extreme muscle mass was developed during 138 generations of phenotype selection for high protein content. Due to the repeated trait selection a complex setting of different mechanisms was expected to be enriched during the selection experiment. In muscle from 29-week female DU6P mice we have identified robust increases of protein kinase B activation (AKT, Ser-473, up to 2-fold) if compared to 11- and 54-week DU6P mice or controls. While a number of accepted effectors of AKT activation, including IGF-I, IGF-II, insulin/IGF-receptor, myostatin or integrin-linked kinase (ILK), were not correlated with this increase, phosphatase and tensin homologue deleted on chromosome 10 (PTEN) was down-regulated in 29-week female DU6P mice. In addition, higher levels of PTEN phosphorylation were found identifying a second mechanism of PTEN inhibition. Inhibition of PTEN and activation of AKT correlated with specific activation of p70S6 kinase and ribosomal protein S6, reduced phosphorylation of eukaryotic initiation factor 2α (eIF2α) and higher rates of protein synthesis in 29-week female DU6P mice. On the other hand, AKT activation also translated into specific inactivation of glycogen synthase kinase 3ß (GSK3ß) and an increase of muscular glycogen. In muscles from 29-week female DU6P mice a significant increase of protein/DNA was identified, which was not due to a reduction of protein breakdown or to specific increases of translation initiation. Instead our data support the conclusion that a higher rate of protein translation is contributing to the higher muscle mass in mid-aged female DU6P mice. Our results further reveal coevolution of high protein and high glycogen content during the selection experiment and identify PTEN as gate keeper for muscle mass in mid-aged female DU6P mice. PMID:22768110

Approximation auto-coherente a deux particules, pseudogap et supraconductivite dans le modele de Hubbard attractif

NASA Astrophysics Data System (ADS)

Allen, Steve

2000-10-01

Dans cette these nous presentons une nouvelle methode non perturbative pour le calcul des proprietes d'un systeme de fermions. Notre methode generalise l'approximation auto-coherente a deux particules proposee par Vilk et Tremblay pour le modele de Hubbard repulsif. Notre methode peut s'appliquer a l'etude du comportement pre-critique lorsque la symetrie du parametre d'ordre est suffisamment elevee. Nous appliquons la methode au probleme du pseudogap dans le modele de Hubbard attractif. Nos resultats montrent un excellent accord avec les donnees Monte Carlo pour de petits systemes. Nous observons que le regime ou apparait le pseudogap dans le poids spectral a une particule est un regime classique renormalise caracterise par une frequence caracteristique des fluctuations supraconductrices inferieure a la temperature. Une autre caracteristique est la faible densite de superfluide de cette phase demontrant que nous ne sommes pas en presence de paires preformees. Les resultats obtenus semblent montrer que la haute symetrie du parametre d'ordre et la bidimensionalite du systeme etudie elargissent le domaine de temperature pour lequel le regime pseudogap est observe. Nous argumentons que ce resultat est transposable aux supraconducteurs a haute temperature critique ou le pseudogap apparait a des' temperatures beaucoup plus grandes que la temperature critique. La forte symetrie dans ces systemes pourraient etre reliee a la theorie SO(5) de Zhang. En annexe, nous demontrons un resultat tout recent qui permettrait d'assurer l'auto-coherence entre les proprietes a une et a deux particules par l'ajout d'une dynamique au vertex irreductible. Cet ajout laisse entrevoir la possibilite d'etendre la methode au cas d'une forte interaction.

The Challenges of Mobilizing Workers on Gender Issues: Lessons from Two Studies on the Occupational Health of Teachers in Québec: Les défis de mobiliser les travailleur.ses sur la question du genre: Constats issus de deux recherches portant sur la santé au travail d'enseignant.es du Québec.

PubMed

Riel, Jessica; Major, Marie-Eve

2017-11-01

In partnership with the largest teachers' union confederation in Québec ( Centrale des syndicats du Québec), two qualitative research studies that integrate gender were conducted in the teaching community. These ergonomic studies advocated a participatory approach involving interviews and observations with high school teachers (thirty-five) and female teachers responsible for vocational training in trades with predominantly male clientele (twelve). The results revealed that gender influences work success by reducing the operational leeway available for female teachers to carry out their work and protect their health. In both studies, it was difficult to discuss these results with the teachers, especially with female teachers. Resistance, even denial, was present among high school teachers, while, in vocational training, resignation and a feeling of helplessness were observed. These reactions demonstrate that taking gender into account in prevention poses particular challenges that need to be addressed in order to promote equality between women and men in workplaces.

What is the burden of submicroscopic malaria in pregnancy in central India?

PubMed Central

Singh, Neeru; Bharti, Praveen K; Singh, Mrigendra P; Singh, Rajshree; Yeboah-Antwi, Kojo; Desai, Meghna; Udhayakumar, Venkatachalam; Muniyandi, Malaisamy; Hamer, Davidson H; Wylie, Blair J

2015-01-01

Background: Conventional microscopy underestimates the burden of malarial infection when compared with molecular diagnosis using polymerase chain reaction (PCR)-based methods. Lower density parasitemias serve as a reservoir for infection. We evaluated the prevalence of submicroscopic infections in an area of unstable malarial transmission in India and determined whether these infections negatively impacted maternal or fetal outcomes. Methods: This cross-sectional study (2007–2008) was undertaken in two districts of Chhattisgarh, recruiting women from both antenatal clinics (ANCs) and delivery units (DUs). For ANC/DU subjects, peripheral/placental blood, respectively, was obtained for conventional microscopy and collected onto filter paper for PCR analysis. Results: There were 3425 pregnant women, including 2477 ANC subjects and 948 DU subjects who had both microscopic and PCR samples available. Polymerase chain reaction detected significantly more Plasmodium infections than traditional light microscopy both from peripheral (3.4 vs 1.2%; OR 2.9, 95% confidence intervals (CIs) 1.9–4.5) and placental (4.2 vs 1.7%; OR 2.5, 95% CIs 1.4–4.8) blood samples. Submicroscopic infections were not associated with anemia or severe maternal anemia among ANC or DU participants and were not associated with low birth weight (LBW) among DU participants. In contrast, microscopically detected infections were associated with severe anemia and LBW. Conclusions: In this area of unstable malarial transmission from India, submicroscopic infections did not identify a set of pregnant women at increased risk for anemia or LBW. Until PCR techniques become much less expensive and available as a point of care test for the field setting, its use will be limited for malarial detection. PMID:25627878

Operational User Requirements and Priorities for a Soldier’s Integrated Headwear System (Priorites et Exigences Operationnelles du Casque Integre du Soldat)

DTIC Science & Technology

2006-11-21

considerations included thermal comfort in the heat, given the higher potential for heat casualties in hot, arid environments of ongoing and future conflicts...26 3.9.1 Thermal Comfort ...................................................................................................27...23 1. THERMAL COMFORT ................................................................................................. A-23 2. PHYSICAL COMFORT

Office Automation Pilot: A Paperless Approach at College of DuPage.

ERIC Educational Resources Information Center

Carlson, Bart

The pilot project described in this report was undertaken by the College of DuPage (CD) to increase the clerical efficiency of seven administrative offices through the installation of a computerized word processing and data transmission system. The first section of the report provides background information detailing: the history of computer…

Physicochemical characterization of Capstone depleted uranium aerosols IV: in vitro solubility analysis.

PubMed

Guilmette, Raymond A; Cheng, Yung Sung

2009-03-01

As part of the Capstone Depleted Uranium (DU) Aerosol Study, the solubility of selected aerosol samples was measured using an accepted in vitro dissolution test system. This static system was employed along with a SUF (synthetic ultrafiltrate) solvent, which is designed to mimic the physiological chemistry of extracellular fluid. Using sequentially obtained solvent samples, the dissolution behavior over a 46-d test period was evaluated by fitting the measurement data to two- or three-component negative exponential functions. These functions were then compared with Type M and S absorption taken from the International Commission on Radiological Protection Publication 66 Human Respiratory Tract Model. The results indicated that there was a substantial variability in solubility of the aerosols, which in part depended on the type of armor being impacted by the DU penetrator and the particle size fraction being tested. Although some trends were suggested, the variability noted leads to uncertainties in predicting the solubility of other DU-based aerosols. Nevertheless, these data provide a useful experimental basis for modeling the intake-dose relationships for inhaled DU aerosols arising from penetrator impact on armored vehicles.

A Proposal to the President to Establish a Year-Round Operation and an Annual Assignment System for Omega College, Beginning Summer 1974.

ERIC Educational Resources Information Center

Reda, Mario R.

The purpose of this paper is the presentation of a proposal for a year-round operation and an annual assignment system (YRO/AAS) to the administrative officers of the College of DuPage, Glen Ellyn, Illinois. The proposal is comprised of four chapters. The first chapter deals with the significance of the study in terms of the College of DuPage's…

"It Takes a Village to Raise a Child": The Role of Social Capital in Promoting Academic Success for African American Men at a Black College

ERIC Educational Resources Information Center

Palmer, Robert; Gasman, Marybeth

2008-01-01

Historically Black colleges and universities (HBCUs) were created to provide educational opportunities for African Americans when other higher education venues restricted their participation. HBCUs are credited with nurturing and producing leaders who embraced W. E. B. Du Bois's concept of the "Talented Tenth," and exhibiting fortitude in…

The ultimate disposition of depleted uranium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-12-01

Significant amounts of the depleted uranium (DU) created by past uranium enrichment activities have been sold, disposed of commercially, or utilized by defense programs. In recent years, however, the demand for DU has become quite small compared to quantities available, and within the US Department of Energy (DOE) there is concern for any risks and/or cost liabilities that might be associated with the ever-growing inventory of this material. As a result, Martin Marietta Energy Systems, Inc. (Energy Systems), was asked to review options and to develop a comprehensive plan for inventory management and the ultimate disposition of DU accumulated atmore » the gaseous diffusion plants (GDPs). An Energy Systems task team, under the chairmanship of T. R. Lemons, was formed in late 1989 to provide advice and guidance for this task. This report reviews options and recommends actions and objectives in the management of working inventories of partially depleted feed (PDF) materials and for the ultimate disposition of fully depleted uranium (FDU). Actions that should be considered are as follows. (1) Inspect UF{sub 6} cylinders on a semiannual basis. (2) Upgrade cylinder maintenance and storage yards. (3) Convert FDU to U{sub 3}O{sub 8} for long-term storage or disposal. This will include provisions for partial recovery of costs to offset those associated with DU inventory management and the ultimate disposal of FDU. Another recommendation is to drop the term tails'' in favor of depleted uranium'' or DU'' because the tails'' label implies that it is waste.'' 13 refs.« less

Knowledge, attitude, and experience of cervical cancer and screening among Sub-saharan African female students in a UK University.

PubMed

Ogbonna, Faith Sopuruchukwu

2017-01-01

Cervical cancer is one of the major diseases that affect women of child bearing age. Its main cause is the human papilloma virus; although, other associated factors have been evidenced to increase its risk. Pap-smear screening and vaccination which has been shown to be successful in reducing the incidence and prevalence of the disease in developed countries, has been neglected in developing countries due to lack of knowledge, misconceptions, and cultural beliefs. A cross-sectional study involving only female Sub-Saharan Africa (SSA) students in a UK university setting. One hundred and eighty-six (42%) African female students were recruited from the 442 SSA students attending one of the major Universities in the UK. Seventy-one (38.2%) of the students were aware of cervical screening, but only 20 (10.8%) reported having knowledge of cervical cancer. A small percentage of about 26.9% (50 Students) were already part of this screening program; although, 81 (43.5%) showed willingness to participate in future screening programs. More so, it was evident that student's perception was dependent on their experience of the disease (P = 000) just as their participation in screening program was dependent on their awareness level (P ≤ 0.01). Female African students from the SSA region have poor knowledge of the disease which influenced their attitude toward screening. More needs to be carried out to increase awareness and uptake of screening within the school environment as university setting provides a viable platform to promote healthy behavior. Résumé Contexte: Le cancer du col de l'utérus est l'une des principales maladies qui touchent les femmes en âge de procréer. Sa principale cause est le virus du papillome humain; Bien que, d'autres facteurs associés ont été mis en évidence pour augmenter son risque. Le dépistage du Pap et la vaccination, qui s'est avéré efficace pour réduire l'incidence et la prévalence de la maladie dans les pays développés, a été négligé dans les pays en développement en raison du manque de connaissances, d'idées fausses et de croyances culturelles. Matériel et Méthodes: Une étude transversale impliquant seulement des étudiantes d'Afrique subsaharienne (SSA) dans un université britannique. Résultats: Cent quatre-vingt-six (42%) étudiantes africaines ont été recrutées parmi les 442 étudiants SSA fréquentant l'une des plus grandes universités du Royaume-Uni. Soixante et onze (38,2%) des étudiants étaient au courant du dépistage du cancer du col, mais seulement 20 (10,8%) ont déclaré avoir une connaissance du cancer du col de l'utérus. Un faible pourcentage d'environ 26,9% (50 étudiants)Font déjà partie de ce programme de dépistage; 81 (43,5%) se sont montrés disposés à participer à de futurs programmes de dépistage. De plus, il était évident que la perception des étudiants dépendait de leur expérience de la maladie (P = 000), tout comme leur participation au programme de dépistage dépendait de leur niveau de sensibilisation (P ≤ 0,01). Les étudiantes africaines de la région de l'Afrique subsaharienne connaissent mal la maladie et ont influencé leur attitude envers le dépistage. Davantage de mesures doivent être prises pour accroître la sensibilisation et l'adoption du dépistage dans l'environnement scolaire, car le cadre universitaire constitue une plate-forme viable pour promouvoir un comportement sain.

Caracterisation thermique de modules de refroidissement pour la photovoltaique concentree

NASA Astrophysics Data System (ADS)

Collin, Louis-Michel

Pour rentabiliser la technologie des cellules solaires, une reduction du cout d'exploitation et de fabrication est necessaire. L'utilisation de materiaux photovoltaiques a un impact appreciable sur le prix final par quantite d'energie produite. Une technologie en developpement consiste a concentrer la lumiere sur les cellules solaires afin de reduire cette quantite de materiaux. Or, concentrer la lumiere augmente la temperature de la cellule et diminue ainsi son efficacite. Il faut donc assurer a la cellule un refroidissement efficace. La charge thermique a evacuer de la cellule passe au travers du recepteur, soit la composante soutenant physiquement la cellule. Le recepteur transmet le flux thermique de la cellule a un systeme de refroidissement. L'ensemble recepteur-systeme de refroidissement se nomme module de refroidissement. Habituellement, la surface du recepteur est plus grande que celle de la cellule. La chaleur se propage donc lateralement dans le recepteur au fur et a mesure qu'elle traverse le recepteur. Une telle propagation de la chaleur fournit une plus grande surface effective, reduisant la resistance thermique apparente des interfaces thermiques et du systeme de refroidissement en aval vers le module de refroidissement. Actuellement, aucune installation ni methode ne semble exister afin de caracteriser les performances thermiques des recepteurs. Ce projet traite d'une nouvelle technique de caracterisation pour definir la diffusion thermique du recepteur a l'interieur d'un module de refroidissement. Des indices de performance sont issus de resistances thermiques mesurees experimentalement sur les modules. Une plateforme de caracterisation est realisee afin de mesurer experimentalement les criteres de performance. Cette plateforme injecte un flux thermique controle sur une zone localisee de la surface superieure du recepteur. L'injection de chaleur remplace le flux thermique normalement fourni par la cellule. Un systeme de refroidissement est installe a la surface opposee du recepteur pour evacuer la chaleur injectee. Les resultats mettent egalement en evidence l'importance des interfaces thermiques et les avantages de diffuser la chaleur dans les couches metalliques avant de la conduire au travers des couches dielectriques du recepteur. Des recepteurs de multiples compositions ont ete caracterises, demontrant que les outils developpes peuvent definir la capacite de diffusion thermique. La repetabilite de la plateforme est evaluee par l'analyse de l'etendue des mesures repetees sur des echantillons selectionnes. La plateforme demontre une precision et reproductibilite de +/- 0.14 ° C/W. Ce travail fournit des outils pour la conception des recepteurs en proposant une mesure qui permet de comparer et d'evaluer l'impact thermique de ces recepteurs integres a uri module de refroidissement. Mots-cles : cellule solaire, photovoltaique, transfert de chaleur, concentration, resistances thermiques, plateforme de caracterisation, refroidissement

Therapeutic Effect of Duck Interferon-Alpha Against H5N1 Highly Pathogenic Avian Influenza Virus Infection in Peking Ducks.

PubMed

Gao, Pei; Xiang, Bin; Li, Yulian; Li, Yaling; Sun, Minhua; Kang, Yinfeng; Xie, Peng; Chen, Libin; Lin, Qiuyan; Liao, Ming; Ren, Tao

2018-04-01

The antiviral cytokine interferon-alpha (IFN-α) plays a critical role in the innate immune system. Previous studies have shown that recombinant chicken IFN-α inhibits avian influenza virus (AIV) replication in vivo; however, the antiviral effect of recombinant duck IFN-α (rDuIFN-α) on highly pathogenic AIV remains unknown. In this study, the duck IFN-α gene was cloned, expressed, and purified. The antiviral effects of the resulting rDuIFN-α were further evaluated in vitro and in vivo. Our results showed that rDuIFN-α inhibited the replication of vesicular stomatitis virus (VSV) and AIV in duck embryo fibroblasts in vitro, with antiviral activities against VSV and AIV of 2.1 × 10 5 and 4.1 × 10 5 U/mg, respectively. We next investigated the anti-H5N1 AIV effect of intramuscular injection of rDuIFN-α in vivo. rDuIFN-α reduced viral titers in the brains, lungs, and spleens of 2-day-old (2D) ducks compared with that in the virus-challenged control group, and pretreatment with rDuIFN-α reduced mortality from 60% to 10% in 2D ducks. Moreover, rDuIFN-α increased the expression of IFN-stimulated genes in the brains and spleens of 2D ducks. Our results demonstrate that rDuIFN-α blocks VSV and H5N1 influenza virus infection in vitro and exhibits antiviral effects against H5N1 influenza virus infection in 2D ducks.

Watershed Data Management (WDM) database for West Branch DuPage River streamflow simulation, DuPage County, Illinois, January 1, 2007, through September 30, 2013

USGS Publications Warehouse

Bera, Maitreyee

2017-10-16

The U.S. Geological Survey (USGS), in cooperation with the DuPage County Stormwater Management Department, maintains a database of hourly meteorological and hydrologic data for use in a near real-time streamflow simulation system. This system is used in the management and operation of reservoirs and other flood-control structures in the West Branch DuPage River watershed in DuPage County, Illinois. The majority of the precipitation data are collected from a tipping-bucket rain-gage network located in and near DuPage County. The other meteorological data (air temperature, dewpoint temperature, wind speed, and solar radiation) are collected at Argonne National Laboratory in Argonne, Ill. Potential evapotranspiration is computed from the meteorological data using the computer program LXPET (Lamoreux Potential Evapotranspiration). The hydrologic data (water-surface elevation [stage] and discharge) are collected at U.S.Geological Survey streamflow-gaging stations in and around DuPage County. These data are stored in a Watershed Data Management (WDM) database.This report describes a version of the WDM database that is quality-assured and quality-controlled annually to ensure datasets are complete and accurate. This database is named WBDR13.WDM. It contains data from January 1, 2007, through September 30, 2013. Each precipitation dataset may have time periods of inaccurate data. This report describes the methods used to estimate the data for the periods of missing, erroneous, or snowfall-affected data and thereby improve the accuracy of these data. The other meteorological datasets are described in detail in Over and others (2010), and the hydrologic datasets in the database are fully described in the online USGS annual water data reports for Illinois (U.S. Geological Survey, 2016) and, therefore, are described in less detail than the precipitation datasets in this report.

A Comparative Study of the Literature on the Dissemination and Utilization of Scientific Knowledge.

ERIC Educational Resources Information Center

Havelock, Ronald G.; And Others

This report provides a framework for understanding the processes of innovation, dissemination, and knowledge utilization (D&U) and it reviews the relevant literature in education and other fields of practice within this framework. D&U is viewed as a transfer of messages by various media between resource systems and users. Major sections analyze…

Interview DG Prof.B.Gregory by E.Schaerlig

ScienceCinema

None

2017-12-09

L'interview en français de 21 min. donné en février concerne le démarrage du "SuperCern" et est accompagné par moments de musique- 3 min. de pause, ensuite autre exposé (debut manque) en anglais parlant du CDC programming system avec questions

The Dutch Linguistic Intraoperative Protocol: a valid linguistic approach to awake brain surgery.

PubMed

De Witte, E; Satoer, D; Robert, E; Colle, H; Verheyen, S; Visch-Brink, E; Mariën, P

2015-01-01

Intraoperative direct electrical stimulation (DES) is increasingly used in patients operated on for tumours in eloquent areas. Although a positive impact of DES on postoperative linguistic outcome is generally advocated, information about the neurolinguistic methods applied in awake surgery is scarce. We developed for the first time a standardised Dutch linguistic test battery (measuring phonology, semantics, syntax) to reliably identify the critical language zones in detail. A normative study was carried out in a control group of 250 native Dutch-speaking healthy adults. In addition, the clinical application of the Dutch Linguistic Intraoperative Protocol (DuLIP) was demonstrated by means of anatomo-functional models and five case studies. A set of DuLIP tests was selected for each patient depending on the tumour location and degree of linguistic impairment. DuLIP is a valid test battery for pre-, intraoperative and postoperative language testing and facilitates intraoperative mapping of eloquent language regions that are variably located. Copyright © 2014 Elsevier Inc. All rights reserved.

Aerosol sampling system for collection of Capstone depleted uranium particles in a high-energy environment.

PubMed

Holmes, Thomas D; Guilmette, Raymond A; Cheng, Yung Sung; Parkhurst, Mary Ann; Hoover, Mark D

2009-03-01

The Capstone Depleted Uranium (DU) Aerosol Study was undertaken to obtain aerosol samples resulting from a large-caliber DU penetrator striking an Abrams or Bradley test vehicle. The sampling strategy was designed to (1) optimize the performance of the samplers and maintain their integrity in the extreme environment created during perforation of an armored vehicle by a DU penetrator, (2) collect aerosols as a function of time post perforation, and (3) obtain size-classified samples for analysis of chemical composition, particle morphology, and solubility in lung fluid. This paper describes the experimental setup and sampling methodologies used to achieve these objectives. Custom-designed arrays of sampling heads were secured to the inside of the target in locations approximating the breathing zones of the crew locations in the test vehicles. Each array was designed to support nine filter cassettes and nine cascade impactors mounted with quick-disconnect fittings. Shielding and sampler placement strategies were used to minimize sampler loss caused by the penetrator impact and the resulting fragments of eroded penetrator and perforated armor. A cyclone train was used to collect larger quantities of DU aerosol for measurement of chemical composition and solubility. A moving filter sample was used to obtain semicontinuous samples for DU concentration determination. Control for the air samplers was provided by five remotely located valve control and pressure monitoring units located inside and around the test vehicle. These units were connected to a computer interface chassis and controlled using a customized LabVIEW engineering computer control program. The aerosol sampling arrays and control systems for the Capstone study provided the needed aerosol samples for physicochemical analysis, and the resultant data were used for risk assessment of exposure to DU aerosol.

Fiches Pratiques: Mots...a croiser; Profitons du cinema; Le discours rapporte; Cent ans (Practical Ideas: Words...to Cross; Let's Take Advantage of the Movies; Relating Others' Discourse; One Hundred Years).

ERIC Educational Resources Information Center

Vever, Daniel; And Others

1991-01-01

Four class activities for French language instruction are described, including a crossword puzzle exercise emphasizing French culture, use of films for developing a variety of language skills, techniques for helping students discuss others' ideas, and an exercise promoting discussion through photographs of older adults engaged in various…

Effect of polarized radiative transfer on the Hanle magnetic field determination in prominences: Analysis of hydrogen H alpha line observations at Pic-du-Midi

NASA Technical Reports Server (NTRS)

Bommier, V.; Deglinnocenti, E. L.; Leroy, J. L.; Sahal-Brechot, S.

1985-01-01

The linear polarization of the Hydrogen H alpha line of prominences has been computed, taking into account the effect of a magnetic field (Hanle effect), of the radiative transfer in the prominence, and of the depolarization due to collisions with the surrounding electrons and protons. The corresponding formalisms are developed in a forthcoming series of papers. In this paper, the main features of the computation method are summarized. The results of computation have been used for interpretation in terms of magnetic field vector measurements from H alpha polarimetric observations in prominences performed at Pic-du-Midi coronagraph-polarimeter. Simultaneous observations in one optically thin line (He I D(3)) and one optically thick line (H alpha) give an opportunity for solving the ambiguity on the field vector determination.

Estimates of groundwater age from till and carbonate bedrock hydrogeologic units at Jefferson Proving Ground, Southeastern Indiana, 2007-08

USGS Publications Warehouse

Buszka, Paul M.; Lampe, David C.; Egler, Amanda L.

2010-01-01

During 2007-08, the U.S. Geological Survey, in cooperation with the U.S. Department of the Army, conducted a study to evaluate the relative age of groundwater in Pre-Wisconsinan till and underlying shallow and deep carbonate bedrock units in and near an area at Jefferson Proving Ground (JPG), southeastern Indiana, which was used during 1984-94 to test fire depleted uranium (DU) penetrators. The shallow carbonate unit includes about the upper 40 feet of bedrock below the bedrock-till surface; the deeper carbonate unit includes wells completed at greater depth. Samples collected during April 2008 from 15 wells were analyzed for field water-quality parameters, dissolved gases, tritium, and chlorofluorocarbon (CFC) compounds; samples from 14 additional wells were analyzed for tritium only. Water-level gradients in the Pre-Wisconsinan till and the shallow carbonate unit were from topographically higher areas toward Big Creek and Middle Fork Creek, and their tributaries. Vertical gradients were strongly downward from the shallow carbonate unit toward the deep carbonate unit at 3 of 4 paired wells where water levels recovered after development; indicating the general lack of flow between the two units. The lack of post development recovery of water levels at 4 other wells in the deep carbonate unit indicate that parts of that unit have no appreciable permeability. CFC and tritium-based age dates of Pre-Wisconsinan till groundwater are consistent with infiltration of younger (typically post-1960 age) recharge that 'mixes' with older recharge from less permeable or less interconnected strata. Part of the recharge to three till wells dated from the early to mid-1980s (JPG-DU-03O, JPG-DU-09O, and JPG-DU-10O). Age dates of young recharge in water from two till wells predated 1980 (JPG-DU-04O and JPG-DU-06O). Tritium-based age dates of water from seven other till wells indicated post-1972 age recharge. Most wells in the Pre-Wisconsinan till have the potential to produce groundwater that partially was recharged during or after DU penetrator testing; their water quality can indicate the presence of DU-related contaminants. The shallow carbonate unit near Big Creek is a karst flow system that may be recharged in part from areas with smaller thicknesses of overlying till or through more permeable parts of the till. This is indicated by CFC- and tritium-based piston-flow (non-mixing) model age dates of early-1980s for water from JPG-DU-02I, similar tritium-based ages of water produced from nearby wells MW-5 and MW-11, and cave development along the creek. The CFC and tritium-based age dates indicate that water samples from JPG-DU-01I and JPG-DU-03I were best described as mixtures of post-1984 modern recharge and submodern (1953 or older) recharge. These five wells produced groundwater that was recharged, at least partially, during or after DU-penetrator testing and are within or downgradient from the DU Impact Area with respect to groundwater flow directions inferred from water-level contours. Wells with groundwater age dates that are near to or after the onset (1984) of DU penetrator testing and that have a plausible connection to a contaminant source can be used to indicate the presence or absence of contaminants from DU penetrator or DU-related corrosion products in groundwater. Groundwater-age dates indicate that the ages of recharge sampled from shallow carbonate unit wells JPG-DU-04I, JPG-DU-05I, JPG-DU-06I, JPG-DU-09I, and JPG-DU-10D in easternmost (upgradient) and southernmost wells in the shallow carbonate unit are submodern (1953 or older) and predate the DU testing by at least 30 or more years. Water-quality data from these five wells are not likely to represent effects from DU-projectile testing or corrosion for years. Well JPG-DU-09D in the deep carbonate unit produced groundwater samples with a submodern (1953 or older) age date. The slow recovery of water levels in most wells in the deep carbonate unit is consis

Academic Calendar Task Force Report to the President.

ERIC Educational Resources Information Center

College of DuPage, Glen Ellyn, IL.

This report presents the findings of a study done by a college-wide task force at the College of DuPage (Illinois) on academic calendar formats in an effort to determine whether to retain the quarter system or convert to another calendar. A brief introduction gives the background to the issue at DuPage. A section on procedures explains that the…

Le modele de Hubbard bidimensionnel a faible couplage: Thermodynamique et phenomenes critiques

NASA Astrophysics Data System (ADS)

Roy, Sebastien

Une etude systematique du modele de Hubbard en deux dimensions a faible couplage a l'aide de la theorie Auto-Coherente a Deux Particules (ACDP) dans le diagramme temperature-dopage-interaction-sauts permet de mettre en evidence l'influence des fluctuations magnetiques sur les proprietes thermodynamiques du systeme electronique sur reseau. Le regime classique renormalise a temperature finie pres du dopage nul est marque par la grandeur de la longueur de correlation de spin comparee a la longueur thermique de de Broglie et est caracterisee par un accroissement drastique de la longueur de correlation de spin. Cette croissance exponentielle a dopage nul marque la presence d'un pic de chaleur specifique en fonction de la temperature a basse temperature. Une temperature de crossover est alors associee a la temperature a laquelle la longueur de correlation de spin est egale a la longueur thermique de de Broglie. C'est a cette temperature caracteristique, ou est observee l'ouverture du pseudogap dans le poids spectral, que se situe le maximum du pic de chaleur specifique. La presence de ce pic a des consequences sur l'evolution du potentiel chimique avec le dopage lorsque l'uniformite thermodynamique est respectee. Les contraintes imposees par les lois de la thermodynamique font en sorte que l'evolution du potentiel chimique avec le dopage est non triviale. On demontre entre autres que le potentiel chimique est proportionnel a la double occupation qui est reliee au moment local. Par ailleurs, une derivation de la fonction de mise a l'echelle de la susceptibilite de spin a frequence nulle au voisinage d'un point critique marque sans equivoque la presence d'un point critique quantique en dopage pour une valeur donnee de l'interaction. Ce point critique, associe a une transition de phase magnetique en fonction du dopage a temperature nulle, induit un comportement non trivial sur les proprietes physiques du systeme a temperature finie. L'approche quantitative ACDP permet de calculer une echelle de temperature concrete pour laquelle ce point critique a des repercussions. Dans le regime critique, la longueur de correlation enregistre plutot une dependance en 1T Finalement, une synthese de ces resultats permet d'aborder une mise en application pratique de ces methodes d'analyse pour les supraconducteurs a haute temperature critique dopes aux electrons tels que le Nd2--xCe xCuO4+/-delta. Une comparaison entre les resultats theoriques et les mesures experimentales pour ce materiau est effectuee.

Excrétion rénale des ions divalents après homotransplantation rénale

PubMed Central

Cartier, F.; Popovtzer, M. M.; Robinette, J.; Pinggera, W. F.; Halgrimson, C. G.; Starzl, T. E.

2010-01-01

RÉSUMÉ L’élimination rénale des ions divalents, celle du Na et du K, ont été étudiées de façon comparative dans les suites immédiates de l’homotransplantation rénale chez 6 patients. Durant la période initiale polyurique (> 3ml/mn), le taux d’excrétion du Ca filtré (Cca/Ccr), du Mg, du P, du Na et du K, est élevé et il existe une corrélation étroite et quasi constante entre l’élimination du Ca, du Mg et du Na ; la corrélation n’est pas constante entre l’élimination du Na et du K, du Mg et du K. Pendant les deux jours suivants, le taux d’excrétion diminue, sauf pour le P ; il existe encore une corrélation entre l’excrétion du Ca, du Mg et du Na, non entre celle du Na et du K, du Mg et du K. L’excrétion du Ca l’emporte sur celle du Na au cours de la première période, non au cours de la seconde. A la lumière de ces données, on envisage l’intervention possible de divers facteurs, tels l’inflation hydrosique et l’hyperazotémie préalables, l’ischémie rénale contemporaine de la transplantation, les effets de la dénervation rénale, du traitement cortisonique, de l’hyperparathyroïdie et ceux des modifications circulatoires rénales. PMID:4574592

Drone-borne GPR design: Propagation issues

NASA Astrophysics Data System (ADS)

Chandra, Madhu; Tanzi, Tullio Joseph

2018-01-01

In this paper, we shall address the electromagnetic wave propagation issues that are critical to determining the feasibility of a drone-borne ground-penetrating radar sensor for humanitarian applications, particularly in the context of disaster management. Frequency- and polarization-dependent scattering, attenuation and dispersion of radar signals penetrating into the sub-surface region will determine the applicability of a drone-mounted radar sensor capable of registering radar echoes for observing and monitoring sub-surface features. The functionality of the radar will thus be assessed depending on key radar parameters that include the central radar frequency, the modulation depth, and the mode of radar operation (pulsed FM, FM-CW), the antenna type, the available power-budget. In the analysis to be presented, the radar equation, together with the aforementioned propagation effects, will be used to simulate the signal strength of radar echoes under different conditions arising from the chosen key-radar parameters and the assumed physical properties of the sub-surface earth medium. The analysis to be presented will indicate whether or not the drone-borne ground-penetrating radar is a feasible system and if it could be constructed with the technologies available today. Taking into account the strict constraints involved to design drone applications for Public Protection and Disaster Relief (PPDR), the ideas developed hereafter are both prospective and exploratory. The objective is to see if a solution can be found in the near future. xml:lang="fr" Dans l'analyse présentée, l'équation radar, ainsi que les effets de propagation susmentionnés, serviront à simuler la puissance du signal des échos radar sous différentes conditions découlant des paramètres clés choisis et les propriétés physiques du milieu sous la surface. L'étude a pour objectif de démontrer si le système est réalisable et s'il peut être construit avec les technologies disponibles aujourd'hui. En raison du contexte très contraignant des applications pour la protection du public et secours en cas de catastrophe, les idées ici développées ont un caractère tout à la fois prospectif et exploratoire, l'objectif étant d'examiner si, dans un avenir proche, une solution se dessinerait.

[Effects of overexpression of miR-17-92 gene cluster on the biological characteristics of prostate cancer cells and its mechanism].

PubMed

Zhou, P; Ma, L; Zhou, J; Xu, J J; Liu, F; Guo, F

2017-05-23

Objective: To explore the effect and mechanism of over-expression of miR-17-92 gene cluster on the biological characteristics of prostate cancer cells. Methods: DU145 cells were transfected with miR-17-92 gene expression plasmid and clones with stable ectopic miR-17-92 overexpression were established. The cell viabilities of DU145-17-92 and DU145-control cells were monitored by xCELLigence system. Cell proliferation and apoptosis were analyzed by Ki-67 and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Cell cycle was detected by flow cytometry. Expression levels of proteins involved in apoptosis and Akt pathway were determined by western blotting. Results: xCELLigence RTCA array data showed that the growth rate of DU145-17-92 cells was significantly higher than that of DU145-control cells after 24 h of seeding ( P <0.01). The Ki-67-positive rates of the DU145-control group at 24, 48 and 72 hours were (56.57±1.68)%, (85.48±0.26)% and (90.85±2.08)%, respectively. While the Ki-67 positive rates of the DU145-17-92 group at the desired time points were (73.64±0.68)%, (93.43±1.23)% and (97.36±0.86)%, respectively, with a statistically significant difference at 24 hours ( P <0.01). The percentages of apoptotic cells of the DU145-control group at 24, 48 and 72 hours were (6.76±0.09)%, (14.51±0.86)% and (20.73±1.64)%, respectively, while the apoptotic percentages of the DU145-17-92 group were (1.86±0.15)%, (7.90±0.40)% and (4.92±0.48)%, respectively. The percentages of apoptotic cells of the DU145-control group at different time were significantly higher than those of DU145-17-92 group ( P <0.01 for all). The result of western blotting showed that the protein expression levels of Bcl-2 interacting mediator of cell death (BIM) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in DU145-control cells were 0.83±0.00 and 0.91±0.00, respectively, significantly higher than 0.16±0.00 and 0.13±0.00 of DU145-17-92 cells (both P <0.01). Overexpression of miR17-92 induced the phosphorylation of protein kinase B (Akt) at Ser473 while no appreciable effect on the phosphorylation of Akt at Thr308. The phosphorylated level of extracellular regulated protein kinases (ERK) in DU145-control cells was 0.21±0.01, significantly lower than 0.72±0.01 of DU145-17-92 cells ( P <0.01). Conclusions: Overexpression of miR-17-92 gene plays a pivotal role in growth, proliferation, apoptosis and cell cycle of DU145 cells through down-regulation of apoptotic protein BIM and tumor suppressor PTEN and activation of Akt and ERK signaling pathway.

Collective Political Violence in Easton’s Political Systems Model (La Violence Politique Collective dans le Modele de Systeme Politique d’Easton)

DTIC Science & Technology

2011-09-01

opérationnelle) [ novembre 2010], note publiée pendant la première phase du projet, soit l’élaboration conceptuelle du programme de recherche. DRDC Toronto...Kirkpatrick, D. & Sanger, D. (2011). A Tunisian-Egyptian link that shook Arab history. The New York Times, 13 February 2011. Martin, J. (1986). The...body of abstract and indexing annotation must be entered when the overall document is classified) 13 . ABSTRACT (A brief and factual summary of the

Reading the Legal World: Literacy and Justice in Canada. Report of the Canadian Bar Association Task Force on Legal Literacy = Lire les lois: Justice et alphabetisation au Canada. Rapport du Groupe de travail de l'Association du Barreau canadien sur l'alphabetisation.

ERIC Educational Resources Information Center

Canadian Bar Association, Ottawa (Ontario).

A Canadian Bar Association Task Force on Legal Literacy explored the relationship between literacy and access to the legal system. A literature review revealed that little attention had been directed to literacy and use of the legal system. Three important findings emerged from 24 focus groups of current and former adult learners: virtually all…

Agricultural Spraying

NASA Technical Reports Server (NTRS)

1986-01-01

AGDISP, a computer code written for Langley by Continuum Dynamics, Inc., aids crop dusting airplanes in targeting pesticides. The code is commercially available and can be run on a personal computer by an inexperienced operator. Called SWA+H, it is used by the Forest Service, FAA, DuPont, etc. DuPont uses the code to "test" equipment on the computer using a laser system to measure particle characteristics of various spray compounds.

[Role of health volunteers for patients with amyotrophic lateral sclerosis and their family].

PubMed

Bardet, L

2006-06-01

In ALS Centers, the patient receives coordinated care from Health Volunteers and the medical team including specialized physicians, therapists and social workers. There are two types of volunteers: those who assist the patient in hospital, the Medical Volunteers (MV), and those who make home visits, the Home Volunteers (HV). Both are recruited and trained by the ARS and have a single motivation: help the patient's; they are emotionally and morally fully qualified to accomplish their task in accordance with the rules that have been set by the Association. The ALS patient is seen for the first time by the Medical Volunteer at the ALS Center, immediately after his or her disease has been diagnosed by the clinic's director. The MV takes the initiative for the dialogue, which he/she leads gently and tactfully. The discussion is aimed at gathering useful information to be put in the document: "Connaissance du malade" (knowledge of the patient), working out the patient's primary concerns and assessing the carer's commitment, in a friendly atmosphere. Finally the volunteer gives the guidebook, "Livret d'accueil" to the patient. After the conversation, the MV decides which confidential pieces of information are to be passed on to the medical staff with a view to sorting out problems; information is then set the HV who will provide follow up care for this patient. Long-term care management of ALS patients is achieved through three regular monthly appointments at the ALS Center. With the help of the document "Connaissance du malade" the MV keeps better in touch with the patient using the feedback from the HV about what has been going on in the interval between the two visits to the ALS Center. This collaboration enables appropriate follow up care for the patients with clearly-defined objectives: dealing with the patient's anxiety, understanding his/her position at the present time, his/her daily routine and needs, comforting, checking compliance with treatment, counselling and supporting the family, answering delicate questions. Thus, the Health Volunteer's mission contributes meaningfully to medical treatment. This approach likely helps the person affected by ALS to regain the initially deteriorated sense of belonging to the social body.

Effects of tumour necrosis factor α upon the metabolism of the endocannabinoid anandamide in prostate cancer cells.

PubMed

Karlsson, Jessica; Gouveia-Figueira, Sandra; Alhouayek, Mireille; Fowler, Christopher J

2017-01-01

Tumour necrosis factor α (TNFα) is involved in the pathogenesis of prostate cancer, a disease where disturbances in the endocannabinoid system are seen. In the present study we have investigated whether treatment of DU145 human prostate cancer cells affects anandamide (AEA) catabolic pathways. Additionally, we have investigated whether cyclooxygenase-2 (COX-2) can regulate the uptake of AEA into cells. Levels of AEA synthetic and catabolic enzymes were determined by qPCR. AEA uptake and hydrolysis in DU145 and RAW264.7 macrophage cells were assayed using AEA labeled in the arachidonic and ethanolamine portions of the molecule, respectively. Levels of AEA, related N-acylethanolamines (NAEs), prostaglandins (PG) and PG-ethanolamines (PG-EA) in DU145 cells and medium were quantitated by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis. TNFα treatment of DU145 cells increased mRNA levels of PTSG2 (gene of COX-2) and decreased the mRNA of the AEA synthetic enzyme N-acyl-phosphatidylethanolamine selective phospholipase D. mRNA levels of the AEA hydrolytic enzymes fatty acid amide hydrolase (FAAH) and N-acylethanolamine-hydrolyzing acid amidase were not changed. AEA uptake in both DU145 and RAW264.7 cells was inhibited by FAAH inhibition, but not by COX-2 inhibition, even in RAW264.7 cells where the expression of this enzyme had greatly been induced by lipopolysaccharide + interferon γ treatment. AEA and related NAEs were detected in DU145 cells, but PGs and PGE2-EA were only detected when the cells had been preincubated with 100 nM AEA. The data demonstrate that in DU145 cells, TNFα treatment changes the relative expression of the enzymes involved in the hydrolytic and oxygenation catabolic pathways for AEA. In RAW264.7 cells, COX-2, in contrast to FAAH, does not regulate the cellular accumulation of AEA. Further studies are necessary to determine the extent to which inflammatory mediators are involved in the abnormal endocannabinoid signalling system in prostate cancer.

Etude thermo-hydraulique de l'ecoulement du moderateur dans le reacteur CANDU-6

NASA Astrophysics Data System (ADS)

Mehdi Zadeh, Foad

Etant donne la taille (6,0 m x 7,6 m) ainsi que le domaine multiplement connexe qui caracterisent la cuve des reacteurs CANDU-6 (380 canaux dans la cuve), la physique qui gouverne le comportement du fluide moderateur est encore mal connue de nos jours. L'echantillonnage de donnees dans un reacteur en fonction necessite d'apporter des changements a la configuration de la cuve du reacteur afin d'y inserer des sondes. De plus, la presence d'une zone intense de radiations empeche l'utilisation des capteurs courants d'echantillonnage. En consequence, l'ecoulement du moderateur doit necessairement etre etudie a l'aide d'un modele experimental ou d'un modele numerique. Pour ce qui est du modele experimental, la fabrication et la mise en fonction de telles installations coutent tres cher. De plus, les parametres de la mise a l'echelle du systeme pour fabriquer un modele experimental a l'echelle reduite sont en contradiction. En consequence, la modelisation numerique reste une alternative importante. Actuellement, l'industrie nucleaire utilise une approche numerique, dite de milieu poreux, qui approxime le domaine par un milieu continu ou le reseau des tubes est remplace par des resistances hydrauliques distribuees. Ce modele est capable de decrire les phenomenes macroscopiques de l'ecoulement, mais ne tient pas compte des effets locaux ayant un impact sur l'ecoulement global, tel que les distributions de temperatures et de vitesses a proximite des tubes ainsi que des instabilites hydrodynamiques. Dans le contexte de la surete nucleaire, on s'interesse aux effets locaux autour des tubes de calandre. En effet, des simulations faites par cette approche predisent que l'ecoulement peut prendre plusieurs configurations hydrodynamiques dont, pour certaines, l'ecoulement montre un comportement asymetrique au sein de la cuve. Ceci peut provoquer une ebullition du moderateur sur la paroi des canaux. Dans de telles conditions, le coefficient de reactivite peut varier de maniere importante, se traduisant par l'accroissement de la puissance du reacteur. Ceci peut avoir des consequences majeures pour la surete nucleaire. Une modelisation CFD (Computational Fluid Dynamics) detaillee tenant compte des effets locaux s'avere donc necessaire. Le but de ce travail de recherche est de modeliser le comportement complexe de l'ecoulement du moderateur au sein de la cuve d'un reacteur nucleaire CANDU-6, notamment a proximite des tubes de calandre. Ces simulations servent a identifier les configurations possibles de l'ecoulement dans la calandre. Cette etude consiste ainsi a formuler des bases theoriques a l'origine des instabilites macroscopiques du moderateur, c.-a-d. des mouvements asymetriques qui peuvent provoquer l'ebullition du moderateur. Le defi du projet est de determiner l'impact de ces configurations de l'ecoulement sur la reactivite du reacteur CANDU-6.

The Influence of Blade Profile and Slots on the Performance of a Centrifugal Impeller (Influence du Profil de Pales et Fentes sur la Performance d’un Ventilateur Centrifuge),

DTIC Science & Technology

1980-01-01

instability at low flows was investigated. The major cause was found to be flow detachment from the impeller vanes . ] Slotted blades were found to be...Characteristics (70 RPM), Variant (D- Aerofoil Blades , Sets VB1, 2 & 3...12 7 Pressure Rise - Flow Characteristics (70 RPM), Variant () - Slotted Aerofoil Blades , Sets VB1, 2 & 3

Antithrombotic effects of factor Xa inhibition with DU-176b: Phase-I study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamber.

PubMed

Zafar, Mohammad Urooj; Vorchheimer, David A; Gaztanaga, Juan; Velez, Mauricio; Yadegar, Daniel; Moreno, Pedro R; Kunitada, Satoshi; Pagan, Juan; Fuster, Valentin; Badimon, Juan J

2007-10-01

Direct and specific inhibition of factor Xa is an emerging therapeutic strategy for atherothrombotic disease. Parenteral factor Xa inhibitors promise efficacy comparable to standard therapies, which could be extended to ambulatory patients with oral agents. We evaluated the antithrombotic effect of the oral, direct factor Xa inhibitor DU-176b in a phase-I study. Healthy subjects (n = 12) received a single, 60 mg dose of DU-176b. Antithrombotic effects were assessed by comparing ex-vivo thrombus formation at 1.5, 5, and 12 hours post-dose versus baseline, along with factor Xa activity, thrombin generation and clotting parameters. Under venous flow after 1.5 and 5 hours, the thrombus was 28% and 21% smaller versus baseline, respectively (p < 0.05). Under arterial condition, the reduction was 26% and 17% (p < 0.05). Thrombin generation decreased by 28% at 1.5 hours and 10% at 5 hours. Changes in PT and INR correlated well with plasma drug concentrations (R2 = 0.79 and 0.78). Direct and specific inhibition of factor Xa by DU-176b significantly reduced ex-vivo thrombus formation at both venous and arterial rheologies, up to 5 hours post-dose. The effects mirrored changes in clotting parameters, suggesting their potential usefulness for monitoring in a clinical setting.

Developpement d'un catalyseur nickel-alumine efficace pour le reformage de diesel a la vapeur d'eau et etude du systeme reactionnel

NASA Astrophysics Data System (ADS)

Fauteux-Lefebvre, Clemence

Le developpement de sources d'energie alternatives fiables et efficaces est aujourd'hui une necessite. L' interet dans le reformage d'hydrocarbures liquides est ainsi croissant puisqu'il s'agit d'une voie pour l'alimentation des piles a combustible. Les piles a combustible ont une efficacite pour la conversion d'energie en electricite plus grande que celle des moteurs a combustion et font ainsi partie de la recherche de solution en efficacite energetique. Ces piles consomment de l'hydrogene comme combustible pour produire de l'electricite, d'ou l'interet pour le reformage. En effet, cette reaction permet de produire de l'hydrogene et du monoxyde de carbone (un autre combustible des piles a combustible a electrolyte solide) a partir d'hydrocarbure liquide, notamment le diesel. Les piles pourraient donc etre integrees avec une unite de reformage leur fournissant directement le combustible necessaire a partir de diesel. Dans ce projet de recherche, un nouveau catalyseur de nickel sous forme de spinelle nickel-alumine (spinelle NiAl2O4 sur support d'alumine et de zircone stabilisee avec yttria) a ete developpe et teste en laboratoire pour du reformage de propane, d'hydrocarbures liquides et de diesel, a la vapeur d'eau. Par ailleurs, une methode d'ajout des reactifs novatrice a ete utilisee afin de diminuer la pyrolyse precedant le reformage, en utilisant une emulsion. Les resultats de reformage d'hydrocarbures purs ont montre des concentrations tres pres de l'equilibre thermodynamique et une activite constante sans desactivation du catalyseur ni formation de carbone, et ce avec des ratios H2O/C de moins de 2.5 et des temperatures d'operation variant entre 630 °C et 750 °C. Lors de tests effectues en utilisant du diesel fossile, a 705°C, avec un debit volumique des reactifs de plus de 50 000 cm3gcat-1h-1 et un ratio H2O/C de moins de 2.5, l'activite a ete maintenue pendant plus de 15 heures, malgre une operation en cycles. L'analyse du catalyseur apres cette utilisation n'a montre aucun carbone significatif sur la surface.- En comparaison, un catalyseur de nickel metallique sur support d'Al2O3 et YSZ a ete utilise dans des conditions similaires. Il y a eu desactivation du catalyseur et obstruction du reacteur par du carbone apres trois heures d'operation. L'analyse de ce catalyseur a permis de verifier qu'il etait recouvert de carbone en filament. L'analyse du systeme reactionnel a montre que la reaction est controlee par la reaction de. surface et non par le transfert de masse. Par ailleurs, les analyses des catalyseurs de spinelle ont demontre qu'il n'y avait pas de modification de sa forme chimique ni de reduction du spinelle en nickel metallique apres l'utilisation. Mots cles : Reformage a la vapeur, diesel, hydrocarbure liquide, catalyseur, spinelle nickel-alumine, equilibre thermodynamique

Molecular Dynamics Calculations of Optical Nonlinear Properties of Materials

DTIC Science & Technology

1991-12-20

by saturating the hydrogens with five sets each of d and p functions with exponents of 1.0, 0.5, 0.25, 0.125, 0.0625 but for a molecule like ASH 3...of d polarization functions using the exponents suggested by Dykstra et al. A similar calculation was also performed in which a second diffuse p set...one set each of d and p functions with exponents of 0.05 as suggested by DuPuis et al. for larger molecules was used. There was a loss in & of only

Chromosome-wise dissection of the genome of the extremely big mouse line DU6i.

PubMed

Bevova, Marianna R; Aulchenko, Yurii S; Aksu, Soner; Renne, Ulla; Brockmann, Gudrun A

2006-01-01

The extreme high-body-weight-selected mouse line DU6i is a polygenic model for growth research, harboring many small-effect QTL. We dissected the genome of this line into 19 autosomes and the Y chromosome by the construction of a new panel of chromosome substitution strains (CSS). The DU6i chromosomes were transferred to a DBA/2 mice genetic background by marker-assisted recurrent backcrossing. Mitochondria and the X chromosome were of DBA/2 origin in the backcross. During the construction of these novel strains, >4000 animals were generated, phenotyped, and genotyped. Using these data, we studied the genetic control of variation in body weight and weight gain at 21, 42, and 63 days. The unique data set facilitated the analysis of chromosomal interaction with sex and parent-of-origin effects. All analyzed chromosomes affected body weight and weight gain either directly or in interaction with sex or parent of origin. The effects were age specific, with some chromosomes showing opposite effects at different stages of development.

Sorafenib-induced defective autophagy promotes cell death by necroptosis.

PubMed

Kharaziha, Pedram; Chioureas, Dimitris; Baltatzis, George; Fonseca, Pedro; Rodriguez, Patricia; Gogvadze, Vladimir; Lennartsson, Lena; Björklund, Ann-Charlotte; Zhivotovsky, Boris; Grandér, Dan; Egevad, Lars; Nilsson, Sten; Panaretakis, Theocharis

2015-11-10

Autophagy is one of the main cytoprotective mechanisms that cancer cells deploy to withstand the cytotoxic stress and survive the lethal damage induced by anti-cancer drugs. However, under specific conditions, autophagy may, directly or indirectly, induce cell death. In our study, treatment of the Atg5-deficient DU145 prostate cancer cells, with the multi-tyrosine kinase inhibitor, sorafenib, induces mitochondrial damage, autophagy and cell death. Molecular inhibition of autophagy by silencing ULK1 and Beclin1 rescues DU145 cells from cell death indicating that, in this setting, autophagy promotes cell death. Re-expression of Atg5 restores the lipidation of LC3 and rescues DU145 and MEF atg5-/- cells from sorafenib-induced cell death. Despite the lack of Atg5 expression and LC3 lipidation, DU145 cells form autophagosomes as demonstrated by transmission and immuno-electron microscopy, and the formation of LC3 positive foci. However, the lack of cellular content in the autophagosomes, the accumulation of long-lived proteins, the presence of GFP-RFP-LC3 positive foci and the accumulated p62 protein levels indicate that these autophagosomes may not be fully functional. DU145 cells treated with sorafenib undergo a caspase-independent cell death that is inhibited by the RIPK1 inhibitor, necrostatin-1. Furthermore, treatment with sorafenib induces the interaction of RIPK1 with p62, as demonstrated by immunoprecipitation and a proximity ligation assay. Silencing of p62 decreases the RIPK1 protein levels and renders necrostatin-1 ineffective in blocking sorafenib-induced cell death. In summary, the formation of Atg5-deficient autophagosomes in response to sorafenib promotes the interaction of p62 with RIPK leading to cell death by necroptosis.

En-Route Care Capability from Point of Injury Impacts Mortality after Severe Wartime Injury

DTIC Science & Technology

2013-02-01

tranexamic acid .5,6 The greatest proportion of com- bat deaths, however, continue to occur in the prehospital setting, with noncompressible torso...Morrison JJ, DuBose JJ, Rasmussen TE, et al. Military Application of Tranex- amic acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg

Issues of Teacher Education and Inclusion in China

ERIC Educational Resources Information Center

Yu, Lizhong; Su, Xueyun; Liu, Chunling

2011-01-01

Since the 1980s, children with disabilities in China have been integrated into general education settings; the practice is termed "sui ban jiu du", literally "learning in a regular classroom" (LRC). The term LRC means "receiving special education in general education classrooms", and it is regarded as a practical form…

Nailfold Videocapillaroscopic Features and Other Clinical Risk Factors for Digital Ulcers in Systemic Sclerosis: A Multicenter, Prospective Cohort Study.

PubMed

Cutolo, Maurizio; Herrick, Ariane L; Distler, Oliver; Becker, Mike O; Beltran, Emma; Carpentier, Patrick; Ferri, Clodoveo; Inanç, Murat; Vlachoyiannopoulos, Panayiotis; Chadha-Boreham, Harbajan; Cottreel, Emmanuelle; Pfister, Thomas; Rosenberg, Daniel; Torres, Juan V; Smith, Vanessa

2016-10-01

To identify nailfold videocapillaroscopic features and other clinical risk factors for new digital ulcers (DUs) during a 6-month period in patients with systemic sclerosis (SSc). In this multicenter, prospective, observational cohort study, the videoCAPillaroscopy (CAP) study, we evaluated 623 patients with SSc from 59 centers (14 countries). Patients were stratified into 2 groups: a DU history group and a no DU history group. At enrollment, patients underwent detailed nailfold videocapillaroscopic evaluation and assessment of demographic characteristics, DU status, and clinical and SSc characteristics. Risk factors for developing new DUs were assessed using univariable and multivariable logistic regression (MLR) analyses. Of the 468 patients in the DU history group (mean ± SD age 54.0 ± 13.7 years), 79.5% were female, 59.8% had limited cutaneous SSc, and 22% developed a new DU during follow-up. The strongest risk factors for new DUs identified by MLR in the DU history group included the mean number of capillaries per millimeter in the middle finger of the dominant hand, the number of DUs (categorized as 0, 1, 2, or ≥3), and the presence of critical digital ischemia. The receiver operating characteristic (ROC) of the area under the curve (AUC) of the final MLR model was 0.738 (95% confidence interval [95% CI] 0.681-0.795). Internal validation through bootstrap generated a ROC AUC of 0.633 (95% CI 0.510-0.756). This international prospective study, which included detailed nailfold videocapillaroscopic evaluation and extensive clinical characterization of patients with SSc, identified the mean number of capillaries per millimeter in the middle finger of the dominant hand, the number of DUs at enrollment, and the presence of critical digital ischemia at enrollment as risk factors for the development of new DUs. © 2016, American College of Rheumatology.

Nailfold Videocapillaroscopic Features and Other Clinical Risk Factors for Digital Ulcers in Systemic Sclerosis: A Multicenter, Prospective Cohort Study

PubMed Central

Herrick, Ariane L.; Distler, Oliver; Becker, Mike O.; Beltran, Emma; Carpentier, Patrick; Ferri, Clodoveo; Inanç, Murat; Vlachoyiannopoulos, Panayiotis; Chadha‐Boreham, Harbajan; Cottreel, Emmanuelle; Pfister, Thomas; Rosenberg, Daniel; Torres, Juan V.; Cutolo, Maurizio; Herrick, Ariane L.; Distler, Oliver; Becker, Mike; Beltran, Emma; Carpentier, Patrick; Ferri, Clodoveo; Inanç, Murat; Vlachoyiannopoulos, Panayiotis; Smith, Vanessa; Erlacher, L; Hirschl, M; Kiener, HP; Pilger, E; Smith, V; Blockmans, D; Wautrecht, J‐C; Becvár, R; Carpentier, P; Frances, C; Lok, C; Sparsa, A; Hachulla, E; Quere, I; Allanore, Y; Agard, C; Riemekasten, G; Hunzelmann, N; Stücker, M; Ahmadi‐Simab, K; Sunderkötter, C; Wohlrab, J; Müller‐Ladner, U; Schneider, M; Vlachoyianopoulos, P; Vassilopoulos, D; Drosos, A; Antonopoulos, A; Balbir‐Gurman, A; Langevitz, P; Rosner, I; Levy, Y; Cutolo, M; Bombardieri, S; Ferraccioli, G; Mazzuca, S; Grassi, W; Lunardi, C; Airó, P; Riccieri, V; Voskuyl, AE; Schuerwegh, A; Santos, L; Rodrigues, AC; Grilo, A; Amaral, MC; Román Ivorra, JA; Castellvi, I; Distler, O; Spertini, F; Müller, R; Inanç, M; Oksel, F; Turkcapar, N; Herrick, A; Denton, C; McHugh, N; Chattopadhyay, C; Hall, F; Buch, M

2016-01-01

Objective To identify nailfold videocapillaroscopic features and other clinical risk factors for new digital ulcers (DUs) during a 6‐month period in patients with systemic sclerosis (SSc). Methods In this multicenter, prospective, observational cohort study, the videoCAPillaroscopy (CAP) study, we evaluated 623 patients with SSc from 59 centers (14 countries). Patients were stratified into 2 groups: a DU history group and a no DU history group. At enrollment, patients underwent detailed nailfold videocapillaroscopic evaluation and assessment of demographic characteristics, DU status, and clinical and SSc characteristics. Risk factors for developing new DUs were assessed using univariable and multivariable logistic regression (MLR) analyses. Results Of the 468 patients in the DU history group (mean ± SD age 54.0 ± 13.7 years), 79.5% were female, 59.8% had limited cutaneous SSc, and 22% developed a new DU during follow‐up. The strongest risk factors for new DUs identified by MLR in the DU history group included the mean number of capillaries per millimeter in the middle finger of the dominant hand, the number of DUs (categorized as 0, 1, 2, or ≥3), and the presence of critical digital ischemia. The receiver operating characteristic (ROC) of the area under the curve (AUC) of the final MLR model was 0.738 (95% confidence interval [95% CI] 0.681–0.795). Internal validation through bootstrap generated a ROC AUC of 0.633 (95% CI 0.510–0.756). Conclusion This international prospective study, which included detailed nailfold videocapillaroscopic evaluation and extensive clinical characterization of patients with SSc, identified the mean number of capillaries per millimeter in the middle finger of the dominant hand, the number of DUs at enrollment, and the presence of critical digital ischemia at enrollment as risk factors for the development of new DUs. PMID:27111549

Cultural Heritage Documentation and Integrated Geomatics Techniques in AN Educational Context: Case Bois-Du (belgium)

NASA Astrophysics Data System (ADS)

Stal, C.; Goossens, R.; Carlier, L.; Debie, J.; Haoudy, K.; Nuttens, T.; De Wulf, A.

2013-07-01

The Walloon Region in Belgium played a leading role in the world economy and in the industrial sciences and engineering since the 19th century. Several relicts, such as important industrial buildings or sites, are spread over a large area and are still dominating the current landscape. Some of these remnants are preserved as monuments, representing the industrial, cultural and ecological transition of the region during the last two centuries. Since 2012, UNESCO recognized the importance of four of the best preserved 19th and 20th century coal mining sites and classified them as World Heritage ("Major Mining Sites of Wallonia", Le Grand-Hornu, Bois-du- Luc, Le Bois du Cazier and Blegny Mine). The four recognised mining sites together form a strip of about 170 km long, containing important examples of the so-called 'neo classical architecture' from the early periods of the industrial era in continental Europe. Motivated by this recognition and by the huge touristic and educational potential of the sites, a partnership between the Walloon government and Ghent University was organized. In this first stage, the collaboration focuses on the site of Bois-du-Luc in the municipality of La Louvière, containing a large series of dwellings, several equipments built between 1853 and 1923 by the Société des Charbonnages du Bois-du-Luc, workshops and heaps. Consisting of numerous buildings dating back to the period between 1838 and 1923, this site is one of Europe's oldest collieries. The collaboration between the Walloon government and Ghent University - Department of Geography fits in the hands-on training which students in land surveying and geomatics receive during their Bachelor studies. For the students it is very interesting that their practical exercises are not limited to the university campus, but that they are involved in a real measurement campaign. The project consists of a series of intensive land surveying campaigns, resulting in highly detailed and accurate maps of the site, including the inside domain of the buildings. Already available aerial photographs are processed to obtain a 3D model of the site and the wider region. In March 2013, the first campaign took place. During this first campaign, a topographical network was set out and a series of detail points were measured for the detailed topographic mapping. The topographical network was well-planned and covers almost the whole site, forming a set of permanently materialized reference points for later measurements. Besides, a large number of ground control points (GCPs) were taken for the 3D reconstruction of the area, based on high resolution airborne imagery. This enables the students to familiarize themselves with photogrammetric principles in a practical exercise. Both the topographic maps and the 3D model fit within the large scale geographic reference map of the Walloon Region. In this contribution, the results of this intensive trans-regional collaboration on the preservation of the sites are presented. This paper will discuss the first deliverables from the project and the advantages for the responsible government, the cultural heritage organisations (Ecomusée du Bois-du-Luc) and the students. The main focus here is on the educational context of the project. Furthermore, future projects on the same site will be discussed.

Magmatismes tholéiitique et alcalin des demi-grabens crétacés de Mayo Oulo Léré et de Babouri Figuil (Nord du Cameroun Sud du Tchad) en domaine d'extension continentaleTholeiitic and alkaline magmatisms of the Early-Cretaceous half-grabens of Mayo Oulo Léré and Babouri Figuil (Northern Cameroon Southern Chad) in extensional structural settings

NASA Astrophysics Data System (ADS)

Ngounouno, Ismaı̈la; Déruelle, Bernard; Guiraud, René; Vicat, Jean-Paul

2001-08-01

Two major dykes of basalts, microgabbros, olivine dolerites (continental tholeiites), and of camptonites and benmoreites (alkaline rocks) are respectively exposed in the Mayo Oulo-Léré and Babouri-Figuil Early Cretaceous half-grabens (Northern Cameroon-Southern Chad). The tholeiites were probably derived from an asthenospheric source in connection with a lithospheric thinning occurring between Santonian and Eocene times. In contrast, the alkaline rocks may be derived from a deeper metasomatized mantle source.

Toward a Concept of Risk for Effective Military Decision Making

DTIC Science & Technology

2007-12-01

gestion intégrée du risque de 2001 par le Secrétariat du Conseil du Trésor du Canada, (b) de la doctrine interarmées sur la gestion du risque pour les...opérations des FC de 2002 et les documents de politique et les directives de l’intégration de la gestion du risque de 2005 du ministère de la Défense...a) le gouvernement du Canada dans le Cadre de gestion intégrée du risque de

Anthropogenic organic compounds in ground water and finished water of community water systems in the Greater Twin Cities metropolitan area, Minnesota and Wisconsin, 2004–05

USGS Publications Warehouse

Tornes, Lan H.; Stark, James R.; Hoard, Christopher J.; Smith, Erik A.

2007-01-01

Water-quality results from source-water samples were compared to characterize differences between aquifers. VOC and other AOC detections were more frequent in water from the Prairie du Chien-Jordan aquifer compared to the glacial aquifer. Pesticides, however, were detected more frequently in the glacial aquifer. On the basis of study results, the hydrogeologic setting, land use, and aquifer productivity are important in explaining the occurrence of AOCs in community water system wells. Results of this study indicate that monitoring for pesticides in source water generally indicates the potential occurrence of pesticides in finished water but that this is not necessarily true of VOCs. Additional monitoring is needed to better understand the occurrence of other AOCs in source and finished waters.

Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabolism

PubMed Central

Ayuso, Miriam; Fernández, Almudena; Núñez, Yolanda; Benítez, Rita; Isabel, Beatriz; Barragán, Carmen; Fernández, Ana Isabel; Rey, Ana Isabel; Medrano, Juan F.; Cánovas, Ángela; González-Bulnes, Antonio; López-Bote, Clemente; Ovilo, Cristina

2015-01-01

Iberian ham production includes both purebred (IB) and Duroc-crossbred (IBxDU) Iberian pigs, which show important differences in meat quality and production traits, such as muscle growth and fatness. This experiment was conducted to investigate gene expression differences, transcriptional regulation and genetic polymorphisms that could be associated with the observed phenotypic differences between IB and IBxDU pigs. Nine IB and 10 IBxDU pigs were slaughtered at birth. Morphometric measures and blood samples were obtained and samples from Biceps femoris muscle were employed for compositional and transcriptome analysis by RNA-Seq technology. Phenotypic differences were evident at this early age, including greater body size and weight in IBxDU and greater Biceps femoris intramuscular fat and plasma cholesterol content in IB newborns. We detected 149 differentially expressed genes between IB and IBxDU neonates (p < 0.01 and Fold-Change > 1. 5). Several were related to adipose and muscle tissues development (DLK1, FGF21 or UBC). The functional interpretation of the transcriptomic differences revealed enrichment of functions and pathways related to lipid metabolism in IB and to cellular and muscle growth in IBxDU pigs. Protein catabolism, cholesterol biosynthesis and immune system were functions enriched in both genotypes. We identified transcription factors potentially affecting the observed gene expression differences. Some of them have known functions on adipogenesis (CEBPA, EGRs), lipid metabolism (PPARGC1B) and myogenesis (FOXOs, MEF2D, MYOD1), which suggest a key role in the meat quality differences existing between IB and IBxDU hams. We also identified several polymorphisms showing differential segregation between IB and IBxDU pigs. Among them, non-synonymous variants were detected in several transcription factors as PPARGC1B and TRIM63 genes, which could be associated to altered gene function. Taken together, these results provide information about candidate genes, metabolic pathways and genetic polymorphisms potentially involved in phenotypic differences between IB and IBxDU pigs associated to meat quality and production traits. PMID:26695515

Connected. Volume 5, Issue 1, Spring 2013

DTIC Science & Technology

2013-04-18

operational. Fur- thermore, KM will be the force multiplier that allows us to take “KM to the tactical edge”. LTC Mike Kitchens , Chief - Concepts and...KMRs with their du- ties. This handbook is a ’ companion book’ to the KMO handbook, is structured the same way, and has the same perspective. This...general_km_topics/ connected_newsletter AOKMP POCs Jim L. Claunch, 913-684-6793, jimmie.l.claunch.civ@mail.mil LTC Michael Kitchens , 913-684-4498

Simulation-Based Acquisition of the Future Air-Land Combat System (acquisition par la simulation des systemes futurs de combat aeroterresire)

DTIC Science & Technology

2003-11-01

de défense sur des matériels, des hommes et des doctrines préexistants, mais part au contraire d’une analyse des menaces et du... hommes et les doctrines. Comme on le verra ultérieurement, cette nouvelle démarche d’ingénierie du système de défense, qui se veut proactive et non...résolvent sous des contraintes de zéro mort ou tout au moins de pertes minimales, dont l ’« acceptabilité » est essentiellement facteur de

Rescue of a duck circovirus from an infectious DNA clone in ducklings.

PubMed

Li, Pengfei; Zhang, Zhilong; Jia, Renyong; Mao, Sai; Wang, Mingshu; Jia, Ruiling; Liu, Mafeng; Zhu, Dekang; Chen, Shun; Sun, Kunfeng; Yin, Zhongqiong; Chen, Xiaoyue; Cheng, Anchun

2015-05-30

Duck circovirus may predispose the host to immunosuppression and may serve as an immunological trigger for further complicated disease progression. Due to the lack of a cell culture system for propagating DuCV, little is known regarding the molecular biology and pathogenesis of DuCV. The aim of this study was to describe the construction and initial in vivo characterization of full-length DNA clones of DuCV (pIC-Mu2DuCV) and its infectivity under in vivo conditions. The constructed pIC-Mu2DuCV contained two copies of the whole DuCV genome and an introduced Xho I restriction enzyme site. Eighty-one 10-day-old conventional ducklings that were free of DuCV were randomly divided equally into three groups (1, 2 and 3). The ducklings in groups 1, 2 and 3 were inoculated intramuscularly with pIC-Mu2DuCV, wild-type virus GH01 and PBS, respectively. Subsequently, all of the ducklings were examined clinically, which were each given a physical condition score, and their rectal temperatures were taken daily during the experimental period. DuCV genomes in serum samples and in various tissues from all of the ducklings at 0, 1, 3, 5, 7, 10, 15, 21 and 28 DPC were detected by PCR and real-time quantitative PCR, respectively. The average daily weight gain (ADWG) of group 3 was significantly higher than those of groups 1 and 2, and the temperature of all ducklings was stable between 41.7 °C and 42.2 °C. The clinical values (physical condition scores) of groups 1, 2 and 3 were 12.5, 15.6 and 0, respectively. In addition, viremia occurred at 15 and 10 days post-challenge (DPC) in groups 1 and 2, and antibodies could be detected in these ducklings at 21 and 15 DPC. Proliferation ability analysis showed that the viral titers of group 1 were lower than those of their parental viruses in group 2. This study shows that the rescued viruses are not significantly different but exhibit lower pathogenicity and proliferation ability compared with the parental virus. The results will facilitate future studies on DuCV pathogenesis and biology.

A Decomposition of Hospital Profitability: An Application of DuPont Analysis to the US Market.

PubMed

Turner, Jason; Broom, Kevin; Elliott, Michael; Lee, Jen-Fu

2015-01-01

This paper evaluates the drivers of profitability for a large sample of U.S. hospitals. Following a methodology frequently used by financial analysts, we use a DuPont analysis as a framework to evaluate the quality of earnings. By decomposing returns on equity (ROE) into profit margin, total asset turnover, and capital structure, the DuPont analysis reveals what drives overall profitability. Profit margin, the efficiency with which services are rendered (total asset turnover), and capital structure is calculated for 3,255 U.S. hospitals between 2007 and 2012 using data from the Centers for Medicare & Medicaid Services' Healthcare Cost Report Information System (CMS Form 2552). The sample is then stratified by ownership, size, system affiliation, teaching status, critical access designation, and urban or non-urban location. Those hospital characteristics and interaction terms are then regressed (OLS) against the ROE and the respective DuPont components. Sensitivity to regression methodology is also investigated using a seemingly unrelated regression. When the sample is stratified by hospital characteristics, the results indicate investor-owned hospitals have higher profit margins, higher efficiency, and are substantially more leveraged. Hospitals in systems are found to have higher ROE, margins, and efficiency but are associated with less leverage. In addition, a number of important and significant interactions between teaching status, ownership, location, critical access designation, and inclusion in a system are documented. Many of the significant relationships, most notably not-for-profit ownership, lose significance or are predominately associated with one interaction effect when interaction terms are introduced as explanatory variables. Results are not sensitive to the alternative methodology. The results of the DuPont analysis suggest that although there appears to be convergence in the behavior of NFP and IO hospitals, significant financial differences remain depending on their respective hospital characteristics. Those differences are tempered or exacerbated by location, size, teaching status, system affiliation, and critical access designation. With the exception of cost-based reimbursement for critical access hospitals, emerging payment systems are placing additional financial pressures on hospitals. The financial pressures being applied treat hospitals as a monolithic category and, given the delicate and often negative ROE for many hospitals, the long-term stability of the healthcare facility infrastructure may be negatively impacted.

The Axial Age and the Problems of the Twentieth Century: Du Bois, Jaspers, and Universal History.

PubMed

Boy, John D

The axial age debate has put big questions of social and cultural change back on the agenda of sociology. This paper takes this development as an occasion to reflect on how social thought works with (and against) nineteenth-century intellectual traditions in its efforts to understand history on a macro scale. Karl Jaspers, who initially formulated the axial age thesis in The Origin and Goal of History , revised the Hegelian account of world history by broadening the scope of the narrative to encompass all civilizations participating in the events of the first millennium BCE that saw the rise of major philosophical and religious traditions. However, his account, like the earlier philosophical accounts he seeks to improve upon, privileges cognitive developments over material practices and social interactions, and as such offers little to those seeking to make sense of how cultural patterns interact with others and spread. Here another social theorist engaging with Hegel, W. E. B. Du Bois, provides a helpful contrast. His account of the development of double-consciousness in "Of Our Spiritual Strivings," the opening chapter of The Souls of Black Folk , helps us to understand experiences of encounter and the perduring historical effects they may have. Du Bois' relational theory reminds us of the importance of unpacking abstractions and understanding processes in terms of social interactions.

Separation and Depleted Uranium Fragments from Gun Test Catchment. Volume 2. Catchment System and Separations Methods

DTIC Science & Technology

1993-12-30

projectile fragments from target materials, principally sand. Phase I activities included (1) literature review of separations technology , (2) site visits, (3...the current operation, evaluation of alternative means for separation of DU from sand, a review of uranium mining technology for v possible...the current operation, evaluation of alternative means for separation of DU from sand, a review of uranium mining technology for possible

Umbral moonshine and K3 surfaces

DOE PAGES

Cheng, Miranda C. N.; Harrison, Sarah

2015-06-25

Recently, 23 cases of umbral moonshine, relating mock modular forms and finite groups, have been discovered in the context of the 23 even unimodular Niemeier lattices. One of the 23 cases in fact coincides with the so-called Mathieu moonshine, discovered in the context of K3 non-linear sigma models. In this paper we establish a uniform relation between all 23 cases of umbral moonshine and K3 sigma models, and thereby take a first step in placing umbral moonshine into a geometric and physical context. In addition, this is achieved by relating the ADE root systems of the Niemeier lattices to themore » ADE du Val singularities that a K3 surface can develop, and the configuration of smooth rational curves in their resolutions. A geometric interpretation of our results is given in terms of the marking of K3 surfaces by Niemeier lattices.« less

Cancer du sein bilatéral synchrone au Maroc: caractéristiques épidémiologiques et cliniques

PubMed Central

Boufettal, Houssine; Samouh, Naïma

2015-01-01

Préciser la fréquence, les facteurs de risque et le pronostic du cancer du sein bilatéral, à partir d'une étude rétrospective de 22 cas de cancer du sein bilatéral synchrone dans un pays du Maghreb. De 2002 à 2010, 625 patientes étaient prises en charge pour cancer du sein au service de Gynécologie-Obstétrique «C» du centre hospitalier universitaire de Casablanca. 22 cas de cancer bilatéral synchrone étaient diagnostiqués. Nos résultats sont comparés avec ceux de la littérature. La fréquence de la bilatéralité du cancer du sein synchrone était de 3,52% (22/625). L'intervalle de temps moyen entre les deux cancers est de 4 mois (0 à 6 mois). Les patientes âgées de moins de 40 ans lors du premier cancer avaient six fois plus de risque de développer un cancer au niveau du sein controlatéral que les femmes âgées de plus de 40 ans. Les patientes atteintes d'une tumeur T3 ou T4 avaient un risque neuf fois plus élevé que les autres. 90,9% (2/22) des cas des premiers cancers sont des adénocarcinomes infiltrants. Les types histologiques du premier et du douzième cancer étaient identiques dans 86,4% (19/22) des cas. Quant au pronostic, il dépend à la fois du stade du premier et du deuxième cancer et le traitement de ce dernier doit obéir aux mêmes règles du traitement du premier cancer. L'incidence du cancer bilatéral synchrone du sein est de 3,52% dans notre série. Le cancer du sein unilatéral constitue un facteur de risque de développement d'un cancer du sein controlatéral. Une surveillance à vie est nécessaire au cours d'un cancer du sein pour détecter un cancer controlatéral. PMID:26090066

Generation of silver standard concept annotations from biomedical texts with special relevance to phenotypes.

PubMed

Oellrich, Anika; Collier, Nigel; Smedley, Damian; Groza, Tudor

2015-01-01

Electronic health records and scientific articles possess differing linguistic characteristics that may impact the performance of natural language processing tools developed for one or the other. In this paper, we investigate the performance of four extant concept recognition tools: the clinical Text Analysis and Knowledge Extraction System (cTAKES), the National Center for Biomedical Ontology (NCBO) Annotator, the Biomedical Concept Annotation System (BeCAS) and MetaMap. Each of the four concept recognition systems is applied to four different corpora: the i2b2 corpus of clinical documents, a PubMed corpus of Medline abstracts, a clinical trails corpus and the ShARe/CLEF corpus. In addition, we assess the individual system performances with respect to one gold standard annotation set, available for the ShARe/CLEF corpus. Furthermore, we built a silver standard annotation set from the individual systems' output and assess the quality as well as the contribution of individual systems to the quality of the silver standard. Our results demonstrate that mainly the NCBO annotator and cTAKES contribute to the silver standard corpora (F1-measures in the range of 21% to 74%) and their quality (best F1-measure of 33%), independent from the type of text investigated. While BeCAS and MetaMap can contribute to the precision of silver standard annotations (precision of up to 42%), the F1-measure drops when combined with NCBO Annotator and cTAKES due to a low recall. In conclusion, the performances of individual systems need to be improved independently from the text types, and the leveraging strategies to best take advantage of individual systems' annotations need to be revised. The textual content of the PubMed corpus, accession numbers for the clinical trials corpus, and assigned annotations of the four concept recognition systems as well as the generated silver standard annotation sets are available from http://purl.org/phenotype/resources. The textual content of the ShARe/CLEF (https://sites.google.com/site/shareclefehealth/data) and i2b2 (https://i2b2.org/NLP/DataSets/) corpora needs to be requested with the individual corpus providers.

Using a probabilistic approach in an ecological risk assessment simulation tool: test case for depleted uranium (DU).

PubMed

Fan, Ming; Thongsri, Tepwitoon; Axe, Lisa; Tyson, Trevor A

2005-06-01

A probabilistic approach was applied in an ecological risk assessment (ERA) to characterize risk and address uncertainty employing Monte Carlo simulations for assessing parameter and risk probabilistic distributions. This simulation tool (ERA) includes a Window's based interface, an interactive and modifiable database management system (DBMS) that addresses a food web at trophic levels, and a comprehensive evaluation of exposure pathways. To illustrate this model, ecological risks from depleted uranium (DU) exposure at the US Army Yuma Proving Ground (YPG) and Aberdeen Proving Ground (APG) were assessed and characterized. Probabilistic distributions showed that at YPG, a reduction in plant root weight is considered likely to occur (98% likelihood) from exposure to DU; for most terrestrial animals, likelihood for adverse reproduction effects ranges from 0.1% to 44%. However, for the lesser long-nosed bat, the effects are expected to occur (>99% likelihood) through the reduction in size and weight of offspring. Based on available DU data for the firing range at APG, DU uptake will not likely affect survival of aquatic plants and animals (<0.1% likelihood). Based on field and laboratory studies conducted at APG and YPG on pocket mice, kangaroo rat, white-throated woodrat, deer, and milfoil, body burden concentrations observed fall into the distributions simulated at both sites.

Controlling the digital ulcerative disease in systemic sclerosis is associated with improved hand function.

PubMed

Mouthon, Luc; Carpentier, Patrick H; Lok, Catherine; Clerson, Pierre; Gressin, Virginie; Hachulla, Eric; Bérezné, Alice; Diot, Elisabeth; Van Kien, Aurélie Khau; Jego, Patrick; Agard, Christian; Duval-Modeste, Anne-Bénédicte; Sparsa, Agnès; Puzenat, Eve; Richard, Marie-Aleth

2017-06-01

Ischemic digital ulcers (DU) represent a major complication of systemic sclerosis (SSc). We investigated the impact of controlling the ulcerative disease on disability, pain, and quality of life in SSc patients receiving bosentan. ECLIPSE (Study AC-052-517) is a 2-year prospective, multicenter, and observational study. Patients with SSc who experienced at least 1 DU in the previous year and received bosentan were included between October 2009 and March 2011. Disability scores [Cochin Hand Function Scale (CHFS) and Health Assessment Questionnaire Disability Index (HAQ-DI)], pain scores (visual analog scale), and quality-of-life scores (SF-36) were collected at inclusion and 1 year later (primary endpoint). A controlled ulcerative disease was defined by the absence of ongoing/new DU episode between inclusion and 1-year follow-up. Data were available at 1 year for 120 patients out of 190 included. During follow-up, 46 (38.3%) patients experienced a new DU episode. The number of DU per patient decreased from 1.4 ± 1.8 at inclusion to 0.6 ± 1.6 (p < 0.0001) at 1 year. Disability scores decreased from 1.0 ± 0.7 to 0.9 ± 0.7 (p = 0.04) for the HAQ-DI and from 29 ± 20 to 25 ± 20 (p = 0.005) for the CHFS; the pain score decreased from 4.3 ± 3.1 to 2.9 ± 2.8 (p < 0.0001). This improvement was attributed to patients with a controlled ulcerative disease (48.3%), who significantly improved HAQ-DI (p = 0.04), CHFS (p = 0.04), and pain score (p = 0.046). In patients with SSc, control of the ulcerative disease for 1 year was associated with significant attenuation of hand disability. Copyright © 2017 Elsevier Inc. All rights reserved.

Caracterisation des revetements par projection thermique a haute vitesse obtenus a partir de differentes poudres de wc-10co-4cr pour des applications en aeronautique =

NASA Astrophysics Data System (ADS)

Quintero Malpica, Alfonso

Les revetements par projection thermique HVOF (High Velocity Oxy-Fuel) sont communement utilises dans l'industrie aeronautique, notamment au sein du partenaire industriel du projet (Tecnickrome Aeronautique Inc), comme des remplacants pour les revetements produits par l'electrodeposition du chrome dur due aux problemes environnementaux. Ce projet avait pour but de trouver une poudre alternative a celle qui est actuellement utilisee pour la production des revetements de type WC-10Co-4Cr obtenus avec la technologie de projection thermique a haute vitesse HVOF et en utilisant le systeme de projection HVOF-JET KOTERTM III. Dans un premier temps, cinq poudres incluant celle de reference, ayant des distributions granulometriques differentes, ont ete projetees dans le but d'identifier quelles poudres pouvaient etre utilisees avec le systeme de projection HVOF-JET KOTERTM III en gardant des parametres similaires (debit d'hydrogene, debit d'oxygene, debit de poudre et distance de projection) que pour la poudre de reference. Les revetements obtenus a partir des poudres etudiees ont ete evalues selon les criteres d'acceptation des revetements sollicites par les principaux manufacturiers des trains d'atterrissage. Les tests ont porte sur l'epaisseur, l'adhesion, la microstructure, la microdurete, les contraintes residuelles et la rugosite. A partir des resultats obtenus, seulement deux poudres ont rencontre toutes les proprietes demandees par les specifications aeronautiques. L'influence de la variation de la distance de projection sur la qualite des revetements a ete etudiee. Cinq distances (100, 125, 150, 175 et 200 mm) ont ete choisies pour faire la projection des deux poudres selectionnees. Les revetements obtenus ont montre de proprietes des revetements similaires (epaisseur, adhesion, microstructure, microdurete, contraintes residuelles et rugosite). Il a ete trouve que la distance de projection est un parametre indirect du systeme de projection HVOF-JET KOTERTM III et qu'autant la vitesse que la temperature des particules semblent mieux determiner les proprietes du revetement, en particulier, les niveaux de contraintes residuelles finales dans les revetements. Lorsque les revetements sont produits a de courtes distances de projection, les particules arrivent avec plus grande vitesse et temperature ce qui resulte dans de plus grandes temperatures du substrat et plus grande energie d'impact, resultant dans de plus grandes contraintes residuelles de compression dans les revetements.

Fabrication de memoire monoelectronique non volatile par une approche de nanogrille flottante

NASA Astrophysics Data System (ADS)

Guilmain, Marc

Les transistors monoelectroniques (SET) sont des dispositifs de tailles nanometriques qui permettent la commande d'un electron a la fois et donc, qui consomment peu d'energie. Une des applications complementaires des SET qui attire l'attention est son utilisation dans des circuits de memoire. Une memoire monoelectronique (SEM) non volatile a le potentiel d'operer a des frequences de l'ordre des gigahertz ce qui lui permettrait de remplacer en meme temps les memoires mortes de type FLASH et les memoires vives de type DRAM. Une puce SEM permettrait donc ultimement la reunification des deux grands types de memoire au sein des ordinateurs. Cette these porte sur la fabrication de memoires monoelectroniques non volatiles. Le procede de fabrication propose repose sur le procede nanodamascene developpe par C. Dubuc et al. a 1'Universite de Sherbrooke. L'un des avantages de ce procede est sa compatibilite avec le back-end-of-line (BEOL) des circuits CMOS. Ce procede a le potentiel de fabriquer plusieurs couches de circuits memoirestres denses au-dessus de tranches CMOS. Ce document presente, entre autres, la realisation d'un simulateur de memoires monoelectroniques ainsi que les resultats de simulations de differentes structures. L'optimisation du procede de fabrication de dispositifs monoelectroniques et la realisation de differentes architectures de SEM simples sont traitees. Les optimisations ont ete faites a plusieurs niveaux : l'electrolithographie, la gravure de l'oxyde, le soulevement du titane, la metallisation et la planarisation CMP. La caracterisation electrique a permis d'etudier en profondeur les dispositifs formes de jonction de Ti/TiO2 et elle a demontre que ces materiaux ne sont pas appropries. Par contre, un SET forme de jonction de TiN/Al2O3 a ete fabrique et caracterise avec succes a basse temperature. Cette demonstration demontre le potentiel du procede de fabrication et de la deposition de couche atomique (ALD) pour la fabrication de memoires monoelectroniques. Mots-cles: Transistor monoelectronique (SET), memoire monoelectronique (SEM), jonction tunnel, temps de retention, nanofabrication, electrolithographie, planarisation chimicomecanique.

Regional rainfall-runoff relations for simulation of streamflow for watersheds in Du Page County, Illinois

USGS Publications Warehouse

Duncker, James J.; Melching, Charles S.

1998-01-01

Rainfall and streamflow data collected from July 1986 through September 1993 were utilized to calibrate and verify a continuous-simulation rainfall-runoff model for three watersheds (11.8--18.0 square miles in area) in Du Page County. Classification of land cover into three categories of pervious (grassland, forest/wetland, and agricultural land) and one category of impervious subareas was sufficient to accurately simulate the rainfall-runoff relations for the three watersheds. Regional parameter sets were obtained by calibrating jointly all parameters except fraction of ground-water inflow that goes to inactive ground water (DEEPFR), interflow recession constant (IRC), and infiltration (INFILT) for runoff from all three watersheds. DEEPFR and IRC varied among the watersheds because of physical differences among the watersheds. Two values of INFILT were obtained: one representing the rainfall-runoff process on the silty and clayey soils on the uplands and lake plains that characterize Sawmill Creek, St. Joseph Creek, and eastern Du Page County; and one representing the rainfall-runoff process on the silty soils on uplands that characterize Kress Creek and parts of western Du Page County. Regional rainfall-runoff relations, defined through joint calibration of the rainfall-runoff model and verified for independent periods, presented in this report, allow estimation of runoff for watersheds in Du Page County with an error in the total water balance less than 4.0 percent; an average absolute error in the annual-flow estimates of 17.1 percent with the error rarely exceeding 25 percent for annual flows; and correlation coefficients and coefficients of model-fit efficiency for monthly flows of at least 87 and 76 percent, respectively. Close reproduction of the runoff-volume duration curves was obtained. A frequency analysis of storm-runoff volume indicates a tendency of the model to undersimulate large storms, which may result from underestimation of the amount of impervious land cover in the watershed and errors in measuring rainfall for convective storms. Overall, the results of regional calibration and verification of the rainfall-runoff model indicate the simulated rainfall-runoff relations are adequate for stormwater-management planning and design for watersheds in Du Page County.

The short arm deletion syndrome of chromosome 4 (4p- syndrome).

PubMed

Zellweger, H; Bardach, J; Bordwell, J; Williams, K

1975-01-01

Partial deletion of the short arm of chromosome 4 (4p-) represents another (rare) cause of cleft lip and cleft palate. Further characteristic manifestations of the syndrome (also called Wolf or Wolf-Hirschhorn syndrome) are growth failure, microcephaly, prominent glabella, hypertelorism, beaked nose, poorly differentiated and low set ears, cardiac and renal malformation and hypospadias. Life expectancy is often shortened. The 4p- syndrome has many features in common with another deletion syndrome, the cri-du-chat syndrome, and also with the Smith-Lemli-Opitz syndrome. The latter is a hereditary condition with normal karyotype. The cri-du-chat syndrome is characterized by a peculiar high-pitched, mewing cry and can be differentiated from the Wolf syndrome by the different staining characteristics (banding) of chromosomes 4 and 5.

Development Unit Configuration and Current Status of the MIP/MAAC Experiment

NASA Technical Reports Server (NTRS)

Karlmann, P. B.; Johnson, K. R.; Rapp, D.; Wu, J. J.

1999-01-01

The Mars In-Situ Propellant Production (ISPP) Precursor (MIP) experiment package is planned for inclusion on the Mars 2001 Lander. This experiment package consists of five experiments whose purpose is to demonstrate the performance of various ISPP processes in-situ on Mars. The demonstrated ability to produce propellant for Mars Return Vehicles (MRV) is considered to be a necessary precursor to any future manned mission to Mars. The Mars Atmosphere Acquisition and Compression (MAAC) experiment is part of the MIP package and is intended to demonstrate that, by using a sorption compressor, CO2 can be preferentially adsorbed at about 6 torr from the Mars atmosphere during the night when the bed is cold then subsequently compressed to about 800 torr by heating the bed and desorbing CO2 during the day. The compressed CO2 produced by MAAC is to be fed to the Oxygen Generator Subsystem (OGS) where pure oxygen is to be produced. Pure oxygen is considered to be one of the primary constituents of a future manned MRV propellant system. A MAAC Development Unit (DU) has been fabricated and tested at JPL. The MAAC DU consists of 1) a sorption bed filled with a CO2 selective sorbent material, 2) a purge system to be used to periodically backflush non-CO2 gases from the sorbent bed during adsorption, 3) a JPL-developed gas-gap heat switch that allows heat transfer to a radiator for heat removal from the bed during the night time adsorption period and that impedes heat transfer during the day time desorption period, 4) a radiator to radiate heat to the night sky during the adsorption period, 5) a set of three isolation valves and connecting tubing. 6) two pressure transducers and several thermocouples for monitoring the MAAC operating conditions, and command and data handling electronics. This paper will describe the operational theory and the configuration of the MAAC DU and will discuss the current status of the MAAC experiment development including some selected results of performance testing that has been completed prior to the ISRU III meeting.

Development Unit Configuration Status of the MIP/MAAC Experiment

NASA Technical Reports Server (NTRS)

Karlmann, P. B.; Johnson, K. R.; Rapp, D.; Wu, J. J.

1999-01-01

The Mars In-Situ Propellant Production (ISPP) Precursor (MIP) experiment package is planned for inclusion on the Mars 2001 Lander. This experiment package consists of five experiments whose purpose is to demonstrate the performance of various ISPP processes in-situ on Mars. The demonstrated ability to produce propellant for Mars Return Vehicles (MRV) is considered to be a necessary precursor to any future manned mission to Mars. The Mars Atmosphere Acquisition and Compression (MAAC) experiment is part of the MIP package and is intended to demonstrate that, by using a sorption compressor, CO2 can be preferentially adsorbed at about 6 torr from the Mars atmosphere during the night when the bed is cold then subsequently compressed to about 800 torr by heating the bed and desorbing C02 during the day. The compressed CO2 produced by MAAC is to be fed to the Oxygen Generator Subsystem (OGS) where pure oxygen is to be produced. Pure oxygen is considered to be one of the primary constituents of a future manned MRV propellant system. A MAAC Development Unit (DU) has been fabricated and tested at JPL. The MAAC DU consists of: (1) a sorption bed filled with a CO2 selective sorbent material; (2) a purge system to be used to periodically backflush non-CO2 gases from the sorbent bed during adsorption; (3) a JPL-developed gas-gap heat switch that allows heat transfer to a radiator for heat removal from the bed during the night time adsorption period and that impedes heat transfer during the day time desorption period; (4) a radiator to radiate heat to the night sky during the adsorption period; (5) a set of three isolation valves and connecting tubing; (6) two pressure transducers and several thermocouples for monitoring the MAAC operating conditions, and command and data handling electronics. This paper will describe the operational theory and the configuration of the MAAC DU and will discuss the current status of the MAAC experiment development including some selected results of performance testing that has been completed prior to the ISRU III meeting.

Effects of depleted uranium on the health and survival of Ceriodaphnia dubia and Hyalella azteca

USGS Publications Warehouse

Kuhne, W.W.; Caldwell, C.A.; Gould, W.R.; Fresquez, P.R.; Finger, S.

2002-01-01

Depleted uranium (DU) has been used as a substitute for the fissionable enriched uranium component of atomic weapons tested at Los Alamos National Laboratory (LANL) (Los Alamos, NM, USA) since the early 1950s, resulting in considerable concentrations of DU in the soils within the test sites. Although the movement of DU into major aquatic systems has been shown to be minimal, there are many small-order ephemeral streams and areas of standing water in canyons throughout LANL that may be affected by inputs of DU via runoff, erosion, and leaching. Ninety-six-hour acute and 7-d chronic toxicity assays were conducted to measure the toxicity of DU on survival and reproduction of Ceriodaphnia dubia. A 14-d water-only assay was conducted to measure survival and growth of Hyalella azteca. The estimated median lethal concentration (LC50) to produce 50% mortality of the test population for the 96-h Ceriodaphnia dubia assay was 10.50 mg/L. Reproductive effects occurred at a lowest-observable-effect concentration ???3.91 mg/L with a no-observable-effect concentration of 1.97 mg/L. The estimated 14-d LC50 for the Hyalella azteca assay was 1.52 mg/L No significant relationship was detected between growth and DU concentrations. Concentrations at which toxicity effects were observed in this study for both invertebrates exceeded concentrations of total uranium observed in runoff from LANL lands. Thus, it is likely that current runoff levels of uranium do not pose a threat to these types of aquatic invertebrates.

Identification and Expression Analysis of the Interferon-Induced Protein with Tetratricopeptide Repeats 5 (IFIT5) Gene in Duck (Anas platyrhynchos domesticus)

PubMed Central

Mu, Chunyu; Su, Yanhui; Liu, Ran; Huang, Zhengyang; Li, Yang; Yu, Qingming; Chang, Guobin; Xu, Qi; Chen, Guohong

2015-01-01

The interferon-induced proteins with tetratricopeptide repeats (IFITs) protein family mediates antiviral effects by inhibiting translation initiation, cell proliferation, and migration in the interferon (IFN) dependent innate immune system. Several members of this family, including IFIT1, IFIT2, IFIT3 and IFIT5, have been heavily studied in mammals. Avian species contain only one family member, IFIT5, and little is known about the role of this protein in birds. In this study, duck IFIT5 (duIFIT5) full-length mRNA was cloned by reverse transcription polymerase chain reaction (RT-PCR) and rapid amplification of the cDNA ends (RACE). Based on the sequence obtained, we performed a series of bioinformatics analyses, and found that duIFIT5 was most similar to homologs in other avian species. Also, duIFIT5 contained eight conserved TPR motifs and two conserved multi-domains (TPR_11 and TPR_12). Finally, we used duck hepatitis virus type 1 (DHV-1) and polyriboinosinicpolyribocytidylic acid (poly (I:C)) as a pathogen or a pathogen-associated molecular pattern induction to infect three-day-old domestic ducklings. The liver and spleen were collected to detect the change in duIFIT5 transcript level upon infection by quantitative real-time PCR (qRT-PCR). DuIFIT5 expression rapidly increased after DHV-1 infection and maintained a high level, while the transcripts of duIFIT5 peaked at 8h after poly (I:C) infection and then returned to normal. Taken together, these results provide a greater understanding of avian IFIT5. PMID:25816333

Cost-effective technology advancement directions for electric propulsion transportation systems in earth-orbital missions

NASA Technical Reports Server (NTRS)

Regetz, J. D., Jr.; Terwilliger, C. H.

1979-01-01

The directions that electric propulsion technology should take to meet the primary propulsion requirements for earth-orbital missions in the most cost effective manner are determined. The mission set requirements, state of the art electric propulsion technology and the baseline system characterized by it, adequacy of the baseline system to meet the mission set requirements, cost optimum electric propulsion system characteristics for the mission set, and sensitivities of mission costs and design points to system level electric propulsion parameters are discussed. The impact on overall costs than specific masses or costs of propulsion and power systems is evaluated.

An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy.

PubMed

Nuttens, V E; Nahum, A E; Lucas, S

2011-01-01

Urethral NTCP has been determined for three prostates implanted with seeds based on (125)I (145 Gy), (103)Pd (125 Gy), (131)Cs (115 Gy), (103)Pd-(125)I (145 Gy), or (103)Pd-(131)Cs (115 Gy or 130 Gy). First, DU(20), meaning that 20% of the urhral volume receive a dose of at least DU(20), is converted into an I-125 LDR equivalent DU(20) in order to use the urethral NTCP model. Second, the propagation of uncertainties through the steps in the NTCP calculation was assessed in order to identify the parameters responsible for large data uncertainties. Two sets of radiobiological parameters were studied. The NTCP results all fall in the 19%-23% range and are associated with large uncertainties, making the comparison difficult. Depending on the dataset chosen, the ranking of NTCP values among the six seed implants studied changes. Moreover, the large uncertainties on the fitting parameters of the urethral NTCP model result in large uncertainty on the NTCP value. In conclusion, the use of NTCP model for permanent brachytherapy is feasible but it is essential that the uncertainties on the parameters in the model be reduced.

Artificial Neural Network Approaches in Guidance and Control (Les Reseaux Neuroniques Artificiels, Voie a Explorer dans le Domaine du Guidage et du Pilotage)

DTIC Science & Technology

1991-09-01

34 ofetworker eqmpleuoaorreation withbounethat basis vectors (Lawley & Maxwell , 1963). naletwk arn ungd eqatsi wthe boune E It is possible to think of the...passive sonar system IJCNN- signal Aerospace Technology Center, John 89 Washington proceedings Hopkins University) Analysis of hidden Succesful use of...establish the weighted equations and C3 applications interconnmctions of the net and electronic feedback based AUTH: A/CONNELL, JOHN C ., JR. CORP, Naval

W. E. B. Du Bois's Basic American Negro Creed and the Associates in Negro Folk Education: A Case of Repressive Tolerance in the Censorship of Radical Black Discourse on Adult Education

ERIC Educational Resources Information Center

Guy, Talmadge C.; Brookfield, Stephen

2009-01-01

W. E. B. Du Bois, one of the brightest lights in African American history, wrote a sparkling critique of the American social and economic system originally planned as part of the Bronze Booklets series, edited and published by Alain Locke and the Associates in Negro Folk Education. The piece was never published and has, until now, been lost to the…

Nailfold Capillaroscopy and Clinical Applications in Systemic Sclerosis.

PubMed

Smith, Vanessa; Thevissen, Kristof; Trombetta, Amelia C; Pizzorni, Carmen; Ruaro, Barbara; Piette, Yves; Paolino, Sabrina; De Keyser, Filip; Sulli, Alberto; Melsens, Karin; Cutolo, Maurizio

2016-07-01

Capillary microscopy is a safe and non-invasive tool to evaluate the morphology of the microcirculation typically affected in SSc. Next to being paramount for the "(very) early" diagnosis of SSc eyes are also geared toward capillaroscopy with the aim to be able to use it as a biomarker, especially in the prediction of future occurrence of DU. The following review will explain what capillary microscopy is and will focus additionally on studies evaluating the association between capillaroscopy and DU. © 2016 John Wiley & Sons Ltd.

Tracking the NOvA Detectors' Performance

NASA Astrophysics Data System (ADS)

Psihas, Fernanda; NOvA Collaboration

2016-03-01

The NOvA experiment measures long baseline νμ -->νe oscillations in Fermilab's NuMI beam. We employ two detectors equipped with over 10 thousand sets of data-taking electronics; avalanche photo diodes and front end boards which collect and process the scintillation signal from particle interactions within the detectors. These sets of electronics -as well as the systems which power and cool them- must be monitored and maintained at precise working conditions to ensure maximal data-taking uptime, good data quality and a lasting life for our detectors. This poster describes the automated systems used on NOvA to simultaneously monitor our data quality, diagnose hardware issues, track our performance and coordinate maintenance for the detectors.

Self-Monitoring as a Means to Generalize Social Skills

ERIC Educational Resources Information Center

Childs, Deborah

2012-01-01

Social skills are important for success in school as well as in life. Social skills training (SST) has been effective in teaching students required skills within the context of the training site, but often these have not generalized to additional settings (DuPaul & Eckert, 1994). This study researches the effect of adding self-management to an…

Grade 12 Diploma Examination. Examen en vue du diplome douzieme annee. Complete Set, January 1990.

ERIC Educational Resources Information Center

Alberta Dept. of Education, Edmonton.

The Alberta (Canada) Department of Education issues "Grade 12 Diploma Examinations" for various disciplines every six months (dated January and June of each year). Except for the English and Francais examinations (which are issued only in their own language), the examinations are issued in an English edition and a French edition. The…

La Parabole du Gaucher et de la Casserole a Bec Verseur: Etude des Processus d'Apprentissage dans un Environnement de Calculatrices Symboliques.

ERIC Educational Resources Information Center

Trouche, Luc

2000-01-01

Discusses the problems of conceptualization of the function limit in technological environments (principally graphing calculators today and symbolic calculators tomorrow) that are gradually being adopted in precalculus teaching. Explains how the instrumentation process and the conceptualization process are dependent on each other. Sets forth a…

Environmental assessment of depleted uranium used in military armor-piercing rounds in terrestrial systems.

PubMed

Stanley, Jacob K; Coleman, Jessica G; Brasfield, Sandra M; Bednar, Anthony J; Ang, Choo Y

2014-06-01

Depleted uranium (DU) from the military testing and use of armor-piercing kinetic energy penetrators has been shown to accumulate in soils; however, little is known about the toxicity of DU geochemical species created through corrosion or weathering. The purpose of the present study was to assess the toxic effects and bioaccumulation potential of field-collected DU oxides to the model terrestrial invertebrates Eisenia fetida (earthworm) and Porcellio scaber (isopod). Earthworm studies were acute (72 h) dermal exposures or 28-d spiked soil exposures that used noncontaminated field-collected soils from the US Army's Yuma and Aberdeen Proving Grounds. Endpoints assessed in earthworm testing included bioaccumulation, growth, reproduction, behavior (soil avoidance), and cellular stress (neutral red uptake in coelomocytes). Isopod testing used spiked food, and endpoints assessed included bioaccumulation, survival, and feeding behavior. Concentration-dependent bioaccumulation of DU in earthworms was observed with a maximum bioaccumulation factor of 0.35; however, no significant reductions in survival or impacts to cellular stress were observed. Reproduction lowest-observed-effect concentrations (LOEC) of 158 mg/kg and 96 mg/kg were observed in Yuma Proving Ground and a Mississippi reference soil (Karnac Ferry), respectively. Earthworm avoidance of contaminated soils was not observed in 48-h soil avoidance studies; however, isopods were shown to avoid food spiked with 12.7% by weight DU oxides through digital tracking studies. © 2014 SETAC.

Depleted uranium induces neoplastic transformation in human lung epithelial cells.

PubMed

Xie, Hong; LaCerte, Carolyne; Thompson, W Douglas; Wise, John Pierce

2010-02-15

Depleted uranium (DU) is commonly used in military armor and munitions, and thus, exposure of soldiers and noncombatants is frequent and widespread. Previous studies have shown that DU has both chemical and radiological toxicity and that the primary route of exposure of DU to humans is through inhalation and ingestion. However, there is limited research information on the potential carcinogenicity of DU in human bronchial cells. Accordingly, we determined the neoplastic transforming ability of particulate DU to human bronchial epithelial cells (BEP2D). We observed the loss of contact inhibition and anchorage independent growth in cells exposed to DU after 24 h. We also characterized these DU-induced transformed cell lines and found that 40% of the cell lines exhibit alterations in plating efficiency and no significant changes in the cytotoxic response to DU. Cytogenetic analyses showed that 53% of the DU-transformed cell lines possess a hypodiploid phenotype. These data indicate that human bronchial cells are transformed by DU and exhibit significant chromosome instability consistent with a neoplastic phenotype.

Extraction studies. Final report, May 6, 1996--September 30, 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

During the first week of this effort, an Alpkem RFA-300 4-channel automated chemical analyzer was transferred to the basement of building 42 at TA-46 for the purpose of performing extraction studies. Initially, this instrumentation was applied to soil samples known to contain DNA. Using the SFA (Segmented Flow Analysis) technique, several fluidic systems were evaluated to perform on-line filtration of several varieties of soil obtained from Cheryl Kuske and Kaysie Banton (TA-43, Bldg. 1). Progress reports were issued monthly beginning May 15, 1996. Early in 1997 there was a shift from the conventional 2-phase system (aqueous + air) to amore » 3-phase system (oil + aqueous + air) to drastically reduce sample size and reagent consumption. Computer animation was recorded on videotape for presentations. The time remaining on the subcontract was devoted to setting up existing equipment to incorporate the 3rd phase (a special fluorocarbon oil obtained from DuPont).« less

The impact of homologous recombination repair deficiency on depleted uranium clastogenicity in Chinese hamster ovary cells: XRCC3 protects cells from chromosome aberrations, but increases chromosome fragmentation.

PubMed

Holmes, Amie L; Joyce, Kellie; Xie, Hong; Falank, Carolyne; Hinz, John M; Wise, John Pierce

2014-04-01

Depleted uranium (DU) is extensively used in both industry and military applications. The potential for civilian and military personnel exposure to DU is rising, but there are limited data on the potential health hazards of DU exposure. Previous laboratory research indicates DU is a potential carcinogen, but epidemiological studies remain inconclusive. DU is genotoxic, inducing DNA double strand breaks, chromosome damage and mutations, but the mechanisms of genotoxicity or repair pathways involved in protecting cells against DU-induced damage remain unknown. The purpose of this study was to investigate the effects of homologous recombination repair deficiency on DU-induced genotoxicity using RAD51D and XRCC3-deficient Chinese hamster ovary (CHO) cell lines. Cells deficient in XRCC3 (irs1SF) exhibited similar cytotoxicity after DU exposure compared to wild-type (AA8) and XRCC3-complemented (1SFwt8) cells, but DU induced more break-type and fusion-type lesions in XRCC3-deficient cells compared to wild-type and XRCC3-complemented cells. Surprisingly, loss of RAD51D did not affect DU-induced cytotoxicity or genotoxicity. DU induced selective X-chromosome fragmentation irrespective of RAD51D status, but loss of XRCC3 nearly eliminated fragmentation observed after DU exposure in wild-type and XRCC3-complemented cells. Thus, XRCC3, but not RAD51D, protects cells from DU-induced breaks and fusions and also plays a role in DU-induced chromosome fragmentation. Copyright © 2014 Elsevier B.V. All rights reserved.

Measuring Aerosols Generated Inside Armoured Vehicles Perforated by Depleted Uranium Ammunition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parkhurst, MaryAnn

2003-01-01

In response to questions raised after the Gulf War about the health significance of exposure to depleted uranium (DU), the U.S. Department of Defense initiated a study designed to provide an improved scientific basis for assessment of possible health effects of soldiers in vehicles struck by these munitions. As part of this study, a series of DU penetrators were fired at an Abrams tank and a Bradley fighting vehicle, and the aerosols generated by vehicle perforation were collected and characterized. A robust sampling system was designed to collect aerosols in this difficult environment and to monitor continuously the sampler flowmore » rates. Interior aerosols collected were analyzed for uranium concentration and particle size distribution as a function of time. They were also analyzed for uranium oxide phases, particle morphology, and dissolution in vitro. These data will provide input for future prospective and retrospective dose and health risk assessments of inhaled or ingested DU aerosols. This paper briefly discusses the target vehicles, firing trajectories, aerosol samplers and instrumentation control systems, and the types of analyses conducted on the samples.« less

Les granitoïdes de la couverture protérozoïque de la bordure nord du craton du Congo (Sud-Est du Cameroun et Sud-Ouest de la République centrafricaine), témoins d'une activité magmatique post-kibarienne à pré-panafricaineGranitoids of the Proterozoic cover of the Congo craton northern edge (South-East of Cameroon and South-West of the Central African Republic), witnesses of a post-Kibarian to pre-Pan-African magmatic activity

NASA Astrophysics Data System (ADS)

Vicat, Jean-Paul; Moloto-A-Kenguemba, Gaétan; Pouclet, André

2001-02-01

Granitoid bodies dated from the Late Mesoproterozoic intrude the Palaeoproterozoic cover of the northern edge of the Congo craton. They line up a north-south left-lateral shear zone related to the Late Kibaran tectonics. They originated from crustal melting, may be due to the thermal anomalies, that were responsible of the large basaltic production during the pre-Pan-African extension of the Central Africa rift system.

Consequences experimentales des effets des fluctuations du vide sur la fluorescence parametrique et la generation du second harmonique en milieu confine

NASA Astrophysics Data System (ADS)

Robichaud, Luc

Les fluctuations du vide, qui consistent en l'apparition momentanee de particules, ce qui est permit par le principe d'incertitude de Heisenberg, joue un role primordial dans les processus photoniques, en particulier les processus non-lineaires. Par la manipulation de ces fluctuations du vide a l'aide de confinement optique, on retrouve deux phenomenes particuliers : l'intensification de la fluorescence parametrique (Walker, 2008) et l'inhibition de la generation du second harmonique (Collette, 2013). Dans ce travail, on presente les resultats dans le cas classique ; c'est-a-dire sans fluctuations du vide et confinement. Par la suite, on presente les effets des fluctuations du vide et du confinement, ce qui mene aux deux effets mentionnes. Dans le cas de la fluorescence parametrique, le bruit quantique sur le champ interne et externe est calcule, le role du desaccord de phase dans le modele est expose et une generalisation tridimensionnelle est etudiee afin de generaliser la conception du modele d'un cas unidimensionnel a un cas tridimensionnel planaire. Dans le cas de la generation du second harmonique, les difficultes d'un modele purement tridimensionnel sont exposees et ensuite le cas limite planaire est etudie.

Grades and Incentives: Assessing Competing Grade Point Average Measures and Postgraduate Outcomes

ERIC Educational Resources Information Center

Bailey, Michael A.; Rosenthal, Jeffrey S.; Yoon, Albert H.

2016-01-01

In many educational settings, students may have an incentive to take courses where high grades are easier to achieve, potentially corroding student learning, evaluation of student achievement, and the fairness and efficiency of post-graduation labor outcomes. A grading system that takes into account heterogeneity of teacher standards and student…

Dysfonctionnements radio-induits du transport colique chez le rat

NASA Astrophysics Data System (ADS)

François, A.; Lebrun, F.; Ksas, B.; Aigueperse, J.; Gourmelon, P.; MacNaughton, W. K.; Griffiths, N. M.

1998-04-01

The symptom commonly associated with whole body irradiation is diarrhoea, a still quite obscure phenomenon, which leads to decreased chance of cure of irradiated people. The aim of this study was to provide evidence for dysfunction of intestinal water and electrolyte transport regulation by the enteric nervous system after exposure to ionising radiation. This study shows decreased capacity of enteric nervous system to influence colonic transport 3days after irradiation, correlated to a diminished response to a neurotransmitter: serotonin. Radio-induced diarrhea may result from epithelial structural injury but also from impaired regulatory processes of intestinal transport. L'un des symptômes majeurs d'une irradiation corporelle totale ou abdominale est l'apparition de diarrhées, dont les causes sont encore mal connues, et qui mettent en jeu le pronostique vital de l'individu irradié. Cette étude vise à mettre en évidence l'atteinte de la régulation du transport intestinal d'eau et d'électrolytes par les rayonnements ionisants. On observe une diminution de la capacité du système nerveux entérique à influencer le transport colique 3jours après irradiation, corrélée à une diminution de la réponse épithéliale à un neurotransmetteur : la sérotonine. Les diarrhées radio-induites résulteraient d'une atteinte structurelle de l'épithélium mais également des processus de régulation du transport intestinal.

An alternative for cost-effective remediation of depleted uranium (DU) at certain environmental restoration sites.

PubMed

Miller, M; Galloway, B; VanDerpoel, G; Johnson, E; Copland, J; Salazar, M

2000-02-01

Numerous sites in the United States and around the world are contaminated with depleted uranium (DU) in various forms. A prevalent form is fragmented DU originating from various scientific tests involving high explosives and DU during weapon development programs, at firing practice ranges, or war theaters where DU was used in armor-piercing projectiles. The contamination at these sites is typically very heterogeneous, with discreet, visually identifiable DU fragments mixed with native soil. That is, the bulk-averaged DU activity is quite low, while specific DU fragments, which are distinct from the soil matrix, have much higher specific activity. DU is best known as a dark, black metal that is nearly twice as dense as lead, but DU in the environment readily weathers (oxidizes) to a distinctive bright yellow color that is readily visible. While the specific activity (amount of radioactivity per mass of soil) of DU is relatively low and presents only a minor radiological hazard, the fact that it is radioactive and visually identifiable makes it desirable to remove the DU "contamination" from the environment. The typical approach to conducting this DU remediation is to use radiation detection instruments to identify the contaminant and separate it from the adjacent soil, packaging it for disposal as radioactive waste. This process can be performed manually or by specialized, automated equipment. Alternatively, in certain situations a more cost-effective approach might be simple mechanical or gravimetric separation of the DU fragments from the host soil matrix. At SNL/NM, both the automated and simple mechanical approaches have recently been employed. This paper discusses the pros/cons of the two approaches.

[Intravenous chemotherapy at home: A pediatric monocentric experience].

PubMed

Bertrand, Amandine; Favier, Bertrand; Devaux, Yves; Goy, Florence; Marcault-Derouard, Anna; Veyet, Véronique; Cervos, Marie; Schell, Matthias

2018-02-01

Our home care unit (HCU) developed the administration of IV chemotherapy at home for some pediatric oncologic patients. We conducted a retrospective monocentric analysis, leading to identify patients with at least one sequence of chemotherapy at home in 2015. Two hundred and forty four sequences of home chemotherapy have been administered in 2015. We identified two situations for home IV chemotherapy. Pediatric oncologist of day hospital prescribes the sequence. The chemotherapy is delivered at hospital for the first day. HCU takes over for the next days at home. For a sequence replacing a conventional hospitalization, the attending physician examines the patient, and confirm the clinical validation. The pediatric oncologist of HCU checks lab exams, and prescribes the chemotherapy. For both situations, IV chemotherapy is prepared by our hospital pharmacy, delivers at home or at day hospital, and HCU team manages home material and organizes hospitalization. This kind of organization allows setting up home IV CT for more and more patients. It allows to limit daily hospitalization for some patients living far from the hospital, and whose therapies lead to several hospitalizations. Copyright © 2017 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Cirque du Monde en tant qu’intervention en santé

PubMed Central

Fournier, Cynthia; Drouin, Mélodie-Anne; Marcoux, Jérémie; Garel, Patricia; Bochud, Emmanuel; Théberge, Julie; Aubertin, Patrice; Favreau, Gil; Fleet, Richard

2014-01-01

Résumé Objectif Présenter le programme Cirque du Monde du Cirque du Soleil et son potentiel en tant qu’intervention en soins de santé de première ligne pour les médecins de famille. Sources des données Une revue de la littérature menée dans les bases de données PubMed, Cochrane Library, PsycINFO, La Presse, Eureka, Google Scholar et Érudit à l’aide des mots-clés circus, social circus, Cirque du Monde et Cirque du Soleil. Une initiative à Montréal nommée Espace Transition qui s’inspire directement de Cirque du Monde. Communication personnelle avec le conseiller principal en formation en cirque social du Cirque du Soleil. Sélection d’études Les 50 premiers articles ou sites Internet répertoriés pour chaque mot-clé dans chacune des bases de données ciblées ont été révisés sur la base des titres et des résumés, s’il s’agissait d’un article, ou sur la base du titre et du contenu de la page, s’il s’agissait d’une page Internet. Ensuite, les articles et les sites Internet qui étudiaient un aspect du cirque social ou qui présentaient une intervention impliquant le cirque étaient retenus pour une révision. Aucune contrainte d’année de publication n’a été appliquée étant donné qu’on cherchait une littérature générale sur le cirque social. Synthèse Aucun article n’a été trouvé sur le cirque social en tant qu’intervention en santé. Nous avons trouvé une étude sur l’utilisation du cirque en tant qu’intervention en milieu scolaire. Cette étude a démontré une augmentation de l’estime personnelle des enfants grâce à l’intervention. Nous avons trouvé une étude sur l’utilisation du cirque en tant qu’intervention sur une réserve amérindienne. Cette étude présente des résultats qualitatifs non spécifiques au programme du cirque social. Les autres articles répertoriés n’étaient que des descriptions du cirque social. Un site web concernant l’utilisation du cirque social pour faciliter la réintégration sociale de jeunes traités en milieu hospitalier pour un trouble psychiatrique majeur a été répertorié. L’équipe du département de pédopsychiatrie du Centre hospitalier universitaire Sainte-Justine responsable de ce projet nommé Espace Transition a été contactée. Des résultats préliminaires non publiés du projet pilote montrent des améliorations significatives du fonctionnement général des patients. Selon le Cirque du Soleil, plusieurs projets de recherche portant sur l’impact thérapeutique du cirque social sont en cours à travers le monde. Conclusion Cirque du Monde rejoint une clientèle marginalisée difficilement accessible par le système de santé. Ce programme revêt un potentiel thérapeutique de par sa clientèle cible, sa promotion de saines habitudes de vie et le soutien qu’il offre par l’intermédiaire du groupe et des intervenants. Compte tenu des investissements financiers importants du Cirque du Soleil dans ce projet, le manque de littérature donnant accès à des données probantes constitue un enjeu important.

Setting standards for the future

DOT National Transportation Integrated Search

1993-12-01

Traffic management systems, such as metering lights, ramp signals and stop signs and lights, have been in use for so many years that drivers now take them for granted. The planned introduction of Advanced Traffic Management Systems (ATMS) will ...

Depleted uranium contamination by inhalation exposure and its detection after approximately 20 years: implications for human health assessment.

PubMed

Parrish, Randall R; Horstwood, Matthew; Arnason, John G; Chenery, Simon; Brewer, Tim; Lloyd, Nicholas S; Carpenter, David O

2008-02-01

Inhaled depleted uranium (DU) aerosols are recognised as a distinct human health hazard and DU has been suggested to be responsible in part for illness in both military and civilian populations that may have been exposed. This study aimed to develop and use a testing procedure capable of detecting an individual's historic milligram-quantity aerosol exposure to DU up to 20 years after the event. This method was applied to individuals associated with or living proximal to a DU munitions plant in Colonie New York that were likely to have had a significant DU aerosol inhalation exposure, in order to improve DU-exposure screening reliability and gain insight into the residence time of DU in humans. We show using sensitive mass spectrometric techniques that when exposure to aerosol has been unambiguous and in sufficient quantity, urinary excretion of DU can be detected more than 20 years after primary DU inhalation contamination ceased, even when DU constitutes only approximately 1% of the total excreted uranium. It seems reasonable to conclude that a chronically DU-exposed population exists within the contamination 'footprint' of the munitions plant in Colonie, New York. The method allows even a modest DU exposure to be identified where other less sensitive methods would have failed entirely. This should allow better assessment of historical exposure incidence than currently exists.

Approche de prise en charge du trouble du spectre de l’autisme

PubMed Central

Lee, Patrick F.; Thomas, Roger E.; Lee, Patricia A.

2015-01-01

Résumé Objectif Se pencher sur les critères diagnostiques du trouble du spectre de l’autisme (TSA) comme les définit le Manuel diagnostique et statistique des troubles mentaux, cinquième édition (DSM-V), et concevoir une approche de prise en charge du TSA à l’aide du cadre CanMEDS–Médecine familiale (CanMEDS-MF). Sources d’information Le DSM-V, publié par l’American Psychiatric Association en mai 2013, énonce de nouveaux critères diagnostiques du TSA. Le cadre CanMEDS-MF du Collège des médecins de famille du Canada fournit un plan d’orientation pour la prise en charge complexe du TSA. Nous avons utilisé des données recueillies par le Centers for Disease Control and Prevention afin de déterminer la prévalence du TSA, ainsi que la revue systématique et méta-analyse détaillée effectuée par le National Institute for Health and Care Excellence du R.-U. pour ses lignes directrices sur le TSA dans le but d’évaluer les données probantes issues de plus de 100 interventions. Message principal Selon les données du Centers for Disease Control and Prevention, la prévalence du TSA se chiffrait à 1 sur 88 en 2008 aux États-Unis. La classification du TSA dans la quatrième édition du DSM incluait l’autisme, le syndrome d’Asperger, le trouble envahissant du développement et le trouble désintégratif de l’enfance. La dernière révision du DSM-V réunit tous ces troubles sous la mention TSA, avec différents niveaux de sévérité. La prise en charge du TSA est complexe; elle exige les efforts d’une équipe multidisciplinaire ainsi que des soins continus. Les rôles CanMEDS-MF fournissent un cadre de prise en charge. Conclusion Les médecins de famille sont au cœur de l’équipe de soins multidisciplinaire pour le TSA, et le cadre CanMEDS-MF tient lieu de plan détaillé pour guider la prise en charge d’un enfant atteint de TSA et aider la famille de cet enfant.

Nouvelles approches en theorie du champ moyen dynamique: le cas du pouvoir thermoelectrique et celui de l'effet orbital d'un champ magnetique

NASA Astrophysics Data System (ADS)

Arsenault, Louis-Francois

Les applications reliees a la generation d'energie motivent la recherche de materiaux ayant un fort pouvoir thermoelectrique (S). De plus, S nous renseigne sur certaines proprietes fondamentales des materiaux, comme, par exemple, la transition entre l'etat coherent et incoherent des quasi-particules lorsque la temperature augmente. Empiriquement, la presence de fortes interactions electron-electron peut mener a un pouvoir thermoelectrique geant. Nous avons donc etudie le modele le plus simple qui tient compte de ces fortes interactions, le modele de Hubbard. La theorie du champ moyen dynamique (DMFT) est tout indiquee dans ce cas. Nous nous sommes concentres sur un systeme tridimensionnel (3d) cubique a face centree (fcc), et ce, pour plusieurs raisons. A) Ce type de cristal est tres commun dans la nature. B) La DMFT donne de tres bons resultats en 3d et donc ce choix sert aussi de preuve de principe de la methode. C) Finalement, a cause de la frustration electronique intrinseque au fcc, celui-ci ne presente pas de symetrie particule-trou, ce qui est tres favorable a l'apparition d'une grande valeur de S. Ce travail demontre que lorsque le materiau est un isolant a demi-remplissage a cause des fortes interactions (isolant de Mott), il est possible d'obtenir de grands pouvoirs thermoelectriques en le dopant legerement. C'est un resultat pratique important. Du point de vue methodologique, nous avons montre comment la limite de frequence infinie de S et l'approche dite de Kelvin, qui considere la limite de frequence nulle avant la limite thermodynamique pour S, donnent des estimations fiables de la vraie limite continue (DC) dans les domaines de temperature appropriee. Ces deux approches facilitent grandement les calculs en court-circuit ant la necessite de recourir a de problematiques prolongements analytiques. Nous avons trouve que la methode de calcul a frequence infinie fonctionne bien lorsque les echelles d'energie sont relativement faibles. En d'autres termes, cette approche donne une bonne representation de S lorsque le systeme devient coherent. Les calculs montrent aussi que la formule Kelvin est precise lorsque la fonction spectrale des electrons devient incoherente, soit a plus haute temperature. Dans la limite Kelvin, S est essentiellement l'entropie par particule, tel que propose il y a longtemps. Nos resultats demontrent ainsi que la vision purement entropique de S est la bonne dans le regime incoherent, alors que dans le regime coherent, l'approche a frequence infinie est meilleure. Nous avons utilise une methode a la fine pointe, soit le Monte-Carlo quantique en temps continu pour resoudre la DMFT. Pour permettre une exploration rapide du diagramme de phase, nous avons du developper une nouvelle version de la methode des perturbations iterees pour qu'elle soit applicable aussi a forte interaction au-dela de la valeur critique de la transition de Mott. Un autre sujet a aussi ete aborde. L'effet orbital du champ magnetique dans les systemes electroniques fortement correles est une question tres importante et peu developpee. Cela est d'autant plus essentiel depuis la decouverte des oscillations quantiques dans les supraconducteurs a haute temperature (haut- Tc). Par desir de developper une methode la moins biaisee possible, nous avons derive la DMFT lorsqu'un champ se couplant a l'operateur energie cinetique par la substitution de Peierls est present. Ce type d'approche est necessaire pour comprendre entre autres l'effet de la physique de Mott sur des phenomenes tels que les oscillations quantiques. Nous avons obtenu un resultat tres important en demontrant rigoureusement que la relation d'auto-coherence de la DMFT et le systeme intermediaire d'impurete quantique restent les memes. L'effet du champ peut etre contenu dans la fonction de Green locale, ce qui constitue la grande difference avec le cas habituel. Ceci permet de continuer a utiliser les solutionneurs d'impuretes standards, qui sont de plus en plus puissants. Nous avons aussi developpe la methode pour le cas d'un empilement de plans bidimensionnels selon z, ce qui permet d'etudier l'effet orbital du champ dans des nanostructures et meme dans les materiaux massifs, si le nombre de plans est suffisant pour obtenir la limite tridimensionnelle. Mots cles : Pouvoir thermoelectrique, Theorie du Champ Moyen Dynamique, Modele de Hubbard, Effet orbital du champ magnetique, Electrons fortement correles, Materiaux quantiques, Theorie des perturbations iterees

USSR Report, Human Resources, No. 99.

DTIC Science & Technology

1983-11-10

of management for the system "man—production." Here, of course, much still remains to be done. Take, for example, improvement of norm setting of...setting of the labor outlays of primary and ancil- lary operations, development of criteria of occupational abilities and creation of optimal principles

Methodology for Assessing Disruptions (MAD) Game Part I: Report and Analysis

DTIC Science & Technology

2012-12-01

élaborées dans le Guide de planification fonctionnelle du groupe du SMA(S& T ). Le présent mémorandum technique est principalement destiné au Bureau du...le Guide de planification fonctionnelle du groupe du SMA(S& T ). Le présent mémorandum technique est principalement destiné au Bureau du scientifique en...2010 2012-009 Principal Author Original signed by G . Adlakha-Hutcheon, M. Hazen, P. Hubbard, S. McLelland, K. Sprague G . Adlakha

A 400-year phytolith-based reconstruction of wild rice (Zizania palustris) abundance from Mud Lake core sediments, Fond du Lac Band of Lake Superior Chippewa Reservation, Minnesota, USA.

NASA Astrophysics Data System (ADS)

Munoz, R.; Caylor, E.; Yost, C. L.; Drake, C.; Ladwig, J. L.; Myrbo, A.; Howes, T.

2014-12-01

Wild rice (Zizania palustris L.) is an aquatic grass with spiritual and subsistence significance to Native people of the Great Lakes region of North America. Mud Lake (Mashkiigwaagamaag), located on the Fond du Lac Band of Lake Superior Chippewa Reservation in Carlton County, Minnesota, USA, once supported an extensive population of wild rice (manoomin). However, early 20th century attempts to ditch and drain surrounding wetlands for landuse intensification severely altered the natural hydrological system that supports wild rice. Fond du Lac Resource Management (FDLRM) technicians are currently working to increase the wild rice population in Mud Lake. As part of these efforts, this phytolith study was undertaken to better understand how wild rice abundance has fluctuated over the past 400 years, with particular emphasis on the 19th and 20th centuries. Phytoliths are microscopic opal silica plant remains that are incorporated into soils and lake sediments after the plant-parts that contain them decay. Wild rice produces phytolith morphotypes that are unequivocally diagnostic. Mud Lake core MNMN-MUD11-1C-1P-1 (46°43'38.39"N, 92°42'2.45"W) was piston cored by LacCore (National Lacustrine Core Facility) and FDLRM technicians on 24 May 2011. Initial core descriptions, multi-sensor core logging, phytolith sampling and phytolith extractions were completed during the summer of 2014 at LacCore. Wild rice phytolith identification and quantification was conducted on twelve samples using brightfield microscopy at 400x magnification. Wild rice phytolith concentration values ranged from 68 to 2,300 phytoliths/cm3. Wild rice accumulation rates ranged from 9 to 383 phytoliths/ cm2/yr, peaking in 1952 AD. Wild rice abundance in Mud Lake appears to be influenced by a complex set of variables that include anthropogenic disturbance, climatic events and aquatic plant community succession.

The research on electronic commerce security payment system based on set protocol

NASA Astrophysics Data System (ADS)

Guo, Hongliang

2012-04-01

With the rapid development of network technology, online transactions have become more and more common. In this paper, we firstly introduce the principle and the basic principal and technical foundation of SET, and then we analyze the progress of designing a system in the foundation of the procedure of the electronic business based on SET. On this basis, we design a system of the Payment System for Electronic Business. It will not only take on crucial realism signification for large-scale, medium-sized and mini-type corporations, but also provide guide meaning with programmer and design-developer to realize Electronic Commerce (EC).

Participation des médecins généralistes de la province de Benimellal (Maroc) dans le dépistage du cancer du col

PubMed Central

Nani, Samira; Benallal, Mohamed; Hassoune, Samira; Kissi, Dounia; Maaroufi, Abderrahmane

2013-01-01

Introduction Au Maroc, chaque année il y aurait environ 2000 nouveaux cas de cancer du col et les 2/3 des cas sont pris en charge à un stade très avancé. Nous avons mené une étude transversale, exhaustive incluant les 71 médecins généralistes exerçant dans les établissements de soins de santé de base du secteur public et privé de la province de Benimellal. Le but était d’évaluer leurs connaissances et leur participation au dépistage du cancer du col. Méthodes Nous avons mené une étude transversale, exhaustive incluant les 71 médecins généralistes exerçant dans les établissements de soins de santé de base du secteur public et privé de la province de Benimellal. Le but était d’évaluer leurs connaissances et leur participation au dépistage du cancer du col. Résultats Le niveau de connaissance était relativement modeste, 22 médecins généraliste avaient répondu à la question sur l'incidence du cancer du col au Maroc, Parmi eux (81,8%) avaient donné une réponse incorrecte. L'Herpes Papilloma virus comme facteur de risque du cancer du col a été identifié par seulement 21% des médecins généralistes. La participation au dépistage était également défaillante, 92,8% n'avaient jamais pratiqué le FCV chez leurs patientes à cause principalement du manque de formation (95,5%). Conclusion Les résultats montrent la nécessité d'améliorer les connaissances théoriques et pratique des médecins généralistes concernant le dépistage du cancer du col. PMID:23785557

A Review of Depleted Uranium Biological Effects: In vivo Studies

DTIC Science & Technology

2010-11-01

organs - Uranium retention is long-term - DU causes some neurotoxicity - DU induces genotoxicity - DU urine is mutagenic - DU causes adverse oncogene...Behavior; Locomotor Brain Accumulation Sperm Effects Immune Effects Offspring Effects Behavior Yes Yes Yes No effects Decreased Inflammatory...in Unexposed Offspring Finding: DU Internalized Exposure Induces Germ Cell DNA Damage Uranium Distribution Behavior Neurobio Histopathology Sperm

[Sport coaching for psychological and social recovery after hematological cancer: An innovative perspective].

PubMed

Calvin, Sarah; Blaise, Didier; Ben Soussan, Patrick; Cuvelier, Sarah; Cicut, Nicolas; Caymaris, Laurence; Arnault, Yolande; Onesta, Claude; Dantin, Pierre; Viens, Patrice

2017-10-01

This study is a first step towards the transfer of knowledge and practices between psychological support and performance in elite sport and a patient's "social recovery" in oncology. This proposal brings together people engaged in a variety of healthcare and relationship support roles, and aims to set up a support system beyond the hospital context. It questions the ability of elite sport management and its main actors, the "Great Coaches", to contribute to the support of patients in cancer remission through an onco-coaching approach. This innovative proposal is initiated by a life coaching pilot study designed for hematologic cancer patients in remission after a hematopoietic stem cell transplantation. Copyright © 2017 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

L'ilot du reservoir: etude de voisinage en milieu urbain (The Reservoir Block: A Study of a Neighborhood in an Urban Setting).

ERIC Educational Resources Information Center

Rey, Jean-Noel

1983-01-01

An analysis of a small neighborhood of Paris looks at its layout and spatial constraints, habitats, symbols, sense of territory, and rhythms and styles of the inhabitants and their roles in the group. The description, including photos, is intended for use in the French language classroom. (MSE)

Reduction of astrographic catalogues

NASA Technical Reports Server (NTRS)

Stock, J.; Prugna, F. D.; Cova, J.

1984-01-01

An automatic program for the reduction of overlapping Carte du Ciel plates is described. The projection and transformation equations are given and the RAA subprogram flow is outlined. The program was applied to two different sets of data, namely to nine overlapping plates of the Cape Zone of the CdC, and to fifteen plates taken with the CIDA-refractor of the open cluster Tr10.

Non-destructive analysis of DU content in the NIF hohlraums

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gharibyan, Narek; Moody, Ken J.; Shaughnessy, Dawn A.

2015-12-16

The advantage of using depleted uranium (DU) hohlraums in high-yield deuterium-tritium (DT) shots at the National Ignition Facility (NIF) is addressed by Döppner, et al., in great detail [1]. This DU based hohlraum incorporates a thin layer of DU, ~7 μm thick, on the inner surface along with a thin layer of a gold coating, ~0.7 μm thick, while the outer layer is ~22 μm thick gold. A thickness measurement of the DU layer can be performed using an optical microscope where the total DU weight can be computed provided a uniform DU layer. However, the uniformity of the thicknessmore » is not constant throughout the hohlraum since CAD drawing calculations of the DU weight do not agree with the computed values from optical measurements [2]. Therefore, a non-destructive method for quantifying the DU content in hohlraums has been established by utilizing gamma-ray spectroscopy. The details of this method, along with results from several hohlraums, are presented in this report.« less

Reconstruction de la surface de Fermi dans l'etat normal d'un supraconducteur a haute Tc: Une etude du transport electrique en champ magnetique intense

NASA Astrophysics Data System (ADS)

Le Boeuf, David

Des mesures de resistance longitudinale et de resistance de Hall en champ magnetique intense transverse (perpendiculaire aux plans CuO2) ont ete effectuees au sein de monocristaux de YBa2Cu3Oy (YBCO) demacles, ordonnes et de grande purete, afin d'etudier l'etat fondamental des supraconducteurs a haute Tc dans le regime sous-dope. Cette etude a ete realisee en fonction du dopage et de l'orientation du courant d'excitation J par rapport a l'axe orthorhombique b de la structure cristalline. Les mesures en champ magnetique intense revelent par suppression de la supraconductivite des oscillations magnetiques des resistances longitudinale et de Hall dans YBa2Cu 3O6.51 et YBa2Cu4O8. La conformite du comportement de ces oscillations quantiques au formalisme de Lifshitz-Kosevich, apporte la preuve de l'existence d'une surface de Fermi fermee a caractere quasi-2D, abritant des quasiparticules coherentes respectant la statistique de Fermi-Dirac, dans la phase pseudogap d'YBCO. La faible frequence des oscillations quantiques, combinee avec l'etude de la partie monotone de la resistance de Hall en fonction de la temperature indique que la surface de Fermi d'YBCO sous-dope comprend une petite poche de Fermi occupee par des porteurs de charge negative. Cette particularite de la surface de Fermi dans le regime sous-dope incompatible avec les calculs de structure de bande est en fort contraste avec la structure electronique presente dans le regime surdope. Cette observation implique ainsi l'existence d'un point critique quantique dans le diagramme de phase d'YBCO, au voisinage duquel la surface de Fermi doit subir une reconstruction induite par l'etablissement d'une brisure de la symetrie de translation du reseau cristallin sous-jacent. Enfin, l'etude en fonction du dopage de la resistance de Hall et de la resistance longitudinale en champ magnetique intense suggere qu'un ordre du type onde de densite (DW) est responsable de la reconstruction de la surface de Fermi. L'analogie de la phenomenologie entourant le comportement des resistances longitudinale et de Hall dans YBa2Cu3Oy, avec des systemes dans lesquels l'existence d'un ordre du type DW est etablie, notamment des cuprates a structure tetragonale a basse temperature ("Low Temperature Tetragonal", LTT), indique que l'ordre causant la reconstruction de la surface de Fermi est stabilise au voisinage du dopage p = 1/8, et est en competition directe avec la supraconductivite.

DuOCam: A Two-Channel Camera for Simultaneous Photometric Observations of Stellar Clusters

NASA Astrophysics Data System (ADS)

Maier, Erin R.; Witt, Emily; Depoy, Darren L.; Schmidt, Luke M.

2017-01-01

We have designed the Dual Observation Camera (DuOCam), which uses commercial, off-the-shelf optics to perform simultaneous photometric observations of astronomical objects at red and blue wavelengths. Collected light enters DuOCam’s optical assembly, where it is collimated by a negative doublet lens. It is then separated by a 45 degree blue dichroic filter (transmission bandpass: 530 - 800 nm, reflection bandpass: 400 - 475 nm). Finally, the separated light is focused by two identical positive doublet lenses onto two independent charge-coupled devices (CCDs), the SBIG ST-8300M and the SBIG STF-8300M. This optical assembly converts the observing telescope to an f/11 system, which balances maximum field of view with optimum focus. DuOCam was commissioned on the McDonald Observatory 0.9m, f/13.5 telescope from July 21st - 24th, 2016. Observations of three globular and three open stellar clusters were carried out. The resulting data were used to construct R vs. B-R color magnitude diagrams for a selection of the observed clusters. The diagrams display the characteristic evolutionary track for a stellar cluster, including the main sequence and main sequence turn-off.

Metallographic Characterization of Wrought Depleted Uranium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forsyth, Robert Thomas; Hill, Mary Ann

Metallographic characterization was performed on wrought depleted uranium (DU) samples taken from the longitudinal and transverse orientations from specific locations on two specimens. Characterization of the samples included general microstructure, inclusion analysis, grain size analysis, and microhardness testing. Comparisons of the characterization results were made to determine any differences based on specimen, sample orientation, or sample location. In addition, the characterization results for the wrought DU samples were also compared with data obtained from the metallographic characterization of cast DU samples previously characterized. No differences were observed in microstructure, inclusion size, morphology, and distribution, or grain size in regard tomore » specimen, location, or orientation for the wrought depleted uranium samples. However, a small difference was observed in average hardness with regard to orientation at the same locations within the same specimen. The longitudinal samples were slightly harder than the transverse samples from the same location of the same specimen. This was true for both wrought DU specimens. Comparing the wrought DU sample data with the previously characterized cast DU sample data, distinct differences in microstructure, inclusion size, morphology and distribution, grain size, and microhardness were observed. As expected, the microstructure of the wrought DU samples consisted of small recrystallized grains which were uniform, randomly oriented, and equiaxed with minimal twinning observed in only a few grains. In contrast, the cast DU microstructure consisted of large irregularly shaped grains with extensive twinning observed in most grains. Inclusions in the wrought DU samples were elongated, broken and cracked and light and dark phases were observed in some inclusions. The mean inclusion area percentage for the wrought DU samples ranged from 0.08% to 0.34% and the average density from all wrought DU samples was 1.62E+04/cm 2. Inclusions in the cast DU samples were equiaxed and intact with light and dark phases observed in some inclusions. The mean inclusion area percentage for the cast DU samples ranged from 0.93% to 1.00% and the average density from all wrought DU samples was 2.83E+04/cm 2. The average mean grain area from all wrought DU samples was 141 μm 2 while the average mean grain area from all cast DU samples was 1.7 mm2. The average Knoop microhardness from all wrought DU samples was 215 HK and the average Knoop microhardness from all cast DU samples was 264 HK.« less

Searching for the Beginning of the Ozone Turnaround Using a 22-Year Merged Satellite Data Set

NASA Technical Reports Server (NTRS)

Stolarski, Richard S.; Meeson, Blanche W. (Technical Monitor)

2001-01-01

We have used the data from six satellite instruments that measure the total column amount of ozone to construct a consistent merged data set extending from late 1978 into 2000. The keys to constructing a merged data set are to minimize potential drift of individual instruments and to accurately establish instrument-to-instrument offsets. We have used the short-wavelength D-pair measurements (306nm-313nm) of the SBUV and SBUV/2 instruments near the equator to establish a relatively drift-free record for these instruments. We have then used their overlap with the Nimbus 7 and EP TOMS instruments to establish the relative calibration of the various instruments. We have evaluated the drift uncertainty in our merged ozone data (MOD) set by examining both the individual instrument drift uncertainty and the uncertainty in establishing the instrument- to-instrument differences. We conclude that the instrumental drift uncertainty over the 22-year data record is 0.9 %/decade (2-sigma). We have compared our MOD record with 37 ground stations that have a continuous record over that time period. We have a mean drift with respect to the stations of +0.3 %/decade which is within 1-sigma of our uncertainty estimate. Using the satellite record as a transfer standard, we can estimate the capability of the ground instruments to establish satellite calibration. Adding the statistical variability of the station drifts with respect to the satellite to an estimate of the overall drift uncertainty of the world standard instrument, we conclude that the stations should be able to be used to establish the drift of the satellite data record to within and uncertainty of 0.6 %/decade (2-sigma). Adding to this an uncertainty due to the-incomplete global coverage of the stations, we conclude that the station data should be able to establish the global trend with an uncertainty of about 0.7 %/decade, slightly better than for the satellite record. We conclude that merging the two records together gives only a slight improvement in the uncertainty. Keeping them separate gives the greater confidence of two independent measures of the ozone trend and potential recovery. We fit the trend in our MOD record through May of 1991 and then extrapolated forward to see if the data at the end of the record was above the statistical model as a measure of ozone recovery as was done in the last WMO/UNEP assessment report. Because our data set drifts with respect to the ground-stations through May of 1991, we calculated a smaller global trend (-1.1 %/decade) than in the WMO/UNEP report. Our data in 1998 and 1999 was, on average 2 DU above the extrapolated statistical model with a 2-sigma uncertainty of 6 DU. For the combined mid-latitudes of the northern and southern hemispheres, the data was 5 DU above the extrapolated statistical model with a 2-sigma uncertainty of 10 DU. These may be signs of recovery, but they are still statistically insignificant.

A pro-am collaboration to use the 1 meter telescope at Pic du Midi observatory in order to follow the evolution of giant planets atmospheres

NASA Astrophysics Data System (ADS)

Dauvergne, J.-L.; Colas, F.; Delcroix, M.; Lecacheux, J.

2017-09-01

Pic du Midi observatory is known for a long time to produce some of the best planetary images. That's the result of a strong collaboration between professionals and amateurs these last 15 years [1]. The technique is still improving, and we even consider the possibility to use an adaptive optic system next year. However without adaptative optic, just with the lucky imagining method, we already have done a lot of publications with the astronomers of Bilbao University.

ACOSS Three (Active Control of Space Structures). Phase I.

DTIC Science & Technology

1980-05-01

their assorted pitfalls, programs such as NASTRAN, SPAR, ASTRO , etc., are never-the-less the primary tools for generating dynamical models of...proofs and additional details, see Ref [*] Consider the system described in state-space form by: Dynamics: X = FX + Gu Sensors: y = HX = (F +GCH)X (1...input u and output y = Fx + Gu (6) y = Hx+Du (7) The input-output transfer function is given by y = (H(sI- F)-1G +D)u (8) or y(s) _ 1 N u(s) A(s) E

Telescope Bernard Lyot: operation, instrumentation, perspectives

NASA Astrophysics Data System (ADS)

Cabanac, R.

2016-12-01

This talk is the TBL director report at the 3rd French national telescopes Users Meeting of 2016. Telescope Bernard Lyot, the 2-m at Pic du midi (2870m), is dedicated to spectro-polarimetric studies since 2007 with the instrument Narval. This paper presents TBL operation, science highlights and statistics of the past 10 years of operation. It also opens perspectives for the coming 10 years with the funding of Neo-Narval (Narval stabilized to v_r < 3m/s) and SPIrou at Pic du midi (aka SPIP) for the study of the young exoplanetary systems.

Geological conditions of safe long-term storage and disposal of depleted uranium hexafluoride

NASA Astrophysics Data System (ADS)

Laverov, N. P.; Velichkin, V. I.; Omel'Yanenko, B. I.; Yudintsev, S. V.; Tagirov, B. R.

2010-08-01

The production of enriched uranium used in nuclear weapons and fuel for atomic power plants is accompanied by the formation of depleted uranium (DU), the amount of which annually increases by 35-40 kt. To date, more than 1.6 Mt DU has accumulated in the world. The main DU mass is stored as environ-mentally hazardous uranium hexafluoride (UF6), which is highly volatile and soluble in water with the formation of hydrofluoric acid. To ensure safe UF6 storage, it is necessary to convert this compound in chemically stable phases. The industrial reprocessing of UF6 into U3O8 and HF implemented in France is highly expensive. We substantiate the expediency of long-term storage of depleted uranium hexafluoride in underground repositories localized in limestone. On the basis of geochemical data and thermodynamic calculations, we show that interaction in the steel container-UF6-limestone-groundwater system gives rise to the development of a slightly alkaline reductive medium favorable for chemical reaction with formation of uraninite (UO2) and fluorite (CaF2). The proposed engineering solution not only ensures safe DU storage but also makes it possible to produce uraninite, which can be utilized, if necessary, in fast-neutron reactors. In the course of further investigations aimed at safe maintenance of DU, it is necessary to study the kinetics of conversion of UF6 into stable phases, involving laboratory and field experiments.

Preliminary evaluation of ground-water contamination by coal-tar derivatives, St. Louis Park area, Minnesota

USGS Publications Warehouse

Hult, Marc F.; Schoenberg, Michael

1981-01-01

Operation of a coal-tar distillation and wood preserving plant for 1918-72 in St. Louis Park, Minnesota, resulted in ground-water contamination. This report presents the results of the first year (1979) of an ongoing study. By 1932, water in the Prairie du Chien-Jordan aquifer, the region 's major source of ground water, was contaminated 3,500 feet from the plant. The hydraulic characteristics of the Prairie du Chien-Jordan aquifer , its long contamination history, and fluctuating pumpage combine to creat a complex distribution of coal-tar derivatives observed in the aquifer. The Prairie du Chien-Jordan aquifer underlies the area at depths of 250 to 500 feet and is overlain by two bedrock aquifers (Platteville and St. Peter), two confining beds (Glenwood and basal part of St. Peter), and 70 to 100 feet of glacial drift. Multiaquifer wells in the area have permitted contaminated water from near-surface aquifers to flow downward into the Prairie du Chien-Jordan aquifer. Flow rates of 20 to 150 gallons per minute from the shallower aquifers into the Prairie du Chien-Jordan aquifer were observed in five wells. In the drift, a hydrocarbon fluid phase is moving vertically downward relative to the aqueous phase. Dissolved constituents in the drift and Platteville aquifer, the uppermost bedrock unit over most of the area, have moved at least 4,000 feet. Low-molecular-weight compounds are moving preferentially through the drift and Platteville aquifer system. (USGS)

Existence of evolutionary variational solutions via the calculus of variations

NASA Astrophysics Data System (ADS)

Bögelein, Verena; Duzaar, Frank; Marcellini, Paolo

In this paper we introduce a purely variational approach to time dependent problems, yielding the existence of global parabolic minimizers, that is ∫0T ∫Ω [uṡ∂tφ+f(x,Du)] dx dt⩽∫0T ∫Ω f(x,Du+Dφ) dx dt, whenever T>0 and φ∈C0∞(Ω×(0,T),RN). For the integrand f:Ω×R→[0,∞] we merely assume convexity with respect to the gradient variable and coercivity. These evolutionary variational solutions are obtained as limits of maps depending on space and time minimizing certain convex variational functionals. In the simplest situation, with some growth conditions on f, the method provides the existence of global weak solutions to Cauchy-Dirichlet problems of parabolic systems of the type ∂tu-divDξf(x,Du)=0 in Ω×(0,∞).

The International Science and Politics of Depleted Uranium (Briefing charts)

DTIC Science & Technology

2010-11-01

lied before …” • Cite each other’s websites • Uniqueness: “DU + Anthrax Vaccine + Diet Soda + Flea Collars + Stress = Gulf War Illness • Demand proving...Activist Quotes • “DU was used in Iraq, Soldiers were in Iraq, Soldiers are sick, DU made the soldiers sick” • “DU is more dangerous than natural uranium...1 atom of DU will kill you” • “DU is more dangerous the further you are from the source” • “Depleted uranium is nuclear waste” • “U.S. is using

Connaissances des médecins généralistes de Mohammedia (Maroc) concernant le dépistage du cancer du sein

PubMed Central

Zine, Karima; Nani, Samira; Lahmadi, Imad Ait; Maaroufi, Abderrahmane

2016-01-01

Introduction Le cancer du sein représente un problème de santé publique majeur au Maroc. C'est le premier cancer chez la femme. L'objectif de ce travail était d'évaluer les connaissances des médecins généralistes (MG) en matière de dépistage du cancer du sein dans la préfecture de Mohammedia Maroc. Méthodes Nous avons mené une étude transversale, descriptive, exhaustive incluant les 97 MG exerçant dans les établissements de soins de santé de base du secteur public et privé de la province de Mohammedia. Résultats Le taux de participation était de 87%. L'âge moyen des MG était de 49,6 ± 8,1. Quatre-vingt pour cent (n=55) des MG ont donné une incidence incorrecte, 77,6% (n=85) ont reconnu l'existence d'un plan national de prévention et de contrôle du cancer (PNPCC) au Maroc, et 67,1 des MG ont rapporté l'existence d'un registre du cancer au Maroc. Le secteur d'activité était associé significativement avec les connaissances des MG sur le PNPCC et sur l'existence d'un guide de détection précoce du cancer du sein avec respectivement (p=0,003 et p=0,001). Une association significative entre l'ancienneté et l'existence d'un guide de détection précoce du cancer du sein et d'un registre du cancer du sein a été retrouvée avec (respectivement p=0,005 et p=0.002). Conclusion À la lumière de ces résultats il faudra renforcer les connaissances et les pratiques des MG par la promotion de la formation initiale et continue sur le dépistage. PMID:27800098

Ghrelin protects against depleted uranium-induced apoptosis of MC3T3-E1 cells through oxidative stress-mediated p38-mitogen-activated protein kinase pathway

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hao, Yuhui; Liu, Cong; Huang, Jiawei

Depleted uranium (DU) mainly accumulates in the bone over the long term. Osteoblast cells are responsible for the formation of bone, and they are sensitive to DU damage. However, studies investigating methods of reducing DU damage in osteoblasts are rarely reported. Ghrelin is a stomach hormone that stimulates growth hormones released from the hypothalamic–pituitary axis, and it is believed to play an important physiological role in bone metabolism. This study evaluates the impact of ghrelin on DU-induced apoptosis of the osteoblast MC3T3-E1 and investigates its underlying mechanisms. The results show that ghrelin relieved the intracellular oxidative stress induced by DU,more » eliminated reactive oxygen species (ROS) and reduced lipid peroxidation by increasing intracellular GSH levels; in addition, ghrelin effectively suppressed apoptosis, enhanced mitochondrial membrane potential, and inhibited cytochrome c release and caspase-3 activation after DU exposure. Moreover, ghrelin significantly reduced the expression of DU-induced phosphorylated p38-mitogen-activated protein kinase (MAPK). A specific inhibitor (SB203580) or specific siRNA of p38-MAPK could significantly suppress DU-induced apoptosis and related signals, whereas ROS production was not affected. In addition, ghrelin receptor inhibition could reduce the anti-apoptosis effect of ghrelin on DU and reverse the effect of ghrelin on intracellular ROS and p38-MAPK after DU exposure. These results suggest that ghrelin can suppress DU-induced apoptosis of MC3T3-E1 cells, reduce DU-induced oxidative stress by interacting with its receptor, and inhibit downstream p38-MAPK activation, thereby suppressing the mitochondrial-dependent apoptosis pathway. - Highlights: • Ghrelin suppressed DU-induced apoptosis of MC3T3-E1 cells. • Ghrelin inhibited DU-induced oxidative stress and further p38-MAPK activation. • Ghrelin further suppressed mitochondrial-dependent apoptosis pathway. • The anti-oxidation effect of ghrelin was regulated through its receptor. • Ghrelin has the potential for use in drug therapies for DU poisoning.« less

Depleted and enriched uranium exposure quantified in former factory workers and local residents of NL Industries, Colonie, NY USA.

PubMed

Arnason, John G; Pellegri, Christine N; Moore, June L; Lewis-Michl, Elizabeth L; Parsons, Patrick J

2016-10-01

Between 1958 and 1982, NL Industries manufactured components of enriched (EU) and depleted uranium (DU) at a factory in Colonie NY, USA. More than 5 metric tons of DU was deposited as microscopic DU oxide particles on the plant site and surrounding residential community. A prior study involving a small number of individuals (n=23) indicated some residents were exposed to DU and former workers to both DU and EU, most probably through inhalation of aerosol particles. Our aim was to measure total uranium [U] and the uranium isotope ratios: (234)U/(238)U; (235)U/(238)U; and (236)U/(238)U, in the urine of a cohort of former workers and nearby residents of the NLI factory, to characterize individual exposure to natural uranium (NU), DU, and EU more than 3 decades after production ceased. We conducted a biomonitoring study in a larger cohort of 32 former workers and 99 residents, who may have been exposed during its period of operation, by measuring Total U, NU, DU, and EU in urine using Sector Field Inductively Coupled Plasma - Mass Spectrometry (SF-ICP-MS). Among workers, 84% were exposed to DU, 9% to EU and DU, and 6% to natural uranium (NU) only. For those exposed to DU, urinary isotopic and [U] compositions result from binary mixing of NU and the DU plant feedstock. Among residents, 8% show evidence of DU exposure, whereas none shows evidence of EU exposure. For residents, the [U] geometric mean is significantly below the value reported for NHANES. There is no significant difference in [U] between exposed and unexposed residents, suggesting that [U] alone is not a reliable indicator of exposure to DU in this group. Ninety four percent of workers tested showed evidence of exposure to DU, EU or both, and were still excreting DU and EU decades after leaving the workforce. The study demonstrates the advantage of measuring multiple isotopic ratios (e.g., (236)U/(238)U and (235)U/(238)U) over a single ratio ((235)U/(238)U) in determining sources of uranium exposure. Copyright © 2016 Elsevier Inc. All rights reserved.

Bonded polyimide fuel cell package

DOEpatents

Morse, Jeffrey D.; Jankowski, Alan; Graff, Robert T.; Bettencourt, Kerry

2010-06-08

Described herein are processes for fabricating microfluidic fuel cell systems with embedded components in which micron-scale features are formed by bonding layers of DuPont Kapton.TM. polyimide laminate. A microfluidic fuel cell system fabricated using this process is also described.

A drive unit for the instrument pointing system

NASA Technical Reports Server (NTRS)

Birner, R.; Roth, M.

1981-01-01

The requirements, capabilities, and unique design features of the instrument pointing system drive units (DU) are presented. The DU's are identical for all three gimbal axes (elevation, cross elevation, and azimuth) and provide alternating rotation of shaft versus the housing of + or - 180 deg. The design features include: two ball bearing cartridges using cemented carbide balls coated with TiC a layer; redundant brushless torque motors and resolvers; a load by-pass mechanism driven by a dc torque motor to off-load the bearings during ascent/descent, ground transportation, and to provide an emergency breaking capability; and cabling over each gimbal axis by means of cable follow-up consisting of 13 signal and 15 power flat band cable loops. Test results of disturbance torque characteristics are presented.

Desiccation of a Sessile Drop of Blood: Cracks Formation and Delamination

NASA Astrophysics Data System (ADS)

Sobac, Benjamin; Brutin, David

2011-11-01

The evaporation of drops of biological fluids has been studied since few years du to several applications in medical fields such as medical tests, drug screening, biostabilization... The evaporation of a drop of whole blood leads to the formation of final typical pattern of cracks. Flow motion, adhesion, gelation and fracturation all occur during the evaporation of this complex matter. During the drying, a sol-gel transition develops. The drying kinetics is explained by a simple model of evaporation taking account of the evolution of the gelation front. The system solidifies and when stresses are too important, cracks nucleate. The cracks formation and the structure of the crack pattern are investigated. The initial crack spacing is found in good agreement with the implementation in open geometry of the model of cracks formation induced by evaporation proposed by Allain and Limat. Finally, the drop is still drying after the end of the formation of cracks which leads, like in the situation of colloid suspensions, to the observation of a delamination phenomenon.

Spreading-vanishing dichotomy in a diffusive logistic model with a free boundary, II

NASA Astrophysics Data System (ADS)

Du, Yihong; Guo, Zongming

We study the diffusive logistic equation with a free boundary in higher space dimensions and heterogeneous environment. Such a model may be used to describe the spreading of a new or invasive species, with the free boundary representing the expanding front. For simplicity, we assume that the environment and the solution are radially symmetric. In the special case of one space dimension and homogeneous environment, this free boundary problem was investigated in Du and Lin (2010) [10]. We prove that the spreading-vanishing dichotomy established in Du and Lin (2010) [10] still holds in the more general and ecologically realistic setting considered here. Moreover, when spreading occurs, we obtain best possible upper and lower bounds for the spreading speed of the expanding front. When the environment is asymptotically homogeneous at infinity, these two bounds coincide. Our results indicate that the asymptotic spreading speed determined by this model does not depend on the spatial dimension.

The Missing Memory of Canadian Sociology: Reflexive Government and "the Social Science".

PubMed

Curtis, Bruce

2016-05-01

The modest literature on the history of Canadian Sociology takes the appearance of a named academic discipline as its object. Canadian Sociology is held to have had some precursors in the 1880s, but really to appear only in the 1920s. It is described as a foreign import and as an activity first of intellectual speculation and moral reform. Observational and analytic practice are absent before 1880. The activities of state agents and government departments in the social field are not discussed. This article offers a richer account through an examination of the larger field from which Sociology was extracted, "the social science," which was practiced actively in colonial Canada from the early nineteenth century. The social science shaped and was itself shaped by colonial conditions. The article outlines three interrelated moments in social science to carry its claims: inventory-making, the emergence of "population-thinking," and "reflexive government." Attending to the social science underlines the complex and convoluted relations of sociology with state power. Les rares oeuvrages académiques portant sur l'histoire de la sociologie canadienne prend pour objet l'apparition du terme dans le contexte universitaire. Dans cet optique, ils signalent certains précurseurs de la sociologie canadienne dès les années 1880, mais en fait ils affirment que cette discipline n'apparaît que dans les années 1920. Cette discipline est présentée comme une importation académique et, d'abord et avant tout, comme de la spéculation intellectuelle et comme un projet de réforme morale. D'après cette vision, les pratiques d'observation et d'analyse sociales ne semblent pas exister avant 1880, et les acteurs politiques et administratifs sont absents du terrain. Notre article propose un examen plus riche du vaste champ duquel la sociologie académique fut arrachée: activement pratiquée au Canada à l'époque coloniale dès le début du XIXe siècle. La science sociale forma et fut formée par les conditions sociales et politiques existant dans la colonie. Notre article expose trois moments pertinents et inter-reliés de la science sociale: la fabrication d'inventaires sociaux; l'émergence du , et l'exercice du . La réintégration de l'histoire de la sociologie canadienne dans la science sociale accentue la relation complexe et incontournable entre sociologie et pouvoir étatique. © 2016 Canadian Sociological Association/La Société canadienne de sociologie.

Depleted and enriched uranium exposure quantified in former factory workers and local residents of NL Industries, Colonie, NY USA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arnason, John G.

Background: Between 1958 and 1982, NL Industries manufactured components of enriched (EU) and depleted uranium (DU) at a factory in Colonie NY, USA. More than 5 metric tons of DU was deposited as microscopic DU oxide particles on the plant site and surrounding residential community. A prior study involving a small number of individuals (n=23) indicated some residents were exposed to DU and former workers to both DU and EU, most probably through inhalation of aerosol particles. Objectives: Our aim was to measure total uranium [U] and the uranium isotope ratios: {sup 234}U/{sup 238}U; {sup 235}U/{sup 238}U; and {sup 236}U/{supmore » 238}U, in the urine of a cohort of former workers and nearby residents of the NLI factory, to characterize individual exposure to natural uranium (NU), DU, and EU more than 3 decades after production ceased. Methods: We conducted a biomonitoring study in a larger cohort of 32 former workers and 99 residents, who may have been exposed during its period of operation, by measuring Total U, NU, DU, and EU in urine using Sector Field Inductively Coupled Plasma - Mass Spectrometry (SF-ICP-MS). Results: Among workers, 84% were exposed to DU, 9% to EU and DU, and 6% to natural uranium (NU) only. For those exposed to DU, urinary isotopic and [U] compositions result from binary mixing of NU and the DU plant feedstock. Among residents, 8% show evidence of DU exposure, whereas none shows evidence of EU exposure. For residents, the [U] geometric mean is significantly below the value reported for NHANES. There is no significant difference in [U] between exposed and unexposed residents, suggesting that [U] alone is not a reliable indicator of exposure to DU in this group. Conclusions: Ninety four percent of workers tested showed evidence of exposure to DU, EU or both, and were still excreting DU and EU decades after leaving the workforce. The study demonstrates the advantage of measuring multiple isotopic ratios (e.g., {sup 236}U/{sup 238}U and {sup 235}U/{sup 238}U) over a single ratio ({sup 235}U/{sup 238}U) in determining sources of uranium exposure. - Highlights: • Biomonitoring study of residents and former workers exposed to DU in Colonie NY. • Urine (99 residents+32 former workers) analyzed for depleted uranium (DU). • DU detected in 84% of workers and 8% of residents >30 years after plant closed. • Enriched uranium detected in 6% of former workers based on isotope ratios.« less

Etude energetique et modelisation d'un Systeme Hybride Eolien-Diesel avec stockage d'Air Comprime (SHEDAC)

NASA Astrophysics Data System (ADS)

Martinez, Nicolas

Actuellement le Canada et plus specialement le Quebec, comptent une multitude de sites isoles dont !'electrification est assuree essentiellement par des generatrices diesel a cause, principalement, de l'eloignement du reseau central de disuibution electrique. Bien que consideree comme une source fiable et continue, 1 'utilisation des generatrices diesel devient de plus en plus problematique d'un point de vue energetique, economique et environnemental. Dans le but d'y resoudre et de proposer une methode d'approvisionnement plus performante, mains onereuse et plus respectueuse de l'environnement, l'usage des energies renouvelables est devenu indispensable. Differents travaux ont alors demontre que le couplage de ces energies avec des generauices diesel, formant des systemes hybrides, semble etre une des meilleures solutions. Parmi elles, le systeme hybride eolien-diesel avec stockage par air comprime (SHEDAC) se presente comme une configuration optimale pour 1 'electrification des sites isoles. En effet, differentes etudes ont permis de mettre en avant l'efficacite du stockage par air comprime, par rapport a d'autres technologies de stockage, en complement d'un systeme hybride eolien-diesel. Plus precisement, ce systeme se compose de sous-systemes qui sont: des eoliennes, des generatrices diesel et une chaine de compression et de stockage d'air comprime qui est ensuite utilisee pour suralimenter les generatrices. Ce processus permet ainsi de reduire Ia consommation en carburant tout en agrandissant la part d'energie renouvelable dans Ia production electrique. A ce jour, divers travaux de recherche ont pennis de demontrer I' efficacite d 'un tel systeme et de presenter une variete de configurations possibles. A travers ce memoire, un logiciel de dimensionnement energetique y est elabore dans le but d'unifom1iser !'approche energetique de cette technologie. Cet outil se veut etre une innovation dans le domaine puisqu'il est actuellement impossible de dimensionner un SHEDAC avec les outils existants. Un etat de l'art specifique associe a une validation des resultats a ete realise dans le but de proposer un logiciel fiable et performant. Dans une logique visant !'implantation d'un SHEDAC sur un site isole du Nord-du-Quebec, le logiciel developpe a ete, ensuite, utilise pour realiser une etude energetique permettant d' en degager la solution optimale a mettre en place. Enfin, a l' aide des outils et des resultats obtenus precedemment, !'elaboration de nouvelles strategies d'operation est presentee dans le but de demontrer comment le systeme pourrait etre optimise afm de repondre a differentes contraintes techniques. Le contenu de ce memoire est presente sous forme de trois articles originaux, soumis a des joumaux scientifiques avec cornite de lecture, et d'un chapitre specifique presentant les nouvelles strategies d 'operation. Ils relatent des travaux decrits dans le paragraphe precedent et permettent d'en deduire un usage concluant et pertinent du SHEDAC dans un site isole nordique.

Neurogenic Causes of Detrusor Underactivity

PubMed Central

Kadow, Brian T.; Tyagi, Pradeep; Chermansky, Christopher J.

2015-01-01

Detrusor underactivity (DU) is a poorly understood dysfunction of the lower urinary tract which arises from multiple etiologies. Symptoms of DU are non-specific, and a pressure-flow urodynamic study is necessary to differentiate DU from other conditions such as overactive bladder (OAB) or bladder outlet obstruction (BOO). The prevalence of DU ranges from 10–48%, and DU is most prevalent in elderly males. The pathophysiology underlying DU can be from both neurogenic and non-neurogenic causes. In this article, we review the neurogenic causes of detrusor underactivity, including diabetic bladder dysfunction, spinal cord injury, multiple sclerosis, Parkinson’s disease, cerebrovascular accident, traumatic brain injury, and Fowler’s syndrome. As knowledge about the underlying causes of DU advances, there have been several potential therapeutic approaches proposed to help those who suffer from this condition. PMID:26715948

Rupture simultanée du ligament croisé antérieur et du ligament patellaire: à propos d'un cas

PubMed Central

Achkoun, Abdessalam; Houjairi, Khalid; Quahtan, Omar; Hassoun, Jalal; Arssi, Mohamed; Rahmi, Mohamed; Garch, Abdelhak

2016-01-01

La rupture simultanée du tendon rotulien et du ligament croisé antérieur est une lésion relativement rare. Son diagnostic peut facilement manquer lors de l'examen initial. Les options de traitement incluent la réparation immédiate du tendon rotulien avec soit la reconstruction simultanée ou différée de ligament croisé antérieur. Nous rapportons le cas d'une rupture combinée du tendon rotulien et du ligament croisé antérieur chez un jeune footballeur de 22 ans. Une approche de traitement en deux temps a été effectuée avec un excellent résultat fonctionnel. PMID:27366288

^1H NMR studies of the diamagnetic gallium (III) and paramagnetic iron (III) complexes of a chiral macrobicyclic ligand of bicapped tris (binaphtol) type

NASA Astrophysics Data System (ADS)

Baret, P.; Beaujolais, V.; Bougault, C.; Gaude, D.; Pierre, J.-L.

1998-01-01

^1H NMR studies of the diamagnetic gallium (III) and paramagnetic iron (III) complexes of a chiral macrobicyclic ligand of bicapped tris (binaphtol) type are described. The study of the gallium complex emphasizes: (i) that the inversion of the octahedral center is not observed and: (ii) the absence of exchange between free ligand and complex, at room temperature. In the case of the iron complex, assignments of the hyperfine shifted resolved resonances are achieved, based on temperature-behavior studies, which evidence the D3 symmetry of the complex. These assignments are in complete agreement with measured T1 values and proton-to-iron distances obtained from molecular modelling. Les complexes du gallium (III) et du fer (III) d'un ligand macrobicyclique chiral impliquant trois sous-unités de type binaphtol sont étudiés en RMN du proton en solution méthanolique. L'étude du complexe (diamagnétique) du gallium permet de montrer que le complexe : (i) ne subit pas d'inversion de la configuration (Δ/Λ) du site octaédrique et : (ii) qu'il n'y a pas d'échange entre ligand libre et complexe à la température ambiante. L'évolution du spectre du complexe paramagnétique du fer avec la température permet une attribution des protons du ligand et met en évidence la symétrie D3 du complexe. Une bonne corrélation est obtenue entre la distance fer-proton (donnée par la modélisation moléculaire) et le T1 du proton considéré.

Dynamic Testing of Signal Transduction Deregulation During Breast Cancer Initiation

DTIC Science & Technology

2012-07-01

Std. Z39.18 Victoria Seewaldt, M.D. Dynamic Testing of Signal Transduction Deregulation During Breast Cancer Initiation Duke University Durham...attomole- zeptomole range. Internal dilution curves insure a high-dynamic calibration range. DU -26 8L DU -26 6L DU -29 5R DU -22 9.2 L DU...3: Nanobiosensor technology is translated to test for pathway deregulation in RPFNA cytology obtained from 10 high-risk women with cytological

28. View of data test area for DR data take ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. View of data test area for DR data take off set operators panel and cabinet at second floor of transmitter building no. 102 in MIP area. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

Competition entre supraconductivite et magnetisme au voisinage de la transition de Mott dans le conducteur organique quasi-bidimensionnel k-(BEDT-TTF)2copper[N(CN)2]bromine

NASA Astrophysics Data System (ADS)

Fournier, David

Les conducteurs organiques quasi-bidimensionnels kappa-ET2X presentent d'importantes similitudes avec les SCHT telles qu'une phase isolant de Mott, un regime de pseudogap et un etat supraconducteur. L'etude de leurs proprietes apparait donc complementaire. Parmi les interrogations persistantes concernant la physique de ces systemes, l'origine du (ou des) processus exotique d'appariement, responsable de la supraconductivite est le sujet suscitant l'interet le plus marque dans la communaute. L'hypothese d'un mecanisme lie a la proximite d'un etat antiferromagnetique est privilegiee. Une etape importante dans la resolution de cette problematique est l'identification de la symetrie du parametre d'ordre. D'apres de nombreux travaux sur les systemes fortement correles, la sonde ultrasonore, de par sa sensibilite aux excitations de quasiparticule a basse temperature, est consideree comme particulierement adaptee a l'etude de cette propriete. Cependant, son emploi necessite l'utilisation d'un compose metallique a basse temperature et completement supraconducteur. Le compose metallique organique kappa-ET 2Cu[N(CN)2]Br presente toutes les caracteristiques necessaires a l'etude de cette propriete. En effet, il est situe loin de la transition du premier ordre de Mott et est completement supraconducteur. De facon surprenante, ce systeme semble se coupler fortement avec le reseau ce qui augmente significativement la sensibilite de cette sonde aux proprietes du gaz electronique. Cependant, des difficultes techniques importantes, liees a la nature intrinseque de ce materiau, doivent etre surmontees pour proceder a des mesures suivant differentes polarisations. La presente etude a profondement modifie notre comprehension de ce systeme. En effet, ces mesures ont permis de constater que le kappa-ET2Cu[N(CN)2]Br est un compose qui est situe en bordure de la zone de coexistence entre la supraconductivite et le magnetisme, ce qui constitue un resultat totalement inattendu. De plus, la variation judicieuse du cycle thermique s'est averee etre equivalente a une modification de la pression chimique. Cette derniere est modifiee par l'intermediaire d'une relaxation structurale autour de 85 K appelee la transition de verre d'ethylenes. Cela nous a permis de suivre l'evolution de cette coexistence en s'approchant de la transition de premier ordre, et ainsi de statuer sur la competition entre la supraconductivite et le magnetisme ainsi que sur l'existence d'une separation de phase d'ordre macroscopique. De plus, nous avons observe une anisotropie similaire sur les mesures de vitesse ultrasonore entre le regime de pseudogap et la supraconductivite. Ce resultat tend a confirmer l'existence d'une physique commune entre le regime de pseudogap et l'etat supraconducteur. Le regime de pseudogap, encore meconnu a ce jour, est probablement relie a des fluctuations antiferromagnetiques, dont l'origine pourrait etre un emboitement de la surface de Fermi quasi-unidimensionnelle de ce compose, ou bien relie a la proximite de la physique de Mott. Enfin, l'analyse de la symetrie du parametre d'ordre supraconducteur, qui est probablement de type s+d, tend a demontrer que les processus de couplage interplan sont d'une importance cruciale. L'approche theorique de Hubbard purement 2D dans le plan conducteur semble donc insuffisante pour la recherche du mecanisme d'appariement.

Hazardous Waste Cleanup: E.I. DuPont de Nemours & Company in Pompton Lakes, New Jersey

EPA Pesticide Factsheets

E.I. DuPont De Nemours & Company is located at 2000 Cannonball Road, Pompton Lakes, New Jersey. The DuPont Pompton Lakes Works site (DuPont) occupies approximately 570 acres of land in Pompton Lakes and Wanaque.

Influence of depleted uranium on hepatic cholesterol metabolism in apolipoprotein E-deficient mice.

PubMed

Souidi, M; Racine, R; Grandcolas, L; Grison, S; Stefani, J; Gourmelon, P; Lestaevel, P

2012-04-01

Depleted uranium (DU) is uranium with a lower content of the fissile isotope U-235 than natural uranium. It is a radioelement and a waste product from the enrichment process of natural uranium. Because of its very high density, it is used in the civil industry and for military purposes. DU exposure can affect many vital systems in the human body, because in addition to being weakly radioactive, uranium is a toxic metal. It should be emphasized that, to be exposed to radiation from DU, you have to eat, drink, or breathe it, or get it on your skin. This particular study is focusing on the health effects of DU for the cholesterol metabolism. Previous studies on the same issue have shown that the cholesterol metabolism was modulated at molecular level in the liver of laboratory rodents contaminated for nine months with DU. However, this modulation was not correlated with some effects at organs or body levels. It was therefore decided to use a "pathological model" such as hypercholesterolemic apolipoprotein E-deficient laboratory mice in order to try to clarify the situation. The purpose of the present study is to assess the effects of a chronic ingestion (during 3 months) of a low level DU-supplemented water (20 mg L(-1)) on the above mentioned mice in order to determine a possible contamination effect. Afterwards the cholesterol metabolism was studied in the liver especially focused on the gene expressions of cholesterol-catabolising enzymes (CYP7A1, CYP27A1 and CYP7B1), as well as those of associated nuclear receptors (LXRα, FXR, PPARα, and SREBP 2). In addition, mRNA levels of other enzymes of interest were measured (ACAT 2, as well as HMGCoA Reductase and HMGCoA Synthase). The gene expression study was completed with SRB1 and LDLr, apolipoproteins A1 and B and membrane transporters ABC A1, ABC G5. The major effect induced by a low level of DU contamination in apo-E deficient mice was a decrease in hepatic gene expression of the enzyme CYP7B1 (-23%) and nuclear receptors LXRα (-24%), RXR (-32%), HNF4α (-21%) when compared to unexposed ones. These modifications on cholesterol metabolism did not lead to increased disturbances that are specific for apolipoprotein E-deficient mice, suggesting that chronic DU exposure did not worsen the pathology in this experimental model. In conclusion, the results of this study indicate that even for a sensitive pathologic model the exposure to a low dose of DU has no relevant impact. The results confirm the results of our first study carried out on healthy laboratory rodents where a sub-chronic contamination with low dose DU did not affect in vivo the metabolism of cholesterol. Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

Metallothionein deficiency aggravates depleted uranium-induced nephrotoxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hao, Yuhui; Huang, Jiawei; Gu, Ying

Depleted uranium (DU) has been widely used in both civilian and military activities, and the kidney is the main target organ of DU during acute high-dose exposures. In this study, the nephrotoxicity caused by DU in metallothionein-1/2-null mice (MT −/−) and corresponding wild-type (MT +/+) mice was investigated to determine any associations with MT. Each MT −/− or MT +/+ mouse was pretreated with a single dose of DU (10 mg/kg, intraperitoneal injection) or an equivalent volume of saline. After 4 days of DU administration, kidney changes were assessed. After DU exposure, serum creatinine and serum urea nitrogen in MTmore » −/− mice significantly increased than in MT +/+ mice, with more severe kidney pathological damage. Moreover, catalase and superoxide dismutase (SOD) decreased, and generation of reactive oxygen species and malondialdehyde increased in MT −/− mice. The apoptosis rate in MT −/− mice significantly increased, with a significant increase in both Bax and caspase 3 and a decrease in Bcl-2. Furthermore, sodium-glucose cotransporter (SGLT) and sodium-phosphate cotransporter (NaPi-II) were significantly reduced after DU exposure, and the change of SGLT was more evident in MT −/− mice. Finally, exogenous MT was used to evaluate the correlation between kidney changes induced by DU and MT doses in MT −/− mice. The results showed that, the pathological damage and cell apoptosis decreased, and SOD and SGLT levels increased with increasing dose of MT. In conclusion, MT deficiency aggravated DU-induced nephrotoxicity, and the molecular mechanisms appeared to be related to the increased oxidative stress and apoptosis, and decreased SGLT expression. - Highlights: • MT −/− and MT +/+ mice were used to evaluate nephrotoxicity of DU. • Renal damage was more evident in the MT −/− mice after exposure to DU. • Exogenous MT also protects against DU-induced nephrotoxicity. • MT deficiency induced more ROS and apoptosis after exposure to DU. • MT deficiency down-regulated SGLT expression after exposure to DU.« less

Selection for fertility in mice - the selection plateau and how to overcome it.

PubMed

Schüler, L

1985-04-01

A long-term experiment for increasing the traits first day litter size (LS1) and litter weight (LW1) was conducted with two populations for 33 generations. The selection plateau was reached in population DU-C (selection and estrus synchronization (h(2) = 0.02±0.01); in population DU-K (selection) the plateau (h(2) = 0.05±0.2) was nearly reached. Selection progress per generation was in LS1 b = 0.11±0.02; b = 0.12±0.04 (1st to 18th generation DU-K, DU-C) and b = 0.10±0.03; b = 0.07±0.05 (19th to 33rd generation, DU-K, DU-C) in LW1 b = 0.16±0.04 g; 0.19±0.07 g (DU-K, DU-C) b = 0.20±0.09 g; 0.001±0.09 g (DU-K, DU-C). Reverse and relaxe selection as well as systematic inbreeding was applied for 10 generations. Reverse selection yielded h(2) = 0.28±0.11 (R-DU-K) and h(2) = 0.17±0.05 (R-DU-C) and showed that there was still additive genetic variance. Relaxe selection did not cause alterations in the selection parameters, whereas inbreeding lead to inbred depressions (b = LS1 = -0.42±0.15; -0.45±0.12; b = LW1 = -1.13±0.20; -0.82±0.18 I-DU-K, I-DU-C). The plateau was based upon the heterozygote advantage. Several methods for overcoming the plateau were applied. A new selective useful variance could be created by crossing the plateau populations (h(2) = 0.14±0.04). A short-term progress in overcoming the plateau (1st to 3rd generation) could be obtained by litter size standardization (LS = 388). Tandem selection (selection for body weight - BW42) as well as crossing of inbred strains were not suitable for overcoming the selection plateau. Altering the environmental conditions as a possibility for overcoming the plateau has been discussed.

Prevalence of duck circovirus infection of subclinical pekin ducks in South Korea.

PubMed

Cha, Se-Yeoun; Song, Eu-Tteum; Kang, Min; Wei, Bai; Seo, Hye-Suk; Roh, Jae-Hee; Yoon, Ran-Hee; Moon, Oun-Kyoung; Jang, Hyung-Kwan

2014-04-01

An investigation was carried out to determine the prevalence and infection pattern of duck circovirus (DuCV) in subclinical Pekin ducks on South Korean duck farms. A total of 147 samples collected from 92 duck farms in five provinces were examined from 2011 to 2012. The overall prevalence of DuCV PCR-positive pooled bursa of Fabricius and liver samples was 21.8% (32/147). The prevalence of DuCV PCR-positive samples increased significantly in 3-week-old ducks compared with that in 1-week-old ducks (P<0.05). DuCV in association with Riemerella and Salmonella infections (10.9%; 16/147) occurred at the same level as infection with DuCV alone (10.9%; 16/147). In comparison of the relationship between bacterial diseases (salmonellosis, Riemerella infection) and morbidity in farms with and without DuCV, morbidity was higher in circovirus-positive farms (50%; 16/32) than in circovirus-negative farms (26.1%; 30/115). Our findings provide baseline information on the degree of DuCV infection and distribution and pattern of DuCV in ducks, and it is evident that DuCV can be associated with subclinical diseases and that subclinical infection could be economically important.

FAST TRACK COMMUNICATION Initial data for the relativistic gravitational N-body problem

NASA Astrophysics Data System (ADS)

Chruściel, Piotr T.; Corvino, Justin; Isenberg, James

2010-11-01

In general relativity, an initial data set for an isolated gravitational system takes the form of a solution of the Einstein constraint equations which is asymptotically Euclidean on a specified end. Given a collection of N such data sets with a subregion of interest (bounded away from the specified end) chosen in each, we show that there exists a family of new initial data sets, each of which contains exact copies of each of the N chosen subregions, positioned in a chosen array in a single asymptotic end. These composite initial data sets model isolated, relativistic gravitational systems containing N chosen bodies in specified initial configurations.

Measuring aerosols generated inside armoured vehicles perforated by depleted uranium ammunition.

PubMed

Parkhurst, M A

2003-01-01

In response to questions raised after the Gulf War about the health significance of exposure to depleted uranium (DU), the US Department of Defense initiated a study designed to provide an improved scientific basis for assessment of possible health effects on soldiers in vehicles struck by these munitions. As part of this study, a series of DU penetrators were fired at an Abrams tank and a Bradley fighting vehicle, and the aerosols generated by vehicle perforation were collected and characterised. A robust sampling system was designed to collect aerosols in this difficult environment and monitor continuously the sampler flow rates. The aerosol samplers selected for these tests included filter cassettes, cascade impactors, a five-stage cyclone and a moving filter. Sampler redundancy was an integral part of the sampling system to offset losses from fragment damage. Wipe surveys and deposition trays collected removable deposited particulate matter. Interior aerosols were analysed for uranium concentration and particle size distribution as a function of time. They were also analysed for uranium oxide phases, particle morphology and dissolution in vitro. These data, currently under independent peer review, will provide input for future prospective and retrospective dose and health risk assessments of inhaled or ingested DU aerosols. This paper briefly discusses the target vehicles, firing trajectories, aerosol samplers and instrumentation control systems, and the types of analyses conducted on the samples.

Acceptabilité du test VIH proposé aux nourrissons dans les services pédiatriques, en Côte d'Ivoire, Significations pour la couverture du diagnostic pédiatrique

PubMed Central

Oga, Maxime; Brou, Hermann; Dago-Akribi, Hortense; Coffie, Patrick; Amani-Bossé, Clarisse; Ékouévi, Didier; Yapo, Vincent; Menan, Hervé; Ndondoki, Camille; Timité-Konan, M.; Leroy, Valériane

2014-01-01

Résumé Problème: Le dépistage VIH chez les enfants a rarement été au centre des préoccupations des chercheurs. Quand le dépistage pédiatrique a retenu l'attention, cela a été pour éclairer seulement sur les performances diagnostiques en ignorant même que le test pédiatrique comme bien d'autres peut s'accepter ou se refuser. Cet article met au cœur de son analyse les raisons qui peuvent expliquer qu'on accepte ou qu'on refuse de faire dépister son enfant. Objectif: Etudier chez les parents, les mères, les facteurs explicatifs de l'acceptabilité du test VIH des nourrissons de moins de six mois. Méthodes: Entretien semi-directif à passages répétés avec les parents de nourrissons de moins de six mois dans les formations sanitaires pour la pesée/vaccination et les consultations pédiatriques avec proposition systématique d'un test VIH pour leur nourrisson. Résultats: Nous retenons que la réalisation effective du test pédiatrique du VIH chez le nourrisson repose sur trois éléments. Primo, le personnel de santé par son discours (qui dénote de ses connaissances et perceptions même sur l'infection) orienté vers les mères influence leur acceptation ou non du test. Secundo, la mère qui par ses connaissances et perceptions même sur le VIH, dont le statut particulier, l'impression de bien-être chez elle et son enfant influence toute réalisation du test pédiatrique VIH. Tertio, l'environnement conjugal de la mère, particulièrement caractérisé par les rapports au sein du couple, sur la facilité de parler du test VIH et sa réalisation chez les deux parents ou chez la mère seulement sont autant de facteurs qui influencent la réalisation effective du dépistage du VIH chez l'enfant. Le principe préventif du VIH, et le désir de faire tester l'enfant ne suffisent pas à eux seuls pour aboutir à sa réalisation effective, selon certaines mères confrontées au refus du conjoint. A l'opposé, les autres mères refusant la réalisation du test pédiatrique disent s'y opposer ; bien entendu, même dans le cas où le conjoint l'accepterait. Discussion: Les mères sont les principales mises en cause et craignent les réprimandes et la stigmatisation. Le père, le conjoint peut être un obstacle, quand il s'oppose au test VIH du nourrisson, ou devenir le facilitateur de sa réalisation s'il est convaincu. Le positionnement du père demeure donc essentiel dans la question de l'acceptabilité du VIH pédiatrique. Les mères en ont conscience et présagent des difficultés à faire dépister ou non les enfants sans avis préalable du conjoint à la fois père, et chef de famille. Conclusion: La question du dépistage pédiatrique du VIH, au terme de notre analyse, met en face trois éléments qui exigent une gestion globale pour assurer une couverture effective. Ces trois éléments n'existeraient pas sans s'influencer, donc ils sont constamment en interaction et empêchent ou favorisent la réalisation ou non du test pédiatrique. Aussi, dans une intention d'aboutir à une couverture effective du dépistage VIH des nourrissons, faut-il tenir compte d'une gestion harmonieuse de ces trois éléments: La première, la mère seule (avec ses connaissances, ses perceptions), son environnement conjugal (de proposition du test intégrant 1- l’époux et / ou père de l'enfant avec ses perceptions et connaissances sur l'infection 2- la facilité de parler du test et sa réalisation chez les deux ou un des parents, la mère) et les connaissances, attitudes et pratiques du personnel de l’établissement sanitaire sur l'infection du VIH. Recommandations: Nos recommandations proposent une redéfinition de l'approche du VIH/sida vers des familles exposées au VIH et une intégration plus accentuée du père facilitant leur propre acceptation du test VIH et celle de leur enfant. PMID:25088574

Watershed Data Management (WDM) database for Salt Creek streamflow simulation, DuPage County, Illinois, water years 2005-11

USGS Publications Warehouse

Bera, Maitreyee

2014-01-01

The U.S. Geological Survey (USGS), in cooperation with DuPage County Stormwater Management Division, maintains a USGS database of hourly meteorologic and hydrologic data for use in a near real-time streamflow simulation system, which assists in the management and operation of reservoirs and other flood-control structures in the Salt Creek watershed in DuPage County, Illinois. Most of the precipitation data are collected from a tipping-bucket rain-gage network located in and near DuPage County. The other meteorologic data (wind speed, solar radiation, air temperature, and dewpoint temperature) are collected at Argonne National Laboratory in Argonne, Ill. Potential evapotranspiration is computed from the meteorologic data. The hydrologic data (discharge and stage) are collected at USGS streamflow-gaging stations in DuPage County. These data are stored in a Watershed Data Management (WDM) database. An earlier report describes in detail the WDM database development including the processing of data from January 1, 1997, through September 30, 2004, in SEP04.WDM database. SEP04.WDM is updated with the appended data from October 1, 2004, through September 30, 2011, water years 2005–11 and renamed as SEP11.WDM. This report details the processing of meteorologic and hydrologic data in SEP11.WDM. This report provides a record of snow affected periods and the data used to fill missing-record periods for each precipitation site during water years 2005–11. The meteorologic data filling methods are described in detail in Over and others (2010), and an update is provided in this report.

Radiological risk assessment of Capstone depleted uranium aerosols.

PubMed

Hahn, Fletcher F; Roszell, Laurie E; Daxon, Eric G; Guilmette, Raymond A; Parkhurst, Mary Ann

2009-03-01

Assessment of the health risk from exposure to aerosols of depleted uranium (DU) is an important outcome of the Capstone aerosol studies that established exposure ranges to personnel in armored combat vehicles perforated by DU munitions. Although the radiation exposure from DU is low, there is concern that DU deposited in the body may increase cancer rates. Radiation doses to various organs of the body resulting from the inhalation of DU aerosols measured in the Capstone studies were calculated using International Commission on Radiological Protection (ICRP) models. Organs and tissues with the highest calculated committed equivalent 50-y doses were lung and extrathoracic tissues (nose and nasal passages, pharynx, larynx, mouth, and thoracic lymph nodes). Doses to the bone surface and kidney were about 5 to 10% of the doses to the extrathoracic tissues. Organ-specific risks were estimated using ICRP and U.S. Environmental Protection Agency (EPA) methodologies. Risks for crewmembers and first responders were determined for selected scenarios based on the time interval of exposure and for vehicle and armor type. The lung was the organ with the highest cancer mortality risk, accounting for about 97% of the risks summed from all organs. The highest mean lifetime risk for lung cancer for the scenario with the longest exposure time interval (2 h) was 0.42%. This risk is low compared with the natural or background risk of 7.35%. These risks can be significantly reduced by using an existing ventilation system (if operable) and by reducing personnel time in the vehicle immediately after perforation.

Contractor Final Report: For the Technology Demonstration of the Joint Network Defence and Management System (JNDMS)

DTIC Science & Technology

2013-10-01

opérationnel. Importance: Nous avons démontré des fonctions cruciales en utilisant des outils d’entreprise pour comprendre en profondeur un domaine...by the Minister of National Defence, 2009 © Sa Majesté la Reine ( en droit du Canada), telle que représentée par le ministre de la Défense nationale...interarmées de défense et de gestion des réseaux (SIDGR), en vertu du contrat W7714-04-0875/001/SV. Il touche l’exécution et les résultats de cette

Capstone Depleted Uranium Aerosols: Generation and Characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parkhurst, MaryAnn; Szrom, Fran; Guilmette, Ray

2004-10-19

In a study designed to provide an improved scientific basis for assessing possible health effects from inhaling depleted uranium (DU) aerosols, a series of DU penetrators was fired at an Abrams tank and a Bradley fighting vehicle. A robust sampling system was designed to collect aerosols in this difficult environment and continuously monitor the sampler flow rates. Aerosols collected were analyzed for uranium concentration and particle size distribution as a function of time. They were also analyzed for uranium oxide phases, particle morphology, and dissolution in vitro. The resulting data provide input useful in human health risk assessments.

Experimental Assessment of Two Exothermic Systems to Neutralize Landmines

DTIC Science & Technology

2006-02-01

S M 21 A T/ st ee l 4. 9 2 kg (5 lb ) 6” 1’ 0 5” D et on at io n of re si du al e xp lo si ve , cr at er 1 .0 m x...P T- M i-B a III A T/ ba ke lit e 7. 2 5. 0 kg (1 1 lb ) 40 ” 14 ’ 2 8” S m al l D et on at io n of re si du al e xp lo si ve... S m al l c ra te r

Bonded polyimide fuel cell package and method thereof

DOEpatents

Morse, Jeffrey D.; Jankowski, Alan; Graff, Robert T.; Bettencourt, Kerry

2005-11-01

Described herein are processes for fabricating microfluidic fuel cell systems with embedded components in which micron-scale features are formed by bonding layers of DuPont Kapton.TM. polyimide laminate. A microfluidic fuel cell system fabricated using this process is also described.

Method of preparation of bonded polyimide fuel cell package

DOEpatents

Morse, Jeffrey D [Martinez, CA; Jankowski, Alan [Livermore, CA; Graff, Robert T [Modesto, CA; Bettencourt, Kerry [Dublin, CA

2011-04-26

Described herein are processes for fabricating microfluidic fuel cell systems with embedded components in which micron-scale features are formed by bonding layers of DuPont Kapton.TM. polyimide laminate. A microfluidic fuel cell system fabricated using this process is also described.

Personnel

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2006-10-13

Le président du conseil M.Doran explique la décision que le conseil du Cern vient de prendre sur la 4.étape du régime complémentaire des pensions. Le président du comité des finances le Dr.Andersen ainsi que le Prof.Connor(?) prennent aussi la parole

27 CFR 12.21 - List of examples of names by country.

Code of Federal Regulations, 2010 CFR

2010-04-01

...-Fronsac, Cassis, Cerons, Charlemagne, Chateau Chalon, Chateau-Grillet, Chinon, Chorey-les-Beaunes, Clos de Tart, Clos des Lambrays, Clos Saint-Denis, Collioure, Condrieu, Cornas, Coteaux de l'Aubance, Coteaux du Languedoc, Coteaux du Loir, Coteaux du Lyonnais, Coteaux du Tricastin, Cotes de Duras, Cotes de...

27 CFR 12.21 - List of examples of names by country.

Code of Federal Regulations, 2011 CFR

2011-04-01

...-Fronsac, Cassis, Cerons, Charlemagne, Chateau Chalon, Chateau-Grillet, Chinon, Chorey-les-Beaunes, Clos de Tart, Clos des Lambrays, Clos Saint-Denis, Collioure, Condrieu, Cornas, Coteaux de l'Aubance, Coteaux du Languedoc, Coteaux du Loir, Coteaux du Lyonnais, Coteaux du Tricastin, Cotes de Duras, Cotes de...

Fast-ion Dα spectrum diagnostic in the EAST

NASA Astrophysics Data System (ADS)

Hou, Y. M.; Wu, C. R.; Huang, J.; Heidbrink, W. W.; von Hellermann, M. G.; Xu, Z.; Jin, Z.; Chang, J. F.; Zhu, Y. B.; Gao, W.; Chen, Y. J.; Lyu, B.; Hu, R. J.; Zhang, P. F.; Zhang, L.; Gao, W.; Wu, Z. W.; Yu, Y.; Ye, M. Y.

2016-11-01

In toroidal magnetic fusion devices, fast-ion D-alpha diagnostic (FIDA) is a powerful method to study the fast-ion feature. The fast-ion characteristics can be inferred from the Doppler shifted spectrum of Dα light according to charge exchange recombination process between fast ions and probe beam. Since conceptual design presented in the last HTPD conference, significant progress has been made to apply FIDA systems on the Experimental Advanced Superconducting Tokamak (EAST). Both co-current and counter-current neutral beam injectors are available, and each can deliver 2-4 MW beam power with 50-80 keV beam energy. Presently, two sets of high throughput spectrometer systems have been installed on EAST, allowing to capture passing and trapped fast-ion characteristics simultaneously, using Kaiser HoloSpec transmission grating spectrometer and Bunkoukeiki FLP-200 volume phase holographic spectrometer coupled with Princeton Instruments ProEM 1024B eXcelon and Andor DU-888 iXon3 1024 CCD camera, respectively. This paper will present the details of the hardware descriptions and experimental spectrum.

Miniature lowpass filters in low loss 9k7 LTCC

DOE PAGES

Dai, Steve; Hsieh, Lung -Hwa

2015-07-01

DuPont 9k7 low temperature cofired ceramic (LTCC) is a low loss, or high quality factor Q, tape system targeting at radio frequency (RF) applications. This paper reports the effect of a critical process parameter, heating rate, on the densification and dielectric properties of the 9k7 LTCC. The role of competing densification and crystallization during the sintering of 9k7 is discussed. The high Q of DuPont 9K7 can be used to improve RF system performance, for example a better receiver noise figure, by designing embedded passive RF components such as inductors, capacitors and filters. As a result, miniaturized multilayer low passmore » filters (LPF) with a wide stopband were fabricated to showcase the technology.« less

Miniature lowpass filters in low loss 9k7 LTCC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dai, Steve; Hsieh, Lung -Hwa

DuPont 9k7 low temperature cofired ceramic (LTCC) is a low loss, or high quality factor Q, tape system targeting at radio frequency (RF) applications. This paper reports the effect of a critical process parameter, heating rate, on the densification and dielectric properties of the 9k7 LTCC. The role of competing densification and crystallization during the sintering of 9k7 is discussed. The high Q of DuPont 9K7 can be used to improve RF system performance, for example a better receiver noise figure, by designing embedded passive RF components such as inductors, capacitors and filters. As a result, miniaturized multilayer low passmore » filters (LPF) with a wide stopband were fabricated to showcase the technology.« less

Miniature low-pass filter in low-loss 9k7 LTCC

DOE PAGES

Dai, Steve Xunhu; Hsieh, Lung -Hwa

2015-09-30

DuPont 9k7 low-temperature cofired ceramic (LTCC) is a low-loss, or high-quality-factor Q, tape system targeting at radio frequency (RF) applications. This paper reports on the effect of a critical process parameter, the heating rate, on the densification and dielectric properties of the 9k7 LTCC. The role of competing densification and crystallization during the sintering of 9k7 is discussed. The high Q of DuPont 9K7 can be used to improve RF system performance, for example a better receiver noise figure, by designing embedded passive RF components such as inductors, capacitors and filters. Furthermore, miniaturized multilayer low-pass filters (LPF) with a widemore » stopband were fabricated to showcase the technology.« less

Transport de paires EPR dans des structures mesoscopiques

NASA Astrophysics Data System (ADS)

Dupont, Emilie

Dans cette these, nous nous sommes particulierement interesses a la propagation de paires EPR1 delocalisees et localisees, et a l'influence d'un supraconducteur sur le transport de ces paires. Apres une introduction de cette etude, ainsi que du cadre scientifique qu'est l'informatique quantique dans lequel elle s'inscrit, nous allons dans le chapitre 1 faire un rappel sur le systeme constitue de deux points quantiques normaux entoures de deux fils supraconducteurs. Cela nous permettra d'introduire une methode de calcul qui sera reutilisee par la suite, et de trouver egalement le courant Josephson produit par ce systeme transforme en SQUID-dc par l'ajout d'une jonction auxiliaire. Le SQUID permet de mesurer l'etat de spin (singulet ou triplet), et peut etre forme a partir d'autres systemes que nous etudierons ensuite. Dans le chapitre 2, nous rappellerons l'etude detaillee d'un intricateur d'Andreev faite par un groupe de Bale. La matrice T, permettant d'obtenir le courant dans les cas ou les electrons sont separes spatialement ou non, sera etudiee en detail afin d'en faire usage au chapitre suivant. Le chapitre 3 est consacre a l'etude de l'influence du bruit sur le fonctionnement de l'intricateur d'Andreev. Ce bruit modifie la forme du courant jusqu'a aboutir a d'autres conditions de fonctionnement de l'intricateur. En effet, le bruit present sur les points quantiques peut perturber le transport des paires EPR par l'intermediaire des degres de liberte. Nous montrerons que, du fait de l'"intrication" entre la charge de la paire et le bruit, la paire est detruite pour des temps longs. Cependant, le resultat le plus important sera que le bruit perturbe plus le transport des paires delocalisees, qui implique une resonance de Breit-Wigner a deux particules. Le transport parasite n'implique pour sa part qu'une resonance de Breit-Wigner a une particule. Dans le chapitre 4, nous reviendrons au systeme constitue de deux points quantiques entoures de deux fils supraconducteurs, mais ici, les deux points quantiques seront aussi supraconducteurs. On obtiendra alors l'hamiltonien effectif de la meme maniere que precedemment ainsi que la forme du courant. Dans le cas ou la tension entre les deux fils est nulle, nous ferons une comparaison avec l'experience et nous verrons que les resultats obtenus sont plus en accord avec celle-ci si on fait l'hypothese de la presence d'un bain, qui va modeliser le bruit sur l'un des fils. Enfin, dans le dernier chapitre, nous utiliserons a la fois un qubit de charge et un qubit de spin entoures par deux fils supraconducteurs. Nous pourrons alors mesurer l'influence du supraconducteur et voir s'il est possible de creer ici des paires d'electrons intriques et d'aboutir a un pendule quantique. 1Il existe des systemes qui produisent des paires de particules ejectees simultanement dans des directions opposees et qui permettent de tester le paradoxe d' Einstein, Podolsky, Rosen. Chaque particule de la paire est dans un etat indetermine. Si on mesure les etats respectifs des deux particules, on obtient systematiquement des resultats complementaires, soit de facon aleatoire: 0-1 ou 1-0. La mecanique quantique explique que les deux particules ainsi produites constituent un seul systeme, une paire EPR.

Depleted Uranium—Experience of the United Nations Environmental Programme Missions

NASA Astrophysics Data System (ADS)

Åkerblom, Gustav

2008-08-01

Depleted Uranium (DU) is used in ammunition designed for armour-piercing. DU was used in the Gulf war 1991, wars in Bosnia 1994-1995, Kosovo 1999 and Iraq 2003. The United Nations Environmental Programme (UNEP) Post-Conflict Branch investigated sites where DU was used and evaluated health and environmental risks during missions to Kosovo, Serbia and Bosnia. During a mission to Lebanon in 2006, UNEP also sampled areas where DU was supposed to have been used but did not find any DU. Due to the grave risks to the lives of UN personnel, no UNEP mission was carried out in Iraq. UNEP has provided training for personnel engaged in decontamination of DU in Bosnia and Iraq.

Systems engineering approach to environmental risk management: A case study of depleted uranium at test area C-64, Eglin Air Force Base, Florida. Master`s thesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carter, C.M.; Fortmann, K.M.; Hill, S.W.

1994-12-01

Environmental restoration is an area of concern in an environmentally conscious world. Much effort is required to clean up the environment and promote environmentally sound methods for managing current land use. In light of the public consciousness with the latter topic, the United States Air Force must also take an active role in addressing these environmental issues with respect to current and future USAF base land use. This thesis uses the systems engineering technique to assess human health risks and to evaluate risk management options with respect to depleted uranium contamination in the sampled region of Test Area (TA) C-64more » at Eglin Air Force Base (AFB). The research combines the disciplines of environmental data collection, DU soil concentration distribution modeling, ground water modeling, particle resuspension modeling, exposure assessment, health hazard assessment, and uncertainty analysis to characterize the test area. These disciplines are required to quantify current and future health risks, as well as to recommend cost effective ways to increase confidence in health risk assessment and remediation options.« less

Interaction of reward seeking and self-regulation in the prediction of risk taking: A cross-national test of the dual systems model.

PubMed

Duell, Natasha; Steinberg, Laurence; Chein, Jason; Al-Hassan, Suha M; Bacchini, Dario; Lei, Chang; Chaudhary, Nandita; Di Giunta, Laura; Dodge, Kenneth A; Fanti, Kostas A; Lansford, Jennifer E; Malone, Patrick S; Oburu, Paul; Pastorelli, Concetta; Skinner, Ann T; Sorbring, Emma; Tapanya, Sombat; Uribe Tirado, Liliana Maria; Alampay, Liane Peña

2016-10-01

In the present analysis, we test the dual systems model of adolescent risk taking in a cross-national sample of over 5,200 individuals aged 10 through 30 (M = 17.05 years, SD = 5.91) from 11 countries. We examine whether reward seeking and self-regulation make independent, additive, or interactive contributions to risk taking, and ask whether these relations differ as a function of age and culture. To compare across cultures, we conduct 2 sets of analyses: 1 comparing individuals from Asian and Western countries, and 1 comparing individuals from low- and high-GDP countries. Results indicate that reward seeking and self-regulation have largely independent associations with risk taking and that the influences of each variable on risk taking are not unique to adolescence, but that their link to risk taking varies across cultures. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

A la Recherche du Temps Perdu: extracting temporal relations from medical text in the 2012 i2b2 NLP challenge.

PubMed

Cherry, Colin; Zhu, Xiaodan; Martin, Joel; de Bruijn, Berry

2013-01-01

An analysis of the timing of events is critical for a deeper understanding of the course of events within a patient record. The 2012 i2b2 NLP challenge focused on the extraction of temporal relationships between concepts within textual hospital discharge summaries. The team from the National Research Council Canada (NRC) submitted three system runs to the second track of the challenge: typifying the time-relationship between pre-annotated entities. The NRC system was designed around four specialist modules containing statistical machine learning classifiers. Each specialist targeted distinct sets of relationships: local relationships, 'sectime'-type relationships, non-local overlap-type relationships, and non-local causal relationships. The best NRC submission achieved a precision of 0.7499, a recall of 0.6431, and an F1 score of 0.6924, resulting in a statistical tie for first place. Post hoc improvements led to a precision of 0.7537, a recall of 0.6455, and an F1 score of 0.6954, giving the highest scores reported on this task to date. Methods for general relation extraction extended well to temporal relations, and gave top-ranked state-of-the-art results. Careful ordering of predictions within result sets proved critical to this success.

Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel

PubMed Central

Kharaziha, Pedram; Chioureas, Dimitris; Rutishauser, Dorothea; Baltatzis, George; Lennartsson, Lena; Fonseca, Pedro; Azimi, Alireza; Hultenby, Kjell; Zubarev, Roman; Ullén, Anders; Yachnin, Jeffrey; Nilsson, Sten; Panaretakis, Theocharis

2015-01-01

Docetaxel is a cornerstone treatment for metastatic, castration resistant prostate cancer (CRPC) which remains a leading cause of cancer-related deaths, worldwide. The clinical usage of docetaxel has resulted in modest gains in survival, primarily due to the development of resistance. There are currently no clinical biomarkers available that predict whether a CRPC patient will respond or acquire resistance to this therapy. Comparative proteomics analysis of exosomes secreted from DU145 prostate cancer cells that are sensitive (DU145 Tax-Sen) or have acquired resistance (DU145 Tax-Res) to docetaxel, demonstrated significant differences in the amount of exosomes secreted and in their molecular composition. A panel of proteins was identified by proteomics to be differentially enriched in DU145 Tax-Res compared to DU145 Tax-Sen exosomes and was validated by western blotting. Importantly, we identified MDR-1, MDR-3, Endophilin-A2 and PABP4 that were enriched only in DU145 Tax-Res exosomes. We validated the presence of these proteins in the serum of a small cohort of patients. DU145 cells that have uptaken DU145 Tax-Res exosomes show properties of increased matrix degradation. In summary, exosomes derived from DU145 Tax-Res cells may be a valuable source of biomarkers for response to therapy. PMID:25844599

Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.

PubMed

Kharaziha, Pedram; Chioureas, Dimitris; Rutishauser, Dorothea; Baltatzis, George; Lennartsson, Lena; Fonseca, Pedro; Azimi, Alireza; Hultenby, Kjell; Zubarev, Roman; Ullén, Anders; Yachnin, Jeffrey; Nilsson, Sten; Panaretakis, Theocharis

2015-08-28

Docetaxel is a cornerstone treatment for metastatic, castration resistant prostate cancer (CRPC) which remains a leading cause of cancer-related deaths, worldwide. The clinical usage of docetaxel has resulted in modest gains in survival, primarily due to the development of resistance. There are currently no clinical biomarkers available that predict whether a CRPC patient will respond or acquire resistance to this therapy. Comparative proteomics analysis of exosomes secreted from DU145 prostate cancer cells that are sensitive (DU145 Tax-Sen) or have acquired resistance (DU145 Tax-Res) to docetaxel, demonstrated significant differences in the amount of exosomes secreted and in their molecular composition. A panel of proteins was identified by proteomics to be differentially enriched in DU145 Tax-Res compared to DU145 Tax-Sen exosomes and was validated by western blotting. Importantly, we identified MDR-1, MDR-3, Endophilin-A2 and PABP4 that were enriched only in DU145 Tax-Res exosomes. We validated the presence of these proteins in the serum of a small cohort of patients. DU145 cells that have uptaken DU145 Tax-Res exosomes show properties of increased matrix degradation. In summary, exosomes derived from DU145 Tax-Res cells may be a valuable source of biomarkers for response to therapy.

Depleted Uranium and Human Health.

PubMed

Faa, Armando; Gerosa, Clara; Fanni, Daniela; Floris, Giuseppe; Eyken, Peter V; Lachowicz, Joanna I; Nurchi, Valeria M

2018-01-01

Depleted uranium (DU) is generally considered an emerging pollutant, first extensively introduced into environment in the early nineties in Iraq, during the military operation called "Desert Storm". DU has been hypothesized to represent a hazardous element both for soldiers exposed as well as for the inhabitants of the polluted areas in the war zones. In this review, the possible consequences on human health of DU released in the environment are critically analyzed. In the first part, the chemical properties of DU and the principal civil and military uses are summarized. A concise analysis of the mechanisms underlying absorption, blood transport, tissue distribution and excretion of DU in the human body is the subject of the second part of this article. The following sections deal with pathological condition putatively associated with overexposure to DU. Developmental and birth defects, the Persian Gulf syndrome, and kidney diseases that have been associated to DU are the arguments treated in the third section. Finally, data regarding DU exposure and cancer insurgence will be critically analyzed, including leukemia/lymphoma, lung cancer, uterine cervix cancer, breast cancer, bladder cancer and testicular cancer. The aim of the authors is to give a contribution to the debate on DU and its effects on human health and disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Characterization of FaDu-R, a radioresistant head and neck cancer cell line, and cancer stem cells.

PubMed

Cho, Kwang-Jae; Park, Eun-Ji; Kim, Min-Sik; Joo, Young-Hoon

2018-06-01

The aim of this study was to evaluate the impact of CSC on insensitivity to radiotherapy in HNSCC. A radioresistant cell line, FaDu-R, was established using fractionated ionizing radiation. Cells with high and low CD44/ALDH activity were isolated. FaDu-R cells demonstrated significantly increased cell viability after radiation exposure compared with parental cells. CD44 high /ALDH high FaDu-R cells demonstrated significantly faster wound closure (p<0.05) and more efficient invasion (p<0.05) compared to the CD44 high /ALDH high FaDu cells or the CD44 low /ALDH low FaDu-R cells. There was a significant difference in tumor volume between the CD44 high /ALDH high FaDu-R cells and the CD44 high /ALDH high FaDu cells (p<0.05) as well as the CD44 low /ALDH low FaDu-R cells (p<0.05). Cancer stem cells (CSC) were associated with invasion and tumorigenesis in a radioresistant head and neck squamous cell carcinoma (HNSCC) cell line. This concept might help to improve the understanding of these mechanisms and to develop drugs that can overcome radioresistance during radiotherapy. Copyright © 2017 Elsevier B.V. All rights reserved.

Higher Education for Public Value: Taking the Debate beyond New Public Management

ERIC Educational Resources Information Center

Broucker, Bruno; De Wit, Kurt; Verhoeven, Jef C.

2018-01-01

Many higher education (HE) system reforms in the past decades have been built on the paradigm of New Public Management (NPM). However, these reforms have not allowed HE to fully take its value for society into account. In recent years a growing call can be heard to orient the HE sector towards more collaboration, a focus on a larger set of…

A Decomposition of Hospital Profitability

PubMed Central

Broom, Kevin; Elliott, Michael; Lee, Jen-Fu

2015-01-01

Objectives: This paper evaluates the drivers of profitability for a large sample of U.S. hospitals. Following a methodology frequently used by financial analysts, we use a DuPont analysis as a framework to evaluate the quality of earnings. By decomposing returns on equity (ROE) into profit margin, total asset turnover, and capital structure, the DuPont analysis reveals what drives overall profitability. Methods: Profit margin, the efficiency with which services are rendered (total asset turnover), and capital structure is calculated for 3,255 U.S. hospitals between 2007 and 2012 using data from the Centers for Medicare & Medicaid Services’ Healthcare Cost Report Information System (CMS Form 2552). The sample is then stratified by ownership, size, system affiliation, teaching status, critical access designation, and urban or non-urban location. Those hospital characteristics and interaction terms are then regressed (OLS) against the ROE and the respective DuPont components. Sensitivity to regression methodology is also investigated using a seemingly unrelated regression. Results: When the sample is stratified by hospital characteristics, the results indicate investor-owned hospitals have higher profit margins, higher efficiency, and are substantially more leveraged. Hospitals in systems are found to have higher ROE, margins, and efficiency but are associated with less leverage. In addition, a number of important and significant interactions between teaching status, ownership, location, critical access designation, and inclusion in a system are documented. Many of the significant relationships, most notably not-for-profit ownership, lose significance or are predominately associated with one interaction effect when interaction terms are introduced as explanatory variables. Results are not sensitive to the alternative methodology. Conclusion: The results of the DuPont analysis suggest that although there appears to be convergence in the behavior of NFP and IO hospitals, significant financial differences remain depending on their respective hospital characteristics. Those differences are tempered or exacerbated by location, size, teaching status, system affiliation, and critical access designation. With the exception of cost-based reimbursement for critical access hospitals, emerging payment systems are placing additional financial pressures on hospitals. The financial pressures being applied treat hospitals as a monolithic category and, given the delicate and often negative ROE for many hospitals, the long-term stability of the healthcare facility infrastructure may be negatively impacted. PMID:28462258

Identification of alternatively spliced isoforms of interleukin-2/15 receptor β chain in ducks.

PubMed

Jeong, Jipseol; Kim, Woo H; Yeo, Jaeseung; Fernandez, Cherry P; Kim, Suk; Lee, Youn-Jeong; Lillehoj, Hyun S; Min, Wongi

2014-12-15

Interleukin (IL)-2 and IL-15 receptor β (IL-2/15Rβ, CD122) play important roles in signal transduction for biological functions of IL-2 and IL-15. We found that ducks possess three different IL-2/15Rβ transcripts, a conventional form (duIL-2/15Rβ) and two variants. Comparisons between the cDNA and genomic sequences revealed that the two variants, duIL-2/15Rβ-d7 and duIL-2/15Rβ-d9, were novel spliced transcripts resulting from skipping exons 7 and 9, respectively. Expression profiles of duIL-2/15Rβ and its isoforms were examined in healthy tissues, concanavalin A (ConA)-stimulated splenic lymphocytes and in livers and spleens of Riemerella anatipestifer-infected ducks using quantitative real-time PCR (qRT-PCR). Generally, duIL-2/15Rβ-d9 expression was undetectable in healthy tissues, ConA-activated samples, and R. anatipestifer-infected ducks. Expression levels of duIL-2/15Rβ transcript were relatively high to moderate in all healthy tissues tested, while duIL-2/15Rβ-d7 expression was low. Compared to untreated controls, expression levels of duIL-2/15Rβ were elevated in ConA-activated splenic lymphocytes and in livers on day 7 in R. anatipestifer-infected ducks, while duIL-2/15Rβ-d7 expression was unchanged. Additionally, COS-7 cells transfected with duIL-2/15Rβ, duIL-2/15Rβ-d7, or duIL-2/15Rβ-d9 constructs generated 73 kilodalton (kDa), 31kDa, and 40kDa proteins, respectively. This study identified three different IL-2/15Rβ transcripts, including two isoforms generated by alternative splicing and their gene expression patterns in stimulated conditions. Copyright © 2014 Elsevier B.V. All rights reserved.

Lignes directrices sur l’aiguillage des cas soupçonnés de cancer du poumon par un médecin de famille ou autre professionnel des soins primaires

PubMed Central

Del Giudice, M. Elisabeth; Young, Sheila-Mae; Vella, Emily T.; Ash, Marla; Bansal, Praveen; Robinson, Andrew; Skrastins, Roland; Ung, Yee; Zeldin, Robert; Levitt, Cheryl

2014-01-01

Résumé Objectif Les présentes lignes directrices visent à aider les médecins de famille et autres généralistes à reconnaître les manifestations cliniques devant éveiller les soupçons quant à la présence d’un cancer du poumon chez les patients. Composition du comité Les membres du comité ont été choisis parmi les leaders régionaux en soins primaires du Réseau provincial des soins primaires et de la lutte contre le cancer d’Action Cancer Ontario et parmi les membres du Groupe sur le siège de la maladie, Cancer du poumon d’Action Cancer Ontario. Méthodes Les présentes lignes directrices sont le fruit d’une revue systématique des données probantes, d’une synthèse des données et d’un examen externe formel effectué par des intervenants canadiens qui ont validé la pertinence des recommandations. Rapport Ces lignes directrices fondées sur des données probantes ont été formulées pour améliorer la prise en charge en contexte canadien des patients qui présentent des manifestations cliniques du cancer du poumon. Conclusion Le dépistage et l’aiguillage précoces des patients atteints de cancer du poumon pourraient en fin de compte aider à réduire les morbidités et mortalités liées au cancer. Ces lignes directrices pourraient aussi s’avérer utiles dans la mise sur pied de programmes de diagnostic du cancer du poumon et pour aider les décideurs à veiller à ce que les ressources appropriées soient en place.

Challenges in adapting existing clinical natural language processing systems to multiple, diverse health care settings.

PubMed

Carrell, David S; Schoen, Robert E; Leffler, Daniel A; Morris, Michele; Rose, Sherri; Baer, Andrew; Crockett, Seth D; Gourevitch, Rebecca A; Dean, Katie M; Mehrotra, Ateev

2017-09-01

Widespread application of clinical natural language processing (NLP) systems requires taking existing NLP systems and adapting them to diverse and heterogeneous settings. We describe the challenges faced and lessons learned in adapting an existing NLP system for measuring colonoscopy quality. Colonoscopy and pathology reports from 4 settings during 2013-2015, varying by geographic location, practice type, compensation structure, and electronic health record. Though successful, adaptation required considerably more time and effort than anticipated. Typical NLP challenges in assembling corpora, diverse report structures, and idiosyncratic linguistic content were greatly magnified. Strategies for addressing adaptation challenges include assessing site-specific diversity, setting realistic timelines, leveraging local electronic health record expertise, and undertaking extensive iterative development. More research is needed on how to make it easier to adapt NLP systems to new clinical settings. A key challenge in widespread application of NLP is adapting existing systems to new clinical settings. © The Author 2017. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com

Overall view of test set-up in bldg 13 at JSC during docking set-up tests

NASA Image and Video Library

1974-08-04

S74-27049 (4 Aug. 1974) --- Overall view of test set-up in Building 23 at the Johnson Space Center during testing of the docking mechanisms for the joint U.S.-USSR Apollo-Soyuz Test Project. The cinematic check was being made when this picture was taken. The test control room is on the right. The Soviet-developed docking system is atop the USA-NASA developed docking system. Both American and Soviet engineers can be seen taking part in the docking testing. The ASTP docking mission in Earth orbit is scheduled for July 1975.

High frequency EMI sensing for estimating depleted uranium radiation levels in soil

NASA Astrophysics Data System (ADS)

Shubitidze, Fridon; Barrowes, Benjamin E.; Ballard, John; Unz, Ron; Randle, Adam; Larson, Steve L.; O'Neill, Kevin A.

2018-04-01

This paper studies high (100 kHz up to 15 MHz) frequency electromagnetic responses (HFEMI) for DU metallic pieces and DU contaminated soils and derives a simple empirical expression from the measured HFEMI data for estimating DU contamination levels in soil. Depleted uranium (DU) is the byproduct of uranium enrichment and contains 33% less radioactive isotopes than natural uranium. There are at least thirty facilities at fourteen separate locations in the US, where munitions containing DU have been evaluated or used for training. At these sites, which vary in size, evaluation studies have been conducted with and without catch boxes. In addition, the DoD used DU at open firing ranges as large as thousands of acres (hundreds of hectares), for both artillery and aircraft training. These activities have left a legacy of DU contamination. Currently at military sites where DU munitions have been or are being used, cleanup activities mainly are done by excavating and shipping large volumes of site soil and berm materials to a hazardous material radiation disposal site. This approach is very time consuming, costly, and associated with the potential for exposure of personnel performing excavation and transportation. It also limits range use during the operation. So, there is an urgent need for technologies for rapid surveying of large areas to detect, locate, and removal of DU contaminants at test sites. Additionally, the technologies are needed to detect material at a depth of at least 30 cm as well as discriminate between DU metals and oxides from natural uranium and from other conductive metals such as natural and man-made range clutter. One of the potential technologies for estimating DU radiation levels in soils is HFEMI sensing. In this paper, HFEMI signals are collected for DU metal pieces, sodium diunarate (Na2U2 O3) and tri-uranium octoxide (U3O8). The EMI signal's sensitivity with respect to DU material composition and conditions are illustrated and analyzed. A new scheme for extracting near-surface soil's EM parameters is formulated.

Prévalence du portage asymptomatique du plasmodium chez les donneurs bénévoles de sang à Kisangani, République Démocratique du Congo

PubMed Central

Bassandja, Jacques Ossinga; Agasa, Salomon Batina; Likwela, Joris Losimba

2014-01-01

Introduction Le paludisme transfusionnel est une réalité en Afrique Sub-saharienne, en raison des transfusions sanguines répétées, peu ou non contrôlées et où les donneurs sont en majorité potentiellement porteurs d'hématozoaires. L'objectif de cette étude était de déterminer la prévalence du portage asymptomatique du plasmodium chez les donneurs bénévoles de sang à Kisangani. Méthodes Une étude transversale a été menée au Centre Provincial de Transfusion Sanguine à Kisangani du 1er Décembre 2012 au 31 Mars 2013 et a concerné 480 donneurs bénévoles de sang. Résultats La prévalence du portage asymptomatique du plasmodium chez les donneurs bénévoles de sang était de 28,3%. Plasmodium falciparum était l'espèce la plus répandue (96,3%). Près de la moitié des donneurs avait une parasitémie supérieure à 2000 parasites/µl. Les facteurs qui étaient significativement associés à la parasitémie étaient le jeune âge, le 1er don, et la non utilisation de la moustiquaire imprégnée d'insecticide à longue durée (MILD). Conclusion Les résultats de cette étude montrent que la prévalence du portage asymptomatique du plasmodium chez les donneurs bénévoles de sang était élevée, constituant ainsi un risque important de transmission du parasite aux receveurs souvent en mauvais état général. Cependant, l'utilisation de la MILD et la fidélisation des donneurs bénévoles semblent constituer des moyens utiles de réduction du risque de portage asymptomatique du Plasmodium. Une sensibilisation et éventuellement des distributions ciblées de MILD aux donneurs, en particuliers les plus jeunes, pourraient réduire considérablement le portage du Plasmodium parmi les donneurs de sang et ainsi réduire le risque de paludisme transfusionnel. PMID:25328616

Le role du phytoplancton de petite taille (<20 mum) dans les variations des proprietes optiques des eaux du Saint-Laurent

NASA Astrophysics Data System (ADS)

Mas, Sebastien

Les mesures satellitaires de couleur des oceans sont largement determinees par les proprietes optiques inherentes (IOPs) des eaux de surface. D'autre part, le phytoplancton de petite taille (<20 mum) est le plus souvent dominant dans les oceans, et peut donc etre une source importante de variation des IOPs dans les oceans. Dans ce contexte, le but principal de ce doctorat etait de definir l'impact du phytoplancton (<20 mum) sur les variations des proprietes optiques de l'Estuaire et du Golfe du Saint-Laurent (Canada). Afin d'atteindre cet objectif, il etait necessaire de determiner en milieu controle les facteurs de variabilite des proprietes optiques cellulaires et des IOPs du phytoplancton (<20 mum) des eaux du Saint-Laurent, et d'evaluer la contribution du phytoplancton (<20 mum) aux proprietes optiques totales des eaux du Saint-Laurent. Des experiences en laboratoire ont montre que les variations des proprietes optiques des cellules phytoplanctoniques soumises a un cycle jour-nuit, ainsi qu'a des changements concomitants d'intensite lumineuse, peuvent contribuer significativement a la variabilite des proprietes optiques observee en milieu naturel. D'autres experiences ont, quant a elles, mis en evidence que les variations des proprietes optiques des cellules phytoplanctoniques dues aux phases de croissance peuvent alterer les IOPs des oceans, particulierement pendant les periodes de floraison. De plus, la presence de bacteries et de particules detritiques peut egalement affecter la variabilite des IOPs totales, notamment la diffusion. Au printemps, dans l'Estuaire et le Golfe du Saint-Laurent, la contribution du phytoplancton <20 mum aux IOPs presentait des differences regionales evidentes pour les proprietes d'absorption et de diffusion. En plus de la variabilite spatiale, les proprietes optiques cellulaires presentaient des variations journalieres, et ce particulierement pour le picophytoplancton. Enfin, la plupart des differences observees dans les proprietes biooptiques, particulierement l'absorption, etaient attribuables a la contribution du phytoplancton <20 mum. Ceci confirme l'importance de la structure de taille des communautes phytoplanctoniques dans les modeles bio-optiques appliques au Saint-Laurent. L'ensemble des resultats a permis de mettre en evidence l'importance des mecanismes de photoacclimatation et de synchronisation du cycle cellulaire du phytoplancton sur les variations journalieres des IOPs, ainsi que de l'etat physiologique relie au stade de croissance sur les variations temporelles a long terme des IOPs. De plus, le phytoplancton <20 mum contribue de maniere importante aux IOPs et a leur variabilite dans l'Estuaire et le Golfe du St-Laurent, et ce particulierement pour l'absorption. Cette etude de doctorat souligne donc l'importance du phytoplancton <20 mum sur la variabilite des IOPs des oceans.

Genomic characterization of putative allergen genes in peach/almond and their synteny with apple

PubMed Central

Chen, Lin; Zhang, Shuiming; Illa, Eudald; Song, Lijuan; Wu, Shandong; Howad, Werner; Arús, Pere; Weg, Eric van de; Chen, Kunsong; Gao, Zhongshan

2008-01-01

Background Fruits from several species of the Rosaceae family are reported to cause allergic reactions in certain populations. The allergens identified belong to mainly four protein families: pathogenesis related 10 proteins, thaumatin-like proteins, lipid transfer proteins and profilins. These families of putative allergen genes in apple (Mal d 1 to 4) have been mapped on linkage maps and subsequent genetic study on allelic diversity and hypoallergenic traits has been carried out recently. In peach (Prunus persica), these allergen gene families are denoted as Pru p 1 to 4 and for almond (Prunus dulcis)Pru du 1 to 4. Genetic analysis using current molecular tools may be helpful to establish the cause of allergenicity differences observed among different peach cultivars. This study was to characterize putative peach allergen genes for their genomic sequences and linkage map positions, and to compare them with previously characterized homologous genes in apple (Malus domestica). Results Eight Pru p/du 1 genes were identified, four of which were new. All the Pru p/du 1 genes were mapped in a single bin on the top of linkage group 1 (G1). Five Pru p/du 2 genes were mapped on four different linkage groups, two very similar Pru p/du 2.01 genes (A and B) were on G3, Pru p/du 2.02 on G7,Pru p/du 2.03 on G8 and Pru p/du 2.04 on G1. There were differences in the intron and exon structure in these Pru p/du 2 genes and in their amino acid composition. Three Pru p/du 3 genes (3.01–3.03) containing an intron and a mini exon of 10 nt were mapped in a cluster on G6. Two Pru p/du 4 genes (Pru p/du 4.01 and 4.02) were located on G1 and G7, respectively. The Pru p/du 1 cluster on G1 aligned to the Mal d 1 clusters on LG16; Pru p/du 2.01A and B on G3 to Mal d 2.01A and B on LG9; the Pru p/du 3 cluster on G6 to Mal d 3.01 on LG12; Pru p/du 4.01 on G1 to Mal d 4.03 on LG2; and Pru p/du 4.02 on G7 to Mal d 4.02 on LG2. Conclusion A total of 18 putative peach/almond allergen genes have been mapped on five linkage groups. Their positions confirm the high macro-synteny between peach/almond and apple. The insight gained will help to identify key genes causing differences in allergenicity among different cultivars of peach and other Prunus species. PMID:19014629

Identification of two functional nuclear localization signals in the capsid protein of duck circovirus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiang, Qi-Wang; Zou, Jin-Feng; Wang, Xin

The capsid protein (CP) of duck circovirus (DuCV) is the major immunogenic protein and has a high proportion of arginine residues concentrated at the N terminus of the protein, which inhibits efficient mRNA translation in prokaryotic expression systems. In this study, we investigated the subcellular distribution of DuCV CP expressed via recombinant baculoviruses in Sf9 cells and the DNA binding activities of the truncated recombinant DuCV CPs. The results showed that two independent bipartite nuclear localization signals (NLSs) situated at N-terminal 1-17 and 18-36 amino acid residue of the CP. Moreover, two expression level regulatory signals (ELRSs) and two DNAmore » binding signals (DBSs) were also mapped to the N terminus of the protein and overlapped with the two NLSs. The ability of CP to bind DNA, coupled with the karyophilic nature of this protein, strongly suggests that it may be responsible for nuclear targeting of the viral genome.« less

Les premières phases d'édification du stratovolcan du Cantal (Massif central, France) entre 9,5 et 8,0Ma : géologie et géochimie du secteur de l'ÉlancèzeFirst stage of the Cantal stratovolcano (Massif Central, France) construction between 9.5 and 8.0Ma: geology and geochemistry of the Élancèze area

NASA Astrophysics Data System (ADS)

Legendre, Christelle; Caroff, Martial; Leyrit, Hervé; Nehlig, Pierre; Thièblemont, Denis

2001-05-01

Recent cartography of the Élancèze area resulted in the identification of a residual ancient topographic relief comprised of basaltic and intermediate silica-saturated lavas partly covered by brecciated formations, emplaced during the first stage of edification of the Cantal stratovolcano (9.5-8.0 Ma). The ancient relief has been the subject of a specified petrological study. Although the corresponding mineralogical and geochemical data are rather consistent with the assumption of a differentiation mainly governed by fractional crystallization, the study of some incompatible trace element diagrams suggests that this process cannot have occurred in closed-system. A model of crustal assimilation coupled with fractional crystallization involving an amphibole-bearing cumulate is proposed.

Community-campus partnership in action: lessons learned from the DuPage County Patient Navigation Collaborative.

PubMed

Samaras, Athena T; Murphy, Kara; Nonzee, Narissa J; Endress, Richard; Taylor, Shaneah; Hajjar, Nadia; Bularzik, Rosario; Frankovich, Carmi; Dong, XinQi; Simon, Melissa A

2014-01-01

Using community-based participatory research (CBPR), the DuPage County Patient Navigation Collaborative (DPNC) developed an academic campus-community research partnership aimed at increasing access to care for underserved breast and cervical cancer patients within DuPage County, a collar county of Chicago. Given rapidly shifting demographics, targeting CBPR initiatives among underserved suburban communities is essential. To discuss the facilitating factors and lessons learned in forging the DPNC. A patient navigation collaborative was formed to guide medically underserved women through diagnostic resolution and if necessary, treatment, after an abnormal breast or cervical cancer screening. Facilitating factors included (1) fostering and maintaining collaborations within a suburban context, (2) a systems-based participatory research approach, (3) a truly equitable community-academic partnership, (4) funding adaptability, (5) culturally relevant navigation, and (6) emphasis on co-learning and capacity building. By highlighting the strategies that contributed to DPNC success, we envision the DPNC to serve as a feasible model for future health interventions.

Aerosol Sampling System for Collection of Capstone Depleted Uranium Particles in a High-Energy Environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holmes, Thomas D.; Guilmette, Raymond A.; Cheng, Yung-Sung

2009-03-01

The Capstone Depleted Uranium Aerosol Study was undertaken to obtain aerosol samples resulting from a kinetic-energy cartridge with a large-caliber depleted uranium (DU) penetrator striking an Abrams or Bradley test vehicle. The sampling strategy was designed to (1) optimize the performance of the samplers and maintain their integrity in the extreme environment created during perforation of an armored vehicle by a DU penetrator, (2) collect aerosols as a function of time post-impact, and (3) obtain size-classified samples for analysis of chemical composition, particle morphology, and solubility in lung fluid. This paper describes the experimental setup and sampling methodologies used tomore » achieve these objectives. Custom-designed arrays of sampling heads were secured to the inside of the target in locations approximating the breathing zones of the vehicle commander, loader, gunner, and driver. Each array was designed to support nine filter cassettes and nine cascade impactors mounted with quick-disconnect fittings. Shielding and sampler placement strategies were used to minimize sampler loss caused by the penetrator impact and the resulting fragments of eroded penetrator and perforated armor. A cyclone train was used to collect larger quantities of DU aerosol for chemical composition and solubility. A moving filter sample was used to obtain semicontinuous samples for depleted uranium concentration determination. Control for the air samplers was provided by five remotely located valve control and pressure monitoring units located inside and around the test vehicle. These units were connected to a computer interface chassis and controlled using a customized LabVIEW engineering computer control program. The aerosol sampling arrays and control systems for the Capstone study provided the needed aerosol samples for physicochemical analysis, and the resultant data were used for risk assessment of exposure to DU aerosol.« less

Etude de la dynamique des porteurs dans des nanofils de silicium par spectroscopie terahertz

NASA Astrophysics Data System (ADS)

Beaudoin, Alexandre

Ce memoire presente une etude des proprietes de conduction electrique et de la dynamique temporelle des porteurs de charges dans des nanofils de silicium sondes par rayonnement terahertz. Les cas de nanofils de silicium non intentionnellement dopes et dopes type n sont compares pour differentes configurations du montage experimental. Les mesures de spectroscopie terahertz en transmission montre qu'il est possible de detecter la presence de dopants dans les nanofils via leur absorption du rayonnement terahertz (˜ 1--12 meV). Les difficultes de modelisation de la transmission d'une impulsion electromagnetique dans un systeme de nanofils sont egalement discutees. La detection differentielle, une modification au systeme de spectroscopie terahertz, est testee et ses performances sont comparees au montage de caracterisation standard. Les instructions et des recommendations pour la mise en place de ce type de mesure sont incluses. Les resultats d'une experience de pompe optique-sonde terahertz sont egalement presentes. Dans cette experience, les porteurs de charge temporairement crees suite a l'absorption de la pompe optique (lambda ˜ 800 nm) dans les nanofils (les photoporteurs) s'ajoutent aux porteurs initialement presents et augmentent done l'absorption du rayonnement terahertz. Premierement, l'anisotropie de l'absorption terahertz et de la pompe optique par les nanofils est demontree. Deuxiemement, le temps de recombinaison des photoporteurs est etudie en fonction du nombre de photoporteurs injectes. Une hypothese expliquant les comportements observes pour les nanofils non-dopes et dopes-n est presentee. Troisiemement, la photoconductivite est extraite pour les nanofils non-dopes et dopes-n sur une plage de 0.5 a 2 THz. Un lissage sur la photoconductivite permet d'estimer le nombre de dopants dans les nanofils dopes-n. Mots-cles: nanofil, silicium, terahertz, conductivite, spectroscopie, photoconductivite.

Tropospheric GOM at the Pic du Midi Observatory-Correcting Bias in Denuder Based Observations.

PubMed

Marusczak, Nicolas; Sonke, Jeroen E; Fu, Xuewu; Jiskra, Martin

2017-01-17

Gaseous elemental mercury (GEM, Hg) emissions are transformed to divalent reactive Hg (RM) forms throughout the troposphere and stratosphere. RM is often operationally quantified as the sum of particle bound Hg (PBM) and gaseous oxidized Hg (GOM). The measurement of GOM and PBM is challenging and under mounting criticism. Here we intercompare six months of automated GOM and PBM measurements using a Tekran (TK) KCl-coated denuder and quartz regenerable particulate filter method (GOM TK , PBM TK , and RM TK ) with RM CEM collected on cation exchange membranes (CEMs) at the high altitude Pic du Midi Observatory. We find that RM TK is systematically lower by a factor of 1.3 than RM CEM . We observe a significant relationship between GOM TK (but not PBM TK ) and Tekran flush TK blanks suggesting significant loss (36%) of labile GOM TK from the denuder or inlet. Adding the flush TK blank to RM TK results in good agreement with RM CEM (slope = 1.01, r 2 = 0.90) suggesting we can correct bias in RM TK and GOM TK . We provide a bias corrected (*) Pic du Midi data set for 2012-2014 that shows GOM* and RM* levels in dry free tropospheric air of 198 ± 57 and 229 ± 58 pg m -3 which agree well with in-flight observed RM and with model based GOM and RM estimates.

Personnel

ScienceCinema

None

2017-12-09

Le président du conseil M.Doran explique la décision que le conseil du Cern vient de prendre sur la 4.étape du régime complémentaire des pensions. Le président du comité des finances le Dr.Andersen ainsi que le Prof.Connor(?) prennent aussi la parole

W.E.B. DuBois and the Concepts of Race and Class.

ERIC Educational Resources Information Center

Green, Dan S.; Smith, Earl

1983-01-01

Summarizes and analyzes W.E.B. DuBois's publications on race and class, particularly as he observed the relationships between White and Black Americans from about 1890 to the 1960s. Contends that DuBois's work has been seriously underrated and cites William J. Wilson's work as corroborating and extending DuBois's theories. (CJM)

Toward the Development of a Canadian Less Lethal Weapon Approval Process: A Study of Contemporary Process Models

DTIC Science & Technology

2011-10-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011...validés par l’autorité d’approbation. Lorsqu’il n’existe pas de normes officielles, on utilise une approche de gestion du risque qui comprend une plus...gouvernance qui reprend les éléments clés du modèles du Royaume-Uni, l’incorporation d’un processus de gestion du risque, un énoncé des

Targeting, Air Force Doctrine Document 2-1.9

DTIC Science & Technology

2006-06-08

Target system analysis ( TSA ), as its name implies, approaches targets and target sets as systems to determine vulnerabilities and exploitable...weaknesses. Targeteers review how a functional target system works as a whole and analyze the interactions between components. TSA takes a system-of...effectiveness of target development. TSA begins in peacetime, before the commencement of conflict, and is accomplished with federated support and

Lippman photographs recorded in DuPont color photopolymer material

NASA Astrophysics Data System (ADS)

Bjelkhagen, Hans I.

1997-04-01

At the end of the last century, Gabriel Lippmann was experimenting with color photography. His photographic color recording technique, Lippmann photography, produced very beautiful photographs and the fact that the colors are preserved in the early Lippmann photographs indicates something about their archival properties. Recent progress in color reflection holography has made it possible to take a new look at this one hundred year old photographic technique. Today, high-resolution panchromatic recording materials suitable for Lippmann photography are on the market. In particular, the color photopolymers from DuPont have been investigated for modern Lippmann photography. Since the color photographs contain no dyes or pigments their archival stability may be high. In addition, a Lippmann photograph is difficult to copy which makes it a unique color photographic recording. Both of these features must attract a photographer interested in creating beautiful art photographs. Security application is another potential field for Lippmann photographs as well as optical filters. The dry processing of the photopolymer material is an important advantage. Another advantage is that no expensive equipment, such as lasers, is needed to explore this photographic recording technique; only a modified camera is required.

Un modèle mathématique décrivant le changement du caractère constitutif du sang dû à l'activation des plaquettes

NASA Astrophysics Data System (ADS)

Anand, Mohan; Rajagopal, Kumbakonam R.

Though a minor component by volume, platelets can have a profound influence on the flow characteristics of blood and thereby have serious consequences with regard to cardiovascular functions. Platelets are extremely sensitive to chemical agents as well as mechanical inputs and platelet activation is a necessary precursor to many life threatening medical conditions such as acute myocardial infarction, most strokes, acute arterial occlusion, venous thrombosis and pulmonary embolism. In cardiovascular devices such as ventricular assist devices and prosthetic heart valves, high shear stresses can trigger platelet activation. Moreover, such devices have artificial surfaces that are thrombogenic, the thrombotic deposition contributing to the failure of the device. Thus, there is a need to develop a mathematical model for the flow of blood that takes into account platelet activation, no such model being available at the moment. While there has been considerable amount of work in blood rheology, the role of platelets in the flow characteristics of blood has been largely ignored. This study addresses this lacuna. To cite this article: M. Anand, K.R. Rajagopal, C. R. Mecanique 330 (2002) 557-562.

In-house validation study of the DuPont Qualicon BAX system Q7 instrument with the BAX system PCR Assay for Salmonella (modification of AOAC Official Method 2003.09 and AOAC Research Institute Performance-Tested Method 100201).

PubMed

Tice, George; Andaloro, Bridget; White, H Kirk; Bolton, Lance; Wang, Siqun; Davis, Eugene; Wallace, Morgan

2009-01-01

In 2006, DuPont Qualicon introduced the BAX system Q7 instrument for use with its assays. To demonstrate the equivalence of the new and old instruments, a validation study was conducted using the BAX system PCR Assay for Salmonella, AOAC Official Method 2003.09, on three food types. The foods were simultaneously analyzed with the BAX system Q7 instrument and either the U.S. Food and Drug Administration Bacteriological Analytical Manual or the U.S. Department of Agriculture-Food Safety and Inspection Service Microbiology Laboratory Guidebook reference method for detecting Salmonella. Comparable performance between the BAX system and the reference methods was observed. Of the 75 paired samples analyzed, 39 samples were positive by both the BAX system and reference methods, and 36 samples were negative by both the BAX system and reference methods, demonstrating 100% correlation. Inclusivity and exclusivity for the BAX system Q7 instrument were also established by testing 50 Salmonella strains and 20 non-Salmonella isolates. All Salmonella strains returned positive results, and all non-Salmonella isolates returned a negative response.

Fluctuations quantiques et instabilites structurales dans les conducteurs a basse dimensionalite

NASA Astrophysics Data System (ADS)

Dikande, Alain Moise

Un engouement particulier s'est manifeste ces dernieres annees pour les systemes electroniques fortement correles, ce en rapport avec l'immense richesse de leurs proprietes physiques. En general, ces proprietes sont induites par la presence d'interactions entre electrons qui, combinees a la structure du reseau moleculaire, donnent parfois lieu a une tres grande variete de phases electroniques et structurales ayant des incidences directes sur les phenomenes de transport dans ces materiaux. Les systemes electroniques couples a un reseau moleculaire et designes systemes electron-phonon font partie de cette classe de materiaux qui ont recemment capte l'attention, en raison notamment de la competition entre plusieurs echelles d'energie dans un environnement caracterise par une forte anisotropie cristalline et une dynamique moleculaire assez importante. En effet, en plus des proprietes electroniques et structurales particulieres la dimensionalite de ces systemes contribue egalement a leur richesse. Ainsi, une tres forte anisotropie structurale peut rehausser de facon considerable l'importance des interactions entre electrons et entre molecules constituant le reseau au point ou la physique du systeme soit regie par de tres fortes fluctuations. Ce dernier contexte est devenu un domaine a part de la physique des systemes fortement correles, a savoir celui des les phenomenes critiques quantiques . Parmi les systemes electron-phonon, on retrouve les composes inorganique KCP et organique TTF-TCNQ decouverts durant les annees 70, et explores en profondeur a cause de leur tendance vers une instabilite du type onde de densite de charge a basse temperature. Ces composes, en general designes systemes de Peierls en reference a l'instabilite de leurs structures electroniques regie par le reseau moleculaire, ont recemment connu un regain d'interet a la lumiere des nouveaux developpements dans les techniques de caracterisation des structures electroniques ainsi que sur le plan de concepts tel le Liquide de Luttinger, propres aux systemes electroniques a une dimension. (Abstract shortened by UMI.)

INCORPORATING PRIOR KNOWLEDGE IN ENVIRONMENTAL SAMPLING: RANKED SET SAMPLING AND OTHER DOUBLE SAMPLING PROCEDURES

EPA Science Inventory

Environmental sampling can be difficult and expensive to carry out. Those taking the samples would like to integrate their knowledge of the system of study or their judgment about the system into the sample selection process to decrease the number of necessary samples. However,...

10 CFR 50.36 - Technical specifications.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., or component that is part of the primary success path and which functions or actuates to mitigate a... significant safety functions. Where a limiting safety system setting is specified for a variable on which a... the automatic safety system does not function as required, the licensee shall take appropriate action...

Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage

PubMed Central

Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; Abbassi, A.; Belmahi, A.M.

2011-01-01

Summary Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondaires à des brûlures électriques par haut voltage de diamètre allant de 8 à 11 cm et siégeant dans la région tonsurale. Ces patients ont été opérés dans la première semaine suivant l’accident. Les pertes de substance du scalp de taille moyenne secondaires à ces brûlures peuvent être couvertes per primam de façon fiable par des lambeaux locaux axialisés et multiples. Nous relatons l’expérience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc, dans la gestion et la prise en charge de ces brûlures. PMID:22262963

The brain is a target organ after acute exposure to depleted uranium.

PubMed

Lestaevel, P; Houpert, P; Bussy, C; Dhieux, B; Gourmelon, P; Paquet, F

2005-09-01

The health effects of depleted uranium (DU) are mainly caused by its chemical toxicity. Although the kidneys are the main target organs for uranium toxicity, uranium can also reach the brain. In this paper, the central effects of acute exposure to DU were studied in relation to health parameters and the sleep-wake cycle of adult rats. Animals were injected intraperitoneally with 144+/-10 microg DU kg-1 as nitrate. Three days after injection, the amounts of uranium in the kidneys represented 2.6 microg of DU g-1 of tissue, considered as a sub-nephrotoxic dosage. The central effect of uranium could be seen through a decrease in food intake as early as the first day after exposure and shorter paradoxical sleep 3 days after acute DU exposure (-18% of controls). With a lower dosage of DU (70+/-8 microg DU kg-1), no significant effect was observed on the sleep-wake cycle. The present study intends to illustrate the fact that the brain is a target organ, as are the kidneys, after acute exposure to a moderate dosage of DU. The mechanisms by which uranium causes these early neurophysiological perturbations shall be discussed.

How diet and lifestyle affect duodenal ulcers. Review of the evidence.

PubMed Central

Ryan-Harshman, Milly; Aldoori, Walid

2004-01-01

OBJECTIVE: To demonstrate the role of diet in reducing or aggravating risk of duodenal ulcer (DU). QUALITY OF EVIDENCE: MEDLINE was searched from January 1966 to December 2001 for articles on the relationship between diet and lifestyle and DU using the key words duodenal ulcer and diet, fibre, or lifestyle. Evidence that these factors are associated with DU arose mainly from three case-control and three prospective studies (level II evidence) and from expert opinion (level III evidence). MAIN MESSAGE: A high-fibre diet appears to reduce risk of DU; soluble fibre might be associated with reduced risk also. Vitamin A intake is associated with lower risk of DU. Little evidence indicates that fat, type of fat, protein intake, or consumption of alcohol or caffeine affect the etiology of DU. CONCLUSION: A high-fibre diet, particularly if the fibre comes from fruit and vegetables, could reduce risk of DU; vitamin A might also be beneficial. PMID:15171675

Hématome spontané du méso de l'angle colique droit et du colon transverse compliquant un traitement par anti vitamine K: à propos d'un cas et revue de la littérature

PubMed Central

Traoré, Ibrahim Alain; Zaré, Cyprien; Barro, Sié Drissa; Guibla, Ismaël

2016-01-01

L'hématome spontané du méso de l'angle colique droit et du transverse est une complication rare du traitement anticoagulant par antivitamine K. Nous rapportons un cas d'hématome spontané du méso de l'angle colique droit et du transverse associé à un hémopéritoine de grande abondance chez un patient traité par antivitamine K pour embolie pulmonaire consécutive à une fracture des plateaux tibiaux droits. Le diagnostic doit être fait en urgence. L’échographie abdominale et la tomodensitométrie confirment le diagnostic. Le traitement non opératoire est la règle. Le traitement chirurgical est indiqué en cas de complications telles que la rupture de l'hématome. PMID:27217878

Environmental acceptability of high-performance alternatives for depleted uranium penetrators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerley, C.R.; Easterly, C.E.; Eckerman, K.F.

1996-08-01

The Army`s environmental strategy for investigating material substitution and management is to measure system environmental gains/losses in all phases of the material management life cycle from cradle to grave. This study is the first in a series of new investigations, applying material life cycle concepts, to evaluate whether there are environmental benefits from increasing the use of tungsten as an alternative to depleted uranium (DU) in Kinetic Energy Penetrators (KEPs). Current military armor penetrators use DU and tungsten as base materials. Although DU alloys have provided the highest performance of any high-density alloy deployed against enemy heavy armor, its low-levelmore » radioactivity poses a number of environmental risks. These risks include exposures to the military and civilian population from inhalation, ingestion, and injection of particles. Depleted uranium is well known to be chemically toxic (kidney toxicity), and workplace exposure levels are based on its renal toxicity. Waste materials containing DU fragments are classified as low-level radioactive waste and are regulated by the Nuclear Regulatory Commission. These characteristics of DU do not preclude its use in KEPs. However, long-term management challenges associated with KEP deployment and improved public perceptions about environmental risks from military activities might be well served by a serious effort to identify, develop, and substitute alternative materials that meet performance objectives and involve fewer environmental risks. Tungsten, a leading candidate base material for KEPS, is potentially such a material because it is not radioactive. Tungsten is less well studied, however, with respect to health impacts and other environmental risks. The present study is designed to contribute to the understanding of the environmental behavior of tungsten by synthesizing available information that is relevant to its potential use as a penetrator.« less

Watershed Data Management (WDM) Database for Salt Creek Streamflow Simulation, DuPage County, Illinois

USGS Publications Warehouse

Murphy, Elizabeth A.; Ishii, Audrey L.

2006-01-01

The U.S. Geological Survey (USGS), in cooperation with DuPage County Department of Engineering, Stormwater Management Division, maintains a database of hourly meteorologic and hydrologic data for use in a near real-time streamflow simulation system, which assists in the management and operation of reservoirs and other flood-control structures in the Salt Creek watershed in DuPage County, Illinois. The majority of the precipitation data are collected from a tipping-bucket rain-gage network located in and near DuPage County. The other meteorologic data (wind speed, solar radiation, air temperature, and dewpoint temperature) are collected at Argonne National Laboratory in Argonne, Illinois. Potential evapotranspiration is computed from the meteorologic data. The hydrologic data (discharge and stage) are collected at USGS streamflow-gaging stations in DuPage County. These data are stored in a Watershed Data Management (WDM) database. This report describes a version of the WDM database that was quality-assured and quality-controlled annually to ensure the datasets were complete and accurate. This version of the WDM database contains data from January 1, 1997, through September 30, 2004, and is named SEP04.WDM. This report provides a record of time periods of poor data for each precipitation dataset and describes methods used to estimate the data for the periods when data were missing, flawed, or snowfall-affected. The precipitation dataset data-filling process was changed in 2001, and both processes are described. The other meteorologic and hydrologic datasets in the database are fully described in the annual U.S. Geological Survey Water Data Report for Illinois and, therefore, are described in less detail than the precipitation datasets in this report.

Characterization of Blistering and Delamination in Depleted Uranium Hohlraums

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biobaum, K. J. M.

2013-03-01

Blistering and delamination are the primary failure mechanisms during the processing of depleted uranium (DU) hohlraums. These hohlraums consist of a sputter-deposited DU layer sandwiched between two sputter-deposited layers of gold; a final thick gold layer is electrodeposited on the exterior. The hohlraum is deposited on a copper-coated aluminum mandrel; the Al and Cu are removed with chemical etching after the gold and DU layers are deposited. After the mandrel is removed, blistering and delamination are observed on the interiors of some hohlraums, particularly at the radius region. It is hypothesized that blisters are caused by pinholes in the coppermore » and gold layers; etchant leaking through these holes reaches the DU layer and causes it to oxidize, resulting in a blister. Depending on the residual stress in the deposited layers, blistering can initiate larger-scale delamination at layer interfaces. Scanning electron microscopy indicates that inhomogeneities in the machined aluminum mandrel are replicated in the sputter-deposited copper layer. Furthermore, the Cu layer exhibits columnar growth with pinholes that likely allow etchant to come in contact with the gold layer. Any inhomogeneities or pinholes in this initial gold layer then become nucleation sites for blistering. Using a focused ion beam system to etch through the gold layer and extract a cross-sectional sample for transmission electron microscopy, amorphous, intermixed layers at the gold/DU interfaces are observed. Nanometer-sized bubbles in the sputtered and electrodeposited gold layers are also present. Characterization of the morphology and composition of the deposited layers is the first step in determining modifications to processing parameters, with the goal of attaining a significant improvement in hohlraum yield.« less

Radiological Risk Assessment of Capstone Depleted Uranium Aerosols

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hahn, Fletcher; Roszell, Laurie E.; Daxon, Eric G.

2009-02-26

Assessment of the health risk from exposure to aerosols of depleted uranium (DU) is an important outcome of the Capstone aerosol studies that established exposure ranges to personnel in armored combat vehicles perforated by DU munitions. Although the radiation exposure from DU is low, there is concern that DU deposited in the body may increase cancer rates. Radiation doses to various organs of the body resulting from the inhalation of DU aerosols measured in the Capstone studies were calculated using International Commission on Radiological Protection (ICRP) models. Organs and tissues with the highest calculated committed equivalent 50-yr doses were lungmore » and extrathoracic tissues (nose and nasal passages, pharynx, larynx, mouth and thoracic lymph nodes). Doses to the bone surface and kidney were about 5 to 10% of the doses to the extrathoracic tissues. The methodologies of the ICRP International Steering Committee on Radiation Standards (ISCORS) were used for determining the whole body cancer risk. Organ-specific risks were estimated using ICRP and U.S. Environmental Protection Agency (EPA) methodologies. Risks for crewmembers and first responders were determined for selected scenarios based on the time interval of exposure and for vehicle and armor type. The lung was the organ with the highest cancer mortality risk, accounting for about 97% of the risks summed from all organs. The highest mean lifetime risk for lung cancer for the scenario with the longest exposure time interval (2 h) was 0.42%. This risk is low compared with the natural or background risk of 7.35%. These risks can be significantly reduced by using an existing ventilation system (if operable) and by reducing personnel time in the vehicle immediately after perforation.« less

Potentiometric Surfaces and Changes in Groundwater Levels in Selected Bedrock Aquifers in the Twin Cities Metropolitan Area, March-August 2008 and 1988-2008

USGS Publications Warehouse

Sanocki, Christopher A.; Langer, Susan K.; Menard, Jason C.

2008-01-01

This report depicts potentiometric surfaces and groundwater- level changes in three aquifers that underlie the seven-county Twin Cities Metropolitan Area. Approximately 350 groundwater levels were measured in wells from the three aquifers-the Prairie du Chien-Jordan, the Franconia-Ironton-Galesville, and the Mount Simon-Hinckley aquifers-in March and August of 2008. The report presents maps, associated data tables, and 22 geographic information system datasets. The maps presented in this report show the potentiometric surfaces in March and August of 2008 for all three aquifers, groundwater-level changes from March to August 2008 for each aquifer, and revised potentiometric-surface contours for the winter of 1988-89 for the Prairie du Chien-Jordan and the Mount Simon-Hinckley aquifers, and the estimated long-term (winter of 1988-89 to March 2008) groundwater-level changes for the Prairie du Chien-Jordan and Mount Simon-Hinckley aquifers. This report documents the methods used to construct the maps and provides a context for the period of the measurements. Although withdrawal demand is increasing in the Twin Cities Metropolitan area, particularly in the Prairie du Chien-Jordan aquifer, year-to-year changes in withdrawals can be substantial, and the relation between potentiometric surfaces in the major aquifers and year-to-year withdrawals is not well established. The estimated long-term (19-year) groundwater-level changes for the Prairie du Chien-Jordan and Mount Simon-Hinckley aquifers have not been large based on data and maps produced during this study, despite the large seasonal fluctuations shown by the March and August 2008 synoptic measurements.

Stability and Control of Tactical Missile Systems Held in Ankara (Turkey) on 9-12 May 1988

DTIC Science & Technology

1989-03-01

basic body for the systematic tests consisted of a cylindrical body with an ogive nose 3.0 calibers long for a total body length of 12.5 calibers A...Portance et stabilittd d’un Aiulege (ogies / iei 4 cylindre ) A N - 2.8. Compareison celcul "Euler" eec 1 d~~w~~hR~~t -- x~ine CALCUL -EULERV OPUP...toujours repr~sentatifs de Ia r~alit6. Compte tenu des pr~cisions recher- ch~es, lea effets du montage, d’un jet propulsif, du nombre de Reynolds, ou de

New Advanced Mass Casualty Breathing System for Oxygen Therapy: Phase 1

DTIC Science & Technology

2006-10-01

of National Defence, 2006 © Sa Majesté la Reine , représentée par le ministre de la Défense nationale, 2006 DRDC Toronto TM 2006-201 i...Toronto a été chargé d’examiner la performance du masque PulmanexMD Hi-OxMD (Hi-Ox) à des débits d’oxygène (O2) de 4 litres par minute (L·min-1) en...d’examiner la performance du masque PulmanexMD Hi-OxMD (Hi-Ox) à des débits d’oxygène (O2) de 4 litres par minute (L·min-1). Le masque Hi-Ox est un

Command and Control (C2) Agility (Agilite du commandement et du controle (C2))

DTIC Science & Technology

2014-10-01

de la rigueur et de l’emploi des méthodes de mesure et d’amélioration de l’agilité du C2. Le spectre des missions... Control and Intelligence (C2I) Section DRDC Valcartier 2459 de la Bravoure Road Québec (Québec) G3J 1X5 CANADA Email: Micheline.Belanger@drdc...Agilité du commandement et du contrôle (C2) (STO-TR-SAS-085) Synthèse L’agilité est la capacité à effectuer avec succès, s’occuper de

Dynamique d'un oscillateur photoréfractif : instabilités et analogie avec la loi de Curie-Weiss

NASA Astrophysics Data System (ADS)

Mathey, P.; Odoulov, S. G.; Rytz, D.

2002-06-01

La dynamique et l'état stationnaire du faisceau issu d'une cavité oscillante comprenant un cristal non-linéaire de titanate de baryum utilisé en tant que miroir à conjugaison de phase sont étudiés. Le paramètre du système étant le gain du milieu non-linéaire, les dépendances de l'intensité de l'oscillation et de l'inverse du temps de réponse sont similaires aux lois de Curie en physique du solide.

Les traces matérielles de la Carte du Ciel. Le cas des observatoires d'Alger et de Bordeaux.

NASA Astrophysics Data System (ADS)

Le Guet Tully, F.; Davoigneau, J.; Lamy, J.; de La Noë, J.; Rousseau, J.-M.; Sadsaoud, H.

2008-06-01

Le chapitre évoque les traces matérielles de la Carte du ciel subsistant dans les observatoires d'Alger et de Bordeaux. Les auteurs examinent d'abord l'opération d'inventaire du patrimoine astronomique entreprise à partir du milieu des années 1990. Ils examinent ensuite les éléments concrets constituant aujourd'hui le patrimoine de la Carte du Ciel : lunettes, abris, accessoires, laboratoires, réseaux, plaques de verre, registres, machines à mesurer les clichés, et cartes.

Volcanic-aerosol-induced changes in stratospheric ozone following the eruption of Mount Pinatubo

NASA Technical Reports Server (NTRS)

Grant, W. B.; Browell, E. V.; Fishman, J.; Brackett, V. G.; Fenn, M. A.; Butler, C. F.; Nganga, D.; Minga, A.; Cros, B.; Mayor, S. D.

1994-01-01

Measurements of lower stratospheric ozone in the Tropics using electrochemical concentrations cell (ECC) sondes and the airborne UV Differential Absorption Lidar (DIAL) system after the eruption of Mt. Pinatubo are compared with the Stratospheric Aerosol and Gas Experiment 2 (SAGE 2) and ECC sonde measurements from below the eruption to determine what changes have occurred as a result. Aerosol data from the Advanced Very High Resolution Radiometer (AVHRR) and the visible and IR wavelengths of the lidar system are used to examine the relationship between aerosols and ozone changes. Ozone decreases of 30 percent at altitudes between 19 and 26 km, partial column (16-28 km) decreases of about 27 D.U., and slight increases (5.4 D.U.) between 28 and 31 km are found in comparison with SAGE 2 climatological values.

Global integrated drought monitoring and prediction system

PubMed Central

Hao, Zengchao; AghaKouchak, Amir; Nakhjiri, Navid; Farahmand, Alireza

2014-01-01

Drought is by far the most costly natural disaster that can lead to widespread impacts, including water and food crises. Here we present data sets available from the Global Integrated Drought Monitoring and Prediction System (GIDMaPS), which provides drought information based on multiple drought indicators. The system provides meteorological and agricultural drought information based on multiple satellite-, and model-based precipitation and soil moisture data sets. GIDMaPS includes a near real-time monitoring component and a seasonal probabilistic prediction module. The data sets include historical drought severity data from the monitoring component, and probabilistic seasonal forecasts from the prediction module. The probabilistic forecasts provide essential information for early warning, taking preventive measures, and planning mitigation strategies. GIDMaPS data sets are a significant extension to current capabilities and data sets for global drought assessment and early warning. The presented data sets would be instrumental in reducing drought impacts especially in developing countries. Our results indicate that GIDMaPS data sets reliably captured several major droughts from across the globe. PMID:25977759

Global integrated drought monitoring and prediction system.

PubMed

Hao, Zengchao; AghaKouchak, Amir; Nakhjiri, Navid; Farahmand, Alireza

2014-01-01

Drought is by far the most costly natural disaster that can lead to widespread impacts, including water and food crises. Here we present data sets available from the Global Integrated Drought Monitoring and Prediction System (GIDMaPS), which provides drought information based on multiple drought indicators. The system provides meteorological and agricultural drought information based on multiple satellite-, and model-based precipitation and soil moisture data sets. GIDMaPS includes a near real-time monitoring component and a seasonal probabilistic prediction module. The data sets include historical drought severity data from the monitoring component, and probabilistic seasonal forecasts from the prediction module. The probabilistic forecasts provide essential information for early warning, taking preventive measures, and planning mitigation strategies. GIDMaPS data sets are a significant extension to current capabilities and data sets for global drought assessment and early warning. The presented data sets would be instrumental in reducing drought impacts especially in developing countries. Our results indicate that GIDMaPS data sets reliably captured several major droughts from across the globe.

Adsorption de gaz sur les materiaux microporeux modelisation, thermodynamique et applications

NASA Astrophysics Data System (ADS)

Richard, Marc-Andre

2009-12-01

Nos travaux sur l'adsorption de gaz dans les materiaux microporeux s'inscrivent dans le cadre des recherches visant a augmenter l'efficacite du stockage de l'hydrogene a bord des vehicules. Notre objectif etait d'etudier la possibilite d'utiliser l'adsorption afin d'ameliorer l'efficacite de la liquefaction de l'hydrogene des systemes a petite echelle. Nous avons egalement evalue les performances d'un systeme de stockage cryogenique de l'hydrogene base sur la physisorption. Comme nous avons affaire a des plages de temperatures particulierement etendues et a de hautes pressions dans la region supercritique du gaz, nous avons du commencer par travailler sur la modelisation et la thermodynamique de l'adsorption. La representation de la quantite de gaz adsorbee en fonction de la temperature et de la pression par un modele semi-empirique est un outil utile pour determiner la masse de gaz adsorbee dans un systeme mais egalement pour calculer les effets thermiques lies a l'adsorption. Nous avons adapte le modele Dubinin-Astakhov (D-A) pour modeliser des isothermes d'adsorption d'hydrogene, d'azote et de methane sur du charbon actif a haute pression et sur une grande plage de temperatures supercritiques en considerant un volume d'adsorption invariant. Avec cinq parametres de regression (incluant le volume d'adsorption Va), le modele que nous avons developpe permet de tres bien representer des isothermes experimentales d'adsorption d'hydrogene (de 30 a 293 K, jusqu'a 6 MPa), d'azote (de 93 a 298 K, jusqu'a 6 MPa) et de methane (de 243 a 333 K, jusqu'a 9 MPa) sur le charbon actif. Nous avons calcule l'energie interne de la phase adsorbee a partir du modele en nous servant de la thermodynamique des solutions sans negliger le volume d'adsorption. Par la suite, nous avons presente les equations de conservation de la niasse et de l'energie pour un systeme d'adsorption et valide notre demarche en comparant des simulations et des tests d'adsorption et de desorption. En plus de l'energie interne, nous avons evalue l'entropie, l'energie differentielle d'adsorption et la chaleur isosterique d'adsorption. Nous avons etudie la performance d'un systeme de stockage d'hydrogene par adsorption pour les vehicules. La capacite de stockage d'hydrogene et les performances thermiques d'un reservoir de 150 L contenant du charbon actif Maxsorb MSC-30(TM) (surface specifique ˜ 3000 m2/g) ont ete etudiees sur une plage de temperatures de 60 a 298 K et a des pressions allant jusqu'a 35 MPa. Le systeme a ete considere de facon globale, sans nous attarder a un design particulier. Il est possible de stocker 5 kg d'hydrogene a des pressions de 7.8, 15.2 et 29 MPa pour des temperatures respectivement de 80, 114 et 172 K, lorsqu'on recupere l'hydrogene residuel a 2.5 bars en le chauffant. La simulation des phenomenes thermiques nous a permis d'analyser le refroidissement necessaire lors du remplissage, le chauffage lors de la decharge et le temps de dormance. Nous avons developpe un cycle de liquefaction de l'hydrogene base sur l'adsorption avec compression mecanique (ACM) et avons evalue sa faisabilite. L'objectif etait d'augmenter sensiblement l'efficacite des systemes de liquefaction de l'hydrogene a petite echelle (moins d'une tonne/jour) et ce, sans en augmenter le cout en capital. Nous avons adapte le cycle de refrigeration par ACM afin qu'il puisse par la suite etre ajoute a un cycle de liquefaction de l'hydrogene. Nous avons ensuite simule des cycles idealises de refrigeration par ACM. Meme dans ces conditions ideales, la refrigeration specifique est faible. De plus, l'efficacite theorique maximale de ces cycles de refrigeration est d'environ 20 a 30% de l'ideal. Nous avons realise experimentalement un cycle de refrigeration par ACM avec le couple azote/charbon actif. (Abstract shortened by UMI.)

CATS Featured Articles

Atmospheric Science Data Center

2017-01-31

... Transport System (CATS) onboard the International Space Station. Nighttime View of Raung Volcanic Plume : Natural Hazards ... Eastern Hemisphere: Image of the Day  -  Three more missions are set to take off in the next six months: the wind-measuring ...

Visualizing planetary data by using 3D engines

NASA Astrophysics Data System (ADS)

Elgner, S.; Adeli, S.; Gwinner, K.; Preusker, F.; Kersten, E.; Matz, K.-D.; Roatsch, T.; Jaumann, R.; Oberst, J.

2017-09-01

We examined 3D gaming engines for their usefulness in visualizing large planetary image data sets. These tools allow us to include recent developments in the field of computer graphics in our scientific visualization systems and present data products interactively and in higher quality than before. We started to set up the first applications which will take use of virtual reality (VR) equipment.

Contextualizing an Expanded Definition of Health Literacy among Adolescents in the Health Care Setting

ERIC Educational Resources Information Center

Massey, Philip M.; Prelip, Michael; Calimlim, Brian M.; Quiter, Elaine S.; Glik, Deborah C.

2012-01-01

The current emphasis on preventive health care and wellness services suggests that measures of skills and competencies needed to effectively navigate the health care system need to be better defined. We take an expanded perspective of health literacy and define it as a set of skills used to organize and apply health knowledge, attitudes and…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guilmette, Ray A.; Hahn, Fletcher F.; Durbin, P. W.

A number of U. S. veterans of the Persian Gulf War were wounded with depleted uranium (DU) metal fragments as a result of 'friendly fire' incidents, in which Abrams tanks and Bradley fighting vehicles were struck by DU anti-armor munitions. Some of the crew members who survived were left with multiple small fragments of DU in their muscles and soft tissues. The number, size and location of the fragments made them inoperable in general, and therefore subject to long-term retention. Because there was inadequate data to predict the potential carcinogenicity of DU fragments in soft tissues, Hahn et al. (2003)more » conducted a lifespan cancer study in rats. As part of that study, a number of rats were maintained to study the biokinetics and dosimetry of DU implanted intramuscularly in male Wistar rats. Typically, four metal fragments, either as cylindrical pellets or square wafers were implanted into the biceps femoris muscles of the rats. Urine samples were collected periodically during their lifespans, and DU was analyzed in kidneys and eviscerated carcass (minus the implant sites) at death. The daily DU urinary excretion rate increased steeply during the first 30 d after implantation peaking at about 90 d at 3-10 x 10{sup -3}%/d. During the first 150 d, the average excretion rate was 2.4 x 10{sup -3}%/d, decreasing thereafter to about 1 x 10{sup -3}%/d. Serial radiographs were made of the wound sites to monitor gross morphologic changes in the DU implant and the surrounding tissue. As early as 1 w after implantation, radiographs showed the presence of surface corrosion and small, dense bodies near the original implant, presumably DU. This corrosion from the surface of the implant continued with time, but did not result in an increasing amount of DU reaching the blood and urine after the first 3 mo. During this 3-mo period, connective tissue capsules formed around the implants, and are hypothesized to have reduced the access of DU to tissue fluids by limiting the diffusion rate of dissolved chemical forms of DU. Using a model of wound-site retention being developed by a committee of the U.S. National Council of Radiation Protection and Measurements (NCRP), it was found that the average retention of DU in the wound site could be described by a two-component exponential function in which 0.5% of the DU was retained with a half time of 80 d and the remainder with a half time of about 300 y.« less

Coalition Battle Management Language (C-BML) (Language de gestion du champ de bataille (C-BML)

DTIC Science & Technology

2012-02-01

de gestion du champ de bataille (C-BML)) NMSG-048 Final Report. This document...BML) (Langage de gestion du champ de bataille (C-BML)) NMSG-048 Final Report. This document contains information authorized by NATO RTA for...Technical Readiness Level (TRL) that is consistent with an operational deployment. ES - 2 RTO-TR-MSG-048 Langage de gestion du champ de

Characterization of Depleted-Uranium Strength and Damage Behavior

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gray, III, George T.; Chen, Shuh-Rong; Bronkhorst, Curt A.

2012-12-17

The intent of this report is to document the status of our knowledge of the mechanical and damage behavior of Depleted Uranium(DU hereafter). This report briefly summaries the motivation of the experimental and modeling research conducted at Los Alamos National Laboratory(LANL) on DU since the early 1980’s and thereafter the current experimental data quantifying the strength and damage behavior of DU as a function of a number of experimental variables including processing, strain rate, temperature, stress state, and shock prestraining. The effect of shock prestraining on the structure-property response of DU is described and the effect on post-shock mechanical behaviormore » of DU is discussed. The constitutive experimental data utilized to support the derivation of two constitutive strength (plasticity) models, the Preston-Tonks-Wallace (PTW) and Mechanical Threshold Stress (MTS) models, for both annealed and shock prestrained DU are detailed and the Taylor cylinder validation tests and finite-element modeling (FEM) utilized to validate these strength models is discussed. The similarities and differences in the PTW and MTS model descriptions for DU are discussed for both the annealed and shock prestrained conditions. Quasi-static tensile data as a function of triaxial constraint and spallation test data are described. An appendix additionally briefly describes low-pressure equation-of-state data for DU utilized to support the spallation experiments. The constitutive behavior of DU screw/bolt material is presented. The response of DU subjected to dynamic tensile extrusion testing as a function of temperature is also described. This integrated experimental technique is planned to provide an additional validation test in the future. The damage data as a function of triaxiality, tensile and spallation data, is thereafter utilized to support derivation of the Tensile Plasticity (TEPLA) damage model and simulations for comparison to the DU spallation data are presented. Finally, a discussion of future needs in the area of needed DU strength and damage research at LANL is presented to support the development of physically-based predictive strength and damage modeling capability.« less

Evaluation of the effect of implanted depleted uranium on male reproductive success, sperm concentration, and sperm velocity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arfsten, Darryl P.; Schaeffer, David J.; Johnson, Eric W.

Depleted uranium (DU) projectiles have been used in battle in Iraq and the Balkans and will continue to be a significant armor-penetrating munition for the US military. As demonstrated in the Persian Gulf War, battle injury from DU projectiles and shrapnel is a possibility, and removal of embedded DU fragments from the body is not always practical because of their location in the body or their small size. Previous studies in rodents have demonstrated that implanted DU mobilizes and translocates to the gonads, and natural uranium may be toxic to spermatazoa and the male reproductive tract. In this study, themore » effects of implanted DU pellets on sperm concentration, motility, and male reproductive success were evaluated in adult (P1) Sprague-Dawley rats implanted with 0, 12, or 20, DU pellets of 1x2 mm or 12 or 20 tantalum (Ta) steel pellets of 1x2 mm. Twenty DU pellets of 1x2 mm (760 mg) implanted in a 500-g rat are equal to approximately 0.2 pound of DU in a 154-lb (70-kg) person. Urinary analysis found that male rats implanted with DU were excreting uranium at postimplantation days 27 and 117 with the amount dependent on dose. No deaths or evidence of toxicity occurred in P1 males over the 150-day postimplantation study period. When assessed at postimplantation day 150, the concentration, motion, and velocity of sperm isolated from DU-implanted animals were not significantly different from those of sham surgery controls. Velocity and motion of sperm isolated from rats treated with the positive control compound {alpha}-chlorohydrin were significantly reduced compared with sham surgery controls. There was no evidence of a detrimental effect of DU implantation on mating success at 30-45 days and 120-145 days postimplantation. The results of this study suggest that implantation of up to 20 DU pellets of 1x2 mm in rats for approximately 21% of their adult lifespan does not have an adverse impact on male reproductive success, sperm concentration, or sperm velocity.« less

School Exchanges Present and Future. Proceedings of the Symposium (Barcelona, Spain, March 13-17, 1991) = Bilan et Perspectives des Echanges Scolaires. Actes du colloque (Barcelone, Spain, 13-17 mar 1991).

ERIC Educational Resources Information Center

Commission of the European Communities, Brussels (Belgium).

This document sets forth the proceedings of a symposium on the subject of international educational exchanges. Part 1 of the document includes introductory remarks by Catalonia's minister of education and David Coyne of the European Commission's task force on human relations. Part 2 offers specific introductory material on political, theoretical,…

Face Recognition and Event Detection in Video: An Overview of PROVE-IT Projects

DTIC Science & Technology

2014-07-01

with Public Safety Canada. Led by Canada Border Services Agency partners included : Royal Canadian Mounted Police, Defence Research Development Canada...represented by the Minister of National Defence, 2014 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense...each of these settings. As secondary outputs, the projects produced technology demonstrations, refereed publications , and an alternative assessment

Cancer du sein au Maroc: profil phénotypique des tumeurs

PubMed Central

Khalil, Ahmadaye Ibrahim; Bendahhou, Karima; Mestaghanmi, Houriya; Saile, Rachid; Benider, Abdellatif

2016-01-01

Le cancer du sein est le plus fréquent chez la femme et figure parmi les principales causes de mortalité liées au cancer. La curabilité de ce type tumoral est en augmentation, grâce aux programmes de dépistage et aux progrès thérapeutiques, qui ont certes augmenté la survie des patients. Mais des défis restent à relever en rapport avec l’instabilité phénotypique des cellules cancéreuses. L’objectif de ce travail est d’étudier le profil phénotypique du cancer du sein chez les patients pris en charge au Centre Mohammed VI pour le traitement des Cancers, durant les années 2013-2014. Il s’agit d’une étude transversale sur deux années, incluant les cas du cancer du sein pris en charge au Centre. Le recueil des données était fait à partir des dossiers des patients et analysés par le logiciel Epi Info. 1277 patients ont été pris en charge au sein de notre centre. 99,5% des cas de sexe féminin, l’âge moyen était 50,20 ± 11,34 ans. Le type histologique le plus fréquent était le carcinome canalaire infiltrant (80,7% des cas). Le stade diagnostic était précoce (56,9%). Le phénotype moléculaire le plus fréquent était le luminal A (41,4% des cas). Le luminal B, le HER2 et les triples négatifs étaient dans respectivement 10,4%, 6,3%, 11,2% des cas. L’étude du phénotype tumoral des patients atteints du cancer du sein permet l’orientation du clinicien dans le choix du traitement, et des décideurs dans la planification de programmes de lutte contre cette pathologie. PMID:28292037

Polymorphisme de l'apolipoprotéine E dans la population du nord du Maroc: fréquence et influence sur les paramètres lipidiques

PubMed Central

Benyahya, Fatiha; Barakat, Amina; Ghailani, Naima; Bennani, Mohcine

2013-01-01

Introduction L'objectif de ce travail est de déterminer les fréquences alléliques et génotypiques des sites polymorphes situés dans le gène de l'apolipoprotéine E (apo E) ainsi que leur impact sur les paramètres cliniques et lipidiques dans un échantillon de la population du nord du Maroc cliniquement diagnostiqué ADH. Méthodes Le génotype de l'apo E a été analysé par séquençage direct chez 46 patients cliniquement diagnostiqués ADH selon les critères standards. Résultats Les fréquences des allèles epsilon 3, epsilon 2 et epsilon 4 ont été respectivement 78.3%, 2.2% et 19.6%. La fréquence de l'allèle epsilon 4 est très élevée chez la population du nord du Maroc en comparaison avec les populations des autres régions marocaines. Elle est similaire à celle rapportée dans les pays de l'Europe du nord. Les taux du cholestérol total, du cholestérol LDL ainsi que la présence des xanthomes et les maladies cardiovasculaires ne différent pas entre les génotypes de l'apoE. En revanche, les résultats ont montré une influence de l'allèle epsilon4 sur le taux des triglycérides chez les sujets obèses. Conclusion Le génotype de l'apoE ne peut expliquer le phénotype clinique et biochimique présenté par des patients du Nord du Maroc cliniquement diagnostiqués ADH. PMID:24396563

Lifelong obesity in a polygenic mouse model prevents age- and diet-induced glucose intolerance- obesity is no road to late-onset diabetes in mice.

PubMed

Renne, Ulla; Langhammer, Martina; Brenmoehl, Julia; Walz, Christina; Zeissler, Anja; Tuchscherer, Armin; Piechotta, Marion; Wiesner, Rudolf J; Bielohuby, Maximilian; Hoeflich, Andreas

2013-01-01

Visceral obesity holds a central position in the concept of the metabolic syndrome characterized by glucose intolerance in humans. However, until now it is unclear if obesity by itself is responsible for the development of glucose intolerance. We have used a novel polygenic mouse model characterized by genetically fixed obesity (DU6) and addressed age- and high fat diet-dependent glucose tolerance. Phenotype selection over 146 generations increased body weight by about 2.7-fold in male 12-week DU6 mice (P<0.0001) if compared to unselected controls (Fzt:DU). Absolute epididymal fat mass was particularly responsive to weight selection and increased by more than 5-fold (P<0.0001) in male DU6 mice. At an age of 6 weeks DU6 mice consumed about twice as much food if compared to unselected controls (P<0.001). Absolute food consumption was higher at all time points measured in DU6 mice than in Fzt:DU mice. Between 6 and 12 weeks of age, absolute food intake was reduced by 15% in DU6 mice (P<0.001) but not in Fzt:DU mice. In both mouse lines feeding of the high fat diet elevated body mass if compared to the control diet (P<0.05). In contrast to controls, DU6 mice did not display high fat diet-induced increases of epididymal and renal fat. Control mice progressively developed glucose intolerance with advancing age and even more in response to the high fat diet. In contrast, obese DU6 mice did neither develop a glucose intolerant phenotype with progressive age nor when challenged with a high fat diet. Our results from a polygenic mouse model demonstrate that genetically pre-determined and life-long obesity is no precondition of glucose intolerance later in life.

Investigation de l'anisotropie du gap supraconducteur dans les composes Ba(Fe(1-x)Co(x))2As2, Ba(1-x)K(x)Fe2As2, LiFeAs et Fe1-deltaTe(1-x)Se(x)

NASA Astrophysics Data System (ADS)

Reid, Jean-Philippe

ommaire La structure du gap supraconducteur et sa modulation sont intimement liees au potentiel d'interaction responsable de l'appariement des electrons d'un supraconducteur. Ainsi, l'etude de la structure du gap-SC et de sa modulation permettent de faire la lumiere sur la nature du mecanisme d'appariement des electrons. A cet egard, les resultats experimentaux des supraconducteurs a base de fer ne cadrent pas dans un seul ensemble, ce qui est en opposition au gap-SC universel des cuprates. Dans ce qui suit, nous presenterons une etude systematique du gap-SC pour plusieurs pnictides. En effet, en utilisant la conductivite thermique, une sonde directionnelle du gap-SC, nous avons ete en mesure de reveler la structure du gap-SC pour les composes suivants : Ba1-xKxFe 2As2, Ba(Fe1-xCo x)2As2, LiFeAs et Fe1-deltaTe 1-xSex. L'etude de ces quatre composes, de trois differentes familles structurales, a pu etablir un tableau partiel mais tres exhaustif de la structure du gap-SC de pnictides. En effet, tel qu'illustre dans cette these, ces quatre composes ne possedent aucun noeud dans leur structure du gap-SC a dopage optimal. Toutefois, a une concentration differente de celle optimale pour les composes K-Ba122 et Co-Ba122, des noeuds apparaissent sur la surface de Fermi, aux extremites 'du dome supraconducteur. Ceci suggere fortement que, pour ces composes, la presence de noeuds sur la surface de Fermi est nuisible a la phase supraconductrice. Mots-cles: Supraconducteurs a base de fer, Pnictides, Structure du gap supraconducteur, Conductivite thermique

MyOcean Central Information System - Achievements and Perspectives

NASA Astrophysics Data System (ADS)

Claverie, Vincent; Loubrieu, Thomas; Jolibois, Tony; de Dianous, Rémi; Blower, Jon; Romero, Laia; Griffiths, Guy

2013-04-01

Since 2009, MyOcean (http://www.myocean.eu) is providing an operational service, for forecasts, analysis and expertise on ocean currents, temperature, salinity, sea level, primary ecosystems and ice coverage. The production of observation and forecasting data is done by 42 Production Units (PU). Product download and visualisation are hosted by 25 Dissemination Units (DU). All these products and associated services are gathered in a single catalogue hiding the intricate distributed organization of PUs and DUs. Besides applying INSPIRE directive and OGC recommendations, MyOcean overcomes technical choices and challenges. This presentation focuses on 3 specific issues met by MyOcean and relevant for many Spatial Data Infrastructures: user's transaction accounting, large volume download and stream line the catalogue maintenance. Transaction Accounting: Set up powerful means to get detailed knowledge of system usage in order to subsequently improve the products (ocean observations, analysis and forecast dataset) and services (view, download) offer. This subject drives the following ones: Central authentication management for the distributed web services implementations: add-on to THREDDS Data Server for WMS and NETCDF sub-setting service, specific FTP. Share user management with co-funding projects. In addition to MyOcean, alternate projects also need consolidated information about the use of the cofunded products. Provide a central facility for the user management. This central facility provides users' rights to geographically distributed services and gathers transaction accounting history from these distributed services. Propose a user-friendly web interface to download large volume of data (several GigaBytes) as robust as basic FTP but intuitive and file/directory independent. This should rely on a web service drafting the INSPIRE to-be specification and OGC recommendations for download taking into account that FTP server is not enough friendly (need to know filenames, directories) and Web-page not allowing downloading several files. Streamline the maintenance of the central catalogue. The major update for MyOcean v3 (April 2013) is the usage of Geonetwork for catalogue management. This improves the system at different levels : The editing interface is more user-friendly and the catalogue updates are managed in a workflow. This workflow allows higher flexibility for minor updates without giving up the high level qualification requirements for the catalogue content. The distributed web services (download, view) are automatically harvested from the THREDDS Data Server. Thus the manual editing on the catalogue is reduced, the associated typos are avoided and the quality of information is finally improved.

The Toxicity of Depleted Uranium

PubMed Central

Briner, Wayne

2010-01-01

Depleted uranium (DU) is an emerging environmental pollutant that is introduced into the environment primarily by military activity. While depleted uranium is less radioactive than natural uranium, it still retains all the chemical toxicity associated with the original element. In large doses the kidney is the target organ for the acute chemical toxicity of this metal, producing potentially lethal tubular necrosis. In contrast, chronic low dose exposure to depleted uranium may not produce a clear and defined set of symptoms. Chronic low-dose, or subacute, exposure to depleted uranium alters the appearance of milestones in developing organisms. Adult animals that were exposed to depleted uranium during development display persistent alterations in behavior, even after cessation of depleted uranium exposure. Adult animals exposed to depleted uranium demonstrate altered behaviors and a variety of alterations to brain chemistry. Despite its reduced level of radioactivity evidence continues to accumulate that depleted uranium, if ingested, may pose a radiologic hazard. The current state of knowledge concerning DU is discussed. PMID:20195447

Géochimie et cadre géodynamique du volcanisme néoprotérozoïque terminal (vendien) du Haut Atlas occidental, Maroc(Geochemical features and tectonic setting of late Neoproterozoic Vendian volcanism in the western High Atlas, Morocco)

NASA Astrophysics Data System (ADS)

Jouhari, A.; El-Archi, A.; Aarab, M.; El-Attari, A.; Ennih, N.; Laduron, D.

2001-05-01

Late Neoproterozoic Vendian volcanic and volcaniclastic rocks are widely distributed in the western High Atlas. They are located north of the Tizi n'Test Fault, separating the West African Craton from a northerly adjacent craton. These volcanic rocks overlie a semipelitic formation, which represents the equivalent of the Tidilline and Anzi Formations of the Anti-Atlas. The geochemical characteristics of these volcanic rocks suggest a calc-alkaline active margine environment associated with the post Pan-African tectonics. They differ from those of the Anti-Atlas by their lower content of K 2O. The later rock type was generated by a melting process of the crust subducted beneath the northern craton. A carbonate-shale unit, which contains examples of interstratified calc-alkaline dacite, overlies the volcanic succession, demonstrating that the volcanic activity continued sporadically until Early Cambrian times.

A generalized nonlocal vector calculus

NASA Astrophysics Data System (ADS)

Alali, Bacim; Liu, Kuo; Gunzburger, Max

2015-10-01

A nonlocal vector calculus was introduced in Du et al. (Math Model Meth Appl Sci 23:493-540, 2013) that has proved useful for the analysis of the peridynamics model of nonlocal mechanics and nonlocal diffusion models. A formulation is developed that provides a more general setting for the nonlocal vector calculus that is independent of particular nonlocal models. It is shown that general nonlocal calculus operators are integral operators with specific integral kernels. General nonlocal calculus properties are developed, including nonlocal integration by parts formula and Green's identities. The nonlocal vector calculus introduced in Du et al. (Math Model Meth Appl Sci 23:493-540, 2013) is shown to be recoverable from the general formulation as a special example. This special nonlocal vector calculus is used to reformulate the peridynamics equation of motion in terms of the nonlocal gradient operator and its adjoint. A new example of nonlocal vector calculus operators is introduced, which shows the potential use of the general formulation for general nonlocal models.

Hydrogeologic setting and the potentiometric surfaces of regional aquifers in the Hollandale Embayment, southeastern Minnesota, 1970-80

USGS Publications Warehouse

Delin, G.N.; Woodward, D.G.

1984-01-01

Potentiometric-surface maps for each aquifer indicate that movement of ground water is predominantly toward the major rivers. The St. Croix, Minnesota, and Mississippi Rivers constitute regional discharge boundaries for ground-water flow. A major ground-water divide in the St. Peter, Prairie du Chien-Jordan, Ironton-Galesville, and Mount Simon-Hinckley aquifers in the south-central part of the Hollandale embayment separates ground-water flow northward toward the Twin Cities area and southward toward Iowa. The St. Peter and Prairie du Chien-Jordan aquifers in the southeastern part of the embayment contain ground-water mounds as high as 90 ft above the regional potentiometric surface. The mounds occur as a result of increased recharge where the Decorah-Platteville-Glenwood confining bed has been removed by erosion and the aquifers subcrop beneath drift that is about 20 ft thick. This head distribution produces a locally complex pattern of flow in which ground water moves southwesterly toward Iowa instead of directly toward the Mississippi River.

Foundational Security Principles for Medical Application Platforms* (Extended Abstract)

PubMed Central

Vasserman, Eugene Y.; Hatcliff, John

2014-01-01

We describe a preliminary set of security requirements for safe and secure next-generation medical systems, consisting of dynamically composable units, tied together through a real-time safety-critical middleware. We note that this requirement set is not the same for individual (stand-alone) devices or for electronic health record systems, and we must take care to define system-level requirements rather than security goals for components. The requirements themselves build on each other such that it is difficult or impossible to eliminate any one of the requirements and still achieve high-level security goals. PMID:25599096

Amélioration des performances d'une implantation parallélovectorielle du gradient conjugué par extension du schéma de stockage matriciel

NASA Astrophysics Data System (ADS)

Magnin, H.; Coulomb, J. L.

1993-03-01

Electromagnetic field computation with the Finite Element (FE) method implies solving of large linear systems of equations. Performances and memory capacities of today computers allow to achieve three-dimensional FE discretizations of electromagnetic problems, but the number of unknowns grows high. So, to improve time to the numerical solution of the linear system(s) thus arising, the use of parallel and/or vector computers has to be envisaged. In this paper, the main constitutive steps of the Pre-conditioned Conjugate Gradient algorithm (PCG) are analysed. After a short recall of our previous work concerning their improvement by use of vector and parallel computations, we show some speedup limitations due to the sparse row-wise matrix storage scheme employed. Then, an extension of this matrix representation is proposed, leading to introduce redundant storage of non-zero coefficients. In spite of the “memory waste” thus implied, it is shown how this extension can be successfully employed to increase the speedup due to parallelism and vectorization on the whole algorithm, and in particular to derive a parallel preconditioner. La résolution par la méthode des éléments finis des équations de l'électromagnétisme conduit à résoudre de grands systèmes d'équations linéaires. Les capacités mémoire et les performances actuelles des systèmes informatiques permettent de traiter les problèmes électromagnétiques par discrétisation tridimensionnelle, mais alors le nombre d'inconnues devient très élevé. Ainsi, la résolution en un temps raisonnable des équations linéaires associées à de telles discrétisations conduit à envisager l'emploi d'ordinateurs à architecture parallèle. Dans cet article, les différentes étapes constitutives de l'algorithme du gradient conjugué préconditionné (GCP) sont analysées. Après un court rappel de nos travaux antérieurs concemant leur amélioration par utilisation de traitements parallèles et vectoriels, nous montrons les limitations du gain de temps dues au mode de stockage matriciel utilisé : la représentation creuse dite “Morse”. Nous proposons alors une extension de ce mode de stockage, conduisant à l'introduction de redondance au niveau du rangement des termes matriciels en mémoire. Malgré le “gaspillage” mémoire ainsi occasionné, il apparait que cette extension peut être mise à profit pour augmenter sensiblement les gains par parallélisation et vectorisation de l'ensemble de l'algorithme du gradient conjugué, et notamment pour la réalisation d'un pré-conditionnement parallèle.

Geochemical and stable isotopic evolution of the Guarani Aquifer System in the state of São Paulo, Brazil

NASA Astrophysics Data System (ADS)

Sracek, Ondra; Hirata, Ricardo

2002-09-01

The purpose of this report is to explain geochemical and stable isotopes trends in the Brazilian unit of the Guarani Aquifer System (Botucatu and Piramboia aquifers) in São Paulo State, Brazil. Trends of dissolved species concentrations and geochemical modeling indicated a significant role of cation exchange and dissolution of carbonates in downgradient evolution of groundwater chemistry. Loss of calcium by the exchange for sodium drives dissolution of carbonates and results in Na-HCO3 type of groundwater. The cation-exchange front moves downgradient at probably much slower rate compared to the velocity of groundwater flow and at present is located near to the cities of Sertãozinho and Águas de Santa Barbara (wells PZ-34 and PZ-148, respectively) in a shallow confined area, 50-70 km from the recharge zone. Part of the sodium probably enters the Guarani Aquifer System. together with chloride and sulfate from the underlying Piramboia Formation by diffusion related to the dissolution of evaporates like halite and gypsum. High concentrations of fluorine (up to 13.3 mg/L) can be explained by dissolution of mineral fluoride also driven by cation exchange. However, it is unclear if the dissolution takes place directly in the Guarani Aquifer System or in the overlying basaltic Serra Geral Formation. There is depletion in δ2H and δ18O values in groundwater downgradient. Values of δ13C(DIC) are enriched downgradient, indicating dissolution of calcite under closed system conditions. Values of δ13C(DIC) in deep geothermal wells are very high (>-6.0‰) and probably indicate isotopic exchange with carbonates with δ13C about -3.0‰. Future work should be based on evaluation of vertical fluxes and potential for penetration of contamination to the Guarani Aquifer System. Résumé. Cet article a pour objet d'expliquer l'évolution de la géochimie et des isotopes stables dans l'unité brésilienne du système aquifère du Guarani (aquifères de Botucatu et Piramboia), dans l'État de Sao Paulo (Brésil). L'évolution des concentrations des espèces dissoutes et la modélisation géochimique ont fait apparaître le rôle notable des échanges de cations et de la dissolution des carbonates de l'amont vers l'aval des nappes. La perte de calcium par échange de cation avec le sodium pilote la dissolution des carbonates et donne naissance à des eaux souterraines à faciès Na-HCO3. Le front d'échange de cation se déplace vers l'aval probablement plus lentement que la vitesse d'écoulement de l'eau souterraine et est actuellement situé à proximité des villes de Sertaozinho et de Aguas de Santa Barbara (respectivement puits PZ-34 et PZ-148), dans une zone captive proche de la surface, à 50-70 km de la zone de recharge. Une partie du sodium provient probablement du système aquifère du Guarani, associée aux chlorures et aux sulfates de la formation Piramboia sous-jacente, par diffusion liée à la dissolution d'évaporites comme la halite et le gypse. De fortes concentrations en fluorures (jusqu'à 13,3 mg/L) peuvent être expliquées par la dissolution d'un minéral fluoré également pilotée par l'échange de cations. Cependant, on ne sait pas bien si la dissolution intervient directement dans le système aquifère du Guarani ou dans la formation basaltique sus-jacente de Serra Geral. Les valeurs de δ2H et δ18O décroissent vers l'aval de la nappe. Les valeurs de δ13C du carbone minéral dissous sont enrichies vers l'aval, indiquant qu'il se produit une dissolution de calcite en système fermé. Les valeurs de δ13C du carbone minéral dissous dans les puits géothermaux profonds sont très élevées (supérieures à -6,0‰) et rendent probablement compte d'échanges isotopiques avec des carbonates possédant un δ13C d'environ -3,0‰. De prochaines études devront s'attacher à évaluer les flux verticaux et le potentiel de pénétration de contamination du système aquifère du Guarani. Resumen. El propósito de este informe es explicar las tendencias geoquímicas y de los isótopos estables en la unidad brasileña del Sistema Acuífero Guaraní (acuíferos de Botucatu y Piramboya), en el Estado de Sao Paulo. Las concentraciones de especies disueltas y los resultados de modelaciones geoquímicas indican que el intercambio catiónico y la disolución de carbonatos desempeñan un papel importante en la evolución aguas abajo del acuífero. La disminución de calcio por el intercambio con sodio origina la disolución de carbonatos, dando lugar a aguas subterráneas de tipo bicarbonatado sódico. El frente de intercambio catiónico se desplaza a una velocidad probablemente mucho más lenta que la del flujo de agua; actualmente, se halla cerca de las ciudades de Sertaozinho y Aguas de Santa Bárbara (pozos PZ-34 y PZ-148, respectivamente), en una zona confinada somera que dista entre 50 y 70 km del área de recarga. Parte del sodio entra probablemente en el Sistema Acuífero Guaraní junto con el cloruro y el sulfato procedentes de la Formación Piramboia inferior, debido a la difusión relacionada con la disolución de evaporitas como la halita y los yesos. Se puede explicar las elevadas concentraciones de flúor (hasta 13,3 mg/L) por la disolución de fluoruro mineral, que sucede también por intercambio catiónico. Sin embargo, no está claro si la disolución ocurre directamente en el Sistema Acuífero Guaraní o en la Formación basáltica superior de Serra Geral. Hay una reducción de δ2H y de δ18O a favor del gradiente hidráulico. Hay un enriquecimiento en δ13C inorgánico aguas abajo, lo que indica que la calcita se disuelve en condiciones de sistema cerrado. Los valores de δ13C inorgánico en pozos geotérmicos profundos son muy altos (mayores que -6,0‰), y probablemente apuntan a un intercambio isotópico con carbonatos de δ13C que tiene un valor del orden del -3,0‰. Las líneas de investigación deberían centrarse en evaluar los flujos verticales y el potencial de penetración de contaminantes en el Sistema Acuífero Guaraní.

NATO Human Resources (Manpower) Management (Gestion des ressources humaines (effectifs) de l’OTAN)

DTIC Science & Technology

2012-02-01

performances , la gestion des récompenses et du salaire, et la motivation du personnel. En conséquence, il faut que la gestion des ressources humaines...importance au fil du temps. Les ressources humaines, chargées à l’origine de l’embauche, du licenciement, de la paie et de la gestion des ...les effets des systèmes d’évaluation des performances ;

The Seamless Maritime Concept

DTIC Science & Technology

2005-03-01

example demonstrating both the power and profitability of this strategy is the Cirque du Soleil . The Cirque du Soleil is a result of the effort to...ballet, and recognizing the value of the strengths of each and leveraging those strengths into a new market. The Cirque du Soleil is a dramatic...reduce the production costs and over head associated with running a circus, improve the entertainment value, and create a new market. Cirque du

Molecular characterization of allelic variants of (GATA)n microsatellite loci in parthenogenetic lizards Darevskia unisexualis (Lacertidae).

PubMed

Korchagin, V I; Badaeva, T N; Tokarskaya, O N; Martirosyan, I A; Darevsky, I S; Ryskov, A P

2007-05-01

Populations of parthenogenetic lizards of the genus Darevskia consist of genetically identical animals, and represent a unique model for studying the molecular mechanisms underlying the variability and evolution of hypervariable DNA repeats. As unisexual lineages, parthenogenetic lizards are characterized by some level of genetic diversity at microsatellite loci. We cloned and sequenced a number of (GATA)n microsatellite loci of Darevskia unisexualis. PCR products from these loci were also sequenced and the degree of intraspecific polymorphism was assessed. Among the five (GATA)n loci analysed, two (Du215 and Du281) were polymorphic. Cross-species analysis of Du215 and Du281 indicate that the priming sites at the D. unisexualis loci are conserved in the bisexual parental species, D. raddei and D. valentini. Sequencing the PCR products amplified from Du215 and Du281 and from monomorphic Du323 showed that allelic differences at the polymorphic loci are caused by microsatellite mutations and by point mutations in the flanking regions. The haplotypes identified among the allelic variants of Du281 and among its orthologues in the parental species provide new evidence of the cross-species origin of D. unisexualis. To our knowledge, these data are the first to characterize the nucleotide sequences of allelic variants at microsatellite loci within parthenogenetic vertebrate animals.

Portage vaginal du streptocoque du groupe B chez la femme enceinte au niveau de la région de Marrakech

PubMed Central

Bassir, Ahlam; Dhibou, Hanane; Farah, Majdi; Mohamed, Lharmis; Amal, Addebous; Nabila, Souraa; Abderahim, Aboulfalah; Asmouki, Hamid; Soummani, Abderraouf

2016-01-01

Introduction Le streptocoque du groupe B est le principal agent impliqué dans les infections materno-fœtales, les septicémies et les méningites du nouveau-né à terme. L'objectif est de déterminer le taux de portage maternel du streptocoque du groupe B (SGB) à terme. Méthodes Un prélèvement vaginal a été réalisé de manière prospective chez 275 parturientes lors de l'entrée en salle d'accouchement sur une période de 06 mois. Résultats Le taux de portage était de 20,2%. Le portage était variable en fonction de l’âge gestationnel, il constitue 57.5% entre 37 et 38 semaines d'aménorrhée. Aucun des facteurs de risque n'a était statistiquement prédictif du portage maternel du SGB. Conclusion Le dépistage doit être réalisé à partir de 37 semaines d'aménorrhée, et comme le portage est intermittent, un prélèvement négatif ne garantirait pas que le portage soit négatif à l'accouchement. PMID:27222693

Strapdown system redundancy management flight demonstration. [vertical takeoff and landing aircraft

NASA Technical Reports Server (NTRS)

1978-01-01

The suitability of strapdown inertial systems in providing highly reliable short-term navigation for vertical take-off and landing (VTOL) aircraft operating in an intra-urban setting under all-weather conditions was assessed. A preliminary design configuration of a skewed sensor inertial reference system employing a redundancy management concept to achieve fail-operational, fail-operational performance, was developed.

Guideline on Scenario Development for (Distributed) Simulation Environments (Guide en vue du developpement de scenario dans le cadre de simulation distribuee)

DTIC Science & Technology

2015-01-01

des lacunes de M&S du MORS du NMSG a déterminé que le manque d’interopérabilité de la simulation constituait la lacune prioritaire à combler en...matière de capacité, une équipe exploratoire (ET-027) a été constituée au sein du NMSG pour étudier l’interopérabilité de la simulation. L’ET-027 a...élevés (autrement dit, aux niveaux pratique, dynamique et conceptuel) de même que l’automatisation relative du développement, de

A generalized approach to computer synthesis of digital holograms

NASA Technical Reports Server (NTRS)

Hopper, W. A.

1973-01-01

Hologram is constructed by taking number of digitized sample points and blending them together to form ''continuous'' picture. New system selects better set of sample points resulting in improved hologram from same amount of information.

Western Dilemma

ScienceCinema

None

2017-12-09

L'association du personnel présente Anthony Sampson, écrivain connu dans le monde entier par ses nombreux ouvrages et publications (International Harold Tribune, Observer, News Week). Il nous parle du commerce des armes et du Moyen Orient.

Kyste hydatique mammaire primitive

PubMed Central

Boufettal, Houssine; Samouh, Naïma

2015-01-01

La localisation mammaire du kyste hydatique est exceptionnelle. De ce fait, le diagnostic est difficile avant l'examen anatomopathologique. Nous rapportons une observation d'un cas de kyste hydatique du sein chez une femme de 32 ans, qui consultait pour un nodule du sein, dont l'imagerie montrait une lésion en rétro-aréolaire du sein gauche, homogène, ovalaire et de contours réguliers. L'examen anatomopathologique objectivait un kyste hydatique à localisation mammaire. Les suites opératoires étaient simples. L'hydatidose est une maladie ubiquitaire, pouvant atteindre tous les organes. Le diagnostic peut être évoqué devant une masse kystique du sein avec des aspects très évocateurs à l'imagerie. La confirmation du diagnostic n'est confirmée qu'après une cytoponction ou une chirurgie d'exérèse qui réalise le traitement de cette pathologique. La négativité du bilan d'extension hydatique permet de retenir une localisation primitive de l’échinococcose. PMID:26185575

Etude de l'affaiblissement du comportement mecanique du pergelisol du au rechauffement climatique

NASA Astrophysics Data System (ADS)

Buteau, Sylvie

Le rechauffement climatique predit pour les prochaines decennies, aura des impacts majeurs sur le pergelisol qui sont tres peu documentes pour l'instant. La presente etude a pour but d'evaluer ces impacts sur les proprietes mecaniques du pergelisol et sa stabilite a long terme. Une nouvelle technique d'essai de penetration au cone a taux de deformation controle, a ete developpee pour caracteriser en place le pergelisol. Ces essais geotechniques et la mesure de differentes proprietes physiques ont ete effectues sur une butte de pergelisol au cours du printemps 2000. Le developpement et l'utilisation d'un modele geothermique 1D tenant compte de la thermodependance du comportement mecanique ont permis d'evaluer que les etendues de pergelisol chaud deviendraient instables a la suite d'un rechauffement de l'ordre de 5°C sur cent ans. En effet, la resistance mecanique du pergelisol diminuera alors rapidement jusqu'a 11,6 MPa, ce qui correspond a une perte relative de 98% de la resistance par rapport a un scenario sans rechauffement.

Conception, fabrication et validation d'une presse a injection basse pression pour le procede des poudres metalliques =

NASA Astrophysics Data System (ADS)

Lamarre, Simon G.

Le moulage par injection a basse pression de poudre metallique est une technique de mise en forme de pieces de formes complexes. La poudre metallique est melangee avec des polymeres basse viscosite (ex. : cire) pour former un melange homogene a une temperature superieure a la temperature de fusion des polymeres. Pour faciliter l'injection dans la cavite du moule, la composition des melanges est ajustee pour diminuer la viscosite. D'une part, les melanges peu visqueux possedent une bonne moulabilite. D'autre part, le phenomene de la segregation se manifeste rapidement avec les melanges peu visqueux. Les machines commerciales sont munies d'un canal d'injection et d'une valve qui relient le reservoir de melange et la cavite du moule. Le melange reste stationnaire dans ces composantes entre deux sequences d'injection, ce qui le rend propice a la segregation. Plusieurs brevets tentent de resoudre ce probleme en utilisant des pompes et des canaux de recirculation. Ces composantes sont difficiles a nettoyer en raison de leur complexite. Une machine a injection basse pression a ete concue et fabriquee pour l'etude de l'aptitude au moulage des melanges de tres faible viscosite (ex. : 0.1 Pa˙s), qui tient compte du phenomene de segregation et des contraintes de nettoyage. Un piston d'injection puise le volume desire d'un reservoir. Ensuite, un mouvement lateral cisaille le melange a l'intersection entre le reservoir et le cylindre et bouche l'orifice de sortie du reservoir. Le cylindre est degage et peut recevoir le moule. A la suite de l'injection, le piston retourne a la position du reservoir et entre dans son orifice de sortie. Le melange residuel est retourne dans le reservoir, melange et desaere a nouveau. L'appareil a ete valide par des essais d'injectabilite avec un melange de poudre d'acier inoxydable et de liants a basse viscosite. Des essais d'injection ont montre que le melange contenant l'acide stearique a parcouru la plus grande distance dans le moule de forme spirale, suivi du melange contenant l'acide stearique et l'ethylene vinyle acetate et finalement du melange contenant seulement la cire de paraffine. Des essais de rheologie ont correle ces resultats pour une viscosite associee a un faible taux de cisaillement. Un essai de segregation a montre qu'un temps d'attente de moins d'une minute devait etre respecte avant de mesurer une segregation importante. De plus, le fonctionnement du systeme de vacuum a ete valide par des analyses radiographiques. Un temps de melange sous vacuum de 30 min est suffisant pour eliminer completement la presence de bulles d'air dans la piece injectee.

Manoomin: place-based research with Native American students on wild rice lakes on the Fond du Lac Band of Lake Superior Chippewa Reservation, northern Minnesota

NASA Astrophysics Data System (ADS)

Ito, E.; Myrbo, A.; Dalbotten, D. M.; Pellerin, H.; Greensky, L.; Howes, T.; Wold, A.; McEathron, M. A.; Shanker, V.

2010-12-01

The manoomin project is a collaboration between Fond du Lac Tribal and Community College (Cloquet, MN), the Reservation’s Resource Management Division, and the University of Minnesota funded by the NSF GEO-OEDG Program. It builds on a successful seven-year history of collaboration between these parties, including regular science camps (gidaakiimanaanimigawig, Our Earth Lodge) for students of a wide range of ages. We are working as a team with Native students to study the history of wild rice (manoomin; Zizania palustris), a culturally important resource, growing on Reservation lakes. The joint project takes two main approaches: study of sediment core samples collected from Reservation lakes; and the collection of traditional knowledge about wild rice from the Elders. Science campers collect lake cores during winter with the assistance of the U of MN’s LacCore (National Lacustrine Core Facility) and Resource Management and visit LacCore to log, split and describe cores soon thereafter. Academic mentors with a range of specialties (phytoliths, pollen, plant macrofossils, sedimentology, geochemistry, magnetics) spend 1-2 weeks during the summer with small groups of college-age (>18, many nontraditional) student interns working on a particular paleoenvironmental proxy from the sediment cores. Younger students (middle and high school) also work in small teams in half day units with the same mentors. All campers become comfortable in an academic setting, gain experience working in research labs learning and practicing techniques, and jointly interpret collective results. The continuation of the project over five years (2009-2014) will allow these students to develop relationships with scientists and to receive mentoring beyond the laboratory as they make transitions into 2- and 4-year colleges and into graduate school. Their research provides historical and environmental information that is relevant to their own land that will be used by Resource Management which is charged to protect the wild rice and to improve its growth to better understand these ecosystems in the context of current global and local change. A substantial evaluation component charts progress and provides feedback to project participants and the larger community.

Séroprévalence et facteurs associés à l’acceptation du Conseil et Dépistage Volontaire du VIH chez l’enfant à Lubumbashi, République Démocratique du Congo

PubMed Central

Ngwej, Dieudonné Tshikwej; Mukuku, Olivier; Malonga, Françoise Kaj; Luboya, Oscar Numbi; Kakoma, Jean-Baptiste Sakatolo; Wembonyama, Stanis Okitotsho

2017-01-01

Résumé Introduction Malgré le dépistage du VIH proposé lors de la naissance ou au cours des consultations préscolaires, la proportion des enfants qui croissent ou décèdent sous statut sérologique au VIH inconnu est importante en République Démocratique du Congo (RDC). L’objectif de cette étude était de déterminer la séroprévalence au cours d’un dépistage volontaire et d’identifier les facteurs associés à l’acceptation du conseil et dépistage du VIH (CDV) en dehors de la maladie ou de toute exposition au VIH dans une population pédiatrique à Lubumbashi, RDC. Méthodes Il s’agissait d’une étude prospective transversale à visée analytique menée du 1er août 2006 au 31 septembre 2007. Elle avait été réalisée dans 4 centres communautaires de CDV répartis dans 4 zones de santé de la ville de Lubumbashi en RDC (Lubumbashi, Ruashi, Kampemba et de Kenya). L’étude avait consisté à faire le dépistage volontaire du VIH chez les enfants de moins de 15 ans. Les caractéristiques sociodémographiques et les paramètres relatifs au conseil et dépistage volontaire ont été étudiés. Les analyses statistiques descriptives usuelles et une régression logistique ont été réalisées. Résultats Sur 463 enfants dépistés du VIH, 41 (8,9%; IC 95%: 6,5%-11,9%) ont été testés positifs. L’acceptation du conseil et dépistage volontaire du VIH en dehors de la maladie ou de l’exposition au VIH était significativement plus élevée lorsque l’enfant était âgé de plus de 2 ans (Odds ratio ajusté (ORa) = 3,6 [IC 95%: 1,1-12,2]), lorsque le statut sérologique du VIH des parents était négatif ou inconnu (ORa = 27,4 [IC 95%: 9,4-80,0]), lorsque l’un ou l’autre ou les deux parents biologiques étaient en vie (ORa = 24,9 [IC 95%: 2,4-250,8]) et lorsque la connaissance du lieu de dépistage était fait par des moyens autres que le professionnel de santé (ORa = 2,9 [IC 95%: 1,0-7,9]). Conclusion Notre étude montre une forte prévalence du VIH chez les enfants justifiant la nécessité de réaliser le CDV qui est significativement accepté par leurs parents et tuteurs dans la ville de Lubumbashi. PMID:29255552

[It is time to take cancer prevention seriously].

PubMed

Hill, Catherine

2015-06-01

Preventing cancer by reducing exposure to carcinogens is the only way to reduce the frequency of cancers in the population. We discuss the current situation of cancer prevention in France in the order of importance as measured by the risk, demonstrating the recent reversal of the national anti-tobacco policy, the large benefit that could be expected from a reduction in alcohol consumption, the low coverage of the population for papillomavirus and hepatitis B virus vaccinations. Copyright © 2015 Société Françise du Cancer. Publié par Elsevier Masson SAS. Tous droits réservés. Published by Elsevier Masson SAS. All rights reserved.

Chemours Pompton Lakes Works Site, Pompton Lakes, NJ

EPA Pesticide Factsheets

E.I. DuPont De Nemours & Company is located at 2000 Cannonball Road, Pompton Lakes, New Jersey. The DuPont Pompton Lakes Works site (DuPont) occupies approximately 570 acres of land in Pompton Lakes and Wanaque.

La reconstruction du sourcil par greffon composite du cuir chevelu: une astuce pour faciliter la technique

PubMed Central

El Omari, Mounia; El Mazouz, Samir; Gharib, Noureddine; EL Abbassi, Abdallah

2015-01-01

Les sourcils jouent un rôle important dans l’équilibre esthétique du visage. Leur reconstruction ou ophriopoïése, après séquelle de brûlure fait partie intégrante du programme de réhabilitation de la face brûlée. Plusieurs techniques ont été décrites. Nous insistons ici sur l'intérêt d'une technique simple, à la portée de tous les chirurgiens, et dont la méthode et les résultats peuvent être améliorés par un dessin bien planifié des zones donneuse et receveuse: la greffe composite prélevée au niveau du cuir chevelu dessinée à l'aide d'un calque du sourcil controlatéral. PMID:26401195

Performability modeling with continuous accomplishment sets

NASA Technical Reports Server (NTRS)

Meyer, J. F.

1979-01-01

A general modeling framework that permits the definition, formulation, and evaluation of performability is described. It is shown that performability relates directly to system effectiveness, and is a proper generalization of both performance and reliability. A hierarchical modeling scheme is used to formulate the capability function used to evaluate performability. The case in which performance variables take values in a continuous accomplishment set is treated explicitly.

Fluctuations Magnetiques des Gaz D'electrons Bidimensionnels: Application AU Compose Supraconducteur LANTHANE(2-X) Strontium(x) Cuivre OXYGENE(4)

NASA Astrophysics Data System (ADS)

Benard, Pierre

Nous presentons une etude des fluctuations magnetiques de la phase normale de l'oxyde de cuivre supraconducteur La_{2-x}Sr _{x}CuO_4 . Le compose est modelise par le Hamiltonien de Hubbard bidimensionnel avec un terme de saut vers les deuxiemes voisins (modele tt'U). Le modele est etudie en utilisant l'approximation de la GRPA (Generalized Random Phase Approximation) et en incluant les effets de la renormalisation de l'interaction de Hubbard par les diagrammes de Brueckner-Kanamori. Dans l'approche presentee dans ce travail, les maximums du facteur de structure magnetique observes par les experiences de diffusion de neutrons sont associes aux anomalies 2k _{F} de reseau du facteur de structure des gaz d'electrons bidimensionnels sans interaction. Ces anomalies proviennent de la diffusion entre particules situees a des points de la surface de Fermi ou les vitesses de Fermi sont tangentes, et conduisent a des divergences dont la nature depend de la geometrie de la surface de Fermi au voisinage de ces points. Ces resultats sont ensuite appliques au modele tt'U, dont le modele de Hubbard usuel tU est un cas particulier. Dans la majorite des cas, les interactions ne determinent pas la position des maximums du facteur de structure. Le role de l'interaction est d'augmenter l'intensite des structures du facteur de structure magnetique associees a l'instabilite magnetique du systeme. Ces structures sont souvent deja presentes dans la partie imaginaire de la susceptibilite sans interaction. Le rapport d'intensite entre les maximums absolus et les autres structures du facteur de structure magnetique permet de determiner le rapport U_ {rn}/U_{c} qui mesure la proximite d'une instabilite magnetique. Le diagramme de phase est ensuite etudie afin de delimiter la plage de validite de l'approximation. Apres avoir discute des modes collectifs et de l'effet d'une partie imaginaire non-nulle de la self-energie, l'origine de l'echelle d'energie des fluctuations magnetiques est examinee. Il est ensuite demontre que le modele a trois bandes predit les memes resultats pour la position des structures du facteur de structure magnetique que le modele a une bande, dans la limite ou l'hybridation des orbitales des atomes d'oxygene des plans Cu-O_2 et l'amplitude de sauts vers les seconds voisins sont nulles. Il est de plus constate que l'effet de l'hybridation des orbitales des atomes d'oxygene est bien modelise par le terme de saut vers les seconds voisins. Meme si ils decrivent correctement le comportement qualitatif des maximums du facteur de structure magnetique, les modeles a trois bandes et a une bande ne permettent pas d'obtenir une position de ces structures conforme avec les mesures experimentales, si on suppose que la bande est rigide, c'est-a-dire que les parametres du Hamiltonien sont independants de la concentration de strontium. Ceci peut etre cause par la dependance des parametres du Hamiltonien sur la concentration de strontium. Finalement, les resultats sont compares avec les experiences de diffusion de neutrons et les autres theories, en particulier celles de Littlewood et al. (1993) et de Q. Si et al. (1993). La comparaison avec les resultats experimentaux pour le compose de lanthane suggere que le liquide de Fermi possede une surface de Fermi disjointe, et qu'il est situe pres d'une instabilite magnetique incommensurable.

Automated Vectorization of Decision-Based Algorithms

NASA Technical Reports Server (NTRS)

James, Mark

2006-01-01

Virtually all existing vectorization algorithms are designed to only analyze the numeric properties of an algorithm and distribute those elements across multiple processors. This advances the state of the practice because it is the only known system, at the time of this reporting, that takes high-level statements and analyzes them for their decision properties and converts them to a form that allows them to automatically be executed in parallel. The software takes a high-level source program that describes a complex decision- based condition and rewrites it as a disjunctive set of component Boolean relations that can then be executed in parallel. This is important because parallel architectures are becoming more commonplace in conventional systems and they have always been present in NASA flight systems. This technology allows one to take existing condition-based code and automatically vectorize it so it naturally decomposes across parallel architectures.

40 CFR 52.741 - Control strategy: Ozone control measures for Cook, DuPage, Kane, Lake, McHenry and Will Counties.

Code of Federal Regulations, 2011 CFR

2011-07-01

... abatement or recovery device. Capture system means all equipment (including, but not limited to, hoods... translucent solid protective film. Closed vent system means a system that is not open to the atmosphere and is... evaporation of water. Condensate means volatile organic liquid separated from its associated gases, which...

In Vivo Detection of Hyperoxia-Induced Pulmonary Endothelial Cell Death Using 99mTc-Duramycin

PubMed Central

Audi, Said H.; Jacobs, Elizabeth R.; Zhao, Ming; Roerig, David L.; Haworth, Steven T.; Clough, Anne V.

2014-01-01

Introduction: 99mTc-duramycin, DU, is a SPECT biomarker of tissue injury identifying cell death. The objective of this study is to investigate the potential of DU imaging to quantify capillary endothelial cell death in rat lung injury resulting from hyperoxia exposure as a model of acute lung injury. Methods: Rats were exposed to room air (normoxic) or >98% O2 for 48 or 60 hours. DU was injected i.v. in anesthetized rats, scintigraphy images were acquired at steady-state, and lung DU uptake was quantified from the images. Post-mortem, the lungs were removed for histological studies. Sequential lung sections were immunostained for caspase activation and endothelial and epithelial cells. Results: Lung DU uptake increased significantly (p < 0.001) by 39% and 146% in 48-hr and 60-hr exposed rats, respectively, compared to normoxic rats. There was strong correlation (r2 = 0.82, p = 0.005) between lung DU uptake and the number of cleaved caspase 3 (CC3) positive cells, and endothelial cells accounted for more than 50% of CC3 positive cells in the hyperoxic lungs. Histology revealed preserved lung morphology through 48 hours. By 60 hours there was evidence of edema, and modest neutrophilic infiltrate. Conclusions: Rat lung DU uptake in vivo increased after just 48 hours of >98% O2 exposure, prior to the onset of any substantial evidence of lung injury. These results suggest that apoptotic endothelial cells are the primary contributors to the enhanced DU lung uptake, and support the utility of DU imaging for detecting early endothelial cell death in vivo. PMID:25218023

Teratogenicity of depleted uranium aerosols: A review from an epidemiological perspective

PubMed Central

Hindin, Rita; Brugge, Doug; Panikkar, Bindu

2005-01-01

Background Depleted uranium is being used increasingly often as a component of munitions in military conflicts. Military personnel, civilians and the DU munitions producers are being exposed to the DU aerosols that are generated. Methods We reviewed toxicological data on both natural and depleted uranium. We included peer reviewed studies and gray literature on birth malformations due to natural and depleted uranium. Our approach was to assess the "weight of evidence" with respect to teratogenicity of depleted uranium. Results Animal studies firmly support the possibility that DU is a teratogen. While the detailed pathways by which environmental DU can be internalized and reach reproductive cells are not yet fully elucidated, again, the evidence supports plausibility. To date, human epidemiological data include case examples, disease registry records, a case-control study and prospective longitudinal studies. Discussion The two most significant challenges to establishing a causal pathway between (human) parental DU exposure and the birth of offspring with defects are: i) distinguishing the role of DU from that of exposure to other potential teratogens; ii) documentation on the individual level of extent of parental DU exposure. Studies that use biomarkers, none yet reported, can help address the latter challenge. Thoughtful triangulation of the results of multiple studies (epidemiological and other) of DU teratogenicity contributes to disentangling the roles of various potentially teratogenic parental exposures. This paper is just such an endeavor. Conclusion In aggregate the human epidemiological evidence is consistent with increased risk of birth defects in offspring of persons exposed to DU. PMID:16124873

Long-term fate of depleted uranium at Aberdeen and Yuma Proving Grounds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ebinger, M.H.; Essington, E.H.; Gladney, E.S.

1990-06-01

The environmental fate of fragments of depleted uranium (DU) penetrators in soils and waters at Aberdeen Proving Ground (APG) and Yuma Proving Ground (YPG) is a concern to the Testing and Evaluation Command (TECOM) of the US Army. This report presents the information from preliminary soil and water samples that were collected from the humid woodlands of APG and the arid Sonoran Desert of YPG. Soil samples collected beneath a penetrator fragment of the firing range at APG showed approximately 12% DU by weight in the surface horizon and DU significantly above background to a depth of about 20 cm.more » Samples of surface water at APG showed U only at background levels, and bottom sediments showed background U levels but with isotopic ratios of DU instead of natural U. Soil samples beneath a penetrator fragment at YPG showed about 0.5% by weight U in the surface horizon, but only background concentrations and isotopic ratios of U between 8 and 20 cm depth. Results from this preliminary study indicate that DU at APG was redistributed primarily be dissolution and transport with water and possibly by migration of DU colloids or DU attached to small particles. Redistribution at YPG, however, was mainly due to erosion of DU fragments from the impact area and redeposition in washes that drain the area. Proposed work for FY90-FY92 includes additional field sampling, laboratory column studies, and the development of a computer model of DU redistribution at both sites. 39 refs., 11 figs., 5 tabs.« less

Selection and life history traits of tebufenozide-resistant sugarcane borer (Lepidoptera: Crambidae).

PubMed

Akbar, W; Ottea, J A; Beuzelin, J M; Reagan, T E; Huang, F

2008-12-01

Varying susceptibility to tebufenozide was recorded in the sugarcane borer, Diatraea saccharalis (F.) (Lepidoptera: Crambidae), collected from Louisiana sugarcane locations with different selection pressures. Results from diet incorporation bioassays with tebufenozide indicated significant increases in LC50 (3.78-fold) and LC90 (7-fold) values for a colony from Duson (DU), an area with higher selection pressure, compared with a colony from Alexandria (ALEX), an area with no selection pressure. Differences were not detected in LC50 values among colonies from areas where use of tebufenozide was discontinued or rotated with other chemistries. Selections with tebufenozide of DU larvae over 12 generations resulted in a highly resistant colony (DU-R) with 27.1- and 83.3-fold increases in LC50 and LC90 values, respectively. Comparison of pupal weight, days to pupation, and emergence after exposure to an equitoxic (LC20) concentration of tebufenozide revealed a decrease in pupal weight (34 and 33% for males and females, respectively), and an increase in days to pupation (47 and 40% for males and females, respectively), and emergence (43 and 33% for males and females, respectively) for the DU-R colony compared with the parent DU colony. Fecundity of DU-R females decreased to 72 eggs per female compared with 180 (DU) and 261 (ALEX). Egg viability of the ALEX and DU colonies was 61 and 56%, respectively, whereas only 27% of eggs laid by females from the DU-R colony hatched. These results are discussed in terms of their practical implications for control of D. saccharalis in Louisiana sugarcane.

Mise à jour sur le nouveau vaccin 9-valent pour la prévention du virus du papillome humain

PubMed Central

Yang, David Yi; Bracken, Keyna

2016-01-01

Résumé Objectif Informer les médecins de famille quant à l’efficacité, à l’innocuité, aux effets sur la santé publique et à la rentabilité du vaccin 9-valent contre le virus du papillome humain (VPH). Qualité des données Des articles pertinents publiés dans PubMed jusqu’en mai 2015 ont été examinés et analysés. La plupart des données citées sont de niveau I (essais randomisés et contrôlés et méta-analyses) ou de niveau II (études transversales, cas-témoins et épidémiologiques). Des rapports et recommandations du gouvernement sont aussi cités en référence. Message principal Le vaccin 9-valent contre le VPH, qui offre une protection contre les types 6, 11, 16, 18, 31, 33, 45, 52 et 58 du VPH, est sûr et efficace et réduira encore plus l’incidence des infections à VPH, de même que les cas de cancer lié au VPH. Il peut également protéger indirectement les personnes non immunisées par l’entremise du phénomène d’immunité collective. Un programme d’immunisation efficace peut prévenir la plupart des cancers du col de l’utérus. Les analyses montrent que la rentabilité du vaccin 9-valent chez les femmes est comparable à celle du vaccin quadrivalent original contre le VPH (qui protège contre les types 6, 11, 16 et 18 du VPH) en usage à l’heure actuelle. Toutefois, il faut investiguer plus en profondeur l’utilité d’immuniser les garçons avec le vaccin 9-valent contre le VPH. Conclusion en plus d’être sûr, le vaccin 9-valent protège mieux contre le VPH que le vaccin quadrivalent. Une analyse coûtefficacité en favorise l’emploi, du moins chez les adolescentes. Ainsi, les médecins devraient recommander le vaccin 9-valent à leurs patients plutôt que le vaccin quadrivalent contre le VPH.

Pseudarthrose de l'extrémité inférieure du fémur traitée par mégaprothèse: à propos d'un cas et revue de la littérature

PubMed Central

Elidrissi, Mohammed; Hammou, Nassereddine; Shimi, Mohammed; Elibrahimi, Abdelhalim; Elmrini, Abdelmajid

2013-01-01

Les pseudarthroses de l'extrémité distale du fémur sont relativement rares du fait de la qualité de la vascularisation de cette région. La prise en charge d'une telle complication pose un certain nombre de difficultés. Le traitement chirurgical fait appel à plusieurs techniques conservatrices, le traitement par prothèse peut s'avérer utile quand la perte de substance est importante chez le sujet âgé. L'objectif de ce travail est de discuter l'intérêt de la mégaprothèse du genou dans le traitement de la pseudarthrose de l'extrémité distale du fémur, à travers l’étude de l'observation d'une patiente et revue de la littérature. Il s'agit d'une patiente âgée de 62 ans qui présente une pseudarthrose de l'extrémité distale du fémur gauche. Sur le plan clinique la patiente présente des douleurs du genou gauche, avec gène fonctionnelle importante. Le score de l'IKS préopératoire était de 60. Elle a bénéficié d'un remplacement prothétique par une mégaprothèse du genou. En postopératoire la flexion du genou était à 90°, le score de l'IKS était de 130. A travers l’étude de cette observation, et la revue de la littérature, nous pensons que l'utilisation de mégaprothèse du genou, constitue une solution efficace et durable pour le traitement des pseudarthroses du fémur distal et particulièrement chez le sujet âgé. Cette technique permet de répondre aux impératifs d'un tel aléa de la consolidation: lutter contre la douleur et garantir une mobilité satisfaisante permettant de répondre aux besoins de la vie quotidienne du patient et ainsi améliorer sa qualité de vie. PMID:24396555

Analyse de L'ancrage des Vortex Intergrains pour le Yttrium BARYUM(2) CUIVRE(3) OXYGENE(7) Polycristallin

NASA Astrophysics Data System (ADS)

Fournier, Patrick

Le Modele de l'Etat Critique Generalise (MECG) est utilise pour decrire les proprietes magnetiques et de transport du YBa_2Cu_3O _7 polycristallin. Ce modele empirique permet de relier la densite de courant critique a la densite de lignes de flux penetrant dans la region intergrain. Deux techniques de mesures sont utilisees pour caracteriser nos materiaux. La premiere consiste a mesurer le champ au centre d'un cylindre creux en fonction du champ magnetique applique pour des temperatures comprises entre 20 et 85K. En variant l'epaisseur de la paroi du cylindre creux, il est possible de suivre l'evolution des cycles d'hysteresis et de determiner des champs caracteristiques qui varient en fonction de cette dimension. En utilisant un lissage des resultats experimentaux, nous determinons J _{co}, H_ {o} et n, les parametres du MECG. La forme des cylindres, avec une longueur comparable au diametre externe, entrai ne la presence d'un champ demagnetisant qui peut etre inclus dans le modele theorique. Ceci nous permet d'evaluer la fraction du volume ecrante, f _{g}, ainsi que le facteur demagnetisant N. Nous trouvons que J_{ co}, H_{o} et f_{g} dependent de la temperature, tandis que n et N (pour une epaisseur de paroi fixe) n'en dependent pas. La deuxieme technique consiste a mesurer le courant critique de lames minces en fonction du champ applique pour differentes temperatures. Nous utilisons un montage que nous avons developpe permettant d'effectuer ces mesures en contact direct avec le liquide refrigerant, i.e. dans l'azote liquide. Nous varions la temperature du liquide en variant la pression du gaz au-dessus du bain d'azote. Cette methode nous permet de balayer des temperatures entre 65K et la temperature critique du materiau ({~ }92K). Nous effectuons le lissage des courbes de courant critique en fonction du champ applique encore a l'aide du MECG, pour a nouveau obtenir ses parametres. Pour trois echantillons avec des traitements thermiques differents, les parametres sont differents confirmant que la variation des proprietes macroscopiques de ces supraconducteurs est intimement reliee a la nature des jonctions entre les grains et de la surface des grains. L'oxygenation prolongee retablit les proprietes initiales des echantillons qui se sont degrades durant le recuit des contacts.

High-throughput and direct measurement of androgen levels using turbulent flow chromatography liquid chromatography-triple quadrupole mass spectrometry (TFC-LC-TQMS) to discover chemicals that modulate dihydrotestosterone production in human prostate cancer cells.

PubMed

Kang, Kyungsu; Peng, Lei; Jung, Yu-Jin; Kim, Joo Yeon; Lee, Eun Ha; Lee, Hee Ju; Kim, Sang Min; Sung, Sang Hyun; Pan, Cheol-Ho; Choi, Yongsoo

2018-02-01

To develop a high-throughput screening system to measure the conversion of testosterone to dihydrotestosterone (DHT) in cultured human prostate cancer cells using turbulent flow chromatography liquid chromatography-triple quadrupole mass spectrometry (TFC-LC-TQMS). After optimizing the cell reaction system, this method demonstrated a screening capability of 103 samples, including 78 single compounds and 25 extracts, in less than 12 h without manual sample preparation. Consequently, fucoxanthin, phenethyl caffeate, and Curcuma longa L. extract were validated as bioactive chemicals that inhibited DHT production in cultured DU145 cells. In addition, naringenin boosted DHT production in DU145 cells. The method can facilitate the discovery of bioactive chemicals that modulate the DHT production, and four phytochemicals are potential candidates of nutraceuticals to adjust DHT levels in male hormonal dysfunction.

Statistically Validated Networks in Bipartite Complex Systems

PubMed Central

Tumminello, Michele; Miccichè, Salvatore; Lillo, Fabrizio; Piilo, Jyrki; Mantegna, Rosario N.

2011-01-01

Many complex systems present an intrinsic bipartite structure where elements of one set link to elements of the second set. In these complex systems, such as the system of actors and movies, elements of one set are qualitatively different than elements of the other set. The properties of these complex systems are typically investigated by constructing and analyzing a projected network on one of the two sets (for example the actor network or the movie network). Complex systems are often very heterogeneous in the number of relationships that the elements of one set establish with the elements of the other set, and this heterogeneity makes it very difficult to discriminate links of the projected network that are just reflecting system's heterogeneity from links relevant to unveil the properties of the system. Here we introduce an unsupervised method to statistically validate each link of a projected network against a null hypothesis that takes into account system heterogeneity. We apply the method to a biological, an economic and a social complex system. The method we propose is able to detect network structures which are very informative about the organization and specialization of the investigated systems, and identifies those relationships between elements of the projected network that cannot be explained simply by system heterogeneity. We also show that our method applies to bipartite systems in which different relationships might have different qualitative nature, generating statistically validated networks in which such difference is preserved. PMID:21483858

VizieR Online Data Catalog: Star cluster Gaia 1 stars equivalent widths (Koch+, 2018)

NASA Astrophysics Data System (ADS)

Koch, A.; Hansen, T.; Kunder, A.

2017-09-01

Observations of four candidate members were taken during four nights in March 2017 using the Echelle spectrograph at the 2.5-m du Pont telescope at the Las Campanas Observatory, Chile, with a seeing of 0.7"-1.0" throughout the nights. Our spectroscopic set-up included a 1.0" slit with 2x1 binning in spectral and spatial dimensions, resulting in a resolving power of R~25000. (2 data files).

Neuron Learning to Network Organization.

DTIC Science & Technology

1983-12-20

02912 N 0-8 1t COTOLIGOF 1HV AflRS 12. REPORT OATE Pesne an ann Research Program December 20, 1983 Office of Naval Research , Code 442PT 13. NUMBER...visual cortc\\ from R. Cajal, Histologie du Systete Nerveux. mostly hard-wired and perform a great variety of control functions took hundreds of millions of...certain sense there is much that is known. A set of coupled non -linear differential equations. including time delays, can be written down that in

The steam laboratory of the Institut de Médecine Navale du Service de Santé des Armées: a set of tools in the service of the French Navy.

PubMed

Desruelle, Anne-Virginie; Schmid, Bruno

2004-09-01

Accidental exposure to hot water steam is a potential risk in the French Navy, and particularly on nuclear submarines or ships. Direct human exposure to this extreme environment during an accident leads to death in a short time. In order to protect the crew members of the French Navy, a laboratory was created at the Institut de Médecine Navale du Service de Santé des Armées (IMNSSA). A set of tools was developed to study the effects of exposure to hot water steam atmospheres on human physiology and on the protective capacities of textile fabrics and equipment. A testing device allows the quantification of the protective capacities of fabrics under steam stresses. A thermal manikin and a steam climatic chamber allow the evaluation of the protective capacities of equipment. The tests on fabrics and on garments were in good agreement. Water vapour impermeable fabrics and garments provide greater protection in steamy conditions. Moreover, the thicker the sample or garment, the higher the protection it gives. Care should be taken to verify that fabrics keep their thermal characteristics under steam stress. These characteristics, measured under standard comfortable conditions, are not always indicative of the protective abilities of the fabrics under steamy conditions.

Evidence of a long-term increase in tropospheric ozone from Pic du Midi data series: Consequences: Positive radiative forcing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marenco, A.; Gouget, H.; Nedelec, P.

1994-08-01

The rate at which ozone is increasing in the troposphere is uncertain due to the lack of accurate long-term measurements. Old ozone measurements obtained at the Pic du Midi Observatory (3000 m high, southwestern France) were recently rediscovered. Four sets of data available at this station are presented. The results show an increase in ozone by a factor of 5 since the beginning of the twentieth century, corresponding to an exponential increase of 1.6% per year, although this trend is probably higher (2.4% per year) for the last few decades. A stable 10 ppb ozone mixing ratio is observed duringmore » the first 20 years of the series, which is representative to the preindustrial era ozone level. The increase is seen to start around 1895. Other data, obtained at various European high-altitude stations between 1920 and 1980, tie in closely with the Pic du Midi observations. A tentative evaluation of the impact of tropospheric ozone on radiative forcing confirms that ozone is currently the second most significant greenhouse gas, responsible for 22% and 13% of radiative forcing changes since 1800 in the northern and southern hemispheres, respectively. If these rates were to be maintained in the future, ozone would continue to evolve differently in the two hemispheres (maximum level in the northern hemisphere) and could make an even more significant contribution to the radiative forcing of the northern hemisphere.« less

Numerical simulation of systems of shear bands in ductile metal with inclusions

NASA Astrophysics Data System (ADS)

Plohr, Jeeyeon

2017-06-01

We develop a method for numerical simulations of high strain-rate loading of mesoscale samples of ductile metal with inclusions. Because of its small-scale inhomogeneity, the composite material is prone to localized shear deformation. This method employs the Generalized Method of Cells to ensure that the micro mechanical behavior of the metal and inclusions is reflected properly in the behavior of the composite at the mesoscale. To find the effective plastic strain rate when shear bands are present, we extend and apply the analytic and numerical analysis of shear bands of Glimm, Plohr, and Sharp. Our tests of the method focus on the stress/strain response in uniaxial-strain flow, both compressive and tensile, of depleted uranium metal containing silicon carbide inclusions. In results, we verify the elevated temperature and thermal softening at shear bands in our simulations of pure DU and DU/SiC composites. We also note that in composites, due the asymmetry caused by the inclusions, shear band form at different times in different subcells. In particular, in the subcells near inclusions, shear band form much earlier than they do in pure DU.

Artificial recharge through a well in fissured carbonate rock, west St. Paul, Minnesota

USGS Publications Warehouse

Reeder, Harold O.; Wood, Warren W.; Ehrlich, G.G.; Sun, Ren Jen

1976-01-01

The injection test demonstrated that it is hydrologically feasible to recharge the Prairie du Chien Group and the Jordan Sandstone artificially through wells completed in the Prairie du Chien Group. The fissures in the Prairie du Chien Group act as conduits through which water spreads. The water passes into the Jordan Sandstone from the Prairie du Chien over a larger area than it would if it were injected directly into the Jordan.

Prevalence of duodenal ulcer-promoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population.

PubMed

Arachchi, H S Jayasinghe; Kalra, Vijay; Lal, Banwari; Bhatia, Vikram; Baba, C S; Chakravarthy, S; Rohatgi, S; Sarma, Priyangshu M; Mishra, V; Das, Bimal; Ahuja, Vineet

2007-12-01

The duodenal ulcer (DU)-promoting gene (dupA) of Helicobacter pylori has been identified as a novel virulent marker associated with an increased risk for DU. The presence or absence of dupA gene of H. pylori present in patients with DU and functional dyspepsia in North Indian population was studied by polymerase chain reaction (PCR) and hybridization analysis. One hundred and sixty-six patients (96 DU and 70 functional dyspepsia) were included in this study. In addition, sequence diversity of dupA gene of H. pylori found in these patients was analyzed by sequencing the PCR products jhp0917 and jhp0918 on both strands with appropriate primers. PCR and hybridization analyses indicated that dupA gene was present in 37.5% (36/96) of H. pylori strains isolated from DU patients and 22.86% (16/70) of functional dyspepsia patients (p < or = .05). Of these, 35 patients with DU (97.2%) and 14 patients with functional dyspepsia (81.25%) were infected by H. pylori positive for cagA genotype. Furthermore, the presence of dupA was significantly associated with the cagA-positive genotype (p < or = .02). Results of our study have shown that significant association of dupA gene with DU in this population. The dupA gene can be considered as a novel virulent marker for DU in this population.

Hazardous Waste Cleanup: DuPont Imaging Department in Parlin, New Jersey

EPA Pesticide Factsheets

DuPont has owned and operated a chemical manufacturing plant on Cheesequake Road in Parlin, New Jersey, since 1904. DuPont manufactured a variety of products at the plant including, photographic films, automotive paints, pigments, adhesives, thinners,

Peer assisted learning in the clinical setting: an activity systems analysis.

PubMed

Bennett, Deirdre; O'Flynn, Siun; Kelly, Martina

2015-08-01

Peer assisted learning (PAL) is a common feature of medical education. Understanding of PAL has been based on processes and outcomes in controlled settings, such as clinical skills labs. PAL in the clinical setting, a complex learning environment, requires fresh evaluation. Socio-cultural theory is proposed as a means to understand educational interventions in ways that are practical and meaningful. We describe the evaluation of a PAL intervention, introduced to support students' transition into full time clinical attachments, using activity theory and activity systems analysis (ASA). Our research question was How does PAL transfer to the clinical environment? Junior students on their first clinical attachments undertook a weekly same-level, reciprocal PAL activity. Qualitative data was collected after each session, and focus groups (n = 3) were held on completion. Data was analysed using ASA. ASA revealed two competing activity systems on clinical attachment; Learning from Experts, which students saw as the primary function of the attachment and Learning with Peers, the PAL intervention. The latter took time from the first and was in tension with it. Tensions arose from student beliefs about how learning takes place in clinical settings, and the importance of social relationships, leading to variable engagement with PAL. Differing perspectives within the group were opportunities for expansive learning. PAL in the clinical environment presents challenges specific to that context. Using ASA helped to describe student activity on clinical attachment and to highlight tensions and contradictions relating PAL in that setting. Planning learning opportunities on clinical placements, must take account of how students learn in workplaces, and the complexity of the multiple competing activity systems related to learning and social activities.

Can preoperative detrusor underactivity influence surgical outcomes of 120 W HPS vaporization of the prostate (PVP) or holmium laser enucleation of the prostate (HoLEP)? A serial 3-year follow-up study.

PubMed

Cho, Min Chul; Park, Juhyun; Kim, Jung Kwon; Cho, Sung Yong; Jeong, Hyeon; Oh, Seung-June; Paick, Jae-Seung; Son, Hwancheol

2018-01-01

To determine the influence of preoperative detrusor underactivity (DU) on serial long-term outcomes of HPS/PVP or HoLEP for LUTS/BPH, and to compare the influence between the two surgeries. A total of 382 men, who underwent 120W-HPS/PVP or HoLEP for LUTS/BPH and for whom 36-month follow-up data were available, were classified into four groups: HPS with DU (n = 145), HPS without DU (n = 44), HoLEP with DU (n = 105), and HoLEP without DU (n = 88). DU was defined as bladder contractility index of <100. Surgical outcomes were assessed at postoperative 6, 12, 24, and 36 months using IPSS, uroflowmetry, and serum PSA. All four groups maintained improvements in voiding symptom score (VSS), storage symptom score, total-IPSS, QOL index, maximum flow rate (Qmax), post-void residual urine volume (PVR), and bladder voiding efficiency (BVE) compared with baseline up to 3 years postoperatively. There were no significant differences in improvements of postoperative IPSS parameters including QOL index between men with and without DU throughout the follow-up period after HPS or HoLEP. In men with DU, there were no significant differences in improvements of postoperative QOL index, Qmax, PVR, or BVE between HPS and HoLEP groups throughout the follow-up period, except for VSS and total IPSS. Serum PSA reductions after HoLEP were greater than after PVP. Improvements in LUTS, Qmax, and BVE can maintain up to 3 years after HPS or HoLEP for LUTS/BPH, irrespective of the presence or absence of preoperative DU. Although HoLEP may provide more durable improvement of VS in men with DU than HPS, there seems to be no difference in improvement of QOL or Qmax or BVE between HPS and HoLEP. © 2017 Wiley Periodicals, Inc.

Application of DuPont photopolymer films to automotive holographic display

NASA Astrophysics Data System (ADS)

Nakazawa, Norihito; Ono, Motoshi; Takeuchi, Shoichi; Sakurai, Hiromi; Hirano, Masahiro

1998-03-01

Automotive holographic head-up display (HUD) systems employing DuPont holographic photopolymer films are presented. Holographic materials for automotive application are exposed to severe environmental conditions and are required high performance. This paper describes the improvement of DuPont photopolymer films for the automotive use, critical technical issues such as optical design, external color and stray light. The holographic HUD combiner embedded in a windshield of an automobile has peculiar problems called external color. Diffraction light from holographic combiner makes its external color tone stimulative. We have introduced RGB three color recording and color simulation in order to improve the external color. A moderate external color tone was realized by the optimization in terms of wavelengths and diffraction efficiencies of the combiner hologram. The stray light called flare arises from a reflection by glass surface of windshield. We have developed two techniques to avoid the flare. First is a diffuser type trap beam guard hologram which reduces the intensity of the flare. Second is the optimization of the design of hologram so that the incident direction of flare is lower than the horizon line. As an example of automotive display a stand-alone type holographic HUD system attached on the dashboard of an automobile is demonstrated, which provides useful driving information such as route guidance. The display has a very simple optical system that consists of only a holographic combiner and a vacuum fluorescent display. Its thin body is only 35 mm high and does not obstruct driver's view. The display gives high contrast and wide image.

Long-term Evaluation of Landuse Changes On Landscape Water Balance - A Case Study From North-east Germany

NASA Astrophysics Data System (ADS)

Wegehenkel, M.

In this paper, long-term effects of different afforestation scenarios on landscape wa- ter balance will be analyzed taking into account the results of a regional case study. This analysis is based on using a GIS-coupled simulation model for the the spatially distributed calculation of water balance.For this purpose, the modelling system THE- SEUS with a simple GIS-interface will be used. To take into account the special case of change in forest cover proportion, THESEUS was enhanced with a simple for- est growth model. In the regional case study, model runs will be performed using a detailed spatial data set from North-East Germany. This data set covers a mesoscale catchment located at the moraine landscape of North-East Germany. Based on this data set, the influence of the actual landuse and of different landuse change scenarios on water balance dynamics will be investigated taking into account the spatial distributed modelling results from THESEUS. The model was tested using different experimen- tal data sets from field plots as well as obsverded catchment discharge. Additionally to such convential validation techniques, remote sensing data were used to check the simulated regional distribution of water balance components like evapotranspiration in the catchment.

Combining cognitive engineering and information fusion architectures to build effective joint systems

NASA Astrophysics Data System (ADS)

Sliva, Amy L.; Gorman, Joe; Voshell, Martin; Tittle, James; Bowman, Christopher

2016-05-01

The Dual Node Decision Wheels (DNDW) architecture concept was previously described as a novel approach toward integrating analytic and decision-making processes in joint human/automation systems in highly complex sociotechnical settings. In this paper, we extend the DNDW construct with a description of components in this framework, combining structures of the Dual Node Network (DNN) for Information Fusion and Resource Management with extensions on Rasmussen's Decision Ladder (DL) to provide guidance on constructing information systems that better serve decision-making support requirements. The DNN takes a component-centered approach to system design, decomposing each asset in terms of data inputs and outputs according to their roles and interactions in a fusion network. However, to ensure relevancy to and organizational fitment within command and control (C2) processes, principles from cognitive systems engineering emphasize that system design must take a human-centered systems view, integrating information needs and decision making requirements to drive the architecture design and capabilities of network assets. In the current work, we present an approach for structuring and assessing DNDW systems that uses a unique hybrid DNN top-down system design with a human-centered process design, combining DNN node decomposition with artifacts from cognitive analysis (i.e., system abstraction decomposition models, decision ladders) to provide work domain and task-level insights at different levels in an example intelligence, surveillance, and reconnaissance (ISR) system setting. This DNDW structure will ensure not only that the information fusion technologies and processes are structured effectively, but that the resulting information products will align with the requirements of human decision makers and be adaptable to different work settings .

Entkolonialisierung der Erziehung — das Beispiel Der VR Kongo

NASA Astrophysics Data System (ADS)

Radtke, Frank-Olaf; Gstettner, Peter; Streiffeler, Friedhelm

1981-03-01

The first part of this contribution attempts to recapitulate the economic and social conditions facing educational policy in post-colonial Africa. The second part shows that the dependence on world economy is aggravated by the separation of education from productive work, which is a concomitant of the institutionalisation of education. In the communally-organised traditional African societies, education was incumbent on all members of the society; it was part of the common life-and-work process. It was not until the school as institution had been introduced that education came to be governed by the principles of the division of labour and took over the function of the selection and creation of privilege. This has led to an alientation of school leavers from productive work. The educational system as a whole can no longer support those societal tasks that require creativity and development. Following a phase of quantitative expansion, the third part points out that African educational policy is currently making great efforts to give the educational system a qualitative reorientation towards the real needs of African societies. The fourth part describes the detachment from Euro-American strategies of development and innovation, and the revaluation of elements of traditional education. Taking as an example the programme, `Ecole du peuple', which aims to reorganise the educational system of the People's Republic of the Congo from pre-school to university, the difficulties of such an undertaking are investigated.

Learning-Focused Leadership and Leadership Support: Meaning and Practice in Urban Systems

ERIC Educational Resources Information Center

Knapp, Michael S.; Copland, Michael A.; Honig, Meredith I.; Plecki, Margaret L.; Portin, Bradley S.

2010-01-01

This report synthesizes what has been learned about how leaders in urban systems focus their leadership on the improvement of learning, and what it takes to support their leadership in these settings. The report brings together findings from three sub-study strands, concerned with efforts in seven urban districts to: a) invest staffing and other…

CFD Simulations of a Ferry in Head Seas

DTIC Science & Technology

2011-03-01

la durée de vie en fatigue globale du navire. Il est important, pour la conception, l’exploitation et la gestion du cycle de ...vibration de frottement qui exerce une contrainte sur la structure de coque primaire et qui a un effet défavorable sur la durée de vie en fatigue globale du ...laquelle ne peut simuler directement la physique du tossage. Le présent rapport contient les résultats d’une étude faisant

Development of Measures of Effectiveness and Performance from Cognitive Work Analysis Products

DTIC Science & Technology

2012-02-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2012 DRDC Atlantic CR 2011...le nouveau concept du système. Ce rapport vise à déterminer si les résultats du travail de conception peuvent aider à élaborer des mesures de ...l’information (IIDS). Le contrat actuel comportait deux objectifs : élaborer des mesures de l’efficacité (MOE) et du rendement (MOP) pour

V2010 Security Planning and Operations: A Social Network Study of Key Information Sharing Relationships

DTIC Science & Technology

2011-05-01

la scurit. Je vous remercie de votre temps et de votre contribution. Susan G. McIntyre Knowledge Management/ Gestion du savoir...National Defence, 2011 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 DRDC CSS TR 2011...avantages du renforcement de la communication horizontale au sein du gouvernement fédéral, surtout en présence d’organismes de

Depleted uranium: properties, military use and health risks.

PubMed

Fairlie, Ian

2009-01-01

This article describes uranium and depleted uranium (DU), their similar isotopic compositions, how DU arises, its use in munitions and armour-proofing, and its pathways for human exposures. Particular attention is paid to the evidence of DU's health effects from cell and animal experiments and from epidemiology studies. It is concluded that a precautionary approach should be adopted to DU and that there should be a moratorium on its use by military forces. International efforts to this end are described.

Iao: The New Adaptive Optics Visible Imaging and Photometric System for AEOS

DTIC Science & Technology

2008-09-01

observations of binary stars, asteroids and planets such as Mercury and Mars [2,3,4]. The Visible Imager is also used to take time resolved photometry ...role it takes high spatial resolution imagery of resolved targets. These targets are primarily low Earth orbiting satellites acquired for the...albedo pattern: Comparing the AEOS and TES data sets [5] D.T. Hall et al. 2007, Journal of Spacecraft and Rockets, 44, 910-919, Time - Resolved I-Band

Etude de la performance des radars hautes-frequences CODAR et WERA pour la mesure des courants marins en presence partielle de glace de mer

NASA Astrophysics Data System (ADS)

Kamli, Emna

Les radars hautes-frequences (RHF) mesurent les courants marins de surface avec une portee pouvant atteindre 200 kilometres et une resolution de l'ordre du kilometre. Cette etude a pour but de caracteriser la performance des RHF, en terme de couverture spatiale, pour la mesure des courants de surface en presence partielle de glace de mer. Pour ce faire, les mesures des courants de deux radars de type CODAR sur la rive sud de l'estuaire maritime du Saint-Laurent, et d'un radar de type WERA sur la rive nord, prises pendant l'hiver 2013, ont ete utilisees. Dans un premier temps, l'aire moyenne journaliere de la zone ou les courants sont mesures par chaque radar a ete comparee a l'energie des vagues de Bragg calculee a partir des donnees brutes d'acceleration fournies par une bouee mouillee dans la zone couverte par les radars. La couverture des CODARs est dependante de la densite d'energie de Bragg, alors que la couverture du WERA y est pratiquement insensible. Un modele de fetch appele GENER a ete force par la vitesse du vent predite par le modele GEM d'Environnement Canada pour estimer la hauteur significative ainsi que la periode modale des vagues. A partir de ces parametres, la densite d'energie des vagues de Bragg a ete evaluee pendant l'hiver a l'aide du spectre theorique de Bretschneider. Ces resultats permettent d'etablir la couverture normale de chaque radar en absence de glace de mer. La concentration de glace de mer, predite par le systeme canadien operationnel de prevision glace-ocean, a ete moyennee sur les differents fetchs du vent selon la direction moyenne journaliere des vagues predites par GENER. Dans un deuxieme temps, la relation entre le ratio des couvertures journalieres obtenues pendant l'hiver 2013 et des couvertures normales de chaque radar d'une part, et la concentration moyenne journaliere de glace de mer d'autre part, a ete etablie. Le ratio des couvertures decroit avec l'augmentation de la concentration de glace de mer pour les deux types de radars, mais pour une concentration de glace de 20% la couverture du WERA est reduite de 34% alors que pour les CODARs elle est reduite de 67%. Les relations empiriques etablies entre la couverture des RHF et les parametres environnementaux (vent et glace de mer) permettront de predire la couverture que pourraient fournir des RHF installes dans d'autres regions soumises a la presence saisonniere de glace de mer.

Fissuration d'un composite a matrice ceramique dans une application de piece statique de turbine a gaz

NASA Astrophysics Data System (ADS)

Lebel, Larry

Une procedure experimentale a ete developpee pour caracteriser les mecanismes de deterioration et la durabilite de materiaux composites a matrice ceramique (CMC) dans une application de piece statique de turbine a gaz. Tandis que la plupart des essais de caracterisation publies sur les materiaux CMC ont ete realises sous des conditions de chargement controle, la presente recherche tente de reproduire la relaxation des contraintes qui se produit normalement dans une piece statique a haute temperature. Dans l'experience proposee, un echantillon planaire de forme haltere est chauffe de facon cyclique sur une de ses faces et refroidi sur l'autre, tout en etant contraint dans ses deplacements. La contrainte de flexion resultante au centre de l'echantillon, mesuree par une cellule de charge, correspond a la contrainte de flexion qui a ete prealablement predite au centre des panneaux d'une chambre a combustion generique. Un materiau CMC multicouche compose d'une matrice d'alumine poreuse et de fibres NextelMD 720 a ete utilise pour developper l'experience. Des essais de calibration ont d'abord ete realises en utilisant un systeme de chauffage par lampe infrarouge, atteignant jusqu'a 1160 °C a la surface de l'echantillon. Un systeme laser au CO2 a par la suite ete utilise pour realiser des essais de deterioration a haute puissance, atteignant en fin d'essai des temperatures de surface excedant la limite de 1200 °C du materiau et des differences de temperature a travers l'epaisseur de plus de 1000 °C. Sous la puissance de chauffage imposee a amplitude constante, l'accumulation de dommage a fait en sorte d'augmenter la temperature en surface et les gradients de temperature a travers le materiau. Une reduction de la contrainte dans le temps a ete observee a cause du fluage, de la fissuration et de la delamination du materiau sous la condition de confinement du deplacement, menant a une stabilisation du niveau de dommage a une certaine profondeur dependant de la contrainte thermique initiale. La procedure de caracterisation developpee s'avere etre un outil prometteur pour developper de nouveaux types de materiaux, de meme que pour comparer la durabilite de materiaux existants sous des conditions representatives de pieces statiques de turbine a gaz. None

In vivo detection of hyperoxia-induced pulmonary endothelial cell death using (99m)Tc-duramycin.

PubMed

Audi, Said H; Jacobs, Elizabeth R; Zhao, Ming; Roerig, David L; Haworth, Steven T; Clough, Anne V

2015-01-01

(99m)Tc-duramycin, DU, is a SPECT biomarker of tissue injury identifying cell death. The objective of this study is to investigate the potential of DU imaging to quantify capillary endothelial cell death in rat lung injury resulting from hyperoxia exposure as a model of acute lung injury. Rats were exposed to room air (normoxic) or >98% O2 for 48 or 60 hours. DU was injected i.v. in anesthetized rats, scintigraphy images were acquired at steady-state, and lung DU uptake was quantified from the images. Post-mortem, the lungs were removed for histological studies. Sequential lung sections were immunostained for caspase activation and endothelial and epithelial cells. Lung DU uptake increased significantly (p<0.001) by 39% and 146% in 48-hr and 60-hr exposed rats, respectively, compared to normoxic rats. There was strong correlation (r(2)=0.82, p=0.005) between lung DU uptake and the number of cleaved caspase 3 (CC3) positive cells, and endothelial cells accounted for more than 50% of CC3 positive cells in the hyperoxic lungs. Histology revealed preserved lung morphology through 48 hours. By 60 hours there was evidence of edema, and modest neutrophilic infiltrate. Rat lung DU uptake in vivo increased after just 48 hours of >98% O2 exposure, prior to the onset of any substantial evidence of lung injury. These results suggest that apoptotic endothelial cells are the primary contributors to the enhanced DU lung uptake, and support the utility of DU imaging for detecting early endothelial cell death in vivo. Copyright © 2014 Elsevier Inc. All rights reserved.

Short-term dynamics of intertidal microphytobenthic biomass. Mathematical modelling [La dynamique a court terme de la biomasse du microphytobenthos intertidal. Formalisation mathematique

USGS Publications Warehouse

Guarini, J.-M.; Gros, P.; Blanchard, G.F.; Bacher, C.

1999-01-01

We formulate a deterministic mathematical model to describe the dynamics of the microphytobenthos of intertidal mudflats. It is 'minimal' because it only takes into account the essential processes governing the functioning of the system: the autotrophic production, the active upward and downward migrations of epipelic microalgae, the saturation of the mud surface by a biofilm of diatoms and the global net loss rates of biomass. According to the photic environment of the benthic diatoms inhabiting intertidal mudflats, and to their migration rhythm, the model is composed of two sub-systems of ordinary differential equations; they describe the simultaneous evolution of the biomass 'S' concentrated in the mud surface biofilm - the photic layer - and of the biomass 'F' diluted in the topmost centimetre of the mud - the aphotic layer. Qualitatively, the model solutions agree fairly well with the in situ observed dynamics of the S + F biomass. The study of the mathematical properties of the model, under some simplifying assumptions, shows the convergence of solutions to a stable cyclic equilibrium, whatever the frequencies of the physical synchronizers of the production. The sensitivity analysis reveals the necessity of a better knowledge of the processes of biomass losses, which so far are uncertain, and may further vary in space and time.

W. E. B. Du Bois at the center: from science, civil rights movement, to Black Lives Matter.

PubMed

Morris, Aldon

2017-03-01

I am honoured to present the 2016 British Journal of Sociology Annual Lecture at the London School of Economics. My lecture is based on ideas derived from my new book, The Scholar Denied: W.E.B. Du Bois and the Birth of Modern Sociology. In this essay I make three arguments. First, W.E.B. Du Bois and his Atlanta School of Sociology pioneered scientific sociology in the United States. Second, Du Bois pioneered a public sociology that creatively combined sociology and activism. Finally, Du Bois pioneered a politically engaged social science relevant for contemporary political struggles including the contemporary Black Lives Matter movement. © London School of Economics and Political Science 2017.

The du Bois sign.

PubMed

Voelpel, James H; Muehlberger, Thomas

2011-03-01

According to the current literature, the term "du Bois sign" characterizes the condition of a shortened fifth finger as a symptom of congenital syphilis, Down syndrome, dyscrania, and encephalic malformation. Modern medical dictionaries and text books attribute the eponym to the French gynecologist Paul Dubois (1795-1871). Yet, a literature analysis revealed incorrect references to the person and unclear definitions of the term. Our findings showed that the origin of the term is based on observations made by the Swiss dermatologist Charles du Bois (1874-1947) in connection with congenital syphilis. In addition, a further eponymical fifth finger sign is closely associated with the du Bois sign. In conclusion, the du Bois sign has only limited diagnostic value and is frequently occurring in the normal healthy population.

Révision de la sous-famille des Metaracoelophryinae de Puytorac 1972 (Oligohymenophora : Hoplytophryida : Hoplytophryidae), ciliés astomes du tube digestif d’oligochètes terricoles d’Afrique : description de cinq espèces nouvelles

PubMed Central

Fokam, Z.; Ngassam, P.; Nana, P.A.; Bricheux, G.; Bouchard, P.; Sime Ngando, T.

2012-01-01

Cinq nouvelles espèces de ciliés astomes, présentes dans le tube digestif de vers oligochètes du genre Alma du Cameroun, ont été décrites. Les techniques utilisées sont : l’observation vitale, la coloration au DAPI, la microscopie électronique à balayage et les imprégnations argentiques selon Fernandez Galiano, 1966. Ce travail confirme la présence des genres Paracoelophrya et Dicoelophrya dans le tube digestif des oligochètes du genre Alma du Gabon et du Cameroun ; il permet de faire une synthèse récapitulative de la sous-famille des Metaracoelophryinae. De plus, est confirmée l’homogénéité de ce groupe, et est reposée la question de la parenté phylogénétique des Hoplitophryida. PMID:22314239

An investigation of duck circovirus and co-infection in Cherry Valley ducks in Shandong Province, China.

PubMed

Zhang, Xingxiao; Jiang, Shijin; Wu, Jiaqiang; Zhao, Qin; Sun, Yani; Kong, Yibo; Li, Xiaoxia; Yao, Meiling; Chai, Tongjie

2009-01-13

The co-infection of duck circovirus (DuCV) with Riemerella anatipestifer (RA) or/and Escherichia coli (E. coli) or/and duck hepatitis virus I (DHV-I) in Cherry Valley ducks in China's Shandong Province was investigated by using polymerase-chain-reaction (PCR)-based methods. For this study, 742 ducks sampled at random from 70 duck farms during 2006-2007 were examined using PCR and dot-blot hybridisation (DBH) tests. Overall the DuCV infection rate was 33.29%. Compared with those at 2 weeks of age, the ducks at 3-4 weeks of age were more susceptible to DuCV infection. Compared with the DuCV-negative ones, the DuCV-positive ducks had a higher rate of infection by DHV-I (25.5% vs. 7.475%), RA (23.48% vs. 8.28%) and E. coli (16.19% vs. 4.85%). This investigation shows that DuCV infection is common in Cherry Valley ducks on some farms in Shandong Province.

The Helicobacter pylori duodenal ulcer promoting gene, dupA in China.

PubMed

Zhang, Zhiyu; Zheng, Qing; Chen, Xiaoyu; Xiao, Shudong; Liu, Wenzhong; Lu, Hong

2008-10-25

The prevalence of H. pylori is as high as 60-70% in Chinese population. Although duodenal ulcer and gastric cancer are both caused by H. pylori, they are at opposite ends of the spectrum and as such are considered mutually exclusive. Duodenal ulcer promoting (dupA) gene was reported to be associated with duodenal ulcer development. The aim of this study was to determine the prevalence of dupA gene of Helicobacter pylori in patients with various gastroduodenal diseases and to explore the association between the gene and other virulence factors. H. pylori were isolated from gastric biopsies of patients with chronic gastritis, duodenal ulcer (DU), gastric ulcer (GU), or non-cardia gastric carcinoma. The dupA, cagA, vacA, iceA and babA2 genotypes were determined by polymerase chain reaction. Histological features of gastric mucosal biopsy specimens were graded based on the scoring system proposed by the updated Sydney system. IL-1beta polymorphism was investigated using restriction fragment length polymorphism. Isolates from 360 patients including 133 with chronic gastritis, 101 with DU, 47 with GU, and 79 with non-cardia gastric carcinoma were examined. The dupA gene was detected in 35.3% (127/360) and the prevalence DU patients was significantly greater than that in gastric cancer or GU patients (45.5% vs. 24.1% and 23.4%, P < 0.05). Patients infected with dupA-positive strains had higher scores for chronic inflammation compared to those with dupA-negative strains (2.36 vs. 2.24, p = 0.058). The presence of dupA was not associated with the cagA, vacA, iceA and babA 2 genotypes or with IL-1beta polymorphisms. In China the prevalence of dupA gene was highest in DU and inversely related to GU and gastric cancer.

Efficacy of sildenafil on ischaemic digital ulcer healing in systemic sclerosis: the placebo-controlled SEDUCE study

PubMed Central

Hachulla, Eric; Hatron, Pierre-Yves; Carpentier, Patrick; Agard, Christian; Chatelus, Emmanuel; Jego, Patrick; Mouthon, Luc; Queyrel, Viviane; Fauchais, Anne-Laure; Michon-Pasturel, Ulrique; Jaussaud, Roland; Mathian, Alexis; Granel, Brigitte; Diot, Elisabeth; Farge-Bancel, Dominique; Mekinian, Arsène; Avouac, Jérôme; Desmurs-Clavel, Hélène; Clerson, Pierre

2016-01-01

Objective To assess the effect of sildenafil, a phosphodiesterase type 5 inhibitor, on digital ulcer (DU) healing in systemic sclerosis (SSc). Methods Randomised, placebo-controlled study in patients with SSc to assess the effect of sildenafil 20 mg or placebo, three times daily for 12 weeks, on ischaemic DU healing. The primary end point was the time to healing for each DU. Time to healing was compared between groups using Cox models for clustered data (two-sided tests, p=0.05). Results Intention-to-treat analysis involved 83 patients with a total of 192 DUs (89 in the sildenafil group and 103 in the placebo group). The HR for DU healing was 1.33 (0.88 to 2.00) (p=0.18) and 1.27 (0.85 to 1.89) (p=0.25) when adjusted for the number of DUs at entry, in favour of sildenafil. In the per protocol population, the HRs were 1.49 (0.98 to 2.28) (p=0.06) and 1.43 (0.93 to 2.19) p=0.10. The mean number of DUs per patient was lower in the sildenafil group compared with the placebo group at week (W) 8 (1.23±1.61 vs 1.79±2.40 p=0.04) and W12 (0.86±1.62 vs 1.51±2.68, p=0.01) resulting from a greater healing rate (p=0.01 at W8 and p=0.03 at W12). Conclusions The primary end point was not reached in intention-to-treat, partly because of an unexpectedly high healing rate in the placebo group. We found a significant decrease in the number of DUs in favour of sildenafil compared with placebo at W8 and W12, confirming a sildenafil benefit. Trial registration number NCT01295736. PMID:25995322

Detection of severe digital vasculopathy in systemic sclerosis by colour Doppler sonography is associated with digital ulcers.

PubMed

Lüders, Susanne; Friedrich, Stefanie; Ohrndorf, Sarah; Glimm, Anne-Marie; Burmester, Gerd-Rüdiger; Riemekasten, Gabriela; Backhaus, Marina

2017-11-01

Colour Doppler ultrasonography (CDUS) is very important in general vascular diagnostic procedures. Its role in determining the extent of vasculopathy in Systemic Sclerosis (SSc) needs further investigation. The aim of this study was to compare the presence of altered arteries with nailfold capillaroscopy and clinical signs of ischaemia, that is, digital ulcers or pitting scars (DU/PS). A feasible CDUS protocol is provided. Two thousand five hundred and twenty-eight arteries of the fingers, palms and wrists from 79 SSc patients (32 arteries per patient) were examined using CDUS. Furthermore, nailfold capillaroscopy, clinical and laboratory data were evaluated. Narrowed or occluded lumens were seen in 39.8% of all assessable arteries (n = 2489) and 48.9% of all proper palmar digital arteries (n = 1564) but only 15.6% (P < 0.0001) of proximal arteries (n = 924). Fingerwise analyses presented significant coincidence of pathological CDUS findings and DU/PS (P = 0.0009). Pathological CDUS findings were also associated with elevated CRP concentrations, current or past smoking with ⩾20 pack-years, male gender and present or past DU/PS. Receiver operating characteristic curve analysis (area under the curve = 0.727) suggested a cut-off value of ⩾20% pathological vessels (sensitivity: 90.7%; specificity: 47.8%) for the presence of DU/PS. An examination protocol focusing on the right-hand digits II-V (proper palmar digital arteries) revealed similar results (area under the curve = 0.751; sensitivity: 93.0%; specificity: 43.5%). CDUS of hand and finger arteries allows measurement of the extent of SSc vasculopathy, which is associated with clinical signs of chronic malperfusion. A shortened examination protocol of CDUS (right-hand digits II-V; 15 min instead of 45 min examination time) could complement vascular diagnostics in SSc. © The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com

The Helicobacter pylori duodenal ulcer promoting gene, dupA in China

PubMed Central

Zhang, Zhiyu; Zheng, Qing; Chen, Xiaoyu; Xiao, Shudong; Liu, Wenzhong; Lu, Hong

2008-01-01

Background The prevalence of H. pylori is as high as 60–70% in Chinese population. Although duodenal ulcer and gastric cancer are both caused by H. pylori, they are at opposite ends of the spectrum and as such are considered mutually exclusive. Duodenal ulcer promoting (dupA) gene was reported to be associated with duodenal ulcer development. The aim of this study was to determine the prevalence of dupA gene of Helicobacter pylori in patients with various gastroduodenal diseases and to explore the association between the gene and other virulence factors. Methods H. pylori were isolated from gastric biopsies of patients with chronic gastritis, duodenal ulcer (DU), gastric ulcer (GU), or non-cardia gastric carcinoma. The dupA, cagA, vacA, iceA and babA2 genotypes were determined by polymerase chain reaction. Histological features of gastric mucosal biopsy specimens were graded based on the scoring system proposed by the updated Sydney system. IL-1β polymorphism was investigated using restriction fragment length polymorphism. Results Isolates from 360 patients including 133 with chronic gastritis, 101 with DU, 47 with GU, and 79 with non-cardia gastric carcinoma were examined. The dupA gene was detected in 35.3% (127/360) and the prevalence DU patients was significantly greater than that in gastric cancer or GU patients (45.5% vs. 24.1% and 23.4%, P < 0.05). Patients infected with dupA-positive strains had higher scores for chronic inflammation compared to those with dupA-negative strains (2.36 vs. 2.24, p = 0.058). The presence of dupA was not associated with the cagA, vacA, iceA and babA 2 genotypes or with IL-1β polymorphisms. Conclusion In China the prevalence of dupA gene was highest in DU and inversely related to GU and gastric cancer. PMID:18950522

Angiogenic T cell expansion correlates with severity of peripheral vascular damage in systemic sclerosis.

PubMed

Manetti, Mirko; Pratesi, Sara; Romano, Eloisa; Bellando-Randone, Silvia; Rosa, Irene; Guiducci, Serena; Fioretto, Bianca Saveria; Ibba-Manneschi, Lidia; Maggi, Enrico; Matucci-Cerinic, Marco

2017-01-01

The mechanisms underlying endothelial cell injury and defective vascular repair in systemic sclerosis (SSc) remain unclear. Since the recently discovered angiogenic T cells (Tang) may have an important role in the repair of damaged endothelium, this study aimed to analyze the Tang population in relation to disease-related peripheral vascular features in SSc patients. Tang (CD3+CD31+CXCR4+) were quantified by flow cytometry in peripheral blood samples from 39 SSc patients and 18 healthy controls (HC). Circulating levels of the CXCR4 ligand stromal cell-derived factor (SDF)-1α and proangiogenic factors were assessed in paired serum samples by immunoassay. Serial skin sections from SSc patients and HC were subjected to CD3/CD31 and CD3/CXCR4 double immunofluorescence. Circulating Tang were significantly increased in SSc patients with digital ulcers (DU) compared either with SSc patients without DU or with HC. Tang levels were significantly higher in SSc patients with late nailfold videocapillaroscopy (NVC) pattern than in those with early/active NVC patterns and in HC. No difference in circulating Tang was found when comparing either SSc patients without DU or patients with early/active NVC patterns and HC. In SSc peripheral blood, Tang percentage was inversely correlated to levels of SDF-1α and CD34+CD133+VEGFR-2+ endothelial progenitor cells (EPC), and positively correlated to levels of vascular endothelial growth factor and matrix metalloproteinase-9. Tang were frequently detected in SSc dermal perivascular inflammatory infiltrates. In summary, our findings demonstrate for the first time that Tang cells are selectively expanded in the circulation of SSc patients displaying severe peripheral vascular complications like DU. In SSc, Tang may represent a potentially useful biomarker reflecting peripheral vascular damage severity. Tang expansion may be an ineffective attempt to compensate the need for increased angiogenesis and EPC function. Further studies are required to clarify the function of Tang cells and investigate the mechanisms responsible for their change in SSc.

Products of in Situ Corrosion of Depleted Uranium Ammunition in Bosnia and Herzegovina Soils.

PubMed

Wang, Yuheng; von Gunten, Konstantin; Bartova, Barbora; Meisser, Nicolas; Astner, Markus; Burger, Mario; Bernier-Latmani, Rizlan

2016-11-15

Hundreds of tons of depleted uranium (DU) ammunition were used in previous armed conflicts in Iraq, Bosnia and Herzegovina, and Serbia/Kosovo. The majority (>90%) of DU penetrators miss their target and, if left in the environment, corrode in these postconflict zones. Thus, the best way to understand the fate of bulk DU material in the environment is to characterize the corrosion products of intact DU penetrators under field conditions for extended periods of time. However, such studies are scarce. To fill this knowledge gap, we characterized corrosion products formed from two intact DU penetrators that remained in soils in Bosnia and Herzegovina for over seven years. We used a combination of X-ray powder diffraction, electron microscopy, and X-ray absorption spectroscopy. The results show that metaschoepite (UO 3 (H 2 O) 2 ) was a main component of the two DU corrosion products. Moreover, studtite ((UO 2 )O 2 (H 2 O) 2 ·2(H 2 O)) and becquerelite (Ca(UO 2 ) 6 O 4 (OH) 6 ·8(H 2 O)) were also identified in the corrosion products. Their formation through transformation of metaschoepite was a result of the geochemical conditions under which the penetrators corroded. Moreover, we propose that the transformation of metaschoepite to becquerelite or studtite in the DU corrosion products would decrease the potential for mobilization of U from corroded DU penetrators exposed to similar environments in postconflict areas.

Are dentists enough aware of infectious risk associated with dental unit waterlines ?

PubMed

Robert, Amélie; Bousseau, Anne; Costa, Damien; Barbot, Vanessa; Imbert, Christine

2013-07-10

Environmental conditions in DU encourage biofilm development. This biofilm may represent a risk for patients and dental staff exposed to water and aerosols generated during dental cares, particularly for immunocompromised persons. A survey was conducted on the 175 dental surgeons of the department of Vienne (France) to investigate the motivations of dental practitioners to renew their DU, their awareness levels with respect to infectious risks related to water circulating within DU, and methods used for the maintenance of DU waterlines. These dentists were only partially aware of the need for maintaining DU waterlines. For this maintaining, chemical treatments and purges of pipes were carried out by 88% and 91.5% of dentists respectively ; chemical treatments were usually on a continous mode and dentists seemed to have complete confidence in their DU supplier regarding the choice and the use of chemical treatments. Flushes were performed only once per day in most cases (63%). This survey also highlighted that dentists were not enough aware of water related infectous risk, even though 68% estimated that the development of a biofilm within DU waterlines was an actual risk. Finally, very positively, dentists strongly indicated their wish to be more informed regarding all these risks. Although these results are based on a relatively small sample, corresponding to dentists of a French department, they clearly suggest that awareness of dental surgeons is still insufficient and must be performed to permit an effective prevention of infectious risk related to DU waterlines.

Software Epistemology

DTIC Science & Technology

2016-03-01

in-vitro decision to incubate a startup, Lexumo [7], which is developing a commercial Software as a Service ( SaaS ) vulnerability assessment...LTS Label Transition System MUSE Mining and Understanding Software Enclaves RTEMS Real-Time Executive for Multi-processor Systems SaaS Software ...as a Service SSA Static Single Assignment SWE Software Epistemology UD/DU Def-Use/Use-Def Chains (Dataflow Graph)

[Multidisciplinary team meetings settings on the management of women at high risk of inherited breast cancer. A French study].

PubMed

Gillmann, Fanchon; Cordier, Christophe; Taris, Nicolas; Mathelin, Carole; Maugard, Christine M

2016-06-01

In France, 126 centers for cancer genetics coordinate genetic testing and high-risk cancer surveillance for individuals and their families with hereditary cancer syndromes. Since 2012, the French National Cancer Institute (INCa) supports 17 projects to promote and manage the monitoring of individuals genetically predisposed to cancer. They were assigned 4 missions by INCa including expertise for difficult cases. We initiated a national survey to assess how the oncogenetic clinics responded to the 4th mission for women at high risk of developing breast cancers. We sent the survey to all the French oncogeneticists. We aimed at evaluating the modalities and the extent of implementation of the Multidisciplinary team (MDT) meetings regarding the management of women who have genetically higher risks to develop breast cancer. Fourteen people from 12 administrative regions, who represent 10 of the 17 projects, answered the form. Eleven participants reported the submission of medical cases in Oncogenetics MDT meetings (79 %), 5 in senology MDT meetings (36 %), 5 in MDT meetings dedicated to patients at high risk for breast cancer (36 %) and 2 in network meetings (14 %). Some structures discuss medical cases through different MDT meetings. Although MDT meetings are valuable practices to optimize treatment or management options for patients, its settings might be subject to difficulties to federate the appropriate-number of participants as well as cost-effectiveness issues. This survey thus suggests the need of a standardized process of MDT meetings while taking account specificities of oncogenetics. Copyright © 2016 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Resolution of a Rank-Deficient Adjustment Model Via an Isomorphic Geometrical Setup with Tensor Structure.

DTIC Science & Technology

1987-03-01

would be transcribed as L =AX - V where L, X, and V are the vectors of constant terms, parametric corrections , and b_o bresiduals, respectively. The...tensor. a Just as du’ represents the parametric corrections in tensor notations, the necessary associated metric tensor a’ corresponds to the variance...observations, n residuals, and 0 n- parametric corrections to X (an initial set of parameters), respectively. b 0 b The vctor L is formed as 1. L where

Magnetic field structure in single late-type giants: the effectively single giant V390 Aurigae

NASA Astrophysics Data System (ADS)

Konstantinova-Antova, R.; Aurière, M.; Petit, P.; Charbonnel, C.; Tsvetkova, S.; Lèbre, A.; Bogdanovski, R.

2012-05-01

Aims: We have studied the active giant V390 Aur using spectropolarimetry to obtain direct and simultaneous measurements of the magnetic field and the activity indicators to obtain a precise insight of its activity. Methods: We used the spectropolarimeter NARVAL at the Bernard Lyot Telescope (Observatoire du Pic du Midi, France) to obtain a series of Stokes I and Stokes V profiles. Using the least-squares deconvolution (LSD) technique we were able to detect the Zeeman signature of the magnetic field in each of our 13 observations and to measure its longitudinal component. Using the wide wavelength range of the spectra we were able to monitor the CaII K&H and IR triplet, as well as the Hα lines, which are activity indicators. To reconstruct the magnetic field geometry of V390 Aur on the basis of modelling the Stokes V profiles, we applied the Zeeman Doppler imaging (ZDI) inversion method and present a map for the magnetic field. Based on the obtained spectra, we also refined the fundamental parameters of the star and the Li abundance using MARCS model atmospheres. Results: The ZDI revealed a structure in the radial magnetic field consisting of a polar magnetic spot of positive polarity and several negative spots at lower latitude. A high latitude belt is present on the azimuthal field map, indicative of a toroidal field close to the surface. Similar features are observed in some RS CVn and FK Com -type stars. It was found that the photometric period cannot fit the behaviour of the activity indicators formed in the chromosphere. Their behaviour suggests slower rotation compared to the photosphere, but our dataset is too short for us to be able to estimate their exact periods. All these results can be explained in terms of an α - ω dynamo operation, taking into account the stellar structure and rotation properties of V390 Aur that we studied with up-to-date stellar models computed at solar metallicity with the code STAREVOL. The calculated Rossby number also points to a very efficient dynamo. Based on data obtained using the Bernard Lyot Telescope at Observatoire du Pic du Midi, CNRS and Université Paul Sabatier, France.

Comparison of fractionation methods for nitrogen and starch in maize and grass silages.

PubMed

Ali, M; de Jonge, L H; Cone, J W; van Duinkerken, G; Blok, M C; Bruinenberg, M H; Hendriks, W H

2016-06-01

In in situ nylon bag technique, many feed evaluation systems use a washing machine method (WMM) to determine the washout (W) fraction and to wash the rumen incubated nylon bags. As this method has some disadvantages, an alternate modified method (MM) was recently introduced. The aim of this study was to determine and compare the W and non-washout (D+U) fractions of nitrogen (N) and/or starch of maize and grass silages, using the WMM and the MM. Ninety-nine maize silage and 99 grass silage samples were selected with a broad range in chemical composition. The results showed a large range in the W, soluble (S) and D+U fractions of N of maize and grass silages and the W, insoluble washout (W-S) and D+U fractions of starch of maize silages, determined by both methods, due to variation in their chemical composition. The values for N fractions of maize and grass silages obtained with both methods were found different (p < 0.001). Large differences (p < 0.001) were found in the D+U fraction of starch of maize silages which might be due to different methodological approaches, such as different rinsing procedures (washing vs. shaking), duration of rinsing (40 min vs. 60 min) and different solvents (water vs. buffer solution). The large differences (p < 0.001) in the W-S and D+U fractions of starch determined with both methods can led to different predicted values for the effective rumen starch degradability. In conclusion, the MM with one recommended shaking procedure, performed under identical and controlled experimental conditions, can give more reliable results compared to the WMM, using different washing programs and procedures. Journal of Animal Physiology and Animal Nutrition © 2015 Blackwell Verlag GmbH.

"Cirque du Freak."

ERIC Educational Resources Information Center

Rivett, Miriam

2002-01-01

Considers the marketing strategies that underpin the success of the "Cirque du Freak" series. Describes how "Cirque du Freak" is an account of events in the life of schoolboy Darren Shan. Notes that it is another reworking of the vampire narrative, a sub-genre of horror writing that has proved highly popular with both adult and…

27 CFR 12.31 - List of approved names by country.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., Chateau Yquem, Chateauneuf-du-Pape, Chenas, Chevalier-Montrachet, Chiroubles, Clos de la Roche, Clos de Vougeot, Corton, Corton-Charlemagne, Cote de Beaune, Cote de Beaune-Villages, Cote de Brouilly, Cote de Nuits, Cote de Nuits-Villages, Cote Rotie, Coteaux du Layon, Cotes du Rhone, Echezeaux, Entre-Deux-Mers...

27 CFR 12.31 - List of approved names by country.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., Chateau Yquem, Chateauneuf-du-Pape, Chenas, Chevalier-Montrachet, Chiroubles, Clos de la Roche, Clos de Vougeot, Corton, Corton-Charlemagne, Cote de Beaune, Cote de Beaune-Villages, Cote de Brouilly, Cote de Nuits, Cote de Nuits-Villages, Cote Rotie, Coteaux du Layon, Cotes du Rhone, Echezeaux, Entre-Deux-Mers...

Meeting DG's

ScienceCinema

None

2017-12-09

Le DG J.Adams commente les 3 thèmes de la réunion: 1.) le prochain DG du Cern (qui sera H.Schopper) 2.) le LEP 3.) les conclusions du comité des finances concernant salaires, allocations etc. Discussion entre le DG J.Adams, Mons.Ullmann, chef du personel et l'auditoire

Brain stem hypoplasia associated with Cri-du-Chat syndrome.

PubMed

Hong, Jin Ho; Lee, Ha Young; Lim, Myung Kwan; Kim, Mi Young; Kang, Young Hye; Lee, Kyung Hee; Cho, Soon Gu

2013-01-01

Cri-du-Chat syndrome, also called the 5p-syndrome, is a rare genetic abnormality, and only few cases have been reported on its brain MRI findings. We describe the magnetic resonance imaging findings of a 1-year-old girl with Cri-du-Chat syndrome who showed brain stem hypoplasia, particularly in the pons, with normal cerebellum and diffuse hypoplasia of the cerebral hemispheres. We suggest that Cri-du-Chat syndrome chould be suspected in children with brain stem hypoplasia, particularly for those with high-pitched cries.

Managed Readiness Simulator (MARS) V2: Implementation of the Managed Readiness Model

DTIC Science & Technology

2010-12-01

mesure de répondre aux besoins propres à un ensemble de tâches opérationnelles. La première version du programme MARS (V1) a...mise en œuvre du modèle de gestion de la disponibilité opérationnelle du MARS V2 dans la nouvelle architecture logicielle. La public cible de ce...l’établissement. Le but de la présente étude est de documenter la mise en œuvre du modèle de

Critical Energy Infrastructure Protection in Canada

DTIC Science & Technology

2010-12-01

la participation volontaire du secteur privé dans le système intégré proposé et sur des mesures visant à encourager...que le gouvernement attache beaucoup d’importance à la protection des infrastructures énergétiques essentielles. Neuf ans après les attaques du 11...producteurs d’énergie et des services énergétiques qui sont si essentiels à la prospérité et au bien-être du Canada ainsi qu’à la sécurité de l’Amérique du

Ceremony 25th birthday Cern

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2006-05-08

Célébration du 25ème anniversaire du Cern (jour par jour) avec discours de L.Van Hove et J.B.Adams, des interludes musicals offerts par Mme Mey et ses collègues (au debut 1.mouvement du quatuor avec piano no 3 de L.van Beethoven) Les directeurs généraux procéderont à la remise du souvenir aux membres de personnel ayant 25 années de service dans l'organisation. Un témoignage de reconnaissance est auss fait à l'interprète Mme Zwerner

Capability Challenges in the Human Domain for Intelligence Analysis: Report on Community-Wide Discussions with Canadian Intelligence Professionals

DTIC Science & Technology

2012-03-01

renseignement au cours de l’AF 2012-2013. Cette enquête examinera plus en profondeur les problèmes humains dans la production du renseignement afin...the Queen in Right of Canada, as represented by the Minister of National Defence, 2011 © Sa Majesté la Reine ( en droit du Canada), telle que...ensemble. L’étude a également analysé de quelle façon la recherche en science du comportement peut aider la collectivité du renseignement à aborder

2010 Coalition Battle Management Language Workshop (Atelier 2010 sur le langage de gestion du champ de bataille pour les operations en coalition)

DTIC Science & Technology

2010-02-01

Feb 2010 2010 Coalition Battle Management Language Workshop (Atelier 2010 sur le langage de gestion du champ de bataille pour les opérations en...RTO MEETING PROCEEDINGS MP-MSG-079 2010 Coalition Battle Management Language Workshop (Atelier 2010 sur le langage de gestion du champ de ...RTO-MP-MSG-079 ES - 3 Atelier 2010 sur le langage de gestion du champ de bataille pour les opérations en coalition (RTO-MP-MSG-079

Monogamy inequalities for the Einstein-Podolsky-Rosen paradox and quantum steering

NASA Astrophysics Data System (ADS)

Reid, M. D.

2013-12-01

Monogamy inequalities for the way bipartite Einstein-Podolsky-Rosen (EPR) steering can be distributed among N systems are derived. One set of inequalities is based on witnesses with two measurement settings, and may be used to demonstrate correlation of outcomes between two parties, that cannot be shared with more parties. It is shown that the monogamy for steering is directional. Two parties cannot independently demonstrate steering of a third system, using the same two-setting steering witness, but it is possible for one party to steer two independent systems. This result explains the monogamy of two-setting Bell inequality violations and the sensitivity of the continuous variable (CV) EPR criterion to losses on the steering party. We generalize to m settings. A second type of monogamy relation gives the quantitative amount of sharing possible, when the number of parties is less than or equal to m, and takes a form similar to the Coffman-Kundu-Wootters relation for entanglement. The results enable characterization of the tripartite steering for CV Gaussian systems and qubit Greenberger-Horne-Zeilinger and W states.

Remediation of soils contaminated with particulate depleted uranium by multi stage chemical extraction.

PubMed

Crean, Daniel E; Livens, Francis R; Sajih, Mustafa; Stennett, Martin C; Grolimund, Daniel; Borca, Camelia N; Hyatt, Neil C

2013-12-15

Contamination of soils with depleted uranium (DU) from munitions firing occurs in conflict zones and at test firing sites. This study reports the development of a chemical extraction methodology for remediation of soils contaminated with particulate DU. Uranium phases in soils from two sites at a UK firing range, MOD Eskmeals, were characterised by electron microscopy and sequential extraction. Uranium rich particles with characteristic spherical morphologies were observed in soils, consistent with other instances of DU munitions contamination. Batch extraction efficiencies for aqueous ammonium bicarbonate (42-50% total DU extracted), citric acid (30-42% total DU) and sulphuric acid (13-19% total DU) were evaluated. Characterisation of residues from bicarbonate-treated soils by synchrotron microfocus X-ray diffraction and X-ray absorption spectroscopy revealed partially leached U(IV)-oxide particles and some secondary uranyl-carbonate phases. Based on these data, a multi-stage extraction scheme was developed utilising leaching in ammonium bicarbonate followed by citric acid to dissolve secondary carbonate species. Site specific U extraction was improved to 68-87% total U by the application of this methodology, potentially providing a route to efficient DU decontamination using low cost, environmentally compatible reagents. Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.

Seven Strategies for Improving the Quality and Efficiency of the Education System. Notes, Comments... No. 192 = Sept strategies visant a ameliorer la qualite et l'efficacite du systeme d'education.

ERIC Educational Resources Information Center

Schiefelbein, Ernesto

Seven strategies for improving the quality and efficiency of educational system in Latin American are delineated within the context of background information on the coverage and efficiency of school systems from 1970 to 1980, technical and institutional limitations to educational progress, and an estimate of the impact of the strategies.…

Information non précise sur la taille du pénis en République Démocratique du Congo: à propos de 21 sources

PubMed Central

Mulenga, Philippe Cilundika; Kazadi, Alex Bukasa

2016-01-01

Introduction La taille du pénis constitue une préoccupation de beaucoup des gens actuellement et certains ne sont pas satisfaits de la dimension de leur pénis comme le montre l’étude de Tiggemann en 2008. Il existe relativement peu d'études sur le pénis en érection. Cela peut refléter les tabous culturels des chercheurs ou des médecins en interaction avec les hommes qui sont dans un état d’excitation sexuelle. Toutes fois, il est important pour les personnes qui annoncent des détails sur la taille du pénis d’annoncer d’abord les repères de la mesure du pénis puis ensuite donner les chiffres que proposent les chercheurs. Méthodes Notre enquête de type descriptif transversale s’est effectuée dans les deux grandes villes de la République Démocratique du Congo à savoir la ville de Kinshasa et la ville de Lubumbashi, pendant une période de deux ans soit de Mai 2014 à Mai 2016. Au total, 21 sources d’information ont constitué notre échantillon dont 8 à Kinshasa et 13 à Lubumbashi et nous avons trouvé cela suffisant car les sujets à caractère sexuel sont souvent rares chez nous. Les paramètres étudiés étaient: la nature de la source, la précision de la technique de la mesure, la présence de référence bibliographique, la longueur annoncée du pénis. Résultats La majorité des sources d’information sont faites des émissions de radio et de télévision (23,8%), ceci pourra s’expliquer par le fait que dans notre milieu il y a de plus en plus des chaines de radio et télévision et surtout dans les grandes villes. Concernant la précision de la technique de la mesure du pénis lors du partage du message sur la taille du pénis, l’étude nous montre que la majorité des sources d’information ne signale pas cela lorsqu’elles annoncent la taille du pénis au public soit 85,7%. Plusieurs sources ne déclarent pas les références bibliographiques (57,1%). Lorsqu’on regarde même les chiffres de la taille du pénis annoncée, l’on voit les proportions majoritaires suivantes: 14 cm comme taille normale soit 28,6%, suivi de ceux là qui disent 15 cm soit 23,8% et de 15 à 20 cm soit 19%. Conclusion Ces résultats sont une interpellation des tous les acteurs responsables de la diffusion de l’information sur la santé sexuelle (taille du pénis): la rigueur scientifique consiste à chercher l’information dans des sources fiables. PMID:28154646

The pilot climate data system

NASA Technical Reports Server (NTRS)

Reph, M. G.; Treinish, L. A.; Smith, P. H.

1984-01-01

The Pilot Climate Data System (PCDS) is an interactive scientific information management system for locating, obtaining, manipulating, and displaying climate-research data. The PCDS was developed to manage a large collection of data of interest to the National Aeronautics and Space Administration's (NASA) research community and currently provides such support for approximately twenty data sets. In order to provide the PCDS capabilities, NASA's Goddard Space Flight Center (NASA/GSFC) has integrated the capabilities of several general-purpose software packages with specialized software for reading and reformatting the supported data sets. These capabilities were integrated in a manner which allows the PCDS to be easily expanded, either to provide support for additional data sets or to provide additional functional capabilities. This also allows the PCDS to take advantage of new technology as it becomes available, since parts of the system can be replaced with more powerful components without significantly affecting the user interface.

MyOcean Central Information System - Achievements and Perspectives

NASA Astrophysics Data System (ADS)

de Dianous, Rémi; Jolibois, Tony; Besnard, Sophie

2015-04-01

MyOcean (http://www.myocean.eu) is providing a pre-operational service, for forecasts, analysis and expertise on ocean currents, temperature, salinity, sea level, primary ecosystems and ice coverage. Since 2009, three successive projects (MyOcean-I, MyOcean-II and MyOcean-Follow-on) have been designed to prepare and to lead the demonstration phases of the future Copernicus Marine Environment Monitoring Service. The main goal of these projects was to build a system of systems offering the users a unique access point to European oceanographic data. Reaching this goal at European level with 59 partners from 28 different countries was a real challenge: initially, each local system had its own human processes and methodology, its own interfaces for production and dissemination. At the end of MyOcean Follow-on, any user can connect to one web portal, browse an interactive catalogue of products and services, use one login to access all data disseminated through harmonized interfaces in a common format and contact a unique centralized service desk. In this organization the central information system plays a key role. The production of observation and forecasting data is done by 48 Production Units (PU). Product download and visualisation are hosted by 26 Dissemination Units (DU). All these products and associated services are gathered in a single system hiding the intricate distributed organization of PUs and DUs. This central system will be presented in detail, including notably the technical choices in architecture and technologies which have been made and why, and the lessons learned during these years of real life of the system, taking into account internal and external feedbacks. Then, perspectives will be presented to sketch the future of such system in the next Marine Copernicus Service which is meant to be fully operational from 2015 onwards.

Prévention de la transmission mère-enfant du VIH/sida au Bénin: le consentement des femmes au dépistage est-il libre et éclairé ?

PubMed Central

Kêdoté, N.M.; Brousselle, A.; Champagne, F.; Laudy, D.

2016-01-01

Résumé Introduction Dans les politiques internationales et nationales sur le VIH/sida, le consentement libre et éclairé est reconnu comme une composante essentielle des programmes de dépistage. Le consentement libre et éclairé implique pour les femmes enceintes d’obtenir des informations sur le programme de prévention de la transmission du VIH de la mère à l’enfant (PTME), de les comprendre et de faire un choix autonome après avoir évalué les risques et avantages. Cependant, aucune évaluation du programme de PTME ne s’est intéressée au consentement. L’objectif de cet article est d’explorer le caractère libre et éclairé du consentement des femmes enceintes quant au dépistage et à leurs motivations à faire le test. Méthode Nous avons utilisé des données récoltées dans le cadre d’une analyse d’implantation du programme de PTME au Bénin. Cette analyse s’appuie sur un devis d’étude de cas multiples incluant six maternités choisies parmi les 56 sites fonctionnels. Spécifiquement pour l’analyse du consentement, nous avons associé les données provenant d’une enquête à celles d’une recherche qualitative. Résultats Hormis trois cas de dépistage à l’insu, le caractère volontaire du consentement au test est respecté sur les sites de PTME. Vingt-neuf cas de refus ont été identifiés. Les raisons les plus souvent évoquées par les femmes enceintes sont la peur du résultat positif et de ses conséquences sur la vie familiale dans 55,2 % des cas et l’attente de l’accord ou du désaccord du mari dans 27,6 % des cas. Si globalement le consentement a été volontaire sur tous les sites, son caractère éclairé est moins probant. PMID:27840660

Trust-Guided Behavior Adaptation Using Case-Based Reasoning

DTIC Science & Technology

2015-08-01

the same behaviors were evaluated in each set. To account for this, the similarity function looks at the overlap between the two sets and ignores...interruptions would reduce the cost of case genera- tion. 6 Related Work Existing approaches for measuring inverse trust differ from our own in that...where a case- based reasoning system considers the reliability of a case’s source, also takes trust into account . Our work also has sim- ilarities

Capstone Depleted Uranium Aerosol Biokinetics, Concentrations, and Doses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guilmette, Raymond A.; Miller, Guthrie; Parkhurst, MaryAnn

2009-02-26

One of the principal goals of the Capstone Depleted Uranium (DU) Aerosol Study was to quantify and characterize DU aerosols generated inside armored vehicles by perforation with a DU penetrator. This study consequently produced a database in which the DU aerosol source terms were specified both physically and chemically for a variety of penetrator-impact geometries and conditions. These source terms were used to calculate radiation doses and uranium concentrations for various scenarios as part of the Capstone DU Human Health Risk Assessment (HHRA). This paper describes the scenario-related biokinetics of uranium, and summarizes intakes, chemical concentrations to the organs, andmore » E(50) and HT(50) for organs and tissues based on exposure scenarios for personnel in vehicles at the time of perforation as well as for first responders. For a given exposure scenario (duration time and breathing rates), the range of DU intakes among the target vehicles and shots was not large, about a factor of 10, with the lowest being from a ventilated operational Abrams tank and the highest being for an unventilated Abrams with DU penetrator perforating DU armor. The ranges of committed effective doses were more scenario-dependent than were intakes. For example, the largest range, a factor of 20, was shown for scenario A, a 1-min exposure, whereas, the range was only a factor of two for the first-responder scenario (E). In general, the committed effective doses were found to be in the tens of mSv. The risks ascribed to these doses are discussed separately.« less

Licochalcone-A Induces Intrinsic and Extrinsic Apoptosis via ERK1/2 and p38 Phosphorylation-mediated TRAIL Expression in Head and Neck Squamous Carcinoma FaDu Cells

PubMed Central

Park, Mi-Ra; Kim, Su-Gwan; Cho, In-A; Oh, Dahye; Kang, Kyeong-Rok; Lee, Sook-Young; Moon, Sung-Min; Cho, Seung Sik; Yoon, Goo; Kim, Chun Sung; Oh, Ji-Su; You, Jae-Seek; Kim, Do Kyung; Seo, Yo-Seob; Im, Hee-Jeong; Kim, Jae-Sung

2015-01-01

We investigated Licochalcone-A (Lico-A)-induced apoptosis and the pathway underlying its activity in a pharyngeal squamous carcinoma FaDu cell line. Lico-A purified from root of Glycyrrhiza inflata had cytotoxic effects, significantly increasing cell death in FaDu cells. Using a cell viability assay, we determined that the IC50 value of Lico-A in FaDu cells was approximately 100 µM. Chromatin condensation was observed in FaDu cells treated with Lico-A for 24 h. Consistent with this finding, the number of apoptotic cells increased in a time-dependent manner when FaDu cells were treated with Lico-A. TRAIL was significantly up-regulated in Lico-A-treated FaDu cells in a dose-dependent manner. Apoptotic factors such as caspases and PARP polymerase were subsequently activated in a caspase-dependent manner. In addition, levels of pro-apoptotic factors increased significantly in response to Lico-A treatment, while levels of anti-apoptotic factors decreased. Lico-A-induced TRAIL expression was mediated in part by a MAPK signaling pathway involving ERK1/2 and p38. Lastly, in an in vivo xenograft mouse model, Lico-A treatment effectively suppressed the growth of FaDu cell xenografts by activating caspase-3, without affecting the body weight of mice. Taken together, these data suggest that Lico-A has potential chemopreventive effects and should therefore be developed as a chemotherapeutic agent for pharyngeal squamous carcinoma. PMID:25572524

Model-dependence of neutrino emissivities and neutrino luminosities of neutron stars from the direct Urca processes and the modified Urca processes

NASA Astrophysics Data System (ADS)

Yin, Peng; Fan, Xiaohua; Dong, Jianmin; Guo, Wenmei; Zuo, Wei

2017-05-01

The neutrino emissivities in β-stable neutron star matter from the direct Urca (DU) processes and the modified Urca (MU) processes have been investigated by adopting 26 Skyrme interactions. Several physical quantities related to the MU processes and the DU processes have been calculated and discussed. The model-dependence of the neutrino emissivities from the DU processes is found to stem mainly from the model-dependence of the effective mass, while the neutrino emissivities from the MU processes are determined by the competition between the effects of the symmetry energy and the effective mass. Besides, we have investigated the total neutrino luminosities of neutron stars, with the masses of 1.2 , 1.4 , 1.6 and 1.8M⊙, from the DU processes and the MU processes. The neutrino luminosity of a neutron star is found to be primarily determined by whether the electron DU process is allowed or not. As long as the electron DU process can occur, the total luminosity turns out to be 5 to 8 orders of magnitude larger as compared with the case that the DU process is forbidden, which indicates that the strongest model-dependence of the neutrino luminosity comes from that of the symmetry energy and the equation of state (EOS) of neutron star matter. In the case that the DU processes are allowed, the discrepancy of the calculated neutrino luminosity using various Skyrme interactions remains noticeable, which is essentially attributed to the model-dependence of the symmetry energy, the EOS of NS matter and the effective masses.

GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fiorentini, Chiara; Bodei, Serena; Bedussi, Francesca

2014-04-15

Non-metastatic glycoprotein melanoma protein B (GPNMB), also known as osteoactivin (OA) is expressed in a wide array of tumors and represents an emerging target for drug development. In this study, we investigated the role of GPNMB/OA in the progression of human metastatic DU145 and PC3 prostate cancer cells. GPNMB/OA contribution in PCa malignant phenotype has been analyzed by small interfering RNA-induced GPNMB/OA silencing. We found that following GPNMB/OA silencing the migration capability of both DU145 and PC3 cells, evaluated by using in vitro invasivity assay, as well as the metalloproteinases MMP-2 and MMP-9 activity were equally strongly inhibited. By contrastmore » knocking down GPNMB/OA weakly attenuated cell proliferation rate of DU145, an effect that paralleled with an increase number of apoptotic cells. However, PC3 cell growth seems to be not affected by GPNMB/OA. Together, these data reveal that GPNMB/OA acts as a critical molecular mediator promoting the acquisition of the more aggressive, pro-metastatic phenotype distinctive of human DU145 and PC3 cell lines. - Highlights: • GPNMB/OA expression correlates with DU145 and PC3 cells malignant phenotype. • GPNMB/OA silencing affects the migration capability of both DU145 and PC3 cells. • GPNMB/OA increases invasiveness by up-regulating MMPs activity. • GPNMB/OA promotes DU145 and PC3 cells progression into a more aggressive phenotype.« less

The Politics of Access to Expensive Drugs: INESSS and the Innovative Pharmaceutical Industry

PubMed Central

Hughes, David

2012-01-01

The innovative pharmaceutical industry employs thousands of people in Quebec and so has the ability to exert strong political pressure; the public statements of Sanofi-Aventis concerning the provincial reimbursement of certain expensive drugs are an example. “Maintaining a dynamic biopharmaceutical industry” is one of four main axes of the drug policy of Quebec's ministry of health. However, this role of government should not take precedence over the efficient and equitable management of health resources. We defend the legitimate and responsible choice of the Institut national d'excellence en santé et en services sociaux du Québec (INESSS) to require an acceptable cost-effectiveness ratio from expensive new drugs. PMID:23634161

La socialisation des jeunes dans les villes du Tiers-Monde — le cas de l'Afrique

NASA Astrophysics Data System (ADS)

Ly, Boubakar

1985-12-01

Third-World cities constitute quasi-laboratories for the study of change and learning. The present article takes the African situation of merging traditional and modern elements as its starting point and analyzes young people's socialization processes in this context. As a consequence of the activities of migrant organizations, the more general circumstances leading to migration and the fact that people are faced with a new `lifestyle' in a complex and often merciless environment, an atmosphere is created where learning for life and vocational training abound with initiative and innovation. This `learning for life' is borne by the informal fabric of new social interactions and the influence of the mass media.

Electrochemical separation of uranium in the molten system LiF-NaF-KF-UF4

NASA Astrophysics Data System (ADS)

Korenko, M.; Straka, M.; Szatmáry, L.; Ambrová, M.; Uhlíř, J.

2013-09-01

This article is focused on the electrochemical investigation (cyclic voltammetry and related studies) of possible reduction of U4+ ions to metal uranium in the molten system LiF-NaF-KF(eut.)-UF4 that can provide basis for the electrochemical extraction of uranium from molten salts. Two-step reduction mechanism for U4+ ions involving one electron exchange in soluble/soluble U4+/U3+ system and three electrons exchange in the second step were found on the nickel working electrode. Both steps were found to be reversible and diffusion controlled. Based on cyclic voltammetry, the diffusion coefficients of uranium ions at 530 °C were found to be D(U4+) = 1.64 × 10-5 cm2 s-1 and D(U3+) 1.76 × 10-5 cm2 s-1. Usage of the nickel spiral electrode for electrorefining of uranium showed fairly good feasibility of its extraction. However some oxidant present during the process of electrorefining caused that the solid deposits contained different uranium species such as UF3, UO2 and K3UO2F5.

Algorithmic network monitoring for a modern water utility: a case study in Jerusalem.

PubMed

Armon, A; Gutner, S; Rosenberg, A; Scolnicov, H

2011-01-01

We report on the design, deployment, and use of TaKaDu, a real-time algorithmic Water Infrastructure Monitoring solution, with a strong focus on water loss reduction and control. TaKaDu is provided as a commercial service to several customers worldwide. It has been in use at HaGihon, the Jerusalem utility, since mid 2009. Water utilities collect considerable real-time data from their networks, e.g. by means of a SCADA system and sensors measuring flow, pressure, and other data. We discuss how an algorithmic statistical solution analyses this wealth of raw data, flexibly using many types of input and picking out and reporting significant events and failures in the network. Of particular interest to most water utilities is the early detection capability for invisible leaks, also a means for preventing large visible bursts. The system also detects sensor and SCADA failures, various water quality issues, DMA boundary breaches, unrecorded or unintended network changes (like a valve or pump state change), and other events, including types unforeseen during system design. We discuss results from use at HaGihon, showing clear operational value.

Three-Level Systems as Amplifiers and Attenuators: A Thermodynamic Analysis

NASA Astrophysics Data System (ADS)

Boukobza, E.; Tannor, D. J.

2007-06-01

Thermodynamics of a three-level maser was studied in the pioneering work of Scovil Schulz-DuBois [Phys. Rev. Lett. 2, 262 (1959)PRLTAO0031-900710.1103/PhysRevLett.2.262]. In this Letter we consider the same three-level model, but we give a full thermodynamic analysis based on Hamiltonian and dissipative Lindblad superoperators. The first law of thermodynamics is obtained using a recently developed alternative [Phys. Rev. A 74, 063823 (2006)PLRAAN1050-294710.1103/PhysRevA.74.063823] to Alicki’s definitions for heat flux and power [J. Phys. AJPHAC50305-4470 12, L103 (1979)10.1088/0305-4470/12/5/007]. Using a novel variation on Spohn’s entropy production function [J. Math. Phys. (N.Y.)JMAPAQ0022-2488 19, 1227 (1978)10.1063/1.523789], we obtain Carnot’s efficiency inequality and the Scovil Schulz-DuBois maser efficiency formula when the three-level system is operated as a heat engine (amplifier). Finally, we show that the three-level system has two other modes of operation—a refrigerator mode and a squanderer mode —both of which attenuate the electric field.

Recent Decline in Extratropical Lower Stratospheric Ozone Attributed to Circulation Changes

NASA Astrophysics Data System (ADS)

Wargan, Krzysztof; Orbe, Clara; Pawson, Steven; Ziemke, Jerald R.; Oman, Luke D.; Olsen, Mark A.; Coy, Lawrence; Emma Knowland, K.

2018-05-01

The 1998-2016 ozone trends in the lower stratosphere are examined using the Modern-Era Retrospective Analysis for Research and Applications Version 2 (MERRA-2) and related National Aeronautics and Space Administration products. After removing biases resulting from step changes in the MERRA-2 ozone observations, a discernible negative trend of -1.67 ± 0.54 Dobson units per decade (DU/decade) is found in the 10-km layer above the tropopause between 20°N and 60°N. A weaker but statistically significant trend of -1.17 ± 0.33 DU/decade exists between 50°S and 20°S. In the Tropics, a positive trend is seen in a 5-km layer above the tropopause. Analysis of an idealized tracer in a model simulation constrained by MERRA-2 meteorological fields provides strong evidence that these trends are driven by enhanced isentropic transport between the tropical (20°S-20°N) and extratropical lower stratosphere in the past two decades. This is the first time that a reanalysis data set has been used to detect and attribute trends in lower stratospheric ozone.

History of Cern

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2007-12-20

Cérémonie à l'occasion de l'apparition du premier volume du livre sur l'histoire du Cern, avec plusieurs personnes présentes qui jouaient un rôle important dans cette organisation européenne couronnée de succès grâce à l'esprit des membres fondateurs qui est et restera essentiel

Locke and Du Bois: Two Major Black Voices Muzzled by Philanthropic Organizations.

ERIC Educational Resources Information Center

Fitchue, M. Anthony

1997-01-01

In 1935, the Howard University philosopher Alain Locke asked W. E. B. Du Bois to contribute to an adult education project for African Americans. Censorship by white-controlled foundations forced Locke to reject the Du Bois essay to protect contributions for causes of great importance to blacks. (Author/SLD)

Reducing Hazardous Emissions at Anniston Army Depot

DTIC Science & Technology

2012-05-01

alkaline detergent DuPont Vertrel SDG Hydrofluorocarbon (HFC)-based immersion vapor degreaser with ultrasonics 3M HFE-72DE Hydrofluoroether (HFE... SDG provided the best results for degreasing (Building 409)  Both systems/products were effective at degreasing the various vehicle components and

Le kyste hydatique du cordon spermatique: une localisation exceptionnelle

PubMed Central

Hamdane, Mohamed Moncef; Bougrine, Fethi; Msakni, Issam; Dhaoui-Ghozzi, Amen; Bouziani, Ammar

2011-01-01

L’ hydatidose est une anthropo-zoonose due au développement chez l'homme de la forme larvaire du taenia Echinococcus granulosis. La plupart des kystes hydatiques se localisent dans le foie et les poumons. Le kyste hydatique du cordon spermatique est extrêmement rare avec seulement 4 cas rapportés dans la littérature. Les auteurs rapportent dans cet article un nouveau cas d'hydatidose du cordon spermatique. Il s'agissait d'un homme de 40 ans qui consultait pour des douleurs scrotales évoluant depuis huit mois. L'examen clinique a mis en évidence une tuméfaction mobile, inguino-scrotale, droite. L’échographie testiculaire a objectivé une hernie inguinale droite associée à deux kystes épididymaires bilatéraux. Le patient a été opéré pour cure de son hernie avec découverte en per-opératoire d'un kyste du cordon spermatique qui a été réséqué. L'examen anatomopathologique a conclu à une hydatidose du cordon spermatique. PMID:22384304

5 CFR 1201.174 - Enforcing the Special Panel decision.

Code of Federal Regulations, 2014 CFR

2014-01-01

.... 1201.174 Section 1201.174 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND... Special Panel, will order the agency concerned to take any action appropriate to carry out the decision of... matter. These regulations are set out in subpart F of this part. ...

5 CFR 1201.174 - Enforcing the Special Panel decision.

Code of Federal Regulations, 2012 CFR

2012-01-01

.... 1201.174 Section 1201.174 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND... Special Panel, will order the agency concerned to take any action appropriate to carry out the decision of... matter. These regulations are set out in subpart F of this part. ...

5 CFR 1201.174 - Enforcing the Special Panel decision.

Code of Federal Regulations, 2011 CFR

2011-01-01

.... 1201.174 Section 1201.174 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND... Special Panel, will order the agency concerned to take any action appropriate to carry out the decision of... matter. These regulations are set out in subpart F of this part. ...

5 CFR 1201.174 - Enforcing the Special Panel decision.

Code of Federal Regulations, 2010 CFR

2010-01-01

.... 1201.174 Section 1201.174 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND... Special Panel, will order the agency concerned to take any action appropriate to carry out the decision of... matter. These regulations are set out in subpart F of this part. ...

Evaluating Teachers of Writing.

ERIC Educational Resources Information Center

Hult, Christine A., Ed.

Describing the various forms evaluation can take, this book delineates problems in evaluating writing faculty and sets the stage for reconsidering the entire process to produce a fair, equitable, and appropriate system. The book discusses evaluation through real-life examples: evaluation of writing faculty by literature faculty, student…

Dedicated Caravan Sites for French Gens du Voyage: Public Health Policy or Construction of Health and Environmental Inequalities?

PubMed

Foisneau, Lise

2017-12-01

In France, gens du voyage ("people who travel" or "travellers") is a term used by the government to categorize various itinerant populations, the majority of which are diverse Romani groups. People categorized as gens du voyage are legally required to reside in particular locations called "dedicated caravan sites." Parliamentary debates about these dedicated caravan sites have clarified that one of the objectives of such sites is to help fulfill the gens du voyage 's right to health. However, there is a significant gap between the officially stated goals of such sites and the reality of life within them. This paper draws on research finding that the conditions in most dedicated caravan sites do not conform with the rights of gens du voyage to acceptable sanitary conditions and other underlying determinants of health.

Dedicated Caravan Sites for French Gens du Voyage

PubMed Central

2017-01-01

Abstract In France, gens du voyage (“people who travel” or “travellers”) is a term used by the government to categorize various itinerant populations, the majority of which are diverse Romani groups. People categorized as gens du voyage are legally required to reside in particular locations called “dedicated caravan sites.” Parliamentary debates about these dedicated caravan sites have clarified that one of the objectives of such sites is to help fulfill the gens du voyage’s right to health. However, there is a significant gap between the officially stated goals of such sites and the reality of life within them. This paper draws on research finding that the conditions in most dedicated caravan sites do not conform with the rights of gens du voyage to acceptable sanitary conditions and other underlying determinants of health. PMID:29302165

Nouvelle methode d'optimisation du cout d'un vol par l'utilisation d'un systeme de gestion de vol et sa validation sur un avion Lockheed L-1011 TriStar

NASA Astrophysics Data System (ADS)

Gagne, Jocelyn

Usually, flights optimization and planning will take place before flight, on ground. However, it is not always feasible to do such optimization, or sometime unpredictable events may force pilots to change the flight path. In those circumstances, the pilots can only rely on charts or their Flight Management System (FMS) in order to maintain an economic flight. However, those FMS often rely on those same charts, which will not take into consideration different parameters, such as the cost index, the length on the flight or the weather. Even if some FMS take into consideration the weather, they may only rely on manually entered or limited data that could be outdated, insufficient or incomplete. The alleviate these problems, the function program's that was developed is mainly to determine the optimum flight profile for an aircraft, or more precisely, at the lowest overall cost, considering a take-off weight and weather conditions. The total cost is based on the value of time as well as the cost of fuel, resulting in the use of a ratio called the cost index. This index allows both to prioritize either the time or fuel consumption according to the costs related to a specific flight and/or airline. Thus, from a weight, the weather (wind, temperature, pressure), and the cost index, the program will calculate from the "Performance DataBase" (PDB) of a specific airplane an optimal flight profile over a given distance. The algorithm is based on linear interpolations in the performances tables using the Lagrange method. Moreover, in order to fully optimize the flight, the current program can, according to departure date and coordinates, download the latest available forecast from environment Canada website and calculate the optimum flight accordingly. The forecast data use by the program take the form of a 0.6 × 0.6 degrees grid in which the effects of wind, pressure and temperature are interpolated according to the aircraft geographical position and time. Using these tables, performances and forecasts, the program is therefore able to calculate the optimum profile from ground, but also in flight, if any change would occur on the path. Because all data is tabulated and not calculated, the required calculation power remains low, resulting in a short calculation time. Keywords: optimization, algorithm, simulation, cost.

Physicochemical characterization of Capstone depleted uranium aerosols III: morphologic and chemical oxide analyses.

PubMed

Krupka, Kenneth M; Parkhurst, Mary Ann; Gold, Kenneth; Arey, Bruce W; Jenson, Evan D; Guilmette, Raymond A

2009-03-01

The impact of depleted uranium (DU) penetrators against an armored target causes erosion and fragmentation of the penetrators, the extent of which is dependent on the thickness and material composition of the target. Vigorous oxidation of the DU particles and fragments creates an aerosol of DU oxide particles and DU particle agglomerations combined with target materials. Aerosols from the Capstone DU aerosol study, in which vehicles were perforated by DU penetrators, were evaluated for their oxidation states using x-ray diffraction (XRD), and particle morphologies were examined using scanning electron microscopy/energy dispersive spectroscopy (SEM/EDS). The oxidation state of a DU aerosol is important as it offers a clue to its solubility in lung fluids. The XRD analysis showed that the aerosols evaluated were a combination primarily of U3O8 (insoluble) and UO3 (relatively more soluble) phases, though intermediate phases resembling U4O9 and other oxides were prominent in some samples. Analysis of particle residues in the micrometer-size range by SEM/EDS provided microstructural information such as phase composition and distribution, fracture morphology, size distribution, and material homogeneity. Observations from SEM analysis show a wide variability in the shapes of the DU particles. Some of the larger particles were spherical, occasionally with dendritic or lobed surface structures. Others appear to have fractures that perhaps resulted from abrasion and comminution, or shear bands that developed from plastic deformation of the DU material. Amorphous conglomerates containing metals other than uranium were also common, especially with the smallest particle sizes. A few samples seemed to contain small bits of nearly pure uranium metal, which were verified by EDS to have a higher uranium content exceeding that expected for uranium oxides. Results of the XRD and SEM/EDS analyses were used in other studies described in this issue of Health Physics to interpret the results of lung solubility studies and in selecting input parameters for dose assessments.

[Dépistage précoce des retards du développement moteur: Outil de dépistage axé sur la famille].

PubMed

Harris, Susan R

2016-08-01

Décrire le test HINT (Harris Infant Neuromotor Test), un test d'évaluation du développement neuromoteur chez les nourrissons publié en 2010, qui s'appuie sur les normes canadiennes et peut être utilisé pour dépister les retards du développement moteur durant la première année de la vie. QUALITÉ DES DONNÉES: D'abondantes recherches ont été publiées sur la fiabilité intra-évaluateur, inter-évaluateur et test-retest ainsi que sur la validité convergente, prédictive, du contenu et des groupes connus du test HINT, de même que sur la sensibilité, la spécificité et les valeurs prédictives négatives et positives des inquiétudes des parents, telles qu'évaluées par le test HINT. La plupart des données probantes sont de niveau II. Il est important de diagnostiquer les retards du développement moteur durant la première année de vie, car ils sont souvent le signe de retards du développement généralisés ou de déficiences précises, telles que la paralysie cérébrale. Les inquiétudes des parents quant au développement moteur de leur enfant sont une valeur prédictive robuste de diagnostics subséquents de retard du développement moteur. Seul le dépistage précoce des retards du développement moteur, initialement par l'entremise d'outils de dépistage comme le test HINT, permet de recommander le patient à une intervention précoce qui profiterait tant à l'enfant qu'à sa famille. Copyright© the College of Family Physicians of Canada.

Differential Efficacy of Combined Therapy With Radiation and AEE788 in High and Low EGFR-Expressing Androgen-Independent Prostate Tumor Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huamani, Jessica; Willey, Christopher; Thotala, Dinesh

2008-05-01

Purpose: To determine the efficacy of combining radiation (XRT) with a dual epidermal growth factor receptor (EGFR)/vascular endothelial growth factor receptor inhibitor, AEE788, in prostate cancer models with different levels of EGFR expression. Methods and Materials: Immunoblotting was performed for EGFR, phosphorylated-EGFR, and phosphorylated-AKT in prostate cancer cells. Clonogenic assays were performed on DU145, PC-3, and human umbilical vein endothelial cells treated with XRT {+-} AEE788. Tumor xenografts were established for DU145 and PC-3 on hind limbs of athymic nude mice assigned to four treatment groups: (1) control, (2) AEE788, (3) XRT, and (4) AEE788 + XRT. Tumor blood flowmore » and growth measurements were performed using immunohistochemistry and imaging. Results: AEE788 effectively decreased phosphorylated-EGFR and phosphorylated-AKT levels in DU145 and PC-3 cells. Clonogenic assays showed no radiosensitization for DU145 and PC-3 colonies treated with AEE788 + XRT. However, AEE788 caused decreased proliferation in DU145 cells. AEE788 showed a radiosensitization effect in human umbilical vein endothelial cells and increased apoptosis susceptibility. Concurrent AEE788 + XRT compared with either alone led to significant tumor growth delay in DU145 tumors. Conversely, PC-3 tumors derived no added benefit from combined-modality therapy. In DU145 tumors, a significant decrease in tumor blood flow with combination therapy was shown by using power Doppler sonography and tumor blood vessel destruction on immunohistochemistry. Maldi-spectrometry (MS) imaging showed that AEE788 is bioavailable and heterogeneously distributed in DU145 tumors undergoing therapy. Conclusions: AEE788 + XRT showed efficacy in vitro/in vivo with DU145-based cell models, whereas PC-3-based models were adequately treated with XRT alone without added benefit from combination therapy. These findings correlated with differences in EGFR expression and showed effects on both tumor cell proliferation and vascular destruction.« less

World heritage site - Bien du Patrimoine Mondial - Kluane/Wrangell-St. Elias/Glacier Bay/Tatshenshini-Alsek

USGS Publications Warehouse

Labay, Keith A.; Wilson, Frederic H.

2004-01-01

The four parks depicted on this map make up a single World Heritage Site that covers 24.3 million acres. Together, they comprise the largest internationally protected land-based ecosystem on the planet. The United Nations Educational, Scientific and Cultural Organization (UNESCO) established the World Heritage Program in 1972 for the identification and protection of the world?s irreplaceable natural and cultural resources. World Heritage Sites are important as storehouses of memory and evolution, as anchors for sustainable tourism and community, and as laboratories for the study and understanding of the earth and culture. This World Heritage Site protects the prominent mountain ranges of Kluane, Wrangell, Saint Elias, and Chugach. It includes many of the tallest peaks on the continent, the world's largest non-polar icefield, extensive glaciers, vital watersheds, and expanses of dramatic wilderness. [Les quatre parcs figurant sur cette carte ne constituent qu?un seul site du patrimoine mondial recouvrant plus de 99 millions de km2, ce qui en fait le plus grand ecosysteme terrestre protege par loi internationale. En 1972, L?UNESCO (l?organisation des Nations Unies pour les sciences, l'education et la culture) a etabli le programme du patrimoine mondial afin d?identifier et de proteger les ressources naturelles et culturelles irremplacables de notre plan?te. Si les sites du patrimoine mondial sont si importants c'est parce qu'ils representent a la fois des livres ouverts sur l?histoire de la Terre, le point de depart du tourisme durable et du developpement des collectivites, des laboratoires pour etudier et comprendre la nature et la culture. Ce site du patrimoine mondial assure la protection des chaines de montagnes de Kluane, Wrangell, Saint Elias, et Chugach. On y trouve plusieurs des plus hauts sommets du continent, le plus grand champ de glace non-polaire du monde, d?immenses glaciers, des bassins hydrologiques essentiels, et de la nature sauvage a perte de vue.

Dépistage précoce des retards du développement moteur

PubMed Central

Harris, Susan R.

2016-01-01

Résumé Objectif Décrire le test HINT (Harris Infant Neuromotor Test), un test d’évaluation du développement neuromoteur chez les nourrissons publié en 2010, qui s’appuie sur les normes canadiennes et peut être utilisé pour dépister les retards du développement moteur durant la première année de la vie. Qualité des données D’abondantes recherches ont été publiées sur la fiabilité intra-évaluateur, inter-évaluateur et test-retest ainsi que sur la validité convergente, prédictive, du contenu et des groupes connus du test HINT, de même que sur la sensibilité, la spécificité et les valeurs prédictives négatives et positives des inquiétudes des parents, telles qu’évaluées par le test HINT. La plupart des données probantes sont de niveau II. Message principal Il est important de diagnostiquer les retards du développement moteur durant la première année de vie, car ils sont souvent le signe de retards du développement généralisés ou de déficiences précises, telles que la paralysie cérébrale. Les inquiétudes des parents quant au développement moteur de leur enfant sont une valeur prédictive robuste de diagnostics subséquents de retard du développement moteur. Conclusion Seul le dépistage précoce des retards du développement moteur, initialement par l’entremise d’outils de dépistage comme le test HINT, permet de recommander le patient à une intervention précoce qui profiterait tant à l’enfant qu’à sa famille. PMID:27521405

Les masques trompeurs de la bipolarité: étude de 100 cas

PubMed Central

Nabih, Fadoua Oueriagli; Benali, Abdesslam; Adali, Imane; Manoudi, Fatiha; Asri, Fatima

2015-01-01

Le trouble bipolaire (TB) est une pathologie dont la prévalence est estimée à 1-2%. Le diagnostic précoce du trouble constitue un enjeu thérapeutique majeur. L'objectif de ce travail est de déterminer les différents diagnostiques attribués aux patients bipolaires avant de recevoir le diagnostic adéquat et de préciser le délai moyen du retard diagnostique. C'est une étude descriptive transversale portant sur 100 patients atteints de TB, inclus selon les critères du DSM V, qui ont été vus en consultation ou bien hospitalisés dans le service de psychiatrie de l'hôpital Militaire Avicenne de Marrakech, durant une période de deux ans. L’âge moyen des patients était de 29,5 ans avec une prédominance masculine (80%). 40% de nos patients ont reçu au début un autre diagnostic que celui du TB et le premier diagnostic retenu était celui de l’épisode dépressif majeur dans 36% des cas, suivi de l'accès psychotique aigu dans 28% des cas, la schizophrénie dans 16,8% et le trouble de personnalité dans 10,2%. Le délai moyen du retard diagnostic était de 64 mois. 50% des patients ayant reçu un autre diagnostic avaient consulté au moins un psychiatre et 60% des patients avaient été hospitalisés au moins une fois avant le diagnostic du TB. Les errances diagnostiques du TB sont bien établies, conduisant forcément à un retard de prise en charge adéquate. Ces données devraient alerter les psychiatres pour favoriser un meilleur dépistage de la manie et de l'hypomanie qui restent les éléments clé du diagnostic du TB. PMID:26587161

Scheduling quality of precise form sets which consist of tasks of circular type in GRID systems

NASA Astrophysics Data System (ADS)

Saak, A. E.; Kureichik, V. V.; Kravchenko, Y. A.

2018-05-01

Users’ demand in computer power and rise of technology favour the arrival of Grid systems. The quality of Grid systems’ performance depends on computer and time resources scheduling. Grid systems with a centralized structure of the scheduling system and user’s task are modeled by resource quadrant and re-source rectangle accordingly. A Non-Euclidean heuristic measure, which takes into consideration both the area and the form of an occupied resource region, is used to estimate scheduling quality of heuristic algorithms. The authors use sets, which are induced by the elements of square squaring, as an example of studying the adapt-ability of a level polynomial algorithm with an excess and the one with minimal deviation.

Toward Active Control of Noise from Hot Supersonic Jets

DTIC Science & Technology

2012-11-15

Instruments PXIe (PCI extensions for Instrumentation-express) system. The PXIe system has four PXIe-4331 cards (8 channels, 24 bits of resolution...üiüj) _ dxjdx ■j \\ düi düj dxj dxi düi du dii dx ?)■ (7) Our intention is to use (7) as an indicator of sound production in high speed

CHEMICAL EFFECTS IN BIOLOGICAL SYSTEMS – DATA DICTIONARY (CEBS-DD): A COMPENDIUM OF TERMS FOR THE CAPTURE AND INTEGRATION OF BIOLOGICAL STUDY DESIGN DESCRIPTION, CONVENTIONAL PHENOTYPES AND ‘OMICS’ DATA

EPA Science Inventory

A critical component in the design of the Chemical Effects in Biological Systems (CEBS) Knowledgebase is a strategy to capture toxicogenomics study protocols and the toxicity endpoint data (clinical pathology and histopathology). A Study is generally an experiment carried out du...

Resilience of Critical Infrastructure to Extreme Fires - Gaps and Challenges

DTIC Science & Technology

2014-04-01

du Canada), telle que représentée par le ministre de la Défense nationale, 2014 3 Abstract …….. This report provides the results of the study...the results of the two fire tests. Résumé …..... Le présent rapport fournit les résultats de l’étude menée par le Conseil national de recherches du...d’entreposage de carburants ou de véhicule-citerne. L’effondrement des tours du World Trade Centre, le 11 septembre 2001, et celui de l’échangeur du pont

DRDC Toronto Technical Stream Integrated Capabilities and Vision

DTIC Science & Technology

2011-09-01

du RT, et les présenter à la séance d’information 2010 destinée à tout le personnel, puis à la réunion du Comité de gestion . Reposant sur une...profession technique, c) adoption d’une culture de collaboration et de réseautage, d ) élargissement de l’influence de la profession technique. Grâce à...d’information 2010 destinée à tout le personnel, puis à la réunion du Comité de gestion . Résultats : Une équipe de projet, composée de huit membres du

Localisation inhabituelle de la tuberculose: ostéoarthrite tuberculose du pouce

PubMed Central

Mortaji, Aziz; Koulali, Khalid; Galuia, Farid

2014-01-01

L'ostéoarthrite tuberculose est rare au niveau des doigts. Nous rapportons une observation d'atteinte du pouce chez un patient de 55 ans. Il avait présenté une tuméfaction douloureuse du pouce droit suite à un traumatisme du pouce. L’étude bactériologique et une biopsie avaient permis de confirmer le diagnostic. Un traitement antibacillaire de 12 mois avait donné des résultats satisfaisants. Les particularités de la prise en charge sont discutées par rapport aux données de la littérature. PMID:25932075

Hyperproduction of alpha-toxin by Staphylococcus aureus results in paradoxically reduced virulence in experimental endocarditis: a host defense role for platelet microbicidal proteins.

PubMed Central

Bayer, A S; Ramos, M D; Menzies, B E; Yeaman, M R; Shen, A J; Cheung, A L

1997-01-01

Staphylococcal alpha-toxin targets several cell types which are important components of cardiac vegetations in endocarditis, including platelets, erythrocytes, and endothelial cells. We evaluated the in vivo role of Staphylococcus aureus alpha-toxin in experimental endocarditis by using isogenic strains differing in the capacity to produce functional alpha-toxin, including 8325-4 (wild-type strain), DU-1090 (a mutant strain with allelic replacement of the alpha-toxin gene [hla]), DU1090(pH35L) (a mutant strain producing a target cell-binding but nonlytic toxin), DU1090(pDU1212) (a variant of DU1090 carrying the cloned hla gene on a multicopy plasmid), and DU1090(pCL84::hla) (a variant of DU1090 with a single copy of the hla gene cloned into the chromosomal lipase locus). In vitro, wild-type alpha-toxin (from parental strain 8325-4) extensively lysed both erythrocytes and platelets. In contrast, mutant alpha-toxin [from strain DU1090(pH35L)] lysed neither cell type. Following exposure to the wild-type alpha-toxin, platelet lysates were found to contain microbicidal activity against Bacillus subtilis (but not against Micrococcus luteus), as well as against the parental and alpha-toxin variant S. aureus strains noted above. Furthermore, lysate microbicidal activity was heat stable, neutralized by polyanionic filters or compounds, and recoverable from anionic filter membranes by hypertonic saline elution. These characteristics are consistent with those of cationic platelet microbicidal proteins (PMPs). Reverse-phase high-pressure liquid chromatography and polyacrylamide gel electrophoresis confirmed the presence of three distinct PMPs (1, 2, and 3) in platelet lysates. In experimental endocarditis, the two variant staphylococcal strains producing either minimal alpha-toxin or nonlytic alpha-toxin in vitro [strains DU1090 and DU1090(pH35L), respectively] exhibited significantly lower virulence in vivo than the parental strain (decreased intravegetation staphylococcal densities). Paradoxically, the two variant staphylococcal strains producing alpha-toxin at supraparental levels in vitro [strains DU1090(p1212) and DU1090(pCL84::hla)] also exhibited significantly decreased induction rates and intravegetation staphylococcal densities in experimental endocarditis versus the parental strain. The reduced in vivo virulence of the latter variant staphylococcal strains could not be explained by differences in bacteremic clearance or initial adherence to sterile vegetations (compared to the parental strain). These findings suggest that the reduced virulence exhibited by the variant staphylococcal strains in this model was related to pathogenetic events subsequent to bacterial adherence to the damaged endocardium. Excess intravegetation secretion of alpha-toxin, leading to increased PMP release (secondary to either increased platelet secretion or lysis), may well explain the reduced virulence observed in experimental endocarditis. PMID:9353046

Evaluating a bilingual patient navigation program for uninsured women with abnormal screening tests for breast and cervical cancer: implications for future navigator research.

PubMed

Simon, Melissa A; Tom, Laura S; Nonzee, Narissa J; Murphy, Kara R; Endress, Richard; Dong, XinQi; Feinglass, Joe

2015-05-01

The DuPage Patient Navigation Collaborative evaluated the Patient Navigation Research Program (PNRP) model for uninsured women receiving free breast or cervical cancer screening through the Illinois Breast and Cervical Cancer Program in DuPage County, Illinois. We used medical records review and patient surveys of 477 women to compare median follow-up times with external Illinois Breast and Cervical Cancer Program and Chicago PNRP benchmarks of performance. We examined the extent to which we mitigated community-defined timeliness risk factors for delayed follow-up, with a focus on Spanish-speaking participants. Median follow-up time (29.0 days for breast and 56.5 days for cervical screening abnormalities) compared favorably to external benchmarks. Spanish-speaking patients had lower health literacy, lower patient activation, and more health care system distrust than did English-speaking patients, but despite the prevalence of timeliness risk factors, we observed no differences in likelihood of delayed (> 60 days) follow-up by language. Our successful replication and scaling of the PNRP navigation model to DuPage County illustrates a promising approach for future navigator research.

Evaluating a Bilingual Patient Navigation Program for Uninsured Women With Abnormal Screening Tests for Breast and Cervical Cancer: Implications for Future Navigator Research

PubMed Central

Tom, Laura S.; Nonzee, Narissa J.; Murphy, Kara R.; Endress, Richard; Dong, XinQi; Feinglass, Joe

2015-01-01

Objectives. The DuPage Patient Navigation Collaborative evaluated the Patient Navigation Research Program (PNRP) model for uninsured women receiving free breast or cervical cancer screening through the Illinois Breast and Cervical Cancer Program in DuPage County, Illinois. Methods. We used medical records review and patient surveys of 477 women to compare median follow-up times with external Illinois Breast and Cervical Cancer Program and Chicago PNRP benchmarks of performance. We examined the extent to which we mitigated community-defined timeliness risk factors for delayed follow-up, with a focus on Spanish-speaking participants. Results. Median follow-up time (29.0 days for breast and 56.5 days for cervical screening abnormalities) compared favorably to external benchmarks. Spanish-speaking patients had lower health literacy, lower patient activation, and more health care system distrust than did English-speaking patients, but despite the prevalence of timeliness risk factors, we observed no differences in likelihood of delayed (> 60 days) follow-up by language. Conclusions. Our successful replication and scaling of the PNRP navigation model to DuPage County illustrates a promising approach for future navigator research. PMID:25713942

A Comparison of different learning models used in Data Mining for Medical Data

NASA Astrophysics Data System (ADS)

Srimani, P. K.; Koti, Manjula Sanjay

2011-12-01

The present study aims at investigating the different Data mining learning models for different medical data sets and to give practical guidelines to select the most appropriate algorithm for a specific medical data set. In practical situations, it is absolutely necessary to take decisions with regard to the appropriate models and parameters for diagnosis and prediction problems. Learning models and algorithms are widely implemented for rule extraction and the prediction of system behavior. In this paper, some of the well-known Machine Learning(ML) systems are investigated for different methods and are tested on five medical data sets. The practical criteria for evaluating different learning models are presented and the potential benefits of the proposed methodology for diagnosis and learning are suggested.

Pelvic fracture urethral injury in males—mechanisms of injury, management options and outcomes

PubMed Central

Barratt, Rachel C.; Bernard, Jason; Mundy, Anthony R.

2018-01-01

Pelvic fracture urethral injury (PFUI) management in male adults and children is controversial. The jury is still out on the best way to manage these injuries in the short and long-term to minimise complications and optimise outcomes. There is also little in the urological literature about pelvic fractures themselves, their causes, grading systems, associated injuries and the mechanism of PFUI. A review of pelvic fracture and male PFUI literature since 1757 was performed to determine pelvic fracture classification, associated injuries and, PFUI classification and management. The outcomes of; suprapubic catheter (SPC) insertion alone, primary open surgical repair (POSR), delayed primary open surgical repair (DPOSR), primary open realignment (POR), primary endoscopic realignment (PER), delayed endoscopic treatment (DET) and delayed urethroplasty (DU) in male adults and children in all major series have been reviewed and collated for rates of restricture (RS), erectile dysfunction (ED) and urinary incontinence (UI). For SPC, POSR, DPOSR, POR, PER, DET and DU; (I) mean RS rate was 97.9%, 53.9%, 18%, 58.3%, 62.0%, 80.2%, 14.4%; (II) mean ED rate was 25.6%, 22.5%, 71%, 37.2%, 23.6%, 31.9%, 12.7%; (III) mean UI rate was 6.7%, 13.6%, 0%, 14.5%, 4.1%, 4.1%, 6.8%; (IV) mean FU in months was 46.3, 29.4, 12, 61, 31.4, 31.8, 54.9. For males with PFUI restricture and new onset ED is lowest following DU whilst UI is lowest following DPOSR. On balance DU offers the best overall outcomes and should be the treatment of choice for PFUI. PMID:29644168

Pelvic fracture urethral injury in males-mechanisms of injury, management options and outcomes.

PubMed

Barratt, Rachel C; Bernard, Jason; Mundy, Anthony R; Greenwell, Tamsin J

2018-03-01

Pelvic fracture urethral injury (PFUI) management in male adults and children is controversial. The jury is still out on the best way to manage these injuries in the short and long-term to minimise complications and optimise outcomes. There is also little in the urological literature about pelvic fractures themselves, their causes, grading systems, associated injuries and the mechanism of PFUI. A review of pelvic fracture and male PFUI literature since 1757 was performed to determine pelvic fracture classification, associated injuries and, PFUI classification and management. The outcomes of; suprapubic catheter (SPC) insertion alone, primary open surgical repair (POSR), delayed primary open surgical repair (DPOSR), primary open realignment (POR), primary endoscopic realignment (PER), delayed endoscopic treatment (DET) and delayed urethroplasty (DU) in male adults and children in all major series have been reviewed and collated for rates of restricture (RS), erectile dysfunction (ED) and urinary incontinence (UI). For SPC, POSR, DPOSR, POR, PER, DET and DU; (I) mean RS rate was 97.9%, 53.9%, 18%, 58.3%, 62.0%, 80.2%, 14.4%; (II) mean ED rate was 25.6%, 22.5%, 71%, 37.2%, 23.6%, 31.9%, 12.7%; (III) mean UI rate was 6.7%, 13.6%, 0%, 14.5%, 4.1%, 4.1%, 6.8%; (IV) mean FU in months was 46.3, 29.4, 12, 61, 31.4, 31.8, 54.9. For males with PFUI restricture and new onset ED is lowest following DU whilst UI is lowest following DPOSR. On balance DU offers the best overall outcomes and should be the treatment of choice for PFUI.

Effects of depleted uranium on survival, growth, and metamorphosis in the african clawed frog (Xenopus laevis)

USGS Publications Warehouse

Mitchell, S.E.; Caldwell, C.A.; Gonzales, G.; Gould, W.R.; Arimoto, R.

2005-01-01

Embryos (stage 8-47, Nieuwkoop and Faber) of the African clawed frog (Xenopus laevis) were subjected to water-borne depleted uranium (DU) concentrations that ranged from 4.8 to 77.7 mg/Lusing an acute 96-h frog embryo teratogenesis assay-Xenopus (FETAX). In a chronic 64-d assay, X. laevis (from embryo through metamorphosis; stages 8-66) were subjected to concentrations of DU that ranged from 6.2 to 54.3 mg/L Our results indicate DU is a non teratogenic metal. No effects on mortality, malformations, or growth were observed in the 96-h FETAX with concentrations of DU that ranged from 4.8 to 77.7 mg/L From stage 8 to stage 47, X. laevis tadpoles do not actively feed and the gills are not well developed. Thus, uptake of DU was reduced despite exposure to elevated concentrations. The 64-d assay resulted in no concentration response for either mortality or malformations; however, a delay in metamorphosis was observed in tadpoles subjected to elevated DU concentrations (from 13.1 to 54.3 mg/L) compared to tadpoles in both the well-water control and reference. The delay in metamorphosis was likely due to increasing body burden of DU that ranged from 0.98 to 2.82 mg/kg. Copyright?? Taylor & Francis Inc.

Identification d'une loi thermo-élasto-viscoplastique en vue de la modélisation du laminage à chaud du cuivre

NASA Astrophysics Data System (ADS)

Moureaux, P.; Moto Mpong, S.; Remy, M.; Bouffioux, C.; Lecomte-Beckers, J.; Habraken, A. M.

2002-12-01

la mise au point d'un modèle de simulation de la dernière passe du laminage à chaud du cuivre ne présente à priori pas de problème du point de vue numérique pour un code d'éléments finis non linéaire. La collecte d'informations précises tant sur le procédé industriel que sur le comportement du matériau est par contre une opération non triviale. Cet article présente les diverses méthodes expérimentales mises en œuvre pour caractériser le matériau : essais de compression à chaud, mesures d'analyse thermique différentielle, essais de dilatométrie et de diffusivité. Les méthodes permettant d'identifier les paramètres de la loi élasto-visco-plastique de type Norton-Hoff à partir des essais sont présentées et une analyse bibliographique investigue le problème de la détermination du module de Young à haute température. Tant les hypothèses supplémentaires relatives au procédé et nécessaires au modèle que les résultats finaux sont résumés.

Potential late health effects of depleted uranium and tungsten used in armor-piercing munitions: comparison of neoplastic transformation and genotoxicity with the known carcinogen nickel.

PubMed

Miller, Alexandra C; Xu, Jiaquan; Stewart, Michael; Prasanna, Pataje G S; Page, Natalie

2002-02-01

Limited data exist to permit an accurate assessment of risks for carcinogenesis and mutagenesis from embedded fragments or inhaled particulates of depleted uranium (DU). Ongoing studies have been designed to provide information about the carcinogenic potential of DU using in vitro and in vivo assessments of morphological transformation as well as cytogenetic, mutagenic, and oncogenic effects. For comparison, we also examined tungsten alloys used in military projectiles and the known carcinogen nickel. Quantitative and qualitative in vitro transformation studies were done to assess the carcinogenic potential of radiation and chemical hazards. Using a human osteosarcoma cell model, we demonstrated that soluble and insoluble DU compounds can transform cells to the tumorigenic phenotype, as characterized by morphological, biochemical, and oncogenic changes consistent with tumor cell behavior. Tungsten alloys and nickel were also shown to be neoplastic transforming agents, although at a frequency less than that of DU. Sister chromatid exchange, micronuclei, and alkaline filter elution assays showed DU and tungsten alloys were genotoxic. Exposure to a nontoxic, nontransforming dose of DU induced a small but statistically significant increase in the number of dicentrics formed in cells. These results suggest that long-term exposure to DU or tungsten alloys could be critical to the development of neoplastic disease in humans and that additional studies are needed.

Le cannabis et les enfants et adolescents canadiens

PubMed Central

Grant, Christina N; Bélanger, Richard E

2017-01-01

Résumé L’usage du cannabis, la drogue illicite la plus consommée dans le monde, est fréquent chez les adolescents canadiens. La consommation de cannabis à l’adolescence peut provoquer des modifications fonctionnelles et structurelles du cerveau en développement et induire une atteinte cérébrale. Dans ce groupe d’âge, la consommation de marijuana s’associe fortement à la dépendance au cannabis et à d’autres troubles de l’usage d’une substance, à l’adoption et au maintien du tabagisme, à l’augmentation des troubles de santé mentale, y compris la dépression, l’anxiété et la psychose, à une perturbation du développement neurologique et à un déclin cognitif ainsi qu’à une diminution de la performance scolaire et des réalisations au cours de la vie. Le taux de soins médicaux aigus et d’hospitalisations chez les jeunes enfants qui ont consommé involontairement du cannabis est en hausse. Compte tenu du débat en cours sur la réglementation du cannabis au Canada, l’examen attentif des preuves de ses effets sur la santé et la mise en place de mécanismes de protection deviennent des priorités absolues en santé publique.

La Base de Donnees ERIC: Evaluation de Son Utilisation et Discussion des Choix du Systeme (The ERIC Database: An Evaluation of Its Use and a Discussion of the System Model).

ERIC Educational Resources Information Center

Malrieu, Denise

1983-01-01

This overview of the ERIC system begins with a brief history of the system; a description of the types and numbers of materials contained in the database; sources of types of information for educators that are not processed by ERIC; and the various publications and reference materials produced by and for the system. The analysis of ERIC usage in…

Hardware Description of Mass Weather Dissemination System Exploratory Engineering Model.

DTIC Science & Technology

1982-09-01

TELCO BARGE-IN TLOSSE LOCAL TELCO BARGE-IN i • TELCO SYSTEM EQUIPMENT NORTH ROUTES TELCO BARGE-IN’ ’ RE-I...34 TELCO SYSTEM EQUIPMENT SOUTH/WEST ROUTES 81- FIGURE 1. FUNCTIONAL DESCRIPTION OF THE TRIAL PATWAS OPERATION 2 f . .... " I’, ." The New York City PATWAS...du ring the test for both the old and improved PATWAS systems , and (3) questionnaire data from four questionnaires, one for an initial appraisal

Association between Fatigue and Autistic Symptoms in Children with Cri du Chat Syndrome

ERIC Educational Resources Information Center

Claro, Anthony; Cornish, Kim; Gruber, Reut

2011-01-01

In the current study, the authors examined whether the fatigue level of children diagnosed with cri du chat syndrome was associated with the expression of autistic symptoms. Sixty-nine children with cri du chat syndrome were compared with 47 children with moderate to severe intellectual disabilities who did not differ on intellectual severity.…

Actes des Journees de linguistique (Proceedings of the Linguistics Conference) (13th, Quebec, Canada, March 25-26, 1999).

ERIC Educational Resources Information Center

Kavanagh, Eric, Ed.

Papers on language research in this volume include the following: Pour une comparaison des voyelles nasals du Quebec et du Haut-Jura: observations, methodologie et outils infomatiques (A Comparison of Quebec and Haut-Jura's Nasal Vowels: Observations, Methodologies, and Instrumentation) (Vincent Arnaud and Claude Paradis); Le negociation du sens…

Prevalence of Autism Spectrum Phenomenology in Cornelia de Lange and Cri du Chat Syndromes

ERIC Educational Resources Information Center

Moss, Joanna F.; Oliver, Chris; Berg, Katy; Kaur, Gurmeash; Jephcott, Lesley; Cornish, Kim

2008-01-01

Autism spectrum disorder characteristics have not been evaluated in Cornelia de Lange and Cri du Chat syndromes using robust assessments. The Autism Diagnostic Observation Schedule and Social Communication Questionnaire were administered to 34 participants with Cornelia de Lange syndrome and a comparison group of 23 participants with Cri du Chat…

Pyrosequencing analysis of bacterial diversity in dental unit waterlines.

PubMed

Costa, Damien; Mercier, Anne; Gravouil, Kevin; Lesobre, Jérôme; Delafont, Vincent; Bousseau, Anne; Verdon, Julien; Imbert, Christine

2015-09-15

Some infections cases due to exposure to output water from dental unit waterlines (DUWL) have been reported in the literature. However, this type of healthcare-associated risk has remained unclear and up until now the overall bacterial composition of DUWL has been poorly documented. In this study, 454 high-throughput pyrosequencing was used to investigate the bacterial community in seven dental offices (N = 7) and to identify potential bacterial pathogenic sequences. Dental unit waters (DUW) were collected from the tap water supplying units (Incoming Water; IW) to the output exposure point of the turbine handpiece (Output water; OW) following a stagnation period (OWS), and immediately after the last patient of the sampling day (OWA). A high bacterial diversity was revealed in DUW with 394 operational taxonomic units detected at the genus level. In addition to the inter-unit variability observed, results showed increased total bacterial cell concentration and shifts in bacterial community composition and abundance at the genus level, mainly within the Gamma- and Alpha-Proteobacteria class, as water circulated in the dental unit (DU). Results showed that 96.7%, 96.8% and 97.4% of the total sequences from IW, OWS and OWA respectively were common to the 3 defined water groups, thereby highlighting a common core microbiome. Results also suggested that stagnation and DU maintenance practices were critical to composition of the bacterial community. The presence of potentially pathogenic genera was detected, including Pseudomonas and Legionella spp. Emerging and opportunistic pathogenic genera such as Mycobacterium, Propionibacterium and Stenotrophomonas were likewise recovered in DUW. For the first time, an exhaustive evaluation of the bacterial communities present in DUW was performed taking into account the circulation of water within the DU. This study highlights an ignored diversity of the DUWL bacterial community. Our findings also contribute to a better appreciation of the potential infectious risk associated with dental care and suggest the importance of better managing microbial quality in DUW. Copyright © 2015 Elsevier Ltd. All rights reserved.

Navigation d'un vehicule autonome autour d'un asteroide

NASA Astrophysics Data System (ADS)

Dionne, Karine

Les missions d'exploration planetaire utilisent des vehicules spatiaux pour acquerir les donnees scientifiques qui font avancer notre connaissance du systeme solaire. Depuis les annees 90, ces missions ciblent non seulement les planetes, mais aussi les corps celestes de plus petite taille comme les asteroides. Ces astres representent un defi particulier du point de vue des systemes de navigation, car leur environnement dynamique est complexe. Une sonde spatiale doit reagir rapidement face aux perturbations gravitationnelles en presence, sans quoi sa securite pourrait etre compromise. Les delais de communication avec la Terre pouvant souvent atteindre plusieurs dizaines de minutes, il est necessaire de developper des logiciels permettant une plus grande autonomie d'operation pour ce type de mission. Ce memoire presente un systeme de navigation autonome qui determine la position et la vitesse d'un satellite en orbite autour d'un asteroide. Il s'agit d'un filtre de Kalman etendu adaptatif a trois degres de liberte. Le systeme propose se base sur l'imagerie optique pour detecter des " points de reperes " qui ont ete prealablement cartographies. Il peut s'agir de crateres, de rochers ou de n'importe quel trait physique discernable a la camera. Les travaux de recherche realises se concentrent sur les techniques d'estimation d'etat propres a la navigation autonome. Ainsi, on suppose l'existence d'un logiciel approprie qui realise les fonctions de traitement d'image. La principale contribution de recherche consiste en l'inclusion, a chaque cycle d'estimation, d'une mesure de distance afin d'ameliorer les performances de navigation. Un estimateur d'etat de type adaptatif est necessaire pour le traitement de ces mesures, car leur precision varie dans le temps en raison de l'erreur de pointage. Les contributions secondaires de recherche sont liees a l'analyse de l'observabilite du systeme ainsi qu'a une analyse de sensibilite pour six parametres principaux de conception. Les resultats de simulation montrent que l'ajout d'une mesure de distance par cycle de mise a jour entraine une amelioration significative des performances de navigation. Ce procede reduit l'erreur d'estimation ainsi que les periodes de non-observabilite en plus de contrer la dilution de precision des mesures. Les analyses de sensibilite confirment quant a elles la contribution des mesures de distance a la diminution globale de l'erreur d'estimation et ce pour une large gamme de parametres de conception. Elles indiquent egalement que l'erreur de cartographie est un parametre critique pour les performances du systeme de navigation developpe. Mots cles : Estimation d'etat, filtre de Kalman adaptatif, navigation optique, lidar, asteroide, simulations numeriques

Fidelity under isospectral perturbations: a random matrix study

NASA Astrophysics Data System (ADS)

Leyvraz, F.; García, A.; Kohler, H.; Seligman, T. H.

2013-07-01

The set of Hamiltonians generated by all unitary transformations from a single Hamiltonian is the largest set of isospectral Hamiltonians we can form. Taking advantage of the fact that the unitary group can be generated from Hermitian matrices we can take the ones generated by the Gaussian unitary ensemble with a small parameter as small perturbations. Similarly, the transformations generated by Hermitian antisymmetric matrices from orthogonal matrices form isospectral transformations among symmetric matrices. Based on this concept we can obtain the fidelity decay of a system that decays under a random isospectral perturbation with well-defined properties regarding time-reversal invariance. If we choose the Hamiltonian itself also from a classical random matrix ensemble, then we obtain solutions in terms of form factors in the limit of large matrices.

Detection de la fin de la compaction des anodes par le son

NASA Astrophysics Data System (ADS)

Sanogo, Bazoumana

L'objectif de ce projet etait de developper un outil de controle en temps reel du temps de compaction en se servant du son genere par le vibrocompacteur pendant le formage des anodes crues. Ainsi, une application a ete developpee pour l'analyse des sons enregistres. Des essais ont ete realises avec differents microphones pour une meilleure qualite des mesures et un a ete choisi pour la suite du projet. De meme, differents tests ont ete realises sur des anodes de laboratoire ainsi que des anodes a l'echelle industrielle afin de mettre en place une methode pour la detection du temps optimal necessaire au formage des anodes. Les travaux au laboratoire de carbone a l'Universite du Quebec a Chicoutimi (UQAC) ont consiste a l'enregistrement de son des anodes fabriquees sur place avec differentes configurations; et a la caracterisation de certaines anodes de l'usine. Les anodes fabriquees au laboratoire sont reparties en deux groupes. Le premier regroupe les anodes pour la validation de notre methode. Ce sont des anodes produites avec des temps de compaction differents. Le laboratoire de carbone a l'UQAC est unique et il est possible de produire des anodes avec les memes proprietes que celles des anodes industrielles. Par consequent, la validation initialement prevue a l'usine a ete effectuee avec les anodes de laboratoire. Le deuxieme groupe a servi a etudier les effets des matieres premieres sur le temps de compaction. Le type de coke et le type de brai ont constitue les differentes variations dans ce deuxieme groupe. Quant aux tests et mesures a l'usine, ils ont ete realises en trois campagnes de mesure. La premiere campagne en juin 2014 a servi a standardiser et a trouver le meilleur positionnement des appareils pour les mesures, a regler le logiciel et a faire les premieres mesures. Une deuxieme campagne en mai 2015 a fait l'objet d'enregistrement de son en classant les anodes selon differents temps de compaction. La troisieme et derniere campagne en decembre 2015 a ete le lieu de tests finaux a l'usine en fabriquant des anodes avec differents criteres (variation du temps de compaction, taux de brai, arret manuel du compacteur, variation de la pression des ballons du haut du compacteur). Ces anodes ont ete ensuite analysees au laboratoire a l'UQAC. En parallele a ces travaux precites, l'amelioration de l'application d'analyse du son a ete faite avec le choix des parametres d'analyse et leur standardisation. Les resultats des premiers tests au laboratoire et ceux de la campagne de juin 2014 ont montre que la formation des anodes se fait suivant trois etapes : rearrangement des particules et du brai, compaction et consolidation et enfin la finition. Ces travaux ont montre en outre que le temps de compaction joue un role tres important dans la definition des proprietes finales des anodes. Ainsi, en plus du type de brai, du taux de brai et du type de coke, il faut tenir compte du temps de sur-compaction et de sous-compaction. En effet, ceci a ete demontre a travers les deux validations qui ont ete realisees. Les resultats de la caracterisation des echantillons (venant des anodes de la campagne de decembre 2015) ont montre qu'une anode compactee a un temps optimal acquiert une bonne resistance a la compression et sa resistivite electrique baisse. En outre, on note que le temps de compaction dans notre cas a baisse legerement avec l'augmentation de la pression des ballons de haut du vibrocompacteur. Ce qui a eu pour effet d'augmenter la densite crue de l'anode. Toutefois, il faut s'abstenir de generaliser ce constat car le nombre d'anodes testees est faible dans notre cas. Par ailleurs, cette etude montre que le temps necessaire pour le formage d'une anode croit avec l'augmentation du taux de brai et baisse legerement avec l'augmentation de la pression des ballons. (Abstract shortened by ProQuest.).

Pour un enseignement aspectuo-modal et illustre des temps du passe (For an Illustrated, Modal-Aspectual Teaching of the Past Tenses).

ERIC Educational Resources Information Center

Gezundhajt, Henriette

2000-01-01

Demonstrates how multimedia tools can be combined with an enunciation based analysis of the French verb system in order to develop innovative ways of teaching the imparfait and passe compose. (Author/VWL)

Cost Analysis of Remediation Systems for Depleted Uranium

DTIC Science & Technology

2014-04-01

situ stabilization and phytoremediation . In-situ stabilization includes the use of amend- ments, capping, and grouting to immobilize the contaminant in...its current location. Adding amendments to the soil solidifies the DU into insoluble particles. Phytoremediation is the use of plants to help reduce

Focused Logistics: Putting Agility in Agile Logistics

DTIC Science & Technology

2011-05-19

list, ahead of companies like American Express, DuPont and Coca Cola ; Supports nearly 1,900 weapon systems; DLA manages eight supply chains and...35 7) Force Health Protection...Distribution, Information Fusion, Joint Theater Logistics Command and Control, Multinational Logistics, Joint Health Services Support, and Agile

Carbon sequestration potential for forage and pasture systems

USDA-ARS?s Scientific Manuscript database

Grassland soils represent a large reservoir of organic and inorganic carbon. Regionally, grasslands are annual CO2 sources or sinks depending on crop and soil management, current soil organic carbon (SOC) concentration and climate. Land management changes (LMC) impact SOC sequestration rate, the du...

Depleted uranium dust from fired munitions: physical, chemical and biological properties.

PubMed

Mitchel, R E J; Sunder, S

2004-07-01

This paper reports physical, chemical and biological analyses of samples of dust resulting from munitions containing depleted uranium (DU) that had been live-fired and had impacted an armored target. Mass spectroscopic analysis indicated that the average atom% of U was 0.198 +/- 0.10, consistent with depleted uranium. Other major elements present were iron, aluminum, and silicon. About 47% of the total mass was particles with diameters <300 microm, of which about 14% was <10 microm. X-ray diffraction analysis indicated that the uranium was present in the sample as uranium oxides-mainly U3O7 (47%), U3O8 (44%) and UO2 (9%). Depleted uranium dust, instilled into the lungs or implanted into the muscle of rats, contained a rapidly soluble uranium component and a more slowly soluble uranium component. The fraction that underwent dissolution in 7 d declined exponentially with increasing initial burden. At the lower lung burdens tested (<15 microg DU dust/lung) about 14% of the uranium appeared in urine within 7 d. At the higher lung burdens tested (~80-200 microg DU dust/lung) about 5% of the DU appeared in urine within 7 d. In both cases about 50% of that total appeared in urine within the first day. DU implanted in muscle similarly showed that about half of the total excreted within 7 d appeared in the first day. At the lower muscle burdens tested (<15 microg DU dust/injection site) about 9% was solubilized within 7 d. At muscle burdens >35 microg DU dust/injection site about 2% appeared in urine within 7 d. Natural uranium (NU) ore dust was instilled into rat lungs for comparison. The fraction dissolving in lung showed a pattern of exponential decline with increasing initial burden similar to DU. However, the decline was less steep, with about 14% appearing in urine for lung burdens up to about 200 microg NU dust/lung and 5% at lung burdens >1,100 microg NU dust/lung. NU also showed both a fast and a more slowly dissolving component. At the higher lung burdens of both DU and NU that showed lowered urine excretion rates, histological evidence of kidney damage was seen. Kidney damage was not seen with the muscle burdens tested. DU dust produced kidney damage at lower lung burdens and lower urine uranium levels than NU dust, suggesting that other toxic metals in DU dust may contribute to the damage.

Improved Fast Centralized Retransmission Scheme for High-Layer Functional Split in 5G Network

NASA Astrophysics Data System (ADS)

Xu, Sen; Hou, Meng; Fu, Yu; Bian, Honglian; Gao, Cheng

2018-01-01

In order to satisfy the varied 5G critical requirements and the virtualization of the RAN hardware, a two-level architecture for 5G RAN has been studied in 3GPP 5G SI stage. The performance of the PDCP-RLC split option and intra-RLC split option, two mainly concerned options for high layer functional split, exist an ongoing debate. This paper firstly gives an overview of CU-DU split study work in 3GPP. By the comparison of implementation complexity, the standardization impact and system performance, our evaluation result shows the PDCP-RLC split Option outperforms the intra-RLC split option. Aiming to how to reduce the retransmission delay during the intra-CU inter-DU handover, the mainly drawback of PDCP-RLC split option, this paper proposes an improved fast centralized retransmission solution with a low implementation complexity. Finally, system level simulations show that the PDCP-RLC split option with the proposed scheme can significantly improve the UE’s experience.

Stress: The Special Educator's Perspective.

ERIC Educational Resources Information Center

Raschke, Donna; And Others

1988-01-01

The article describes approaches special education teachers can take to reduce stress including diet and exercise, relaxation techniques, use of social support systems, goal setting, time management, and networking. A survey of special education teachers found the use of humor the most common strategy for coping with stress. (DB)

32 CFR 1651.3 - Procedures for taking an appeal.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 1651.3 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM... Selective Service appeals to a district appeal board he shall place in the registrant's file a written... appealing is inappropriate, directing attention to any information in his file, and setting out any...

A Capital Assets Preservation Program.

ERIC Educational Resources Information Center

Heiman, Ralph

1989-01-01

New York State officials have created an efficient capital planning system that is a prescribed set of procedures and actions within a program planning manual and two software modules. The program is a series of logical steps that school districts must take to successfully implement their preservation plans. (MLF)

Long-term fate of depleted uranium at Aberdeen and Yuma Proving Grounds: Human health and ecological risk assessments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ebinger, M.H.; Beckman, R.J.; Myers, O.B.

1996-09-01

The purpose of this study was to evaluate the immediate and long-term consequences of depleted uranium (DU) in the environment at Aberdeen Proving Ground (APG) and Yuma Proving Ground (YPG) for the Test and Evaluation Command (TECOM) of the US Army. Specifically, we examined the potential for adverse radiological and toxicological effects to humans and ecosystems caused by exposure to DU at both installations. We developed contaminant transport models of aquatic and terrestrial ecosystems at APG and terrestrial ecosystems at YPG to assess potential adverse effects from DU exposure. Sensitivity and uncertainty analyses of the initial models showed the portionsmore » of the models that most influenced predicted DU concentrations, and the results of the sensitivity analyses were fundamental tools in designing field sampling campaigns at both installations. Results of uranium (U) isotope analyses of field samples provided data to evaluate the source of U in the environment and the toxicological and radiological doses to different ecosystem components and to humans. Probabilistic doses were estimated from the field data, and DU was identified in several components of the food chain at APG and YPG. Dose estimates from APG data indicated that U or DU uptake was insufficient to cause adverse toxicological or radiological effects. Dose estimates from YPG data indicated that U or DU uptake is insufficient to cause radiological effects in ecosystem components or in humans, but toxicological effects in small mammals (e.g., kangaroo rats and pocket mice) may occur from U or DU ingestion. The results of this study were used to modify environmental radiation monitoring plans at APG and YPG to ensure collection of adequate data for ongoing ecological and human health risk assessments.« less

On the definition of the concepts thinking, consciousness, and conscience.

PubMed Central

Monin, A S

1992-01-01

A complex system (CS) is defined as a set of elements, with connections between them, singled out of the environment, capable of getting information from the environment, capable of making decisions (i.e., of choosing between alternatives), and having purposefulness (i.e., an urge towards preferable states or other goals). Thinking is a process that takes place (or which can take place) in some of the CS and consists of (i) receiving information from the environment (and from itself), (ii) memorizing the information, (iii) the subconscious, and (iv) consciousness. Life is a process that takes place in some CS and consists of functions i and ii, as well as (v) reproduction with passing of hereditary information to progeny, and (vi) oriented energy and matter exchange with the environment sufficient for the maintenance of all life processes. Memory is a complex of processes of placing information in memory banks, keeping it there, and producing it according to prescriptions available in the system or to inquiries arising in it. Consciousness is a process of realization by the thinking CS of some set of algorithms consisting of the comparison of its knowledge, intentions, decisions, and actions with reality--i.e., with accumulated and continuously received internal and external information. Conscience is a realization of an algorithm of good and evil pattern recognition. PMID:1631060

Antenna Near-Field Probe Station Scanner

NASA Technical Reports Server (NTRS)

Darby, William G. (Inventor); Miranda, Felix A. (Inventor); Zaman, Afroz J. (Inventor); Lee, Richard Q. (Inventor); Barr, Philip J. (Inventor); Lambert, Kevin M (Inventor)

2011-01-01

A miniaturized antenna system is characterized non-destructively through the use of a scanner that measures its near-field radiated power performance. When taking measurements, the scanner can be moved linearly along the x, y and z axis, as well as rotationally relative to the antenna. The data obtained from the characterization are processed to determine the far-field properties of the system and to optimize the system. Each antenna is excited using a probe station system while a scanning probe scans the space above the antenna to measure the near field signals. Upon completion of the scan, the near-field patterns are transformed into far-field patterns. Along with taking data, this system also allows for extensive graphing and analysis of both the near-field and far-field data. The details of the probe station as well as the procedures for setting up a test, conducting a test, and analyzing the resulting data are also described.

L'effet Hall Quantique

NASA Astrophysics Data System (ADS)

Samson, Thomas

Nous proposons une methode permettant d'obtenir une expression pour la conductivite de Hall de structures electroniques bidimensionnelles et nous examinons celle -ci a la limite d'une temperature nulle dans le but de verifier l'effet Hall quantique. Nous allons nous interesser essentiellement a l'effet Hall quantique entier et aux effets fractionnaires inferieurs a un. Le systeme considere est forme d'un gaz d'electrons en interaction faible avec les impuretes de l'echantillon. Le modele du gaz d'electrons consiste en un gaz bidimensionnel d'electrons sans spin expose perpendiculairement a un champ magnetique uniforme. Ce dernier est decrit par le potentiel vecteur vec{rm A} defini dans la jauge de Dingle ou jauge symetrique. Conformement au formalisme de la seconde quantification, l'hamiltonien de ce gaz est represente dans la base des etats a un-corps de Dingle |n,m> et exprime ainsi en terme des operateurs de creation et d'annihilation correspondants a_sp{ rm n m}{dag} et a _{rm n m}. Nous supposons de plus que les electrons du niveau fondamental de Dingle interagissent entre eux via le potentiel coulombien. La methode utilisee fait appel a une equation mai tresse a N-corps, de nature quantique et statistique, et verifiant le second principe de la thermodynamique. A partir de celle-ci, nous obtenons un systeme d'equations differentielles appele hierarchie d'equations quantique dont la resolution nous permet de determiner une equation a un-corps, dite de Boltzmann quantique, et dictant l'evolution de la moyenne statistique de l'operateur non-diagonal a _sp{rm n m}{dag } a_{rm n}, _{rm m}, sous l'action du champ electrique applique vec{rm E}(t). C'est sa solution Tr(p(t) a _sp{rm n m}{dag} a_{rm n},_ {rm m}), qui definit la relation de convolution entre la densite courant de Hall vec{rm J}_{rm H }(t) et le champ electrique vec {rm E}(t) dont la transformee de Laplace-Fourier du noyau nous fournit l'expression de la conductivite de Hall desiree. Pour une valeur de facteur d'occupation (nombre d'electrons/degenerescence des etats de Dingle) superieure a un, c'est-a-dire en absence d'interaction electron-electron, il nous sera facile d'evaluer cette conductivite a la limite d'une temperature nulle et de demontrer qu'elle tend vers l'une des valeurs quantiques qe^2/h conformement a l'effet Hall quantique entier. Cependant, pour une valeur du facteur d'occupation inferieure a un, c'est-a-dire en presence d'interaction electron-electron, nous ne pourrons evaluer cette limite et obtenir les resultats escomptes a cause de l'impossibilite de determiner l'un des termes impliques. Neanmoins, ce dernier etant de nature statistique, il pourra etre aisement mis en fonction du propagateur du gaz d'electrons dont on doit maintenant determiner une expression en regime effet Hall quantique fractionnaire. Apres avoir demontre l'impuissance de la theorie des perturbations, basee sur le theoreme de Wick et la technique des diagrammes de Feynman, a accomplir cette tache correctement, nous proposons une seconde methode. Celle -ci fait appel au formalisme de l'integrale fonctionnelle et a l'utilisation d'une transformation de Hubbard-Stratonovich generalisee permettant de substituer a l'interaction a deux-corps une interaction effective a un-corps. L'expression finale obtenue bien que non completement resolue, devrait pouvoir etre estimee par une bonne approximation analytique ou au pire numeriquement.

Depleted Uranium Toxicity, Accumulation, and Uptake in Cynodon dactylon (Bermuda) and Aristida purpurea (Purple Threeawn).

PubMed

Butler, Afrachanna D; Wynter, Michelle; Medina, Victor F; Bednar, Anthony J

2016-06-01

Yuma Proving Grounds (YPG) in western Arizona is a testing range where Depleted uranium (DU) penetrators have been historically fired. A portion of the fired DU penetrators are being managed under controlled conditions by leaving them in place. The widespread use of DU in armor-penetrating weapons has raised environmental and human health concerns. The present study is focused on the onsite management approach and on the potential interactions with plants local to YPG. A 30 day study was conducted to assess the toxicity of DU corrosion products (e.g., schoepite and meta-schoepite) in two grass species that are native to YPG, Bermuda (Cynodon dactylon) and Purple Threeawn (Aristida purpurea). In addition, the ability for plants to uptake DU was studied. The results of this study show a much lower threshold for biomass toxicity and higher plant concentrations, particularly in the roots than shoots, compared to previous studies.

A receptor tyrosine kinase, UFO/Axl, and other genes isolated by a modified differential display PCR are overexpressed in metastatic prostatic carcinoma cell line DU145.

PubMed

Jacob, A N; Kalapurakal, J; Davidson, W R; Kandpal, G; Dunson, N; Prashar, Y; Kandpal, R P

1999-01-01

We have used a modified differential display PCR protocol for isolating 3' restriction fragments of cDNAs specifically expressed or overexpressed in metastatic prostate carcinoma cell line DU145. Several cDNA fragments were identified that matched to milk fat globule protein, UFO/Axl, a receptor tyrosine kinase, human homologue of a Xenopus maternal transcript, laminin and laminin receptor, human carcinoma-associated antigen, and some expressed sequence tags. The transcript for milk fat globule protein, a marker protein shown to be overexpressed in breast tumors, was elevated in DU145 cells. The expression of UFO/Axl, a receptor tyrosine kinase, was considerably higher in DU145 cells as compared to normal prostate cells and prostatic carcinoma cell line PC-3. The overexpression of UFO oncogene in DU145 cells is discussed in the context of prostate cancer metastasis.

A new species of Neoperla (Plecoptera: Perlidae) from Zhejiang Province of China.

PubMed

Chen, Zhi-Teng

2016-03-24

The stonefly genus Neoperla Needham (1905) is primarily distributed in eastern North America, Tropical and Temperate Asia and central Africa, with at least 297 species known (Illies 1966, Zwick 1973, Stark & Gaufin 1976, DeWalt et al. 2016). Contributions to Chinese species of Neoperla were made by Chu (1929), Wu & Claassen (1934), Wu (1935, 1938, 1948, 1962, 1973), Yang & Yang (1992, 1995, 1998), Du (1999, 2000a, 2000b), Du et al. (1999, 2001), Du & Sivec (2004, 2005), Du & Wang (2005, 2007), Sivec & Zwick (1987), Li & Wang (2011), Li et al. (2011a, 2011b, 2012a, 2012b, 2013a, 2013b, 2014a, 2014b), Qin et al. (2013), Wang et al. (2013a, 2013b), Li & Zhang (2014), Kong et al. (2014), Wang et al. (2014), Chen & Du (2015). Herein, a new species of this genus is described from Taizhou, Zhejiang Province, of eastern coastal China.

Performance comparison of optical interference cancellation system architectures.

PubMed

Lu, Maddie; Chang, Matt; Deng, Yanhua; Prucnal, Paul R

2013-04-10

The performance of three optics-based interference cancellation systems are compared and contrasted with each other, and with traditional electronic techniques for interference cancellation. The comparison is based on a set of common performance metrics that we have developed for this purpose. It is shown that thorough evaluation of our optical approaches takes into account the traditional notions of depth of cancellation and dynamic range, along with notions of link loss and uniformity of cancellation. Our evaluation shows that our use of optical components affords performance that surpasses traditional electronic approaches, and that the optimal choice for an optical interference canceller requires taking into account the performance metrics discussed in this paper.

Crew/computer communications study. Volume 1: Final report. [onboard computerized communications system for spacecrews

NASA Technical Reports Server (NTRS)

Johannes, J. D.

1974-01-01

Techniques, methods, and system requirements are reported for an onboard computerized communications system that provides on-line computing capability during manned space exploration. Communications between man and computer take place by sequential execution of each discrete step of a procedure, by interactive progression through a tree-type structure to initiate tasks or by interactive optimization of a task requiring man to furnish a set of parameters. Effective communication between astronaut and computer utilizes structured vocabulary techniques and a word recognition system.

Middle and late quaternary oceanography and climatology of the Zaire-Congo fan and the adjacent Eastern Angola basin

NASA Astrophysics Data System (ADS)

Jansen, J. H. F.; Van Weering, T. C. E.; Gieles, R.; Van Iperen, J.

La stratigraphie quaternaire du delta profond du Zaïre est établie sur la base des variations verticales des teneurs en carbonate, de l'analyse micropalaéontologique et des datations 14C et 230Th de 33 carottes. La vitesse des accumulations carbonatées et non carbonatées considérée en même temps que la conservation des carbonates nous conduit à distinguer les trois principaux facteurs à l'origine des concentrations en carbonate: production, dissolution et dilution par les particules non carbonatées. Les plus fortes productions carbonatées interviennent pendant les optima climatiques des interglaciaires tandis que les plus petites teneurs en carbonates sont probablement aussi liées à une augmentation de l'accumulation calcaire. Les fluctuations sont amplifiées par les effects de la dissolution qui est intense pendant les glaciaires et par les changements du rythme de la sédimentation terrigène. Dans la partie centrale du delta profond, un lobe de forte production carbonatée est localisé en permanence, il n'est pas associé à une zone de forte production de phytoplancton. Ce lobe est la conséquence d'un fort développement du zooplancton qui, pendant l'Holocène et les périodes interglaciaires, se multiplie à partir de cette floraison côtière de phytoplancton. Pendant les glaciaires, l'intensification de la circulation océanique déplace la zone des courants ascendants vers la latitude du delta du Zaïre. Dans deux carottes voisines de la bordure externe du plateau, une forte production en carbonates est observée entre 27 000 et 15 400 ans BP, elle est liée aux courants ascendants provoqués par l'intensification du courant de Benguela, et à une diminution de la sédimentation non carbonatée de de l'enfouissement du carbone organique à ˜ 14 500 ans BP. Une forte accumulation carbonatée se prolonge jusqu'à ˜12 500 ans BP, ce qui résulte un pic de conservation carbonatée à 14 000 ans BP qui n'est pas lié à un phénomène océanique. Une bréve intensification du compensation des carbonates et de la lysocline interviennent à des profondeurs moins grandes (4400 m et 3800 m) pendant les périodes glaciaires que de nos jours (5600 m et 4800 m). Les deux profondeurs des phases interglaciaires sont plus proches des profondeurs des phases glaciaires que de l'Holocène en fonction des dissolutions post-sédimentaires qui sont intervenues pendant les épisodes glaciaires consécutifs. L'hydrographie du Bassin de l'Angola n'apporte pas de preuves quant à des fluctuations des eaux profondes antarctiques qui auraient provoqué des cycles de dissolution des carbonates du Quaternaire de ce Bassin.

Mechanisms of Military Coatings Degradation

DTIC Science & Technology

2003-08-01

fluoride (DuPont Inc., Buffalo, NY) release film. Additionally a primer and topcoat system were also prepared onto a stainless steel mesh substrate...Based Epoxy Surface Treatment: TT- C-490 Zinc Phosphate on a steel s B=(64159), LOW VOC and Zero HAP ARMY SYSTEM Top Coat: MIL-DTL-64159 Water...Zinc Phosphate on a steel su C=(85285), NAVY CONTROL SYSTEM Top Coat: MIL-C-85285 Solvent based Polyurethane Alip polyols Primer: MIL-P

A Cost Prediction Model for Electronic Systems Flight Test Costs.

DTIC Science & Technology

1983-09-01

development. It was found that a significant cost estimating relationship (CER) exists between costs and the characteristics of the flight test design. Using...University In Partial Fulfillment of the Requirements for the Degree of Master of Science in Systems Management By C ., Thomas 3. DuPre’, BS Accession...SYSTEMS MANAGEMENT DATE: 28 September 1983 COMMITTEE CHA. ICEAfER it TABLE OF CONTENTS Page LIST OF TABLES ......................... vi LIST OF FIGURES

40 CFR 52.1570 - Identification of plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... County 2.0 E. I. du Pont de Nemours & Co Deepwater, Salem County 1.5 Heinz-USA Salem City, Salem County 2... County 2.0 Atlantic City Electric Deepwater Station Penns Grove, Salem County 1.5 E. I. du Pont de... County 2.0 E. I. du Pont de Nemours & Co Deepwater, Salem County 1.5 Heinz-U.S.A Salem City, Salem County...

Speaking Truth to Power: Du Bois as Educator and Community Activist

ERIC Educational Resources Information Center

Grant, Carl A.; Grant, Paul D.

2017-01-01

This article uses W. E. B. Du Bois's work as an education and community activist to discuss race, oppression, and speaking-back to power in this time of racialized policies enacted by the Trump administration. This article centers a comparative discussion of the racialization of democracy by presidents Wilson and Trump to show the ways Du Bois was…

Race towards Freedom: W.E.B. Du Bois and the Tradition of Fugitive Black Study

ERIC Educational Resources Information Center

Tinson, Christopher M.

2017-01-01

This essay centers the defense of black educational possibility in the work of historian, pioneering sociologist, and scholar, W.E.B. Du Bois (1868-1963) as a conduit igniting what critical social theorists Stefano Harney and Fred Moten (2013) call Fugitive Black Study. The critical appreciation of Du Bois forces us to consider the weight of…

College of DuPage Planning Process: College of DuPage Planning, the Foundation for Decision Making.

ERIC Educational Resources Information Center

College of DuPage, Glen Ellyn, IL. Office of Research and Planning.

At College of DuPage (CD), in Glen Ellyn, Illinois, institutional planning is a multi-level, on-going process involving continuous college-wide input. The nine schematic levels in the CD planning process are interconnected and progress from global and broad-based issues, answering such questions as why the college exists, to concrete levels…

Canadian Forces Training and Mental Preparation for Adversity: Empirical Review of Stoltz ’Adversity Quotient (AQ) Training for Optimal Response to Adversity’, A Review of the AQ Literature and Supporting Studies

DTIC Science & Technology

2002-07-01

canadiennes. Enfin, nous faisons des recommandations aux FC sur la mise en ceuvre duS processus de d6veloppement du QA comme mesure proactive. Un examen...critique des ouvrages lies au QA et A d’autres sujets connexes a montr6 que le concept du QA est fond6 sur un certain nombre de thdories sens~es sur la...rdsilience. Cependant, m~me si le cadre th~orique et le programme de d6veloppement du QA pourraicnt 8tre valides dans un contexte industriel

Science Town 2.0: An integrating Concept for S&T Support for Multi-Agency Crisis and Disaster Management

DTIC Science & Technology

2012-12-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2012 DRDC CSS TM 2012-029 i...importantes forces d’application de la loi et de sécurité nationale de l’histoire du Canada. L’empreinte de la sécurité du théâtre d’opérations des Jeux...sécurité et de défense par la mise en place d’une « ville scientifique » mobile. La réussite du déploiement des

Structures spatiales localisées dans un oscillateur paramétrique optique (OPO)

NASA Astrophysics Data System (ADS)

Coulibaly, S.; Durniak, C.; Taki, M.

2004-11-01

La prise en compte du caractère non uniforme du pompage optique dans l'étude linéaire et faiblement non linéaire d'un OPO dégénéré (DOPO) a permis de mettre en évidence la discrétisation du seuil et l'existence de structures spatiales localisées de type Hermite-Gauss. L'évolution spatio-temporelle du signal en sortie est quant à elle gouvernée par l'équation de Ginzburg-Landau réelle dont les coefficients dépendent des variables d'espace.

Overview of the Capstone Depleted Uranium Study of Aerosols from Impact with Armored Vehicles: Test Setup and Aerosol Generation, Characterization, and Application in Assessing Dose and Risk

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parkhurst, MaryAnn; Guilmette, Raymond A.

2009-03-01

The Capstone Depleted Uranium (DU) Aerosol Characterization and Risk Assessment Study was conducted to generate data about DU aerosols generated during the perforation of armored combat vehicles with large-caliber DU penetrators, and to apply the data in assessments of human health risks to personnel exposed to these aerosols, primarily through inhalation, during the 1991 Gulf War or in future military operations. The Capstone study consisted of two components: 1) generating, sampling and characterizing DU aerosols by firing at and perforating combat vehicles and 2) applying the source-term quantities and characteristics of the aerosols to the evaluation of doses and risks.more » This paper reviews the background of the study including the bases for the study, previous reviews of DU particles and health assessments from DU used by the U.S. military, the objectives of the study components, the participants and oversight teams, and the types of exposures it was intended to evaluate. It then discusses exposure scenarios used in the dose and risk assessment and provides an overview of how the field tests and dose and risk assessments were conducted.« less

Role of SMAD4 in the mechanism of valproic acid's inhibitory effect on prostate cancer cell invasiveness.

PubMed

Jiang, Wei; Zheng, Yi; Huang, Zhongxian; Wang, Muwen; Zhang, Yinan; Wang, Zheng; Jin, Xunbo; Xia, Qinghua

2014-05-01

To investigate the influence of the histone deacetylase inhibitor valproic acid (VPA) on SMAD4 expression and invasive ability of prostate cancer cell lines. DU145 and PC3 cell lines were treated with 0, 2, and 5 mMol/l of VPA; invasion of DU145 and PC3 cells were then examined by transwell assay. Immunohistochemistry and Western blot were used to examine SMAD4 protein expression in DU145 and PC3 cells. Compared with controls, VPA significantly suppressed invasiveness in both PC3 and DU145 cells in a dose-dependent way (P < 0.05). VPA also inhibited AKT protein (which was regarded as an effective indicator here), and meanwhile, SMAD4 expression was down-regulated after VPA treatment in a dose-dependent manner in both DU145 (P < 0.05) and PC3 (P < 0.01) cells. Valproic acid could suppress invasiveness of prostate cancer cell lines PC3 and Du145, possibly through multiple pathways other than the SAMD4 pathway. This implies that VPA treatment combined with other SMAD4 enhancers could form a basis for a novel prostate cancer treatment.

Up-regulating of RASD1 and apoptosis of DU-145 human prostate cancer cells induced by formononetin in vitro.

PubMed

Liu, Xiao-Jia; Li, Yun-Qian; Chen, Qiu-Yue; Xiao, Sheng-Jun; Zeng, Si-En

2014-01-01

Prostate cancer is one of the most prevalent malignant cancers in men. The isoflavone formononetin is a main active component of red clover plants. In the present study, we assessed the effect of formononetin on human prostate cancer DU-145 cells in vitro, and elucidated possible mechanisms. DU-145 cells were treated with different concentrations of formononetin and cell proliferation was assessed by MTT assay, cell apoptosis by Hoechst 33258 and flow cytometry, and protein levels of RASD1, Bcl-2 and Bax by Western blotting. The results showed that formononetin inhibited the proliferation of DU-145 cells in a dose-dependent manner. DU-145 cells treated with different concentrations of formononetin displayed obvious morphological changes of apoptosis under fluorescence microscopy. In addition, formononetin increased the proportion of early apoptotic DU-145 cells, down-regulated the protein levels of Bcl-2 and up-regulated those of RASD1 and Bax. The level of RASD1 reached its maximum at 48 h post-treatment, and rapidly decreased thereafter. Together, we present evidence that formononetin triggered cell apoptosis through the mitochondrial apoptotic pathway by up-regulating RASD1.

Ensemble des troubles causés par l'alcoolisation fœtale : lignes directrices canadiennes concernant le diagnostic

PubMed Central

Chudley, Albert E.; Conry, Julianne; Cook, Jocelynn L.; Loock, Christine; Rosales, Ted; LeBlanc, Nicole

2005-01-01

Résumé LE DIAGNOSTIC DE L'ENSEMBLE DES TROUBLES CAUSÉS PAR L'ALCOOLISATION FÉTALE (ETCAF) est complexe et l'élaboration de lignes directrices concernant le diagnostic est justifiée. Un sous-comité du Comité consultatif national de l'Agence de santé publique du Canada sur l'Ensemble des troubles causés par l'alcoolisation fœtale a examiné, analysé et intégré les méthodes de diagnostic actuelles afin de parvenir à une méthode de diagnostic normalisée faisant le consensus au Canada. L'objet du présent document est d'examiner et de clarifier l'utilisation des systèmes de diagnostic actuels et de formuler des recommandations quant à leur application pour le diagnostic des déficiences liées à l'ETCAF chez des individus de tous les âges. Les lignes directrices sont fondées sur un vaste consensus de praticiens et d'autres intervenants spécialisés dans le domaine. Ces lignes directrices ont été organisées en sept catégories, soit le dépistage et l'orientation vers les spécialistes, l'examen physique et le diagnostic différentiel, l'évaluation du comportement neurologique, le traitement et le suivi, les antécédents de consommation d'alcool de la mère pendant la grossesse, les critères du diagnostic pour le syndrome d'alcoolisation fœtale (SAF), SAF partiel et troubles neurologiques du développement liés à l'alcool, l'harmonisation de l'Institute of Medicine (IOM) et des approches du Code diagnostique à 4 chiffres. Le diagnostic exige une évaluation complète des antécédents, ainsi qu'un examen physique et du comportement neurologique, tout en recourant à une approche multidisciplinaire. Les présentes lignes directrices pour le diagnostic du syndrome d'alcoolisation fœtale et des déficiences qui y sont associées sont les premières à avoir été élaborées au Canada et elles sont fondées sur la consultation d'un grand éventail de spécialistes du diagnostic.

Étude des déterminants individuels de l’adoption du dossier de santé électronique du Québec

PubMed Central

Mezni, H; M-P, Gagnon; Duplantie, J

2016-01-01

Résumé Objectif Selon des études précédentes, les dossiers de santé électroniques peuvent améliorer l’efficacité, la sécurité et la qualité de la prise en charge médicale. Cependant, les prestataires de soins restent réticents quant à son utilisation, ce qui limite son impact sur le système de santé. La présente étude avait pour objectif d’évaluer les perceptions des médecins face au dossier de santé du Québec. Méthodes À partir d’une revue de la littérature sur les facteurs influençant l’adoption des nouvelles technologies de l’information et des communications (NTIC) en général et de la cybersanté en particulier, nous avons élaboré un questionnaire semi-structuré. Au total, 12 médecins utilisateurs potentiels du dossier de santé du Québec (DSQ) ont complété et retourné le questionnaire. Par la suite, nous avons opéré une analyse thématique de contenu, suivie par une théorisation des concepts obtenus. Résultats L’intention d’adopter le DSQ est influencée positivement par l’utilité perçue, la facilité d’utilisation perçue, la démonstrabilité des résultats, la compatibilité du système avec la pratique et l’autoefficacité informatique perçue par les médecins. Inversement, la résistance au changement influence négativement l’adoption du DSQ par les médecins. Conclusion L’identification des déterminants de l’adoption du dossier de santé du Québec est cruciale pour les responsables du secteur de la santé au Québec. Il sera ainsi possible de saisir les attentes des utilisateurs potentiels et d’ajuster les stratégies d’implantation en vue de favoriser une meilleure intégration de cette technologie dans les pratiques médicales. PMID:27867453

Modelisation frequentielle de la permittivite du beton pour le controle non destructif par georadar

NASA Astrophysics Data System (ADS)

Bourdi, Taoufik

Le georadar (Ground Penetrating Radar (GPR)) constitue une technique de controle non destructif (CND) interessante pour la mesure des epaisseurs des dalles de beton et la caracterisation des fractures, en raison de ses caracteristiques de resolution et de profondeur de penetration. Les equipements georadar sont de plus en plus faciles a utiliser et les logiciels d'interpretation sont en train de devenir plus aisement accessibles. Cependant, il est ressorti dans plusieurs conferences et ateliers sur l'application du georadar en genie civil qu'il fallait poursuivre les recherches, en particulier sur la modelisation et les techniques de mesure des proprietes electriques du beton. En obtenant de meilleures informations sur les proprietes electriques du beton aux frequences du georadar, l'instrumentation et les techniques d'interpretation pourraient etre perfectionnees plus efficacement. Le modele de Jonscher est un modele qui a montre son efficacite dans le domaine geophysique. Pour la premiere fois, son utilisation dans le domaine genie civil est presentee. Dans un premier temps, nous avons valide l'application du modele de Jonscher pour la caracterisation de la permittivite dielectrique du beton. Les resultats ont montre clairement que ce modele est capable de reproduire fidelement la variation de la permittivite de differents types de beton sur la bande de frequence georadar (100 MHz-2 GHz). Dans un deuxieme temps, nous avons montre l'interet du modele de Jonscher en le comparant a d'autres modeles (Debye et Debye-etendu) deja utilises dans le domaine genie civil. Nous avons montre aussi comment le modele de Jonscher peut presenter une aide a la prediction de l'efficacite de blindage et a l'interpretation des ondes de la technique GPR. Il a ete determine que le modele de Jonscher permet de donner une bonne presentation de la variation de la permittivite du beton dans la gamme de frequence georadar consideree. De plus, cette modelisation est valable pour differents types de beton et a differentes teneurs en eau. Dans une derniere partie, nous avons presente l'utilisation du modele de Jonscher pour l'estimation de l'epaisseur d'une dalle de beton par la technique GPR dans le domaine frequentiel. Mots-cles : CND, beton, georadar , permittivite, Jonscher

Prediction du profil de durete de l'acier AISI 4340 traite thermiquement au laser

NASA Astrophysics Data System (ADS)

Maamri, Ilyes

Les traitements thermiques de surfaces sont des procedes qui visent a conferer au coeur et a la surface des pieces mecaniques des proprietes differentes. Ils permettent d'ameliorer la resistance a l'usure et a la fatigue en durcissant les zones critiques superficielles par des apports thermiques courts et localises. Parmi les procedes qui se distinguent par leur capacite en terme de puissance surfacique, le traitement thermique de surface au laser offre des cycles thermiques rapides, localises et precis tout en limitant les risques de deformations indesirables. Les proprietes mecaniques de la zone durcie obtenue par ce procede dependent des proprietes physicochimiques du materiau a traiter et de plusieurs parametres du procede. Pour etre en mesure d'exploiter adequatement les ressources qu'offre ce procede, il est necessaire de developper des strategies permettant de controler et regler les parametres de maniere a produire avec precision les caracteristiques desirees pour la surface durcie sans recourir au classique long et couteux processus essai-erreur. L'objectif du projet consiste donc a developper des modeles pour predire le profil de durete dans le cas de traitement thermique de pieces en acier AISI 4340. Pour comprendre le comportement du procede et evaluer les effets des differents parametres sur la qualite du traitement, une etude de sensibilite a ete menee en se basant sur une planification experimentale structuree combinee a des techniques d'analyse statistiques eprouvees. Les resultats de cette etude ont permis l'identification des variables les plus pertinentes a exploiter pour la modelisation. Suite a cette analyse et dans le but d'elaborer un premier modele, deux techniques de modelisation ont ete considerees, soient la regression multiple et les reseaux de neurones. Les deux techniques ont conduit a des modeles de qualite acceptable avec une precision d'environ 90%. Pour ameliorer les performances des modeles a base de reseaux de neurones, deux nouvelles approches basees sur la caracterisation geometrique du profil de durete ont ete considerees. Contrairement aux premiers modeles predisant le profil de durete en fonction des parametres du procede, les nouveaux modeles combinent les memes parametres avec les attributs geometriques du profil de durete pour refleter la qualite du traitement. Les modeles obtenus montrent que cette strategie conduit a des resultats tres prometteurs.

The UAV take-off and landing system used for small areas of mobile vehicles

NASA Astrophysics Data System (ADS)

Ren, Tian-Yu; Duanmu, Qing-Duo; Wu, Bo-Qi

2018-03-01

In order to realize an UAV formation cluster system based on the current GPS and the fault and insufficiency of Beidou integrated navigation system in strong jamming environment. Due to the impact of the compass on the plane crash, navigation system error caused by the mobile area to help reduce the need for large landing sites and not in the small fast moving area to achieve the reality of the landing. By using Strapdown inertial and all-optical system to form Composite UAV flight control system, the photoelectric composite strapdown inertial coupling is realized, and through the laser and microwave telemetry link compound communication mechanism, using all-optical strapdown inertial and visual navigation system to solve the deviation of take-off and landing caused by electromagnetic interference, all-optical bidirectional data link realizes two-way position correction of landing site and aircraft, thus achieves the accurate recovery of UAV formation cluster in the mobile narrow area which the traditional navigation system can't realize. This system is a set of efficient unmanned aerial vehicle Group Take-off/descending system, which is suitable for many tasks, and not only realizes the reliable continuous navigation under the complex electromagnetic interference environment, moreover, the intelligent flight and Take-off and landing of unmanned aerial vehicles relative to the fast moving and small recovery sites in complex electromagnetic interference environment can not only improve the safe operation rate of unmanned aerial vehicle, but also guarantee the operation safety of the aircraft, and the more has important social value for the application foreground of the aircraft.

Ballistic Impact Response of Kevlar 49 and Zylon under Conditions Representing Jet Engine Fan Containment

NASA Technical Reports Server (NTRS)

Pereira, J. Michael; Revilock, Duane M.

2007-01-01

A ballistic impact test program was conducted to provide validation data for the development of numerical models of blade out events in fabric containment systems. The impact response of two different fiber materials - Kevlar 49 (E.I. DuPont Nemours and Company) and Zylon AS (Toyobo Co., Ltd.) was studied by firing metal projectiles into dry woven fabric specimens using a gas gun. The shape, mass, orientation and velocity of the projectile were varied and recorded. In most cases the tests were designed such that the projectile would perforate the specimen, allowing measurement of the energy absorbed by the fabric. The results for both Zylon and Kevlar presented here represent a useful set of data for the purposes of establishing and validating numerical models for predicting the response of fabrics under conditions simulating those of a jet engine blade release situation. In addition some useful empirical observations were made regarding the effects of projectile orientation and the relative performance of the different materials.

Astronomical image data compression by morphological skeleton transformation

NASA Astrophysics Data System (ADS)

Huang, L.; Bijaoui, A.

A compression method adapted for exact restoring of the detected objects and based on the morphological skeleton transformation is presented. The morphological skeleton provides a complete and compact description of an object and gives an efficient compression rate. The flexibility of choosing a structuring element adapted to different images and the simplicity of the implementation are considered to be advantages of the method. The experiment was carried out on three typical astronomical images. The first two images were obtained by digitizing a Palomar Schmidt photographic plate in a coma field with the PDS microdensitometer at Nice Observatory. The third image was obtained by CCD camera at the Pic du Midi Observatory. Each pixel was coded by 16 bits and stored at a computer system (VAX785) with STII format. Each image is characterized by 256 x 256 pixels. It is found that first image represents a stellar field, the second represents a set of galaxies in the Coma, and the third image contains an elliptical galaxy.

Protein Scaffolding for Small Molecule Catalysts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, David

We aim to design hybrid catalysts for energy production and storage that combine the high specificity, affinity, and tunability of proteins with the potent chemical reactivities of small organometallic molecules. The widely used Rosetta and RosettaDesign methodologies will be extended to model novel protein / small molecule catalysts in which one or many small molecule active centers are supported and coordinated by protein scaffolding. The promise of such hybrid molecular systems will be demonstrated with the nickel-phosphine hydrogenase of DuBois et. al.We will enhance the hydrogenase activity of the catalyst by designing protein scaffolds that incorporate proton relays and systematicallymore » modulate the local environment of the catalyticcenter. In collaboration with DuBois and Shaw, the designs will be experimentally synthesized and characterized.« less

Taking the Heat off the School Lunchroom.

ERIC Educational Resources Information Center

Lutz, Raymond P.; And Others

The application of operations research techniques to a public school system's lunch program suggests a possible solution to the problem of rapidly increasing program costs. A computer-assisted menu planner was developed which generated a monthly set of menus satisfying nutritional and Federal standards, and food demand cycles. When compared to the…

Standardized Evaluation for Multi-National Development Programs.

ERIC Educational Resources Information Center

Farrell, W. Timothy

This paper takes the position that standardized evaluation formats and procedures for multi-national development programs are not only desirable but possible in diverse settings. The key is the localization of standard systems, which involves not only the technical manipulation of items and scales, but also the contextual interpretation of…

Relevance of Student Resources in a Flipped MIS Classroom

ERIC Educational Resources Information Center

Adkins, Joni K.

2014-01-01

Flipped classrooms are gaining popularity in various educational settings as proponents report several benefits. In order for flipped classrooms to be successful, students must take responsibility for certain assignments outside of class time. In this study, Management Information Systems students were to learn textbook material by reading the…

SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells.

PubMed

Rybak, Adrian P; Tang, Damu

2013-12-01

SOX2 is an essential transcription factor for stem cells and plays a role in tumorigenesis, however its role in prostate cancer stem cells (PCSCs) remains unclear. We report here a significant upregulation of SOX2 at both mRNA and protein levels in DU145 PCSCs propagated as suspension spheres in vitro. The expression of SOX2 in DU145 PCSCs is positively regulated by epidermal growth factor receptor (EGFR) signaling. Activation of EGFR signaling, following the addition of epidermal growth factor (EGF) or ectopic expression of a constitutively-active EGFR mutant (EGFRvIII), increased SOX2 expression and the self-renewal of DU145 PCSCs. Conversely, a small molecule EGFR inhibitor (AG1478) blocked EGFR activation, reduced SOX2 expression and inhibited PCSC self-renewal activity, implicating SOX2 in mediating EGFR-dependent self-renewal of PCSCs. In line with this notion, ectopic SOX2 expression enhanced EGF-induced self-renewal of DU145 PCSCs, while SOX2 knockdown reduced PCSC self-renewal with EGF treatment no longer capable of enhancing their propagation. Furthermore, SOX2 knockdown reduced the capacity of DU145 PCSCs to grow under anchorage-independent conditions. Finally, DU145 PCSCs generated xenograft tumors more aggressively with elevated levels of SOX2 expression compared to xenograft tumors derived from non-PCSCs. Collectively, we provide evidence that SOX2 plays a critical role in EGFR-mediated self-renewal of DU145 PCSCs. © 2013.

The use of depleted uranium ammunition under contemporary international law: is there a need for a treaty-based ban on DU weapons?

PubMed

Borrmann, Robin

2010-01-01

This article examines whether the use of Depleted Uranium (DU) munitions can be considered illegal under current public international law. The analysis covers the law of arms control and focuses in particular on international humanitarian law. The article argues that DU ammunition cannot be addressed adequately under existing treaty based weapon bans, such as the Chemical Weapons Convention, due to the fact that DU does not meet the criteria required to trigger the applicability of those treaties. Furthermore, it is argued that continuing uncertainties regarding the effects of DU munitions impedes a reliable review of the legality of their use under various principles of international law, including the prohibition on employing indiscriminate weapons; the prohibition on weapons that are intended, or may be expected, to cause widespread, long-term and severe damage to the natural environment; and the prohibition on causing unnecessary suffering or superfluous injury. All of these principles require complete knowledge of the effects of the weapon in question. Nevertheless, the author argues that the same uncertainty places restrictions on the use of DU under the precautionary principle. The paper concludes with an examination of whether or not there is a need for--and if so whether there is a possibility of achieving--a Convention that comprehensively outlaws the use, transfer and stockpiling of DU weapons, as proposed by some non-governmental organisations (NGOs).

Stromal interaction molecule 1 (STIM1) silencing inhibits tumor growth and promotes cell cycle arrest and apoptosis in hypopharyngeal carcinoma.

PubMed

Sun, Yuanhao; Cui, Xiaobo; Wang, Jun; Wu, Shuai; Bai, Yunfei; Wang, Yaping; Wang, Boqian; Fang, Jugao

2015-05-01

As an important pathway maintaining the balance of intracellular calcium (Ca(2+)), store-operated Ca(2+) entry (SOCE) is critical for cellular functions. Stromal interaction molecule 1 (STIM1), a key component of SOCE, plays a dual role as an endoplasmic reticulum Ca(2+) receptor and an SOCE exciter. Aberrant expression of STIM1 could be discovered in several human cancer cells. However, the role of STIM1 in regulating human hypopharyngeal carcinoma still remains unclear. Real-time polymerase chain reaction (PCR) was used to detect expression of STIM1 in human hypopharyngeal carcinoma cell line FaDu. STIM1 on FaDu cells was knocked down by lentiviral transduction method. The biological impacts after knocking down of STIM1 on FaDu cells were investigated in vitro and in vivo. The result of real-time PCR showed that STIM1 was expressed in FaDu cells. Lentiviral transduction efficiently downregulated the expression of STIM1 in FaDu cells at both mRNA and protein levels. Significant downregulation of STIM1 on FaDu cells inhibited cell proliferation, induced cell cycle arrest in G0/G1 phase, promoted cell apoptosis, and restrained cell growth rate. The antigrowth effect of STIM1 silencing was also discovered in FaDu hypopharyngeal tumor model. Our findings indicate that STIM1 is likely to become a new therapeutic target for hypopharyngeal carcinoma treatment.

On the Implementation of Iterative Detection in Real-World MIMO Wireless Systems

DTIC Science & Technology

2003-12-01

multientr~es et multisorties (MIMO) permettent une exploitation remarquable du spectre comparativement aux syst~mes traditionnels A antenne unique...vecteurs symboliques pilotes connus cause une perte de rendement n~gligeable comparativement au cas hypothdtique des connaissances des voies parfaites...useful design guidelines for iterative systems. it does not provide any fundamental understanding as to how the design of the detector can improve the

First Giant Mirror for the ESO VLT Ready at REOSC

NASA Astrophysics Data System (ADS)

1995-11-01

The REOSC Contract In 1989, the European Southern Observatory (ESO), the European Organisation for Astronomy, awarded to REOSC, a subsidiary of the SFIM Group and located in Saint Pierre du Perray (France), a comprehensive contract for the polishing of four 8.2-metre diameter mirrors for the unit telescopes of the ESO Very Large Telescope (VLT) project. These mirrors are the largest ever manufactured and polished. This contract comprises not only the polishing and high-precision optical testing of each giant mirror, but also the safe condition of transportation of the blanks which were manufactured by Schott Glaswerke in Mainz (Germany). In order to fulfill the contract, REOSC conceived, built and equipped a novel, high-tech workshop which would allow to polish and test the mirrors, each of which has a surface area of more than 50 square metres. First 8.2-Metre Mirror is Ready and within Specifications The REOSC polishing facility for giant mirrors was built in Saint Pierre du Perray, just south of Paris. It is equipped with two machines: one for grinding and the other for polishing the mirrors, and both with 150-actuator systems that support the thin and flexible mirrors. All equipment is computer controlled. State-of-the-art interferometers probe the accuracy of the mirror surface as the polishing proceeds; they are installed at the top level of the facility in a 30-metre high tower, at the centre of the mirror's radius of curvature. The success of the work at REOSC is now evident by the fact that careful measurements of the first mirror earlier this month have shown that the final optical surface is correct to within 0.00005 millimetres. For illustration, this corresponds to an accuracy of only 1 millimetre deviation over a surface with a diameter of 165 kilometres (equivalent to the entire Paris area)! ESO Receives the First VLT Mirror After having been carefully placed in a special transport box designed by REOSC, the first mirror blank, weighing 23.5 tons and with a replacement value of about 20 million DEM, was transported from Mainz to Saint Pierre du Perray in July 1993. The shaping and polishing phases lasted two years and were completed in October 1995. After one month's hard work, dedicated to optical and mechanical verifications by ESO and REOSC, the mirror's various characteristics have now been found to be in accordance with the contract specifications. Following the technical acceptance, the first mirror was re-installed in its transport container on November 13, 1995. It will thereafter be formally handed over to ESO during a ceremony at REOSC on Tuesday, November 21, 1995. The mirror will be stored at the REOSC facility until its future departure to ESO's VLT Observatory on Cerro Paranal, a 2650 m high summit in the Andean Cordillera in northern Chile. Here it will be installed in the first VLT unit telescope, soon after the assembly of the mechanical parts has been completed. Future Plans at REOSC The polishing of the second VLT mirror, as well as the grinding of the third mirror which was transported from Mainz to Saint Pierre du Perray at the beginning of October 1995, have already started. The transport of the fourth blank will take place in March 1996. With the construction, in a subsequent phase, of a workshop of more than 6000 square metres and mostly dedicated to space and astronomy, the SFIM group will have invested more than 50 million French Francs at the Saint Pierre du Perray site alone. The group is also involved in the contract related to the actuator support system; this is a clear indication of its determination to maintain its position within this scientific-technological market. In addition to the ESO VLT mirrors, REOSC will also polish the two 8.2-metre diameter mirrors of the Gemini programme of the Association of Universities for Research in Astronomy (AURA) in the United States. This important work was entrusted REOSC, following an international call for tenders, in which also US firms participated. How to obtain ESO Press Information ESO Press Information is made available on the World-Wide Web (URL: http://www.eso.org../). ESO Press Photos may be reproduced, if credit is given to the European Southern Observatory.

JPRS Report, Soviet Union, Military Affairs

DTIC Science & Technology

1988-11-18

instructions to take an active part in ispolkoms’ work to repair and maintain graves of Soviet soldiers and to set up a reliable system to register...He writes that "if ’dedovshchina’ [word derives from "ded," meaning grandfather, and it connotes a system of antiquated attitudes and behavior of...automatic loading system for the main gun and cutting the crew size from four to three. This would make it possible to lower the turret somewhat

Scheduling Randomly-Deployed Heterogeneous Video Sensor Nodes for Reduced Intrusion Detection Time

NASA Astrophysics Data System (ADS)

Pham, Congduc

This paper proposes to use video sensor nodes to provide an efficient intrusion detection system. We use a scheduling mechanism that takes into account the criticality of the surveillance application and present a performance study of various cover set construction strategies that take into account cameras with heterogeneous angle of view and those with very small angle of view. We show by simulation how a dynamic criticality management scheme can provide fast event detection for mission-critical surveillance applications by increasing the network lifetime and providing low stealth time of intrusions.

Une alternative au cobalt pour la synthese de nanotubes de carbone monoparoi par plasma inductif thermique

NASA Astrophysics Data System (ADS)

Carrier, Jean-Francois

Les nanotubes de carbone de type monoparoi (C-SWNT) sont une classe recente de nanomateriaux qui ont fait leur apparition en 1991. L'interet qu'on leur accorde provient des nombreuses proprietes d'avant-plan qu'ils possedent. Leur resistance mecanique serait des plus rigide, tout comme ils peuvent conduire l'electricite et la chaleur d'une maniere inegalee. Non moins, les C-SWNT promettent de devenir une nouvelle classe de plateforme moleculaire, en servant de site d'attache pour des groupements reactifs. Les promesses de ce type particulier de nanomateriau sont nombreuses, la question aujourd'hui est de comment les realiser. La technologie de synthese par plasma inductif thermique se situe avantageusement pour la qualite de ses produits, sa productivite et les faibles couts d'operation. Par contre, des recherches recentes ont permis de mettre en lumiere des risques d'expositions reliees a l'utilisation du cobalt, comme catalyseur de synthese; son elimination ou bien son remplacement est devenu une preoccupation importante. Quatre recettes alternatives ont ete mises a l'essai afin de trouver une alternative plus securitaire a la recette de base; un melange catalytique ternaire, compose de nickel, de cobalt et d'oxyde d'yttrium. La premiere consiste essentiellement a remplacer la proportion massique de cobalt par du nickel, qui etait deja present dans la recette de base. Les trois options suivantes contiennent de nouveaux catalyseurs, en remplacement au Co, qui sont apparus dans plusieurs recherches scientifiques au courant des dernieres annees: le dioxyde de zircone (ZrO2), dioxyde de manganese (MnO2) et le molybdene (Mo). La methode utilisee consiste a vaporiser la matiere premiere, sous forme solide, dans un reacteur plasma a haute frequence (3 MHz) a paroi refroidi. Apres le passage dans le plasma, le systeme traverse une section dite de "croissance", isolee thermiquement a l'aide de graphite, afin de maintenir une certaine plage de temperature favorable a la synthese de C-SWNT. Le produit final est par la suite recolte sur des filtres metalliques poreux, une fois le systeme mis a l'arret. Dans un premier temps, une analyse thermodynamique, calculee avec le logiciel Fact-Sage, a permis de mettre en lumiere l'etat des differentes produits et reactifs, tout au long de leur passage dans le systeme. Elle a permis de reveler la similitude de composition de la phase liquide du melange catalytique ternaire de base, avec celui du melange binaire, avec nickel et oxyde d'yttrium. Par la suite, une analyse du bilan d'energie, a l'aide d'un systeme d'acquisition de donnees, a permis de determiner que les conditions operatoires des cinq echantillons mis a l'essai etaient similaires. Au total, le produit final a ete caracterise a l'aide de six methodes de caracterisations differentes : l'analyse thermogravimetrique, la diffraction de rayons X, la microscopie electronique a balayage a haute resolution (HRSEM), la microscopie electronique a transmission (MET), la spectroscopie RAMAN, ainsi que la mesure de la surface specifique (BET). Les resultats de ces analyses ont permis de constater, de facon coherente, que le melange a base de molybdene etait celui qui produisait la moins bonne qualite de produit. Ensuite, en ordre croissant, s'en suivait du melange a base de MnO2 et de ZrO2. Le melange de reference, a base de cobalt, est au deuxieme rang en matiere de qualite. La palme revient au melange binaire, dont la proportion est double en nickel. Les resultats de ce travail de recherche permettent d'affirmer qu'il existe une alternative performante au cobalt pour effectuer la synthese de nanotubes de carbone monoparoi, par plasma inductif thermique. Cette alternative est l'utilisation d'un melange catalytique binaire a base de nickel et d'oxyde d'yttrium. Il est suggere que les performances plus faibles des recettes alternatives, moins performantes, pourraient etre expliquees par le profil thermique fixe du reacteur. Ceci pourrait favoriser certains melanges, au detriment des autres, qui possedent des proprietes thermodynamiques differentes. Le montage, l'equipement, ainsi que les parametres d'operations, pourraient etre modifies en fonction de ces catalyseurs afin d'optimiser la synthese. Mots cles : nanotubes de carbone mono paroi, plasma inductif thermique, cobalt, nickel, dioxyde de zirconium, dioxyde de manganese, molybdene, trioxyde d'yttrium et noir de carbone